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Sample records for electron content tec

  1. Long-term trends in the total electron content (TEC)

    Science.gov (United States)

    Laštovička, Jan

    2017-04-01

    The long-term trends in the total electron content (TEC) have very little been studied. Lean et al. (2011; J. Geophys. Res., 116, A00H04, doi:10.1029/2010JA016378) studied trends in TEC globally based on JPL maps for 1995-2010. However, their trends appear to be too positive, which is not plausible taking into account the trends in other ionospheric parameters. Therefore they prefer the less positive trends calculated under the assumption of the same level of solar activity in solar cycle minima 22/23 and 23/24. However, as it is now clear, this is not a correct assumption. Lastovicka (2013; J. Geophys. Res. Space Phys., 118, 3831-3835, doi:10.1002/jgra.50261) selected a region around Florence, Italy, as a region with available historical TEC data based on Faraday rotation measurements and remarkably larger than average trends in TEC by Lean et al. (2011). Historical data from Florence provide no trend in TEC. However, foF2 from Juliusruh provide slight negative trends for 1976-1996 but no trends for 1995-2010. Thus the question of reality of trends by Lean et al. (2011) remained open. Here we use TEC from GIM and JPL data for two European regions with high Lean's trends, regions around Florence and around Prague, using 10-14 LT medians, 1998-2015, yearly average values. A classical approach is applied. First a model of solar activity dependence of TEC is constructed separately for each region from all data. Then model data are subtracted from experimental data and analysis is made with residuals. This analysis shows that early data (1998-2001) are by several TECU lower than they should be according to solar activity, the year 2002 is intermediate and in 2003-2015 the data fit well a weak or rather no trend of TEC. The change in TEC data does not seem to be jump-like, it lasted at least a year, if not longer. Thus the positive TEC trends reported by Lean et al. (2011) appear to be affected by data problem; real trends are evidently less positive if any.

  2. Global Variations of Ionospheric Total Electron Content (TEC ...

    African Journals Online (AJOL)

    User

    monthly variations of ionospheric TEC, results of IGS and COD satellites show that highest mean TEC value is ... serious impact on short wave communication, satellite communication and precise navigation with the Global ... 1998). In the 1980s, researchers started to estimate TECs based on the media dispersivity using.

  3. Ionospheric earthquake effects detection based on Total Electron Content (TEC) GPS Correlation

    Science.gov (United States)

    Sunardi, Bambang; Muslim, Buldan; Eka Sakya, Andi; Rohadi, Supriyanto; Sulastri; Murjaya, Jaya

    2018-03-01

    Advances in science and technology showed that ground-based GPS receiver was able to detect ionospheric Total Electron Content (TEC) disturbances caused by various natural phenomena such as earthquakes. One study of Tohoku (Japan) earthquake, March 11, 2011, magnitude M 9.0 showed TEC fluctuations observed from GPS observation network spread around the disaster area. This paper discussed the ionospheric earthquake effects detection using TEC GPS data. The case studies taken were Kebumen earthquake, January 25, 2014, magnitude M 6.2, Sumba earthquake, February 12, 2016, M 6.2 and Halmahera earthquake, February 17, 2016, M 6.1. TEC-GIM (Global Ionosphere Map) correlation methods for 31 days were used to monitor TEC anomaly in ionosphere. To ensure the geomagnetic disturbances due to solar activity, we also compare with Dst index in the same time window. The results showed anomalous ratio of correlation coefficient deviation to its standard deviation upon occurrences of Kebumen and Sumba earthquake, but not detected a similar anomaly for the Halmahera earthquake. It was needed a continous monitoring of TEC GPS data to detect the earthquake effects in ionosphere. This study giving hope in strengthening the earthquake effect early warning system using TEC GPS data. The method development of continuous TEC GPS observation derived from GPS observation network that already exists in Indonesia is needed to support earthquake effects early warning systems.

  4. Global Variations of Ionospheric Total Electron Content (TEC ...

    African Journals Online (AJOL)

    The processed and archived data taken from IGS and COD satellites has been imported in to a MATLAB code which gave us the results of the value of VTEC. Results of the two satellites revealed that, Out of the selected equinox and solstice day's maximum value of TEC is recorded on March 20/2008 over North and South ...

  5. Are trends in total electron content (TEC) really positive?

    Czech Academy of Sciences Publication Activity Database

    Laštovička, Jan

    2013-01-01

    Roč. 118, č. 6 (2013), s. 3831-3835 ISSN 2169-9380 R&D Projects: GA ČR GAP209/10/1792 Institutional support: RVO:68378289 Keywords : Long-term trends * total electron content Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 3.440, year: 2013 http://onlinelibrary.wiley.com/doi/10.1002/jgra.50261/abstract

  6. An Investigation of Total Electron Content (TEC) Perturbations during Storm-Time Substorms and Non-Storm Substorms

    Science.gov (United States)

    Yizengaw, E.; Hsu, T.; Moldwin, M.; McPherron, R.; Galvan, D.; Komjathy, A.; Mannucci, A.

    2006-12-01

    The response of the ionosphere to geomagnetic activity such as magnetic storms and substorms is important for understanding the energy coupling process between the Sun and the Earth and for forecasting space weather changes. The mid-latitude and low-latitude ionospheric disturbances during magnetic storms have been the focus of study for years. With the introduction of simultaneous worldwide Global Position System (GPS) measurement, it becomes possible to investigate the global ionospheric total electron content (TEC) response to magnetic storms. Significant progress in understandings TEC response to magnetic storms has been obtained by using TEC data. However, while the effects of geomagnetic storm to the TEC has been well studied, the substorm effect on TEC has not been investigated thoroughly. It has been suggested that the penetration of a transient electric field associated with substorms may cause a direct association between magnetic and ionospheric disturbances without a time delay between high and low latitude. If so, such an effect can cause a much faster disturbance in the ionosphere with a time scale of minutes. At the present time, it is not clear whether (or how) ionospheric TEC can respond to substorm within minutes. In this study, we examine whether substorms can cause global change in TEC. We have identified about 500 substorms during fall 2001. There are about 50 storm-time substorms and 450 non-storm substorm. Two different types of TEC data will be used. One is global ionospheric maps (GIM) of TEC created by Jet Propulation Laboratory and the other is the TEC data derived from ~300 ground-based GPS receivers which are approximately aligned in three different longitudinal sectors. The time delay and percentage change of TEC as a function of substorm time will be examined to see how significant the substorm effect to the TEC distribution.

  7. The structure of the latidudinal total electron content (T.E.C.). Gradients over mid-latitude stations

    International Nuclear Information System (INIS)

    Keroub, I.H.

    1976-01-01

    New results concerning the day gradients of Total Electron Contents (T.E.C.) in Haifa region were obtained by the method specific for the determination of TEC in the transverse zone. The latitudinal gradients thus obtained agree with the results obtained by topside sounding (Alouette 1 satellite). A quantitative explanation of the results yielded by the classical counting method is presented. Il implies that all day TEC data obtained by the counting methods in stations situated at middle geomagnetic latitudes such as Haifa, must be corrected

  8. Characterization of GPS total electron content (GPS-TEC in Antarctica from 2004 to 2011

    Directory of Open Access Journals (Sweden)

    Emília Correia

    2013-06-01

    Full Text Available The vertical total electron content (VTEC obtained from 2004 to 2011 at Comandante Ferraz Brazilian Antarctic Station (62.1°S, 58.4°W is analyzed to study the mean diurnal, seasonal and annual variations. The maximum daytime VTEC had an annual variation that decreased from 2004 to 2008, and then starting to increase in 2009, which followed the variation of the solar activity. The daily VTEC shows good linear correlation with solar radiation intensity, which is also dependent on the solar zenithal angle. The mean diurnal VTEC shows a semiannual variation, with larger peaks in equinoxes for all years; no winter anomaly was observed, and in summer, there was no clear diurnal variation. The semiannual variation of the VTEC is also modulated by solar activity, with larger VTEC peaks when the solar activity was higher.

  9. Analysis of Ionospheric Monitoring System (IMS) Total Electron Content (TEC) data and equatorial phase-scintillation data. Scientific report No. 1

    Energy Technology Data Exchange (ETDEWEB)

    Secan, J.A.; Andreasen, C.C.; Fremouw, E.J.; Holland, E.; Mazzella, A.

    1995-07-01

    Many military systems used for communications, command and control, navigation, tracking, and surveillance depend on reliable and relatively noise-free transmission of radiowave signals through the earth`s ionosphere. This report documents the results of the first year of a three-year investigation of various facets of this problem. Two study areas are reported on: (1) an investigation of methods for using signals from Global Positioning System (GPS) satellites to measure ionospheric Total Electron Content (TEC), and (2) a study of the shape and behavior of the phase-scintillation power-density spectrum (PDS) over a scale-size range of 1Os to 1OOs of kilometers. The phase PDS study found that the slope of the phase PDS at these scale sizes is steeper than those found in earlier studies at shorter scales.

  10. US-Total Electron Content Product (USTEC)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The US Total Electron Content (US-TEC) product is designed to specify TEC over the Continental US (CONUS) in near real-time. The product uses a Kalman Filter data...

  11. Variability of the ionospheric plasma density, NmF2, and of Total Electron Content, TEC, over equatorial and low latitude region in Brazil during solar minimum activity

    Science.gov (United States)

    Candido, Claudia; Batista, Inez S.; Negreti, Patricia M. S.; Klausner, Virginia

    The recent solar minimum period was unusually deep and prolonged, which opened a window to observe the ionospheric behavior under unprecedented low solar activity conditions. This work is part of a multi-instrumental effort to investigate the equatorial and low latitude ionosphere over Brazilian sector during low solar activity. We present a study of the ionospheric plasma densities variations through ionosondes measurements and dual frequency GPS receivers (L1= 1275.4 MHz, L2 = 1227.6 MHz) for two equatorial stations, Sao Luis (3° S, 45º W) e Fortaleza (4° S, 39.5° W), and for a station close to the south crest of the equatorial ionization anomaly region, Cachoeira Paulista (23º S, 45º W). From ionosondes we extract the plasma critical frequency foF2 which is related to F2 region peak electron density, NmF2, by the relationship: NmF2 = 1.24 x 104 (foF2)2, and the F2 layer peak height, hmF2. From GPS receivers we used the quantity VTEC (Vertical total electron content). We analyzed the seasonal and local time variations of NmF2 and VTEC, as well as the differences between two solar minima, 2008-2009 and 1996. We observe that the ionospheric plasma densities were lower in 2008-2009 than in 1996 for both regions. In addition, we observe that the lowest plasma densities persisted longer during 2008/2009 than in 1996, especially for nighttime periods. Finally, we applied the wavelet technique to investigate the impact of some distinct time scales drivers on the ionosphere, such as the wave activity from below that seems have been better observed and appreciated during this unusual solar quiescence.

  12. Modelling the main ionospheric trough using the Electron Density Assimilative Model (EDAM) with assimilated GPS TEC

    Science.gov (United States)

    Parker, James A. D.; Eleri Pryse, S.; Jackson-Booth, Natasha; Buckland, Rachel A.

    2018-01-01

    The main ionospheric trough is a large-scale spatial depletion in the electron density distribution at the interface between the high- and mid-latitude ionosphere. In western Europe it appears in early evening, progresses equatorward during the night, and retreats rapidly poleward at dawn. It exhibits substantial day-to-day variability and under conditions of increased geomagnetic activity it moves progressively to lower latitudes. Steep gradients on the trough-walls on either side of the trough minimum, and their variability, can cause problems for radio applications. Numerous studies have sought to characterize and quantify the trough behaviour. The Electron Density Assimilative Model (EDAM) models the ionosphere on a global scale. It assimilates observations into a background ionosphere, the International Reference Ionosphere 2007 (IRI2007), to provide a full 3-D representation of the ionospheric plasma distribution at specified times and days. This current investigation studied the capability of EDAM to model the ionosphere in the region of the main trough. Total electron content (TEC) measurements from 46 GPS stations in western Europe from September to December 2002 were assimilated into EDAM to provide a model of the ionosphere in the trough region. Vertical electron content profiles through the model revealed the trough and the detail of its structure. Statistical results are presented of the latitude of the trough minimum, TEC at the minimum and of other defined parameters that characterize the trough structure. The results are compared with previous observations made with the Navy Ionospheric Monitoring System (NIMS), and reveal the potential of EDAM to model the large-scale structure of the ionosphere.

  13. Validation of NeQuick TEC data ingestion technique against C/NOFS and EISCAT electron density measurements

    Science.gov (United States)

    Nigussie, M.; Radicella, S. M.; Damtie, B.; Yizengaw, E.; Nava, B.; Roininen, L.

    2016-07-01

    This paper investigates a technique to estimate near-real-time electron density structure of the ionosphere. Ground-based GPS receiver total electron content (TEC) at low and high latitudes has been used to assist the NeQuick 2 model. First, we compute model input (effective ionization level) when the modeled slant TEC (sTEC) best fits the measured sTEC by single GPS receiver (reference station). Then we run the model at different locations nearby the reference station and produce the spatial distribution of the density profiles of the ionosphere in the East African region. We investigate the performance of the model, before and after data ingestion in estimating the topside ionosphere density profiles. This is carried out by extracting in situ density from the model at the corresponding location of C/NOFS (Communication/Navigation Outage Forecast System) satellite orbit and comparing the modeled ion density with the in situ ion density observed by Planar Langmuir Probe onboard C/NOFS. It is shown that the performance of the model after data ingestion reproduces the topside ionosphere better up to about 824 km away from the reference station than that before adaptation. Similarly, for high-latitude region, NeQuick 2 adapted to sTEC obtained from high-latitude (Tromsø in Norway) GPS receiver and the model used to reproduce parameters measured by European Incoherent Scatter Scientific Association (EISCAT) VHF radar. It is shown that the model after adaptation shows considerable improvement in estimating EISCAT measurements of electron density profile, F2 peak density, and height.

  14. Determinations of ionosphere and plasmasphere electron content for an African chain of GPS stations

    Directory of Open Access Journals (Sweden)

    A. J. Mazzella Jr.

    2017-05-01

    Full Text Available The confluence of recent instrumentation deployments in Africa with developments for the determination of plasmasphere electron content using Global Positioning System (GPS receivers has provided new opportunities for investigations in that region. This investigation, using a selected chain of GPS stations, extends the method (SCORPION previously applied to a chain of GPS stations in North America in order to separate the ionosphere and plasmasphere contributions to the total electron content (TEC during a day (24 July in 2011. The results span latitudes from the southern tip of Africa, across the Equator, to the southern Arabian Peninsula, providing a continuous latitudinal profile for both the ionosphere and plasmasphere during this day.The peak diurnal vertical ionosphere electron content (IEC increases from about 14 TEC units (1 TEC unit  =  1016 electrons m−2 at the southernmost station to about 32 TEC units near the geographic equator, then decreases to about 28 TEC units at the Arabian Peninsula. The peak diurnal slant plasmasphere electron content (PEC varies between about 4 and 7 TEC units among the stations, with a local latitudinal profile that is significantly influenced by the viewing geometry at the station location, relative to the magnetic field configuration. In contrast, the peak vertical PEC varies between about 1 and 6 TEC units among the stations, with a more uniform latitudinal variation.Comparisons to other GPS data analyses are also presented for TEC, indicating the influence of the PEC on the determination of latitudinal TEC variations and also on the absolute TEC levels, by inducing an overestimate of the receiver bias. The derived TEC latitudinal profiles, in comparison to global map profiles, tend to differ from the map results only about as much as the map results differ among themselves. A combination of ionosonde IEC and alternative GPS TEC measurements, which in principle permits a PEC determination

  15. TEC variability over Havana

    International Nuclear Information System (INIS)

    Lazo, B.; Alazo, K.; Rodriguez, M.; Calzadilla, A.

    2003-01-01

    The variability of total electron content (TEC) measured over Havana using ATS-6, SMS-1 and GOES-3 geosynchronous satellite signals has been investigated for low, middle and high solar activity periods from 1974 to 1982. The obtained results show that standard deviation is smooth during nighttime hours and maximum at noon or postnoon hours. Strong solar activity dependence of standard deviation with a maximum values during HSA has been found. (author)

  16. Global plasmaspheric TEC and its relative contribution to GPS TEC

    Science.gov (United States)

    Yizengaw, E.; Moldwin, M. B.; Galvan, D.; Iijima, B. A.; Komjathy, A.; Mannucci, A. J.

    2008-08-01

    The plasmaspheric electron content is directly estimated from the global positioning system (GPS) data onboard JASON-1 Satellite for the first time. Similarly, the ground-based GPS total electron content (TEC) is estimated using about 1000 GPS receivers distributed around the globe. The relative contribution of the plasmaspheric electron content to the ground-based GPS TEC is then estimated globally using these two independent simultaneous measurements; namely ground-based GPS TEC and JASON-1 GPS TEC. Results presented here include data from 3 months of different solar cycle conditions (October 2003, May 2005, and December 2006). The global comparison between the two independent measurements was performed by dividing the data into three different regions; equatorial, mid- and high-latitude regions. This division is essential as the GPS raypaths traverse different distances through the plasmasphere at different latitudes. The raypath length through the plasmasphere decreases as latitude increases. The relative contribution of the plasmaspheric electron content exhibits a diurnal variation that depends on latitude with minimum contribution (~10%) during daytime and maximum (up to 60%) at night. The contribution is also maximum at the equatorial region where the GPS raypath traverses a long distance through the plasmasphere compared to its length in mid- and high-latitude regions. Finally, the solar cycle variation of plasmaspheric contribution is also reported globally.

  17. Average electron content gradients and nighttime electron fluxes in the mid-latitude ionosphere

    International Nuclear Information System (INIS)

    Ebel, A.; Schmidt, G.; Tauriainen, A.

    1976-01-01

    Observations of the total electron content (TEC) made at Lindau (52 0 N, 10 0 E) by means of low orbiting satellites during the period March 1970 to December 1972 enabled evaluation of the meridional component of the TEC gradient over the station. The behaviour of this component is investigated in connection with the temporal TEC changes using the medians of both quantities. The gradient reflects well known seasonal changes in the ionosphere such as the semiannual anomaly around noon which leads to relatively strong TEC increases towards the south (up to 9 x 10 15 m -2 degree -1 ). For the time shortly after midnight, a second semiannual variation of the gradient shows up with enhanced southward TEC increases. Regular northward ionization increases are found near sunrise in summer. Average TEC increases or markedly reduced decreases during the night were obtained for almost every month during the observation period. This special phenomenon of the nighttime ionosphere is discussed with respect to maximum input fluxes of different kinds, which would be necessary to produce the observed effects. Under normal nighttime conditions, the TEC gradients can lead to changes in the ionization of up to 3 x 10 12 m -2 s -1 due to horizontal plasma transport, when electric fields of reasonable strength (approximately 2 mV/m) are present. (author)

  18. The trend of ionospheric total electron content near the equator ...

    African Journals Online (AJOL)

    The Ionospheric Total Electron Content (TEC) data measured simultaneously by analyzing dual-frequency signals of the Global Position System (GPS) in two northern Nigeria equatorial stations: Ahmadu Bello University Zaria (ABUZ) with geographic latitude (11.16° N) and Longitude(7.65° E) and Birnin Kebbi Polytechnic ...

  19. Online, automatic, near-real time estimation of GPS-TEC: IONOLAB-TEC

    Science.gov (United States)

    Sezen, U.; Arikan, F.; Arikan, O.; Ugurlu, O.; Sadeghimorad, A.

    2013-05-01

    The variability of space weather can best be captured using total electron content (TEC), which corresponds to total number of electrons on a ray path. The dual-frequency ground based GPS receivers provide a cost-effective means for monitoring TEC. Computation of TEC for a single GPS station is a challenge due to various unknowns and ambiguities such as inter-frequency receiver bias and satellite bias, choice of mapping function, and peak height of ionosphere for ionospheric piercing point. In this study, IONOLAB group introduces a robust, automatic, online computation routine near-real time TEC, IONOLAB-TEC, for IGS and/or EUREF stations from www.ionolab.org. The user can choose online one station or multiple stations, date or dates for the computation. The IONOLAB-TEC values can be compared with TEC estimates from IGS analysis centers. The output can be obtained either in graphical form, or IONOLAB-TEC estimates can be provided in an excel file. The service is easy to use with a graphical user interface. This unique and original space weather application is provided online, and IONOLAB-TEC estimates are downloaded automatically to the user defined directories under user defined filenames.

  20. TEC ingestion into NeQuick 2 to model the topside electron density in the East-African ionosphere

    Science.gov (United States)

    Nigussie, M.; Radicella, S. M.; Damtie, B.; Nava, B.; Yizengaw, E.

    2012-12-01

    This study investigates the performances of the NeQuick 2 empirical model in the East-African region by assisting this model with Global Positioning System (GPS) measurements obtained from a single station. First we calculate an effective ionization level that drives NeQuick 2 to reproduce TEC that fits the least square sense to the measurements. We then quantify the performances of the NeQuick 2 in reproducing the topside in situ ion density observed by Communication/ Navigation Outage Forecast System (C/NOFS) satellite after modifying the model's input parameter. This is done by inputting the effective ionization level calculated from the slant total electron content (sTEC) measurements obtained from the single GPS receiver to the model. The performances of the model before and after data ingestion are then investigated by comparing the model results with the topside in situ ion density observation. One-month data during low solar activity conditions were used in this study. We have shown that the capability of NeQuick 2 to specify the East-African region topside ionosphere has been increased substantially by means of data ingestion. We found that the model after ingestion reproduces the in situ topside ion density observations better as far as about 824 km away from the reference station than that before adaptation. In this study, the statistical comparisons of the performances of the model in reproducing topside in situ ion density observations before and after ingestion are also discussed.

  1. Observations in equatorial anomaly region of total electron content enhancements and depletions

    Directory of Open Access Journals (Sweden)

    N. Dashora

    2005-10-01

    Full Text Available A GSV 4004A GPS receiver has been operational near the crest of the equatorial anomaly at Udaipur, India for some time now. The receiver provides the line-of-sight total electron content (TEC, the phase and amplitude scintillation index, σφ and S4, respectively. This paper presents the first results on the nighttime TEC depletions associated with the equatorial spread F in the Indian zone. The TEC depletions are found to be very well correlated with the increased S4 index. A new feature of low-latitude TEC is also reported, concerning the observation of isolated and localized TEC enhancements in the nighttime low-latitude ionosphere. The TEC enhancements are not correlated with the S4 index. The TEC enhancements have also been observed along with the TEC depletions. The TEC enhancements have been interpreted as the manifestation of the plasma density enhancements reported by Le et al. (2003.

    Keywords. Ionosphere (Equatorial ionosphere; Ionospheric irregularities

  2. Clouds and troughs of total electron content detected with the ionospheric weather index

    Science.gov (United States)

    Gulyaeva, Tamara

    2016-07-01

    The ionospheric weather W index has been developed with the different thresholds of change in the F2 layer peak electron density NmF2 (proportional to foF2 critical frequency) or total electron content TEC relative their quiet reference for quantifying the ionosphere variability. The thresholds of DTEC=log(TEC/TECq) are selected for the positive and negative logarithm of TEC ratio to the quiet reference median, TECq, at any given location on the Earth. The global W-index maps are produced from Global Ionospheric Maps of Total Electron Content, GIM-TEC, and provided online at http://www.izmiran.ru/services/iweather/ and http://www.iololab.org/. Based on W-index maps, Catalogues of the ionospheric storms and sub-storms are produced available for the users. The second generation of the ionospheric weather indices, designated V index, is recently introduced and applied for the retrospective study of GIM-TEC variability during 1999-2015. Using sliding-window statistical analysis, moving daily-hourly TEC median TECq for 15 preceding days with estimated variance bounds are obtained at cells of GIM-TEC. The ionosphere variability index, V, is expressed in terms of ΔTEC deviation from the median normalized by the standard deviation STD. V index segmentation is introduced from Vn=-4 in step of 1 to Vp=4 specifying TEC storm if an instant TEC is outside of TECq+-1STD. The global maps of V index allow distinguish the clouds of enhanced TEC (positive storm signatures) and troughs of TEC depletion (negative storm signatures) as compared to the background quiet reference TECq map. It is found that the large-scale TEC clouds and troughs are observed in space all over the world constituting up to 20-50 percent of cells of GIM-TEC. The time variation of these plasma patches is partly following to geomagnetic SSC storm onset. As concerns the interplanetary and the solar wind, SW, sources of the ionospheric storms the TEC storms are observed both with IMF and SW precursors and

  3. Analysis of Total Electron Content and Electron Density Profile during Different Geomagnetic Storms

    Science.gov (United States)

    Chapagain, N. P.; Rana, B.; Adhikari, B.

    2017-12-01

    Total Electron content (TEC) and electron density are the key parameters in the mitigation of ionospheric effects on radio communication system. Detail study of the TEC and electron density variations has been carried out during geomagnetic storms, with longitude and latitude, for four different locations: (13˚N -17˚N, 88˚E -98˚E), (30˚N-50˚N, 120˚W -95˚W), (29˚S-26˚S, 167˚W-163˚W,) and (60˚S-45˚S, 120˚W-105˚W) using the Gravity Recovery and Climate Experiment (GRACE) satellite observations. In order to find the geomagnetic activity, the solar wind parameters such as north-south component of inter planetary magnetic field (Bz), plasma drift velocity (Vsw), flow pressure (nPa), AE, Dst and Kp indices were obtained from Operating Mission as Nodes on the Internet (OMNI) web system. The data for geomagnetic indices have been correlated with the TEC and electron density for four different events of geomagnetic storms on 6 April 2008, 27 March 2008, 4 September 2008, and 11 October 2008. The result illustrates that the observed TEC and electron density profile significantly vary with longitudes and latitudes. This study illustrates that the values of TEC and the vertical electron density profile are influenced by the solar wind parameters associated with solar activities. The peak values of electron density and TEC increase as the geomagnetic storms become stronger. Similarly, the electron density profile varies with altitudes, which peaks around the altitude range of about 250- 350 km, depending on the strength of geomagnetic storms. The results clearly show that the peak electron density shifted to higher altitude (from about 250 km to 350 km) as the geomagnetic disturbances becomes stronger.

  4. Improved estimation of Mars ionosphere total electron content

    Science.gov (United States)

    Cartacci, M.; Sánchez-Cano, B.; Orosei, R.; Noschese, R.; Cicchetti, A.; Witasse, O.; Cantini, F.; Rossi, A. P.

    2018-01-01

    We describe an improved method to estimate the Total Electron Content (TEC) of the Mars ionosphere from the echoes recorded by the Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) (Picardi et al., 2005; Orosei et al., 2015) onboard Mars Express in its subsurface sounding mode. In particular, we demonstrate that this method solves the issue of the former algorithm described at (Cartacci et al., 2013), which produced an overestimation of TEC estimates on the day side. The MARSIS signal is affected by a phase distortion introduced by the Mars ionosphere that produces a variation of the signal shape and a delay in its travel time. The new TEC estimation is achieved correlating the parameters obtained through the correction of the aforementioned effects. In detail, the knowledge of the quadratic term of the phase distortion estimated by the Contrast Method (Cartacci et al., 2013), together with the linear term (i.e. the extra time delay), estimated through a radar signal simulator, allows to develop a new algorithm particularly well suited to estimate the TEC for solar zenith angles (SZA) lower than 95° The new algorithm for the dayside has been validated with independent data from MARSIS in its Active Ionospheric Sounding (AIS) operational mode, with comparisons with other previous algorithms based on MARSIS subsurface data, with modeling and with modeling ionospheric distortion TEC reconstruction.

  5. Performance evaluation of linear time-series ionospheric Total Electron Content model over low latitude Indian GPS stations

    Science.gov (United States)

    Dabbakuti, J. R. K. Kumar; Venkata Ratnam, D.

    2017-10-01

    Precise modeling of the ionospheric Total Electron Content (TEC) is a critical aspect of Positioning, Navigation, and Timing (PNT) services intended for the Global Navigation Satellite Systems (GNSS) applications as well as Earth Observation System (EOS), satellite communication, and space weather forecasting applications. In this paper, linear time series modeling has been carried out on ionospheric TEC at two different locations at Koneru Lakshmaiah University (KLU), Guntur (geographic 16.44° N, 80.62° E; geomagnetic 7.55° N) and Bangalore (geographic 12.97° N, 77.59° E; geomagnetic 4.53° N) at the northern low-latitude region, for the year 2013 in the 24th solar cycle. The impact of the solar and geomagnetic activity on periodic oscillations of TEC has been investigated. Results confirm that the correlation coefficient of the estimated TEC from the linear model TEC and the observed GPS-TEC is around 93%. Solar activity is the key component that influences ionospheric daily averaged TEC while periodic component reveals the seasonal dependency of TEC. Furthermore, it is observed that the influence of geomagnetic activity component on TEC is different at both the latitudes. The accuracy of the model has been assessed by comparing the International Reference Ionosphere (IRI) 2012 model TEC and TEC measurements. Moreover, the absence of winter anomaly is remarkable, as determined by the Root Mean Square Error (RMSE) between the linear model TEC and GPS-TEC. On the contrary, the IRI2012 model TEC evidently failed to predict the absence of winter anomaly in the Equatorial Ionization Anomaly (EIA) crest region. The outcome of this work will be useful for improving the ionospheric now-casting models under various geophysical conditions.

  6. Adjustments of the TaD electron density reconstruction model with GNSS-TEC parameters for operational application purposes

    Directory of Open Access Journals (Sweden)

    Belehaki Anna

    2012-12-01

    Full Text Available Validation results on the latest version of TaD model (TaDv2 show realistic reconstruction of the electron density profiles (EDPs with an average error of 3 TECU, similar to the error obtained from GNSS-TEC calculated paremeters. The work presented here has the aim to further improve the accuracy of the TaD topside reconstruction, adjusting the TEC parameter calculated from TaD model with the TEC parameter calculated by GNSS transmitting RINEX files provided by receivers co-located with the Digisondes. The performance of the new version is tested during a storm period demonstrating further improvements in respect to the previous version. Statistical comparison of modeled and observed TEC confirms the validity of the proposed adjustment. A significant benefit of the proposed upgrade is that it facilitates the real-time implementation of TaD. The model needs a reliable measure of the scale height at the peak height, which is supposed to be provided by Digisondes. Oftenly, the automatic scaling software fails to correctly calculate the scale height at the peak, Hm, due to interferences in the receiving signal. Consequently the model estimated topside scale height is wrongly calculated leading to unrealistic results for the modeled EDP. The proposed TEC adjustment forces the model to correctly reproduce the topside scale height, despite the inaccurate values of Hm. This adjustment is very important for the application of TaD in an operational environment.

  7. Ionospheric total electron content: Spatial patterns of variability

    Science.gov (United States)

    Lean, J. L.; Meier, R. R.; Picone, J. M.; Sassi, F.; Emmert, J. T.; Richards, P. G.

    2016-10-01

    The distinctive spatial patterns of the ionosphere's total electron content (TEC) response to solar, seasonal, diurnal, and geomagnetic influences are determined across the globe using a new statistical model constructed from 2-hourly TEC observations from 1998 to 2015. The model combines representations of the physical solar EUV photon and geomagnetic activity drivers with solar-modulated sinusoidal parameterizations of four seasonal cycles and solar-modulated and seasonally modulated parameterizations of three diurnal cycles. The average absolute residual of the data-model differences is 2.1 total electron content unit, 1 TECU = 1016 el m-2 (TECU) (9%) and the root-mean-square error is 3.5 TECU (15%). Solar and geomagnetic variability, the semiannual oscillation and the diurnal and semidiurnal oscillations all impact TEC most at low magnetic latitudes where TEC itself maximizes, with differing degrees of longitudinal inhomogeneity. In contrast, the annual oscillation manifests primarily in the Southern Hemisphere with maximum amplitude over midlatitude South America, extending to higher southern latitudes in the vicinity of the Weddell Sea. Nighttime TEC levels in the vicinity of the Weddell Sea exceed daytime levels every year in Southern Hemisphere summer as a consequence of the modulation of the diurnal oscillations by the seasonal oscillations. The anomaly, which is present at all phases of the solar cycle, commences sooner and ends later under solar minimum conditions. The model minus data residuals maximize at tropical magnetic latitudes in four geographical regions similar to the ionosphere pattern generated by lower atmospheric meteorology. Enhanced residuals at northern midlatitudes during winter are consistent with an influence of atmospheric gravity waves.

  8. Application of Kalman filter in detecting pre-earthquake ionospheric TEC anomaly

    Directory of Open Access Journals (Sweden)

    Zhu Fuying

    2011-05-01

    Full Text Available : As an attempt, the Kalman filter was used to study the anomalous variations of ionospheric Total Electron Content (TEC before and after Wenchuan Ms8.0 earthquake, these TEC data were calculated from the GPS data observed by the Crustal Movement Observation Network of China. The result indicates that this method is reasonable and reliable in detecting TEC anomalies associated with large earthquakes.

  9. Long-term analysis of ionospheric polar patches based on CHAMP TEC data

    DEFF Research Database (Denmark)

    Noja, M.; Stolle, Claudia; Park, J.

    2013-01-01

    Total electron content (TEC) from LEO satellites offers great possibility to sound the upper ionosphere and plasmasphere. This paper describes a method to derive absolute TEC observations aboard CHAMP considering multipath effects and receiver differential code bias. The long-term data set of 9...... that enhanced TEC at midlatitudes and low latitudes during December solstice provides a greater possibility to transport high-density plasma to the polar region through the buildup of TOIs. ©2013. American Geophysical Union. All Rights Reserved....

  10. Comparison of EUV Brightness With Line-of-Sight Total Electron Content in the Earth's Plasmasphere.

    Science.gov (United States)

    Galvan, D. A.; Yizengaw, E.; Moldwin, M. B.; Hajj, G.; Mannucci, T.; Sandel, B.

    2007-05-01

    Total electron content (TEC) data, obtained from radio signals sent between the Jason-1 satellite in low-Earth- orbit (LEO) and global positioning system (GPS) satellites, are inverted using tomography to infer electron density in Jason-1's orbital plane. We then construct column density traces along the lines of sight of an extreme ultraviolet (EUV) image of the He+ population of the plasmasphere, taken by NASA's IMAGE spacecraft. In this way, we produce column integrated electron density (TEC) values aligned with IMAGE's lines of sight. Since singly-ionized helium in the plasmasphere is optically thin, the radiance of an EUV image pixel is proportional to the column-integrated density of He+ ions along the line of sight. Hence, a TEC measurement gives us a column-integrated electron density, while an EUV image brightness value is proportional to a column-integrated He+ density. By comparing the radial brightness profile from an EUV image to the line-of-sight TEC in Jason's orbital plane, we can gain insight into the behavior of He+ and electron density in the plasmasphere. Future comparisons between TEC and EUV data could lead to an improved, three-dimensional, empirical model of plasmaspheric electron density, and a better understanding of IMAGE EUV images themselves.

  11. On forecasting ionospheric total electron content responses to high-speed solar wind streams

    Directory of Open Access Journals (Sweden)

    Meng Xing

    2016-01-01

    Full Text Available Conditions in the ionosphere have become increasingly important to forecast, since more and more spaceborne and ground-based technological systems rely on ionospheric weather. Here we explore the feasibility of ionospheric forecasts with the current generation of physics-based models. In particular, we focus on total electron content (TEC predictions using the Global Ionosphere-Thermosphere Model (GITM. Simulations are configured in a forecast mode and performed for four typical high-speed-stream events during 2007–2012. The simulated TECs are quantified through a metric, which divides the globe into a number of local regions and robustly differentiates between quiet and disturbed periods. Proposed forecast products are hourly global maps color-coded by the TEC disturbance level of each local region. To assess the forecasts, we compare the simulated TEC disturbances with global TEC maps derived from Global Positioning System (GPS satellite observations. The forecast performance is found to be merely acceptable, with a large number of regions where the observed variations are not captured by the simulations. Examples of model-data agreements and disagreements are investigated in detail, aiming to understand the model behavior and improve future forecasts. For one event, we identify two adjacent regions with similar TEC observations but significant differences in how local chemistry versus plasma transport contribute to electron density changes in the simulation. Suggestions for further analysis are described.

  12. GPS Receiver and Satellite DCB Estimation using Ionospheric TEC

    OpenAIRE

    Byung-Kyu Choi; Sung-Ki Cho; Sang-Jeong Lee

    2009-01-01

    We estimated the receiver and satellite differential code bias (DCB) based on the ionospheric total electron content (TEC) estimation method. The GPS network which has been operated by the Korea Astronomy and Space Science Institute (KASI) was designed to calculate TEC. The receiver and satellite DCB values were obtained from the weighted least square method with time interval for one hour. The results represented that the receiver DCB values are mostly varying within ±2 meter and are derived...

  13. Global navigation satellite system detection of preseismic ionospheric total electron content anomalies for strong magnitude (Mw>6) Himalayan earthquakes

    Science.gov (United States)

    Sharma, Gopal; Champati ray, Prashant Kumar; Mohanty, Sarada; Gautam, Param Kirti Rao; Kannaujiya, Suresh

    2017-10-01

    Electron content in the ionosphere is very sensitive to temporary disturbances of the Earth's magnetosphere (geomagnetic storm), solar flares, and seismic activities. The Global Navigation Satellite System (GNSS)-based total electron content (TEC) measurement has emerged as an important technique for computations of earthquake precursor signals. We examined the pre-earthquake signatures for eight strong magnitude (Mw>6: 6.1 to 7.8) earthquakes with the aid of GNSS-based TEC measurement in the tectonically active Himalayan region using International GNSS Service (IGS) stations as well as local GNSS-based continuously operating reference stations (CORS). The results indicate very significant ionospheric anomalies in the vertical total electron content (vTEC) a few days before the main shock for all of the events. Geomagnetic activities were also studied during the TEC observation window to ascertain their role in ionospheric perturbations. It was also inferred that TEC variation due to low magnitude events could also be monitored if the epicenter lies closer to the GNSS or IGS station. Therefore, the study has confirmed TEC anomalies before major Himalayan earthquakes, thereby making it imperative to set up a much denser network of IGS/CORS for real-time data analysis and forewarning.

  14. Unbiased total electron content (UTEC), their fluctuations, and correlation with seismic activity over Japan

    Science.gov (United States)

    Cornely, Pierre-Richard; Hughes, John

    2018-02-01

    Earthquakes are among the most dangerous events that occur on earth and many scientists have been investigating the underlying processes that take place before earthquakes occur. These investigations are fueling efforts towards developing both single and multiple parameter earthquake forecasting methods based on earthquake precursors. One potential earthquake precursor parameter that has received significant attention within the last few years is the ionospheric total electron content (TEC). Despite its growing popularity as an earthquake precursor, TEC has been under great scrutiny because of the underlying biases associated with the process of acquiring and processing TEC data. Future work in the field will need to demonstrate our ability to acquire TEC data with the least amount of biases possible thereby preserving the integrity of the data. This paper describes a process for removing biases using raw TEC data from the standard Rinex files obtained from any global positioning satellites system. The process is based on developing an unbiased TEC (UTEC) data and model that can be more adaptable to serving as a precursor signal for earthquake forecasting. The model was used during the days and hours leading to the earthquake off the coast of Tohoku, Japan on March 11, 2011 with interesting results. The model takes advantage of the large amount of data available from the GPS Earth Observation Network of Japan to display near real-time UTEC data as the earthquake approaches and for a period of time after the earthquake occurred.

  15. Case study on total electron content enhancements at low latitudes during low geomagnetic activities before the storms

    Directory of Open Access Journals (Sweden)

    Libo Liu

    2008-05-01

    Full Text Available Sometimes the ionospheric total electron content (TEC is significantly enhanced during low geomagnetic activities before storms. In this article, we investigate the characteristics of those interesting TEC enhancements using regional and global TEC data. We analyzed the low-latitude TEC enhancement events that occurred around longitude 120° E on 10 February 2004, 21 January 2004, and 4 March 2001, respectively. The TEC data are derived from regional Global Positioning System (GPS observations in the Asia/Australia sector as well as global ionospheric maps (GIMs produced by Jet Propulsion Laboratory (JPL. Strong enhancements under low geomagnetic activity before the storms are simultaneously presented at low latitudes in the Asia/Australia sector in regional TEC and JPL GIMs. These TEC enhancements are shown to be regional events with longitudinal and latitudinal extent. The regions of TEC enhancements during these events are confined at narrow longitude ranges around longitude 120° E. The latitudinal belts of maxima of enhancements locate around the northern and southern equatorial ionization anomaly (EIA crests, which are consistent with those low-latitude events presented by Liu et al. (2008. During the 4 March 2001 event, the total plasma density Ni observed by the Defense Meteorological Satellite Program (DMSP spacecraft F13 at 840 km altitude are of considerably higher values on 4 March than on the previous day in the TEC enhanced regions. Some TEC enhancement events are possibly due to contributions from auroral/magnetospheric origins; while there are also quasi-periodic enhancement events not related to geomagnetic activity and associated probably with planetary wave type oscillations (e.g. the 6 January 1998 event. Further investigation is warrented to identify/separate contributions from possible sources.

  16. Total electron content responses to HILDCAAs and geomagnetic storms over South America

    Science.gov (United States)

    Mara de Siqueira Negreti, Patricia; Rodrigues de Paula, Eurico; Nicoli Candido, Claudia Maria

    2017-12-01

    Total electron content (TEC) is extensively used to monitor the ionospheric behavior under geomagnetically quiet and disturbed conditions. This subject is of greatest importance for space weather applications. Under disturbed conditions the two main sources of electric fields, which are responsible for changes in the plasma drifts and for current perturbations, are the short-lived prompt penetration electric fields (PPEFs) and the longer-lasting ionospheric disturbance dynamo (DD) electric fields. Both mechanisms modulate the TEC around the globe and the equatorial ionization anomaly (EIA) at low latitudes. In this work we computed vertical absolute TEC over the low latitude of South America. The analysis was performed considering HILDCAA (high-intensity, long-duration, continuous auroral electrojet (AE) activity) events and geomagnetic storms. The characteristics of storm-time TEC and HILDCAA-associated TEC will be presented and discussed. For both case studies presented in this work (March and August 2013) the HILDCAA event follows a geomagnetic storm, and then a global scenario of geomagnetic disturbances will be discussed. Solar wind parameters, geomagnetic indices, O / N2 ratios retrieved by GUVI instrument onboard the TIMED satellite and TEC observations will be analyzed and discussed. Data from the RBMC/IBGE (Brazil) and IGS GNSS networks were used to calculate TEC over South America. We show that a HILDCAA event may generate larger TEC differences compared to the TEC observed during the main phase of the precedent geomagnetic storm; thus, a HILDCAA event may be more effective for ionospheric response in comparison to moderate geomagnetic storms, considering the seasonal conditions. During the August HILDCAA event, TEC enhancements from ˜ 25 to 80 % (compared to quiet time) were observed. These enhancements are much higher than the quiet-time variability observed in the ionosphere. We show that ionosphere is quite sensitive to solar wind forcing and

  17. Latitudinal and Seasonal Investigations of Storm-Time TEC Variation

    Science.gov (United States)

    Adimula, I. A.; Oladipo, O. A.; Adebiyi, S. J.

    2016-07-01

    The ionosphere responds markedly and unpredictably to varying magnetospheric energy inputs caused by solar disturbances on the geospace. Knowledge of the impact of the space weather events on the ionosphere is important to assess the environmental effect on the operations of ground- and space-based technologies. Thus, global positioning system (GPS) measurements from the international GNSS service (IGS) database were used to investigate the ionospheric response to 56 geomagnetic storm events at six different latitudes comprising the northern and southern hemispheres in the Afro-European sector. Statistical distributions of total electron content (TEC) response show that during the main phase of the storms, enhancement of TEC is more pronounced in most of the seasons, regardless of the latitude and hemisphere. However, a strong seasonal dependence appears in the TEC response during the recovery phase. Depletion of TEC is majorly observed at the high latitude stations, and its appearance at lower latitudes is seasonally dependent. In summer hemisphere, the depletion of TEC is more pronounced in nearly all the latitudinal bands. In winter hemisphere, enhancement as well as depletion of TEC is observed over the high latitude, while enhancement is majorly observed over the mid and low latitudes. In equinoxes, the storm-time TEC distribution shows a fairly consistent characteristic with the summer distribution, particularly in the northern hemisphere.

  18. Calculations of the Total Number of Electrons Along a Ray Path Extending from the Transmitter to the Receiver

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Ionospheric Total Electron Content (TEC) is the total number of electrons in a column of unit cross section extending from the transmitter to the receiver. TEC is...

  19. GPS Receiver and Satellite DCB Estimation using Ionospheric TEC

    Science.gov (United States)

    Choi, Byung-Kyu; Cho, Sung-Ki; Lee, Sang-Jeong

    2009-06-01

    We estimated the receiver and satellite differential code bias (DCB) based on the ionospheric total electron content (TEC) estimation method. The GPS network which has been operated by the Korea Astronomy and Space Science Institute (KASI) was designed to calculate TEC. The receiver and satellite DCB values were obtained from the weighted least square method with time interval for one hour. The results represented that the receiver DCB values are mostly varying within ±2 meter and are derived comparatively stable within three days. The estimated mean values of the satellite DCB show the maximum and minimum values of 4.09 nano-second (ns), --6.28ns respectively. We could detect great variations of TEC over 9 TECU difference at any time when the DCB sets were applied to TEC estimation.

  20. GPS Receiver and Satellite DCB Estimation using Ionospheric TEC

    Directory of Open Access Journals (Sweden)

    Byung-Kyu Choi

    2009-06-01

    Full Text Available We estimated the receiver and satellite differential code bias (DCB based on the ionospheric total electron content (TEC estimation method. The GPS network which has been operated by the Korea Astronomy and Space Science Institute (KASI was designed to calculate TEC. The receiver and satellite DCB values were obtained from the weighted least square method with time interval for one hour. The results represented that the receiver DCB values are mostly varying within ±2 meter and are derived comparatively stable within three days. The estimated mean values of the satellite DCB show the maximum and minimum values of 4.09 nano-second (ns, --6.28ns respectively. We could detect great variations of TEC over 9 TECU difference at any time when the DCB sets were applied to TEC estimation.

  1. Features of TEC behaviour over the low-latitude North-American region during the period of medium solar activity

    Science.gov (United States)

    Sergeeva, M. A.; Maltseva, O. A.; Gonzalez-Esparza, J. A.; De la Luz, V.; Corona-Romero, P.

    2017-10-01

    The study is focused on Total Electron Content (TEC) behavior in low-latitude North-American region within the twelve-year period from 2005 to 2016. The obtained systematic (regular) TEC variations (diurnal, seasonal patterns) conform to the known tendencies described by climatological TEC models. TEC variations during disturbances have a number of distinctive features. The majority of positive TEC enhancements occur already with Dst Dst-index minimum value. Almost all cases of day-time TEC disturbances are accompanied by night-time disturbances with the possibility of relative night-time deviations being larger that is confirmed by data of low-orbit satellites CHAMP and DMSP. The simultaneity of changes of critical frequencies of the ionosphere with changes of TEC during disturbances was observed at Ramey (Puerto Rico) and Eglin (U.S.A.) stations when ionosonde data was available. This proves that TEC reflects the character of ionospheric disturbances. Spatial non-synchronism of TEC change that was sometimes observed can be explained by local character of the area covered with positive TEC disturbance. It was shown the potential provided by local GNSS networks for the detailed analysis of TEC variations over the considered region and estimation of the ionosphere state in near-real time.

  2. Using tomography of GPS TEC to routinely determine ionospheric average electron density profiles

    Science.gov (United States)

    Yizengaw, E.; Moldwin, M. B.; Dyson, P. L.; Essex, E. A.

    2007-03-01

    This paper introduces a technique that calculates average electron density (Ne) profiles over a wide geographic area of coverage, using tomographic ionospheric Ne profiles. These Ne profiles, which can provide information of the Ne distribution up to global positioning system (GPS) orbiting altitude (with the coordination of space-based GPS tomographic profiles), can be incorporated into the next generation of the international reference ionosphere (IRI) model. An additional advantage of tomography is that it enables accurate modeling of the topside ionosphere. By applying the tomographic reconstruction approach to ground-based GPS slant total electron content (STEC), we calculate 3-h average Ne profiles over a wide region. Since it uses real measurement data, tomographic average Ne profiles describe the ionosphere during quiet and disturbed periods. The computed average Ne profiles are compared with IRI model profiles and average Ne profiles obtained from ground-based ionosondes.

  3. Temporal and spatial precursors in ionospheric total electron content of the 16 October 1999 Mw7.1 Hector Mine earthquake

    Science.gov (United States)

    Su, Y. C.; Liu, J. Y.; Chen, S. P.; Tsai, H. F.; Chen, M. Q.

    2013-10-01

    this paper, temporal and spatial analyses are employed to detect seismo-ionospheric precursors (SIPs) in the ionospheric total electron content (TEC) during the 16 October 1999 Mw7.1 Hector Mine earthquake. To discriminate anomalies caused by global effects, such as solar radiations, magnetic storms, etc., and local effects, such as earthquake, we cross-examine the GPS TECs and their gradients in the eastward and northward directions at epicenter/centers of the Hector Mine area and the other two reference areas at similar magnetic latitudes in Europe and Japan. Temporal variations of the northward TEC gradient suggest SIPs most likely appearing on days 6-5 before the earthquake. A global search by using the TEC of the global ionosphere map shows that the TEC increase and decrease anomalies continuously and specifically appear around the epicenter on day 5 before the earthquake.

  4. Seismo-ionospheric Precursors in the GPS Total Electron Content of the 16 October 1999 Mw7.1 Hector Mine Earthquake

    Science.gov (United States)

    Tsai, H.; Su, Y.; Liu, J. G.; Chen, S.; Chen, M.

    2013-12-01

    In this paper, temporal and spatial analyses are employed to detect seismo-ionospheric precursors (SIPs) in the ionospheric total electron content (TEC) during 16 October 1999 Mw7.1 Hector Mine earthquake. To discriminate anomalies caused by global effects, such as solar radiations, magnetic storms, etc., and local effects, such as earthquake, we cross-examine the GPS TECs and their gradients in the eastward and northward directions at epicenter/centers of the Hector Mine area and the other two reference areas at similar magnetic latitudes in Europe and Japan. Temporal variations of the northward TEC gradient suggest SIPs most likely appearing day 6-5 before the earthquake. A global search by using the TEC of GIM (global ionosphere map) shows that the TEC increase and decrease anomalies continuously and specifically appear around the epicenter day 5 before the earthquake.

  5. Observing Traveling Ionospheric Disturbances Caused by Tsunamis Using GPS TEC Measurements

    Science.gov (United States)

    Galvan, David A.; Komjathy, Attila; Hickey, Michael; Foster, James; Mannucci, Anthony J.

    2010-01-01

    Ground-based Global Positioning System (GPS) measurements of ionospheric Total Electron Content (TEC) show variations consistent with atmospheric internal gravity waves caused by ocean tsunamis following two recent seismic events: the American Samoa earthquake of September 29, 2009, and the Chile earthquake of February 27, 2010. Fluctuations in TEC correlated in time, space, and wave properties with these tsunamis were observed in TEC estimates processed using JPL's Global Ionospheric Mapping Software. These TEC estimates were band-pass filtered to remove ionospheric TEC variations with wavelengths and periods outside the typical range of internal gravity waves caused by tsunamis. Observable variations in TEC appear correlated with the tsunamis in certain locations, but not in others. Where variations are observed, the typical amplitude tends to be on the order of 1% of the background TEC value. Variations with amplitudes 0.1 - 0.2 TECU are observable with periods and timing affiliated with the tsunami. These observations are compared to estimates of expected tsunami-driven TEC variations produced by Embry Riddle Aeronautical University's Spectral Full Wave Model, an atmosphere-ionosphere coupling model, and found to be in good agreement in some locations, though there are cases when the model predicts an observable tsunami-driven signature and none is observed. These TEC variations are not always seen when a tsunami is present, but in these two events the regions where a strong ocean tsunami was observed did coincide with clear TEC observations, while a lack of clear TEC observations coincided with smaller tsunami amplitudes. There exists the potential to apply these detection techniques to real-time GPS TEC data, providing estimates of tsunami speed and amplitude that may be useful for early warning systems.

  6. Informal report on measurements of slant TEC by FORTE

    International Nuclear Information System (INIS)

    Massey, R.S.

    1997-01-01

    Los Alamos National Laboratory's Space and Atmospheric Sciences group is now operating the FORTE satellite, which has two sets of instruments: optical detectors and radio detectors. In this report the author describes work with one set of radio detectors that allow measurements of the total electron content (TEC) traversed by VHF radiation originating at an electromagnetic pulse (EMP) generator located at Los Alamos

  7. Measuring GNSS ionospheric total electron content at Concordia, and application to L-band radiometers

    Directory of Open Access Journals (Sweden)

    Vincenzo Romano

    2013-06-01

    Full Text Available In the framework of the project BIS - Bipolar Ionospheric Scintillation and Total Electron Content Monitoring, the ISACCO-DMC0 and ISACCO-DMC1 permanent monitoring stations were installed in 2008. The principal scope of the stations is to measure the ionospheric total electron content (TEC and to monitor the ionospheric scintillations, using high-sampling-frequency global positioning system (GPS ionospheric scintillation and TEC monitor (GISTM receivers. The disturbances that the ionosphere can induce on the electromagnetic signals emitted by the Global Navigation Satellite System constellations are due to the presence of electron density anomalies in the ionosphere, which are particularly frequent at high latitudes, where the upper atmosphere is highly sensitive to perturbations coming from outer space. With the development of present and future low-frequency space-borne microwave missions (e.g., Soil Moisture and Ocean Salinity [SMOS], Aquarius, and Soil Moisture Active Passive missions, there is an increasing need to estimate the effects of the ionosphere on the propagation of electromagnetic waves that affects satellite measurements. As an example, how the TEC data collected at Concordia station are useful for the calibration of the European Space Agency SMOS data within the framework of an experiment promoted by the European Space Agency (known as DOMEX will be discussed. The present report shows the ability of the GISTM station to monitor ionospheric scintillation and TEC, which indicates that only the use of continuous GPS measurements can provide accurate information on TEC variability, which is necessary for continuous calibration of satellite data.

  8. Comparison of temporal fluctuations in the total electron content estimates from EISCAT and GPS along the same line of sight

    Directory of Open Access Journals (Sweden)

    B. Forte

    2013-04-01

    Full Text Available The impact of space weather events on satellite-based technologies (e.g. satellite navigation and precise positioning is typically quantified on the basis of the total electron content (TEC and temporal fluctuations associated with it. GNSS (global navigation satellite systems TEC measurements are integrated over a long distance and thus may include contributions from different regions of the ionised atmosphere which may prevent the resolution of the mechanisms ultimately responsible for given observations. The purpose of the experiment presented here was to compare TEC estimates from EISCAT and GPS measurements. The EISCAT measurements were obtained along the same line of sight of a given GPS satellite observed from Tromsø. The present analyses focussed on the comparison of temporal fluctuations in the TEC between aligned GPS and EISCAT measurements. A reasonably good agreement was found between temporal fluctuations in TEC observed by EISCAT and those observed by a co-located GPS ionospheric monitor along the same line of sight, indicating a contribution from structures at E and F altitudes mainly to the total TEC in the presence of ionisation enhancements possibly caused by particle precipitation in the nighttime sector. The experiment suggests the great potential in the measurements to be performed by the future EISCAT_3D system, limited only in the localised geographic region to be covered.

  9. Comparison of mapped and measured total ionospheric electron content using global positioning system and beacon satellite observations

    International Nuclear Information System (INIS)

    Lanyi, G.E.; Roth, T.

    1988-01-01

    Total ionospheric electron contents (TEC) were measured by global positioning system (GPS) dual-frequency receivers developed by the Jet Propulsion Laboratory. The measurements included P-code (precise ranging code) and carrier phase data for six GPS satellites during multiple five-hour observing sessions. A set of these GPS TEC measurements were mapped from the GPS lines of sight to the line of sight of a Faraday beacon satellite by statistically fitting the TEC data to a simple model of the ionosphere. The mapped GPS TEC values were compared with the Faraday rotation measurements. Because GPS transmitter offsets are different for each satellite and because some GPS receiver offsets were uncalibrated, the sums of the satellite and receiver offsets were estimated simultaneously with the TEC in a least squares procedure. The accuracy of this estimation procedure is evaluated indicating that the error of the GPS-determined line of sight TEC can be at or below 1 x 10 to the 16th el/sq cm. Consequently, the current level of accuracy is comparable to the Faraday rotation technique; however, GPS provides superior sky coverage. 15 references

  10. GNSS Derived Ionospheric TEC Observed Through Different TEC Calibration Techniques in the Brazilian Sector

    Science.gov (United States)

    Becker-Guedes, F.; Carmo, C. S.; Camargo, P. O.; Monico, J. F. G.; Nicoli Candido, C. M.

    2017-12-01

    Global Navigation Satellite System (GNSS) is becoming a reliable tool for use in air navigation systems. Its use as the main technology for determination of airplanes positioning has various economic and logistic benefits but it depends strongly on the ionospheric layer influences. The Brazilian sector ionosphere, mainly over the equatorial ionization anomaly (EIA), presents remarkable errors in the GNSS signal as compared to North America and Europe. In order to study the total electron content latitudinal variation of the Brazilian ionosphere we used a pair of GNSS receivers on the ground, one located in the equatorial region (Sao Luis) and other in the southern crest of the EIA (Cachoeira Paulista), to collect the GNSS observables and calculate the vertical TEC using different methods that has proven to work well to describe the ionospheric behavior in the North America and in Europe. We compared this results with a modified Nagoya TEC calculation method used by the EMBRACE (Estudo e Monitoramento BRAsileiro do Clima Espacial - Brazilian Study and Monitoring of Space Weather) program. This work intends to follow the performance of different TEC tuning methods to evaluate the spurious effects of the ionospheric EIA gradients in the TEC determination under typical conditions of the low-latitudes ionosphere in the Brazilian sector. The calculated TEC under different solar cycle conditions, geomagnetic activity, and seasonal variations show deviations in the performance of each method and stress the importance of well adjust the GNSS observations to local conditions in order to optimize the TEC evaluation. This study contributes to a better understanding of local GNSS signal errors in the global intent of offering conditions to improve the accuracy, integrity, availability, and continuity requirements for the use of GNSS for air navigation in South America.

  11. Ionospheric TEC Weather Map Over South America

    Science.gov (United States)

    Takahashi, H.; Wrasse, C. M.; Denardini, C. M.; Pádua, M. B.; de Paula, E. R.; Costa, S. M. A.; Otsuka, Y.; Shiokawa, K.; Monico, J. F. Galera; Ivo, A.; Sant'Anna, N.

    2016-11-01

    Ionospheric weather maps using the total electron content (TEC) monitored by ground-based Global Navigation Satellite Systems (GNSS) receivers over South American continent, TECMAP, have been operationally produced by Instituto Nacional de Pesquisas Espaciais's Space Weather Study and Monitoring Program (Estudo e Monitoramento Brasileiro de Clima Especial) since 2013. In order to cover the whole continent, four GNSS receiver networks, (Rede Brasileiro de Monitoramento Contínuo) RBMC/Brazilian Institute for Geography and Statistics, Low-latitude Ionospheric Sensor Network, International GNSS Service, and Red Argentina de Monitoreo Satelital Continuo, in total 140 sites, have been used. TECMAPs with a time resolution of 10 min are produced in 12 h time delay. Spatial resolution of the map is rather low, varying between 50 and 500 km depending on the density of the observation points. Large day-to-day variabilities of the equatorial ionization anomaly have been observed. Spatial gradient of TEC from the anomaly trough (total electron content unit, 1 TECU = 1016 el m-2 (TECU) 80) causes a large ionospheric range delay in the GNSS positioning system. Ionospheric plasma bubbles, their seeding and development, could be monitored. This plasma density (spatial and temporal) variability causes not only the GNSS-based positioning error but also radio wave scintillations. Monitoring of these phenomena by TEC mapping becomes an important issue for space weather concern for high-technology positioning system and telecommunication.

  12. Empirical models of Total Electron Content based on functional fitting over Taiwan during geomagnetic quiet condition

    Directory of Open Access Journals (Sweden)

    Y. Kakinami

    2009-08-01

    Full Text Available Empirical models of Total Electron Content (TEC based on functional fitting over Taiwan (120° E, 24° N have been constructed using data of the Global Positioning System (GPS from 1998 to 2007 during geomagnetically quiet condition (Dst>−30 nT. The models provide TEC as functions of local time (LT, day of year (DOY and the solar activity (F, which are represented by 1–162 days mean of F10.7 and EUV. Other models based on median values have been also constructed and compared with the models based on the functional fitting. Under same values of F parameter, the models based on the functional fitting show better accuracy than those based on the median values in all cases. The functional fitting model using daily EUV is the most accurate with 9.2 TECu of root mean square error (RMS than the 15-days running median with 10.4 TECu RMS and the model of International Reference Ionosphere 2007 (IRI2007 with 14.7 TECu RMS. IRI2007 overestimates TEC when the solar activity is low, and underestimates TEC when the solar activity is high. Though average of 81 days centered running mean of F10.7 and daily F10.7 is often used as indicator of EUV, our result suggests that average of F10.7 mean from 1 to 54 day prior and current day is better than the average of 81 days centered running mean for reproduction of TEC. This paper is for the first time comparing the median based model with the functional fitting model. Results indicate the functional fitting model yielding a better performance than the median based one. Meanwhile we find that the EUV radiation is essential to derive an optimal TEC.

  13. Observational Analysis of Variation Characteristics of GPS-Based TEC Fluctuation over China

    Directory of Open Access Journals (Sweden)

    Xifeng Liu

    2016-12-01

    Full Text Available In this study, the characteristics of the total electron content (TEC fluctuations and their regional differences over China were analyzed by utilizing the rate of the TEC index (ROTI based on GPS data from 21 reference stations across China during a solar cycle. The results show that there were significant regional differences at different latitudes. Strong ionospheric TEC fluctuations were usually observed at lower latitudes in southern China, where the occurrence of TEC fluctuations demonstrated typical nighttime- and season-dependent (equinox months features. This phenomenon was consistent with the ionospheric scintillation characteristics of this region. Additionally, compared to low-latitude China, the intensity of TEC fluctuations over mid-latitude China was significantly weaker, and the occurrence of TEC fluctuations was not a nighttime-dependent phenomenon. Moreover, the intensity of TEC fluctuations was much stronger during high solar activity than during low solar activity. Furthermore, the summer-dependent characteristics of TEC fluctuations gradually emerged over lower mid-latitude areas as equinox characteristics weakened. Similar to the equinox characteristics, the summer-dependent characteristics gradually weakened or even disappeared with the increasing latitude. Relevant discussions of this phenomenon are still relatively rare, and it requires further study and analysis.

  14. Long-term prediction of the Arctic ionospheric TEC based on time-varying periodograms.

    Science.gov (United States)

    Liu, Jingbin; Chen, Ruizhi; Wang, Zemin; An, Jiachun; Hyyppä, Juha

    2014-01-01

    Knowledge of the polar ionospheric total electron content (TEC) and its future variations is of scientific and engineering relevance. In this study, a new method is developed to predict Arctic mean TEC on the scale of a solar cycle using previous data covering 14 years. The Arctic TEC is derived from global positioning system measurements using the spherical cap harmonic analysis mapping method. The study indicates that the variability of the Arctic TEC results in highly time-varying periodograms, which are utilized for prediction in the proposed method. The TEC time series is divided into two components of periodic oscillations and the average TEC. The newly developed method of TEC prediction is based on an extrapolation method that requires no input of physical observations of the time interval of prediction, and it is performed in both temporally backward and forward directions by summing the extrapolation of the two components. The backward prediction indicates that the Arctic TEC variability includes a 9 years period for the study duration, in addition to the well-established periods. The long-term prediction has an uncertainty of 4.8-5.6 TECU for different period sets.

  15. Behaviour of electron content in the ionospheric D-region during solar X-ray flares

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    Todorović-Drakul M.

    2016-01-01

    Full Text Available One of the most important parameters in ionospheric plasma research, also having a wide practical application in wireless satellite telecommunications, is the total electron content (TEC representing the columnal electron number density. The F-region with high electron density provides the biggest contribution to TEC while the relatively weakly ionized plasma of the D-region (60 km { 90 km above Earth's surface is often considered as a negligible cause of satellite signal disturbances. However, sudden intensive ionization processes, like those induced by solar X-ray flares, can cause relative increases of electron density that are significantly larger in the D-region than in regions at higher altitudes. Therefore, one cannot exclude a priori the D-region from investigations of ionospheric influences on propagation of electromagnetic signals emitted by satellites. We discuss here this problem which has not been sufficiently treated in literature so far. The obtained results are based on data collected from the D-region monitoring by very low frequency radio waves and on vertical TEC calculations from the Global Navigation Satellite System (GNSS signal analyses, and they show noticeable variations in the D-region's electron content (TECD during activity of a solar X-ray °are (it rises by a factor of 136 in the considered case when TECD contribution to TEC can reach several percent and which cannot be neglected in practical applications like global positioning procedures by satellites. [Projekat Ministarstva nauke Republike Srbije, br. III-44002, 176001, 176002, 176004 and TR36020

  16. Features of annual and semiannual variations derived from the global ionospheric maps of total electron content

    Directory of Open Access Journals (Sweden)

    B. Zhao

    2008-01-01

    Full Text Available In the present work we use the NASA-JPL global ionospheric maps of total electron content (TEC, firstly to construct TEC maps (TEC vs. magnetic local time MLT, and magnetic latitude MLAT in the interval from 1999 to 2005. These TEC maps were, in turn, used to estimate the annual-to-mean amplitude ratio, A1, and the semiannual-to-mean amplitude ratio, A2, as well as the latitudinal symmetrical and asymmetrical parts, A' and A" of A1. Thus, we investigated in detail the TEC climatology from maps of these indices, with an emphasis on the quantitative presentation for local time and latitudinal changes in the seasonal, annual and semiannual anomalies of the ionospheric TEC. Then we took the TEC value at 14:00 LT to examine various anomalies at a global scale following the same procedure. Results reveal similar features appearing in NmF2, such as that the seasonal anomaly is more significant in the near-pole regions than in the far-pole regions and the reverse is true for the semiannual anomaly; the winter anomaly has least a chance to be observed at the South America and South Pacific areas. The most impressive feature is that the equinoctial asymmetry is most prominent at the East Asian and South Australian areas. Through the analysis of the TIMED GUVI columnar [O/N2] data, we have investigated to what extent the seasonal, annual and semiannual variations can be explained by their counterparts in [O/N2]. Results revealed that the [O/N2] variation is a major contributor to the daytime winter anomaly of TEC, and it also contributes to some of the semiannual and annual anomalies. The contribution to the anomalies unexplained by the [O/N2] data could possibly be due to the dynamics associated with thermospheric winds and electric fields.

  17. Mapping the total electron content over Malaysia using Spherical Cap Harmonic Analysis

    Science.gov (United States)

    Bahari, S.; Abdullah, M.; Bouya, Z.; Musa, T. A.

    2017-12-01

    The ionosphere over Malaysia is unique because of her location which is in close proximity to the geomagnetic equator and is in the equatorial regions. In this region, the magnetic field is horizontally oriented from south to north and field aligned direction is in the meridional plane (ExB) which becomes the source of equatorial ionospheric anomaly occurrence such as plasma bubble, fountain effects and others. Until today, there is no model that has been developed over Malaysia to study the ionosphere. Due to that, the main objective of this paper is to develop a new technique for mapping the total electron content (TEC) from GPS measurements. Data by myRTKnet network of GPS receiver over Malaysia were used in this study. A new methodology, based on modified spherical cap harmonic analysis (SCHA), was developed to estimate diurnal vertical TEC over the region using GPS observations. The SCHA model is based on longitudinal expansion in Fourier series and fractional Legendre co-latitudinal functions over a spherical cap-like region. The TEC map with spatial resolution of 0.15 ° x 0.15 ° in latitude and longitude with the time resolution of 30 seconds are derived. TEC maps from the SCHA model were compared with the global ionospheric map and other regional models. Result shows that during low solar activity, SCHA model had a better mapping with the accuracy of less than 1 TECU compared to other regional models.

  18. Finding multiscale connectivity in our geospace observational system: Network analysis of total electron content

    Science.gov (United States)

    McGranaghan, Ryan M.; Mannucci, Anthony J.; Verkhoglyadova, Olga; Malik, Nishant

    2017-07-01

    We present the first complex network theory-based analysis of high-latitude total electron content (TEC) data, including dependencies on interplanetary magnetic field (IMF) clock angle and hemisphere. We examine several network measures to quantify the spatiotemporal correlation patterns in the TEC data for winter and summer months in 2016. We find that significant structure exists in the correlation patterns, distinguishing the dayside and nightside ionosphere, and specific features in the high latitudes such as the polar cap and auroral oval, including the cusp and ionospheric foot points of magnetospheric boundary layers. These features vary with the IMF, exhibiting a strong dependence on the north-south direction and generally larger variations during the winter months in both hemispheres. Our exploratory results suggest that network analysis of TEC data can be used to study characteristic ionospheric spatial scales at high latitudes, thereby extending the utility of these data. We explore mesoscale and large scale (greater than tens of kilometers and greater than hundreds of kilometers, respectively) as a function of winter/summer season, hemisphere, and IMF direction and conclude that the relative importance of different ionospheric scales is not a constant relationship. Together with an identification of important areas of future work, our findings provide a foundation for the application of network analysis techniques to ionospheric TEC. Our results suggest that network analysis can reveal new physical connections in the ionospheric system.

  19. Spatial distribution of total electron content in the Arctic region of Russia from GPS data

    Science.gov (United States)

    Perevalova, Natalya; Romanova, Elena; Katashevtseva, Darya; Timofeeva, Olga

    2015-12-01

    Preliminary results of studying the spatial distribution of the total electron content (TEC) in the Arctic region of Russia are presented. The study is based on double frequency phase data obtained at four high-latitude GPS stations (LOVJ, Murmansk; NRIL, Norilsk; TIXI, Tiksi; BILB, Bilibino) on May 4-6, 2013 at 04:00-10:00 UT. On some receiver - GPS satellite rays northward of the stations, we have detected sharp TEC decreases or increases which argue for existence of a low electron density region (ionization trough) in the ionosphere. As found from the analysis of displacement of receiver' satellite rays, the ionization trough was located at latitudes of 72-84° N and longitudes of 0-200° E. The obtained results are consistent with numerical simulation data.

  20. Regional Arctic observations of TEC gradients and scintillations

    DEFF Research Database (Denmark)

    Durgonics, Tibor; Høeg, Per; von Benzon, Hans-Henrik

    2015-01-01

    near-real time observations of the stateand variations of the high-latitude ionosphere. This data can be employed to obtain relevant geophysical variablesand statistics. In our study GPS-derived total electron content (TEC) measurements have been complemented with amplitudescintillation indices (S4......), and phase scintillation indices (σϕ) The investigation of relations of these geophysical variables can lead to possible new ways to study the underlying processes and to build tools for monitoring and predicting Arctic TEC and scintillation large-scale patterns. A number of specific ionosphere events...... will be presented and the underlying geophysical process will be identified and described. Especially results where large-scale gradients in the regional TEC are compared with the growth of scintillations.The statistics of the scintillations will be investigated, with emphasis on how well the scintillations follow...

  1. Seismo-Ionospheric Coupling as Intensified EIA Observed by Satellite Electron Density and GPS-TEC Data

    Science.gov (United States)

    Ryu, K.; Jangsoo, C.; Kim, S. G.; Jeong, K. S.; Parrot, M.; Pulinets, S. A.; Oyama, K. I.

    2014-12-01

    Examples of intensified EIA features temporally and spatially related to large earthquakes observed by satellites and GPS-TEC are introduced. The precursory, concurrent, and ex-post enhancements of EIA represented by the equatorial electron density, which are thought to be related to the M8.7 Northern Sumatra earthquake of March 2005, the M8.0 Pisco earthquake of August 2007, and the M7.9 Wenchuan Earthquake of 12 May 2008, are shown with space weather condition. Based on the case studies, statistical analysis on the ionospheric electron density data measured by the Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions satellite (DEMETER) over a period of 2005-2010 was executed in order to investigate the correlation between seismic activity and equatorial plasma density variations. To simplify the analysis, three equatorial regions with frequent earthquakes were selected and then one-dimensional time series analysis between the daily seismic activity indices and the EIA intensity indices were performed for each region with excluding the possible effects from the geomagnetic and solar activity. The statistically significant values of the lagged cross-correlation function, particularly in the region with minimal effects of longitudinal asymmetry, indicate that some of the very large earthquakes with M > 7.0 in the low latitude region can accompany observable seismo-ionospheric coupling phenomena in the form of EIA enhancements, even though the seismic activity is not the most significant driver of the equatorial ionospheric evolution. The physical mechanisms of the seismo-ionospheric coupling to explain the observation and the possibility of earthquake prediction using the EIA intensity variation are discussed.

  2. Relations between Arctic large-scale TEC changes and scintillations over Greenland

    DEFF Research Database (Denmark)

    Durgonics, Tibor; Høeg, Per; von Benzon, Hans-Henrik

    wind, and the Earth’s magnetic field contribute to errors in satellite navigationpositioning and communication systems. In this study we will focus on the impact of space weatherin the Arctic region related to total electron content (TEC) and scintillation changes.Measurements from the GNSS network...... of stations in Greenland are analyzed and geophysicalvariables such as such as TEC, amplitude scintillation indices (S4), and phase scintillation indices (σϕ), are calculated together with 2D/3D electron density and scintillation maps. For the TEC weapplied data from the Greenland GNET network of stations...... obtained from the Greenland magnetic stations. Extremeionosphere events will be presented and the underlying geophysical process will be identified anddiscussed. Especially results where large-scale gradients in the regional TEC are compared with thegrowth of scintillations.We will identify crucial...

  3. Seismo-Ionospheric Precursor in the GIM TEC of the 24 August 2014 M6 Napa Earthquake

    Science.gov (United States)

    Wu, T. Y.; Liu, T. J. Y.; Liu, J. Y.

    2015-12-01

    This study examines seismo-ionospheric precursors (SIPs) in the global ionosphere map (GIM) of the total electron content (TEC) associated with the 24 August 2014 M6 South Napa earthquake and statistical evidence of SIPs of the GPS TEC in western USA during 2000-2014. The temporal SIP in the GIM TEC around the epicenter significantly decreasing (negative anomaly) on 22 August. To discriminate the global effect, such as solar flares, magnetic storms, etc., and the local effect, such as earthquakes, 5183 lattices on the GIM are employed to conduct a global search of the SIP distribution. Anomalies of both GIM TEC and associated gradients specifically and continuously appearing over the epicenter suggest that the SIP relate to the 2014 South Napa earthquake. A simulation is further carried out to produce the SIP in GIM TEC before the earthquake. Results indicate that the eastward electric field generated over the epicenter area during the earthquake preparation period to be essential.

