WorldWideScience

Sample records for elastic tissue

  1. Biomimetic heterogenous elastic tissue development.

    Science.gov (United States)

    Tsai, Kai Jen; Dixon, Simon; Hale, Luke Richard; Darbyshire, Arnold; Martin, Daniel; de Mel, Achala

    2017-01-01

    There is an unmet need for artificial tissue to address current limitations with donor organs and problems with donor site morbidity. Despite the success with sophisticated tissue engineering endeavours, which employ cells as building blocks, they are limited to dedicated labs suitable for cell culture, with associated high costs and long tissue maturation times before available for clinical use. Direct 3D printing presents rapid, bespoke, acellular solutions for skull and bone repair or replacement, and can potentially address the need for elastic tissue, which is a major constituent of smooth muscle, cartilage, ligaments and connective tissue that support organs. Thermoplastic polyurethanes are one of the most versatile elastomeric polymers. Their segmented block copolymeric nature, comprising of hard and soft segments allows for an almost limitless potential to control physical properties and mechanical behaviour. Here we show direct 3D printing of biocompatible thermoplastic polyurethanes with Fused Deposition Modelling, with a view to presenting cell independent in-situ tissue substitutes. This method can expeditiously and economically produce heterogenous, biomimetic elastic tissue substitutes with controlled porosity to potentially facilitate vascularisation. The flexibility of this application is shown here with tubular constructs as exemplars. We demonstrate how these 3D printed constructs can be post-processed to incorporate bioactive molecules. This efficacious strategy, when combined with the privileges of digital healthcare, can be used to produce bespoke elastic tissue substitutes in-situ, independent of extensive cell culture and may be developed as a point-of-care therapy approach.

  2. Hyperplasia of elastic tissue in hepatic schistosomal fibrosis

    Directory of Open Access Journals (Sweden)

    Zilton A. Andrade

    1991-12-01

    Full Text Available Elastic tissue hyperplasia, revealed by means of histological, immunocytochemical and ultrastructural methods, appeared as a prominent change in surgical liver biopsies taken from 61 patients with schistosomal periportal and septal fibrosis. Such hyperplasia was absent in ecperimental murine schistosomiasis, including mice with "pipe-stem" fibrosis. Displaced connective tissue cells in periportal areas, such as smooth muscle cells, more frequently observed in human material, could be the site of excessive elastin synthesis, and could explain the differences observed in human and experimental materials. Elastic tissue, sometimes represented by its microfibrillar components, also appeared to be more condensed in areas of matrix (collagen degradation, suggesting a participation of this tissue in the remodelling of the extracellular matrix. By its rectratile properties elastic tissue hyperplasia in hepatic schistosomiasis can cause vascular narrowing and thus play a role in the pathogenesis of portal hypeertension.

  3. Automatic estimation of elasticity parameters in breast tissue

    Science.gov (United States)

    Skerl, Katrin; Cochran, Sandy; Evans, Andrew

    2014-03-01

    Shear wave elastography (SWE), a novel ultrasound imaging technique, can provide unique information about cancerous tissue. To estimate elasticity parameters, a region of interest (ROI) is manually positioned over the stiffest part of the shear wave image (SWI). The aim of this work is to estimate the elasticity parameters i.e. mean elasticity, maximal elasticity and standard deviation, fully automatically. Ultrasonic SWI of a breast elastography phantom and breast tissue in vivo were acquired using the Aixplorer system (SuperSonic Imagine, Aix-en-Provence, France). First, the SWI within the ultrasonic B-mode image was detected using MATLAB then the elasticity values were extracted. The ROI was automatically positioned over the stiffest part of the SWI and the elasticity parameters were calculated. Finally all values were saved in a spreadsheet which also contains the patient's study ID. This spreadsheet is easily available for physicians and clinical staff for further evaluation and so increase efficiency. Therewith the efficiency is increased. This algorithm simplifies the handling, especially for the performance and evaluation of clinical trials. The SWE processing method allows physicians easy access to the elasticity parameters of the examinations from their own and other institutions. This reduces clinical time and effort and simplifies evaluation of data in clinical trials. Furthermore, reproducibility will be improved.

  4. Shear Elasticity and Shear Viscosity Imaging in Soft Tissue

    Science.gov (United States)

    Yang, Yiqun

    In this thesis, a new approach is introduced that provides estimates of shear elasticity and shear viscosity using time-domain measurements of shear waves in viscoelastic media. Simulations of shear wave particle displacements induced by an acoustic radiation force are accelerated significantly by a GPU. The acoustic radiation force is first calculated using the fast near field method (FNM) and the angular spectrum approach (ASA). The shear waves induced by the acoustic radiation force are then simulated in elastic and viscoelastic media using Green's functions. A parallel algorithm is developed to perform these calculations on a GPU, where the shear wave particle displacements at different observation points are calculated in parallel. The resulting speed increase enables rapid evaluation of shear waves at discrete points, in 2D planes, and for push beams with different spatial samplings and for different values of the f-number (f/#). The results of these simulations show that push beams with smaller f/# require a higher spatial sampling rate. The significant amount of acceleration achieved by this approach suggests that shear wave simulations with the Green's function approach are ideally suited for high-performance GPUs. Shear wave elasticity imaging determines the mechanical parameters of soft tissue by analyzing measured shear waves induced by an acoustic radiation force. To estimate the shear elasticity value, the widely used time-of-flight method calculates the correlation between shear wave particle velocities at adjacent lateral observation points. Although this method provides accurate estimates of the shear elasticity in purely elastic media, our experience suggests that the time-of-flight (TOF) method consistently overestimates the shear elasticity values in viscoelastic media because the combined effects of diffraction, attenuation, and dispersion are not considered. To address this problem, we have developed an approach that directly accounts for all

  5. Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment.

    Science.gov (United States)

    Lyra-Leite, Davi M; Andres, Allen M; Petersen, Andrew P; Ariyasinghe, Nethika R; Cho, Nathan; Lee, Jezell A; Gottlieb, Roberta A; McCain, Megan L

    2017-10-01

    Mitochondria in cardiac myocytes are critical for generating ATP to meet the high metabolic demands associated with sarcomere shortening. Distinct remodeling of mitochondrial structure and function occur in cardiac myocytes in both developmental and pathological settings. However, the factors that underlie these changes are poorly understood. Because remodeling of tissue architecture and extracellular matrix (ECM) elasticity are also hallmarks of ventricular development and disease, we hypothesize that these environmental factors regulate mitochondrial function in cardiac myocytes. To test this, we developed a new procedure to transfer tunable polydimethylsiloxane disks microcontact-printed with fibronectin into cell culture microplates. We cultured Sprague-Dawley neonatal rat ventricular myocytes within the wells, which consistently formed tissues following the printed fibronectin, and measured oxygen consumption rate using a Seahorse extracellular flux analyzer. Our data indicate that parameters associated with baseline metabolism are predominantly regulated by ECM elasticity, whereas the ability of tissues to adapt to metabolic stress is regulated by both ECM elasticity and tissue alignment. Furthermore, bioenergetic health index, which reflects both the positive and negative aspects of oxygen consumption, was highest in aligned tissues on the most rigid substrate, suggesting that overall mitochondrial function is regulated by both ECM elasticity and tissue alignment. Our results demonstrate that mitochondrial function is regulated by both ECM elasticity and myofibril architecture in cardiac myocytes. This provides novel insight into how extracellular cues impact mitochondrial function in the context of cardiac development and disease. NEW & NOTEWORTHY A new methodology has been developed to measure O 2 consumption rates in engineered cardiac tissues with independent control over tissue alignment and matrix elasticity. This led to the findings that matrix

  6. Elastic properties of synthetic materials for soft tissue modeling

    International Nuclear Information System (INIS)

    Mansy, H A; Grahe, J R; Sandler, R H

    2008-01-01

    Mechanical models of soft tissue are useful for studying vibro-acoustic phenomena. They may be used for validating mathematical models and for testing new equipment and techniques. The objective of this study was to measure density and visco-elastic properties of synthetic materials that can be used to build such models. Samples of nine different materials were tested under dynamic (0.5 Hz) compressive loading conditions. The modulus of elasticity of the materials was varied, whenever possible, by adding a softener during manufacturing. The modulus was measured over a nine month period to quantify the effect of ageing and softener loss on material properties. Results showed that a wide range of the compression elasticity modulus (10 to 1400 kPa) and phase (3.5 0 -16.7 0 ) between stress and strain were possible. Some materials tended to exude softener over time, resulting in a weight loss and elastic properties change. While the weight loss under normal conditions was minimal in all materials (<3% over nine months), loss under accelerated weight-loss conditions can reach 59%. In the latter case an elasticity modulus increase of up to 500% was measured. Key advantages and limitations of candidate materials were identified and discussed

  7. The role of an effective isotropic tissue modulus in the elastic properties of cancellous bone

    NARCIS (Netherlands)

    Kabel, J.; Rietbergen, van B.; Dalstra, M.; Odgaard, A.; Huiskes, H.W.J.

    1999-01-01

    Conceptually, the elastic characteristics of cancellous bone could be predicted directly from the trabecular morphology-or architecture-and by the elastic properties of the tissue itself. Although hardly any experimental evidence exists, it is often implicitly assumed that tissue anisotropy has a

  8. Ultrasound Shear Wave Simulation of Breast Tumor Using Nonlinear Tissue Elasticity

    Directory of Open Access Journals (Sweden)

    Dae Woo Park

    2016-01-01

    Full Text Available Shear wave elasticity imaging (SWEI can assess the elasticity of tissues, but the shear modulus estimated in SWEI is often less sensitive to a subtle change of the stiffness that produces only small mechanical contrast to the background tissues. Because most soft tissues exhibit mechanical nonlinearity that differs in tissue types, mechanical contrast can be enhanced if the tissues are compressed. In this study, a finite element- (FE- based simulation was performed for a breast tissue model, which consists of a circular (D: 10 mm, hard tumor and surrounding tissue (soft. The SWEI was performed with 0% to 30% compression of the breast tissue model. The shear modulus of the tumor exhibited noticeably high nonlinearity compared to soft background tissue above 10% overall applied compression. As a result, the elastic modulus contrast of the tumor to the surrounding tissue was increased from 0.46 at 0% compression to 1.45 at 30% compression.

  9. Ultrasound Shear Wave Simulation of Breast Tumor Using Nonlinear Tissue Elasticity.

    Science.gov (United States)

    Park, Dae Woo

    2015-01-01

    Shear wave elasticity imaging (SWEI) can assess the elasticity of tissues, but the shear modulus estimated in SWEI is often less sensitive to a subtle change of the stiffness that produces only small mechanical contrast to the background tissues. Because most soft tissues exhibit mechanical nonlinearity that differs in tissue types, mechanical contrast can be enhanced if the tissues are compressed. In this study, a finite element- (FE-) based simulation was performed for a breast tissue model, which consists of a circular (D: 10 mm, hard) tumor and surrounding tissue (soft). The SWEI was performed with 0% to 30% compression of the breast tissue model. The shear modulus of the tumor exhibited noticeably high nonlinearity compared to soft background tissue above 10% overall applied compression. As a result, the elastic modulus contrast of the tumor to the surrounding tissue was increased from 0.46 at 0% compression to 1.45 at 30% compression.

  10. Numerical computing of elastic homogenized coefficients for periodic fibrous tissue

    Directory of Open Access Journals (Sweden)

    Roman S.

    2009-06-01

    Full Text Available The homogenization theory in linear elasticity is applied to a periodic array of cylindrical inclusions in rectangular pattern extending to infinity in the inclusions axial direction, such that the deformation of tissue along this last direction is negligible. In the plane of deformation, the homogenization scheme is based on the average strain energy whereas in the third direction it is based on the average normal stress along this direction. Namely, these average quantities have to be the same on a Repeating Unit Cell (RUC of heterogeneous and homogenized media when using a special form of boundary conditions forming by a periodic part and an affine part of displacement. It exists an infinity of RUCs generating the considered array. The computing procedure is tested with different choices of RUC to control that the results of the homogenization process are independent of the kind of RUC we employ. Then, the dependence of the homogenized coefficients on the microstructure can be studied. For instance, a special anisotropy and the role of the inclusion volume are investigated. In the second part of this work, mechanical traction tests are simulated. We consider two kinds of loading, applying a density of force or imposing a displacement. We test five samples of periodic array containing one, four, sixteen, sixty-four and one hundred of RUCs. The evolution of mean stresses, strains and energy with the numbers of inclusions is studied. Evolutions depend on the kind of loading, but not their limits, which could be predicted by simulating traction test of the homogenized medium.

  11. Periodontal tissue destruction caused by an elastic orthodontic ...

    African Journals Online (AJOL)

    Once this cooperation is lost, possible negative effects may be the consequence. ... that arises when elastic orthodontic spacers are being used in the mouth. Key words: Open-flap curettage, Orthodontic spacer, Periodontal destruction ...

  12. Elastic cavitation, tube hollowing, and differential growth in plants and biological tissues

    KAUST Repository

    Goriely, A.

    2010-07-01

    Elastic cavitation is a well-known physical process by which elastic materials under stress can open cavities. Usually, cavitation is induced by applied loads on the elastic body. However, growing materials may generate stresses in the absence of applied loads and could induce cavity opening. Here, we demonstrate the possibility of spontaneous growth-induced cavitation in elastic materials and consider the implications of this phenomenon to biological tissues and in particular to the problem of schizogenous aerenchyma formation. Copyright © EPLA, 2010.

  13. Contribution of elastic tissues to the mechanics and energetics of muscle function during movement.

    Science.gov (United States)

    Roberts, Thomas J

    2016-01-01

    Muscle force production occurs within an environment of tissues that exhibit spring-like behavior, and this elasticity is a critical determinant of muscle performance during locomotion. Muscle force and power output both depend on the speed of contraction, as described by the isotonic force-velocity curve. By influencing the speed of contractile elements, elastic structures can have a profound effect on muscle force, power and work. In very rapid movements, elastic mechanisms can amplify muscle power by storing the work of muscle contraction slowly and releasing it rapidly. When energy must be dissipated rapidly, such as in landing from a jump, energy stored rapidly in elastic elements can be released more slowly to stretch muscle contractile elements, reducing the power input to muscle and possibly protecting it from damage. Elastic mechanisms identified so far rely primarily on in-series tendons, but many structures within muscles exhibit spring-like properties. Actomyosin cross-bridges, actin and myosin filaments, titin, and the connective tissue scaffolding of the extracellular matrix all have the potential to store and recover elastic energy during muscle contraction. The potential contribution of these elements can be assessed from their stiffness and estimates of the strain they undergo during muscle function. Such calculations provide boundaries for the possible roles these springs might play in locomotion, and may help to direct future studies of the uses of elastic elements in muscle. © 2016. Published by The Company of Biologists Ltd.

  14. A focused air-pulse system for optical-coherence-tomography-based measurements of tissue elasticity

    International Nuclear Information System (INIS)

    Wang, Shang; Larin, K V; Li, Jiasong; Vantipalli, S; Twa, M D; Manapuram, R K; Aglyamov, S; Emelianov, S

    2013-01-01

    Accurate non-invasive assessment of tissue elasticity in vivo is required for early diagnostics of many tissue abnormalities. We have developed a focused air-pulse system that produces a low-pressure and short-duration air stream, which can be used to excite transient surface waves (SWs) in soft tissues. System characteristics were studied using a high-resolution analog pressure transducer to describe the excitation pressure. Results indicate that the excitation pressure provided by the air-pulse system can be easily controlled by the air source pressure, the angle of delivery, and the distance between the tissue surface and the port of the air-pulse system. Furthermore, we integrated this focused air-pulse system with phase-sensitive optical coherence tomography (PhS-OCT) to make non-contact measurements of tissue elasticity. The PhS-OCT system is used to assess the group velocity of SW propagation, which can be used to determine Young’s modulus. Pilot experiments were performed on gelatin phantoms with different concentrations (10%, 12% and 14% w/w). The results demonstrate the feasibility of using this focused air-pulse system combined with PhS-OCT to estimate tissue elasticity. This easily controlled non-contact technique is potentially useful to study the biomechanical properties of ocular and other tissues in vivo. (letter)

  15. Flexible and elastic porous poly(trimethylene carbonate) structures for use in vascular tissue engineering

    NARCIS (Netherlands)

    Song, Y.; Kamphuis, Marloes; Zhang Zheng, Z.Z.; Zhang, Z.; Sterk, L.M.Th.; Vermes, I.; Poot, Andreas A.; Feijen, Jan; Grijpma, Dirk W.

    Biocompatible and elastic porous tubular structures based on poly(1,3-trimethylene carbonate), PTMC, were developed as scaffolds for tissue engineering of small-diameter blood vessels. High-molecular-weight PTMC (Mn = 4.37 × 105) was cross-linked by gamma-irradiation in an inert nitrogen atmosphere.

  16. The link between tissue elasticity and thermal dose in vivo

    International Nuclear Information System (INIS)

    Sapin-de Brosses, Emilie; Pernot, Mathieu; Tanter, Mickaël

    2011-01-01

    The objective of this study was to investigate in vivo the relationship between stiffness and thermal dose. For this purpose, shear wave elastography (SWE)—a novel ultrasound-based technique for real-time mapping of the stiffness of biological soft tissues—is performed in temperature-controlled experiments. Experiments were conducted on nine anesthetized rats. Their right leg was put in a thermo-regulated waterbath. The right leg of each animal was heated at one particular temperature between 38 °C and 48.5 °C for 15 min to 3 h. Shear waves were generated in the muscle using the acoustic radiation force induced by a linear ultrasonic probe. The shear wave propagation was imaged in real time by the probe using an ultrafast scanner prototype (10 000 frames s −1 ). The local tissue stiffness was derived from the shear wave speed. Two optical fiber sensors were inserted into the muscle to measure in situ the temperature. Stiffness was found to increase strongly during the experiments. When expressed as a function of the thermal dose, the stiffness curves were found to be the same for all experiments. A thermal dose threshold was found at 202 min for an eightfold stiffness increase. Finally, the time–temperature relationship was established for different stiffness ratios. The slope of the time–temperature relationship based on stiffness measurements was found identical to the one obtained for cell death in the seminal paper on the thermal dose by Sapareto and Dewey in 1984 (Int. J. Radiat. Oncol. Biol. Phys. 10 787–800). The present results highlight the stiffness increase as a good indicator of thermal necrosis. SWE imaging can be used in vivo for necrosis threshold determination in thermal therapy.

  17. Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling.

    Science.gov (United States)

    Zajac, Allison L; Discher, Dennis E

    2008-12-01

    Cells may lack eyes to see and ears to hear, but cells do seem to have a sense of 'touch' that allows them to feel their microenvironment. This is achieved in part through contractility coupled adhesion to physically flexible 'soft' tissue. Here we summarize some of the known variations in elasticity of solid tissue and review some of the long-term effects of cells 'feeling' this elasticity, focusing on differentiation processes of both committed cell types and stem cells. We then highlight what is known of molecular remodeling in cells under stress on short time scales. Key roles for forces generated by ubiquitous and essential myosin-II motors in feedback remodeling are emphasized throughout.

  18. Collagen and elastic fibers of skin connective tissue in patients with and without primary inguinal hernia

    OpenAIRE

    Bórquez M, Pablo; Garrido O, Luis; Manterola D, Carlos; Peña S, Patricio; Schlageter T, Carol; Orellana C, Juan José; Ulloa U, Hugo; Peña R, Juan Luis

    2003-01-01

    There are few studies looking for collagen matrix defects in patients with inguinal hernia. Aim: To study the skin connective tissue in patients with and without inguinal hernia. Patients and methods: Skin from the surgical wound was obtained from 23 patients with and 23 patients without inguinal hernia. The samples were processed for conventional light microscopy. Collagen fibers were stained with Van Giesson and elastic fibers with Weigert stain. Results: Patients without hernia had compact...

  19. Longitudinal elastic properties and porosity of cortical bone tissue vary with age in human proximal femur.

    Science.gov (United States)

    Malo, M K H; Rohrbach, D; Isaksson, H; Töyräs, J; Jurvelin, J S; Tamminen, I S; Kröger, H; Raum, K

    2013-04-01

    Tissue level structural and mechanical properties are important determinants of bone strength. As an individual ages, microstructural changes occur in bone, e.g., trabeculae and cortex become thinner and porosity increases. However, it is not known how the elastic properties of bone change during aging. Bone tissue may lose its elasticity and become more brittle and prone to fractures as it ages. In the present study the age-dependent variation in the spatial distributions of microstructural and microelastic properties of the human femoral neck and shaft were evaluated by using acoustic microscopy. Although these properties may not be directly measured in vivo, there is a major interest to investigate their relationships with the linear elastic measurements obtained by diagnostic ultrasound at the most severe fracture sites, e.g., the femoral neck. However, before the validity of novel in vivo techniques can be established, it is essential to understand the age-dependent variation in tissue elastic properties and porosity at different skeletal sites. A total of 42 transverse cross-sectional bone samples were obtained from the femoral neck (Fn) and proximal femoral shaft (Ps) of 21 men (mean±SD age 47.1±17.8, range 17-82years). Samples were quantitatively imaged using a scanning acoustic microscope (SAM) equipped with a 50MHz ultrasound transducer. Distributions of the elastic coefficient (c33) of cortical (Ct) and trabecular (Tr) tissues and microstructure of cortex (cortical thickness Ct.Th and porosity Ct.Po) were determined. Variations in c33 were observed with respect to tissue type (c33Trc33(Ct.Fn)=35.3GPa>c33(Tr.Ps)=33.8GPa>c33(Tr.Fn)=31.9GPa), and cadaver age (R(2)=0.28-0.46, pbone tissue were observed. These findings may explain in part the increase in susceptibility to suffer low energy fractures during aging and highlight the potential of ultrasound in clinical osteoporosis diagnostics. Copyright © 2013 Elsevier Inc. All rights reserved.

  20. Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples

    International Nuclear Information System (INIS)

    Samani, Abbas; Zubovits, Judit; Plewes, Donald

    2007-01-01

    Understanding and quantifying the mechanical properties of breast tissues has been a subject of interest for the past two decades. This has been motivated in part by interest in modelling soft tissue response for surgery planning and virtual-reality-based surgical training. Interpreting elastography images for diagnostic purposes also requires a sound understanding of normal and pathological tissue mechanical properties. Reliable data on tissue elastic properties are very limited and those which are available tend to be inconsistent, in part as a result of measurement methodology. We have developed specialized techniques to measure tissue elasticity of breast normal tissues and tumour specimens and applied them to 169 fresh ex vivo breast tissue samples including fat and fibroglandular tissue as well as a range of benign and malignant breast tumour types. Results show that, under small deformation conditions, the elastic modulus of normal breast fat and fibroglandular tissues are similar while fibroadenomas were approximately twice the stiffness. Fibrocystic disease and malignant tumours exhibited a 3-6-fold increased stiffness with high-grade invasive ductal carcinoma exhibiting up to a 13-fold increase in stiffness compared to fibrogalndular tissue. A statistical analysis showed that differences between the elastic modulus of the majority of those tissues were statistically significant. Implications for the specificity advantages of elastography are reviewed

  1. Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples

    Energy Technology Data Exchange (ETDEWEB)

    Samani, Abbas [Department of Medical Biophysics/Electrical and Computer Engineering, University of Western Ontario, Medical Sciences Building, London, Ontario, N6A 5C1 (Canada); Zubovits, Judit [Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 (Canada); Plewes, Donald [Department of Medical Biophysics, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5 (Canada)

    2007-03-21

    Understanding and quantifying the mechanical properties of breast tissues has been a subject of interest for the past two decades. This has been motivated in part by interest in modelling soft tissue response for surgery planning and virtual-reality-based surgical training. Interpreting elastography images for diagnostic purposes also requires a sound understanding of normal and pathological tissue mechanical properties. Reliable data on tissue elastic properties are very limited and those which are available tend to be inconsistent, in part as a result of measurement methodology. We have developed specialized techniques to measure tissue elasticity of breast normal tissues and tumour specimens and applied them to 169 fresh ex vivo breast tissue samples including fat and fibroglandular tissue as well as a range of benign and malignant breast tumour types. Results show that, under small deformation conditions, the elastic modulus of normal breast fat and fibroglandular tissues are similar while fibroadenomas were approximately twice the stiffness. Fibrocystic disease and malignant tumours exhibited a 3-6-fold increased stiffness with high-grade invasive ductal carcinoma exhibiting up to a 13-fold increase in stiffness compared to fibrogalndular tissue. A statistical analysis showed that differences between the elastic modulus of the majority of those tissues were statistically significant. Implications for the specificity advantages of elastography are reviewed.

  2. Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples

    Science.gov (United States)

    Samani, Abbas; Zubovits, Judit; Plewes, Donald

    2007-03-01

    Understanding and quantifying the mechanical properties of breast tissues has been a subject of interest for the past two decades. This has been motivated in part by interest in modelling soft tissue response for surgery planning and virtual-reality-based surgical training. Interpreting elastography images for diagnostic purposes also requires a sound understanding of normal and pathological tissue mechanical properties. Reliable data on tissue elastic properties are very limited and those which are available tend to be inconsistent, in part as a result of measurement methodology. We have developed specialized techniques to measure tissue elasticity of breast normal tissues and tumour specimens and applied them to 169 fresh ex vivo breast tissue samples including fat and fibroglandular tissue as well as a range of benign and malignant breast tumour types. Results show that, under small deformation conditions, the elastic modulus of normal breast fat and fibroglandular tissues are similar while fibroadenomas were approximately twice the stiffness. Fibrocystic disease and malignant tumours exhibited a 3-6-fold increased stiffness with high-grade invasive ductal carcinoma exhibiting up to a 13-fold increase in stiffness compared to fibrogalndular tissue. A statistical analysis showed that differences between the elastic modulus of the majority of those tissues were statistically significant. Implications for the specificity advantages of elastography are reviewed.

  3. Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity.

    Science.gov (United States)

    Liu, Yu; Liu, Jingfei; Fite, Brett Z; Foiret, Josquin; Ilovitsh, Asaf; Leach, J Kent; Dumont, Erik; Caskey, Charles F; Ferrara, Katherine W

    2017-05-21

    Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal. Also, strategies employing a series of discrete ultrasound pulses directed to increasing depths along a single line-of-sight have been designed to generate a quasi-planar shear wave. Such 'supersonic' excitations have been applied for ultrasound elasticity measurements. The resulting shear wave is higher in amplitude than that generated from a single excitation and the properties of the media are simply visualized and quantified due to the quasi-planar wave geometry and the opportunity to generate the wave at the site of interest. Here for the first time, we extend the application of supersonic methods by developing a protocol for supersonic transient magnetic resonance elastography (sst-MRE) using an MR-guided focused ultrasound system capable of therapeutic ablation. We apply the new protocol to quantify tissue elasticity in vitro using biologically-relevant inclusions and tissue-mimicking phantoms, compare the results with elasticity maps acquired with ultrasound shear wave elasticity imaging (US-SWEI), and validate both methods with mechanical testing. We found that a modified time-of-flight (TOF) method efficiently quantified shear modulus from sst-MRE data, and both the TOF and local inversion methods result in similar maps based on US-SWEI. With a three-pulse excitation, the proposed sst-MRE protocol was capable of visualizing quasi-planar shear waves propagating away from the excitation location and detecting differences in shear

  4. Supersonic transient magnetic resonance elastography for quantitative assessment of tissue elasticity

    Science.gov (United States)

    Liu, Yu; Liu, Jingfei; Fite, Brett Z.; Foiret, Josquin; Ilovitsh, Asaf; Leach, J. Kent; Dumont, Erik; Caskey, Charles F.; Ferrara, Katherine W.

    2017-05-01

    Non-invasive, quantitative methods to assess the properties of biological tissues are needed for many therapeutic and tissue engineering applications. Magnetic resonance elastography (MRE) has historically relied on external vibration to generate periodic shear waves. In order to focally assess a biomaterial or to monitor the response to ablative therapy, the interrogation of a specific region of interest by a focused beam is desirable and transient MRE (t-MRE) techniques have previously been developed to accomplish this goal. Also, strategies employing a series of discrete ultrasound pulses directed to increasing depths along a single line-of-sight have been designed to generate a quasi-planar shear wave. Such ‘supersonic’ excitations have been applied for ultrasound elasticity measurements. The resulting shear wave is higher in amplitude than that generated from a single excitation and the properties of the media are simply visualized and quantified due to the quasi-planar wave geometry and the opportunity to generate the wave at the site of interest. Here for the first time, we extend the application of supersonic methods by developing a protocol for supersonic transient magnetic resonance elastography (sst-MRE) using an MR-guided focused ultrasound system capable of therapeutic ablation. We apply the new protocol to quantify tissue elasticity in vitro using biologically-relevant inclusions and tissue-mimicking phantoms, compare the results with elasticity maps acquired with ultrasound shear wave elasticity imaging (US-SWEI), and validate both methods with mechanical testing. We found that a modified time-of-flight (TOF) method efficiently quantified shear modulus from sst-MRE data, and both the TOF and local inversion methods result in similar maps based on US-SWEI. With a three-pulse excitation, the proposed sst-MRE protocol was capable of visualizing quasi-planar shear waves propagating away from the excitation location and detecting differences in shear

  5. Elastic cavitation, tube hollowing, and differential growth in plants and biological tissues

    KAUST Repository

    Goriely, A.; Moulton, D. E.; Vandiver, R.

    2010-01-01

    Elastic cavitation is a well-known physical process by which elastic materials under stress can open cavities. Usually, cavitation is induced by applied loads on the elastic body. However, growing materials may generate stresses in the absence

  6. Measuring the linear and nonlinear elastic properties of brain tissue with shear waves and inverse analysis.

    Science.gov (United States)

    Jiang, Yi; Li, Guoyang; Qian, Lin-Xue; Liang, Si; Destrade, Michel; Cao, Yanping

    2015-10-01

    We use supersonic shear wave imaging (SSI) technique to measure not only the linear but also the nonlinear elastic properties of brain matter. Here, we tested six porcine brains ex vivo and measured the velocities of the plane shear waves induced by acoustic radiation force at different states of pre-deformation when the ultrasonic probe is pushed into the soft tissue. We relied on an inverse method based on the theory governing the propagation of small-amplitude acoustic waves in deformed solids to interpret the experimental data. We found that, depending on the subjects, the resulting initial shear modulus [Formula: see text] varies from 1.8 to 3.2 kPa, the stiffening parameter [Formula: see text] of the hyperelastic Demiray-Fung model from 0.13 to 0.73, and the third- [Formula: see text] and fourth-order [Formula: see text] constants of weakly nonlinear elasticity from [Formula: see text]1.3 to [Formula: see text]20.6 kPa and from 3.1 to 8.7 kPa, respectively. Paired [Formula: see text] test performed on the experimental results of the left and right lobes of the brain shows no significant difference. These values are in line with those reported in the literature on brain tissue, indicating that the SSI method, combined to the inverse analysis, is an efficient and powerful tool for the mechanical characterization of brain tissue, which is of great importance for computer simulation of traumatic brain injury and virtual neurosurgery.

  7. Evaluation of multimodality imaging using image fusion with ultrasound tissue elasticity imaging in an experimental animal model.

    Science.gov (United States)

    Paprottka, P M; Zengel, P; Cyran, C C; Ingrisch, M; Nikolaou, K; Reiser, M F; Clevert, D A

    2014-01-01

    To evaluate the ultrasound tissue elasticity imaging by comparison to multimodality imaging using image fusion with Magnetic Resonance Imaging (MRI) and conventional grey scale imaging with additional elasticity-ultrasound in an experimental small-animal-squamous-cell carcinoma-model for the assessment of tissue morphology. Human hypopharynx carcinoma cells were subcutaneously injected into the left flank of 12 female athymic nude rats. After 10 days (SD ± 2) of subcutaneous tumor growth, sonographic grey scale including elasticity imaging and MRI measurements were performed using a high-end ultrasound system and a 3T MR. For image fusion the contrast-enhanced MRI DICOM data set was uploaded in the ultrasonic device which has a magnetic field generator, a linear array transducer (6-15 MHz) and a dedicated software package (GE Logic E9), that can detect transducers by means of a positioning system. Conventional grey scale and elasticity imaging were integrated in the image fusion examination. After successful registration and image fusion the registered MR-images were simultaneously shown with the respective ultrasound sectional plane. Data evaluation was performed using the digitally stored video sequence data sets by two experienced radiologist using a modified Tsukuba Elasticity score. The colors "red and green" are assigned for an area of soft tissue, "blue" indicates hard tissue. In all cases a successful image fusion and plan registration with MRI and ultrasound imaging including grey scale and elasticity imaging was possible. The mean tumor volume based on caliper measurements in 3 dimensions was ~323 mm3. 4/12 rats were evaluated with Score I, 5/12 rates were evaluated with Score II, 3/12 rates were evaluated with Score III. There was a close correlation in the fused MRI with existing small necrosis in the tumor. None of the scored II or III lesions was visible by conventional grey scale. The comparison of ultrasound tissue elasticity imaging enables a

  8. Tissue quality assessment using a novel direct elasticity assessment device (the E-finger: a cadaveric study of prostatectomy dissection.

    Directory of Open Access Journals (Sweden)

    Daniel W Good

    Full Text Available Minimally invasive radical prostatectomy (RP (robotic and laparoscopic, have brought improvements in the outcomes of RP due to improved views and increased degrees of freedom of surgical devices. Robotic and laparoscopic surgeries do not incorporate haptic feedback, which may result in complications secondary to inadequate tissue dissection (causing positive surgical margins, rhabdosphincter damage, etc. We developed a micro-engineered device (6 mm2 sized [E-finger] capable of quantitative elasticity assessment, with amplitude ratio, mean ratio and phase lag representing this. The aim was to assess the utility of the device in differentiating peri-prostatic tissue types in order to guide prostate dissection.Two embalmed and 2 fresh frozen cadavers were used in the study. Baseline elasticity values were assessed in bladder, prostate and rhabdosphincter of pre-dissected embalmed cadavers using the micro-engineered device. A measurement grid was created to span from the bladder, across the prostate and onto the rhabdosphincter of fresh frozen cadavers to enable a systematic quantitative elasticity assessment of the entire area by 2 independent assessors. Tissue was sectioned along each row of elasticity measurement points, and stained with haematoxylin and eosin (H&E. Image analysis was performed with Image Pro Premier to determine the histology at each measurement point.Statistically significant differences in elasticity were identified between bladder, prostate and sphincter in both embalmed and fresh frozen cadavers (p = < 0.001. Intra-class correlation (ICC reliability tests showed good reliability (average ICC = 0.851. Sensitivity and specificity for tissue identification was 77% and 70% respectively to a resolution of 6 mm2.This cadaveric study has evaluated the ability of our elasticity assessment device to differentiate bladder, prostate and rhabdosphincter to a resolution of 6 mm2. The results provide useful data for which to continue to

  9. Measurement of tissue-radiation dosage using a thermal steady-state elastic shear wave.

    Science.gov (United States)

    Chang, Sheng-Yi; Hsieh, Tung-Sheng; Chen, Wei-Ru; Chen, Jin-Chung; Chou, Chien

    2017-08-01

    A biodosimeter based on thermal-induced elastic shear wave (TIESW) in silicone acellular porcine dermis (SAPD) at thermal steady state has been proposed and demonstrated. A square slab SAPD treated with ionizing radiation was tested. The SAPD becomes a continuous homogeneous and isotropic viscoelastic medium due to the generation of randomly coiled collagen fibers formed from their bundle-like structure in the dermis. A harmonic TIESW then propagates on the surface of the SAPD as measured by a nanometer-scaled strain-stress response under thermal equilibrium conditions at room temperature. TIESW oscillation frequency was noninvasively measured in real time by monitoring the transverse displacement of the TIESW on the SAPD surface. Because the elastic shear modulus is highly sensitive to absorbed doses of ionizing radiation, this proposed biodosimeter can become a highly sensitive and noninvasive method for quantitatively determining tissue-absorbed dosage in terms of TIESW’s oscillation frequency. Detection sensitivity at 1 cGy and dynamic ranges covering 1 to 40 cGy and 80 to 500 cGy were demonstrated.

  10. Refinement of elastic, poroelastic, and osmotic tissue properties of intervertebral disks to analyze behavior in compression.

    Science.gov (United States)

    Stokes, Ian A F; Laible, Jeffrey P; Gardner-Morse, Mack G; Costi, John J; Iatridis, James C

    2011-01-01

    Intervertebral disks support compressive forces because of their elastic stiffness as well as the fluid pressures resulting from poroelasticity and the osmotic (swelling) effects. Analytical methods can quantify the relative contributions, but only if correct material properties are used. To identify appropriate tissue properties, an experimental study and finite element analytical simulation of poroelastic and osmotic behavior of intervertebral disks were combined to refine published values of disk and endplate properties to optimize model fit to experimental data. Experimentally, nine human intervertebral disks with adjacent hemi-vertebrae were immersed sequentially in saline baths having concentrations of 0.015, 0.15, and 1.5 M and the loss of compressive force at constant height (force relaxation) was recorded over several hours after equilibration to a 300-N compressive force. Amplitude and time constant terms in exponential force-time curve-fits for experimental and finite element analytical simulations were compared. These experiments and finite element analyses provided data dependent on poroelastic and osmotic properties of the disk tissues. The sensitivities of the model to alterations in tissue material properties were used to obtain refined values of five key material parameters. The relaxation of the force in the three bath concentrations was exponential in form, expressed as mean compressive force loss of 48.7, 55.0, and 140 N, respectively, with time constants of 1.73, 2.78, and 3.40 h. This behavior was analytically well represented by a model having poroelastic and osmotic tissue properties with published tissue properties adjusted by multiplying factors between 0.55 and 2.6. Force relaxation and time constants from the analytical simulations were most sensitive to values of fixed charge density and endplate porosity.

  11. Tissue quality assessment using a novel direct elasticity assessment device (the E-finger): a cadaveric study of prostatectomy dissection.

    Science.gov (United States)

    Good, Daniel W; Khan, Ashfaq; Hammer, Steven; Scanlan, Paul; Shu, Wenmiao; Phipps, Simon; Parson, Simon H; Stewart, Grant D; Reuben, Robert; McNeill, S Alan

    2014-01-01

    Minimally invasive radical prostatectomy (RP) (robotic and laparoscopic), have brought improvements in the outcomes of RP due to improved views and increased degrees of freedom of surgical devices. Robotic and laparoscopic surgeries do not incorporate haptic feedback, which may result in complications secondary to inadequate tissue dissection (causing positive surgical margins, rhabdosphincter damage, etc). We developed a micro-engineered device (6 mm2 sized) [E-finger]) capable of quantitative elasticity assessment, with amplitude ratio, mean ratio and phase lag representing this. The aim was to assess the utility of the device in differentiating peri-prostatic tissue types in order to guide prostate dissection. Two embalmed and 2 fresh frozen cadavers were used in the study. Baseline elasticity values were assessed in bladder, prostate and rhabdosphincter of pre-dissected embalmed cadavers using the micro-engineered device. A measurement grid was created to span from the bladder, across the prostate and onto the rhabdosphincter of fresh frozen cadavers to enable a systematic quantitative elasticity assessment of the entire area by 2 independent assessors. Tissue was sectioned along each row of elasticity measurement points, and stained with haematoxylin and eosin (H&E). Image analysis was performed with Image Pro Premier to determine the histology at each measurement point. Statistically significant differences in elasticity were identified between bladder, prostate and sphincter in both embalmed and fresh frozen cadavers (p = elasticity assessment device to differentiate bladder, prostate and rhabdosphincter to a resolution of 6 mm2. The results provide useful data for which to continue to examine the use of elasticity assessment devices for tissue quality assessment with the aim of giving haptic feedback to surgeons performing complex surgery.

  12. Bioreactor-induced mesenchymal progenitor cell differentiation and elastic fiber assembly in engineered vascular tissues.

    Science.gov (United States)

    Lin, Shigang; Mequanint, Kibret

    2017-09-01

    In vitro maturation of engineered vascular tissues (EVT) requires the appropriate incorporation of smooth muscle cells (SMC) and extracellular matrix (ECM) components similar to native arteries. To this end, the aim of the current study was to fabricate 4mm inner diameter vascular tissues using mesenchymal progenitor cells seeded into tubular scaffolds. A dual-pump bioreactor operating either in perfusion or pulsatile perfusion mode was used to generate physiological-like stimuli to promote progenitor cell differentiation, extracellular elastin production, and tissue maturation. Our data demonstrated that pulsatile forces and perfusion of 3D tubular constructs from both the lumenal and ablumenal sides with culture media significantly improved tissue assembly, effectively inducing mesenchymal progenitor cell differentiation to SMCs with contemporaneous elastin production. With bioreactor cultivation, progenitor cells differentiated toward smooth muscle lineage characterized by the expression of smooth muscle (SM)-specific markers smooth muscle alpha actin (SM-α-actin) and smooth muscle myosin heavy chain (SM-MHC). More importantly, pulsatile perfusion bioreactor cultivation enhanced the synthesis of tropoelastin and its extracellular cross-linking into elastic fiber compared with static culture controls. Taken together, the current study demonstrated progenitor cell differentiation and vascular tissue assembly, and provides insights into elastin synthesis and assembly to fibers. Incorporation of elastin into engineered vascular tissues represents a critical design goal for both mechanical and biological functions. In the present study, we seeded porous tubular scaffolds with multipotent mesenchymal progenitor cells and cultured in dual-pump pulsatile perfusion bioreactor. Physiological-like stimuli generated by bioreactor not only induced mesenchymal progenitor cell differentiation to vascular smooth muscle lineage but also actively promoted elastin synthesis and

  13. Determination of the Elasticity of Breast Tissue during the Menstrual Cycle Using Real-Time Shear Wave Elastography.

    Science.gov (United States)

    Li, Xiang; Wang, Jian-Nan; Fan, Zhi-Ying; Kang, Shu; Liu, Yan-Jun; Zhang, Yi-Xia; Wang, Xue-Mei

    2015-12-01

    We examined breast tissue elasticity during the menstrual cycle using real-time shear wave elastography (RT-SWE), a recent technique developed for soft tissue imaging. Written informed consent for RT-SWE was obtained from all eligible patients, who were healthy women aged between 19 and 52 y. Young's moduli of the breast tissue in the early follicular, late phase and luteal phase were compared. There were no significant differences in the mean, maximum and minimum elasticity values (Emean, Emax and Emin) and standard deviation (ESD). RT-SWE of glandular tissue revealed that ESD was increased in the early follicular phase compared with the luteal phase. Means ± SD of Emin, Emax and Emean in glandular tissue were 5.174 ± 2.138, 8.308 ± 3.166 and 6.593 ± 2.510, respectively, and in adipose tissue, 3.589 ± 2.083, 6.733 ± 3.522 and 4.857 ± 2.564, respectively. There were no significant differences in stiffness between glandular and adipose tissues throughout the menstrual cycle, but glandular tissue stiffness was lower in the luteal phase than in the early follicular phase. On the basis of these observations in normal healthy women, we believe we have obtained sufficient information to establish the baseline changes in human breast elasticity during the menstrual cycle. In the future, we intend to compare the elasticity values of healthy breast tissue with those of breast tissue affected by various pathologies. Our results reveal the significant potential of RT-SWE in the rapid and non-invasive clinical diagnosis of breast diseases, such as breast cancers. Copyright © 2015 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  14. An examination of the elastic properties of tissue-mimicking phantoms using vibro-acoustography and a muscle motor system

    Science.gov (United States)

    Maccabi, A.; Taylor, Z.; Bajwa, N.; Mallen-St. Clair, J.; St. John, M.; Sung, S.; Grundfest, W.; Saddik, G.

    2016-02-01

    Tissue hardness, often quantified in terms of elasticity, is an important differentiating criterion for pathological identity and is extensively used by surgeons for tumor localization. Delineation of malignant regions from benign regions is typically performed by visual inspection and palpation. Although practical, this method is highly subjective and does not provide quantitative metrics. We have previously reported on Vibro-Acoustography (VA) for tumor delineation. VA is unique in that it uses the specific, non-linear properties of tumor tissue in response to an amplitude modulated ultrasound beam to generate spatially resolved, high contrast maps of tissue. Although the lateral and axial resolutions (sub-millimeter and sub-centimeter, respectively) of VA have been extensively characterized, the relationship between static stiffness assessment (palpation) and dynamic stiffness characterization (VA) has not been explicitly established. Here we perform a correlative exploration of the static and dynamic properties of tissue-mimicking phantoms, specifically elasticity, using VA and a muscle motor system. Muscle motor systems, commonly used to probe the mechanical properties of materials, provide absolute, quantitative point measurements of the elastic modulus, analogous to Young's modulus, of a target. For phantoms of varying percent-by-weight concentrations, parallel VA and muscle motor studies conducted on 18 phantoms reveal a negative correlation (p < - 0.85) between mean signal amplitude levels observed with VA and calculated elastic modulus values from force vs. indentation depth curves. Comparison of these elasticity measurements may provide additional information to improve tissue modeling, system characterization, as well as offer valuable insights for in vivo applications, specifically surgical extirpation of tumors.

  15. A virtual surgical training system that simulates cutting of soft tissue using a modified pre-computed elastic model.

    Science.gov (United States)

    Toe, Kyaw Kyar; Huang, Weimin; Yang, Tao; Duan, Yuping; Zhou, Jiayin; Su, Yi; Teo, Soo-Kng; Kumar, Selvaraj Senthil; Lim, Calvin Chi-Wan; Chui, Chee Kong; Chang, Stephen

    2015-08-01

    This work presents a surgical training system that incorporates cutting operation of soft tissue simulated based on a modified pre-computed linear elastic model in the Simulation Open Framework Architecture (SOFA) environment. A precomputed linear elastic model used for the simulation of soft tissue deformation involves computing the compliance matrix a priori based on the topological information of the mesh. While this process may require a few minutes to several hours, based on the number of vertices in the mesh, it needs only to be computed once and allows real-time computation of the subsequent soft tissue deformation. However, as the compliance matrix is based on the initial topology of the mesh, it does not allow any topological changes during simulation, such as cutting or tearing of the mesh. This work proposes a way to modify the pre-computed data by correcting the topological connectivity in the compliance matrix, without re-computing the compliance matrix which is computationally expensive.

  16. Mechanical characterization and non-linear elastic modeling of poly(glycerol sebacate) for soft tissue engineering.

    Science.gov (United States)

    Mitsak, Anna G; Dunn, Andrew M; Hollister, Scott J

    2012-07-01

    Scaffold tissue engineering strategies for repairing and replacing soft tissue aim to improve reconstructive and corrective surgical techniques whose limitations include suboptimal mechanical properties, fibrous capsule formation and volume loss due to graft resorption. An effective tissue engineering strategy requires a scaffolding material with low elastic modulus that behaves similarly to soft tissue, which has been characterized as a nonlinear elastic material. The material must also have the ability to be manufactured into specifically designed architectures. Poly(glycerol sebacate) (PGS) is a thermoset elastomer that meets these criteria. We hypothesize that the mechanical properties of PGS can be modulated through curing condition and architecture to produce materials with a range of stiffnesses. To evaluate this hypothesis, we manufactured PGS constructs cured under various conditions and having one of two architectures (solid or porous). Specimens were then tensile tested according to ASTM standards and the data were modeled using a nonlinear elastic Neo-Hookean model. Architecture and testing conditions, including elongation rate and wet versus dry conditions, affected the mechanical properties. Increasing curing time and temperature led to increased tangent modulus and decreased maximum strain for solid constructs. Porous constructs had lower nonlinear elastic properties, as did constructs of both architectures tested under simulated physiological conditions (wetted at 37 °C). Both solid and porous PGS specimens could be modeled well with the Neo-Hookean model. Future studies include comparing PGS properties to other biological tissue types and designing and characterizing PGS scaffolds for regenerating these tissues. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Chemo-mechanical modeling of tumor growth in elastic epithelial tissue

    Energy Technology Data Exchange (ETDEWEB)

    Bratsun, Dmitry A., E-mail: bratsun@pspu.ru [Department of Applied Physics, Perm National Research Polytechnical University, Perm, 614990 (Russian Federation); Zakharov, Andrey P. [Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, 32000 Israel (Israel); Theoretical Physics Department, Perm State Humanitarian Pedagogical University, Perm, 614990 (Russian Federation); Pismen, Len [Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, 32000 Israel (Israel)

    2016-08-02

    We propose a multiscale chemo-mechanical model of the cancer tumor development in the epithelial tissue. The epithelium is represented by an elastic 2D array of polygonal cells with its own gene regulation dynamics. The model allows the simulation of the evolution of multiple cells interacting via the chemical signaling or mechanically induced strain. The algorithm includes the division and intercalation of cells as well as the transformation of normal cells into a cancerous state triggered by a local failure of the spatial synchronization of the cellular rhythms driven by transcription/translation processes. Both deterministic and stochastic descriptions of the system are given for chemical signaling. The transformation of cells means the modification of their respective parameters responsible for chemo-mechanical interactions. The simulations reproduce a distinct behavior of invasive and localized carcinoma. Generally, the model is designed in such a way that it can be readily modified to take account of any newly understood gene regulation processes and feedback mechanisms affecting chemo-mechanical properties of cells.

  18. Chemo-mechanical modeling of tumor growth in elastic epithelial tissue

    Science.gov (United States)

    Bratsun, Dmitry A.; Zakharov, Andrey P.; Pismen, Len

    2016-08-01

    We propose a multiscale chemo-mechanical model of the cancer tumor development in the epithelial tissue. The epithelium is represented by an elastic 2D array of polygonal cells with its own gene regulation dynamics. The model allows the simulation of the evolution of multiple cells interacting via the chemical signaling or mechanically induced strain. The algorithm includes the division and intercalation of cells as well as the transformation of normal cells into a cancerous state triggered by a local failure of the spatial synchronization of the cellular rhythms driven by transcription/translation processes. Both deterministic and stochastic descriptions of the system are given for chemical signaling. The transformation of cells means the modification of their respective parameters responsible for chemo-mechanical interactions. The simulations reproduce a distinct behavior of invasive and localized carcinoma. Generally, the model is designed in such a way that it can be readily modified to take account of any newly understood gene regulation processes and feedback mechanisms affecting chemo-mechanical properties of cells.

  19. [Study of collagen and elastic fibers of connective tissue in patients with and without primary inguinal hernia].

    Science.gov (United States)

    Bórquez, Pablo; Garrido, Luis; Manterola, Carlos; Peña, Patricio; Schlageter, Carol; Orellana, Juan José; Ulloa, Hugo; Peña, Juan Luis

    2003-11-01

    There are few studies looking for collagen matrix defects in patients with inguinal bernia. To study the skin connective tissue in patients with and without inguinal bernia. Skin from the surgical wound was obtained from 23 patients with and 23 patients without inguinal bernia. The samples were processed for conventional light microscopy. Collagen fibers were stained with Van Giesson and elastic fibers with Weigert stain. Patients without hernia had compact collagen tracts homogeneously distributed towards the deep dermis. In contrast, patients with hernia had zones in the dermis with thinner and disaggregated collagen tracts. Connective tissue had a lax aspect in these patients. Collagen fiber density was 52% lower in patients with hernia, compared to subjects without hernia. No differences in elastic fiber density or distribution was observed between groups. Patients with inguinal bernia have alterations in skin collagen fiber quality and density.

  20. Tissue elasticity of in vivo skeletal muscles measured in the transverse and longitudinal planes using shear wave elastography.

    Science.gov (United States)

    Chino, Kentaro; Kawakami, Yasuo; Takahashi, Hideyuki

    2017-07-01

    The aim of the present study was to measure in vivo skeletal muscle elasticity in the transverse and longitudinal planes using shear wave elastography and then to compare the image stability, measurement values and measurement repeatability between these imaging planes. Thirty-one healthy males participated in this study. Tissue elasticity (shear wave velocity) of the medial gastrocnemius, rectus femoris, biceps brachii and rectus abdominis was measured in both the transverse and longitudinal planes using shear wave elastography. Image stability was evaluated by the standard deviation of the colour distribution in the shear wave elastography image. Measurement repeatability was assessed by the coefficient of variance obtained from three measurement values. Image stability of all tested muscles was significantly higher in the longitudinal plane (Pplanes (P>0·05), except in the biceps brachii (P = 0·001). Measurement values of the medial gastrocnemius, rectus femoris and biceps brachii were significantly different between the imaging planes (Pplane, which indicates that imaging plane should be considered when measuring skeletal muscle tissue elasticity by shear wave elastography. © 2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

  1. Preliminary Study on the Kidney Elasticity Quantification in Patients With Chronic Kidney Disease Using Virtual Touch Tissue Quantification

    International Nuclear Information System (INIS)

    Zheng, Xiao Zhi; Yang, Bin; Fu, Ning Hua

    2015-01-01

    Virtual touch tissue quantification (VTTQ) provides numerical measurements (shear wave velocity (SWV) values) of tissue stiffness. The purpose of this study was to describe the SWV values of the kidney by VTTQ and to examine the clinical usefulness of this procedure in the evaluation of elasticity changes in the kidneys of patients with chronic kidney disease (CKD). Sixty-five patients with CKD and seventy healthy participants were included in this study. A total of 270 kidneys were examined by VTTQ. The kidney elasticity was expressed as shear wave velocity. The SWV values, blood serum creatinine (Scr)/BUN and pathological findings were analyzed and compared between patients with CKD and healthy participants. In patients with CKD and healthy participants, the SWV values both gradually decreased from the renal cortex to the medulla and renal sinus The SWV value of the renal cortex in patients with CKD was less than that of healthy participants (P < 0.05), and the SWV value of the renal cortex in patients with renal insufficiency was significantly less than in those with normal renal function (2.46 ± 0.15 vs. 3.45 ± 0.26 m/s, P < 0.05). The best cutoff value for predicting renal insufficiency (Scr > 1.24 mg/dL or/and BUN > 21 mg/DL) was a SWV value of the renal cortex of less than 1.92 m/s with a sensitivity of 84.4% (95% CI: 67.2-94.7%) and a specificity of 96.8% (95% CI: 83.3-99.9%) (P < 0.001). VTTQ can sensitively detect the elasticity changes in patients with CKD, and it can effectively predict renal insufficiency. This technology provides a valuable tool for the assessment of CKD

  2. Characterization of elasticity and hydration of composite hydrogel based on collagen-iota carrageenan as a corneal tissue engineering

    Science.gov (United States)

    Rinawati, M.; Triastuti, J.; Pursetyo, K. T.

    2018-04-01

    The cornea is a refractive element of the eye that serves to continue the stimulation of light into the eye it has a clear, transparent, elastic and relatively thick tissue. Factors caused corneal blindness, are dystrophy, keratoconus, corneal scaring. Hydrogels can be made from polysaccharide derivatives that have gelation properties such as iota carrageenan. Therefore, it is a need to develop composite hydrogel based collagen-iota carragenan as an engineeried corneal tissue with high elasticity and hydration properties. Collagen hydrogel has a maximum water content an has equlibrium up to 40 %, less than the human cornea, 81 % and under normal hydration conditions, the human cornea can transmit 87 % of visible light. In addition, the refractive index on the surface of the cornea with air is 1.375-1.380. Based on this study, it is necessary to conduct research on the development and composition of hydrogel composite collagen-iota carrageen hydrogen based on. The best result was K5 (5:5) treatment, which has the equilibrium water content of 87.07 % and viscosity of 10.7346 Pa.s.

  3. Study of effective atomic number of breast tissues determined using the elastic to inelastic scattering ratio

    Energy Technology Data Exchange (ETDEWEB)

    Antoniassi, M.; Conceicao, A.L.C. [Departamento de Fisica e Matematica, Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo (Brazil); Poletti, M.E., E-mail: poletti@ffclrp.usp.br [Departamento de Fisica e Matematica, Faculdade de Filosofia Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo (Brazil)

    2011-10-01

    In this work we have measured Compton and Rayleigh scattering radiation from normal (adipose and fibroglandular), benign (fibroadenoma) and malignant (ductal carcinoma) breast tissues using a monoenergetic beam of 17.44 keV and a scattering angle of 90{sup o} (x=0.99 A{sup -1}). A practical method using the area of Rayleigh and Compton scattering was used for determining the effective atomic number (Z{sub eff}) of the samples, being validated through measurements of several reference materials. The results show that there are differences in the distributions of Z{sub eff} of breast tissues, which are mainly related to the elemental composition of carbon (Z=6) and oxygen (Z=8) of each tissue type. The results suggest that is possible to use the method to characterize the breast tissues permitting study histological features of the breast tissues related to their elemental composition.

  4. Study of effective atomic number of breast tissues determined using the elastic to inelastic scattering ratio

    International Nuclear Information System (INIS)

    Antoniassi, M.; Conceicao, A.L.C.; Poletti, M.E.

    2011-01-01

    In this work we have measured Compton and Rayleigh scattering radiation from normal (adipose and fibroglandular), benign (fibroadenoma) and malignant (ductal carcinoma) breast tissues using a monoenergetic beam of 17.44 keV and a scattering angle of 90 o (x=0.99 A -1 ). A practical method using the area of Rayleigh and Compton scattering was used for determining the effective atomic number (Z eff ) of the samples, being validated through measurements of several reference materials. The results show that there are differences in the distributions of Z eff of breast tissues, which are mainly related to the elemental composition of carbon (Z=6) and oxygen (Z=8) of each tissue type. The results suggest that is possible to use the method to characterize the breast tissues permitting study histological features of the breast tissues related to their elemental composition.

  5. Study of effective atomic number of breast tissues determined using the elastic to inelastic scattering ratio

    Science.gov (United States)

    Antoniassi, M.; Conceição, A. L. C.; Poletti, M. E.

    2011-10-01

    In this work we have measured Compton and Rayleigh scattering radiation from normal (adipose and fibroglandular), benign (fibroadenoma) and malignant (ductal carcinoma) breast tissues using a monoenergetic beam of 17.44 keV and a scattering angle of 90° ( x=0.99 Å -1). A practical method using the area of Rayleigh and Compton scattering was used for determining the effective atomic number ( Zeff) of the samples, being validated through measurements of several reference materials. The results show that there are differences in the distributions of Zeff of breast tissues, which are mainly related to the elemental composition of carbon ( Z=6) and oxygen ( Z=8) of each tissue type. The results suggest that is possible to use the method to characterize the breast tissues permitting study histological features of the breast tissues related to their elemental composition.

  6. Virtual touch tissue quantification of acoustic radiation force impulse: a new ultrasound elastic imaging in the diagnosis of thyroid nodules.

    Directory of Open Access Journals (Sweden)

    Yi-Feng Zhang

    Full Text Available OBJECTIVE: Virtual touch tissue quantification (VTQ of acoustic radiation force impulse (ARFI is a new quantitative technique to measure tissue stiffness. The study was aimed to assess the usefulness of VTQ in the diagnosis of thyroid nodules. METHODS: 173 pathologically proven thyroid nodules in 142 patients were included and all were examined by conventional ultrasound (US, conventional elasticity imaging (EI and VTQ of ARFI. The tissue stiffness for VTQ was expressed as shear wave velocity (SWV (m/s. Receiver-operating characteristic curve (ROC analyses were performed to assess the diagnostic performance. Intra- and inter-observer reproducibility of VTQ measurement was assessed. RESULTS: The SWVs of benign and malignant thyroid nodules were 2.34±1.17 m/s (range: 0.61-9.00 m/s and 4.82±2.53 m/s (range: 2.32-9.00 m/s respectively (P20 mm and lowest for those ≤10 mm. The correlation coefficients were 0.904 for intraobserver measurement and 0.864 for interobserver measurement. CONCLUSIONS: VTQ of ARFI provides quantitative and reproducible information about the tissue stiffness, which is useful for the differentiation between benign and malignant thyroid nodules. The diagnostic performance of VTQ is higher than that of conventional EI.

  7. Analysis of sports related mTBI injuries caused by elastic wave propagation through brain tissue

    Directory of Open Access Journals (Sweden)

    D Case

    2016-10-01

    Full Text Available Repetitive concussions and sub-concussions suffered by athletes have been linked to a series of sequelae ranging from traumatic encephalopathy to dementia pugilistica. A detailed finite element model of the human head was developed based on standard libraries of medical imaging. The model includes realistic material properties for the brain tissue, bone, soft tissue, and CSF, as well as the structure and properties of a protective helmet. Various impact scenarios were studied, with a focus on the strains/stresses and pressure gradients and concentrations created in the brain tissue due to propagation of waves produced by the impact through the complex internal structure of the human head. This approach has the potential to expand our understanding of the mechanism of brain injury, and to better assess the risk of delayed neurological disorders for tens of thousands of young athletes throughout the world.

  8. Fiber/collagen composites for ligament tissue engineering: influence of elastic moduli of sparse aligned fibers on mesenchymal stem cells.

    Science.gov (United States)

    Thayer, Patrick S; Verbridge, Scott S; Dahlgren, Linda A; Kakar, Sanjeev; Guelcher, Scott A; Goldstein, Aaron S

    2016-08-01

    Electrospun microfibers are attractive for the engineering of oriented tissues because they present instructive topographic and mechanical cues to cells. However, high-density microfiber networks are too cell-impermeable for most tissue applications. Alternatively, the distribution of sparse microfibers within a three-dimensional hydrogel could present instructive cues to guide cell organization while not inhibiting cell behavior. In this study, thin (∼5 fibers thick) layers of aligned microfibers (0.7 μm) were embedded within collagen hydrogels containing mesenchymal stem cells (MSCs), cultured for up to 14 days, and assayed for expression of ligament markers and imaged for cell organization. These microfibers were generated through the electrospinning of polycaprolactone (PCL), poly(ester-urethane) (PEUR), or a 75/25 PEUR/PCL blend to produce microfiber networks with elastic moduli of 31, 15, and 5.6 MPa, respectively. MSCs in composites containing 5.6 MPa fibers exhibited increased expression of the ligament marker scleraxis and the contractile phenotype marker α-smooth muscle actin versus the stiffer fiber composites. Additionally, cells within the 5.6 MPa microfiber composites were more oriented compared to cells within the 15 and 31 MPa microfiber composites. Together, these data indicate that the mechanical properties of microfiber/collagen composites can be tuned for the engineering of ligament and other target tissues. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1894-1901, 2016. © 2016 Wiley Periodicals, Inc.

  9. [Effect of elastic strain rate ratio method and virtual touch tissue quantification on the diagnosis of breast masses].

    Science.gov (United States)

    Gong, LiJie; He, Yan; Tian, Peng; Yan, Yan

    2016-07-01

    To determine the effect of elastic strain rate ratio method and virtual touch tissue quantification (VTQ) on the diagnosis of breast masses.
 Sixty female patients with breast cancer, who received surgical treatment in Daqing Oilfield General Hospital, were enrolled. All patients signed the informed consent paperwork and they were treated by routine ultrasound examination, compression elastography (CE) examination, and VTQ examination in turn. Strain ratio (SR) was checked by CE and shear wave velocity (SWV) value was measured by VTQ. The diagnostic values of different methods were evaluated by receiver operating characteristic (ROC) curves in the diagnosis of benign and malignant breast tumors.
 The maximum diameter and SWV value of the benign tumors were lower than those of the malignant tumors, and the SR ratio of benign masses was higher than that of malignant tumors (Pbreast mass than that used alone.

  10. Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system.

    Science.gov (United States)

    Wang, Shang; Li, Jiasong; Manapuram, Ravi Kiran; Menodiado, Floredes M; Ingram, Davis R; Twa, Michael D; Lazar, Alexander J; Lev, Dina C; Pollock, Raphael E; Larin, Kirill V

    2012-12-15

    We report on an optical noncontact method for the detection of soft-tissue tumors based on the measurement of their elasticity. A focused air-puff system is used to excite surface waves (SWs) on soft tissues with transient static pressure. A high-speed phase-sensitive optical coherence tomography system is used to measure the SWs as they propagate from the point of excitation. To evaluate the stiffness of soft tissues, the Young's modulus is quantified based on the group velocity of SWs. Pilot experiments were performed on ex vivo human myxoma and normal fat. Results demonstrate the feasibility of the proposed method to measure elasticity and differentiate soft-tissue tumors from normal tissues.

  11. A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage

    DEFF Research Database (Denmark)

    Day, J; Ding, Ming; van der Linden, JC

    2001-01-01

    determined using a combination of finite element models and mechanical testing. The bone tissue modulus was reduced by 60% in the medial condyle of the cases with cartilage damage compared to the control specimens. Neither the presence of cartilage damage nor the anatomic site (medial vs. lateral) affected...

  12. Real-time simulation of the nonlinear visco-elastic deformations of soft tissues.

    Science.gov (United States)

    Basafa, Ehsan; Farahmand, Farzam

    2011-05-01

    Mass-spring-damper (MSD) models are often used for real-time surgery simulation due to their fast response and fairly realistic deformation replication. An improved real time simulation model of soft tissue deformation due to a laparoscopic surgical indenter was developed and tested. The mechanical realization of conventional MSD models was improved using nonlinear springs and nodal dampers, while their high computational efficiency was maintained using an adapted implicit integration algorithm. New practical algorithms for model parameter tuning, collision detection, and simulation were incorporated. The model was able to replicate complex biological soft tissue mechanical properties under large deformations, i.e., the nonlinear and viscoelastic behaviors. The simulated response of the model after tuning of its parameters to the experimental data of a deer liver sample, closely tracked the reference data with high correlation and maximum relative differences of less than 5 and 10%, for the tuning and testing data sets respectively. Finally, implementation of the proposed model and algorithms in a graphical environment resulted in a real-time simulation with update rates of 150 Hz for interactive deformation and haptic manipulation, and 30 Hz for visual rendering. The proposed real time simulation model of soft tissue deformation due to a laparoscopic surgical indenter was efficient, realistic, and accurate in ex vivo testing. This model is a suitable candidate for testing in vivo during laparoscopic surgery.

  13. Fluorescence microscopy for the evaluation of elastic tissue patterns within fibrous proliferations of the skin on hematoxylin-eosin-stained slides.

    Science.gov (United States)

    Borucki, Robert; Perry, David M; Lopez-Garcia, Dan R; Kazlouskaya, Viktoryia; Elston, Dirk M

    2018-01-05

    Diagnosis of fibrous tumors can be challenging and expensive due to the use of special stains. Determine the usefulness of fluorescence microscopy in the evaluation of elastic pattern on H&E stained slides. A total of 228 slides were evaluated by fluorescence microscopy for elastic tissue patterns and sensitivity and specificity determined for relevant comparisons. Fluorescence microscopy was found to be useful especially in the case of distinguishing dermatofibroma (DF) vs dermatofibrosarcoma protuberans (DFSP) and also dermatomyofibroma (DMF) vs other fibrous tumors. In some cases, excessive background staining made it difficult to interpret. Evaluation of elastic tissue patterns by fluorescence microscopy in fibrous tumors is a cheap and efficient means to further delineate these often challenging tumors. Copyright © 2018. Published by Elsevier Inc.

  14. Modeling material-degradation-induced elastic property of tissue engineering scaffolds.

    Science.gov (United States)

    Bawolin, N K; Li, M G; Chen, X B; Zhang, W J

    2010-11-01

    The mechanical properties of tissue engineering scaffolds play a critical role in the success of repairing damaged tissues/organs. Determining the mechanical properties has proven to be a challenging task as these properties are not constant but depend upon time as the scaffold degrades. In this study, the modeling of the time-dependent mechanical properties of a scaffold is performed based on the concept of finite element model updating. This modeling approach contains three steps: (1) development of a finite element model for the effective mechanical properties of the scaffold, (2) parametrizing the finite element model by selecting parameters associated with the scaffold microstructure and/or material properties, which vary with scaffold degradation, and (3) identifying selected parameters as functions of time based on measurements from the tests on the scaffold mechanical properties as they degrade. To validate the developed model, scaffolds were made from the biocompatible polymer polycaprolactone (PCL) mixed with hydroxylapatite (HA) nanoparticles and their mechanical properties were examined in terms of the Young modulus. Based on the bulk degradation exhibited by the PCL/HA scaffold, the molecular weight was selected for model updating. With the identified molecular weight, the finite element model developed was effective for predicting the time-dependent mechanical properties of PCL/HA scaffolds during degradation.

  15. Dentoskeletal and Soft Tissue Effects in the Treatment of Class II Malocclusion with Klammt's Elastic Open Activator.

    Science.gov (United States)

    Inamassu-Lemes, Sheila Marques; Fuziy, Acácio; Costa, André Luiz Ferreira; Carvalho, Paulo Eduardo Guedes; Nahás-Scocate, Ana Carla Raphaelli

    2016-01-01

    The purpose of this study was to evaluate the dentoskeletal and soft tissue effects resulting from treatment with Klammt's elastic open activator (EOA) functional orthopedic appliance in patients with Class II malocclusion characterized by mandibular deficiency. Teleradiographs were evaluated in the lateral aspect of the initial (T1) and final (T2) orthopedic phases for 16 patients with Class II, Division 1 malocclusion. The age range was from 9 to 11.2 years, with a mean age of 9.9 years. The cephalometric points were demarcated, and cephalometric measurements were obtained by the same investigator to avoid interobserver variability. The EOA promoted increased lower anterior facial height (LAFH), increased effective mandibular length, clockwise rotation of the mandible, retrusion and verticalization of the upper incisors, proclination and protrusion of the lower incisors, extrusion of the upper molars, mesial movement of the lower molars and anterior projection of the lower lip. Skeletal changes characterized by an increase in mandibular length and dentoalveolar changes with an emphasis on the verticalization and retrusion of the upper incisors, proclination of the lower incisors and mesial positioning of the lower molars were key to improving the occlusal relationship and esthetic facial factors. The EOA is well indicated in patients with Class II malocclusion due to mandibular deficiency with increased overbite, proclined upper incisors and verticalized lower incisors.

  16. Semianalytical Solution for the Deformation of an Elastic Layer under an Axisymmetrically Distributed Power-Form Load: Application to Fluid-Jet-Induced Indentation of Biological Soft Tissues.

    Science.gov (United States)

    Lu, Minhua; Huang, Shuai; Yang, Xianglong; Yang, Lei; Mao, Rui

    2017-01-01

    Fluid-jet-based indentation is used as a noncontact excitation technique by systems measuring the mechanical properties of soft tissues. However, the application of these devices has been hindered by the lack of theoretical solutions. This study developed a mathematical model for testing the indentation induced by a fluid jet and determined a semianalytical solution. The soft tissue was modeled as an elastic layer bonded to a rigid base. The pressure of the fluid jet impinging on the soft tissue was assumed to have a power-form function. The semianalytical solution was verified in detail using finite-element modeling, with excellent agreement being achieved. The effects of several parameters on the solution behaviors are reported, and a method for applying the solution to determine the mechanical properties of soft tissues is suggested.

  17. A new nonlinear parameter in the developed strain-to-applied strain of the soft tissues and its application in ultrasound elasticity imaging.

    Science.gov (United States)

    Xu, Jingping; Tripathy, Sakya; Rubin, Jonathan M; Stidham, Ryan W; Johnson, Laura A; Higgins, Peter D R; Kim, Kang

    2012-03-01

    Strain developed under quasi-static deformation has been mostly used in ultrasound elasticity imaging (UEI) to determine the stiffness change of tissues. However, the strain measure in UEI is often less sensitive to a subtle change of stiffness. This is particularly true for Crohn's disease where we have applied strain imaging to the differentiation of acutely inflamed bowel from chronically fibrotic bowel. In this study, a new nonlinear elastic parameter of the soft tissues is proposed to overcome this limit. The purpose of this study is to evaluate the newly proposed method and demonstrate its feasibility in the UEI. A nonlinear characteristic of soft tissues over a relatively large dynamic range of strain was investigated. A simplified tissue model based on a finite element (FE) analysis was integrated with a laboratory developed ultrasound radio-frequency (RF) signal synthesis program. Two-dimensional speckle tracking was applied to this model to simulate the nonlinear behavior of the strain developed in a target inclusion over the applied average strain to the surrounding tissues. A nonlinear empirical equation was formulated and optimized to best match the developed strain-to-applied strain relation obtained from the FE simulation. The proposed nonlinear equation was applied to in vivo measurements and nonlinear parameters were further empirically optimized. For an animal model, acute and chronic inflammatory bowel disease was induced in Lewis rats with trinitrobenzene sulfonic acid (TNBS)-ethanol treatments. After UEI, histopathology and direct mechanical measurements were performed on the excised tissues. The extracted nonlinear parameter from the developed strain-to-applied strain relation differentiated the three different tissue types with 1.96 ± 0.12 for normal, 1.50 ± 0.09 for the acutely inflamed and 1.03 ± 0.08 for the chronically fibrotic tissue. T-tests determined that the nonlinear parameters between normal, acutely inflamed and fibrotic tissue

  18. Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics.

    Science.gov (United States)

    Majkut, Stephanie F; Discher, Dennis E

    2012-11-01

    In this review, we discuss recent studies on the mechanosensitive morphology and function of cardiomyocytes derived from embryos and neonates. For early cardiomyocytes cultured on substrates of various stiffnesses, contractile function as measured by force production, work output and calcium handling is optimized when the culture substrate stiffness mimics that of the tissue from which the cells were obtained. This optimal contractile function corresponds to changes in sarcomeric protein conformation and organization that promote contractile ability. In light of current models for myofibillogenesis, a recent mathematical model of striation and alignment on elastic substrates helps to illuminate how substrate stiffness modulates early myofibril formation and organization. During embryonic heart formation and maturation, cardiac tissue mechanics change dynamically. Experiments and models highlighted here have important implications for understanding cardiomyocyte differentiation and function in development and perhaps in regeneration processes.

  19. Bimodal spectroscopy in elastic scattering and spatially resolved auto-fluorescence: instrumentation, light-tissues interaction modeling and application to ex vivo and in vivo biological tissues characterization for cancers detection

    International Nuclear Information System (INIS)

    Pery, Emilie

    2007-01-01

    This research activity aims at developing and validating a multimodal spectroscopy method in elastic scattering and auto-fluorescence to characterize biological tissues in vitro and in vivo. It is articulated in four axes. At first, instrumentation is considered with the development, the engineering and the experimental characterization of a fibers bimodal, multi-points spectrometry system allowing the acquisition of spectra in vivo (variable distances, fast acquisition). Secondly, the optical properties of tissues are modelled with the development and the experimental validation on phantoms of a photons propagation simulation algorithm in turbid media and multi-fluorescent. Thirdly, an experimental study has been conducted ex vivo on fresh and cryo-preserved arterial rings. It confirms the complementarity of spectroscopic measurements in elastic scattering and auto-fluorescence, and validates the method of multi-modality spectroscopy and the simulation of photons propagation algorithm. Results have well proved a correlation between rheological and optical properties. Finally, one second experimental study in vivo related to a pre-clinical tumoral model of bladder has been carried out. It highlights a significant difference in diffuse reflectance and/or auto-fluorescence and/or intrinsic fluorescence between healthy, inflammatory and tumoral tissues, on the basis of specific wavelength. The results of not supervised classification show that the combination of various spectroscopic approaches increases the reliability of the diagnosis. (author) [fr

  20. Tissue Elasticity Bridges Cancer Stem Cells to the Tumor Microenvironment Through microRNAs: Implications for a “Watch-and-Wait” Approach to Cancer

    Science.gov (United States)

    Li, Shengwen Calvin; Vu, Long T.; Luo, Jane Jianying; Zhong, Jiang F.; Li, Zhongjun; Dethlefs, Brent A; Loudon, William G.; Kabeer, Mustafa H.

    2017-01-01

    Targeting the tumor microenvironment (TME) through which cancer stem cells (CSCs) crosstalk for cancer initiation and progression, may open up new treatments different from those centered on the original hallmarks of cancer genetics thereby implying a new approach for suppression of TME-driven activation of CSCs. Cancer is dynamic, heterogeneous, evolving with the TME and can be influenced by tissue-specific elasticity. One of the mediators and modulators of the crosstalk between CSCs and mechanical forces is miRNA, which can be developmentally regulated, in a tissue- and cell-specific manner. Here, based on our previous data, we provide a framework through which such gene expression changes in response to external mechanical forces can be understood during cancer progression. Recognizing the ways mechanical forces regulate and affect intracellular signals with applications in cancer stem cell biology. Such TME-targeted pathways shed new light on strategies for attacking cancer stem cells with fewer side effects than traditional gene-based treatments for cancer, requiring a “watch-and-wait” approach. We attempt to address both normal brain microenvironment and tumor microenvironment as both works together, intertwining in pathology and physiology – a balance that needs to be maintained for the “watch-and-wait” approach to cancer. Thus, this review connected the subjects of tissue elasticity, tumor microenvironment, epigenetic of miRNAs, and stem-cell biology that are very relevant in cancer research and therapy. It attempts to unify apparently separate entities in a complex biological web, network, and system in a realistic and practical manner, i.e., to bridge basic research with clinical application. PMID:28270089

  1. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid.

    Science.gov (United States)

    Sundaram, Hema; Voigts, Bob; Beer, Kenneth; Meland, Melissa

    2010-11-01

    Two types of soft tissue filler that are in common use are those formulated primarily with calcium hydroxylapatite (CaHA) and those with cross-linked hyaluronic acid (cross-linked HA). To provide physicians with a scientific rationale for determining which soft tissue fillers are most appropriate for volume replacement. Six cross-linked HA soft tissue fillers (Restylane and Perlane from Medicis, Scottsdale, AZ; Restylane SubQ from Q-Med, Uppsala, Sweden; and Juvéderm Ultra, Juvéderm Ultra Plus, and Juvéderm Voluma from Allergan, Pringy, France) and a soft tissue filler consisting of CaHA microspheres in a carrier gel containing carboxymethyl cellulose (Radiesse, BioForm Medical, Inc., San Mateo, CA). METHODS The viscosity and elasticity of each filler gel were quantified according to deformation oscillation measurements conducted using a Thermo Haake RS600 Rheometer (Newington, NH) using a plate and plate geometry with a 1.2-mm gap. All measurements were performed using a 35-mm titanium sensor at 30°C. Oscillation measurements were taken at 5 pascal tau (τ) over a frequency range of 0.1 to 10 Hz (interpolated at 0.7 Hz). Researchers chose the 0.7-Hz frequency because it elicited the most reproducible results and was considered physiologically relevant for stresses that are common to the skin. RESULTS The rheological measurements in this study support the concept that soft tissue fillers that are currently used can be divided into three groups. CONCLUSION Rheological evaluation enables the clinician to objectively classify soft tissue fillers, to select specific filler products based on scientific principles, and to reliably predict how these products will perform--lifting, supporting, and sculpting--after they are appropriately injected. © 2010 by the American Society for Dermatologic Surgery, Inc.

  2. Non-invasive characterization of polyurethane-based tissue constructs in a rat abdominal repair model using high frequency ultrasound elasticity imaging.

    Science.gov (United States)

    Yu, Jiao; Takanari, Keisuke; Hong, Yi; Lee, Kee-Won; Amoroso, Nicholas J; Wang, Yadong; Wagner, William R; Kim, Kang

    2013-04-01

    The evaluation of candidate materials and designs for soft tissue scaffolds would benefit from the ability to monitor the mechanical remodeling of the implant site without the need for periodic animal sacrifice and explant analysis. Toward this end, the ability of non-invasive ultrasound elasticity imaging (UEI) to assess temporal mechanical property changes in three different types of porous, biodegradable polyurethane scaffolds was evaluated in a rat abdominal wall repair model. The polymers utilized were salt-leached scaffolds of poly(carbonate urethane) urea, poly(ester urethane) urea and poly(ether ester urethane) urea at 85% porosity. A total of 60 scaffolds (20 each type) were implanted in a full thickness muscle wall replacement in the abdomens of 30 rats. The constructs were ultrasonically scanned every 2 weeks and harvested at weeks 4, 8 and 12 for compression testing or histological analysis. UEI demonstrated different temporal stiffness trends among the different scaffold types, while the stiffness of the surrounding native tissue remained unchanged. The changes in average normalized strains developed in the constructs from UEI compared well with the changes of mean compliance from compression tests and histology. The average normalized strains and the compliance for the same sample exhibited a strong linear relationship. The ability of UEI to identify herniation and to characterize the distribution of local tissue in-growth with high resolution was also investigated. In summary, the reported data indicate that UEI may allow tissue engineers to sequentially evaluate the progress of tissue construct mechanical behavior in vivo and in some cases may reduce the need for interim time point animal sacrifice. Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Tissue elasticity displayed by elastography and its correlation with the characteristics of collagen type I and type III in prostatic stroma

    Directory of Open Access Journals (Sweden)

    Jie Tang

    2014-04-01

    Full Text Available We investigated the prostate elasticity displayed by elastography and its correlation with the content and distribution of collagen type I (Col1 and type III (Col3. A total of 62 patients underwent transrectal real-time tissue elastography (TRTE examinations. Targeted biopsies were performed after 12-core systematic biopsy. The tissues corresponding to the elastograms were stained with picric acid-sirius red. The distribution of Col1 and type Col3 was observed, and the collagen volume fraction (CVF of these two types of collagen fibers was calculated. The CVFs of Col1 in the stiff and soft groups were 0.05 ± 0.02 and 0.02 ± 0.01 (P = 0.002, respectively. The CVFs of Col3 in the stiff and soft groups were 0.05 ± 0.04 and 0.07 ± 0.03 (P = 0.13, respectively. The circular analysis results showed that collagen fibers were disorganized both in the soft and stiff groups. Col1 and Col3 were mainly cross-linked, and some parallelization was observed in the sections. The distributions of Col1 and Col3 were different between the stiff and soft groups (P = 0.03. In conclusion, the texture of the prostate is due to the content of Col1 and its relative correlation with Col3.

  4. Tissue elasticity displayed by elastography and its correlation with the characteristics of collagen type I and type III in prostatic stroma.

    Science.gov (United States)

    Tang, Jie; Zhang, Yan; Zhang, Ming-Bo; Li, Yan-Mi; Fei, Xiang; Song, Zhi-Gang

    2014-01-01

    We investigated the prostate elasticity displayed by elastography and its correlation with the content and distribution of collagen type I (Col1) and type III (Col3). A total of 62 patients underwent transrectal real-time tissue elastography (TRTE) examinations. Targeted biopsies were performed after 12-core systematic biopsy. The tissues corresponding to the elastograms were stained with picric acid-sirius red. The distribution of Col1 and type Col3 was observed, and the collagen volume fraction (CVF) of these two types of collagen fibers was calculated. The CVFs of Col1 in the stiff and soft groups were 0.05 ± 0.02 and 0.02 ± 0.01 (P = 0.002), respectively. The CVFs of Col3 in the stiff and soft groups were 0.05 ± 0.04 and 0.07 ± 0.03 (P = 0.13), respectively. The circular analysis results showed that collagen fibers were disorganized both in the soft and stiff groups. Col1 and Col3 were mainly cross-linked, and some parallelization was observed in the sections. The distributions of Col1 and Col3 were different between the stiff and soft groups (P = 0.03). In conclusion, the texture of the prostate is due to the content of Col1 and its relative correlation with Col3.

  5. Elastic properties

    International Nuclear Information System (INIS)

    Ledbetter, H.M.

    1983-01-01

    This chapter investigates the following five aspects of engineering-material solid-state elastic constants: general properties, interrelationships, relationships to other physical properties, changes during cooling from ambient to near-zero temperature, and near-zero-temperature behavior. Topics considered include compressibility, bulk modulus, Young's modulus, shear modulus, Poisson's ratio, Hooke's law, elastic-constant measuring methods, thermodynamic potentials, higher-order energy terms, specific heat, thermal expansivity, magnetic materials, structural phase transitions, polymers, composites, textured aggregates, and other-phenomena correlations. Some of the conclusions concerning polycrystalline elastic properties and their temperature dependence are: elastic constants are physical, not mechanical, properties which relate thermodynamically to other physical properties such as specific heat and thermal expansivity; elastic constants at low temperatures are nearly temperature independent, as required by the third law of thermodynamics; and elastic constants can be used to study directional properties of materials, such as textured aggregates and composites

  6. Tissue

    Directory of Open Access Journals (Sweden)

    David Morrissey

    2012-01-01

    Full Text Available Purpose. In vivo gene therapy directed at tissues of mesenchymal origin could potentially augment healing. We aimed to assess the duration and magnitude of transene expression in vivo in mice and ex vivo in human tissues. Methods. Using bioluminescence imaging, plasmid and adenoviral vector-based transgene expression in murine quadriceps in vivo was examined. Temporal control was assessed using a doxycycline-inducible system. An ex vivo model was developed and optimised using murine tissue, and applied in ex vivo human tissue. Results. In vivo plasmid-based transgene expression did not silence in murine muscle, unlike in liver. Although maximum luciferase expression was higher in muscle with adenoviral delivery compared with plasmid, expression reduced over time. The inducible promoter cassette successfully regulated gene expression with maximum levels a factor of 11 greater than baseline. Expression was re-induced to a similar level on a temporal basis. Luciferase expression was readily detected ex vivo in human muscle and tendon. Conclusions. Plasmid constructs resulted in long-term in vivo gene expression in skeletal muscle, in a controllable fashion utilising an inducible promoter in combination with oral agents. Successful plasmid gene transfection in human ex vivo mesenchymal tissue was demonstrated for the first time.

  7. Elastic Beanstalk

    CERN Document Server

    Vliet, Jurg; Wel, Steven; Dowd, Dara

    2011-01-01

    While it's always been possible to run Java applications on Amazon EC2, Amazon's Elastic Beanstalk makes the process easier-especially if you understand how it works beneath the surface. This concise, hands-on book not only walks you through Beanstalk for deploying and managing web applications in the cloud, you'll also learn how to use this AWS tool in other phases of development. Ideal if you're a developer familiar with Java applications or AWS, Elastic Beanstalk provides step-by-step instructions and numerous code samples for building cloud applications on Beanstalk that can handle lots

  8. TU-F-CAMPUS-J-03: Elasticity Functions Based On 4DCT Images to Predict Tumor and Normal Tissue Response to Radiation for Patients with Lung Cancers

    International Nuclear Information System (INIS)

    Zhong, H; Li, H; Gordon, J; Chetty, I

    2015-01-01

    Purpose: To investigate radiotherapy outcomes by incorporating 4DCT-based physiological and tumor elasticity functions for lung cancer patients. Methods: 4DCT images were acquired from 28 lung SBRT patients before radiation treatment. Deformable image registration (DIR) was performed from the end-inhale to the end-exhale using a B-Spline-based algorithm (Elastix, an open source software package). The resultant displacement vector fields (DVFs) were used to calculate a relative Jacobian function (RV) for each patient. The computed functions in the lung and tumor regions represent lung ventilation and tumor elasticity properties, respectively. The 28 patients were divided into two groups: 16 with two-year tumor local control (LC) and 12 with local failure (LF). The ventilation and elasticity related RV functions were calculated for each of these patients. Results: The LF patients have larger RV values than the LC patients. The mean RV value in the lung region was 1.15 (±0.67) for the LF patients, higher than 1.06 (±0.59) for the LC patients. In the tumor region, the elasticity-related RV values are 1.2 (±0.97) and 0.86 (±0.64) for the LF and LC patients, respectively. Among the 16 LC patients, 3 have the mean RV values greater than 1.0 in the tumors. These tumors were located near the diaphragm, where the displacements are relatively large.. RV functions calculated in the tumor were better correlated with treatment outcomes than those calculated in the lung. Conclusion: The ventilation and elasticity-related RV functions in the lung and tumor regions were calculated from 4DCT image and the resultant values showed differences between the LC and LF patients. Further investigation of the impact of the displacements on the computed RV is warranted. Results suggest that the RV images might be useful for evaluation of treatment outcome for lung cancer patients

  9. TU-F-CAMPUS-J-03: Elasticity Functions Based On 4DCT Images to Predict Tumor and Normal Tissue Response to Radiation for Patients with Lung Cancers

    Energy Technology Data Exchange (ETDEWEB)

    Zhong, H; Li, H; Gordon, J; Chetty, I [Henry Ford Health System, Detroit, MI (United States)

    2015-06-15

    Purpose: To investigate radiotherapy outcomes by incorporating 4DCT-based physiological and tumor elasticity functions for lung cancer patients. Methods: 4DCT images were acquired from 28 lung SBRT patients before radiation treatment. Deformable image registration (DIR) was performed from the end-inhale to the end-exhale using a B-Spline-based algorithm (Elastix, an open source software package). The resultant displacement vector fields (DVFs) were used to calculate a relative Jacobian function (RV) for each patient. The computed functions in the lung and tumor regions represent lung ventilation and tumor elasticity properties, respectively. The 28 patients were divided into two groups: 16 with two-year tumor local control (LC) and 12 with local failure (LF). The ventilation and elasticity related RV functions were calculated for each of these patients. Results: The LF patients have larger RV values than the LC patients. The mean RV value in the lung region was 1.15 (±0.67) for the LF patients, higher than 1.06 (±0.59) for the LC patients. In the tumor region, the elasticity-related RV values are 1.2 (±0.97) and 0.86 (±0.64) for the LF and LC patients, respectively. Among the 16 LC patients, 3 have the mean RV values greater than 1.0 in the tumors. These tumors were located near the diaphragm, where the displacements are relatively large.. RV functions calculated in the tumor were better correlated with treatment outcomes than those calculated in the lung. Conclusion: The ventilation and elasticity-related RV functions in the lung and tumor regions were calculated from 4DCT image and the resultant values showed differences between the LC and LF patients. Further investigation of the impact of the displacements on the computed RV is warranted. Results suggest that the RV images might be useful for evaluation of treatment outcome for lung cancer patients.

  10. Coupling multiscale X-ray physics and micromechanics for bone tissue composition and elasticity determination from micro-CT data, by example of femora from OVX and sham rats

    Science.gov (United States)

    Hasslinger, Patricia; Vass, Viktoria; Dejaco, Alexander; Blanchard, Romane; Örlygsson, Gissur; Gargiulo, Paolo; Hellmich, Christian

    2016-05-01

    Due to its high resolution, micro-CT (Computed Tomograph) scanning is the key to assess bone quality of sham and OVX (ovariectomized) rats. Combination of basic X-ray physics, such as the energy- and chemistry-dependence of attenuation coefficients, with results from ashing tests on rat bones, delivers mineral, organic, and water volume fractions within the voxels. Additional use of a microelastic model for bone provides voxel-specific elastic properties. The new method delivers realistic bone mass densities, and reveals that OVX protocols may indeed induce some bone mass loss, while the average composition of the bone tissue remains largely unaltered.

  11. Volume reconstruction of large tissue specimens from serial physical sections using confocal microscopy and correction of cutting deformations by elastic registration

    Czech Academy of Sciences Publication Activity Database

    Čapek, Martin; Brůža, Petr; Janáček, Jiří; Karen, Petr; Kubínová, Lucie; Vagnerová, R.

    2009-01-01

    Roč. 72, č. 2 (2009), s. 110-119 ISSN 1059-910X R&D Projects: GA AV ČR(CZ) IAA100110502; GA AV ČR(CZ) IAA500200510; GA ČR(CZ) GA102/08/0691; GA MŠk(CZ) LC06063 Institutional research plan: CEZ:AV0Z50110509 Keywords : 3D reconstruction * elastic registration * confocal microscopy Subject RIV: JD - Computer Applications, Robotics Impact factor: 1.850, year: 2009

  12. TU-F-BRF-02: MR-US Prostate Registration Using Patient-Specific Tissue Elasticity Property Prior for MR-Targeted, TRUS-Guided HDR Brachytherapy

    International Nuclear Information System (INIS)

    Yang, X; Rossi, P; Ogunleye, T; Jani, A; Curran, W; Liu, T

    2014-01-01

    Purpose: High-dose-rate (HDR) brachytherapy has become a popular treatment modality for prostate cancer. Conventional transrectal ultrasound (TRUS)-guided prostate HDR brachytherapy could benefit significantly from MR-targeted, TRUS-guided procedure where the tumor locations, acquired from the multiparametric MRI, are incorporated into the treatment planning. In order to enable this integration, we have developed a MR-TRUS registration with a patient-specific biomechanical elasticity prior. Methods: The proposed method used a biomechanical elasticity prior to guide the prostate volumetric B-spline deformation in the MRI and TRUS registration. The patient-specific biomechanical elasticity prior was generated using ultrasound elastography, where two 3D TRUS prostate images were acquired under different probe-induced pressures during the HDR procedure, which takes 2-4 minutes. These two 3D TRUS images were used to calculate the local displacement (elasticity map) of two prostate volumes. The B-spline transformation was calculated by minimizing the Euclidean distance between the normalized attribute vectors of the prostate surface landmarks on the MR and TRUS. This technique was evaluated through two studies: a prostate-phantom study and a pilot study with 5 patients undergoing prostate HDR treatment. The accuracy of our approach was assessed through the locations of several landmarks in the post-registration and TRUS images; our registration results were compared with the surface-based method. Results: For the phantom study, the mean landmark displacement of the proposed method was 1.29±0.11 mm. For the 5 patients, the mean landmark displacement of the surface-based method was 3.25±0.51 mm; our method, 1.71±0.25 mm. Therefore, our proposed method of prostate registration outperformed the surfaced-based registration significantly. Conclusion: We have developed a novel MR-TRUS prostate registration approach based on patient-specific biomechanical elasticity prior

  13. Elastic scattering

    International Nuclear Information System (INIS)

    Leader, Elliot

    1991-01-01

    With very few unexplained results to challenge conventional ideas, physicists have to look hard to search for gaps in understanding. An area of physics which offers a lot more than meets the eye is elastic and diffractive scattering where particles either 'bounce' off each other, emerging unscathed, or just graze past, emerging relatively unscathed. The 'Blois' workshops provide a regular focus for this unspectacular, but compelling physics, attracting highly motivated devotees

  14. Thermo-elastic optical coherence tomography

    NARCIS (Netherlands)

    Wang, Tianshi; Pfeiffer, Tom; Wu, Min; Wieser, Wolfgang; Amenta, Gaetano; Draxinger, Wolfgang; van der Steen, A.F.W.; Huber, Robert; Van Soest, Gijs

    2017-01-01

    The absorption of nanosecond laser pulses induces rapid thermo-elastic deformation in tissue. A sub-micrometer scale displacement occurs within a few microseconds after the pulse arrival. In this Letter, we investigate the laser-induced thermo-elastic deformation using a 1.5 MHz phase-sensitive

  15. Nonlinear Elasticity

    Science.gov (United States)

    Fu, Y. B.; Ogden, R. W.

    2001-05-01

    This collection of papers by leading researchers in the field of finite, nonlinear elasticity concerns itself with the behavior of objects that deform when external forces or temperature gradients are applied. This process is extremely important in many industrial settings, such as aerospace and rubber industries. This book covers the various aspects of the subject comprehensively with careful explanations of the basic theories and individual chapters each covering a different research direction. The authors discuss the use of symbolic manipulation software as well as computer algorithm issues. The emphasis is placed firmly on covering modern, recent developments, rather than the very theoretical approach often found. The book will be an excellent reference for both beginners and specialists in engineering, applied mathematics and physics.

  16. Computational Elastic Knots

    KAUST Repository

    Zhao, Xin

    2013-01-01

    Elastic rods have been studied intensively since the 18th century. Even now the theory of elastic rods is still developing and enjoying popularity in computer graphics and physical-based simulation. Elastic rods also draw attention from architects

  17. Computing dispersion curves of elastic/viscoelastic transversely-isotropic bone plates coupled with soft tissue and marrow using semi-analytical finite element (SAFE) method.

    Science.gov (United States)

    Nguyen, Vu-Hieu; Tran, Tho N H T; Sacchi, Mauricio D; Naili, Salah; Le, Lawrence H

    2017-08-01

    We present a semi-analytical finite element (SAFE) scheme for accurately computing the velocity dispersion and attenuation in a trilayered system consisting of a transversely-isotropic (TI) cortical bone plate sandwiched between the soft tissue and marrow layers. The soft tissue and marrow are mimicked by two fluid layers of finite thickness. A Kelvin-Voigt model accounts for the absorption of all three biological domains. The simulated dispersion curves are validated by the results from the commercial software DISPERSE and published literature. Finally, the algorithm is applied to a viscoelastic trilayered TI bone model to interpret the guided modes of an ex-vivo experimental data set from a bone phantom. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Computational Elastic Knots

    KAUST Repository

    Zhao, Xin

    2013-05-01

    Elastic rods have been studied intensively since the 18th century. Even now the theory of elastic rods is still developing and enjoying popularity in computer graphics and physical-based simulation. Elastic rods also draw attention from architects. Architectural structures, NODUS, were constructed by elastic rods as a new method of form-finding. We study discrete models of elastic rods and NODUS structures. We also develop computational tools to find the equilibria of elastic rods and the shape of NODUS. Applications of elastic rods in forming torus knot and closing Bishop frame are included in this thesis.

  19. Thermo-elastic optical coherence tomography.

    Science.gov (United States)

    Wang, Tianshi; Pfeiffer, Tom; Wu, Min; Wieser, Wolfgang; Amenta, Gaetano; Draxinger, Wolfgang; van der Steen, Antonius F W; Huber, Robert; Soest, Gijs van

    2017-09-01

    The absorption of nanosecond laser pulses induces rapid thermo-elastic deformation in tissue. A sub-micrometer scale displacement occurs within a few microseconds after the pulse arrival. In this Letter, we investigate the laser-induced thermo-elastic deformation using a 1.5 MHz phase-sensitive optical coherence tomography (OCT) system. A displacement image can be reconstructed, which enables a new modality of phase-sensitive OCT, called thermo-elastic OCT. An analysis of the results shows that the optical absorption is a dominating factor for the displacement. Thermo-elastic OCT is capable of visualizing inclusions that do not appear on the structural OCT image, providing additional tissue type information.

  20. Advances in biomimetic regeneration of elastic matrix structures

    Science.gov (United States)

    Sivaraman, Balakrishnan; Bashur, Chris A.

    2012-01-01

    Elastin is a vital component of the extracellular matrix, providing soft connective tissues with the property of elastic recoil following deformation and regulating the cellular response via biomechanical transduction to maintain tissue homeostasis. The limited ability of most adult cells to synthesize elastin precursors and assemble them into mature crosslinked structures has hindered the development of functional tissue-engineered constructs that exhibit the structure and biomechanics of normal native elastic tissues in the body. In diseased tissues, the chronic overexpression of proteolytic enzymes can cause significant matrix degradation, to further limit the accumulation and quality (e.g., fiber formation) of newly deposited elastic matrix. This review provides an overview of the role and importance of elastin and elastic matrix in soft tissues, the challenges to elastic matrix generation in vitro and to regenerative elastic matrix repair in vivo, current biomolecular strategies to enhance elastin deposition and matrix assembly, and the need to concurrently inhibit proteolytic matrix disruption for improving the quantity and quality of elastogenesis. The review further presents biomaterial-based options using scaffolds and nanocarriers for spatio-temporal control over the presentation and release of these biomolecules, to enable biomimetic assembly of clinically relevant native elastic matrix-like superstructures. Finally, this review provides an overview of recent advances and prospects for the application of these strategies to regenerating tissue-type specific elastic matrix structures and superstructures. PMID:23355960

  1. A biomaterial composed of collagen and solubilized elastin enhances angiogenesis and elastic fiber formation without calcification.

    NARCIS (Netherlands)

    Daamen, W.F.; Nillesen, S.T.M.; Wismans, P.G.P.; Reinhardt, D.; Hafmans, T.G.M.; Veerkamp, J.H.; Kuppevelt, A.H.M.S.M. van

    2008-01-01

    Elastin is the prime protein in elastic tissues that contributes to elasticity of, for example, lung, aorta, and skin. Upon injury, elastic fibers are not readily replaced, which hampers tissue regeneration. Incorporation of solubilized elastin (hydrolyzed insoluble elastin fibers or elastin

  2. Elastic scattering and quasi-elastic transfers

    International Nuclear Information System (INIS)

    Mermaz, M.C.

    1978-01-01

    Experiments are presented which it will be possible to carry out at GANIL on the elastic scattering of heavy ions: diffraction phenomena if the absorption is great, refraction phenomena if absorption is low. The determination of the optical parameters can be performed. The study of the quasi-elastic transfer reactions will make it possible to know the dynamics of the nuclear reactions, form exotic nuclei and study their energy excitation spectrum, and analyse the scattering and reaction cross sections [fr

  3. ElasticSearch cookbook

    CERN Document Server

    Paro, Alberto

    2013-01-01

    Written in an engaging, easy-to-follow style, the recipes will help you to extend the capabilities of ElasticSearch to manage your data effectively.If you are a developer who implements ElasticSearch in your web applications, manage data, or have decided to start using ElasticSearch, this book is ideal for you. This book assumes that you've got working knowledge of JSON and Java

  4. ElasticSearch cookbook

    CERN Document Server

    Paro, Alberto

    2015-01-01

    If you are a developer who implements ElasticSearch in your web applications and want to sharpen your understanding of the core elements and applications, this is the book for you. It is assumed that you've got working knowledge of JSON and, if you want to extend ElasticSearch, of Java and related technologies.

  5. Elasticity theory and applications

    CERN Document Server

    Saada, Adel S; Hartnett, James P; Hughes, William F

    2013-01-01

    Elasticity: Theory and Applications reviews the theory and applications of elasticity. The book is divided into three parts. The first part is concerned with the kinematics of continuous media; the second part focuses on the analysis of stress; and the third part considers the theory of elasticity and its applications to engineering problems. This book consists of 18 chapters; the first of which deals with the kinematics of continuous media. The basic definitions and the operations of matrix algebra are presented in the next chapter, followed by a discussion on the linear transformation of points. The study of finite and linear strains gradually introduces the reader to the tensor concept. Orthogonal curvilinear coordinates are examined in detail, along with the similarities between stress and strain. The chapters that follow cover torsion; the three-dimensional theory of linear elasticity and the requirements for the solution of elasticity problems; the method of potentials; and topics related to cylinders, ...

  6. Statistical mechanics of elasticity

    CERN Document Server

    Weiner, JH

    2012-01-01

    Advanced, self-contained treatment illustrates general principles and elastic behavior of solids. Topics include thermoelastic behavior of crystalline and polymeric solids, interatomic force laws, behavior of solids, and thermally activated processes. 1983 edition.

  7. Elasticity of energy consumption

    International Nuclear Information System (INIS)

    Stam, M.

    2004-01-01

    Insight is given into the price elasticities of several energy carriers. Next, attention is paid to the impact of the discussion on changes of the Regulating Energy Levy (REB, abbreviated in Dutch) in the Netherlands [nl

  8. Mastering ElasticSearch

    CERN Document Server

    Kuc, Rafal

    2013-01-01

    A practical tutorial that covers the difficult design, implementation, and management of search solutions.Mastering ElasticSearch is aimed at to intermediate users who want to extend their knowledge about ElasticSearch. The topics that are described in the book are detailed, but we assume that you already know the basics, like the query DSL or data indexing. Advanced users will also find this book useful, as the examples are getting deep into the internals where it is needed.

  9. Nonlinear elastic waves in materials

    CERN Document Server

    Rushchitsky, Jeremiah J

    2014-01-01

    The main goal of the book is a coherent treatment of the theory of propagation in materials of nonlinearly elastic waves of displacements, which corresponds to one modern line of development of the nonlinear theory of elastic waves. The book is divided on five basic parts: the necessary information on waves and materials; the necessary information on nonlinear theory of elasticity and elastic materials; analysis of one-dimensional nonlinear elastic waves of displacement – longitudinal, vertically and horizontally polarized transverse plane nonlinear elastic waves of displacement; analysis of one-dimensional nonlinear elastic waves of displacement – cylindrical and torsional nonlinear elastic waves of displacement; analysis of two-dimensional nonlinear elastic waves of displacement – Rayleigh and Love nonlinear elastic surface waves. The book is addressed first of all to people working in solid mechanics – from the students at an advanced undergraduate and graduate level to the scientists, professional...

  10. WE-E-9A-01: Ultrasound Elasticity

    Energy Technology Data Exchange (ETDEWEB)

    Emelianov, S [University of Texas at Austin, Austin, TX (United States); Hall, T [University of WI-Madison, Madison, WI (United States); Bouchard, R [UT MD Anderson Cancer Center and UTHSC at Houston Graduate School of Biomed, Houston, TX (United States)

    2014-06-15

    Principles and techniques of ultrasound-based elasticity imaging will be presented, including quasistatic strain imaging, shear wave elasticity imaging, and their implementations in available systems. Deeper exploration of quasistatic methods, including elastic relaxation, and their applications, advantages, artifacts and limitations will be discussed. Transient elastography based on progressive and standing shear waves will be explained in more depth, along with applications, advantages, artifacts and limitations, as will measurement of complex elastic moduli. Comparisons will be made between ultrasound radiation force techniques, MR elastography, and the simple A mode plus mechanical plunger technique. Progress in efforts, such as that by the Quantitative Imaging Biomarkers Alliance, to reduce the differences in the elastic modulus reported by different commercial systems will be explained. Dr. Hall is on an Advisory Board for Siemens Ultrasound and has a research collaboration with them, including joint funding by R01CA140271 for nonlinear elasticity imaging. Learning Objectives: Be reminded of the long history of palpation of tissue elasticity for critical medical diagnosis and the relatively recent advances to be able to image tissue strain in response to an applied force. Understand the differences between shear wave speed elasticity measurement and imaging and understand the factors affecting measurement and image frame repletion rates. Understand shear wave propagation effects that can affect measurements, such as essentially lack of propagation in fluids and boundary effects, so important in thin layers. Know characteristics of available elasticity imaging phantoms, their uses and limitations. Understand thermal and cavitational limitations affecting radiation force-based shear wave imaging. Have learning and references adequate to for you to use in teaching elasticity imaging to residents and technologists. Be able to explain how elasticity measurement

  11. WE-E-9A-01: Ultrasound Elasticity

    International Nuclear Information System (INIS)

    Emelianov, S; Hall, T; Bouchard, R

    2014-01-01

    Principles and techniques of ultrasound-based elasticity imaging will be presented, including quasistatic strain imaging, shear wave elasticity imaging, and their implementations in available systems. Deeper exploration of quasistatic methods, including elastic relaxation, and their applications, advantages, artifacts and limitations will be discussed. Transient elastography based on progressive and standing shear waves will be explained in more depth, along with applications, advantages, artifacts and limitations, as will measurement of complex elastic moduli. Comparisons will be made between ultrasound radiation force techniques, MR elastography, and the simple A mode plus mechanical plunger technique. Progress in efforts, such as that by the Quantitative Imaging Biomarkers Alliance, to reduce the differences in the elastic modulus reported by different commercial systems will be explained. Dr. Hall is on an Advisory Board for Siemens Ultrasound and has a research collaboration with them, including joint funding by R01CA140271 for nonlinear elasticity imaging. Learning Objectives: Be reminded of the long history of palpation of tissue elasticity for critical medical diagnosis and the relatively recent advances to be able to image tissue strain in response to an applied force. Understand the differences between shear wave speed elasticity measurement and imaging and understand the factors affecting measurement and image frame repletion rates. Understand shear wave propagation effects that can affect measurements, such as essentially lack of propagation in fluids and boundary effects, so important in thin layers. Know characteristics of available elasticity imaging phantoms, their uses and limitations. Understand thermal and cavitational limitations affecting radiation force-based shear wave imaging. Have learning and references adequate to for you to use in teaching elasticity imaging to residents and technologists. Be able to explain how elasticity measurement

  12. Elastic anisotropy of crystals

    Directory of Open Access Journals (Sweden)

    Christopher M. Kube

    2016-09-01

    Full Text Available An anisotropy index seeks to quantify how directionally dependent the properties of a system are. In this article, the focus is on quantifying the elastic anisotropy of crystalline materials. Previous elastic anisotropy indices are reviewed and their shortcomings discussed. A new scalar log-Euclidean anisotropy measure AL is proposed, which overcomes these deficiencies. It is based on a distance measure in a log-Euclidean space applied to fourth-rank elastic tensors. AL is an absolute measure of anisotropy where the limiting case of perfect isotropy yields zero. It is a universal measure of anisotropy applicable to all crystalline materials. Specific examples of strong anisotropy are highlighted. A supplementary material provides an anisotropy table giving the values of AL for 2,176 crystallite compounds.

  13. Shells on elastic foundations

    International Nuclear Information System (INIS)

    Das, Y.C.; Kedia, K.K.

    1977-01-01

    No realistic analytical work in the area of Shells on Elastic Foundations has been reported in the literature. Various foundation models have been proposed by several authors. These models involve one or more than one parameters to characterise the foundation medium. Some of these models cannot be used to derive the basic equations governing the behaviour of shells on elastic foundations. In the present work, starting from an elastic continuum hypothesis, a mathematical model for foundation has been derived in curvilinear orthogonal coordinates by the help of principle of virtual displacements, treating one of the virtual displacements as known to satisfy certain given conditions at its edge surfaces. In this model, several foundation parameters can be considered and it can also be used for layered medium of both finite and infinite thickness. (Auth.)

  14. Anisotropic elastic plates

    CERN Document Server

    Hwu, Chyanbin

    2010-01-01

    As structural elements, anisotropic elastic plates find wide applications in modern technology. The plates here are considered to be subjected to not only in plane load but also transverse load. In other words, both plane and plate bending problems as well as the stretching-bending coupling problems are all explained in this book. In addition to the introduction of the theory of anisotropic elasticity, several important subjects have are discussed in this book such as interfaces, cracks, holes, inclusions, contact problems, piezoelectric materials, thermoelastic problems and boundary element a

  15. Hybrid elastic solids

    KAUST Repository

    Lai, Yun

    2011-06-26

    Metamaterials can exhibit electromagnetic and elastic characteristics beyond those found in nature. In this work, we present a design of elastic metamaterial that exhibits multiple resonances in its building blocks. Band structure calculations show two negative dispersion bands, of which one supports only compressional waves and thereby blurs the distinction between a fluid and a solid over a finite frequency regime, whereas the other displays super anisotropy-in which compressional waves and shear waves can propagate only along different directions. Such unusual characteristics, well explained by the effective medium theory, have no comparable analogue in conventional solids and may lead to novel applications. © 2011 Macmillan Publishers Limited. All rights reserved.

  16. Hybrid elastic solids

    KAUST Repository

    Lai, Yun; Wu, Ying; Sheng, Ping; Zhang, Zhaoqing

    2011-01-01

    Metamaterials can exhibit electromagnetic and elastic characteristics beyond those found in nature. In this work, we present a design of elastic metamaterial that exhibits multiple resonances in its building blocks. Band structure calculations show two negative dispersion bands, of which one supports only compressional waves and thereby blurs the distinction between a fluid and a solid over a finite frequency regime, whereas the other displays super anisotropy-in which compressional waves and shear waves can propagate only along different directions. Such unusual characteristics, well explained by the effective medium theory, have no comparable analogue in conventional solids and may lead to novel applications. © 2011 Macmillan Publishers Limited. All rights reserved.

  17. The law of elasticity

    Directory of Open Access Journals (Sweden)

    Sergio Cesare Masin

    2010-01-01

    Full Text Available Participants estimated the imagined elongation of a spring while they were imagining that a load was stretching the spring. This elongation turned out to be a multiplicative function of spring length and load weight-a cognitive law analogous to Hooke¿s law of elasticity. Participants also estimated the total imagined elongation of springs joined either in series or in parallel. This total elongation was longer for serial than for parallel springs, and increased proportionally to the number of serial springs and inversely proportionally to the number of parallel springs. The results suggest that participants integrated load weight with imagined elasticity rather than with spring length.

  18. ElasticSearch server

    CERN Document Server

    Rogozinski, Marek

    2014-01-01

    This book is a detailed, practical, hands-on guide packed with real-life scenarios and examples which will show you how to implement an ElasticSearch search engine on your own websites.If you are a web developer or a user who wants to learn more about ElasticSearch, then this is the book for you. You do not need to know anything about ElastiSeach, Java, or Apache Lucene in order to use this book, though basic knowledge about databases and queries is required.

  19. Elastic plastic fracture mechanics

    International Nuclear Information System (INIS)

    Simpson, L.A.

    1978-07-01

    The application of linear elastic fracture mechanics (LEFM) to crack stability in brittle structures is now well understood and widely applied. However, in many structural materials, crack propagation is accompanied by considerable crack-tip plasticity which invalidates the use of LEFM. Thus, present day research in fracture mechanics is aimed at developing parameters for predicting crack propagation under elastic-plastic conditions. These include critical crack-opening-displacement methods, the J integral and R-curve techniques. This report provides an introduction to these concepts and gives some examples of their applications. (author)

  20. Orthodontic Elastic Embedded in Gingiva for 7 Years

    Directory of Open Access Journals (Sweden)

    Shruti Tandon

    2013-01-01

    Full Text Available Dental materials especially orthodontic elastics often get embedded in gingival tissues due to iatrogenic factors. If retained for a long time, inflammatory response starts as asymptomatic crestal bone loss and may progress to severe periodontal abscess. Unsupported orthodontic elastics used for diastema closure may result in exfoliation of teeth, while elastic separators may get embedded in interdental gingiva if banding is performed without removing it. These cases of negligence are detrimental for survival of affected teeth. This paper highlights a case of orthodontic elastic embedded in interproximal gingiva of a 23-year-old healthy female for 7 years after completion of fixed orthodontic treatment. Surprisingly, there was no clinical sign of inflammation around elastic band and it was removed easily without any local anaesthesia. However, mild crestal bone loss was observed on periapical radiograph. The gingiva healed completely after sub gingival debridement.

  1. Model-Based Reconstructive Elasticity Imaging Using Ultrasound

    Directory of Open Access Journals (Sweden)

    Salavat R. Aglyamov

    2007-01-01

    Full Text Available Elasticity imaging is a reconstructive imaging technique where tissue motion in response to mechanical excitation is measured using modern imaging systems, and the estimated displacements are then used to reconstruct the spatial distribution of Young's modulus. Here we present an ultrasound elasticity imaging method that utilizes the model-based technique for Young's modulus reconstruction. Based on the geometry of the imaged object, only one axial component of the strain tensor is used. The numerical implementation of the method is highly efficient because the reconstruction is based on an analytic solution of the forward elastic problem. The model-based approach is illustrated using two potential clinical applications: differentiation of liver hemangioma and staging of deep venous thrombosis. Overall, these studies demonstrate that model-based reconstructive elasticity imaging can be used in applications where the geometry of the object and the surrounding tissue is somewhat known and certain assumptions about the pathology can be made.