  4. Comparison of simultaneous variations of the ionospheric total electron content and geomagnetic field associated with strong earthquakes

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    Sh. Naaman

    2001-01-01

    Full Text Available In this paper, perturbations of the ionospheric Total Electron Content (TEC are compared with geomagnetic oscillations. Comparison is made for a few selected periods, some during earthquakes in California and Japan and others at quiet periods in Israel and California. Anomalies in TEC were extracted using Global Positioning System (GPS observations collected by GIL (GPS in Israel and the California permanent GPS networks. Geomagnetic data were collected in some regions where geomagnetic observatories and the GPS network overlaps. Sensitivity of the GPS method and basic wave characteristics of the ionospheric TEC perturbations are discussed. We study temporal variations of ionospheric TEC structures with highest reasonable spatial resolution around 50 km. Our results show no detectable TEC disturbances caused by right-lateral strike-slip earthquakes with minor vertical displacement. However, geomagnetic observations obtained at two observatories located in the epicenter zone of a strong dip-slip earthquake (Kyuchu, M = 6.2, 26 March 1997 revealed geomagnetic disturbances occurred 6–7 h before the earthquake.

  5. Storm-time total electron content and its response to penetration electric fields over South America

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    P. M. de Siqueira

    2011-10-01

    Full Text Available In this work the response of the ionosphere due to the severe magnetic storm of 7–10 November 2004 is investigated by analyzing GPS Total Electron Content (TEC maps constructed for the South America sector. In order to verify the disturbed zonal electric fields in South America during the superstorm, ionospheric vertical drift data obtained from modeling results are used in the analysis. The vertical drifts were inferred from ΔH magnetometer data (Jicamarca-Piura following the methodology presented by Anderson et al. (2004. Also used were vertical drifts measured by the Jicamarca ISR. Data from a digisonde located at São Luís, Brazil (2.33° S, 44.2° W, dip latitude 0.25° are presented to complement the Jicamarca equatorial data. Penetration electric fields were observed by the comparison between the equatorial vertical drifts and the Interplanetary Electric Field (IEF. The TEC maps obtained from GPS data reflect the ionospheric response over the South America low-latitude and equatorial region. They reveal unexpected plasma distributions and TEC levels during the main phase of the superstorm on 7 November, which is coincident with the local post-sunset hours. At this time an increase in the pre-reversal enhancement was expected to develop the Equatorial Ionization Anomaly (EIA but we observed the absence of EIA. The results also reveal well known characteristics of the plasma distributions on 8, 9, and 10 November. The emphasized features are the expansion and intensification of EIA due to prompt penetration electric fields on 9 November and the inhibition of EIA during post-sunset hours on 7, 8, and 10 November. One important result is that the TEC maps provided a bi-dimensional view of the ionospheric changes offering a spatial description of the electrodynamics involved, which is an advantage over TEC measured by isolated GPS receivers.

  6. Southern European ionospheric TEC maps based on Kriging technique to monitor ionosphere behavior

    Science.gov (United States)

    Rodríguez-Bouza, Marta; Paparini, Claudia; Otero, Xurxo; Herraiz, Miguel; Radicella, Sandro M.; Abe, Oladipo E.; Rodríguez-Caderot, Gracia

    2017-10-01

    Global or regional Maps of the ionospheric Total Electron Content (TEC) are an efficient tool to monitor the delay introduced by the ionosphere in the satellite signals. Ionospheric disturbance periods are of particular interest because these conditions can strongly affect satellite navigation range measurements. This work presents post-processing regional vertical TEC maps over Southern Europe ([35°N-50°N] latitude) obtained by applying Kriging interpolation to GPS derived TEC over more than 100 Global Navigation Satellite System (GNSS) stations. These maps are used to study the behavior of the ionosphere during space weather events and their effects. To validate these maps, hereafter called Southern European Ionospheric Maps (SEIMs), their TEC values have been compared with those obtained from EGNOS Message Server (EMS) and with direct experimental TEC data from GNSS stations. Ionospheric space weather events related to geomagnetic storms of March 17th, 2013, February 19th, 2014 and March 17th, 2015 have been selected. To test the methodology, one period of quiet days has been also analyzed. TEC values obtained by SEIMs in the Ionospheric Grid Points (IGPs) defined by EGNOS are very close to those given by EMS and in the period of major geomagnetic storms the difference does not exceed 6 TEC units. These results confirm the good performance of the technique used for obtaining the SEIMs that can be a useful tool to study the ionosphere behavior during geomagnetic storms and their effects in the region of interest.

  7. A Year-Long Comparison of GPS TEC and Global Ionosphere-Thermosphere Models

    Science.gov (United States)

    Perlongo, N. J.; Ridley, A. J.; Cnossen, I.; Wu, C.

    2018-02-01

    The prevalence of GPS total electron content (TEC) observations has provided an opportunity for extensive global ionosphere-thermosphere model validation efforts. This study presents a year-long data-model comparison using the Global Ionosphere-Thermosphere Model (GITM) and the Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM). For the entire year of 2010, each model was run and compared to GPS TEC observations. The results were binned according to season, latitude, local time, and magnetic local time. GITM was found to overestimate the TEC everywhere, except on the midlatitude nightside, due to high O/N2 ratios. TIE-GCM produced much less TEC and had lower O/N2 ratios and neutral wind speeds. Seasonal and regional biases in the models are discussed along with ideas for model improvements and further validation efforts.

  8. Response of lightning energy and total electron content with sprites over Antarctic Peninsula

    Science.gov (United States)

    Suparta, W.; Yusop, N.

    2017-05-01

    This paper investigates the response of the lightning energy with the total electron content (TEC) derived from GPS over Antarctic Peninsula during St Patrick’s geomagnetic storm. During this event, sprite as one of the mesospheric transient luminous events (TLEs) associated with positive cloud-to-ground (+CG) lightning discharges can be generated. In this work, GPS and lightning data for the period from 14 to 20 March 2015 is analyzed. Geomagnetic activity and electric field data are also processed to relate the geomagnetic storm and lightning. Results show that during St Patrick’s geomagnetic storm, the lighting energy was produced up to ∼257 kJ. The ionospheric TEC was obtained 60 TECU, 38 TECU and 78 TECU between 18:00 and 21:00 UT for OHI3, PALV and ROTH stations, respectively. The peak of lightning energy was observed 14 hours after peaked of TEC. Sprite possibly generated through the electrical coupling process between the top cloud, middle and upper atmosphere with the DC electric field found to be ∼10 mVm-1 which leading to the sprite generation after the return strokes on 18 March 2015.

  9. GPS scintillations and total electron content climatology in the southern low, middle and high latitude regions

    Directory of Open Access Journals (Sweden)

    Luca Spogli

    2013-06-01

    Full Text Available In recent years, several groups have installed high-frequency sampling receivers in the southern middle and high latitude regions, to monitor ionospheric scintillations and the total electron content (TEC changes. Taking advantage of the archive of continuous and systematic observations of the ionosphere on L-band by means of signals from the Global Positioning System (GPS, we present the first attempt at ionospheric scintillation and TEC mapping from Latin America to Antarctica. The climatology of the area considered is derived through Ground-Based Scintillation Climatology, a method that can identify ionospheric sectors in which scintillations are more likely to occur. This study also introduces the novel ionospheric scintillation 'hot-spot' analysis. This analysis first identifies the crucial areas of the ionosphere in terms of enhanced probability of scintillation occurrence, and then it studies the seasonal variation of the main scintillation and TEC-related parameters. The results produced by this sophisticated analysis give significant indications of the spatial/ temporal recurrences of plasma irregularities, which contributes to the extending of current knowledge of the mechanisms that cause scintillations, and consequently to the development of efficient tools to forecast space-weather-related ionospheric events.

  10. Storm induced large scale TIDs observed in GPS derived TEC

    Directory of Open Access Journals (Sweden)

    C. Borries

    2009-04-01

    Full Text Available This work is a first statistical analysis of large scale traveling ionospheric disturbances (LSTID in Europe using total electron content (TEC data derived from GNSS measurements. The GNSS receiver network in Europe is dense enough to map the ionospheric perturbation TEC with high horizontal resolution. The derived perturbation TEC maps are analysed studying the effect of space weather events on the ionosphere over Europe. Equatorward propagating storm induced wave packets have been identified during several geomagnetic storms. Characteristic parameters such as velocity, wavelength and direction were estimated from the perturbation TEC maps. Showing a mean wavelength of 2000 km, a mean period of 59 min and a phase speed of 684 ms−1 in average, the perturbations are allocated to LSTID. The comparison to LSTID observed over Japan shows an equal wavelength but a considerably faster phase speed. This might be attributed to the differences in the distance to the auroral region or inclination/declination of the geomagnetic field lines. The observed correlation between the LSTID amplitudes and the Auroral Electrojet (AE indicates that most of the wave like perturbations are exited by Joule heating. Particle precipitation effects could not be separated.

  11. Storm induced large scale TIDs observed in GPS derived TEC

    Directory of Open Access Journals (Sweden)

    C. Borries

    2009-04-01

    Full Text Available This work is a first statistical analysis of large scale traveling ionospheric disturbances (LSTID in Europe using total electron content (TEC data derived from GNSS measurements. The GNSS receiver network in Europe is dense enough to map the ionospheric perturbation TEC with high horizontal resolution. The derived perturbation TEC maps are analysed studying the effect of space weather events on the ionosphere over Europe.

    Equatorward propagating storm induced wave packets have been identified during several geomagnetic storms. Characteristic parameters such as velocity, wavelength and direction were estimated from the perturbation TEC maps. Showing a mean wavelength of 2000 km, a mean period of 59 min and a phase speed of 684 ms−1 in average, the perturbations are allocated to LSTID. The comparison to LSTID observed over Japan shows an equal wavelength but a considerably faster phase speed. This might be attributed to the differences in the distance to the auroral region or inclination/declination of the geomagnetic field lines.

    The observed correlation between the LSTID amplitudes and the Auroral Electrojet (AE indicates that most of the wave like perturbations are exited by Joule heating. Particle precipitation effects could not be separated.

  12. Preseismic TEC Changes for Tohoku-Oki Earthquake: Comparisons Between Simulations and Observations

    Directory of Open Access Journals (Sweden)

    Cheng-Ling Kuo

    2015-01-01

    Full Text Available Heki (2011 reported that the Japanese Global Positioning System (GPS dense network detected a precursory positive total electron content anomaly (TEC, with ΔTEC ~3 TECU, ~40 minutes before the Tohoku-Oki earthquake (Mw 9.0. Similar preseismic TEC anomalies were also observed in the 2010 Chile earthquake (Mw 8.8, 2004 Sumatra-Andaman (Mw 9.2 and the 1994 Hokkaido-Toho-Oki (Mw 8.3. In this paper we apply our improved lithosphere-atmosphere-ionosphere (LAI coupling model to compute the TEC variations and compare the simulation results with the reported TEC observations. For the Tohoku-Oki earthquake simulations we assumed that the stressed associated current started ~40 minutes before the earthquake, linearly increased and reached its maximum magnitude at the time of the earthquake main shock. It is suggested that a dynamo current density of ~25 nA m-2 is required to produce the observed ΔTEC ~3 TECU.

  13. Empirical model of TEC response to geomagnetic and solar forcing over Balkan Peninsula

    Science.gov (United States)

    Mukhtarov, P.; Andonov, B.; Pancheva, D.

    2018-01-01

    An empirical total electron content (TEC) model response to external forcing over Balkan Peninsula (35°N-50°N; 15°E-30°E) is built by using the Center for Orbit Determination of Europe (CODE) TEC data for full 17 years, January 1999 - December 2015. The external forcing includes geomagnetic activity described by the Kp-index and solar activity described by the solar radio flux F10.7. The model describes the most probable spatial distribution and temporal variability of the externally forced TEC anomalies assuming that they depend mainly on latitude, Kp-index, F10.7 and LT. The anomalies are expressed by the relative deviation of the TEC from its 15-day mean, rTEC, as the mean value is calculated from the 15 preceding days. The approach for building this regional model is similar to that of the global TEC model reported by Mukhtarov et al. (2013a) however it includes two important improvements related to short-term variability of the solar activity and amended geomagnetic forcing by using a "modified" Kp index. The quality assessment of the new constructing model procedure in terms of modeling error calculated for the period of 1999-2015 indicates significant improvement in accordance with the global TEC model (Mukhtarov et al., 2013a). The short-term prediction capabilities of the model based on the error calculations for 2016 are improved as well. In order to demonstrate how the model is able to reproduce the rTEC response to external forcing three geomagnetic storms, accompanied also with short-term solar activity variations, which occur at different seasons and solar activity conditions are presented.

  14. A spatial analysis of the ionospheric TEC anomalies prior to M7.0+ earthquakes during 2003-2014

    Science.gov (United States)

    Zhu, Fuying; Lin, Jian; Su, Fanfan; Zhou, Yiyan

    2016-11-01

    In the present paper, by using the global navigation satellite system total electron content (GNSS TEC), we conducted a statistical study on the spatial distribution of the seismo-ionospheric precursors (SIPs) before the occurrence of 133 shallow earthquakes of magnitude M ⩾ 7.0 in the global area during 2003-2014. To exclude the effect of space weather and geomagnetic disturbance, we considered the variations in the geomagnetic Dst indices, Kp indices, and the F10.7 indices; the GNSS TEC over the regions of ±10° near the epicenters is then investigated, and the spatial distribution of ionospheric TEC anomalies 0-15 days before the earthquakes is reported for the first time. We also statistically analyzed and compared the counts of the TEC anomalies over the epicenters in the eastern, southern, western, and northern directions 0-15 days prior to the earthquakes. Results show that the maximum occurrence number of ionospheric TEC negative anomalies specially appears over the epicenters and the anomalous behaviors of the ionospheric TEC attenuate slightly with the distance to the epicenters. However, the ionospheric TEC positive anomalies in the western direction have the biggest chance of occurring. Finally, the spatial distribution characteristics of the observed SIPs are explained by the electric-field-coupling model.

  15. Ionosphere TEC disturbances before strong earthquakes: observations, physics, modeling (Invited)

    Science.gov (United States)

    Namgaladze, A. A.

    2013-12-01

    The phenomenon of the pre-earthquake ionospheric disturbances is discussed. A number of typical TEC (Total Electron Content) relative disturbances is presented for several recent strong earthquakes occurred in different ionospheric conditions. Stable typical TEC deviations from quiet background state are observed few days before the strong seismic events in the vicinity of the earthquake epicenter and treated as ionospheric earthquake precursors. They don't move away from the source in contrast to the disturbances related with geomagnetic activity. Sunlit ionosphere approach leads to reduction of the disturbances up to their full disappearance, and effects regenerate at night. The TEC disturbances often observed in the magnetically conjugated areas as well. At low latitudes they accompany with equatorial anomaly modifications. The hypothesis about the electromagnetic channel of the pre-earthquake ionospheric disturbances' creation is discussed. The lithosphere and ionosphere are coupled by the vertical external electric currents as a result of ionization of the near-Earth air layer and vertical transport of the charged particles through the atmosphere over the fault. The external electric current densities exceeding the regular fair-weather electric currents by several orders are required to produce stable long-living seismogenic electric fields such as observed by onboard measurements of the 'Intercosmos-Bulgaria 1300' satellite over the seismic active zones. The numerical calculation results using the Upper Atmosphere Model demonstrate the ability of the external electric currents with the densities of 10-8-10-9 A/m2 to produce such electric fields. The sumulations reproduce the basic features of typical pre-earthquake TEC relative disturbances. It is shown that the plasma ExB drift under the action of the seismogenic electric field leads to the changes of the F2 region electron number density and TEC. The upward drift velocity component enhances NmF2 and TEC and

  16. Linear time series modeling of GPS-derived TEC observations over the Indo-Thailand region

    Science.gov (United States)

    Suraj, Puram Sai; Kumar Dabbakuti, J. R. K.; Chowdhary, V. Rajesh; Tripathi, Nitin K.; Ratnam, D. Venkata

    2017-12-01

    This paper proposes a linear time series model to represent the climatology of the ionosphere and to investigate the characteristics of hourly averaged total electron content (TEC). The GPS-TEC observation data at the Bengaluru international global navigation satellite system (GNSS) service (IGS) station (geographic 13.02°N , 77.57°E ; geomagnetic latitude 4.4°N ) have been utilized for processing the TEC data during an extended period (2009-2016) in the 24{th} solar cycle. Solar flux F10.7p index, geomagnetic Ap index, and periodic oscillation factors have been considered to construct a linear TEC model. It is evident from the results that solar activity effect on TEC is high. It reaches the maximum value (˜ 40 TECU) during the high solar activity (HSA) year (2014) and minimum value (˜ 15 TECU) during the low solar activity (LSA) year (2009). The larger magnitudes of semiannual variations are observed during the HSA periods. The geomagnetic effect on TEC is relatively low, with the highest being ˜ 4 TECU (March 2015). The magnitude of periodic variations can be seen more significantly during HSA periods (2013-2015) and less during LSA periods (2009-2011). The correlation coefficient of 0.89 between the observations and model-based estimations has been found. The RMSE between the observed TEC and model TEC values is 4.0 TECU (linear model) and 4.21 TECU (IRI2016 Model). Further, the linear TEC model has been validated at different latitudes over the northern low-latitude region. The solar component (F10.7p index) value decreases with an increase in latitude. The magnitudes of the periodic component become less significant with the increase in latitude. The influence of geomagnetic component becomes less significant at Lucknow GNSS station (26.76°N, 80.88°E) when compared to other GNSS stations. The hourly averaged TEC values have been considered and ionospheric features are well recovered with linear TEC model.

  17. Anomalous variations in ionospheric TEC prior to the 2011 Japan Ms9. 0 earthquake

    Directory of Open Access Journals (Sweden)

    Zhu Fuying

    2011-08-01

    Full Text Available The ionospheric total-electron-content (TEC data provided by the International GNSS Service (IGS network and the VTEC data from the GPS reference stations of Crustal Movement Observational Network of China(CMONC were processed and statistically analyzed to search for earthquake-related TEC anomalies prior to the 2011 magnitude 9.0 earthquake in Japan. Preliminary results showed that anomalous variations occurred 6 – 11 days and 0 – 4 days prior to the earthquake. After considering solar activity, geomagnetic conditions, and proximity in space and time to the earthquake, we tentatively concluded that the anomalous increase on March 5 may be related to the earthquake.

  18. A comparison between TEC obtained by the TOPEX/Poseidon borne GPS receiver and TEC from the Gallagher model

    International Nuclear Information System (INIS)

    Ciraolo, L.

    2003-01-01

    JPL archived RINEX files relative to the GPS receiver of TOPEX at the site bodhi.jplnasa.gov/pub/topex/rinex for years 1992, 1993, 1994, 1995, 1997. The GPS receiver on board was intended as a tool for precise orbitography, but from such data it is possible to extract Differential Phase and Group Delays providing with a biased estimate of slant Total Electron Content (TEC) from TOPEX to GPS. This means a very useful information about TEC in an area above 1340 up to 20000 km, or high topside and plasmasphere. It was possible to get some estimate of the minimum magnitude of slants that can be observed in such region. A comparison with slants obtained by the Gallagher was carried out, with interesting results

  19. A comparison between TEC obtained by the TOPEX/Poseidon borne GPS receiver and TEC from the Gallagher model

    CERN Document Server

    Ciraolo, L

    2002-01-01

    JPL archived RINEX files relative to the GPS receiver of TOPEX at the site bodhi.jplnasa.gov/pub/topex/rinex for years 1992, 1993, 1994, 1995, 1997. The GPS receiver on board was intended as a tool for precise orbitography, but from such data it is possible to extract Differential Phase and Group Delays providing with a biased estimate of slant Total Electron Content (TEC) from TOPEX to GPS. This means a very useful information about TEC in an area above 1340 up to 20000 km, or high topside and plasmasphere. It was possible to get some estimate of the minimum magnitude of slants that can be observed in such region. A comparison with slants obtained by the Gallagher was carried out, with interesting results.

  20. Imperfect coupling between northern and southern ionospheres: asymmetry in TEC anomalies before earthquakes

    Science.gov (United States)

    Jhuang, Hau-Kun; Ho, Yi-Ying; Lee, Lou-Chuang

    2016-04-01

    The northern ionosphere is coupled to the conjugate southern ionosphere through the highly conducting geomagenetic field lines. The coupling is very strong or "perfect" if the geomagnetic field lines are equipotential (the parallel electric field E||=0) and hence the perpendicular electric field (E⊥) at the conjugate sites of both ionospheres are equal. The coupling is "imperfect" if some of the geomagnetic field lines are non-equipotential (E||≠0). The field-aligned electric field E|| can be associated with electron inertia, pressure gradient and collisions appearing in the form of double layer, kinetic Alfvén waves and finite field-aligned conductivity σ||. We use the Global Ionospheric Maps (GIM) data to examine the conjugate effect of total electron content (TEC) for six significant earthquakes. The anomalous (ΔTEC)source in the source ionosphere and (ΔTEC)conjugate in the conjugate ionosphere are obtained for 85 events before the six earthquakes. The ΔTEC ratio β = (ΔTEC)conjugate / (ΔTEC)source is calculated for each anomaly. For a "perfect" coupling, β=1. There are 85 anomalous events before the six significant earthquakes, with 62 events occurring in the daytime (07-18 LT) and 23 events in the nighttime (19-06 LT). The average value of daytime (07-18 LT) TEC variations in the source ionosphere is |ΔTEC|source =20.13 TECu, while the average value in the nighttime (19-06 LT) ionosphere is |ΔTEC|source=14.43 TECu. The value of ΔTEC ratio β ranges from 0.05 (very weak coupling) to 0.98 (nearly perfect coupling) with an average of 0.52. There are 14 strong coupling cases with β ≥0.8, which take place from 11 LT to 19 LT. The daytime (07-18 LT) β average value is 0.57 and the nighttime (19-06 LT) β average is 0.37. The south-north ionosphere coupling is stronger (weaker) in the daytime (nighttime).

  1. Behavior of the ionosphere total electronic content in Sao Jose dos Campos during magnetic storms in 1980

    International Nuclear Information System (INIS)

    Paula, E.R. de; Abdu, M.A.; Kantor, I.J.

    1983-07-01

    Faraday rotation data from 1980, obtained with a polarimeter at Sao Jose dos Campos (23 0 S, 46 0 W), were analyzed during periods occurring magnetic storms. In order to select these periods, the magnetic index Dst was used. It was observed that during magnetic storms preceeded by a few calm days, an increase in the Total Electron Content (TEC) is observed during the storm main phase, relative to the mean of the magnetic calm days (positive phase). Afterwards, during the storms recovery phase, a decrease was registered relative to the average (negative phase). This TEC behaviour, observed at low latitudes storms, is typical of the behaviour over medium latitudes. But, when several storms occur with few intervening days between them, the positive phase seems to prevail. This indicates an inibition of the source of the negative phase. This work discusses the possible origins of the positive and negative phases. (Author) [pt

  2. Does TEC react to a sudden impulse as a whole? The 2015 Saint Patrick's day storm event

    Science.gov (United States)

    Piersanti, M.; Cesaroni, C.; Spogli, L.; Alberti, T.

    2017-10-01

    We provide insights about how the Total Electron Content (TEC), derived by a network of Global Navigation Satellite System (GNSS) receivers over the European longitudinal sector, reacts to a Sudden Impulse (SI). In particular, we investigate how the different components of the TEC variability relates with the ionospheric currents, derived by ground magnetometers and the Piersanti and Villante (2016) model, during the 2015 Saint Patrick's Day storm. To identify the different TEC components, we apply the Ensemble Empirical Mode Decomposition (EEMD) analysis to vertical TEC (vTEC) time series to isolate its SI-related variations over co-located GNSS receiver-magnetometer couples. With such an approach, we were able to identify for the first time a peculiar vTEC mode (WHT∗, T ≃ 45 min) switching on during the SI and propagating southward with a velocity of ∼1.5 km/s. We also found a linear relationship between the estimated ionospheric current and the temporal fluctuations of WHT∗ for both the Preliminary Impulse (PI) and the Main Impulse (MI). The slope has been found to depend only on the electron charge, on the magnetic permeability and on the altitude of the ionospheric E-layer, as expected from first principles equations and as discussed in details.

  3. TEC ingestion into NeQuick 2 to model the East African equatorial ionosphere

    Science.gov (United States)

    Nigussie, M.; Radicella, S. M.; Damtie, B.; Nava, B.; Yizengaw, E.; Ciraolo, L.

    2012-10-01

    NeQuick 2 ionospheric empirical model depends on global ionospheric coefficients that are estimated from unevenly distributed ionosonde measurements. In regions, like Africa, where very few observational data were available until recently, the model estimated the ionospheric peak parameters by interpolation. When one wants to employ the model to specify the ionosphere where very few data have been used for model development, the performances of the model need careful validation. This study investigates the performances of NeQuick 2 in the East African region by assisting the model with measurements from a single Global Positioning System (GPS) receiver, which has been deployed recently. This can be done by first calculating an effective ionization level that drives NeQuick 2 to compute slant total electron content (sTEC) which fits, in the least square sense, with the measurements taken from a single GPS receiver. We then quantify the performances of NeQuick 2 in reproducing the measured TEC by running the model at four other locations, where GPS stations are available, using the same effective ionization level that we calculated from a single GPS station as a driver of the model. Finally, the performances of the model before and after data ingestion have been investigated by comparing the model results with the experimental sTEC and vertical TEC (vTEC) obtained from the four test stations. Three months data during low solar activity conditions have been used for this study. We have shown that the capability of NeQuick 2, in describing the East African region of the ionosphere, can be improved substantially by data ingestion. We found that the model after ingestion reproduces the experimental TEC better as far as about 620 km away from the reference station than that before adaptation. The statistical comparisons of the performances of the model in reproducing sTEC before and after ingestion are also discussed in this study.

  4. Performance of GPS slant total electron content and IRI-Plas-STEC for days with ionospheric disturbance

    Directory of Open Access Journals (Sweden)

    Feza Arikan

    2016-01-01

    Full Text Available Total Electron Content (TEC is an important observable parameter of the ionosphere which forms the main source of error for space based navigation and positioning systems. Since the deployment of Global Navigation Satellite Systems (GNSS, cost-effective estimation of TEC between the earth based receiver and Global Positioning System (GPS satellites became the major means of investigation of local and regional disturbance for earthquake precursor and augmentation system studies. International Reference Ionosphere (IRI extended to plasmasphere (IRI-Plas is the most developed ionospheric and plasmaspheric climatic model that provides hourly, monthly median of electron density distribution globally. Recently, IONOLAB group (www.ionolab.org has presented a new online space weather service that can compute slant TEC (STEC on a desired ray path for a given date and time using IRI-Plas model (IRI-Plas-STEC. In this study, the performance of the model based STEC is compared with GPS-STEC computed according to the estimation method developed by the IONOLAB group and includes the receiver bias as IONOLAB-BIAS (IONOLAB-STEC. Using Symmetric Kullback–Leibler Distance (SKLD, Cross Correlation (CC coefficient and the metric norm (L2N to compare IRI-Plas-STEC and IONOLAB-STEC for the month of October 2011 over the Turkish National Permanent GPS Network (TNPGN-Active, it has been observed that SKLD provides a good indicator of disturbance for both earthquakes and geomagnetic storms.

  5. Test of GPS for permanent ionospheric TEC monitoring at high latitudes

    Directory of Open Access Journals (Sweden)

    N. Zarraoa

    Full Text Available The Global Positioning System (GPS observables are affected by the ionosphere. The dispersive nature of this effect and the use of two frequencies in the GPS observations make possible to measure the ionospheric total electron content (TEC from dual frequency GPS data. In this work we test the concept of permanent monitoring of TEC using a network of GPS receivers at high latitudes. We have used GPS data from five permanent receivers in Scandinavia, from 1-30 January 1994, with geographic latitudes ranging from 57.4°N to 78.9°N. The results show the capability of the method to monitor the evolution of TEC as a function of time and geographical location. We have detected night-time enhancements almost every night for some of the stations, and we have also been able to produce maps of the instantaneous TEC as a function of both latitude and longitude around the GPS network. We also present some of the current limitations in the use of GPS for estimating TEC at high latitudes such as the difficulties in solving for cycle-slips, and the necessity of reliable values for the receiver and satellite differential instrumental biases.

  6. Ionospheric Anomalies Observed by GPS TEC Prior to the Qinghai-Tibet Region Earthquakes

    Directory of Open Access Journals (Sweden)

    Chunliang Xia

    2011-01-01

    Full Text Available The precursory processes detected from unambiguous and repeatable instrumental observations that precede an earthquake remain elusive despite the multiple types of pre-earthquake signals gained from observations of geo-electricity, geomagnetism, and electromagnetism. Recently, much attention has been paid to associate abnormal behaviors of TEC (total electron content in ionosphere, with seismic forcing. In this paper, we examined ionospheric TEC variations 1 - 2 weeks preceding 20 moderate to great earthquakes (M = 5 - 8 in the Tibetan Plateau and its neighboring regions between 1999 to 2008, with the help of a nationwide continuously-tracking GPS network. The temporal and spatial TEC variations over the specific seismogenic zones were calculated, and the causal linkage between the identified TEC anomalies and these earthquakes was examined. We find that most of the earthquakes showed significant abnormalities with similar characteristics. The anomalies, either upper anomalies (85%, 17/20 or lower anomalies (65%, 13/20 occurred in the ionosphere with dimensions of 30¢X in latitude and 30¢X in longitude above the epicenters. It is noted that the ionospheric anomalies were more dependent on focal depths of earthquakes than their magnitudes. Our results suggest that these anomalies of TEC may be possible seismo-ionospheric signatures for the earthquakes in Tibet and its margins.

  7. Electron content near the lunar surface using dual-frequency VLBI tracking data in a single lunar orbiter mission

    International Nuclear Information System (INIS)

    Wang, Zhen; Wang, Na; Ping, Jin-Song

    2015-01-01

    In VLBI observations of Vstar, a subsatellite of the Japanese lunar mission SELENE, there were opportunities for lunar grazing occultation when Vstar was very close to the limb of the Moon. This kind of chance made it possible to probe the thin plasma layer above the Moon's surface as a meaningful by-product of VLBI, by using the radio occultation method with coherent radio waves from the S/X bands. The dual-frequency measurements were carried out at Earth-based VLBI stations. In the line-of-sight direction between the satellite and the ground-based tracking station where VLBI measurements were made, the effects of the terrestrial ionosphere, interplanetary plasma and the thin lunar ionosphere mixed together in the combined observables of dual-frequency Doppler shift and phase shift. To separate the variation of the ionospheric total electron content (TEC) near the surface of the Moon from the mixed signal, the influences of the terrestrial ionosphere and interplanetary plasma have been removed by using an extrapolation method based on a short-term trend. The lunar TEC is estimated from the dual-frequency observation for Vstar from UT 22:18 to UT 22:20 on 2008 June 28 at several tracking stations. The TEC results obtained from VLBI sites are identical, however, they are not as remarkable as the result obtained at the Usuda deep space tracking station. (paper)

  8. Inverting Coseismic TEC Disturbances for Neutral Atmosphere Pressure Wave

    Science.gov (United States)

    Lee, R. F.; Mikesell, D.; Rolland, L.

    2017-12-01

    Research from the past 20 years has shown that we can detect coseismic disturbances in the total electron content (TEC) using global navigation space systems (GNSS). In the near field, TEC disturbances are created by the direct wave from rupture on the surface. This pressure wave travels through the neutral atmosphere to the ionosphere within about 10 minutes. This provides the opportunity to almost immediately characterize the source of the acoustic disturbance on the surface using methods from seismology. In populated areas, this could provide valuable information to first responders. To retrieve the surface motion amplitude information we must account for changes in the waveform caused by the geomagnetic field, motion of the satellites and the geometry of the satellites and receivers. One method is to use a transfer function to invert for the neutral atmosphere pressure wave. Gómez et al (2015) first employed an analytical model to invert for acoustic waves produced by Rayleigh waves propagating along the Earth's surface. Here, we examine the same model in the near field using the TEC disturbances from the direct wave produced by rupture at the surface. We compare results from the forward model against a numerical model that has been shown to be in good agreement with observations from the 2011 Van (Turkey) earthquake. We show the forward model predictions using both methods for the Van earthquake. We then analyze results for hypothetical events at different latitudes and discuss the reliability of the analytical model in each scenario. Gómez, D., R. Jr. Smalley, C. A. Langston, T. J. Wilson, M. Bevis, I. W. D. Dalziel, E. C. Kendrick, S. A. Konfal, M. J. Willis, D. A. Piñón, et al. (2015), Virtual array beamforming of GPS TEC observations of coseismic ionospheric disturbances near the Geomagnetic South Pole triggered by teleseismic megathrusts, J. Geophys. Res. Space Physics, 120, 9087-9101, doi:10.1002/2015JA021725.

  9. Digital processing of ionospheric electron content data

    Science.gov (United States)

    Bernhardt, P. A.

    1979-01-01

    Ionospheric electron content data contain periodicities that are produced by a diversity of sources including hydromagnetic waves, gravity waves, and lunar tides. Often these periodicities are masked by the strong daily variation in the data. Digital filtering can be used to isolate the weaker components. The filtered data can then be further processed to provide estimates of the source properties. In addition, homomorphic filtering may be used to identify nonlinear interactions in the ionosphere.

  10. Growth, Rewards, Collaboration in the TEC State.

    Science.gov (United States)

    Krueger, Christine

    This document represents a continuation of efforts partially reported in UNIVERSITIES AND TEACHER EDUCATION CENTERS IN FLORIDA. The present (1979) report presupposes the reader's familiarity with the contents of that previous document, and attempts to add to the picture of universities and TEC's by updating developments through the 1978-79 service…

  11. Total electron content variations over southern Europe before and during the M 6.3 Abruzzo earthquake of April 6, 2009

    Directory of Open Access Journals (Sweden)

    Spyrous D. Spatalas

    2012-04-01

    Full Text Available

    Total electron content (TEC data of 14 global positioning system (GPS stations of the EUREF network were provided by the IONOLAB. These were analyzed using wavelet analysis and discrete Fourier analysis to investigate the TEC variations over southern Europe in the month before the catastrophic Abruzzo earthquake of M 6.3 of April 6, 2009. The main conclusions of this analysis are: (a TEC oscillations in a broad range of frequencies occurred randomly over a broad area of several hundred kilometers from the earthquake; (b Morning and evening extensions of the day-time TEC values were seen for all of the EUREF stations of this program shortly before, during and shortly after the main earthquake period; (c High frequency oscillations (f $ 0.0003 Hz, period T $ 60 m appear to indicate the location of the earthquake, although with questionable accuracy, while the fractal characteristics of the frequency distribution indicates the locus of the earthquake with relatively greater accuracy. We conclude that the lithosphere-atmosphere-ionosphere coupling mechanism through acoustic or gravity waves might explain this phenomenology.

  12. Methodology and consistency of slant and vertical assessments for ionospheric electron content models

    Science.gov (United States)

    Hernández-Pajares, Manuel; Roma-Dollase, David; Krankowski, Andrzej; García-Rigo, Alberto; Orús-Pérez, Raül

    2017-12-01

    A summary of the main concepts on global ionospheric map(s) [hereinafter GIM(s)] of vertical total electron content (VTEC), with special emphasis on their assessment, is presented in this paper. It is based on the experience accumulated during almost two decades of collaborative work in the context of the international global navigation satellite systems (GNSS) service (IGS) ionosphere working group. A representative comparison of the two main assessments of ionospheric electron content models (VTEC-altimeter and difference of Slant TEC, based on independent global positioning system data GPS, dSTEC-GPS) is performed. It is based on 26 GPS receivers worldwide distributed and mostly placed on islands, from the last quarter of 2010 to the end of 2016. The consistency between dSTEC-GPS and VTEC-altimeter assessments for one of the most accurate IGS GIMs (the tomographic-kriging GIM `UQRG' computed by UPC) is shown. Typical error RMS values of 2 TECU for VTEC-altimeter and 0.5 TECU for dSTEC-GPS assessments are found. And, as expected by following a simple random model, there is a significant correlation between both RMS and specially relative errors, mainly evident when large enough number of observations per pass is considered. The authors expect that this manuscript will be useful for new analysis contributor centres and in general for the scientific and technical community interested in simple and truly external ways of validating electron content models of the ionosphere.

  13. INVESTIGATION OF THE RELATIONSHIP BETWEEN IONOSPHERIC TEC ANOMALY VARIATIONS AND FAULT TYPES BEFORE THE EARTHQUAKES

    Directory of Open Access Journals (Sweden)

    M. Ulukavak

    2017-11-01

    Full Text Available Earthquakes are natural phenomena that shake the earth and cause many damage. Since the time of arrival of the earthquakes cannot be determined directly, some signs before the earthquake should be examined and interpreted by examining the environmental changes. One of the methods used for this is monitoring the ionospheric total electron content (TEC changes in total electron content unit (TECU. GPS satellites have begun to be used as a means of monitoring ionospheric TEC anomalies before earthquakes since they began to be used as sensors around the world. In this study, three fault type (normal, thrust and strike-slip faulting of 28 earthquakes with a magnitude greater than 7 (Mw and the percentage changes of TEC anomalies before the earthquakes were investigated. The ionospheric TEC anomalies before the earthquake were calculated according to the 15-day running median statistical analysis method. Different solar and geomagnetic indices have been investigated to determine the active space weather conditions and quiet days before and after the earthquake. The TEC anomalies were determined during the quiet days before the earthquake by comparing the ionospheric anomalies that occurred before the earthquake after the determination of quiet days with the indices of the space weather conditions. The results show that there is a relationship between fault type and the earthquake precursor percentage changes and were determined as 47.6 % TECU for regions where normal faulting, 50.4 % TECU for regions where thrust faulting, and 44.2 % TECU for regions where strike-slip faulting occurred, respectively.

  14. Investigation of the Relationship Between Ionospheric TEC Anomaly Variations and Fault Types Before the Earthquakes

    Science.gov (United States)

    Ulukavak, M.; Yalçınkaya, M.

    2017-11-01

    Earthquakes are natural phenomena that shake the earth and cause many damage. Since the time of arrival of the earthquakes cannot be determined directly, some signs before the earthquake should be examined and interpreted by examining the environmental changes. One of the methods used for this is monitoring the ionospheric total electron content (TEC) changes in total electron content unit (TECU). GPS satellites have begun to be used as a means of monitoring ionospheric TEC anomalies before earthquakes since they began to be used as sensors around the world. In this study, three fault type (normal, thrust and strike-slip faulting) of 28 earthquakes with a magnitude greater than 7 (Mw) and the percentage changes of TEC anomalies before the earthquakes were investigated. The ionospheric TEC anomalies before the earthquake were calculated according to the 15-day running median statistical analysis method. Different solar and geomagnetic indices have been investigated to determine the active space weather conditions and quiet days before and after the earthquake. The TEC anomalies were determined during the quiet days before the earthquake by comparing the ionospheric anomalies that occurred before the earthquake after the determination of quiet days with the indices of the space weather conditions. The results show that there is a relationship between fault type and the earthquake precursor percentage changes and were determined as 47.6 % TECU for regions where normal faulting, 50.4 % TECU for regions where thrust faulting, and 44.2 % TECU for regions where strike-slip faulting occurred, respectively.

  15. Determination of the optimized single-layer ionospheric height for electron content measurements over China

    Science.gov (United States)

    Li, Min; Yuan, Yunbin; Zhang, Baocheng; Wang, Ningbo; Li, Zishen; Liu, Xifeng; Zhang, Xiao

    2018-02-01

    The ionosphere effective height (IEH) is a very important parameter in total electron content (TEC) measurements under the widely used single-layer model assumption. To overcome the requirement of a large amount of simultaneous vertical and slant ionospheric observations or dense "coinciding" pierce points data, a new approach comparing the converted vertical TEC (VTEC) value using mapping function based on a given IEH with the "ground truth" VTEC value provided by the combined International GNSS Service Global Ionospheric Maps is proposed for the determination of the optimal IEH. The optimal IEH in the Chinese region is determined using three different methods based on GNSS data. Based on the ionosonde data from three different locations in China, the altitude variation of the peak electron density (hmF2) is found to have clear diurnal, seasonal and latitudinal dependences, and the diurnal variation of hmF2 varies from approximately 210 to 520 km in Hainan. The determination of the optimal IEH employing the inverse method suggested by Birch et al. (Radio Sci 37, 2002. doi: 10.1029/2000rs002601) did not yield a consistent altitude in the Chinese region. Tests of the method minimizing the mapping function errors suggested by Nava et al. (Adv Space Res 39:1292-1297, 2007) indicate that the optimal IEH ranges from 400 to 600 km, and the height of 450 km is the most frequent IEH at both high and low solar activities. It is also confirmed that the IEH of 450-550 km is preferred for the Chinese region instead of the commonly adopted 350-450 km using the determination method of the optimal IEH proposed in this paper.

  16. Global Three-Dimensional Ionospheric Data Assimilation Model Using Ground-based GPS and Radio Occultation Total Electron Content

    Science.gov (United States)

    Jann-Yenq Liu, Tiger; Lin, Chi-Yen; Matsuo, Tomoko; Lin, Charles C. H.; Tsai, Ho-Fang; Chen, Chao-Yen

    2017-04-01

    An ionospheric data assimilation approach presented here is based on the Gauss-Markov Kalman filter with International Reference Ionosphere (IRI) as the background model and designed to assimilate the total electron content (TEC) observed from ground-based GPS receivers and space-based radio occultation (RO) of FORMOSAT-3/COSMIC (F3/C) or FORMOSAT-7/COSMIC-2 (F7/C2). The Kalman filter consists of the forecast step according to Gauss-Markov process and measurement update step. Observing System Simulation Experiments (OSSEs) show that the Gauss-Markov Kalman filter procedure can increase the accuracy of the data assimilation analysis over the procedure consisting of the measurement update step alone. Moreover, in comparing to F3/C, the dense F7/C2 RO observation can further increase the model accuracy significantly. Validating the data assimilation results with the vertical TEC in Global Ionosphere Maps and that derived from ground-based GPS measurements, as well as the ionospheric F2-peak height and electron density sounded by ionosondes is also carried out. Both the OSSE results and the observation validations confirm that the developed data assimilation model can be used to reconstruct the three-dimensional electron density in the ionosphere satisfactorily.

  17. Anomalous TEC variations associated with the powerful Tohoku earthquake of 11 March 2011

    Directory of Open Access Journals (Sweden)

    M. Akhoondzadeh

    2012-05-01

    Full Text Available On 11 March 2011 at 14:46:23 LT, the 4th largest earthquake ever recorded with a magnitude of 9.0 occurred near the northeast coast of Honshu in Japan (38.322° N, 142.369° E, Focal depth 29.0 km. In order to acknowledge the capabilities of Total Electron Content (TEC ionospheric precursor, in this study four methods including mean, median, wavelet transform, and Kalman filter have been applied to detect anomalous TEC variations concerning the Tohoku earthquake. The duration of the TEC time series dataset is 49 days at a time resolution of 2 h. All four methods detected a considerable number of anomalous occurrences during 1 to 10 days prior to the earthquake in a period of high geomagnetic activities. In this study, geomagnetic indices (i.e. Dst, Kp, Ap and F10.7 were used to distinguish pre-earthquake anomalies from the other anomalies related to the geomagnetic and solar activities. A good agreement in results was found between the different applied anomaly detection methods on TEC data.

  18. Anomalous variation in GPS based TEC measurements prior to the 30 September 2009 Sumatra Earthquake

    Science.gov (United States)

    Karia, Sheetal; Pathak, Kamlesh

    This paper investigates the features of pre-earthquake ionospheric anomalies in the total elec-tron content (TEC) data obtained on the basis of regular GPS observations from the GPS receiver at SVNIT Surat (21.16 N, 72.78 E Geog) located at the northern crest of equatorial anomaly region. The data has been analysed for 5 different earthquakes that occurred during 2009 in India and its neighbouring regions. Our observation shows that for the cases of the earthquake, in which the preparation area lies between the crests of the equatorial anomaly close to the geomagnetic equator the enhancement in TEC was followed by a depletion in TEC on the day of earthquake, which may be connected to the equatorial anomaly shape distortions. For the analysis of the ionospheric effects of one of such case-the 30 September 2009 Sumatra earthquake, Global Ionospheric Maps of TEC were used. The possible influence of the earth-quake preparation processes on the main low-latitude ionosphere peculiarity—the equatorial anomaly—is discussed.

  19. Global distribution of GPS losses of phase lock and total electron content slips during the 2005 May 15 and the 2003 November 20 magnetic storms

    Science.gov (United States)

    Yasyukevich, Yuriy; Astafeva, Elvira; Givetev, Ilya; Maksikov, Aleksey

    2015-12-01

    Using data of worldwide network of GPS receivers we investigated losses of GPS phase lock (LoL) during two strong magnetic storms. At fundamental L1 frequency, LoL density is found to increase up to 0.25 % and at L2 frequency the increase is up to 3 %. This is several times as much compared with the background level. During the 2003 November 20 magnetic storm, the number of total electron content (TEC) slips exceeded the background level ~50 times. During superstorms, the most number of GPS LoL is observed at low and high latitudes. At the same time, the area of numerous TEC slips correspond to auroral oval boundaries.

  20. Juno Radio Science Observations and Gravity Science Calibrations of Plasma Electron Content in Io Plasma Torus

    Science.gov (United States)

    Yang, Y. M.; Buccino, D.; Folkner, W. M.; Oudrhiri, K.; Phipps, P. H.; Parisi, M.; Kahan, D. S.

    2017-12-01

    Interplanetary and Earth ionosphere plasma electrons can have significant impacts on radio frequency signal propagation such as telecommunication between spacecraft and the Deep Space Network (DSN). On 27 August 2016, the first closest approach of The Juno spacecraft (Perijove 1) provided an opportunity to observe plasma electrons inside of the Io plasma torus using radio science measurements from Juno. Here, we report on the derivations of plasma electron content in the Io plasma torus by using two-way coherent radio science measurements made from Juno's Gravity Science Instrument and the Deep Space Network. During Perijove 1, Juno spacecraft passed through the inner region (perijove altitude of 1.06 Jovian Radii) between Jupiter and the Io plasma torus. Significant plasma electron variations of up to 30 TEC units were observed while the radio link between Juno and the DSN traveled through the Io plasma torus. In this research, we compare observations made by open-loop and closed-loop processes using different frequency radio signals, corresponding Io plasma torus model simulations, and other Earth ionosphere observations. The results of three-dimensional Io plasma model simulations are consistent with observations with some discrepancies. Results are shown to improve our understanding of the Io plasma torus effect on Juno gravity science measurements and its calibrations to reduce the corresponding (non-gravity field induced) radio frequency shift.

  1. A Regional GPS Receiver Network For Monitoring Mid-latitude Total Electron Content During Storms

    Science.gov (United States)

    Vernon, A.; Cander, Lj. R.

    A regional GPS receiver network has been used for monitoring mid-latitude total elec- tron content (TEC) during ionospheric storms at the current solar maximum. Differ- ent individual storms were examined to study how the temporal patterns of changes develop and how they are related to solar and geomagnetic activity for parameter de- scriptive of plasmaspheric-ionospheric ionisation. Use is then made of computer con- touring techniques to produce snapshot maps of TEC for different study cases. Com- parisons with the local ionosonde data at different phases of the storms enable the storm developments to be studied in detail.

  2. Long time series analysis of ionospheric TEC disturbance over seismically region in southwest China during low solar activity

    Science.gov (United States)

    Yan, Xiangxiang; Yu, Tao; Shan, Xinjian; Liu, Zhan; Wang, Zhenjie

    2016-04-01

    Recently, there are growing interests in studying the seismo-ionospheric disturbance prior to earthquakes, mainly including the anomalies in the electric field, magnetic field and plasma parameters. However, there are still some controversies over this topic, mainly because of strong day-to-day variability of the ionosphere itself. It is hard to determine whether the different forms of ionospheric disturbances are associated with earthquakes or not. Using data of Crustal Movement Observation Network of China (CMONC) and IGS (International GNSS Service), we attempt to give a statistical investigation about the total electron content (TEC) perturbation before 30 Mw6.0+ earthquakes during January 2000 to December 2010 in China. To determine the abnormal TEC signals, a quartile-based process is performed. At each time point we calculated the median M using the TEC values at the same local time for the preceding 15 days. In addition, we calculated the maps of differential TEC from global ionosphere maps (GIM) in the above period. It is shown that TEC anomalies were detected before 20 earthquakes, nearly 67%. The anomalies represent positive before most events and occurred mostly within 2-6 days before the shocks, significantly during the afternoon period, 1200-2000LT. Part of perturbations appeared more than one time. Moreover, the affected area of TEC is not coincide with the vertical projection of the epicenter but shifts equatorward and is controlled by equatorial ionization anomaly (EIA) crest. On the other hand, we analyzed variations of TEC over southwest China during a period of low solar and geomagnetic activity in April-October 2008, based on the data of CMONC. During that time, six large earthquakes with magnitude M≧6.0 occurred around the southwest region of China. The method to detect abnormal TEC signals is same with above statistical study. Known that the decisive role in the ionosphere state is performed by space weather effects, we compared the TEC

  3. Validation of measured poleward TEC gradient using multi-station GPS with Artificial Neural Network based TEC model in low latitude region for developing predictive capability of ionospheric scintillation

    Science.gov (United States)

    Sur, D.; Paul, A.

    2017-12-01

    The equatorial ionosphere shows sharp diurnal and latitudinal Total Electron Content (TEC) variations over a major part of the day. Equatorial ionosphere also exhibits intense post-sunset ionospheric irregularities. Accurate prediction of TEC in these low latitudes is not possible from standard ionospheric models. An Artificial Neural Network (ANN) based Vertical TEC (VTEC) model has been designed using TEC data in low latitude Indian longitude sector for accurate prediction of VTEC. GPS TEC data from the stations Calcutta (22.58°N, 88.38°E geographic, magnetic dip 32°), Baharampore (24.09°N, 88.25°E geographic, magnetic dip 35°) and Siliguri (26.72°N, 88.39°E geographic; magnetic dip 40°) are used as training dataset for the duration of January 2007-September 2011. Poleward VTEC gradients from northern EIA crest to region beyond EIA crest have been calculated from measured VTEC and compared with that obtained from ANN based VTEC model. TEC data from Calcutta and Siliguri are used to compute VTEC gradients during April 2013 and August-September 2013. It has been observed that poleward VTEC gradient computed from ANN based TEC model has shown good correlation with measured values during vernal and autumnal equinoxes of high solar activity periods of 2013. Possible correlation between measured poleward TEC gradients and post-sunset scintillations (S4 ≥ 0.4) from northern crest of EIA has been observed in this paper. From the observation, a suitable threshold poleward VTEC gradient has been proposed for possible occurrence of post-sunset scintillations at northern crest of EIA along 88°E longitude. Poleward VTEC gradients obtained from ANN based VTEC model are used to forecast possible ionospheric scintillation after post-sunset period using the threshold value. It has been observed that these predicted VTEC gradients obtained from ANN based VTEC model can forecast post-sunset L-band scintillation with an accuracy of 67% to 82% in this dynamic low latitude

  4. A new method for estimation of TEC from GNSS receivers during multiple cycle slips and data loss due to ionospheric irregularities

    Science.gov (United States)

    Dashora, Nirvikar

    2012-07-01

    Estimation of total electron content (TEC) is a must to utilize the GNSS signal for ionospheric research. The estimation of absolute ionospheric TEC from raw GNSS data itself is a lengthy and complex task and requires knowledge of sophisticated computer programming skills, satellite orbital geometry and many other aspects like GNSS signal structure, satellite and receiver specific information etc. Not many software are available that automatize the complex task of cycle slip detection and correction. The estimation of satellite and receiver biases is one more step left before getting true TEC. In equatorial and low latitudes, where the nighttime ionospheric irregularities are oft-occurring phenomena, estimation of TEC becomes a challenge. This is because, during TEC depletions and scintillations, the loss of lock in the receiver results either in data loss or sharp gradients in the recorded delays; more often for phase than code. Raw data in form of accumulated phase in radians and total code-range in meters show random occurrences of multiple cycle slips and data loss of several minutes in the data file. Thus, such phase and code data has to be corrected first before processing it to obtain TEC. Almost all available software/algorithms suggest flagging such data for no further use. Hence, TEC cannot be estimated during multiple cycle slip events within few minutes from raw GPS data. But, for ionospheric research the time of occurrence, evolution and drift of depletions are very useful. This paper details a complete new software for pre-processing the raw RINEX (receiver independent exchange format) data and retrieval of TEC using code and carrier-phase measurements from an stand alone dual frequency GPS receiver. We use modified and new sets of algorithms a GNSS receiver. It is significant to note that we are able to retrieves almost all the the corrupted TEC data points due to random multiple cycle slip events which are oft-occurring phenomena during ESF in

  5. Ionospheric GPS TEC Anomalies and M > = 5.9 Earthquakes in Indonesia during 1993 - 2002

    Directory of Open Access Journals (Sweden)

    Sarmoko Saroso

    2008-01-01

    Full Text Available Indonesia is one of the most seismically active regions in the world, containing numerous active volcanoes and subject to frequent earthquakes with epicenters distributed along the same regions as volcanoes. In this paper, a case study is carried out to investigate pre-earthquake ionospheric anomalies in total electron content (TEC during the Sulawesi earthquakes of 1993 - 2002, and the Sumatra-Andaman earthquake of 26 December 2004, the largest earthquake in the world since 1964. It is found that the ionospheric TECs remarkably decrease within 2 - 7 days before the earthquakes, and for the very powerful Sumatra-Andaman earthquake, the anomalies extend up to about 1600 km from the epicenter.

  6. Ionospheric GPS TEC Anomalies and M >= 5.9 Earthquakes in Indonesia during 1993 - 2002

    Directory of Open Access Journals (Sweden)

    Sarmoko Saroso

    2008-01-01

    Full Text Available Indonesia is one of the most seismically active regions in the world, containing numerous active volcanoes and subject to frequent earthquakes with epicenters distributed along the same regions as volcanoes. In this paper, a case study is carried out to investigate pre-earthquake ionospheric anomalies in total electron content (TEC during the Sulawesi earthquakes of 1993 - 2002, and the Sumatra-Andaman earthquake of 26 December 2004, the largest earthquake in the world since 1964. It is found that the ionospheric TECs remarkably decrease within 2 - 7 days before the earthquakes, and for the very powerful Sumatra-Andaman earthquake, the anomalies extend up to about 1600 km from the epicenter.

  7. Support vector machines for TEC seismo-ionospheric anomalies detection

    Directory of Open Access Journals (Sweden)

    M. Akhoondzadeh

    2013-02-01

    Full Text Available Using time series prediction methods, it is possible to pursue the behaviors of earthquake precursors in the future and to announce early warnings when the differences between the predicted value and the observed value exceed the predefined threshold value. Support Vector Machines (SVMs are widely used due to their many advantages for classification and regression tasks. This study is concerned with investigating the Total Electron Content (TEC time series by using a SVM to detect seismo-ionospheric anomalous variations induced by the three powerful earthquakes of Tohoku (11 March 2011, Haiti (12 January 2010 and Samoa (29 September 2009. The duration of TEC time series dataset is 49, 46 and 71 days, for Tohoku, Haiti and Samoa earthquakes, respectively, with each at time resolution of 2 h. In the case of Tohoku earthquake, the results show that the difference between the predicted value obtained from the SVM method and the observed value reaches the maximum value (i.e., 129.31 TECU at earthquake time in a period of high geomagnetic activities. The SVM method detected a considerable number of anomalous occurrences 1 and 2 days prior to the Haiti earthquake and also 1 and 5 days before the Samoa earthquake in a period of low geomagnetic activities. In order to show that the method is acting sensibly with regard to the results extracted during nonevent and event TEC data, i.e., to perform some null-hypothesis tests in which the methods would also be calibrated, the same period of data from the previous year of the Samoa earthquake date has been taken into the account. Further to this, in this study, the detected TEC anomalies using the SVM method were compared to the previous results (Akhoondzadeh and Saradjian, 2011; Akhoondzadeh, 2012 obtained from the mean, median, wavelet and Kalman filter methods. The SVM detected anomalies are similar to those detected using the previous methods. It can be concluded that SVM can be a suitable learning method

  8. Support vector machines for TEC seismo-ionospheric anomalies detection

    Science.gov (United States)

    Akhoondzadeh, M.

    2013-02-01

    Using time series prediction methods, it is possible to pursue the behaviors of earthquake precursors in the future and to announce early warnings when the differences between the predicted value and the observed value exceed the predefined threshold value. Support Vector Machines (SVMs) are widely used due to their many advantages for classification and regression tasks. This study is concerned with investigating the Total Electron Content (TEC) time series by using a SVM to detect seismo-ionospheric anomalous variations induced by the three powerful earthquakes of Tohoku (11 March 2011), Haiti (12 January 2010) and Samoa (29 September 2009). The duration of TEC time series dataset is 49, 46 and 71 days, for Tohoku, Haiti and Samoa earthquakes, respectively, with each at time resolution of 2 h. In the case of Tohoku earthquake, the results show that the difference between the predicted value obtained from the SVM method and the observed value reaches the maximum value (i.e., 129.31 TECU) at earthquake time in a period of high geomagnetic activities. The SVM method detected a considerable number of anomalous occurrences 1 and 2 days prior to the Haiti earthquake and also 1 and 5 days before the Samoa earthquake in a period of low geomagnetic activities. In order to show that the method is acting sensibly with regard to the results extracted during nonevent and event TEC data, i.e., to perform some null-hypothesis tests in which the methods would also be calibrated, the same period of data from the previous year of the Samoa earthquake date has been taken into the account. Further to this, in this study, the detected TEC anomalies using the SVM method were compared to the previous results (Akhoondzadeh and Saradjian, 2011; Akhoondzadeh, 2012) obtained from the mean, median, wavelet and Kalman filter methods. The SVM detected anomalies are similar to those detected using the previous methods. It can be concluded that SVM can be a suitable learning method to detect

  9. A recurrent neural network approach to quantitatively studying solar wind effects on TEC derived from GPS; preliminary results

    Directory of Open Access Journals (Sweden)

    J. B. Habarulema

    2009-05-01

    Full Text Available This paper attempts to describe the search for the parameter(s to represent solar wind effects in Global Positioning System total electron content (GPS TEC modelling using the technique of neural networks (NNs. A study is carried out by including solar wind velocity (Vsw, proton number density (Np and the Bz component of the interplanetary magnetic field (IMF Bz obtained from the Advanced Composition Explorer (ACE satellite as separate inputs to the NN each along with day number of the year (DN, hour (HR, a 4-month running mean of the daily sunspot number (R4 and the running mean of the previous eight 3-hourly magnetic A index values (A8. Hourly GPS TEC values derived from a dual frequency receiver located at Sutherland (32.38° S, 20.81° E, South Africa for 8 years (2000–2007 have been used to train the Elman neural network (ENN and the result has been used to predict TEC variations for a GPS station located at Cape Town (33.95° S, 18.47° E. Quantitative results indicate that each of the parameters considered may have some degree of influence on GPS TEC at certain periods although a decrease in prediction accuracy is also observed for some parameters for different days and seasons. It is also evident that there is still a difficulty in predicting TEC values during disturbed conditions. The improvements and degradation in prediction accuracies are both close to the benchmark values which lends weight to the belief that diurnal, seasonal, solar and magnetic variabilities may be the major determinants of TEC variability.

  10. A recurrent neural network approach to quantitatively studying solar wind effects on TEC derived from GPS; preliminary results

    Directory of Open Access Journals (Sweden)

    J. B. Habarulema

    2009-05-01

    Full Text Available This paper attempts to describe the search for the parameter(s to represent solar wind effects in Global Positioning System total electron content (GPS TEC modelling using the technique of neural networks (NNs. A study is carried out by including solar wind velocity (Vsw, proton number density (Np and the Bz component of the interplanetary magnetic field (IMF Bz obtained from the Advanced Composition Explorer (ACE satellite as separate inputs to the NN each along with day number of the year (DN, hour (HR, a 4-month running mean of the daily sunspot number (R4 and the running mean of the previous eight 3-hourly magnetic A index values (A8. Hourly GPS TEC values derived from a dual frequency receiver located at Sutherland (32.38° S, 20.81° E, South Africa for 8 years (2000–2007 have been used to train the Elman neural network (ENN and the result has been used to predict TEC variations for a GPS station located at Cape Town (33.95° S, 18.47° E. Quantitative results indicate that each of the parameters considered may have some degree of influence on GPS TEC at certain periods although a decrease in prediction accuracy is also observed for some parameters for different days and seasons. It is also evident that there is still a difficulty in predicting TEC values during disturbed conditions. The improvements and degradation in prediction accuracies are both close to the benchmark values which lends weight to the belief that diurnal, seasonal, solar and magnetic variabilities may be the major determinants of TEC variability.

  11. Investigating the Characteristics of Wavelike Oscillations by Decomposing Fluctuating TEC obtained from SCINDA GPS Receiver in Ethiopian

    Science.gov (United States)

    Nigussie, M.; Damtie, B.; Yizengaw, E.; Tesema, F.; Yirdaw, A. T.

    2016-12-01

    Recently some works have been done to investigate the characteristics of wavelike oscillation from the ionospheric total electron content (TEC) fluctuations without considering components of fluctuation that can be embedded together. Decomposing wavelike oscillations from TEC fluctuations and investigating their characteristics is very important since the fluctuation is the net effect of different waves. In this paper we have investigated the characteristics of components of wavelike oscillations from pre-sunset and post sunset TEC observations corresponding to S4 index greater than 0.15 obtained, during April 2012, from SCINDA GPS receiver (11 oN, 37.6 oE) deployed in Ethiopia. First the Empirical Model Decomposition (EMD) has been applied to decompose the TEC fluctuation into different mode of oscillations which are usually called Intrinsic Mode Function (IMF). Thereafter Hilbert-Huang Transform (HHT) and wavelet analysis have been applied on each component of wave-like TEC oscillation to investigate the characteristics of wave-like oscillations. The results from these two methods have shown excellent agreement. In addition, by applying the global wavelet spectrum analysis we have shown that the median period of oscillations vary from about 8-120 minutes. Moreover, of the components of wavelike structure we have found two components of TEC fluctuation with occurrence frequency of 92% and 91% and their oscillation periods are found to be about 17 minutes and about 47 minutes, respectively, which can be interpreted as small and medium scale gravity waves that are likely triggered by the motion of solar terminator.

  12. Global features of ionospheric slab thickness derived from JPL TEC and COSMIC observations

    Science.gov (United States)

    Huang, He; Liu, Libo

    2016-04-01

    The ionospheric equivalent slab thickness (EST) is the ratio of total electron content (TEC) to F2-layer peak electron density (NmF2), describing the thickness of the ionospheric profile. In this study, we retrieve EST from Jet Propulsion Laboratory (JPL) TEC data and NmF2 retrieved from Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) ionospheric radio occultation data. The diurnal, seasonal and solar activity variations of global EST are analyzed as the excellent spatial coverage of JPL TEC and COSMIC data. During solstices, daytime EST in the summer hemisphere is larger than that in the winter hemisphere, except in some high-latitude regions; and the reverse is true for the nighttime EST. The peaks of EST often appear at 0400 local time. The pre-sunrise enhancement in EST appears in all seasons, while the post-sunset enhancement in EST is not readily observed in equinox. The dependence of EST on solar activity is very complicated. Furthermore, an interesting phenomenon is found that EST is enhanced from 0° to 120° E in longitude and 30° to 75° S in latitude during nighttime, just to the east of Weddell Sea Anomaly, during equinox and southern hemisphere summer.

  13. Short-term estimation of GNSS TEC using a neural network model in Brazil

    Science.gov (United States)

    Ferreira, Arthur Amaral; Borges, Renato Alves; Paparini, Claudia; Ciraolo, Luigi; Radicella, Sandro M.

    2017-10-01

    This work presents a novel Neural Network (NN) model to estimate Total Electron Content (TEC) from Global Navigation Satellite Systems (GNSS) measurements in three distinct sectors in Brazil. The purpose of this work is to start the investigations on the development of a regional model that can be used to determine the vertical TEC over Brazil, aiming future applications on a near real-time frame estimations and short-term forecasting. The NN is used to estimate the GNSS TEC values at void locations, where no dual-frequency GNSS receiver that may be used as a source of data to GNSS TEC estimation is available. This approach is particularly useful for GNSS single-frequency users that rely on corrections of ionospheric range errors by TEC models. GNSS data from the first GLONASS network for research and development (GLONASS R&D network) installed in Latin America, and from the Brazilian Network for Continuous Monitoring of the GNSS (RMBC) were used on TEC calibration. The input parameters of the NN model are based on features known to influence TEC values, such as geographic location of the GNSS receiver, magnetic activity, seasonal and diurnal variations, and solar activity. Data from two ten-days periods (from DoY 154 to 163 and from 282 to 291) are used to train the network. Three distinct analyses have been carried out in order to assess time-varying and spatial performance of the model. At the spatial performance analysis, for each region, a set of stations is chosen to provide training data to the NN, and after the training procedure, the NN is used to estimate vTEC behavior for the test station which data were not presented to the NN in training process. An analysis is done by comparing, for each testing station, the estimated NN vTEC delivered by the NN and reference calibrated vTEC. Also, as a second analysis, the network ability to forecast one day after the time interval (DoY 292) based on information of the second period of investigation is also assessed

  14. Development of a methodology for deriving Plasmaspheric Total Electron Content from In-Situ electron density measurements in highly eccentric equatorial orbits

    Science.gov (United States)

    Sadhique, Aliyuthuman; Buckley, Andrew; Gough, Paul; Sussex Space Science Centre Team

    2017-10-01

    The contribution of the Upper Plasmasphere (defined as the altitudes above semi-synchronous orbit height to the Plasmapause height) to the TEC has been and continues to be un-quantified. The PEACE instrument in the Chinese - ESA Double Star TC1 satellite, the mission's orbit's high eccentricity, low perigee, high apogee and the resulting smaller incident angle while in the above altitude range provide the ideal geometric opportunity to build a methodology and to utilize its empirical in-situ electron density measurements to determine the Upper Plasmaspheric TEC component. Furthermore, the variation of the Inclination Angle of TC1 makes it a suitable equatorial mission confined to the Near-Equatorial region, ie 200 - 250 on either sides of the magnetic equator. As the most pronounced absolute TEC values and variations are within this region, it offers an excellent opportunity to build a Upper Plasmaspheric TEC database. This research generates such, first-ever database along its orbital path, using a methodology of approximation equating arcs of the orbits to straight-line TEC Bars, utilizing complex mathematics, also enabling the determination of the whole Plasmaspheric TEC from any eccentric orbital probe. Presented the paper in 15th International Workshop on Technical and Scientific Aspects of MST radar (MST15/iMST2)'' and ``18th EISCAT Symposium (EISCAT18)'' in Tokyo, Japan and The Royal Astronomical Society National Astronomy Meeting 2017.

  15. Statistical seismo-ionospheric precursors of M7.0+ earthquakes in Circum-Pacific seismic belt by GPS TEC measurements

    Science.gov (United States)

    Li, Wang; Yue, Jianping; Guo, Jinyun; Yang, Yang; Zou, Bin; Shen, Yi; Zhang, Kefei

    2018-03-01

    The Circum-Pacific seismic belt is the region heavily affected by earthquakes in the world. The relationship between earthquake (e.g., the geographic location, occurrence time, magnitude, and focal depth) and ionospheric anomalies in the belt was investigated using 100 M7.0+ earthquakes during 2006-2015. The ground-based GPS measurements and global ionosphere map (GIM) data were used for the analyses of the ionospheric variations preceding the earthquakes. The results indicated that the occurrence rate of total electron content (TEC) anomalies was proportional to the magnitude and inversely proportional to the focal depth to a certain degree, and the occurrence frequency of anomalies had a rising trend with the days getting close to the main shock. The occurrence rate of TEC anomalies in the Southern hemisphere was larger than that in the Northern hemisphere. Besides, the spatial characteristics of TEC anomalies showed that the anomalies in low-middle latitudes did not coincide with the epicenter, sometimes the anomalies were also observed in the corresponding conjugated region. However, the TEC anomalies in the high latitude usually appeared around the epicenter and within the seismogenic zone while no TEC anomalies appeared in the conjugated area. These results may have potential applications to the earthquake prediction in the Circum-Pacific seismic belt.

  16. GPS TEC, scintillation and cycle slips observed at high latitudes during solar minimum

    Directory of Open Access Journals (Sweden)

    P. Prikryl

    2010-06-01

    Full Text Available High-latitude irregularities can impair the operation of GPS-based devices by causing fluctuations of GPS signal amplitude and phase, also known as scintillation. Severe scintillation events lead to losses of phase lock, which result in cycle slips. We have used data from the Canadian High Arctic Ionospheric Network (CHAIN to measure amplitude and phase scintillation from L1 GPS signals and total electron content (TEC from L1 and L2 GPS signals to study the relative role that various high-latitude irregularity generation mechanisms have in producing scintillation. In the first year of operation during the current solar minimum the amplitude scintillation has remained very low but events of strong phase scintillation have been observed. We have found, as expected, that auroral arc and substorm intensifications as well as cusp region dynamics are strong sources of phase scintillation and potential cycle slips. In addition, we have found clear seasonal and universal time dependencies of TEC and phase scintillation over the polar cap region. A comparison with radio instruments from the Canadian GeoSpace Monitoring (CGSM network strongly suggests that the polar cap scintillation and TEC variations are associated with polar cap patches which we therefore infer to be main contributors to scintillation-causing irregularities in the polar cap.

  17. Transition region of TEC enhancement phenomena during geomagnetically disturbed periods at mid-latitudes

    Directory of Open Access Journals (Sweden)

    K. Unnikrishnan

    2005-12-01

    Full Text Available Large-scale TEC perturbations/enhancements observed during the day sectors of major storm periods, 12-13 February 2000, 23 September 1999, 29 October 2003, and 21 November 2003, were studied using a high resolution GPS network over Japan. TEC enhancements described in the present study have large magnitudes (≥25×1016 electrons/m2 compared to the quiet-time values and long periods (≥120 min. The sequential manner of development and the propagation of these perturbations show that they are initiated at the northern region and propagate towards the southern region of Japan, with velocities >350 m/s. On 12 February 2000, remarkably high values of TEC and background content are observed at the southern region, compared to the north, because of the poleward expansion of the equatorial anomaly crest, which is characterized by strong latitudinal gradients near 35° N (26° N geomagnetically. When the TEC enhancements, initiating at the north, propagate through the region 39-34° N (30-25° N geomagnetically, they undergo transitions characterized by a severe decrease in amplitude of TEC enhancements. This may be due to their interaction with the higher background content of the expanded anomaly crest. However, at the low-latitude region, below 34° N, an increase in TEC is manifested as an enhanced ionization pattern (EIP. This could be due to the prompt penetration of the eastward electric field, which is evident from high values of the southward Interplanetary Magnetic Field component (IMF Bz and AE index. The TEC perturbations observed on the other storm days also exhibit similar transitions, characterized by a decreasing magnitude of the perturbation component, at the region around 39-34° N. In addition to this, on the other storm days, at the low-latitude region, below 34° N, an increase in TEC (EIP feature also indicates the repeatability of the above scenario. It is found that, the latitude and time at which the decrease in magnitude

  18. Transition region of TEC enhancement phenomena during geomagnetically disturbed periods at mid-latitudes

    Directory of Open Access Journals (Sweden)

    K. Unnikrishnan

    2005-12-01

    Full Text Available Large-scale TEC perturbations/enhancements observed during the day sectors of major storm periods, 12-13 February 2000, 23 September 1999, 29 October 2003, and 21 November 2003, were studied using a high resolution GPS network over Japan. TEC enhancements described in the present study have large magnitudes (≥25×1016 electrons/m2 compared to the quiet-time values and long periods (≥120 min. The sequential manner of development and the propagation of these perturbations show that they are initiated at the northern region and propagate towards the southern region of Japan, with velocities >350 m/s. On 12 February 2000, remarkably high values of TEC and background content are observed at the southern region, compared to the north, because of the poleward expansion of the equatorial anomaly crest, which is characterized by strong latitudinal gradients near 35° N (26° N geomagnetically. When the TEC enhancements, initiating at the north, propagate through the region 39-34° N (30-25° N geomagnetically, they undergo transitions characterized by a severe decrease in amplitude of TEC enhancements. This may be due to their interaction with the higher background content of the expanded anomaly crest. However, at the low-latitude region, below 34° N, an increase in TEC is manifested as an enhanced ionization pattern (EIP. This could be due to the prompt penetration of the eastward electric field, which is evident from high values of the southward Interplanetary Magnetic Field component (IMF Bz and AE index. The TEC perturbations observed on the other storm days also exhibit similar transitions, characterized by a decreasing magnitude of the perturbation component, at the region around 39-34° N. In addition to this, on the other storm days, at the low-latitude region, below 34° N, an increase in TEC (EIP feature also indicates the repeatability of the above scenario. It is found that, the latitude and

  19. Modeling of the Ionospheric Scintillation and Total Electron Content Observations during the 21 August 2017 Total Solar Eclipse

    Science.gov (United States)

    Datta-Barua, S.; Gachancipa, J. N.; Deshpande, K.; Herrera, J. A.; Lehmacher, G. A.; Su, Y.; Gyuk, G.; Bust, G. S.; Hampton, D. L.

    2017-12-01

    High concentration of free electrons in the ionosphere can cause fluctuations in incoming electromagnetic waves, such as those from the different Global Navigation Satellite Systems (GNSS). The behavior of the ionosphere depends on time and location, and it is highly influenced by solar activity. The purpose of this study is to determine the impact of a total solar eclipse on the local ionosphere in terms of ionospheric scintillations, and on the global ionosphere in terms of TEC (Total Electron Content). The studied eclipse occurred on 21 August 2017 across the continental United States. During the eclipse, we expected to see a decrease in the scintillation strength, as well as in the TEC values. As a broader impact part of our recently funded NSF proposal, we temporarily deployed two GNSS receivers on the eclipse's totality path. One GNSS receiver was placed in Clemson, SC. This is a multi-frequency GNSS receiver (NovAtel GPStation-6) capable of measuring high and low rate scintillation data as well as TEC values from four different GNSS systems. We had the receiver operating before, during, and after the solar eclipse to enable the comparison between eclipse and non-eclipse periods. A twin receiver collected data at Daytona Beach, FL during the same time, where an 85% partial solar eclipse was observed. Additionally, we set up a ground receiver onsite in the path of totality in Perryville, Missouri, from which the Adler Planetarium of Chicago launched a high-altitude balloon to capture a 360-degree video of the eclipse from the stratosphere. By analyzing the collected data, this study looks at the effects of partial and total solar eclipse periods on high rate GNSS scintillation data at mid-latitudes, which had not been explored in detail. This study also explores the impact of solar eclipses on signals from different satellite constellations (GPS, GLONASS, and Galileo). Throughout the eclipse, the scintillation values did not appear to have dramatic changes

  20. Time delay and duration of ionospheric total electron content responses to geomagnetic disturbances

    Directory of Open Access Journals (Sweden)

    J. Liu

    2010-03-01

    Full Text Available Although positive and negative signatures of ionospheric storms have been reported many times, global characteristics such as the time of occurrence, time delay and duration as well as their relations to the intensity of the ionospheric storms have not received enough attention. The 10 years of global ionosphere maps (GIMs of total electron content (TEC retrieved at Jet Propulsion Laboratory (JPL were used to conduct a statistical study of the time delay of the ionospheric responses to geomagnetic disturbances. Our results show that the time delays between geomagnetic disturbances and TEC responses depend on season, magnetic local time and magnetic latitude. In the summer hemisphere at mid- and high latitudes, the negative storm effects can propagate to the low latitudes at post-midnight to the morning sector with a time delay of 4–7 h. As the earth rotates to the sunlight, negative phase retreats to higher latitudes and starts to extend to the lower latitude toward midnight sector. In the winter hemisphere during the daytime and after sunset at mid- and low latitudes, the negative phase appearance time is delayed from 1–10 h depending on the local time, latitude and storm intensity compared to the same area in the summer hemisphere. The quick response of positive phase can be observed at the auroral area in the night-side of the winter hemisphere. At the low latitudes during the dawn-noon sector, the ionospheric negative phase responses quickly with time delays of 5–7 h in both equinoctial and solsticial months. Our results also manifest that there is a positive correlation between the intensity of geomagnetic disturbances and the time duration of both the positive phase and negative phase. The durations of both negative phase and positive phase have clear latitudinal, seasonal and magnetic local time (MLT dependence. In the winter hemisphere, long durations for the positive phase are 8–11 h and 12–14 h during the daytime at middle

  1. Adult thymic epithelial cell (TEC) progenitors and TEC stem cells: Models and mechanisms for TEC development and maintenance.