  2. Fracton-Elasticity Duality

    Science.gov (United States)

    Pretko, Michael; Radzihovsky, Leo

    2018-05-01

    Motivated by recent studies of fractons, we demonstrate that elasticity theory of a two-dimensional quantum crystal is dual to a fracton tensor gauge theory, providing a concrete manifestation of the fracton phenomenon in an ordinary solid. The topological defects of elasticity theory map onto charges of the tensor gauge theory, with disclinations and dislocations corresponding to fractons and dipoles, respectively. The transverse and longitudinal phonons of crystals map onto the two gapless gauge modes of the gauge theory. The restricted dynamics of fractons matches with constraints on the mobility of lattice defects. The duality leads to numerous predictions for phases and phase transitions of the fracton system, such as the existence of gauge theory counterparts to the (commensurate) crystal, supersolid, hexatic, and isotropic fluid phases of elasticity theory. Extensions of this duality to generalized elasticity theories provide a route to the discovery of new fracton models. As a further consequence, the duality implies that fracton phases are relevant to the study of interacting topological crystalline insulators.

  3. The Law of Elasticity

    Science.gov (United States)

    Cocco, Alberto; Masin, Sergio Cesare

    2010-01-01

    Participants estimated the imagined elongation of a spring while they were imagining that a load was stretching the spring. This elongation turned out to be a multiplicative function of spring length and load weight--a cognitive law analogous to Hooke's law of elasticity. Participants also estimated the total imagined elongation of springs joined…

  4. Autonomic Vertical Elasticity of Docker Containers with ElasticDocker

    OpenAIRE

    Al-Dhuraibi , Yahya; Paraiso , Fawaz; Djarallah , Nabil; Merle , Philippe

    2017-01-01

    International audience; Elasticity is the key feature of cloud computing to scale computing resources according to application workloads timely. In the literature as well as in industrial products, much attention was given to the elasticity of virtual machines, but much less to the elasticity of containers. However, containers are the new trend for packaging and deploying microservices-based applications. Moreover, most of approaches focus on horizontal elasticity, fewer works address vertica...

  5. Non-linear elastic deformations

    CERN Document Server

    Ogden, R W

    1997-01-01

    Classic in the field covers application of theory of finite elasticity to solution of boundary-value problems, analysis of mechanical properties of solid materials capable of large elastic deformations. Problems. References.

  6. Designing interactively with elastic splines

    DEFF Research Database (Denmark)

    Brander, David; Bærentzen, Jakob Andreas; Fisker, Ann-Sofie

    2018-01-01

    We present an algorithm for designing interactively with C1 elastic splines. The idea is to design the elastic spline using a C1 cubic polynomial spline where each polynomial segment is so close to satisfying the Euler-Lagrange equation for elastic curves that the visual difference becomes neglig...... negligible. Using a database of cubic Bézier curves we are able to interactively modify the cubic spline such that it remains visually close to an elastic spline....

  7. Elastic fiber-mediated enthesis in the human middle ear.

    Science.gov (United States)

    Kawase, Tetsuaki; Shibata, Shunichi; Katori, Yukio; Ohtsuka, Aiji; Murakami, Gen; Fujimiya, Mineko

    2012-10-01

    Adaptation to constant vibration (acoustic oscillation) is likely to confer a specific morphology at the bone-tendon and bone-ligament interfaces at the ear ossicles, which therefore represent an exciting target of enthesis research. We histologically examined (i) the bone attachments of the tensor tympani and stapedius muscles and (ii) the annular ligament of the incudostapedial joint obtained from seven elderly donated cadavers. Notably, both aldehyde-fuchsin and elastic-Masson staining demonstrated that the major fibrous component of the entheses was not collagen fibers but mature elastic fibers. The positive controls for elastic fiber staining were the arterial wall elastic laminae included in the temporal bone materials. The elastic fibers were inserted deeply into the type II collagen-poor fibrocartilage covering the ear ossicles. The muscle tendons were composed of an outer thin layer of collagen fibers and an inner thick core of elastic fibers near the malleus or stapes. In the unique elastic fiber-mediated entheses, hyaluronan, versican and fibronectin were expressed strongly along the elastic fibers. The hyaluronan seemed to act as a friction-reducing lubricant for the elastic fibers. Aggrecan was labeled strongly in a disk- or plica-like fibrous mass on the inner side of the elastic fiber-rich ligament, possibly due to compression stress from the ligament. Tenascin-c was not evident in the entheses. The elastic fiber-mediated entheses appeared resistant to tissue destruction in an environment exposed to constant vibration. The morphology was unlikely to be the result of age-related degeneration. © 2012 The Authors Journal of Anatomy © 2012 Anatomical Society.

  8. NONLINEAR SPECTRAL IMAGING OF ELASTIC CARTILAGE IN RABBIT EARS

    Directory of Open Access Journals (Sweden)

    JING CHEN

    2013-07-01

    Full Text Available Elastic cartilage in the rabbit external ear is an important animal model with attractive potential value for researching the physiological and pathological states of cartilages especially during wound healing. In this work, nonlinear optical microscopy based on two-photon excited fluorescence and second harmonic generation were employed for imaging and quantifying the intact elastic cartilage. The morphology and distribution of main components in elastic cartilage including cartilage cells, collagen and elastic fibers were clearly observed from the high-resolution two-dimensional nonlinear optical images. The areas of cell nuclei, a parameter related to the pathological changes of normal or abnormal elastic cartilage, can be easily quantified. Moreover, the three-dimensional structure of chondrocytes and matrix were displayed by constructing three-dimensional image of cartilage tissue. At last, the emission spectra from cartilage were obtained and analyzed. We found that the different ratio of collagen over elastic fibers can be used to locate the observed position in the elastic cartilage. The redox ratio based on the ratio of nicotinamide adenine dinucleotide (NADH over flavin adenine dinucleotide (FAD fluorescence can also be calculated to analyze the metabolic state of chondrocytes in different regions. Our results demonstrated that this technique has the potential to provide more accurate and comprehensive information for the physiological states of elastic cartilage.

  9. Near-infrared spectroscopic tissue imaging for medical applications

    Science.gov (United States)

    Demos, Stavros [Livermore, CA; Staggs, Michael C [Tracy, CA

    2006-12-12

    Near infrared imaging using elastic light scattering and tissue autofluorescence are explored for medical applications. The approach involves imaging using cross-polarized elastic light scattering and tissue autofluorescence in the Near Infra-Red (NIR) coupled with image processing and inter-image operations to differentiate human tissue components.

  10. Approximation by planar elastic curves

    DEFF Research Database (Denmark)

    Brander, David; Gravesen, Jens; Nørbjerg, Toke Bjerge

    2016-01-01

    We give an algorithm for approximating a given plane curve segment by a planar elastic curve. The method depends on an analytic representation of the space of elastic curve segments, together with a geometric method for obtaining a good initial guess for the approximating curve. A gradient......-driven optimization is then used to find the approximating elastic curve....

  11. Elasticity in Elastics-An in-vitro study.

    Science.gov (United States)

    Kamisetty, Supradeep Kumar; Nimagadda, Chakrapani; Begam, Madhoom Ponnachi; Nalamotu, Raghuveer; Srivastav, Trilok; Gs, Shwetha

    2014-04-01

    Orthodontic tooth movement results from application of forces to teeth. Elastics in orthodontics have been used both intra-orally and extra- orally to a great effect. Their use, combined with good patient co-operation provides the clinician with the ability to correct both anteroposterior and vertical discrepancies. Force decay over a period of time is a major problem in the clinical usage of latex elastics and synthetic elastomers. This loss of force makes it difficult for the clinician to determine the actual force transmitted to the dentition. It's the intent of the clinician to maintain optimal force values over desired period of time. The majority of the orthodontic elastics on the market are latex elastics. Since the early 1990s, synthetic products have been offered in the market for latex-sensitive patients and are sold as nonlatex elastics. There is limited information on the risk that latex elastics may pose to patients. Some have estimated that 0.12-6% of the general population and 6.2% of dental professionals have hypersensitivity to latex protein. There are some reported cases of adverse reactions to latex in the orthodontic population but these are very limited to date. Although the risk is not yet clear, it would still be inadvisable to prescribe latex elastics to a patient with a known latex allergy. To compare the in-vitro performance of latex and non latex elastics. Samples of 0.25 inch, latex and non latex elastics (light, medium, heavy elastics) were obtained from three manufacturers (Forestadent, GAC, Glenroe) and a sample size of ten elastics per group was tested. The properties tested included cross sectional area, internal diameter, initial force generated by the elastics, breaking force and the force relaxation for the different types of elastics. Force relaxation testing involved stretching the elastics to three times marketed internal diameter (19.05 mm) and measuring force level at intervals over a period of 48 hours. The data were

  12. Xiphoid Process-Derived Chondrocytes: A Novel Cell Source for Elastic Cartilage Regeneration

    Science.gov (United States)

    Nam, Seungwoo; Cho, Wheemoon; Cho, Hyunji; Lee, Jungsun

    2014-01-01

    Reconstruction of elastic cartilage requires a source of chondrocytes that display a reliable differentiation tendency. Predetermined tissue progenitor cells are ideal candidates for meeting this need; however, it is difficult to obtain donor elastic cartilage tissue because most elastic cartilage serves important functions or forms external structures, making these tissues indispensable. We found vestigial cartilage tissue in xiphoid processes and characterized it as hyaline cartilage in the proximal region and elastic cartilage in the distal region. Xiphoid process-derived chondrocytes (XCs) showed superb in vitro expansion ability based on colony-forming unit fibroblast assays, cell yield, and cumulative cell growth. On induction of differentiation into mesenchymal lineages, XCs showed a strong tendency toward chondrogenic differentiation. An examination of the tissue-specific regeneration capacity of XCs in a subcutaneous-transplantation model and autologous chondrocyte implantation model confirmed reliable regeneration of elastic cartilage regardless of the implantation environment. On the basis of these observations, we conclude that xiphoid process cartilage, the only elastic cartilage tissue source that can be obtained without destroying external shape or function, is a source of elastic chondrocytes that show superb in vitro expansion and reliable differentiation capacity. These findings indicate that XCs could be a valuable cell source for reconstruction of elastic cartilage. PMID:25205841

  13. Introduction to linear elasticity

    CERN Document Server

    Gould, Phillip L

    2013-01-01

    Introduction to Linear Elasticity, 3rd Edition, provides an applications-oriented grounding in the tensor-based theory of elasticity for students in mechanical, civil, aeronautical, and biomedical engineering, as well as materials and earth science. The book is distinct from the traditional text aimed at graduate students in solid mechanics by introducing the subject at a level appropriate for advanced undergraduate and beginning graduate students. The author's presentation allows students to apply the basic notions of stress analysis and move on to advanced work in continuum mechanics, plasticity, plate and shell theory, composite materials, viscoelasticity and finite method analysis. This book also:  Emphasizes tensor-based approach while still distilling down to explicit notation Provides introduction to theory of plates, theory of shells, wave propagation, viscoelasticity and plasticity accessible to advanced undergraduate students Appropriate for courses following emerging trend of teaching solid mechan...

  14. Zirconium elasticity modules

    International Nuclear Information System (INIS)

    Vavra, G.

    1978-01-01

    Considered are the limit and the intermediate values of the Young modulus E, modulus of shear G and of linear modulus of compression K obtainable at various temperatures (4.2 to 1133 K) for single crystals of α-zirconium. Determined and presented are the corrected isotropic elasticity characteristics of E, G, K over the above range of temperatures of textured and non-textured α-Zr

  15. pp-elastic scattering

    Energy Technology Data Exchange (ETDEWEB)

    Aprile, E; Cantale, G; Degli-Agosti, S; Hausammann, R; Heer, E; Hess, R; Lechanoine-LeLuc, C; Leo, W; Morenzoni, S; Onel, Y [Geneva Univ. (Switzerland). Dept. de Physique Nucleaire et Corpusculaire

    1983-01-01

    The aim of the elastic pp experimental program at SIN was to measure enough spin dependent parameters in order to do a direct experimental reconstruction of the elastic scattering amplitudes at a few energies between 400 and 600 MeV and at several angles between 38/sup 0/ cm and 90/sup 0/ cm. This reconstruction was not possible until recently due to lack of experimental data. Information instead has come mainly from phase shift analysis (PSA). The only way to extract the elastic scattering amplitudes without any hypotheses except those of basic symmetries, is to measure a sufficient set of spin dependent parameters at a given angle and energy. With this in view, the authors have measured at 448, 494, 515, 536 and 579 MeV, the polarization, the spin correlation parameters Asub(00nn), Asub(00ss), Asub(00kk), Asub(00ks), the 2-spin parameters Dsub(n0n0), Ksub(n00n), Dsub(s'0s0), Dsub(s'0k0) and the 3-spin parameters Msub(s'0sn), Msub(s'0kn) between 34/sup 0/ cm and 118/sup 0/ cm. A few of these parameters have also been measured at 560 and 470 MeV and at a few energies below 448 MeV. The indices refer to the polarization orientation of the scattered, recoil, beam and target particle respectively.

  16. Elastic properties of Gum Metal

    International Nuclear Information System (INIS)

    Kuramoto, Shigeru; Furuta, Tadahiko; Hwang, Junghwan; Nishino, Kazuaki; Saito, Takashi

    2006-01-01

    In situ X-ray diffraction measurements under tensile loading and dynamic mechanical analysis were performed to investigate the mechanisms of elastic deformation in Gum Metal. Tensile stress-strain curves for Gum Metal indicate that cold working substantially decreases the elastic modulus while increasing the yield strength, thereby confirming nonlinearity in the elastic range. The gradient of each curve decreased continuously to about one-third its original value near the elastic limit. As a result of this decrease in elastic modulus and nonlinearity, elastic deformability reaches 2.5% after cold working. Superelasticity is attributed to stress-induced martensitic transformations, although the large elastic deformation in Gum Metal is not accompanied by a phase transformation

  17. Form finding in elastic gridshells

    Science.gov (United States)

    Baek, Changyeob; Sageman-Furnas, Andrew O.; Jawed, Mohammad K.; Reis, Pedro M.

    2018-01-01

    Elastic gridshells comprise an initially planar network of elastic rods that are actuated into a shell-like structure by loading their extremities. The resulting actuated form derives from the elastic buckling of the rods subjected to inextensibility. We study elastic gridshells with a focus on the rational design of the final shapes. Our precision desktop experiments exhibit complex geometries, even from seemingly simple initial configurations and actuation processes. The numerical simulations capture this nonintuitive behavior with excellent quantitative agreement, allowing for an exploration of parameter space that reveals multistable states. We then turn to the theory of smooth Chebyshev nets to address the inverse design of hemispherical elastic gridshells. The results suggest that rod inextensibility, not elastic response, dictates the zeroth-order shape of an actuated elastic gridshell. As it turns out, this is the shape of a common household strainer. Therefore, the geometry of Chebyshev nets can be further used to understand elastic gridshells. In particular, we introduce a way to quantify the intrinsic shape of the empty, but enclosed regions, which we then use to rationalize the nonlocal deformation of elastic gridshells to point loading. This justifies the observed difficulty in form finding. Nevertheless, we close with an exploration of concatenating multiple elastic gridshell building blocks.

  18. A new approach to ultrasonic elasticity imaging

    Science.gov (United States)

    Hoerig, Cameron; Ghaboussi, Jamshid; Fatemi, Mostafa; Insana, Michael F.

    2016-04-01

    Biomechanical properties of soft tissues can provide information regarding the local health status. Often the cells in pathological tissues can be found to form a stiff extracellular environment, which is a sensitive, early diagnostic indicator of disease. Quasi-static ultrasonic elasticity imaging provides a way to image the mechanical properties of tissues. Strain images provide a map of the relative tissue stiffness, but ambiguities and artifacts limit its diagnostic value. Accurately mapping intrinsic mechanical parameters of a region may increase diagnostic specificity. However, the inverse problem, whereby force and displacement estimates are used to estimate a constitutive matrix, is ill conditioned. Our method avoids many of the issues involved with solving the inverse problem, such as unknown boundary conditions and incomplete information about the stress field, by building an empirical model directly from measured data. Surface force and volumetric displacement data gathered during imaging are used in conjunction with the AutoProgressive method to teach artificial neural networks the stress-strain relationship of tissues. The Autoprogressive algorithm has been successfully used in many civil engineering applications and to estimate ocular pressure and corneal stiffness; here, we are expanding its use to any tissues imaged ultrasonically. We show that force-displacement data recorded with an ultrasound probe and displacements estimated at a few points in the imaged region can be used to estimate the full stress and strain vectors throughout an entire model while only assuming conservation laws. We will also demonstrate methods to parameterize the mechanical properties based on the stress-strain response of trained neural networks. This method is a fundamentally new approach to medical elasticity imaging that for the first time provides full stress and strain vectors from one set of observation data.

  19. Mathematical foundations of elasticity

    CERN Document Server

    Marsden, Jerrold E

    1994-01-01

    This advanced-level study approaches mathematical foundations of three-dimensional elasticity using modern differential geometry and functional analysis. It is directed to mathematicians, engineers and physicists who wish to see this classical subject in a modern setting with examples of newer mathematical contributions. Prerequisites include a solid background in advanced calculus and the basics of geometry and functional analysis.The first two chapters cover the background geometry ― developed as needed ― and use this discussion to obtain the basic results on kinematics and dynamics of con

  20. Elastic and viscoplastic properties

    International Nuclear Information System (INIS)

    Lebensohn, R.A.

    2015-01-01

    In this chapter, we review crystal elasticity and plasticity-based self-consistent theories and apply them to the determination of the effective response of polycrystalline aggregates. These mean-field formulations, which enable the prediction of the mechanical behaviour of polycrystalline aggregates based on the heterogeneous and/or directional properties of their constituent single crystal grains and phases, are ideal tools to establish relationships between microstructure and properties of these materials, ubiquitous among fuels and structural materials for nuclear systems. (author)

  1. Mathematical methods in elasticity imaging

    CERN Document Server

    Ammari, Habib; Garnier, Josselin; Kang, Hyeonbae; Lee, Hyundae; Wahab, Abdul

    2015-01-01

    This book is the first to comprehensively explore elasticity imaging and examines recent, important developments in asymptotic imaging, modeling, and analysis of deterministic and stochastic elastic wave propagation phenomena. It derives the best possible functional images for small inclusions and cracks within the context of stability and resolution, and introduces a topological derivative-based imaging framework for detecting elastic inclusions in the time-harmonic regime. For imaging extended elastic inclusions, accurate optimal control methodologies are designed and the effects of uncertainties of the geometric or physical parameters on stability and resolution properties are evaluated. In particular, the book shows how localized damage to a mechanical structure affects its dynamic characteristics, and how measured eigenparameters are linked to elastic inclusion or crack location, orientation, and size. Demonstrating a novel method for identifying, locating, and estimating inclusions and cracks in elastic...

  2. Elastic emission polishing

    Energy Technology Data Exchange (ETDEWEB)

    Loewenthal, M.; Loseke, K.; Dow, T.A.; Scattergood, R.O.

    1988-12-01

    Elastic emission polishing, also called elastic emission machining (EEM), is a process where a stream of abrasive slurry is used to remove material from a substrate and produce damage free surfaces with controlled surface form. It is a noncontacting method utilizing a thick elasto-hydrodynamic film formed between a soft rotating ball and the workpiece to control the flow of the abrasive. An apparatus was built in the Center, which consists of a stationary spindle, a two-axis table for the workpiece, and a pump to circulate the working fluid. The process is controlled by a programmable computer numerical controller (CNC), which presently can operate the spindle speed and movement of the workpiece in one axis only. This apparatus has been used to determine material removal rates on different material samples as a function of time, utilizing zirconium oxide (ZrO{sub 2}) particles suspended in distilled water as the working fluid. By continuing a study of removal rates the process should become predictable, and thus create a new, effective, yet simple tool for ultra-precision mechanical machining of surfaces.

  3. Heavy ion elastic scatterings

    International Nuclear Information System (INIS)

    Mermaz, M.C.

    1984-01-01

    Diffraction and refraction play an important role in particle elastic scattering. The optical model treats correctly and simultaneously both phenomena but without disentangling them. Semi-classical discussions in terms of trajectories emphasize the refractive aspect due to the real part of the optical potential. The separation due to to R.C. Fuller of the quantal cross section into two components coming from opposite side of the target nucleus allows to understand better the refractive phenomenon and the origin of the observed oscillations in the elastic scattering angular distributions. We shall see that the real part of the potential is responsible of a Coulomb and a nuclear rainbow which allows to determine better the nuclear potential in the interior region near the nuclear surface since the volume absorption eliminates any effect of the real part of the potential for the internal partial scattering waves. Resonance phenomena seen in heavy ion scattering will be discussed in terms of optical model potential and Regge pole analysis. Compound nucleus resonances or quasi-molecular states can be indeed the more correct and fundamental alternative

  4. Design guidance for elastic followup

    International Nuclear Information System (INIS)

    Naugle, F.V.

    1983-01-01

    The basic mechanism of elastic followup is discussed in relation to piping design. It is shown how mechanistic insight gained from solutions for a two-bar problem can be used to identify dominant design parameters and to determine appropriate modifications where elastic followup is a potential problem. It is generally recognized that quantitative criteria are needed for elastic followup in the creep range where badly unbalanced lines can pose potential problems. Approaches for criteria development are discussed

  5. Income Elasticity of Environmental Amenities

    OpenAIRE

    Daniel Miles; Andrés Pereyra; Máximo Rossi

    2000-01-01

    In this paper we are concerned with the estimation of income elasticities of environmental amenities. The novelty is the application of econometric methods that take into account the problem of measurement errors when estimating these elasticities, which are common in microeconomic data and are not usually considered in the applied literature related with this issue. Our aim is to discuss whether the measurement error has signi…cant e¤ects on the elasticities. Data from the Expenditure Budget...

  6. Are rapid changes in brain elasticity possible?

    Science.gov (United States)

    Parker, K. J.

    2017-09-01

    Elastography of the brain is a topic of clinical and preclinical research, motivated by the potential for viscoelastic measures of the brain to provide sensitive indicators of pathological processes, and to assist in early diagnosis. To date, studies of the normal brain and of those with confirmed neurological disorders have reported a wide range of shear stiffness and shear wave speeds, even within similar categories. A range of factors including the shear wave frequency, and the age of the individual are thought to have a possible influence. However, it may be that short term dynamics within the brain may have an influence on the measured stiffness. This hypothesis is addressed quantitatively using the framework of the microchannel flow model, which derives the tissue stiffness, complex modulus, and shear wave speed as a function of the vascular and fluid network in combination with the elastic matrix that comprise the brain. Transformation rules are applied so that any changes in the fluid channels or the elastic matrix can be mapped to changes in observed elastic properties on a macroscopic scale. The results are preliminary but demonstrate that measureable, time varying changes in brain stiffness are possible simply by accounting for vasodynamic or electrochemical changes in the state of any region of the brain. The value of this preliminary exploration is to identify possible mechanisms and order-of-magnitude changes that may be testable in vivo by specialized protocols.

  7. Questions about elastic waves

    CERN Document Server

    Engelbrecht, Jüri

    2015-01-01

    This book addresses the modelling of mechanical waves by asking the right questions about them and trying to find suitable answers. The questions follow the analytical sequence from elementary understandings to complicated cases, following a step-by-step path towards increased knowledge. The focus is on waves in elastic solids, although some examples also concern non-conservative cases for the sake of completeness. Special attention is paid to the understanding of the influence of microstructure, nonlinearity and internal variables in continua. With the help of many mathematical models for describing waves, physical phenomena concerning wave dispersion, nonlinear effects, emergence of solitary waves, scales and hierarchies of waves as well as the governing physical parameters are analysed. Also, the energy balance in waves and non-conservative models with energy influx are discussed. Finally, all answers are interwoven into the canvas of complexity.

  8. Nonlinear Elasticity of Doped Semiconductors

    Science.gov (United States)

    2017-02-01

    AFRL-RY-WP-TR-2016-0206 NONLINEAR ELASTICITY OF DOPED SEMICONDUCTORS Mark Dykman and Kirill Moskovtsev Michigan State University...2016 4. TITLE AND SUBTITLE NONLINEAR ELASTICITY OF DOPED SEMICONDUCTORS 5a. CONTRACT NUMBER FA8650-16-1-7600 5b. GRANT NUMBER 5c. PROGRAM...vibration amplitude. 15. SUBJECT TERMS semiconductors , microresonators, microelectromechanical 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF

  9. Elasticity theory of ultrathin nanofilms

    International Nuclear Information System (INIS)

    Li, Jiangang; Yun, Guohong; Narsu, B; Yao, Haiyan

    2015-01-01

    A self-consistent theoretical scheme for describing the elastic behavior of ultrathin nanofilms (UTNFs) was proposed. Taking into account the lower symmetry of an UTNF compared to its bulk counterpart, additional elastic and magnetoelastic parameters were introduced to model the elasticity rigorously. The applications of current theory to several elastic and magnetoelastic systems gave excellent agreement with experiments. More importantly, the surface elastic and magnetoelastic parameters used to fit the experimental results are physically reasonable and in close agreement with those obtained from experiment and simulation. This fact suggests that the additional elastic (magnetoelastic) constants due to symmetry breaking are of great importance in theoretical description of the mechanical properties of UTNFs. And we proved that the elasticity of UTNFs should be described by a three-dimensional model just including the intrinsic surface and bulk parameters, but not the effective surface parameters. It is believed that the theory reported here is a universal strategy for elasticity and magnetoelasticity of ultrathin films. (paper)

  10. Multi-model polynomial chaos surrogate dictionary for Bayesian inference in elasticity problems

    KAUST Repository

    Contreras, Andres A.; Le Maî tre, Olivier P.; Aquino, Wilkins; Knio, Omar

    2016-01-01

    of stiff inclusions embedded in a soft matrix, mimicking tumors in soft tissues. We rely on a polynomial chaos (PC) surrogate to accelerate the inference process. The PC surrogate predicts the dependence of the displacements field with the random elastic

  11. Cell Elasticity Determines Macrophage Function

    Science.gov (United States)

    Patel, Naimish R.; Bole, Medhavi; Chen, Cheng; Hardin, Charles C.; Kho, Alvin T.; Mih, Justin; Deng, Linhong; Butler, James; Tschumperlin, Daniel; Fredberg, Jeffrey J.; Krishnan, Ramaswamy; Koziel, Henry

    2012-01-01

    Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central mechanism that regulates macrophage function. Using macrophages of different origins and species, we report that macrophage elasticity is a major determinant of innate macrophage function. Macrophage elasticity is modulated not only by classical biologic activators such as LPS and IFN-γ, but to an equal extent by substrate rigidity and substrate stretch. Macrophage elasticity is dependent upon actin polymerization and small rhoGTPase activation, but functional effects of elasticity are not predicted by examination of gene expression profiles alone. Taken together, these data demonstrate an unanticipated role for cell elasticity as a common pathway by which mechanical and biologic factors determine macrophage function. PMID:23028423

  12. Cell elasticity determines macrophage function.

    Directory of Open Access Journals (Sweden)

    Naimish R Patel

    Full Text Available Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central mechanism that regulates macrophage function. Using macrophages of different origins and species, we report that macrophage elasticity is a major determinant of innate macrophage function. Macrophage elasticity is modulated not only by classical biologic activators such as LPS and IFN-γ, but to an equal extent by substrate rigidity and substrate stretch. Macrophage elasticity is dependent upon actin polymerization and small rhoGTPase activation, but functional effects of elasticity are not predicted by examination of gene expression profiles alone. Taken together, these data demonstrate an unanticipated role for cell elasticity as a common pathway by which mechanical and biologic factors determine macrophage function.

  13. Multipurpose hooks for elastic attachment

    Directory of Open Access Journals (Sweden)

    Siddharth Shashidhar Revankar

    2014-01-01

    Full Text Available As certain bracket systems do not include hooks on premolar brackets for elastic attachment, Kobayashi or custom made ligature hooks have proven as an alternative. However, these hooks tend to bend labially when used with heavy elastics and these elastics can even pop loose from the hooks on mouth opening. The following article describes an innovative multipurpose hook which is simple, stiff and inexpensive and can be used for engagement of class II elastics on premolars in case of missing molars as well as engagement of intermaxillary elastics for settling of occlusion in finishing stages. As the hooks can be prefabricated, this saves a lot of chair side time and is more practical for use in day-to-day orthodontic practice.

  14. Quasi-Elastic Light Scattering in Ophthalmology

    Science.gov (United States)

    Ansari, Rafat R.

    The eye is not just a "window to the soul"; it can also be a "window to the human body." The eye is built like a camera. Light which travels from the cornea to the retina traverses through tissues that are representative of nearly every tissue type and fluid type in the human body. Therefore, it is possible to diagnose ocular and systemic diseases through the eye. Quasi-elastic light scattering (QELS) also known as dynamic light scattering (DLS) is a laboratory technique routinely used in the characterization of macromolecular dispersions. QELS instrumentation has now become more compact, sensitive, flexible, and easy to use. These developments have made QELS/DLS an important tool in ophthalmic research where disease can be detected early and noninvasively before the clinical symptoms appear.

  15. Contour Propagation With Riemannian Elasticity Regularization

    DEFF Research Database (Denmark)

    Bjerre, Troels; Hansen, Mads Fogtmann; Sapru, W.

    2011-01-01

    Purpose/Objective(s): Adaptive techniques allow for correction of spatial changes during the time course of the fractionated radiotherapy. Spatial changes include tumor shrinkage and weight loss, causing tissue deformation and residual positional errors even after translational and rotational image...... the planning CT onto the rescans and correcting to reflect actual anatomical changes. For deformable registration, a free-form, multi-level, B-spline deformation model with Riemannian elasticity, penalizing non-rigid local deformations, and volumetric changes, was used. Regularization parameters was defined...... on the original delineation and tissue deformation in the time course between scans form a better starting point than rigid propagation. There was no significant difference of locally and globally defined regularization. The method used in the present study suggests that deformed contours need to be reviewed...

  16. Blocky inversion of multichannel elastic impedance for elastic parameters

    Science.gov (United States)

    Mozayan, Davoud Karami; Gholami, Ali; Siahkoohi, Hamid Reza

    2018-04-01

    Petrophysical description of reservoirs requires proper knowledge of elastic parameters like P- and S-wave velocities (Vp and Vs) and density (ρ), which can be retrieved from pre-stack seismic data using the concept of elastic impedance (EI). We propose an inversion algorithm which recovers elastic parameters from pre-stack seismic data in two sequential steps. In the first step, using the multichannel blind seismic inversion method (exploited recently for recovering acoustic impedance from post-stack seismic data), high-resolution blocky EI models are obtained directly from partial angle-stacks. Using an efficient total-variation (TV) regularization, each angle-stack is inverted independently in a multichannel form without prior knowledge of the corresponding wavelet. The second step involves inversion of the resulting EI models for elastic parameters. Mathematically, under some assumptions, the EI's are linearly described by the elastic parameters in the logarithm domain. Thus a linear weighted least squares inversion is employed to perform this step. Accuracy of the concept of elastic impedance in predicting reflection coefficients at low and high angles of incidence is compared with that of exact Zoeppritz elastic impedance and the role of low frequency content in the problem is discussed. The performance of the proposed inversion method is tested using synthetic 2D data sets obtained from the Marmousi model and also 2D field data sets. The results confirm the efficiency and accuracy of the proposed method for inversion of pre-stack seismic data.

  17. Elastic Anisotropy of Basalt

    Science.gov (United States)

    Becker, K.; Shapiro, S.; Stanchits, S.; Dresen, G.; Kaselow, A.; Vinciguerra, S.

    2005-12-01

    Elastic properties of rocks are sensitive to changes of the in-situ stress and damage state. In particular, seismic velocities are strongly affected by stress-induced formation and deformation of cracks or shear-enhanced pore collapse. The effect of stress on seismic velocities as a result of pore space deformation in isotropic rock at isostatic compression may be expressed by the equation: A+K*P-B*exp (-D*P) (1), where P=Pc-Pp is the effective pressure, the pure difference between confining pressure and pore pressure. The parameter A, K, B and D describe material constants determined using experimental data. The physical meaning of the parameters is given by Shapiro (2003, in Geophysics Vol.68(Nr.2)). Parameter D is related to the stress sensitivity of the rock. A similar relation was derived by Shapiro and Kaselow (2005, in Geophysics in press) for weak anisotropic rocks under arbitrary load. They describe the stress dependent anisotropy in terms of Thomson's (1986, in Geophysics, Vol. 51(Nr.10)) anisotropy parameters ɛ and γ as a function of stress in the case of an initially isotropic rock: ɛ ∝ E2-E3, γ ∝ E3-E2 (2) with Ei=exp (D*Pi). The exponential terms Ei are controlled by the effective stress components Pi. To test this relation, we have conducted a series of triaxial compression tests on dry samples of initially isotropic Etnean Basalt in a servo-controlled MTS loading frame equipped with a pressure cell. Confining pressure was 60, 40 and 20 MPa. Samples were 5 cm in diameter and 10 cm in length. Elastic anisotropy was induced by axial compression of the samples through opening and growth of microcracks predominantly oriented parallel to the sample axis. Ultrasonic P- and S- wave velocities were monitored parallel and normal to the sample axis by an array of 20 piezoceramic transducers glued to the surface. Preamplified full waveform signals were stored in two 12 channel transient recorders. According to equation 2 the anisotropy parameters are

  18. bessel functions for axisymmetric elasticity problems of the elastic

    African Journals Online (AJOL)

    HOD

    2, 3DEPARTMENT OF CIVIL ENGINEERING, UNIVERSITY OF NIGERIA, NSUKKA. ENUGU STATE. ... theory of elasticity and in the case of vertical applied loads, was first ... partial differential equations in bodies having cylindrical symmetry.

  19. Strain fluctuations and elastic constants

    Energy Technology Data Exchange (ETDEWEB)

    Parrinello, M.; Rahman, A.

    1982-03-01

    It is shown that the elastic strain fluctuations are a direct measure of elastic compliances in a general anisotropic medium; depending on the ensemble in which the fluctuation is measured either the isothermal or the adiabatic compliances are obtained. These fluctuations can now be calculated in a constant enthalpy and pressure, and hence, constant entropy, ensemble due to recent develpments in the molecular dynamics techniques. A calculation for a Ni single crystal under uniform uniaxial 100 tensile or compressive load is presented as an illustration of the relationships derived between various strain fluctuations and the elastic modulii. The Born stability criteria and the behavior of strain fluctuations are shown to be related.

  20. High energy elastic hadron scattering

    International Nuclear Information System (INIS)

    Fearnly, T.A.

    1986-04-01

    The paper deals with the WA7 experiment at the CERN super proton synchrotron (SPS). The elastic differential cross sections of pion-proton, kaon-proton, antiproton-proton, and proton-proton at lower SPS energies over a wide range of momentum transfer were measured. Some theoretical models in the light of the experimental results are reviewed, and a comprehensive impact parameter analysis of antiproton-proton elastic scattering over a wide energy range is presented. A nucleon valence core model for high energy proton-proton and antiproton-proton elastic scattering is described

  1. CONCERNING THE ELASTIC ORTHOTROPIC MODEL APPLIED TO WOOD ELASTIC PROPERTIES

    OpenAIRE

    Tadeu Mascia,Nilson

    2003-01-01

    Among the construction materials, wood reveals an orthotropic pattern, because of unique characteristics in its internal structure with three axes of wood biological directions (longitudinal, tangential and radial). elastic symmetry: longitudinal, tangential and radial, reveals an orthotropic pattern. The effect of grain angle orientation onin the elastic modulus constitutes the fundamental cause forof wood anisotropy. It is responsible for the greatest changes in the values of the constituti...

  2. Spectral dimension of elastic Sierpinski gaskets with general elastic forces

    International Nuclear Information System (INIS)

    Liu, S.H.; Liu, A.J.

    1985-01-01

    The spectral dimension is calculated for a Sierpinski gasket with the most general elastic restoring forces allowed by symmetry. The elastic forces consist of bond-stretching and angle-bending components. The spectral dimension is the same as that for the bond-stretching-force (central-force) model. This demonstrates that on the Sierpinski gasket the two types of forces belong to the same universality class

  3. Astronomical optics and elasticity theory

    CERN Document Server

    Lemaitre, Gerard Rene

    2008-01-01

    Astronomical Optics and Elasticity Theory provides a very thorough and comprehensive account of what is known in this field. After an extensive introduction to optics and elasticity, the book discusses variable curvature and multimode deformable mirrors, as well as, in depth, active optics, its theory and applications. Further, optical design utilizing the Schmidt concept and various types of Schmidt correctors, as well as the elasticity theory of thin plates and shells are elaborated upon. Several active optics methods are developed for obtaining aberration corrected diffraction gratings. Further, a weakly conical shell theory of elasticity is elaborated for the aspherization of grazing incidence telescope mirrors. The very didactic and fairly easy-to-read presentation of the topic will enable PhD students and young researchers to actively participate in challenging astronomical optics and instrumentation projects.

  4. Uniqueness theorems in linear elasticity

    CERN Document Server

    Knops, Robin John

    1971-01-01

    The classical result for uniqueness in elasticity theory is due to Kirchhoff. It states that the standard mixed boundary value problem for a homogeneous isotropic linear elastic material in equilibrium and occupying a bounded three-dimensional region of space possesses at most one solution in the classical sense, provided the Lame and shear moduli, A and J1 respectively, obey the inequalities (3 A + 2 J1) > 0 and J1>O. In linear elastodynamics the analogous result, due to Neumann, is that the initial-mixed boundary value problem possesses at most one solution provided the elastic moduli satisfy the same set of inequalities as in Kirchhoffs theorem. Most standard textbooks on the linear theory of elasticity mention only these two classical criteria for uniqueness and neglect altogether the abundant literature which has appeared since the original publications of Kirchhoff. To remedy this deficiency it seems appropriate to attempt a coherent description ofthe various contributions made to the study of uniquenes...

  5. Wrinkling of Pressurized Elastic Shells

    KAUST Repository

    Vella, Dominic; Ajdari, Amin; Vaziri, Ashkan; Boudaoud, Arezki

    2011-01-01

    We study the formation of localized structures formed by the point loading of an internally pressurized elastic shell. While unpressurized shells (such as a ping-pong ball) buckle into polygonal structures, we show that pressurized shells

  6. CONFERENCE: Elastic and diffractive scattering

    Energy Technology Data Exchange (ETDEWEB)

    White, Alan

    1989-09-15

    Elastic scattering, when particles appear to 'bounce' off each other, and the related phenomena of diffractive scattering are currently less fashionable than the study of hard scattering processes. However this could change rapidly if unexpected results from the UA4 experiment at the CERN Collider are confirmed and their implications tested. These questions were highlighted at the third 'Blois Workshop' on Elastic and Diffractive Scattering, held early in May on the Evanston campus of Northwestern University, near Chicago.

  7. A Labor Supply Elasticity Accord?

    OpenAIRE

    Lars Ljungqvist; Thomas J. Sargent

    2011-01-01

    A dispute about the size of the aggregate labor supply elasticity has been fortified by a contentious aggregation theory used by real business cycle theorists. The replacement of that aggregation theory with one more congenial to microeconomic observations opens possibilities for an accord about the aggregate labor supply elasticity. The new aggregation theory drops features to which empirical microeconomists objected and replaces them with life-cycle choices. Whether the new aggregation theo...

  8. Integrodifferential relations in linear elasticity

    CERN Document Server

    Kostin, Georgy V

    2012-01-01

    This work treats the elasticity of deformed bodies, including the resulting interior stresses and displacements.It also takes into account that some of constitutive relations can be considered in a weak form. To discuss this problem properly, the method of integrodifferential relations is used, and an advanced numerical technique for stress-strain analysis is presented and evaluated using various discretization techniques. The methods presented in this book are of importance for almost all elasticity problems in materials science and mechanical engineering.

  9. In Situ elastic property sensors

    International Nuclear Information System (INIS)

    Olness, D.; Hirschfeld, T.; Kishiyama, K.; Steinhaus, R.

    1987-01-01

    Elasticity is an important property of many materials. Loss of elasticity can have serious consequences, such as when a gasket deteriorates and permits leakage of an expensive or hazardous material, or when a damping system begins to go awry. Loss of elasticity can also provide information related to an ancillary activity such as degradation of electrical insulation, loss of plasticizer in a plastic, or changes in permeability of a thin film. In fact, the mechanical properties of most organic compounds are altered when the compound degrades. Thus, a sensor for the mechanical properties can be used to monitor associated characteristics as well. A piezoelectric material in contact with an elastomer forms an oscillating system that can provide real-time elasticity monitoring. This combination constitutes a forced harmonic oscillator with damping provided by the elastomer. A ceramic oscillator with a total volume of a few mm 3 was used as an elasticity sensor. It was placed in intimate contact with an elastomer and then monitored remotely with a simple oscillator circuit and standard frequency counting electronics. Resonant frequency shifts and changes in Q value were observed corresponding to changes in ambient temperature and/or changes in pressure applied to the sample. Elastomer samples pretreated with ozone (to simulate aging) showed changes in Q value and frequency response, even though there were no visible changes in the elastic samples

  10. Elastic fibers in human skin: quantitation of elastic fibers by computerized digital image analyses and determination of elastin by radioimmunoassay of desmosine.

    Science.gov (United States)

    Uitto, J; Paul, J L; Brockley, K; Pearce, R H; Clark, J G

    1983-10-01

    The elastic fibers in the skin and other organs can be affected in several disease processes. In this study, we have developed morphometric techniques that allow accurate quantitation of the elastic fibers in punch biopsy specimens of skin. In this procedure, the elastic fibers, visualized by elastin-specific stains, are examined through a camera unit attached to the microscope. The black and white images sensing various gray levels are then converted to binary images after selecting a threshold with an analog threshold selection device. The binary images are digitized and the data analyzed by a computer program designed to express the properties of the image, thus allowing determination of the volume fraction occupied by the elastic fibers. As an independent measure of the elastic fibers, alternate tissue sections were used for assay of desmosine, an elastin-specific cross-link compound, by a radioimmunoassay. The clinical applicability of the computerized morphometric analyses was tested by examining the elastic fibers in the skin of five patients with pseudoxanthoma elasticum or Buschke-Ollendorff syndrome. In the skin of 10 healthy control subjects, the elastic fibers occupied 2.1 +/- 1.1% (mean +/- SD) of the dermis. The volume fractions occupied by the elastic fibers in the lesions of pseudoxanthoma elasticum or Buschke-Ollendorff syndrome were increased as much as 6-fold, whereas the values in the unaffected areas of the skin in the same patients were within normal limits. A significant correlation between the volume fraction of elastic fibers, determined by computerized morphometric analyses, and the concentration of desmosine, quantitated by radioimmunoassay, was noted in the total material. These results demonstrate that computerized morphometric techniques are helpful in characterizing disease processes affecting skin. This methodology should also be applicable to other tissues that contain elastic fibers and that are affected in various heritable and

  11. Temperature dependence of elastic properties of paratellurite

    International Nuclear Information System (INIS)

    Silvestrova, I.M.; Pisarevskii, Y.V.; Senyushenkov, P.A.; Krupny, A.I.

    1987-01-01

    New data are presented on the temperature dependence of the elastic wave velocities, elastic stiffness constants, and thermal expansion of paratellurite. It is shown that the external pressure appreciably influences the elastic properties of TeO 2 , especially the temperature dependence of the elastic modulus connected with the crystal soft mode. (author)

  12. Ultrafast imaging of cell elasticity with optical microelastography.

    Science.gov (United States)

    Grasland-Mongrain, Pol; Zorgani, Ali; Nakagawa, Shoma; Bernard, Simon; Paim, Lia Gomes; Fitzharris, Greg; Catheline, Stefan; Cloutier, Guy

    2018-01-30

    Elasticity is a fundamental cellular property that is related to the anatomy, functionality, and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy, or Brillouin scattering are rather slow and do not always accurately represent cell elasticity. Here, we have developed an alternative technique by applying shear wave elastography to the micrometer scale. Elastic waves were mechanically induced in live mammalian oocytes using a vibrating micropipette. These audible frequency waves were observed optically at 200,000 frames per second and tracked with an optical flow algorithm. Whole-cell elasticity was then mapped using an elastography method inspired by the seismology field. Using this approach we show that the elasticity of mouse oocytes is decreased when the oocyte cytoskeleton is disrupted with cytochalasin B. The technique is fast (less than 1 ms for data acquisition), precise (spatial resolution of a few micrometers), able to map internal cell structures, and robust and thus represents a tractable option for interrogating biomechanical properties of diverse cell types. Copyright © 2018 the Author(s). Published by PNAS.

  13. The Morishima Gross elasticity of substitution

    OpenAIRE

    Blackorby, Charles; Primont, Daniel; Russell, R. Robert

    2007-01-01

    We show that the Hotelling-Lau elasticity of substitution, an extension of the Allen-Uzawa elasticity to allow for optimal output-quantity (or utility) responses to changes in factor prices, inherits all of the failings of the Allen-Uzawa elasticity identified by Blackorby and Russell [1989 AER]. An analogous extension of the Morishima elasticity of substitution to allow for output quantity changes preserves the salient properties of the original Hicksian notion of elasticity of substitution.

  14. Running With an Elastic Lower Limb Exoskeleton.

    Science.gov (United States)

    Cherry, Michael S; Kota, Sridhar; Young, Aaron; Ferris, Daniel P

    2016-06-01

    Although there have been many lower limb robotic exoskeletons that have been tested for human walking, few devices have been tested for assisting running. It is possible that a pseudo-passive elastic exoskeleton could benefit human running without the addition of electrical motors due to the spring-like behavior of the human leg. We developed an elastic lower limb exoskeleton that added stiffness in parallel with the entire lower limb. Six healthy, young subjects ran on a treadmill at 2.3 m/s with and without the exoskeleton. Although the exoskeleton was designed to provide ~50% of normal leg stiffness during running, it only provided 24% of leg stiffness during testing. The difference in added leg stiffness was primarily due to soft tissue compression and harness compliance decreasing exoskeleton displacement during stance. As a result, the exoskeleton only supported about 7% of the peak vertical ground reaction force. There was a significant increase in metabolic cost when running with the exoskeleton compared with running without the exoskeleton (ANOVA, P exoskeletons for human running are human-machine interface compliance and the extra lower limb inertia from the exoskeleton.

  15. Cusp-Shaped Elastic Creases and Furrows

    Science.gov (United States)

    Karpitschka, S.; Eggers, J.; Pandey, A.; Snoeijer, J. H.

    2017-11-01

    The surfaces of growing biological tissues, swelling gels, and compressed rubbers do not remain smooth, but frequently exhibit highly localized inward folds. We reveal the morphology of this surface folding in a novel experimental setup, which permits us to deform the surface of a soft gel in a controlled fashion. The interface first forms a sharp furrow, whose tip size decreases rapidly with deformation. Above a critical deformation, the furrow bifurcates to an inward folded crease of vanishing tip size. We show experimentally and numerically that both creases and furrows exhibit a universal cusp shape, whose width scales like y3 /2 at a distance y from the tip. We provide a similarity theory that captures the singular profiles before and after the self-folding bifurcation, and derive the length of the fold from finite deformation elasticity.

  16. Phason elasticity and surface roughening

    International Nuclear Information System (INIS)

    Tang Leihan; Jaric, M.V.

    1990-01-01

    The phason elasticity of two-dimensional (2D) equilibrium quasicrystals is discussed in analogy with surface roughening phenomena. Taking a Penrose tiling model as an example, we show that the phason elastic energy is linear in the phason strain at zero temperature (T = 0), but becomes quadratic at any T > 0 and sufficiently small strain. Heuristic and real-space renormalization group arguments are given for the thermal roughening of the hyper-surface which represents quasicrystal tiling. Monte Carlo method is applied to illustrate the logarithmically diverging phason fluctuations and power-law diffraction intensities at T > 0. For three-dimensional systems, we present arguments which suggest a finite temperature transition between two quasicrystal phases, characterized by linear and quadratic phason elastic energy, respectively. (author). 17 refs, 12 figs

  17. Appraisal of elastic follow up

    International Nuclear Information System (INIS)

    Roche, R.L.

    1981-08-01

    The aim of this paper is to provide indications to choose what fraction of a self limiting stress can be considered as secondary. At first, considerations are given to a simple structure which could be called ''creep relaxation tensile test''. A bar (with constant cross section) is loaded by an elastic spring in order to obtain a given elongation of the assembly. The stress evolution is studied. Then the creep damage is computed, and compared to the damage corresponding to the elastic computed stress. This comparison gives the fraction of the self limiting stress which must be considered as primary. This involve the structural parameter 0 which is the initial value of the ratio of elastic energy to dissipating power. Extension of the rule is made with the help of KACHANOV approximation. As a conclusion a procedure is described which determines what fraction of a self limiting stress must be considered as primary

  18. Investor response to consumer elasticity

    International Nuclear Information System (INIS)

    Grenaa Jensen, Stine; Meibom, Peter; Ravn, H.F.; Straarup, Sarah

    2004-01-01

    In the Nordic electricity system there is considerable uncertainty with respect to the long-term development in production capacity. The process towards liberalisation of the electricity sector started in a situation with a large reserve margin, but this margin is gradually vanishing. Since the potential investors in new production capacity are unaccustomed with investments under the new regime it is unknown if and when investments will take place. The electricity price is the key market signal to potential investors. The price is settled as a balance between supply and demand, and it is generally assumed that the demand side has an important role in this, and increasingly so. However, since consumers have not earlier had the incentive to respond to electricity prices, no reliable estimate of demand elasticity is known. The purpose of the present study is to analyse the role of electricity demand elasticity for investments in new electricity production capacity. Electricity price scenarios generated with a partial equilibrium model (Balmorel) are combined with a model of investment decisions. In this, various scenarios concerning the development in the demand elasticity are used. The simulated investment decisions are taken in a stochastic, dynamic setting, where a key point is the timing of the investment decision in relation to the gathering of new information relative to the stochastic elements. Based on this, the consequences of the development in consumer price elasticity for investments in a base load and a peak load plant are investigated. The main result of the analysis is that peak load investments can be made unprofitable by the development in consumer price elasticity, such that an investor will tend to wait with his peak load investment, until the development in consumer price elasticity has been revealed. (au)

  19. CONFERENCE: Elastic and diffractive scattering

    International Nuclear Information System (INIS)

    White, Alan

    1989-01-01

    Elastic scattering, when particles appear to 'bounce' off each other, and the related phenomena of diffractive scattering are currently less fashionable than the study of hard scattering processes. However this could change rapidly if unexpected results from the UA4 experiment at the CERN Collider are confirmed and their implications tested. These questions were highlighted at the third 'Blois Workshop' on Elastic and Diffractive Scattering, held early in May on the Evanston campus of Northwestern University, near Chicago

  20. Water hammer in elastic pipes

    International Nuclear Information System (INIS)

    Gale, J.; Tiselj, I.

    2002-01-01

    One dimensional two-fluid six-equation model of two-phase flow, that can be found in computer codes like RELAP5, TRAC, and CATHARE, was upgraded with additional terms, which enable modelling of the pressure waves in elastic pipes. It is known that pipe elasticity reduces the propagation velocity of the shock and other pressure waves in the piping systems. Equations that include the pipe elasticty terms are used in WAHA code, which is being developed within the WAHALoads project of 5't'h EU research program.(author)

  1. Three-Dimensional Computer-Assisted Two-Layer Elastic Models of the Face.

    Science.gov (United States)

    Ueda, Koichi; Shigemura, Yuka; Otsuki, Yuki; Fuse, Asuka; Mitsuno, Daisuke

    2017-11-01

    To make three-dimensional computer-assisted elastic models for the face, we decided on five requirements: (1) an elastic texture like skin and subcutaneous tissue; (2) the ability to take pen marking for incisions; (3) the ability to be cut with a surgical knife; (4) the ability to keep stitches in place for a long time; and (5) a layered structure. After testing many elastic solvents, we have made realistic three-dimensional computer-assisted two-layer elastic models of the face and cleft lip from the computed tomographic and magnetic resonance imaging stereolithographic data. The surface layer is made of polyurethane and the inner layer is silicone. Using this elastic model, we taught residents and young doctors how to make several typical local flaps and to perform cheiloplasty. They could experience realistic simulated surgery and understand three-dimensional movement of the flaps.

  2. Nonlinear theory of elastic shells

    International Nuclear Information System (INIS)

    Costa Junior, J.A.

    1979-08-01

    Nonlinear theory of elastic shells is developed which incorporates both geometric and physical nonlinearities and which does not make use of the well known Love-Kirchhoff hypothesis. The resulting equations are formulated in tensorial notation and are reduced to the ones of common use when simplifying assumptions encountered in the especific litterature are taken. (Author) [pt

  3. Heart transplantation and arterial elasticity

    Directory of Open Access Journals (Sweden)

    Colvin-Adams M

    2013-12-01

    Full Text Available Monica Colvin-Adams,1 Nonyelum Harcourt,1 Robert LeDuc,2 Ganesh Raveendran,1 Yassir Sonbol,3 Robert Wilson,1 Daniel Duprez11Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA; 2Division of Biostatistics University of Minnesota, Minneapolis, MN, USA; 3Cardiovascular Division, St Luke's Hospital System, Sugar Land, TX, USAObjective: Arterial elasticity is a functional biomarker that has predictive value for cardiovascular morbidity and mortality in nontransplant populations. There is little information regarding arterial elasticity in heart transplant recipients. This study aimed to characterize small (SAE and large (LAE artery elasticity in heart transplant recipients in comparison with an asymptomatic population free of overt cardiovascular disease. A second goal was to identify demographic and clinical factors associated with arterial elasticity in this unique population.Methods: Arterial pulse waveform was registered noninvasively at the radial artery in 71 heart transplant recipients between 2008 and 2010. SAEs and LAEs were derived from diastolic pulse contour analysis. Comparisons were made to a healthy cohort of 1,808 participants selected from our prevention clinic database. Multiple regression analyses were performed to evaluate associations between risk factors and SAE and LAE within the heart transplant recipients.Results: LAE and SAE were significantly lower in heart transplant recipients than in the normal cohort (P <0.01 and P < 0.0001, respectively. Female sex and history of ischemic cardiomyopathy were significantly associated with reduced LAE and SAE. Older age and the presence of moderate cardiac allograft vasculopathy were also significantly associated with reduced SAE. Transplant duration was associated with increased SAE.Conclusion: Heart transplants are associated with peripheral endothelial dysfunction and arterial stiffness, as demonstrated by a significant reduction in SAE and LAE when compared with a

  4. Basic Components of Connective Tissues and Extracellular Matrix

    DEFF Research Database (Denmark)

    Halper, Jaroslava; Kjær, Michael

    2014-01-01

    of specific organ systems, but they also provide a scaffold for elastogenesis in elastic tissues. Fibrillin is important for the assembly of elastin into elastic fibers. Mutations in the fibrillin-1 gene are closely associated with Marfan syndrome. Fibulins are tightly connected with basement membranes...

  5. Collusion and the elasticity of demand

    OpenAIRE

    David Collie

    2004-01-01

    The analysis of collusion in infinitely repeated Cournot oligopoly games has generally assumed that demand is linear, but this note uses constant-elasticity demand functions to investigate how the elasticity of demand affects the sustainability of collusion.

  6. Mechanical behaviour of nanoparticles: Elasticity and plastic ...

    Indian Academy of Sciences (India)

    2015-06-03

    Jun 3, 2015 ... Mechanical behaviour of nanoparticles: Elasticity and plastic deformation mechanisms ... The main results in terms of elasticity and plastic deformation mechanisms are then reported ... Pramana – Journal of Physics | News.

  7. The effect of elastic modulus on ablation catheter contact area.

    Science.gov (United States)

    Camp, Jon J; Linte, Cristian A; Rettmann, Maryam E; Sun, Deyu; Packer, Douglas L; Robb, Richard A; Holmes, David R

    2015-02-21

    Cardiac ablation consists of navigating a catheter into the heart and delivering RF energy to electrically isolate tissue regions that generate or propagate arrhythmia. Besides the challenges of accurate and precise targeting of the arrhythmic sites within the beating heart, limited information is currently available to the cardiologist regarding intricate electrode-tissue contact, which directly impacts the quality of produced lesions. Recent advances in ablation catheter design provide intra-procedural estimates of tissue-catheter contact force, but the most direct indicator of lesion quality for any particular energy level and duration is the tissue-catheter contact area, and that is a function of not only force, but catheter pose and material elasticity as well. In this experiment, we have employed real-time ultrasound (US) imaging to determine the complete interaction between the ablation electrode and tissue to accurately estimate contact, which will help to better understand the effect of catheter pose and position relative to the tissue. By simultaneously recording tracked position, force reading and US image of the ablation catheter, the differing material properties of polyvinyl alcohol cryogel [1] phantoms are shown to produce varying amounts of tissue depression and contact area (implying varying lesion quality) for equivalent force readings. We have shown that the elastic modulus significantly affects the surface-contact area between the catheter and tissue at any level of contact force. Thus we provide evidence that a prescribed level of catheter force may not always provide sufficient contact area to produce an effective ablation lesion in the prescribed ablation time.

  8. Quantitative Assessment of Hyaline Cartilage Elasticity During Optical Clearing Using Optical Coherence Elastography

    OpenAIRE

    Chih-Hao Liu; Manmohan Singh; Jiasong Li; Zhaolong Han; Chen Wu; Shang Wang; Rita Idugboe; Raksha Raghunathan; Emil N. Sobol; Valery V. Tuchin; Michael Twa; Kirill V. Larin

    2015-01-01

    Tissue optical clearing is an emerging technique for dynamically modifying tissue optical properties to increase imaging depth, which is useful in applications such as imaging and functional diagnostics of many diseases. For example, optical clearing of cartilage allowed imaging of subchondral bone that is used to assess orthopedic diseases. However, the effect of the clearing processes on tissue elastic properties has not been investigated yet. In this study we report the first use of phase-...