    Science.gov (United States)

    Hamazaki, Yoko

    2015-11-01

    The thymus is the primary lymphoid organ for generating self-restricted and self-tolerant functional T cells. Its two distinct anatomical regions, the cortex and the medulla, are involved in positive and negative selection, respectively. Thymic epithelial cells (TECs) constitute the framework of this tissue and function as major stromal components. Extensive studies for more than a decade have revealed how TECs are generated during organogenesis; progenitors specific for medullary TECs (mTECs) and cortical TECs (cTECs) as well as bipotent progenitors for both lineages have been identified, and the signaling pathways required for the development and maturation of mTECs have been elucidated. However, little is known about the initial commitment of mTECs and cTECs during ontogeny, and how regeneration of both lineages is sustained in the postnatal/adult thymus. Recently, stem cell activities in TECs have been demonstrated, and TEC progenitors have been identified in the postnatal thymus. In this review, recent advances in studying the development and maintenance of TECs are summarized, and the possible mechanisms of thymic regeneration and involution are discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Characteristics of equatorial plasma bubbles observed by TEC map based on ground-based GNSS receivers over South America

    Science.gov (United States)

    Barros, Diego; Takahashi, Hisao; Wrasse, Cristiano M.; Figueiredo, Cosme Alexandre O. B.

    2018-01-01

    A ground-based network of GNSS receivers has been used to monitor equatorial plasma bubbles (EPBs) by mapping the total electron content (TEC map). The large coverage of the TEC map allowed us to monitor several EPBs simultaneously and get characteristics of the dynamics, extension and longitudinal distributions of the EPBs from the onset time until their disappearance. These characteristics were obtained by using TEC map analysis and the keogram technique. TEC map databases analyzed were for the period between November 2012 and January 2016. The zonal drift velocities of the EPBs showed a clear latitudinal gradient varying from 123 m s-1 at the Equator to 65 m s-1 for 35° S latitude. Consequently, observed EPBs are inclined against the geomagnetic field lines. Both zonal drift velocity and the inclination of the EPBs were compared to the thermospheric neutral wind, which showed good agreement. Moreover, the large two-dimensional coverage of TEC maps allowed us to study periodic EPBs with a wide longitudinal distance. The averaged values observed for the inter-bubble distances also presented a clear latitudinal gradient varying from 920 km at the Equator to 640 km at 30° S. The latitudinal gradient in the inter-bubble distances seems to be related to the difference in the zonal drift velocity of the EPB from the Equator to middle latitudes and to the difference in the westward movement of the terminator. On several occasions, the distances reached more than 2000 km. Inter-bubble distances greater than 1000 km have not been reported in the literature.

  3. Synthesis and chemical etching of Te/C nanocables

    Indian Academy of Sciences (India)

    Abstract. In this paper, Te/C nanocables were fabricated by a hydrothermal method in the presence of cetyltrimethylammonium bromide (CTAB). The products were characterized in detail by multiform techniques: transmission electron microscopy, X-ray diffraction, energy-dispersive X-ray analysis and Fourier transform.

  4. TEcHNiCAL INNOVATION

    African Journals Online (AJOL)

    TEcHNiCAL INNOVATION. Anal venting after perianal surgery it ., Adeniran. Paediatric Surgery Unit, Department of Surgery, University of ilorin Teaching Hospital, ... Classification oiv anorectal malt'ormations~initial approach. Anal venting after perianal surgery. Adeniran J. O. diagnostic tests, and colostomy. Semin Pediatr ...

  5. The TEC Web-Umbrella

    NARCIS (Netherlands)

    Krom, J. G.; Korten, M.; Koslowski, H. R.; Kramer-Flecken, A.; Manduchi, G.; Niderost, B. U.; Oosterbeek, J. W.; Schorn, R. P.; Wijnoltz, F.; Becks, B.; Biel, W.; Evrard, M. P.; van Gorkom, J. C.; von Hellermann, M. G.

    2002-01-01

    The TEC community operates the TEXTOR device and in doing so collects and stores data from a number of different front-end acquisition systems, processing codes and analysis systems. Due to the evolution of these systems in the past, different, distributed data storage technologies were used to

  6. Discrimination of tsunamigenic earthquakes by ionospheric sounding using GNSS observations of total electron content from the Sumatran GPS Array

    Science.gov (United States)

    Manta, F.; Feng, L.; Occhipinti, G.; Taisne, B.; Hill, E.

    2017-12-01

    Tsunami earthquakes generate tsunamis larger than expected for their seismic magnitude. They rupture the shallow megathrust, which is usually at significant distance from land-based monitoring networks. This distance presents a challenge in accurately estimating the magnitude and source extent of tsunami earthquakes. Whether these parameters can be estimated reliably is critical to the success of tsunami early warning systems. In this work, we investigate the potential role of using GNSS-observed ionospheric total electron content (TEC) to discriminate tsunami earthquakes, by introducing for the first time the TEC Intensity Index (TECII) for rapidly identify tsunamigenic earthquakes. We examine two Mw 7.8 megathrust events along the Sumatran subduction zone with data from the Sumatran GPS Array (SuGAr). Both events triggered a tsunami alert that was canceled later. The Banyaks event (April 6th, 2010) did not generate a tsunami and caused only minor earthquake-related damage to infrastructure. On the contrary, the Mentawai event (October 25th, 2010) produced a large tsunami with run-up heights of >16 m along the southwestern coasts of the Pagai Islands. The tsunami claimed more than 400 lives. The primary difference between the two events was the depth of rupture: the Mentawai event ruptured a very shallow (earthquake (TECII = 1.14) and a characteristic signature of a tsunami 40 minutes after the event. These two signals reveal the large surface displacement at the rupture, and the consequent destructive tsunami. This comparative study of two earthquakes with the same magnitude at different depths highlights the potential role of ionospheric monitoring by GNSS to tsunami early warning systems

  7. 3D tomography of midlatitude sporadic-E in Japan from GNSS-TEC data

    Science.gov (United States)

    Muafiry, Ihsan Naufal; Heki, Kosuke; Maeda, Jun

    2018-03-01

    We studied ionospheric irregularities caused by midlatitude sporadic-E ( Es) in Japan using ionospheric total electron content (TEC) data from a dense GNSS array, GEONET, with a 3D (three-dimensional) tomography technique. Es is a thin layer of unusually high ionization that appears at altitudes of 100 km. Here, we studied five cases of Es irregularities in 2010 and 2012, also reported in previous studies, over the Kanto and Kyushu Districts. We used slant TEC residuals as the input and estimated the number of electron density anomalies of more than 2000 small blocks with dimensions of 20-30 km covering a horizontal region of 300 × 500 km. We applied a continuity constraint to stabilize the solution and performed several different resolution tests with synthetic data to assess the accuracy of the results. The tomography results showed that positive electron density anomalies occurred at the E region height, and the morphology and dynamics were consistent with those reported by earlier studies.

  8. PCA and vTEC climatology at midnight over mid-latitude regions

    Science.gov (United States)

    Natali, M. P.; Meza, A.

    2017-12-01

    The effect of the thermospheric vertical neutral wind on vertical total electron content (vTEC) variations including longitudinal anomaly, remaining winter anomaly, mid-latitude summer night anomaly, and semiannual anomaly is studied at mid-latitude regions around zero magnetic declination at midnight during high solar activity. By using the principal component analysis (PCA) numerical technique, this work studies the spatial and temporal variations of the ionosphere at midnight over mid-latitude regions during 2000-2002. PCA is applied to a time series of global vTEC maps produced by the International Global Navigation Satellite System (GNSS) Service. Four regions were studied in particular, each located at mid-latitude and approximately centered at zero magnetic declination, with two in the northern hemisphere and two in southern hemisphere, and all are located near and far from geomagnetic poles in each case. This technique provides an effective method to analyze the main ionospheric variabilities at mid-latitudes. PCA is also applied to the vTEC computed using the International Reference Ionosphere (IRI) 2012 model, to analyze the capability of this model to represent ionospheric variabilities at mid-latitude. Also, the Horizontal Wind Model 2007 (HWM07) is used to improve our climatology interpretation, by analyzing the relationship between vTEC and thermospheric wind, both quantitatively and qualitatively. At midnight, the behavior of mean vTEC values strongly responds to vertical wind variation, experiencing a decrease of about 10-15% with the action of the positive vertical component of the field-aligned neutral wind lasting for 2 h in all regions except for Oceania. Notable results include: a significant increase toward higher latitudes during summer in the South America and Asia regions, associated with the mid-latitude summer night anomaly, and an increase toward higher latitudes in winter in the North America and Oceania regions, highlighting the

  9. Study of TEC, slab-thickness and neutral temperature of the thermosphere in the Indian low latitude sector

    Directory of Open Access Journals (Sweden)

    K. Venkatesh

    2011-09-01

    Full Text Available The ionospheric equivalent slab-thickness is an important parameter which measures the skewness of the electron density profile of the ionosphere. In this paper, the diurnal, seasonal, day-to-day and latitudinal variations of ionospheric parameters namely total electron content (TEC, the peak ionization density of F-layer (NmF2, equivalent slab-thickness (τ and neutral temperature (Tn are presented. The simultaneous data of GPS-TEC and NmF2 from Trivandrum (8.47° N, 76.91° E, Waltair (17.7° N, 83.3° E and Delhi (28.58° N, 77.21° E are used to compute the slab-thickness (τ = TEC/NmF2 of the low sunspot period, 2004–2005. The day-time TEC values at Waltair are found to be greater than those at Trivandrum, while at Delhi the day-time TEC values are much lower compared to those at Trivandrum and Waltair. The trends of variation in the monthly mean diurnal variation of TEC and NmF2 are similar at Delhi, while they are different at Trivandrum and Waltair during the day-time. The slab-thickness (τ has shown a pre-sunrise peak around 05:00 LT at all the three stations, except during the summer months over Delhi. A consistent secondary peak in slab-thickness around noon hours has also been observed at Trivandrum and Waltair. During equinox and winter months a large night-time enhancement in the slab-thickness (comparable to the early morning peak in slab-thickness is observed at Delhi. The latitudinal variation of slab-thickness has shown a decrease from the equatorial station, Trivandrum to the low-mid latitude station, Delhi. The neutral temperatures (Tn computed from the slab-thickness (τ has shown a sharp increase around 05:00 LT over Trivandrum and Waltair. Whereas at Delhi, a double peaking around 05:00 and 23:00 LT is observed during winter and equinoctial months. The neutral temperatures computed are compare well with those of the MSIS-90 model derived temperatures.

  10. TEC – Thin Environmental Cladding

    Directory of Open Access Journals (Sweden)

    Alan Tomasi

    2015-05-01

    Full Text Available Permasteelisa Group developed with Fiberline Composites a new curtain wall system (Thin Environmental Cladding or TEC, making use of pultruded GFRP (Glass Fiber Reinforced Polymer material instead of traditional aluminum. Main advantages using GFRP instead of aluminum are the increased thermal performance and the limited environmental impact. Selling point of the selected GFRP resin is the light transmission, which results in pultruded profiles that allow the visible light to pass through them, creating great aesthetical effects. However, GFRP components present also weaknesses, such as high acoustic transmittance (due to the reduced weight and anisotropy of the material, low stiffness if compared with aluminum (resulting in higher facade deflection and sensible fire behavior (as combustible material. This paper will describe the design of the TEC-facade, highlighting the functional role of glass within the facade concept with regards to its acoustic, structural, aesthetics and fire behavior.

  11. Large enhancements in low latitude total electron content during 15 May 2005 geomagnetic storm in Indian zone

    Directory of Open Access Journals (Sweden)

    N. Dashora

    2009-05-01

    Full Text Available Results pertaining to the response of the equatorial and low latitude ionosphere to a major geomagnetic storm that occurred on 15 May 2005 are presented. These results are also the first from the Indian zone in terms of (i GPS derived total electron content (TEC variations following the storm (ii Local low latitude electrodynamics response to penetration of high latitude convection electric field (iii effect of storm induced traveling atmospheric disturbances (TAD's on GPS-TEC in equatorial ionization anomaly (EIA zone.

    Data set comprising of ionospheric TEC obtained from GPS measurements, ionograms from an EIA zone station, New Delhi (Geog. Lat. 28.42° N, Geog. Long. 77.21° E, ground based magnetometers in equatorial and low latitude stations and solar wind data obtained from Advanced Composition Explorer (ACE has been used in the present study. GPS receivers located at Udaipur (Geog. Lat. 24.73° N, Geog. Long. 73.73° E and Hyderabad (Geog. Lat. 17.33° N, Geog. Long. 78.47° E have been used for wider spatial coverage in the Indian zone. Storm induced features in vertical TEC (VTEC have been obtained comparing them with the mean VTEC of quiet days. Variations in solar wind parameters, as obtained from ACE and in the SYM-H index, indicate that the storm commenced on 15 May 2005 at 02:39 UT. The main phase of the storm commenced at 06:00 UT on 15 May with a sudden southward turning of the Z-component of interplanetary magnetic field (IMF-Bz and subsequent decrease in SYM-H index. The dawn-to-dusk convection electric field of high latitude origin penetrated to low and equatorial latitudes simultaneously as corroborated by the magnetometer data from the Indian zone. Subsequent northward turning of the IMF-Bz, and the penetration of the dusk-to-dawn electric field over the dip equator is also discernible. Response of the low latitude ionosphere to this storm may be characterized in terms of (i

  12. Performance evaluation of GIM-TEC assimilation of the IRI-Plas model at two equatorial stations in the American sector

    Science.gov (United States)

    Adebiyi, S. J.; Adebesin, B. O.; Ikubanni, S. O.; Joshua, B. W.

    2017-05-01

    Empirical models of the ionosphere, such as the International Reference Ionosphere (IRI) model, play a vital role in evaluating the environmental effect on the operation of space-based communication and navigation technologies. The IRI extended to Plasmasphere (IRI-Plas) model can be adjusted with external data to update its electron density profile while still maintaining the overall integrity of the model representations. In this paper, the performance of the total electron content (TEC) assimilation option of the IRI-Plas at two equatorial stations, Jicamarca, Peru (geographic: 12°S, 77°W, dip angle 0.8°) and Cachoeira Paulista, Brazil (Geographic: 22.7°S, 45°W, dip angle -26°), is examined during quiet and disturbed conditions. TEC, F2 layer critical frequency (foF2), and peak height (hmF2) predicted when the model is operated without external input were used as a baseline in our model evaluation. Results indicate that TEC predicted by the assimilation option generally produced smaller estimation errors compared to the "no extra input" option during quiet and disturbed conditions. Generally, the error is smaller at the equatorial trough than near the crest for both quiet and disturbed days. With assimilation option, there is a substantial improvement of storm time estimations when compared with quiet time predictions. The improvement is, however, independent on storm's severity. Furthermore, the modeled foF2 and hmF2 are generally poor with TEC assimilation, particularly the hmF2 prediction, at the two locations during both quiet and disturbed conditions. Consequently, IRI-Plas model assimilated with TEC value only may not be sufficient where more realistic instantaneous values of peak parameters are required.

  13. Long-term trends in the total electron content

    Czech Academy of Sciences Publication Activity Database

    Laštovička, Jan; Urbář, Jaroslav; Kozubek, Michal

    2017-01-01

    Roč. 44, č. 16 (2017), s. 8186-8172 ISSN 0094-8276 R&D Projects: GA ČR(CZ) GA15-03909S Institutional support: RVO:68378289 Keywords : total electron content * long-term trend * solar control Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Climatic research Impact factor: 4.253, year: 2016 http://onlinelibrary.wiley.com/doi/10.1002/2017GL075063/full

  14. Te/C nanocomposites for Li-Te Secondary Batteries

    Science.gov (United States)

    Seo, Jeong-Uk; Seong, Gun-Kyu; Park, Cheol-Min

    2015-01-01

    New battery systems having high energy density are actively being researched in order to satisfy the rapidly developing market for longer-lasting mobile electronics and hybrid electric vehicles. Here, we report a new Li-Te secondary battery system with a redox potential of ~1.7 V (vs. Li+/Li) adapted on a Li metal anode and an advanced Te/C nanocomposite cathode. Using a simple concept of transforming TeO2 into nanocrystalline Te by mechanical reduction, we designed an advanced, mechanically reduced Te/C nanocomposite electrode material with high energy density (initial discharge/charge: 1088/740 mA h cm-3), excellent cyclability (ca. 705 mA h cm-3 over 100 cycles), and fast rate capability (ca. 550 mA h cm-3 at 5C rate). The mechanically reduced Te/C nanocomposite electrodes were found to be suitable for use as either the cathode in Li-Te secondary batteries or a high-potential anode in rechargeable Li-ion batteries. We firmly believe that the mechanically reduced Te/C nanocomposite constitutes a breakthrough for the realization and mass production of excellent energy storage systems.

  15. Imaging Ionospheric Disturbances with a Global Array of the Ground-Based GPS TEC Receivers

    Science.gov (United States)

    Foster, J. C.; Coster, A.; Rideout, B.; Immel, T.; Rich, F. J.

    2004-05-01

    A prime example of distributed arrays of small instruments for space science research is found in the use of the existing global array of GPS receivers to provide high spatial/temporal resolution mapping of the total electron electron content (TEC) at equatorial, mid, auroral, and polar latitudes. Particularly dramatic effects are observed during major disturbances when magnetospheric electric fields perturb and redistribute the thermal plasmas of inner magnetosphere (plasmasphere/ionosphere). Enhancement and poleward displacement of the equatorial anomalies (EA), the formation of plasmaspheric drainage plumes which erode the outer plasmasphere and produce significant storm enhanced density and space weather effects at mid latitudes, and tongues of ionization which span the polar caps are all a part of the systematic redistribution of the low-latitude thermal plasma during strong events. The present distribution of GPS receivers permits mapping such features primarily over the land masses of North America and Europe, where 1x1 deg spatial and 30-sec temporal observations of vertical TEC can be achieved. Few receivers currently exist in developing countries and large gaps in coverage exist over the oceans. However, the large and meso-scale characteristics and evolution of these thermal plasma storm effects can be identified in the global maps. We address the cross-calibration of ground-based and space-based techniques to image and sample such features by comparing simultaneous observations of the major features observed during the strong storm on May 30, 2003. GPS TEC mapping observed the rapid enhancement of the EA and the formation of a concentration of enhanced plasma in the Carribean sector. This co-rotating enhancement provided a continuing a source for the dusk-sector plasmaspheric drainage plume. The down-looking IMAGE FUV instrument can map enhancements in the equatorial emissions associated with the EA and observed the spatial extent and evolution of the co

  16. Finding Multi-scale Connectivity in Our Geospace Observational System: A New Perspective for Total Electron Content Data Through Network Analysis

    Science.gov (United States)

    McGranaghan, R. M.; Mannucci, A. J.; Verkhoglyadova, O. P.; Malik, N.

    2017-12-01

    How do we evolve beyond current traditional methods in order to innovate into the future? In what disruptive innovations will the next frontier of space physics and aeronomy (SPA) be grounded? We believe the answer to these compelling, yet equally challenging, questions lies in a shift of focus: from a narrow, field-specific view to a radically inclusive, interdisciplinary new modus operandi at the intersection of SPA and the information and data sciences. Concretely addressing these broader themes, we present results from a novel technique for knowledge discovery in the magnetosphere-ionosphere-thermosphere (MIT) system: complex network analysis (NA). We share findings from the first NA of ionospheric total electron content (TEC) data, including hemispheric and interplanetary magnetic field clock angle dependencies [1]. Our work shows that NA complements more traditional approaches for the investigation of TEC structure and dynamics, by both reaffirming well-established understanding, giving credence to the method, and identifying new connections, illustrating the exciting potential. We contextualize these new results through a discussion of the potential of data-driven discovery in the MIT system when innovative data science techniques are embraced. We address implications and potentially disruptive data analysis approaches for SPA in terms of: 1) the future of the geospace observational system; 2) understanding multi-scale phenomena; and 3) machine learning. [1] McGranaghan, R. M., A. J. Mannucci, O. Verkhoglyadova, and N. Malik (2017), Finding multiscale connectivity in our geospace observational system: Network analysis of total electron content, J. Geophys. Res. Space Physics, 122, doi:10.1002/2017JA024202.

  17. Spatial analyses on seismo-ionospheric precursors observed by GIM TEC and DEMETER during the 2008 M8.0 Wenchuan earthquake

    Science.gov (United States)

    Liu, Jann-Yenq; Chen, Yuh-Ing; Huang, Ching-Chi; Parrot, Michel; Pulinets, Sergey; Ouzounov, Dimitar

    2015-04-01

    This paper examines seismo-ionospheric precursors (SIPs) in the total electron content (TEC) of the global ionosphere map (GIM) and observations in the French satellite DEMETER (Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions) during the 12 May 2008 M8.0 Wenchuan earthquake. The temporal and spatial analyses on the GIM TEC are used to search SIPs of the Wenchuan earthquake. Meanwhile, both daytime and nighttime electron density (Ne), electron temperature (Te), ion density (Ni) and ion temperature (Ti) probed by DEMETER are investigated. A statistical analysis of the box-and-whisker method is utilized to see if the four DEMETER data sets 1-6 days before and after the earthquake are significantly different. The analysis is employed to investigate the epicenter and three reference areas along the same magnetic latitude discriminating the SIPs from global effects. Results show that the nighttime Ne and Ni (daytime Ti) over the epicenter significantly decrease (increase) 1-6 days before the earthquake. The intersections of the global distribution of the significant differences (or anomalous changes) in the nighttime Ne, the nighttime Ni, and the daytime Ti 1-6 days before and after the earthquake specifically appear over the epicenter. The spatial analyses confirm that SIPs of GIM TEC and DEMETER observations appearing 2-6 days before are related to the 2008 M8.0 Wenchuan earthquake.

  18. The TEC Web-Umbrella

    International Nuclear Information System (INIS)

    Krom, J.G.; Korten, M.; Koslowski, H.R.; Kraemer-Flecken, A.; Manduchi, G.; Nideroest, B.U.; Oosterbeek, J.W.; Schorn, R.P.; Wijnoltz, F.; Becks, B.; Biel, W.; Evrard, M.P.; Gorkom, J.C. van; Hellermann, M.G. von

    2002-01-01

    The TEC community operates the TEXTOR device and in doing so collects and stores data from a number of different front-end acquisition systems, processing codes and analysis systems. Due to the evolution of these systems in the past, different, distributed data storage technologies were used to record this data. In an attempt to reduce the number of interfaces client codes have to use when accessing data from these data stores, an 'umbrella' concept was developed: a software-layer that covers (as an 'umbrella') as many as possible of these stores and provides a unified access mechanism to them. We explored the possibility of using the widely supported HTTP protocol for this purpose; this is the core protocol of the World-Wide-Web and it is capable of transporting almost any type of data. The concepts behind using this protocol were based on earlier work at JET. Access via this umbrella has been provided to the most important data stores around TEXTOR and access to others is being added regularly. Clients codes, libraries and programs have been developed for several user environments. The HTTP based concepts and the data-access via this system have been found to be highly portable. This paper gives an overview of the TEC Web-Umbrella system, it describes the basic concepts of this system and it presents some of the client-side codes and programs. The paper also reports on some first (tentative) user experiences with it

  19. TEC – Thin Environmental Cladding

    Directory of Open Access Journals (Sweden)

    Alan Tomasi

    2014-06-01

    Full Text Available Corresponding author: Alan Tomasi, Group R&D Project Manager, Permasteelisa S.p.A., viale E. Mattei 21/23 | 31029 Vittorio Veneto, Treviso, Italy. Tel.: +39 0438 505207; E-mail: a.tomasi@permasteelisagroup.com; www.permasteelisagroup.com Permasteelisa Group developed with Fiberline Composites a new curtain wall system (Thin Environmental Cladding or TEC, making use of pultruded GFRP (Glass Fiber Reinforced Polymer material instead of traditional aluminum. Main advantages using GFRP instead of aluminum are the increased thermal performance and the limited environmental impact. Selling point of the selected GFRP resin is the light transmission, which results in pultruded profiles that allow the visible light to pass through them, creating great aesthetical effects. However, GFRP components present also weaknesses, such as high acoustic transmittance (due to the reduced weight and anisotropy of the material, low stiffness if compared with aluminum (resulting in higher facade deflection and sensible fire behavior (as combustible material. This paper will describe the design of the TEC-facade, highlighting the functional role of glass within the facade concept with regards to its acoustic, structural, aesthetics and fire behavior.

  20. Modelling of Ionospheric Irregularities and Total Electron Content.

    Science.gov (United States)

    1983-12-01

    Total electron content changes 559, 1980. associated with equatorial irregularity plumes, Yeh, K.C., H. Soicher, C.H. Liu, and E. Bonelli , Paper...and GONZALES V. H. 1960 J. geophys. Res. 65, 3209. .,*’_*, YEn K. C., SOICHER H., Liu C. H. 1979a Geophys. Res. Lett. 6, 473. and BONELLI E.1,*,E Y K...and J. Aarons (1980), Studies of equatorial ir- Yeh. K. C., H. Soicher. C. H. Liu, and E. Bonelli (1979b). lono- regularity patches using SIRIO VHF

  1. Joint estimation of vertical total electron content (VTEC) and satellite differential code biases (SDCBs) using low-cost receivers

    Science.gov (United States)

    Zhang, Baocheng; Teunissen, Peter J. G.; Yuan, Yunbin; Zhang, Hongxing; Li, Min

    2018-04-01

    Vertical total electron content (VTEC) parameters estimated using global navigation satellite system (GNSS) data are of great interest for ionosphere sensing. Satellite differential code biases (SDCBs) account for one source of error which, if left uncorrected, can deteriorate performance of positioning, timing and other applications. The customary approach to estimate VTEC along with SDCBs from dual-frequency GNSS data, hereinafter referred to as DF approach, consists of two sequential steps. The first step seeks to retrieve ionospheric observables through the carrier-to-code leveling technique. This observable, related to the slant total electron content (STEC) along the satellite-receiver line-of-sight, is biased also by the SDCBs and the receiver differential code biases (RDCBs). By means of thin-layer ionospheric model, in the second step one is able to isolate the VTEC, the SDCBs and the RDCBs from the ionospheric observables. In this work, we present a single-frequency (SF) approach, enabling the joint estimation of VTEC and SDCBs using low-cost receivers; this approach is also based on two steps and it differs from the DF approach only in the first step, where we turn to the precise point positioning technique to retrieve from the single-frequency GNSS data the ionospheric observables, interpreted as the combination of the STEC, the SDCBs and the biased receiver clocks at the pivot epoch. Our numerical analyses clarify how SF approach performs when being applied to GPS L1 data collected by a single receiver under both calm and disturbed ionospheric conditions. The daily time series of zenith VTEC estimates has an accuracy ranging from a few tenths of a TEC unit (TECU) to approximately 2 TECU. For 73-96% of GPS satellites in view, the daily estimates of SDCBs do not deviate, in absolute value, more than 1 ns from their ground truth values published by the Centre for Orbit Determination in Europe.

  2. Evaluation of extreme ionospheric total electron content gradient associated with plasma bubbles for GNSS Ground-Based Augmentation System

    Science.gov (United States)

    Saito, S.; Yoshihara, T.

    2017-08-01

    Associated with plasma bubbles, extreme spatial gradients in ionospheric total electron content (TEC) were observed on 8 April 2008 at Ishigaki (24.3°N, 124.2°E, +19.6° magnetic latitude), Japan. The largest gradient was 3.38 TECU km-1 (total electron content unit, 1 TECU = 1016 el m-2), which is equivalent to an ionospheric delay gradient of 540 mm km-1 at the GPS L1 frequency (1.57542 GHz). This value is confirmed by using multiple estimating methods. The observed value exceeds the maximum ionospheric gradient that has ever been observed (412 mm km-1 or 2.59 TECU km-1) to be associated with a severe magnetic storm. It also exceeds the assumed maximum value (500 mm km-1 or 3.08 TECU km-1) which was used to validate the draft international standard for Global Navigation Satellite System (GNSS) Ground-Based Augmentation Systems (GBAS) to support Category II/III approaches and landings. The steepest part of this extreme gradient had a scale size of 5.3 km, and the front-normal velocities were estimated to be 71 m s-1 with a wavefront-normal direction of east-northeastward. The total width of the transition region from outside to inside the plasma bubble was estimated to be 35.3 km. The gradient of relatively small spatial scale size may fall between an aircraft and a GBAS ground subsystem and may be undetectable by both aircraft and ground.

  3. Methodology on sizing and selecting thermoelectric cooler from different TEC manufacturers in cooling system design

    International Nuclear Information System (INIS)

    Tan, F.L.; Fok, S.C.

    2008-01-01

    The search and selection for a suitable thermoelectric cooler (TEC) to optimize a cooling system design can be a tedious task as there are many product ranges from several TEC manufacturers. Although the manufacturers do provide proprietary manuals or electronic search facilities for their products, the process is still cumbersome as these facilities are incompatible. The electronic facilities often have different user interfaces and functionalities, while the manual facilities have different presentations of the performance characteristics. This paper presents a methodology to assist the designer to size and select the TECs from different manufacturers. The approach will allow designers to find quickly and to evaluate the devices from different TEC manufacturers. Based on the approach, the article introduces a new operational framework for an Internet based thermoelectric cooling system design process that would promote the interaction and collaboration between the designers and TEC manufacturers. It is hoped that this work would be useful for the advancement of future tools to assist designers to develop, analyze and optimize thermoelectric cooling system design in minimal time using the latest TECs available on the market

  4. Efficient Usage of Dense GNSS Networks in Central Europe for the Visualization and Investigation of Ionospheric TEC Variations.

    Science.gov (United States)

    Nykiel, Grzegorz; Zanimonskiy, Yevgen M; Yampolski, Yuri M; Figurski, Mariusz

    2017-10-10

    The technique of the orthogonal projection of ionosphere electronic content variations for mapping total electron content (TEC) allows us to visualize ionospheric irregularities. For the reconstruction of global ionospheric characteristics, numerous global navigation satellite system (GNSS) receivers located in different regions of the Earth are used as sensors. We used dense GNSS networks in central Europe to detect and investigate a special type of plasma inhomogeneities, called travelling ionospheric disturbances (TID). Such use of GNSS sensors allows us to reconstruct the main TID parameters, such as spatial dimensions, velocities, and directions of their movement. The paper gives examples of the restoration of dynamic characteristics of ionospheric irregularities for quiet and disturbed geophysical conditions. Special attention is paid to the dynamics of ionospheric disturbances stimulated by the magnetic storms of two St. Patrick's Days (17 March 2013 and 2015). Additional opportunities for the remote sensing of the ionosphere with the use of dense regional networks of GNSS receiving sensors have been noted too.

  5. Temporal and spatial variations in TEC using simultaneous measurements from the Indian GPS network of receivers during the low solar activity period of 2004–2005

    Directory of Open Access Journals (Sweden)

    P. V. S. Rama Rao

    2006-12-01

    Full Text Available With the recent increase in the satellite-based navigation applications, the ionospheric total electron content (TEC and the L-band scintillation measurements have gained significant importance. In this paper we present the temporal and spatial variations in TEC derived from the simultaneous and continuous measurements made, for the first time, using the Indian GPS network of 18 receivers located from the equator to the northern crest of the equatorial ionization anomaly (EIA region and beyond, covering a geomagnetic latitude range of 1° S to 24° N, using a 16-month period of data for the low sunspot activity (LSSA years of March 2004 to June 2005. The diurnal variation in TEC at the EIA region shows its steep increase and reaches its maximum value between 13:00 and 16:00 LT, while at the equator the peak is broad and occurs around 16:00 LT. A short-lived day minimum occurs between 05:00 to 06:00 LT at all the stations from the equator to the EIA crest region. Beyond the crest region the day maximum values decrease with the increase in latitude, while the day minimum in TEC is flat during most of the nighttime hours, i.e. from 22:00 to 06:00 LT, a feature similar to that observed in the mid-latitudes. Further, the diurnal variation in TEC show a minimum to maximum variation of about 5 to 50 TEC units, respectively, at the equator and about 5 to 90 TEC units at the EIA crest region, which correspond to range delay variations of about 1 to 8 m at the equator to about 1 to 15 m at the crest region, at the GPS L1 frequency of 1.575 GHz. The day-to-day variability is also significant at all the stations, particularly during the daytime hours, with maximum variations at the EIA crest regions. Further, similar variations are also noticed in the corresponding equatorial electrojet (EEJ strength, which is known to be one of the major contributors for the observed day-to-day variability in TEC. The seasonal variation in TEC maximizes during the equinox

  6. Modeling magnetic field and TEC signatures of large-amplitude acoustic and gravity waves generated by natural hazard events

    Science.gov (United States)

    Zettergren, M. D.; Snively, J. B.; Inchin, P.; Komjathy, A.; Verkhoglyadova, O. P.

    2017-12-01

    Ocean and solid earth responses during earthquakes are a significant source of large amplitude acoustic and gravity waves (AGWs) that perturb the overlying ionosphere-thermosphere (IT) system. IT disturbances are routinely detected following large earthquakes (M > 7.0) via GPS total electron content (TEC) observations, which often show acoustic wave ( 3-4 min periods) and gravity wave ( 10-15 min) signatures with amplitudes of 0.05-2 TECU. In cases of very large earthquakes (M > 8.0) the persisting acoustic waves are estimated to have 100-200 m/s compressional velocities in the conducting ionospheric E and F-regions and should generate significant dynamo currents and magnetic field signatures. Indeed, some recent reports (e.g. Hao et al, 2013, JGR, 118, 6) show evidence for magnetic fluctuations, which appear to be related to AGWs, following recent large earthquakes. However, very little quantitative information is available on: (1) the detailed spatial and temporal dependence of these magnetic fluctuations, which are usually observed at a small number of irregularly arranged stations, and (2) the relation of these signatures to TEC perturbations in terms of relative amplitudes, frequency, and timing for different events. This work investigates space- and time-dependent behavior of both TEC and magnetic fluctuations following recent large earthquakes, with the aim to improve physical understanding of these perturbations via detailed, high-resolution, two- and three-dimensional modeling case studies with a coupled neutral atmospheric and ionospheric model, MAGIC-GEMINI (Zettergren and Snively, 2015, JGR, 120, 9). We focus on cases inspired by the large Chilean earthquakes from the past decade (viz., the M > 8.0 earthquakes from 2010 and 2015) to constrain the sources for the model, i.e. size, frequency, amplitude, and timing, based on available information from ocean buoy and seismometer data. TEC data are used to validate source amplitudes and to constrain

  7. Global electron content: a new conception to track solar activity

    Directory of Open Access Journals (Sweden)

    E. L. Afraimovich

    2008-02-01

    Full Text Available We developed a method and programs for estimation of the global electron content (GEC from GPS measurements, using the ionosphere models IRI-2001 and NeQuick. During the 23rd cycle of solar activity, the value of GEC varied from 0.8 to 3.2×1032 electrons, following changes in the solar extreme ultra violet (EUV radiation and solar radio emission at 10.7-cm wavelength. We found a strong resemblance of these variations, with discernible 11-year and 27-day periodicities. A saturation effect of GEC is found when F10.7 increases. We found that GEC is characterized by strong seasonal (semiannual variations with maximum relative amplitude at about 10% during the rising and falling parts of the solar activity and up to 30% during the period of maximum. It was found that the relative difference between model and experimental GEC series increase as the smoothing time window decreases. We found that GEC-IRI seasonal variations are out-of-phase with experimental GEC values. The lag between model and experimental maximum of GEC values can reach several tens of days. The variations of GEC lag, on average, 2 days after those of F10.7 and UV. GEC completely reflects the dynamics of the active regions on the solar surface. The amplitude of the 27-day GEC variations decreases from 8% at the rising and falling solar activity to 2% at the maximum and at the minimum. We also found that the lifetime of contrast long-living active formations on the Sun's surface in EUV range for more than 1 month exceeds the one in radio range (10.7 cm.

  8. Global electron content: a new conception to track solar activity

    Directory of Open Access Journals (Sweden)

    E. L. Afraimovich

    2008-02-01

    Full Text Available We developed a method and programs for estimation of the global electron content (GEC from GPS measurements, using the ionosphere models IRI-2001 and NeQuick. During the 23rd cycle of solar activity, the value of GEC varied from 0.8 to 3.2×1032 electrons, following changes in the solar extreme ultra violet (EUV radiation and solar radio emission at 10.7-cm wavelength. We found a strong resemblance of these variations, with discernible 11-year and 27-day periodicities. A saturation effect of GEC is found when F10.7 increases. We found that GEC is characterized by strong seasonal (semiannual variations with maximum relative amplitude at about 10% during the rising and falling parts of the solar activity and up to 30% during the period of maximum. It was found that the relative difference between model and experimental GEC series increase as the smoothing time window decreases. We found that GEC-IRI seasonal variations are out-of-phase with experimental GEC values. The lag between model and experimental maximum of GEC values can reach several tens of days. The variations of GEC lag, on average, 2 days after those of F10.7 and UV. GEC completely reflects the dynamics of the active regions on the solar surface. The amplitude of the 27-day GEC variations decreases from 8% at the rising and falling solar activity to 2% at the maximum and at the minimum. We also found that the lifetime of contrast long-living active formations on the Sun's surface in EUV range for more than 1 month exceeds the one in radio range (10.7 cm.

  9. Characteristics of the ionospheric total electron content of the equatorial ionization anomaly in the Asian-Australian region during 1996–2004

    Directory of Open Access Journals (Sweden)

    Biqiang Zhao

    2009-10-01

    Full Text Available Ionospheric total electron content (TEC of the equatorial ionization anomaly (EIA is studied by analyzing dual-frequency signals of the Global Position System (GPS acquired from a network of receivers around the Asian-Australian region during 1996–2004. The latitude, occurrence time, strength of the most developed EIA crest, and crest-to-trough ratio (CTR for both the noon and post-sunset sector obtained from a daily TEC contour map have been used to study the solar cycle variations of EIA in the Asian-Australian region. The results reveal that semiannual and seasonal variations were the dominant factor that controls the morphology of the EIA structure which can be identified in the past studies (e.g. Wu et al., 2008. It is also found that the latitude and local time position of the anomaly crest show a hemispheric asymmetry because (a The northern crest of EIA is expanded during the equinox indicating a weak semiannual variation while the southern crest is inhibited during June–August presenting a strong seasonal variation, and (b The local time of the northern crest appears ~1.3 h earlier than that of the southern crest in June while showing no difference at December. Solar activity dependence is more evident in the EIA crest region than in the EIA trough region and least in the post-sunset sector at equinox. A seasonal linear relationship is derived between the post-sunset CTR and solar flux, which should be caused by the solar-dependant equatorial E×B vertical drift.

  10. Sugar and Aldehyde Content in Flavored Electronic Cigarette Liquids.

    Science.gov (United States)

    Fagan, Pebbles; Pokhrel, Pallav; Herzog, Thaddeus A; Moolchan, Eric T; Cassel, Kevin D; Franke, Adrian A; Li, Xingnan; Pagano, Ian; Trinidad, Dennis R; Sakuma, Kari-Lyn K; Sterling, Kymberle; Jorgensen, Dorothy; Lynch, Tania; Kawamoto, Crissy; Guy, Mignonne C; Lagua, Ian; Hanes, Sarah; Alexander, Linda A; Clanton, Mark S; Graham-Tutt, Camonia; Eissenberg, Thomas

    2017-11-22

    Sugars are major constituents and additives in traditional tobacco products, but little is known about their content or related toxins (formaldehyde, acetaldehyde, and acrolein) in electronic cigarette (e-cigarette) liquids. This study quantified levels of sugars and aldehydes in e-cigarette liquids across brands, flavors, and nicotine concentrations (n = 66). Unheated e-cigarette liquids were analyzed using liquid chromatography mass spectrometry and enzymatic test kits. Generalized linear models, Fisher's exact test, and Pearson's correlation coefficient assessed sugar, aldehyde, and nicotine concentration associations. Glucose, fructose and sucrose levels exceeded the limits of quantification in 22%, 53% and 53% of the samples. Sucrose levels were significantly higher than glucose [χ2(1) = 85.9, p regulation of specific flavor constituents in tobacco products as a strategy to protect young people from using e-cigarettes, while balancing FDA's interest in how these emerging products could potentially benefit adult smokers who are seeking to safely quit cigarette smoking. The data can also be used to educate consumers about ingredients in products that may contain nicotine and inform future FDA regulatory policies related to product standards and accurate and comprehensible labeling of e-cigarette liquids. © The Author 2017. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Positive and negative GPS-TEC ionospheric storm effects during the extreme space weather event of March 2015 over the Brazilian Sector

    Science.gov (United States)

    Fagundes, Paulo Roberto; Fejer, B. G.; Kavutarapu, Venkatesh; Gil Pillat, Valdir; Cardoso, Felipe Antonio; Ribeiro, Brunno Augusto

    2016-07-01

    We studied the response of the ionosphere (F-region) in the Brazilian sector during extreme space weather event of 17 March 2015 using a large network of 102 GPS-TEC stations. It is observed that the Vertical Total Electron Content (VTEC) was severely disturbed during the storm main and recovery phases. A wavelike oscillation with three peaks was observed in the TEC diurnal variation from equator to low latitudes during the storm main phase on 17th and 18th March, 2015. The latitudinal extent of the wavelike oscillation peaks decreased from the beginning of main phase towards the recovery phase. The first peak extended from beyond 0S to 30S, the second occurred from 6S to 25S, whereas the third diurnal peaks was confined from 13S to 25S. In addition, a strong negative phase in VTEC variations was observed during the recovery phase on March 18-19, 2015. This ionospheric negative phase was stronger at low-latitudes than in the equatorial region. Also, two latitudinal chains of GPS-TEC stations from equatorial region to low latitudes in the East and West Brazilian sectors are used to investigate the storm time behavior of the Equatorial Ionization Anomaly (EIA) in the East and West Brazilian sectors. We observed an anomalous behavior in EIA caused by the wavelike oscillations during the storm main phase on 17 March, and suppression of the EIA, resulting from the negative phase in VTEC, in the storm recovery phase.

  12. Observation of TEC perturbation associated with medium-scale traveling ionospheric disturbance and possible seeding mechanism of atmospheric gravity wave at a Brazilian sector

    Science.gov (United States)

    Jonah, O. F.; Kherani, E. A.; De Paula, E. R.

    2016-03-01

    In the present study, we document daytime total electron content (TEC) disturbances associated with medium-scale traveling ionospheric disturbances (MSTIDs), on few chosen geomagnetically quiet days over Southern Hemisphere of Brazilian longitude sector. These disturbances are derived from TEC data obtained using Global Navigation Satellite System (GNSS) receiver networks. From the keograms and cross-correlation maps, the TEC disturbances are identified as the MSTIDs that are propagating equatorward-eastward, having most of their average wavelengths longer in latitude than in longitude direction. These are the important outcomes of the present study which suggest that the daytime MSTIDs over Southern Hemisphere are similar to their counterparts in the Northern Hemisphere. Another important outcome is that the occurrence characteristics of these MSTIDs and that of atmospheric gravity wave (AGW) activities in the thermosphere are found to be similar on day-to-day basis. This suggests a possible connection between them, confirming the widely accepted AGW forcing mechanism for the generation of these daytime MSTIDs. The source of this AGW is investigated using the Geostationary Operational Environmental Satellite system (GOES) and Constellation Observing System for Meteorology, Ionosphere, and Climate satellite data. Finally, we provided evidences that AGWs are generated by convection activities from the tropospheric region.

  13. Localized field-aligned currents and 4-min TEC and ground magnetic oscillations during the 2015 eruption of Chile's Calbuco volcano

    Science.gov (United States)

    Aoyama, Tadashi; Iyemori, Toshihiko; Nakanishi, Kunihito; Nishioka, Michi; Rosales, Domingo; Veliz, Oscar; Safor, Erick Vidal

    2016-08-01

    The Calbuco volcano in southern Chile erupted on April 22, 2015. About 2 h after the first eruption, a Swarm satellite passed above the volcano and observed enhancement of small-amplitude (~0.5 nT) magnetic fluctuations with wave-packet structure which extends 15° in latitude. Similar wave packet is seen at the geomagnetic conjugate point of the volcano. Just after the eruption, geomagnetic fluctuations with the spectral peaks around the vertical acoustic resonance periods, 215 and 260 s, were also observed at Huancayo Geomagnetic Observatory located on the magnetic equator. Besides these observations, around 4-min, i.e., 175, 205 and 260 s, oscillations of total electron content (TEC) were observed at global positioning system stations near the volcano. The horizontal propagation velocity and the spatial scale of the TEC oscillation are estimated to be 720 m/s and 1600 km, respectively. These observations strongly suggest that the atmospheric waves induced by explosive volcanic eruption generate TEC variation and electric currents. The Swarm observation may be explained as a manifestation of their magnetic effects observed in the topside ionosphere.

  14. Dissecting and modeling the emergent murine TEC compartment during ontogeny.

    Science.gov (United States)

    Brunk, Fabian; Michel, Chloé; Holland-Letz, Tim; Slynko, Alla; Kopp-Schneider, Annette; Kyewski, Bruno; Pinto, Sheena

    2017-07-01

    The origin of the thymic epithelium, i.e. the cortical (cTEC) and medullary (mTEC) epithelial cells, from bipotent stem cells through TEC progenitors and lineage-specific progeny still remains poorly understood. We sought to obtain an unbiased view of the incipient emergence of TEC subsets by following embryonic TEC development based on co-expression of EpCAM, CD80 and MHC class II (MHCII) on non-hematopoietic (CD45 - ) thymic stromal cells in wild-type BL6 mice. Using a combination of ex vivo analysis, Re-aggregate Thymic Organ Culture (RTOC) reconstitution assays and mathematical modeling, we traced emergent lineage commitment in murine embryonic TECs. Both experimental and mathematical datasets supported the following developmental sequence: MHCII - CD80 - → MHCII lo CD80 - → MHCII hi CD80 - → MHCII hi CD80 hi TECs, whereby MHCII hi CD80 - and MHCII hi CD80 hi TECs bear features of cTECs and mTECs respectively. These emergent MHCII hi CD80 - cTECs directly generate mature MHCII hi CD80 hi mTECs in vivo and in vitro, thus supporting the asynchronous model of TEC lineage commitment. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Conformational snapshots of Tec kinases during signaling.

    Science.gov (United States)

    Joseph, Raji E; Andreotti, Amy H

    2009-03-01

    The control of cellular signaling cascades is of utmost importance in regulating the immune response. Exquisitely precise protein-protein interactions and chemical modification of substrates by enzymatic catalysis are the fundamental components of the signals that alert immune cells to the presence of a foreign antigen. In particular, the phosphorylation events induced by protein kinase activity must be spatially and temporally regulated by specific interactions to maintain a normal and effective immune response. High resolution structures of many protein kinases along with supporting biochemical data are providing significant insight into the intricate regulatory mechanisms responsible for controlling cellular signaling. The Tec family kinases are immunologically important kinases for which regulatory details are beginning to emerge. This review focuses on bringing together structural insights gained over the years to develop an understanding of how domain interactions both within the Tec kinases and between the Tec kinases and other signaling molecules control immune cell function.

  16. Comparison of GPS-TEC measurements with NeQuick2 and IRI model predictions in the low latitude East African region during varying solar activity period (1998 and 2008-2015)

    Science.gov (United States)

    Mengistu, E.; Damtie, B.; Moldwin, M. B.; Nigussie, M.

    2018-03-01

    This paper examines the performances of NeQuick2, the latest available IRI-2016, IRI-2012 and IRI-2007 models in describing the monthly and seasonal mean total electron content (TEC) over the East African region. This is to gain insight into the success of the various model types and versions at characterizing the ionosphere within the equatorial ionization anomaly. TEC derived from five Global Positioning System (GPS) receivers installed at Addis Ababa (ADD, 5.33°N, 111.99°E Geog.), Asab (ASAB, 8.67°N, 116.44°E Geog.), Ambo (ABOO, 5.43°N, 111.05°E Geog.), Nairobi (RCMN, -4.48°N, 108.46°E Geog.) and Nazret (NAZR, 4.78°N, 112.43°E Geog.), are compared with the corresponding values computed using those models during varying solar activity period (1998 and 2008-2015). We found that different models describe the equatorial and anomaly region ionosphere best depending on solar cycle, season and geomagnetic activity levels. Our results show that IRI-2016 is the best model (compared to others in terms of discrepancy range) in estimating the monthly mean GPS-TEC at NAZR, ADD and RCMN stations except at ADD during 2008 and 2012. It is also found that IRI-2012 is the best model in estimating the monthly mean TEC at ABOO station in 2014. IRI show better agreement with observations during June solstice for all the years studied at ADD except in 2012 where NeQuick2 better performs. At NAZR, NeQuick2 better performs in estimating seasonal mean GPS-TEC during 2011, while IRI models are best during 2008-2009. Both NeQuick2 and IRI models underestimate measured TEC for all the seasons at ADD in 2010 but overestimate at NAZR in 2009 and RCMN in 2008. The periodic variations of experimental and modeled TEC have been compared with solar and geomagnetic indices at ABOO and ASAB in 2014 and results indicate that the F10.7 and sunspot number as indices of solar activity seriously affects the TEC variations with periods of 16-32 days followed by the geomagnetic activity on

  17. Long term ionospheric electron content variations over Delhi

    Directory of Open Access Journals (Sweden)

    J. K. Gupta

    Full Text Available Ionospheric electron content (IEC observed at Delhi (geographic co-ordinates: 28.63°N, 77.22°E; geomagnetic co-ordinates: 19.08°N, 148.91°E; dip Latitude 24.8°N, India, for the period 1975–80 and 1986–89 belonging to an ascending phase of solar activity during first halves of solar cycles 21 and 22 respectively have been used to study the diurnal, seasonal, solar and magnetic activity variations. The diurnal variation of seasonal mean of IEC on quiet days shows a secondary peak comparable to the daytime peak in equinox and winter in high solar activity. IECmax (daytime maximum value of IEC, one per day shows winter anomaly only during high solar activity at Delhi. Further, IECmax shows positive correlation with F10.7 up to about 200 flux units at equinox and 240 units both in winter and summer; for greater F10.7 values, IECmax is substantially constant in all the seasons. IECmax and magnetic activity (Ap are found to be positively correlated in summer in high solar activity. Winter IECmax shows positive correlation with Ap in low solar activity and negative correlation in high solar activity in both the solar cycles. In equinox IECmax is independent of Ap in both solar cycles in low solar activity. A study of day-to-day variations in IECmax shows single day and alternate day abnormalities, semi-annual and annual variations controlled by the equatorial electrojet strength, and 27-day periodicity attributable to the solar rotation.

    Key words: Ionosphere (equatorial ionosphere · Magnetospheric physics (magnetosphere · ionosphere interactions · Radio science (ionospheric physics

  18. Stress signaling by Tec tyrosine kinase in the ischemic myocardium.

    Science.gov (United States)

    Zhang, Michael J; Franklin, Sarah; Li, Yifeng; Wang, Sujing; Ru, Xiaochen; Mitchell-Jordan, Scherise A; Mano, Hiroyuki; Stefani, Enrico; Ping, Peipei; Vondriska, Thomas M

    2010-09-01

    Nonreceptor tyrosine kinases have an increasingly appreciated role in cardiac injury and protection. To investigate novel tasks for members of the Tec family of nonreceptor tyrosine kinases in cardiac phenotype, we examined the behavior of the Tec isoform in myocardial ischemic injury. Ischemia-reperfusion, but not cardiac protective agents, induced altered intracellular localization of Tec, highlighting distinct actions of this protein compared with other isoforms, such as Bmx, in the same model. Tec is abundantly expressed in cardiac myocytes and assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP. To characterize Tec signaling targets in vivo, we performed an exhaustive proteomic analysis of Tec-binding partners. These experiments expand the role of the Tec family in the heart, identifying the Tec isoform as an ischemic injury-induced isoform, and map the subproteome of its interactors in isolated cells.

  19. Tec family kinases in inflammation and disease.

    Science.gov (United States)

    Horwood, Nicole J; Urbaniak, Ania M; Danks, Lynett

    2012-04-01

    Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.

  20. Ionospheric TEC from the Turkish Permanent GNSS Network (TPGN) and comparison with ARMA and IRI models

    Science.gov (United States)

    Ansari, Kutubuddin; Panda, Sampad Kumar; Althuwaynee, Omar F.; Corumluoglu, Ozsen

    2017-09-01

    The present study investigates the ionospheric Total Electron Content (TEC) variations in the lower mid-latitude Turkish region from the Turkish Permanent GNSS Network (TPGN) and International GNSS Services (IGS) observations during the year 2016. The corresponding vertical TEC (VTEC) predicted by Auto Regressive Moving Average (ARMA) and International Reference Ionosphere 2016 (IRI-2016) models are evaluated to realize their effectiveness over the region. The spatial, diurnal and seasonal behavior of VTEC and the relative VTEC variations are modeled with Ordinary Least Square Estimator (OLSE). The spatial behavior of modeled result during March equinox and June solstice indicates an inverse relationship of VTEC with the longitude across the region. On the other hand, the VTEC variation during September equinox and December solstice including March equinox and June solstice are decreasing with increase in latitude. The GNSS observed and modeled diurnal variation of the VTEC show that the VTEC slowly increases with dawn, attains a broader duration of peak around 09.00 to 12.00 UT, and thereafter decreases gradually reaching minimum around 21.00 UT. The seasonal variation of VTEC shows an annual mode, maxima in equinox and minima in solstice. The average value of VTEC during the June solstice is with slightly higher value than the March equinox though variations during the latter season is more. Moreover, the study shows minimum average value during December solstice compared to June solstice at all stations. The comparative analysis demonstrates the prediction errors by OLSE, ARMA and IRI remaining between 0.23 to 1.17%, 2.40 to 4.03% and 24.82 to 25.79% respectively. Also, the observed VTEC seasonal variation has good agreement with OLSE and ARMA models whereas IRI-VTEC often underestimated the observed value at each location. Hence, the deviations of IRI estimated VTEC compared to ARMA and OLSE models claim further improvements in IRI model over the Turkish region

  1. Recent Progress in Understanding Natural-Hazards-Generated TEC Perturbations: Measurements and Modeling Results

    Science.gov (United States)

    Komjathy, A.; Yang, Y. M.; Meng, X.; Verkhoglyadova, O. P.; Mannucci, A. J.; Langley, R. B.

    2015-12-01

    Natural hazards, including earthquakes, volcanic eruptions, and tsunamis, have been significant threats to humans throughout recorded history. The Global Positioning System satellites have become primary sensors to measure signatures associated with such natural hazards. These signatures typically include GPS-derived seismic deformation measurements, co-seismic vertical displacements, and real-time GPS-derived ocean buoy positioning estimates. Another way to use GPS observables is to compute the ionospheric total electron content (TEC) to measure and monitor post-seismic ionospheric disturbances caused by earthquakes, volcanic eruptions, and tsunamis. Research at the University of New Brunswick (UNB) laid the foundations to model the three-dimensional ionosphere at NASA's Jet Propulsion Laboratory by ingesting ground- and space-based GPS measurements into the state-of-the-art Global Assimilative Ionosphere Modeling (GAIM) software. As an outcome of the UNB and NASA research, new and innovative GPS applications have been invented including the use of ionospheric measurements to detect tiny fluctuations in the GPS signals between the spacecraft and GPS receivers caused by natural hazards occurring on or near the Earth's surface.We will show examples for early detection of natural hazards generated ionospheric signatures using ground-based and space-borne GPS receivers. We will also discuss recent results from the U.S. Real-time Earthquake Analysis for Disaster Mitigation Network (READI) exercises utilizing our algorithms. By studying the propagation properties of ionospheric perturbations generated by natural hazards along with applying sophisticated first-principles physics-based modeling, we are on track to develop new technologies that can potentially save human lives and minimize property damage. It is also expected that ionospheric monitoring of TEC perturbations might become an integral part of existing natural hazards warning systems.

  2. On the IRI 2007 performance as a TEC predictor for the South American sector

    Czech Academy of Sciences Publication Activity Database

    Scidá, L. A.; Ezquer, R. G.; Cabrera, M. A.; Mosert, M.; Brunini, C.; Burešová, Dalia

    81-82, June 2012 (2012), s. 50-58 ISSN 1364-6826 Institutional support: RVO:68378289 Keywords : IRI * ionosphere * TEC * GPS * electron density * topside Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 1.417, year: 2012 http://www.sciencedirect.com/science/article/pii/S1364682612001022

  3. Observations of magnetic field and TEC fluctuations caused by ionospheric responses to acoustic and gravity waves from ground-level, natural hazard sources

    Science.gov (United States)

    Inchin, P.; Zettergren, M. D.; Snively, J. B.; Komjathy, A.; Verkhoglyadova, O. P.

    2017-12-01

    Recent studies have reported magnetic field fluctuations following intense seismic hazard events [e.g. Aoyama et al., EPS, 68, 2016; Toh et al., JGR, 116, 2011]. These perturbations can be associated with ionospheric dynamo phenomena driven by seismically generated acoustic and gravity waves (AGWs). AGW-related dynamo effects can be separated from other sources of magnetic fluctuations (e.g. piezo magnetic effects, magnetospheric forcing or Rayleigh surface waves) based on time delays from event onset (corresponding closely with travel times for AGWs from ground to the ionosphere) and spectral content measured concurrently in total electron content (TEC). Modeling studies aimed at understanding these magnetic field fluctuations have demonstrated the idea that AGWs propagating through the conducting ionosphere can induce current densities sufficient to produce observable magnetic signatures [Zettergren and Snively, JGR, 120, 2017]. Here, we investigate the features of seismic-related magnetic field fluctuations in data and their generation via the effects of seismically-forced AGWs on the ionosphere [Iyemori et al., EPS, 65, 2013; Hasbi et al., JASTP, 71, 2005]. Concurrent magnetic field and TEC data are analyzed for several events: the Chilean earthquakes of 2010 and 2015, Chile's Calbuco volcano eruption and the Sumatran earthquake on March 28, 2005. We investigate the qualitative features of the disturbances as well as quantitative spectral and timing analysis of the data. For Chilean earthquakes, TEC and ground-based magnetometer data reveal fluctuations in magnetic field exhibiting 4-5 mHz frequencies, the same as in TEC. For the Calbuco volcano eruption and Sumatran earthquake both TEC and magnetic field perturbations exhibit frequencies of 4-5 mHz. The results are consistent with previous reports [Aoyama et al., EPS, 68, 2016, Hasbi et al., JASTP, 71, 2005, Iyemori et al., EPS, 65, 2013]. These observations are further interpreted through detailed numerical

  4. Observations by the CUTLASS radar, HF Doppler, oblique ionospheric sounding, and TEC from GPS during a magnetic storm

    Directory of Open Access Journals (Sweden)

    D. V. Blagoveshchensky

    2005-07-01

    Full Text Available Multi-diagnostic observations, covering a significant area of northwest Europe, were made during the magnetic storm interval (28–29 April 2001 that occurred during the High Rate SolarMax IGS/GPS-campaign. HF radio observations were made with vertical sounders (St. Petersburg and Sodankyla, oblique incidence sounders (OIS, on paths from Murmansk to St. Petersburg, 1050 km, and Inskip to Leicester, 170 km, Doppler sounders, on paths from Cyprus to St. Petersburg, 2800 km, and Murmansk to St. Petersburg, and a coherent scatter radar (CUTLASS, Hankasalmi, Finland. These, together with total electron content (TEC measurements made at GPS stations from the Euref network in northwest Europe, are presented in this paper. A broad comparison of radio propagation data with ionospheric data at high and mid latitudes, under quiet and disturbed conditions, was undertaken. This analysis, together with a geophysical interpretation, allow us to better understand the nature of the ionospheric processes which occur during geomagnetic storms. The peculiarity of the storm was that it comprised of three individual substorms, the first of which appears to have been triggered by a compression of the magnetosphere. Besides the storm effects, we have also studied substorm effects in the observations separately, providing an improved understanding of the storm/substorm relationship. The main results of the investigations are the following. A narrow trough is formed some 10h after the storm onset in the TEC which is most likely a result of enhanced ionospheric convection. An enhancement in TEC some 2–3 h after the storm onset is most likely a result of heating and upwelling of the auroral ionosphere caused by enhanced currents. The so-called main effect on ionospheric propagation was observed at mid-latitudes during the first two substorms, but only during the first substorm at high latitudes. Ionospheric irregularities observed by CUTLASS were clearly related to the

  5. EDUCATION AND VOCATIONAL TRAINING OF TEC CLAIMANTS.

    Science.gov (United States)

    Indiana State Employment Security Div., Indianapolis.

    TO COLLECT INFORMATION CONCERNING THE PERSONAL CHARACTERISTICS, FAMILY STATUS, EDUCATION AND VOCATIONAL TRAINING, WORK HISTORY, AND UNEMPLOYMENT EXPERIENCE OF TEMPORARY EXTENDED UNEMPLOYMENT COMPENSATION (TEC) CLAIMANTS IN INDIANA, A QUESTIONNAIRE-INTERVIEW WAS ADMINISTERED TO A 5 PERCENT SAMPLE OF PERSONS FILING CLAIMS DURING 3 SELECTED WEEKS,…

  6. GPS-TEC Observation of Gravity Waves Generated in the Ionosphere During 21 August 2017 Total Solar Eclipse

    Science.gov (United States)

    Nayak, Chinmaya; Yiǧit, Erdal

    2018-01-01

    The present work investigates ionospheric effects of the 21 August 2017 total solar eclipse, particularly targeting eclipse-generated gravity waves in the ionosphere. Ionospheric total electron content (TEC) derived from Global Positioning System (GPS) data obtained from a number of stations located both along and across the path of eclipse totality has been utilized for this purpose. Distinct gravity wave-like signatures with wave periods around 20-90 min (with dominant peak at 25-30 min wave period) have been observed at all locations both in the path of totality and away from it. The observed gravity waves are more intense at locations closer to the path of totality, and the wave amplitudes decrease gradually with increasing distance from the path of totality. Our result highlights the manifestation of eclipse-generated waves in the variability of the terrestrial ionosphere.

  7. analysis of the content of human atria Electron microscopic specific ...

    African Journals Online (AJOL)

    1990-08-18

    Aug 18, 1990 ... tron microscopic analysis of the atrial granule content was used to study 12 patients - 5 with mitral stenosis and sinus rhythm, 3 with mitral stenosis and atrial fibrillation and 4 controls. Granules were counted using a free count and montage method. This is the first report of such a morphometric analysis in.

  8. Latitudinal variations of TEC over Europe obtained from GPSobservations

    Directory of Open Access Journals (Sweden)

    P. Wielgosz

    2004-01-01

    Full Text Available GPS technique has opened broad possibilities to study the TEC distribution on a regular basis. In this paper, the latitudinal dependence of TEC over Europe for geographic latitudes ranging from 40°N to 75°N is presented. We discuss the day-to-day variations of the latitudinal TEC profiles for a period of 1999 to 2001 for both quiet and disturbed magnetic conditions. More than 4300 TEC profiles were created from the TEC maps with a one-hour interval. GPS data from 65 European permanent stations were used to produce the TEC maps. The comparison of GPS-derived TEC profiles with the IRI model is also discussed. Key words. Ionosphere (mid-latitude ionosphere; ionospheric disturbances

  9. Distributions of TEC Fluctuations and Losses of Lock Associated with Equatorial Plasma Bubbles

    Science.gov (United States)

    Nakata, H.; Kikuchi, H.; Tsugawa, T.; Otsuka, Y.; Takano, T.; Shimakura, S.; Shiokawa, K.; Ogawa, T.

    2009-12-01

    Equatorial plasma bubbles (EPBs) are local depletions of the electron density in the ionosphere. Due to field-aligned irregularities (FAIs) with various spatial scales, EPBs affect wide-band radio waves and cause scintillations in GPS navigation system. Strong scintillation can cause a GPS receiver to lose lock on GPS signals because of rapid variations of signal amplitude and phase, and limit the availability of carrier phase measurements. Since the scintillation is caused by Fresnel diffraction, the spatial scale of FAIs that causes the scintillation of GPS signals is about 2-300 m. Therefore, loss of phase lock (LOL) on GPS signals is a reference of hundred-meter-scale FAIs. As EPBs are also associated with fluctuations of the total electron content (TEC), the enhancement of Rate of TEC change index (ROTI) occurs around EPBs. Assuming that the altitude of the ionosphere is about 400 km, the velocity of the pierce point of the GPS radio wave at the ionospheric altitude is approximately 70 m/s around the zenith. Thus, ROTI averaged during 5 minutes is a reference of ten-kilometer-scale fluctuations. In this study, we analyzed LOL and 5-min. ROTI associated with EPBs to examine the spatial and temporal scales of electron density disturbances associated with EPBs. We selected 11 EPBs from 630-nm airglow images obtained by all-sky imager at Sata, Japan, in 2001. LOL and ROTI are obtained from GPS data from GPS Earth Observation Network (GEONET) of Japan, which consists of more than 1000 GPS receivers. As a result, it is shown that both LOL and the enhancement of ROTI are observed in 8 events out of 11 events. The distributions of LOL are approximately consistent with the areas in which the ionospheric electron density is depleted. The enhancements of ROTI are observed in the vicinities of EPBs. The enhancement of ROTI expands especially in the west side of EPBs. After the EPBs pass through, therefore, LOLs are vanished but the enhancements of ROTI last a while. This

  10. Practical use technology of coal ash (Poz-O-Tec); Sekitanbai no yuko riyo gijutsu (POZ-O-TEC)

    Energy Technology Data Exchange (ETDEWEB)

    Konno, K. [Center for Coal Utilization, Japan, Tokyo (Japan); Saito, Y. [Mitsui Mining Co. Ltd., Tokyo (Japan); Nagaya, Y. [Mitsui Construction Co. Ltd., Tokyo (Japan)

    1996-09-01

    In order to utilize more effectively coal ash whose generation amount is increasing year after year, studies have been made on a technology to manufacture and utilize a high-strength substance solidified under normal temperature by utilizing hydration reaction of pozzolan system (Poz-O-Tec). The study works have been done as a subsidy operation of the Agency of Natural Resources and Energy, and were completed in fiscal 1995. Poz-O-Tec is a wet powder made of coal ash and stack gas desulfurization sludge (gypsum) added and mixed with lime and an adequate amount of water, which solidifies by hydration as pozzolan does. The same method as used for ordinary sands may be used as the basic application method. Because this is the material whose strength increases after construction, thickness of construction may be reduced smaller than in constructions using soils and sands. Test constructions of about sixty cases have been carried out to date, typically represented in use as a road bed material, banking, and a base material for water-barrier gutters. High-strength solid material which is stable under normal temperature may be obtained by adjusting calcium content. As a result of its effectiveness in practical use having been verified, a certificate of technological judgment has been issued for the material by the Civil Engineering Research Center. 3 refs., 11 figs., 2 tabs.

  11. Strengths and weaknesses of electronic referral: comparison of data content and clinical value of electronic and paper referrals in dermatology

    Science.gov (United States)

    Shaw, Lindsay J; de Berker, David AR

    2007-01-01

    One hundred and thirty-one electronic referrals and 129 paper referrals were reviewed and their content analysed. Four items of demographic data were better recorded in the electronic referrals. Three items of clinical data were significantly better recorded in the paper referrals. The mean global clinical score for clinical relevance was greater for paper referrals than electronic referrals. This study illustrates the strength of electronic referrals for communicating demographic data and their weakness when revealing what is wrong with the patient. PMID:17359610

  12. "Smoking revolution": a content analysis of electronic cigarette retail websites.

    Science.gov (United States)

    Grana, Rachel A; Ling, Pamela M

    2014-04-01

    Electronic cigarettes (e-cigarettes) have been increasingly available and marketed in the U.S. since 2007. As patterns of product adoption are frequently driven and reinforced by marketing, it is important to understand the marketing claims encountered by consumers. To describe the main advertising claims made on branded e-cigarette retail websites. Websites were retrieved from two major search engines in 2011 using iterative searches with the following terms: electronic cigarette, e-cigarette, e-cig, and personal vaporizer. Fifty-nine websites met inclusion criteria, and 13 marketing claims were coded for main marketing messages in 2012. Ninety-five percent of the websites made explicit or implicit health-related claims, 64% had a smoking cessation-related claim, 22% featured doctors, and 76% claimed that the product does not produce secondhand smoke. Comparisons to cigarettes included claims that e-cigarettes were cleaner (95%) and cheaper (93%). Eighty-eight percent stated that the product could be smoked anywhere and 71% mentioned using the product to circumvent clean air policies. Candy, fruit, and coffee flavors were offered on most sites. Youthful appeals included images or claims of modernity (73%); increased social status (44%); enhanced social activity (32%); romance (31%); and use by celebrities (22%). Health claims and smoking-cessation messages that are unsupported by current scientific evidence are frequently used to sell e-cigarettes. Implied and overt health claims, the presence of doctors on websites, celebrity endorsements, and the use of characterizing flavors should be prohibited. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  13. A content analysis of electronic cigarette manufacturer websites in China

    Science.gov (United States)

    Yao, Tingting; Jiang, Nan; Grana, Rachel; Ling, Pamela M; Glantz, Stanton A

    2014-01-01

    Objective The goal of this study was to summarise the websites of electronic cigarette (e-cigarette) manufacturers in China and describe how they market their products. Methods From March to April 2013, we used two search keywords ‘electronic cigarette’ (Dian Zi Xiang Yan in Chinese) and ‘manufacturer’ (Sheng Chan Chang Jia in Chinese) to search e-cigarette manufacturers in China on Alibaba, an internet-based e-commerce business that covers business-to-business online marketplaces, retail and payment platforms, shopping search engine and data-centric cloud computing services. A total of 18 websites of 12 e-cigarette manufacturers in China were analysed by using a coding guide which includes 14 marketing claims. Results Health-related benefits were claimed most frequently (89%), followed by the claims of no secondhand smoke (SHS) exposure (78%), and utility for smoking cessation (67%). A wide variety of flavours, celebrity endorsements and e-cigarettes specifically for women were presented. None of the websites had any age restriction on access, references to government regulation or lawsuits. Instruction on how to use e-cigarettes was on 17% of the websites. Conclusions Better regulation of e-cigarette marketing messages on manufacturers’ websites is needed in China. The frequent claims of health benefits, smoking cessation, strategies appealing to youth and women are concerning, especially targeting women. Regulators should prohibit marketing claims of health benefits, no SHS exposure and value for smoking cessation in China until health-related, quality and safety issues have been adequately addressed. To avoid e-cigarette use for initiation to nicotine addiction, messages targeting youth and women should be prohibited. PMID:25335902

  14. A content analysis of electronic cigarette manufacturer websites in China.

    Science.gov (United States)

    Yao, Tingting; Jiang, Nan; Grana, Rachel; Ling, Pamela M; Glantz, Stanton A

    2016-03-01

    The goal of this study was to summarise the websites of electronic cigarette (e-cigarette) manufacturers in China and describe how they market their products. From March to April 2013, we used two search keywords 'electronic cigarette' (Dian Zi Xiang Yan in Chinese) and 'manufacturer' (Sheng Chan Chang Jia in Chinese) to search e-cigarette manufacturers in China on Alibaba, an internet-based e-commerce business that covers business-to-business online marketplaces, retail and payment platforms, shopping search engine and data-centric cloud computing services. A total of 18 websites of 12 e-cigarette manufacturers in China were analysed by using a coding guide which includes 14 marketing claims. Health-related benefits were claimed most frequently (89%), followed by the claims of no secondhand smoke (SHS) exposure (78%), and utility for smoking cessation (67%). A wide variety of flavours, celebrity endorsements and e-cigarettes specifically for women were presented. None of the websites had any age restriction on access, references to government regulation or lawsuits. Instruction on how to use e-cigarettes was on 17% of the websites. Better regulation of e-cigarette marketing messages on manufacturers' websites is needed in China. The frequent claims of health benefits, smoking cessation, strategies appealing to youth and women are concerning, especially targeting women. Regulators should prohibit marketing claims of health benefits, no SHS exposure and value for smoking cessation in China until health-related, quality and safety issues have been adequately addressed. To avoid e-cigarette use for initiation to nicotine addiction, messages targeting youth and women should be prohibited. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  15. Content barriers to pediatric uptake of electronic health records.

    Science.gov (United States)

    Gracy, Delaney; Weisman, Jeb; Grant, Roy; Pruitt, Jennifer; Brito, Arturo

    2012-01-01

    EHR systems provide significant opportunities to enhance pediatric care. Well-constructed clinical content, HIE, automated reminders and alerts, and reporting at practice, community, and public health levels are available in several current systems and products. However, the general focus on inpatient and adult populations in the design and marketing of these systems should be seen as a significant barrier to EHR adoption among pediatric primary care providers. Weight-based medication dosing, specialty growth charts, units of measurement and time, and measures to address minor consent and adolescent confidentiality are not universal in quality and availability to the pediatric practice. However, there are opportunities for pediatricians to provide input and to clearly state minimum requirements when dealing with vendors or when government agencies (eg, ONCHIT and AHRQ) seek comment on standards, practices, and expectations. This article uses cases and examples to describe some areas in which pediatricians should take an active role to advocate for pediatric-appropriate EHR tools. Virtually every child born and cared for in the United States today will have their data and information recorded in an EHR. The quality of the information and the HIT in which it is recorded can affect the care they get as children, and the information they carry into adulthood.

  16. Exploring Barriers to the Categorization of Electronic Content in a Global Professional Services Firm

    Science.gov (United States)

    Totterdale, Robert L.

    2009-01-01

    Businesses have always maintained records pertinent to the enterprise. With over 90% of new business records now estimated to be available in electronic form, organizations struggle to manage these vast amounts of electronic content while at the same time meeting collaboration, knowledge management, regulatory, and compliance needs. This case…

  17. Detection of ionospheric signatures from GPS-derived total electron content maps

    DEFF Research Database (Denmark)

    Durgonics, Tibor; Prates, G.; Berrocoso, M.

    2014-01-01

    . After validation of these periodic phenomena, detection of non-periodic changes, such as solar flares and tectonic interactions with the ionosphere were attempted. The results showed a TEC increase following a selected solar flare event and a potential TEC build-up prior to the 2011 Lorca earthquake....... Further studies could open up the possibility of building early warning systems. The presented methods, based on available software packages, are also of value in monitoring the effect of the ionosphere on radio signals, satellite and mobile communication, power grids, and for accurate GNSS navigation....

  18. GNSS-TEC observations of the atmospheric resonance excited by the 2015 April Plinian eruptions of the Calbuco volcano, Chile: Comparison with the 2014 Kelud eruption

    Science.gov (United States)

    Nakashima, Y.; Heki, K.

    2015-12-01

    GNSS-Total Electron Content (TEC) method is a useful tool to observe the ionosphere. We observed ionospheric disturbances caused by the lower atmospheric resonance excited by two recent Plinian volcanic eruptions. In the case of the 2014 eruption of the Kelud volcano, Indonesia (Nakashima et al., submitted), the lower atmospheric resonance excited by the continuing eruption caused long-lasting harmonic oscillations not only in the ionosphere but also in the solid earth. This year, we add the new case of the 2015 eruption of the Calbuco volcano, Chile. Two large eruptions occurred at the Calbuco volcano over the days 22- 23 April 2015. The first sub-Plinian eruption started at ~16:04 UT, Apr. 22, and continued for about 1.5 hours. The second one started at ~4:00 UT, Apr. 23, and lasted for 6 hours. We detected continuous oscillations of ionospheric TEC corresponding to the two eruptions using GPS and GLONASS data from stations of the Argentine GNSS Array: RAMSAC. The waves propagated with a speed of ~1.0 km/s from the volcano. The frequency spectra of the TEC variation in the first eruption on Apr. 22 showed clear peaks at 3.7 and 4.4 mHz, the lower atmospheric resonance frequencies. The perturbation also showed overtone peaks and a 10 mHz pulse-like signal at the onset of the continuous oscillation. The results suggest that a Vulcanian explosion occurred prior to the Plinian eruption. On the other hand, the second eruption on Apr. 23 showed only a weaker peak at 4.4 mHz without overtones, suggesting that the second eruption was weaker but lasted longer than the first one. We are going to present detailed records of the 2015 Calbuco case, and compare it with past cases of ionospheric disturbances by volcanic eruptions, e.g. the 2014 Kelud volcano eruption.

  19. Test and Evaluation of Training Extension Course (TEC).

    Science.gov (United States)

    Jacobs, T. O.; Hardy, Richard A., Jr.

    The effectiveness of a Training Extension Course (TEC) as a means of increasing the Military Occupational Specialty (MOS) proficiency of Army personnel was evaluated. TEC was implemented by the Combat Arms Training Board using sound/slide as the basic media for 56 lessons. Training material relevant to MOS 11B40, Light Weapons Infantryman, was…

  20. The protein tyrosine kinase Tec regulates mast cell function.

    Science.gov (United States)

    Schmidt, Uwe; Abramova, Anastasia; Boucheron, Nicole; Eckelhart, Eva; Schebesta, Alexandra; Bilic, Ivan; Kneidinger, Michael; Unger, Bernd; Hammer, Martina; Sibilia, Maria; Valent, Peter; Ellmeier, Wilfried

    2009-11-01

    Mast cells play crucial roles in a variety of normal and pathophysiological processes and their activation has to be tightly controlled. Here, we demonstrate that the protein tyrosine kinase Tec is a crucial regulator of murine mast cell function. Tec was activated upon Fc epsilon RI stimulation of BM-derived mast cells (BMMC). The release of histamine in the absence of Tec was normal in vitro and in vivo; however, leukotriene C(4) levels were reduced in Tec(-) (/) (-) BMMC. Furthermore, the production of IL-4 was severely impaired, and GM-CSF, TNF-alpha and IL-13 levels were also diminished. Finally, a comparison of WT, Tec(-) (/) (-), Btk(-) (/) (-) and Tec(-) (/) (-)Btk(-) (/) (-) BMMC revealed a negative role for Btk in the regulation of IL-4 production, while for the efficient production of TNF-alpha, IL-13 and GM-CSF, both Tec and Btk were required. Our results demonstrate a crucial role for Tec in mast cells, which is partially different to the function of the well-characterized family member Btk.

  1. GPS based TEC measurements for a period August 2008 ...

    Indian Academy of Sciences (India)

    current low sunspot activity periods). These TEC values correspond to range delay variations of about. 1 to 9 m at Surat. These variations in the range delay will certainly increase in high sunspot activity periods. Detected TEC variations are also closely related to space weather characterizing quantities such as solar wind ...

  2. A picture is worth a thousand words: Electronic cigarette content on Instagram and Pinterest

    OpenAIRE

    Alexander S. Lee; Joy L. Hart; Clara G Sears; Kandi L Walker; Allison Siu; Courteney Smith

    2017-01-01

    Introduction This study examined electronic cigarette (e-cig) content in visual materials posted on the social-media platforms Instagram and Pinterest. Both platforms allow users to upload pictures to the internet and share them globally. Users can search for pictures tagged with specific keywords and phrases. Methods Using content analysis, this study identified themes in image postings of e-cigs on social media. During five weeks of data collection, keywords were used ...

  3. TEC and ultralloys for high-power space systems

    International Nuclear Information System (INIS)

    Morris, J.F.; Jacobson, D.L.

    1985-01-01

    Increasing space-nuclear-reactor (SNR) power requirements force system weights -- and temperatures -- upward. For such growth thermionic energy conversion (TEC) excels in SNR service between tenths of a megawatt and about ten megawatts. But TEC yields much current at low voltage. And as total outputs soar, radiators at 400K for conventional power conditioning (PC) balloon compared with those at 1000K and higher for TEC itself. To reduce PC problems TEC requires contiguous high-temperature inversion or internal electromagnetic-wave generation. Both are possible, potentially practical and probably exploitable through research. However attaining suitable efficiencies with these different operating modes and higher rejection temperatures demands new electrode and additive technologies as well as decreased cesium pressures and increased TEC temperatures. Furthermore such thermal growth necessitates alloys that approach ultimate metal capabilities for space applications

  4. Equatorial Ionization Anomaly representation by TEC and foF2: A comparison between observational data and SUPIM simulation over Brazil

    Science.gov (United States)

    Nogueira, Paulo; Abdu, Mangalathayil Ali; Batista, Inez S.; Souza, Jonas

    The equatorial ionization anomaly (EIA) is studied using the Total Electron Content (TEC) of the ionosphere, measured by monitoring the Global Positioning System (GPS) satellites and F2 layer critical frequency (foF2), measured by digital ionosondes in the Brazilian region. In order to evaluate the strength and development of the equatorial anomaly, the following two parameters are used: ∆f oF 2 and ∆V T EC that represent the difference of foF2 and TEC, respectively, between the equatorial (EIA trough) and low latitude (EIA crest) sites. Significant differences in the EIA strength as represented by the two parameters and in its variations were observed, which motivated us to investigate these differences using model simulations. We have used the Sheffield University Plasmasphere Ionosphere Model (SUPIM) in this study, and the ionospheric data was obtained from digital ionosondes operated at São Lué (-2° 35', -44° 12'), a ıs ° ° ° ° Fortaleza (-3 52', -38 25') and Cachoeira Paulista (-22 41', -44 59') and from GPS receivers operated at São Lué and São José dos Campos (-23,18; 314,12), in Brazil. The comparisons a ıs a are performed for different solar flux conditions.

  5. A New Model for Real-Time Regional Vertical Total Electron Content and Differential Code Bias Estimation Using IGS Real-Time Service (IGS-RTS) Products

    Science.gov (United States)

    Abdelazeem, Mohamed; Çelik, Rahmi N.; El-Rabbany, Ahmed

    2016-04-01

    The international global navigation satellite system (GNSS) real-time service (IGS-RTS) products have been used extensively for real-time precise point positioning and ionosphere modeling applications. In this study, we develop a regional model for real-time vertical total electron content (RT-VTEC) and differential code bias (RT-DCB) estimation over Europe using the IGS-RTS satellite orbit and clock products. The developed model has a spatial and temporal resolution of 1°×1° and 15 minutes, respectively. GPS observations from a regional network consisting of 60 IGS and EUREF reference stations are processed in the zero-difference mode using the Bernese-5.2 software package in order to extract the geometry-free linear combination of the smoothed code observations. The spherical harmonic expansion function is used to model the VTEC, the receiver and the satellite DCBs. To validate the proposed model, the RT-VTEC values are computed and compared with the final IGS-global ionospheric map (IGS-GIM) counterparts in three successive days under high solar activity including one of an extreme geomagnetic activity. The real-time satellite DCBs are also estimated and compared with the IGS-GIM counterparts. Moreover, the real-time receiver DCB for six IGS stations are obtained and compared with the IGS-GIM counterparts. The examined stations are located in different latitudes with different receiver types. The findings reveal that the estimated RT-VTEC values show agreement with the IGS-GIM counterparts with root mean-square-errors (RMSEs) values less than 2 TEC units. In addition, RMSEs of both the satellites and receivers DCBs are less than 0.85 ns and 0.65 ns, respectively in comparison with the IGS-GIM.

  6. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF.

    Science.gov (United States)

    Li, Feifei; Jiang, Yinan; Zheng, Qiping; Yang, Xiaoming; Wang, Siying

    2011-01-07

    TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration. This study aims to investigate the putative mechanisms of TEC kinase regulation of hepatocyte differentiation, i.e. to explore which signaling pathway TEC is involved in, and how TEC is activated in hepatocyte after hepatectomy and hepatocyte growth factor (HGF) stimulation. We performed immunoprecipitation (IP) and immunoblotting (IB) to examine TEC tyrosine phosphorylation after partial hepatectomy in mice and HGF stimulation in WB F-344 hepatic cells. The TEC kinase activity was determined by in vitro kinase assay. Reporter gene assay, antisense oligonucleotide and TEC dominant negative mutant (TEC(KM)) were used to examine the possible signaling pathways in which TEC is involved. The cell proliferation rate was evaluated by (3)H-TdR incorporation. TEC phosphorylation and kinase activity were increased in 1 h after hepatectomy or HGF treatment. TEC enhanced the activity of Elk and serum response element (SRE). Inhibition of MEK1 suppressed TEC phosphorylation. Blocking TEC activity dramatically decreased the activation of Erk. Reduced TEC kinase activity also suppressed the proliferation of WB F-344 cells. These results suggest TEC is involved in the Ras-MAPK pathway and acts between MEK1 and Erk. TEC promotes hepatocyte proliferation and regeneration and is involved in HGF-induced Erk signaling pathway. Copyright © 2010 Elsevier Inc. All rights reserved.

  7. Regional 4-D modeling of the ionospheric electron density

    Science.gov (United States)

    Schmidt, M.; Bilitza, D.; Shum, C. K.; Zeilhofer, C.

    2008-08-01

    The knowledge of the electron density is the key point in correcting ionospheric delays of electromagnetic measurements and in studying the ionosphere. During the last decade GNSS, in particular GPS, has become a promising tool for monitoring the total electron content (TEC), i.e., the integral of the electron density along the ray-path between the transmitting satellite and the receiver. Hence, geometry-free GNSS measurements provide informations on the electron density, which is basically a four-dimensional function depending on spatial position and time. In addition, these GNSS measurements can be combined with other available data including nadir, over-ocean TEC observations from dual-frequency radar altimetry (T/P, JASON, ENVISAT), and TECs from GPS-LEO occultation systems (e.g., FORMOSAT-3/COSMIC, CHAMP) with heterogeneous sampling and accuracy. In this paper, we present different multi-dimensional approaches for modeling spatio-temporal variations of the ionospheric electron density. To be more specific, we split the target function into a reference part, computed from the International Reference Ionosphere (IRI), and an unknown correction term. Due to the localizing feature of B-spline functions we apply tensor-product spline expansions to model the correction term in a certain multi-dimensional region either completely or partly. Furthermore, the multi-resolution representation derived from wavelet analysis allows monitoring the ionosphere at different resolutions levels. For demonstration we apply three approaches to electron density data over South America.

  8. Plasma heating by high-energy-content microsecond electron beam at the GOL-3-II facility

    International Nuclear Information System (INIS)

    Agafonov, M.A.; Arzhannikov, A.V.; Astrelin, V.T.

    1996-01-01

    A description of the GOL-3-II facility and the first experimental results obtained on this new device are presented. This facility was constructed as part of the second stage of the GOL-3 programme for studying the interaction of microsecond electron beams with a plasma and its fast heating. The plasma column of the GOL-3-II facility is 12 m in length instead of 7 m for the first stage of GOL-3. The energy content of the capacity storage for magnetic field supply has been increased from 10 MJ to 15 MJ. This allows us to have a magnetic field of up to 5 T in the homogeneous part of the solenoid and up to 10 T in its end mirrors. The expected key feature of the upgrading is an essential increase in the energy content of the electron beam injected into the plasma. The high-power electron beam generator U-2 is now used for the new beam-plasma interaction experiments with possible beam energy content of up to 0.3 MJ. It is shown experimentally that transportation of a 0.2 MJ electron beam through the 12 m plasma column is possible under conditions of almost full current neutralization. The collective beam-plasma interaction results in a plasma heting of up to 1-2 keV electron temperature at ∼ 10 15 cm -3 density. (author)

  9. Electronic Dictionary as a Tool for Integration of Additional Learning Content

    Directory of Open Access Journals (Sweden)

    Stefka Kovacheva

    2015-12-01

    Full Text Available Electronic Dictionary as a Tool for Integration of Additional Learning Content This article discusses electronic dictionary as an element of the „Bulgarian cultural and historical heritage under the protection of UNESCO” database developed in IMI (BAS, that will be used to integrate additional learning content. The electronic dictionary is described as an easily accessible book of reference, offering information to the shape, meaning, usage and the origin of words in connection to the cultural-historical heritage sites in Bulgaria, protected by UNESCO. The dictionary targets 9–11 year old students from Bulgarian schools, who study the subjects “Man and Society” in 4th grade and “History and Civilization” in 5th grade.

  10. Local TEC Modelling and Forecasting using Neural Networks

    Science.gov (United States)

    Tebabal, A.; Radicella, S. M.; Nigussie, M.; Damtie, B.; Nava, B.; Yizengaw, E.

    2017-12-01

    Abstract Modelling the Earth's ionospheric characteristics is the focal task for the ionospheric community to mitigate its effect on the radio communication, satellite navigation and technologies. However, several aspects of modelling are still challenging, for example, the storm time characteristics. This paper presents modelling efforts of TEC taking into account solar and geomagnetic activity, time of the day and day of the year using neural networks (NNs) modelling technique. The NNs have been designed with GPS-TEC measured data from low and mid-latitude GPS stations. The training was conducted using the data obtained for the period from 2011 to 2014. The model prediction accuracy was evaluated using data of year 2015. The model results show that diurnal and seasonal trend of the GPS-TEC is well reproduced by the model for the two stations. The seasonal characteristics of GPS-TEC is compared with NN and NeQuick 2 models prediction when the latter one is driven by the monthly average value of solar flux. It is found that NN model performs better than the corresponding NeQuick 2 model for low latitude region. For the mid-latitude both NN and NeQuick 2 models reproduce the average characteristics of TEC variability quite successfully. An attempt of one day ahead forecast of TEC at the two locations has been made by introducing as driver previous day solar flux and geomagnetic index values. The results show that a reasonable day ahead forecast of local TEC can be achieved.

  11. 78 FR 64207 - Application To Export Electric Energy; TEC Energy Inc.

    Science.gov (United States)

    2013-10-28

    ... DEPARTMENT OF ENERGY [OE Docket No. EA-388] Application To Export Electric Energy; TEC Energy Inc.... SUMMARY: TEC Energy Inc. (TEC) has applied for authority to transmit electric energy from the United... received an application from TEC for authority to transmit electric energy from the United States to Canada...

  12. The role of Tec family kinases in the regulation of T-helper-cell differentiation.

    Science.gov (United States)

    Boucheron, Nicole; Ellmeier, Wilfried

    2012-04-01

    ABSTRACT Members of the Tec kinase family (Tec, Btk, Itk, Rlk, and Bmx) play an important role during innate and adaptive immune responses, and mutations in Tec family kinases are linked with immunodeficiencies in humans and mice. Three members of the Tec kinase family are expressed in T cells (Tec, Itk, and Rlk), and biochemical and genetic studies have revealed important roles for Tec family kinases during T-cell development and in the control of T-cell function. Here the authors review the role of Tec family kinases in the regulation of T-helper-cell differentiation.

  13. Contents

    Directory of Open Access Journals (Sweden)

    Editor IJRED

    2012-11-01

    Full Text Available International Journal of Renewable Energy Development www.ijred.com Volume 1             Number 3            October 2012                ISSN 2252- 4940   CONTENTS OF ARTICLES page Design and Economic Analysis of a Photovoltaic System: A Case Study 65-73 C.O.C. Oko , E.O. Diemuodeke, N.F. Omunakwe, and E. Nnamdi     Development of Formaldehyde Adsorption using Modified Activated Carbon – A Review 75-80 W.D.P Rengga , M. Sudibandriyo and M. Nasikin     Process Optimization for Ethyl Ester Production in Fixed Bed Reactor Using Calcium Oxide Impregnated Palm Shell Activated Carbon (CaO/PSAC 81-86 A. Buasri , B. Ksapabutr, M. Panapoy and N. Chaiyut     Wind Resource Assessment in Abadan Airport in Iran 87-97 Mojtaba Nedaei       The Energy Processing by Power Electronics and its Impact on Power Quality 99-105 J. E. Rocha and B. W. D. C. Sanchez       First Aspect of Conventional Power System Assessment for High Wind Power Plants Penetration 107-113 A. Merzic , M. Music, and M. Rascic   Experimental Study on the Production of Karanja Oil Methyl Ester and Its Effect on Diesel Engine 115-122 N. Shrivastava,  , S.N. Varma and M. Pandey  

  14. Effects of Crab Cavities' Multipole Content in an Electron-Ion Collider

    Energy Technology Data Exchange (ETDEWEB)

    Satogata, Todd J. [Jefferson Lab., Newport News, VA (United States); Morozov, Vasiliy [Jefferson Lab., Newport News, VA (United States); Delayen, Jean R. [Old Dominion Univ., Norfolk, VA (United States); Jefferson Lab., Newport News, VA (United States); Castillo, Alejandro [Old Dominion Univ., Norfolk, VA (United States)

    2015-09-01

    The impact on the beam dynamics of the Medium Energy Electron-Ion Colider (MEIC) due to the multipole content of the 750 MHz crab cavity was studied using thin multipole elements for 6D phase space particle tracking in ELEGANT. Target values of the sextupole component for the cavity’s field expansion were used to perform preliminary studies on the proton beam stability when compared to the case of pure dipole content of the rf kicks. Finally, important effects on the beam sizes due to non-linear components of the crab cavities’ fields were identified, and some criteria for their future study were proposed.

  15. Japan Link Center (JaLC): link management and DOI assignment for Japanese electronic scholarly contents

    Science.gov (United States)

    Kato, Takafumi; Tsuchiya, Eri; Kubota, Soichi; Miyagawa, Yoshiyuki

    JST, cooperated with several national institutes, is currently developing “Japan Link Center”, which manages Japanese electronic scholarly contents (journal articles, books, dissertations etc.) in an integrated fashion using Digital Object Identifier (DOI). Japan Link Center will manage metadata and whereabouts information of the contents in the digital environment and provide domestic and international linking information, cite/cited information to activate dissemination of S&T information, furthermore, to strengthen transmission of S&T information from Japan. Japan Link Center is expected to be appointed as the 9th DOI registration agency (RA) in the world by the International DOI Foundation (IDF) this spring.

  16. Preliminary study of TEC application in cooling system

    Science.gov (United States)

    Sulaiman, A. C.; Amin, N. A. M.; Saidon, M. S.; Majid, M. S. A.; Rahman, M. T. A.; Kazim, M. N. F. M.

    2017-10-01

    Integration of thermoelectric cooling (TEC) within a space cooling system in the lecturer room is studied. The studied area (air conditioned surrounding) is encapsulated with wall, floor, roof, and glass window. TEC module is placed on the glass window. The prototype of the studied compartment is designed using cabin container. The type and number of TEC module are studied and the effects on the cooling performance are analyzed as it is assumed to be tested within an air conditioned lecturer room. The experimental and mathematical modeling of the cooling system developed. It is expected that the mathematical modeling derived from this study will be used to estimate the use of the number of TEC module to be integrated with air conditioner unit where possible.

  17. Effect of electron radiation on sugar content in inverted liquid sugar

    International Nuclear Information System (INIS)

    Podadera, P.; Sabato, S.F.

    2009-01-01

    Inverted liquid sugar is a mixture of sucrose, glucose and fructose, which shows its relevant characteristic on high sweetness power. Ionizing radiation has been applied to different kind of food and ingredients for different reasons, such as pathogens reduction, disinfestations, quarantine purposes, ripening delay among others. Radiation from an electron beam can be utilized as a technique to treat this ingredient because it can process a great volume of material per unit of time. The main goal of this paper was to verify the effect of radiation on the properties of inverted liquid sugar. This ingredient was irradiated in an electron accelerator (Radiation Dynamics) at a dose ranging from 5 to 50 kGy. Sucrose content measurements were reduced by 23% at 30 kGy when compared to control and the reduced sugar content increased around 11%. Density and moisture values were not affected by radiation. The total soluble solids (Brix degrees) rose in function of the absorbed dose. (authors)

  18. First Results from the GPS Compact Total Electron Content Sensor (CTECS) on the PSSC2 Nanosat

    Science.gov (United States)

    Bishop, R. L.; Straus, P. R.; Hinkley, D.; Brubaker, T. R.

    2011-12-01

    The Compact Total Electron Content Sensor (CTECS) is a GPS radio occultation instrument designed for cubesat platforms that utilizes a COTS receiver, modified firmware, and a custom designed antenna. CTECS was placed on the Pico Satellite Solar Cell Testbed 2 (PSSC2) nanosat that was installed on the Space Shuttle Atlantis (STS-135). PSSC2 was successfully released from the shuttle on 20 July 2011. After approximately 2-4 weeks of spacecraft checkout and attitude adjustments, CTECS will be powered on and begin its mission to obtain ionospheric measurements of the total electron content and scintillation. This presentation describes the CTECS instrument, presents ground test data, initial on-orbit data, as well as future flight opportunities.

  19. Thermo-ecological cost (TEC evaluation of metallurgical processes

    Directory of Open Access Journals (Sweden)

    W. Stanek

    2015-01-01

    Full Text Available Metallurgy represents a complex production system of fuel and mineral non-renewable resources transformation. The effectiveness of resource management in metallurgical chains depends on the applied ore grade and on the irreversibility of components of the system. TEC can be applied to measure the influence of metallurgy on the depletion of natural resources. The paper discusses the possibility of application of TEC in metallurgy and presents illustrative example concerning blast-furnace process.

  20. Identification of an allosteric signaling network within Tec family kinases.

    Science.gov (United States)

    Joseph, Raji E; Xie, Qian; Andreotti, Amy H

    2010-10-22

    The Tec family kinases are tyrosine kinases that function primarily in hematopoietic cells. The catalytic activity of the Tec kinases is positively influenced by the regulatory domains outside of the kinase domain. The current lack of a full-length Tec kinase structure leaves a void in our understanding of how these positive regulatory signals are transmitted to the kinase domain. Recently, a conserved structure within kinases, the 'regulatory spine', which assembles and disassembles as a kinase switches between its active and inactive states, has been identified. Here, we define the residues that comprise the regulatory spine within Tec kinases. Compared to previously characterized systems, the Tec kinases contain an extended regulatory spine that includes a conserved methionine within the C-helix and a conserved tryptophan within the Src homology 2-kinase linker of Tec kinases. This extended regulatory spine forms a conduit for transmitting the presence of the regulatory domains of Tec kinases to the catalytic domain. We further show that mutation of the gatekeeper residue at the edge of the regulatory spine stabilizes the regulatory spine, resulting in a constitutively active kinase domain. Importantly, the regulatory spine is preassembled in this gatekeeper mutant, rendering phosphorylation on the activation loop unnecessary for its activity. Moreover, we show that the disruption of the conserved electrostatic interaction between Bruton's tyrosine kinase R544 on the activation loop and Bruton's tyrosine kinase E445 on the C-helix also aids in the assembly of the regulatory spine. Thus, the extended regulatory spine is a key structure that is critical for maintaining the activity of Tec kinases. Copyright © 2010 Elsevier Ltd. All rights reserved.

  1. Determinations of ionosphere and plasmasphere electron content for an African chain of GPS stations

    OpenAIRE

    A. J. Mazzella Jr.; J. B. Habarulema; E. Yizengaw

    2017-01-01

    The confluence of recent instrumentation deployments in Africa with developments for the determination of plasmasphere electron content using Global Positioning System (GPS) receivers has provided new opportunities for investigations in that region. This investigation, using a selected chain of GPS stations, extends the method (SCORPION) previously applied to a chain of GPS stations in North America in order to separate the ionosphere and plasmasphere contributions to the to...

  2. Ionospheric electron content within the equatorial F2 layer anomaly belt

    International Nuclear Information System (INIS)

    Rastogi, R.G.; Klobuchar, J.A.

    1990-01-01

    This paper describes some new results on the day-to-day behavior of the location of the equatorial anomaly in the columnar electron content. The measurements were made from a unique network of stations covering dip latitudes from 0 degree N to 25 degree N during the period in 1975-1976 near sunspot minimum when the ATS 67 satellite was visible from India. The latitudinal distribution of the total electron content on a particular day was found to depend only on the strength of the electrojet current, as determined by the difference of the horizontal magnetic field at stations on the magnetic equator and another outside the equatorial electrojet, rather than on the horizontal magnetic field measured only at the equatorial station. During magnetically disturbed periods the presence or absence of the anomaly was also found to depend only upon the strength of the electrojet current. The varying electrojet current, that is, the equatorial electric field, is very effective in moving the ionization to the anomaly latitudes of 15 degree-20 degree, but the columnar electron content over the magnetic equator remains relatively constant

  3. The role of Tec family kinases in mononuclear phagocytes.

    Science.gov (United States)

    Koprulu, Afitap Derya; Ellmeier, Wilfried

    2009-01-01

    Mononuclear phagocytes, including monocytcs, macrophages, and dendritic cells, play an important role in innate and adaptive immune responses and are important regulators of the inflammatory response. Among these, monocytes/macrophages are involved in virtually all aspects of inflammation, ranging from the detection and phagocytosis of pathogens up to the resolution of inflammation and repair of tissue damage. The stimulation of cell surface receptors, such as Toll-like receptors, leads to the initiation of intracellular signal transduction pathways regulating macrophagc activation and effector functions. One group of signaling molecules stimulated on macrophage activation is formed by the Tec kinasc family, which consists of five members (Bmx, Btk, Itk, Rlk, and Tec) and constitutes the second-largest family of nonreceptor protein tyrosine kinases in the immune system. Some Tec kinases have been shown to be major regulators of antigen receptor signaling in lymphocytes, and deficiencies in Tec family kinases cause several immunological defects in humans and mice. Much less is known about the role of Tec family kinases in the myeloid branch of the hematopoietic system. In this review, we discuss the current knowledge about the role of Tec family kinases in monocytes/macrophages, in dendritic cells, and in osteoclasts.

  4. Comparing electronic probes for volumetric water content of low-density feathermoss

    Science.gov (United States)

    Overduin, P.P.; Yoshikawa, K.; Kane, D.L.; Harden, J.W.

    2005-01-01

    Purpose - Feathermoss is ubiquitous in the boreal forest and across various land-cover types of the arctic and subarctic. A variety of affordable commercial sensors for soil moisture content measurement have recently become available and are in use in such regions, often in conjunction with fire-susceptibility or ecological studies. Few come supplied with calibrations suitable or suggested for soils high in organics. Aims to test seven of these sensors for use in feathermoss, seeking calibrations between sensor output and volumetric water content. Design/methodology/approach - Measurements from seven sensors installed in live, dead and burned feathermoss samples, drying in a controlled manner, were compared to moisture content measurements. Empirical calibrations of sensor output to water content were determined. Findings - Almost all of the sensors tested were suitable for measuring the moss sample water content, and a unique calibration for each sensor for this material is presented. Differences in sensor design lead to changes in sensitivity as a function of volumetric water content, affecting the spatial averaging over the soil measurement volume. Research limitations/implications - The wide range of electromagnetic sensors available include frequency and time domain designs with variations in wave guide and sensor geometry, the location of sensor electronics and operating frequency. Practical implications - This study provides information for extending the use of electromagnetic sensors to feathermoss. Originality/value - A comparison of volumetric water content sensor mechanics and design is of general interest to researchers measuring soil water content. In particular, researchers working in wetlands, boreal forests and tundra regions will be able to apply these results. ?? Emerald Group Publishing Limited.

  5. Plasma bubble monitoring by TEC map and 630 nm airglow image

    Science.gov (United States)

    Takahashi, H.; Wrasse, C. M.; Otsuka, Y.; Ivo, A.; Gomes, V.; Paulino, I.; Medeiros, A. F.; Denardini, C. M.; Sant'Anna, N.; Shiokawa, K.

    2015-08-01

    Equatorial ionosphere plasma bubbles over the South American continent were successfully observed by mapping the total electron content (TECMAP) using data provided by ground-based GNSS receiver networks. The TECMAP could cover almost all of the continent within ~4000 km distance in longitude and latitude, monitoring TEC variability continuously with a time resolution of 10 min. Simultaneous observations of OI 630 nm all-sky image at Cachoeira Paulista (22.7°S, 45.0°W) and Cariri (7.4°S, 36.5°W) were used to compare the bubble structures. The spatial resolution of the TECMAP varied from 50 km to 1000 km, depending on the density of the observation sites. On the other hand, optical imaging has a spatial resolution better than 15 km, depicting the fine structure of the bubbles but covering a limited area (~1600 km diameter). TECMAP has an advantage in its spatial coverage and the continuous monitoring (day and night) form. The initial phase of plasma depletion in the post-sunset equatorial ionization anomaly (PS-EIA) trough region, followed by development of plasma bubbles in the crest region, could be monitored in a progressive way over the magnetic equator. In December 2013 to January 2014, periodically spaced bubble structures were frequently observed. The longitudinal spacing between the bubbles was around 600-800 km depending on the day. The periodic form of plasma bubbles may suggest a seeding process related to the solar terminator passage in the ionosphere.

  6. Content

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    Aim, content and methods are fundamental categories of both theoretical and practical general didactics. A quick glance in recent pedagogical literature on higher education, however, reveals a strong preoccupation with methods, i.e. how teaching should be organized socially (Biggs & Tang, 2007......, is subordinating content to methods as seen in modern didactics, hereby transforming content to a medium for achievement of learning-to-learn skills rather than something valuable in its own right. At the level of general didactics quite few attempts have been made to formulate criteria and categories...... secondary levels. In subject matter didactics, the question of content is more developed, but it is still mostly confined to teaching on lower levels. As for higher education didactics, discussions on selection of content are almost non-existent on the programmatic level. Nevertheless, teachers are forced...

  7. An Examination of Electronic Cigarette Content on Social Media: Analysis of E-Cigarette Flavor Content on Reddit

    Directory of Open Access Journals (Sweden)

    Lei Wang

    2015-11-01

    Full Text Available In recent years, the emerging electronic cigarette (e-cigarette marketplace has shown great development prospects all over the world. Reddit, one of the most popular forums in the world, has a very large user group and thus great influence. This study aims to gain a systematic understanding of e-cigarette flavors based on data collected from Reddit. Flavor popularity, mixing, characteristics, trends, and brands are analyzed. Fruit flavors were mentioned the most (n = 15,720 among all the posts and were among the most popular flavors (n = 2902 used in mixed blends. Strawberry and vanilla flavors were the most popular for e-juice mixing. The number of posts discussing e-cigarette flavors has increased sharply since 2014. Mt. Baker Vapor and Hangen were the most popular brands discussed among users. Information posted on Reddit about e-cigarette flavors reflected consumers’ interest in a variety of flavors. Our findings suggest that Reddit could be used for data mining and analysis of e-cigarette-related content. Understanding how e-cigarette consumers’ view and utilize flavors within their vaping experience and how producers and marketers use social media to promote flavors and sell products could provide valuable information for regulatory decision-makers.

  8. An Examination of Electronic Cigarette Content on Social Media: Analysis of E-Cigarette Flavor Content on Reddit.

    Science.gov (United States)

    Wang, Lei; Zhan, Yongcheng; Li, Qiudan; Zeng, Daniel D; Leischow, Scott J; Okamoto, Janet

    2015-11-20

    In recent years, the emerging electronic cigarette (e-cigarette) marketplace has shown great development prospects all over the world. Reddit, one of the most popular forums in the world, has a very large user group and thus great influence. This study aims to gain a systematic understanding of e-cigarette flavors based on data collected from Reddit. Flavor popularity, mixing, characteristics, trends, and brands are analyzed. Fruit flavors were mentioned the most (n = 15,720) among all the posts and were among the most popular flavors (n = 2902) used in mixed blends. Strawberry and vanilla flavors were the most popular for e-juice mixing. The number of posts discussing e-cigarette flavors has increased sharply since 2014. Mt. Baker Vapor and Hangen were the most popular brands discussed among users. Information posted on Reddit about e-cigarette flavors reflected consumers' interest in a variety of flavors. Our findings suggest that Reddit could be used for data mining and analysis of e-cigarette-related content. Understanding how e-cigarette consumers' view and utilize flavors within their vaping experience and how producers and marketers use social media to promote flavors and sell products could provide valuable information for regulatory decision-makers.

  9. An Examination of Electronic Cigarette Content on Social Media: Analysis of E-Cigarette Flavor Content on Reddit

    Science.gov (United States)

    Wang, Lei; Zhan, Yongcheng; Li, Qiudan; Zeng, Daniel D.; Leischow, Scott J.; Okamoto, Janet

    2015-01-01

    In recent years, the emerging electronic cigarette (e-cigarette) marketplace has shown great development prospects all over the world. Reddit, one of the most popular forums in the world, has a very large user group and thus great influence. This study aims to gain a systematic understanding of e-cigarette flavors based on data collected from Reddit. Flavor popularity, mixing, characteristics, trends, and brands are analyzed. Fruit flavors were mentioned the most (n = 15,720) among all the posts and were among the most popular flavors (n = 2902) used in mixed blends. Strawberry and vanilla flavors were the most popular for e-juice mixing. The number of posts discussing e-cigarette flavors has increased sharply since 2014. Mt. Baker Vapor and Hangen were the most popular brands discussed among users. Information posted on Reddit about e-cigarette flavors reflected consumers’ interest in a variety of flavors. Our findings suggest that Reddit could be used for data mining and analysis of e-cigarette-related content. Understanding how e-cigarette consumers’ view and utilize flavors within their vaping experience and how producers and marketers use social media to promote flavors and sell products could provide valuable information for regulatory decision-makers. PMID:26610541

  10. New methods of determination of the total electron content in the transverse zone

    International Nuclear Information System (INIS)

    Keroub, I.H.

    1976-01-01

    New methods for the determination of T.E.C. in the transverse zone are developed in the present study. The methods are mainly based on a rigorous calculation of the propagation of electromagnetic waves in an anisotropic geophysical plasma. The methods are described according to the recorded information (satellitic frequencies, universal time) involved in their utilization. Finally, it is show how to apply these methods to any station situated at a geomagnetic latitude comparable with that of Haifa by way of a suitable treatment of the available information

  11. Electron beam process for SO2 removal from flue gases with high SO2 content

    International Nuclear Information System (INIS)

    Licki, J.; Chmielewski, A.G.; Zimek, Z.; Tyminski, B.; Bulka, S.

    2002-01-01

    Flue gases with high SO 2 concentration are emitted from different industrial processes, e.g. combustion of coal with high sulfur content, copper smelting and sintering plant. The application of the electron beam process for SO 2 removal from such flue gases was investigated. A parametric study was carried out to determine the removal efficiency as a function of temperature and humidity of irradiated gases, dose and ammonia stoichiometry. At the dose 11.5 kGy 95% SO 2 removal efficiency was obtained when the temperature and humidity of irradiated flue gases and ammonia stoichiometry were properly adjusted. The synergistic effect of high SO 2 concentration on NO x removal was observed. The collected by-product was the mixture of (NH 4 ) 2 SO 4 and NH 4 NO 3 . The content of heavy metals in the by-product was many times lower than the values acceptable for commercial fertilizer

  12. Cryogenic electronics

    Energy Technology Data Exchange (ETDEWEB)

    Fourches, N.; Abbon, P.; Delagnes, E.; Le Meur, L.P.

    1995-04-01

    This study presents the cryogenic electronics, which is used in high energy physics with appropriate device. It discuss their ability to hardening against ionization radiation and neutrons. Some partial results on the operation of microelectronics devices at cryogenic temperature are given. (TEC). 33 refs., 13 figs.

  13. Spatial and time variations of the integral electron content in the outer ionosphere

    International Nuclear Information System (INIS)

    Solodovnikov, G.K.

    1983-01-01

    The data are presented on the space-time variations of the integral content of Nsub(OB) electrons in the outer ionosphere within one day at latitudes PHI >= 30 deg for summer and winter seasons under conditions of strong and weak solar activity. The data refer to the case of weak magnetic activity. A polynominal appproximation of NOB distributions is presented. The approximation suggested gives a rather correct description of the space-time Nsub(OB) distribution under quiet ionospheric conditions at PHI >=30 of the nothern hemisphere and can be useful in calculations of integral characteristics of radio wave propagation

  14. Beyond the electronic textbook model: software techniques to make on-line educational content dynamic.

    Science.gov (United States)

    Frank, M S; Dreyer, K

    2001-06-01

    We describe a working software technology that enables educators to incorporate their expertise and teaching style into highly interactive and Socratic educational material for distribution on the world wide web. A graphically oriented interactive authoring system was developed to enable the computer novice to create and store within a database his or her domain expertise in the form of electronic knowledge. The authoring system supports and facilitates the input and integration of several types of content, including free-form, stylized text, miniature and full-sized images, audio, and interactive questions with immediate feedback. The system enables the choreography and sequencing of these entities for display within a web page as well as the sequencing of entire web pages within a case-based or thematic presentation. Images or segments of text can be hyperlinked with point-and-click to other entities such as adjunctive web pages, audio, or other images, cases, or electronic chapters. Miniature (thumbnail) images are automatically linked to their full-sized counterparts. The authoring system contains a graphically oriented word processor, an image editor, and capabilities to automatically invoke and use external image-editing software such as Photoshop. The system works in both local area network (LAN) and internet-centric environments. An internal metalanguage (invisible to the author but stored with the content) was invented to represent the choreographic directives that specify the interactive delivery of the content on the world wide web. A database schema was developed to objectify and store both this electronic knowledge and its associated choreographic metalanguage. A database engine was combined with page-rendering algorithms in order to retrieve content from the database and deliver it on the web in a Socratic style, assess the recipient's current fund of knowledge, and provide immediate feedback, thus stimulating in-person interaction with a human expert

  15. Behavior Change Techniques Implemented in Electronic Lifestyle Activity Monitors: A Systematic Content Analysis

    Science.gov (United States)

    Lewis, Zakkoyya H; Mayrsohn, Brian G; Rowland, Jennifer L

    2014-01-01

    Background Electronic activity monitors (such as those manufactured by Fitbit, Jawbone, and Nike) improve on standard pedometers by providing automated feedback and interactive behavior change tools via mobile device or personal computer. These monitors are commercially popular and show promise for use in public health interventions. However, little is known about the content of their feedback applications and how individual monitors may differ from one another. Objective The purpose of this study was to describe the behavior change techniques implemented in commercially available electronic activity monitors. Methods Electronic activity monitors (N=13) were systematically identified and tested by 3 trained coders for at least 1 week each. All monitors measured lifestyle physical activity and provided feedback via an app (computer or mobile). Coding was based on a hierarchical list of 93 behavior change techniques. Further coding of potentially effective techniques and adherence to theory-based recommendations were based on findings from meta-analyses and meta-regressions in the research literature. Results All monitors provided tools for self-monitoring, feedback, and environmental change by definition. The next most prevalent techniques (13 out of 13 monitors) were goal-setting and emphasizing discrepancy between current and goal behavior. Review of behavioral goals, social support, social comparison, prompts/cues, rewards, and a focus on past success were found in more than half of the systems. The monitors included a range of 5-10 of 14 total techniques identified from the research literature as potentially effective. Most of the monitors included goal-setting, self-monitoring, and feedback content that closely matched recommendations from social cognitive theory. Conclusions Electronic activity monitors contain a wide range of behavior change techniques typically used in clinical behavioral interventions. Thus, the monitors may represent a medium by which

  16. Evaluation of Wet Digestion Methods for Quantification of Metal Content in Electronic Scrap Material

    Directory of Open Access Journals (Sweden)

    Subhabrata Das

    2017-11-01

    Full Text Available Recent advances in the electronics sector and the short life-span of electronic products have triggered an exponential increase in the generation of electronic waste (E-waste. Effective recycling of E-waste has thus become a serious solid waste management challenge. E-waste management technologies include pyrometallurgy, hydrometallurgy, and bioleaching. Determining the metal content of an E-waste sample is critical in evaluating the efficiency of a metal recovery method in E-waste recycling. However, E-waste is complex and of diverse origins. The lack of a standard digestion method for E-waste has resulted in difficulty in comparing the efficiencies of different metal recovery processes. In this study, several solid digestion protocols including American Society for Testing and Materials (ASTM-D6357-11, United States Environment Protection Agency Solid Waste (US EPA SW 846 Method 3050b, ultrasound-assisted, and microwave digestion methods were compared to determine the metal content (Ag, Al, Au, Cu, Fe, Ni, Pb, Pd, Sn, and Zn of electronic scrap materials (ESM obtained from two different sources. The highest metal recovery (mg/g of ESM was obtained using ASTM D6357-11 for most of the metals, which remained mainly bound to silicate fractions, while a microwave-assisted digestion protocol (MWD-2 was more effective in solubilizing Al, Pb, and Sn. The study highlights the need for a judicious selection of digestion protocol, and proposes steps for selecting an effective acid digestion method for ESM.

  17. Evaluating the performance of the Electron Density Assimilative Model (EDAM) in the Western European sector using modified Taylor diagrams

    Science.gov (United States)

    Jackson-Booth, N.; Parker, J.; Pryse, S. E.; Buckland, R.

    2017-12-01

    The Electron Density Assimilative Model (EDAM) is an ionospheric model that assimilates data sources into a background model, currently provided by IRI2007, to generate a global, or regional, 3D representation of the ionospheric electron density. In this study, slant total electron content (sTEC) between GPS satellites and 43 ground receivers in Europe were assimilated into EDAM to model the ionospheric electron density over western Europe. For the evaluation of the model an additional ground receiver (the truth station) was considered, which was not used in the assimilation process. Slant total electron contents for this station were calculated through the EDAM model along satellite-to-receiver paths corresponding to those of the observations made by the receiver. The modelled and observed sTEC were compared for each satellite and every day, between September 2002 and August 2003. For the comparison standard deviations of the modelled and observed sTEC were determined. These were used in modified Taylor Diagrams to display the mean-removed rms difference between the model and observations, the correlation between the two data sets and the bias of the modelled data. Taylor diagrams were obtained for the entire year, and each season and month. Results of the comparisons are presented and discussed, with a specific interest in times that show increased rms differences and decreased correlations between the data sets. The effect of the satellite calibration biases on the results are also considered.

  18. Total electron content measurements at Gauhati using 140 MHz ATS-6 transmissions

    International Nuclear Information System (INIS)

    Tyagi, T.R.; Singh, L.; Minakshi Devi; Barbara, A.K.

    1977-01-01

    The amplitude and phase of 140 MHz transmissions from geostationary satellite ATS-6 (0 0 N, 35 0 E) have been recorded at Gauhati (26.16 0 N; 91.75 0 E) for the period Nov. 1975 to Aug. 1976. The calibration technique for geostationary satellite Faraday rotation measurements suggested by Checcacci and Giorgeo has been improved and generalized. It is then utilized to remove the n ambiguity in Faraday rotation values and also to estimate the correct value of diurnal minimum Faraday rotation angle so that the recorded Faraday rotation values can be converted into electron content values. Typical diurnal variation curves have been obtained for all the months except for equinoxes when the satellite transmission was off very often due to ecliptic conditions and hence no complete diurnal curves could be obtained for these months. It has been found that though December and January behave like typical winter months, the month of November is more like an equinoctial month. Similarly, though June and July behave like typical summer months, the month of May is more or less similar to equinoxes. The characteristic features of the diurnal and seasonal behaviour of the electron content have been discussed. (author)

  19. In this issue: Tec kinases in the crosshairs.

    Science.gov (United States)

    Faris, Mary; Bot, Adrian

    2012-04-01

    Tec family kinases are the second largest family of non-receptor tyrosine kinases, of critical importance to the biology of cells derived from the bone marrow. Significant progress in this area during the last decade revealed a role for several of these kinases in inflammatory and oncologic disorders. This led to the discovery and development of molecular targeted therapies against Tec kinases, most notably to date Btk, already showing promising clinical activity in B cell lymphoma and autoimmunity. As Btk does not carry oncogenic modifications, this also establishes a novel therapeutic paradigm, based on targeting ancillary pathways recruited by the pathogenic process to become pivotal to cancer cell's biology. This issue focuses on biology and translation of Tec kinases, at the cross-roads between immunology and cancer.

  20. A picture is worth a thousand words: Electronic cigarette content on Instagram and Pinterest

    Science.gov (United States)

    Lee, Alexander S.; Hart, Joy L.; Sears, Clara G.; Walker, Kandi L.; Siu, Allison; Smith, Courteney

    2017-01-01

    INTRODUCTION This study examined electronic cigarette (e-cig) content in visual materials posted on the social-media platforms Instagram and Pinterest. Both platforms allow users to upload pictures to the internet and share them globally. Users can search for pictures tagged with specific keywords and phrases. METHODS Using content analysis, this study identified themes in image postings of e-cigs on social media. During five weeks of data collection, keywords were used to identify pictures related to e-cigs. These pictures were then coded into one or more categories. RESULTS The three most popular categories for Instagram posts were marketing, customization and juices/flavors. The three most popular categories for Pinterest posts were customization, marketing and memes. CONCLUSIONS Because of the persuasive power of visuals, it is important to examine communication on Instagram and Pinterest as well as the specific visual messages communicated. Stores and manufacturers use these and similar platforms to communicate with users and potential users; thus it seems that marketers are capitalizing on opportunities for persuasive appeal. The results highlight the popularity of e-cig content on these two social media platforms and reveal an emphasis on marketing and customization. PMID:28815224

  1. A picture is worth a thousand words: Electronic cigarette content on Instagram and Pinterest.

    Science.gov (United States)

    Lee, Alexander S; Hart, Joy L; Sears, Clara G; Walker, Kandi L; Siu, Allison; Smith, Courteney

    2017-07-01

    This study examined electronic cigarette (e-cig) content in visual materials posted on the social-media platforms Instagram and Pinterest. Both platforms allow users to upload pictures to the internet and share them globally. Users can search for pictures tagged with specific keywords and phrases. Using content analysis, this study identified themes in image postings of e-cigs on social media. During five weeks of data collection, keywords were used to identify pictures related to e-cigs. These pictures were then coded into one or more categories. The three most popular categories for Instagram posts were marketing, customization and juices/flavors. The three most popular categories for Pinterest posts were customization, marketing and memes. Because of the persuasive power of visuals, it is important to examine communication on Instagram and Pinterest as well as the specific visual messages communicated. Stores and manufacturers use these and similar platforms to communicate with users and potential users; thus it seems that marketers are capitalizing on opportunities for persuasive appeal. The results highlight the popularity of e-cig content on these two social media platforms and reveal an emphasis on marketing and customization.

  2. Mathematical modelling of ionospheric TEC from Turkish permanent GNSS Network (TPGN) observables during 2009-2017 and predictability of NeQuick and Kriging models

    Science.gov (United States)

    Ansari, Kutubuddin; Panda, Sampad Kumar; Corumluoglu, Ozsen

    2018-03-01

    The present study examines the ionospheric Total Electron Content (TEC) variations in the lower mid-latitude Turkish region from the Turkish permanent GNSS network (TPGN) and International GNSS Services (IGS) observations during the years 2009 to 2017. The corresponding vertical TEC (VTEC) predicted by Kriging and NeQuick-2 models are evaluated to realize their efficacy over the country. We studied the diurnal, seasonal and spatial pattern of VTEC variation and tried to estimate by a new mathematical model using the long term of 9 years VTEC data. The diurnal variation of VTEC demonstrates a normal trend with its gradual enhancement from dawn to attain a peak around 09:00-14.00 UT and reaching the minimum level after 22.00 UT. The seasonal behavior of VTEC indicates a strong semi-annual variation of VTEC with maxima in September equinox followed by March equinox and minima in June solstice followed by December solstice. Also, the spatial variation in VTEC depicts a meaningful longitudinal/latitudinal pattern altering with seasons. It decreases longitudinally from the west to the east during March equinox and June solstice increases with latitude. The comparative analysis among the GNSS-VTEC, Kriging, NeQuick and the proposed mathematical model are evaluated with the help one way ANOVA test. The analysis shows that the null hypothesis of the models during storm and quiet days are accepted and suggesting that all models are statistically significantly equivalent from each other. We believe the outcomes from this study would complement towards a relatively better understanding of the lower mid-latitude VTEC variation over the Turkish region and analogous latitudes over the globe.

  3. The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.

    Science.gov (United States)

    Kim, Sol; Lee, Hye Jin; Jun, Hee Jung; Kim, Jungho

    2008-06-01

    Human extraskeletal myxoid chondrosarcoma (EMC) is caused by a chromosomal translocation that involves TEC (translocated in extraskeletal myxoid chondrosarcoma), and either EWS (Ewing's sarcoma) or hTAF(II)68 (human TATA-binding protein-associated factor II 68), which generates EWS-TEC or hTAF(II)68-TEC fusion proteins, respectively. Although there has been a great deal of progress in characterizing EWS-TEC, there is relatively little known about the biological function of hTAF(II)68-TEC. We have examined the functional consequences of the fusion of the amino terminal domain (NTD) of hTAF(II)68 to TEC in EMC. The chimeric gene encodes a nuclear protein that binds DNA with the same sequence specificity as parental TEC. Nuclear localization of hTAF(II)68-TEC was dependent on the DNA binding domain, and we identified a cluster of basic amino acids in the DNA binding domain, KRRR, that specifically mediate the nuclear localization of hTAF(II)68-TEC. The transactivation activity of hTAF(II)68-TEC was higher than TEC towards a known target promoter that contained several TEC binding sites. Finally, deletion analysis of hTAF(II)68-TEC indicated that the hTAF(II)68 NTD, and the AF1 and AF2 domains of hTAF(II)68-TEC are necessary for full transactivation potential. These results suggest that the oncogenic effect of the t(9;17) translocation may be due to the hTAF(II)68-TEC chimeric protein and that fusion of the hTAF(II)68 NTD to the TEC protein produces a gain of function chimeric product. (c) 2008 Wiley-Liss, Inc.

  4. BioElectronic Tongue for the quantification of total polyphenol content in wine.

    Science.gov (United States)

    Cetó, Xavier; Céspedes, Francisco; del Valle, Manel

    2012-09-15

    This work reports the application of a BioElectronic Tongue (BioET) in the estimation of polyphenol content in wine. The approach used an array of enzyme biosensors capable of giving a wide and complete response of the analyzed species, plus a chemometric processing tool able to interpret the chemical signals and extract meaningful data from the complex readings. In our case, the proposed BioET was formed by an array of four voltammetric enzymatic biosensors based on epoxy-graphite composites, one blank electrode and the other three bulk-modified with tyrosinase and laccase on one side, and copper nanoparticles on the other; these modifiers were used in order to incorporate differentiated or catalytic response to different polyphenols present in wine and aimed to the determination of its total polyphenol content value. The obtained voltammetric responses were pre-processed employing the Fast Fourier Transform (FFT); this was used to compress the relevant information whereas the obtained coefficients fed an Artificial Neural Network (ANN) model that accomplished the quantification of total polyphenol content. For comparison purposes, obtained polyphenol content was compared against the one assessed by two different reference methods: Folin-Ciocalteu and UV polyphenol index (I(280)); good prediction ability was attained with correlation coefficients higher than 0.949 when comparing against reference methods. Qualitative discrimination of individual polyphenols found in wine was also assessed by means of Principal Component Analysis which allowed the discrimination of the individual polyphenols under study. Copyright © 2012 Elsevier B.V. All rights reserved.

  5. Comparison of GPS derived TEC with the TEC predicted by IRI 2012 model in the southern Equatorial Ionization Anomaly crest within the Eastern Africa region

    Science.gov (United States)

    Sulungu, Emmanuel D.; Uiso, Christian B. S.; Sibanda, Patrick

    2018-04-01

    We have compared the TEC obtained from the IRI-2012 model with the GPS derived TEC data recorded within southern crest of the EIA in the Eastern Africa region using the monthly means of the 5 international quiet days for equinoxes and solstices months for the period of 2012 - 2013. GPS-derived TEC data have been obtained from the Africa array and IGS network of ground based dual-frequency GPS receivers from four stations (Kigali (1.95°S, 30.09°E; Geom. Lat. 11.63°S), Malindi (2.99°S, 40.19°E; Geom. Lat. 12.42°S), Mbarara (0.60°S, 30.74°E; Geom. Lat. 10.22°S) and Nairobi (1.22°S, 36.89°E; Geom. Lat. 10.69°S)) located within the EIA crest in this region. All the three options for topside Ne of IRI-2012 model and ABT-2009 for bottomside thickness have been used to compute the IRI TEC. Also URSI coefficients were considered in this study. These results are compared with the TEC estimated from GPS measurements. Correlation Coefficients between the two sets of data, the Root-Mean Square Errors (RMSE) of the IRI-TEC from the GPS-TEC, and the percentage RMSE of the IRI-TEC from the GPS-TEC have been computed. Our general results show that IRI-2012 model with all three options overestimates the GPS-TEC for all seasons and at all stations, and IRI-2001 overestimates GPS-TEC more compared with other options. IRI-Neq and IRI-01-corr are closely matching in most of the time. The observation also shows that, GPS TEC are underestimated by TEC from IRI model during noon hours, especially during equinoctial months. Further, GPS-TEC values and IRI-TEC values using all the three topside Ne options show very good correlation (above 0.8). On the other hand, the TEC using IRI-Neq and IRI-01- corr had smaller deviations from the GPS-TEC compared to the IRI-2001.

  6. Low carbon content NiTi shape memory alloy produced by electron beam melting

    Directory of Open Access Journals (Sweden)

    Otubo Jorge

    2004-01-01

    Full Text Available Earlier works showed that the use of electron beam melting is a viable process to produce NiTi shape memory alloy. In those works a static and a semi-dynamic processes were used producing small shell-shaped and cylindrical ingots respectively. The main characteristics of those samples were low carbon concentration and good composition homogeneity throughout the samples. This paper presents the results of scaling up the ingot size and processing procedure using continuous charge feeding and continuous casting. The composition homogeneity was very good demonstrated by small variation in martensitic transformation temperatures with carbon content around 0.013wt% compared to 0.04 to 0.06wt% of commercial products.

  7. TecCOMFrame : A competence framework for technical communication

    NARCIS (Netherlands)

    Cleary, Yvonne; Karreman, Joyce; Closs, Sissi; Drazek, Zygmunt; Engberg, Jan; Ghenghea, Voichita; Meex, Birgitta; Minacori, Patricia; Muller, J.; Straub, Daniela

    2017-01-01

    The role of technical communicators is expanding due to technology. However, many individuals throughout Europe gain employment as technical communicators without undergoing specialized training. TecCOMFrame, a three-year project funded by the European Union, aims to develop: 1) a common academic

  8. C-TEC: Ohio's First All-Green School

    Science.gov (United States)

    Krall, Angie

    2009-01-01

    In Ohio's Licking County, the Career and Technology Education Centers (C-TEC) is a leader in the green movement. This eco-friendly school incorporates environmental sustainability in all aspects of its programming and is the first Leadership in Energy and Environmental Design (LEED)-certified public building in the state. While eco-friendly…

  9. Why do people use electronic nicotine delivery systems (electronic cigarettes)? A content analysis of Twitter, 2012-2015

    Science.gov (United States)

    Ayers, John W.; Leas, Eric C.; Allem, Jon-Patrick; Benton, Adrian; Dredze, Mark; Althouse, Benjamin M.; Cruz, Tess B.; Unger, Jennifer B.

    2017-01-01

    The reasons for using electronic nicotine delivery systems (ENDS) are poorly understood and are primarily documented by expensive cross-sectional surveys that use preconceived close-ended response options rather than allowing respondents to use their own words. We passively identify the reasons for using ENDS longitudinally from a content analysis of public postings on Twitter. All English language public tweets including several ENDS terms (e.g., “e-cigarette” or “vape”) were captured from the Twitter data stream during 2012 and 2015. After excluding spam, advertisements, and retweets, posts indicating a rationale for vaping were retained. The specific reasons for vaping were then inferred based on a supervised content analysis using annotators from Amazon’s Mechanical Turk. During 2012 quitting combustibles was the most cited reason for using ENDS with 43% (95%CI 39–48) of all reason-related tweets cited quitting combustibles, e.g., “I couldn’t quit till I tried ecigs,” eclipsing the second most cited reason by more than double. Other frequently cited reasons in 2012 included ENDS’s social image (21%; 95%CI 18–25), use indoors (14%; 95%CI 11–17), flavors (14%; 95%CI 11–17), safety relative to combustibles (9%; 95%CI 7–11), cost (3%; 95%CI 2–5) and favorable odor (2%; 95%CI 1–3). By 2015 the reasons for using ENDS cited on Twitter had shifted. Both quitting combustibles and use indoors significantly declined in mentions to 29% (95%CI 24–33) and 12% (95%CI 9–16), respectively. At the same time, social image increased to 37% (95%CI 32–43) and lack of odor increased to 5% (95%CI 2–5), the former leading all cited reasons in 2015. Our data suggest the reasons people vape are shifting away from cessation and toward social image. The data also show how the ENDS market is responsive to a changing policy landscape. For instance, smoking indoors was less frequently cited in 2015 as indoor smoking restrictions became more common

  10. Why do people use electronic nicotine delivery systems (electronic cigarettes)? A content analysis of Twitter, 2012-2015.

    Science.gov (United States)

    Ayers, John W; Leas, Eric C; Allem, Jon-Patrick; Benton, Adrian; Dredze, Mark; Althouse, Benjamin M; Cruz, Tess B; Unger, Jennifer B

    2017-01-01

    The reasons for using electronic nicotine delivery systems (ENDS) are poorly understood and are primarily documented by expensive cross-sectional surveys that use preconceived close-ended response options rather than allowing respondents to use their own words. We passively identify the reasons for using ENDS longitudinally from a content analysis of public postings on Twitter. All English language public tweets including several ENDS terms (e.g., "e-cigarette" or "vape") were captured from the Twitter data stream during 2012 and 2015. After excluding spam, advertisements, and retweets, posts indicating a rationale for vaping were retained. The specific reasons for vaping were then inferred based on a supervised content analysis using annotators from Amazon's Mechanical Turk. During 2012 quitting combustibles was the most cited reason for using ENDS with 43% (95%CI 39-48) of all reason-related tweets cited quitting combustibles, e.g., "I couldn't quit till I tried ecigs," eclipsing the second most cited reason by more than double. Other frequently cited reasons in 2012 included ENDS's social image (21%; 95%CI 18-25), use indoors (14%; 95%CI 11-17), flavors (14%; 95%CI 11-17), safety relative to combustibles (9%; 95%CI 7-11), cost (3%; 95%CI 2-5) and favorable odor (2%; 95%CI 1-3). By 2015 the reasons for using ENDS cited on Twitter had shifted. Both quitting combustibles and use indoors significantly declined in mentions to 29% (95%CI 24-33) and 12% (95%CI 9-16), respectively. At the same time, social image increased to 37% (95%CI 32-43) and lack of odor increased to 5% (95%CI 2-5), the former leading all cited reasons in 2015. Our data suggest the reasons people vape are shifting away from cessation and toward social image. The data also show how the ENDS market is responsive to a changing policy landscape. For instance, smoking indoors was less frequently cited in 2015 as indoor smoking restrictions became more common. Because the data and analytic approach are

  11. Consumers’ Preferences for Electronic Nicotine Delivery System Product Features: A Structured Content Analysis

    Directory of Open Access Journals (Sweden)

    Christine E. Kistler

    2017-06-01

    Full Text Available To inform potential governmental regulations, we aimed to develop a list of electronic nicotine delivery system (ENDS product features important to U.S. consumers by age and gender. We employed qualitative data methods. Participants were eligible if they had used an ENDS at least once. Groups were selected by age and gender (young adult group aged 18–25, n = 11; middle-age group aged 26–64, n = 9; and women’s group aged 26–64, n = 9. We conducted five individual older adult interviews (aged 68–80. Participants discussed important ENDS features. We conducted a structured content analysis of the group and interview responses. Of 34 participants, 68% were white and 56% were female. Participants mentioned 12 important ENDS features, including: (1 user experience; (2 social acceptability; (3 cost; (4 health risks/benefits; (5 ease of use; (6 flavors; (7 smoking cessation aid; (8 nicotine content; (9 modifiability; (10 ENDS regulation; (11 bridge between tobacco cigarettes; (12 collectability. The most frequently mentioned ENDS feature was modifiability for young adults, user experience for middle-age and older adults, and flavor for the women’s group. This study identified multiple features important to ENDS consumers. Groups differed in how they viewed various features by age and gender. These results can inform ongoing regulatory efforts.

  12. A novel protein tyrosine kinase Tec identified in lamprey, Lampetra japonica.

    Science.gov (United States)

    Li, Ranran; Su, Peng; Liu, Chang; Zhang, Qiong; Zhu, Ting; Pang, Yue; Liu, Xin; Li, Qingwei

    2015-08-01

    Protein tyrosine kinase Tec, a kind of non-receptor tyrosine kinase, is primarily found to be expressed in T cells, B cells, hematopoietic cells, and liver cells as a cytoplasmic protein. Tec has been proved to be a critical modulator of T cell receptor signaling pathway. In the present study, a homolog of Tec was identified in the lamprey, Lampetra japonica. The full-length Tec cDNA of L. japonica (Lja-Tec) contains a 1923 bp open reading frame that encodes a 641-amino acid protein. The multi-alignment of the deduced amino acid sequence of Lja-Tec with typical vertebrate Tecs showed that it possesses all conserved domains of the Tec family proteins, indicating that an ortholog of Tec exists in the extant jawless vertebrate. In the phylogenetic tree that was reconstructed with 24 homologs of jawless and jawed vertebrates, the Tecs from lampreys and hagfish were clustered as a single clade. The genetic distance between the outgroup and agnathan Tecs' group is closer than that between outgroup and gnathostome Tecs' group, indicating that its origin was far earlier than any of the jawed vertebrates. The mRNA levels of Lja-Tec in lymphocyte-like cells and gills were detected by real-time quantitative polymerase chain reaction. Results showed that it was significantly upregulated under stimulation with mixed pathogens. This result was further confirmed by western blot analysis. All these results indicated that Lja-Tec plays an important role in immune response. Our data will provide a reference for the further study of lamprey Tec and its immunological function in jawless vertebrates. © The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

  13. The TFG-TEC fusion gene created by the t(3;9) translocation in human extraskeletal myxoid chondrosarcomas encodes a more potent transcriptional activator than TEC.

    Science.gov (United States)

    Lim, Bobae; Jun, Hee Jung; Kim, Ah-young; Kim, Sol; Choi, JeeHyun; Kim, Jungho

    2012-08-01

    The t(3;9)(q11-q12;q22) translocation associated with human extraskeletal myxoid chondrosarcomas results in a chimeric molecule in which the N-terminal domain (NTD) of the TFG (TRK-fused gene) is fused to the TEC (Translocated in Extraskeletal Chondrosarcoma) gene. Little is known about the biological function of TFG-TEC. Because the NTDs of TFG-TEC and TEC are structurally different, and the TFG itself is a cytoplasmic protein, the functional consequences of this fusion in extraskeletal myxoid chondrosarcomas were examined. The results showed that the chimeric gene encoded a nuclear protein that bound DNA with the same sequence specificity as the parental TEC protein. Comparison of the transactivation properties of TFG-TEC and TEC indicated that the former has higher transactivation activity for a known target reporter containing TEC-binding sites. Additional reporter assays for TFG (NTD) showed that the TGF (NTD) of TFG-TEC induced a 12-fold increase in the activation of luciferase from a reporter plasmid containing GAL4 binding sites when fused to the DNA-binding domain of GAL4, indicating that the TFG (NTD) of the TFG-TEC protein has intrinsic transcriptional activation properties. Finally, deletion analysis of the functional domains of TFG (NTD) indicated that the PB1 (Phox and Bem1p) and SPYGQ-rich region of TFG (NTD) were capable of activating transcription and that full integrity of TFG (NTD) was necessary for full transactivation. These results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC chimeric protein and that fusion of the TFG (NTD) to the TEC protein produces a gain-of-function chimeric product.

  14. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.

    Science.gov (United States)

    Melcher, Martin; Unger, Bernd; Schmidt, Uwe; Rajantie, Iiro A; Alitalo, Kari; Ellmeier, Wilfried

    2008-06-15

    Tec family kinases have important roles in lymphocytes; however, little is known about their function in monocytes/macrophages. In this study we report that Tec family kinases are essential for M-CSF (M-CSF)-induced signaling pathways that regulate macrophage survival. Compared with wild-type bone marrow-derived macrophage (BMM) cultures, Tec(-/-)Btk(-/-) BMM cultures displayed increased cell death that correlated with a severe drop in macrophage numbers. In addition, macrophages deficient in either Tec or Btk showed expression and activation of caspase-11. Elucidation of M-CSF receptor (M-CSFR) signaling pathways revealed that the total tyrosine phosphorylation pattern upon M-CSF stimulation was altered in Tec(-/-)Btk(-/-) macrophages despite normal expression and phosphorylation of the M-CSFR. Further, Tec and Btk are required for proper expression of the GM-CSF receptor alpha (GM-CSFRalpha) chain in macrophages but not dendritic cells, implicating Tec family kinases in the lineage-specific regulation of GM-CSFRalpha expression. Taken together, our study shows that Tec and Btk regulate M-CSFR signaling-induced macrophage survival and provides a novel link between Tec family kinases and the regulation of caspase-11 and GM-CSFRalpha expression.

  15. A TFG-TEC nuclear localization mutant forms complexes with the wild-type TFG-TEC oncoprotein and suppresses its activity.

    Science.gov (United States)

    Lim, Bobae; Kim, Ah-young; Jun, Hee Jung; Kim, Jungho

    2013-12-15

    Human EMCs (extraskeletal myxoid chondrosarcomas) are soft tissue tumours characterized by specific chromosomal abnormalities. Recently, a proportion of EMCs were found to harbour a characteristic translocation, t(3;9)(q11-12;q22), involving the TFG (TRK-fused gene) at 3q11-12 and the TEC (translocated in extraskeletal chondrosarcoma) gene at 9q22. The present study used both in vitro and in vivo systems to show that the TFG-TEC protein self-associates, and that this is dependent upon the CC (coiled-coil) domain (amino acids 97-124), the AF1 (activation function 1) domain (amino acids 275-562) and the DBD (DNA-binding domain) (amino acids 563-655). The TFG-TEC protein also associated with a mutant NLS-TFG-TEC (AAAA) protein, which harbours mutations in the NLS (nuclear localization signal). Subcellular localization assays showed that the NLS mutant TFG-TEC (AAAA) protein interfered with the nuclear localization of wild-type TFG-TEC. Most importantly, the mutant protein inhibited TFG-TEC-mediated transcriptional activation in vivo. Thus mutations in the TFG-TEC NLS yield a dominant-negative protein. These results show that the biological functions of the TFG-TEC oncogene can be modulated by a dominant-negative mutant.

  16. Tec protein tyrosine kinase inhibits CD25 expression in human T-lymphocyte.

    Science.gov (United States)

    Susaki, Kentaro; Kitanaka, Akira; Dobashi, Hiroaki; Kubota, Yoshitsugu; Kittaka, Katsuharu; Kameda, Tomohiro; Yamaoka, Genji; Mano, Hiroyuki; Mihara, Keichiro; Ishida, Toshihiko

    2010-01-04

    The Tec protein tyrosine kinase (PTK) belongs to a group of structurally related nonreceptor PTKs that also includes Btk, Itk, Rlk, and Bmx. Previous studies have suggested that these kinases play important roles in hematopoiesis and in the lymphocyte signaling pathway. Despite evidence suggesting the involvement of Tec in the T-lymphocyte activation pathway via T-cell receptor (TCR) and CD28, Tec's role in T-lymphocytes remains unclear because of the lack of apparent defects in T-lymphocyte function in Tec-deficient mice. In this study, we investigated the role of Tec in human T-lymphocyte using the Jurkat T-lymphoid cell line stably transfected with a cDNA encoding Tec. We found that the expression of wild-type Tec inhibited the expression of CD25 induced by TCR cross-linking. Second, we observed that LFM-A13, a selective inhibitor of Tec family PTK, rescued the suppression of TCR-induced CD25 expression observed in wild-type Tec-expressing Jurkat cells. In addition, expression of kinase-deleted Tec did not alter the expression level of CD25 after TCR ligation. We conclude that Tec PTK mediates signals that negatively regulate CD25 expression induced by TCR cross-linking. This, in turn, implies that this PTK plays a role in the attenuation of IL-2 activity in human T-lymphocytes.

  17. Content analysis of physical examination templates in electronic health records using SNOMED CT.

    Science.gov (United States)

    Gøeg, Kirstine Rosenbeck; Chen, Rong; Højen, Anne Randorff; Elberg, Pia

    2014-10-01

    Most electronic health record (EHR) systems are built on proprietary information models and terminology, which makes achieving semantic interoperability a challenge. Solving interoperability problems requires well-defined standards. In contrast, the need to support clinical work practice requires a local customization of EHR systems. Consequently, contrasting goals may be evident in EHR template design because customization means that local EHR organizations can define their own templates, whereas standardization implies consensus at some level. To explore the complexity of balancing these two goals, this study analyzes the differences and similarities between templates in use today. A similarity analysis was developed on the basis of SNOMED CT. The analysis was performed on four physical examination templates from Denmark and Sweden. The semantic relationships in SNOMED CT were used to quantify similarities and differences. Moreover, the analysis used these identified similarities to investigate the common content of a physical examination template. The analysis showed that there were both similarities and differences in physical examination templates, and the size of the templates varied from 18 to 49 fields. In the SNOMED CT analysis, exact matches and terminology similarities were represented in all template pairs. The number of exact matches ranged from 7 to 24. Moreover, the number of unrelated fields differed a lot from 1/18 to 22/35. Cross-country comparisons tended to have more unrelated content than within-country comparisons. On the basis of identified similarities, it was possible to define the common content of a physical examination. Nevertheless, a complete view on the physical examination required the inclusion of both exact matches and terminology similarities. This study revealed that a core set of items representing the physical examination templates can be generated when the analysis takes into account not only exact matches but also terminology

  18. Assessing Electronic Cigarette-Related Tweets for Sentiment and Content Using Supervised Machine Learning

    Science.gov (United States)

    Cole-Lewis, Heather; Varghese, Arun; Sanders, Amy; Schwarz, Mary; Pugatch, Jillian

    2015-01-01

    Background Electronic cigarettes (e-cigarettes) continue to be a growing topic among social media users, especially on Twitter. The ability to analyze conversations about e-cigarettes in real-time can provide important insight into trends in the public’s knowledge, attitudes, and beliefs surrounding e-cigarettes, and subsequently guide public health interventions. Objective Our aim was to establish a supervised machine learning algorithm to build predictive classification models that assess Twitter data for a range of factors related to e-cigarettes. Methods Manual content analysis was conducted for 17,098 tweets. These tweets were coded for five categories: e-cigarette relevance, sentiment, user description, genre, and theme. Machine learning classification models were then built for each of these five categories, and word groupings (n-grams) were used to define the feature space for each classifier. Results Predictive performance scores for classification models indicated that the models correctly labeled the tweets with the appropriate variables between 68.40% and 99.34% of the time, and the percentage of maximum possible improvement over a random baseline that was achieved by the classification models ranged from 41.59% to 80.62%. Classifiers with the highest performance scores that also achieved the highest percentage of the maximum possible improvement over a random baseline were Policy/Government (performance: 0.94; % improvement: 80.62%), Relevance (performance: 0.94; % improvement: 75.26%), Ad or Promotion (performance: 0.89; % improvement: 72.69%), and Marketing (performance: 0.91; % improvement: 72.56%). The most appropriate word-grouping unit (n-gram) was 1 for the majority of classifiers. Performance continued to marginally increase with the size of the training dataset of manually annotated data, but eventually leveled off. Even at low dataset sizes of 4000 observations, performance characteristics were fairly sound. Conclusions Social media outlets

  19. Assessing Electronic Cigarette-Related Tweets for Sentiment and Content Using Supervised Machine Learning.

    Science.gov (United States)

    Cole-Lewis, Heather; Varghese, Arun; Sanders, Amy; Schwarz, Mary; Pugatch, Jillian; Augustson, Erik

    2015-08-25

    Electronic cigarettes (e-cigarettes) continue to be a growing topic among social media users, especially on Twitter. The ability to analyze conversations about e-cigarettes in real-time can provide important insight into trends in the public's knowledge, attitudes, and beliefs surrounding e-cigarettes, and subsequently guide public health interventions. Our aim was to establish a supervised machine learning algorithm to build predictive classification models that assess Twitter data for a range of factors related to e-cigarettes. Manual content analysis was conducted for 17,098 tweets. These tweets were coded for five categories: e-cigarette relevance, sentiment, user description, genre, and theme. Machine learning classification models were then built for each of these five categories, and word groupings (n-grams) were used to define the feature space for each classifier. Predictive performance scores for classification models indicated that the models correctly labeled the tweets with the appropriate variables between 68.40% and 99.34% of the time, and the percentage of maximum possible improvement over a random baseline that was achieved by the classification models ranged from 41.59% to 80.62%. Classifiers with the highest performance scores that also achieved the highest percentage of the maximum possible improvement over a random baseline were Policy/Government (performance: 0.94; % improvement: 80.62%), Relevance (performance: 0.94; % improvement: 75.26%), Ad or Promotion (performance: 0.89; % improvement: 72.69%), and Marketing (performance: 0.91; % improvement: 72.56%). The most appropriate word-grouping unit (n-gram) was 1 for the majority of classifiers. Performance continued to marginally increase with the size of the training dataset of manually annotated data, but eventually leveled off. Even at low dataset sizes of 4000 observations, performance characteristics were fairly sound. Social media outlets like Twitter can uncover real-time snapshots of

  20. The TolTEC Camera for the LMT Telescope

    Science.gov (United States)

    Bryan, Sean

    2018-01-01

    TolTEC is a new camera being built for the 50-meter Large Millimeter-wave Telescope (LMT) on Sierra Negra in Puebla, Mexico. The instrument will discover and characterize distant galaxies by detecting the thermal emission of dust heated by starlight. The polarimetric capabilities of the camera will measure magnetic fields in star-forming regions in the Milky Way. The optical design of the camera uses mirrors, lenses, and dichroics to simultaneously couple a 4 arcminute diameter field of view onto three single-band focal planes at 150, 220, and 280 GHz. The 7000 polarization-selective detectors are single-band horn-coupled LEKID detectors fabricated at NIST. A rotating half wave plate operates at ambient temperature to modulate the polarized signal. In addition to the galactic and extragalactic surveys already planned, TolTEC installed at the LMT will provide open observing time to the community.