  9. Elastic least-squares reverse time migration

    KAUST Repository

    Feng, Zongcai; Schuster, Gerard T.

    2016-01-01

    Elastic least-squares reverse time migration (LSRTM) is used to invert synthetic particle-velocity data and crosswell pressure field data. The migration images consist of both the P- and Svelocity perturbation images. Numerical tests on synthetic and field data illustrate the advantages of elastic LSRTM over elastic reverse time migration (RTM). In addition, elastic LSRTM images are better focused and have better reflector continuity than do the acoustic LSRTM images.

  10. Elastic least-squares reverse time migration

    KAUST Repository

    Feng, Zongcai

    2016-09-06

    Elastic least-squares reverse time migration (LSRTM) is used to invert synthetic particle-velocity data and crosswell pressure field data. The migration images consist of both the P- and Svelocity perturbation images. Numerical tests on synthetic and field data illustrate the advantages of elastic LSRTM over elastic reverse time migration (RTM). In addition, elastic LSRTM images are better focused and have better reflector continuity than do the acoustic LSRTM images.

  11. Shear-wave elastographic features of breast cancers: comparison with mechanical elasticity and histopathologic characteristics.

    Science.gov (United States)

    Lee, Su Hyun; Moon, Woo Kyung; Cho, Nariya; Chang, Jung Min; Moon, Hyeong-Gon; Han, Wonshik; Noh, Dong-Young; Lee, Jung Chan; Kim, Hee Chan; Lee, Kyoung-Bun; Park, In-Ae

    2014-03-01

    The objective of this study was to compare the quantitative and qualitative shear-wave elastographic (SWE) features of breast cancers with mechanical elasticity and histopathologic characteristics. This prospective study was conducted with institutional review board approval, and written informed consent was obtained. Shear-wave elastography was performed for 30 invasive breast cancers in 30 women before surgery. The mechanical elasticity of a fresh breast tissue section, correlated with the ultrasound image, was measured using an indentation system. Quantitative (maximum, mean, minimum, and standard deviation of elasticity in kilopascals) and qualitative (color heterogeneity and presence of signal void areas in the mass) SWE features were compared with mechanical elasticity and histopathologic characteristics using the Pearson correlation coefficient and the Wilcoxon signed rank test. Maximum SWE values showed a moderate correlation with maximum mechanical elasticity (r = 0.530, P = 0.003). There were no significant differences between SWE values and mechanical elasticity in histologic grade I or II cancers (P = 0.268). However, SWE values were significantly higher than mechanical elasticity in histologic grade III cancers (P masses were present in 43% of breast cancers (13 of 30) and were correlated with dense collagen depositions (n = 11) or intratumoral necrosis (n = 2). Quantitative and qualitative SWE features reflect both the mechanical elasticity and histopathologic characteristics of breast cancers.

  12. Thermodynamic parameters of elasticity and electrical conductivity ...

    African Journals Online (AJOL)

    The thermodynamic parameters (change in free energy of elasticity, DGe; change in enthalpy of elasticity, DHe; and change in entropy of elasticity, DSe) and the electrical conductivity of natural rubber composites reinforced separately with some agricultural wastes have been determined. Results show that the reinforced ...

  13. On Elasticity Measurement in Cloud Computing

    Directory of Open Access Journals (Sweden)

    Wei Ai

    2016-01-01

    Full Text Available Elasticity is the foundation of cloud performance and can be considered as a great advantage and a key benefit of cloud computing. However, there is no clear, concise, and formal definition of elasticity measurement, and thus no effective approach to elasticity quantification has been developed so far. Existing work on elasticity lack of solid and technical way of defining elasticity measurement and definitions of elasticity metrics have not been accurate enough to capture the essence of elasticity measurement. In this paper, we present a new definition of elasticity measurement and propose a quantifying and measuring method using a continuous-time Markov chain (CTMC model, which is easy to use for precise calculation of elasticity value of a cloud computing platform. Our numerical results demonstrate the basic parameters affecting elasticity as measured by the proposed measurement approach. Furthermore, our simulation and experimental results validate that the proposed measurement approach is not only correct but also robust and is effective in computing and comparing the elasticity of cloud platforms. Our research in this paper makes significant contribution to quantitative measurement of elasticity in cloud computing.

  14. Morphological alterations in the elastic fibers of the rabbit craniomandibular joint following experimentally induced anterior disk displacement.

    Science.gov (United States)

    Ali, A M; Sharawy, M; O'Dell, N L; al-Behery, G

    1993-01-01

    Elastic fibers are important components of the connective tissue that attaches the articular disk of the craniomandibular joint (CMJ) to the skull and mandible. Biopsies of the articular disk proper and bilaminar zone (BZ) tissues from patients with anterior disk displacement (ADD) have shown previously that there is a marked loss of elastic fibers. In the present study, the effects of inducing ADD on the elastic fibers in the rabbit CMJ disk proper, BZ and condylar cartilage were investigated. The right CMJ was exposed surgically and the discal attachments were severed except for the BZ attachments. Then, the disk was displaced anteriorly and sutured to the zygomatic arch. The CMJs were removed after 1, 2 or 6 weeks and processed for histochemical demonstration of elastic fibers. The results showed osteoarthritic changes following ADD, and a significant decrease in the number of the elastic fibers in the disk proper and BZ. The remaining elastic fibers were abnormal in their appearance and orientation. In addition, ADD led to the appearance of fine elastic fibers among the chondrocytes in the hyaline cartilage of the condyle that were not present in the cartilage of the control condyle. We conclude that induced ADD can lead to a significant loss of elastic fibers in the articular disk, and result in the appearance of elastic fibers within the cartilage of the mandibular condyle.

  15. Elasticity of Relativistic Rigid Bodies?

    Science.gov (United States)

    Smarandache, Florentin

    2013-10-01

    In the classical Twin Paradox, according to the Special Theory of Relativity, when the traveling twin blasts off from the Earth to a relative velocity v =√{/3 } 2 c with respect to the Earth, his measuring stick and other physical objects in the direction of relative motion shrink to half their lengths. How is that possible in the real physical world to have let's say a rigid rocket shrinking to half and then later elongated back to normal as an elastic material when it stops? What is the explanation for the traveler's measuring stick and other physical objects, in effect, return to the same length to their original length in the Stay-At-Home, but there is no record of their having shrunk? If it's a rigid (not elastic) object, how can it shrink and then elongate back to normal? It might get broken in such situation.

  16. Elasticity of Long Distance Travelling

    DEFF Research Database (Denmark)

    Knudsen, Mette Aagaard

    2011-01-01

    With data from the Danish expenditure survey for 12 years 1996 through 2007, this study analyses household expenditures for long distance travelling. Household expenditures are examined at two levels of aggregation having the general expenditures on transportation and leisure relative to five other...... aggregated commodities at the highest level, and the specific expenditures on plane tickets and travel packages at the lowest level. The Almost Ideal Demand System is applied to determine the relationship between expenditures on transportation and leisure and all other purchased non-durables within...... packages has higher income elasticity of demand than plane tickets but also higher than transportation and leisure in general. The findings within price sensitiveness are not as sufficient estimated, but the model results indicate that travel packages is far more price elastic than plane tickets which...

  17. Derivation of elastic stiffness from site-matched mineral density and acoustic impedance maps

    International Nuclear Information System (INIS)

    Raum, Kay; Cleveland, Robin O; Peyrin, Francoise; Laugier, Pascal

    2006-01-01

    200 MHz acoustic impedance maps and site-matched synchrotron radiation micro computed tomography (SR-μCT) maps of tissue degree of mineralization of bone (DMB) were used to derive the elastic coefficient c 33 in cross sections of human cortical bone. To accomplish this goal, a model was developed to relate the DMB accessible with SR-μCT to mass density. The formulation incorporates the volume fractions and densities of the major bone tissue components (collagen, mineral and water), and accounts for tissue porosity. We found that the mass density can be well modelled by a second-order polynomial fit to DMB (R 2 = 0.999) and appears to be consistent with measurements of many different types of mineralized tissues. The derived elastic coefficient c 33 correlated more strongly with the acoustic impedance (R 2 = 0.996) than with mass density (R 2 = 0.310). This finding suggests that estimates of c 33 made from measurements of the acoustic impedance are more reliable than those made from density measurements. Mass density and elastic coefficient were in the range between 1.66 and 2.00 g cm -3 and 14.8 and 75.4 GPa, respectively. Although SAM inspection is limited to the evaluation of carefully prepared sample surfaces, it provides a two-dimensional quantitative estimate of elastic tissue properties at the tissue level

  18. Pipeline robots with elastic elements

    Directory of Open Access Journals (Sweden)

    A. Matuliauskas

    2002-10-01

    Full Text Available In the article constructions of the pipeline robots with elastic elements are reviewed and the scheme of new original construction is presented. The mathematical models of a robot with one-dimensional vibration exciter with two degrees of freedom were developed and the equations of movement were formed and written. The mathematical model of the pipeline robot with circular elements is formed and its motion equations are presented.

  19. The poverty elasticity of growth

    OpenAIRE

    Heltberg, Rasmus

    2002-01-01

    How much does economic growth contribute to poverty reduction? I discuss analytical and empirical approches to assess the poverty elasticity of growth, and emphasize that the relationship between growth and poverty change is non-constant. For a given poverty measure, it depends on initial inequality and on the location of the poverty line relative to mean income. In most cases, growth is more important for poverty reduction than changes in inequality, but this does not tender inequality unimp...

  20. Transient waves in visco-elastic media

    CERN Document Server

    Ricker, Norman

    1977-01-01

    Developments in Solid Earth Geophysics 10: Transient Waves in Visco-Elastic Media deals with the propagation of transient elastic disturbances in visco-elastic media. More specifically, it explores the visco-elastic behavior of a medium, whether gaseous, liquid, or solid, for very-small-amplitude disturbances. This volume provides a historical overview of the theory of the propagation of elastic waves in solid bodies, along with seismic prospecting and the nature of seismograms. It also discusses the seismic experiments, the behavior of waves propagated in accordance with the Stokes wave

  1. Teaching nonlinear dynamics through elastic cords

    International Nuclear Information System (INIS)

    Chacon, R; Galan, C A; Sanchez-Bajo, F

    2011-01-01

    We experimentally studied the restoring force of a length of stretched elastic cord. A simple analytical expression for the restoring force was found to fit all the experimental results for different elastic materials. Remarkably, this analytical expression depends upon an elastic-cord characteristic parameter which exhibits two limiting values corresponding to two nonlinear springs with different Hooke's elastic constants. Additionally, the simplest model of elastic cord dynamics is capable of exhibiting a great diversity of nonlinear phenomena, including bifurcations and chaos, thus providing a suitable alternative model system for discussing the basic essentials of nonlinear dynamics in the context of intermediate physics courses at university level.

  2. Elastic interaction between surface and spherical pore

    International Nuclear Information System (INIS)

    Ganeev, G.Z.; Kadyrzhanov, K.K.; Kislitsyn, S.B.; Turkebaev, T.Eh.

    2000-01-01

    The energy of elastic interaction of a gas-filled spherical cavity with a boundary of an elastic isotropic half-space is determined. The elastic field of a system of a spherical cavity - boundary is represented as an expansion in series of potential functions. The factors of expansions are determined by boundary conditions on a free surface of an elastic half-space and on a spherical surface of a cavity with pressure of gas P. Function of a Tresca-Miesesa on a surface of elastic surface is defined additionally with purpose creep condition determination caused by gas pressure in the cavity. (author)

  3. Elastic scattering at the LHC

    CERN Document Server

    Kaspar, Jan; Deile, M

    The seemingly simple elastic scattering of protons still presents a challenge for the theory. In this thesis we discuss the elastic scattering from theoretical as well as experimental point of view. In the theory part, we present several models and their predictions for the LHC. We also discuss the Coulomb-hadronic interference, where we present a new eikonal calculation to all orders of alpha, the fine-structure constant. In the experimental part we introduce the TOTEM experiment which is dedicated, among other subjects, to the measurement of the elastic scattering at the LHC. This measurement is performed primarily with the Roman Pot (RP) detectors - movable beam-pipe insertions hundreds of meters from the interaction point, that can detect protons scattered to very small angles. We discuss some aspects of the RP simulation and reconstruction software. A central point is devoted to the techniques of RP alignment - determining the RP sensor positions relative to each other and to the beam. At the end we pres...

  4. Distribution of elastic fibers in the head and neck: a histological study using late-stage human fetuses

    Science.gov (United States)

    Kinoshita, Hideaki; Umezawa, Takashi; Omine, Yuya; Kasahara, Masaaki; Rodríguez-Vázquez, José Francisco; Murakami, Gen

    2013-01-01

    There is little or no information about the distribution of elastic fibers in the human fetal head. We examined this issue in 15 late-stage fetuses (crown-rump length, 220-320 mm) using aldehyde-fuchsin and elastica-Masson staining, and we used the arterial wall elastic laminae and external ear cartilages as positive staining controls. The posterior pharyngeal wall, as well as the ligaments connecting the laryngeal cartilages, contained abundant elastic fibers. In contrast with the sphenomandibular ligament and the temporomandibular joint disk, in which elastic fibers were partly present, the discomalleolar ligament and the fascial structures around the pterygoid muscles did not have any elastic fibers. In addition, the posterior marginal fascia of the prestyloid space did contain such fibers. Notably, in the middle ear, elastic fibers accumulated along the tendons of the tensor tympani and stapedius muscles and in the joint capsules of the ear ossicle articulations. Elastic fibers were not seen in any other muscle tendons or vertebral facet capsules in the head and neck. Despite being composed of smooth muscle, the orbitalis muscle did not contain any elastic fibers. The elastic fibers in the sphenomandibular ligament seemed to correspond to an intermediate step of development between Meckel's cartilage and the final ligament. Overall, there seemed to be a mini-version of elastic fiber distribution compared to that in adults and a different specific developmental pattern of connective tissues. The latter morphology might be a result of an adaptation to hypoxic conditions during development. PMID:23560235

  5. Distribution of elastic fibers in the head and neck: a histological study using late-stage human fetuses.

    Science.gov (United States)

    Kinoshita, Hideaki; Umezawa, Takashi; Omine, Yuya; Kasahara, Masaaki; Rodríguez-Vázquez, José Francisco; Murakami, Gen; Abe, Shinichi

    2013-03-01

    There is little or no information about the distribution of elastic fibers in the human fetal head. We examined this issue in 15 late-stage fetuses (crown-rump length, 220-320 mm) using aldehyde-fuchsin and elastica-Masson staining, and we used the arterial wall elastic laminae and external ear cartilages as positive staining controls. The posterior pharyngeal wall, as well as the ligaments connecting the laryngeal cartilages, contained abundant elastic fibers. In contrast with the sphenomandibular ligament and the temporomandibular joint disk, in which elastic fibers were partly present, the discomalleolar ligament and the fascial structures around the pterygoid muscles did not have any elastic fibers. In addition, the posterior marginal fascia of the prestyloid space did contain such fibers. Notably, in the middle ear, elastic fibers accumulated along the tendons of the tensor tympani and stapedius muscles and in the joint capsules of the ear ossicle articulations. Elastic fibers were not seen in any other muscle tendons or vertebral facet capsules in the head and neck. Despite being composed of smooth muscle, the orbitalis muscle did not contain any elastic fibers. The elastic fibers in the sphenomandibular ligament seemed to correspond to an intermediate step of development between Meckel's cartilage and the final ligament. Overall, there seemed to be a mini-version of elastic fiber distribution compared to that in adults and a different specific developmental pattern of connective tissues. The latter morphology might be a result of an adaptation to hypoxic conditions during development.

  6. Optical diagnostics based on elastic scattering: An update of clinical demonstrations with the Optical Biopsy System

    Energy Technology Data Exchange (ETDEWEB)

    Bigio, I.J.; Boyer, J.; Johnson, T.M.; Lacey, J.; Mourant, J.R. [Los Alamos National Lab., NM (United States); Conn, R. [Lovelace Medical Center, Albuquerque, NM (United States); Bohorfoush, A. [Wisconsin Medical School, Milwaukee, WI (United States)

    1994-10-01

    The Los Alamos National Laboratory has continued the development of the Optical Biopsy System (OBS) for noninvasive, real-time in situ diagnosis of tissue pathologies. Our clinical studies have expanded since the last Biomedical Optics Europe conference (Budapest, September 1993), and we report here on the latest results of clinical tests in gastrointestinal tract. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the tissue. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength-dependence of elastic scattering. The OBS employs a small fiberoptic probe that is amenable to use with any endoscope or catheter, or to direct surface examination. The probe is designed to be used in optical contact with the tissue under examination and has separate illuminating and collecting fibers. Thus, the light that is collected and transmitted to the analyzing spectrometer must first scatter through a small volume of the tissue before entering the collection fiber(s). Consequently, the system is also sensitive to the optical absorption spectrum of the tissue, over an effective operating range of <300 to 950 nm, and such absorption adds valuable complexity to the scattering spectral signature.

  7. Motivation and compliance with intraoral elastics.

    Science.gov (United States)

    Veeroo, Helen J; Cunningham, Susan J; Newton, Jonathon Timothy; Travess, Helen C

    2014-07-01

    Intraoral elastics are commonly used in orthodontics and require regular changing to be effective. Unfortunately, poor compliance with elastics is often encountered, especially in adolescents. Intention for an action and its implementation can be improved using "if-then" plans that spell out when, where, and how a set goal, such as elastic wear, can be put into action. Our aim was to determine the effect of if-then plans on compliance with elastics. To identify common barriers to compliance with recommendations concerning elastic wear, semistructured interviews were carried out with 14 adolescent orthodontic patients wearing intraoral elastics full time. Emerging themes were used to develop if-then plans to improve compliance with elastic wear. A prospective pilot study assessed the effectiveness of if-then planning aimed at overcoming the identified barriers on compliance with elastic wear. Twelve participants were randomized equally into study and control groups; the study group received information about if-then planning. The participants were asked to collect used elastics, and counts of these were used to assess compliance. A wide range of motivational and volitional factors were described by the interviewed participants, including the perceived benefits of elastics, cues to remember, pain, eating, social situations, sports, loss of elastics, and breakages. Compliance with elastic wear was highly variable among patients. The study group returned more used elastics, suggesting increased compliance, but the difference was not significant. The use of if-then plans might improve compliance with elastic wear when compared with routine clinical instructions. Copyright © 2014 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  8. Quantitative assessment of hyaline cartilage elasticity during optical clearing using optical coherence elastography

    Science.gov (United States)

    Liu, Chih-Hao; Singh, Manmohan; Li, Jiasong; Han, Zhaolong; Wu, Chen; Wang, Shang; Idugboe, Rita; Raghunathan, Raksha; Zakharov, Valery P.; Sobol, Emil N.; Tuchin, Valery V.; Twa, Michael; Larin, Kirill V.

    2015-03-01

    We report the first study on using optical coherence elastography (OCE) to quantitatively monitor the elasticity change of the hyaline cartilage during the optical clearing administrated by glucose solution. The measurement of the elasticity is verified using uniaxial compression test, demonstrating the feasibility of using OCE to quantify the Young's modulus of the cartilage tissue. As the results, we found that the stiffness of the hyaline cartilage increases during the optical clearing of the tissue. This study might be potentially useful for the early detection of osteoarthritis disease.

  9. Wave motion in elastic solids

    CERN Document Server

    Graff, Karl F

    1991-01-01

    This highly useful textbook presents comprehensive intermediate-level coverage of nearly all major topics of elastic wave propagation in solids. The subjects range from the elementary theory of waves and vibrations in strings to the three-dimensional theory of waves in thick plates. The book is designed not only for a wide audience of engineering students, but also as a general reference for workers in vibrations and acoustics. Chapters 1-4 cover wave motion in the simple structural shapes, namely strings, longitudinal rod motion, beams and membranes, plates and (cylindrical) shells. Chapter

  10. Elastic Moduli of Carbon Nanohorns

    Directory of Open Access Journals (Sweden)

    Dinesh Kumar

    2011-01-01

    Full Text Available Carbon nanotube is a special case of carbon nanohorns or carbon nanocones with zero apex angle. Research into carbon nanohorns started almost at the same time as the discovery of nanotubes in 1991. Most researchers focused on the investigation of nanotubes, and the exploration of nanohorns attracted little attention. To model the carbon nanohorns, we make use of a more reliable second-generation reactive empirical bond-order potential by Brenner and coworkers. We investigate the elastic moduli and conclude that these nanohorns are equally strong and require in-depth investigation. The values of Young's and Shear moduli decrease with apex angle.

  11. Wave propagation in elastic solids

    CERN Document Server

    Achenbach, Jan

    1984-01-01

    The propagation of mechanical disturbances in solids is of interest in many branches of the physical scienses and engineering. This book aims to present an account of the theory of wave propagation in elastic solids. The material is arranged to present an exposition of the basic concepts of mechanical wave propagation within a one-dimensional setting and a discussion of formal aspects of elastodynamic theory in three dimensions, followed by chapters expounding on typical wave propagation phenomena, such as radiation, reflection, refraction, propagation in waveguides, and diffraction. The treat

  12. Surface elastic properties in silicon nanoparticles

    Science.gov (United States)

    Melis, Claudio; Giordano, Stefano; Colombo, Luciano

    2017-09-01

    The elastic behavior of the external surface of a solid body plays a key role in nanomechanical phenomena. While bulk elasticity enjoys the benefits of a robust theoretical understanding, many surface elasticity features remain unexplored: some of them are here addressed by blending together continuum elasticity and atomistic simulations. A suitable readdressing of the surface elasticity theory allows to write the balance equations in arbitrary curvilinear coordinates and to investigate the dependence of the surface elastic parameters on the mean and Gaussian curvatures of the surface. In particular, we predict the radial strain induced by surface effects in spherical and cylindrical silicon nanoparticles and provide evidence that the surface parameters are nearly independent of curvatures and, therefore, of the surface conformation.

  13. Elastic properties of spherically anisotropic piezoelectric composites

    International Nuclear Information System (INIS)

    En-Bo, Wei; Guo-Qing, Gu; Ying-Ming, Poon

    2010-01-01

    Effective elastic properties of spherically anisotropic piezoelectric composites, whose spherically anisotropic piezoelectric inclusions are embedded in an infinite non-piezoelectric matrix, are theoretically investigated. Analytical solutions for the elastic displacements and the electric potentials under a uniform external strain are derived exactly. Taking into account of the coupling effects of elasticity, permittivity and piezoelectricity, the formula is derived for estimating the effective elastic properties based on the average field theory in the dilute limit. An elastic response mechanism is revealed, in which the effective elastic properties increase as inclusion piezoelectric properties increase and inclusion dielectric properties decrease. Moreover, a piezoelectric response mechanism, of which the effective piezoelectric response vanishes due to the symmetry of spherically anisotropic composite, is also disclosed. (condensed matter: structure, thermal and mechanical properties)

  14. Effective elastic properties of damaged isotropic solids

    International Nuclear Information System (INIS)

    Lee, U Sik

    1998-01-01

    In continuum damage mechanics, damaged solids have been represented by the effective elastic stiffness into which local damage is smoothly smeared. Similarly, damaged solids may be represented in terms of effective elastic compliances. By virtue of the effective elastic compliance representation, it may become easier to derive the effective engineering constants of damaged solids from the effective elastic compliances, all in closed form. Thus, in this paper, by using a continuum modeling approach based on both the principle of strain energy equivalence and the equivalent elliptical micro-crack representation of local damage, the effective elastic compliance and effective engineering constants are derived in terms of the undamaged (virgin) elastic properties and a scalar damage variable for both damaged two-and three-dimensional isotropic solids

  15. Anomalous elasticity, fluctuations and disorder in elastic membranes

    Science.gov (United States)

    Le Doussal, Pierre; Radzihovsky, Leo

    2018-05-01

    Motivated by freely suspended graphene and polymerized membranes in soft and biological matter we present a detailed study of a tensionless elastic sheet in the presence of thermal fluctuations and quenched disorder. The manuscript is based on an extensive draft dating back to 1993, that was circulated privately. It presents the general theoretical framework and calculational details of numerous results, partial forms of which have been published in brief Letters (Le Doussal and Radzihovsky, 1992; 1993). The experimental realization atom-thin graphene sheets (Novoselov et al., 2004) have driven a resurgence in this fascinating subject, making our dated predictions and their detailed derivations timely. To this end we analyze the statistical mechanics of a generalized D-dimensional elastic "membrane" embedded in d dimensions using a self-consistent screening approximation (SCSA), that has proved to be unprecedentedly accurate in this system, exact in three complementary limits: (i) d → ∞, (ii) D → 4, and (iii) D = d. Focusing on the critical "flat" phase, for a homogeneous two-dimensional (D = 2) membrane embedded in three dimensions (d = 3), we predict its universal roughness exponent ζ = 0 . 590, length-scale dependent elastic moduli exponents η = 0 . 821 and ηu = 0 . 358, and an anomalous Poisson ratio, σ = - 1 / 3. In the presence of random uncorrelated heterogeneity the membrane exhibits a glassy wrinkled ground state, characterized by ζ‧ = 0 . 775 ,η‧ = 0 . 449, ηu‧ = 1 . 101 and a Poisson ratio σ‧ = - 1 / 3. Motivated by a number of physical realizations (charged impurities, disclinations and dislocations) we also study power-law correlated quenched disorder that leads to a variety of distinct glassy wrinkled phases. Finally, neglecting self-avoiding interaction we demonstrate that at high temperature a "phantom" sheet undergoes a continuous crumpling transition, characterized by a radius of gyration exponent, ν = 0 . 732 and η = 0

  16. Continuum mechanics elasticity, plasticity, viscoelasticity

    CERN Document Server

    Dill, Ellis H

    2006-01-01

    FUNDAMENTALS OF CONTINUUM MECHANICSMaterial ModelsClassical Space-TimeMaterial BodiesStrainRate of StrainCurvilinear Coordinate SystemsConservation of MassBalance of MomentumBalance of EnergyConstitutive EquationsThermodynamic DissipationObjectivity: Invariance for Rigid MotionsColeman-Mizel ModelFluid MechanicsProblems for Chapter 1BibliographyNONLINEAR ELASTICITYThermoelasticityMaterial SymmetriesIsotropic MaterialsIncompressible MaterialsConjugate Measures of Stress and StrainSome Symmetry GroupsRate Formulations for Elastic MaterialsEnergy PrinciplesGeometry of Small DeformationsLinear ElasticitySpecial Constitutive Models for Isotropic MaterialsMechanical Restrictions on the Constitutive RelationsProblems for Chapter 2BibliographyLINEAR ELASTICITYBasic EquationsPlane StrainPlane StressProperties of SolutionsPotential EnergySpecial Matrix NotationThe Finite Element Method of SolutionGeneral Equations for an Assembly of ElementsFinite Element Analysis for Large DeformationsProblems for Chapter 3Bibliograph...

  17. Pneumatic Variable Series Elastic Actuator.

    Science.gov (United States)

    Zheng, Hao; Wu, Molei; Shen, Xiangrong

    2016-08-01

    Inspired by human motor control theory, stiffness control is highly effective in manipulation and human-interactive tasks. The implementation of stiffness control in robotic systems, however, has largely been limited to closed-loop control, and suffers from multiple issues such as limited frequency range, potential instability, and lack of contribution to energy efficiency. Variable-stiffness actuator represents a better solution, but the current designs are complex, heavy, and bulky. The approach in this paper seeks to address these issues by using pneumatic actuator as a variable series elastic actuator (VSEA), leveraging the compressibility of the working fluid. In this work, a pneumatic actuator is modeled as an elastic element with controllable stiffness and equilibrium point, both of which are functions of air masses in the two chambers. As such, for the implementation of stiffness control in a robotic system, the desired stiffness/equilibrium point can be converted to the desired chamber air masses, and a predictive pressure control approach is developed to control the timing of valve switching to obtain the desired air mass while minimizing control action. Experimental results showed that the new approach in this paper requires less expensive hardware (on-off valve instead of proportional valve), causes less control action in implementation, and provides good control performance by leveraging the inherent dynamics of the actuator.

  18. Hummingbird tongues are elastic micropumps

    Science.gov (United States)

    Rico-Guevara, Alejandro; Fan, Tai-Hsi; Rubega, Margaret A.

    2015-01-01

    Pumping is a vital natural process, imitated by humans for thousands of years. We demonstrate that a hitherto undocumented mechanism of fluid transport pumps nectar onto the hummingbird tongue. Using high-speed cameras, we filmed the tongue–fluid interaction in 18 hummingbird species, from seven of the nine main hummingbird clades. During the offloading of the nectar inside the bill, hummingbirds compress their tongues upon extrusion; the compressed tongue remains flattened until it contacts the nectar. After contact with the nectar surface, the tongue reshapes filling entirely with nectar; we did not observe the formation of menisci required for the operation of capillarity during this process. We show that the tongue works as an elastic micropump; fluid at the tip is driven into the tongue's grooves by forces resulting from re-expansion of a collapsed section. This work falsifies the long-standing idea that capillarity is an important force filling hummingbird tongue grooves during nectar feeding. The expansive filling mechanism we report in this paper recruits elastic recovery properties of the groove walls to load nectar into the tongue an order of magnitude faster than capillarity could. Such fast filling allows hummingbirds to extract nectar at higher rates than predicted by capillarity-based foraging models, in agreement with their fast licking rates. PMID:26290074

  19. Elastic properties of graphite and interstitial defects

    International Nuclear Information System (INIS)

    Ayasse, J.-B.

    1977-01-01

    The graphite elastic constants C 33 and C 44 , reflecting the interaction of the graphitic planes, were experimentally measured as a function of irradiation and temperature. A model of non-central strength atomic interaction was established to explain the experimental results obtained. This model is valid at zero temperature. The temperature dependence of the elastic properties was analyzed. The influence of the elastic property variations on the specific heat of the lattice at very low temperature was investigated [fr

  20. Brazilian sawn wood price and income elasticity

    Directory of Open Access Journals (Sweden)

    Rommel Noce

    2010-09-01

    Full Text Available This study estimated the sawn wood demand price and income elasticity. Specifically it was estimated the priceelasticity of sawn wood, the cross price elasticity of wood panels and the income elasticity of Brazilian GDP. A log-log model withcorrection through outline of the mobile average (MA(1 was used, adjusted for the period of 1971 to 2006, which showed to bestable, with satisfactory significance levels. It was observed that sawn wood demand is inelastic in relation to price and elastic inrelation to income.

  1. Elastic properties of icosahedral and decagonal quasicrystals

    International Nuclear Information System (INIS)

    Chernikov, Mikhail A

    2005-01-01

    Problems associated with determining the symmetry properties of the elastic constant tensor of icosahedral and decagonal quasicrystals are reviewed. Notions of elastic isotropy and anisotropy are considered, and their relation to the components of the elastic constant tensor is discussed. The question is addressed of how to determine experimentally whether a system under study is elastically isotropic. Experimental results produced by resonant ultrasound spectroscopy of icosahedral Al-Li-Cu and decagonal Al-Ni-Co single quasicrystals are discussed in detail. (methodological notes)

  2. Faraday wave lattice as an elastic metamaterial.

    Science.gov (United States)

    Domino, L; Tarpin, M; Patinet, S; Eddi, A

    2016-05-01

    Metamaterials enable the emergence of novel physical properties due to the existence of an underlying subwavelength structure. Here, we use the Faraday instability to shape the fluid-air interface with a regular pattern. This pattern undergoes an oscillating secondary instability and exhibits spontaneous vibrations that are analogous to transverse elastic waves. By locally forcing these waves, we fully characterize their dispersion relation and show that a Faraday pattern presents an effective shear elasticity. We propose a physical mechanism combining surface tension with the Faraday structured interface that quantitatively predicts the elastic wave phase speed, revealing that the liquid interface behaves as an elastic metamaterial.

  3. Elastic moduli and elastic anisotropy of cold sprayed metallic coatings

    Czech Academy of Sciences Publication Activity Database

    Seiner, Hanuš; Cizek, J.; Sedlák, Petr; Huang, R.; Cupera, J.; Dlouhý, I.; Landa, Michal

    2016-01-01

    Roč. 291, April (2016), s. 342-347 ISSN 0257-8972 R&D Projects: GA ČR GA13-13616S; GA ČR(CZ) GA13-35890S Grant - others:NETME Centre Plus - národní program udržitelnosti(CZ) LO1202 Institutional support: RVO:61388998 Keywords : kinetic spray * CGDS * elastic properties * metals and alloys * deposition * resonant ultrasound spectroscopy Subject RIV: JG - Metallurgy Impact factor: 2.589, year: 2016 http://ac.els-cdn.com/S0257897216301165/1-s2.0-S0257897216301165-main.pdf?_tid=1083617a-017f-11e6-92e7-00000aacb361&acdnat=1460555773_2e80d3df20843f3af649bf3ac71c8844

  4. Elastic electron scattering from the DNA bases cytosine and thymine

    International Nuclear Information System (INIS)

    Colyer, C. J.; Bellm, S. M.; Lohmann, B.; Blanco, F.; Garcia, G.

    2011-01-01

    Cross-section data for electron scattering from biologically relevant molecules are important for the modeling of energy deposition in living tissue. Relative elastic differential cross sections have been measured for cytosine and thymine using the crossed-beam method. These measurements have been performed for six discrete electron energies between 60 and 500 eV and for detection angles between 15 deg. and 130 deg. Calculations have been performed via the screen-corrected additivity rule method and are in good agreement with the present experiment.

  5. Tissue engineering

    CERN Document Server

    Fisher, John P; Bronzino, Joseph D

    2007-01-01

    Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue Engineering disseminates current thinking on the development of engineered tissues. Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene t...

  6. Elastin as a biomaterial for tissue engineering.

    NARCIS (Netherlands)

    Daamen, W.F.; Veerkamp, J.H.; Hest, J.C.M. van; Kuppevelt, A.H.M.S.M. van

    2007-01-01

    Biomaterials based upon elastin and elastin-derived molecules are increasingly investigated for their application in tissue engineering. This interest is fuelled by the remarkable properties of this structural protein, such as elasticity, self-assembly, long-term stability, and biological activity.

  7. Optical diagnostics based on elastic scattering: Recent clinical demonstrations with the Los Alamos Optical Biopsy System

    Energy Technology Data Exchange (ETDEWEB)

    Bigio, I.J.; Loree, T.R.; Mourant, J.; Shimada, T. [Los Alamos National Lab., NM (United States); Story-Held, K.; Glickman, R.D. [Texas Univ. Health Science Center, San Antonio, TX (United States). Dept. of Ophthalmology; Conn, R. [Lovelace Medical Center, Albuquerque, NM (United States). Dept. of Urology

    1993-08-01

    A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, manifest significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be strongly wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes in an optical signature that is derived from the wavelength dependence of elastic scattering. The data acquisition and storage/display time with the OBS instrument is {approximately}1 second. Thus, in addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope, catheter or hypodermic, or to direct surface examination (e.g. as in skin cancer or cervical cancer). It has been tested in vitro on animal and human tissue samples, and clinical testing in vivo is currently in progress.

  8. Modelling elasticity in solids using active cubes - application to simulated operations

    DEFF Research Database (Denmark)

    Bro-Nielsen, Morten

    1995-01-01

    The paper describes an approach to elastic modelling of human tissue based on the use of 3D solid active models-active cubes (M. Bro-Nielsen, 1994)-and a shape description based on the metric tensor in a solid. Active cubes are used because they provide a natural parameterization of the surface a...

  9. Visual detectability of elastic contrast in real-time ultrasound images

    Science.gov (United States)

    Miller, Naomi R.; Bamber, Jeffery C.; Doyley, Marvin M.; Leach, Martin O.

    1997-04-01

    Elasticity imaging (EI) has recently been proposed as a technique for imaging the mechanical properties of soft tissue. However, dynamic features, known as compressibility and mobility, are already employed to distinguish between different tissue types in ultrasound breast examination. This method, which involves the subjective interpretation of tissue motion seen in real-time B-mode images during palpation, is hereafter referred to as differential motion imaging (DMI). The purpose of this study was to develop the methodology required to perform a series of perception experiments to measure elastic lesion detectability by means of DMI and to obtain preliminary results for elastic contrast thresholds for different lesion sizes. Simulated sequences of real-time B-scans of tissue moving in response to an applied force were generated. A two-alternative forced choice (2-AFC) experiment was conducted and the measured contrast thresholds were compared with published results for lesions detected by EI. Although the trained observer was found to be quite skilled at the task of differential motion perception, it would appear that lesion detectability is improved when motion information is detected by computer processing and converted to gray scale before presentation to the observer. In particular, for lesions containing fewer than eight speckle cells, a signal detection rate of 100% could not be achieved even when the elastic contrast was very high.

  10. Quasi-experimental taxation elasticities of US gasoline demand

    International Nuclear Information System (INIS)

    Goel, R.K.

    1994-01-01

    Taxation elasticities provide inputs in public policy aimed at raising revenues. Using the quasi-experimental method, this paper calculates gasoline taxation elasticities for the USA over 1952-86. The medium (mean) elasticity over this period is found to be -0.075 (-0.122). However, the elasticity following the oil shock of 1973 is found to be statistically different from the pre-shock elasticity. Reasons for this change in elasticity are discussed. The implication of this analysis is that tax policies based on price elasticities, rather than on tax elasticities, might be using an inappropriate elasticity estimate and consequently misinterpreting the government's ability to raise tax revenues. (author)

  11. Multidiscipline simulation of elastic manipulators

    Directory of Open Access Journals (Sweden)

    T. Rølvåg

    1992-10-01

    Full Text Available This paper contributes to multidiscipline simulation of elastic robot manipulators in FEDEM. All developments presented in this paper are based on the formulations in FEDEM, a simulation system developed by the authors which combines finite element, mechanism and control analysis. In order to establish this general simulation system as an efficient multidiscipline robot design tool a robot control system including a high level robot programming language, interpolation algorithms, path generation algorithms, forward and inverse kinematics, control systems, gear and transmission models are implemented. These new features provide a high level of integration between traditionally separate design disciplines from the very beginning of the design and optimization process. Several simulations have shown that high fidelity mathematical models can be derived and used as a basis for dynamic analysis and controller design in FEDEM.

  12. Wrinkling of Pressurized Elastic Shells

    KAUST Repository

    Vella, Dominic

    2011-10-01

    We study the formation of localized structures formed by the point loading of an internally pressurized elastic shell. While unpressurized shells (such as a ping-pong ball) buckle into polygonal structures, we show that pressurized shells are subject to a wrinkling instability. We study wrinkling in depth, presenting scaling laws for the critical indentation at which wrinkling occurs and the number of wrinkles formed in terms of the internal pressurization and material properties of the shell. These results are validated by numerical simulations. We show that the evolution of the wrinkle length with increasing indentation can be understood for highly pressurized shells from membrane theory. These results suggest that the position and number of wrinkles may be used in combination to give simple methods for the estimation of the mechanical properties of highly pressurized shells. © 2011 American Physical Society.

  13. Mathematical methods for elastic plates

    CERN Document Server

    Constanda, Christian

    2014-01-01

    Mathematical models of deformation of elastic plates are used by applied mathematicians and engineers in connection with a wide range of practical applications, from microchip production to the construction of skyscrapers and aircraft. This book employs two important analytic techniques to solve the fundamental boundary value problems for the theory of plates with transverse shear deformation, which offers a more complete picture of the physical process of bending than Kirchhoff’s classical one.   The first method transfers the ellipticity of the governing system to the boundary, leading to singular integral equations on the contour of the domain. These equations, established on the basis of the properties of suitable layer potentials, are then solved in spaces of smooth (Hölder continuous and Hölder continuously differentiable) functions.   The second technique rewrites the differential system in terms of complex variables and fully integrates it, expressing the solution as a combination of complex ana...

  14. The visco-elastic multilayer program VEROAD

    NARCIS (Netherlands)

    Hopman, P.C.

    1996-01-01

    The mathematical principles and derivation of a linear visco-elastic multilayer computer program are described. The mathematical derivation is based on Fourier Transformation. The program is called VEROAD, which is an acronym for Visco-Elastic ROad Analysis Delft. The program allows calculation of

  15. Heavy ion elastic scattering of code : OPTHI

    International Nuclear Information System (INIS)

    Ismail, M.; Divatia, A.S.

    1982-01-01

    A computer code, OPTHI has been designed to calculate nuclear optical model elastic cross sections for the scattering of heavy ions. The program has been designed to be utilitarian rather than capable of giving an exact description of elastic scattering. Input format is described and the program listing is given. (M.G.B.)

  16. Dynamic elasticity measurement for prosthetic socket design.

    Science.gov (United States)

    Kim, Yujin; Kim, Junghoon; Son, Hyeryon; Choi, Youngjin

    2017-07-01

    The paper proposes a novel apparatus to measure the dynamic elasticity of human limb in order to help the design and fabrication of the personalized prosthetic socket. To take measurements of the dynamic elasticity, the desired force generated as an exponential chirp signal in which the frequency increases and amplitude is maintained according to time progress is applied to human limb and then the skin deformation is recorded, ultimately, to obtain the frequency response of its elasticity. It is referred to as a Dynamic Elasticity Measurement Apparatus (DEMA) in the paper. It has three core components such as linear motor to provide the desired force, loadcell to implement the force feedback control, and potentiometer to record the skin deformation. After measuring the force/deformation and calculating the dynamic elasticity of the limb, it is visualized as 3D color map model of the limb so that the entire dynamic elasticity can be shown at a glance according to the locations and frequencies. For the visualization, the dynamic elasticities measured at specific locations and frequencies are embodied using the color map into 3D limb model acquired by using 3D scanner. To demonstrate the effectiveness, the visualized dynamic elasticities are suggested as outcome of the proposed system, although we do not have any opportunity to apply the proposed system to the amputees. Ultimately, it is expected that the proposed system can be utilized to design and fabricate the personalized prosthetic socket in order for releasing the wearing pain caused by the conventional prosthetic socket.

  17. 7 CFR 29.2515 - Elasticity.

    Science.gov (United States)

    2010-01-01

    ...-Cured Tobacco (u.s. Types 22, 23, and Foreign Type 96) § 29.2515 Elasticity. The flexible, springy... 7 Agriculture 2 2010-01-01 2010-01-01 false Elasticity. 29.2515 Section 29.2515 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing...

  18. 7 CFR 29.3516 - Elasticity.

    Science.gov (United States)

    2010-01-01

    ... INSPECTION Standards Official Standard Grades for Dark Air-Cured Tobacco (u.s. Types 35, 36, 37 and Foreign Type 95) § 29.3516 Elasticity. The flexible, springy nature of the tobacco leaf to recover... 7 Agriculture 2 2010-01-01 2010-01-01 false Elasticity. 29.3516 Section 29.3516 Agriculture...

  19. 7 CFR 29.1014 - Elasticity.

    Science.gov (United States)

    2010-01-01

    ... INSPECTION Standards Official Standard Grades for Flue-Cured Tobacco (u.s. Types 11, 12, 13, 14 and Foreign Type 92) § 29.1014 Elasticity. The flexible, springy nature of the tobacco leaf to recover... 7 Agriculture 2 2010-01-01 2010-01-01 false Elasticity. 29.1014 Section 29.1014 Agriculture...

  20. 7 CFR 29.2265 - Elasticity.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Elasticity. 29.2265 Section 29.2265 Agriculture... INSPECTION Standards Official Standard Grades for Virginia Fire-Cured Tobacco (u.s. Type 21) § 29.2265 Elasticity. The flexible, springy nature of the tobacco leaf to recover approximately its original size and...

  1. Elastic least-squares reverse time migration

    KAUST Repository

    Feng, Zongcai

    2017-03-08

    We use elastic least-squares reverse time migration (LSRTM) to invert for the reflectivity images of P- and S-wave impedances. Elastic LSRTMsolves the linearized elastic-wave equations for forward modeling and the adjoint equations for backpropagating the residual wavefield at each iteration. Numerical tests on synthetic data and field data reveal the advantages of elastic LSRTM over elastic reverse time migration (RTM) and acoustic LSRTM. For our examples, the elastic LSRTM images have better resolution and amplitude balancing, fewer artifacts, and less crosstalk compared with the elastic RTM images. The images are also better focused and have better reflector continuity for steeply dipping events compared to the acoustic LSRTM images. Similar to conventional leastsquares migration, elastic LSRTM also requires an accurate estimation of the P- and S-wave migration velocity models. However, the problem remains that, when there are moderate errors in the velocity model and strong multiples, LSRTMwill produce migration noise stronger than that seen in the RTM images.

  2. Modelling the elastic properties of cellulose nanopaper

    DEFF Research Database (Denmark)

    Mao, Rui; Goutianos, Stergios; Tu, Wei

    2017-01-01

    The elastic modulus of cellulose nanopaper was predicted using a two-dimensional (2D) micromechanical fibrous network model. The elastic modulus predicted by the network model was 12 GPa, which is well within the range of experimental data for cellulose nanopapers. The stress state in the network...

  3. Elastic least-squares reverse time migration

    KAUST Repository

    Feng, Zongcai; Schuster, Gerard T.

    2017-01-01

    We use elastic least-squares reverse time migration (LSRTM) to invert for the reflectivity images of P- and S-wave impedances. Elastic LSRTMsolves the linearized elastic-wave equations for forward modeling and the adjoint equations for backpropagating the residual wavefield at each iteration. Numerical tests on synthetic data and field data reveal the advantages of elastic LSRTM over elastic reverse time migration (RTM) and acoustic LSRTM. For our examples, the elastic LSRTM images have better resolution and amplitude balancing, fewer artifacts, and less crosstalk compared with the elastic RTM images. The images are also better focused and have better reflector continuity for steeply dipping events compared to the acoustic LSRTM images. Similar to conventional leastsquares migration, elastic LSRTM also requires an accurate estimation of the P- and S-wave migration velocity models. However, the problem remains that, when there are moderate errors in the velocity model and strong multiples, LSRTMwill produce migration noise stronger than that seen in the RTM images.

  4. Intensity-based hierarchical elastic registration using approximating splines.

    Science.gov (United States)

    Serifovic-Trbalic, Amira; Demirovic, Damir; Cattin, Philippe C

    2014-01-01

    We introduce a new hierarchical approach for elastic medical image registration using approximating splines. In order to obtain the dense deformation field, we employ Gaussian elastic body splines (GEBS) that incorporate anisotropic landmark errors and rotation information. Since the GEBS approach is based on a physical model in form of analytical solutions of the Navier equation, it can very well cope with the local as well as global deformations present in the images by varying the standard deviation of the Gaussian forces. The proposed GEBS approximating model is integrated into the elastic hierarchical image registration framework, which decomposes a nonrigid registration problem into numerous local rigid transformations. The approximating GEBS registration scheme incorporates anisotropic landmark errors as well as rotation information. The anisotropic landmark localization uncertainties can be estimated directly from the image data, and in this case, they represent the minimal stochastic localization error, i.e., the Cramér-Rao bound. The rotation information of each landmark obtained from the hierarchical procedure is transposed in an additional angular landmark, doubling the number of landmarks in the GEBS model. The modified hierarchical registration using the approximating GEBS model is applied to register 161 image pairs from a digital mammogram database. The obtained results are very encouraging, and the proposed approach significantly improved all registrations comparing the mean-square error in relation to approximating TPS with the rotation information. On artificially deformed breast images, the newly proposed method performed better than the state-of-the-art registration algorithm introduced by Rueckert et al. (IEEE Trans Med Imaging 18:712-721, 1999). The average error per breast tissue pixel was less than 2.23 pixels compared to 2.46 pixels for Rueckert's method. The proposed hierarchical elastic image registration approach incorporates the GEBS

  5. Detection of gastrointestinal cancer by elastic scattering and absorption spectroscopies with the Los Alamos Optical Biopsy System

    Energy Technology Data Exchange (ETDEWEB)

    Mourant, J.R.; Boyer, J.; Johnson, T.M.; Lacey, J.; Bigio, I.J. [Los Alamos National Lab., NM (United States); Bohorfoush, A. [Wisconsin Medical School, Milwaukee, WI (United States). Dept. of Gastroenterology; Mellow, M. [Univ. of Oklahoma Medical School, Oklahoma City, OK (United States). Dept. of Gastroenterology

    1995-03-01

    The Los Alamos National Laboratory has continued the development of the Optical Biopsy System (OBS) for noninvasive, real-time in situ diagnosis of tissue pathologies. In proceedings of earlier SPIE conferences we reported on clinical measurements in the bladder, and we report here on recent results of clinical tests in the gastrointestinal tract. With the OBS, tissue pathologies are detected/diagnosed using spectral measurements of the elastic optical transport properties (scattering and absorption) of the tissue over a wide range of wavelengths. The use of elastic scattering as the key to optical tissue diagnostics in the OBS is based on the fact that many tissue pathologies, including a majority of cancer forms, exhibit significant architectural changes at the cellular and sub-cellular level. Since the cellular components that cause elastic scattering have dimensions typically on the order of visible to near-IR wavelengths, the elastic (Mie) scattering properties will be wavelength dependent. Thus, morphology and size changes can be expected to cause significant changes m an optical signature that is derived from the wavelength-dependence of elastic scattering. Additionally, the optical geometry of the OBS beneficially enhances its sensitivity for measuring absorption bands. The OBS employs a small fiber-optic probe that is amenable to use with any endoscope or catheter, or to direct surface examination, as well as interstitial needle insertion. Data acquistion/display time is <1 second.

  6. Tissue types (image)

    Science.gov (United States)

    ... are 4 basic types of tissue: connective tissue, epithelial tissue, muscle tissue, and nervous tissue. Connective tissue supports ... binds them together (bone, blood, and lymph tissues). Epithelial tissue provides a covering (skin, the linings of the ...

  7. Forest biomass and Armington elasticities in Europe

    International Nuclear Information System (INIS)

    Lundmark, Robert; Shahrammehr, Shima

    2011-01-01

    The purpose of this paper is to provide estimated Armington elasticities for selected European countries and for three forest biomass commodities of main interest in many energy models: roundwood, chips and particles and wood residues. The Armington elasticity is based on the assumption that a specific forest biomass commodity is differentiated by its origin. The statistically significant estimated Armington elasticities range from 0.52 for roundwood in Hungary to approximately 4.53 for roundwood in Estonia. On average, the statistically significant Armington elasticity for chips and particles over all countries is 1.7 and for wood residues and roundwood 1.3 and 1.5, respectively. These elasticities can provide benchmark values for simulation models trying to assess trade patterns of forest biomass commodities and energy policy effects for European countries or for the EU as a whole.

  8. Elasticity of Substitution and Antidumping Measures

    DEFF Research Database (Denmark)

    Drud Hansen, Jørgen; Meinen, Philipp; Nielsen, Jørgen Ulff-Møller

    Abstract This paper analyzes the role of the elasticity of substitution for anti-dumping decisions across countries. In monopolistic competition models with cost heterogeneous firms across countries, price differences vary inversely with the elasticity of substitution. Anti-dumping duties should...... therefore also vary inversely with the elasticity of substitution at least for countries which have a strong focus on prices in the determination of their anti-dumping measures. We test this for ten countries from 1990 to 2009 using data on anti-dumping from Chad Bown (2010) and US-data at 8-digit level...... in our empirical investigation support the predicted role of the elasticity of substitution as we find a significant negative relation between the elasticity of substitution and the final anti-dumping duties for the ‘lesser duty rule’ group of countries. The countries which do not follow the ‘lesser duty...

  9. Measuring the elasticity of plant cells with atomic force microscopy.

    Science.gov (United States)

    Braybrook, Siobhan A

    2015-01-01

    The physical properties of biological materials impact their functions. This is most evident in plants where the cell wall contains each cell's contents and connects each cell to its neighbors irreversibly. Examining the physical properties of the plant cell wall is key to understanding how plant cells, tissues, and organs grow and gain the shapes important for their respective functions. Here, we present an atomic force microscopy-based nanoindentation method for examining the elasticity of plant cells at the subcellular, cellular, and tissue level. We describe the important areas of experimental design to be considered when planning and executing these types of experiments and provide example data as illustration. Copyright © 2015 Elsevier Inc. All rights reserved.

  10. Calculation of elastic-plastic strain ranges for fatigue analysis based on linear elastic stresses

    International Nuclear Information System (INIS)

    Sauer, G.

    1998-01-01

    Fatigue analysis requires that the maximum strain ranges be known. These strain ranges are generally computed from linear elastic analysis. The elastic strain ranges are enhanced by a factor K e to obtain the total elastic-plastic strain range. The reliability of the fatigue analysis depends on the quality of this factor. Formulae for calculating the K e factor are proposed. A beam is introduced as a computational model for determining the elastic-plastic strains. The beam is loaded by the elastic stresses of the real structure. The elastic-plastic strains of the beam are compared with the beam's elastic strains. This comparison furnishes explicit expressions for the K e factor. The K e factor is tested by means of seven examples. (orig.)

  11. Size-dependent elastic/inelastic behavior of enamel over millimeter and nanometer length scales.

    Science.gov (United States)

    Ang, Siang Fung; Bortel, Emely L; Swain, Michael V; Klocke, Arndt; Schneider, Gerold A

    2010-03-01

    The microstructure of enamel like most biological tissues has a hierarchical structure which determines their mechanical behavior. However, current studies of the mechanical behavior of enamel lack a systematic investigation of these hierarchical length scales. In this study, we performed macroscopic uni-axial compression tests and the spherical indentation with different indenter radii to probe enamel's elastic/inelastic transition over four hierarchical length scales, namely: 'bulk enamel' (mm), 'multiple-rod' (10's microm), 'intra-rod' (100's nm with multiple crystallites) and finally 'single-crystallite' (10's nm with an area of approximately one hydroxyapatite crystallite). The enamel's elastic/inelastic transitions were observed at 0.4-17 GPa depending on the length scale and were compared with the values of synthetic hydroxyapatite crystallites. The elastic limit of a material is important as it provides insights into the deformability of the material before fracture. At the smallest investigated length scale (contact radius approximately 20 nm), elastic limit is followed by plastic deformation. At the largest investigated length scale (contact size approximately 2 mm), only elastic then micro-crack induced response was observed. A map of elastic/inelastic regions of enamel from millimeter to nanometer length scale is presented. Possible underlying mechanisms are also discussed. (c) 2009 Elsevier Ltd. All rights reserved.

  12. How can cells sense the elasticity of a substrate? An analysis using a cell tensegrity model

    Directory of Open Access Journals (Sweden)

    G De Santis

    2011-10-01

    Full Text Available A eukaryotic cell attaches and spreads on substrates, whether it is the extracellular matrix naturally produced by the cell itself, or artificial materials, such as tissue-engineered scaffolds. Attachment and spreading require the cell to apply forces in the nN range to the substrate via adhesion sites, and these forces are balanced by the elastic response of the substrate. This mechanical interaction is one determinant of cell morphology and, ultimately, cell phenotype. In this paper we use a finite element model of a cell, with a tensegrity structure to model the cytoskeleton of actin filaments and microtubules, to explore the way cells sense the stiffness of the substrate and thereby adapt to it. To support the computational results, an analytical 1D model is developed for comparison. We find that (i the tensegrity hypothesis of the cytoskeleton is sufficient to explain the matrix-elasticity sensing, (ii cell sensitivity is not constant but has a bell-shaped distribution over the physiological matrix-elasticity range, and (iii the position of the sensitivity peak over the matrix-elasticity range depends on the cytoskeletal structure and in particular on the F-actin organisation. Our model suggests that F-actin reorganisation observed in mesenchymal stem cells (MSCs in response to change of matrix elasticity is a structural-remodelling process that shifts the sensitivity peak towards the new value of matrix elasticity. This finding discloses a potential regulatory role of scaffold stiffness for cell differentiation.

  13. New empirical generalizations on the determinants of price elasticity

    NARCIS (Netherlands)

    Bijmolt, THA; Van Heerde, HJ; Pieters, RGM

    The importance of pricing decisions for firms has fueled an extensive stream of research on price elasticities. In an influential meta-analytical study, Tellis (1988) summarized price elasticity research findings until 1986. However, empirical generalizations on price elasticity require

  14. The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability

    Science.gov (United States)

    Bader, Kenneth B.

    2018-05-01

    Histotripsy is a form of therapeutic ultrasound that liquefies tissue mechanically via acoustic cavitation. Bubble expansion is paramount in the efficacy of histotripsy therapy, and the cavitation dynamics are strongly influenced by the medium elasticity. In this study, an analytic model to predict histotripsy-induced bubble expansion in a fluid was extended to include the effects of medium elasticity. Good agreement was observed between the predictions of the analytic model and numerical computations utilizing highly nonlinear excitations (shock-scattering histotripsy) and purely tensile pulses (microtripsy). No bubble expansion was computed for either form of histotripsy when the elastic modulus was greater than 20 MPa and the peak negative pressure was less than 50 MPa. Strain in the medium due to the expansion of a single bubble was also tabulated. The viability of red blood cells was calculated as a function of distance from the bubble wall based on empirical data of impulsive stretching of erythrocytes. Red blood cells remained viable at distances further than 44 µm from the bubble wall. As the medium elasticity increased, the distance over which bubble expansion-induced strain influenced red blood cells was found to decrease sigmoidally. These results highlight the relationship between tissue elasticity and the efficacy of histotripsy. In addition, an upper medium elasticity limit was identified, above which histotripsy may not be effective for tissue liquefaction.