  1. Association Analysis of TEC Polymorphisms with Aspirin-Exacerbated Respiratory Disease in a Korean Population.

    Science.gov (United States)

    Lee, Jin Sol; Bae, Joon Seol; Park, Byung-Lae; Cheong, Hyun Sub; Kim, Jeong-Hyun; Kim, Jason Yongha; Namgoong, Suhg; Kim, Ji-On; Park, Choon-Sik; Shin, Hyoung Doo

    2014-06-01

    The tyrosine-protein kinase Tec (TEC) is a member of non-receptor tyrosine kinases and has critical roles in cell signaling transmission, calcium mobilization, gene expression, and transformation. TEC is also involved in various immune responses, such as mast cell activation. Therefore, we hypothesized that TEC polymorphisms might be involved in aspirin-exacerbated respiratory disease (AERD) pathogenesis. We genotyped 38 TEC single nucleotide polymorphisms in a total of 592 subjects, which comprised 163 AERD cases and 429 aspirin-tolerant asthma controls. Logistic regression analysis was performed to examine the associations between TEC polymorphisms and the risk of AERD in a Korean population. The results revealed that TEC polymorphisms and major haplotypes were not associated with the risk of AERD. In another regression analysis for the fall rate of forced expiratory volume in 1 second (FEV1) by aspirin provocation, two variations (rs7664091 and rs12500534) and one haplotype (TEC_BL2_ht4) showed nominal associations with FEV1 decline (p = 0.03-0.04). However, the association signals were not retained after performing corrections for multiple testing. Despite TEC playing an important role in immune responses, the results from the present study suggest that TEC polymorphisms do not affect AERD susceptibility. Findings from the present study might contribute to the genetic etiology of AERD pathogenesis.

  2. Linking the content to demographic reach of online advertising of electronic nicotine delivery systems.

    Science.gov (United States)

    Timberlake, David S; Nikitin, Dmitriy; Garcia-Cano, Jennifer; Cino, Samantha; Savkina, Margarita; Pechmann, Cornelia

    2017-06-20

    Recent studies have separately examined the content and demographic reach of the advertising of electronic nicotine delivery systems (ENDS). No study to our knowledge has linked the two in investigating whether racial/ethnic groups are differentially exposed to the comparative messages conveyed in online ENDS advertisements. 932 unique ENDS advertisements (6311 total), which were posted on 3435 websites between December, 2009 and October, 2015, were categorized as either comparative or non-comparative with respect to the traditional cigarette. The race/ethnicity of website visitors was obtained from a proprietary source and used in constructing variables for racial/ethnic viewership. The variables for advertising content and website racial/ethnic viewership were then linked yielding a final sample of 551 unique ENDS advertisements (2498 total) on 1206 websites. A two-level hierarchical generalized linear model, used in estimating website racial/ethnic viewership as a predictor of comparative advertising, accounted for the nesting of advertisements (level 1) within 152 ENDS brands (level 2). In contrast to racial/ethnic minorities, a greater proportion of non-Hispanic whites visited websites with ENDS advertisements than the overall proportion of nonHispanic white U.S. Internet users. Yet, it was the advertisements on websites that appealed to Hispanics that had greater odds of comparing ENDS to traditional cigarettes. The lower exposure to ENDS advertising among racial/ethnic minorities versus non-Hispanic whites is consistent with survey data. Yet, the greater odds of comparative advertising of ENDS on websites that appeal to racial/ethnic minorities (ie, Hispanics) could impact the longterm health of minority smokers. This study's findings have important implications for the uptake of ENDS among minority smokers. If the comparative advertising yields greater interest and eventual use of ENDS, then minority smokers could either benefit from smoking cessation

  3. Integration of the End Cap TEC+ of the CMS Silicon Strip Tracker

    CERN Document Server

    Adler, Volker; Ageron, Michel; Agram, Jean-Laurent; Atz, Bernd; Barvich, Tobias; Baulieu, Guillaume; Beaumont, Willem; Beissel, Franz; Bergauer, Thomas; Berst, Jean-Daniel; Blüm, Peter; Bock, E; Bogelsbacher, F; de Boer, Wim; Bonnet, Jean-Luc; Bonnevaux, Alain; Boudoul, Gaelle; Bouhali, Othmane; Braunschweig, Wolfgang; Bremer, R; Brom, Jean-Marie; Butz, Erik; Chabanat, Eric; Chabert, Eric Christian; Clerbaux, Barbara; Contardo, Didier; De Callatay, Bernard; Dehm, Philip; Delaere, Christophe; Della Negra, Rodolphe; Dewulf, Jean-Paul; D'Hondt, Jorgen; Didierjean, Francois; Dierlamm, Alexander; Dirkes, Guido; Dragicevic, Marko; Drouhin, Frédéric; Ernenwein, Jean-Pierre; Esser, Hans; Estre, Nicolas; Fahrer, Manuel; Feld, Lutz; Fernández, J; Florins, Benoit; Flossdorf, Alexander; Flucke, Gero; Flügge, Günter; Fontaine, Jean-Charles; Freudenreich, Klaus; Frey, Martin; Friedl, Markus; Furgeri, Alexander; Giraud, Noël; Goerlach, Ulrich; Goorens, Robert; Graehling, Philippe; Grégoire, Ghislain; Gregoriev, E; Gross, Laurent; Hansel, S; Haroutunian, Roger; Hartmann, Frank; Heier, Stefan; Hermanns, Thomas; Heydhausen, Dirk; Heyninck, Jan; Hosselet, J; Hrubec, Josef; Jahn, Dieter; Juillot, Pierre; Kaminski, Jochen; Karpinski, Waclaw; Kaussen, Gordon; Keutgen, Thomas; Klanner, Robert; Klein, Katja; König, Stefan; Kosbow, M; Krammer, Manfred; Ledermann, Bernhard; Lemaître, Vincent; De Lentdecker, Gilles; Linn, Alexander; Lounis, Abdenour; Lübelsmeyer, Klaus; Lumb, Nicholas; Maazouzi, Chaker; Mahmoud, Tariq; Michotte, Daniel; Militaru, Otilia; Mirabito, Laurent; Müller, Thomas; Neukermans, Lionel; Ollivetto, C; Olzem, Jan; Ostapchuk, Andrey; Pandoulas, Demetrios; Pein, Uwe; Pernicka, Manfred; Perriès, Stephane; Piaseki, C; Pierschel, Gerhard; Piotrzkowski, Krzysztof; Poettgens, Michael; Pooth, Oliver; Rouby, Xavier; Sabellek, Andreas; Schael, Stefan; Schirm, Norbert; Schleper, Peter; Schmitz, Stefan Antonius; Schultz von Dratzig, Arndt; Siedling, Rolf; Simonis, Hans-Jürgen; Stahl, Achim; Steck, Pia; Steinbruck, G; Stoye, Markus; Strub, Roger; Tavernier, Stefaan; Teyssier, Daniel; Theel, Andreas; Trocmé, Benjamin; Udo, Fred; Van der Donckt, M; Van der Velde, C; Van Hove, Pierre; Vanlaer, Pascal; Van Lancker, Luc; Van Staa, Rolf; Vanzetto, Sylvain; Weber, Markus; Weiler, Thomas; Weseler, Siegfried; Wickens, John; Wittmer, Bruno; Wlochal, Michael; De Wolf, Eddi A; Zhukov, Valery; Zoeller, Marc Henning

    2009-01-01

    The silicon strip tracker of the CMS experiment has been completed and inserted into the CMS detector in late 2007. The largest sub-system of the tracker is its end cap system, comprising two large end caps (TEC) each containing 3200 silicon strip modules. To ease construction, the end caps feature a modular design: groups of about 20 silicon modules are placed on sub-assemblies called petals and these self-contained elements are then mounted into the TEC support structures. Each end cap consists of 144 petals, and the insertion of these petals into the end cap structure is referred to as TEC integration. The two end caps were integrated independently in Aachen (TEC+) and at CERN (TEC--). This note deals with the integration of TEC+, describing procedures for end cap integration and for quality control during testing of integrated sections of the end cap and presenting results from the testing.

  4. Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling.

    Science.gov (United States)

    de Bruijn, Marjolein J W; Rip, Jasper; van der Ploeg, Esmee K; van Greuningen, Lars W; Ta, Van T B; Kil, Laurens P; Langerak, Anton W; Rimmelzwaan, Guus F; Ellmeier, Wilfried; Hendriks, Rudi W; Corneth, Odilia B J

    2017-04-15

    The Tec tyrosine kinase is expressed in many cell types, including hematopoietic cells, and is a member of the Tec kinase family that also includes Btk. Although the role of Btk in B cells has been extensively studied, the role of Tec kinase in B cells remains largely unclear. It was previously shown that Tec kinase has the ability to partly compensate for loss of Btk activity in B cell differentiation, although the underlying mechanism is unknown. In this study, we confirm that Tec kinase is not essential for normal B cell development when Btk is present, but we also found that Tec-deficient mature B cells showed increased activation, proliferation, and survival upon BCR stimulation, even in the presence of Btk. Whereas Tec deficiency did not affect phosphorylation of phospholipase Cγ or Ca 2+ influx, it was associated with significantly increased activation of the intracellular Akt/S6 kinase signaling pathway upon BCR and CD40 stimulation. The increased S6 kinase phosphorylation in Tec-deficient B cells was dependent on Btk kinase activity, as ibrutinib treatment restored pS6 to wild-type levels, although Btk protein and phosphorylation levels were comparable to controls. In Tec-deficient mice in vivo, B cell responses to model Ags and humoral immunity upon influenza infection were enhanced. Moreover, aged mice lacking Tec kinase developed a mild autoimmune phenotype. Taken together, these data indicate that in mature B cells, Tec and Btk may compete for activation of the Akt signaling pathway, whereby the activating capacity of Btk is limited by the presence of Tec kinase. Copyright © 2017 by The American Association of Immunologists, Inc.

  5. Estimating the contribution from different ionospheric regions to the TEC response to the solar flares using data from the international GPS network

    Directory of Open Access Journals (Sweden)

    L. A. Leonovich

    2002-12-01

    Full Text Available This paper proposes a new method for estimating the contribution from different ionospheric regions to the response of total electron content variations to the solar flare, based on data from the international network of two-frequency multichannel receivers of the navigation GPS system. The method uses the effect of partial "shadowing" of the atmosphere by the terrestrial globe. The study of the solar flare influence on the atmosphere uses GPS stations located near the boundary of the shadow on the ground in the nightside hemisphere. The beams between the satellite-borne transmitter and the receiver on the ground for these stations pass partially through the atmosphere lying in the region of total shadow, and partially through the illuminated atmosphere. The analysis of the ionospheric effect of a powerful solar flare of class X5.7/3B that was recorded on 14 July 2000 (10:24 UT, N22 W07 in quiet geomagnetic conditions (Dst = -10 nT has shown that about 75% of the TEC increase corresponds to the ionospheric region lying below 300 km and about 25% to regions lying above 300 km.Key words. Ionosphere (solar radiation and cosmic ray effects; instruments and techniques – Solar physics, astrophysics and astronomy (ultraviolet emissions

  6. Estimating the contribution from different ionospheric regions to the TEC response to the solar flares using data from the international GPS network

    Directory of Open Access Journals (Sweden)

    L. A. Leonovich

    Full Text Available This paper proposes a new method for estimating the contribution from different ionospheric regions to the response of total electron content variations to the solar flare, based on data from the international network of two-frequency multichannel receivers of the navigation GPS system. The method uses the effect of partial "shadowing" of the atmosphere by the terrestrial globe. The study of the solar flare influence on the atmosphere uses GPS stations located near the boundary of the shadow on the ground in the nightside hemisphere. The beams between the satellite-borne transmitter and the receiver on the ground for these stations pass partially through the atmosphere lying in the region of total shadow, and partially through the illuminated atmosphere. The analysis of the ionospheric effect of a powerful solar flare of class X5.7/3B that was recorded on 14 July 2000 (10:24 UT, N22 W07 in quiet geomagnetic conditions (Dst = -10 nT has shown that about 75% of the TEC increase corresponds to the ionospheric region lying below 300 km and about 25% to regions lying above 300 km.

    Key words. Ionosphere (solar radiation and cosmic ray effects; instruments and techniques – Solar physics, astrophysics and astronomy (ultraviolet emissions

  7. Use of scanning electron microscopy and microanalysis to determine chloride content of concrete and raw materials.

    Science.gov (United States)

    2013-02-01

    Standard sample sets of cement and mortar formulations with known levels of Cl as well as concrete samples subject to Cl diffusion were all prepared for and analyzed with scanning electron microscopy (SEM) and electron microprobe (EPMA). Using x-ray ...

  8. 45 CFR 170.205 - Content exchange standards and implementation specifications for exchanging electronic health...

    Science.gov (United States)

    2010-10-01

    ...) Patient summary record—(1) Standard. Health Level Seven Clinical Document Architecture (CDA) Release 2... specifications for exchanging electronic health information. 170.205 Section 170.205 Public Welfare DEPARTMENT OF... exchange standards and implementation specifications for exchanging electronic health information. The...

  9. The improved DGR analytical model of electron density height profile and total electron content in the ionosphere

    OpenAIRE

    Radicella, S. M.; Zhang, M. L.

    1995-01-01

    Tests of the analytical model of the electron density profile originally proposed by G, Di Giovanni and S.M. Radicella (DGR model) have shown the need to introduce improvements in order to obtain a model able to reproduce the ionosphere in a larger spectrum of geophysical and time conditions. The present paper reviews the steps toward such progress and presents the final formulation of the model. It gives also a brief re- view of tests of the improved model done by different authors.

  10. Comparisons of IRI global TEC maps with CODE GIMs

    CERN Document Server

    Coisson, P; Radicella, S M

    2002-01-01

    The Global Ionospheric Maps (GIM) produced at CODE are used in this work as experimental reference to evaluate the performance of IRI in predicting global vertical TEC during a period of high solar activity. The analysis has been done for the four seasons of year 2001, comparing monthly median GIMs for 12 different UTs. The attention is focused on the correct reproduction of large scale features like the equatorial anomaly or behavior at high latitudes, to understand where and under which conditions the IRI model could present unexpectable features.

  11. COSMIC TEC tomographic vertical density reconstructions of the topside ionosphere and plasmasphere: Differences between the American and African sectors

    Science.gov (United States)

    Sibanda, P.; Moldwin, M.; Zou, S.; Yizengaw, E. K.

    2011-12-01

    Global Positioning System (GPS) navigation measurements have become useful in observing the ionospheric spatial electron density distribution TEC from ground-based receivers are biased by the high density around the F2 peak and therefore it is difficult to extract information about the topside ionosphere and plasmasphere. GPS measurements onboard Low Earth Orbiting (LEO) satellites provide more detailed observations of the ionospheric electron density distribution from the orbit height of the LEO satellite to GPS orbit heights. We use GPS TEC measurements onboard COSMIC satellites to reconstruct the topside ionosphere and plasmasphere electron density distribution for both geomagnetically quiet and disturbed conditions during over-flights of the American and African mid-latitude regions by the COSMIC spacecraft using algebraic tomographic reconstruction technique (ART). The reconstructions provide more detailed information of the longitudinal and vertical spatial structure of topside ionosphere and plasmasphere during both geomagnetically quiet and disturbed conditions, and indicate the great potential of evaluating ionospheric models in the topside ionosphere/plasmasphere altitude range.

  12. Tracking viral particles in the intestinal contents of the American bullfrog, Lithobates catesbeianus, by Transmission Electron Microscopy

    OpenAIRE

    Antonucci,A.M.; Catroxo,M.H.; Hipolito,M.; Takemoto,R.M.; Melo,N.A.; França,F.M.; Teixeira,P.C.; Ferreira,C.M.

    2014-01-01

    Feces are an important viral agent elimination route for infected carrier animals and in aquatic organisms these pathogenic agents can very rapidly propagate due to the habitation environment. The objective of this work is to track viral particles in the intestinal contents of bullfrogs (Lithobates catesbeianus) from five commercial frog farms in the region of Vale do Paraíba, in the State of São Paulo, Brazil, using negative contrast transmission electron microscopy (TEM). The Coronaviridae,...

  13. Comparison between IRI-2012 and GPS-TEC observations over the western Black Sea

    Science.gov (United States)

    Inyurt, Samed; Yildirim, Omer; Mekik, Cetin

    2017-07-01

    The ionosphere is a dynamic layer which generally changes according to radiation emitted by the sun, the movement of the earth around the sun, and sunspot activity. Variations can generally be categorized as regular or irregular variations. Both types of variation have a huge effect on radio wave propagation. In this study, we have focused on the seasonal variation effect, which is one of the regular forms of variation in terms of the ionosphere. We examined the seasonal variation over the ZONG station in Turkey for the year 2014. Our analysis results and IRI-2012 present different ideas about ionospheric activity. According to our analysed results, the standard deviation reached a maximum value in April 2014. However, the maximum standard deviation obtained from IRI-2012 was seen in February 2014. Furthermore, it is clear that IRI-2012 underestimated the VTEC values when compared to our results for all the months analysed. The main source of difference between the two models is the IRI-2012 topside ionospheric representation. IRI-2012 VTEC has been produced as a result of the integration of an electron density profile within altitudinal limits of 60-2000 km. In other words, the main problem with regard to the IRI-2012 VTEC representation is not being situated in the plasmaspheric part of the ionosphere. Therefore we propose that the plasmaspheric part should be taken into account to calculate the correct TEC values in mid-latitude regions, and we note that IRI-2012 does not supply precise TEC values for use in ionospheric studies.

  14. Fusion of Potentiometric & Voltammetric Electronic Tongue for Classification of Black Tea Taste based on Theaflavins (TF) Content

    Science.gov (United States)

    Bhattacharyya, Nabarun; Legin, Andrey; Papieva, Irina; Sarkar, Subrata; Kirsanov, Dmitry; Kartsova, Anna; Ghosh, Arunangshu; Bandyopadhyay, Rajib

    2011-09-01

    Black tea is an extensively consumed beverage worldwide with an expanding market. The final quality of black tea depends upon number of chemical compounds present in the tea. Out of these compounds, theaflavins (TF), which is responsible for astringency in black tea, plays an important role in determining the final taste of the finished black tea. The present paper reports our effort to correlate the theaflavins contents with the voltammetric and potentiometric electronic tongue (e-tongue) data. Noble metal-based electrode array has been used for collecting data though voltammetric electronic tongue where as liquid filled membrane based electrodes have been used for potentiometric electronic tongue. Black tea samples with tea taster score and biochemical results have been collected from Tea Research Association, Tocklai, India for the analysis purpose. In this paper, voltammetric and potentiometric e-tongue responses are combined to demonstrate improvement of cluster formation among tea samples with different ranges of TF values.

  15. Charging process of polyurethane based composites under electronic irradiation: Effects of cellulose fiber content

    Science.gov (United States)

    Hadjadj, Aomar; Jbara, Omar; Tara, Ahmed; Gilliot, Mickael; Dellis, Jean-Luc

    2013-09-01

    The study deals with the charging effect of polyurethanes-based composites reinforced with cellulose fibers, under electronic beam irradiation in a scanning electron microscope. The results indicate that the leakage current and the trapped charge as well as the kinetics of charging process significantly change beyond a critical concentration of 10% cellulose fibers. These features are correlated with the cellulose concentration-dependence of the electrical properties, specifically resistivity and capacitance, of the composite.

  16. CONTENT MARKETING AND SUPPLIER SELECTION IN THE ELECTRONIC PAYMENT SERVICE INDUSTRY

    OpenAIRE

    Pennala, Eino

    2015-01-01

    Increasing e-commerce creates demand for electronic payment services to make online shopping as convenient as possible. Payment service providers (PSPs) publish whitepapers on their websites to provide information for e-commerce businesses in need of a PSP. This study has two major purposes: (1) to determine the criteria for e-commerce business when selecting a payment service provider, and (2) to investigate the role of whitepapers in supplier selection in the electronic payment service...

  17. Waddenfonds Tidal Texel Demonstration project. BlueTEC Texel Tidal Project: Environmental measurement and performance analysis

    NARCIS (Netherlands)

    Ponsoni, L.; Nauw, J.J.; Smit, M.; Ober, S.; Nichols, C.; Kenkhuis, J.; Schmidt, C.; Buatois, A.; de Haas, P.

    2016-01-01

    In the context of the BlueTEC project, this report starts by introducing theBlueTEC tidal energy platform and reviewing the patterns of circulation of theMarsdiep inlet. The energy resource assessment and the site selection for theplatform's deployment are reported. This document analyses di?erent

  18. NF-kappaB regulates the transcription of protein tyrosine kinase Tec.

    Science.gov (United States)

    Yu, Liang; Simonson, Oscar E; Mohamed, Abdalla J; Smith, C I Edvard

    2009-11-01

    The tyrosine kinase expressed in hepatocellular carcinoma (Tec) is a non-receptor protein tyrosine kinase (PTK) that is expressed in hematopoietic cells, such as B and T lymphocytes, myeloid lineage cells and neutrophils. Mutations in the human Btk gene cause X-linked agammaglobulinemia (XLA), but the corresponding mutation in mice results in a much milder defect. However, the combined inactivation of Btk and Tec genes in mice cause a severe phenotype resembling XLA. Tec is involved in the regulation of both B and T lymphocytes, fine-tuning of TCR/BCR signaling, and also activation of the nuclear factor of activated T cells. Previous work has shown that the transcription factors Sp1 and PU.1 can bind and regulate the Tec promoter. In this study, we demonstrate that NF-kappaB is an essential transcription factor for optimal expression of the Tec gene, and identify a unique functionally active NF-kappaB binding site in its promoter. The NF-kappaB subunit p65/RelA directly induced transcriptional activity of the Tec promoter. Moreover, we also found that proteasome inhibitors, including Bortezomib, repress Tec transcription through inactivation of the NF-kappaB signaling pathway. This study, together with our previous findings on the transcriptional regulation of Btk (Bruton's tyrosine kinase) by proteasome inhibitors, provides important insight into the molecular mechanism(s) underlying the role of NF-kappaB in Tec family kinase signaling and lymphocyte development.

  19. Total electron count variability and stratospheric ozone effects on solar backscatter and LWIR emissions

    Science.gov (United States)

    Ross, John S.; Fiorino, Steven T.

    2017-05-01

    The development of an accurate ionospheric Total Electron Count (TEC) model is of critical importance to high frequency (HF) radio propagation and satellite communications. However, the TEC is highly variable and is continually influenced by geomagnetic storms, extreme UV radiation, and planetary waves. Being able to capture this variability is essential to improve current TEC models. The growing body of data involving ionospheric fluctuations and stratospheric variations has revealed a correlation. In particular, there is a marked and persistent association between increases in stratospheric ozone and variability of the TEC. The spectral properties of ozone show that it is a greenhouse gas that alters long wave emissions from Earth and interacts with the UV spectrum coming from the sun. This study uses the Laser Environment Effects Definition and Reference (LEEDR) radiative transfer and atmospheric characterization code to model the effects of changes in stratospheric ozone on solar backscatter and longwave (LWIR) terrestrial emissions and infer TEC and TEC variability.

  20. Optimal design of an atmospheric water generator (AWG) based on thermo-electric cooler (TEC) for drought in rural area

    Science.gov (United States)

    Suryaningsih, Sri; Nurhilal, Otong

    2016-02-01

    Drinking water availability is a major issue in some rural area in Indonesia during the summer season due to lack of rainfall, which peoples in this area have to fetch the water a few kilometers away from home. The Atmospheric Water Generator (AWG) is one of the alternative solution for fresh water recovery from atmosphere which is directly condensed the moisture content of water vapor from the air. This paper presents the method to develop a prototype of an AWG based on Thermo-electric cooler (TEC) that used 12 Volt DC, hence its suitability for using renewable energy resource. Computational Fluid Dynamics (CFD) is utilized to optimize the design process in the flow region only, it's not suitable for recent CFD software to use in Multi physics, because inaccuracy, cost and time saving. Some parameters such as temperature, moisture content, air flow, pressure, form of air flow channel and the water productivity per unit input of energy are to be considered. The result is presented as an experimental prototype of an AWG based on TEC and compared with other conventional commercial products.

  1. Hydrothermal Synthesis and Mechanism of Unusual Zigzag Ag2Te and Ag2Te/C Core-Shell Nanostructures

    Directory of Open Access Journals (Sweden)

    Saima Manzoor

    2014-01-01

    Full Text Available A single step surfactant-assisted hydrothermal route has been developed for the synthesis of zigzag silver telluride nanowires with diameter of 50–60 nm and length of several tens of micrometers. Silver nitrate (AgNO3 and sodium tellurite (Na2TeO3, are the precursors and polyvinylpyrrolidone (PVP is used as surfactant in the presence of the reducing agent, that is, hydrazine hydrate (N2H4·H2O. In addition to the zigzag nanowires a facile hydrothermal reduction-carbonization route is proposed for the preparation of uniform core-shell Ag2Te/C nanowires. In case of Ag2Te/C synthesis process the same precursors are employed for Ag and Te along with the ethylene glycol used as reducing agent and glucose as the carbonizing agent. Morphological and compositional properties of the prepared products are analyzed with the help of scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy, respectively. The detailed formation mechanism of the zigzag morphology and reduction-carbonization growth mechanism for core-shell nanowires are illustrated on the bases of experimental results.

  2. XML and its impact on content and structure in electronic health care documents.

    Science.gov (United States)

    Sokolowski, R.; Dudeck, J.

    1999-01-01

    Worldwide information networks have the requirement that electronic documents must be easily accessible, portable, flexible and system-independent. With the development of XML (eXtensible Markup Language), the future of electronic documents, health care informatics and the Web itself are about to change. The intent of the recently formed ASTM E31.25 subcommittee, "XML DTDs for Health Care", is to develop standard electronic document representations of paper-based health care documents and forms. A goal of the subcommittee is to work together to enhance existing levels of interoperability among the various XML/SGML standardization efforts, products and systems in health care. The ASTM E31.25 subcommittee uses common practices and software standards to develop the implementation recommendations for XML documents in health care. The implementation recommendations are being developed to standardize the many different structures of documents. These recommendations are in the form of a set of standard DTDs, or document type definitions that match the electronic document requirements in the health care industry. This paper discusses recent efforts of the ASTM E31.25 subcommittee. PMID:10566338

  3. Comparison of the effect of X-ray and electron beam irradiation on the thiamine content in chicken drumsticks

    International Nuclear Information System (INIS)

    Calenberg, S. van; Cleemput, O. van; Huyghebaert, A.; Mondelaers, W.

    1998-01-01

    The effect of irradiation with X-rays and electron beams on the thiamine content of chicken drumsticks in function of the storage time at refrigerator temperature was examined. A measurement of the total colony count was used as an indication of the preservation time. The irradiation dose applied ranged from 0 to 7 kGy at dose rates of 0.05 and 5 kGy/min for X-rays and electron beams respectively. It was concluded that differences in the thiamine breakdown between the two types of irradiation increased as the dose increased. In the worst case, at the X-ray treatment of 7 kGy, the mean loss in thiamine was 46.06%

  4. HDAC3 Is a Master Regulator of mTEC Development

    Directory of Open Access Journals (Sweden)

    Yael Goldfarb

    2016-04-01

    Full Text Available The thymus provides a unique microenvironment enabling development and selection of T lymphocytes. Medullary thymic epithelial cells (mTECs play a pivotal role in this process by facilitating negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T cells. Although studies have highlighted the non-canonical nuclear factor κB (NF-κB pathway as the key regulator of mTEC development, comprehensive understanding of the molecular pathways regulating this process still remains incomplete. Here, we demonstrate that the development of functionally competent mTECs is regulated by the histone deacetylase 3 (Hdac3. Although histone deacetylases are global transcriptional regulators, this effect is highly specific only to Hdac3, as neither Hdac1 nor Hdac2 inactivation caused mTEC ablation. Interestingly, Hdac3 induces an mTEC-specific transcriptional program independently of the previously recognized RANK-NFκB signaling pathway. Thus, our findings uncover yet another layer of complexity of TEC lineage divergence and highlight Hdac3 as a major and specific molecular switch crucial for mTEC differentiation.

  5. Tec kinase mediating IL-8 transcription in monocytes stimulated with LPS.

    Science.gov (United States)

    Wang, Guang-Qing; Yang, Xiao-Yan; Jia, Yi-Tao; Xia, Zhao-Fan

    2009-08-01

    The purpose of present study was to explore the possibility of Tec kinase as a mediator for IL-8 transcription in monocytes stimulated with LPS. Plasmids of mouse Tec kinase IV or Tec kinase IV with inactivating point mutations generated with QuikChange site-directed mutagenesis were co-transfected with IL-8 promoter driven luciferase construct into RAW264.7 cells, then luciferase activity was measured with a luminometer. The results shown Tec kinase could significantly enhance IL-8 transcription. Furthermore, point inactivating mutation in SH2, PH or PTK domain almost completely abolish the effects of Tec kinase on the transcription of IL-8. In the transfection experiment, PD98059, a MEK1 inhibitor, decreased the transcription of IL-8 in a dose dependent pattern. When siRNA for Tec kinase was transfected into THP-1 cells, it could efficiently block the production of IL-8 from THP-1 cells (p Tec kinase may mediate the transcription of IL-8 in monocyte stimulated with LPS.

  6. The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.

    Science.gov (United States)

    Tampella, Giacomo; Kerns, Hannah M; Niu, Deqiang; Singh, Swati; Khim, Socheath; Bosch, Katherine A; Garrett, Meghan E; Moguche, Albanus; Evans, Erica; Browning, Beth; Jahan, Tahmina A; Nacht, Mariana; Wolf-Yadlin, Alejandro; Plebani, Alessandro; Hamerman, Jessica A; Rawlings, David J; James, Richard G

    2015-07-01

    Previous work has shown conflicting roles for Tec family kinases in regulation of TLR-dependent signaling in myeloid cells. In the present study, we performed a detailed investigation of the role of the Tec kinases Btk and Tec kinases in regulating TLR signaling in several types of primary murine macrophages. We demonstrate that primary resident peritoneal macrophages deficient for Btk and Tec secrete less proinflammatory cytokines in response to TLR stimulation than do wild-type cells. In contrast, we found that bone marrow-derived and thioglycollate-elicited peritoneal macrophages deficient for Btk and Tec secrete more proinflammatory cytokines than do wild-type cells. We then compared the phosphoproteome regulated by Tec kinases and LPS in primary peritoneal and bone marrow-derived macrophages. From this analysis we determined that Tec kinases regulate different signaling programs in these cell types. In additional studies using bone marrow-derived macrophages, we found that Tec and Btk promote phosphorylation events necessary for immunoreceptor-mediated inhibition of TLR signaling. Taken together, our results are consistent with a model where Tec kinases (Btk, Tec, Bmx) are required for TLR-dependent signaling in many types of myeloid cells. However, our data also support a cell type-specific TLR inhibitory role for Btk and Tec that is mediated by immunoreceptor activation and signaling via PI3K. Copyright © 2015 by The American Association of Immunologists, Inc.

  7. Analysis and design for the thermo-smart structure of composite with TEC

    Science.gov (United States)

    Deng, Zhong-Min; Cheng, Xian-Li; Wang, Xiao-Qun

    2007-07-01

    Based on the properties of thermoelectric cooler (TEC), a thermal analysis model for the thermo-smart structure of composite with TECs is built. Some parameters which affect the temperature distribution of the structure are designed, such as the location of TECs and the thermal boundary conditions. A temperature control system is designed for the thermo-smart structure and simulated in SIMULINK. The results of simulation indicate that the structure combined with PI controller performs greatly to temperature control. The applications of smart thermal structure on cooling design of computer chips and infrared stealth will benefit from the paper's results.

  8. Curriculum Change Part 2a. Programme Development in Colleges. Part 2a: The Work Activities of Teachers on TEC Certificate Programmes.

    Science.gov (United States)

    Dodd, S.; And Others

    A study examined the day-to-day work activities of teachers of Technician Education Council (TEC) certificate programs in Great Britain. During the study, a detailed questionnaire dealing with the tasks performed by TEC teachers, the amount of time spent on TEC teachers on individual activities, and the impact of the TEC programs on teacher…

  9. Electron microscopy and NMR studies of vanadium content effect on Fe-Co alloy structure

    International Nuclear Information System (INIS)

    Alekseev, L.A.; Dzhavadov, D.M.; Tyapkin, Yu.D.; Levin, R.B.

    1977-01-01

    The Fe-Co and Fe-Co-V alloys have been studied in the state after hardening (850 deg) and the following tempering (450-525 deg C). It is shown that the addition of V up to 2 at% decelerates the ordering process, whereas 1 at% Cr virtually completely suppresses it. No appreciable redistribution of V atoms occurs in non-strained Fe-Co alloys during their tempering. In course of annealing of cold-strained Fe-Co alloys with 1 at% V clusters with increased V contents (up to 8 at%) are forming at dislocations. The symmetry of atomic positions in the clusters differs from that in the matrix

  10. Electronic Cigarette Refill Liquids: Child-Resistant Packaging, Nicotine Content, and Sales to Minors2

    Science.gov (United States)

    Buettner-Schmidt, Kelly; Miller, Donald R.; Balasubramanian, Narayanaganesh

    2016-01-01

    Purpose To determine the accuracy of the labeled quantity of the nicotine content of the e-liquids sold in unlicensed vape stores, whether the packaging of e-liquids sold within the vape stores was child-resistant, whether minors were present within vape stores, and whether sales to minors occurred. This study was conducted across North Dakota prior to implementation of a new e-cigarette state law and provided a baseline assessment before enactment of the new legal requirements. Design and Methods We tested samples of e-liquids and performed observations in 16 stores that were selling e-cigarettes but were not legally required to be licensed for tobacco retail. The e-liquids were analyzed for nicotine content using a validated high-performance liquid chromatography method for nicotine analysis. Results Of the 70 collected e-liquid samples that claimed to contain nicotine, 17% contained more than the labeled quantity and 34% contained less than the labeled quantity by 10% or more, with one sample containing 172% more than the labeled quantity. Of the 94 e-liquid containers sampled, only 35% were determined to be child-resistant. Minors were present in stores, although no sales to minors occurred. Conclusions Mislabeling of nicotine in e-liquids is common and exposes the user to the harmful effects of nicotine. The lack of child-resistant packaging for this potentially toxic substance is a serious public health problem. E-cigarettes should be included in the legal definition of tobacco products, child-resistant packaging and nicotine labeling laws should be enacted and strictly enforced, and vape stores should be licensed by states. PMID:27079973

  11. Electronic Cigarette Refill Liquids: Child-Resistant Packaging, Nicotine Content, and Sales to Minors.

    Science.gov (United States)

    Buettner-Schmidt, Kelly; Miller, Donald R; Balasubramanian, Narayanaganesh

    2016-01-01

    To determine the accuracy of the labeled quantity of the nicotine content of the e-liquids sold in unlicensed vape stores, whether the packaging of e-liquids sold within the vape stores was child-resistant, whether minors were present within vape stores, and whether sales to minors occurred. This study was conducted across North Dakota prior to implementation of a new e-cigarette state law and provided a baseline assessment before enactment of the new legal requirements. We tested samples of e-liquids and performed observations in 16 stores that were selling e-cigarettes but were not legally required to be licensed for tobacco retail. The e-liquids were analyzed for nicotine content using a validated high-performance liquid chromatography method for nicotine analysis. Of the 70 collected e-liquid samples that claimed to contain nicotine, 17% contained more than the labeled quantity and 34% contained less than the labeled quantity by 10% or more, with one sample containing 172% more than the labeled quantity. Of the 94 e-liquid containers sampled, only 35% were determined to be child-resistant. Minors were present in stores, although no sales to minors occurred. Mislabeling of nicotine in e-liquids is common and exposes the user to the harmful effects of nicotine. The lack of child-resistant packaging for this potentially toxic substance is a serious public health problem. E-cigarettes should be included in the legal definition of tobacco products, child-resistant packaging and nicotine labeling laws should be enacted and strictly enforced, and vape stores should be licensed by states. Copyright © 2016 Elsevier Inc. All rights reserved.

  12. “Smoking Revolution” A Content Analysis of Electronic Cigarette Retail Websites

    Science.gov (United States)

    Grana, Rachel A.; Ling, Pamela M.

    2014-01-01

    Background Electronic cigarettes (e-cigarettes) have been increasingly available and marketed in the U.S. since 2007. As patterns of product adoption are frequently driven and reinforced by marketing, it is important to understand the marketing claims encountered by consumers. Purpose To describe the main advertising claims made on branded e-cigarette retail websites. Methods Websites were retrieved from two major search engines in 2011 using iterative searches with the following terms: electronic cigarette, e-cigarette, e-cig, and personal vaporizer. Fifty-nine websites met inclusion criteria, and 13 marketing claims were coded for main marketing messages in 2012. Results Ninety-five percent of the websites made explicit or implicit health-related claims, 64% had a smoking cessation-related claim, 22% featured doctors, and 76% claimed that the product does not produce secondhand smoke. Comparisons to cigarettes included claims that e-cigarettes were cleaner (95%) and cheaper (93%). Eighty-eight percent stated that the product could be smoked anywhere and 71% mentioned using the product to circumvent clean air policies. Candy, fruit, and coffee flavors were offered on most sites. Youthful appeals included images or claims of modernity (73%), increased social status (44%), enhanced social activity (32%), romance (31%), and use by celebrities (22%). Conclusions Health claims and smoking cessation messages that are unsupported by current scientific evidence are frequently used to sell e-cigarettes. Implied and overt health claims, the presence of doctors on websites, celebrity endorsements, and the use of characterizing flavors should be prohibited. PMID:24650842

  13. Data Assimilation of Ground-Based GPS and Radio Occultation Total Electron Content for Global Ionospheric Specification

    Science.gov (United States)

    Lin, C. Y.; Matsuo, T.; Liu, J. Y.; Lin, C. H.; Huba, J. D.; Tsai, H. F.; Chen, C. Y.

    2017-10-01

    This study presents an approach based on the Gauss-Markov Kalman filter to assimilate the total electron content observed from ground-based GPS receivers and space-based radio occultation instrumentations (such as FORMOSAT-3/COSMIC (F3/C) and FORMOSAT-7/COSMIC-2 (F7/C2)) into the International Reference Ionosphere. Observing System Simulation Experiments (OSSEs) show that the data assimilation procedure consisting of the forecast and the measurement update steps can better improve the accuracy of the data assimilation analysis than the assimilation procedure using the measurement update alone. Compared with F3/C, the denser F7/C2 occultation observations can improve the analysis accuracy significantly as suggested by OSSEs. The real data assimilation results are further validated with global ionosphere maps, the global ground-based GPS measurements, and the ionospheric F2 peak height and electron density sounded by ionosondes. Both the OSSEs and validation results confirm that a number of improvements to the data assimilation procedure presented in this paper can indeed be used to reconstruct the three-dimensional ionospheric electron density adequately.

  14. A switch in nucleotide affinity governs activation of the Src and Tec family kinases.

    Science.gov (United States)

    von Raußendorf, Freia; de Ruiter, Anita; Leonard, Thomas A

    2017-12-12

    The Tec kinases, closely related to Src family kinases, are essential for lymphocyte function in the adaptive immune system. Whilst the Src and Abl kinases are regulated by tail phosphorylation and N-terminal myristoylation respectively, the Tec kinases are notable for the absence of either regulatory element. We have found that the inactive conformations of the Tec kinase Itk and Src preferentially bind ADP over ATP, stabilising both proteins. We demonstrate that Itk adopts the same conformation as Src and that the autoinhibited conformation of Src is independent of its C-terminal tail. Allosteric activation of both Itk and Src depends critically on the disruption of a conserved hydrophobic stack that accompanies regulatory domain displacement. We show that a conformational switch permits the exchange of ADP for ATP, leading to efficient autophosphorylation and full activation. In summary, we propose a universal mechanism for the activation and autoinhibition of the Src and Tec kinases.

  15. Tec family kinases: regulation of FcεRI-mediated mast-cell activation.

    Science.gov (United States)

    Ellmeier, Wilfried; Abramova, Anastasia; Schebesta, Alexandra

    2011-06-01

    Mast cells express the high-affinity receptor for IgE (FcεRI) and are key players in type I hypersensitivity reactions. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis, however, they also regulate normal physiological processes that link innate and adaptive immune responses. Thus, their activation has to be tightly controlled. One group of signaling molecules that are activated upon FcεRI stimulation is formed by Tec family kinases, and three members of this kinase family (Btk, Itk and Tec) are expressed in mast cells. Many studies have revealed important functions of Tec kinases in signaling pathways downstream of the antigen receptors in lymphocytes. This review summarizes the current knowledge about the function of Tec family kinases in FcεRI-mediated signaling pathways in mast cell. © 2011 The Authors Journal compilation © 2011 FEBS.

  16. Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.

    Science.gov (United States)

    Liu, Chih-Chun; Lai, Chen-Yen; Yen, Wei-Feng; Lin, Yu-Hsien; Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Yu-Jung; Tsao, Hsiao-Wei; Ho, I-Cheng; Miaw, Shi-Chuen

    2015-01-01

    C-Maf plays an important role in regulating cytokine production in TH cells. Its transactivation of IL-4 is optimized by phosphorylation at Tyr21, Tyr92, and Tyr131. However, the molecular mechanism regulating its tyrosine phosphorylation remains unknown. In this study, we demonstrate that Tec kinase family member Tec, but not Rlk or Itk, is a tyrosine kinase of c-Maf and that Tec enhances c-Maf-dependent IL-4 promoter activity. This effect of Tec is counteracted by Ptpn22, which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf thereby attenuating its transcriptional activity. We further show that phosphorylation of Tyr21/92/131 of c-Maf is also critical for its recruitment to the IL-21 promoter and optimal production of this cytokine by TH17 cells. Thus, manipulating tyrosine phosphorylation of c-Maf through its kinases and phosphatases can have significant impact on TH cell-mediated immune responses.

  17. A new electron density model of the plasmasphere for operational applications and services

    Science.gov (United States)

    Jakowski, Norbert; Hoque, Mohammed Mainul

    2018-03-01

    The Earth's plasmasphere contributes essentially to total electron content (TEC) measurements from ground or satellite platforms. Furthermore, as an integral part of space weather, associated plasmaspheric phenomena must be addressed in conjunction with ionosphere weather monitoring by operational space weather services. For supporting space weather services and mitigation of propagation errors in Global Navigation Satellite Systems (GNSS) applications we have developed the empirical Neustrelitz plasmasphere model (NPSM). The model consists of an upper L shell dependent part and a lower altitude dependent part, both described by specific exponential decays. Here the McIllwain parameter L defines the geomagnetic field lines in a centered dipole model for the geomagnetic field. The coefficients of the developed approaches are successfully fitted to numerous electron density data derived from dual frequency GPS measurements on-board the CHAMP satellite mission from 2000 to 2005. The data are utilized for fitting up to the L shell L = 3 because a previous validation has shown a good agreement with IMAGE/RPI measurements up to this value. Using the solar radio flux index F10.7 as the only external parameter, the operation of the model is robust, with 40 coefficients fast and sufficiently accurate to be used as a background model for estimating TEC or electron density profiles in near real time GNSS applications and services. In addition to this, the model approach is sensitive to ionospheric coupling resulting in anomalies such as the Nighttime Winter Anomaly and the related Mid-Summer Nighttime Anomaly and even shows a slight plasmasphere compression of the dayside plasmasphere due to solar wind pressure. Modelled electron density and TEC values agree with estimates reported in the literature in similar cases.

  18. Harmonic analysis of the ionospheric electron densities retrieved from FORMOSAT-3/COSMIC radio occultation measurements

    Science.gov (United States)

    Masoumi, S.; Safari, A.; Sharifi, M.; Sam Khaniani, A.

    2011-12-01

    In order to investigate regular variations of the ionosphere, the least-squares harmonic estimation is applied to the time series of ionospheric electron densities in the region of Iran derived from about five years of Global Positioning System Radio Occultation (GPS RO) observations by FORMOSAT-3/COSMIC satellites. Although the obtained results are slightly different from the expected ones due to the low horizontal resolution of RO measurements, high vertical resolution of the observations enables us to detect not only the Total Electron Content (TEC) variations, but also periodic patterns of electron densities in different altitudes of the ionosphere. Dominant diurnal and annual signals, together with their Fourier series decompositions, and also periods close to 27 days are obtained, which is consistent with the previous analyses on TEC. In the equatorial anomaly band, the annual component is weaker than its Fourier decomposition periods. In particular, the semiannual period dominates the annual component, which is probably due to the effect of geomagnetic field. By the investigation of the frequencies at different local times, the semiannual signal is more significant than the annual one in the daytime, while the annual frequency is dominant at night. By the detection of the phases of the components, it is revealed that the annual signal has its maximum in summer at high altitudes, and in winter at lower altitudes. This suggests the effect of neutral compositions in the lower atmosphere. Further, the semiannual component peaks around equinox during the day, while its maximum mostly occurs in solstice at night. Since RO measurements can be used to derive TEC along the signal path between a GPS satellite and a receiver, study on the potentiality of using these observations for the prediction of electron densities and its application to the ionospheric correction of the single frequency receivers is suggested.

  19. PROTEST AND CONSUMER: A CONTENT ANALYSIS OF EBSCO ELECTRONIC DATABASE ACROSS 50 YEARS

    Directory of Open Access Journals (Sweden)

    Kresno A. Hendarto

    2014-02-01

    Full Text Available AbstractThe objective of this research is to review the articles of protest and consumer in EBSCO electronic journal. The objective will be achieved by answering the following questions: (i what is the method of reviewed articles with the topic of protest; and (ii what agenda of future research? The results showed that most reviewed articles  used qualitative approach. Most research are empirical in nature. For articles of empirical research, most of the data were obtained through observation and were analyzed descriptively. Literature on protest and consumer can be classified into 3 main categories: (1 discussing about the frequency, cause, and objective of protest; (2 discussing about the consequence of protest; and (3 discussing about the  motivation of individuals in taking part in the protest. This review also showed that there are major gaps from the previous research including the fact that attitude is not the focal point in explaining why consumers take part in protest and no article discussed consumers’ attitude to the object taking part in the protest.  AbstrakTujuan penelitian ini adalah melakukan ulas balik artikel-artikel bertopik protes dan konsumen pada database elektronik EBSCO. Tujuan tersebut akan dicapai dengan menjawab pertanyaan penelitian sebagai berikut: (i apa metode dan sifat dasar dari artikel yang bertopik protes; dan (ii agenda penelitian apa yang masih terbuka ke depan? Hasil analisis menunjukkan bahwa kebanyakan artikel yang direview menggunakan pendekatan kualitatif. Kebanyakan artikel merupakan penelitian empiris. Untuk artikel penelitian empiris, mayoritas data diperoleh dengan cara observasi, dan dianalisis secara deskriptif. Literatur tentang protes dan konsumen dapat digolongkan dalam 3 bagian besar, yaitu (1 yang membahas tentang frekuensi, sebab, dan tujuan protes; (2 yang membahas tentang konsekuensi dari protes; dan (3 yang membahas tentang motivasi individu yang mendasari untuk berpartisipasi dalam

  20. A dual-stage sodium thermal electrochemical converter (Na-TEC)

    Science.gov (United States)

    Limia, Alexander; Ha, Jong Min; Kottke, Peter; Gunawan, Andrey; Fedorov, Andrei G.; Lee, Seung Woo; Yee, Shannon K.

    2017-12-01

    The sodium thermal electrochemical converter (Na-TEC) is a heat engine that generates electricity through the isothermal expansion of sodium ions. The Na-TEC is a closed system that can theoretically achieve conversion efficiencies above 45% when operating between thermal reservoirs at 1150 K and 550 K. However, thermal designs have confined previous single-stage devices to thermal efficiencies below 20%. To mitigate some of these limitations, we consider dividing the isothermal expansion into two stages; one at the evaporator temperature (1150 K) and another at an intermediate temperature (650 K-1050 K). This dual-stage Na-TEC takes advantage of regeneration and reheating, and could be amenable to better thermal management. Herein, we demonstrate how the dual-stage device can improve the efficiency by up to 8% points over the best performing single-stage device. We also establish an application regime map for the single- and dual-stage Na-TEC in terms of the power density and the total thermal parasitic loss. Generally, a single-stage Na-TEC should be used for applications requiring high power densities, whereas a dual-stage Na-TEC should be used for applications requiring high efficiency.

  1. Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2*

    Science.gov (United States)

    La Venuta, Giuseppe; Wegehingel, Sabine; Sehr, Peter; Müller, Hans-Michael; Dimou, Eleni; Steringer, Julia P.; Grotwinkel, Mareike; Hentze, Nikolai; Mayer, Matthias P.; Will, David W.; Uhrig, Ulrike; Lewis, Joe D.; Nickel, Walter

    2016-01-01

    Fibroblast growth factor 2 (FGF2) is a potent mitogen promoting both tumor cell survival and tumor-induced angiogenesis. It is secreted by an unconventional secretory mechanism that is based upon direct translocation across the plasma membrane. Key steps of this process are (i) phosphoinositide-dependent membrane recruitment, (ii) FGF2 oligomerization and membrane pore formation, and (iii) extracellular trapping mediated by membrane-proximal heparan sulfate proteoglycans. Efficient secretion of FGF2 is supported by Tec kinase that stimulates membrane pore formation based upon tyrosine phosphorylation of FGF2. Here, we report the biochemical characterization of the direct interaction between FGF2 and Tec kinase as well as the identification of small molecules that inhibit (i) the interaction of FGF2 with Tec, (ii) tyrosine phosphorylation of FGF2 mediated by Tec in vitro and in a cellular context, and (iii) unconventional secretion of FGF2 from cells. We further demonstrate the specificity of these inhibitors for FGF2 because tyrosine phosphorylation of a different substrate of Tec is unaffected in their presence. Building on previous evidence using RNA interference, the identified compounds corroborate the role of Tec kinase in unconventional secretion of FGF2. In addition, they are valuable lead compounds with great potential for drug development aiming at the inhibition of FGF2-dependent tumor growth and metastasis. PMID:27382052

  2. Optical power of VCSELs stabilized to 35 ppm/°C without a TEC

    Science.gov (United States)

    Downing, John

    2015-03-01

    This paper reports a method and system comprising a light source, an electronic method, and a calibration procedure for stabilizing the optical power of vertical-cavity surface-emitting lasers (VCSELs) and laser diodes (LDs) without the use thermoelectric coolers (TECs). The system eliminates the needs for custom interference coatings, polarization adjustments, and the exact alignment required by the optical method reported in 2013 [1]. It can precisely compensate for the effects of temperature and wavelength drift on photodiode responsivity as well as changes in VCSEL beam quality and polarization angle over a 50°C temperature range. Data obtained from light sources built with single-mode polarization-locked VCSELs demonstrate that 30 ppm/°C stability can be readily obtained. The system has advantages over TECstabilized laser modules that include: 1) 90% lower relative RMS optical power and temperature sensitivity, 2) a five-fold enhancement of wall-plug efficiency, 3) less component testing and sorting, 4) lower manufacturing costs, and 5) automated calibration in batches at time of manufacture is practical. The system is ideally suited for battery-powered environmental and in-home medical monitoring applications.

  3. Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects.

    Science.gov (United States)

    Conley, Kevin E; Amara, Catherine E; Bajpeyi, Sudip; Costford, Sheila R; Murray, Kori; Jubrias, Sharon A; Arakaki, Lori; Marcinek, David J; Smith, Steven R

    2013-01-01

    This study investigated the disparity between muscle metabolic rate and mitochondrial metabolism in human muscle of sedentary vs. active individuals. Chronic activity level was characterized by a physical activity questionnaire and a triaxial accelerometer as well as a maximal oxygen uptake test. The ATP and O(2) fluxes and mitochondrial coupling (ATP/O(2) or P/O) in resting muscle as well as mitochondrial capacity (ATP(max)) were determined in vivo in human vastus lateralis muscle using magnetic resonance and optical spectroscopy on 24 sedentary and seven active subjects. Muscle biopsies were analyzed for electron transport chain content (using complex III as a representative marker) and mitochondrial proteins associated with antioxidant protection. Sedentary muscle had lower electron transport chain complex content (65% of the active group) in proportion to the reduction in ATP(max) (0.69 ± 0.07 vs. 1.07 ± 0.06 mM sec(-1)) as compared with active subjects. This lower ATP(max) paired with an unchanged O(2) flux in resting muscle between groups resulted in a doubling of O(2) flux per ATP(max) (3.3 ± 0.3 vs. 1.7 ± 0.2 μM O(2) per mM ATP) that reflected mitochondrial uncoupling (P/O = 1.41 ± 0.1 vs. 2.1 ± 0.3) and greater UCP3/complex III (6.0 ± 0.7 vs. 3.8 ± 0.3) in sedentary vs. active subjects. A smaller mitochondrial pool serving the same O(2) flux resulted in elevated mitochondrial respiration in sedentary muscle. In addition, uncoupling contributed to this higher mitochondrial respiration. This finding resolves the paradox of stable muscle metabolism but greater mitochondrial respiration in muscle of inactive vs. active subjects.

  4. Variations of the ionospheric electron density during the Bhuj seismic event

    Directory of Open Access Journals (Sweden)

    A. Trigunait

    2004-12-01

    Full Text Available Ionospheric perturbations by natural geophysical activity, such as volcanic eruptions and earthquakes, have been studied since the great Alaskan earthquake in 1964. Measurements made from the ground show a variation of the critical frequency of the ionosphere layers before and after the shock. In this paper, we present an experimental investigation of the electron density variations around the time of the Bhuj earthquake in Gujarat, India. Several experiments have been used to survey the ionosphere. Measurements of fluctuations in the integrated electron density or TEC (Total Electron Content between three satellites (TOPEX-POSEIDON, SPOT2, SPOT4 and the ground have been done using the DORIS beacons. TEC has been also evaluated from a ground-based station using GPS satellites, and finally, ionospheric data from a classical ionospheric sounder located close to the earthquake epicenter are utilized. Anomalous electron density variations are detected both in day and night times before the quake. The generation mechanism of these perturbations is explained by a modification of the electric field in the global electric circuit induced during the earthquake preparation. Key words. Ionosphere (ionospheric disturbances – Radio Science (ionospheric physics – History of geophysics (seismology

  5. Introducing E-tec: Ensemble-based Topological Entropy Calculation

    Science.gov (United States)

    Roberts, Eric; Smith, Spencer; Sindi, Suzanne; Smith, Kevin

    2017-11-01

    Topological entropy is a measurement of orbit complexity in a dynamical system that can be estimated in 2D by embedding an initial material curve L0 in the fluid and estimating its growth under the evolution of the flow. This growth is given by L (t) = | L0 | eht , where L (t) is the length of the curve as a function of t and h is the topological entropy. In order to develop a method for computing Eq. (1) that will efficiently scale up in both system size and modeling time, one must be clever about extracting the maximum information from the limited trajectories available. The relative motion of trajectories through phase space encodes global information that is not contained in any individual trajectory. That is, extra information is ''hiding'' in an ensemble of classical trajectories, which is not exploited in a trajectory-by-trajectory approach. Using tools from computational geometry, we introduce a new algorithm designed to take advantage of such additional information that requires only potentially sparse sets of particle trajectories as input and no reliance on any detailed knowledge of the velocity field: the Ensemble-Based Topological Entropy Calculation, or E-tec.

  6. AzTEC on ASTE Survey of Submillimeter Galaxies

    Science.gov (United States)

    Kohno, K.; Tamura, Y.; Hatsukade, B.; Nakanishi, K.; Iono, D.; Takata, T.; Wilson, G. W.; Yun, M. S.; Perera, T.; Austermann, J. E.; Scott, K. S.; Hughes, H.; Aretxaga, I.; Tanaka, K.; Oshima, T.; Yamaguchi, N.; Matsuo, H.; Ezawa, H.; Kawabe, R.

    2008-10-01

    We have conducted an unprecedented survey of submillimeter galaxies (SMGs) using the 144 pixel bolometer camera AzTEC mounted on the ASTE 10-m dish in Chile. We have already obtained many (>20) wide (typically 12' × 12' or wider) and deep (1 σ sensitivity of 0.5-1.0 mJy) 1.1 mm continuum images of known blank fields and over-density regions/protoclusters across a wide range of redshifts with a spatial resolution of ˜ 30''. It has resulted in the numerous (˜ a few 100, almost equivalent to the total number of the previously known SMGs) new and secure detections of SMGs. In this paper, we present initial results of two selected fields, SSA 22 and AKARI Deep Field South (ADF-S). A significnat clustering of bright SMGs toward the density peak of LAEs is found in SSA 22. We derived the differential and cumulative number counts from the detected sources in ADF-S, which probe the faintest flux densities (down to ˜1 mJy) among 1-mm blank field surveys to date.

  7. 100 Million Views of Electronic Cigarette YouTube Videos and Counting: Quantification, Content Evaluation, and Engagement Levels of Videos

    Science.gov (United States)

    2016-01-01

    Background The video-sharing website, YouTube, has become an important avenue for product marketing, including tobacco products. It may also serve as an important medium for promoting electronic cigarettes, which have rapidly increased in popularity and are heavily marketed online. While a few studies have examined a limited subset of tobacco-related videos on YouTube, none has explored e-cigarette videos’ overall presence on the platform. Objective To quantify e-cigarette-related videos on YouTube, assess their content, and characterize levels of engagement with those videos. Understanding promotion and discussion of e-cigarettes on YouTube may help clarify the platform’s impact on consumer attitudes and behaviors and inform regulations. Methods Using an automated crawling procedure and keyword rules, e-cigarette-related videos posted on YouTube and their associated metadata were collected between July 1, 2012, and June 30, 2013. Metadata were analyzed to describe posting and viewing time trends, number of views, comments, and ratings. Metadata were content coded for mentions of health, safety, smoking cessation, promotional offers, Web addresses, product types, top-selling brands, or names of celebrity endorsers. Results As of June 30, 2013, approximately 28,000 videos related to e-cigarettes were captured. Videos were posted by approximately 10,000 unique YouTube accounts, viewed more than 100 million times, rated over 380,000 times, and commented on more than 280,000 times. More than 2200 new videos were being uploaded every month by June 2013. The top 1% of most-viewed videos accounted for 44% of total views. Text fields for the majority of videos mentioned websites (70.11%); many referenced health (13.63%), safety (10.12%), smoking cessation (9.22%), or top e-cigarette brands (33.39%). The number of e-cigarette-related YouTube videos was projected to exceed 65,000 by the end of 2014, with approximately 190 million views. Conclusions YouTube is a major

  8. 100 Million Views of Electronic Cigarette YouTube Videos and Counting: Quantification, Content Evaluation, and Engagement Levels of Videos.

    Science.gov (United States)

    Huang, Jidong; Kornfield, Rachel; Emery, Sherry L

    2016-03-18

    The video-sharing website, YouTube, has become an important avenue for product marketing, including tobacco products. It may also serve as an important medium for promoting electronic cigarettes, which have rapidly increased in popularity and are heavily marketed online. While a few studies have examined a limited subset of tobacco-related videos on YouTube, none has explored e-cigarette videos' overall presence on the platform. To quantify e-cigarette-related videos on YouTube, assess their content, and characterize levels of engagement with those videos. Understanding promotion and discussion of e-cigarettes on YouTube may help clarify the platform's impact on consumer attitudes and behaviors and inform regulations. Using an automated crawling procedure and keyword rules, e-cigarette-related videos posted on YouTube and their associated metadata were collected between July 1, 2012, and June 30, 2013. Metadata were analyzed to describe posting and viewing time trends, number of views, comments, and ratings. Metadata were content coded for mentions of health, safety, smoking cessation, promotional offers, Web addresses, product types, top-selling brands, or names of celebrity endorsers. As of June 30, 2013, approximately 28,000 videos related to e-cigarettes were captured. Videos were posted by approximately 10,000 unique YouTube accounts, viewed more than 100 million times, rated over 380,000 times, and commented on more than 280,000 times. More than 2200 new videos were being uploaded every month by June 2013. The top 1% of most-viewed videos accounted for 44% of total views. Text fields for the majority of videos mentioned websites (70.11%); many referenced health (13.63%), safety (10.12%), smoking cessation (9.22%), or top e-cigarette brands (33.39%). The number of e-cigarette-related YouTube videos was projected to exceed 65,000 by the end of 2014, with approximately 190 million views. YouTube is a major information-sharing platform for electronic cigarettes

  9. The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.

    Science.gov (United States)

    Zwolanek, Florian; Riedelberger, Michael; Stolz, Valentina; Jenull, Sabrina; Istel, Fabian; Köprülü, Afitap Derya; Ellmeier, Wilfried; Kuchler, Karl

    2014-12-01

    Tec family kinases are intracellular non-receptor tyrosine kinases implicated in numerous functions, including T cell and B cell regulation. However, a role in microbial pathogenesis has not been described. Here, we identified Tec kinase as a novel key mediator of the inflammatory immune response in macrophages invaded by the human fungal pathogen C. albicans. Tec is required for both activation and assembly of the noncanonical caspase-8, but not of the caspase-1 inflammasome, during infections with fungal but not bacterial pathogens, triggering the antifungal response through IL-1β. Furthermore, we identify dectin-1 as the pathogen recognition receptor being required for Syk-dependent Tec activation. Hence, Tec is a novel innate-specific inflammatory kinase, whose genetic ablation or inhibition by small molecule drugs strongly protects mice from fungal sepsis. These data demonstrate a therapeutic potential for Tec kinase inhibition to combat invasive microbial infections by attenuating the host inflammatory response.

  10. Comparison of plateletpheresis on the Fenwal Amicus, Fresenius COM.TEC, and Trima Accel Cell separators.

    Science.gov (United States)

    Keklik, Muzaffer; Eser, Bulent; Kaynar, Leylagul; Sivgin, Serdar; Keklik, Ertugrul; Solmaz, Musa; Ozturk, Ahmet; Buyukoglan, Ruksan; Yay, Mehmet; Cetin, Mustafa; Unal, Ali

    2015-06-01

    Blood component donations by apheresis have become more common in modern blood transfusion practices. We compared three apheresis instruments (Fenwal Amicus, Fresenius COM.TEC, and Trima Accel) with regard to platelet (PLT) yield, collection efficiency (CE), and collection rate (CR). The single-needle or double-needle plateletpheresis procedures of the three instruments were compared in a retrospective, randomized study in 270 donors. The blood volume processed was higher in the COM.TEC compared with the Amicus and Trima. Also there was a significantly higher median volume of ACD used in collections on the COM.TEC compared with the Amicus and Trima. The PLT yield was significantly lower with the COM.TEC compared with the Amicus and Trima. Additionally, the CE was significantly lower with the COM.TEC compared with the Amicus and Trima. There was no significant difference in median separation time and CR between the three groups. When procedures were compared regarding CE by using Amicus device, it was significantly higher in single-needle than double-needle plateletpheresis. When double-needle Amicus system was compared with double-needle COM.TEC system, CE and PLT yield were significantly higher with Amicus system. When single-needle Amicus system was compared with single-needle Trima system, CE and PLT yield were significantly higher with Trima system. All instruments collected PLTs efficiently. However, the CE was lower with the COM.TEC compared with the Amicus and Trima. Also, we found Amicus single-needle system collected PLTs more efficiently compared with the double-needle system. CE and PLT yields were significantly higher with the single-needle Trima instrument compared with the single-needle Amicus device. © 2014 Wiley Periodicals, Inc.

  11. Crystal-induced neutrophil activation: X. Proinflammatory role of the tyrosine kinase Tec.

    Science.gov (United States)

    Popa-Nita, Oana; Marois, Louis; Paré, Guillaume; Naccache, Paul H

    2008-06-01

    Monosodium urate monohydrate (MSU) crystals are among the most potent proinflammatory stimuli, and an innate immune inflammatory response to the crystal surface is involved in the pathogenesis of gouty arthritis. Release of the crystals into the joint cavity promotes an acute inflammation characterized by massive infiltration of neutrophils, which leads to tissue damage. The aim of the present study was to assess the involvement of the tyrosine kinase Tec in MSU crystal-initiated transduction events in human neutrophils. Immunoprecipitation and immunoblotting techniques were used for the cellular signaling studies. Chemotaxis and enzyme-linked immunosorbent assay techniques were used for the functional studies. Silencing of Tec expression using specific small interfering RNA was also performed. MSU crystals induced the phosphorylation and activation of Tec in a Src-dependent manner. This activation was necessary for the MSU crystal-induced secretion of interleukin-1beta (IL-1beta) and IL-8 and for the generation of chemotactic activity in supernatants of MSU crystal-stimulated neutrophils. In addition, colchicine, an effective drug for the treatment of gout, inhibited the MSU crystal-induced tyrosine phosphorylation of Tec, thus modulating its kinase activity. Our findings show that Tec is the principal kinase of the Tec family that plays a major role in the responses of human neutrophils to MSU crystals, which are likely to be involved in the initiation and perpetuation of gout. Our results suggest that the specific inhibition of Tec during the acute phase of MSU crystal-induced inflammation may be considered for the treatment of gouty arthritis.

  12. Analysis of the IMAGE RPI electron density data and CHAMP plasmasphere electron density reconstructions with focus on plasmasphere modelling

    Science.gov (United States)

    Gerzen, T.; Feltens, J.; Jakowski, N.; Galkin, I.; Reinisch, B.; Zandbergen, R.

    2016-09-01

    The electron density of the topside ionosphere and the plasmasphere contributes essentially to the overall Total Electron Content (TEC) budget affecting Global Navigation Satellite Systems (GNSS) signals. The plasmasphere can cause half or even more of the GNSS range error budget due to ionospheric propagation errors. This paper presents a comparative study of different plasmasphere and topside ionosphere data aiming at establishing an appropriate database for plasmasphere modelling. We analyze electron density profiles along the geomagnetic field lines derived from the Imager for Magnetopause-to-Aurora Global Exploration (IMAGE) satellite/Radio Plasma Imager (RPI) records of remote plasma sounding with radio waves. We compare these RPI profiles with 2D reconstructions of the topside ionosphere and plasmasphere electron density derived from GNSS based TEC measurements onboard the Challenging Minisatellite Payload (CHAMP) satellite. Most of the coincidences between IMAGE profiles and CHAMP reconstructions are detected in the region with L-shell between 2 and 5. In general the CHAMP reconstructed electron densities are below the IMAGE profile densities, with median of the CHAMP minus IMAGE residuals around -588 cm-3. Additionally, a comparison is made with electron densities derived from passive radio wave RPI measurements onboard the IMAGE satellite. Over the available 2001-2005 period of IMAGE measurements, the considered combined data from the active and passive RPI operations cover the region within a latitude range of ±60°N, all longitudes, and an L-shell ranging from 1.2 to 15. In the coincidence regions (mainly 2 ⩽ L ⩽ 4), we check the agreement between available active and passive RPI data. The comparison shows that the measurements are well correlated, with a median residual of ∼52 cm-3. The RMS and STD values of the relative residuals are around 22% and 21% respectively. In summary, the results encourage the application of IMAGE RPI data for

  13. Application of Geostationary GNSS and SBAS Satellites for Studying Ionospheric TEC Disturbances of Geomagnetic and Meteorological Origin

    Science.gov (United States)

    Padokhin, A. M.; Kurbatov, G. A.; Yasyukevich, Y.; Yasyukevich, A.

    2017-12-01

    With the development of GNSS and SBAS constellations, the coherent multi-frequency L band transmissions are now available from a number of geostationary satellites. These signals can be used for ionospheric TEC estimations in the same way as widely used GPS/GLONASS signals. In this work, we compare noise patterns in TEC estimations based on different geostationary satellites data: augmentation systems (Indian GAGAN, European EGNOS and American WAAS), and Chinese COMPASS/Beidou navigation system. We show that noise level in geostationary COMPASS/Beidou TEC estimations is times smaller than noise in SBAS TEC estimation and corresponds to those of GPS/GLONASS at the same elevation angles. We discuss the capabilities of geostationary TEC data for studying ionospheric variability driven by space weather and meteorological sources at different time scales. Analyzing data from IGS/MGEX receivers we present geostationary TEC response on X-class Solar flares of current cycle, moderate and strong geomagnetic storms, including G4 St. Patrick's day Storm 2015 and recent G3 storm of the end of May 2017. We also discuss geostationary TEC disturbances in near equatorial ionosphere caused by two SSW events (minor and major final warming of 2015-2016 winter season) as well as geostationary TEC response on typhoons activity near Taiwan in autumn 2016. Our results show large potential of geostationary TEC estimations with GNSS and SBAS signals for continuous ionospheric monitoring.

  14. Measurement of total electron content of midlatitude ionosphere and protonosphere via Faraday rotation and group relay techniques using transmission from geostationary satellites ATS-3 and ATS-6

    Science.gov (United States)

    Paul, M. P.

    1982-01-01

    Measurement of integrated columnar electron content and total electron content for the local ionosphere and the overlying protonosphere via Faraday rotation and group delay techniques has proven very useful. A field station was established having the geographic location of 31.5 deg N latitude and 91.06 deg W longitude to accomplish these objectives. A polarimeter receiving system was set up in the beginning to measure the Faraday rotation of 137.35 MHz radio signal from geostationary satellite ATS 3 to yield the integrated columnar electron content of the local ionosphere. The measurement was continued regularly, and the analysis of the data thus collected provided a synopsis of the statistical variation of the ionosphere along with the transient variations that occurred during the periods of geomagnetic and other disturbances.

  15. Multifractal analysis of vertical total electron content (VTEC at equatorial region and low latitude, during low solar activity

    Directory of Open Access Journals (Sweden)

    M. J. A. Bolzan

    2013-01-01

    Full Text Available This paper analyses the multifractal aspects of the GPS data (measured during a period of low solar activity obtained from two Brazilian stations: Belém (01.3° S, 48.3° W and São José dos Campos (SJC (23.2° S, 45.9° W. The results show that the respective geographic sites show important scaling differences as well as similarities when their multifractal signatures for vertical total electron content (VTEC are compared. The f(α spectra have a narrow shape for great scales, which indicates the predominance of deterministic phenomena, such as solar rotation (27 days over intermittent phenomena. Furthermore, the f(α spectra for both sites have a strong multifractality degree at small scales. This strong multifractality degree observed at small scales (1 to 12 h at both sites is because the ionosphere over Brazil is a non-equilibrium system. The differences found were that Belém presented a stronger multifractality at small scales (1 h to 12 h compared with SJC, particularly in 2006. The reason for this behaviour may be associated with the location of Belém, near the geomagnetic equator, where at this location the actions of X-rays, ultraviolet, and another wavelength from the Sun are more direct, strong, and constant throughout the whole year. Although the SJC site is near ionospheric equatorial anomaly (IEA peaks, this interpretation could explain the higher values found for the intermittent parameter μ for Belém compared with SJC. Belém also showed the presence of one or two flattening regions for f(α spectra at the same scales mentioned before. These differences and similarities also were interpreted in terms of the IEA content, where this phenomenon is an important source of intermittence due the presence of the VTEC peaks at ±20° geomagnetic latitudes.

  16. Impact of mode of display and message content of responsible gambling signs for electronic gaming machines on regular gamblers.

    Science.gov (United States)

    Monaghan, Sally; Blaszczynski, Alex

    2010-03-01

    Harm-minimization strategies aim to reduce gambling-related risks; however, minimal evidence supports the effectiveness of current strategies involving the placement of warning signs in gambling venues and on electronic gaming machines (EGMs). This qualitative replication study evaluated the differential effect of pop-up messages compared to static signs and the content of messages on EGMs on recall, thoughts, and behaviors assessed during the session and at 2-week follow-up. In Study 1, 127 regular EGM gamblers (male = 97, mean age = 20.3) recruited from a university student population attended a laboratory where they were randomly assigned to play a computer-based simulated EGM analogue displaying signs that differed by (a) mode of presentation (pop-up and static) and (b) message content (informative, self-appraisal, and control/blank). In Study 2, an identical methodology was used but included the use of a simulated EGM within an in vivo gaming setting with 124 regular EGM players (male = 81, mean age = 44.1). Results from both studies showed that pop-up messages were recalled more effectively than static messages immediately and at 2-week follow-up. Pop-up messages reportedly had a significantly greater impact on within-session thoughts and behaviors. Messages encouraging self-appraisal resulted in significantly greater effect on self-reported thoughts and behaviors during both the experimental session and in subsequent EGM play. These findings support the effectiveness of pop-up messages containing self-appraisal messages as an appropriate harm-minimization initiative.

  17. Cryo-scanning electron microscopy observations of vessel content during transpiration in walnut petioles. Facts or artifacts?

    Science.gov (United States)

    Cochard, H; Bodet, C; Améglio, T; Cruiziat, P

    2000-11-01

    The current controversy about the "cohesion-tension" of water ascent in plants arises from the recent cryo-scanning electron microscopy (cryo-SEM) observations of xylem vessels content by Canny and coworkers (1995). On the basis of these observations it has been claimed that vessels were emptying and refilling during active transpiration in direct contradiction to the previous theory. In this study we compared the cryo-SEM data with the standard hydraulic approach on walnut (Juglans regia) petioles. The results of the two techniques were in clear conflict and could not both be right. Cryo-SEM observations of walnut petioles frozen intact on the tree in a bath of liquid nitrogen (LN(2)) suggested that vessel cavitation was occurring and reversing itself on a diurnal basis. Up to 30% of the vessels were embolized at midday. In contrast, the percentage of loss of hydraulic conductance (PLC) of excised petiole segments remained close to 0% throughout the day. To find out which technique was erroneous we first analyzed the possibility that PLC values were rapidly returned to zero when the xylem pressures were released. We used the centrifugal force to measure the xylem conductance of petiole segments exposed to very negative pressures and established the relevance of this technique. We then analyzed the possibility that vessels were becoming partially air-filled when exposed to LN(2). Cryo-SEM observations of petiole segments frozen shortly after their xylem pressure was returned to atmospheric values agreed entirely with the PLC values. We confirmed, with water-filled capillary tubes exposed to a large centrifugal force, that it was not possible to freeze intact their content with LN(2). We concluded that partially air-filled conduits were artifacts of the cryo-SEM technique in our study. We believe that the cryo-SEM observations published recently should probably be reconsidered in the light of our results before they may be used as arguments against the cohesion

  18. Thermodynamic Analysis of TEG-TEC Device Including Influence of Thomson Effect

    Science.gov (United States)

    Feng, Yuanli; Chen, Lingen; Meng, Fankai; Sun, Fengrui

    2018-01-01

    A thermodynamic model of a thermoelectric cooler driven by thermoelectric generator (TEG-TEC) device is established considering Thomson effect. The performance is analyzed and optimized using numerical calculation based on non-equilibrium thermodynamic theory. The influence characteristics of Thomson effect on the optimal performance and variable selection are investigated by comparing the condition with and without Thomson effect. The results show that Thomson effect degrades the performance of TEG-TEC device, it decreases the cooling capacity by 27 %, decreases the coefficient of performance (COP) by 19 %, decreases the maximum cooling temperature difference by 11 % when the ratio of thermoelectric elements number is 0.6, the cold junction temperature of thermoelectric cooler (TEC) is 285 K and the hot junction temperature of thermoelectric generator (TEG) is 450 K. Thomson effect degrades the optimal performance of TEG-TEC device, it decreases the maximum cooling capacity by 28 % and decreases the maximum COP by 28 % under the same junction temperatures. Thomson effect narrows the optimal variable range and optimal working range. In the design of the devices, limited-number thermoelectric elements should be more allocated appropriately to TEG when consider Thomson effect. The results may provide some guidelines for the design of TEG-TEC devices.