  15. Measurement of tissue viscoelasticity with ultrasound

    Science.gov (United States)

    Greenleaf, J. F.; Alizad, A.

    2017-02-01

    Tissue properties such as elasticity and viscosity have been shown to be related to such tissue conditions as contraction, edema, fibrosis, and fat content among others. Magnetic Resonance Elastography has shown outstanding ability to measure the elasticity and in some cases the viscosity of tissues, especially in the liver, providing the ability to stage fibrotic liver disease similarly to biopsy. We discuss ultrasound methods of measuring elasticity and viscosity in tissues. Many of these methods are becoming widely available in the extant ultrasound machines distributed throughout the world. Some of the methods to be discussed are in the developmental stage. The advantages of the ultrasound methods are that the imaging instruments are widely available and that many of the viscoelastic measurements can be made during a short addition to the normal ultrasound examination time. In addition, the measurements can be made by ultrasound repetitively and quickly allowing evaluation of dynamic physiologic function in circumstances such as muscle contraction or artery relaxation. Measurement of viscoelastic tissue mechanical properties will become a consistent part of clinical ultrasound examinations in our opinion.

  16. The impact of decongestive physical therapy and elastic bandaging on the control of pain in patients with venous ulcers

    Directory of Open Access Journals (Sweden)

    GERALDO MAGELA SALOMÉ

    2018-03-01

    Full Text Available ABSTRACT Objective: to evaluate pain in individuals with venous ulcers treated with elastic bandage and decongestant physical therapy. Methods: we studied 90 patients, divided into three groups with 30 patients each: a group treated with elastic bandage and decongestant physical therapy; a group treated with elastic bandage; and a group treated only with primary dressing according to tissue type and presence of exudate. We used the Pain Numerical Scale to quantify pain intensity and the McGill Pain Questionnaire for pain qualitative assessment. Results: in the first evaluation, all patients who participated in the study reported intense pain. In the fifth evaluation, the majority of patients treated with elastic bandaging and decongestant physical therapy did not report pain; the majority of patients in the elastic bandage group reported mild pain; and most patients treated only with primary dressing reported mild to moderate pain. During all five assessments using the McGill questionnaire, most patients in the elastic bandaging and primary dressing groups used descriptors of the sensory, affective, evaluative and miscellaneous groups to describe their pain. However, in the fourth and fifth evaluations, most patients who received decongestant physical therapy combined with elastic bandaging treatment did not use any of the descriptors. Conclusion: patients treated with decongestant physical therapy and elastic bandage presented pain improvement from the third evaluation performed on.

  17. Elastic metamaterial beam with remotely tunable stiffness

    Energy Technology Data Exchange (ETDEWEB)

    Qian, Wei [University of Michigan–Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240 (China); Yu, Zhengyue [School of Naval Architecture, Ocean & Civil Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China); Wang, Xiaole [School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240 (China); Lai, Yun [College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215006 (China); Yellen, Benjamin B., E-mail: yellen@duke.edu [University of Michigan–Shanghai Jiao Tong University Joint Institute, Shanghai Jiao Tong University, Shanghai 200240 (China); Department of Mechanical Engineering and Materials Science, Duke University, P.O. Box 90300, Hudson Hall, Durham, North Carolina 27708 (United States)

    2016-02-07

    We demonstrate a dynamically tunable elastic metamaterial, which employs remote magnetic force to adjust its vibration absorption properties. The 1D metamaterial is constructed from a flat aluminum beam milled with a linear array of cylindrical holes. The beam is backed by a thin elastic membrane, on which thin disk-shaped permanent magnets are mounted. When excited by a shaker, the beam motion is tracked by a Laser Doppler Vibrometer, which conducts point by point scanning of the vibrating element. Elastic waves are unable to propagate through the beam when the driving frequency excites the first elastic bending mode in the unit cell. At these frequencies, the effective mass density of the unit cell becomes negative, which induces an exponentially decaying evanescent wave. Due to the non-linear elastic properties of the membrane, the effective stiffness of the unit cell can be tuned with an external magnetic force from nearby solenoids. Measurements of the linear and cubic static stiffness terms of the membrane are in excellent agreement with experimental measurements of the bandgap shift as a function of the applied force. In this implementation, bandgap shifts by as much as 40% can be achieved with ∼30 mN of applied magnetic force. This structure has potential for extension in 2D and 3D, providing a general approach for building dynamically tunable elastic metamaterials for applications in lensing and guiding elastic waves.

  18. Microstructural evolution in inhomogeneous elastic media

    International Nuclear Information System (INIS)

    Jou, H.J.; Leo, P.H.; Lowengrub, J.S.

    1997-01-01

    We simulate the diffusional evolution of microstructures produced by solid state diffusional transformations in elastically stressed binary alloys in two dimensions. The microstructure consists of arbitrarily shaped precipitates embedded coherently in an infinite matrix. The precipitate and matrix are taken to be elastically isotropic, although they may have different elastic constants (elastically inhomogeneous). Both far-field applied strains and mismatch strains between the phases are considered. The diffusion and elastic fields are calculated using the boundary integral method, together with a small scale preconditioner to remove ill-conditioning. The precipitate-matrix interfaces are tracked using a nonstiff time updating method. The numerical method is spectrally accurate and efficient. Simulations of a single precipitate indicate that precipitate shapes depend strongly on the mass flux into the system as well as on the elastic fields. Growing shapes (positive mass flux) are dendritic while equilibrium shapes (zero mass flux) are squarish. Simulations of multiparticle systems show complicated interactions between precipitate morphology and the overall development of microstructure (i.e., precipitate alignment, translation, merging, and coarsening). In both single and multiple particle simulations, the details of the microstructural evolution depend strongly o the elastic inhomogeneity, misfit strain, and applied fields. 57 refs., 24 figs

  19. Elastic metamaterial beam with remotely tunable stiffness

    Science.gov (United States)

    Qian, Wei; Yu, Zhengyue; Wang, Xiaole; Lai, Yun; Yellen, Benjamin B.

    2016-02-01

    We demonstrate a dynamically tunable elastic metamaterial, which employs remote magnetic force to adjust its vibration absorption properties. The 1D metamaterial is constructed from a flat aluminum beam milled with a linear array of cylindrical holes. The beam is backed by a thin elastic membrane, on which thin disk-shaped permanent magnets are mounted. When excited by a shaker, the beam motion is tracked by a Laser Doppler Vibrometer, which conducts point by point scanning of the vibrating element. Elastic waves are unable to propagate through the beam when the driving frequency excites the first elastic bending mode in the unit cell. At these frequencies, the effective mass density of the unit cell becomes negative, which induces an exponentially decaying evanescent wave. Due to the non-linear elastic properties of the membrane, the effective stiffness of the unit cell can be tuned with an external magnetic force from nearby solenoids. Measurements of the linear and cubic static stiffness terms of the membrane are in excellent agreement with experimental measurements of the bandgap shift as a function of the applied force. In this implementation, bandgap shifts by as much as 40% can be achieved with ˜30 mN of applied magnetic force. This structure has potential for extension in 2D and 3D, providing a general approach for building dynamically tunable elastic metamaterials for applications in lensing and guiding elastic waves.

  20. Elastic/Inelastic Measurement Project

    International Nuclear Information System (INIS)

    Yates, Steven; Hicks, Sally; Vanhoy, Jeffrey; McEllistrem, Marcus

    2015-12-01

    The work scope involves the measurement of neutron scattering from natural sodium ( 23 Na) and two isotopes of iron, 56 Fe and 54 Fe. Angular distributions, i.e., differential cross sections, of the scattered neutrons will be measured for 5 to 10 incident neutron energies per year. The work of the first year concentrates on 23 Na, while the enriched iron samples are procured. Differential neutron scattering cross sections provide information to guide nuclear reaction model calculations in the low-@@energy (few MeV) fast-@@neutron region. This region lies just above the isolated resonance region, which in general is well studied; however, model calculations are difficult in this region because overlapping resonance structure is evident and direct nuclear reactions are becoming important. The standard optical model treatment exhibits good predictive ability for the wide-@@region average cross sections but cannot treat the overlapping resonance features. In addition, models that do predict the direct reaction component must be guided by measurements to describe correctly the strength of the direct component, e.g., @@ 2 must be known to describe the direct component of the scattering to the first excited state. Measurements of the elastic scattering differential cross sections guide the optical model calculations, while inelastic differential cross sections provide the crucial information for correctly describing the direct component. Activities occurring during the performance period are described.

  1. Elastic/Inelastic Measurement Project

    Energy Technology Data Exchange (ETDEWEB)

    Yates, Steven [Univ. of Kentucky, Lexington, KY (United States); Hicks, Sally [Univ. of Dallas, TX (United States); Vanhoy, Jeffrey [U.S. Naval Academy, Annapolis, MD (United States); McEllistrem, Marcus [Univ. of Kentucky, Lexington, KY (United States)

    2016-03-01

    The work scope involves the measurement of neutron scattering from natural sodium (23Na) and two isotopes of iron, 56Fe and 54Fe. Angular distributions, i.e., differential cross sections, of the scattered neutrons will be measured for 5 to 10 incident neutron energies per year. The work of the first year concentrates on 23Na, while the enriched iron samples are procured. Differential neutron scattering cross sections provide information to guide nuclear reaction model calculations in the low-­energy (few MeV) fast-­neutron region. This region lies just above the isolated resonance region, which in general is well studied; however, model calculations are difficult in this region because overlapping resonance structure is evident and direct nuclear reactions are becoming important. The standard optical model treatment exhibits good predictive ability for the wide-­region average cross sections but cannot treat the overlapping resonance features. In addition, models that do predict the direct reaction component must be guided by measurements to describe correctly the strength of the direct component, e.g., β2 must be known to describe the direct component of the scattering to the first excited state. Measurements of the elastic scattering differential cross sections guide the optical model calculations, while inelastic differential cross sections provide the crucial information for correctly describing the direct component. Activities occurring during the performance period are described.

  2. SIMULATION OFTHERMO-ELASTICS PROPERTIESOFTHERMALBARRIERCOATINGS

    Directory of Open Access Journals (Sweden)

    A.M.Ferouani M. Ferouani

    2015-07-01

    Full Text Available Thermal barrier coatings are used to protect different parts in compressors and turbines from heat. They are generally composed of two layers, one metallic layer providing resistance to heat corrosion and oxidation, and one thermally insulating ceramic layer. Two different techniques are industrially used. Plasma spray results in a lamellar structure granting a low thermal conductivity, but with a low thermal expansion compliance. Electron Beam Physical Vapour Deposition generates a columnar structure allowing a better accommodation of the thermal expansion stresses, entailing improved lifetime of the coating, but with a higher thermal conductivity. The aim of the paper presented here is to develop a procedure of analysis based on the micro structural observation for the prediction of the properties of new coatings in court of industrial development and to predict the effect of the posterior thermal treatment on the properties of the coatings carried out. For a given coating, one has to calculate linear elasticity and its evolution with the temperature as well as thermal expansion, aiming at predicting different parameters related to the in service deterioration.  

  3. Microfluidic Platform for the Elastic Characterization of Mouse Submandibular Glands by Atomic Force Microscopy

    Directory of Open Access Journals (Sweden)

    Aaron P. Mosier

    2014-02-01

    Full Text Available The ability to characterize the microscale mechanical properties of biological materials has the potential for great utility in the field of tissue engineering. The development and morphogenesis of mammalian tissues are known to be guided in part by mechanical stimuli received from the local environment, and tissues frequently develop to match the physical characteristics (i.e., elasticity of their environment. Quantification of these material properties at the microscale may provide valuable information to guide researchers. Presented here is a microfluidic platform for the non-destructive ex vivo microscale mechanical characterization of mammalian tissue samples by atomic force microscopy (AFM. The device was designed to physically hold a tissue sample in a dynamically controllable fluid environment while allowing access by an AFM probe operating in force spectroscopy mode to perform mechanical testing. Results of measurements performed on mouse submandibular gland samples demonstrate the ability of the analysis platform to quantify sample elasticity at the microscale, and observe chemically-induced changes in elasticity.

  4. Muscle-tendon interaction and elastic energy usage in human walking

    DEFF Research Database (Denmark)

    Ishikawa, Masaki; Komi, Paavo V.; Grey, Michael James

    2005-01-01

    The present study was designed to explore how the interaction between the fascicles and tendinous tissues is involved in storage and utilization of elastic energy during human walking. Eight male subjects walked with a natural cadence (1.4 +/- 0.1 m/s) on a 10-m-long force plate system. In vivo......-stance phase. In contrast, the soleus fascicles were lengthened until the end of the single-stance phase. These findings suggest that the elastic recoil takes place not as a spring-like bouncing but as a catapult action in natural human walking. The interaction between the muscle fascicles and tendinous...

  5. Tissue Classification

    DEFF Research Database (Denmark)

    Van Leemput, Koen; Puonti, Oula

    2015-01-01

    Computational methods for automatically segmenting magnetic resonance images of the brain have seen tremendous advances in recent years. So-called tissue classification techniques, aimed at extracting the three main brain tissue classes (white matter, gray matter, and cerebrospinal fluid), are now...... well established. In their simplest form, these methods classify voxels independently based on their intensity alone, although much more sophisticated models are typically used in practice. This article aims to give an overview of often-used computational techniques for brain tissue classification...

  6. Marangoni elasticity of flowing soap films

    OpenAIRE

    Kim, Ildoo; Mandre, Shreyas

    2016-01-01

    We measure the Marangoni elasticity of a flowing soap film to be 22 dyne/cm irrespective of its width, thickness, flow speed, or the bulk soap concentration. We perform this measurement by generating an oblique shock in the soap film and measuring the shock angle, flow speed and thickness. We postulate that the elasticity is constant because the film surface is crowded with soap molecules. Our method allows non-destructive measurement of flowing soap film elasticity, and the value 22 dyne/cm ...

  7. Demand Elasticity on the Transport Market

    OpenAIRE

    Teodor Perić; Nada Štrumberger

    2002-01-01

    The elasticity of demand for traffic se1vices is the adaptationof traffic supply to traffic demand. The elasticity of suchdemand is low which is specific of the transport market, especiallyfrom the aspect of designing traffic demand.The essence of the problem of low elasticity can be noticedin three basic properties:First, in the change of place which determines the traffic demandor traffic relation.Second is the continuity of the need to transport goods andpassengers.Third, the needs for tra...

  8. Application Service Program (ASP) Price Elasticities

    OpenAIRE

    Hong Jaeweon; Cho Wanwoo; Jang Ho; Kwak Youngsik

    2010-01-01

    Although the price elasticities for off-line industry are well documented in academic field, the report of price elasticities for on-line to a given brand or industry in practice have beenrelatively rare. The researcher aims to try to full this gap by applying a price response function to Home Trading System’s on-line transaction data for the first time in Korean securities market. The different price elasticities among seven brands were found from -0.819 to -1.811. These results suggested th...

  9. Elastic and inelastic psi production by muons

    International Nuclear Information System (INIS)

    Loken, S.C.

    1981-06-01

    Results are presented on the elastic and inelastic production of psi (3.1). The elastic data are qualitative agreement with the predictions of photon-gluon fusion but have a steeper dependence on Q 2 than the model predicts. A QCD calculation accounts well for the shape of the inelastic data in inelasticity, Q 2 and E/sub γ/, but fails to account for the absolute cross section. At 209 GeV, the cross-section for elastic psi production is 0.36 +- 0.07 nb; for inelastic, 0.28 +- 0.06nb

  10. Marangoni elasticity of flowing soap films

    Science.gov (United States)

    Kim, Ildoo; Mandre, Shreyas

    2017-08-01

    We measure the Marangoni elasticity of a flowing soap film to be 22 mN/m irrespective of its width, thickness, flow speed, or the bulk soap concentration. We perform this measurement by generating an oblique shock in the soap film and measuring the shock angle, flow speed, and thickness. We postulate that the elasticity is constant because the film surface is crowded with soap molecules. Our method allows nondestructive measurement of flowing soap film elasticity and the value 22 mN/m is likely applicable to other similarly constructed flowing soap films.

  11. Elastic and piezoelectric fields around a quantum wire of zincblende heterostructures with interface elasticity effect

    Science.gov (United States)

    Ye, Wei; Liu, Yifei

    2018-04-01

    This work formulates the solutions to the elastic and piezoelectric fields around a quantum wire (QWR) with interface elasticity effect. Closed-form solutions to the piezoelectric potential field of zincblende QWR/matrix heterostructures grown along [111] crystallographic orientation are found and numerical results of InAs/InP heterostructures are provided as an example. The piezoelectric potential in the matrix depends on the interface elasticity, the radius and stiffness of the QWR. Our results indicate that interface elasticity can significantly alter the elastic and piezoelectric fields near the interface. Additionally, when the elastic property of the QWR is considered to be anisotropic in contrary to the common isotropic assumption, piezoelectric potentials are found to be distinct near the interface, but the deviations are negligible at positions far away from the interface.

  12. ELASTIC CHARACTERIZATION OF Eucalyptus citriodora WOOD

    Directory of Open Access Journals (Sweden)

    Adriano Wagner Ballarin

    2003-01-01

    Full Text Available This paper contributed to the elastic characterization of Eucalyptus citriodora grown inBrazil, considering an orthotropic model and evaluating its most important elastic constants.Considering this as a reference work to establish basic elastic ratios — several important elasticconstants of Brazilian woods were not determined yet - the experimental set-up utilized one tree of 65years old from plantations of “Horto Florestal Navarro de Andrade”, at Rio Claro-SP, Brazil. All theexperimental procedures attended NBR 7190/97 – Brazilian Code for wooden structures –withconventional tension and compression tests. Results showed statistical identity between compressionand tension modulus of elasticity. The relation observed between longitudinal and radial modulus ofelasticity was 10 (EL/ER ≈ 10 and same relation, considering shear modulus (modulus of rigidity was20 (EL/GLR ≈ 20. These results, associated with Poisson’s ratios herein determined, allow theoreticalmodeling of wood mechanical behavior in structures.

  13. Demand Elasticity on the Transport Market

    Directory of Open Access Journals (Sweden)

    Teodor Perić

    2002-09-01

    Full Text Available The elasticity of demand for traffic se1vices is the adaptationof traffic supply to traffic demand. The elasticity of suchdemand is low which is specific of the transport market, especiallyfrom the aspect of designing traffic demand.The essence of the problem of low elasticity can be noticedin three basic properties:First, in the change of place which determines the traffic demandor traffic relation.Second is the continuity of the need to transport goods andpassengers.Third, the needs for transport may vmy according to thechanges in society and economy, and they also change thesources of traffic demand. Therefore, the elasticity of demandfor traffic se1vices is relatively low.

  14. Elastic reflection waveform inversion with variable density

    KAUST Repository

    Li, Yuanyuan; Li, Zhenchun; Alkhalifah, Tariq Ali; Guo, Qiang

    2017-01-01

    Elastic full waveform inversion (FWI) provides a better description of the subsurface than those given by the acoustic assumption. However it suffers from a more serious cycle skipping problem compared with the latter. Reflection waveform inversion

  15. Elastic scattering of slow positrons by helium

    International Nuclear Information System (INIS)

    Amusia, M.Ya.; Cherepkov, N.A.; Chernysheva, L.V.; Shapiro, S.G.

    1976-01-01

    The s-, p-, d- and f-wave phaseshifts for elastic scattering of slow positrons by He are calculated using a simplified version of the random phase approximation with exchange, with virtual positronium formation effect taken into account. (author)

  16. Elastic and Anelastic Structure Beneath Eurasia

    National Research Council Canada - National Science Library

    Ekstrom, Goran

    1997-01-01

    The primary objective of this work has been to map the variations of elastic mantle properties beneath Eurasia over horizontal length scales of approximately 1000-1500 kilometers and vertial length...

  17. Elastic and inelastic heavy ion scattering

    International Nuclear Information System (INIS)

    Toepffer, C.; University of the Witwatersrand, Johannesburg; Richter, A.

    1977-02-01

    In the field of elastic and inelastic heavy ion scattering, the following issues are dealt with: semiclassical descriptive approximations, optical potentials, barriers, critical radii and angular momenta, excitation functions and the application to superheavy ions and high energies. (WL) [de

  18. Elastic spheres can walk on water.

    Science.gov (United States)

    Belden, Jesse; Hurd, Randy C; Jandron, Michael A; Bower, Allan F; Truscott, Tadd T

    2016-02-04

    Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water impact physics. Here we show that upon water impact, very compliant spheres naturally assume a disk-like geometry and dynamic orientation that are favourable for water-skipping. Experiments and numerical modelling reveal that the initial spherical shape evolves as elastic waves propagate through the material. We find that the skipping dynamics are governed by the wave propagation speed and by the ratio of material shear modulus to hydrodynamic pressure. With these insights, we explain why softer spheres skip more easily than stiffer ones. Our results advance understanding of fluid-elastic body interaction during water impact, which could benefit inflatable craft modelling and, more playfully, design of elastic aquatic toys.

  19. Solitary waves on nonlinear elastic rods. I

    DEFF Research Database (Denmark)

    Sørensen, Mads Peter; Christiansen, Peter Leth; Lomdahl, P. S.

    1984-01-01

    Acoustic waves on elastic rods with circular cross section are governed by improved Boussinesq equations when transverse motion and nonlinearity in the elastic medium are taken into account. Solitary wave solutions to these equations have been found. The present paper treats the interaction betwe...... nonlinearity. The balance between dispersion and nonlinearity in the equation is investigated.......Acoustic waves on elastic rods with circular cross section are governed by improved Boussinesq equations when transverse motion and nonlinearity in the elastic medium are taken into account. Solitary wave solutions to these equations have been found. The present paper treats the interaction between...... the solitary waves numerically. It is demonstrated that the waves behave almost like solitons in agreement with the fact that the improved Boussinesq equations are nearly integrable. Thus three conservation theorems can be derived from the equations. A new subsonic quasibreather is found in the case of a cubic...

  20. Multimodality instrument for tissue characterization

    Science.gov (United States)

    Mah, Robert W. (Inventor); Andrews, Russell J. (Inventor)

    2004-01-01

    A system with multimodality instrument for tissue identification includes a computer-controlled motor driven heuristic probe with a multisensory tip. For neurosurgical applications, the instrument is mounted on a stereotactic frame for the probe to penetrate the brain in a precisely controlled fashion. The resistance of the brain tissue being penetrated is continually monitored by a miniaturized strain gauge attached to the probe tip. Other modality sensors may be mounted near the probe tip to provide real-time tissue characterizations and the ability to detect the proximity of blood vessels, thus eliminating errors normally associated with registration of pre-operative scans, tissue swelling, elastic tissue deformation, human judgement, etc., and rendering surgical procedures safer, more accurate, and efficient. A neural network program adaptively learns the information on resistance and other characteristic features of normal brain tissue during the surgery and provides near real-time modeling. A fuzzy logic interface to the neural network program incorporates expert medical knowledge in the learning process. Identification of abnormal brain tissue is determined by the detection of change and comparison with previously learned models of abnormal brain tissues. The operation of the instrument is controlled through a user friendly graphical interface. Patient data is presented in a 3D stereographics display. Acoustic feedback of selected information may optionally be provided. Upon detection of the close proximity to blood vessels or abnormal brain tissue, the computer-controlled motor immediately stops probe penetration. The use of this system will make surgical procedures safer, more accurate, and more efficient. Other applications of this system include the detection, prognosis and treatment of breast cancer, prostate cancer, spinal diseases, and use in general exploratory surgery.

  1. Elastic form factors at higher CEBAF energies

    Energy Technology Data Exchange (ETDEWEB)

    Petratos, G.G. [Kent State Univ., OH (United States)

    1994-04-01

    The prospects for elastic scattering from few body systems with higher beam energies at CEBAF is presented. The deuteron and{sup 3}He elastic structure functions A(Q{sup 2}) can be measured at sufficiently high momentum transfers to study the transition between the conventional meson-nucleon and the constituent quark-gluon descriptions. Possible improvements in the proton magnetic form factor data are also presented.

  2. Extremal Overall Elastic Response of Polycrystalline Materials

    DEFF Research Database (Denmark)

    Bendsøe, Martin P; Lipton, Robert

    1996-01-01

    Polycrystalline materials comprised of grains obtained froma single anisotropic material are considered in the frameworkof linear elasticity. No assumptions on the symmetry of thepolycrystal are made. We subject the material to independentexternal strain and stress fields with prescribed mean...... values.We show that the extremal overall elastic response is alwaysachieved by a configuration consisting of a single properlyoriented crystal. This result is compared to results for isotropicpolycrystals....

  3. Laboratory Tests of Bitumen Samples Elasticity

    Science.gov (United States)

    Ziganshin, E. R.; Usmanov, S. A.; Khasanov, D. I.; Khamidullina, G. S.

    2018-05-01

    This paper is devoted to the study of the elastic and acoustic properties of bitumen core samples. The travel velocities of the ultrasonic P- and S-waves were determined under in-situ simulation conditions. The resulting data were then used to calculate dynamic Young's modulus and Poisson's ratio. The authors studied the correlation between the elasticity and the permeability and porosity. In addition, the tests looked into how the acoustic properties had changed with temperature rise.

  4. On the use of elastic-plastic material characteristics for linear-elastic component assessments

    International Nuclear Information System (INIS)

    Kussmaul, K.; Silcher, H.; Eisele, U.

    1995-01-01

    In this paper the procedure of safety assessment of components by fracture mechanics analysis as recommended in TECDOC 717 is applied to two standard specimens of ductile cast iron. It is shown that the use of a pseudo-elastic K IJ -value in linear elastic safety analysis may lead to non-conservative results, when elastic-plastic material behaviour can be expected. (author)

  5. Positron interactions with water–total elastic, total inelastic, and elastic differential cross section measurements

    International Nuclear Information System (INIS)

    Tattersall, Wade; Chiari, Luca; Machacek, J. R.; Anderson, Emma; Sullivan, James P.; White, Ron D.; Brunger, M. J.; Buckman, Stephen J.; Garcia, Gustavo; Blanco, Francisco

    2014-01-01

    Utilising a high-resolution, trap-based positron beam, we have measured both elastic and inelastic scattering of positrons from water vapour. The measurements comprise differential elastic, total elastic, and total inelastic (not including positronium formation) absolute cross sections. The energy range investigated is from 1 eV to 60 eV. Comparison with theory is made with both R-Matrix and distorted wave calculations, and with our own application of the Independent Atom Model for positron interactions

  6. Elastic reflection waveform inversion with variable density

    KAUST Repository

    Li, Yuanyuan

    2017-08-17

    Elastic full waveform inversion (FWI) provides a better description of the subsurface than those given by the acoustic assumption. However it suffers from a more serious cycle skipping problem compared with the latter. Reflection waveform inversion (RWI) provides a method to build a good background model, which can serve as an initial model for elastic FWI. Therefore, we introduce the concept of RWI for elastic media, and propose elastic RWI with variable density. We apply Born modeling to generate the synthetic reflection data by using optimized perturbations of P- and S-wave velocities and density. The inversion for the perturbations in P- and S-wave velocities and density is similar to elastic least-squares reverse time migration (LSRTM). An incorrect initial model will lead to some misfits at the far offsets of reflections; thus, can be utilized to update the background velocity. We optimize the perturbation and background models in a nested approach. Numerical tests on the Marmousi model demonstrate that our method is able to build reasonably good background models for elastic FWI with absence of low frequencies, and it can deal with the variable density, which is needed in real cases.

  7. Income Elasticity Literature Review | Science Inventory | US ...

    Science.gov (United States)

    Following advice from the SAB Council, when estimating the economic value of reductions in air pollution-related mortality and morbidity risk, EPA accounts for the effect of personal income on the willingness to pay to reduce the risk of adverse health outcomes. These income growth adjustment factors are calculated using a combination of income elasticity estimates and income growth projections, both of which have remained essentially unchanged since 1999. These income elasticity estimates vary according to the severity of illness. EPA recently received advice from the SAB regarding the range of income elasticities to apply as well as the research standards to use when selecting income elasticity estimates. Following this advice, EPA consulted with a contractor to update its income elasticity and income growth projections, and generate new income growth adjustment factors. The SAB would evaluate the income elasticity estimates identified in the EPA-provided literature review, determining the extent to which these estimates are appropriate to use in human health benefits assessments.

  8. Elastic interactions between hydrogen atoms in metals. II. Elastic interaction energies

    International Nuclear Information System (INIS)

    Shirley, A.I.; Hall, C.K.

    1986-01-01

    The fully harmonic lattice approximation derived in a previous paper is used to calculate the elastic interaction energies in the niobium-hydrogen system. The permanent-direct, permanent-indirect, induced-direct, and induced-indirect forces calculated previously each give rise to a corresponding elastic interaction between hydrogen atoms. The latter three interactions have three- and four-body terms in addition to the usual two-body terms. These quantities are calculated and compared with the corresponding two-body permanent elastic interactions obtained in the harmonic-approximation treatment of Horner and Wagner. The results show that the total induced elastic energy is approximately (1/3) the size of the total permanent elastic energy and opposite to it in sign. The total elastic energy due to three-body interactions is approximately (1/4) the size of the total two-body elastic energy, while the total four-body elastic energy is approximately 5% of the total two-body energy. These additional elastic energies are expected to have a profound effect on the thermodynamic and phase-change behavior of a metal hydride

  9. Controlling elastic waves with small phononic crystals containing rigid inclusions

    KAUST Repository

    Peng, Pai; Qiu, Chunyin; Liu, Zhengyou; Wu, Ying

    2014-01-01

    waveguide made of a two-layer anisotropic elastic phononic crystal, which can guide and bend elastic waves with wavelengths much larger than the size of the waveguide. The other example is the enhanced elastic transmission of a single-layer elastic phononic

  10. THE ELASTICITY OF EXPORT DEMAND FOR US COTTON

    OpenAIRE

    Paudel, Laxmi; Houston, Jack E.; Adhikari, Murali; Devkota, Nirmala

    2004-01-01

    There exist conflicting views among the researchers about the magnitudes of US cotton export demand elasticity, ranging from the highly inelastic to highly elastic. An Armington model was used to analyze the export demand elasticity of US Cotton. Our analysis confirms an elastic nature of US cotton export demand.

  11. Elastic hydrogel substrate supports robust expansion of murine myoblasts and enhances their engraftment

    International Nuclear Information System (INIS)

    Ding, Ke; Yang, Zhong; Xu, Jian-zhong; Liu, Wen-ying; Zeng, Qiang; Hou, Fang; Lin, Sen

    2015-01-01

    The application of satellite cell-derived myoblasts in regenerative medicine has been restricted by the rapid loss of stemness during in vitro cell expansion using traditional culture systems. However, studies published in the past decade have highlighted the influence of substrate elasticity on stem cell fate and revealed that culture on a soft hydrogel substrate can promote self-renewal and prolong the regenerative potential of muscle stem cells. Whether hydrogel substrates have similar effects after long-term robust expansion remains to be determined. Herein we prepared an elastic chitosan/beta-glycerophosphate/collagen hydrogel mimicking the soft microenvironment of muscle tissues for use as the substrate for satellite cell culture and investigated its influence on long-term cell expansion. After 20 passages in culture, satellite cell-derived myoblasts cultured on our hydrogel substrate exhibited significant improvements in proliferation capability, cell viability, colony forming frequency, and potential for myogenic differentiation compared to those cultured on a routine rigid culture surface. Immunochemical staining and western blot analysis both confirmed that myoblasts cultured on the hydrogel substrate expressed higher levels of several differentiation-related markers, including Pax7, Pax3, and SSEA-1, and a lower level of MyoD compared to myoblasts cultured on rigid culture plates (all p<0.05). After transplantation into the tibialis anterior of nude mice, myoblasts that had been cultured on the hydrogel substrate demonstrated a significantly greater engraftment efficacy than those cultured on the traditional surface. Collectively, these results indicate that the elastic hydrogel substrate supported robust expansion of murine myoblasts and enhanced their engraftment in vivo. - Highlights: • An elastic hydrogel was designed to mimic the pliable muscle tissue microenvironment. • Myoblasts retained their stemness in long-term culture on the elastic

  12. Elastic hydrogel substrate supports robust expansion of murine myoblasts and enhances their engraftment

    Energy Technology Data Exchange (ETDEWEB)

    Ding, Ke, E-mail: dk1118@yeah.net [Department of Pediatric Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072 (China); Yang, Zhong [Department of Clinical Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China); Xu, Jian-zhong, E-mail: xjzspine@163.com [Department of Orthopaedics, Southwest Hospital, Third Military Medical University, Chongqing 400038 (China); Liu, Wen-ying; Zeng, Qiang; Hou, Fang [Department of Pediatric Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072 (China); Lin, Sen [Department of Anatomy and Histology & Embryology, Chengdu Medical College, Chengdu 610500 (China)

    2015-09-10

    The application of satellite cell-derived myoblasts in regenerative medicine has been restricted by the rapid loss of stemness during in vitro cell expansion using traditional culture systems. However, studies published in the past decade have highlighted the influence of substrate elasticity on stem cell fate and revealed that culture on a soft hydrogel substrate can promote self-renewal and prolong the regenerative potential of muscle stem cells. Whether hydrogel substrates have similar effects after long-term robust expansion remains to be determined. Herein we prepared an elastic chitosan/beta-glycerophosphate/collagen hydrogel mimicking the soft microenvironment of muscle tissues for use as the substrate for satellite cell culture and investigated its influence on long-term cell expansion. After 20 passages in culture, satellite cell-derived myoblasts cultured on our hydrogel substrate exhibited significant improvements in proliferation capability, cell viability, colony forming frequency, and potential for myogenic differentiation compared to those cultured on a routine rigid culture surface. Immunochemical staining and western blot analysis both confirmed that myoblasts cultured on the hydrogel substrate expressed higher levels of several differentiation-related markers, including Pax7, Pax3, and SSEA-1, and a lower level of MyoD compared to myoblasts cultured on rigid culture plates (all p<0.05). After transplantation into the tibialis anterior of nude mice, myoblasts that had been cultured on the hydrogel substrate demonstrated a significantly greater engraftment efficacy than those cultured on the traditional surface. Collectively, these results indicate that the elastic hydrogel substrate supported robust expansion of murine myoblasts and enhanced their engraftment in vivo. - Highlights: • An elastic hydrogel was designed to mimic the pliable muscle tissue microenvironment. • Myoblasts retained their stemness in long-term culture on the elastic

  13. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

    Energy Technology Data Exchange (ETDEWEB)

    Alcaraz, Jordi; Xu, Ren; Mori, Hidetoshi; Nelson, Celeste M.; Mroue, Rana; Spencer, Virginia A.; Brownfield, Doug; Radisky, Derek C.; Bustamante, Carlos; Bissell, Mina J.

    2008-10-20

    In the mammary gland, epithelial cells are embedded in a 'soft' environment and become functionally differentiated in culture when exposed to a laminin-rich extracellular matrix gel. Here, we define the processes by which mammary epithelial cells integrate biochemical and mechanical extracellular cues to maintain their differentiated phenotype. We used single cells cultured on top of gels in conditions permissive for {beta}-casein expression using atomic force microscopy to measure the elasticity of the cells and their underlying substrata. We found that maintenance of {beta}-casein expression required both laminin signalling and a 'soft' extracellular matrix, as is the case in normal tissues in vivo, and biomimetic intracellular elasticity, as is the case in primary mammary epithelial organoids. Conversely, two hallmarks of breast cancer development, stiffening of the extracellular matrix and loss of laminin signalling, led to the loss of {beta}-casein expression and non-biomimetic intracellular elasticity. Our data indicate that tissue-specific gene expression is controlled by both the tissues unique biochemical milieu and mechanical properties, processes involved in maintenance of tissue integrity and protection against tumorigenesis.

  14. Internal strain estimation for quantification of human heel pad elastic modulus: A phantom study.

    Science.gov (United States)

    Holst, Karen; Liebgott, Hervé; Wilhjelm, Jens E; Nikolov, Svetoslav; Torp-Pedersen, Søren T; Delachartre, Philippe; Jensen, Jørgen A

    2013-02-01

    Shock absorption is the most important function of the human heel pad. However, changes in heel pad elasticity, as seen in e.g. long-distance runners, diabetes patients, and victims of Falanga torture are affecting this function, often in a painful manner. Assessment of heel pad elasticity is usually based on one or a few strain measurements obtained by an external load-deformation system. The aim of this study was to develop a technique for quantitative measurements of heel pad elastic modulus based on several internal strain measures from within the heel pad by use of ultrasound images. Nine heel phantoms were manufactured featuring a combination of three heel pad stiffnesses and three heel pad thicknesses to model the normal human variation. Each phantom was tested in an indentation system comprising a 7MHz linear array ultrasound transducer, working as the indentor, and a connected load cell. Load-compression data and ultrasound B-mode images were simultaneously acquired in 19 compression steps of 0.1mm each. The internal tissue displacement was for each step calculated by a phase-based cross-correlation technique and internal strain maps were derived from these displacement maps. Elastic moduli were found from the resulting stress-strain curves. The elastic moduli made it possible to distinguish eight of nine phantoms from each other according to the manufactured stiffness and showed very little dependence of the thickness. Mean elastic moduli for the three soft, the three medium, and the three hard phantoms were 89kPa, 153kPa, and 168kPa, respectively. The combination of ultrasound images and force measurements provided an effective way of assessing the elastic properties of the heel pad due to the internal strain estimation. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Microstructure, elastic deformation behavior and mechanical properties of biomedical β-type titanium alloy thin-tube used for stents.

    Science.gov (United States)

    Tian, Yuxing; Yu, Zhentao; Ong, Chun Yee Aaron; Kent, Damon; Wang, Gui

    2015-05-01

    Cold-deformability and mechanical compatibility of the biomedical β-type titanium alloy are the foremost considerations for their application in stents, because the lower ductility restricts the cold-forming of thin-tube and unsatisfactory mechanical performance causes a failed tissue repair. In this paper, β-type titanium alloy (Ti-25Nb-3Zr-3Mo-2Sn, wt%) thin-tube fabricated by routine cold rolling is reported for the first time, and its elastic behavior and mechanical properties are discussed for the various microstructures. The as cold-rolled tube exhibits nonlinear elastic behavior with large recoverable strain of 2.3%. After annealing and aging, a nonlinear elasticity, considered as the intermediate stage between "double yielding" and normal linear elasticity, is attributable to a moderate precipitation of α phase. Quantitive relationships are established between volume fraction of α phase (Vα) and elastic modulus, strength as well as maximal recoverable strain (εmax-R), where the εmax-R of above 2.0% corresponds to the Vα range of 3-10%. It is considered that the "mechanical" stabilization of the (α+β) microstructure is a possible elastic mechanism for explaining the nonlinear elastic behavior. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Inverse methods for 3D quantitative optical coherence elasticity imaging (Conference Presentation)

    Science.gov (United States)

    Dong, Li; Wijesinghe, Philip; Hugenberg, Nicholas; Sampson, David D.; Munro, Peter R. T.; Kennedy, Brendan F.; Oberai, Assad A.

    2017-02-01

    In elastography, quantitative elastograms are desirable as they are system and operator independent. Such quantification also facilitates more accurate diagnosis, longitudinal studies and studies performed across multiple sites. In optical elastography (compression, surface-wave or shear-wave), quantitative elastograms are typically obtained by assuming some form of homogeneity. This simplifies data processing at the expense of smearing sharp transitions in elastic properties, and/or introducing artifacts in these regions. Recently, we proposed an inverse problem-based approach to compression OCE that does not assume homogeneity, and overcomes the drawbacks described above. In this approach, the difference between the measured and predicted displacement field is minimized by seeking the optimal distribution of elastic parameters. The predicted displacements and recovered elastic parameters together satisfy the constraint of the equations of equilibrium. This approach, which has been applied in two spatial dimensions assuming plane strain, has yielded accurate material property distributions. Here, we describe the extension of the inverse problem approach to three dimensions. In addition to the advantage of visualizing elastic properties in three dimensions, this extension eliminates the plane strain assumption and is therefore closer to the true physical state. It does, however, incur greater computational costs. We address this challenge through a modified adjoint problem, spatially adaptive grid resolution, and three-dimensional decomposition techniques. Through these techniques the inverse problem is solved on a typical desktop machine within a wall clock time of 20 hours. We present the details of the method and quantitative elasticity images of phantoms and tissue samples.

  17. Elastic cartilage reconstruction by transplantation of cultured hyaline cartilage-derived chondrocytes.

    Science.gov (United States)

    Mizuno, M; Takebe, T; Kobayashi, S; Kimura, S; Masutani, M; Lee, S; Jo, Y H; Lee, J I; Taniguchi, H

    2014-05-01

    Current surgical intervention of craniofacial defects caused by injuries or abnormalities uses reconstructive materials, such as autologous cartilage grafts. Transplantation of autologous tissues, however, places a significant invasiveness on patients, and many efforts have been made for establishing an alternative graft. Recently, we and others have shown the potential use of reconstructed elastic cartilage from ear-derived chondrocytes or progenitors with the unique elastic properties. Here, we examined the differentiation potential of canine joint cartilage-derived chondrocytes into elastic cartilage for expanding the cell sources, such as hyaline cartilage. Articular chondrocytes are isolated from canine joint, cultivated, and compared regarding characteristic differences with auricular chondrocytes, including proliferation rates, gene expression, extracellular matrix production, and cartilage reconstruction capability after transplantation. Canine articular chondrocytes proliferated less robustly than auricular chondrocytes, but there was no significant difference in the amount of sulfated glycosaminoglycan produced from redifferentiated chondrocytes. Furthermore, in vitro expanded and redifferentiated articular chondrocytes have been shown to reconstruct elastic cartilage on transplantation that has histologic characteristics distinct from hyaline cartilage. Taken together, cultured hyaline cartilage-derived chondrocytes are a possible cell source for elastic cartilage reconstruction. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  18. Systematic feasibility analysis of a quantitative elasticity estimation for breast anatomy using supine/prone patient postures.

    Science.gov (United States)

    Hasse, Katelyn; Neylon, John; Sheng, Ke; Santhanam, Anand P

    2016-03-01

    Breast elastography is a critical tool for improving the targeted radiotherapy treatment of breast tumors. Current breast radiotherapy imaging protocols only involve prone and supine CT scans. There is a lack of knowledge on the quantitative accuracy with which breast elasticity can be systematically measured using only prone and supine CT datasets. The purpose of this paper is to describe a quantitative elasticity estimation technique for breast anatomy using only these supine/prone patient postures. Using biomechanical, high-resolution breast geometry obtained from CT scans, a systematic assessment was performed in order to determine the feasibility of this methodology for clinically relevant elasticity distributions. A model-guided inverse analysis approach is presented in this paper. A graphics processing unit (GPU)-based linear elastic biomechanical model was employed as a forward model for the inverse analysis with the breast geometry in a prone position. The elasticity estimation was performed using a gradient-based iterative optimization scheme and a fast-simulated annealing (FSA) algorithm. Numerical studies were conducted to systematically analyze the feasibility of elasticity estimation. For simulating gravity-induced breast deformation, the breast geometry was anchored at its base, resembling the chest-wall/breast tissue interface. Ground-truth elasticity distributions were assigned to the model, representing tumor presence within breast tissue. Model geometry resolution was varied to estimate its influence on convergence of the system. A priori information was approximated and utilized to record the effect on time and accuracy of convergence. The role of the FSA process was also recorded. A novel error metric that combined elasticity and displacement error was used to quantify the systematic feasibility study. For the authors' purposes, convergence was set to be obtained when each voxel of tissue was within 1 mm of ground-truth deformation. The authors

  19. Is the Armington Elasticity Really Constant across Importers?

    OpenAIRE

    Yilmazkuday, Hakan

    2009-01-01

    This paper shows that the Armington elasticity, which refers to both the elasticity of substitution across goods and the price elasticity of demand under the assumption of a large number of varieties, systematically changes from one importer country to another in an international trade context. Then a natural question to ask is "What determines the Armington elasticity?" The answer comes from the distinction between the elasticity of demand with respect to the destination price (i.e., the Arm...

  20. Experimental determination of third-order elastic constants of diamond.

    Science.gov (United States)

    Lang, J M; Gupta, Y M

    2011-03-25

    To determine the nonlinear elastic response of diamond, single crystals were shock compressed along the [100], [110], and [111] orientations to 120 GPa peak elastic stresses. Particle velocity histories and elastic wave velocities were measured by using laser interferometry. The measured elastic wave profiles were used, in combination with published acoustic measurements, to determine the complete set of third-order elastic constants. These constants represent the first experimental determination, and several differ significantly from those calculated by using theoretical models.

  1. Vibration of an Elastic Circular Plate on an Elastic Half Space

    DEFF Research Database (Denmark)

    Krenk, Steen; Schmidt, H.

    1981-01-01

    The axisymmetric problem of a vibrating elastic plate on an elastic half space is solved by a direct method, in which the contact stresses and the normal displacements of the plate are taken as the unknown functions. First, the influence functions that give the displacements in terms...

  2. Asymmetric Vibrations of a Circular Elastic Plate on an Elastic Half Space

    DEFF Research Database (Denmark)

    Schmidt, H.; Krenk, Steen

    1982-01-01

    The asymmetric problem of a vibrating circular elastic plate in frictionless contact with an elastic half space is solved by an integral equation method, where the contact stress appears as the unknown function. By a trigonometric expansion, the problem is reduced to a number of uncoupled two...

  3. Elastic-plastic collapse of super-elastic shock waves in face-centered-cubic solids

    International Nuclear Information System (INIS)

    Zhakhovsky, Vasily V; Demaske, Brian J; Oleynik, Ivan I; Inogamov, Nail A; White, Carter T

    2014-01-01

    Shock waves in the [110] and [111] directions of single-crystal Al samples were studied using molecular dynamics (MD) simulations. Piston-driven simulations were performed to investigate the split shock-wave regime. At low piston velocities, the material is compressed initially to a metastable over-compressed elastic state leading to a super-elastic single shock wave. This metastable elastic state later collapses to a plastic state resulting in the formation of a two-wave structure consisting of an elastic precursor followed by a slower plastic wave. The single two-zone elastic-plastic shock-wave regime appearing at higher piston velocities was studied using moving window MD. The plastic wave attains the same average speed as the elastic precursor to form a single two-zone shock wave. In this case, repeated collapse of the highly over-compressed elastic state near the plastic shock front produces ultrashort triangle pulses that provide the pressure support for the leading elastic precursor.

  4. Equivalence between short-time biphasic and incompressible elastic material responses.

    Science.gov (United States)

    Ateshian, Gerard A; Ellis, Benjamin J; Weiss, Jeffrey A

    2007-06-01

    Porous-permeable tissues have often been modeled using porous media theories such as the biphasic theory. This study examines the equivalence of the short-time biphasic and incompressible elastic responses for arbitrary deformations and constitutive relations from first principles. This equivalence is illustrated in problems of unconfined compression of a disk, and of articular contact under finite deformation, using two different constitutive relations for the solid matrix of cartilage, one of which accounts for the large disparity observed between the tensile and compressive moduli in this tissue. Demonstrating this equivalence under general conditions provides a rationale for using available finite element codes for incompressible elastic materials as a practical substitute for biphasic analyses, so long as only the short-time biphasic response is sought. In practice, an incompressible elastic analysis is representative of a biphasic analysis over the short-term response deltatelasticity tensor, and K is the hydraulic permeability tensor of the solid matrix. Certain notes of caution are provided with regard to implementation issues, particularly when finite element formulations of incompressible elasticity employ an uncoupled strain energy function consisting of additive deviatoric and volumetric components.

  5. A family of hyperelastic models for human brain tissue

    Science.gov (United States)

    Mihai, L. Angela; Budday, Silvia; Holzapfel, Gerhard A.; Kuhl, Ellen; Goriely, Alain

    2017-09-01

    Experiments on brain samples under multiaxial loading have shown that human brain tissue is both extremely soft when compared to other biological tissues and characterized by a peculiar elastic response under combined shear and compression/tension: there is a significant increase in shear stress with increasing axial compression compared to a moderate increase with increasing axial tension. Recent studies have revealed that many widely used constitutive models for soft biological tissues fail to capture this characteristic response. Here, guided by experiments of human brain tissue, we develop a family of modeling approaches that capture the elasticity of brain tissue under varying simple shear superposed on varying axial stretch by exploiting key observations about the behavior of the nonlinear shear modulus, which can be obtained directly from the experimental data.

  6. Acoustic Radiation Force-Induced Creep-Recovery (ARFICR): A Noninvasive Method to Characterize Tissue Viscoelasticity.

    Science.gov (United States)

    Amador Carrascal, Carolina; Chen, Shigao; Urban, Matthew W; Greenleaf, James F

    2018-01-01

    Ultrasound shear wave elastography is a promising noninvasive, low cost, and clinically viable tool for liver fibrosis staging. Current shear wave imaging technologies on clinical ultrasound scanners ignore shear wave dispersion and use a single group velocity measured over the shear wave bandwidth to estimate tissue elasticity. The center frequency and bandwidth of shear waves induced by acoustic radiation force depend on the ultrasound push beam (push duration, -number, etc.) and the viscoelasticity of the medium, and therefore are different across scanners from different vendors. As a result, scanners from different vendors may give different tissue elasticity measurements within the same patient. Various methods have been proposed to evaluate shear wave dispersion to better estimate tissue viscoelasticity. A rheological model such as the Kelvin-Voigt model is typically fitted to the shear wave dispersion to solve for the elasticity and viscosity of tissue. However, these rheological models impose strong assumptions about frequency dependence of elasticity and viscosity. Here, we propose a new method called Acoustic Radiation Force Induced Creep-Recovery (ARFICR) capable of quantifying rheological model-independent measurements of elasticity and viscosity for more robust tissue health assessment. In ARFICR, the creep-recovery time signal at the focus of the push beam is used to calculate the relative elasticity and viscosity (scaled by an unknown constant) over a wide frequency range. Shear waves generated during the ARFICR measurement are also detected and used to calculate the shear wave velocity at its center frequency, which is then used to calibrate the relative elasticity and viscosity to absolute elasticity and viscosity. In this paper, finite-element method simulations and experiments in tissue mimicking phantoms are used to validate and characterize the extent of viscoelastic quantification of ARFICR. The results suggest that ARFICR can measure tissue

  7. Size effect of the elastic modulus of rectangular nanobeams: Surface elasticity effect

    International Nuclear Information System (INIS)

    Yao Hai-Yan; Fan Wen-Liang; Yun Guo-Hong

    2013-01-01

    The size-dependent elastic property of rectangular nanobeams (nanowires or nanoplates) induced by the surface elasticity effect is investigated by using a developed modified core-shell model. The effect of surface elasticity on the elastic modulus of nanobeams can be characterized by two surface related parameters, i.e., inhomogeneous degree constant and surface layer thickness. The analytical results show that the elastic modulus of the rectangular nanobeam exhibits a distinct size effect when its characteristic size reduces below 100 nm. It is also found that the theoretical results calculated by a modified core-shell model have more obvious advantages than those by other models (core-shell model and core-surface model) by comparing them with relevant experimental measurements and computational results, especially when the dimensions of nanostructures reduce to a few tens of nanometers. (condensed matter: structural, mechanical, and thermal properties)

  8. Conical Refraction of Elastic Waves by Anisotropic Metamaterials and Application for Parallel Translation of Elastic Waves.

    Science.gov (United States)

    Ahn, Young Kwan; Lee, Hyung Jin; Kim, Yoon Young

    2017-08-30

    Conical refraction, which is quite well-known in electromagnetic waves, has not been explored well in elastic waves due to the lack of proper natural elastic media. Here, we propose and design a unique anisotropic elastic metamaterial slab that realizes conical refraction for horizontally incident longitudinal or transverse waves; the single-mode wave is split into two oblique coupled longitudinal-shear waves. As an interesting application, we carried out an experiment of parallel translation of an incident elastic wave system through the anisotropic metamaterial slab. The parallel translation can be useful for ultrasonic non-destructive testing of a system hidden by obstacles. While the parallel translation resembles light refraction through a parallel plate without angle deviation between entry and exit beams, this wave behavior cannot be achieved without the engineered metamaterial because an elastic wave incident upon a dissimilar medium is always split at different refraction angles into two different modes, longitudinal and shear.

  9. Vascular elastic photoacoustic tomography in humans

    Science.gov (United States)

    Hai, Pengfei; Zhou, Yong; Liang, Jinyang; Li, Chiye; Wang, Lihong V.

    2016-03-01

    Quantification of vascular elasticity can help detect thrombosis and prevent life-threatening conditions such as acute myocardial infarction or stroke. Here, we propose vascular elastic photoacoustic tomography (VE-PAT) to measure vascular elasticity in humans. VE-PAT was developed by incorporating a linear-array-based photoacoustic computed tomography system with a customized compression stage. By measuring the deformation of blood vessels under uniaxial loading, VE-PAT was able to quantify the vascular compliance. We first demonstrated the feasibility of VE-PAT in blood vessel phantoms. In large vessel phantoms, VE-PAT detected a decrease in vascular compliance due to simulated thrombosis, which was validated by a standard compression test. In small blood vessel phantoms embedded 3 mm deep in gelatin, VE-PAT detected elasticity changes at depths that are difficult to image using other elasticity imaging techniques. We then applied VE-PAT to assess vascular compliance in a human subject and detected a decrease in vascular compliance when an occlusion occurred downstream from the measurement point, demonstrating the potential of VE-PAT in clinical applications such as detection of deep venous thrombosis.

  10. Probing hysteretic elasticity in weakly nonlinear materials

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, Paul A [Los Alamos National Laboratory; Haupert, Sylvain [UPMC UNIV PARIS; Renaud, Guillaume [UPMC UNIV PARIS; Riviere, Jacques [UPMC UNIV PARIS; Talmant, Maryline [UPMC UNIV PARIS; Laugier, Pascal [UPMC UNIV PARIS

    2010-12-07

    Our work is aimed at assessing the elastic and dissipative hysteretic nonlinear parameters' repeatability (precision) using several classes of materials with weak, intermediate and high nonlinear properties. In this contribution, we describe an optimized Nonlinear Resonant Ultrasound Spectroscopy (NRUS) measuring and data processing protocol applied to small samples. The protocol is used to eliminate the effects of environmental condition changes that take place during an experiment, and that may mask the intrinsic elastic nonlinearity. As an example, in our experiments, we identified external temperature fluctuation as a primary source of material resonance frequency and elastic modulus variation. A variation of 0.1 C produced a frequency variation of 0.01 %, which is similar to the expected nonlinear frequency shift for weakly nonlinear materials. In order to eliminate environmental effects, the variation in f{sub 0} (the elastically linear resonance frequency proportional to modulus) is fit with the appropriate function, and that function is used to correct the NRUS calculation of nonlinear parameters. With our correction procedure, we measured relative resonant frequency shifts of 10{sup -5} , which are below 10{sup -4}, often considered the limit to NRUS sensitivity under common experimental conditions. Our results show that the procedure is an alternative to the stringent control of temperature often applied. Applying the approach, we report nonlinear parameters for several materials, some with very small nonclassical nonlinearity. The approach has broad application to NRUS and other Nonlinear Elastic Wave Spectroscopy approaches.

  11. Elastic Moduli of Permanently Densified Silica Glasses

    Science.gov (United States)

    Deschamps, T.; Margueritat, J.; Martinet, C.; Mermet, A.; Champagnon, B.

    2014-01-01

    Modelling the mechanical response of silica glass is still challenging, due to the lack of knowledge concerning the elastic properties of intermediate states of densification. An extensive Brillouin Light Scattering study on permanently densified silica glasses after cold compression in diamond anvil cell has been carried out, in order to deduce the elastic properties of such glasses and to provide new insights concerning the densification process. From sound velocity measurements, we derive phenomenological laws linking the elastic moduli of silica glass as a function of its densification ratio. The found elastic moduli are in excellent agreement with the sparse data extracted from literature, and we show that they do not depend on the thermodynamic path taken during densification (room temperature or heating). We also demonstrate that the longitudinal sound velocity exhibits an anomalous behavior, displaying a minimum for a densification ratio of 5%, and highlight the fact that this anomaly has to be distinguished from the compressibility anomaly of a-SiO2 in the elastic domain. PMID:25431218

  12. Population and energy elasticity of tornado casualties

    Science.gov (United States)

    Fricker, Tyler; Elsner, James B.; Jagger, Thomas H.

    2017-04-01

    Tornadoes are capable of catastrophic destruction and mass casualties, but there are yet no estimates of how sensitive the number of casualties are to changes in the number of people in harm's way or to changes in tornado energy. Here the relationship between tornado casualties (deaths and injuries), population, and energy dissipation is quantified using the economic concept of "elasticity." Records of casualties from individual tornadoes over the period 2007-2015 are fit to a regression model. The coefficient on the population term (population elasticity) indicates that a doubling in population increases the casualty rate by 21% [(17, 24)%, 95% credible interval]. The coefficient on the energy term (energy elasticity) indicates that a doubling in energy dissipation leads to a 33% [(30, 35)%, 95% credible interval] increase in the casualty rate. The difference in elasticity values show that on average, changes in energy dissipation have been relatively more important in explaining tornado casualties than changes in population. Assuming no changes in warning effectiveness or mitigation efforts, these elasticity estimates can be used to project changes in casualties given the known population trends and possible trends in tornado activity.