  19. The Tec family kinase Itk exists as a folded monomer in vivo.

    Science.gov (United States)

    Qi, Qian; August, Avery

    2009-10-23

    Tec family tyrosine kinases transduce signals from antigen and other receptors. In particular, Itk plays an important role in T-cell development and activation. Itk has an N-terminal pleckstrin homology domain, a Tec Homology domain with a proline-rich region, SH3 and SH2 domains and a kinase domain, the structure each of which has been determined. However, the full structure of Itk and other Tec kinases remain elusive. Models of Itk suggest either a head to tail dimer, with the SH2 domain interacting with the SH3 domain, or a folded monomer with the SH3 domain interacting with the proline-rich region. We show here that in vivo Itk exists as a monomer, with the pleckstrin homology domain less than 80 A from the C terminus. Zn2+ coordinating residues in the Tec Homology domain, not the proline-rich region, are critical for this intramolecular interaction. These data have implications for our understanding of Tec family kinase structure.

  20. Analysis of ionospheric vertical total electron content before the 1 April 2014 Mw 8.2 Chile earthquake

    Science.gov (United States)

    Jiang, Weiping; Ma, Yifang; Zhou, Xiaohui; Li, Zhao; An, Xiangdong; Wang, Kaihua

    2017-11-01

    This paper studies ionospheric vertical total electron content (VTEC) variations before the 1 April 2014 Mw 8.2 Chile earthquake. VTEC derived from 14 global positioning system (GPS) stations and global ionospheric map (GIM) were used to analyze ionospheric variations before the earthquake using the sliding interquartile range method, and the results showed that significant positive VTEC anomalies occurred on 28 March. To explore possible causes of these anomalies, effects of solar and geomagnetic activities were examined, and VTEC variations during 17 March to 31 March in 2009-2013 were cross-compared. Also, VTEC for a full year before the earthquake was investigated. The results indicated that the anomalies were weakly associated with high solar activities and geomagnetic storms and that the anomalies were not normal seasonal and diurnal variations. An analysis of the spatial distribution of the observed anomalies was also presented, and it demonstrated that the anomalies specifically appeared around the epicenter on 28 March. We suggest that the observed anomalies may be associated with the subsequent Chile earthquake. Equatorial anomaly variations were analyzed to discuss the possible physical mechanism, and results showed that the equatorial anomaly unusually increased on 28 March, which indicates that anomalous electric fields generated in the earthquake preparation area and the meridional wind are possible causes of the observed ionospheric anomalies.

  1. Towards a Traceability System Based on RFID Technology to Check the Content of Pallets within Electronic Devices Supply Chain

    Directory of Open Access Journals (Sweden)

    Ignacio Angulo

    2013-01-01

    Full Text Available In the last few years there has been a growing interest in smart solutions capable of dealing with the traceability of products and materials to improve logistical processes. Most of the existing solutions have been designed without considering the difficulties of deploying traceability systems in the storehouses currently working, not dealing with specific needs, such as environment characteristics or time required to be handled by workers. In this paper, in order to test the viability of its application, a first prototype of a traceability system capable of checking the content of pallets loaded with electronic devices is presented. It is based on ultra-high frequency (UHF radio frequency identification (RFID technology using passive tags. A holistic approach has been adopted to design the system: it begins with a radioelectrical characterization of the environment where the check points will be implemented, continues with the integration of a set of data acquisition and wireless communication devices, and ends with a logistics information system able to provide final user services. The combination of physical layer analysis with a top layer system view can aid the planning as well as operational phase of this type of RFID system within a logistic chain.

  2. Electron number density profiles derived from radio occultation on the CASSIOPE spacecraft

    DEFF Research Database (Denmark)

    Shume, E. B.; Vergados, P.; Komjathy, A.

    2017-01-01

    This paper presents electron number density profiles derived from high resolution Global Positioning System (GPS) radio occultation (RO) observations performed using the Enhanced Polar Outflow Probe (e-POP) payload on the high inclination CAScade, Smallsat and IOnospheric Polar Explorer (CASSIOPE......) spacecraft. We have developed and applied a novel inverse Abel transform algorithm on high rate RO total electron content (TEC) measurements performed along GPS to CASSIOPE radio links to recover electron density profiles. The high resolution density profiles inferred from the CASSIOPE RO are: (1) in very...... number density profiles retrieved over landmasses and oceans. The density profiles over oceans exhibit wide-spread values and scale heights compared to density profiles over landmasses. We provide an explanation for the ocean-landmass discrepancy in terms of the unique wave coupling mechanisms operating...

  3. DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.

    Directory of Open Access Journals (Sweden)

    Masako Osada

    2010-02-01

    Full Text Available Thymic epithelial cell (TEC microenvironments are essential for the recruitment of T cell precursors from the bone marrow, as well as the subsequent expansion and selection of thymocytes resulting in a mature self-tolerant T cell repertoire. The molecular mechanisms, which control both the initial development and subsequent maintenance of these critical microenvironments, are poorly defined. Wnt signaling has been shown to be important to the development of several epithelial tissues and organs. Regulation of Wnt signaling has also been shown to impact both early thymocyte and thymic epithelial development. However, early blocks in thymic organogenesis or death of the mice have prevented analysis of a role of canonical Wnt signaling in the maintenance of TECs in the postnatal thymus.Here we demonstrate that tetracycline-regulated expression of the canonical Wnt inhibitor DKK1 in TECs localized in both the cortex and medulla of adult mice, results in rapid thymic degeneration characterized by a loss of DeltaNP63(+ Foxn1(+ and Aire(+ TECs, loss of K5K8DP TECs thought to represent or contain an immature TEC progenitor, decreased TEC proliferation and the development of cystic structures, similar to an aged thymus. Removal of DKK1 from DKK1-involuted mice results in full recovery, suggesting that canonical Wnt signaling is required for the differentiation or proliferation of TEC populations needed for maintenance of properly organized adult thymic epithelial microenvironments.Taken together, the results of this study demonstrate that canonical Wnt signaling within TECs is required for the maintenance of epithelial microenvironments in the postnatal thymus, possibly through effects on TEC progenitor/stem cell populations. Downstream targets of Wnt signaling, which are responsible for maintenance of these TEC progenitors may provide useful targets for therapies aimed at counteracting age associated thymic involution or the premature thymic

  4. DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.

    Science.gov (United States)

    Osada, Masako; Jardine, Logan; Misir, Ruth; Andl, Thomas; Millar, Sarah E; Pezzano, Mark

    2010-02-08

    Thymic epithelial cell (TEC) microenvironments are essential for the recruitment of T cell precursors from the bone marrow, as well as the subsequent expansion and selection of thymocytes resulting in a mature self-tolerant T cell repertoire. The molecular mechanisms, which control both the initial development and subsequent maintenance of these critical microenvironments, are poorly defined. Wnt signaling has been shown to be important to the development of several epithelial tissues and organs. Regulation of Wnt signaling has also been shown to impact both early thymocyte and thymic epithelial development. However, early blocks in thymic organogenesis or death of the mice have prevented analysis of a role of canonical Wnt signaling in the maintenance of TECs in the postnatal thymus. Here we demonstrate that tetracycline-regulated expression of the canonical Wnt inhibitor DKK1 in TECs localized in both the cortex and medulla of adult mice, results in rapid thymic degeneration characterized by a loss of DeltaNP63(+) Foxn1(+) and Aire(+) TECs, loss of K5K8DP TECs thought to represent or contain an immature TEC progenitor, decreased TEC proliferation and the development of cystic structures, similar to an aged thymus. Removal of DKK1 from DKK1-involuted mice results in full recovery, suggesting that canonical Wnt signaling is required for the differentiation or proliferation of TEC populations needed for maintenance of properly organized adult thymic epithelial microenvironments. Taken together, the results of this study demonstrate that canonical Wnt signaling within TECs is required for the maintenance of epithelial microenvironments in the postnatal thymus, possibly through effects on TEC progenitor/stem cell populations. Downstream targets of Wnt signaling, which are responsible for maintenance of these TEC progenitors may provide useful targets for therapies aimed at counteracting age associated thymic involution or the premature thymic degeneration associated

  5. Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.

    Science.gov (United States)

    Jongstra-Bilen, Jenny; Puig Cano, Adrianet; Hasija, Manvi; Xiao, Haiyan; Smith, C I Edvard; Cybulsky, Myron I

    2008-07-01

    Tec family nonreceptor tyrosine kinases are expressed by hematopoietic cells, activate phospholipase C (PLC)gamma, and regulate cytoskeletal rearrangement, yet their role in FcgammaR-induced signaling and phagocytosis remains unknown. We demonstrate in this study that Bruton's tyrosine kinase (Btk) and Tec, the only Tec kinases expressed by RAW 264.7 cells, are activated throughout phagocytosis. Activated Btk and Tec kinase accumulate at an early stage at the base of phagocytic cups and inhibition of their activity by the specific inhibitor LFM-A13 or expression by small interfering RNA significantly inhibited FcgammaR-induced phagocytosis. Similarly, a significant role for these kinases in phagocytosis was found in primary macrophages. FcgammaR-induced activation of Mac-1, which is required for optimal phagocytosis, was markedly inhibited and our findings suggest that the roles of kinases Btk and Tec in Mac-1 activation account for their functions in the early stages of phagocytosis. Initial activation of PLCgamma2, the predominant PLC isoform in RAW 264.7 cells, is dependent on Syk. In contrast, a late and prolonged activation of PLCgamma2 was dependent on Btk and Tec. We found accumulation of diacylglycerol (DAG), a PLCgamma product, in phagosome membranes, and activated Btk, but not Tec, colocalized with phagosomal DAG. Inhibition of Tec family kinase activity increased the level of DAG in phagosomes, suggesting a negative regulatory role for Btk. Tec, in contrast, clustered at sites near phagosome formation. In summary, we elucidated that Tec family kinases participate in at least two stages of FcgammaR-mediated phagocytosis: activation of Mac-1 during ingestion, and after phagosome formation, during which Btk and Tec potentially have distinct roles.

  6. Comprehensive human resources development program for nuclear power at NuTEC/JAEA

    International Nuclear Information System (INIS)

    Ishimura, T.

    2010-03-01

    Nuclear Technology and Education Center (NuTEC) of the Japan Atomic Energy Agency (JAEA) aims at comprehensive nuclear education and training activities, which cover 1) education and training for national nuclear engineers, 2) cooperation with universities and 3) international contribution and cooperation. The main feature of NuTEC's training programs is that the curricula place emphasis on the laboratory exercises with well-equipped training facilities, including research reacotrs, and expertise of lecturers mostly from JAEA. The wide spectrum of cooperative activities have been pursued with universities and also with international organizations, such as IAEA, ENEN, CEA/INSTN and FNCA countries. The present paper descrives the overall HRD activities of NuTEC, especially in nuclear power field. (author)

  7. [Effects of CD74 gene on IFNγR gene expression in MG TEC].

    Science.gov (United States)

    Li, Qian-Ru; Zang, Wen-Qiao; Gao, Feng; Du, Ying; Zhang, Qing-Yong

    2011-07-01

    To study the effects of CD74 gene on IFN-γR expression in myasthenia gravis thymic epithelial cell(TEC). PCMV-CD74 transiently transfect to primary cultured TEC mediated with lipofectamine, the result of transfection and some autoimmune related genes such as IFN-γR were detected by real-time RT-PCR. Real-time quantitative RT-PCR results show that the mRNA expression level of IL-4R, IL-32, IFN-γR, ECGF1, HLA-A, HLA-DR increased significantly, with the high express ion of CD74 gene in thymic epithelial cells. CD74 gene over-expression in TEC can increase IFN-γR mRNA expression.

  8. Efficacy of TCH/TEC neoadjuvant chemotherapy for the treatment of HER-2-overexpressing breast cancer.

    Science.gov (United States)

    Chen, Weicai; He, Jinsong; Song, Shufen; Wang, Min; Wu, Huisheng; Wang, Xianming

    2015-04-01

    The aim of the present study was to observe the efficacy of neoadjuvant trastuzumab combined with docetaxel and carboplatin (TCH), and docetaxel, epirubicin and cyclophosphamide (TEC) chemotherapy in human epidermal growth factor receptor-2 (HER-2)-overexpressing breast cancer. The total cohort of 64 cases of HER-2-overexpressing breast cancer patients was divided into two groups according to their treatment preferences: The TCH group, consisting of 39 patients, and the TEC group, consisting of 25 patients. The neoadjuvant chemotherapy was continued for six cycles prior to comparison of the treatment efficacy. The TCG and TEC groups exhibited an overall response rate of 94.9 and 72.0% (37/39 and 18/25 cases; PTEC-treated group.

  9. The theory of event coding (TEC) as embodied-cognition framework.

    Science.gov (United States)

    Hommel, Bernhard

    2015-01-01

    The concept of embodied cognition attracts enormous interest but neither is the concept particularly well-defined nor is the related research guided by systematic theorizing. To improve this situation the theory of event coding (TEC) is suggested as a suitable theoretical framework for theorizing about cognitive embodiment-which, however, presupposes giving up the anti-cognitivistic attitude inherent in many embodiment approaches. The article discusses the embodiment-related potential of TEC, and the way and degree to which it addresses Wilson's (2002) six meanings of the embodiment concept. In particular, it is discussed how TEC considers human cognition to be situated, distributed, and body-based, how it deals with time pressure, how it delegates work to the environment, and in which sense it subserves action.

  10. The Src, Syk, and Tec family kinases: distinct types of molecular switches.

    Science.gov (United States)

    Bradshaw, J Michael

    2010-08-01

    The Src, Syk, and Tec family kinases are three of the most well characterized tyrosine kinase families found in the human genome. Members of these kinase families function downstream of antigen and F(c) receptors in hematopoietic cells and transduce signals leading to calcium mobilization, altered gene expression, cytokine production, and cell proliferation. Over the last several years, structural and biochemical studies have begun to uncover the molecular mechanisms regulating activation of these kinases. It appears that each kinase family functions as a distinct type of molecular switch. This review discusses the activation of the Src, Syk, and Tec kinases from the perspective of structure, phosphorylation, allosteric regulation, and kinetics. The multiple factors that regulate the Src, Syk, and Tec families illustrate the important role played by each of these kinases in immune cell signaling.

  11. Scintillations and TEC gradients from Europe to Africa: a picture by the MISW project

    DEFF Research Database (Denmark)

    Alfonsi, Lucilla; Spogli, Luca; Cesaroni, Claudio

    2016-01-01

    MISW (Mitigation of space weather threats to GNSS services) is an EU/FP7 project with the purpose of tacklingthe research challenges associated with Space Weather effects on GNSS (Global Navigation Satellite System).In particular, the objective of MISW is to develop suitable algorithms capable...... of enabling Satellite BasedAugmentation Systems (e.g. EGNOS) in the low-latitude African sector. For this purpose, MISW has created adetailed picture of extreme space weather events that occurred in the past and in the current solar cycle. Despiteits weakness, the current solar cycle exhibited two superstorms...... of calibrated TEC and TEC gradients with the scintillation data. The impact of the storm on GNSSperformance has also been investigated in terms of losses of lock.The results of this study highlight the importance of assessing the latitudinal and the longitudinal TEC gradientsas crucial information to identify...

  12. Using GPS TEC measurements to probe ionospheric spatial spectra at mid-latitudes

    Science.gov (United States)

    Lay, E. H.; Parker, P. A.; Light, M. E.; Carrano, C. S.; Debchoudhury, S.; Haaser, R. A.

    2017-12-01

    The physics of how random ionospheric structure causes signal degradation is well understood as weak forward scattering through an effective diffraction grating created by plasma irregularities in the ionosphere. However, the spatial scale spectrum of those irregularities required for input into scintillation models and models of traveling ionospheric disturbances is poorly characterized, particularly at the kilometer to tens of kilometer scale lengths important for very-high-frequency (VHF) scintillation prediction. Furthermore, the majority of characterization studies have been performed in low-latitude or high-latitude regions where geomagnetic activity dominates the physical processes. At mid-latitudes, tropospheric and geomagnetic phenomena compete in disturbing the ionosphere, and it is not well understood how these multiple sources affect the drivers that influence the spatial spectrum. In this study, we are interested in mid-latitude electron density irregularities on the order of 10s of kilometers that would affect VHF signals. Data from the GPS networks Japan GEONET and the Plate Boundary Observatory (PBO, UNAVCO) in the western United States were analyzed for this study. Japan GEONET is a dense network of GPS receivers (station spacing of tens of km), with fairly evenly spaced positions over all of Japan. The PBO, on the other hand, has several pockets of extremely dense coverage (station spacing within a few km), but is less dense on average. We analyze a day with a large solar storm (2015/03/17, St. Patrick's Day Storm) to allow high scintillation potential at mid-latitudes, a day with low geomagnetic activity and low thunderstorm activity (2016/01/31), and a day with low geomagnetic activity and high thunderstorm activity (2015/08/02). We then perform two-dimensional spatial analyses on the TEC data from these two networks on scale lengths of 20 to 200 km to infer the spatial scale spectra.

  13. Face-to-face and electronic communications in maintaining social networks : the influence of geographical and relational distance and of information content

    NARCIS (Netherlands)

    Tillema, Taede; Dijst, Martin; Schwanen, Tim

    Using data collected among 742 respondents, this article aims at gaining greater insight into (i) the interaction between face-to-face (F2F) and electronic contacts, (ii) the influence of information content and relational distance on the communication mode/service choice and (iii) the influence of

  14. 78 FR 55250 - TEC Energy Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

    Science.gov (United States)

    2013-09-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2304-000] TEC Energy Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of TEC Energy Inc...

  15. 75 FR 11939 - Arkansas Lamp Manufacturing, Including On-Site Leased Workers From TEC, Van Buren, AR; Notice of...

    Science.gov (United States)

    2010-03-12

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-71,714] Arkansas Lamp Manufacturing, Including On-Site Leased Workers From TEC, Van Buren, AR; Notice of Termination of Investigation... Manufacturing, Van Buren, Arkansas. The worker group includes on-site leased workers from TEC. The petitioner...

  16. Reception Test of Petals for the End Cap TEC+ of the CMS Silicon Strip Tracker

    CERN Document Server

    Bremer, R; Klein, Katja; Schmitz, Stefan Antonius; Adler, Volker; Adolphi, Roman; Ageron, Michel; Agram, Jean-Laurent; Atz, Bernd; Barvich, Tobias; Baulieu, Guillaume; Beaumont, Willem; Beissel, Franz; Bergauer, Thomas; Berst, Jean-Daniel; Blüm, Peter; Bock, E; Bogelsbacher, F; de Boer, Wim; Bonnet, Jean-Luc; Bonnevaux, Alain; Boudoul, Gaelle; Bouhali, Othmane; Braunschweig, Wolfgang; Brom, Jean-Marie; Butz, Erik; Chabanat, Eric; Chabert, Eric Christian; Clerbaux, Barbara; Contardo, Didier; De Callatay, Bernard; Dehm, Philip; Delaere, Christophe; Della Negra, Rodolphe; Dewulf, Jean-Paul; D'Hondt, Jorgen; Didierjean, Francois; Dierlamm, Alexander; Dirkes, Guido; Dragicevic, Marko; Drouhin, Frédéric; Ernenwein, Jean-Pierre; Esser, Hans; Estre, Nicolas; Fahrer, Manuel; Fernández, J; Florins, Benoit; Flossdorf, Alexander; Flucke, Gero; Flügge, Günter; Fontaine, Jean-Charles; Freudenreich, Klaus; Frey, Martin; Friedl, Markus; Furgeri, Alexander; Giraud, Noël; Goerlach, Ulrich; Goorens, Robert; Graehling, Philippe; Grégoire, Ghislain; Gregoriev, E; Gross, Laurent; Hansel, S; Haroutunian, Roger; Hartmann, Frank; Heier, Stefan; Hermanns, Thomas; Heydhausen, Dirk; Heyninck, Jan; Hosselet, J; Hrubec, Josef; Jahn, Dieter; Juillot, Pierre; Kaminski, Jochen; Karpinski, Waclaw; Kaussen, Gordon; Keutgen, Thomas; Klanner, Robert; König, Stefan; Kosbow, M; Krammer, Manfred; Ledermann, Bernhard; Lemaître, Vincent; De Lentdecker, Gilles; Linn, Alexander; Lounis, Abdenour; Lübelsmeyer, Klaus; Lumb, Nicholas; Maazouzi, Chaker; Mahmoud, Tariq; Michotte, Daniel; Militaru, Otilia; Mirabito, Laurent; Müller, Thomas; Neukermans, Lionel; Ollivetto, C; Olzem, Jan; Ostapchuk, Andrey; Pandoulas, Demetrios; Pein, Uwe; Pernicka, Manfred; Perriès, Stephane; Piaseki, C; Pierschel, Gerhard; Piotrzkowski, Krzysztof; Poettgens, Michael; Pooth, Oliver; Rouby, Xavier; Sabellek, Andreas; Schael, Stefan; Schirm, Norbert; Schleper, Peter; Schultz von Dratzig, Arndt; Siedling, Rolf; Simonis, Hans-Jürgen; Stahl, Achim; Steck, Pia; Steinbruck, G; Stoye, Markus; Strub, Roger; Tavernier, Stefaan; Teyssier, Daniel; Theel, Andreas; Trocmé, Benjamin; Udo, Fred; Van der Donckt, M; Van der Velde, C; Van Hove, Pierre; Vanlaer, Pascal; Van Lancker, Luc; Van Staa, Rolf; Vanzetto, Sylvain; Weber, Markus; Weiler, Thomas; Weseler, Siegfried; Wickens, John; Wittmer, Bruno; Wlochal, Michael; De Wolf, Eddi A; Zhukov, Valery; Zoeller, Marc Henning

    2009-01-01

    The silicon strip tracker of the CMS experiment has been completed and was inserted into the CMS detector in late 2007. The largest sub system of the tracker are its end caps, comprising two large end caps (TEC) each containing 3200 silicon strip modules. To ease construction, the end caps feature a modular design: groups of about 20 silicon modules are placed on sub-assemblies called petals and these self-contained elements are then mounted onto the TEC support structures. Each end cap consists of 144 such petals, which were built and fully qualified by several institutes across Europe. From

  17. Variability of Total Electron Content at Low Latitude Region During Solar Minimum 2008: Impact of High Speed Streams, HSSs

    Science.gov (United States)

    Nicoli Candido, C. M.; Batista, I. S.; Becker-Guedes, F.; Klausner, V.

    2015-12-01

    The solar minimum period of solar cycle 23 was unusually long and quiet in comparison to other solar minima in last century. Several reports have analyzed its features and its impact under diverse points-of-view. In this work, we analyze the low latitude ionosphere behavior in Brazil and its response during this peculiar period. The ionospheric variation is analyzed through typical parameters such as vertical total electron content (VTEC), the peak height of F2 layer and its critical frequency, hmF2 and foF2, in 2008, around the southern crest of the Equatorial Ionization Anomaly (EIA), in Cachoeira Paulista (22.5o S, 45.0 o W, mag. lat: 16 o S, dip angle: -32.3o) and at an equatorial station, São Luís (2.33o S, 44.2o W, dip angle: -6.7o). VTEC values present a semiannual variation pattern and two well-defined peaks in March and October. Daily maximum values are observed around 15:00 LT. It was observed periodicities observed of 9, 13.5 and 27 days in VTEC and hmF2, mainly at the first and the second half of 2008. These periods match with the observed periods in solar and geomagnetic indexes such as Vsw, Kp and AE and are associated with occurrence of high speed streams (HSS) coming from solar coronal holes. A complex response of the low latitude ionosphere is observed, with prominent increases and decreases of VTEC at daytime during the interval of occurrence of HSSs. It is suggested that a combination of several factors such as prompt penetration of electric field, disturbed dynamo electric field, meridional winds, thermal expansion of thermosphere and composition changes of neutral atmosphere are responsible for the high day-to-day variability of the ionosphere

  18. Comparison of a low and a middle latitude GPS-TEC in Africa during ...

    African Journals Online (AJOL)

    In this work, we compared TEC values at Libreville (a low latitude station) with Sutherland (a middle latitude station) over Africa using Global Positioning System (GPS) receivers during high solar activity (HSA), moderate solar activity (MSA) and low solar activity (LSA). Apart from our confirmation that high, moderate and low ...

  19. TecCOMFrame : Building bridges between technical communication and translation studies through a prototype specialisation curriculum

    NARCIS (Netherlands)

    Cleary, Yvonne; Engberg, Jan; Karreman, Joyce; Meex, Birgitta; Closs, Sissi; Drazek, Zygmunt; Ghenghea, Voichita; Minacori, Patricia; Muller, J.; Straub, Daniela

    2017-01-01

    Technical communication is a new field of work compared to other professions, and therefore it does not have a standardised curriculum. In Europe, many technical communicators do not have qualifications in the area. TecCOMFrame, a project funded by the European Union, aims to develop an academic

  20. The cooling control system for focal plane assembly of astronomical satellite camera based on TEC

    Science.gov (United States)

    He, Yuqing; Du, Yunfei; Gao, Wei; Li, Baopeng; Fan, Xuewu; Yang, Wengang

    2017-02-01

    The dark current noise existing in the CCD of the astronomical observation camera has a serious influence on its working performance, reducing the working temperature of CCD can suppress the influence of dark current effectively. By analyzing the relationship between the CCD chip and the dark current noise, the optimum working temperature of the red band CCD focal plane is identified as -75°. According to the refrigeration temperature, a cooling control system for focal plane based on a thermoelectric cooler (TEC) was designed. It is required that the system can achieve high precision temperature control for the target. In the cooling control system, the 80C32 microcontroller was used as its systematic core processor. The advanced PID control algorithm is adopted to control the temperature of the top end of TEC. The bottom end of the TEC setting a constant value according to the target temperature used to assist the upper TEC to control the temperature. The experimental results show that the cooling system satisfies the requirements of the focal plane for the astronomical observation camera, it can reach the working temperature of -75° and the accuracy of ±2°.

  1. 76 FR 73683 - Whirlpool Corporation, Including On-Site Leased Workers From Career Solutions TEC Staffing...

    Science.gov (United States)

    2011-11-29

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,593] Whirlpool Corporation, Including On-Site Leased Workers From Career Solutions TEC Staffing, Andrews International, IBM Corporation... refrigerators and trash compactors. The notice was published in the Federal Register on October 25, 2010 (75 FR...

  2. 76 FR 72978 - Whirlpool Corporation Including On-Site Leased Workers From Career Solutions TEC Staffing...

    Science.gov (United States)

    2011-11-28

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,593] Whirlpool Corporation Including On-Site Leased Workers From Career Solutions TEC Staffing, Andrews International, IBM Corporation... workers are engaged in the production of refrigerators and trash compactors. The notice was published in...

  3. Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion.

    Science.gov (United States)

    Ebert, Antje D; Laussmann, Mareike; Wegehingel, Sabine; Kaderali, Lars; Erfle, Holger; Reichert, Jürgen; Lechner, Johannes; Beer, Hans-Dietmar; Pepperkok, Rainer; Nickel, Walter

    2010-06-01

    Fibroblast growth factor 2 (FGF2) is a potent mitogen that is exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes, a process that depends on the phosphoinositide phosphatidylinositol 4,5-biphosphate (PI(4,5)P(2)) at the inner leaflet as well as heparan sulfate proteoglycans at the outer leaflet of plasma membranes; however, additional core and regulatory components of the FGF2 export machinery have remained elusive. Here, using a highly effective RNAi screening approach, we discovered Tec kinase as a novel factor involved in unconventional secretion of FGF2. Tec kinase does not affect FGF2 secretion by an indirect mechanism, but rather forms a heterodimeric complex with FGF2 resulting in phosphorylation of FGF2 at tyrosine 82, a post-translational modification shown to be essential for FGF2 membrane translocation to cell surfaces. Our findings suggest a crucial role for Tec kinase in regulating FGF2 secretion under various physiological conditions and, therefore, provide a new perspective for the development of a novel class of antiangiogenic drugs targeting the formation of the FGF2/Tec complex.

  4. Measuring Ionospheric Irregularities Globally by the Rate of TEC Index and GNSS Networks

    Science.gov (United States)

    Pi, Xiaoqing

    2012-01-01

    Outline of presentation: Why do we use the rate of TEC index (ROTI) instead of the standard s4 and sigma-phi indices? What are the differences between S4, sigma-phi and ROTI? Examples of ROTI measurements and Development status and plan.

  5. Comparison of Doctors' and Breast Cancer Patients' Perceptions of Docetaxel, Epirubicin, and Cyclophosphamide (TEC) Toxicity.

    Science.gov (United States)

    Bayo, Juan; Prieto, Blanca; Rivera, Francisco

    2016-05-01

    In Spain, around 26,000 cases of breast cancer are diagnosed each year, representing nearly 30% of all cancers in women. The aim this study was to compare the perceptions of nonhematologic toxicities after administration of a docetaxel, epirubicin, and cyclophosphamide (TEC) regimen between breast cancer patients and oncologists. Furthermore, the relationship between such adverse events and quality of life (QOL) was evaluated. Cross-sectional study carried out among 92 breast cancer patients who received TEC as neoadjuvant or adjuvant treatment. The main nonhematologic toxicities experienced by breast cancer patients treated with the TEC regimen were asthenia, nausea, dysgeusia, arthralgia, headache, and myalgia. Patients were less likely to be affected by vomiting and peripheral neuropathy. Oncologists seemed to show greater interest in toxicities, such as asthenia, nausea, and diarrhea. Vomiting was the toxicity with the most substantial degree of agreement between oncologist and patient. Toxicities with greater disagreement were dysgeusia, arthralgia, myalgia, asthenia, and headache. Asthenia, dysgeusia, loss of appetite, skin allergies, peripheral edema, abdominal pain, and myalgia were found to significantly affect the QOL. Tolerability and QOL were more favorable in patients treated with pegfilgrastim compared with filgrastim. Oncologists tend to underestimate toxicities experienced by breast cancer patients treated with the TEC regimen. The establishment of a protocol to record these toxicities may reduce that problem. © 2016 Wiley Periodicals, Inc.

  6. Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.

    Science.gov (United States)

    Joseph, Raji E; Andreotti, Amy H

    2011-01-18

    The regulatory spine is a set of conserved residues that are assembled and disassembled upon activation and inactivation of kinases. We recently identified the regulatory spine within the immunologically important Tec family kinases and have shown that in addition to the core spine residues within the kinase domain itself, contributions from the SH2-kinase linker region result in an extended spine structure for this kinase family. Disruption of the regulatory spine, either by mutation or by removal of the amino-terminal SH2-kinase linker region or by mutation of core spine residues, leads to inactivation of the Tec kinases. With a focus on the Tec family members, Itk and Btk, we now show that the gatekeeper residue is also critical for the assembly of the regulatory spine. Mutation of the bulky Itk F434 gatekeeper residue to alanine or glycine inactivates Itk. The activity of the Itk F434A mutant can be recovered by a secondary site mutation within the N-terminal lobe, specifically L432I. The Itk L432I mutation likely rescues the activity of the gatekeeper F434A mutation by promoting the assembly of the regulatory spine. We also show that mutation of the Itk and Btk gatekeeper residues to methionine is sufficient to activate the isolated kinase domains of Tec kinases in the absence of the amino-terminal SH2-kinase linker. Thus, shifting the conformational equilibrium between the assembled and disassembled states of the regulatory spine by changing the nature of the gatekeeper residue is key to regulating the activity of Tec kinases.

  7. Efficacy of neo-adjuvant chemotherapy with TEC regimen on breast cancer.

    Science.gov (United States)

    Gu, Xi; Zhang, Yang; Chen, Long; Guo, Jiao; Zhang, Wen-Hai

    2015-02-01

    This study aims to investigate the efficacy of neo-adjuvant chemotherapy with TEC regimen (taxotere-epirubicin-cyclophosphamide) in the treatment of breast cancer (BC) patients. Total of 118 BC patients were recruited from the Department of Breast Surgery in Shengjing Hospital of China Medical University from January 1, 2010 to December 31, 2012, in this study. The clinical data and serum samples were collected from each patient prior to the study. All patients were given four cycles of TEC chemotherapy before surgery. The overall response rate of TEC regimen in the treatment of BC was 67.8% (80/118), clinical complete response rate was 3.4% (4/118), and clinical partial response rate was 64.4% (76/118). Furthermore, we found that age, tumor size, lymph node metastasis and clinical stages of patients had no statistically significant difference (all P > 0.05). Both negative ER status and negative PR status were statistically related to better response (P = 0.033 and P = 0.024, respectively) when compared with the positive ER status and positive PR status, while such association was not observed between the negative HER-2 status and positive HER-2 status (P > 0.05). In addition, the efficacy of triple-negative breast cancer was significantly better than that of luminal A, luminal B and HER-2+ cancers (all P 0.05). Our study support the view that BC cases under the TEC chemotherapy were related to higher overall response rates; and the chemotherapy with the TEC regimen could be served as an effective therapy in the treatment of BC.

  8. The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset.

    Science.gov (United States)

    Boucheron, Nicole; Sharif, Omar; Schebesta, Alexandra; Croxford, Andrew; Raberger, Julia; Schmidt, Uwe; Vigl, Benjamin; Bauer, Jan; Bankoti, Rashmi; Lassmann, Hans; Epstein, Michelle M; Knapp, Sylvia; Waisman, Ari; Ellmeier, Wilfried

    2010-11-01

    The generation of Th17 cells has to be tightly controlled during an immune response. In this study, we report an increase in a CD44(high)CD62L(-) Th17 subset in mice deficient for the protein tyrosine kinase Tec. CD44(high)CD62L(-) Tec(-/-) CD4(+) T cells produced enhanced IL-17 upon activation, showed increased expression levels of IL-23R and RORγt, and IL-23-mediated expansion of Tec(-/-) CD4(+) T cells led to an increased production of IL-17. Tec(-/-) mice immunized with heat-killed Streptococcus pneumoniae displayed increased IL-17 expression levels in the lung postinfection with S. pneumoniae, and this correlated with enhanced pneumococcal clearance and reduced lung inflammation compared with Tec(+/+) mice. Moreover, naive Tec(-/-) OT-II CD4(+) T cells produced higher levels of IL-17 when cultured with OVA peptide-loaded bone marrow-derived dendritic cells that have been previously activated with heat-killed S. pneumoniae. Taken together, our data indicated a critical role for Tec in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44(high)CD62L(-) effector/memory Th17 populations.

  9. Examining Evidence-Based Content Related to Hospital Acquired Pressure Ulcer Prevention in Paper and Electronic Health Records

    Science.gov (United States)

    Jaekel, Camilla M.

    2012-01-01

    Although there have been great advancements in the Electronic Health Record (EHR), there is a dearth of rigorous research that examines the relationship between the use of electronic documentation to capture nursing process components and the impact of consistent documentation on patient outcomes (Daly, Buckwalter & Maas, 2002; Gugerty, 2006;…

  10. ProTec Tear-Offs: A Preliminary Assessment

    International Nuclear Information System (INIS)

    Peeler, D

    2005-01-01

    result of a sludge spill or splatter), gamma radiation damage, and/or accidental scratching (due to manipulator/tool contact). The short term tests performed in this task showed that Mylar tear-offs can withstand the chemical and physical abuses expected in off-normal shielded cells operations. The ''tear-offs'' not only provide some measure of acid resistance, as reflected by the lack of visual degradation after being exposed to four acids, but also act as a protective barrier to accidental contact with the manipulators and/or tools. The conceptual ''erasing'' of scratches or marks was demonstrated in the shielded cell mock-up facility through the removal, with manipulators, of the outer layer tear-off. The successful removal of the outer layer tear-off with the manipulator, using tabs not specifically designed for remote operations, demonstrates that the system is ''manipulator-friendly'' and could be implemented in the shielded cells. The ability to remove the outer layer tear-off not only regains visual clarity but also reduces waste disposal volumes (i.e., disposal of a thin sheet of Mylar which is ''collapsible'' versus the bulk disposal of a rigid Lexan sheet or glovebox/sash window) which is more cost effective. The ''tear-off'' system could also reduce the number of cell entries needed to replace the Lexan sheet and increase the time interval between glovebox/sash window change outs which can be costly and time consuming. Although the primary focus of this report addresses the application of the Mylar tear-offs on shielded cells windows, the concept is also potentially applicable to glovebox and hood sash windows. In fact, the tear-off concept is potentially applicable to any system where visual clarity is compromised given the environmental conditions of the test. In addition, the tear-offs could be applied to walls or shelves where a protective barrier would reduce deterioration or discoloration. This concept is referred to as the ProTec(trademark) tear

  11. Ionospheric topside models compared with experimental electron density profiles

    Directory of Open Access Journals (Sweden)

    S. M. Radicella

    2005-06-01

    Full Text Available Recently an increasing number of topside electron density profiles has been made available to the scientific community on the Internet. These data are important for ionospheric modeling purposes, since the experimental information on the electron density above the ionosphere maximum of ionization is very scarce. The present work compares NeQuick and IRI models with the topside electron density profiles available in the databases of the ISIS2, IK19 and Cosmos 1809 satellites. Experimental electron content from the F2 peak up to satellite height and electron densities at fixed heights above the peak have been compared under a wide range of different conditions. The analysis performed points out the behavior of the models and the improvements needed to be assessed to have a better reproduction of the experimental results. NeQuick topside is a modified Epstein layer, with thickness parameter determined by an empirical relation. It appears that its performance is strongly affected by this parameter, indicating the need for improvements of its formulation. IRI topside is based on Booker's approach to consider two parts with constant height gradients. It appears that this formulation leads to an overestimation of the electron density in the upper part of the profiles, and overestimation of TEC.

  12. Association of patient recall, satisfaction, and adherence to content of an electronic health record (EHR)-generated after visit summary: a randomized clinical trial.

    Science.gov (United States)

    Pavlik, Valory; Brown, Anthony E; Nash, Susan; Gossey, J Travis

    2014-01-01

    Most electronic health record (EHR) systems have the capability of generating a printed after-visit summary (AVS), but there has been little research on optimal content. We conducted a qualitative study and a randomized trial to understand the effect of AVS content on patient recall and satisfaction. Adult primary care patients (n = 272) with at least 1 chronic condition were randomly assigned to 4 AVS content conditions: minimum, intermediate, maximum, or standard AVS. Demographics and health literacy were measured at an index clinic visit. Recall and satisfaction were measured by telephone 2 days and 2 to 3 weeks after the clinic visit. Average age was 52 years; 75% of patients were female, 61% were Hispanic, and 21% were African American, and 64% had adequate health literacy. Average medication recall accuracy was 53% at 2 days and 52% at 3 weeks, with no significant difference among groups at either time. Satisfaction with AVS content was high and did not differ among groups. Recall of specific content categories was low and unrelated to group assignment. Health literacy was unrelated to recall and satisfaction. Primary care patients like to receive an AVS, but the amount of information included does not affect content recall or satisfaction with the information.

  13. Association between exposure to sexually explicit content in the electronic media and sexual intentions of in-school adolescents in Southwest Nigeria.

    Science.gov (United States)

    Adeolu, Josephine; Owoaje, Eme; Olumide, Adesola

    2016-10-14

    Many adolescents are exposed to a significant amount of sexual content in the media. This has far-reaching effects on their sexual practices as this exposure is occurring at a period when most adolescents are often not sure of the choices to make, and the choices they make during adolescence affect their health when they become adults. The aim of this study was to assess the association between exposure of in-school adolescents to sexual content in the electronic media and their sexual intentions. In this cross-sectional study, information was obtained from 750 senior secondary school students in private and public schools using interviewer-administered questionnaire. Sexual media content in the movies, music video and Internet was assessed using a modified version of the sexual media diet tool. The dependent variable was sexual intention; the main independent variable was exposure to sexually explicit content in the media and confounders that were controlled for selected individual (age, sex, religiosity, self-esteem and attachment to parents), family (parents' marital status, parents' type of marriage, hands-on parenting and parent-adolescent communication on sex) and environmental factors (school connectedness and influence from peers) which were previously reported to be associated with sexual intentions of adolescents. Chi-square test was used to determine associations between sexual content of the electronic media and adolescents' sexual intentions, and confounders were controlled for using logistic regression analysis. Thirty-six percent of respondents were exposed to overtly explicit sexual content from all forms of media in the 3 months prior to this study. Twenty-four percent of the adolescents indicated their intention to have sex within 12 months following the study. Predictors of sexual intention were as follows: moderate [odds ratio, OR=2.21 (95% confidence interval, CI: 1.22-3.99)] and high exposure to sexual content in the media [OR=3.02 (95% CI: 1

  14. TecDEM: A MATLAB based toolbox for tectonic geomorphology, Part 2: Surface dynamics and basin analysis

    Science.gov (United States)

    Shahzad, Faisal; Gloaguen, Richard

    2011-02-01

    We present the analytical capability of TecDEM, a MATLAB toolbox used in conjunction with Global DEMs for the extraction of tectonic geomorphologic information. TecDEM includes a suite of algorithms to analyze topography, extracted drainage networks and sub-basins. The aim of part 2 of this paper series is the generation of morphometric maps for surface dynamics and basin analysis. TecDEM therefore allows the extraction of parameters such as isobase, incision, drainage density and surface roughness maps. We also provide tools for basin asymmetry and hypsometric analysis. These are efficient graphical user interfaces (GUIs) for mapping drainage deviation from basin mid-line and basin hypsometry. A morphotectonic interpretation of the Kaghan Valley (Northern Pakistan) is performed with TecDEM and the findings indicate a high correlation between surface dynamics and basin analysis parameters with neotectonic features in the study area.

  15. Variation of Radiation Belt Content Indices and total electron energy During Magnetic Storms Based On Van Allen Probe Observations

    Science.gov (United States)

    Xiong, Y.; Xie, L.; Chen, L.; Pu, Z.

    2017-12-01

    We investigate the variability of the RBC indices and total electron energy for varying energies within outer belt during 42 isolate magnetic storms based on the electron flux data from MagEIS and REPT onboard Van Allen Probe-A spacecraft. Van Allan Probes travel throughout the entire radiation belt twice during each orbit, providing an excellent opportunity to measure the electron's pitch angle distributions near the magnetic equatorial plane which is essential to calculate the RBC index accurately. Instead of assuming an isotropic electron pitch angle distribution which is widely used in previous studies, we develop a new and reliable technique to infer the equatorial pitch angle distributions based on the off-equator measurements. The statistic results show that the total electron energy in outer belt increase in 80% storms and has a positive correlation with median value of AE during recovery phase and minimum -Dst. The possibility of observing RBC depletion increase at high energies. The upper limit energy of RBC enhancement has a positive correlation with median value of AE and Vsw during recovery phase and a negative correlation with median value of Nsw during storm, which is consist of the balance of acceleration by chorus waves and loss by EMIC waves.

  16. Content validity and electronic PRO (ePRO) usability of the Lung Cancer Symptom Scale-Mesothelioma (LCSS-Meso) in mesothelioma patients.

    Science.gov (United States)

    Gelhorn, Heather L; Skalicky, Anne M; Balantac, Zaneta; Eremenco, Sonya; Cimms, Tricia; Halling, Katarina; Hollen, Patricia J; Gralla, Richard J; Mahoney, Martin C; Sexton, Chris

    2018-02-01

    Obtaining qualitative data directly from the patient perspective enhances the content validity of patient-reported outcome (PRO) instruments. The objective of this qualitative study was to evaluate the content validity of the Lung Cancer Symptom Scale for Mesothelioma (LCSS-Meso) and its usability on an electronic device. A cross-sectional methodological study, using a qualitative approach, was conducted among patients recruited from four clinical sites. The primary target population included patients with pleural mesothelioma; data were also collected from patients with peritoneal mesothelioma on an exploratory basis. Semi-structured interviews were conducted consisting of concept elicitation, cognitive interviewing, and evaluation of electronic patient-reported outcome (ePRO) usability. Participants (n = 21) were interviewed in person (n = 9) or by telephone (n = 12); 71% were male with a mean age of 69 years (SD = 14). The most common signs and symptoms experienced by participants with pleural mesothelioma (n = 18) were shortness of breath, fluid build-up, pain, fatigue, coughing, and appetite loss. The most commonly described symptoms for those with peritoneal mesothelioma (n = 4) were bloating, changes in appetite, fatigue, fluid build-up, shortness of breath, and pain. Participants with pleural mesothelioma commonly described symptoms assessed by the LCSS-Meso in language consistent with the questionnaire and a majority understood and easily completed each of the items. The ePRO version was easy to use, and there was no evidence that the electronic formatting changed the way participants responded to the questions. Results support the content validity of the LCSS-Meso and the usability of the electronic format for use in assessing symptoms among patients with pleural mesothelioma.

  17. Teacher education services based on the Semantic Web: the experience of the Share.tec project

    Directory of Open Access Journals (Sweden)

    Stefania Bocconi

    2012-08-01

    Full Text Available This work describes some of the web services that have been developed within the Share.TEC project to foster access, sharing and reuse of Teacher Education digital resources at European level. The Share.TEC platform features personalized functions to help users search for and select educational material via a broad repository of metadata records. These describe educational resources from various European countries and draw on an ontology that captures concepts pertaining to teacher education and maps them across a variety of cultural and linguistic contexts. The article also presents Share.TEC’s adaptivity mechanisms, in particular the recommending functionality. This provides extra search support that reduces the need to explicitly specify all the query parameters. Finally, the article reports on the project’s impact on the European Teacher Education sector, and on future development directions.

  18. Improving Science Teacher Preparation through the APS PhysTEC and NSF Noyce Programs

    Science.gov (United States)

    Williams, Tasha; Tyler, Micheal; van Duzor, Andrea; Sabella, Mel

    2013-03-01

    Central to the recruitment of students into science teaching at a school like CSU, is a focus on the professional nature of teaching. The purpose of this focus is twofold: it serves to change student perceptions about teaching and it prepares students to become teachers who value continued professional development and value the science education research literature. The Noyce and PhysTEC programs at CSU place the professional nature of teaching front and center by involving students in education research projects, paid internships, attendance at conferences, and participation in a new Teacher Immersion Institute and a Science Education Journal Reading Class. This poster will focus on specific components of our teacher preparation program that were developed through these two programs. In addition we will describe how these new components provide students with diverse experiences in the teaching of science to students in the urban school district. Supported by the NSF Noyce Program (0833251) and the APS PhysTEC Program.

  19. Effect of dose rate, temperature and impurity content on the radiation damage in the electron irradiated NaCl crystals

    NARCIS (Netherlands)

    Dubinko, V.I.; Turkin, A.A.; Vainshtein, D.I.; Hartog, H.W. den

    The dependencies of void formation and radiolytic sodium accumulation on the irradiation dose, dose rate, temperature and impurity content are analyzed within a framework of a theoretical model, which is based on a new mechanism of dislocation climb. The mechanism involves the production of V-F

  20. The effects of mass media on corruption in South Africa: A MTAR-TEC persepctive

    OpenAIRE

    Naomi Motlhasedi; Andrew Phiri

    2015-01-01

    This study becomes the first to examine cointegration and causal effects between mass media and corruption in South Africa for interpolated quarterly data of the corruption perception index and the world press freedom index conducted between the period of 2002 and 2014. The method of empirical investigation is the momentum threshold autoregressive (MTAR) model with a corresponding threshold error correction (TEC) component. Our empirical results reveal a negative long-run cointegration relati...

  1. [TEC promoter mediates P210(bcr/abl) gene expression in BaF3 cells].

    Science.gov (United States)

    Zhu, Yu-Feng; Wang, Yuan-Zhan; Meng, Fan-Yi

    2012-06-01

    P210(bcr/abl) transgene mouse is a good model to research the chronic myelogenous leukemia (CML), but the P210(bcr/abl) gene has a lethal effect on embryogenesis if driven by the constitutive promoter. So, the use of promoter which induces the special expression in hematopoietic tissue is the key to construct CML transgenic mice. This study was purposed to investigate the TEC promoter mediated P210(bcr/abl) gene expression in BaF3 cells. The CMVie promotes of IRES2-eGFP vector was replaced with the -364-+22 domain of TEC promoter cloned from mouse genome, and the P210(bcr/abl) gene was inserted into the EcoR I site of TEC-IRES2-eGFP vector. Then, the constructed vector was transfected into the BaF3 cells and 293 cells respectively. The expression levels of eGFP gene and P210(bcr/abl) gene in BaF3 and 293 cells were detected. The results showed that with fluorescent microscopy and flow cytometry, the eGFP gene was found to be expressed in the BaF3 cells, the expression rate was 7.10%, 23.35%, 64.61% at 6, 24, 72 h respectively after transfection, but the fluorescence was not seen in 293 cells. A 372 bp fragment of BCR/ABL mRNA was amplified by RT-PCR in BaF3 cells, but not in 293 cells. It is concluded that the -364-+22 domain of TEC promoter can mediate high-effective and specific expression of related genes in hematopoietic tissue, which can be used to construct P210(bcr/abl) transgene mice model.

  2. TID Parameters over the Antarctic Peninsula as Derived from TEC Measurements.

    Science.gov (United States)

    Paznukhov, V.; Galushko, V.; Groves, K. M.; Sopin, A.; Yampolski, Y.

    2014-12-01

    Results of TID analysis from multi-site TEC observations over the Antarctic Peninsula for the period from 2009 to 2012 are presented. Diurnal dependences of the occurrence frequency, and motion velocity and direction probability density distributions are determined for middle-scale traveling ionospheric disturbances (MSTIDs). TID parameters are calculated using dynamic approach to the problem of ionospheric disturbance diagnostics which has been extended to allow for an arbitrary waveform of TEC perturbations. We have also developed a dedicated algorithm to determine the presence of TID disturbances in the TEC records which is based on the correlation analysis. Statistical treatment of the obtained results shows that during daytime the TIDs propagate predominantly in the northern and northeastern directions. In the evening and nocturnal hours the northwestern direction is prevailing, with the characteristic TID velocities range from 10 to 250 m/s. The most probable TID velocities are tens of meters per second, while the mean values are equal to about 100 - 130 m/s. During the daytime the velocities of the ionospheric disturbances are even higher. The work also presents variations of the TID parameters with seasons and geomagnetic conditions and the role of the solar terminator as a possible source of the disturbances is discussed.

  3. Electronic states and band alignment in GalnNAs/GaAs quantum-well structures with low nitrogen content

    Science.gov (United States)

    Hetterich, M.; Dawson, M. D.; Egorov, A. Yu.; Bernklau, D.; Riechert, H.

    2000-02-01

    We investigate the electronic states in strained Ga0.62In0.38N0.015As0.985/GaAs multiple- quantum-well structures using photoluminescence and (polarized) photoluminescence excitation measurements at low temperature. From a theoretical fit to the experimental data, a type-I band alignment for the heavy holes with a strained conduction-band offset ratio of about 80% is obtained, while the light holes show an approximately flat band alignment. Additionally, our results suggest an increased effective electron mass in GaInNAs, possibly due to the interaction of the conduction band with nitrogen-related resonant states, an observation prospectively of benefit for GaInNAs-based diode lasers.

  4. New Content Addressable Memory (CAM) Technologies for Big Data and Intelligent Electronics Enabled by Magneto-Electric Ternary CAM

    Science.gov (United States)

    2017-12-11

    higher frequency than its intrinsic search delay. Furthermore, the MeTCAM incorporates the state-of-the art nonvolatile memory device, the voltage...faster speed compared to the software lookup. There are two types of CAM: binary CAM and ternary CAM (TCAM). Especially, TCAM has not only two binary...scalability. These characteristics allow MTJs interacting with the-state-of-the- art charge- based electronics on the same chip as a non-volatile

  5. SynTec Final Technical Report: Synthetic biology for Tailored Enzyme cocktails

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Janine [Novozymes, Inc., Davis, CA (United States); Teter, Sarah [Novozymes, Inc., Davis, CA (United States)

    2016-06-30

    Using a novel enzyme screening method inspired by synthetic biology, Novozymes developed new technology under SynTec which allows for more rapidly tailoring of enzyme cocktails. The methodology can be applied to specific feedstocks, and or coupled to address a specific hydrolytic conversion process context. Using combinatorial high throughput screening of libraries of enzyme domains, we can quickly assess which combination of catalytic modules delivers the best performance for a specific condition. To demonstrate the effectiveness of the screening process, we measured performance of the output catalytic cocktail compared to CTec3/HTec3. SynTec benchmark cocktail - blend of Cellic® CTec3 and HTec3. The test substrate was - ammonia fiber expansion pretreated corn stover (AFEX™ PCS).CTec3/HTec3 was assayed at the optimal pH and temperature, and also in the absence of any pH adjustment. The new enzyme cocktail discovered under SynTec was assayed in the absence of any pH adjustment and at the optimal temperature. Conversion is delivered by SynTec enzyme at significant dose reduction relative to CTec3/HTec3 at the controlled pH optimum, and without titrant required to maintain pH, which delivers additional cost savings relative to current state of the art process. In this 2.5 year $4M project, the team delivered an experimental cocktail that significantly outperformed CTec3/HTec3 for a specific substrate, and for specific hydrolysis conditions. As a means of comparing performance improvement delivered per research dollar spent, we note that SynTec delivered a similar performance improvement to the previous award, in a shorter time and with fewer resources than for the previously successful DOE project DECREASE, a 3.5 year, $25M project, though this project focused on a different substrate and used different hydrolysis conditions. The newly implemented technology for rapid sourcing of new cellulases and hemicellulases from nature is an example of Novozymes

  6. Comparison of double dose plateletpheresis on the Fenwal Amicus, Fresenius COM.TEC and Trima Accel cell separators.

    Science.gov (United States)

    Keklik, Muzaffer; Eser, Bulent; Kaynar, Leylagul; Solmaz, Musa; Ozturk, Ahmet; Yay, Mehmet; Birekul, Ayse; Oztekin, Mehmet; Sivgin, Serdar; Cetin, Mustafa; Unal, Ali

    2014-10-01

    A variety of apheresis instruments are now available on the market for double dose plateletpheresis. We compared three apheresis devices (Fenwal Amicus, Fresenius COM.TEC and Trima Accel) with regard to processing time, platelet (PLT) yield, collection efficiency (CE) and collection rate (CR). The single-needle or double-needle double plateletpheresis procedures of the three instruments were compared in a retrospective, randomized study in 135 donors. In the pre-apheresis setting, 45 double plateletpheresis procedures performed with each instrument revealed no significant differences in donor's age, sex, weight, hemoglobin, white blood cell and PLT count between three groups. The blood volume processed to reach a target PLT yield of ≥ 6 × 10(11) was higher in the COM.TEC compared with the Amicus and Trima (4394 vs. 3780 and 3340 ml, respectively; p TEC compared with the Amicus and Trima (426 vs. 387 and 329 ml, respectively; p TEC compared with the Amicus and Trima (66 vs. 62 and 63 min, respectively; p = 0.024). The CE was significantly higher with the Trima compared with the Amicus and COM.TEC (83.57 ± 17.19 vs. 66.71 ± 3.47 and 58.79 ± 5.14%, respectively; p TEC (395.56 vs. 363.11 and 386.4 ml, respectively; p = 0.008). Additionally, the CR was significantly lower with the COM.TEC compared with the Amicus and Trima (0.092 ± 0.011 vs. 0.099 ± 0.013 and 0.097 ± 0.013 plt × 10(11)/min, respectively; p = 0.039). There was no significant differences in PLT yield between the three groups (p = 0.636). Trima single-needle device collected double dose platelets more efficiently than Amicus and COM.TEC double-needle devices. Blood volume processed, ACD-A volume, and median separation time was significantly higher with the COM.TEC. Also, the CR was significantly lower with the COM.TEC. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Analysis on optimal heat exchanger size of thermoelectric cooler for electronic cooling applications

    International Nuclear Information System (INIS)

    Zhu, Lin; Tan, Hongbo; Yu, Jianlin

    2013-01-01

    Highlights: • Optimization of a thermoelectric cooler system is presented. • The total heat transfer area of heat exchangers is considered as a constraint. • The best performances are characterized by different optimal area allocation ratios. • Optimal area allocation ratios are mainly affected by hot side thermal conductance. - Abstract: In this paper, the theoretical analyses are conducted to explore the optimization problems of thermoelectric cooler (TEC) systems applied in electronic cooling. The study mainly focuses on the optimal heat exchanger configuration of a TEC system. The effects of total heat transfer area allocation ratio, thermal conductance of the TEC hot and cold side and TEM element material properties on the cooling performance of the TEC are investigated in detailed based on the developed mathematical model. The analysis results indicate that the highest coefficient of performance (COP), highest heat flux pumping capability of the TEC and lowest cold side temperature can be achieved by selecting an optimal heat transfer area allocation ratio. The optimal heat transfer area allocation ratio mainly depends on the relevant objective functions, the hot and cold side thermal conductance, total heat exchanger size and the TEM element material properties. These results reveal that the heat transfer area allocation ratio is an applicable characteristic of optimum design for TEC systems. It is hoped that the considerations and analysis results may provide guides for the design and application of practical thermoelectric cooler system in electronic cooling

  8. Practical guide to content delivery networks

    CERN Document Server

    Held, Gilbert

    2005-01-01

    With a practical and organized approach to learning and implementation, A Practical Guide to Content Delivery Networks presents a step-by-step process for building a highly available and highly scalable content delivery network (CDN). CDN refers to the infrastructure behind any service that provides utility or access to data to an end user. This book offers terminology, tactics, potential problems to avoid, and individual layers of design, providing clear understanding of the framework for CDNs using a structural and visual approach. The text emphasizes a best-of-breed strategy, allowing a tec

  9. Human health and ecological toxicity potentials due to heavy metal content in waste electronic devices with flat panel displays

    International Nuclear Information System (INIS)

    Lim, Seong-Rin; Schoenung, Julie M.

    2010-01-01

    Display devices such as cathode-ray tube (CRT) televisions and computer monitors are known to contain toxic substances and have consequently been banned from disposal in landfills in the State of California and elsewhere. New types of flat panel display (FPD) devices, millions of which are now purchased each year, also contain toxic substances, but have not previously been systematically studied and compared to assess the potential impact that could result from their ultimate disposal. In the current work, the focus is on the evaluation of end-of-life toxicity potential from the heavy metal content in select FPD devices with the intent to inform material selection and design-for-environment (DfE) decisions. Specifically, the metals antimony, arsenic, barium, beryllium, cadmium, chromium, cobalt, copper, lead, mercury, molybdenum, nickel, selenium, silver, vanadium, and zinc in plasma TVs, LCD (liquid crystal display) TVs, LCD computer monitors and laptop computers are considered. The human health and ecotoxicity potentials are evaluated through a life cycle assessment perspective by combining data on the respective heavy metal contents, the characterization factors in the U.S. EPA Tool for the Reduction and Assessment of Chemical and other environmental Impacts (TRACI), and a pathway and impact model. Principal contributors to the toxicity potentials are lead, arsenic, copper, and mercury. Although the heavy metal content in newer flat panel display devices creates less human health toxicity potential than that in CRTs, for ecological toxicity, the new devices are worse, especially because of the mercury in LCD TVs and the copper in plasma TVs.

  10. Human health and ecological toxicity potentials due to heavy metal content in waste electronic devices with flat panel displays.

    Science.gov (United States)

    Lim, Seong-Rin; Schoenung, Julie M

    2010-05-15

    Display devices such as cathode-ray tube (CRT) televisions and computer monitors are known to contain toxic substances and have consequently been banned from disposal in landfills in the State of California and elsewhere. New types of flat panel display (FPD) devices, millions of which are now purchased each year, also contain toxic substances, but have not previously been systematically studied and compared to assess the potential impact that could result from their ultimate disposal. In the current work, the focus is on the evaluation of end-of-life toxicity potential from the heavy metal content in select FPD devices with the intent to inform material selection and design-for-environment (DfE) decisions. Specifically, the metals antimony, arsenic, barium, beryllium, cadmium, chromium, cobalt, copper, lead, mercury, molybdenum, nickel, selenium, silver, vanadium, and zinc in plasma TVs, LCD (liquid crystal display) TVs, LCD computer monitors and laptop computers are considered. The human health and ecotoxicity potentials are evaluated through a life cycle assessment perspective by combining data on the respective heavy metal contents, the characterization factors in the U.S. EPA Tool for the Reduction and Assessment of Chemical and other environmental Impacts (TRACI), and a pathway and impact model. Principal contributors to the toxicity potentials are lead, arsenic, copper, and mercury. Although the heavy metal content in newer flat panel display devices creates less human health toxicity potential than that in CRTs, for ecological toxicity, the new devices are worse, especially because of the mercury in LCD TVs and the copper in plasma TVs. Copyright (c) 2009 Elsevier B.V. All rights reserved.

  11. Olive Oil Total Phenolic Contents and Sensory Sensations Trends during Oven and Microwave Heating Processes and Their Discrimination Using an Electronic Tongue

    Directory of Open Access Journals (Sweden)

    Rafaela Prata

    2018-01-01

    Full Text Available Olive oil has unique organoleptic attributes and its consumption is associated with nutritional and health benefits, which are mainly related to its rich composition in phenolic and volatile compounds. The use of olive oil in heat-induced cooking leads to deep reduction of phenolic and volatile concentrations and to changes of the sensory profiles. This work confirmed that oven and microwave heating significantly reduced total phenolic contents (P value < 0.0001, one-way ANOVA, more pronounced in the latter, together with a significant reduction of the intensity of fruity, sweet, bitter, pungent, and green attributes (P value < 0.0001, Kruskal-Wallis test, particularly for fruity and green sensations. Besides, bitter, fruity, green, and pungent intensities showed a linear dependency with the total phenolic contents (0.8075≤R-Pearson ≤ 0.9694. Finally, the potentiometric electronic tongue together with linear discriminant analysis-simulated annealing algorithm allowed satisfactory discrimination (sensitivities of 94±4%, for repeated K-fold cross-validation of olive oils subjected to intense microwave heating (5–10 min, 160–205°C from those processed under usual cooking conditions (oven heating during 15–60 min or microwave heating during 1.5–3 min, 72–165°C. This could be due to the different responses of the electronic tongue towards olive oils with diverse phenolic and sensory profiles.

  12. Trapped electron spectra in hydrates of sodium, potassium and tetraalkylammonium hydroxides of varying H2O content

    International Nuclear Information System (INIS)

    Zagorski, Z.P.; Grodkowski, J.; Bobrowski, K.

    1980-01-01

    Transient spectra of e - sub(t) in hydrates at room temperature obtained by pulse radiolysis with Cerenkov L.S.M. are presented. The decrease in number of H 2 O molecules n, in KOH.nH 2 O and NaOH.nH 2 O is accompanied by a blue shift of the absorption maximum. The same tendency is observed in concentrated solutions. The shifts in tetraalkylammonium hydroxides are not as extended as in KOH and NaOH systems, because TAAH's coordinate more H 2 O molecules and the preparation of solution of higher concentration is not possible. Freezing of hydrates does not change the e - sub(t) spectrum considerably. The concept of the trap containing one molecule of water and one electron is discussed in the general context of the phenomena. (author)

  13. Medium Calcium Concentration Determines Keratin Intermediate Filament Density and Distribution in Immortalized Cultured Thymic Epithelial Cells (TECs)

    Science.gov (United States)

    Sands, Sandra S.; Meek, William D.; Hayashi, Jun; Ketchum, Robert J.

    2005-08-01

    Isolation and culture of thymic epithelial cells (TECs) using conventional primary tissue culture techniques under conditions employing supplemented low calcium medium yielded an immortalized cell line derived from the LDA rat (Lewis [Rt1l] cross DA [Rt1a]) that could be manipulated in vitro. Thymi were harvested from 4 5-day-old neonates, enzymically digested using collagenase (1 mg/ml, 37°C, 1 h) and cultured in low calcium WAJC404A medium containing cholera toxin (20 ng/ml), dexamethasone (10 nM), epidermal growth factor (10 ng/ml), insulin (10 [mu]g/ml), transferrin (10 [mu]g/ml), 2% calf serum, 2.5% Dulbecco's Modified Eagle's Medium (DMEM), and 1% antibiotic/antimycotic. TECs cultured in low calcium displayed round to spindle-shaped morphology, distinct intercellular spaces (even at confluence), and dense reticular-like keratin patterns. In high calcium (0.188 mM), TECs formed cobblestone-like confluent monolayers that were resistant to trypsinization (0.05%) and displayed keratin intermediate filaments concentrated at desmosomal junctions between contiguous cells. Changes in cultured TEC morphology were quantified by an analysis of desmosome/membrane relationships in high and low calcium media. Desmosomes were significantly increased in the high calcium medium. These studies may have value when considering the growth conditions of cultured primary cell lines like TECs.

  14. Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk.

    Science.gov (United States)

    Readinger, Julie A; Mueller, Kristen L; Venegas, Ana M; Horai, Reiko; Schwartzberg, Pamela L

    2009-03-01

    The Tec (tyrosine kinase expressed in hepatocellular carcinoma) family of non-receptor tyrosine kinases consists of five members: Tec, Bruton's tyrosine kinase (Btk), inducible T-cell kinase (Itk), resting lymphocyte kinase (Rlk/Txk), and bone marrow-expressed kinase (Bmx/Etk). Although their functions are probably best understood in antigen receptor signaling, where they participate in the phosphorylation and regulation of phospholipase C-gamma (PLC-gamma), it is now appreciated that these kinases contribute to signaling from many receptors and that they participate in multiple downstream pathways, including regulation of the actin cytoskeleton. In T cells, three Tec kinases are expressed, Itk, Rlk/Txk, and Tec. Itk is expressed at highest amounts and plays the major role in regulating signaling from the T-cell receptor. Recent studies provide evidence that these kinases contribute to multiple aspects of T-cell biology and have unique roles in T-cell development that have revealed new insight into the regulation of conventional and innate T-cell development. We review new findings on the Tec kinases with a focus on their roles in T-cell development and mature T-cell differentiation.

  15. Tec kinases regulate actin assembly and cytokine expression in LPS-stimulated human neutrophils via JNK activation.

    Science.gov (United States)

    Zemans, Rachel L; Arndt, Patrick G

    2009-01-01

    The acute inflammatory response involves neutrophils wherein recognition of bacterial products, such as lipopolysaccharide (LPS), activates intracellular signaling pathways. We have shown that the mitogen-activated protein kinase (MAPK) c-Jun NH(2) terminal kinase (JNK) is activated by LPS in neutrophils and plays a critical role in monocyte chemoattractant protein (MCP)-1 expression and actin assembly. As the Tec family kinases are expressed in neutrophils and regulate activation of the MAPKs in other cell systems, we hypothesized that the Tec kinases are an upstream component of the signaling pathway leading to LPS-induced MAPKs activation in neutrophils. Herein, we show that the Tec kinases are activated in LPS-stimulated human neutrophils and that inhibition of the Tec kinases, with leflunomide metabolite analog (LFM-A13), decreased LPS-induced JNK, but not p38, activity. Furthermore, LPS-induced actin polymerization as well as MCP-1, tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta expression are dependent on Tec kinase activity.

  16. Manipulating the Energetics and Rates of Electron Transfer in Rhodobacter capsulatus Reaction Centers with Asymmetric Pigment Content.

    Science.gov (United States)

    Faries, Kaitlyn M; Dylla, Nicholas P; Hanson, Deborah K; Holten, Dewey; Laible, Philip D; Kirmaier, Christine

    2017-07-27

    Seemingly redundant parallel pathways for electron transfer (ET), composed of identical sets of cofactors, are a cornerstone feature of photosynthetic reaction centers (RCs) involved in light-energy conversion. In native bacterial RCs, both A and B branches house one bacteriochlorophyll (BChl) and one bacteriopheophytin (BPh), but the A branch is used exclusively. Described herein are the results obtained for two Rhodobacter capsulatus RCs with an unnaturally high degree of cofactor asymmetry, two BPh on the RC's B side and two BChl on the A side. These pigment changes derive, respectively, from the His(M180)Leu mutation [a BPh (Φ B ) replaces the B-side BChl (B B )], and the Leu(M212)His mutation [a BChl (β A ) replaces the A-side BPh (H A )]. Additionally, Tyr(M208)Phe was employed to disfavor ET to the A branch; in one mutant, Val(M131)Glu creates a hydrogen bond to H B to enhance ET to H B . In both Φ B mutants, the decay kinetics of the excited primary ET donor (P*) resolve three populations with lifetimes of ∼9 ps (50-60%), ∼40 ps (10-20%), and ∼200 ps (20-30%), with P + Φ B - formed predominantly from the 9 ps fraction. The 50-60% yield of P + Φ B - is the highest yet observed for a Φ B -containing RC. The results provide insight into factors needed for efficient multistep ET.

  17. Evaluation of Hi-Tec Implant Restoration in Mandibular First Molar Region- A Prospective Clinical Study.

    Science.gov (United States)

    Sreeram, Roopa Rani S; Prasad, L Krishna; Chakravarthi, P Srinivas; Devi, Naga Neelima; Kattimani, Vivekanand S; Sreeram, Sanjay Krishna

    2015-08-01

    Missing teeth lead to loss of structural balance, inefficient function, poor aesthetics and psychological effects on human beings, which needs restoration for normal contour, function and aesthetics. Several natural or synthetic substitutes are being used for replacement of missing tooth since centuries. Implants are the latest modality of replacement. So, the study was aimed to assess clinical success rate of Hi-Tec implant; which is economical and new in market. Results of the study will help clinician for appropriate implant selection. The study included 10 patients from 19 to 31 years and needed restoration of missing mandibular first molar. Restoration had done using Hi Tec Single-tooth implants with metal-ceramic single crown prosthesis after three months of osseointegration. The implants were evaluated clinically (bleeding on probing, probing depth, implant mobility- periotest) and radiographically (marginal bone loss and peri-implant radiolucency) for six years. The observers were blinded for the duration of the study to prevent bias. All the patients had uneventful post-surgical healing. No bleeding on probing, Implant mobility, peri-implant radiolucency with minimal marginal bone loss and constant probing depths were observed well within the normal range during follow-up periods. Two stage single-tooth Hi Tec implant restoration can be used as a successful treatment modality for replacing mandibular first molar in an economic way. However, these results were obtained after 6 years of follow up with a smaller sample size, so long term multi center studies with a larger sample size is recommended for the predictability of success rate conclusively.

  18. [Role of non-receptor tyrosine kinase Tec in the production of pro-inflammatory cytokines from macrophages induced by endotoxin/lipopolysaccharide].

    Science.gov (United States)

    Wang, Chao; Wang, Fei; Zhou, Bo; Qiu, Le; Wang, Jian; Liu, Sheng; Chen, Xulin

    2015-02-01

    To investigate the role of non-receptor tyrosine kinase Tec in the production of TNF-α and IL-1β from macrophages induced by LPS and its related mechanism. RAW264.7 mononuclear-macrophages cultured in 6-well plates were divided into 4 groups according to the random number table, with 24 wells in each group. Cells in blank group were routinely cultured (cultured with DMEM medium containing 10% FBS) for 2 hours. Cells in LFM-A13 group were pretreated with 75 µmol/L Tec specific inhibitor LFM-A13 for 1 hour and then routinely cultured for 1 hour. Cells in LPS group were routinely cultured for 1 hour and then treated with 0.1 µg/mL LPS for 1 hour. Cells in LPS+LFM-A13 group were pretreated with 75 µmol/L LFM-A13 for 1 hour and then treated with 0.1 µg/mL LPS for 1 hour. The content of TNF-α and IL-1β in culture supernatant of cells was determined with ELISA. The mRNA expressions of TNF-α and IL-1β in cells were assayed with real-time fluorescent quantitative RT-PCR. The activity of intracellular Tec, p38 MAPK, and transforming growth factor activated kinase 1 (TAK1) was determined with Western blotting. Data were processed with one-way analysis of variance and LSD test. The content of TNF-α and IL-1β in culture supernatant of cells in LFM-A13 group was close to that in blank group (with P values above 0.05). The mRNA expressions of TNF-α and IL-1β in the cells of LFM-A13 group were close to those of blank group (with P values above 0.05). The content of TNF-α and IL-1β in culture supernatant of cells in LPS group was respectively (1 213 ± 154) and (636 ± 90) pg/mL, which was higher than that in blank group [(330 ± 44) and (211 ± 31) pg/mL, with P values below 0.01]. The mRNA expressions of TNF-α and IL-1β in the cells of LPS group were respectively 1.57 ± 0.22 and 1.44 ± 0.24, which were significantly higher than those of blank group (1.00 ± 0.18 and 1.00 ± 0.19, with P values below 0.01). The content of TNF-α and IL-1β in culture

  19. Combined TOPEX/Poseidon TEC and ionosonde observations of negative low-latitude ionospheric storms

    Directory of Open Access Journals (Sweden)

    K. J. W. Lynn

    2004-09-01

    Full Text Available Ionospheric storms showing a strong depression in daytime foF2 values were sought which penetrated to low-latitudes, as identified by vertical ionosondes operating at Darwin and Townsville over the period 1992-1998. The 32 storms thus identified showed a seasonal occurrence peaking near the equinoxes with a bias to the summer side. Of these storms, three (27 March 1995, 25 October 1997, 8 November 1997 combined Australian and South East Asian ionosonde observations with local afternoon TOPEX/Poseidon measurements of TEC. The equatorial anomaly is usually well developed at this time of day and consequently these storms were chosen for detailed study. The TOPEX/Poseidon satellite provided vertical profiles of the ionosphere across both hemispheres, thus allowing the totality of storm behaviour to be observed for the first time at low-latitudes and related directly to the ionosonde observations. The three storms were remarkably consistent in their behaviour, the negative ionospheric storm day followed some 24-36h after the beginning of a magnetic storm and the development of the equatorial anomaly was suppressed. However, the suppression of the equatorial anomaly was not the main cause of the strong depression in foF2 observed by the Southern Hemisphere ionosondes. The latter was associated with an additional bite-out in both TEC and foF2 that occurred on the southern side of the magnetic equator. None of the three storms produced any major negative disturbance outside the range of normal variability of TEC and foF2 at the northern latitude sites for which data was available, despite the absence of the anomaly. The satellite measurements show the strength of the anomaly to be highly variable from day-to-day and anomaly peaks are frequently not present even on magnetically quiet days. Thus, an absence of anomaly peaks is contained within the normal variability of non-storm days. The north-south asymmetry and seasonal occurrence are consistent with

  20. Agonistic anti-CD40 promotes early development and increases the incidence of severe thyroid epithelial cell hyperplasia (TEC H/P) in CD4-/- mice.

    Science.gov (United States)

    Yu, Shiguang; Downey, Edward F; Braley-Mullen, Helen

    2013-10-01

    IFN-γ-/-NOD.H-2h4 mice develop thyroid epithelial cell hyperplasia (TEC H/P) characterised by abnormal proliferation of thyrocytes and infiltration of thyroids by CD4+ and CD8+ T cells, macrophages and dendritic cells. CD8+ T cells from mice with severe TEC H/P transfer similar lesions to SCID recipients, whereas CD4+ T cells transfer mild TEC H/P. CD4- and CD8- deficient IFN-γ-/-NOD.H-2h4 mice were generated to determine if CD4+ T cells were required for initial activation of the CD8+ T cells that transfer TEC H/P. After 6-8 months on NaI water, only 2 of 60 CD8-/- mice developed severe TEC H/P, whereas 31 of 101 CD4-/- mice developed severe TEC H/P and fibrosis comparable in severity to that of IFN-γ-/- mice. However, splenocytes from CD4-/- mice with severe TEC H/P did not effectively transfer severe TEC H/P to SCID recipients. When CD4-/- donors were given agonistic anti-CD40 mAb, most developed severe TEC H/P and their cells transferred severe TEC H/P to SCID recipients. These results indicate that agonistic anti-CD40 can provide an important signal for activation of autoreactive CD8+ T cells that transfer severe TEC H/P. Therefore, targeting or blocking CD40 could provide effective therapy for diseases involving hyperplasia and fibrosis mediated by CD8+ T cells.