  13. Ab initio elastic properties and tensile strength of crystalline hydroxyapatite.

    Science.gov (United States)

    Ching, W Y; Rulis, Paul; Misra, A

    2009-10-01

    We report elastic constant calculation and a "theoretical" tensile experiment on stoichiometric hydroxyapatite (HAP) crystal using an ab initio technique. These results compare favorably with a variety of measured data. Theoretical tensile experiments are performed on the orthorhombic cell of HAP for both uniaxial and biaxial loading. The results show considerable anisotropy in the stress-strain behavior. It is shown that the failure behavior of the perfect HAP crystal is brittle for tension along the z-axis with a maximum stress of 9.6 GPa at 10% strain. Biaxial failure envelopes from six "theoretical" loading tests show a highly anisotropic pattern. Structural analysis of the crystal under various stages of tensile strain reveals that the deformation behavior manifests itself mainly in the rotation of the PO(4) tetrahedron with concomitant movements of both the columnar and axial Ca ions. These results are discussed in the context of mechanical properties of bioceramic composites relevant to mineralized tissues.

  14. Engineered elastomeric proteins with dual elasticity can be controlled by a molecular regulator.

    Science.gov (United States)

    Cao, Yi; Li, Hongbin

    2008-08-01

    Elastomeric proteins are molecular springs that confer excellent mechanical properties to many biological tissues and biomaterials. Depending on the role performed by the tissue or biomaterial, elastomeric proteins can behave as molecular springs or shock absorbers. Here we combine single-molecule atomic force microscopy and protein engineering techniques to create elastomeric proteins that can switch between two distinct types of mechanical behaviour in response to the binding of a molecular regulator. The proteins are mechanically labile by design and behave as entropic springs with an elasticity that is governed by their configurational entropy. However, when a molecular regulator binds to the protein, it switches into a mechanically stable state and can act as a shock absorber. These engineered proteins effectively mimic and combine the two extreme forms of elastic behaviour found in natural elastomeric proteins, and thus represent a new type of smart nanomaterial that will find potential applications in nanomechanics and material sciences.

  15. Immunohistochemical study of extracellular matrices and elastic fibers in a human sternoclavicular joint.

    Science.gov (United States)

    Shimada, K; Takeshige, N; Moriyama, H; Miyauchi, Y; Shimada, S; Fujimaki, E

    1997-12-01

    In this study, we clarified the distribution of elastic and oxytalan fibers in a human sternoclavicular joint (SCJ) using a color image system and in extracellular matrices using immunoperoxidase staining. Fine elastic fibers (EFs) were scattered in the fibrous layer of the sternoclavicular disk. This articular disk was composed of a collagenous bundle on the sternum side of the articular disk in the SCJ and cellular components including connective tissue on the clavicular side of the articular disk. The thickness of the disk gradually increased from the inferior to superior portion. Collagen fibers type I, III and V and other extracellular matrices (ECMs) were detected in the hypertrophic zone in the clavicular and sternum side of the SCJ and in the connective tissue of the articulatio condylar. On the cervical surface of the articular disk, cellular activity was higher than on the sternum surface.

  16. Modulation of the gene expression of annulus fibrosus-derived stem cells using poly(ether carbonate urethane)urea scaffolds of tunable elasticity.

    Science.gov (United States)

    Zhu, Caihong; Li, Jun; Liu, Chen; Zhou, Pinghui; Yang, Huilin; Li, Bin

    2016-01-01

    Annulus fibrosus (AF) injuries commonly lead to substantial deterioration of the intervertebral disc (IVD). While tissue engineering has recently evolved into a promising approach for AF regeneration, it remains challenging due to the cellular, biochemical, and mechanical heterogeneity of AF tissue. In this study, we explored the use of AF-derived stem cells (AFSCs) to achieve diversified differentiation of cells for AF tissue engineering. Since the differentiation of stem cells relies significantly on the elasticity of the substrate, we synthesized a series of biodegradable poly(ether carbonate urethane)urea (PECUU) materials whose elasticity approximated that of native AF tissue. When AFSCs were cultured on electrospun PECUU fibrous scaffolds, the gene expression of collagen-I in the cells increased with the elasticity of scaffold material, whereas the expression of collagen-II and aggrecan genes showed an opposite trend. At the protein level, the content of collagen-I gradually increased with substrate elasticity, while collagen-II and GAG contents decreased. In addition, the cell traction forces (CTFs) of AFSCs gradually decreased with scaffold elasticity. Such substrate elasticity-dependent changes of AFSCs were similar to the gradual transition in the genetic, biochemical, and biomechanical characteristics of cells from inner to outer regions of native AF tissue. Together, findings from this study indicate that AFSCs, depending on the substrate elasticity, have strong tendencies to differentiate into various types of AF-like cells, thereby providing a solid foundation for the tissue engineering applications of AFSCs. Repairing the annulus fibrosus (AF) of intervertebral disc (IVD) is critical for the treatment of disc degeneration disease, but remains challenging due to the significant heterogeneity of AF tissue. Previously, we have identified rabbit AF-derived stem cells (AFSCs), which are AF tissue-specific and hold promise for AF regeneration. In this

  17. Alumina strength degradation in the elastic regime

    International Nuclear Information System (INIS)

    Furnish, Michael D.; Chhabildas, Lalit C.

    1998-01-01

    Measurements of Kanel et al. [1991] have suggested that deviatoric stresses in glasses shocked to nearly the Hugoniot Elastic Limit (HEL) relax over a time span of microseconds after initial loading. 'Failure' (damage) waves have been inferred on the basis of these measurements using time-resolved manganin normal and transverse stress gauges. Additional experiments on glass by other researchers, using time-resolved gauges, high-speed photography and spall strength determinations have also lead to the same conclusions. In the present study we have conducted transmitted-wave experiments on high-quality Coors AD995 alumina shocked to roughly 5 and 7 GPa (just below or at the HEL). The material is subsequently reshocked to just above its elastic limit. Results of these experiments do show some evidence of strength degradation in the elastic regime

  18. Facies Constrained Elastic Full Waveform Inversion

    KAUST Repository

    Zhang, Z.

    2017-05-26

    Current efforts to utilize full waveform inversion (FWI) as a tool beyond acoustic imaging applications, for example for reservoir analysis, face inherent limitations on resolution and also on the potential trade-off between elastic model parameters. Adding rock physics constraints does help to mitigate these issues. However, current approaches to add such constraints are based on averaged type rock physics regularization terms. Since the true earth model consists of different facies, averaging over those facies naturally leads to smoothed models. To overcome this, we propose a novel way to utilize facies based constraints in elastic FWI. A so-called confidence map is calculated and updated at each iteration of the inversion using both the inverted models and the prior information. The numerical example shows that the proposed method can reduce the cross-talks and also can improve the resolution of inverted elastic properties.

  19. Facies Constrained Elastic Full Waveform Inversion

    KAUST Repository

    Zhang, Z.; Zabihi Naeini, E.; Alkhalifah, Tariq Ali

    2017-01-01

    Current efforts to utilize full waveform inversion (FWI) as a tool beyond acoustic imaging applications, for example for reservoir analysis, face inherent limitations on resolution and also on the potential trade-off between elastic model parameters. Adding rock physics constraints does help to mitigate these issues. However, current approaches to add such constraints are based on averaged type rock physics regularization terms. Since the true earth model consists of different facies, averaging over those facies naturally leads to smoothed models. To overcome this, we propose a novel way to utilize facies based constraints in elastic FWI. A so-called confidence map is calculated and updated at each iteration of the inversion using both the inverted models and the prior information. The numerical example shows that the proposed method can reduce the cross-talks and also can improve the resolution of inverted elastic properties.

  20. Elastic interaction energies of defect structures

    International Nuclear Information System (INIS)

    Seitz, E.; de Fontaine, D.

    1976-01-01

    The elastic strain energy between point defects and small disk-shaped clusters of defects are calculated to determine stable configurations. A distortion tensor of tetragonal symmetry is assigned to each impurity atom. The tetragonality ratio t is varied to cover needle-type (t greater than 1), spherical (t = 1) and disk-type (t less than 0) strain fields. To vary the elastic properties of the host material, Fe, Cu, Al, and V were chosen as examples. Computer calculations are based on the microscopic theory of elasticity which emphasizes calculations in discrete Fourier space. Pairs of point defects order along [001] for t less than 1 and along (001) for t = 1 for all host elements. For t greater than 1 fcc lattices and bcc lattices behave differently. It is shown that only certain three dimensional periodic arrangements of parallel and perpendicular disk-like defect clusters are realized for given tetragonality ratio t and host element

  1. Elastic properties of some transition metal arsenides

    Science.gov (United States)

    Nayak, Vikas; Verma, U. P.; Bisht, P. S.

    2018-05-01

    The elastic properties of transition metal arsenides (TMAs) have been studied by employing Wien2K package based on density functional theory in the zinc blende (ZB) and rock salt (RS) phase treating valance electron scalar relativistically. Further, we have also treated them non-relativistically to find out the relativistic effect. We have calculated the elastic properties by computing the volume conservative stress tensor for small strains, using the method developed by Charpin. The obtained results are discussed in paper. From the obtained results, it is clear that the values of C11 > C12 and C44 for all the compounds. The values of shear moduli of these compounds are also calculated. The internal parameter for these compounds shows that ZB structures of these compounds have high resistance against bond order. We find that the estimated elastic constants are in good agreement with the available data.

  2. Elastic Gauge Fields in Weyl Semimetals

    Science.gov (United States)

    Cortijo, Alberto; Ferreiros, Yago; Landsteiner, Karl; Hernandez Vozmediano, Maria Angeles

    We show that, as it happens in graphene, elastic deformations couple to the electronic degrees of freedom as pseudo gauge fields in Weyl semimetals. We derive the form of the elastic gauge fields in a tight-binding model hosting Weyl nodes and see that this vector electron-phonon coupling is chiral, providing an example of axial gauge fields in three dimensions. As an example of the new response functions that arise associated to these elastic gauge fields, we derive a non-zero phonon Hall viscosity for the neutral system at zero temperature. The axial nature of the fields provides a test of the chiral anomaly in high energy with three axial vector couplings. European Union structural funds and the Comunidad de Madrid MAD2D-CM Program (S2013/MIT-3007).

  3. Modeling elastic anisotropy in strained heteroepitaxy.

    Science.gov (United States)

    Dixit, Gopal Krishna; Ranganathan, Madhav

    2017-09-20

    Using a continuum evolution equation, we model the growth and evolution of quantum dots in the heteroepitaxial Ge on Si(0 0 1) system in a molecular beam epitaxy unit. We formulate our model in terms of evolution due to deposition, and due to surface diffusion which is governed by a free energy. This free energy has contributions from surface energy, curvature, wetting effects and elastic energy due to lattice mismatch between the film and the substrate. In addition to anisotropy due to surface energy which favors facet formation, we also incorporate elastic anisotropy due to an underlying crystal lattice. The complicated elastic problem of the film-substrate system subjected to boundary conditions at the free surface, interface and the bulk substrate is solved by perturbation analysis using a small slope approximation. This permits an analysis of effects at different orders in the slope and sheds new light on the observed behavior. Linear stability analysis shows the early evolution of the instability towards dot formation. The elastic anisotropy causes a change in the alignment of dots in the linear regime, whereas the surface energy anisotropy changes the dot shapes at the nonlinear regime. Numerical simulation of the full nonlinear equations shows the evolution of the surface morphology. In particular, we show, for parameters of the [Formula: see text] [Formula: see text] on Si(0 0 1), the surface energy anisotropy dominates the shapes of the quantum dots, whereas their alignment is influenced by the elastic energy anisotropy. The anisotropy in elasticity causes a further elongation of the islands whose coarsening is interrupted due to [Formula: see text] facets on the surface.

  4. Modeling elastic anisotropy in strained heteroepitaxy

    Science.gov (United States)

    Krishna Dixit, Gopal; Ranganathan, Madhav

    2017-09-01

    Using a continuum evolution equation, we model the growth and evolution of quantum dots in the heteroepitaxial Ge on Si(0 0 1) system in a molecular beam epitaxy unit. We formulate our model in terms of evolution due to deposition, and due to surface diffusion which is governed by a free energy. This free energy has contributions from surface energy, curvature, wetting effects and elastic energy due to lattice mismatch between the film and the substrate. In addition to anisotropy due to surface energy which favors facet formation, we also incorporate elastic anisotropy due to an underlying crystal lattice. The complicated elastic problem of the film-substrate system subjected to boundary conditions at the free surface, interface and the bulk substrate is solved by perturbation analysis using a small slope approximation. This permits an analysis of effects at different orders in the slope and sheds new light on the observed behavior. Linear stability analysis shows the early evolution of the instability towards dot formation. The elastic anisotropy causes a change in the alignment of dots in the linear regime, whereas the surface energy anisotropy changes the dot shapes at the nonlinear regime. Numerical simulation of the full nonlinear equations shows the evolution of the surface morphology. In particular, we show, for parameters of the Ge0.25 Si0.75 on Si(0 0 1), the surface energy anisotropy dominates the shapes of the quantum dots, whereas their alignment is influenced by the elastic energy anisotropy. The anisotropy in elasticity causes a further elongation of the islands whose coarsening is interrupted due to facets on the surface.

  5. Dynamic nonlinear elasticity in geo materials

    International Nuclear Information System (INIS)

    Ostrovsky, L.A.; Johnson, P.A.

    2001-01-01

    The nonlinear elastic behaviour of earth materials is an extremely rich topic, one that has broad implications to earth and materials sciences, including strong ground motion, rock physics, nondestructive evaluation and materials science. The mechanical properties of rock appear to place it in a broader class of materials, it can be named the Structural nonlinear elasticity class (also Mesoscopic/nano scale elasticity, or MS/NSE class). These terms are in contrast to materials that display classical, Atomic Elasticity, such as most fluids and monocrystalline solids. The difference between these two categories of materials is both in intensity and origin of their nonlinear response. The nonlinearity of atomic elastic materials is due to the atomic/molecular lattice anharmonicity. The latter is relatively small because the intermolecular forces are extremely strong. In contrast, the materials considered below contain small soft features that it is called the bond system (cracks, grain contacts, dislocations, etc.) within a hard matrix and relaxation (slow dynamical effects) are characteristic, non of which appear in atomic elastic materials. The research begins with a brief historical background from nonlinear acoustics to the recent developments in rock nonlinearity. This is followed by an overview of some representative laboratory measurements which serve as primary indicators of nonlinear behaviour, followed by theoretical development, and finally, mention a variety of observations of nonlinearity under field conditions and applications to nondestructive testing of materials. The goal is not to survey all papers published in the are but to demonstrate some experimental and theoretical results and ideas that will the reader to become oriented in this broad and rapidly growing area bridging macro-, meso- and microscale (nano scale) phenomena in physics, materials science, and geophysics

  6. Non-linear theory of elasticity

    CERN Document Server

    Lurie, AI

    2012-01-01

    This book examines in detail the Theory of Elasticity which is a branch of the mechanics of a deformable solid. Special emphasis is placed on the investigation of the process of deformation within the framework of the generally accepted model of a medium which, in this case, is an elastic body. A comprehensive list of Appendices is included providing a wealth of references for more in depth coverage. The work will provide both a stimulus for future research in this field as well as useful reference material for many years to come.

  7. Modeling Pseudo-elastic Behavior of Springback

    International Nuclear Information System (INIS)

    Xia, Z. Cedric

    2005-01-01

    One of the principal foundations of mathematical theory of conventional plasticity for rate-independent metals is that there exists a well-defined yield surface in stress space for any material point under deformation. A material point can undergo further plastic deformation if the applied stresses are beyond current yield surface which is generally referred as 'plastic loading'. On the other hand, if the applied stress state falls within or on the yield surface, the metal will deform elastically only and is said to be undergoing 'elastic unloading'. Although it has been always recognized throughout the history of development of plasticity theory that there is indeed inelastic deformation accompanying elastic unloading, which leads to metal's hysteresis behavior, its effects were thought to be negligible and were largely ignored in the mathematical treatment.Recently there have been renewed interests in the study of unloading behavior of sheet metals upon large plastic deformation and its implications on springback prediction. Springback is essentially an elastic recovery process of a formed sheet metal blank when it is released from the forming dies. Its magnitude depends on the stress states and compliances of the deformed sheet metal if no further plastic loading occurs during the relaxation process. Therefore the accurate determination of material compliances during springback and its effective incorporation into simulation software are important aspects for springback calculation. Some of the studies suggest that the unloading curve might deviate from linearity, and suggestions were made that a reduced elastic modulus be used for springback simulation.The aim of this study is NOT to take a position on the debate of whether elastic moduli are changed during sheet metal forming process. Instead we propose an approach of modeling observed psuedoelastic behavior within the context of mathematical theory of plasticity, where elastic moduli are treated to be

  8. Wave propagation in elastic layers with damping

    DEFF Research Database (Denmark)

    Sorokin, Sergey; Darula, Radoslav

    2016-01-01

    The conventional concepts of a loss factor and complex-valued elastic moduli are used to study wave attenuation in a visco-elastic layer. The hierarchy of reduced-order models is employed to assess attenuation levels in various situations. For the forcing problem, the attenuation levels are found...... for alternative excitation cases. The differences between two regimes, the low frequency one, when a waveguide supports only one propagating wave, and the high frequency one, when several waves are supported, are demonstrated and explained....

  9. Elastic-plastic-creep analysis of shells

    International Nuclear Information System (INIS)

    Pai, D.H.

    1979-01-01

    This paper presents the recent experience of a designer/fabricator of nuclear heat transport components in the area of elastic-plastic-creep analysis of shell-like structures. A brief historical perspective is first given to highlight the evolution leading to the present industry practice. The ASME elevated temperature design criteria will be discussed followed by examples of actual computations performed to support the design/analysis and fabrication of a breeder reactor component in which a substantial amount of elastic-plastic-creep analysis was performed. Mathematical challenges encountered by the design analyst in these problems will be highlighted. Developmental needs and future trends will then be given

  10. An introduction to the theory of elasticity

    CERN Document Server

    Atkin, R J

    2005-01-01

    Thanks to intense research activity in the field of continuum mechanics, the teaching of subjects such as elasticity theory has attained a high degree of clarity and simplicity. This introductory volume offers upper-level undergraduates a perspective based on modern developments that also takes into account the limited mathematical tools they are likely to have at their disposal. It also places special emphasis on areas that students often find difficult upon first encounter. An Introduction to the Theory of Elasticity provides an accessible guide to the subject in a form that will instill a f

  11. Effect of elastic boundaries in hydrostatic problems

    Science.gov (United States)

    Volobuev, A. N.; Tolstonogov, A. P.

    2010-03-01

    The possibility and conditions of use of the Bernoulli equation for description of an elastic pipeline were considered. It is shown that this equation is identical in form to the Bernoulli equation used for description of a rigid pipeline. It has been established that the static pressure entering into the Bernoulli equation is not identical to the pressure entering into the impulse-momentum equation. The hydrostatic problem on the pressure distribution over the height of a beaker with a rigid bottom and elastic walls, filled with a liquid, was solved.

  12. The elastic response of composite materials

    International Nuclear Information System (INIS)

    Laws, N.

    1980-01-01

    The theory of linear elasticity is used to study the elastic response of composite materials. The main concern is the prediction of overall moduli. Some attention is paid to the problem of deciding upon when the idea of an overall modulus is meaningful. In addition it is shown how to calculate some rigorous bounds on the overall moduli, and some predictions of the self-consistent method are discussed. The paper mainly concentrates on isotropic dispersions of spheres, unidirectional fibre-reinforced materials and laminates. (author)

  13. Elastic band prediction equations for combined free-weight and elastic band bench presses and squats.

    Science.gov (United States)

    Shoepe, Todd C; Ramirez, David A; Almstedt, Hawley C

    2010-01-01

    Elastic bands added to traditional free-weight techniques have become a part of suggested training routines in recent years. Because of the variable loading patterns of elastic bands (i.e., greater stretch produces greater resistance), it is necessary to quantify the exact loading patterns of bands to identify the volume and intensity of training. The purpose of this study was to determine the length vs. tension properties of multiple sizes of a set of commonly used elastic bands to quantify the resistance that would be applied to free-weight plus elastic bench presses (BP) and squats (SQ). Five elastic bands of varying thickness were affixed to an overhead support beam. Dumbbells of varying weights were progressively added to the free end while the linear deformation was recorded with each subsequent weight increment. The resistance was plotted as a factor of linear deformation, and best-fit nonlinear logarithmic regression equations were then matched to the data. For both the BP and SQ loading conditions and all band thicknesses tested, R values were greater than 0.9623. These data suggest that differences in load exist as a result of the thickness of the elastic band, attachment technique, and type of exercise being performed. Facilities should adopt their own form of loading quantification to match their unique set of circumstances when acquiring, researching, and implementing elastic band and free-weight exercises into the training programs.

  14. Viscous-elastic dynamics of power-law fluids within an elastic cylinder

    Science.gov (United States)

    Boyko, Evgeniy; Bercovici, Moran; Gat, Amir D.

    2017-07-01

    In a wide range of applications, microfluidic channels are implemented in soft substrates. In such configurations, where fluidic inertia and compressibility are negligible, the propagation of fluids in channels is governed by a balance between fluid viscosity and elasticity of the surrounding solid. The viscous-elastic interactions between elastic substrates and non-Newtonian fluids are particularly of interest due to the dependence of viscosity on the state of the system. In this work, we study the fluid-structure interaction dynamics between an incompressible non-Newtonian fluid and a slender linearly elastic cylinder under the creeping flow regime. Considering power-law fluids and applying the thin shell approximation for the elastic cylinder, we obtain a nonhomogeneous p-Laplacian equation governing the viscous-elastic dynamics. We present exact solutions for the pressure and deformation fields for various initial and boundary conditions for both shear-thinning and shear-thickening fluids. We show that in contrast to Stokes' problem where a compactly supported front is obtained for shear-thickening fluids, here the role of viscosity is inversed and such fronts are obtained for shear-thinning fluids. Furthermore, we demonstrate that for the case of a step in inlet pressure, the propagation rate of the front has a tn/n +1 dependence on time (t ), suggesting the ability to indirectly measure the power-law index (n ) of shear-thinning liquids through measurements of elastic deformation.

  15. Brief report: reconstruction of joint hyaline cartilage by autologous progenitor cells derived from ear elastic cartilage.

    Science.gov (United States)

    Mizuno, Mitsuru; Kobayashi, Shinji; Takebe, Takanori; Kan, Hiroomi; Yabuki, Yuichiro; Matsuzaki, Takahisa; Yoshikawa, Hiroshi Y; Nakabayashi, Seiichiro; Ik, Lee Jeong; Maegawa, Jiro; Taniguchi, Hideki

    2014-03-01

    In healthy joints, hyaline cartilage covering the joint surfaces of bones provides cushioning due to its unique mechanical properties. However, because of its limited regenerative capacity, age- and sports-related injuries to this tissue may lead to degenerative arthropathies, prompting researchers to investigate a variety of cell sources. We recently succeeded in isolating human cartilage progenitor cells from ear elastic cartilage. Human cartilage progenitor cells have high chondrogenic and proliferative potential to form elastic cartilage with long-term tissue maintenance. However, it is unknown whether ear-derived cartilage progenitor cells can be used to reconstruct hyaline cartilage, which has different mechanical and histological properties from elastic cartilage. In our efforts to develop foundational technologies for joint hyaline cartilage repair and reconstruction, we conducted this study to obtain an answer to this question. We created an experimental canine model of knee joint cartilage damage, transplanted ear-derived autologous cartilage progenitor cells. The reconstructed cartilage was rich in proteoglycans and showed unique histological characteristics similar to joint hyaline cartilage. In addition, mechanical properties of the reconstructed tissues were higher than those of ear cartilage and equal to those of joint hyaline cartilage. This study suggested that joint hyaline cartilage was reconstructed from ear-derived cartilage progenitor cells. It also demonstrated that ear-derived cartilage progenitor cells, which can be harvested by a minimally invasive method, would be useful for reconstructing joint hyaline cartilage in patients with degenerative arthropathies. © AlphaMed Press.

  16. Money flexibility, price elasticity, and elasticity of marginal utility of consumption

    OpenAIRE

    Malakhov, Sergey

    2014-01-01

    The development of G.Stigler’s original model of search describes the mathematical relationship between the elasticity of the marginal utility of consumption, the price elasticity, and the elasticity of the marginal utility of money income with respect to increase in the price of living and/or to inflation. This relationship can be used not only in economics of well-being but also in microeconomics where the increase in the price of living, i.e., in purchase price, can make consumption “bad” ...

  17. Stressed-deformed state of mountain rocks in elastic stage and between elasticity

    Directory of Open Access Journals (Sweden)

    Samedov A.M.

    2017-12-01

    Full Text Available The problems of the stress-strain state of rocks in the elastic stage and beyond the elastic limits, and the ways of schematizing the tension and compression diagrams were reviewed in the article. To simplify calculations outside the elastic range, the tension (compression diagrams are usually schematized, i.e. are replaced by curved smooth lines having a fairly simple mathematical expression and at the same time well coinciding with the experimentally obtained diagrams. When diagram is to be schematized, it is necessary to take a constant temperature of superheated water steam if a rock test is planned in a relaxed form. Note that when the diagram is schematizing, the difference between the limits of proportionality and fluidity is erased. This allows the limit of proportionality to be considered the limit of fluidity. Schematicization can be carried out in the area where the tensile strength (compression is planned to be destroyed with the established weakening of rocks by exposure to water steam or chemical reagents. Samples of rocks in natural form were tested and weakened by means of superheated water steam (220 °C and more and chemical reagents for tension and compression. The data are obtained, the diagrams of deformation are constructed and schematized in the elastic stage and beyond the elastic limit. Based on the schematic diagrams of deformation, the components of stress and strain were composed in the elastic stage and beyond the elastic limit. It is established in the publication that rocks under compression and stretching deform, both within the elastic stage, and beyond the limits of elasticity. This could be seen when the samples, both in natural and in weakened state, with superheated water steam (more than 220 °C or chemical reagents were tested. In their natural form, they are mainly deformed within the elastic stage and are destroyed as a brittle material, and in a weakened form they can deform beyond the elastic stage and

  18. Elastic softness of hybrid lead halide perovskites

    KAUST Repository

    Ferreira, A. C.; Lé toublon, A.; Paofai, S.; Raymond, S.; Ecolivet, C.; Rufflé , B.; Cordier, S.; Katan, C.; Saidaminov, Makhsud I.; Zhumekenov, A. A.; Bakr, Osman; Even, J.; Bourges, Ph.

    2018-01-01

    scattering, low frequency acoustic phonons in four different hybrid perovskite single crystals: MAPbBr3, FAPbBr3, MAPbI3 and α-FAPbI3 (MA: methylammonium, FA: formamidinium). We report a complete set of elastic constants caracterized by a very soft shear

  19. On elastic structural elements for nuclear reactors

    International Nuclear Information System (INIS)

    Povolo, F.

    1978-03-01

    The in-pile stress-relaxation behaviour of materials usually employed for the elastic structural elements, in nuclear reactors, is critically reviewed and the results are compared with those obtained in commercial zirconium alloys irradiated under similar conditions. Finally, it is shown that, under certain conditions, some zirconium alloys may be used as an alternative material for these structural elements. (orig.) [de

  20. On the K+-nucleus elastic scattering

    International Nuclear Information System (INIS)

    Ning, P.; Men, D.

    1991-01-01

    In this paper conventional and unconventional nuclear medium effects in the K + scattering are briefly reviewed. Microscopic calculations of the K + elastic scattering on 4 He, 12 C, 40 Ca, 120 Sn at 800 MeV/c are performed and then possible swellings of nucleons in nuclei are discussed

  1. Extremal Overall Elastic Response of Polycrystalline Materials

    DEFF Research Database (Denmark)

    Bendsøe, Martin P; Lipton, Robert

    1997-01-01

    Polycrystalline materials comprised of grains obtained from a single anisotropic material are considered in the framework of linear elasticity. No assumptions on the symmetry of the polycrystal are made. We subject the material to independent external strain and stress fields with prescribed mean...

  2. Solitary waves on nonlinear elastic rods. II

    DEFF Research Database (Denmark)

    Sørensen, Mads Peter; Christiansen, Peter Leth; Lomdahl, P. S.

    1987-01-01

    In continuation of an earlier study of propagation of solitary waves on nonlinear elastic rods, numerical investigations of blowup, reflection, and fission at continuous and discontinuous variation of the cross section for the rod and reflection at the end of the rod are presented. The results ar...... are compared with predictions of conservation theorems for energy and momentum....

  3. Hadron elastic scattering at small angles

    CERN Multimedia

    2002-01-01

    This experiment is an extension of the measurements of the WA9 experiment up to the highest energies available in the North Area. It will measure the differential cross-section for hadron elastic scattering in the t-range 0.002-0.05 (GeV/c)$^{2}$ using an ionization chamber for the measurement of the energy and the angle of the recoil and a magnet-WC spectrometer to measure the momentum and direction of the forward particle. From these measurements will be obtained the ratio $\\rho$ of the real to imaginary parts of the forward elastic amplitude and the exponential slope parameter b of the hadronic amplitude at small t. The precision expected in these measurements is $\\Delta \\rho \\approx \\pm 0.01$ and $\\Delta$b $\\approx \\pm 0.2$ (GeV/c)$^{-2}$. \\\\ \\\\ The experimental programme includes: \\\\\\\\ i) measurements of $\\rho$ and b for $\\pi$p elastic scattering at incident momenta between 150 GeV/c and 300 GeV/c; \\\\ ii) measurements of $\\rho$ and b for $\\pi^{+}$p and pp elastic scattering at incident momenta between 5...

  4. First-principles elasticity of monocarboaluminate hydrates

    KAUST Repository

    Moon, J.

    2014-07-01

    The elasticity of monocarboaluminate hydrates, 3CaO·Al2O3·CaCO3·xH2O (x = 11 or 8), has been investigated by first-principles calculations. Previous experimental study revealed that the fully hydrated monocarboaluminate (x = 11) exhibits exceptionally low compressibility compared to other reported calcium aluminate hydrates. This stiff hydration product can contribute to the strength of concrete made with Portland cements containing calcium carbonates. In this study, full elastic tensors and mechanical properties of the crystal structures with different water contents (x = 11 or 8) are computed by first-principles methods based on density functional theory. The results indicate that the compressibility of monocarboaluminate is highly dependent on the water content in the interlayer region. The structure also becomes more isotropic with the addition of water molecules in this region. Since the monocarboaluminate is a key hydration product of limestone added cement, elasticity of the crystal is important to understand its mechanical impact on concrete. Besides, it is put forth that this theoretical calculation will be useful in predicting the elastic properties of other complex cementitous materials and the influence of ion exchange on compressibility.

  5. Quasi-elastic Neutrino Scattering - an Overview

    International Nuclear Information System (INIS)

    Sobczyk, Jan T.

    2011-01-01

    A non-technical overview of charge current quasi-elastic neutrino interaction is presented. Many body computations of multinucleon ejection which is proposed to explain recent large axial mass measurements are discussed. A few comments on recent experimental results reported at NuInt11 workshop are included.

  6. Elastic proton-proton scattering at RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Yip, K.

    2011-09-03

    Here we describe elastic proton+proton (p+p) scattering measurements at RHIC in p+p collisions with a special optics run of {beta}* {approx} 21 m at STAR, at the center-of-mass energy {radical}s = 200 GeV during the last week of the RHIC 2009 run. We present preliminary results of single and double spin asymmetries.

  7. Plane strain problem in microstretch elastic solid

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    College, Patti 143 416, India. 3Department of Mathematics, Guru Nanak Dev University, Amritsar 143 005, ... lem in microstretch elastic solid by employing the eigenvalue approach. 975. Page 2. 976. Rajneesh Kumar et al. 2. Basic equations ..... of the matrix A are characteristic roots of (29) assuming that real parts of qs.

  8. Price Elasticity of Alcohol Demand in India.

    Science.gov (United States)

    Kumar, Santosh

    2017-05-01

    Using a household survey conducted in 2014, this study estimates price elasticity of demand (PED) for beer, country liquor and spirits in India. Ordinary least-square models were used to estimate the responsiveness in alcohol demand due to price change. A large number of control variables were included to adjust for potential confounding in the model. Inter-district variation in alcohol consumption is adjusted for by including district fixed effects. Alcohol prices are negatively associated with demand for alcoholic beverages. The PED ranged from -0.14 for spirits to -0.46 for country liquor. Low level of education was positively associated with spirits consumption. The magnitude of elasticity varied by rural-urban, education and gender. Results indicate that a policy mix of price controls and awareness campaigns would be most effective in tackling the adverse effects of harmful drinking in India. The demand for beer, country liquor and spirits is negatively associated with its own price. The elasticity estimates ranged from -0.14 for spirits to -0.44 for country liquor. The elasticity estimates varied by rural-urban, gender and by education levels of the drinkers. © The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved

  9. Elastic kirchhoff migration for vertical seismic profiles

    International Nuclear Information System (INIS)

    Keho, T.H.; Wu, R.S.

    1987-01-01

    Elastic Kirchhoff migration is implemented for the VSP recording geometry. The resulting migration formula requires measurement of the stress as well as the displacement. Since stress is not measured in a VSP, and in many cases the horizontal component of displacement is not measured, approximate migration formulas are given for these cases. The elastic migration formula for the case where only the vertical components are available, is the same as the acoustic migration formula, where the pressure data are replaced by the magnitudes of the elastic data as reconstructed from the vertical components, and the acoustic Green's functions are replaced with either the P or S wave elastic Green's functions. Two expressions for migration of two component displacement data are presented. In the first, the terms involving traction data are simply ignored. In the second, an improved backpropagation operator for the displacement field is obtained by replacing the traction data in the Kirchhoff integral by displacement data using Hooke's law. The migration expressions for the cases where two component data are available produce images which are less contaminated by artifacts than the migration images of one component data

  10. Some remarks on elastic fracture mechanics

    International Nuclear Information System (INIS)

    Destuynder, P.; Djaoua, M.; Lescure, S.

    1981-12-01

    A thermodynamical approach of propagation law in elastic media is given in this paper. From a particular choice of an energy dissipation potential, we deduce some propagation laws corresponding to particular loading cases. Finally a new computational method of the energy release rate is suggested and discussed from a computational point of view [fr

  11. A Linear Theory for Pretwisted Elastic Beams

    DEFF Research Database (Denmark)

    Krenk, Steen

    1983-01-01

    contains a general system of differential equations and gives explicit solutions for homogenous extension, torsion, and bending. The theory accounts explicitly for the shear center, the elastic center, and the axis of pretwist. The resulting torsion-extension coupling is in agreement with a recent...

  12. Elastic plastic buckling of elliptical vessel heads

    International Nuclear Information System (INIS)

    Alix, M.; Roche, R.L.

    1981-08-01

    The risks of buckling of dished vessel head increase when the vessel is thin walled. This paper gives the last results on experimental tests of 3 elliptical heads and compares all the results with some empirical formula dealing with elastic and plastic buckling

  13. Magma flow through elastic-walled dikes

    NARCIS (Netherlands)

    Bokhove, Onno; Woods, A.W.; de Boer, A

    2005-01-01

    A convection–diffusion model for the averaged flow of a viscous, incompressible magma through an elastic medium is considered. The magma flows through a dike from a magma reservoir to the Earth’s surface; only changes in dike width and velocity over large vertical length scales relative to the

  14. The theory of elastic waves and waveguides

    CERN Document Server

    Miklowitz, J

    1984-01-01

    The primary objective of this book is to give the reader a basic understanding of waves and their propagation in a linear elastic continuum. The studies of elastodynamic theory and its application to fundamental value problems should prepare the reader to tackle many physical problems of general interest in engineering and geophysics, and of particular interest in mechanics and seismology.

  15. Dynamic frictional contact for elastic viscoplastic material

    Directory of Open Access Journals (Sweden)

    Kenneth L. Kuttler

    2007-05-01

    Full Text Available Using a general theory for evolution inclusions, existence and uniqueness theorems are obtained for weak solutions to a frictional dynamic contact problem for elastic visco-plastic material. An existence theorem in the case where the friction coefficient is discontinuous is also presented.

  16. First-principles elasticity of monocarboaluminate hydrates

    KAUST Repository

    Moon, J.; Yoon, S.; Wentzcovitch, R. M.; Monteiro, P. J. M.

    2014-01-01

    The elasticity of monocarboaluminate hydrates, 3CaO·Al2O3·CaCO3·xH2O (x = 11 or 8), has been investigated by first-principles calculations. Previous experimental study revealed that the fully hydrated monocarboaluminate (x = 11) exhibits exceptionally low compressibility compared to other reported calcium aluminate hydrates. This stiff hydration product can contribute to the strength of concrete made with Portland cements containing calcium carbonates. In this study, full elastic tensors and mechanical properties of the crystal structures with different water contents (x = 11 or 8) are computed by first-principles methods based on density functional theory. The results indicate that the compressibility of monocarboaluminate is highly dependent on the water content in the interlayer region. The structure also becomes more isotropic with the addition of water molecules in this region. Since the monocarboaluminate is a key hydration product of limestone added cement, elasticity of the crystal is important to understand its mechanical impact on concrete. Besides, it is put forth that this theoretical calculation will be useful in predicting the elastic properties of other complex cementitous materials and the influence of ion exchange on compressibility.

  17. Elastic electron scattering at large momentum transfer

    International Nuclear Information System (INIS)

    Arnold, R.G.

    1979-05-01

    A review is given of elastic electron scattering at large momentum transfer (Q 2 > 20 fm -2 ) from nuclei with A less than or equal to 4. Recent experimental results are reviewed and the current problems in interpretation of these results are pointed out. Some questions for future experiments are posed, and a preview of possible future measurements is presented. 28 references

  18. Elastic modulus and fracture of boron carbide

    International Nuclear Information System (INIS)

    Hollenberg, G.W.; Walther, G.

    1978-12-01

    The elastic modulus of hot-pressed boron carbide with 1 to 15% porosity was measured at room temperature. K/sub IC/ values were determined for the same porosity range at 500 0 C by the double torsion technique. The critical stress intensity factor of boron carbide with 8% porosity was evaluated from 25 to 1200 0 C

  19. Membrane elastic properties and cell function.

    Directory of Open Access Journals (Sweden)

    Bruno Pontes

    Full Text Available Recent studies indicate that the cell membrane, interacting with its attached cytoskeleton, is an important regulator of cell function, exerting and responding to forces. We investigate this relationship by looking for connections between cell membrane elastic properties, especially surface tension and bending modulus, and cell function. Those properties are measured by pulling tethers from the cell membrane with optical tweezers. Their values are determined for all major cell types of the central nervous system, as well as for macrophage. Astrocytes and glioblastoma cells, which are considerably more dynamic than neurons, have substantially larger surface tensions. Resting microglia, which continually scan their environment through motility and protrusions, have the highest elastic constants, with values similar to those for resting macrophage. For both microglia and macrophage, we find a sharp softening of bending modulus between their resting and activated forms, which is very advantageous for their acquisition of phagocytic functions upon activation. We also determine the elastic constants of pure cell membrane, with no attached cytoskeleton. For all cell types, the presence of F-actin within tethers, contrary to conventional wisdom, is confirmed. Our findings suggest the existence of a close connection between membrane elastic constants and cell function.

  20. Elastic and inelastic electron and muon scattering

    International Nuclear Information System (INIS)

    Hand, L.N.

    1977-01-01

    The current status of experiments in the field of elastic and inelastic electron and muon scattering is discussed. The talk is divided into discussions of the single arm inclusive experiments at SLAC and Fermilab; the multiparticle inclusive experiments at SLAC, Fermilab und Cornell, and a description of selected results from exclusive channel measurements on electroproduced final states. (orig.) [de

  1. Relativistic elasticity of stationary fluid branes

    DEFF Research Database (Denmark)

    Armas, J.; Obers, N.A.

    2013-01-01

    under certain conditions that a given stationary fluid configuration living on a dynamical surface of vanishing thickness and satisfying locally the first law of thermodynamics will behave like an elastic brane when the surface is subject to small deformations. These results, which are independent...

  2. Robotic edge machining using elastic abrasive tool

    Science.gov (United States)

    Sidorova, A. V.; Semyonov, E. N.; Belomestnykh, A. S.

    2018-03-01

    The article describes a robotic center designed for automation of finishing operations, and analyzes technological aspects of an elastic abrasive tool applied for edge machining. Based on the experimental studies, practical recommendations on the application of the robotic center for finishing operations were developed.

  3. Elastic behaviour of North Sea chalk

    DEFF Research Database (Denmark)

    Gommesen, Lars; Fabricius, Ida Lykke; Mukerji, T.

    2007-01-01

    -consistent approximation, which here represents the unrelaxed scenario where the pore spaces of the rock are assumed to be isolated, and the Gassmann theory, which assumes that pore spaces are connected, as tools for predicting the effect of hydrocarbons from the elastic properties of brine-saturated North Sea reservoir...

  4. Thickness dependence of nanofilm elastic modulus

    Czech Academy of Sciences Publication Activity Database

    Fedorchenko, Alexander I.; Wang, A. B.; Cheng, H.H.

    2009-01-01

    Roč. 94, č. 15 (2009), s. 152111-152113 ISSN 0003-6951 Institutional research plan: CEZ:AV0Z20760514 Keywords : nanofilm * elastic modulus * thickness dependence Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.554, year: 2009 http://link.aip.org/link/?APPLAB/94/152111/1

  5. Structural, elastic, optoelectronic and magnetic properties of ...

    Indian Academy of Sciences (India)

    2017-09-22

    Sep 22, 2017 ... 1Laboratoire de Physique Quantique de la Matière et de la ... 5Department of Physics and Astronomy, College of Science, King Saud ... elastic moduli, CdHo2S4 is mechanically stable with a ductile nature and a noticeable.

  6. Growth on elastic silicone substrate elicits a partial myogenic response in periodontal ligament derived stem cells

    Directory of Open Access Journals (Sweden)

    Daniel Pelaez

    2016-12-01

    Full Text Available The processes of cellular differentiation and phenotypic maintenance can be influenced by stimuli from a variety of different factors. One commonly overlooked factor is the mechanical properties of the growth substrate in which stem cells are maintained or differentiated down various lineages. Here we explored the effect that growth on an elastic silicone substrate had on the myogenic expression and cytoskeletal morphology of periodontal ligament derived stem cells. Cells were grown on either collagen I coated tissue culture polystyrene plates or collagen I coated elastic silicone membranes for a period of 4 days without further induction from soluble factors in the culture media. Following the 4-day growth, gene expression and immunohistochemical analysis for key cardiomyogenic markers was performed along with a morphological assessment of cytoskeletal organization. Results show that cells grown on the elastic substrate significantly upregulate key markers associated with contractile activity in muscle tissues. Namely, the myosin light chain polypeptides 2 and 7, as well as the myosin heavy chain polypeptide 7 genes underwent a statistically significant upregulation in the cells grown on elastic silicone membranes. Similarly, the cells on the softer elastic substrate stained positive for both sarcomeric actin and cardiac troponin t proteins following just 4 days of growth on the softer material. Cytoskeletal analysis showed that substrate stiffness had a marked effect on the organization and distribution of filamentous actin fibers within the cell body. Growth on silicone membranes produced flatter and shorter cellular morphologies with filamentous actin fibers projecting anisotropically throughout the cell body. These results demonstrate how crucial the mechanical properties of the growth substrate of cells can be on the ultimate cellular phenotype. These observations highlight the need to further optimize differentiation protocols to enhance

  7. Tissue irradiator

    International Nuclear Information System (INIS)

    Hungate, F.P.; Riemath, W.F.; Bunnell, L.R.

    1975-01-01

    A tissue irradiator is provided for the in-vivo irradiation of body tissue. The irradiator comprises a radiation source material contained and completely encapsulated within vitreous carbon. An embodiment for use as an in-vivo blood irradiator comprises a cylindrical body having an axial bore therethrough. A radioisotope is contained within a first portion of vitreous carbon cylindrically surrounding the axial bore, and a containment portion of vitreous carbon surrounds the radioisotope containing portion, the two portions of vitreous carbon being integrally formed as a single unit. Connecting means are provided at each end of the cylindrical body to permit connections to blood-carrying vessels and to provide for passage of blood through the bore. In a preferred embodiment, the radioisotope is thulium-170 which is present in the irradiator in the form of thulium oxide. A method of producing the preferred blood irradiator is also provided, whereby nonradioactive thulium-169 is dispersed within a polyfurfuryl alcohol resin which is carbonized and fired to form the integral vitreous carbon body and the device is activated by neutron bombardment of the thulium-169 to produce the beta-emitting thulium-170

  8. Negative stiffness honeycombs as tunable elastic metamaterials

    Science.gov (United States)

    Goldsberry, Benjamin M.; Haberman, Michael R.

    2018-03-01

    Acoustic and elastic metamaterials are media with a subwavelength structure that behave as effective materials displaying atypical effective dynamic properties. These material systems are of interest because the design of their sub-wavelength structure allows for direct control of macroscopic wave dispersion. One major design limitation of most metamaterial structures is that the dynamic response cannot be altered once the microstructure is manufactured. However, the ability to modify wave propagation in the metamaterial with an external stimulus is highly desirable for numerous applications and therefore remains a significant challenge in elastic metamaterials research. In this work, a honeycomb structure composed of a doubly periodic array of curved beams, known as a negative stiffness honeycomb (NSH), is analyzed as a tunable elastic metamaterial. The nonlinear static elastic response that results from large deformations of the NSH unit cell leads to a large variation in linear elastic wave dispersion associated with infinitesimal motion superposed on the externally imposed pre-strain. A finite element model is utilized to model the static deformation and subsequent linear wave motion at the pre-strained state. Analysis of the slowness surface and group velocity demonstrates that the NSH exhibits significant tunability and a high degree of anisotropy which can be used to guide wave energy depending on static pre-strain levels. In addition, it is shown that partial band gaps exist where only longitudinal waves propagate. The NSH therefore behaves as a meta-fluid, or pentamode metamaterial, which may be of use for applications of transformation elastodynamics such as cloaking and gradient index lens devices.

  9. Elastic versus acoustic inversion for marine surveys

    Science.gov (United States)

    Mora, Peter; Wu, Zedong

    2018-04-01

    Full Wavefield Inversion (FWI) is a powerful and elegant approach for seismic imaging that is on the way to becoming the method of choice when processing exploration or global seismic data. In the case of processing marine survey data, one may be tempted to assume acoustic FWI is sufficient given that only pressure waves exist in the water layer. In this paper, we pose the question as to whether or not in theory - at least for a hard water bottom case - it should be possible to resolve the shear modulus or S-wave velocity in a marine setting using large offset data. We therefore conduct numerical experiments with idealized marine data calculated with the elastic wave equation. We study two cases, FWI of data due to a diffractor model, and FWI of data due to a fault model. We find that at least in idealized situation, elastic FWI of hard waterbottom data is capable of resolving between the two Lamé parameters λ and μ. Another numerical experiment with a soft waterbottom layer gives the same result. In contrast, acoustic FWI of the synthetic elastic data results in a single image of the first Lamé parameter λ which contains severe artefacts for diffraction data and noticable artefacts for layer reflection data. Based on these results, it would appear that at least, inversions of large offset marine data should be fully elastic rather than acoustic unless it has been demonstrated that for the specific case in question (offsets, model and water depth, practical issues such as soft sediment attenuation of shear waves or computational time), that an acoustic only inversion provides a reasonably good quality of image comparable to that of an elastic inversion. Further research with real data is required to determine the degree to which practical issues such as shear wave attenuation in soft sediments may affect this result.

  10. Elastic versus acoustic inversion for marine surveys

    KAUST Repository

    Mora, Peter

    2018-04-24

    Full Wavefield Inversion (FWI) is a powerful and elegant approach for seismic imaging that is on the way to becoming the method of choice when processing exploration or global seismic data. In the case of processing marine survey data, one may be tempted to assume acoustic FWI is sufficient given that only pressure waves exist in the water layer. In this paper, we pose the question as to whether or not in theory – at least for a hard water bottom case – it should be possible to resolve the shear modulus or S-wave velocity in a marine setting using large offset data. We therefore conduct numerical experiments with idealized marine data calculated with the elastic wave equation. We study two cases, FWI of data due to a diffractor model, and FWI of data due to a fault model. We find that at least in idealized situation, elastic FWI of hard waterbottom data is capable of resolving between the two Lamé parameters λ and μ. Another numerical experiment with a soft waterbottom layer gives the same result. In contrast, acoustic FWI of the synthetic elastic data results in a single image of the first Lamé parameter λ which contains severe artefacts for diffraction data and noticable artefacts for layer reflection data. Based on these results, it would appear that at least, inversions of large offset marine data should be fully elastic rather than acoustic unless it has been demonstrated that for the specific case in question (offsets, model and water depth, practical issues such as soft sediment attenuation of shear waves or computational time), that an acoustic only inversion provides a reasonably good quality of image comparable to that of an elastic inversion. Further research with real data is required to determine the degree to which practical issues such as shear wave attenuation in soft sediments may affect this result.

  11. Elasticity problems in domains with nonsmooth boundaries

    International Nuclear Information System (INIS)

    Esparza, David

    2001-01-01

    In the present work we study the behaviour of elastic stress fields in domains with non-regular boundaries. We consider three-dimensional problems in elastic media with thin conical defects (inclusions or cavities) and analyse the stress singularity at their vertices. To construct asymptotic expansions for the stress and displacement fields in terms of a small parameter ε related to the 'thickness' of the defect, we employ a technique based on the work by Kondrat'ev, Maz'ya, Nazarov and Plamenevskii. We first study the stress distribution in an elastic body with a thin conical notch. We derive an asymptotic representation for the stress singularity exponent by reducing the original problem to a spectral problem for a 9x9 matrix. The elements of this matrix are found to depend upon the geometry of the cross-section of the notch and the elastic properties of the medium. We specify the sets of eigenvalues and the corresponding eigenvectors for a circular, elliptical, 'triangular' and 'square' cross-section, and show that the strongest singularity is associated with the 'triangular' cross-section, and is generated by a non-axisymmetric load. We then analyse the stress distribution near a thin conical inclusion which is allowed to slide freely along its axis. We derive the representation for the stress singularity exponent for the case of a circular conical inclusion whose elastic properties differ from those of the medium. In the last chapter we study the stress distribution in the vicinity of a thin 'coated' conical inclusion. We show that a soft thin coating (perfectly bonded to the inclusion and the surrounding material) can be replaced by a so-called linear interface at which the normal displacement is discontinuous, and the stresses are proportional to the 'jump' in the normal displacement across the coating. We analyse the effect of the properties of the coating on the stress singularity exponent and compare the results with those for a perfectly bonded

  12. Elastic interaction of hydrogen atoms on graphene: A multiscale approach from first principles to continuum elasticity

    Science.gov (United States)

    Branicio, Paulo S.; Vastola, Guglielmo; Jhon, Mark H.; Sullivan, Michael B.; Shenoy, Vivek B.; Srolovitz, David J.

    2016-10-01

    The deformation of graphene due to the chemisorption of hydrogen atoms on its surface and the long-range elastic interaction between hydrogen atoms induced by these deformations are investigated using a multiscale approach based on first principles, empirical interactions, and continuum modeling. Focus is given to the intrinsic low-temperature structure and interactions. Therefore, all calculations are performed at T =0 , neglecting possible temperature or thermal fluctuation effects. Results from different methods agree well and consistently describe the local deformation of graphene on multiple length scales reaching 500 Å . The results indicate that the elastic interaction mediated by this deformation is significant and depends on the deformation of the graphene sheet both in and out of plane. Surprisingly, despite the isotropic elasticity of graphene, within the linear elastic regime, atoms elastically attract or repel each other depending on (i) the specific site they are chemisorbed; (ii) the relative position of the sites; (iii) and if they are on the same or on opposite surface sides. The interaction energy sign and power-law decay calculated from molecular statics agree well with theoretical predictions from linear elasticity theory, considering in-plane or out-of-plane deformations as a superposition or in a coupled nonlinear approach. Deviations on the exact power law between molecular statics and the linear elastic analysis are evidence of the importance of nonlinear effects on the elasticity of monolayer graphene. These results have implications for the understanding of the generation of clusters and regular formations of hydrogen and other chemisorbed atoms on graphene.

  13. Numerical estimate of fracture parameters under elastic and elastic-plastic conditions

    International Nuclear Information System (INIS)

    Soba, Alejandro; Denis, Alicia C.

    2003-01-01

    The importance of the stress intensity factor K in the elastic fracture analysis is well known. In this work three methods are developed to estimate the parameter K I , corresponding to the normal loading mode, employing the finite elements method. The elastic-plastic condition is also analyzed, where the line integral J is the relevant parameter. Two cases of interest are studied: sample with a crack in its center and tubes with internal pressure. (author)

  14. Measurement of gastrocnemius muscle elasticity by shear wave elastography: association with passive ankle joint stiffness and sex differences.

    Science.gov (United States)

    Chino, Kentaro; Takahashi, Hideyuki

    2016-04-01

    Passive joint stiffness is an important quantitative measure of flexibility, but is affected by muscle volume and all of the anatomical structures located within and over the joint. Shear wave elastography can assess muscle elasticity independent of the influences of muscle volume and the other nearby anatomical structures. We determined how muscle elasticity, as measured using shear wave elastography, is associated with passive joint stiffness and patient sex. Twenty-six healthy men (24.4 ± 5.9 years) and 26 healthy women (25.2 ± 4.8 years) participated in this study. The passive ankle joint stiffness and tissue elasticity of the medial gastrocnemius (MG) were quantified with the ankle in 30° plantar flexion (PF), a neutral anatomical position (NE), and 20° dorsiflexion (DF). No significant difference in passive joint stiffness by sex was observed with the ankle in PF, but significantly greater passive ankle joint stiffness in men than in women was observed in NE and DF. The MG elasticity was not significantly associated with joint stiffness in PF or NE, but it was significantly associated with joint stiffness in DF. There were no significant differences in MG elasticity by sex at any ankle position. Muscle elasticity, measured independent of the confounding effects of muscle volume and the other nearby anatomical structures, is associated with passive joint stiffness in the joint position where the muscle is sufficiently lengthened, but does not vary by sex in any joint position tested.

  15. Greater Reduction of Balance as a Result of Increased Plantar Fascia Elasticity at Ovulation during the Menstrual Cycle.

    Science.gov (United States)

    Petrofsky, Jerrold; Lee, Haneul

    2015-11-01

    One of the sexual hormones, estrogen, increases elasticity of human connective tissue such as the anterior cruciate ligament during the menstrual cycle in women. In the present investigation, the plantar fascia was investigated to see if there is a difference in elasticity with the menstrual cycle. Fifteen young healthy females in the age range of 18-35 years old with a regular menstrual cycle were tested twice throughout one full menstrual cycle; once during the early follicular phases and once at ovulation. Foot length, while standing on both feet and one foot were used to assess plantar fascia elasticity, ultrasound measured plantar fascia thickness while lying and standing, and posture sway and tremor using a balance platform during 8 different balance tests were assessed to see the impact of elasticity changes. Foot length increased significantly at ovulation compared to menstruation when standing on two feet (p = 0.03) and standing on one foot (p plantar fascia in thinning per kilogram weight applied to the foot at ovulation compared to menstruation (p = 0.014). Associated with this increase in elasticity at ovulation, there was a reduction in balance in the most difficult balance tasks and an increase in tremor during ovulation (p Plantar fascia elasticity change during the menstrual cycle might have effects on posture sway and tremor, which could have a potential risk of falling. Therefore, healthy professionals working with young female adults should recognize these physiological effects.

  16. Leadership Elasticity Enhancing Style-Flex for Leadership Equilibrium

    Science.gov (United States)

    Rajbhandari, Mani Man Singh

    2017-01-01

    Leadership elasticity enhances leadership style flexibility and mobility to enable educational leaders to maintain appropriate leadership equilibrium. The essential of leadership elasticity contributes towards organizational effectiveness by followership's maintenance through appropriate expansion and contraction of relations and task behavioural…

  17. Elastic electron scattering from the DNA bases: cytosine and thymine

    International Nuclear Information System (INIS)

    Colyer, C J; Bellm, S M; Lohmanny, B; Blanco, F; Garcia, G

    2012-01-01

    Relative elastic differential cross sections for elastic scattering from cytosine and thymine have been measured using the crossed beam method. The experimental data are compared with theoretical cross sections calculated by the screen corrected additivity rule method.

  18. Controlling elastic waves with small phononic crystals containing rigid inclusions

    KAUST Repository

    Peng, Pai

    2014-05-01

    We show that a two-dimensional elastic phononic crystal comprising rigid cylinders in a solid matrix possesses a large complete band gap below a cut-off frequency. A mechanical model reveals that the band gap is induced by negative effective mass density, which is affirmed by an effective medium theory based on field averaging. We demonstrate, by two examples, that such elastic phononic crystals can be utilized to design small devices to control low-frequency elastic waves. One example is a waveguide made of a two-layer anisotropic elastic phononic crystal, which can guide and bend elastic waves with wavelengths much larger than the size of the waveguide. The other example is the enhanced elastic transmission of a single-layer elastic phononic crystal loaded with solid inclusions. The effective mass density and reciprocal of the modulus of the single-layer elastic phononic crystal are simultaneously near zero. © CopyrightEPLA, 2014.

  19. The elastic theory of a single DNA molecule

    Indian Academy of Sciences (India)

    methods and Monte Carlo simulations to understand the entropic elasticity, ... DNA; elastic theory; stacking interaction; supercoiling; hairpin-coil transition. .... the probability distribution of t and ϕ along the DNA chain [14,15], is governed by.

  20. Derivation of capture and reaction cross sections from experimental quasi-elastic and elastic backscattering probabilities

    International Nuclear Information System (INIS)

    Sargsyan, V.V.; Adamian, G.G.; Antonenko, N.V.; Gomes, P.R.S.

    2014-01-01

    We suggest simple and useful methods to extract reaction and capture (fusion) cross sections from the experimental elastic and quasi-elastic backscattering data.The direct measurement of the reaction or capture (fusion) cross section is a difficult task since it would require the measurement of individual cross sections of many reaction channels, and most of them could be reached only by specific experiments. This would require different experimental setups not always available at the same laboratory and, consequently, such direct measurements would demand a large amount of beam time and would take probably some years to be reached. Because of that, the measurements of elastic scattering angular distributions that cover full angular ranges and optical model analysis have been used for the determination of reaction cross sections. This traditional method consists in deriving the parameters of the complex optical potentials which fit the experimental elastic scattering angular distributions and then of deriving the reaction cross sections predicted by these potentials. Even so, both the experimental part and the analysis of this latter method are not so simple. In the present work we present a much simpler method to determine reaction and capture (fusion) cross sections. It consists of measuring only elastic or quasi-elastic scattering at one backward angle, and from that, the extraction of the reaction or capture cross sections can easily be performed. (author)

  1. Sonoelastography can be used to monitor the restoration of Achilles tendon elasticity after injury.

    Science.gov (United States)

    Gehmert, S; Jung, E M; Kügler, T; Klein, S; Gehmert, S; Zeitler, K; Loibl, M; Prantl, L

    2012-12-01

    The aim of the current study was to evaluate an ultrasound approach for depicting elastic recovery after stem cell application on injured Achilles tendons. A rabbit Achilles tendon injury model was used and randomized hind limbs received an extracellular matrix either with autologous mesenchymal stem cells (group 2, n = 6) or without (group 3, n = 6). The cells were harvested from the rabbits' nuchal fat body. Untreated Achilles tendons (group 1, n = 6) served as controls. Specimens were harvested after 8 weeks and analyzed longitudinally for elasticity using a high resolution 6-15 MHz matrix linear probe. For each tendon, real-time color-coded sonoelastography sequences were recorded for 20 seconds and 10 color histogram frames were obtained. Defined regions of interest (ROIs) were placed on the injury (n = 3) and on the adjacent uninjured tendon tissue (n = 3). In total, 180 measurements were obtained for semi-quantitative analysis. Repeated measures ANOVA demonstrated a higher elasticity for the stem cell-seeded matrix (group 2) in comparison to the unseeded matrix (group 3) (p tendon tissue treated with stem cell-seeded matrix (group 2) and the uninjured Achilles tendons (group 1) (p > 0.05). Moreover, no differences were found between the measurements at different points in time (p > 0.05). Our results indicate that autologous mesenchymal stem cell application successfully restores the mechanical properties of injured tendon tissue. Furthermore, sonoelastography makes it possible to monitor the elasticity of injured Achilles tendons. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Fabrication of a biomimetic elastic intervertebral disk scaffold using additive manufacturing

    International Nuclear Information System (INIS)

    Whatley, Benjamin R; Kuo, Jonathan; Shuai, Cijun; Wen Xuejun; Damon, Brooke J

    2011-01-01

    A custom-designed three-dimensional additive manufacturing device was developed to fabricate scaffolds for intervertebral disk (IVD) regeneration. This technique integrated a computer with a device capable of 3D movement allowing for precise motion and control over the polymer scaffold resolution. IVD scaffold structures were designed using computer-aided design to resemble the natural IVD structure. Degradable polyurethane (PU) was used as an elastic scaffold construct to mimic the elastic nature of the native IVD tissue and was deposited at a controlled rate using ultra-fine micropipettes connected to a syringe pump. The elastic PU was extruded directly onto a collecting substrate placed on a freezing stage. The three-dimensional movement of the computer-controlled device combined with the freezing stage enabled precise control of polymer deposition using extrusion. The addition of the freezing stage increased the polymer solution viscosity and hardened the polymer solution as it was extruded out of the micropipette tip. This technique created scaffolds with excellent control over macro- and micro-structure to influence cell behavior, specifically for cell adhesion, proliferation, and alignment. Concentric lamellae were printed at a high resolution to mimic the native shape and structure of the IVD. Seeded cells aligned along the concentric lamellae and acquired cell morphology similar to native tissue in the outer portion of the IVD. The fabricated scaffolds exhibited elastic behavior during compressive and shear testing, proving that the scaffolds could support loads with proper fatigue resistance without permanent deformation. Additionally, the mechanical properties of the scaffolds were comparable to those of native IVD tissue.

  3. Fabrication of a biomimetic elastic intervertebral disk scaffold using additive manufacturing.

    Science.gov (United States)

    Whatley, Benjamin R; Kuo, Jonathan; Shuai, Cijun; Damon, Brooke J; Wen, Xuejun

    2011-03-01

    A custom-designed three-dimensional additive manufacturing device was developed to fabricate scaffolds for intervertebral disk (IVD) regeneration. This technique integrated a computer with a device capable of 3D movement allowing for precise motion and control over the polymer scaffold resolution. IVD scaffold structures were designed using computer-aided design to resemble the natural IVD structure. Degradable polyurethane (PU) was used as an elastic scaffold construct to mimic the elastic nature of the native IVD tissue and was deposited at a controlled rate using ultra-fine micropipettes connected to a syringe pump. The elastic PU was extruded directly onto a collecting substrate placed on a freezing stage. The three-dimensional movement of the computer-controlled device combined with the freezing stage enabled precise control of polymer deposition using extrusion. The addition of the freezing stage increased the polymer solution viscosity and hardened the polymer solution as it was extruded out of the micropipette tip. This technique created scaffolds with excellent control over macro- and micro-structure to influence cell behavior, specifically for cell adhesion, proliferation, and alignment. Concentric lamellae were printed at a high resolution to mimic the native shape and structure of the IVD. Seeded cells aligned along the concentric lamellae and acquired cell morphology similar to native tissue in the outer portion of the IVD. The fabricated scaffolds exhibited elastic behavior during compressive and shear testing, proving that the scaffolds could support loads with proper fatigue resistance without permanent deformation. Additionally, the mechanical properties of the scaffolds were comparable to those of native IVD tissue.

  4. Making Cloud-based Systems Elasticity Testing Reproducible

    OpenAIRE

    Albonico , Michel; Mottu , Jean-Marie; Sunyé , Gerson; Alvares , Frederico

    2017-01-01

    International audience; Elastic cloud infrastructures vary computational resources at runtime, i. e., elasticity, which is error-prone. That makes testing throughout elasticity crucial for those systems. Those errors are detected thanks to tests that should run deterministically many times all along the development. However, elasticity testing reproduction requires several features not supported natively by the main cloud providers, such as Amazon EC2. We identify three requirements that we c...

  5. Cell wall elasticity: I. A critique of the bulk elastic modulus approach and an analysis using polymer elastic principles

    Science.gov (United States)

    Wu, H. I.; Spence, R. D.; Sharpe, P. J.; Goeschl, J. D.

    1985-01-01

    The traditional bulk elastic modulus approach to plant cell pressure-volume relations is inconsistent with its definition. The relationship between the bulk modulus and Young's modulus that forms the basis of their usual application to cell pressure-volume properties is demonstrated to be physically meaningless. The bulk modulus describes stress/strain relations of solid, homogeneous bodies undergoing small deformations, whereas the plant cell is best described as a thin-shelled, fluid-filled structure with a polymer base. Because cell walls possess a polymer structure, an alternative method of mechanical analysis is presented using polymer elasticity principles. This initial study presents the groundwork of polymer mechanics as would be applied to cell walls and discusses how the matrix and microfibrillar network induce nonlinear stress/strain relationships in the cell wall in response to turgor pressure. In subsequent studies, these concepts will be expanded to include anisotropic expansion as regulated by the microfibrillar network.

  6. Lung tissue mechanics as an emergent phenomenon.

    Science.gov (United States)

    Suki, Béla; Bates, Jason H T

    2011-04-01

    The mechanical properties of lung parenchymal tissue are both elastic and dissipative, as well as being highly nonlinear. These properties cannot be fully understood, however, in terms of the individual constituents of the tissue. Rather, the mechanical behavior of lung tissue emerges as a macroscopic phenomenon from the interactions of its microscopic components in a way that is neither intuitive nor easily understood. In this review, we first consider the quasi-static mechanical behavior of lung tissue and discuss computational models that show how smooth nonlinear stress-strain behavior can arise through a percolation-like process in which the sequential recruitment of collagen fibers with increasing strain causes them to progressively take over the load-bearing role from elastin. We also show how the concept of percolation can be used to link the pathologic progression of parenchymal disease at the micro scale to physiological symptoms at the macro scale. We then examine the dynamic mechanical behavior of lung tissue, which invokes the notion of tissue resistance. Although usually modeled phenomenologically in terms of collections of springs and dashpots, lung tissue viscoelasticity again can be seen to reflect various types of complex dynamic interactions at the molecular level. Finally, we discuss the inevitability of why lung tissue mechanics need to be complex.

  7. Parameter Optimisation for the Behaviour of Elastic Models over Time

    DEFF Research Database (Denmark)

    Mosegaard, Jesper

    2004-01-01

    Optimisation of parameters for elastic models is essential for comparison or finding equivalent behaviour of elastic models when parameters cannot simply be transferred or converted. This is the case with a large range of commonly used elastic models. In this paper we present a general method tha...

  8. Adaptation of generalized Hill inequalities to anisotropic elastic ...

    African Journals Online (AJOL)

    user

    Thallium manganese chloride(TIMnCl 3 ). 101.4. 16.5. 32.2. 5.2 For Isotropic Media. For some materials, it is possible to make approaches from cubic symmetry to isotropic symmetry. With cubic symmetry, three independent elastic constants are needed. If the medium is elastically isotropic, the elastic properties are ...

  9. Theory of the change of elastic constants by interstitials

    International Nuclear Information System (INIS)

    Breuer, N.; Dederichs, P.H.; Lehmann, C.; Leibfried, G.; Scholz, A.

    1975-01-01

    The theory of the change of elastic constants by point-defects, in particular by interstitials, is briefly summarized. The typical effects of spring changes in a defect lattice on the elastic data are discussed qualitatively. Numerical results for the change of elastic constants by self-interstitials and vacancies are given and compared with experimental data for Cu and Al

  10. Consumer brand choice: individual and group analyses of demand elasticity.

    Science.gov (United States)

    Oliveira-Castro, Jorge M; Foxall, Gordon R; Schrezenmaier, Teresa C

    2006-03-01

    Following the behavior-analytic tradition of analyzing individual behavior, the present research investigated demand elasticity of individual consumers purchasing supermarket products, and compared individual and group analyses of elasticity. Panel data from 80 UK consumers purchasing 9 product categories (i.e., baked beans, biscuits, breakfast cereals, butter, cheese, fruit juice, instant coffee, margarine and tea) during a 16-week period were used. Elasticity coefficients were calculated for individual consumers with data from all or only 1 product category (intra-consumer elasticities), and for each product category using all data points from all consumers (overall product elasticity) or 1 average data point per consumer (interconsumer elasticity). In addition to this, split-sample elasticity coefficients were obtained for each individual with data from all product categories purchased during weeks 1 to 8 and 9 to 16. The results suggest that: 1) demand elasticity coefficients calculated for individual consumers purchasing supermarket food products are compatible with predictions from economic theory and behavioral economics; 2) overall product elasticities, typically employed in marketing and econometric research, include effects of interconsumer and intraconsumer elasticities; 3) when comparing demand elasticities of different product categories, group and individual analyses yield similar trends; and 4) individual differences in demand elasticity are relatively consistent across time, but do not seem to be consistent across products. These results demonstrate the theoretical, methodological, and managerial relevance of investigating the behavior of individual consumers.

  11. Multiscale mechanics of hierarchical structure/property relationships in calcified tissues and tissue/material interfaces

    International Nuclear Information System (INIS)

    Katz, J. Lawrence; Misra, Anil; Spencer, Paulette; Wang, Yong; Bumrerraj, Sauwanan; Nomura, Tsutomu; Eppell, Steven J.; Tabib-Azar, Massood

    2007-01-01

    This paper presents a review plus new data that describes the role hierarchical nanostructural properties play in developing an understanding of the effect of scale on the material properties (chemical, elastic and electrical) of calcified tissues as well as the interfaces that form between such tissues and biomaterials. Both nanostructural and microstructural properties will be considered starting with the size and shape of the apatitic mineralites in both young and mature bovine bone. Microstructural properties for human dentin and cortical and trabecular bone will be considered. These separate sets of data will be combined mathematically to advance the effects of scale on the modeling of these tissues and the tissue/biomaterial interfaces as hierarchical material/structural composites. Interfacial structure and properties to be considered in greatest detail will be that of the dentin/adhesive (d/a) interface, which presents a clear example of examining all three material properties, (chemical, elastic and electrical). In this case, finite element modeling (FEA) was based on the actual measured values of the structure and elastic properties of the materials comprising the d/a interface; this combination provides insight into factors and mechanisms that contribute to premature failure of dental composite fillings. At present, there are more elastic property data obtained by microstructural measurements, especially high frequency ultrasonic wave propagation (UWP) and scanning acoustic microscopy (SAM) techniques. However, atomic force microscopy (AFM) and nanoindentation (NI) of cortical and trabecular bone and the dentin-enamel junction (DEJ) among others have become available allowing correlation of the nanostructural level measurements with those made on the microstructural level

  12. The elastic free energy of a tandem modular protein under force.

    Science.gov (United States)

    Valle-Orero, Jessica; Eckels, Edward C; Stirnemann, Guillaume; Popa, Ionel; Berkovich, Ronen; Fernandez, Julio M

    2015-05-01

    Recent studies have provided a theoretical framework for including entropic elasticity in the free energy landscape of proteins under mechanical force. Accounting for entropic elasticity using polymer physics models has helped explain the hopping behavior seen in single molecule experiments in the low force regime. Here, we expand on the construction of the free energy of a single protein domain under force proposed by Berkovich et al. to provide a free energy landscape for N tandem domains along a continuous polypeptide. Calculation of the free energy of individual domains followed by their concatenation provides a continuous free energy landscape whose curvature is dominated by the worm-like chain at forces below 20 pN. We have validated our free energy model using Brownian dynamics and reproduce key features of protein folding. This free energy model can predict the effects of changes in the elastic properties of a multidomain protein as a consequence of biological modifications such as phosphorylation or the formation of disulfide bonds. This work lays the foundations for the modeling of tissue elasticity, which is largely determined by the properties of tandem polyproteins. Copyright © 2015. Published by Elsevier Inc.

  13. Fabrication, characterization, and biocompatibility assessment of a novel elastomeric nanofibrous scaffold: A potential scaffold for soft tissue engineering

    DEFF Research Database (Denmark)

    Shamirzaei Jeshvaghani, Elham; Ghasemi-Mobarakeh, Laleh; Mansurnezhad, Reza

    2017-01-01

    With regard to flexibility and strength properties requirements of soft biological tissue, elastomeric materials could be more beneficial in soft tissue engineering applications. The present work investigates the use of an elastic polymer, (polycaprolactone fumarate [PCLF]), for fabricating...... experiments and its application for engineering of soft tissues subjected to in vivo cyclic mechanical stresses....

  14. Plutonium Elastic Moduli, Electron Localization, and Temperature

    International Nuclear Information System (INIS)

    Migliori, Albert; Mihut-Stroe, Izabella; Betts, Jon B.

    2008-01-01

    In almost all materials, compression is accompanied naturally by stiffening. Even in materials with zero or negative thermal expansion, where warming is accompanied by volume contraction it is the volume change that primarily controls elastic stiffness. Not so in the metal plutonium. In plutonium, alloying with gallium can change the sign of thermal expansion, but for the positive thermal- expansion monoclinic phase as well as the face-centered-cubic phase with either sign of thermal expansion, and the orthorhombic phase, recent measurements of elastic moduli show soften on warming by an order of magnitude more than expected, the shear and compressional moduli track, and volume seems irrelevant. These effects point toward a novel mechanism for electron localization, and have important implication for the pressure dependence of the bulk compressibility. (authors)

  15. Anticavitation and Differential Growth in Elastic Shells

    KAUST Repository

    Moulton, Derek E.

    2010-07-22

    Elastic anticavitation is the phenomenon of a void in an elastic solid collapsing on itself. Under the action of mechanical loading alone typical materials do not admit anticavitation. We study the possibility of anticavitation as a consequence of an imposed differential growth. Working in the geometry of a spherical shell, we seek radial growth functions which cause the shell to deform to a solid sphere. It is shown, surprisingly, that most material models do not admit full anticavitation, even when infinite growth or resorption is imposed at the inner surface of the shell. However, void collapse can occur in a limiting sense when radial and circumferential growth are properly balanced. Growth functions which diverge or vanish at a point arise naturally in a cumulative growth process. © 2010 Springer Science+Business Media B.V.

  16. Morphoelasticity: A theory of elastic growth

    KAUST Repository

    Goriely, Alain; Moulton, Derek

    2011-01-01

    This chapter is concerned with the modelling of growth processes in the framework of continuum mechanics and nonlinear elasticity. It begins by considering growth and deformation in a one-dimensional setting, illustrating the key relationship between growth, the elastic response of the material, and the generation of residual stresses. The general three-dimensional theory of morphoelasticity is then developed from conservation of mass and momentum balance equations. In the formulation, the multiplicative decomposition of the deformation tensor, the standard approach in morphoelasticity, is derived in a new way. A discussion of continuous growth is also included. The chapter concludes by working through a sample problem of a growing cylindrical tube. A stability analysis is formulated, and the effect of growth on mucosal folding, a commonly seen instability in biological tubes, is demonstrated.

  17. Elastic softness of hybrid lead halide perovskites

    KAUST Repository

    Ferreira, A. C.

    2018-01-26

    Much recent attention has been devoted towards unravelling the microscopic optoelectronic properties of hybrid organic-inorganic perovskites (HOP). Here we investigate by coherent inelastic neutron scattering spectroscopy and Brillouin light scattering, low frequency acoustic phonons in four different hybrid perovskite single crystals: MAPbBr3, FAPbBr3, MAPbI3 and α-FAPbI3 (MA: methylammonium, FA: formamidinium). We report a complete set of elastic constants caracterized by a very soft shear modulus C44. Further, a tendency towards an incipient ferroelastic transition is observed in FAPbBr3. We observe a systematic lower sound group velocity in the technologically important iodide-based compounds compared to the bromide-based ones. The findings suggest that low thermal conductivity and hot phonon bottleneck phenomena are expected to be enhanced by low elastic stiffness, particularly in the case of the ultrasoft α-FAPbI3.

  18. Morphoelasticity: A theory of elastic growth

    KAUST Repository

    Goriely, Alain

    2011-10-11

    This chapter is concerned with the modelling of growth processes in the framework of continuum mechanics and nonlinear elasticity. It begins by considering growth and deformation in a one-dimensional setting, illustrating the key relationship between growth, the elastic response of the material, and the generation of residual stresses. The general three-dimensional theory of morphoelasticity is then developed from conservation of mass and momentum balance equations. In the formulation, the multiplicative decomposition of the deformation tensor, the standard approach in morphoelasticity, is derived in a new way. A discussion of continuous growth is also included. The chapter concludes by working through a sample problem of a growing cylindrical tube. A stability analysis is formulated, and the effect of growth on mucosal folding, a commonly seen instability in biological tubes, is demonstrated.

  19. Mathematical methods in electro-magneto-elasticity

    CERN Document Server

    Bardzokas, DI; Filshtinsky, LA

    2007-01-01

    The mechanics of Coupled Fields is a discipline at the edge of modern research connecting Continuum Mechanics with Solid State Physics. It integrates the Mechanics of Continuous Media, Heat Conductivity and the theory of Electromagnetism that are usually studied separately. For an accurate description of the influence of static and dynamic loadings, high temperatures and strong electromagnetic fields in elastic media and constructive installations, a new approach is required; an approach that has the potential to establish a synergism between the above mentioned fields. Throughout the book a vast number of problems are considered: two-dimensional problems of electro-magneto-elasticity as well as static and dynamical problems for piecewise homogenous compound piezoelectric plates weakened by cracks and openings. The boundary conditions, the constructive equations and the mathematical methods for their solution are thoroughly presented, so that the reader can get a clear quantitative and qualitative understandi...

  20. Relativistic elasticity of stationary fluid branes

    Science.gov (United States)

    Armas, Jay; Obers, Niels A.

    2013-02-01

    Fluid mechanics can be formulated on dynamical surfaces of arbitrary codimension embedded in a background space-time. This has been the main object of study of the blackfold approach in which the emphasis has primarily been on stationary fluid configurations. Motivated by this approach we show under certain conditions that a given stationary fluid configuration living on a dynamical surface of vanishing thickness and satisfying locally the first law of thermodynamics will behave like an elastic brane when the surface is subject to small deformations. These results, which are independent of the number of space-time dimensions and of the fluid arising from a gravitational dual, reveal the (electro)elastic character of (charged) black branes when considering extrinsic perturbations.

  1. Elastic K-means using posterior probability.

    Science.gov (United States)

    Zheng, Aihua; Jiang, Bo; Li, Yan; Zhang, Xuehan; Ding, Chris

    2017-01-01

    The widely used K-means clustering is a hard clustering algorithm. Here we propose a Elastic K-means clustering model (EKM) using posterior probability with soft capability where each data point can belong to multiple clusters fractionally and show the benefit of proposed Elastic K-means. Furthermore, in many applications, besides vector attributes information, pairwise relations (graph information) are also available. Thus we integrate EKM with Normalized Cut graph clustering into a single clustering formulation. Finally, we provide several useful matrix inequalities which are useful for matrix formulations of learning models. Based on these results, we prove the correctness and the convergence of EKM algorithms. Experimental results on six benchmark datasets demonstrate the effectiveness of proposed EKM and its integrated model.

  2. Data-Driven Problems in Elasticity

    Science.gov (United States)

    Conti, S.; Müller, S.; Ortiz, M.

    2018-01-01

    We consider a new class of problems in elasticity, referred to as Data-Driven problems, defined on the space of strain-stress field pairs, or phase space. The problem consists of minimizing the distance between a given material data set and the subspace of compatible strain fields and stress fields in equilibrium. We find that the classical solutions are recovered in the case of linear elasticity. We identify conditions for convergence of Data-Driven solutions corresponding to sequences of approximating material data sets. Specialization to constant material data set sequences in turn establishes an appropriate notion of relaxation. We find that relaxation within this Data-Driven framework is fundamentally different from the classical relaxation of energy functions. For instance, we show that in the Data-Driven framework the relaxation of a bistable material leads to material data sets that are not graphs.

  3. Application of elasticity theory at Sandia Labortories

    International Nuclear Information System (INIS)

    Davison, L.

    1975-01-01

    Examples are given of the application of linear elasticity theory to the solution of practical problems encountered at Sandia Laboratories. It is being applied to a very broad range of problems: those in one, two, and three spatial dimensions, some involving static and some dynamic response, to materials having isotropic and anisotropic symmetry, to homogeneous and inhomogeneous bodies, etc. Various extensions of the theory to include electric, magnetic and thermal effects, to account for material microstructure, for radiation and spall damage, chemical reactions, and other phenomena have been developed and/or applied. In some applications linear elasticity represents the physics of a problem well and is the theory of choice. In others the theory was used because it lent insight into a larger problem that was also attacked by means of other theories and/or experiment, and in some cases it serves as a part of a more encompassing theory

  4. Diffraction by an immersed elastic wedge

    CERN Document Server

    Croisille, Jean-Pierre

    1999-01-01

    This monograph presents the mathematical description and numerical computation of the high-frequency diffracted wave by an immersed elastic wave with normal incidence. The mathematical analysis is based on the explicit description of the principal symbol of the pseudo-differential operator connected with the coupled linear problem elasticity/fluid by the wedge interface. This description is subsequently used to derive an accurate numerical computation of diffraction diagrams for different incoming waves in the fluid, and for different wedge angles. The method can be applied to any problem of coupled waves by a wedge interface. This work is of interest for any researcher concerned with high frequency wave scattering, especially mathematicians, acousticians, engineers.

  5. Elastic Multibody Dynamics A Direct Ritz Approach

    CERN Document Server

    Bremer, H

    2008-01-01

    This textbook is an introduction to and exploration of a number of core topics in the field of applied mechanics: On the basis of Lagrange's Principle, a Central Equation of Dynamics is presented which yields a unified view on existing methods. From these, the Projection Equation is selected for the derivation of the motion equations of holonomic and of non-holonomic systems. The method is applied to rigid multibody systems where the rigid body is defined such that, by relaxation of the rigidity constraints, one can directly proceed to elastic bodies. A decomposition into subsystems leads to a minimal representation and to a recursive representation, respectively, of the equations of motion. Applied to elastic multibody systems one obtains, along with the use of spatial operators, a straight-on procedure for the interconnected partial and ordinary differential equations and the corresponding boundary conditions. The spatial operators are eventually applied to a RITZ series for approximation. The resulting equ...

  6. Elastic wave scattering methods: assessments and suggestions

    International Nuclear Information System (INIS)

    Gubernatis, J.E.

    1985-01-01

    The author was asked by the meeting organizers to review and assess the developments over the past ten or so years in elastic wave scattering methods and to suggest areas of future research opportunities. He highlights the developments, focusing on what he feels were distinct steps forward in our theoretical understanding of how elastic waves interact with flaws. For references and illustrative figures, he decided to use as his principal source the proceedings of the various annual Reviews of Progress in Quantitative Nondestructive Evaluation (NDE). These meetings have been the main forum not only for presenting results of theoretical research but also for demonstrating the relevance of the theoretical research for the design and interpretation of experiment. In his opinion a quantitative NDE is possible only if this relevance exists, and his major objective is to discuss and illustrate the degree to which relevance has developed

  7. The multiple V-shaped double peeling of elastic thin films from elastic soft substrates

    Science.gov (United States)

    Menga, N.; Afferrante, L.; Pugno, N. M.; Carbone, G.

    2018-04-01

    In this paper, a periodic configuration of V-shaped double peeling process is investigated. Specifically, an elastic thin film is detached from a soft elastic material by applying multiple concentrated loads periodically distributed with spatial periodicity λ. The original Kendall's idea is extended to take into account the change in elastic energy occurring in the substrate when the detachment fronts propagate. The symmetric configuration typical of a V-peeling process causes the energy release rate to be sensitive to variations of the elastic energy stored in the soft substrate. This results in an enhancement of the adhesion strength because part of the external work required to trigger the peeling mechanism is converted in substrate elastic energy. A key role is played by both spatial periodicity λ and elasticity ratio E/Eh, between tape and substrate elastic moduli, in determining the conditions of stable adhesion. Indeed, the presence of multiple peeling fronts determines a modification of the mechanism of interaction, because deformations close to each peeling front are also affected by the stresses related to the other fronts. Results show that the energy release rate depends on the detached length of the tape so that conditions can be established which lead to an increase of the supported load compared to the classical peeling on rigid substrates. Finally, we also find that for any given value of the load per unit length, an optimum value of the wavelength λ exists that maximizes the tolerance of the system, before unstable propagation of the peeling front can occur.

  8. Dynamic elastic moduli of rocks under pressure

    Energy Technology Data Exchange (ETDEWEB)

    Schock, R N [Lawrence Radiation Laboratory, University of California, Livermore, CA (United States)

    1970-05-01

    Elastic moduli are determined as a function of confining pressure to 10 kb on rocks in which Plowshare shots are to be fired. Numerical simulation codes require accurate information on the mechanical response of the rock medium to various stress levels in order to predict cavity dimensions. The theoretical treatment of small strains in an elastic medium relates the propagation velocity of compressional and shear waves to the elastic moduli. Velocity measurements can provide, as unique code input data, the rigidity modulus, Poisson' ratio and the shear wave velocity, as well as providing checks on independent determinations of the other moduli. Velocities are determined using pulsed electro-mechanical transducers and measuring the time-of-flight in the rock specimen. A resonant frequency of 1 MHz is used to insure that the wavelength exceeds the average grain dimension and is subject to bulk rock properties. Data obtained on a variety of rock types are presented and analyzed. These data are discussed in terms of their relationship to moduli measured by static methods as well as the effect of anisotropy, porosity, and fractures. In general, fractured rocks with incipient cracks show large increases in velocity and moduli in the first 1 to 2 kb of compression as a result of the closing of these voids. After this, the velocities increase much more slowly. Dynamic moduli for these rocks are often 10% higher than corresponding static moduli at low pressure, but this difference decreases as the voids are closed until the moduli agree within experimental error. The discrepancy at low pressure is a result of the elastic energy in the wave pulse being propagated around cracks, with little effect on propagation velocity averaged over the entire specimen. (author)

  9. On the elastic stiffness of grain boundaries

    International Nuclear Information System (INIS)

    Zhang Tongyi; Hack, J.E.

    1992-01-01

    The elastic softening of grain boundaries is evaluated from the starting point of grain boundary energy. Several examples are given to illustrate the relationship between boundary energy and the extent of softening. In general, a high grain boundary energy is associated with a large excess atomic volume in the boundary region. The consequent reduction in grain boundary stiffness can represent a significant fraction of that observed in bulk crystals. (orig.)

  10. Thermal elastic deformations of the planet Mercury.

    Science.gov (United States)

    Liu, H.-S.

    1972-01-01

    The variation in solar heating due to the resonance rotation of Mercury produces periodic elastic deformations on the surface of the planet. The thermal stress and strain fields under Mercury's surface are calculated after certain simplifications. It is found that deformations penetrate to a greater depth than the variation of solar heating, and that the thermal strain on the surface of the planet pulsates with an amplitude of .004 and a period of 176 days.

  11. pp elastic scattering at LHC energies

    Energy Technology Data Exchange (ETDEWEB)

    Kohara, A.K.; Ferreira, E.; Kodama, T. [Universidade Federal do Rio de Janeiro, Instituto de Fisica, C.P. 68528, Rio de Janeiro, RJ (Brazil)

    2014-11-15

    Using a unified analytic representation for the elastic scattering amplitudes of pp scattering valid for all energies above 20 GeV, the behavior of observables in the LHC collisions in the range √(s) = 2.76-14 TeV is discussed. After the precise description of dσ/dt at 7 TeV, we discuss the energy dependence of the amplitudes and expect that the proposed analytical forms give equally good predictions for the future experiments. (orig.)

  12. pp elastic scattering at LHC energies

    International Nuclear Information System (INIS)

    Kohara, A.K.; Ferreira, E.; Kodama, T.

    2014-01-01

    Using a unified analytic representation for the elastic scattering amplitudes of pp scattering valid for all energies above 20 GeV, the behavior of observables in the LHC collisions in the range √(s) = 2.76-14 TeV is discussed. After the precise description of dσ/dt at 7 TeV, we discuss the energy dependence of the amplitudes and expect that the proposed analytical forms give equally good predictions for the future experiments. (orig.)

  13. Elastic stresses in u-shaped bellows

    International Nuclear Information System (INIS)

    Janzen, P.

    1980-05-01

    This report presents relations describing the meridional and circumferential elastic stress levels at the root and crown due to external pressure and axial deflection of U-shaped bellows. The derivation is based on a statistical analysis of theoretical data obtained from a finite element analysis of selected bellows configurations. The mathematical formulations and various graphical representations are proposed as aids to bellows design and analysis. (auth)

  14. Hydrogen depth profiling using elastic recoil detection

    International Nuclear Information System (INIS)

    Doyle, B.L.; Peercy, P.S.

    1979-01-01

    The elastic recoil detection (ERD) analysis technique for H profiling in the near surface regions of solids is described. ERD is shown to have the capability of detecting H and its isotopes down to concentrations of approx. 0.01 at. % with a depth resolution of a few hundred angstroms. Is is demonstrated that 2.4-MeV He ions can be used successfully to profile 1 H and 2 D using this technique. 12 figures

  15. Recent advances in elasticity, viscoelasticity and inelasticity

    CERN Document Server

    Rajagopal, KR

    1995-01-01

    This is a collection of papers dedicated to Prof T C Woo to mark his 70th birthday. The papers focus on recent advances in elasticity, viscoelasticity and inelasticity, which are related to Prof Woo's work. Prof Woo's recent work concentrates on the viscoelastic and viscoplastic response of metals and plastics when thermal effects are significant, and the papers here address open questions in these and related areas.

  16. Asymptotic elastic energy in simple metals

    International Nuclear Information System (INIS)

    Khalifeh, J.M.

    1983-07-01

    The asymptotic form of the elastic binding energy ΔEsup(as)(R) between two Mg atoms in Al is expressed as a product of a lattice Green function and the dipole force tensor P. The quantity P is obtained by a nearly free electron model in which the impurity effect is introduced by a screened Ashcroft pseudopotential characterized by an excess charge ΔZ and a core radius rsub(j). (author)

  17. Area distribution of an elastic Brownian motion

    International Nuclear Information System (INIS)

    Rajabpour, M A

    2009-01-01

    We calculate the excursion and meander area distributions of the elastic Brownian motion by using the self-adjoint extension of the Hamiltonian of the free quantum particle on the half line. We also give some comments on the area of the Brownian motion bridge on the real line with the origin removed. We will focus on the power of self-adjoint extension to investigate different possible boundary conditions for the stochastic processes. We also discuss some possible physical applications.

  18. Dynamic elastic moduli of rocks under pressure

    International Nuclear Information System (INIS)

    Schock, R.N.

    1970-01-01

    Elastic moduli are determined as a function of confining pressure to 10 kb on rocks in which Plowshare shots are to be fired. Numerical simulation codes require accurate information on the mechanical response of the rock medium to various stress levels in order to predict cavity dimensions. The theoretical treatment of small strains in an elastic medium relates the propagation velocity of compressional and shear waves to the elastic moduli. Velocity measurements can provide, as unique code input data, the rigidity modulus, Poisson' ratio and the shear wave velocity, as well as providing checks on independent determinations of the other moduli. Velocities are determined using pulsed electro-mechanical transducers and measuring the time-of-flight in the rock specimen. A resonant frequency of 1 MHz is used to insure that the wavelength exceeds the average grain dimension and is subject to bulk rock properties. Data obtained on a variety of rock types are presented and analyzed. These data are discussed in terms of their relationship to moduli measured by static methods as well as the effect of anisotropy, porosity, and fractures. In general, fractured rocks with incipient cracks show large increases in velocity and moduli in the first 1 to 2 kb of compression as a result of the closing of these voids. After this, the velocities increase much more slowly. Dynamic moduli for these rocks are often 10% higher than corresponding static moduli at low pressure, but this difference decreases as the voids are closed until the moduli agree within experimental error. The discrepancy at low pressure is a result of the elastic energy in the wave pulse being propagated around cracks, with little effect on propagation velocity averaged over the entire specimen. (author)

  19. Elastic wave diffraction by infinite wedges

    Energy Technology Data Exchange (ETDEWEB)

    Fradkin, Larissa; Zernov, Victor [Sound Mathematics Ltd., Cambridge CB4 2AS (United Kingdom); Gautesen, Arthur [Mathematics Department, Iowa State University and Ames Laboratory (United States); Darmon, Michel, E-mail: l.fradkin@soundmathematics.com [CEA-LIST, CEA-Saclay, 91191 Gif-sur-Yvette (France)

    2011-01-01

    We compare two recently developed semi-analytical approaches to the classical problem of diffraction by an elastic two dimensional wedge, one based on the reciprocity principle and Fourier Transform and another, on the representations of the elastodynamic potentials in the form of Sommerfeld Integrals. At present, in their common region of validity, the approaches are complementary, one working better than the other at some isolated angles of incidence.

  20. Graphene nanoribbon as an elastic damper

    Science.gov (United States)

    Evazzade, Iman; Lobzenko, Ivan P.; Saadatmand, Danial; Korznikova, Elena A.; Zhou, Kun; Liu, Bo; Dmitriev, Sergey V.

    2018-05-01

    Heterostructures composed of dissimilar two-dimensional nanomaterials can have nontrivial physical and mechanical properties which are potentially useful in many applications. Interestingly, in some cases, it is possible to create heterostructures composed of weakly and strongly stretched domains with the same chemical composition, as has been demonstrated for some polymer chains, DNA, and intermetallic nanowires supporting this effect of two-phase stretching. These materials, at relatively strong tension forces, split into domains with smaller and larger tensile strains. Within this region, average strain increases at constant tensile force due to the growth of the domain with the larger strain, at the expense of the domain with smaller strain. Here, the two-phase stretching phenomenon is described for graphene nanoribbons with the help of molecular dynamics simulations. This unprecedented feature of graphene that is revealed in our study is related to the peculiarities of nucleation and the motion of the domain walls separating the domains of different elastic strain. It turns out that the loading–unloading curves exhibit a hysteresis-like behavior due to the energy dissipation during the domain wall nucleation and motion. Here, we put forward the idea of implementing graphene nanoribbons as elastic dampers, efficiently converting mechanical strain energy into heat during cyclic loading–unloading through elastic extension where domains with larger and smaller strains coexist. Furthermore, in the regime of two-phase stretching, graphene nanoribbon is a heterostructure for which the fraction of domains with larger and smaller strain, and consequently its physical and mechanical properties, can be tuned in a controllable manner by applying elastic strain and/or heat.

  1. Price Elasticities of Food Demand: Compensated vs Uncompensated.

    Science.gov (United States)

    Clements, Kenneth W; Si, Jiawei

    2016-11-01

    Two recent studies have provided a comprehensive review/summary of a large number of estimates of the price elasticity of food consumption using a meta-regression approach. In this letter, we introduce a way of removing the income effect from these elasticities to recover the compensated elasticities. Although the income effect is small, the compensated elasticities vary by income group. Both types of elasticity should possibly be considered when assessing the impact of policy changes on food consumption. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd.

  2. Towards an elastic model of wurtzite AlN nanowires

    International Nuclear Information System (INIS)

    Mitrushchenkov, A; Chambaud, G; Yvonnet, J; He, Q-C

    2010-01-01

    Starting with ab initio calculations of AlN wurtzite [0001] nanowires with diameters up to 4 nm, a finite element method is developed to deal with larger nanostructures/nanoparticles. The ab initio calculations show that the structure of the nanowires can be well represented by an internal part with AlN bulk elastic properties, and one atomic surface layer with its own elastic behavior. The proposed finite element method includes surface elements with their own elastic properties using surface elastic coefficients deduced from the ab initio calculations. The elastic properties obtained with the finite element model compare very well with those obtained with the full ab initio calculations.

  3. Identification of elastic properties of composite plate

    International Nuclear Information System (INIS)

    Kovalovs, A; Rucevskis, S

    2011-01-01

    Composite laminates are used extensively in the aerospace industry, especially for the fabrication of high-performance structures. The determination of stiffness parameters for complex materials, such as fibre-reinforced composites, is much more complicated than for isotropic materials. A conventional way is testing the coupon specimens, which are manufactured by technology similar to that used for the real, large structures. When such a method is used, the question arises of whether the material properties obtained from the coupon tests are the same as those in the large structure. Therefore, the determination of actual material properties for composite laminates using non-destructive evaluation techniques has been widely investigated. A number of various non-destructive evaluation techniques have been proposed for determining the material properties of composite laminates. In the present study, attention is focused on the identification of the elastic properties of laminated plate using vibration test data. The problem associated with vibration testing is converting the measured modal frequencies to elastic constants. A standard method for solving this problem is the use of a numerical-experimental model and optimization techniques. The identification functional represents the gap between the numerical model response and the experimental one. This gap should be minimized, taking into account the side constraints on the design variables (elastic constants). The minimization problem is solved by using non-linear mathematical programming techniques and sensitivity analysis. The results obtained were verified by comparing the experimentally measured eigenfrequencies with the numerical ones obtained by FEM at the point of optima

  4. Elastic Properties and Stability of Physisorbed Graphene

    Directory of Open Access Journals (Sweden)

    Philippe Lambin

    2014-05-01

    Full Text Available Graphene is an ultimate membrane that mixes both flexibility and mechanical strength, together with many other remarkable properties. A good knowledge of the elastic properties of graphene is prerequisite to any practical application of it in nanoscopic devices. Although this two-dimensional material is only one atom thick, continuous-medium elasticity can be applied as long as the deformations vary slowly on the atomic scale and provided suitable parameters are used. The present paper aims to be a critical review on this topic that does not assume a specific pre-knowledge of graphene physics. The basis for the paper is the classical Kirchhoff-Love plate theory. It demands a few parameters that can be addressed from many points of view and fitted to independent experimental data. The parameters can also be estimated by electronic structure calculations. Although coming from diverse backgrounds, most of the available data provide a rather coherent picture that gives a good degree of confidence in the classical description of graphene elasticity. The theory can than be used to estimate, e.g., the buckling limit of graphene bound to a substrate. It can also predict the size above which a scrolled graphene sheet will never spontaneously unroll in free space.

  5. Environmental bias and elastic curves on surfaces

    International Nuclear Information System (INIS)

    Guven, Jemal; María Valencia, Dulce; Vázquez-Montejo, Pablo

    2014-01-01

    The behavior of an elastic curve bound to a surface will reflect the geometry of its environment. This may occur in an obvious way: the curve may deform freely along directions tangent to the surface, but not along the surface normal. However, even if the energy itself is symmetric in the curve's geodesic and normal curvatures, which control these modes, very distinct roles are played by the two. If the elastic curve binds preferentially on one side, or is itself assembled on the surface, not only would one expect the bending moduli associated with the two modes to differ, binding along specific directions, reflected in spontaneous values of these curvatures, may be favored. The shape equations describing the equilibrium states of a surface curve described by an elastic energy accommodating environmental factors will be identified by adapting the method of Lagrange multipliers to the Darboux frame associated with the curve. The forces transmitted to the surface along the surface normal will be determined. Features associated with a number of different energies, both of physical relevance and of mathematical interest, are described. The conservation laws associated with trajectories on surface geometries exhibiting continuous symmetries are also examined. (paper)

  6. Impact loads on beams on elastic foundations

    International Nuclear Information System (INIS)

    Kameswara Rao, N.S.V.; Prasad, B.B.

    1975-01-01

    Quite often, complex structural components are idealised as beams in engineering analysis and design. Also, equations governing the responses of shallow shells are mathematically equivalent to the equations governing the responses of beams on elastic foundations. Hence with possible applications in several technical disciplines, the behaviour of beams on elastic foundations subjected to impact loads is studied in detail in the present investigation both analytically and experimentally. The analytical methods include analysis and energy method. The effect of foundation parameters (stiffness, and damping constants) on the dynamic responses of the beam-foundation system has been analysed. In modal analysis, the free-vibration equation has been solved by replacing the applied impulse by suitable initial conditions and the solution has been obtained as the linear combination of an infinite sequence of discrete eigen-vectors. In the energy method, the beam-foundation system is treated to be under forced vibrations and the forcing function has been obtained using the Hertz's law of impact. In the case of free-free end conditions of the beam, the rigid body modes and the elastic modes have been superposed to obtain the total response. The responses predicted using modal analysis are higher than those obtained using energy method. From the present study it is observed that model analysis is preferable to energy method. (Auth.)

  7. Fringe instability in constrained soft elastic layers.

    Science.gov (United States)

    Lin, Shaoting; Cohen, Tal; Zhang, Teng; Yuk, Hyunwoo; Abeyaratne, Rohan; Zhao, Xuanhe

    2016-11-04

    Soft elastic layers with top and bottom surfaces adhered to rigid bodies are abundant in biological organisms and engineering applications. As the rigid bodies are pulled apart, the stressed layer can exhibit various modes of mechanical instabilities. In cases where the layer's thickness is much smaller than its length and width, the dominant modes that have been studied are the cavitation, interfacial and fingering instabilities. Here we report a new mode of instability which emerges if the thickness of the constrained elastic layer is comparable to or smaller than its width. In this case, the middle portion along the layer's thickness elongates nearly uniformly while the constrained fringe portions of the layer deform nonuniformly. When the applied stretch reaches a critical value, the exposed free surfaces of the fringe portions begin to undulate periodically without debonding from the rigid bodies, giving the fringe instability. We use experiments, theory and numerical simulations to quantitatively explain the fringe instability and derive scaling laws for its critical stress, critical strain and wavelength. We show that in a force controlled setting the elastic fingering instability is associated with a snap-through buckling that does not exist for the fringe instability. The discovery of the fringe instability will not only advance the understanding of mechanical instabilities in soft materials but also have implications for biological and engineered adhesives and joints.

  8. A symplectic integration method for elastic filaments

    Science.gov (United States)

    Ladd, Tony; Misra, Gaurav

    2009-03-01

    Elastic rods are a ubiquitous coarse-grained model of semi-flexible biopolymers such as DNA, actin, and microtubules. The Worm-Like Chain (WLC) is the standard numerical model for semi-flexible polymers, but it is only a linearized approximation to the dynamics of an elastic rod, valid for small deflections; typically the torsional motion is neglected as well. In the standard finite-difference and finite-element formulations of an elastic rod, the continuum equations of motion are discretized in space and time, but it is then difficult to ensure that the Hamiltonian structure of the exact equations is preserved. Here we discretize the Hamiltonian itself, expressed as a line integral over the contour of the filament. This discrete representation of the continuum filament can then be integrated by one of the explicit symplectic integrators frequently used in molecular dynamics. The model systematically approximates the continuum partial differential equations, but has the same level of computational complexity as molecular dynamics and is constraint free. Numerical tests show that the algorithm is much more stable than a finite-difference formulation and can be used for high aspect ratio filaments, such as actin. We present numerical results for the deterministic and stochastic motion of single filaments.

  9. Elastic constants from microscopic strain fluctuations

    Science.gov (United States)

    Sengupta; Nielaba; Rao; Binder

    2000-02-01

    Fluctuations of the instantaneous local Lagrangian strain epsilon(ij)(r,t), measured with respect to a static "reference" lattice, are used to obtain accurate estimates of the elastic constants of model solids from atomistic computer simulations. The measured strains are systematically coarse-grained by averaging them within subsystems (of size L(b)) of a system (of total size L) in the canonical ensemble. Using a simple finite size scaling theory we predict the behavior of the fluctuations as a function of L(b)/L and extract elastic constants of the system in the thermodynamic limit at nonzero temperature. Our method is simple to implement, efficient, and general enough to be able to handle a wide class of model systems, including those with singular potentials without any essential modification. We illustrate the technique by computing isothermal elastic constants of "hard" and "soft" disk triangular solids in two dimensions from Monte Carlo and molecular dynamics simulations. We compare our results with those from earlier simulations and theory.

  10. Wave anisotropy of shear viscosity and elasticity

    Science.gov (United States)

    Rudenko, O. V.; Sarvazyan, A. P.

    2014-11-01

    The paper presents the theory of shear wave propagation in a "soft solid" material possessing anisotropy of elastic and dissipative properties. The theory is developed mainly for understanding the nature of the low-frequency acoustic characteristics of skeletal muscles, which carry important diagnostic information on the functional state of muscles and their pathologies. It is shown that the shear elasticity of muscles is determined by two independent moduli. The dissipative properties are determined by the fourth-rank viscosity tensor, which also has two independent components. The propagation velocity and attenuation of shear waves in muscle depend on the relative orientation of three vectors: the wave vector, the polarization vector, and the direction of muscle fiber. For one of the many experiments where attention was distinctly focused on the vector character of the wave process, it was possible to make a comparison with the theory, estimate the elasticity moduli, and obtain agreement with the angular dependence of the wave propagation velocity predicted by the theory.

  11. The elasticity of demand for gasoline in China

    International Nuclear Information System (INIS)

    Lin, C.-Y. Cynthia; Zeng, Jieyin

    2013-01-01

    This paper estimates the price and income elasticities of demand for gasoline in China. Our estimates of the intermediate-run price elasticity of gasoline demand range between −0.497 and −0.196, and our estimates of the intermediate-run income elasticity of gasoline demand range between 1.01 and 1.05. We also extend previous studies to estimate the vehicle miles traveled (VMT) elasticity and obtain a range from −0.882 to −0.579. - highlights: • The price elasticity of demand for gasoline in China is between −0.497 and −0.196. • The income elasticity of demand for gasoline in China is between 1.01 and 1.05. • The price elasticity of demand for VMT in China is between −0.882 and −0.579

  12. Observation of elastic topological states in soft materials.

    Science.gov (United States)

    Li, Shuaifeng; Zhao, Degang; Niu, Hao; Zhu, Xuefeng; Zang, Jianfeng

    2018-04-10

    Topological elastic metamaterials offer insight into classic motion law and open up opportunities in quantum and classic information processing. Theoretical modeling and numerical simulation of elastic topological states have been reported, whereas the experimental observation remains relatively unexplored. Here we present an experimental observation and numerical simulation of tunable topological states in soft elastic metamaterials. The on-demand reversible switch in topological phase has been achieved by changing filling ratio, tension, and/or compression of the elastic metamaterials. By combining two elastic metamaterials with distinct topological invariants, we further demonstrate the formation and dynamic tunability of topological interface states by mechanical deformation, and the manipulation of elastic wave propagation. Moreover, we provide a topological phase diagram of elastic metamaterials under deformation. Our approach to dynamically control interface states in soft materials paves the way to various phononic systems involving thermal management and soft robotics requiring better use of energy.

  13. In Silico Measurement of Elastic Moduli of Nematic Liquid Crystals

    Science.gov (United States)

    Sidky, Hythem; de Pablo, Juan J.; Whitmer, Jonathan K.

    2018-03-01

    Experiments on confined droplets of the nematic liquid crystal 5CB have questioned long-established bounds imposed on the elastic free energy of nematic systems. This elasticity, which derives from molecular alignment within nematic systems, is quantified through a set of moduli which can be difficult to measure experimentally and, in some cases, can only be probed indirectly. This is particularly true of the surfacelike saddle-splay elastic term, for which the available experimental data indicate values on the cusp of stability, often with large uncertainties. Here, we demonstrate that all nematic elastic moduli, including the saddle-splay elastic constant k24, may be calculated directly from atomistic molecular simulations. Importantly, results obtained through in silico measurements of the 5CB elastic properties demonstrate unambiguously that saddle-splay elasticity alone is unable to describe the observed confined morphologies.

  14. Growth-induced axial buckling of a slender elastic filament embedded in an isotropic elastic matrix

    KAUST Repository

    O'Keeffe, Stephen G.

    2013-11-01

    We investigate the problem of an axially loaded, isotropic, slender cylinder embedded in a soft, isotropic, outer elastic matrix. The cylinder undergoes uniform axial growth, whilst both the cylinder and the surrounding elastic matrix are confined between two rigid plates, so that this growth results in axial compression of the cylinder. We use two different modelling approaches to estimate the critical axial growth (that is, the amount of axial growth the cylinder is able to sustain before it buckles) and buckling wavelength of the cylinder. The first approach treats the filament and surrounding matrix as a single 3-dimensional elastic body undergoing large deformations, whilst the second approach treats the filament as a planar, elastic rod embedded in an infinite elastic foundation. By comparing the results of these two approaches, we obtain an estimate of the foundation modulus parameter, which characterises the strength of the foundation, in terms of the geometric and material properties of the system. © 2013 Elsevier Ltd. All rights reserved.

  15. Elasticity of fluorite at high temperatures

    Science.gov (United States)

    Eke, J.; Tennakoon, S.; Mookherjee, M.

    2017-12-01

    Fluorite (CaF2) is a simple halide with cubic space group symmetry (Fm-3m) and is often used as an internal pressure calibrant in moderate high-pressure/high-temperature experiments [1]. In order to gain insight into the elastic behavior of fluorite, we have conducted Resonant Ultrasound Spectroscopy (RUS) on a single crystal of fluorite with rectangular parallelepiped geometry. Using single crystal X-ray diffraction, we aligned the edges of the rectangular parallelepiped with [-1 1 1], [-1 1 -2], and [-1 -1 0] crystallographic directions. We conducted the RUS measurements up to 620 K. RUS spectra are influenced by the geometry, density, and the full elastic moduli tensor of the material. In our high-temperature RUS experiments, the geometry and density were constrained using thermal expansion from previous studies [2]. We determined the elasticity by minimizing the difference between observed resonance and calculated Eigen frequency using Rayleigh-Ritz method [3]. We found that at room temperature, the single crystal elastic moduli for fluorite are 170, 49, and 33 GPa for C11, C12, and C44 respectively. At room temperatures, the aggregate bulk modulus (K) is 90 GPa and the shear modulus (G) is 43 GPa. We note that the elastic moduli and sound wave velocities decrease linearly as a function of temperature with dVP /dT and dVS /dT being -9.6 ×10-4 and -5.0 ×10-4 km/s/K respectively. Our high-temperature RUS results are in good agreement with previous studies on fluorite using both Ultrasonic methods and Brillouin scattering [4,5]. Acknowledgement: This study is supported by US NSF awards EAR-1639552 and EAR-1634422. References: [1] Speziale, S., Duffy, T. S. 2002, Phys. Chem. Miner., 29, 465-472; [2] Roberts, R. B., White, G. K., 1986, J. Phys. C: Solid State Phys., 19, 7167-7172. [3] Migliori, A., Maynard, J. D., 2005, Rev. Sci. Instrum., 76, 121301. [4] Catlow, C. R. A., Comins, J. D., Germano, F. A., Harley, R. T., Hayes, W., 1978, J. Phys. C Solid State Phys

  16. Characterization of the mechanical properties of resected porcine organ tissue using optical fiber photoelastic polarimetry.

    Science.gov (United States)

    Hudnut, Alexa W; Babaei, Behzad; Liu, Sonya; Larson, Brent K; Mumenthaler, Shannon M; Armani, Andrea M

    2017-10-01

    Characterizing the mechanical behavior of living tissue presents an interesting challenge because the elasticity varies by eight orders of magnitude, from 50Pa to 5GPa. In the present work, a non-destructive optical fiber photoelastic polarimetry system is used to analyze the mechanical properties of resected samples from porcine liver, kidney, and pancreas. Using a quasi-linear viscoelastic fit, the elastic modulus values of the different organ systems are determined. They are in agreement with previous work. In addition, a histological assessment of compressed and uncompressed tissues confirms that the tissue is not damaged during testing.

  17. Relationship between the Uncompensated Price Elasticity and the Income Elasticity of Demand under Conditions of Additive Preferences.

    Science.gov (United States)

    Sabatelli, Lorenzo

    2016-01-01

    Income and price elasticity of demand quantify the responsiveness of markets to changes in income and in prices, respectively. Under the assumptions of utility maximization and preference independence (additive preferences), mathematical relationships between income elasticity values and the uncompensated own and cross price elasticity of demand are here derived using the differential approach to demand analysis. Key parameters are: the elasticity of the marginal utility of income, and the average budget share. The proposed method can be used to forecast the direct and indirect impact of price changes and of financial instruments of policy using available estimates of the income elasticity of demand.

  18. Relationship between the Uncompensated Price Elasticity and the Income Elasticity of Demand under Conditions of Additive Preferences.

    Directory of Open Access Journals (Sweden)

    Lorenzo Sabatelli

    Full Text Available Income and price elasticity of demand quantify the responsiveness of markets to changes in income and in prices, respectively. Under the assumptions of utility maximization and preference independence (additive preferences, mathematical relationships between income elasticity values and the uncompensated own and cross price elasticity of demand are here derived using the differential approach to demand analysis. Key parameters are: the elasticity of the marginal utility of income, and the average budget share. The proposed method can be used to forecast the direct and indirect impact of price changes and of financial instruments of policy using available estimates of the income elasticity of demand.

  19. Transient Vibrations of an Elastic Cylinder Inserted in the Elastic Medium

    Directory of Open Access Journals (Sweden)

    Sulym Heorgij

    2016-06-01

    Full Text Available Using method of Laguerre polynomials we have obtained the solution of the dynamic problem of the theory of elasticity for elastic cylinder inserted into massive body modeled as a space. The source of non-stationary processes in composite is high intensity force load of the inner surface of the cylinder. On the surface separation of materials of space and cylinder the conditions of ideal mechanical contact are satisfied. The solution is obtained as series of Laguerre polynomials, which coefficients are found from recurrent relations. The results of numerical analysis of transient stress-strain state in elastic space with cylindrical insertion might be used for the technological process of hydraulic fracturing during shale gas extraction.

  20. On elastic moduli and elastic anisotropy in polycrystalline martensitic NiTi

    International Nuclear Information System (INIS)

    Qiu, S.; Clausen, B.; Padula, S.A.; Noebe, R.D.; Vaidyanathan, R.

    2011-01-01

    A combined experimental and computational effort was undertaken to provide insight into the elastic response of B19' martensitic NiTi variants as they exist in bulk, polycrystalline aggregate form during monotonic tensile and compressive loading. The experimental effort centered on using in situ neutron diffraction during loading to measure elastic moduli in several directions along with an average Young's modulus and a Poisson's ratio. The measurements were compared with predictions from a 30,000 variant, self-consistent polycrystalline deformation model that accounted for the elastic intergranular constraint, and also with predictions of single crystal behavior from previously published ab initio studies. Variant conversion and detwinning processes that influenced the intergranular constraint occurred even at stresses where the macroscopic stress-strain response appeared linear. Direct evidence of these processes was revealed in changes in texture, which were captured in inverse pole figures constructed from the neutron diffraction measurements.