  1. Bad news about an old poison. A case of nicotine poisoning due to both ingestion and injection of the content of an electronic cigarette refill

    Directory of Open Access Journals (Sweden)

    Gianfranco Cervellin

    2013-10-01

    Full Text Available There are increasing concerns about the escalating use of electronic cigarettes (e-cigarettes. In particular, smokers have been advised by important agencies such as the US Food and Drug Administration about the potential harm to the health of these products, being now considered as drug delivery devices. The leading issues supporting this statement include the repeated inhalation of propylene glycol that is used as a diluent in refills, accidental poisoning, as well as evidence that ecigarettes may promote continued smoking since their use may compromise quitting motivations. Some authors have minimized these risks, considering the potential advantages of these devices for public health. Here we describe the first case of nicotine poisoning due to both ingestion and intravenous injection of the content of an e-cigarette refill, incorrectly mixed with methadone, bottled in a generic vial.

  2. Overview of the Performance of the Compact Total Electron Content Sensor (CTECS) on the Space Environmental NanoSatellite Experiment (SENSE)

    Science.gov (United States)

    Bishop, R. L.; Hansel, S.; Stoffel, D.; Ping, D.; Bardeen, J.; Chin, A.; Bielat, S.; Mulligan, T. L.

    2014-12-01

    The Air Force's Space & Missile Systems Center (SMC) SENSE mission consists of two identical cubesat buses with space weather payloads. One of the goals of the SENSE mission is to demonstrate the operational potential and usefulness of space weather measurements from a cubesat platform. The payloads on the two cubesats include the Cubesat Tiny Ionospheric Photometer (SRI), Wind Ion Neutral Composite Suite (NRL), and Compact Total Electron Content GPS radio occultation sensor (CTECS). After initial contact with both space vehicles (SV), we were able to confirm successful operation of both CTECS. Because of power issues on SV2, only SV1 has provided consistent data. In this presentation, we present an overview of the CTECS sensor. Then we present initial CTECS data, discuss the data quality, and lessons learned.

  3. Factors Influencing the Effective Use of Technology for Teaching and Learning: Lessons Learned from the SEIR-TEC Intensive Site Schools. 2nd Edition.

    Science.gov (United States)

    Byrom, Elizabeth; Bingham, Margaret

    From 1995 to 2000, the SouthEast Initiatives Regional Technology in Education Consortium (SEIR-TEC) provided technical assistance and professional development to 12 schools, referred to as intensive sites. Typically, this effort entailed a member of the SEIR-TEC staff spending three or four days per month working with teachers and administrators…

  4. THERMOELECTRIC DEVICES TO PROVIDE THERMAL BLOCK MODE ELECTRONIC SYSTEMS

    Directory of Open Access Journals (Sweden)

    T. A. Ismailov

    2015-01-01

    Full Text Available The article deals with thermoelectric cooling (TEC device to provide thermal mode power electronics systems cluster design, are areas of constructive solutions use the feasibility study of the device, a description of the experimental facility and methodology of the experiment, the dependences of temperature on the simulator of the electronic board from the exhaust of the feasibility study power, temperatures of hot and cold junctions, the speed of the air flow and the distance between the electronic boards. 

  5. Anti-IL-2 receptor antibody decreases cytokine-induced apoptosis of human renal tubular epithelial cells (TEC).

    Science.gov (United States)

    Wang, Shuang; Zhang, Zhu-Xu; Yin, Ziqin; Liu, Weihua; Garcia, Bertha; Huang, Xuyan; Acott, Philip; Jevnikar, Anthony M

    2011-07-01

    Transplant rejection is mediated by T-cell activation which is modulated by interleukin-2 (IL-2) binding to IL-2R (CD25). Monoclonal anti-IL-2 receptor antibody is used in renal transplantation to reduce rejection. Interestingly, proximal tubular epithelial cells (TEC) express CD25, similar to T cells. We have demonstrated that IL-2 induces murine TEC apoptosis through down-regulation of the caspase-8 inhibitor protein c-FLIP. Anti-CD25 antibody may be useful clinically to limit renal injury, but this has not been tested in human TEC. Human PT-2 TEC were isolated and cloned from the urine of transplant patients. Apoptosis was determined by FACS with Annexin-V FITC. Protein expression was studied using western blot, and mRNA levels by quantitative real-time (PR-PCR). We demonstrated that the morphology of a human kidney cell line (PT-2) cloned from urine was consistent with proximal TEC and expresses alkaline phosphatase, cytokeratin, vimentin, CD13, CD26, and low levels of E-cadherin. Basal IL-2 receptor (CD25) was up-regulated by IL-2/IFN-γ stimulation, and cytokine exposure induced apoptosis in a dose-dependent manner. Apoptosis with IL-2/IFN-γ was associated with increased caspase-8 activity and decreased endogenous caspase-8 inhibitor c-FLIP mRNA and protein expression. IL-2/IFN-γ-induced apoptosis could be blocked by pre-treatment of PT-2 with anti IL-2R antibody (basiliximab) but not control IgG antibody. These data demonstrate for the first time in human TEC that IL-2 and IFN-γ can induce TEC apoptosis which can be blocked by CD25 blockade antibody. These data suggest that anti-CD25 mAb might similarly attenuate inflammation-induced TEC injury in vivo. Kidney-expressed CD25 may represent a clinically important new target for attenuating early inflammatory injury in donor kidneys and preserving renal function during anti-rejection therapy.

  6. Aspectos Fundamentales en la rehabilitación post tec en el paciente adulto y pediátrico

    OpenAIRE

    Dr. A. Claudio Soto; Dr. T. Pablo Salinas; G. Gabriela Hidalgo, Dra.

    2014-01-01

    El traumatismo encéfalo craneano (TEC) es una entidad compleja y heterogénea, que compromete principalmente a adultos jóvenes en etapas productivas de la vida, transformándose en un problema crítico de salud pública y socio-económico en todo el mundo. Los pacientes que sobreviven a un TEC como consecuencia presentan alteraciones funcionales secundarias a un trastorno cognitivo, motor y conductual, que generan una restricción a la participación en las actividades de la vida diaria y en su rein...

  7. Effect of Thermoelectric Cooling (TEC module and the water flow heatsink on Photovoltaic (PV panel performance

    Directory of Open Access Journals (Sweden)

    Amelia A.R.

    2017-01-01

    Full Text Available Photovoltaic (PV panel suffers in low conversion efficiency of the output performance affected by the elevated operating temperature of the PV panel. It is important to keep the PV panel to operate at low temperature. To address this issue, this paper proposes the cooling system using thermoelectric cooling (TEC and water block heatsink for enhancing the PV panel output performance. These both types cooling system were designed located on the back side of the PV panel to cool down the operating temperature of the PV panel. To evaluate the function for the existing cooling systems, the experiment was subsequently performed for PV panel without and with different design of the cooling system in outdoor weather conditions. By comparing the experimental results, it is concluded that by the hybrid cooling system which combining TEC module and the water block heatsink could improve the output performance of the PV panel. By the reduction temperature of the PV panel by 16.04 %, the average output power of the PV panel has been boosted up from 8.59 W to 9.03 W. In short, the output power of the PV panel was enhanced by the reduction of the operating temperature of the PV panel.

  8. Effect of Thermoelectric Cooling (TEC) module and the water flow heatsink on Photovoltaic (PV) panel performance

    Science.gov (United States)

    Amelia, A. R.; Jusoh, MA; Shamira Idris, Ida

    2017-11-01

    Photovoltaic (PV) panel suffers in low conversion efficiency of the output performance affected by the elevated operating temperature of the PV panel. It is important to keep the PV panel to operate at low temperature. To address this issue, this paper proposes the cooling system using thermoelectric cooling (TEC) and water block heatsink for enhancing the PV panel output performance. These both types cooling system were designed located on the back side of the PV panel to cool down the operating temperature of the PV panel. To evaluate the function for the existing cooling systems, the experiment was subsequently performed for PV panel without and with different design of the cooling system in outdoor weather conditions. By comparing the experimental results, it is concluded that by the hybrid cooling system which combining TEC module and the water block heatsink could improve the output performance of the PV panel. By the reduction temperature of the PV panel by 16.04 %, the average output power of the PV panel has been boosted up from 8.59 W to 9.03 W. In short, the output power of the PV panel was enhanced by the reduction of the operating temperature of the PV panel.

  9. Education and training for nuclear scientists and engineers at NuTEC/JAEA

    International Nuclear Information System (INIS)

    Kushita, Kouhei; Sugimoto, Jun; Sakamoto, Ryuichi; Arai, Nobuyoshi; Hattori, Takamitsu; Matsuda, Kenji; Ikuta, Yuko; Sato, K.

    2009-01-01

    Because of the increasing demand of nuclear engineers in recent years, which is sometimes called as the age of nuclear Renaissance, while nuclear engineers have been decreasing and technical knowledge and expertise have not necessarily been transferred to the younger generations, human resources development (HRD) has been regarded as one of the most important issues in the nuclear field in Japan as well as in the world. Nuclear Technology and Education Center (NuTEC) at Japan Atomic Energy Agency (JAEA) have conducted comprehensive nuclear education and training activities in the past half century, which cover; 1) education and training for domestic nuclear engineers, 2) cooperation with universities, and 3) international cooperation. The main feature of NuTEC's training programs is that emphasis is placed on the laboratory exercise with well-equipped training facilities and expertise of lecturers mostly from JAEA. The wide spectrum of cooperative activities have been pursued with universities, which includes newly developed remote-education system, and also with international organizations, such as with FNCA countries and IAEA. For the nuclear education and trainings, utilization of nuclear reactors is of special importance. Examples of training programs using nuclear reactors are reported. Future plan to use nuclear reactors such as JMTR for the nuclear educations is also introduced. (author)

  10. NuTEC annual report. April 1, 1996 - March 31, 1997

    International Nuclear Information System (INIS)

    1998-02-01

    This report summarizes the educational works carried out at the NuTEC (Nuclear Technology and Education Center) of Japan Atomic Energy Research Institute during the 1996 fiscal year. It covers the educational courses provided at Tokyo and Tokai Education Centers and the activities of the International Technology Transfer Division, together with the R and D works for improving the educational programs, and related management works. Today Japan has a mature nuclear industry and Japanese nuclear engineers have highly specialized knowledges. On the other hand, they are losing wide perspective over the whole spectrum of nuclear technology. In addition, a considerable gap exists between the specialists and the public in knowledge and interpretation or acceptance of nuclear power. This gap may enlarge the public concern of specific problems caused by small accidents into a mistrust of entire nuclear power industry. The work of NuTEC is aimed at improving these problems in both specialist and the public sides. During the 1996 fiscal year, Tokyo and Tokai Education Centers accomplished all the planned courses, both domestic and international: total number of the trainees during the year reached 1868. The newly established International Technology Transfer Division proceeded the preparation works of the international training courses, particularly the Asia-Pacific Nuclear Cooperation Program. In addition, various research and development efforts were made to establish new items in educational programs. (author)

  11. Investigation of the effects of aluminum stress on some macro and micro-nutrient contents of the seedlings of lycopersicon esculentum mill. by using scanning electron microscope

    International Nuclear Information System (INIS)

    Colak, G.; Catak, E.; Baykul, M.C.

    2014-01-01

    This study was planned to see the affect of aluminum stress on plant nutrition and metabolism. The effects of aluminum stress on uptake level of some macro- and micro-nutrients from the nutrition solution into the seedlings of Lycopersicon esculentum Mill. and on mobilization of some nutrient elements in the seedlings were examined at the level of epidermal cells. The elemental structure of root, hypocotyl and cotyledon epidermal cells were determined by Energy Dispersive Xray Microanalysis (EDX) performed in a local area 50 nm in diameter at the level of a single epidermal cell cytoplasm by using low vacuum (24 pascal ) Scanning Electron Microscope. EDX analysis revealed that aluminum content of the cells was increasing with the increased concentrations of aluminum in the nutrient solution and that aluminum largelyaccumulated in the roots. Aluminum concentration was much higher in the root epidermal cells of the seedlings incubated in aluminum containing media for 17 days without adding any nutrient solution; it was also true for the local EDX analysis of radicle epidermal cells from the same series. Aluminum stress was found to tend to modify the plant nutritional element content of the cells and this was particularly of critical importance in terms of some macro- and micro-nutrients. The assessments performed at the level of epidermal cells of young seedlings of Lycopersicon esculentum suggest that aluminum stress leads to an absolute change in the plant nutritional element composition of the cells and in the mobilization of some nutritional elements in the seedlings. (author)

  12. Microstructure evaluation of dermally applicable liquid crystals as a function of water content and temperature: Can electron paramagnetic resonance provide complementary data?

    Science.gov (United States)

    Matjaž, Mirjam Gosenca; Mravljak, Janez; Rogač, Marija Bešter; Šentjurc, Marjeta; Gašperlin, Mirjana; Pobirk, Alenka Zvonar

    2017-11-30

    Insight into the microstructure of lyotropic liquid crystals (LCs) is of crucial importance for development of novel dermal delivery systems. Our aim was to evaluate the phase behaviour of dermally applicable LCs composed of isopropyl myristate/Tween 80/lecithin/water, along the dilution line, where phase transitions are predominantly driven by increased water content. Additionally, identification of LC temperature dependence is of great importance for skin application. Selected LCs were evaluated using electron paramagnetic resonance (EPR) plus conventionally used methods of polarization microscopy, small-angle X-ray scattering, differential scanning calorimetry, and rheological measurements. Depending on water content, LCs formed diverse microstructures, from (pseudo)hexagonal (LC1) and lamellar (LC2-LC7) liquid crystalline phases that possibly co-exist with rod-like micelles (LC4-LC7), to a transitional micellar phase (LC8). Furthermore, the LCs microstructure remained unaltered within the tested temperature range. EPR was shown to detect microstructural transitions of LCs and to provide complementary data to other techniques. These data thus confirm the applicability of EPR as a complementary technique for better understanding of LC microstructural transitions that are expected to contribute greatly to studies oriented towards the drug release characteristics from such systems. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Investigation of trap states in high Al content AlGaN/GaN high electron mobility transistors by frequency dependent capacitance and conductance analysis

    Directory of Open Access Journals (Sweden)

    Jie-Jie Zhu

    2014-03-01

    Full Text Available Trap states in Al0.55Ga0.45N/GaN Schottky-gate high-electron-mobility transistors (S-HEMTs and Al2O3/Al0.55Ga0.45N/GaN metal-oxide-semiconductor HEMTs (MOS-HEMTs were investigated with conductance method in this paper. Surface states with time constant of (0.09–0.12 μs were found in S-HEMTs, and electron tunneling rather than emission was deemed to be the dominant de-trapping mechanism due to the high electric field in high Al content barrier. The density of surface states evaluated in S-HEMTs was (1.02–4.67×1013 eV−1·cm−2. Al2O3 gate insulator slightly reduced the surface states, but introduced low density of new traps with time constant of (0.65–1.29 μs into MOS-HEMTs.

  14. Investigation of trap states in high Al content AlGaN/GaN high electron mobility transistors by frequency dependent capacitance and conductance analysis

    Science.gov (United States)

    Zhu, Jie-Jie; Ma, Xiao-Hua; Hou, Bin; Chen, Wei-Wei; Hao, Yue

    2014-03-01

    Trap states in Al0.55Ga0.45N/GaN Schottky-gate high-electron-mobility transistors (S-HEMTs) and Al2O3/Al0.55Ga0.45N/GaN metal-oxide-semiconductor HEMTs (MOS-HEMTs) were investigated with conductance method in this paper. Surface states with time constant of (0.09-0.12) μs were found in S-HEMTs, and electron tunneling rather than emission was deemed to be the dominant de-trapping mechanism due to the high electric field in high Al content barrier. The density of surface states evaluated in S-HEMTs was (1.02-4.67)×1013 eV-1.cm-2. Al2O3 gate insulator slightly reduced the surface states, but introduced low density of new traps with time constant of (0.65-1.29) μs into MOS-HEMTs.

  15. Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates.

    Science.gov (United States)

    Gomez-Rodriguez, Julio; Kraus, Zachary J; Schwartzberg, Pamela L

    2011-06-01

    Developing thymocytes and T cells express the Tec kinases Itk, Rlk/Txk and Tec, which are critical modulators of T-cell receptor signaling, required for full activation of phospholipase Cγ, and downstream Ca(2+) and ERK-mediated signaling pathways. Over the last 10 years, data have implicated the Tec family kinases Itk and Rlk/Txk as important regulators of cytokine production by CD4(+) effector T-cell populations. Emerging data now suggest that the Tec family kinases not only influence cytokine-producing T-cell populations in the periphery, but also regulate the development of distinct innate-type cytokine-producing T-cell populations in the thymus. Together, these results suggest that the Tec family kinases play critical roles in helping shape immune responses via their effects on the differentiation and function of distinct cytokine-producing, effector T-cell populations. Journal compilation © 2011 FEBS. No claim to original US government works.

  16. Validation of foF2 and TEC Modeling During Geomagnetic Disturbed Times: Preliminary Outcomes of International Forum for Space Weather Modeling Capabilities Assessment

    Science.gov (United States)

    Shim, J. S.; Tsagouri, I.; Goncharenko, L. P.; Kuznetsova, M. M.

    2017-12-01

    To address challenges of assessment of space weather modeling capabilities, the CCMC (Community Coordinated Modeling Center) is leading the newly established "International Forum for Space Weather Modeling Capabilities Assessment." This presentation will focus on preliminary outcomes of the International Forum on validation of modeled foF2 and TEC during geomagnetic storms. We investigate the ionospheric response to 2013 Mar. geomagnetic storm event using ionosonde and GPS TEC observations in North American and European sectors. To quantify storm impacts on foF2 and TEC, we first quantify quiet-time variations of foF2 and TEC (e.g., the median and the average of the five quietest days for the 30 days during quiet conditions). It appears that the quiet time variation of foF2 and TEC are about 10% and 20-30%, respectively. Therefore, to quantify storm impact, we focus on foF2 and TEC changes during the storm main phase larger than 20% and 50%, respectively, compared to 30-day median. We find that in European sector, both foF2 and TEC response to the storm are mainly positive phase with foF2 increase of up to 100% and TEC increase of 150%. In North America sector, however, foF2 shows negative effects (up to about 50% decrease), while TEC shows positive response (the largest increase is about 200%). To assess modeling capability of reproducing the changes of foF2 and TEC due to the storm, we use various model simulations, which are obtained from empirical, physics-based, and data assimilation models. The performance of each model depends on the selected metrics, therefore, only one metrics is not enough to evaluate the models' predictive capabilities in capturing the storm impact. The performance of the model also varies with latitude and longitude.

  17. Thermal expansion coefficient measurement from electron diffraction of amorphous films in a TEM.

    Science.gov (United States)

    Hayashida, Misa; Cui, Kai; Malac, Marek; Egerton, Ray

    2018-05-01

    We measured the linear thermal expansion coefficients of amorphous 5-30 nm thick SiN and 17 nm thick Formvar/Carbon (F/C) films using electron diffraction in a transmission electron microscope. Positive thermal expansion coefficient (TEC) was observed in SiN but negative coefficients in the F/C films. In case of amorphous carbon (aC) films, we could not measure TEC because the diffraction radii required several hours to stabilize at a fixed temperature. Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

  18. A comparative study of TEC response for the African equatorial and mid-latitudes during storm conditions

    Czech Academy of Sciences Publication Activity Database

    Habarulema, J. B.; McKinnell, L.- A.; Burešová, Dalia; Zhang, Y.; Seemala, G.; Ngwira, Ch.; Chum, Jaroslav; Opperman, B.

    2013-01-01

    Roč. 102, Sep (2013), s. 105-114 ISSN 1364-6826 R&D Projects: GA ČR(CZ) GAP209/11/1908 Institutional support: RVO:68378289 Keywords : Magnetic storms * African equatorialandmidlatitudeTEC * dynamics * TIDs Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 1.751, year: 2013 http://www.sciencedirect.com/science/article/pii/S1364682613001545

  19. THE REDSHIFT AND NATURE OF AzTEC/COSMOS 1: A STARBURST GALAXY AT z = 4.6

    International Nuclear Information System (INIS)

    Smolcic, V.; Capak, P.; Blain, A. W.; Salvato, M.; Masters, D.; Moric, I.; Riechers, D. A.; Ilbert, O.; Aretxaga, I.; Hughes, D.; Schinnerer, E.; Sheth, K.; Aravena, M.; Aussel, H.; Aguirre, J.; Berta, S.; Carilli, C. L.; Civano, F.; Fazio, G.; Huang, J.

    2011-01-01

    Based on broadband/narrowband photometry and Keck DEIMOS spectroscopy, we report a redshift of z = 4.64 +0.06 -0.08 for AzTEC/COSMOS 1, the brightest submillimeter galaxy (SMG) in the AzTEC/COSMOS field. In addition to the COSMOS-survey X-ray to radio data, we report observations of the source with Herschel/PACS (100, 160 μm), CSO/SHARC II (350 μm), and CARMA and PdBI (3 mm). We do not detect CO(5 → 4) line emission in the covered redshift ranges, 4.56-4.76 (PdBI/CARMA) and 4.94-5.02 (CARMA). If the line is within this bandwidth, this sets 3σ upper limits on the gas mass to ∼ 9 M sun and ∼ 10 M sun , respectively (assuming similar conditions as observed in z ∼ 2 SMGs). This could be explained by a low CO-excitation in the source. Our analysis of the UV-IR spectral energy distribution of AzTEC 1 shows that it is an extremely young (∼ * ∼ 10 11 M sun ), but compact (∼ sun yr -1 . Our results imply that AzTEC 1 is forming stars in a 'gravitationally bound' regime in which gravity prohibits the formation of a superwind, leading to matter accumulation within the galaxy and further generations of star formation.

  20. 75 FR 77665 - Whirlpool Corporation, Including On-Site Leased Workers From Career Solutions TEC Staffing and...

    Science.gov (United States)

    2010-12-13

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,593] Whirlpool Corporation, Including On-Site Leased Workers From Career Solutions TEC Staffing and Andrews International, Fort Smith... subject firm. The workers are engaged in the production of refrigerators and trash compactors. The company...

  1. Using Paraffin PCM, Cryogel and TEC to Maintain Comet Surface Sample Cold from Earth Approach Through Retrieval

    Science.gov (United States)

    Choi, Michael K.

    2017-01-01

    An innovative thermal design concept to maintain comet surface samples cold (for example, 263 degrees Kelvin, 243 degrees Kelvin or 223 degrees Kelvin) from Earth approach through retrieval is presented. It uses paraffin phase change material (PCM), Cryogel insulation and thermoelectric cooler (TEC), which are commercially available.

  2. Master Teachers in Residence: Bringing a Classroom Perspective to Course Reform for NSF's Oklahoma Teacher Education Collaborative (O-TEC).

    Science.gov (United States)

    Ramsey, Sarah; Neathery, Faye; Fholer, Gwen; Weger, Elayne; Voth, Bonnie; Townsend, Joyce; Campbell, DeAnn; Boedecker, Martha

    Master teachers can be influential in course revision. The Oklahoma Teacher Education Collaborative (O-TEC) teacher reform effort is a consortium of nine higher education institutions working with the National Science Foundation's (NSF's) reform effort to produce teachers better equipped for teaching science and mathematics. The reform emphasizes…

  3. Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.

    Science.gov (United States)

    Marcotte, Douglas J; Liu, Yu-Ting; Arduini, Robert M; Hession, Catherine A; Miatkowski, Konrad; Wildes, Craig P; Cullen, Patrick F; Hong, Victor; Hopkins, Brian T; Mertsching, Elisabeth; Jenkins, Tracy J; Romanowski, Michael J; Baker, Darren P; Silvian, Laura F

    2010-03-01

    Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, plays a crucial role in B-cell maturation and mast cell activation. Although the structures of the unphosphorylated mouse BTK kinase domain and the unphosphorylated and phosphorylated kinase domains of human ITK are known, understanding the kinase selectivity profiles of BTK inhibitors has been hampered by the lack of availability of a high resolution, ligand-bound BTK structure. Here, we report the crystal structures of the human BTK kinase domain bound to either Dasatinib (BMS-354825) at 1.9 A resolution or to 4-amino-5-(4-phenoxyphenyl)-7H-pyrrolospyrimidin- 7-yl-cyclopentane at 1.6 A resolution. This data provides information relevant to the development of small molecule inhibitors targeting BTK and the TEC family of nonreceptor tyrosine kinases. Analysis of the structural differences between the TEC and Src families of kinases near the Trp-Glu-Ile motif in the N-terminal region of the kinase domain suggests a mechanism of regulation of the TEC family members.

  4. X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase.

    Science.gov (United States)

    Muckelbauer, Jodi; Sack, John S; Ahmed, Nazia; Burke, James; Chang, Chiehying Y; Gao, Mian; Tino, Joseph; Xie, Dianlin; Tebben, Andrew J

    2011-11-01

    Bone marrow kinase in the X chromosome, a member of the Tec family of tyrosine kinases, plays a role in both monocyte/macrophage trafficking as well as cytokine secretion. Although the structures of Tec family kinases Bruton's tyrosine kinase and IL-2-inducible T-cell kinase are known, the crystal structures of other Tec family kinases have remained elusive. We report the X-ray crystal structures of bone marrow kinase in the X chromosome in complex with dasatinib at 2.4 Å resolution and PP2 at 1.9 Å resolution. The bone marrow kinase in the X chromosome structures reveal a typical kinase protein fold; with well-ordered protein conformation that includes an open/extended activation loop and a stabilized DFG-motif rendering the kinase in an inactive conformation. Dasatinib and PP2 bind to bone marrow kinase in the X chromosome in the ATP binding pocket and display similar binding modes to that observed in other Tec and Src protein kinases. The bone marrow kinase in the X chromosome structures identify conformational elements of the DFG-motif that could potentially be utilized to design potent and/or selective bone marrow kinase in the X chromosome inhibitors. © 2011 John Wiley & Sons A/S.

  5. Hierarchical Bayesian modeling of ionospheric TEC disturbances as non-stationary processes

    Science.gov (United States)

    Seid, Abdu Mohammed; Berhane, Tesfahun; Roininen, Lassi; Nigussie, Melessew

    2018-03-01

    We model regular and irregular variation of ionospheric total electron content as stationary and non-stationary processes, respectively. We apply the method developed to SCINDA GPS data set observed at Bahir Dar, Ethiopia (11.6 °N, 37.4 °E) . We use hierarchical Bayesian inversion with Gaussian Markov random process priors, and we model the prior parameters in the hyperprior. We use Matérn priors via stochastic partial differential equations, and use scaled Inv -χ2 hyperpriors for the hyperparameters. For drawing posterior estimates, we use Markov Chain Monte Carlo methods: Gibbs sampling and Metropolis-within-Gibbs for parameter and hyperparameter estimations, respectively. This allows us to quantify model parameter estimation uncertainties as well. We demonstrate the applicability of the method proposed using a synthetic test case. Finally, we apply the method to real GPS data set, which we decompose to regular and irregular variation components. The result shows that the approach can be used as an accurate ionospheric disturbance characterization technique that quantifies the total electron content variability with corresponding error uncertainties.

  6. NuTEC annual report. April 1, 1997 - March 31, 1998

    International Nuclear Information System (INIS)

    1998-11-01

    This annual report summarizes the educational works carried out at the Nuclear Technology and Education Center (NuTEC) of Japan Atomic Energy Research Institute during the 1997 fiscal year. It covers all the educational courses provided at Tokyo and Tokai Education Centers and the activities of the International Technology Transfer Division, together with the R and D works for improving the educational programs, and related management works. During the 1997 fiscal year, Tokyo and Tokai Education Centers accomplished all the planned courses, both domestic and international. Total number of the trainees during the year was 1,411. The International Technology Transfer Division proceeded the preparation works of the international training courses, particularly the Asia-Pacific Nuclear Cooperation Program. In addition, various research and development efforts were made to establish new items in educational programs. (author)

  7. Use of GPS TEC Maps for Calibrating Single Band VLBI Sessions

    Science.gov (United States)

    Gordon, David

    2010-01-01

    GPS TEC ionosphere maps were first applied to a series of K and Q band VLBA astrometry sessions to try to eliminate a declination bias in estimated source positions. Their usage has been expanded to calibrate X-band only VLBI observations as well. At K-band, approx.60% of the declination bias appears to be removed with the application of GPS ionosphere calibrations. At X-band however, it appears that up to 90% or more of the declination bias is removed, with a corresponding increase in RA and declination uncertainties of approx.0.5 mas. GPS ionosphere calibrations may be very useful for improving the estimated positions of the X-only and S-only sources in the VCS and RDV sessions.

  8. NuTEC annual report. April 1, 1999 - March 31, 2000

    International Nuclear Information System (INIS)

    2000-11-01

    This report summarizes the educational activities and related management of the Nuclear Technology and Education Center (NuTEC) during the 1999 fiscal year. Both Tokyo and Tokai Education Centers have conducted almost all the planned domestic and international training courses successfully. In addition the latter Center has introduced a new course to educate senior specialists for nuclear emergency preparedness in response to the legal amendment after the criticality accident. The total number of participants was 1,122. The International Technology Transfer Division has not only planned and organized the international training courses, but also taken charge of the first seminar on Human Resource Development in Nuclear Field in Asian Region. Furthermore, various researches have been made to improve the educational programs. (author)

  9. NuTEC annual report (April 1, 2000 - March 31, 2001)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-10-01

    This report summarizes the educational activities and related management of the Nuclear Technology and Education Center (NuTEC) during the 1999 fiscal year. Both Tokyo and Tokai Education Centers have successfully conducted almost all the planned domestic and international training courses. In addition Tokai Education Center has performed the 2nd nuclear supervisor training course and introduced a new course for special nuclear emergency preparedness in response to the legal amendment after the criticality accident. The sum total number of participants was 1,397. The International Technology Transfer Division has not only planned and organized the international training courses, but also taken charge of the 2nd workshop on Human Resource Development in Nuclear Field in Asian Region. Furthermore, various researches have been made to improve the educational programs. (author)

  10. NuTEC annual report. April 1, 1998 - March 31, 1999

    International Nuclear Information System (INIS)

    1999-11-01

    This annual report summarizes the educational work carried out at the Nuclear Technology and Education Center (NuTEC) of Japan Atomic Energy Research Institute during the 1998 fiscal year. It describes all the training courses provided at Tokyo and Tokai Education Centers and the activities of the International Technology Transfer Division, together with the R and D achievements for improving the educational programs and related management work. During this fiscal year, Tokyo and Tokai Education Centers accomplished all the planned courses, both domestic and international, where the total number of the participants was 1,156. The International Technology Transfer Division conducted successfully the international training courses, including those of the Asia-Pacific Nuclear Cooperation Program. In addition, various research efforts were made to develop new items for the educational programs. (author)

  11. In vitro generation of a scaffold-free tissue-engineered construct (TEC) derived from human synovial mesenchymal stem cells: biological and mechanical properties and further chondrogenic potential.

    Science.gov (United States)

    Ando, Wataru; Tateishi, Kosuke; Katakai, Daisuke; Hart, David A; Higuchi, Chikahisa; Nakata, Ken; Hashimoto, Jun; Fujie, Hiromichi; Shino, Konsei; Yoshikawa, Hideki; Nakamura, Norimasa

    2008-12-01

    The purpose of this study was to characterize a tissue-engineered construct (TEC) generated with human synovial mesenchymal stem cells (MSCs). MSCs were cultured in medium with ascorbic acid 2-phosphate (Asc-2P) and were subsequently detached from the substratum. The detached cell/matrix complex spontaneously contracted to develop a basic TEC. The volume of the TEC assessed by varying initial cell density showed that it was proportional to initial cell densities up to 4 x 10(5) cells/cm(2). Assessment of the mechanical properties of TEC using a custom device showed that the load at failure and stiffness of the constructs significantly increased with time of culture in the presence of Asc-2P, while in the absence of Asc-2P, the constructs were mechanically weak. Thus, the basic TEC possesses sufficiently self-supporting mechanical properties in spite of not containing artificial scaffolding. TEC further cultured in chondrogenic media exhibited positive alcian blue staining with elevated expression of chondrogenic marker genes. Based on these findings, such human TEC may be a promising method to promote cartilage repair for future clinical application.

  12. Chemotherapy for endometrial carcinoma (GOGO-EM1 study): TEC (paclitaxel, epirubicin, and carboplatin) is an effective remission-induction and adjuvant therapy.

    Science.gov (United States)

    Egawa-Takata, Tomomi; Ueda, Yutaka; Kuragaki, Chie; Miyake, Takahito; Miyatake, Takashi; Fujita, Masami; Yoshino, Kiyoshi; Nakashima, Ryuichi; Okazawa, Mika; Tsutsui, Tateki; Morishige, Ken-Ichirou; Kimura, Tadashi; Yamasaki, Masato; Nishizaki, Takamichi; Nagamatsu, Masaaki; Ito, Kimihiko; Asada, Masahiro; Ogita, Kazuhide; Wakimoto, Akinori; Yamamoto, Toshiya; Nishio, Yukihiro; Enomoto, Takayuki

    2011-12-01

    TAP chemotherapy (paclitaxel, doxorubicin, and cisplatin) is effective for advanced and recurrent endometrial carcinoma, but has occasional severe toxicity. TEC chemotherapy (paclitaxel, epirubicin, and carboplatin) has been suggested to have less toxicity; however, the optimal dosage has yet to be determined. Phase I/II prospective study for TEC therapy was performed. A retrospective comparison of the prognosis between adjuvant TEC therapy and radiation for completely resected cases with risk factors was also performed. The recommended dose of TEC therapy was determined to be paclitaxel 150 mg/m(2), epirubicin 50 mg/m(2), and carboplatin AUC 4. A TEC regimen at this dose level was shown to be tolerable. The response rate and median overall survival were 74% and 37 months for those with advanced primary disease (Group B) and 50% and 26 months for recurrent tumors (Group C), respectively. A retrospective comparison showed that adjuvant TEC therapy for completely resected stage III cases improved their prognosis when compared to an adjuvant radiation therapy. TEC therapy was demonstrated to be a tolerable and effective treatment, not only as a remission-induction therapy for advanced and recurrent endometrial carcinomas but also as the adjuvant therapy.

  13. Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

    Directory of Open Access Journals (Sweden)

    Nikita Chopra

    2016-03-01

    Full Text Available Bruton's tyrosine kinase (Btk is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA. Our previous findings showed that the Tec kinases are allosterically activated by the adjacent N-terminal linker. A single tryptophan residue in the N-terminal 17-residue linker mediates allosteric activation, and its mutation to alanine leads to the complete loss of activity. Guided by hydrogen/deuterium exchange mass spectrometry results, we have employed Molecular Dynamics simulations, Principal Component Analysis, Community Analysis and measures of node centrality to understand the details of how a single tryptophan mediates allostery in Btk. A specific tryptophan side chain rotamer promotes the functional dynamic allostery by inducing coordinated motions that spread across the kinase domain. Either a shift in the rotamer population, or a loss of the tryptophan side chain by mutation, drastically changes the coordinated motions and dynamically isolates catalytically important regions of the kinase domain. This work also identifies a new set of residues in the Btk kinase domain with high node centrality values indicating their importance in transmission of dynamics essential for kinase activation. Structurally, these node residues appear in both lobes of the kinase domain. In the N-lobe, high centrality residues wrap around the ATP binding pocket connecting previously described Catalytic-spine residues. In the C-lobe, two high centrality node residues connect the base of the R- and C-spines on the αF-helix. We suggest that the bridging residues that connect the catalytic and regulatory architecture within the kinase domain may be a crucial element in transmitting information about regulatory spine assembly to the catalytic machinery of the catalytic spine and active site.

  14. Dynamics of the Tec-family tyrosine kinase SH3 domains.

    Science.gov (United States)

    Roberts, Justin M; Tarafdar, Sreya; Joseph, Raji E; Andreotti, Amy H; Smithgall, Thomas E; Engen, John R; Wales, Thomas E

    2016-04-01

    The Src Homology 3 (SH3) domain is an important regulatory domain found in many signaling proteins. X-ray crystallography and NMR structures of SH3 domains are generally conserved but other studies indicate that protein flexibility and dynamics are not. We previously reported that based on hydrogen exchange mass spectrometry (HX MS) studies, there is variable flexibility and dynamics among the SH3 domains of the Src-family tyrosine kinases and related proteins. Here we have extended our studies to the SH3 domains of the Tec family tyrosine kinases (Itk, Btk, Tec, Txk, Bmx). The SH3 domains of members of this family augment the variety in dynamics observed in previous SH3 domains. Txk and Bmx SH3 were found to be highly dynamic in solution by HX MS and Bmx was unstructured by NMR. Itk and Btk SH3 underwent a clear EX1 cooperative unfolding event, which was localized using pepsin digestion and mass spectrometry after hydrogen exchange labeling. The unfolding was localized to peptide regions that had been previously identified in the Src-family and related protein SH3 domains, yet the kinetics of unfolding were not. Sequence alignment does not provide an easy explanation for the observed dynamics behavior, yet the similarity of location of EX1 unfolding suggests that higher-order structural properties may play a role. While the exact reason for such dynamics is not clear, such motions can be exploited in intra- and intermolecular binding assays of proteins containing the domains. © 2016 The Protein Society.

  15. Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.

    Science.gov (United States)

    Chopra, Nikita; Wales, Thomas E; Joseph, Raji E; Boyken, Scott E; Engen, John R; Jernigan, Robert L; Andreotti, Amy H

    2016-03-01

    Bruton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec kinases are allosterically activated by the adjacent N-terminal linker. A single tryptophan residue in the N-terminal 17-residue linker mediates allosteric activation, and its mutation to alanine leads to the complete loss of activity. Guided by hydrogen/deuterium exchange mass spectrometry results, we have employed Molecular Dynamics simulations, Principal Component Analysis, Community Analysis and measures of node centrality to understand the details of how a single tryptophan mediates allostery in Btk. A specific tryptophan side chain rotamer promotes the functional dynamic allostery by inducing coordinated motions that spread across the kinase domain. Either a shift in the rotamer population, or a loss of the tryptophan side chain by mutation, drastically changes the coordinated motions and dynamically isolates catalytically important regions of the kinase domain. This work also identifies a new set of residues in the Btk kinase domain with high node centrality values indicating their importance in transmission of dynamics essential for kinase activation. Structurally, these node residues appear in both lobes of the kinase domain. In the N-lobe, high centrality residues wrap around the ATP binding pocket connecting previously described Catalytic-spine residues. In the C-lobe, two high centrality node residues connect the base of the R- and C-spines on the αF-helix. We suggest that the bridging residues that connect the catalytic and regulatory architecture within the kinase domain may be a crucial element in transmitting information about regulatory spine assembly to the catalytic machinery of the catalytic spine and active site.

  16. Analysis of the dislocation content in a deformed Co-based superalloy by transmission electron microscopy and X-ray diffraction

    International Nuclear Information System (INIS)

    Breuer, D.; Klimanek, P.; Muehle, U.; Martin, U.

    1997-01-01

    The present paper compares the dislocation densities as determined in a Co-based superalloy (CoNi22Cr22W14) after creep and tensile deformation by Transmission Electron Microscopy (TEM) and X-ray profile analysis (XRD). After creep tests the dislocation densities obtained by both methods are in good agreement, which is the result of a nearly homogeneous dislocation distribution. The relationship between the dislocation density and the flow stress meets the Taylor equation. After tensile deformation the dislocation densities determined by TEM and XRD differ systematically from each other, but in both cases also a Taylor relationship can be obtained. The constant α of the dislocation interaction derived by TEM is much larger than in the creep tests and also than that of the XRD, which agrees well with the creep data. The difference between the TEM and the XRD results is the consequence of the dislocation cell structure much more developed in the tensile specimens, which leads to an underestimation of the dislocation density in TEM because of overweighting the cell interior. By fitting the Fourier coefficients of the X-ray diffraction line shapes with a bimodal distribution of the defect content (composite model), dislocation densities of the cell interior can be estimated that correspond well to the TEM data. (orig.)

  17. ENSINO TÉCNICO PROFISSIONALIZANTE - ESTUDO DE CASO: UMA PROPOSTA DE CURSO TÉCNICO DA REDE E-TEC BRASIL

    OpenAIRE

    Silva, Adelson de Paula; Sartori, Viviane

    2016-01-01

    The evolution of information and communication technologies (ICT) has potentialized the Distance Education. The program e-Tec Brazil Network made use of these technological contributions offering Secondary Technical Education Courses, changing the profile of the Brazilian professionalizing education. The aim of this study is to provide a new look for the Brazilian professional education from the Distance Education and Program e-Tec Brazil Network, the course for preparation of computer Techni...

  18. The TFG-TEC oncoprotein induces transcriptional activation of the human β-enolase gene via chromatin modification of the promoter region.

    Science.gov (United States)

    Kim, Ah-Young; Lim, Bobae; Choi, JeeHyun; Kim, Jungho

    2016-10-01

    Recurrent chromosome translocations are the hallmark of many human cancers. A proportion of human extraskeletal myxoid chondrosarcomas (EMCs) are associated with the characteristic chromosomal translocation t(3;9)(q11-12;q22), which results in the formation of a chimeric protein in which the N-terminal domain of the TRK-fused gene (TFG) is fused to the translocated in extraskeletal chondrosarcoma (TEC; also called CHN, CSMF, MINOR, NOR1, and NR4A3) gene. The oncogenic effect of this translocation may be due to the higher transactivation ability of the TFG-TEC chimeric protein; however, downstream target genes of TFG-TEC have not yet been identified. The results presented here, demonstrate that TFG-TEC activates the human β-enolase promoter. EMSAs, ChIP assays, and luciferase reporter assays revealed that TFG-TEC upregulates β-enolase transcription by binding to two NGFI-B response element motifs located upstream of the putative transcription start site. In addition, northern blot, quantitative real-time PCR, and Western blot analyses showed that overexpression of TFG-TEC up-regulated β-enolase mRNA and protein expression in cultured cell lines. Finally, ChIP analyses revealed that TFG-TEC controls the activity of the endogenous β-enolase promoter by promoting histone H3 acetylation. Overall, the results presented here indicate that TFG-TEC triggers a regulatory gene hierarchy implicated in cancer cell metabolism. This finding may aid the development of new therapeutic strategies for the treatment of human EMCs. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  19. A method for separating seismo-ionospheric TEC outliers from heliogeomagnetic disturbances by using nu-SVR

    Energy Technology Data Exchange (ETDEWEB)

    Pattisahusiwa, Asis [Bandung Institute of Technology (Indonesia); Liong, The Houw; Purqon, Acep [Earth physics and complex systems research group, Bandung Institute of Technology (Indonesia)

    2015-09-30

    Seismo-Ionospheric is a study of ionosphere disturbances associated with seismic activities. In many previous researches, heliogeomagnetic or strong earthquake activities can caused the disturbances in the ionosphere. However, it is difficult to separate these disturbances based on related sources. In this research, we proposed a method to separate these disturbances/outliers by using nu-SVR with the world-wide GPS data. TEC data related to the 26th December 2004 Sumatra and the 11th March 2011 Honshu earthquakes had been analyzed. After analyzed TEC data in several location around the earthquake epicenter and compared with geomagnetic data, the method shows a good result in the average to detect the source of these outliers. This method is promising to use in the future research.

  20. A method for separating seismo-ionospheric TEC outliers from heliogeomagnetic disturbances by using nu-SVR

    International Nuclear Information System (INIS)

    Pattisahusiwa, Asis; Liong, The Houw; Purqon, Acep

    2015-01-01

    Seismo-Ionospheric is a study of ionosphere disturbances associated with seismic activities. In many previous researches, heliogeomagnetic or strong earthquake activities can caused the disturbances in the ionosphere. However, it is difficult to separate these disturbances based on related sources. In this research, we proposed a method to separate these disturbances/outliers by using nu-SVR with the world-wide GPS data. TEC data related to the 26th December 2004 Sumatra and the 11th March 2011 Honshu earthquakes had been analyzed. After analyzed TEC data in several location around the earthquake epicenter and compared with geomagnetic data, the method shows a good result in the average to detect the source of these outliers. This method is promising to use in the future research

  1. Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils.

    Science.gov (United States)

    Himpe, E; Abdul Rahim, S A; Verdood, P; Mano, H; Kooijman, R

    2013-03-01

    Previously, we showed that the phosphatidylinositol-3 kinase (PI(3)K) pathway mediates the anti-apoptotic effects of IGF-I in human neutrophils independently of its down-stream target Akt. In this study, we investigated whether IGF-I regulates Tec kinase, an alternative down-stream target of PI(3)K, in neutrophils and whether this molecule is able to affect apoptosis. We investigated the translocation of Tec kinases in neutrophils after stimulation with IGF-I. Furthermore, we transiently and stably transfected Hek293T cells with constructs expressing different forms of Tec kinase and measured the level of cell survival and apoptosis/necrosis through trypan blue exclusion test and Annexin-V/propidium iodide labelling, respectively. We show that IGF-I stimulates the translocation of Tec kinase to the membrane in neutrophils in a PI(3)K dependent matter. Overexpression of Tec kinase augments cell survival by inhibition of necrosis. The pro-survival effect is attenuated by the deletion of the kinase domain but not by inactivation of this domain by a single amino acid substitution. Tec kinase can act as a prosurvival factor and is regulated by IGF-I in human neutrophils through PI(3)K activation. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. Aspectos Fundamentales en la rehabilitación post tec en el paciente adulto y pediátrico

    Directory of Open Access Journals (Sweden)

    Dr. A. Claudio Soto

    2014-03-01

    Full Text Available El traumatismo encéfalo craneano (TEC es una entidad compleja y heterogénea, que compromete principalmente a adultos jóvenes en etapas productivas de la vida, transformándose en un problema crítico de salud pública y socio-económico en todo el mundo. Los pacientes que sobreviven a un TEC como consecuencia presentan alteraciones funcionales secundarias a un trastorno cognitivo, motor y conductual, que generan una restricción a la participación en las actividades de la vida diaria y en su reintegro familiar, social y laboral competitivo, conduciendo a una sobrecarga en los cuidados de su entorno. La rehabilitación en el TEC debe ser temprana, multidisciplinaria, intensiva, centrada en el paciente y multidimensional, considerando los aspectos motores, cognitivos, cognitivo comunicativos, alteraciones de la deglución y conductuales como elementos centrales, teniendo como objetivo final el reintegro a la comunidad y eventualmente al mundo laboral competitivo.

  3. Comparative Analysis of Various Aspects of Plateletpheresis on the Fenwal Amicus and Fresenius COM.TEC Cell Separator Instruments.

    Science.gov (United States)

    Philip, Joseph; Biswas, Amit Kumar; Chatterjee, Tathagata; Mallhi, Rajiv Singh

    2014-01-01

    To compare the Fenwal Amicus and the Fresenius COM.TEC apheresis instruments regarding donor peripheral blood parameters, operational variables of the instruments, and quality control parameters of the product obtained. We performed 100 platelet collections from 100 voluntary donors using the 2 studied devices. We measured platelet count using an automated analyzer and analyzed the activation statuses using a flow cytometer. The median time needed to perform the procedures was significantly longer with the COM.TEC. However, the product we obtained using the Amicus instrument showed higher degrees of platelet-activation. All products we obtained with both instruments had white blood cell counts of less than 5 × 10(6) per bag. We observed no statistical difference regarding collection efficiency and collection rates between the devices. Both instruments collected platelets efficiently, with minimal donor discomfort. Compared with the COM.TEC instrument, the Amicus reached the platelet target yield more quickly; however, it displayed an increase in platelet activation. Copyright© by the American Society for Clinical Pathology (ASCP).

  4. The Electronic Health Literacy and Utilization of Technology for Health in a Remote Hawaiian Community: Lana'i.

    Science.gov (United States)

    Witten, Nash Ak; Humphry, Joseph

    2018-03-01

    The Lana'i Community Health Center (LCHC) like other health care organizations, is striving to implement technology-enabled care (TEC) in the clinical setting. TEC includes such technological innovations as patient portals, mobile phone applications, wearable health sensors, and telehealth. This study examines the utilization of communication technology by members of the Lana'i community and LCHC staff and board members in the home and in their daily lives and evaluates the community's electronic health literacy. Quantitative surveys and qualitative focus groups were utilized. These revealed that members of the Lana'i community and LCHC staff and board members regularly utilize technology, in the form of smart cell phones, WiFi, and internet texting. This community has integrated technology into their daily lives, even though they live on an isolated island with 3,102 people; however, despite this integration, the electronic health literacy of this population appears insufficient for proper understanding and utilization of TEC, limiting the potential of patient portals or remote monitoring of patient generated data for chronic disease prevention and management without additional education and mentoring. It is therefore in the best interest of the LCHC and other health organizations wishing to implement TEC in a rural community such as Lana'i to include a strong educational component with use of TEC, and perhaps establish a mentor/partnership program for the highly-challenged patient.

  5. Low latitude ionospheric TEC responses to dynamical complexity quantifiers during transient events over Nigeria

    Science.gov (United States)

    Ogunsua, Babalola

    2018-04-01

    In this study, the values of chaoticity and dynamical complexity parameters for some selected storm periods in the year 2011 and 2012 have been computed. This was done using detrended TEC data sets measured from Birnin-Kebbi, Torro and Enugu global positioning system (GPS) receiver stations in Nigeria. It was observed that the significance of difference (SD) values were mostly greater than 1.96 but surprisingly lower than 1.96 in September 29, 2011. The values of the computed SD were also found to be reduced in most cases just after the geomagnetic storm with immediate recovery a day after the main phase of the storm while the values of Lyapunov exponent and Tsallis entropy remains reduced due to the influence of geomagnetic storms. It was also observed that the value of Lyapunov exponent and Tsallis entropy reveals similar variation pattern during storm period in most cases. Also recorded surprisingly were lower values of these dynamical quantifiers during the solar flare event of August 8th and 9th of the year 2011. The possible mechanisms responsible for these observations were further discussed in this work. However, our observations show that the ionospheric effects of some other possible transient events other than geomagnetic storms can also be revealed by the variation of chaoticity and dynamical complexity.

  6. The ultraviolet detection component based on Te-Cs image intensifier

    Science.gov (United States)

    Qian, Yunsheng; Zhou, Xiaoyu; Wu, Yujing; Wang, Yan; Xu, Hua

    2017-05-01

    Ultraviolet detection technology has been widely focused and adopted in the fields of ultraviolet warning and corona detection for its significant value and practical meaning. The component structure of ultraviolet ICMOS, imaging driving and the photon counting algorithm are studied in this paper. Firstly, the one-inch and wide dynamic range CMOS chip with the coupling optical fiber panel is coupled to the ultraviolet image intensifier. The photocathode material in ultraviolet image intensifier is Te-Cs, which contributes to the solar blind characteristic, and the dual micro-channel plates (MCP) structure ensures the sufficient gain to achieve the single photon counting. Then, in consideration of the ultraviolet detection demand, the drive circuit of the CMOS chip is designed and the corresponding program based on Verilog language is written. According to the characteristics of ultraviolet imaging, the histogram equalization method is applied to enhance the ultraviolet image and the connected components labeling way is utilized for the ultraviolet single photon counting. Moreover, one visible light video channel is reserved in the ultraviolet ICOMS camera, which can be used for the fusion of ultraviolet and visible images. Based upon the module, the ultraviolet optical lens and the deep cut-off solar blind filter are adopted to construct the ultraviolet detector. At last, the detection experiment of the single photon signal is carried out, and the test results are given and analyzed.

  7. First assimilations of COSMIC radio occultation data into the Electron Density Assimilative Model (EDAM

    Directory of Open Access Journals (Sweden)

    M. J. Angling

    2008-02-01

    Full Text Available Ground based measurements of slant total electron content (TEC can be assimilated into ionospheric models to produce 3-D representations of ionospheric electron density. The Electron Density Assimilative Model (EDAM has been developed for this purpose. Previous tests using EDAM and ground based data have demonstrated that the information on the vertical structure of the ionosphere is limited in this type of data. The launch of the COSMIC satellite constellation provides the opportunity to use radio occultation data which has more vertical information. EDAM assimilations have been run for three time periods representing quiet, moderate and disturbed geomagnetic conditions. For each run, three data sets have been ingested – only ground based data, only COSMIC data and both ground based and COSMIC data. The results from this preliminary study show that both ground and space based data are capable of improving the representation of the vertical structure of the ionosphere. However, the analysis is limited by the incomplete deployment of the COSMIC constellation and the use of auto-scaled ionosonde data. The first of these can be addressed by repeating this type of study once full deployment has been achieved. The latter requires the manual scaling of ionosonde data; ideally an agreed data set would be scaled and made available to the community to facilitate comparative testing of assimilative models.

  8. YES, we can use CT for ionosphere…..!!

    Indian Academy of Sciences (India)

    First page Back Continue Last page Graphics. In the ionospheric context, the measured data is the Total Electron Content (TEC) which is the line integral of electron density along the propagation path. In the ionospheric context, the measured data is the Total Electron Content (TEC) which is the line integral of electron ...

  9. Journal of Earth System Science | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Total electron content (TEC) data derived from Global Positioning System satellite transmissions are used to study the effect of the flares on the ionosphere. A nonlinear significant correlation ( R 2 =0.86) has been observed between EUV enhancement (ΔEUV) and corresponding enhancement in TECTEC).

  10. Ionospheric response to X-class solar flares in the ascending half of ...

    Indian Academy of Sciences (India)

    Total electron content (TEC) data derived from Global Positioning System satellite transmissions are used to study the effect of the flares on the ionosphere. A nonlinear significant correlation ( R 2 =0.86) has been observed between EUV enhancement (ΔEUV) and corresponding enhancement in TECTEC).

  11. Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway.

    Science.gov (United States)

    Wang, Fei; Zhang, Wei; Wang, Chao; Fang, Xu; Cheng, Hao; Liu, Sheng; Chen, Xu-Lin

    2017-05-23

    Tec kinase, a prototypical member of the Tec tyrosine kinases family, was shown to mainly govern lymphocyte proliferation. In the present study, we investigated the role of Tec kinase in acute inflammatory response in lipopolysaccharide (LPS) challenge. First, we demonstrate that Tec kinase activity was observed in RAW264.7 macrophages exposed to LPS. Tec and phosphorylated Tec expression were upregulated in a dose- and time-dependent manner after LPS stimulation. LPS increased monocyte chemotactic protein (MCP)-1 secretion and intercellular adhesion molecule (ICAM)-1 expression, and increasing mRNA expression was consistently observed. LPS also induced IκBα phoshporylaytion and its degradation, increased NF-κB p65 phoshporylaytion and translocation to nuclei in RAW264.7 cells. Pretreatment with LFM-A13 decreased LPS-induced cytokines and chemokines production and mRNA levels, blocked NF-κB transactivation. These effects of LPS were also prevented by Tec-siRNA. Additionally, LFM-A13 or Tec-siRNA obviously inhibited LPS-induced TGFβ-activated kinase 1(TAK1) phosphorylation. Taken together, our results suggest that Tec kinase involves in acute inflammation process in LPS-stimulated RAW264.7 cells, at least mediated by activating TAK1/ NF-κB signal pathway.

  12. Mutational profiling of bone metastases from lung adenocarcinoma: results of a prospective study (POUMOS-TEC).

    Science.gov (United States)

    Confavreux, Cyrille B; Girard, Nicolas; Pialat, Jean-Baptiste; Bringuier, Pierre-Paul; Devouassoux-Shisheboran, Mojgan; Rousseau, Jean-Charles; Isaac, Sylvie; Thivolet-Bejui, Françoise; Clezardin, Philippe; Brevet, Marie

    2014-01-01

    Targeted therapies have improved patient survival in metastatic lung adenocarcinoma. Molecular diagnosis is a key element to identify oncogenic drivers predicting the efficacy of these agents. In stage IV patients, histopathological diagnosis is often performed on bone metastases biopsy, but routine procedure of decalcification may alter DNA quality for subsequent molecular tests. We set up a procedure to perform molecular analyses on bone metastasis and describe the results of mutational profiling. POUMOS-TEC is a prospective study conducted in stage IV lung adenocarcinomas. Bone metastasis specimens from surgery and CT-scan guided biopsies were sent fresh for immediate formalin-fixation. Decalcification was performed, only when necessary, using EDTA. Controls were processed with acid decalcification. DNA extraction was performed after laser microdissection. Mutational profiling of oncogenic drivers was conducted as recommended by the French National Cancer Institute. Diagnosis efficiency of the computed tomography (CT)-scan guided biopsy process was assessed. Among 177 collected bone metastases specimens, 49 came from lung adenocarcinomas. Specimens processed with no decalcification or EDTA (n=45) provided high-quality DNA. Molecular profiling was performed in 44/45 (98%) of cases. The results of the whole panel of oncogenic drivers (EGFR, KRAS, BRAF, PIK3CA, HER2 and ALK) were obtained in 41/45 (91%) of cases. A mutation was observed in 50% of cases including 32% of KRAS and 14% of epidermal growth factor receptor (EGFR) mutations. CT-scan biopsy efficiency rate was 96%. We demonstrated the feasibility to routinely conduct mutational profiling on bone metastases biopsies. We observed a higher rate of EGFR mutations (+42%) in comparison with the average rate of all stage IV lung adenocarcinomas. This procedure is a new step toward the goal of personalized medicine to treat lung cancers and other osteophilic tumors.

  13. The Tec kinase ITK regulates thymic expansion, emigration, and maturation of γδ NKT cells.

    Science.gov (United States)

    Yin, Catherine C; Cho, Ok Hyun; Sylvia, Katelyn E; Narayan, Kavitha; Prince, Amanda L; Evans, John W; Kang, Joonsoo; Berg, Leslie J

    2013-03-15

    The Tec family tyrosine kinase, Itk, regulates signaling downstream of the TCR. The absence of Itk in CD4(+) T cells results in impaired Th2 responses along with defects in maturation, cytokine production, and survival of iNKT cells. Paradoxically, Itk(-/-) mice have spontaneously elevated serum IgE levels, resulting from an expansion of the Vγ1.1(+)Vδ6.3(+) subset of γδ T cells, known as γδ NKT cells. Comparisons between γδ NKT cells and αβ iNKT cells showed convergence in the pattern of cell surface marker expression, cytokine profiles, and gene expression, suggesting that these two subsets of NKT cells undergo similar differentiation programs. Hepatic γδ NKT cells have an invariant TCR and are derived predominantly from fetal progenitors that expand in the thymus during the first weeks of life. The adult thymus contains these invariant γδ NKT cells plus a heterogeneous population of Vγ1.1(+)Vδ6.3(+) T cells with diverse CDR3 sequences. This latter population, normally excluded from the liver, escapes the thymus and homes to the liver when Itk is absent. In addition, Itk(-/-) γδ NKT cells persistently express high levels of Zbtb16 (PLZF) and Il4, genes that are normally downregulated in the most mature subsets of NKT cells. These data indicate that Itk signaling is required to prevent the expansion of γδ NKT cells in the adult thymus, to block their emigration, and to promote terminal NKT cell maturation.

  14. Electronic delivery of alternative contents in cinemas before the digital era: the case of theater television in the US exhibition market in the 1940s and 1950s

    Directory of Open Access Journals (Sweden)

    Kira Kitsopanidou

    2012-08-01

    strategies of the 1950s and 20th Century-Fox’s vision of the possibilities of electronic delivery for motion picture exhibition. This paper aims to shed more light in one of the less known chapters of the history of motion picture presentation in the US, whose renewed interest today is closely linked to the digital media revolution. As the exhibition market transitions to digital delivery, the deployment of alternative contents, including gaming, sporting events and concerts, is converting the cinema screen into a multimedia center, a giant high definition television screen. How far is this idea from the theater television concept of the 1950s which Spyros Skouras qualified as “the greatest stimulant our industry has had since the advent of sound” ?

  15. Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion.

    Science.gov (United States)

    Vanova, Tereza; Konecna, Zaneta; Zbonakova, Zuzana; La Venuta, Giuseppe; Zoufalova, Karolina; Jelinkova, Sarka; Varecha, Miroslav; Rotrekl, Vladimir; Krejci, Pavel; Nickel, Walter; Dvorak, Petr; Kunova Bosakova, Michaela

    2017-09-01

    Human pluripotent stem cells (hPSC) require signaling provided by fibroblast growth factor (FGF) receptors. This can be initiated by the recombinant FGF2 ligand supplied exogenously, but hPSC further support their niche by secretion of endogenous FGF2. In this study, we describe a role of tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase in this process. We show that TEC-mediated FGF2 secretion is essential for hPSC self-renewal, and its lack mediates specific differentiation. Following both short hairpin RNA- and small interfering RNA-mediated TEC knockdown, hPSC secretes less FGF2. This impairs hPSC proliferation that can be rescued by increasing amounts of recombinant FGF2. TEC downregulation further leads to a lower expression of the pluripotency markers, an improved priming towards neuroectodermal lineage, and a failure to develop cardiac mesoderm. Our data thus demonstrate that TEC is yet another regulator of FGF2-mediated hPSC pluripotency and differentiation. Stem Cells 2017;35:2050-2059. © 2017 AlphaMed Press.

  16. In-air thermal imaging comparison of Legacy AdvanTec, Millennium, and Sovereign WhiteStar phacoemulsification systems.

    Science.gov (United States)

    Olson, Michael D; Miller, Kevin M

    2005-08-01

    To compare the temperature profiles of 3 popular phacoemulsification units (Alcon Legacy AdvanTec, Bausch & Lomb Millennium, and AMO Sovereign WhiteStar) under similar operating conditions in air. Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA. Phacoemulsification probes from the 3 units were placed side by side in air and imaged in the infrared region using model P60 ThermaCAM (Flir Systems). The highest temperature produced by each probe was measured 10 seconds and 30 seconds after power application. Testing was performed under conditions that might produce a corneal burn during cataract surgery. Irrigation flow was set at the low rate of 1 cc/min to simulate a tight incision. Aspiration flow was set at 0 cc/min to simulate occlusion of the needle lumen. Wound compression was simulated in some tests by suspending 22.6 g weights by rubber bands from the silicone sleeves. Manufacturers' specific and identical silicone sleeves were used to evaluate possible variations in thermal conductivity. The AdvanTec Legacy and Millennium were operated in pulse mode at 15 Hertz; 50% duty cycle; and 10%, 30%, and 50% power. The Sovereign WhiteStar was operated in both C/F (56 Hz, 33% duty cycle) and C/L (33 Hz, 20% duty cycle) modes at the same console power settings. Temperature profiles were determined at a variety of power settings with each system operating in continuous and pulse mode. Under all experimental conditions (at 10%, 30%, and 50% powers; with and without external weights suspended from the phacoemulsification probes; with manufacturers' and identical silicone sleeves; and in continuous and pulse modes), the Millennium and the Sovereign WhiteStar generated higher temperatures than the Legacy AdvanTec. Under controlled operating conditions in air and under a variety of power, load, and duty-cycle settings, the Millennium and the Sovereign WhiteStar, operating in both pulse and

  17. Agonistic anti-CD40 promotes early development and increases the incidence of severe thyroid epithelial cell hyperplasia (TEC H/P) in CD4−/− mice

    Science.gov (United States)

    Yu, Shiguang; Downey, Edward F; Braley-Mullen, Helen

    2013-01-01

    IFN-γ−/−NOD.H-2h4 mice develop thyroid epithelial cell hyperplasia (TEC H/P) characterised by abnormal proliferation of thyrocytes and infiltration of thyroids by CD4+ and CD8+ T cells, macrophages and dendritic cells. CD8+ T cells from mice with severe TEC H/P transfer similar lesions to SCID recipients, whereas CD4+ T cells transfer mild TEC H/P. CD4− and CD8− deficient IFN-γ−/−NOD.H-2h4 mice were generated to determine if CD4+ T cells were required for initial activation of the CD8+ T cells that transfer TEC H/P. After 6–8 months on NaI water, only 2 of 60 CD8−/− mice developed severe TEC H/P, whereas 31 of 101 CD4−/− mice developed severe TEC H/P and fibrosis comparable in severity to that of IFN-γ−/− mice. However, splenocytes from CD4−/− mice with severe TEC H/P did not effectively transfer severe TEC H/P to SCID recipients. When CD4−/− donors were given agonistic anti-CD40 mAb, most developed severe TEC H/P and their cells transferred severe TEC H/P to SCID recipients. These results indicate that agonistic anti-CD40 can provide an important signal for activation of autoreactive CD8+ T cells that transfer severe TEC H/P. Therefore, targeting or blocking CD40 could provide effective therapy for diseases involving hyperplasia and fibrosis mediated by CD8+ T cells. PMID:25400914

  18. An anomaly of positron parameter appearing in the study of an electron-brush-plated material -- Is it possible to use positron to detect molecular hydrogen content

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jingcheng; Qin Yunjie (Shanghai Iron and Steel Research Inst. (China). Applied Physics Dept.); Zhang Guilin; Zheng Wanhui (Shanghai Nuclear Research Inst. (China))

    1994-11-01

    On account of the ease with which positron annihilation experiments may be made and the well-known manner in which positrons behave much in the way that hydrogen protons do, the positron technique is thus commonly used to study hydrogen-charging and hydrogen-absorbed metals and alloys. Indeed, the positron technique has been an indispensable and powerful tool to investigate the influence of hydrogen on microstructures and properties of materials, thus a lot of the related papers have been published. However, papers regarding the use of positrons to detect molecular hydrogen content are few in the literature. This is because hydrogen-charging of metallic materials is a quite complicated process. Generally speaking, when hydrogen-charging, the content of hydrogen increases but occasionally it becomes lower instead of higher with increasing charging time. In addition, positrons, after entering a material, are affected not only by the old defects and the newly generated defects, but by hydrogen proton screening as well. Therefore, the existence of certain relationships between the measured positron parameter and hydrogen content in the material has not been found. Among the curves of positron parameter as a function of charging time which appeared in publications, the one which has a wavelike characteristic was frequently seen. In this letter, the author found that the measured Doppler lineshape parameter happens to be roughly directly proportional to the molecular hydrogen content involved in a particular material.

  19. Comparison of equatorial GPS-TEC observations over an African station and an American station during the minimum and ascending phases of solar cycle 24

    Directory of Open Access Journals (Sweden)

    A. O. Akala

    2013-11-01

    Full Text Available GPS-TEC data were observed at the same local time at two equatorial stations on both longitudes: Lagos (6.52° N, 3.4° E, 3.04° S magnetic latitude, Nigeria; and Pucallpa (8.38° S, 74.57° W, 4.25° N magnetic latitude, Peru during the minimum (2009, 2010 and ascending (2011 phases of solar cycle 24. These data were grouped into daily, seasonal and solar activity sets. The day-to-day variations in vertical TEC (VTEC recorded the maximum during 14:00–16:00 LT and minimum during 04:00–06:00 LT at both longitudes. Seasonally, during solar minimum, maximum VTEC values were observed during March equinox and minimum during solstices. However, during the ascending phase of the solar activity, the maximum values were recorded during the December solstice and minimum during the June solstice. VTEC also increased with solar activity at both longitudes. On longitude by longitude comparison, the African GPS station generally recorded higher VTEC values than the American GPS station. Furthermore, harmonic analysis technique was used to extract the annual and semi-annual components of the amplitudes of the TEC series at both stations. The semi-annual variations dominated the TEC series over the African equatorial station, while the annual variations dominated those over the American equatorial station. The GPS-TEC-derived averages for non-storm days were compared with the corresponding values derived by the IRI-2007 with the NeQuick topside option. The NeQuick option of IRI-2007 showed better performance at the American sector than the African sector, but generally underestimating TEC during the early morning hours at both longitudes.

  20. Ionospheric perturbations due to earthquakes as determined from VLF and GPS-TEC data analysis at Agra, India

    Science.gov (United States)

    Singh, Dhananjali; Singh, Birbal; Pundhir, Devbrat

    2018-04-01

    Employing SoftPAL receiver, amplitude variations of VLF transmitter signals NWC (19.8 kHz) and NPM (21.4 kHz) are analyzed at Agra station in India (Geograph. lat. 27.2°N, long. 78°E) ±15 days from five major earthquakes of magnitude M = 6.9-8.5 occurred in Indian subcontinent during the years 2011-2013. We apply nighttime fluctuation (NF) method and show that in almost all cases the trend decreases and dispersion and NF increase on the same days corresponding to each earthquake about 11-15 days prior to the main shock. Assuming that the ionospheric perturbations are caused by atmospheric gravity waves (AGW), we also calculate AGW modulation index for each case and find its values increased on the days amplitude fluctuations take place. Its value is decreased in one case only where the perturbations may be attributed to penetration of seismogenic electric field. In order to support the above results we also present GPS-TEC data analyzed by us corresponding to three of the above earthquakes. We study the TEC anomalies (unusual enhancements) and find that in one case the precursory period is almost the same as that found in NF method.

  1. Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.

    Science.gov (United States)

    Boyken, Scott E; Fulton, D Bruce; Andreotti, Amy H

    2012-09-01

    IL-2 inducible T-cell kinase (Itk) is a Tec family non-receptor tyrosine kinase involved in signaling downstream of the T-cell receptor. Itk contains an amino-terminal Pleckstrin Homology (PH) domain that binds phosphatidylinositol (3,4,5)-trisphosphate, recruiting Itk to the plasma membrane upon T-cell receptor activation. In addition to phosphoinositide binding, accumulating data suggest that the Itk PH domain likely mediates additional interactions outside of the phosphoinositide ligand binding pocket. The structural basis for additional PH domain functions remains elusive because of the poor recombinant expression and in vitro solution behavior of the Itk PH domain. Here, we determine that the lone α-helix in the Itk PH domain is responsible for the poor solution properties and that mutation of just two residues in the Itk α-helix to the corresponding amino acids in Btk or Tec dramatically improves the soluble recombinant expression and solution behavior of the Itk PH domain. We present this double mutant as a valuable tool to characterize the structure and function of the Itk PH domain. It is also interesting to note that the precise sites of mutation identified in this study appear as somatic mutations associated with cancerous tissue. Collectively, the findings suggest that the two helical residues in the Itk PH domain may serve an important and unique structural role in wild-type Itk that differentiates this tyrosine kinase from its related family members. Copyright © 2012 The Protein Society.

  2. The role of Tec kinase signaling pathways in the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis.

    Science.gov (United States)

    Afifiyan, N; Tillman, B; French, B A; Sweeny, O; Masouminia, M; Samadzadeh, S; French, S W

    2017-10-01

    Several research strategies have been used to study the pathogenesis of alcoholic hepatitis (AH). These strategies have shown that various signaling pathways are the target of alcohol in liver cells. However, few have provided specific mechanisms associated with Mallory-Denk Bodies (MDBs) formed in Balloon cells in AH. The formation of MDBs in these hepatocytes is an indication that the mechanisms of protein quality control have failed. The MDB is the result of aggregation and accumulation of proteins in the cytoplasm of balloon degenerated liver cells. To understand the mechanisms that failed to degrade and remove proteins in the hepatocyte from patients suffering from alcoholic hepatitis, we investigated the pathways that showed significant up regulation in the AH liver biopsies compared to normal control livers (Liu et al., 2015). Analysis of genomic profiles of AH liver biopsies and control livers by RNA-seq revealed different pathways that were up regulated significantly. In this study, the focus was on Tec kinase signaling pathways and the genes that significantly interrupt this pathway. Quantitative PCR and immunofluorescence staining results, indicated that several genes and proteins are significantly over expressed in the livers of AH patients that affect the Tec kinase signaling to PI3K which leads to activation of Akt and its downstream effectors. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

    Science.gov (United States)

    Joseph, Raji E; Kleino, Iivari; Wales, Thomas E; Xie, Qian; Fulton, D Bruce; Engen, John R; Berg, Leslie J; Andreotti, Amy H

    2013-08-27

    Itk (interleukin-2-inducible T cell kinase) and Btk (Bruton's tyrosine kinase) are nonreceptor tyrosine kinases of the Tec family that signal downstream of the T cell receptor (TCR) and B cell receptor (BCR), respectively. Despite their high sequence similarity and related signaling roles, Btk is a substantially more active kinase than Itk. We showed that substitution of 6 of the 619 amino acid residues of Itk with the corresponding residues of Btk (and vice versa) was sufficient to completely switch the activities of Itk and Btk. The substitutions responsible for the swap in activity are all localized to the activation segment of the kinase domain. Nuclear magnetic resonance and hydrogen-deuterium exchange mass spectrometry analyses revealed that Itk and Btk had distinct protein dynamics in this region, which could explain the differences in catalytic efficiency between these kinases. Introducing Itk with enhanced activity into T cells led to enhanced and prolonged TCR signaling compared to that in cells with wild-type Itk. These findings imply that evolutionary pressures have led to Tec kinases having distinct enzymatic properties, depending on the cellular context. We suggest that the weaker catalytic activities of T cell-specific kinases serve to regulate cellular activation and prevent aberrant immune responses.

  4. Polymer electronics

    CERN Document Server

    Geoghegan, Mark

    2013-01-01

    Polymer electronics is the science behind many important new developments in technology, such as the flexible electronic display (e-ink) and many new developments in transistor technology. Solar cells, light-emitting diodes, and transistors are all areas where plastic electronics is likely to, or is already having, a serious impact on our daily lives. With polymer transistors and light-emitting diodes now being commercialised, there is a clear need for a pedagogic text thatdiscusses the subject in a clear and concise fashion suitable for senior undergraduate and graduate students. The content

  5. [Transcutaneous measurement of partial pressure of carbon dioxide and oxygen saturation: validation of the SenTec monitor].

    Science.gov (United States)

    Domingo, Ch; Canturri, E; Luján, M; Moreno, A; Espuelas, H; Marín, A

    2006-05-01

    To validate a monitor for transcutaneous measurement of oxygen saturation (SpO2) and partial pressure of carbon dioxide (TcPCO2). This observational study included 140 Caucasian nonsmokers without jaundice. Patients underwent forced spirometry, measurement of SpO2 and TcPCO2 with the SenTec monitor, and arterial blood gas analysis (readings with 2 devices) during the stabilization phase of the monitor. In the statistical analysis, values from the 2 devices for measuring arterial blood gases were compared by mean differences for PaCO2 and oxygen saturation (SaO2). The arithmetic mean of the 2 blood gas measurements was calculated and relations between them and the SpO2 and TcPCO2 were assessed by the Pearson correlation coefficient (r) and the intraclass correlation coefficient (ICC) as a measure of agreement. Bland-Altman analysis was used to test data dispersion. Ten patients were excluded due to a systematic error in the gas calibrator. The mean (SD) time to stabilization of the monitor before reading was 13.9 (2.4) minutes. The forced expiratory volume in the first second was greater than 80% in 40 patients, between 60% and 79% in 23, between 40% and 59% in 30, and less than 40% in 37. The mean (SD) differences between arterial blood gas measurements were 0.28 (1.0) mm Hg for PaCO2, -0.06% (0.86%) for SaO2, and -0.9 (2.7) mm Hg for PaO2. In the tests for correlation and agreement, r was 0.74 and ICC was 0.73 for SaO2 and SpO2; r was 0.92 and ICC was 0.92 for PaCO2 and TcPCO2. The subgroup analyses did not show any noteworthy differences. The Bland Altman analysis showed no significant dispersion. It was observed that the SenTec monitor underestimated oxygen saturation values by around 1% with respect to SaO2 and overestimated carbon dioxide pressure by 1 mm Hg with respect to PaCO2 values. The stabilization time recommended for the SenTec monitor before taking a reading is 20 minutes. The overestimates and underestimates by the monitor are not clinically

  6. Simple preparation of thiol-ene particles in glycerol and surface functionalization by thiol-ene chemistry (TEC) and surface chain transfer free radical polymerization (SCT-FRP)

    DEFF Research Database (Denmark)

    Hoffmann, Christian; Chiaula, Valeria; Pinelo, Manuel

    2018-01-01

    functionalization of excess thiol groups via photochemical thiol-ene chemistry (TEC) resulting in a functional monolayer. In addition, surface chain transfer free radical polymerization (SCT-FRP) was used for the first time to introduce a thicker polymer layer on the particle surface. The application potential...

  7. Study of ionospheric precursors using GPS and GIM-TEC data related to earthquakes occurred on 16 April and 24 September, 2013 in Pakistan region

    Science.gov (United States)

    Pundhir, Devbrat; Singh, Birbal; Singh, O. P.; Gupta, Saral Kumar; Karia, S. P.; Pathak, K. N.

    2017-11-01

    In this paper, we have examined the diurnal variations of GPS-TEC observed at two Indian stations of Agra (27.2°N, 78°E) and Surat (21.16°N, 72.78°E) and global ionospheric maps data (GIM-TEC) for the months of April and September 2013 in search of ionospheric precursors of three major earthquakes (M > 6.5) that occurred in these months. The well-established quartile based statistical technique is adopted for the analysis of TEC data. The results show two kinds of anomalies, one in which simultaneous enhancements in TEC occurred in the three sets of data, 1-9 days and 3 days before the main shock in the two months respectively, and another in which anomalies occurred 15 days before in April, and 21 days before in September at Surat respectively. The depletions have also been found in three data sets but they are not significant. These anomalies are unlikely be influenced by geomagnetic parameters due to quiet magnetic conditions. The effect of also solar activity have also been considered and examined very precisely. The results are interpreted in terms of Lithosphere-Atmosphere-Ionosphere coupling (LAIC) mechanisms available in the literature.

  8. Removal of Inorganic, Microbial, and Particulate Contaminants from a Fresh Surface Water: Village Marine Tec. Expeditionary Unit Water Purifier, Generation 1

    Science.gov (United States)

    The Village Marine Tec. Generation 1 Expeditionary Unit Water Purifier (EUWP) is a mobile skid-mounted system employing ultrafiltration (UF) and reverse osmosis (RO) to produce drinking water from a variety of different water quality sources. The UF components were evaluated to t...

  9. Evaluation of an Internally Controlled Multiplex Tth Endonuclease Cleavage Loop-Mediated Isothermal Amplification (TEC-LAMP) Assay for the Detection of Bacterial Meningitis Pathogens.

    Science.gov (United States)

    Higgins, Owen; Clancy, Eoin; Cormican, Martin; Boo, Teck Wee; Cunney, Robert; Smith, Terry J

    2018-02-09

    Bacterial meningitis infection is a leading global health concern for which rapid and accurate diagnosis is essential to reduce associated morbidity and mortality. Loop-mediated isothermal amplification (LAMP) offers an effective low-cost diagnostic approach; however, multiplex LAMP is difficult to achieve, limiting its application. We have developed novel real-time multiplex LAMP technology, TEC-LAMP, using Tth endonuclease IV and a unique LAMP primer/probe. This study evaluates the analytical specificity, limit of detection (LOD) and clinical application of an internally controlled multiplex TEC-LAMP assay for detection of leading bacterial meningitis pathogens: Streptococcus pneumoniae , Neisseria meningitidis and Haemophilus influenzae . Analytical specificities were established by testing 168 bacterial strains, and LODs were determined using Probit analysis. The TEC-LAMP assay was 100% specific, with LODs for S. pneumoniae , N. meningitidis and H. influenzae of 39.5, 17.3 and 25.9 genome copies per reaction, respectively. Clinical performance was evaluated by testing 65 archived PCR-positive samples. Compared to singleplex real-time PCR, the multiplex TEC-LAMP assay demonstrated diagnostic sensitivity and specificity of 92.3% and 100%, respectively. This is the first report of a single-tube internally controlled multiplex LAMP assay for bacterial meningitis pathogen detection, and the first report of Tth endonuclease IV incorporation into nucleic acid amplification diagnostic technology.

  10. Long-time Luminescence Kinetics of Localized excitons and conduction Band Edges Smearing in ZnSe(1-c)Tec Solid Solutions

    DEFF Research Database (Denmark)

    Klochikhin, O.; Ogloblin, S. G.; Permogorov, S.

    2000-01-01

    It is shown that the integrated luminescence intensity of localized excitons in solid solutions ZnSe(1 - c)Tec has a component slowly decaying with time. After the excitation above the mobility threshold, the long-time intensity decreases exponentially, with a fractional exponent changing from...

  11. Evaluation of an Internally Controlled Multiplex Tth Endonuclease Cleavage Loop-Mediated Isothermal Amplification (TEC-LAMP Assay for the Detection of Bacterial Meningitis Pathogens

    Directory of Open Access Journals (Sweden)

    Owen Higgins

    2018-02-01

    Full Text Available Bacterial meningitis infection is a leading global health concern for which rapid and accurate diagnosis is essential to reduce associated morbidity and mortality. Loop-mediated isothermal amplification (LAMP offers an effective low-cost diagnostic approach; however, multiplex LAMP is difficult to achieve, limiting its application. We have developed novel real-time multiplex LAMP technology, TEC-LAMP, using Tth endonuclease IV and a unique LAMP primer/probe. This study evaluates the analytical specificity, limit of detection (LOD and clinical application of an internally controlled multiplex TEC-LAMP assay for detection of leading bacterial meningitis pathogens: Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae. Analytical specificities were established by testing 168 bacterial strains, and LODs were determined using Probit analysis. The TEC-LAMP assay was 100% specific, with LODs for S. pneumoniae, N. meningitidis and H. influenzae of 39.5, 17.3 and 25.9 genome copies per reaction, respectively. Clinical performance was evaluated by testing 65 archived PCR-positive samples. Compared to singleplex real-time PCR, the multiplex TEC-LAMP assay demonstrated diagnostic sensitivity and specificity of 92.3% and 100%, respectively. This is the first report of a single-tube internally controlled multiplex LAMP assay for bacterial meningitis pathogen detection, and the first report of Tth endonuclease IV incorporation into nucleic acid amplification diagnostic technology.

  12. Silicon-substituted hydroxyapatite coating with Si content on the nanotube-formed Ti–Nb–Zr alloy using electron beam-physical vapor deposition

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Yong-Hoon [Division of Restorative, Prosthetic and Primary Care Dentistry, College of Dentistry, The Ohio State University, 305 W. 12th Ave., Columbus, OH (United States); Department of Dental Materials, Research Center of Nano-Interface Activation for Biomaterials, and Research Center for Oral Disease Regulation of the Aged, School of Dentistry, Chosun University, Gwangju (Korea, Republic of); Choe, Han-Cheol, E-mail: hcchoe@chosun.ac.kr [Department of Dental Materials, Research Center of Nano-Interface Activation for Biomaterials, and Research Center for Oral Disease Regulation of the Aged, School of Dentistry, Chosun University, Gwangju (Korea, Republic of); Brantley, William A. [Division of Restorative, Prosthetic and Primary Care Dentistry, College of Dentistry, The Ohio State University, 305 W. 12th Ave., Columbus, OH (United States)

    2013-11-01

    The purpose of this study was to investigate the electrochemical characteristics of silicon-substituted hydroxyapatite coatings on the nanotube-formed Ti–35Nb–10Zr alloy. The silicon-substituted hydroxyapatite (Si–HA) coatings on the nanotube structure were deposited by electron beam-physical vapor deposition and anodization methods, and biodegradation properties were analyzed by potentiodynamic polarization and electrochemical impedance spectroscopy measurement. The surface characteristics were analyzed by field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy and X-ray diffraction (XRD). The Si–HA layers were deposited with rough features having highly ordered nanotube structures on the titanium alloy substrate. The thickness of the Si–HA coating was less than that of the HA coating. The XRD results confirmed that the Si–HA coating on the nanotube structure consisted of TiO{sub 2} anatase, TiO{sub 2} rutile, hydroxyapatite, and calcium phosphate silicate. The Si–HA coating surface exhibited lower I{sub corr} than the HA coating, and the polarization resistance was increased by substitution of silicon in hydroxyapatite. - Highlights: • Silicon substituted hydroxyapatite (Si–HA) was coated on nanotubular titanium alloy. • The Si–HA coating thickness was less than single hydroxyapatite (HA) coating. • Si–HA coatings consisted of TiO{sub 2}, HA, and Ca{sub 5}(PO{sub 4}){sub 2}SiO{sub 4}. • Polarization resistance of the coating was increased by Si substitution in HA.

  13. The Accessory Factor Nef Links HIV-1 to Tec/Btk Kinases in an Src Homology 3 Domain-dependent Manner*♦

    Science.gov (United States)

    Tarafdar, Sreya; Poe, Jerrod A.; Smithgall, Thomas E.

    2014-01-01

    The HIV-1 Nef virulence factor interacts with multiple host cell-signaling proteins. Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation important for viral infectivity, replication, and MHC-I down-regulation. Itk and other Tec family kinases are also present in HIV target cells, and Itk has been linked to HIV-1 infectivity and replication. However, the molecular mechanism linking Itk to HIV-1 is unknown. In this study, we explored the interaction of Nef with Tec family kinases using a cell-based bimolecular fluorescence complementation assay. In this approach, interaction of Nef with a partner kinase juxtaposes nonfluorescent YFP fragments fused to the C terminus of each protein, resulting in YFP complementation and a bright fluorescent signal. Using bimolecular fluorescence complementation, we observed that Nef interacts with the Tec family members Bmx, Btk, and Itk but not Tec or Txk. Interaction with Nef occurs through the kinase Src homology 3 domains and localizes to the plasma membrane. Allelic variants of Nef from all major HIV-1 subtypes interacted strongly with Itk in this assay, demonstrating the highly conserved nature of this interaction. A selective small molecule inhibitor of Itk kinase activity (BMS-509744) potently blocked wild-type HIV-1 infectivity and replication, but not that of a Nef-defective mutant. Nef induced constitutive Itk activation in transfected cells that was sensitive to inhibitor treatment. Taken together, these results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec family and suggest that Nef provides a mechanistic link between HIV-1 and Itk signaling in the viral life cycle. PMID:24722985

  14. The accessory factor Nef links HIV-1 to Tec/Btk kinases in an Src homology 3 domain-dependent manner.

    Science.gov (United States)

    Tarafdar, Sreya; Poe, Jerrod A; Smithgall, Thomas E

    2014-05-30

    The HIV-1 Nef virulence factor interacts with multiple host cell-signaling proteins. Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation important for viral infectivity, replication, and MHC-I down-regulation. Itk and other Tec family kinases are also present in HIV target cells, and Itk has been linked to HIV-1 infectivity and replication. However, the molecular mechanism linking Itk to HIV-1 is unknown. In this study, we explored the interaction of Nef with Tec family kinases using a cell-based bimolecular fluorescence complementation assay. In this approach, interaction of Nef with a partner kinase juxtaposes nonfluorescent YFP fragments fused to the C terminus of each protein, resulting in YFP complementation and a bright fluorescent signal. Using bimolecular fluorescence complementation, we observed that Nef interacts with the Tec family members Bmx, Btk, and Itk but not Tec or Txk. Interaction with Nef occurs through the kinase Src homology 3 domains and localizes to the plasma membrane. Allelic variants of Nef from all major HIV-1 subtypes interacted strongly with Itk in this assay, demonstrating the highly conserved nature of this interaction. A selective small molecule inhibitor of Itk kinase activity (BMS-509744) potently blocked wild-type HIV-1 infectivity and replication, but not that of a Nef-defective mutant. Nef induced constitutive Itk activation in transfected cells that was sensitive to inhibitor treatment. Taken together, these results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec family and suggest that Nef provides a mechanistic link between HIV-1 and Itk signaling in the viral life cycle. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Star and Dust Formation Activities in AzTEC-3: A Starburst Galaxy at z equals 5.3

    Science.gov (United States)

    Dwek, Eliahu

    2011-01-01

    Analyses of of high-redshift ultraluminous infrared (IR) galaxies traditionally use the observed optical to submillimeter spectral energy distribution (SED) and estimates of the dynamical mass as observational constraints to derive the star formation rate (SFR), the stellar mass, and age of these objects. In this lecture we add this constraint to the analysis of AzTEC-3, a starburst galaxy at z=5.3. We construct different stellar and chemical evolutionary scenarios, constrained to produce the inferred dust mass and observed luminosity before the associated stellar mass exceeds the observational limit. A robust result of our models is that all scenarios require most of the radiating dust mass to have been accreted in molecular clouds. Our new procedure highlights the importance of a multi wavelength approach, and of the use of dust evolution models in constraining the age and the star formation activity and history in galaxies.

  16. Star Dust Formation Activities in AzTEC-3: A Starburst Galaxy at z=5.3

    Science.gov (United States)

    Dwek, Eliahu

    2011-01-01

    Analyses of of high-redshift ultraluminous infrared OR) galaxies traditionally use the observed optical to submillimeter spectral energy distribution (SED) and estimates of the dynamical mass as observational constraints to derive the star formation rate (SFR), the stellar mass, and age of these objects. In this lecture we add this constraint to the analysis of AzTEC-3, a starburst galaxy at z=5.3. We construct different stellar and chemical evolutionary scenarios, constrained to produce the inferred dust mass and observed luminosity before the associated stellar mass exceeds the observational limit. A robust result of our models is that all scenarios require most of the radiating dust mass to have been accreted in molecular clouds. Our new procedure highlights the importance of a multi wavelength approach, and of the use of dust evolution models in constraining the age and the star formation activity and history in galaxies.

  17. Star and Dust Formation Activities in AzTEC-3: A Starburst Galaxy at z=5.3

    Science.gov (United States)

    Dwek, Eliahu

    2011-01-01

    Analyses of of high-redshift ultraluminous infrared (IR) galaxies traditionally use the observed optical to submillimeter spectral energy distribution (SED) and estimates of the dynamical mass as observational constraints to derive the star formation rate (SFR), the stellar mass, and age of these objects. In this lecture we add this constraint to the analysis of AzTEC-3, a starburst galaxy at z=5.3. We construct different stellar and chemical evolutionary scenarios, constrained to produce the inferred dust mass and observed luminosity before the associated stellar mass exceeds the observational limit. A robust result of our models is that all scenarios require most of the radiating dust mass to have been accreted in molecular clouds. Our new procedure highlights the importance of a multiwavelength approach, and of the use of dust evolution models in constraining the age and the star formation activity and history in galaxies.

  18. TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma

    Science.gov (United States)

    Kannan, Yashaswini; Wilson, Mark S.

    2013-01-01

    Significant advances in our understanding of the signalling events during T cell development and differentiation have been made in the past few decades. It is clear that ligation of the T cell receptor (TCR) triggers a series of proximal signalling cascades regulated by an array of protein kinases. These orchestrated and highly regulated series of events, with differential requirements of particular kinases, highlight the disparities between αβ+CD4+ T cells. Throughout this review we summarise both new and old studies, highlighting the role of Tec and MAPK in T cell development and differentiation with particular focus on T helper 2 (TH2) cells. Finally, as the allergy epidemic continues, we feature the role played by TH2 cells in the development of allergy and provide a brief update on promising kinase inhibitors that have been tested in vitro, in pre-clinical disease models in vivo and into clinical studies. PMID:24116341

  19. GPS TEC Fluctuations in the Low and High Latitudes During the 2015 St. Patrick`s Day Storm

    Science.gov (United States)

    Chung, Jong-Kyun; Hong, Junseok; Yoo, Sung-Moon; Kim, Jeong-Han; Jee, Geonhwa; Hegai, Valery V.

    2017-12-01

    As a part of collaborative efforts to understand ionospheric irregularities, the Korea ionospheric scintillation sites (KISS) network has been built based on global positioning system (GPS) receivers with sampling rates higher than 1 Hz. We produce the rate of TEC index (ROTI) to represent GPS TEC fluctuations related to ionospheric irregularities. In the KISS network, two ground-based GPS sites at Kiruna (marker: KIRN; geographic: 67.9° N, 21.4° E; geomagnetic: 65.2° N) and Chuuk (marker: CHUK; geographic: 7.5° N, 151.9° E; geomagnetic: 0.4° N) were selected to evaluate the ROTI value for ionospheric irregularities during the occurrence of the 2015 St. Patrick’s Day storm. The KIRN ROTI values in the aurora region appear to be generally much higher than the CHUK ROTI values in the EIA region. The CHUK ROTI values increased to 0.5 TECU/min around UT=13:00 (LT=23:00) on March 16 in the quiet geomagnetic condition. On March 17, 2015, CHUK ROTI values more than 1.0 TECU/min were measured between UT=9:00 and 12:00 (LT=19:00 and 22:00) during the first main phase of the St. Patrick’s Day storm. This may be due to ionospheric irregularities by increased pre-reversal enhancement (PRE) after sunset during the geomagnetic storm. Post-midnight, the CHUK ROTI showed two peaks of 0.5 TECU/min and 0.3 TECU/min near UT=15:00 (LT=01:00) and UT=18:00 (LT=04:00) at the second main phase. The KIRN site showed significant peaks of ROTI around geomagnetic latitude=63.3° N and MLT=15:40 on the same day. These can be explained by enhanced ionospheric irregularities in the auroral oval at the maximum of AE index

  20. Outcomes of dialysis catheters placed by the Y-TEC peritoneoscopic technique: a single-center surgical experience.

    Science.gov (United States)

    Al Azzi, Yorg; Zeldis, Etti; Nadkarni, Girish N; Schanzer, Harry; Uribarri, Jaime

    2016-02-01

    In the last few years, peritoneal dialysis (PD) catheter placement techniques and outcomes have become important because of the growing population of PD patients. Although there are a growing number of catheters placed by the minimally invasive Y-TEC peritoneoscopic technique, there are still limited data on outcomes for these catheters, especially those placed by a surgeon. We aimed to conduct a retrospective study of our experience with PD catheters placed by the Y-TEC peritoneoscopic technique in our institution. We reviewed patients with peritoneoscopic PD catheter insertion over the last decade and described their complications and outcomes. In a secondary analysis, we compared the outcomes and complications of these catheters with those with open placement placed by the same surgeon. We had complete data on 62 patients with peritoneoscopic catheter placement during the study period. The mean age was 55 years, 48.4% were females and the most common cause of end-stage renal disease was diabetes mellitus (33%). Surgical complications were seen in only 6/62 (9.6%) and peritonitis in 16/62 (26%) of peritoneoscopic catheters. Most catheters were used after 2 months of placement, while 12.3% were used within 2 months. When compared with 93 patients with open placement of catheters as a secondary analysis, peritoneoscopic catheters were found to have a higher 2-year survival. Our large series of peritoneoscopically placed catheters by a surgeon demonstrate low surgical complications and peritonitis rates as well as superior 2-year survival compared with open placement of catheters.

  1. Estimation of changes in nickel and chromium content in nickel-titanium and stainless steel orthodontic wires used during orthodontic treatment: An analytical and scanning electron microscopic study

    Directory of Open Access Journals (Sweden)

    Vandana Kararia

    2015-01-01

    Full Text Available Introduction: The biocompatibility of orthodontic dental alloys has been investigated over the past 20 years, but the results have been inconclusive. The study compares standard 3 M Unitek nickel-titanium (NiTi and stainless steel archwires with locally available JJ orthodontics wires. Scanning electron microscope (SEM study of surface changes and complexometric titration to study compositional change was performed. Materials and Methods: Ten archwires each of group 1-3 M 0.016" NiTi, group 2-JJ 0.016" NiTi, group 3-3 M 0.019" FNx010.025" SS and group 4-JJ SS contributed a 10 mm piece of wire for analysis prior to insertion in the patient and 6 weeks post insertion. SEM images were recorded at Χ2000, Χ4000 and Χ6000 magnification. The same samples were subjected to complexiometric titration using ethylenediaminetetraacetic acid to gauge the actual change in the composition. Observations and Results: The SEM images of all the archwires showed marked changes with deep scratches and grooves and dark pitting corrosion areas post intraoral use. 3M wires showed an uniform criss-cross pattern in as received wires indicating a coating which was absent after intraoral use. There was a significant release of Nickel and Chromium from both group 3 and 4. Group 2 wires released ions significantly more than group 1 (P = 0.0. Conclusion: Extensive and stringent trials are required before certifying any product to be used in Orthodontics.

  2. Estimation of changes in nickel and chromium content in nickel-titanium and stainless steel orthodontic wires used during orthodontic treatment: An analytical and scanning electron microscopic study.

    Science.gov (United States)

    Kararia, Vandana; Jain, Pradeep; Chaudhary, Seema; Kararia, Nitin

    2015-01-01

    The biocompatibility of orthodontic dental alloys has been investigated over the past 20 years, but the results have been inconclusive. The study compares standard 3 M Unitek nickel-titanium (NiTi) and stainless steel archwires with locally available JJ orthodontics wires. Scanning electron microscope (SEM) study of surface changes and complexometric titration to study compositional change was performed. Ten archwires each of group 1-3 M 0.016" NiTi, group 2-JJ 0.016" NiTi, group 3-3 M 0.019" *0.025" SS and group 4-JJ SS contributed a 10 mm piece of wire for analysis prior to insertion in the patient and 6 weeks post insertion. SEM images were recorded at ×2000, ×4000 and ×6000 magnification. The same samples were subjected to complexiometric titration using ethylenediaminetetraacetic acid to gauge the actual change in the composition. The SEM images of all the archwires showed marked changes with deep scratches and grooves and dark pitting corrosion areas post intraoral use. 3M wires showed an uniform criss-cross pattern in as received wires indicating a coating which was absent after intraoral use. There was a significant release of Nickel and Chromium from both group 3 and 4. Group 2 wires released ions significantly more than group 1 (P = 0.0). Extensive and stringent trials are required before certifying any product to be used in Orthodontics.

  3. Manipulating the Energetics and Rates of Electron Transfer in Rhodobacter capsulatus Reaction Centers with Asymmetric Pigment Content

    Energy Technology Data Exchange (ETDEWEB)

    Faries, Kaitlyn M. [Department; Dylla, Nicholas P. [Biosciences Division, Argonne National Laboratory, Lemont, Illinois 60439, United States; Hanson, Deborah K. [Biosciences Division, Argonne National Laboratory, Lemont, Illinois 60439, United States; Holten, Dewey [Department; Laible, Philip D. [Biosciences Division, Argonne National Laboratory, Lemont, Illinois 60439, United States; Kirmaier, Christine [Department

    2017-07-17

    Seemingly redundant parallel pathways for electron transfer (ET), composed of identical sets of cofactors, are a cornerstone feature of photosynthetic reaction centers (RCs) involved in light-energy conversion. In native bacterial RCs, both A and B branches house one bacteriochlorophyll (BChl) and one bacteriopheophytin (BPh), but the A branch is used exclusively. Described herein are the results-obtained for two Rhodobacter capsulatus RCs with an unnaturally high degree of cofactor asymmetry, two BPh on the RC's B side and two BChl on the A side. These pigment changes derive, respectively, from the His(M180)Leu mutation [a BPh ((Phi(B)) replaces the B-side BChl (BB)], and the Leu(M212)His mutation [a BChl (beta(A))) replaces the A-side BPh (H-A)]. Additionally, Tyr(M208)Phe was employed to disfavor ET to the A branch; in one mutant, Val(M131)Glu creates a hydrogen bond to H-B to enhance ET to H-B. In both Phi(B) mutants, the decay kinetics of the excited primary ET donor (P*) resolve three populations with lifetimes of similar to 9 ps (50-60%), similar to 40 ps (10-20%), and similar to 200 ps (20-30%), with P+Phi(-)(B) formed predominantly from the 9 ps fraction. The 50-60% yield of P+Phi(B)- is the highest yet observed for a Phi(B)-containing RC. The results provide insight into factors needed for efficient multistep ET.

  4. Effect of increasing tellurium content on the electronic and optical properties of cadmium selenide telluride alloys CdSe{sub 1-x}Te{sub x}: An ab initio study

    Energy Technology Data Exchange (ETDEWEB)

    Reshak, Ali Hussain, E-mail: maalidph@yahoo.co.uk [Institute of Physical Biology-South Bohemia University, Nove Hrady 37333 (Czech Republic); School of Material Engineering, Malaysia University of Perlis, P.O Box 77, d/a Pejabat Pos Besar, 01007 Kangar, Perlis (Malaysia); Kityk, I.V. [Electrical Engineering Department, Technical University of Czestochowa, Al. Armii Krajowej 17/19, Czestochowa (Poland); Khenata, R. [Laboratoire de Physique Quantique et de Modelisation Mathematique de la Matiere (LPQ3 M), universite de Mascara, Mascara 29000 (Algeria); Department of Physics and Astronomy, King Saud University, P.O. Box 2455, Riyadh 11451 (Saudi Arabia); Auluck, S. [National Physical Laboratory Dr. K S Krishnan Marg, New Delhi 110012 (India)

    2011-06-16

    Highlights: > Theoretical study of effect of vary Te content on band structure, density of states, linear and nonlinear optical susceptibilities of CdSe{sub 1-x}Te{sub x}. > Increasing Te content leads to a decrease in the energy band gap. > Significant enhancement of the electronic properties as a function of tellurium concentration - Abstract: An all electron full potential linearized augmented plane wave method, within a framework of GGA (EV-GGA) approach, has been used for an ab initio theoretical study of the effect of increasing tellurium content on the band structure, density of states, and the spectral features of the linear and nonlinear optical susceptibilities of the cadmium-selenide-telluride ternary alloys CdSe{sub 1-x}Te{sub x} (x = 0.0, 0.25, 0.5, 0.75 and 1.0). Our calculations show that increasing Te content leads to a decrease in the energy band gap. We find that the band gaps are 0.95 (1.76), 0.89 (1.65), 0.83 (1.56), 0.79 (1.44) and 0.76 (1.31) eV for x = 0.0, 0.25, 0.5, 0.75 and 1.0 in the cubic structure. As these alloys are known to have a wurtzite structure for x less than 0.25, the energy gaps are 0.8 (1.6) eV and 0.7 (1.55) eV for the wurtzite structure (x = 0.0, 0.25) for the GGA (EV-GGA) exchange correlation potentials. This reduction in the energy gaps enhances the functionality of the CdSe{sub 1-x}Te{sub x} alloys, at least for these concentrations, leading to an increase in the effective second-order susceptibility coefficients from 16.75 pm/V (CdSe) to 18.85 pm/V (CdSe{sub 0.75}Te{sub 0.25}), 27.23 pm/V (CdSe{sub 0.5}Te{sub 0.5}), 32.25 pm/V (CdSe{sub 0.25}Te{sub 0.75}), and 37.70 pm/V (CdTe) for the cubic structure and from 12.65 pm/V (CdSe) to 21.11 pm/V (CdSe{sub 0.75}Te{sub 0.25}) in the wurtzite structure. We find a nonlinear relationship between the absorption/emission energies and composition, and a significant enhancement of the electronic properties as a function of tellurium concentration. This variation will help in

  5. Content Marketing

    OpenAIRE

    Le, Duc

    2013-01-01

    The purpose of this thesis was to introduce the new trend in today’s marketing world: content marketing. It has been employed by many companies and organizations in the world and has been proven success even when it is still a fairly new topic. Five carefully selected theories of content marketing proposed by experts in the field has been collected, compared and displayed as originally and scientifically as possible in this thesis. The chosen theories provide a diversified perspectives of...

  6. Hydrogen-bonding interactions between water and the one- and two-electron-reduced forms of vitamin K1: applying quinone electrochemistry to determine the moisture content of non-aqueous solvents.

    Science.gov (United States)

    Hui, Yanlan; Chng, Elaine Lay Khim; Chng, Cheryl Yi Lin; Poh, Hwee Ling; Webster, Richard D

    2009-02-04

    Vitamin K(1) (VK(1)) was shown by voltammetry and coulometry to undergo two chemically reversible one-electron reduction processes in acetonitrile (CH(3)CN) containing 0.2 M Bu(4)NPF(6) as the supporting electrolyte. The potential separation between the first and second electron-transfer steps diminished sequentially with the addition of water, so that at a H(2)O concentration of approximately 7 M (approximately 13% v/v) only one process was detected, corresponding to the reversible transfer of two electrons per molecule. The voltammetric behavior was interpreted on the basis of the degree of hydrogen bonding between the reduced forms of VK(1) with water in the solvent. It was found that the potential separation between the first and second processes was especially sensitive to water in the low molar levels (0.001-0.1 M); therefore, by measuring the peak separation as a function of controlled water concentrations (accurately determined by Karl Fischer coulometric titrations) it was possible to prepare calibration curves of peak separation versus water concentration. The calibration procedure is independent of the type of reference electrode and can be used to determine the water content of CH(3)CN between 0.01 and 5 M, by performing a single voltammetric scan in the presence of 1.0 mM VK(1). The voltammetry was also investigated in dichloromethane, dimethylformamide, and dimethyl sulfoxide. The reduction processes were monitored by in situ electrochemical UV-vis spectroscopy in CH(3)CN over a range of water concentrations (0.05-10 M) to spectroscopically identify the hydrogen-bonded species.

  7. Growth of L-band scintillation at anomaly crest station in association with strong TEC gradient: A study covering wide solar activity period

    Science.gov (United States)

    Pathak, K.; Devi, M.; Barbara, A. K.; Zahan, Y.

    2018-01-01

    The paper aims at to study the sources associated with growth of L band scintillation over Guwahati, an Appleton anomaly region. Starting with the analysis of diurnal and seasonal characteristic features of scintillation from a minimum sunspot number (Rz) of 10 to a maximum of 140, the paper shows that scintillations are more likely to develop during high solar activity period. It also highlights the explosive increase in occurrence of scintillation from post sunset to pre midnight hours in vernal equinoctial months when the background TEC is 50% more than on a normal day, accompanied by enhanced TEC decay rate. The role of equatorial anomaly effects through EXB drift processes are brought into discussion as possible sources on the growth of small scale irregularities leading to such scintillations.

  8. First-line treatment of advanced ovarian cancer with paclitaxel/carboplatin with or without epirubicin (TEC versus TC)--a gynecologic cancer intergroup study of the NSGO, EORTC GCG and NCIC CTG.

    Science.gov (United States)

    Lindemann, K; Christensen, R D; Vergote, I; Stuart, G; Izquierdo, M A; Kærn, J; Havsteen, H; Eisenhauer, E; Ridderheim, M; Lopez, A B; Hirte, H; Aavall-Lundquvist, E; Vrdoljak, E; Green, J; Kristensen, G B

    2012-10-01

    The addition of anthracyclines to platinum-based chemotherapy may provide benefit in survival in ovarian cancer patients. We evaluated the effect on survival of adding epirubicin to standard carboplatin and paclitaxel. We carried out a prospectively randomized phase III study comparing carboplatin plus paclitaxel (TC; area under the curve 5 and 175 mg/m(2)) with the same combination and epirubicin (TEC; 75 mg/m(2) i.v.). Between March 1999 and August 2001, 887 patients with epithelial ovarian, tubal or peritoneal cancer International Federation of Gynecology and Obstetrics stages IIB-IV were randomized to receive either TC (442 patients) or TEC (445 patients). Median time to progression was 16.4 months in the TEC arm and 16.0 months in the TC arm (hazard ratio 0.99; 95% confidence interval [CI]: 0.9-1.2). Median overall survival time was 42.4 months for the TEC arm and 40.2 for the TC arm (hazard ratio 0.96; 95% CI: 0.8-1.1). Grade 3/4 hematologic toxic effects and most grade 3/4 non-hematologic toxic effects were more frequent in the TEC arm. Accordingly, a quality-of-life analysis showed inferiority of TEC versus TC. The addition of epirubicin to standard carboplatin and paclitaxel treatment did not improve survival in patients with advanced ovarian, tubal or peritoneal cancer.

  9. Local Content

    CSIR Research Space (South Africa)

    Gibberd, Jeremy

    2016-10-01

    Full Text Available , 1997; Qiu & Tao, 2001; Corkin, 2012; Warner, 2011; Stephenson, 2013). Local content is also seen a way of improving national sustainability performance and developing greener buildings (Olivier et al, 2016; van Reneen, 2014; Gibberd, 2002). As a result...

  10. Effectiveness of EarthTec(®) for killing invasive quagga mussels (Dreissena rostriformis bugensis) and preventing their colonization in the Western United States.

    Science.gov (United States)

    Watters, Ashlie; Gerstenberger, Shawn L; Wong, Wai Hing

    2013-01-01

    Quagga mussels (Dreissena rostriformis bugensis) have created economic and ecological impacts in the western United States since their discovery in 2007. This study focuses on chemical control for preventing the spread of these mussels. The effectiveness of EarthTec(®) in killing quagga mussels (adults, juveniles, and veligers) in Lake Mead, Nevada-Arizona, was evaluated over time across six concentrations: 0, 1, 5, 10, 17, and 83 ppm. One hundred percent mortality of adult and juvenile mussels was achieved after 96 h with 17 ppm and 5 ppm (respectively), and 100% veliger mortality occurred within 30 min at 3 ppm. From December 2010 to February 2011, the effectiveness of EarthTec(®) in preventing veliger colonization was also evaluated and the results showed that 2.8 ppm was effective in preventing veliger colonization on fiberglass panels. This study indicates that EarthTec(®) has the potential to be an effective control agent against the invasive quagga mussel, and more specifically, in preventing the colonization of veligers.

  11. TecLines: A MATLAB-Based Toolbox for Tectonic Lineament Analysis from Satellite Images and DEMs, Part 1: Line Segment Detection and Extraction

    Directory of Open Access Journals (Sweden)

    Mehdi Rahnama

    2014-06-01

    Full Text Available Geological structures, such as faults and fractures, appear as image discontinuities or lineaments in remote sensing data. Geologic lineament mapping is a very important issue in geo-engineering, especially for construction site selection, seismic, and risk assessment, mineral exploration and hydrogeological research. Classical methods of lineaments extraction are based on semi-automated (or visual interpretation of optical data and digital elevation models. We developed a freely available Matlab based toolbox TecLines (Tectonic Lineament Analysis for locating and quantifying lineament patterns using satellite data and digital elevation models. TecLines consists of a set of functions including frequency filtering, spatial filtering, tensor voting, Hough transformation, and polynomial fitting. Due to differences in the mathematical background of the edge detection and edge linking procedure as well as the breadth of the methods, we introduce the approach in two-parts. In this first study, we present the steps that lead to edge detection. We introduce the data pre-processing using selected filters in spatial and frequency domains. We then describe the application of the tensor-voting framework to improve position and length accuracies of the detected lineaments. We demonstrate the robustness of the approach in a complex area in the northeast of Afghanistan using a panchromatic QUICKBIRD-2 image with 1-meter resolution. Finally, we compare the results of TecLines with manual lineament extraction, and other lineament extraction algorithms, as well as a published fault map of the study area.

  12. The StenTec gauge for measuring static intra-access pressure ratio (P(Ia Ratio) ) of fistulas and grafts.

    Science.gov (United States)

    Ash, Stephen R; Dhamija, Rajiv; Zaroura, Mohamad Y; Hentschel, Dirk M

    2012-07-01

    The StenTec™ Gauge provides a method to determine the static intra-access pressure ratio (P(Ia Ratio) ) within a fistula or graft. The StenTec Gauge estimates the peak systolic pressure within the fistula or graft by measurement of the distance that the blood-air interface progresses into the tubing of the fistula needle, after the needle is inserted "dry" into the fistula or graft and before the cap is removed from the tubing. The peak systolic pressure is graphically compared with the systolic arterial blood pressure of the patient, to determine P(Ia Ratio) . For best accuracy, the StenTec Gauge should be chosen that best matches the internal volume of the fistula needle tubing (2.3-2.6 ml for 12-inch tubing and 3.6 ml for 16-inch tubing) and the approximate elevation of the city in which it is used (0-1000, 1000-3000, and 3000-6000 feet above sea level). In this article, we explain the rationale for this method of surveillance, evidence for accuracy of the StenTec Gauge, and the correlation of changes in the P(Ia Ratio) to the development of stenosis in a fistula or graft. © 2012 Wiley Periodicals, Inc.

  13. Evaluation of the Cica Fungi Test Candida, a novel serum Candida mannan antigen kit, and its comparison with Cand-Tec in candidemia patients.

    Science.gov (United States)

    Takazono, Takahiro; Izumikawa, Koichi; Nagayoshi, Yosuke; Tanaka, Akitaka; Mihara, Tomo; Kosai, Kosuke; Saijo, Tomomi; Imamura, Yoshifumi; Miyazaki, Taiga; Seki, Masafumi; Kakeya, Hiroshi; Yamamoto, Yoshihiro; Yanagihara, Katsunori; Kamihira, Shimeru; Kohno, Shigeru

    2011-01-01

    The Cica Fungi Test Candida is a novel immunoassay test that is used in Japan to detect Candida mannan antigens. A total of 130 samples from 89 cases in which the β-D-glucan assay (MK method) was positive were collected between July 2007 and August 2008 at Nagasaki University Hospital, and the Cica Fungi Test Candida and Cand-Tec were performed. Diagnosis of candidemia was based on a positive culture for Candida spp. from blood or other sterile clinical specimens. A total of 19 samples from 16 cases with candidemia, and 111 samples from 73 cases without microbiological evidence of candidemia, were obtained. The sensitivity and specificity of the Cica Fungi Test and Cand-Tec were 63.2 and 95.5%, and 52.6 and 50.5%, respectively. The Cica Fungi Test showed significantly higher specificity than Cand-Tec (PTec, and the combined evaluation with the β-D-glucan assay was more efficient for diagnosis of candidemia.

  14. Electronics and electronic systems

    CERN Document Server

    Olsen, George H

    1987-01-01

    Electronics and Electronic Systems explores the significant developments in the field of electronics and electronic devices. This book is organized into three parts encompassing 11 chapters that discuss the fundamental circuit theory and the principles of analog and digital electronics. This book deals first with the passive components of electronic systems, such as resistors, capacitors, and inductors. These topics are followed by a discussion on the analysis of electronic circuits, which involves three ways, namely, the actual circuit, graphical techniques, and rule of thumb. The remaining p

  15. Electronics for dummies

    CERN Document Server

    Shamieh

    2015-01-01

    Explore the basic concepts of electronics, build your electronics workbench, and begin creating fun electronics projects right away! Electronics For Dummies, 3rd Edition is your guide to the world of electronics. Spanning circuitry, wiring, robotics, transmitters, amplifiers, and more, this book demystifies electricity basics and beyond. The third edition offers new content revised to reflect the latest advancements in the electronics field, and it offers full color project examples to spark your creativity and inspire you to put your new skills to use! Packed with projects that can be comple

  16. Content Analysis

    Directory of Open Access Journals (Sweden)

    George Bedinelli Rossi

    2014-09-01

    Full Text Available This study introduces the various definitions and types of content analysis. This type of analysis historically presents itself as a quantitative approach to data analysis and currently shows up as a qualitative approach. The most common types are the conceptual and relational analysis. The latter receives influences of linguistic, cognitive and mental models and it is subdivided in affective extraction, analysis of proximity and cognitive mapping. Regarding the importance of this type of analysis, we have quantitative and qualitative character and the latter approach can be used to identify hypotheses, theoretical constructs or even models that can be tested by multivariate statistical techniques or even by experiments. 

  17. Electron density and plasma waves in mid-latitude sporadic-E layer observed during the SEEK-2 campaign

    Directory of Open Access Journals (Sweden)

    H. Mori

    2005-10-01

    Full Text Available The SEEK-2 campaign was carried out over Kyushu Island in Japan on 3 August 2002, by using the two sounding rockets of S310-31 and S310-32. This campaign was planned to elucidate generation mechanisms of Quasi-Periodic Echoes (QPEs associated with mid-latitude sporadic-E (Es layers. Electron number densities were successfully measured in the Es layers by using the impedance probe on board two rockets. The plasma waves in the VLF and ELF ranges were also observed on board the S310-32 rocket. Results of electron density measurement showed that there were one or two major peaks in the Es layers along the rockets' trajectories near the altitude of about 10km. There were some smaller peaks associated with the main Es layers in the altitude range from 90 to 120 km. These density peaks were distributed in a very large extent during the SEEK-2 campaign. The Es layer structure is also measured by using the Fixed Bias Probe (FBP, which has a high spatial resolution of several meters (the impedance probe has an altitude resolution of about 400 m. The comparison with the total electron content (TEC measured by the Dual Band Beacon revealed that the Es layer was also modulated in the horizontal direction with the scale size of 30–40 km. It was shown that the QP echoes observed by the ground-based coherent radar come from the major density peak of the Es layer. The plasma wave instrument detected the enhancement of VLF and ELF plasma waves associated with the operation of the TMA release, and also with the passage of the Es layers. Keywords. Ionosphere (Ionospheric irregularities; Midlatitude ionosphere; Plasma temeperature and density

  18. Innovative direct energy conversion systems from fusion output thermal power to the electrical one with the use of electronic adiabatic processes of electron fluid in solid conductors

    International Nuclear Information System (INIS)

    Kondoh, Y.; Kondo, M.; Shimoda, K.; Takahashi, T.; Osuga, K.

    2003-07-01

    It is shown that with the use of the fusion output and/or environmental thermal energy, innovative open systems for permanent auto-working (PA) direct energy converting (DEC) from the thermal to the electrical (TE) and further to the chemical potential (TEC) energies, abbreviated as PA-TEC-DEC systems, can be used for new auto-working electrical power plants and the plants of the compressible and conveyable hydrogen gas resources at various regions in the whole world. It is analytically shown that the same physical mechanism by free electrons and electrical potential determined by temperature in conductors, which include semiconductors, leads to the Peltier effect and the Seebeck one. It is analytically proved that the energy conservation law is exactly satisfied in a simple form where the net absorbed thermal power is directly transferred to the electrical power and to the chemical power in the PA-TEC-DEC systems. It is analytically and experimentally clarified that the long distance separation between two π type elements of the heat absorption side and the production one of the Peltier effect circuit system or between the higher temperature side and the lower one of the Seebeck effect circuit one does not change mechanisms of the heat pumping by the Peltier effect and of the TE-DEC by the Seebeck effect. The proposed systems gives us freedom of no using the fossil fuel, such as coals, oils, and natural gases that yield serious greenhouse effect all over the earth, and the plant of nuclear fissions that left radiating wastes, i.e., no more environmental pollutions. The PA-TEC-DEC systems can be applicable for several km scale systems to the micro ones, such as the plants of the electrical power and the hydrogen gas resources, compact transportable hydrogen gas producers, the refrigerators, the air conditions, home electrical apparatuses, and further the computer elements. (author)

  19. Comparison of (1→3)-β-d-Glucan, Mannan/Anti-Mannan Antibodies, and Cand-Tec Candida Antigen as Serum Biomarkers for Candidemia

    Science.gov (United States)

    Kohlberger, Isabelle; Rappold, Elfriede; Busse Grawitz, Andrea; Häcker, Georg

    2013-01-01

    We conducted a case-control study using the Fungitell assay, the novel Platelia Candida Antigen (Ag) Plus and Candida Antibody (Ab) Plus assays, and the Cand-Tec latex agglutination test to evaluate the usefulness of (1→3)-β-d-glucan (BDG), mannan antigen with/without anti-mannan antibody, and Cand-Tec Candida antigen measurement for the diagnosis of candidemia. A total of 56 patients fulfilled the inclusion criteria and were enrolled. One hundred patients with bacteremia and 100 patients with sterile blood cultures served as negative controls. In the candidemia group, median (1→3)-β-d-glucan, mannan antigen, and anti-mannan antibody levels were 427 pg/ml, 190 pg/ml, and 18.6 antibody units (AU)/ml, respectively. All three parameters were significantly elevated in patients with candidemia. The sensitivity and specificity were, respectively, 87.5% and 85.5% for (1→3)-β-d-glucan, 58.9% and 97.5% for mannan antigen, 62.5% and 65.0% for anti-mannan antibody, 89.3% and 63.0% for mannan antigen plus anti-mannan antibody, 89.3% and 85.0% for BDG plus mannan antigen, and 13.0% and 93.9% for Cand-Tec Candida antigen. The low mannan antigen sensitivity was in part caused by Candida parapsilosis and Candida guilliermondii fungemias, which were not detected by the Platelia Candida Ag Plus assay. When the cutoff was lowered from 125 pg/ml to 50 pg/ml, mannan antigen sensitivity increased to 69.6% without severely affecting the specificity (93.5%). Contrary to recently published data, superficial candidiasis was not associated with elevated mannan antigen levels, not even after the cutoff was lowered. Combining procalcitonin (PCT) with (1→3)-β-d-glucan to increase specificity provided a limited advantage because the benefit of the combination did not outweigh the loss of sensitivity. Our results demonstrate that the Cand-Tec Candida antigen and the mannan antigen plus anti-mannan antibody measurements have unacceptably low sensitivity or specificity. Of the four

  20. Antibody responses induced by Leish-Tec®, an A2-based vaccine for visceral leishmaniasis, in a heterogeneous canine population.

    Science.gov (United States)

    Testasicca, Miriam C de Souza; dos Santos, Mariana Silva; Machado, Leopoldo Marques; Serufo, Angela Vieira; Doro, Daniel; Avelar, Daniel; Tibúrcio, Ana Maria Leonardi; Abrantes, Christiane de Freitas; Machado-Coelho, George Luiz Lins; Grimaldi, Gabriel; Gazzinelli, Ricardo Tostes; Fernandes, Ana Paula

    2014-08-29

    Zoonotic visceral leishmaniasis (VL) is a widespread disease, and dogs are the main reservoirs for human parasite transmission. Hence, development of an effective vaccine that prevents disease and reduces the transmission of VL is required. As euthanasia of seropositive dogs is recommended in Brazil for VL epidemiological control, to include anti-VL canine vaccines as a mass control measure it is necessary to characterize the humoral responses induced by vaccination and if they interfere with the reactivity of vaccinated dogs in serological diagnostic tests. Leish-Tec(®) is an amastigote-specific A2 recombinant protein vaccine against canine visceral leishmaniasis (CVL) that is commercially available in Brazil. Here, we tested the immunogenicity of Leish-Tec(®) in a heterogeneous dog population by measuring A2-specific antibody responses. Healthy dogs (n=140) of various breeds were allocated to two groups: one group received Leish-Tec(®) (n=70), and the other group received a placebo (n=70). Anti-A2 or anti-Leishmania promastigote antigen (LPA) antibody levels were measured by ELISA in serum samples collected before and after vaccination. An immunochromatographic test (DPP) based on the recombinant K28 antigen was also used for serodiagnosis of CVL. Vaccinated animals, except one, remained seronegative for anti-LPA total IgG and anti-K28 antibodies. Conversely, seropositivity for anti-A2 total IgG antibodies was found in 98% of animals after vaccination. This value decreased to 81.13% at 6 months before rising again (98%), after the vaccination boost. Anti-A2 IgG2 and IgG1 titers were also increased in vaccinated animals relative to control animals. These data indicate that Leish-Tec(®) is immunogenic for dogs of different genetic backgrounds and that humoral responses induced by vaccination can be detected by A2-ELISA, but do not interfere with the LPA-ELISA and DPP diagnostic tests for CVL. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Comparison of (1->3)-β-D-glucan, mannan/anti-mannan antibodies, and Cand-Tec Candida antigen as serum biomarkers for candidemia.

    Science.gov (United States)

    Held, Jürgen; Kohlberger, Isabelle; Rappold, Elfriede; Busse Grawitz, Andrea; Häcker, Georg

    2013-04-01

    We conducted a case-control study using the Fungitell assay, the novel Platelia Candida Antigen (Ag) Plus and Candida Antibody (Ab) Plus assays, and the Cand-Tec latex agglutination test to evaluate the usefulness of (1→3)-β-D-glucan (BDG), mannan antigen with/without anti-mannan antibody, and Cand-Tec Candida antigen measurement for the diagnosis of candidemia. A total of 56 patients fulfilled the inclusion criteria and were enrolled. One hundred patients with bacteremia and 100 patients with sterile blood cultures served as negative controls. In the candidemia group, median (1→3)-β-D-glucan, mannan antigen, and anti-mannan antibody levels were 427 pg/ml, 190 pg/ml, and 18.6 antibody units (AU)/ml, respectively. All three parameters were significantly elevated in patients with candidemia. The sensitivity and specificity were, respectively, 87.5% and 85.5% for (1→3)-β-D-glucan, 58.9% and 97.5% for mannan antigen, 62.5% and 65.0% for anti-mannan antibody, 89.3% and 63.0% for mannan antigen plus anti-mannan antibody, 89.3% and 85.0% for BDG plus mannan antigen, and 13.0% and 93.9% for Cand-Tec Candida antigen. The low mannan antigen sensitivity was in part caused by Candida parapsilosis and Candida guilliermondii fungemias, which were not detected by the Platelia Candida Ag Plus assay. When the cutoff was lowered from 125 pg/ml to 50 pg/ml, mannan antigen sensitivity increased to 69.6% without severely affecting the specificity (93.5%). Contrary to recently published data, superficial candidiasis was not associated with elevated mannan antigen levels, not even after the cutoff was lowered. Combining procalcitonin (PCT) with (1→3)-β-D-glucan to increase specificity provided a limited advantage because the benefit of the combination did not outweigh the loss of sensitivity. Our results demonstrate that the Cand-Tec Candida antigen and the mannan antigen plus anti-mannan antibody measurements have unacceptably low sensitivity or specificity. Of the four

  2. Web content a writer's guide

    CERN Document Server

    Mizrahi, Janet

    2013-01-01

    The explosion of electronic sources, whether in the form of news, commentary, sales and marketing, or information, has created boundless opportunities for producing content. Whether you're an entrepreneur with a start-up business who needs a website, an executive who uses social media to connect with various stakeholders, or a content provider blogging about topical issues, you'll need to know how to write for the web and address the unique environment of the digital world. This book will help you produce web content that generates results. Writing for the screen differs from writing for a pri

  3. Basic Electronics I.

    Science.gov (United States)

    Robertson, L. Paul

    Designed for use in basic electronics programs, this curriculum guide is comprised of twenty-nine units of instruction in five major content areas: Orientation, Basic Principles of Electricity/Electronics, Fundamentals of Direct Current, Fundamentals of Alternating Current, and Applying for a Job. Each instructional unit includes some or all of…

  4. Safeguarding Digital Library Contents: Charging for Online Content.

    Science.gov (United States)

    Herzberg, Amir

    1998-01-01

    Investigates the need for mechanisms for charging by digital libraries and other providers of online content, in particular for micropayments, i.e., charging for small amounts. The SSL (Secure Socket Layer) and SET (Secure Electronic Transactions) protocols for charge card payments and the MiniPay micropayment mechanism for charging small amounts…

  5. Revisión anatomofuncional de la neurología visual. Reporte de caso: discapacidad visual neurológica pos-TEC con hematomas subdurales subcrónicos bilaterales parietooccipitales

    Directory of Open Access Journals (Sweden)

    Esteban O. Vallejo Agudelo

    2016-01-01

    Full Text Available El TEC según la IBIA es la principal causa de convulsiones, muerte y discapacidad adquirida mundialmente. Las principales causas son las caídas en mayores de 65 años y los accidentes de tránsito en los menores. Los hematomas pos-TEC son una complicación muy frecuente, cuyas manifestaciones son variables, especialmente en los subdurales, presentando desde cefalea hasta síndromes demenciales o déficit neurológico focal, dentro de los cuales no es usual el reporte de casos con manifestaciones visuales. El presente artículo reporta un caso de discapacidad visual por déficit neurológico pos-TEC complicado con hematomas subdurales subcrónicos bilaterales parietooccipitales, y revisa la neuroanatomía funcional visual involucrada en ella.

  6. 5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils.

    Science.gov (United States)

    Liao, Hsiang-Ruei; Chen, Jih-Jung; Chien, Yin-Huan; Lin, Shinn-Zhi; Lin, Shunchih; Tseng, Ching-Ping

    2012-07-15

    Respiratory burst mediates crucial bactericidal mechanism in neutrophils. However, undesirable respiratory burst leads to pathological inflammation and tissue damage. This study investigates the effect and the underlying mechanism of 5-hydroxy-7-methoxyflavone (MCL-1), a lignan extracted from the leaves of Muntingia calabura L. (Tiliaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst and cathepsin G release in human neutrophils. Signaling pathways regulated by MCL-1 to oppose fMLP-induced respiratory burst were evaluated by membrane localization of Tec induced by fMLP and by immunoblotting analysis of downstream phosphorylation targets of Tec. Briefly, MCL-1 specific inhibited fMLP-induced superoxide anion production in a concentration-dependent (IC(50)=0.16±0.01 μM) and Tec kinase-dependent manner, however, MCL-1 did not affect fMLP-induced cathepsin G release. Further, MCL-1 suppressed fMLP-induced Tec translocation from the cytosol to the inner leaflet of the plasma membrane, and subsequently activation of phospholipase Cγ2 (PLCγ2). Moreover, MCL-1 attenuated PLCγ2 activity and intracellular calcium concentration notably through extracellular calcium influx. Consequently, fMLP-induced phosphorylation of protein kinase C (PKC) and membrane localization of p47(phox) were decreased by MCL-1 in a Tec-dependent manner, while the phosphorylation of extracellular signal-regulated kinase (ERK), p38, AKT and Src tyrosine kinase family remained unaffected. In addition, MCL-1 neither inhibited NADPH oxidase activity nor increased cyclicAMP levels. MCL-1 specific opposes fMLP-mediated respiratory burst by inhibition of membrane localization of Tec and subsequently interfered with the activation of PLCγ2, protein kinase C, and p47(phox). Copyright © 2012 Elsevier Inc. All rights reserved.

  7. TEC global mapping techniques

    International Nuclear Information System (INIS)

    Hernandez-Pajares, M.; Juan, J.M.; Sanz, J.; Orus, R.; Garcia-Fernandez, M.

    2002-01-01

    As is well known, many GNSS users are using single frequency receivers in their applications. These types of receivers are not able to correct directly the delay produced in the ionosphere, that can reach values of tens of meters. To overcome this problem there are several models that can be used to correct this ionospheric term: the GPS Broadcast model available with the GPS navigation message, empirical models like the IRI, and GPS data driven models, the last ones are being computed since June 1998 by the IGS Associate Analysis Centers (CODE, EMR, ESA, JPL and UPC). These models have different performances and can be or not suitable depending on the desired accuracy for each given application. A comparative study of such models is discussed in this paper, by comparing with independent ionospheric estimates provided by the TOPEX/Poseidon dual frequency altimeter. New improvements of the ionospheric correction algorithms using GPS data, for real-time and precise navigation purposes, will also be studied. (author)

  8. Content identification: binary content fingerprinting versus binary content encoding

    Science.gov (United States)

    Ferdowsi, Sohrab; Voloshynovskiy, Svyatoslav; Kostadinov, Dimche

    2014-02-01

    In this work, we address the problem of content identification. We consider content identification as a special case of multiclass classification. The conventional approach towards identification is based on content fingerprinting where a short binary content description known as a fingerprint is extracted from the content. We propose an alternative solution based on elements of machine learning theory and digital communications. Similar to binary content fingerprinting, binary content representation is generated based on a set of trained binary classifiers. We consider several training/encoding strategies and demonstrate that the proposed system can achieve the upper theoretical performance limits of content identification. The experimental results were carried out both on a synthetic dataset with different parameters and the FAMOS dataset of microstructures from consumer packages.

  9. Isolated ionospheric disturbances as deduced from global GPS network

    Directory of Open Access Journals (Sweden)

    E. L. Afraimovich

    2004-01-01

    Full Text Available We investigate an unusual class of medium-scale traveling ionospheric disturbances of the nonwave type, isolated ionospheric disturbances (IIDs that manifest themselves in total electron content (TEC variations in the form of single aperiodic negative TEC disturbances of a duration of about 10min (the total electron content spikes, TECS. The data were obtained using the technology of global detection of ionospheric disturbances using measurements of TEC variations from a global network of receivers of the GPS. For the first time, we present the TECS morphology for 170 days in 1998–2001. The total number of TEC series, with a duration of each series of about 2.3h (2h18m, exceeded 850000. It was found that TECS are observed in no more than 1–2% of the total number of TEC series mainly in the nighttime in the spring and autumn periods. The TECS amplitude exceeds the mean value of the "background" TEC variation amplitude by a factor of 5–10 as a minimum. TECS represent a local phenomenon with a typical radius of spatial correlation not larger than 500km. The IID-induced TEC variations are similar in their amplitude, form and duration to the TEC response to shock-acoustic waves (SAW generated during rocket launchings and earthquakes. However, the IID propagation velocity is less than the SAW velocity (800–1000m/s and are most likely to correspond to the velocity of background medium-scale acoustic-gravity waves, on the order of 100–200m/s. Key words. Ionosphere (ionospheric irregularities, instruments and techniques - Radio science (ionospheric propagation

  10. Field trial of efficacy of the Leish-tec® vaccine against canine leishmaniasis caused by Leishmania infantum in an endemic area with high transmission rates

    Science.gov (United States)

    Teva, Antonio; dos-Santos, Claudiney B.; Santos, Fernanda Nunes; Pinto, Israel de-Souza; Fux, Blima; Leite, Gustavo Rocha; Falqueto, Aloísio

    2017-01-01

    Background Because domestic dogs are reservoir hosts for visceral leishmaniasis (VL) in Brazil, one of the approaches used to reduce human disease incidence is to cull infected dogs. However, the results of controlled intervention trials based on serological screening of dogs and killing of seropositive animals are equivocal. A prophylactic vaccine to protect dogs from being infectious to the sand fly vector could be an effective strategy to provide sustained control. Here, we investigated whether a currently licensed commercial subunit rA2 protein–saponin vaccine (Leish-tec®) had an additional effect to dog culling on reducing the canine infectious populations. Methodology/Principal findings This prospective study was conducted in an L. infantum highly endemic area of southeast Brazil. At the onset of the intervention, all of the eligible dogs received through subcutaneous route a three-dose vaccine course at 21-day intervals and a booster on month 12. For the purpose of comparison, newly recruited healthy dogs were included as the exposed control group. To ascertain vaccine-induced protection, dogs were screened on clinical and serological criteria every 6 months for a 2-year follow-up period. Antibody-based tests and histopathological examination of post-mortem tissue specimens from euthanized animals were used as a marker of infection. The standardized vaccine regime, apart from being safe, was immunogenic as immunized animals responded with a pronounced production of anti-A2-specific IgG antibodies. It should be noted the mean seroconversion time for infection obtained among immunized exposed dogs (~ 18 months), which was twice as high as that for unvaccinated ones (~ 9 months). After two transmission cycles completed, the cumulative incidence of infection did differ significantly (P = 0.016) between the vaccinated (27%) and unvaccinated (42%) dogs. However, the expected efficacy for the vaccine in inducing clinical protection was not evident since 43% of

  11. Field trial of efficacy of the Leish-tec® vaccine against canine leishmaniasis caused by Leishmania infantum in an endemic area with high transmission rates.

    Directory of Open Access Journals (Sweden)

    Gabriel Grimaldi

    Full Text Available Because domestic dogs are reservoir hosts for visceral leishmaniasis (VL in Brazil, one of the approaches used to reduce human disease incidence is to cull infected dogs. However, the results of controlled intervention trials based on serological screening of dogs and killing of seropositive animals are equivocal. A prophylactic vaccine to protect dogs from being infectious to the sand fly vector could be an effective strategy to provide sustained control. Here, we investigated whether a currently licensed commercial subunit rA2 protein-saponin vaccine (Leish-tec® had an additional effect to dog culling on reducing the canine infectious populations.This prospective study was conducted in an L. infantum highly endemic area of southeast Brazil. At the onset of the intervention, all of the eligible dogs received through subcutaneous route a three-dose vaccine course at 21-day intervals and a booster on month 12. For the purpose of comparison, newly recruited healthy dogs were included as the exposed control group. To ascertain vaccine-induced protection, dogs were screened on clinical and serological criteria every 6 months for a 2-year follow-up period. Antibody-based tests and histopathological examination of post-mortem tissue specimens from euthanized animals were used as a marker of infection. The standardized vaccine regime, apart from being safe, was immunogenic as immunized animals responded with a pronounced production of anti-A2-specific IgG antibodies. It should be noted the mean seroconversion time for infection obtained among immunized exposed dogs (~ 18 months, which was twice as high as that for unvaccinated ones (~ 9 months. After two transmission cycles completed, the cumulative incidence of infection did differ significantly (P = 0.016 between the vaccinated (27% and unvaccinated (42% dogs. However, the expected efficacy for the vaccine in inducing clinical protection was not evident since 43% of vaccine recipients developed

  12. Field trial of efficacy of the Leish-tec® vaccine against canine leishmaniasis caused by Leishmania infantum in an endemic area with high transmission rates.

    Science.gov (United States)

    Grimaldi, Gabriel; Teva, Antonio; Dos-Santos, Claudiney B; Santos, Fernanda Nunes; Pinto, Israel de-Souza; Fux, Blima; Leite, Gustavo Rocha; Falqueto, Aloísio

    2017-01-01

    Because domestic dogs are reservoir hosts for visceral leishmaniasis (VL) in Brazil, one of the approaches used to reduce human disease incidence is to cull infected dogs. However, the results of controlled intervention trials based on serological screening of dogs and killing of seropositive animals are equivocal. A prophylactic vaccine to protect dogs from being infectious to the sand fly vector could be an effective strategy to provide sustained control. Here, we investigated whether a currently licensed commercial subunit rA2 protein-saponin vaccine (Leish-tec®) had an additional effect to dog culling on reducing the canine infectious populations. This prospective study was conducted in an L. infantum highly endemic area of southeast Brazil. At the onset of the intervention, all of the eligible dogs received through subcutaneous route a three-dose vaccine course at 21-day intervals and a booster on month 12. For the purpose of comparison, newly recruited healthy dogs were included as the exposed control group. To ascertain vaccine-induced protection, dogs were screened on clinical and serological criteria every 6 months for a 2-year follow-up period. Antibody-based tests and histopathological examination of post-mortem tissue specimens from euthanized animals were used as a marker of infection. The standardized vaccine regime, apart from being safe, was immunogenic as immunized animals responded with a pronounced production of anti-A2-specific IgG antibodies. It should be noted the mean seroconversion time for infection obtained among immunized exposed dogs (~ 18 months), which was twice as high as that for unvaccinated ones (~ 9 months). After two transmission cycles completed, the cumulative incidence of infection did differ significantly (P = 0.016) between the vaccinated (27%) and unvaccinated (42%) dogs. However, the expected efficacy for the vaccine in inducing clinical protection was not evident since 43% of vaccine recipients developed disease over

  13. First-line treatment of advanced ovarian cancer with paclitaxel/carboplatin with or without epirubicin (TEC versus TC)-a gynecologic cancer intergroup study of the NSGO, EORTC GCG and NCIC CTG

    DEFF Research Database (Denmark)

    Lindemann, K.; Christensen, R. D.; Vergote, I.

    2012-01-01

    phase III study comparing carboplatin plus paclitaxel (TC; area under the curve 5 and 175 mg/m(2)) with the same combination and epirubicin (TEC; 75 mg/m(2) i.v.). Between March 1999 and August 2001, 887 patients with epithelial ovarian, tubal or peritoneal cancer International Federation of Gynecology...

  14. Electronic Cigarettes

    Science.gov (United States)

    ... New FDA Regulations Text Size: A A A Electronic Cigarettes Electronic cigarettes (e-cigarettes) are battery operated products designed to ... more about: The latest news and events about electronic cigarettes on this FDA page Electronic cigarette basics on ...

  15. Electronic technology

    International Nuclear Information System (INIS)

    Kim, Jin Su

    2010-07-01

    This book is composed of five chapters, which introduces electronic technology about understanding of electronic, electronic component, radio, electronic application, communication technology, semiconductor on its basic, free electron and hole, intrinsic semiconductor and semiconductor element, Diode such as PN junction diode, characteristic of junction diode, rectifier circuit and smoothing circuit, transistor on structure of transistor, characteristic of transistor and common emitter circuit, electronic application about electronic equipment, communication technology and education, robot technology and high electronic technology.

  16. The Electron

    Energy Technology Data Exchange (ETDEWEB)

    Thomson, George

    1972-01-01

    Electrons are elementary particles of atoms that revolve around and outside the nucleus and have a negative charge. This booklet discusses how electrons relate to electricity, some applications of electrons, electrons as waves, electrons in atoms and solids, the electron microscope, among other things.

  17. Hard electronics; Hard electronics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    Hard material technologies were surveyed to establish the hard electronic technology which offers superior characteristics under hard operational or environmental conditions as compared with conventional Si devices. The following technologies were separately surveyed: (1) The device and integration technologies of wide gap hard semiconductors such as SiC, diamond and nitride, (2) The technology of hard semiconductor devices for vacuum micro- electronics technology, and (3) The technology of hard new material devices for oxides. The formation technology of oxide thin films made remarkable progress after discovery of oxide superconductor materials, resulting in development of an atomic layer growth method and mist deposition method. This leading research is expected to solve such issues difficult to be easily realized by current Si technology as high-power, high-frequency and low-loss devices in power electronics, high temperature-proof and radiation-proof devices in ultimate electronics, and high-speed and dense- integrated devices in information electronics. 432 refs., 136 figs., 15 tabs.

  18. Multimedia content classification metrics for content adaptation

    OpenAIRE

    Fernandes, Rui; Andrade, M.T.

    2015-01-01

    Multimedia content consumption is very popular nowadays. However, not every content can be consumed in its original format: the combination of content, transport and access networks, consumption device and usage environment characteristics may all pose restrictions to that purpose. One way to provide the best possible quality to the user is to adapt the content according to these restrictions as well as user preferences. This adaptation stage can be best executed if knowledge about the conten...

  19. Multimedia content classification metrics for content adaptation

    OpenAIRE

    Fernandes, Rui; Andrade, M.T.

    2016-01-01

    Multimedia content consumption is very popular nowadays. However, not every content can be consumed in its original format: the combination of content, transport and access networks, consumption device and usage environment characteristics may all pose restrictions to that purpose. One way to provide the best possible quality to the user is to adapt the content according to these restrictions as well as user preferences. This adaptation stage can be best executed if knowledge about the conten...

  20. Electron beam irradiation to the allogeneic, xenogenic and synthetic bone materials

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Soung Min; Park, Min Woo; Jeong, Hyun Oh [School of Dentistry Seoul National University, Seoul (Korea, Republic of); and others

    2013-07-01

    For the development of the biocompatible bony regeneration materials, allogenic, xenogenic and synthetic bone were irradiated by electron beam to change the basic components and structures. For the efficient electron beam irradiating condition of these allogenic, xenogenic and artificial bone substitutes, the optimal electron beam energy and their individual dose were established, to maximize the bony regeneration capacity. Commercial products of four allogenic bones, such as Accell (ISOTIS OrthogBiologics Co., USA), Allotis (Korea Bone Bank Co., Korea), Oragraft (LifeNet Co., USA), and Orthoblast (Integra Orthobiologics Inc., USA), six xenogenic bones, such as BBP (OscoTec Co., Korea), Bio-cera (OscoTec Co., Korea), Bio-oss (Geistlich Pharma AG, Switzerland), Indu-cera (OscoTec Co., Korea), OCS-B (Nibec Co., Korea), and OCS-H (Nibec Co., Korea), and six synthetic bones, such as BMP (Couellmedi Co., Korea), BoneMedik (Meta Biomed Co., Korea), Bone plus (Megagen Co., Korea), MBCP (Biomatlante Co., France), Osteon (Genoss Co., Korea), and Osteogen (Impladent LTD., USA), were used. We used 1.0 and 2.0 MeV superconduction accelerator, and/or microtrone with different individual 60, 120 kGy irradiation dose. Different dose irradiated specimens were divided 6 portions each, so total 360 groups were prepared. 4 portions were analyzed each by elementary analysis using FE-SEM (Field Emission Scanning Microscopy) and another 2 portions were grafted to the calvarial defect of Sprague-Dawley rat, following histologic, immunohistochemical analysis and TEM study were processed at the 8th and 16th weeks, in vivo. This work was supported by the National Research Foundation of Korea(NRF) grant funded by the Korea government(MEST)

  1. Ionospheric responses during equinox and solstice periods over Turkey

    Science.gov (United States)

    Karatay, Secil; Cinar, Ali; Arikan, Feza

    2017-11-01

    Ionospheric electron density is the determining variable for investigation of the spatial and temporal variations in the ionosphere. Total Electron Content (TEC) is the integral of the electron density along a ray path that indicates the total variability through the ionosphere. Global Positioning System (GPS) recordings can be utilized to estimate the TEC, thus GPS proves itself as a useful tool in monitoring the total variability of electron distribution within the ionosphere. This study focuses on the analysis of the variations of ionosphere over Turkey that can be grouped into anomalies during equinox and solstice periods using TEC estimates obtained by a regional GPS network. It is observed that noon time depletions in TEC distributions predominantly occur in winter for minimum Sun Spots Numbers (SSN) in the central regions of Turkey which also exhibit high variability due to midlatitude winter anomaly. TEC values and ionospheric variations at solstice periods demonstrate significant enhancements compared to those at equinox periods.

  2. Momona Ethiopian Journal of Science - Vol 9, No 2 (2017)

    African Journals Online (AJOL)

    Global Variations of Ionospheric Total Electron Content (TEC) Derived from GPS Global Ionospheric Maps · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Hintsa Gebreselasse, Gebregiorgis Abraha, 141-161 ...

  3. CDDIS_GNSS_products_ionosphere_predicted

    Data.gov (United States)

    National Aeronautics and Space Administration — Ionosphere Total Electron Content (TEC) grids derived from analysis of Global Navigation Satellite System (GNSS) data. These products are the generated by analysis...

  4. CDDIS_GNSS_products_ionosphere_rapid

    Data.gov (United States)

    National Aeronautics and Space Administration — Ionosphere Total Electron Content (TEC) grids derived from analysis of Global Navigation Satellite System (GNSS) data. These products are the generated by analysis...

  5. Electron radiography

    Science.gov (United States)

    Merrill, Frank E.; Morris, Christopher

    2005-05-17

    A system capable of performing radiography using a beam of electrons. Diffuser means receive a beam of electrons and diffuse the electrons before they enter first matching quadrupoles where the diffused electrons are focused prior to the diffused electrons entering an object. First imaging quadrupoles receive the focused diffused electrons after the focused diffused electrons have been scattered by the object for focusing the scattered electrons. Collimator means receive the scattered electrons and remove scattered electrons that have scattered to large angles. Second imaging quadrupoles receive the collimated scattered electrons and refocus the collimated scattered electrons and map the focused collimated scattered electrons to transverse locations on an image plane representative of the electrons' positions in the object.

  6. Teaching Students to Correspond Effectively Electronically.

    Science.gov (United States)

    Extejt, Marian M.

    1998-01-01

    Discusses current standards for formatting and etiquette of electronic mail in the business setting. Discusses privacy and appropriate content. Notes that class assignments involving electronic mail provide practical opportunities to develop ease with this form. (SR)

  7. Electron detector

    International Nuclear Information System (INIS)

    Hashimoto, H.; Mogami, A.

    1975-01-01

    A device for measuring electron densities at a given energy level in an electron beam or the like having strong background noise, for example, in the detection of Auger electric energy spectrums is described. An electron analyzer passes electrons at the given energy level and at the same time electrons of at least one adjacent energy level. Detecting means associated therewith produce signals indicative of the densities of the electrons at each energy level and combine these signals to produce a signal indicative of the density of the electrons of the given energy level absent background noise

  8. Introduction to electron beam processing

    International Nuclear Information System (INIS)

    Waichiro Kawakami

    1994-01-01

    The contents are general features in the irradiation of polymers, electron beam machines - low energy, medium energy, high energy; application of EB machine in industries, engineering of EB processing, dosimetry of EB (electron beam) safe operation of EB machine, recent topics on EB processing under development. 3 tabs., 4 figs., 17 refs

  9. Obtención de un mejorador de suelos como subproducto de la digestión anaerobia de desechos orgánicos en el TEC Obtention of a soil improver as subproduct from the anaerobic digestion of organic residues at the Technological Institute of Costa Rica

    Directory of Open Access Journals (Sweden)

    Margie Faith Vargas

    2012-11-01

    Full Text Available El tratamiento anaerobio de los desechos orgánicos permite obtener efluentes con propiedades biofertilizantes, además de biogás para la generación de energía renovable. El objetivo del presente estudio fue evaluar una mezcla de los efluentes de dos biodigestores a escala en elTEC para determinar su potencial uso como bioabono. Se analizó la composición química y se encontró que el proceso de biodigestión aumentó el contenido de nutrientes. Se determinó la calidad microbiológica y se observó una disminución en el recuento de coliformes fecales pero no se alcanzó la concentración bacteriana mínima para garantizar una aplicación inocua a los cultivos de consumo directo. Por otra parte, se realizaron ensayos en invernadero, aplicando tres tratamientos al cultivo de lechuga (Lactuca sativa. El primero consistió en fertilizar el cultivo con la mezcla de efluentes concentrada, el segundo con la mezcla diluida al 50% y el tercero con un fertilizante químico. Se analizó la altura de las plantas, el número de hojas, el peso fresco y el peso seco. Se encontraron diferencias estadísticamente significativas para las tres primeras variables, pero no para la última. Se concluyó que el fertilizante químico produjo mejores resultados en el corto plazo, y que la aplicación del efluente diluido al 50% fue más efectiva que al 100%. Se recomienda utilizar los efluentes de los biodigestores a escala del TEC como mejoradores de suelos, tomando las medidas necesarias para garantizar su inocuidad.Anaerobic treatment of organic wastes generates effluents with biofer tilizer proper ties, besides biogas for renewable energy production. The purpose of this research was to evaluate a mixture of effluents obtained from two small scale biodigesters at the TEC, with the purpose of determining its potential use as biofertilizer. We analyzed the chemical composition and found an increase in the nutrient content of the effluents after biodigestion. We

  10. Electron/electron acoustic instability

    International Nuclear Information System (INIS)

    Gary, S.P.

    1987-01-01

    The electron acoustic wave becomes a normal mode of an unmagnetized collisionless plasma in the presence of two electron components with similar densities, but strongly disparate temperatures. The characteristic frequency of this mode is the plasma frequency of the cooler electron component. If these two electron components have a relative drift speed several times the thermal speed of the cooler component, the electron/electron acoustic instability may arise. This paper describes the parametric dependences of the threshold drift speed and maximum growth rate of this instability, and compares these with the same properties of the electron/ion acoustic instability. Under the condition of zero current, the electron/ion acoustic instability typically has the lower threshold drift speed, so that observation of the electron/electron acoustic instability is a strong indication of the presence of an electrical current in the plasma

  11. Electron Microscopy.

    Science.gov (United States)

    Beer, Michael

    1980-01-01

    Reviews technical aspects of structure determination in biological