  1. On elastic moduli and elastic anisotropy in polycrystalline martensitic NiTi

    Energy Technology Data Exchange (ETDEWEB)

    Qiu, S. [Advanced Materials Processing and Analysis Center (AMPAC), Mechanical, Materials and Aerospace Engineering Department, University of Central Florida, Orlando, FL 32816 (United States); Clausen, B. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Padula, S.A.; Noebe, R.D. [NASA Glenn Research Center, Cleveland, OH 44135 (United States); Vaidyanathan, R., E-mail: raj@mail.ucf.edu [Advanced Materials Processing and Analysis Center (AMPAC), Mechanical, Materials and Aerospace Engineering Department, University of Central Florida, Orlando, FL 32816 (United States)

    2011-08-15

    A combined experimental and computational effort was undertaken to provide insight into the elastic response of B19' martensitic NiTi variants as they exist in bulk, polycrystalline aggregate form during monotonic tensile and compressive loading. The experimental effort centered on using in situ neutron diffraction during loading to measure elastic moduli in several directions along with an average Young's modulus and a Poisson's ratio. The measurements were compared with predictions from a 30,000 variant, self-consistent polycrystalline deformation model that accounted for the elastic intergranular constraint, and also with predictions of single crystal behavior from previously published ab initio studies. Variant conversion and detwinning processes that influenced the intergranular constraint occurred even at stresses where the macroscopic stress-strain response appeared linear. Direct evidence of these processes was revealed in changes in texture, which were captured in inverse pole figures constructed from the neutron diffraction measurements.

  2. Compressive elasticity of three-dimensional nanofiber matrix directs mesenchymal stem cell differentiation to vascular cells with endothelial or smooth muscle cell markers.

    Science.gov (United States)

    Wingate, K; Bonani, W; Tan, Y; Bryant, S J; Tan, W

    2012-04-01

    The importance of mesenchymal stem cells (MSC) in vascular regeneration is becoming increasingly recognized. However, few in vitro studies have been performed to identify the effects of environmental elasticity on the differentiation of MSC into vascular cell types. Electrospinning and photopolymerization techniques were used to fabricate a three-dimensional (3-D) polyethylene glycol dimethacrylate nanofiber hydrogel matrix with tunable elasticity for use as a cellular substrate. Compression testing demonstrated that the elastic modulus of the hydrated 3-D matrices ranged from 2 to 15 kPa, similar to the in vivo elasticity of the intima basement membrane and media layer. MSC seeded on rigid matrices (8-15 kPa) showed an increase in cell area compared with those seeded on soft matrices (2-5 kPa). Furthermore, the matrix elasticity guided the cells to express different vascular-specific phenotypes with high differentiation efficiency. Around 95% of MSC seeded on the 3-D matrices with an elasticity of 3 kPa showed Flk-1 endothelial markers within 24h, while only 20% of MSC seeded on the matrices with elasticity >8 kPa demonstrated Flk-1 marker. In contrast, ∼80% of MSC seeded on 3-D matrices with elasticity >8 kPa demonstrated smooth muscle α-actin marker within 24h, while fewer than 10% of MSC seeded on 3-D matrices with elasticity elasticity of the substrate could be a powerful tool for vascular tissue regeneration. Copyright © 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  3. High-energy elastic and quasi-elastic deuteron-nucleus scattering

    International Nuclear Information System (INIS)

    Tekou, Amouzou

    1974-01-01

    A study is made of deuteron-nucleus elastic and quasi-elastic scattering and the connection between the opaque nucleus model and the Glauber model is pointed out. The contributions to different cross-sections of the collisions in which the nucleus, excited by one of the nucleons of the deuteron, is brought back to the ground state by the other nucleon is analysed. Coherent deuteron disintegration is found to be highly improbable when the target nucleus is heavy and incoherent disintegration accounts for nearly all the deuteron disintegration. Thus a correct comparison between theoretical and experimental data on proton stripping must take the incoherent deuteron disintegration into consideration

  4. Uzawa algorithm to solve elastic and elastic-plastic fretting wear problems within the bipotential framework

    Science.gov (United States)

    Ning, Po; Feng, Zhi-Qiang; Quintero, Juan Antonio Rojas; Zhou, Yang-Jing; Peng, Lei

    2018-03-01

    This paper deals with elastic and elastic-plastic fretting problems. The wear gap is taken into account along with the initial contact distance to obtain the Signorini conditions. Both the Signorini conditions and the Coulomb friction laws are written in a compact form. Within the bipotential framework, an augmented Lagrangian method is applied to calculate the contact forces. The Archard wear law is then used to calculate the wear gap at the contact surface. The local fretting problems are solved via the Uzawa algorithm. Numerical examples are performed to show the efficiency and accuracy of the proposed approach. The influence of plasticity has been discussed.

  5. Energy in elastic fiber embedded in elastic matrix containing incident SH wave

    Science.gov (United States)

    Williams, James H., Jr.; Nagem, Raymond J.

    1989-01-01

    A single elastic fiber embedded in an infinite elastic matrix is considered. An incident plane SH wave is assumed in the infinite matrix, and an expression is derived for the total energy in the fiber due to the incident SH wave. A nondimensional form of the fiber energy is plotted as a function of the nondimensional wavenumber of the SH wave. It is shown that the fiber energy attains maximum values at specific values of the wavenumber of the incident wave. The results obtained here are interpreted in the context of phenomena observed in acousto-ultrasonic experiments on fiber reinforced composite materials.

  6. Multiscale approach including microfibril scale to assess elastic constants of cortical bone based on neural network computation and homogenization method.

    Science.gov (United States)

    Barkaoui, Abdelwahed; Chamekh, Abdessalem; Merzouki, Tarek; Hambli, Ridha; Mkaddem, Ali

    2014-03-01

    The complexity and heterogeneity of bone tissue require a multiscale modeling to understand its mechanical behavior and its remodeling mechanisms. In this paper, a novel multiscale hierarchical approach including microfibril scale based on hybrid neural network (NN) computation and homogenization equations was developed to link nanoscopic and macroscopic scales to estimate the elastic properties of human cortical bone. The multiscale model is divided into three main phases: (i) in step 0, the elastic constants of collagen-water and mineral-water composites are calculated by averaging the upper and lower Hill bounds; (ii) in step 1, the elastic properties of the collagen microfibril are computed using a trained NN simulation. Finite element calculation is performed at nanoscopic levels to provide a database to train an in-house NN program; and (iii) in steps 2-10 from fibril to continuum cortical bone tissue, homogenization equations are used to perform the computation at the higher scales. The NN outputs (elastic properties of the microfibril) are used as inputs for the homogenization computation to determine the properties of mineralized collagen fibril. The mechanical and geometrical properties of bone constituents (mineral, collagen, and cross-links) as well as the porosity were taken in consideration. This paper aims to predict analytically the effective elastic constants of cortical bone by modeling its elastic response at these different scales, ranging from the nanostructural to mesostructural levels. Our findings of the lowest scale's output were well integrated with the other higher levels and serve as inputs for the next higher scale modeling. Good agreement was obtained between our predicted results and literature data. Copyright © 2013 John Wiley & Sons, Ltd.

  7. Elastic energy within the human plantar aponeurosis contributes to arch shortening during the push-off phase of running.

    Science.gov (United States)

    Wager, Justin C; Challis, John H

    2016-03-21

    During locomotion, the lower limb tendons undergo stretch and recoil, functioning like springs that recycle energy with each step. Cadaveric testing has demonstrated that the arch of the foot operates in this capacity during simple loading, yet it remains unclear whether this function exists during locomotion. In this study, one of the arch׳s passive elastic tissues (the plantar aponeurosis; PA) was investigated to glean insights about it and the entire arch of the foot during running. Subject specific computer models of the foot were driven using the kinematics of eight subjects running at 3.1m/s using two initial contact patterns (rearfoot and non-rearfoot). These models were used to estimate PA strain, force, and elastic energy storage during the stance phase. To examine the release of stored energy, the foot joint moments, powers, and work created by the PA were computed. Mean elastic energy stored in the PA was 3.1±1.6J, which was comparable to in situ testing values. Changes to the initial contact pattern did not change elastic energy storage or late stance PA function, but did alter PA pre-tensioning and function during early stance. In both initial contact patterns conditions, the PA power was positive during late stance, which reveals that the release of the stored elastic energy assists with shortening of the arch during push-off. As the PA is just one of the arch׳s passive elastic tissues, the entire arch may store additional energy and impact the metabolic cost of running. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Ultrasound elasticity imaging of human posterior tibial tendon

    Science.gov (United States)

    Gao, Liang

    Posterior tibial tendon dysfunction (PTTD) is a common degenerative condition leading to a severe impairment of gait. There is currently no effective method to determine whether a patient with advanced PTTD would benefit from several months of bracing and physical therapy or ultimately require surgery. Tendon degeneration is closely associated with irreversible degradation of its collagen structure, leading to changes to its mechanical properties. If these properties could be monitored in vivo, it could be used to quantify the severity of tendonosis and help determine the appropriate treatment. Ultrasound elasticity imaging (UEI) is a real-time, noninvasive technique to objectively measure mechanical properties in soft tissue. It consists of acquiring a sequence of ultrasound frames and applying speckle tracking to estimate displacement and strain at each pixel. The goals of my dissertation were to 1) use acoustic simulations to investigate the performance of UEI during tendon deformation with different geometries; 2) develop and validate UEI as a potentially noninvasive technique for quantifying tendon mechanical properties in human cadaver experiments; 3) design a platform for UEI to measure mechanical properties of the PTT in vivo and determine whether there are detectable and quantifiable differences between healthy and diseased tendons. First, ultrasound simulations of tendon deformation were performed using an acoustic modeling program. The effects of different tendon geometries (cylinder and curved cylinder) on the performance of UEI were investigated. Modeling results indicated that UEI accurately estimated the strain in the cylinder geometry, but underestimated in the curved cylinder. The simulation also predicted that the out-of-the-plane motion of the PTT would cause a non-uniform strain pattern within incompressible homogeneous isotropic material. However, to average within a small region of interest determined by principal component analysis (PCA

  9. Mechanics of Fluctuating Elastic Plates and Fiber Networks

    Science.gov (United States)

    Liang, Xiaojun

    Lipid membranes and fiber networks in biological systems perform important mechanical functions at the cellular and tissue levels. In this thesis I delve into two detailed problems--thermal fluctuation of membranes and non-linear compression response of fiber networks. Typically, membrane fluctuations are analysed by decomposing into normal modes or by molecular simulations. In the first part of my thesis, I propose a new semi-analytic method to calculate the partition function of a membrane. The membrane is viewed as a fluctuating von Karman plate and discretized into triangular elements. Its energy is expressed as a function of nodal displacements, and then the partition function and co-variance matrix are computed using Gaussian integrals. I recover well-known results for the dependence of the projected area of a lipid bilayer membrane on the applied tension, and recent simulation results on the ependence of membrane free energy on geometry, spontaneous curvature and tension. As new applications I use this technique to study a membrane with heterogeneity and different boundary conditions. I also use this technique to study solid membranes by taking account of the non-linear coupling of in-plane strains with out-of-plane deflections using a penalty energy, and apply it to graphene, an ultra-thin two-dimensional solid. The scaling of graphene fluctuations with membrane size is recovered. I am able to capture the dependence of the thermal expansion coefficient of graphene on temperature. Next, I study curvature mediated interactions between inclusions in membranes. I assume the inclusions to be rigid, and show that the elastic and entropic forces between them can compete to yield a local maximum in the free energy if the membrane bending modulus is small. If the spacing between the inclusions is less than this local maximum then the attractive entropic forces dominate and the separation between the inclusions will be determined by short range interactions; if the

  10. Mathematical model of microbicidal flow dynamics and optimization of rheological properties for intra-vaginal drug delivery: Role of tissue mechanics and fluid rheology.

    Science.gov (United States)

    Anwar, Md Rajib; Camarda, Kyle V; Kieweg, Sarah L

    2015-06-25

    Topically applied microbicide gels can provide a self-administered and effective strategy to prevent sexually transmitted infections (STIs). We have investigated the interplay between vaginal tissue elasticity and the yield-stress of non-Newtonian fluids during microbicide deployment. We have developed a mathematical model of tissue deformation driven spreading of microbicidal gels based on thin film lubrication approximation and demonstrated the effect of tissue elasticity and fluid yield-stress on the spreading dynamics. Our results show that both elasticity of tissue and yield-stress rheology of gel are strong determinants of the coating behavior. An optimization framework has been demonstrated which leverages the flow dynamics of yield-stress fluid during deployment to maximize retention while reaching target coating length for a given tissue elasticity. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Measuring global gasoline and diesel price and income elasticities

    International Nuclear Information System (INIS)

    Dahl, Carol A.

    2012-01-01

    Price and income elasticities of transport fuel demand have numerous applications. They help forecast increases in fuel consumption as countries get richer, they help develop appropriate tax policies to curtail consumption, help determine how the transport fuel mix might evolve, and show the price response to a fuel disruption. Given their usefulness, it is understandable why hundreds of studies have focused on measuring such elasticities for gasoline and diesel fuel consumption. In this paper, I focus my attention on price and income elasticities in the existing studies to see what can be learned from them. I summarize the elasticities from these historical studies. I use statistical analysis to investigate whether income and price elasticities seem to be constant across countries with different incomes and prices. Although income and price elasticities for gasoline and diesel fuel are not found to be the same at high and low incomes and at high and low prices, patterns emerge that allow me to develop suggested price and income elasticities for gasoline and diesel demand for over one hundred countries. I adjust these elasticities for recent fuel mix policies, and suggest an agenda of future research topics. - Research highlights: ► Surveyed econometric studies of transport fuel demand. ► Developed price elasticities of demand for gasoline and diesel fuel for 120 countries. ► Developed income elasticities of demand for gasoline and diesel fuel for 120 countries. ► Suggested a research agenda for future work.

  12. Hypericin-mediated selective photomodification of connective tissues

    International Nuclear Information System (INIS)

    Hovhannisyan, V.; Guo, H. W.; Chen, Y. F.; Hovhannisyan, A.; Ghukasyan, V.; Dong, C. Y.

    2014-01-01

    Controllable modification of biological molecules and supramolecular components of connective tissue are important for biophysical and biomedical applications. Through the use of second harmonic generation imaging, two-photon fluorescence microscopy, and spectrofluorimetry, we found that hypericin, a natural pigment, induces photosensitized destruction of collagen fibers but does not affect elastic fibers and lipids in chicken tendon, skin, and blood vessels. We demonstrated the dynamics and efficiency of collagen photomodification and investigated mechanisms of this processes. Our results suggest that hypericin–mediated photoprocesses in biological tissues may be useful in biomedical applications that require selective modification of connective tissues

  13. Hypericin-mediated selective photomodification of connective tissues

    Energy Technology Data Exchange (ETDEWEB)

    Hovhannisyan, V., E-mail: hovv@phys.ntu.edu.tw; Guo, H. W.; Chen, Y. F., E-mail: yfchen@phys.ntu.edu.tw [Department of Physics, National Taiwan University, Taipei 106, Taiwan (China); Hovhannisyan, A. [Multimedia and Programming, European Regional Education Academy, Yerevan 0037 (Armenia); Ghukasyan, V. [Neuroscience Center, University of North Carolina at Chapel Hill, North Carolina 27514 (United States); Dong, C. Y., E-mail: cydong@phys.ntu.edu.tw [Department of Physics, National Taiwan University, Taipei 106, Taiwan (China); Center for Quantum Science and Engineering, National Taiwan University, Taipei 106, Taiwan (China)

    2014-12-29

    Controllable modification of biological molecules and supramolecular components of connective tissue are important for biophysical and biomedical applications. Through the use of second harmonic generation imaging, two-photon fluorescence microscopy, and spectrofluorimetry, we found that hypericin, a natural pigment, induces photosensitized destruction of collagen fibers but does not affect elastic fibers and lipids in chicken tendon, skin, and blood vessels. We demonstrated the dynamics and efficiency of collagen photomodification and investigated mechanisms of this processes. Our results suggest that hypericin–mediated photoprocesses in biological tissues may be useful in biomedical applications that require selective modification of connective tissues.

  14. Elasticity of stishovite at high pressure

    Science.gov (United States)

    Li, Baosheng; Rigden, Sally M.; Liebermann, Robert C.

    1996-08-01

    The elastic-wave velocities of stishovite, the rutile-structured polymorph of SiO 2, were measured to 3 GPa at room temperature in a piston cylinder apparatus using ultrasonic interferometry on polycrystalline samples. These polycrystalline samples (2-3 mm in length and diameter) were hot-pressed at 14 GPa and 1050°C in a 2000 ton uniaxial split-sphere apparatus (USSA-2000) using fused silica rods as starting material. They were characterized as low porosity (less than 1%), single phase, fine grained, free of cracks and preferred orientation, and acoustically isotropic by using density measurement, X-ray diffraction, scanning electron microscopy, and bench-top velocity measurements. On the basis of subsequent in situ X-ray diffraction study at high P and T on peak broadening on similar specimens, it is evident that the single crystal grains within these polycrystalline aggregates are well equilibrated and that these specimens are free of residual strain. P- and S-wave velocities measured at 1 atm are within 1.5% of the Hashin-Shtrikman bounds calculated from single-crystal elastic moduli. Measured pressure derivatives of the bulk and shear moduli, K' 0 = 5.3 ± 0.1 and G' 0 = 1.8 ± 0.1, are not unusual compared with values measured for other transition zone phases such as silicate spinel and majorite garnet. Isothermal compression curves calculated with the measured values of K0 and K' 0 agree well with experimental P-V data to 16 GPa. The experimental value of dG /dP is in excellent agreement with predictions based on elasticity systematics. Theoretical models are not yet able to replicate the measured values of K' 0 and G' 0.

  15. Comparison of elastic and inelastic analyses

    International Nuclear Information System (INIS)

    Ammerman, D.J.; Heinstein, M.W.; Wellman, G.W.

    1992-01-01

    The use of inelastic analysis methods instead of the traditional elastic analysis methods in the design of radioactive material (RAM) transport packagings leads to a better understanding of the response of the package to mechanical loadings. Thus, better assessment of the containment, thermal protection, and shielding integrity of the package after a structure accident event can be made. A more accurate prediction of the package response can lead to enhanced safety and also allow for a more efficient use of materials, possibly leading to a package with higher capacity or lower weight. This paper discusses the advantages and disadvantages of using inelastic analysis in the design of RAM shipping packages. The use of inelastic analysis presents several problems to the package designer. When using inelastic analysis the entire nonlinear response of the material must be known, including the effects of temperature changes and strain rate. Another problem is that there currently is not an acceptance criteria for this type of analysis that is approved by regulatory agencies. Inelastic analysis acceptance criteria based on failure stress, failure strain , or plastic energy density could be developed. For both elastic and inelastic analyses it is also important to include other sources of stress in the analyses, such as fabrication stresses, thermal stresses, stresses from bolt preloading, and contact stresses at material interfaces. Offsetting these added difficulties is the improved knowledge of the package behavior. This allows for incorporation of a more uniform margin of safety, which can result in weight savings and a higher level of confidence in the post-accident configuration of the package. In this paper, comparisons between elastic and inelastic analyses are made for a simple ring structure and for a package to transport a large quantity of RAM by rail (rail cask) with lead gamma shielding to illustrate the differences in the two analysis techniques

  16. Elegent—An elastic event generator

    Science.gov (United States)

    Kašpar, J.

    2014-03-01

    Although elastic scattering of nucleons may look like a simple process, it presents a long-lasting challenge for theory. Due to missing hard energy scale, the perturbative QCD cannot be applied. Instead, many phenomenological/theoretical models have emerged. In this paper we present a unified implementation of some of the most prominent models in a C++ library, moreover extended to account for effects of the electromagnetic interaction. The library is complemented with a number of utilities. For instance, programs to sample many distributions of interest in four-momentum transfer squared, t, impact parameter, b, and collision energy √{s}. These distributions at ISR, Spp¯S, RHIC, Tevatron and LHC energies are available for download from the project web site. Both in the form of ROOT files and PDF figures providing comparisons among the models. The package includes also a tool for Monte-Carlo generation of elastic scattering events, which can easily be embedded in any other program framework. Catalogue identifier: AERT_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AERT_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 10551 No. of bytes in distributed program, including test data, etc.: 126316 Distribution format: tar.gz Programming language: C++. Computer: Any in principle, tested on x86-64 architecture. Operating system: Any in principle, tested on GNU/Linux. RAM: Strongly depends on the task, but typically below 20MB Classification: 11.6. External routines: ROOT, HepMC Nature of problem: Monte-Carlo simulation of elastic nucleon-nucleon collisions Solution method: Implementation of some of the most prominent phenomenological/theoretical models providing cumulative distribution function that is used for random event generation. Running time: Strongly depends on the task, but

  17. Elasticity of semiflexible polymers in two dimensions

    Science.gov (United States)

    Prasad, Ashok; Hori, Yuko; Kondev, Jané

    2005-10-01

    We study theoretically the entropic elasticity of a semiflexible polymer, such as DNA, confined to two dimensions. Using the worm-like-chain model we obtain an exact analytical expression for the partition function of the polymer pulled at one end with a constant force. The force-extension relation for the polymer is computed in the long chain limit in terms of Mathieu characteristic functions. We also present applications to the interaction between a semiflexible polymer and a nematic field, and derive the nematic order parameter and average extension of the polymer in a strong field.

  18. pp and ̄pp elastic scattering

    Directory of Open Access Journals (Sweden)

    A. Donnachie

    1984-01-01

    Full Text Available We present an analysis of pp and ̄pp elastic scattering in terms of various exchanges. Three-gluon exchange dominates at large t, and single-pomeron exchange at small t. The dip seen in high-energy pp scattering is provided by the interference of both of these with double-pomeron exchange. We predict that this dip will not be found in high-energy ̄pp scattering. The dip that is seen in low-energy ̄pp scattering is the result of the additional presence of reggeon-pomeron exchange.

  19. Hydrogen analysis by elastic recoil spectrometry

    International Nuclear Information System (INIS)

    Tirira, J.; Trocellier, P.

    1989-01-01

    An absolute, quantitative procedure was developed to determine the hydrogen content and to describe its concentration profile in the near-surface region of solids. The experimental technique used was the elastic recoil detection analysis of protons induced by 4 He beam bombardment in the energy range <=1.8 MeV. The hydrogen content was calculated using a new recoil cross section expression. The analyses were performed in silicon crystals implanted with hydrogen at 10 keV. The implantation dose was evaluated with an accuracy of 10% and the hydrogen depth profile with that of +-10 nm around 200 nm. (author) 10 refs.; 3 figs

  20. Elastic energy for reflection-symmetric topologies

    International Nuclear Information System (INIS)

    Majumdar, A; Robbins, J M; Zyskin, M

    2006-01-01

    Nematic liquid crystals in a polyhedral domain, a prototype for bistable displays, may be described by a unit-vector field subject to tangent boundary conditions. Here we consider the case of a rectangular prism. For configurations with reflection-symmetric topologies, we derive a new lower bound for the one-constant elastic energy. For certain topologies, called conformal and anticonformal, the lower bound agrees with a previous result. For the remaining topologies, called nonconformal, the new bound is an improvement. For nonconformal topologies we derive an upper bound, which differs from the lower bound by a factor depending only on the aspect ratios of the prism

  1. On liquid vibration in elastic containers

    International Nuclear Information System (INIS)

    Priehn, F.

    1984-01-01

    Numerical methods of calculation for containers made of circular rings of any crossection are derived for containers which are filled with incompressible and also with compressible liquids. This is done neglecting the formation of waves on the liquid surface, and by using a simplified mechanical model for calculations for the elastic walls. Using a developed Fourier series in the circumferential direction, this leads to a plane model and one obtains a very compact system of equations, which give an opportunity of studying the individual effects very economically. (orig./HP) [de

  2. Elastic lattice in an incommensurate background

    International Nuclear Information System (INIS)

    Dickman, R.; Chudnovsky, E.M.

    1995-01-01

    We study a harmonic triangular lattice, which relaxes in the presence of an incommensurate short-wavelength potential. Monte Carlo simulations reveal that the elastic lattice exhibits only short-ranged translational correlations, despite the absence of defects in either lattice. Extended orientational order, however, persists in the presence of the background. Translational correlation lengths exhibit approximate power-law dependence upon cooling rate and background strength. Our results may be relevant to Wigner crystals, atomic monolayers on crystals surfaces, and flux-line and magnetic bubble lattices

  3. Elastic lattice in a random potential

    Energy Technology Data Exchange (ETDEWEB)

    Chudnovsky, E.M.; Dickman, R. [Department of Physics and Astronomy, Lehman College, CUNY, Bedford Park Boulevard West, Bronx, New York 10468-1589 (United States)

    1998-02-01

    Using Monte Carlo simulations, we study the properties of an elastic triangular lattice subject to a random background potential. As the cooling rate is reduced, we observe a rather sudden crossover between two different glass phases, with exponential decay of translational correlations, the other with power-law decay. Contrary to predictions derived for continuum models, no evidence of a crossover in the mean-square displacement B(r) from the quadratic growth at small r to the logarithmic growth at large r is found. {copyright} {ital 1998} {ital The American Physical Society}

  4. Elastic lattice in a random potential

    International Nuclear Information System (INIS)

    Chudnovsky, E.M.; Dickman, R.

    1998-01-01

    Using Monte Carlo simulations, we study the properties of an elastic triangular lattice subject to a random background potential. As the cooling rate is reduced, we observe a rather sudden crossover between two different glass phases, with exponential decay of translational correlations, the other with power-law decay. Contrary to predictions derived for continuum models, no evidence of a crossover in the mean-square displacement B(r) from the quadratic growth at small r to the logarithmic growth at large r is found. copyright 1998 The American Physical Society

  5. Marginal elasticity of periodic triangulated origami

    Science.gov (United States)

    Chen, Bryan; Sussman, Dan; Lubensky, Tom; Santangelo, Chris

    Origami, the classical art of folding paper, has inspired much recent work on assembling complex 3D structures from planar sheets. Origami, and more generally hinged structures with rigid panels, where all faces are triangles have special properties due to having a bulk balance of mechanical degrees of freedom and constraints. We study two families of periodic triangulated origami structures, one based on the Miura ori and one based on a kagome-like pattern due to Ron Resch. We point out the consequences of the balance of degrees of freedom and constraints for these ''metamaterial plates'' and show how the elasticity can be tuned by changing the unit cell geometry.

  6. ELASTIC SCATTERING: How goes the Odderon?

    International Nuclear Information System (INIS)

    Fried, H.M.; Kang, Kyungsik; Tan, C-I

    1994-01-01

    Spurred by new measurements of total reaction rates and associated parameters by groups at CERN, DESY, and Fermilab, and with the scent of possible solutions to past controversies in the air, some 110 experimental and theoretical highenergy physicists gathered at Brown University (Providence, Rhode Island) for the fifth traditional 'Blois' Workshop on High-Energy Elastic and Diffractive Scattering. Very much alive is the 'Odderon' - the extra effect to explain the difference between proton-proton and proton-antiproton scattering.

  7. Applications of super elasticity in vibrational control

    International Nuclear Information System (INIS)

    Soul, H

    2005-01-01

    In this work, the possibilities of using shape memory alloys (SMA) as passive dampers devices in mechanicals vibrations problems are studied.The property that is exploited is the super elastic effect, by wich strains of the order of 10% can be obtained.The relationship between stress and strain means that this is an inelastic process.Nevertheless when load is removed the material recoveries its original dimension, presenting zero or almost zero permanent strain relative to others common materials, describing in its stress-strain diagram an important hysteretic loop.This features occurs basically because in well suited conditions the SMA can undergo martensitic transformations induced by stress.A series of uniaxial tension tests in commercial NiTi wires are performed, in order to characterize the super elastic behavior of the material.The influence of variables as ambient temperature, strain rate, strain levels and number of tension cycles accumulated are studied paying attention to the dissipative capacity of the material defined by means of the shape of the hysteretic loop.The influence on the damping capacity of the thermal effects associated with the martensitic transformation are evaluated by performing experiments at different transformation rates.Results are rationalized in terms of a model considering the interaction between a source term (heat of transformation), heat convection to the ambient and conduction along the wire.Some numerical results are obtained and discussed. For a performance evaluation in devices applications a simplified model of super elasticity is proposed.Then, the response of an elastic frame structure endowed with SMA tensors is evaluated following the model behavior when seismic movement is imposed at the base.The obtained results verify the possibility of using SMA as kernel elements in vibration control.This conclusion is experimentally verified in a prototype of the structure specially designed and constructed for this work

  8. Nonlinear surface elastic modes in crystals

    Science.gov (United States)

    Gorentsveig, V. I.; Kivshar, Yu. S.; Kosevich, A. M.; Syrkin, E. S.

    1990-03-01

    The influence of nonlinearity on shear horizontal surface elastic waves in crystals is described on the basis of the effective nonlinear Schrödinger equation. It is shown that the corresponding solutions form a set of surface modes and the simplest mode coincides with the solution proposed by Mozhaev. The higher order modes have internal frequencies caused by the nonlinearity. All these modes decay in the crystal as uoexp(- z/ zo) atz≫ zo- u o-1 ( z is the distance from the crystal surface, uo the wave amplitude at the surface). The creation of the modes from a localized surface excitation has a threshold. The stability of the modes is discussed.

  9. Elastic Scattering - Past, Present and Future

    International Nuclear Information System (INIS)

    Fazal-e-Aleem; Rashid, Haris; Tahir, Sohail Afzal

    2007-01-01

    Various aspects of elastic and diffractive scattering have been studied at Fermilab and CERN. Search for more results is ongoing at RHIC and planned at LHC. In this talk, we review the progress made so far and elaborate future prospects. Theoretical study focuses on the analysis of the available data in the light of predictions of various models with special emphasis on Eikonal picture and QCD inspired models. In the light of this analysis, various possibilities have been explored with reference to RHIC and LHC measurements

  10. Hydrodynamics and Elasticity of Charged Black Branes

    DEFF Research Database (Denmark)

    Gath, Jakob

    We consider long-wavelength perturbations of charged black branes to first order in a uidelastic derivative expansion. At first order the perturbations decouple and we treat the hydrodynamic and elastic perturbations separately. To put the results in a broader perspective, we present the rst...... as a seed solution, we obtain a class of charged black brane geometries carrying smeared Maxwell charge in Einstein-Maxwell-dilaton theory. In the specific case of ten-dimensional space-time we furthermore use T-duality to generate bent black branes with higher-form charge, including smeared D...

  11. Thermodynamic analysis of elastic-plastic deformation

    International Nuclear Information System (INIS)

    Lubarda, V.

    1981-01-01

    The complete set of constitutive equations which fully describes the behaviour of material in elastic-plastic deformation is derived on the basis of thermodynamic analysis of the deformation process. The analysis is done after the matrix decomposition of the deformation gradient is introduced into the structure of thermodynamics with internal state variables. The free energy function, is decomposed. Derive the expressions for the stress response, entropy and heat flux, and establish the evolution equation. Finally, we establish the thermodynamic restrictions of the deformation process. (Author) [pt

  12. Local Tensor Radiation Conditions For Elastic Waves

    DEFF Research Database (Denmark)

    Krenk, S.; Kirkegaard, Poul Henning

    2001-01-01

    A local boundary condition is formulated, representing radiation of elastic waves from an arbitrary point source. The boundary condition takes the form of a tensor relation between the stress at a point on an arbitrarily oriented section and the velocity and displacement vectors at the point....... The tensor relation generalizes the traditional normal incidence impedance condition by accounting for the angle between wave propagation and the surface normal and by including a generalized stiffness term due to spreading of the waves. The effectiveness of the local tensor radiation condition...

  13. Constitutive relations for non-elastic deformation

    International Nuclear Information System (INIS)

    Hart, E.W.

    1978-01-01

    A new class of constitutive equations is described for non-elastic deformation of metals. The relations are embodied in a model that has had considerable experimental investigation. The model employs two deformation state variables of which one is a scalar hardness variable and the other is a stored anelastic strain. The description is entirely in terms of real time strain rates. The model and its experimental background is discussed. The relationship to mechanical calculations and a possible extension to radiation environment is also considered. (Auth.)

  14. Optimization of directional elastic energy propagation

    DEFF Research Database (Denmark)

    Andreassen, Erik; Chang, Hannah R.; Ruzzene, Massimo

    2016-01-01

    The aim of this paper is to demonstrate how topology optimization can be used to design a periodically perforated plate, in order to obtain a tailored anisotropic group velocity profile. The main method is demonstrated on both low and high frequency bending wave propagation in an aluminum plate......, but is general in the sense that it could be used to design periodic structures with frequency dependent group velocity profiles for any kind of elastic wave propagation. With the proposed method the resulting design is manufacturable. Measurements on an optimized design compare excellently with the numerical...

  15. Converging shocks in elastic-plastic solids.

    Science.gov (United States)

    Ortega, A López; Lombardini, M; Hill, D J

    2011-11-01

    We present an approximate description of the behavior of an elastic-plastic material processed by a cylindrically or spherically symmetric converging shock, following Whitham's shock dynamics theory. Originally applied with success to various gas dynamics problems, this theory is presently derived for solid media, in both elastic and plastic regimes. The exact solutions of the shock dynamics equations obtained reproduce well the results obtained by high-resolution numerical simulations. The examined constitutive laws share a compressible neo-Hookean structure for the internal energy e=e(s)(I(1))+e(h)(ρ,ς), where e(s) accounts for shear through the first invariant of the Cauchy-Green tensor, and e(h) represents the hydrostatic contribution as a function of the density ρ and entropy ς. In the strong-shock limit, reached as the shock approaches the axis or origin r=0, we show that compression effects are dominant over shear deformations. For an isothermal constitutive law, i.e., e(h)=e(h)(ρ), with a power-law dependence e(h) is proportional to ρ(α), shock dynamics predicts that for a converging shock located at r=R(t) at time t, the Mach number increases as M is proportional to [log(1/R)](α), independently of the space index s, where s=2 in cylindrical geometry and 3 in spherical geometry. An alternative isothermal constitutive law with p(ρ) of the arctanh type, which enforces a finite density in the strong-shock limit, leads to M is proportional to R(-(s-1)) for strong shocks. A nonisothermal constitutive law, whose hydrostatic part e(h) is that of an ideal gas, is also tested, recovering the strong-shock limit M is proportional to R(-(s-1)/n(γ)) originally derived by Whitham for perfect gases, where γ is inherently related to the maximum compression ratio that the material can reach, (γ+1)/(γ-1). From these strong-shock limits, we also estimate analytically the density, radial velocity, pressure, and sound speed immediately behind the shock. While the

  16. Elastic hadron scattering and optical theorem

    CERN Document Server

    Lokajicek, Milos V.; Prochazka, Jiri

    2014-01-01

    In principle all contemporary phenomenological models of elastic hadronic scattering have been based on the assumption of optical theorem validity that has been overtaken from optics. It will be shown that the given theorem which has not been actually proved cannot be applied to short-ranged strong interactions in any case. The actual progress in description of collision processes might then exist only if the initial states are specified on the basis of impact parameter values of colliding particles and probability dependence on this parameter is established.

  17. Remaking the Elasticity of Consumer Wants

    DEFF Research Database (Denmark)

    Pallesen, Trine; Jenle, Rasmus Ploug

    The paper analyses a smart grid project named EcoGrid, the paper shows how a large market experiment is used to present a solution to the intermittency problem associated with wind power: How to balance supply and demand when electricity production 'follows the wind'? It is shown how electricity...... consumption is sought moved away from periods of peak consumption, and towards periods of peak production, by making consumers sensitive to ongoing changes in price. The study takes a pragmatic stance, applying concepts from the sociology of markets. The paper shows how the price elasticity of a good...

  18. Martensitic textures: Multiscale consequences of elastic compatibility

    International Nuclear Information System (INIS)

    Shenoy, S.R.; Lookman, T.; Saxena, A.; Bishop, A.R.

    2001-03-01

    We show that a free energy entirely in the order-parameter strain variable(s), rather than the displacement field, provides a unified understanding of martensitic textures. We use compatibility equations, linking the strain tensor components in the bulk and at interfaces, that induce anisotropic order-parameter strain interactions. These two long-range bulk/interface potentials, together with local compositional fluctuations, drive the formation of global elastic textures. Relaxational simulations show the spontaneous formation (and evolution under stress/temperature quenches) of equal width parallel twins, branched twins, and tweed, including characteristic scaling of twin width with twin length. (author)

  19. Kuni 10 kaitseväelast Malisse

    Index Scriptorium Estoniae

    2013-01-01

    Valitsus saatis riigikokku eelnõu, mille kohaselt võib Eesti saata Euroopa Liidu väljaõppemissioonile Malis kuni 10 kaitseväelast. Kaitsevägi panustaks staabiohvitseridega, kelle peamiseks ülesandeks on osaleda Mali üksustele erinevate riikide poolt läbiviidava väljaõppe planeerimise ja nõustamise protsessides ning väljaõppemeeskonnaga, kelle ülesandeks on viia läbi Mali üksustele mitmesugust sõjalist väljaõpet

  20. Development of scaffold-free elastic cartilaginous constructs with structural similarities to auricular cartilage.

    Science.gov (United States)

    Giardini-Rosa, Renata; Joazeiro, Paulo P; Thomas, Kathryn; Collavino, Kristina; Weber, Joanna; Waldman, Stephen D

    2014-03-01

    External ear reconstruction with autologous cartilage still remains one of the most difficult problems in the fields of plastic and reconstructive surgery. As the absence of tissue vascularization limits the ability to stimulate new tissue growth, relatively few surgical approaches are currently available (alloplastic implants or sculpted autologous cartilage grafts) to repair or reconstruct the auricle (or pinna) as a result of traumatic loss or congenital absence (e.g., microtia). Alternatively, tissue engineering can offer the potential to grow autogenous cartilage suitable for implantation. While tissue-engineered auricle cartilage constructs can be created, a substantial number of cells are required to generate sufficient quantities of tissue for reconstruction. Similarly, as routine cell expansion can elicit negative effects on chondrocyte function, we have developed an approach to generate large-sized engineered auricle constructs (≥3 cm(2)) directly from a small population of donor cells (20,000-40,000 cells/construct). Using rabbit donor cells, the developed bioreactor-cultivated constructs adopted structural-like characteristics similar to native auricular cartilage, including the development of distinct cartilaginous and perichondrium-like regions. Both alterations in media composition and seeding density had profound effects on the formation of engineered elastic tissue constructs in terms of cellularity, extracellular matrix accumulation, and tissue structure. Higher seeding densities and media containing sodium bicarbonate produced tissue constructs that were closer to the native tissue in terms of structure and composition. Future studies will be aimed at improving the accumulation of specific tissue constituents and determining the clinical effectiveness of this approach using a reconstructive animal model.

  1. Morphology, surface roughness, electron inelastic and quasi-elastic scattering in elastic peak electron spectroscopy of polymers

    International Nuclear Information System (INIS)

    Lesiak, B.; Kosinski, A.; Nowakowski, R.; Koever, L.; Toth, J.; Varga, D.; Cserny, I.; Sulyok, A.; Gergely, G.

    2006-01-01

    Complete text of publication follows. Elastic peak electron spectroscopy (EPES) deals with the interaction of electrons with atoms of a solid surface, studying the distribution of electrons backscattered elastically. The nearest vicinity of the elastic peak, (low kinetic energy region) reflects both, electron inelastic and quasi-elastic processes. The incident electrons produce surface excitations, inducing surface plasmons with the corresponding loss peaks separated by 1 - 20 eV energy from the elastic peak. Quasi-elastic losses result from the recoil of scattering atoms of different atomic number, Z. The respective energy shift and Doppler broadening of the elastic peak depend on Z, the primary electron energy, E, and the measurement geometry. Quantitative surface analytical application of EPES, such as determination of parameters describing electron transport, requires a comparison of experimental data with corresponding data derived from Monte Carlo (MC) simulation. Several problems occur in EPES studies of polymers. The intensity of elastic peak, considered in quantitative surface analysis, is influenced by both, the inelastic and quasi-elastic scattering processes (especially for hydrogen scattering atoms and primary electron energy above 1000 eV). An additional factor affecting the elastic peak intensity is the surface morphology and roughness. The present work compares the effect of these factors on the elastic peak intensity for selected polymers (polyethylene, polyaniline and polythiophenes). X-ray photoelectron spectroscopy (XPS) and helium pycnometry are applied for deriving the surface atomic composition and the bulk density, while scanning electron microscopy (SEM) and atomic force microscopy (AFM) for determining surface morphology and roughness. According to presented results, the influence of surface morphology and roughness is larger than those of surface excitations or recoil of hydrogen atoms. The component due to recoil of hydrogen atoms can be

  2. Low elastic modulus titanium–nickel scaffolds for bone implants

    International Nuclear Information System (INIS)

    Li, Jing; Yang, Hailin; Wang, Huifeng; Ruan, Jianming

    2014-01-01

    The superelastic nature of repeating the human bones is crucial to the ideal artificial biomedical implants to ensure smooth load transfer and foster the ingrowth of new bone tissues. Three dimensional interconnected porous TiNi scaffolds, which have the tailorable porous structures with micro-hole, were fabricated by slurry immersing with polymer sponge and sintering method. The crystallinity and phase composition of scaffolds were studied by X-ray diffraction. The pore morphology, size and distribution in the scaffolds were characterized by scanning electron microscopy. The porosity ranged from 65 to 72%, pore size was 250–500 μm. Compressive strength and elastic modulus of the scaffolds were ∼ 73 MPa and ∼ 3GPa respectively. The above pore structural and mechanical properties are similar to those of cancellous bone. In the initial cell culture test, osteoblasts adhered well to the scaffold surface during a short time, and then grew smoothly into the interconnected pore channels. These results indicate that the porous TiNi scaffolds fabricated by this method could be bone substitute materials. - Highlights: • A novel approach for the fabrication of porous TiNi scaffolds • Macroporous structures are replicated from the polymer sponge template. • The pore characteristics and mechanical properties of TiNi scaffolds agree well with the requirement of trabecular bone. • Cytocompatibility of TiNi scaffolds is assessed, and it closely associated with pore property

  3. Unraveling complex nonlinear elastic behaviors in rocks using dynamic acousto-elasticity

    Science.gov (United States)

    Riviere, J.; Guyer, R.; Renaud, G.; TenCate, J. A.; Johnson, P. A.

    2012-12-01

    In comparison with standard nonlinear ultrasonic methods like frequency mixing or resonance based measurements that allow one to extract average, bulk variations of modulus and attenuation versus strain level, dynamic acousto-elasticity (DAE) allows to obtain the elastic behavior over the entire dynamic cycle, detailing the full nonlinear behavior under tension and compression, including hysteresis and memory effects. This method consists of exciting a sample in Bulk-mode resonance at strains of 10-7 to 10-5 and simultaneously probing with a sequence of high frequency, low amplitude pulses. Time of flight and amplitudes of these pulses, respectively related to nonlinear elastic and dissipative parameters, can be plotted versus vibration strain level. Despite complex nonlinear signatures obtained for most rocks, it can be shown that for low strain amplitude (Pasqualini et al., JGR 2007), but not with the extreme detail of elasticity provided by DAE. Previous quasi-static measurements made in Berea sandstone (Claytor et al, GRL 2009), show that the hysteretic behavior disappears when the protocol is performed at a very low strain-rate (static limit). Therefore, future work will aim at linking quasi-static and dynamic observations, i.e. the frequency or strain-rate dependence, in order to understand underlying physical phenomena.

  4. Angular distributions of elastic and quasi elastic heavy-ion collisions. Pattern analysis

    International Nuclear Information System (INIS)

    Da Silveira, R.

    1980-06-01

    The emergence, as well as the evolution, of the most typical patterns observed in the angular distributions of elastic scattering and surface transfer between heavy-nuclei, is discussed. Starting from the semi-classical approximation, Thom's classification theorem is evoked to further illuminate the connection between these patterns and the collision parameters

  5. Token-Aware Completion Functions for Elastic Processor Verification

    Directory of Open Access Journals (Sweden)

    Sudarshan K. Srinivasan

    2009-01-01

    Full Text Available We develop a formal verification procedure to check that elastic pipelined processor designs correctly implement their instruction set architecture (ISA specifications. The notion of correctness we use is based on refinement. Refinement proofs are based on refinement maps, which—in the context of this problem—are functions that map elastic processor states to states of the ISA specification model. Data flow in elastic architectures is complicated by the insertion of any number of buffers in any place in the design, making it hard to construct refinement maps for elastic systems in a systematic manner. We introduce token-aware completion functions, which incorporate a mechanism to track the flow of data in elastic pipelines, as a highly automated and systematic approach to construct refinement maps. We demonstrate the efficiency of the overall verification procedure based on token-aware completion functions using six elastic pipelined processor models based on the DLX architecture.

  6. Indentation of elastically soft and plastically compressible solids

    DEFF Research Database (Denmark)

    Needleman, A.; Tvergaard, Viggo; Van der Giessen, E.

    2015-01-01

    rapidly for small deviations from plastic incompressibility and then decreases rather slowly for values of the plastic Poisson's ratio less than 0.25. For both soft elasticity and plastic compressibility, the main reason for the lower values of indentation hardness is related to the reduction......The effect of soft elasticity, i.e., a relatively small value of the ratio of Young's modulus to yield strength and plastic compressibility on the indentation of isotropically hardening elastic-viscoplastic solids is investigated. Calculations are carried out for indentation of a perfectly sticking...... rigid sharp indenter into a cylinder modeling indentation of a half space. The material is characterized by a finite strain elastic-viscoplastic constitutive relation that allows for plastic as well as elastic compressibility. Both soft elasticity and plastic compressibility significantly reduce...

  7. Pricing perpetual American options under multiscale stochastic elasticity of variance

    International Nuclear Information System (INIS)

    Yoon, Ji-Hun

    2015-01-01

    Highlights: • We study the effects of the stochastic elasticity of variance on perpetual American option. • Our SEV model consists of a fast mean-reverting factor and a slow mean-revering factor. • A slow scale factor has a very significant impact on the option price. • We analyze option price structures through the market prices of elasticity risk. - Abstract: This paper studies pricing the perpetual American options under a constant elasticity of variance type of underlying asset price model where the constant elasticity is replaced by a fast mean-reverting Ornstein–Ulenbeck process and a slowly varying diffusion process. By using a multiscale asymptotic analysis, we find the impact of the stochastic elasticity of variance on the option prices and the optimal exercise prices with respect to model parameters. Our results enhance the existing option price structures in view of flexibility and applicability through the market prices of elasticity risk

  8. Vanadium and heat treatments effect on elastic characteristics of niobium

    International Nuclear Information System (INIS)

    Vasil'eva, E.V.; Tret'yakov, V.I.; Prokoshkin, D.A.; Pustovalov, V.A.

    1975-01-01

    The effect of vanadium content and of heat treatment conditions on the elastic properties of niobium at temperatures of 20 to 800 deg C was studied. Nb-V alloys were produced by binary vacuum remelting. The Nb-V alloys have been then subjected to thermal treatment. The total degree of deformation amounts to about 95%. The specimens were tested with a view to determine their microhardness, specific electric resistance, elasticity limit and modulus of elasticity. The elastic limit of niobium rises when alloyed with vanadium. With the increase of vanadium content the elastic limit of the alloy becomes greater. Pre-crystallization annealing at 600 - 700 deg C considerably increases the elastic limit, which is explained by development of the thermally activated processes leading to a decrease of dislocation mobility and thereby to a strengthening of the alloy

  9. Noninvasive Vascular Displacement Estimation for Relative Elastic Modulus Reconstruction in Transversal Imaging Planes

    Directory of Open Access Journals (Sweden)

    Chris L. de Korte

    2013-03-01

    Full Text Available Atherosclerotic plaque rupture can initiate stroke or myocardial infarction. Lipid-rich plaques with thin fibrous caps have a higher risk to rupture than fibrotic plaques. Elastic moduli differ for lipid-rich and fibrous tissue and can be reconstructed using tissue displacements estimated from intravascular ultrasound radiofrequency (RF data acquisitions. This study investigated if modulus reconstruction is possible for noninvasive RF acquisitions of vessels in transverse imaging planes using an iterative 2D cross-correlation based displacement estimation algorithm. Furthermore, since it is known that displacements can be improved by compounding of displacements estimated at various beam steering angles, we compared the performance of the modulus reconstruction with and without compounding. For the comparison, simulated and experimental RF data were generated of various vessel-mimicking phantoms. Reconstruction errors were less than 10%, which seems adequate for distinguishing lipid-rich from fibrous tissue. Compounding outperformed single-angle reconstruction: the interquartile range of the reconstructed moduli for the various homogeneous phantom layers was approximately two times smaller. Additionally, the estimated lateral displacements were a factor of 2–3 better matched to the displacements corresponding to the reconstructed modulus distribution. Thus, noninvasive elastic modulus reconstruction is possible for transverse vessel cross sections using this cross-correlation method and is more accurate with compounding.

  10. Elastic metamaterials and dynamic homogenization: a review

    Directory of Open Access Journals (Sweden)

    Ankit Srivastava

    2015-01-01

    Full Text Available In this paper, we review the recent advances which have taken place in the understanding and applications of acoustic/elastic metamaterials. Metamaterials are artificially created composite materials which exhibit unusual properties that are not found in nature. We begin with presenting arguments from discrete systems which support the case for the existence of unusual material properties such as tensorial and/or negative density. The arguments are then extended to elastic continuums through coherent averaging principles. The resulting coupled and nonlocal homogenized relations, called the Willis relations, are presented as the natural description of inhomogeneous elastodynamics. They are specialized to Bloch waves propagating in periodic composites and we show that the Willis properties display the unusual behavior which is often required in metamaterial applications such as the Veselago lens. We finally present the recent advances in the area of transformation elastodynamics, charting its inspirations from transformation optics, clarifying its particular challenges, and identifying its connection with the constitutive relations of the Willis and the Cosserat types.

  11. Texture and Elastic Anisotropy of Mantle Olivine

    Science.gov (United States)

    Nikitin, A. N.; Ivankina, T. I.; Bourilitchev, D. E.; Klima, K.; Locajicek, T.; Pros, Z.

    Eight olivine rock samples from different European regions were collected for neu- tron texture analyses and for P-wave velocity measurements by means of ultrasonic sounding at various confining pressures. The orientation distribution functions (ODFs) of olivine were determined and pole figures of the main crystallographic planes were calculated. The spatial P-wave velocity distributions were determined at confining pressures from 0.1 to 400 MPa and modelled from the olivine textures. In dependence upon the type of rock (xenolith or dunite) different behavior of both the P-wave veloc- ity distributions and the anisotropy coefficients with various confining pressures was observed. In order to explain the interdependence of elastic anisotropy and hydrostatic pressure, a model for polycrystalline olivine rocks was suggested, which considers the influence of the crystallographic and the mechanical textures on the elastic behaviour of the polycrystal. Since the olivine texture depends upon the active slip systems and the deformation temperature, neutron texture analyses enable us to estimate depth and thermodynamical conditions during texture formation.

  12. Elastic stability of thick auxetic plates

    International Nuclear Information System (INIS)

    Lim, Teik-Cheng

    2014-01-01

    Auxetic materials and structures exhibit a negative Poisson’s ratio while thick plates encounter shear deformation, which is not accounted for in classical plate theory. This paper investigates the effect of a negative Poisson’s ratio on thick plates that are subjected to buckling loads, taking into consideration the shear deformation using Mindlin plate theory. Using a highly accurate shear correction factor that allows for the effect of Poisson’s ratio, the elastic stability of circular and square plates are evaluated in terms of dimensionless parameters, namely the Mindlin-to-Kirchhoff critical buckling load ratio and Mindlin critical buckling load factors. Results for thick square plates reveal that both parameters increase as the Poisson’s ratio becomes more negative. In the case of thick circular plates, the Mindlin-to-Kirchhoff critical buckling load ratios and the Mindlin critical buckling load factors increase and decrease, respectively, as the Poisson’s ratio becomes more negative. The results obtained herein show that thick auxetic plates behave as thin conventional plates, and therefore suggest that the classical plate theory can be used to evaluate the elastic stability of thick plates if the Poisson’s ratio of the plate material is sufficiently negative. The results also suggest that materials with highly negative Poisson’s ratios are recommended for square plates, but not circular plates, that are subjected to buckling loads. (paper)

  13. On elastic limit margins for earthquake design

    International Nuclear Information System (INIS)

    Buchhardt, F.; Matthees, W.; Magiera, G.

    1987-01-01

    In the Federal Republic of Germany KTA rule 2201 being the basis for the design of nuclear power plants against seismic events is now under discussion for revisions. One of the main demands to modify KTA rule 2201 consists in cancelling the existing design philosophy, i.e. design against an operating basis earthquake (AEB) as well as against a safe shutdown earthquake (SEB). When using the present rule the 'lower' earthquake (AEB) can become design-predominant, since for AEB and SEB different types of load cases are to be superimposed with different safety factors. The scope of this study is to quantify by parametric analyses so-called 'elastic bearing capacity limit margins' for seismic events; hereby different seismic input criteria - conventional as well as recently proposed are taken into account to investigate the influence of eventual modifications in seismic design philosophy. This way a relation between AEB and SEB has to be defined so that SEB is just still predominant for the design while AEB still will yield to elastic behaviour. The study covers all German site conditions

  14. Wrinkling in the deflation of elastic bubbles.

    Science.gov (United States)

    Aumaitre, Elodie; Knoche, Sebastian; Cicuta, Pietro; Vella, Dominic

    2013-03-01

    The protein hydrophobin HFBII self-assembles into very elastic films at the surface of water; these films wrinkle readily upon compression. We demonstrate and study this wrinkling instability in the context of non-planar interfaces by forming HFBII layers at the surface of bubbles whose interfaces are then compressed by deflation of the bubble. By varying the initial concentration of the hydrophobin solutions, we are able to show that buckling occurs at a critical packing fraction of protein molecules on the surface. Independent experiments show that at this packing fraction the interface has a finite positive surface tension, and not zero surface tension as is usually assumed at buckling. We attribute this non-zero wrinkling tension to the finite elasticity of these interfaces. We develop a simple geometrical model for the evolution of the wrinkle length with further deflation and show that wrinkles grow rapidly near the needle (used for deflation) towards the mid-plane of the bubble. This geometrical model yields predictions for the length of wrinkles in good agreement with experiments independently of the rheological properties of the adsorbed layer.

  15. Elastic models application for thorax image registration

    International Nuclear Information System (INIS)

    Correa Prado, Lorena S; Diaz, E Andres Valdez; Romo, Raul

    2007-01-01

    This work consist of the implementation and evaluation of elastic alignment algorithms of biomedical images, which were taken at thorax level and simulated with the 4D NCAT digital phantom. Radial Basis Functions spatial transformations (RBF), a kind of spline, which allows carrying out not only global rigid deformations but also local elastic ones were applied, using a point-matching method. The applied functions were: Thin Plate Spline (TPS), Multiquadric (MQ) Gaussian and B-Spline, which were evaluated and compared by means of calculating the Target Registration Error and similarity measures between the registered images (the squared sum of intensity differences (SSD) and correlation coefficient (CC)). In order to value the user incurred error in the point-matching and segmentation tasks, two algorithms were also designed that calculate the Fiduciary Localization Error. TPS and MQ were demonstrated to have better performance than the others. It was proved RBF represent an adequate model for approximating the thorax deformable behaviour. Validation algorithms showed the user error was not significant

  16. Wrinkling in the deflation of elastic bubbles

    KAUST Repository

    Aumaitre, Elodie

    2013-03-01

    The protein hydrophobin HFBII self-assembles into very elastic films at the surface of water; these films wrinkle readily upon compression. We demonstrate and study this wrinkling instability in the context of non-planar interfaces by forming HFBII layers at the surface of bubbles whose interfaces are then compressed by deflation of the bubble. By varying the initial concentration of the hydrophobin solutions, we are able to show that buckling occurs at a critical packing fraction of protein molecules on the surface. Independent experiments show that at this packing fraction the interface has a finite positive surface tension, and not zero surface tension as is usually assumed at buckling. We attribute this non-zero wrinkling tension to the finite elasticity of these interfaces. We develop a simple geometrical model for the evolution of the wrinkle length with further deflation and show that wrinkles grow rapidly near the needle (used for deflation) towards the mid-plane of the bubble. This geometrical model yields predictions for the length of wrinkles in good agreement with experiments independently of the rheological properties of the adsorbed layer. © 2013 EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg.

  17. Wave chaos in the elastic disk.

    Science.gov (United States)

    Sondergaard, Niels; Tanner, Gregor

    2002-12-01

    The relation between the elastic wave equation for plane, isotropic bodies and an underlying classical ray dynamics is investigated. We study, in particular, the eigenfrequencies of an elastic disk with free boundaries and their connection to periodic rays inside the circular domain. Even though the problem is separable, wave mixing between the shear and pressure component of the wave field at the boundary leads to an effective stochastic part in the ray dynamics. This introduces phenomena typically associated with classical chaos as, for example, an exponential increase in the number of periodic orbits. Classically, the problem can be decomposed into an integrable part and a simple binary Markov process. Similarly, the wave equation can, in the high-frequency limit, be mapped onto a quantum graph. Implications of this result for the level statistics are discussed. Furthermore, a periodic trace formula is derived from the scattering matrix based on the inside-outside duality between eigenmodes and scattering solutions and periodic orbits are identified by Fourier transforming the spectral density.

  18. Relativistic electrodynamics of dissipative elastic media

    International Nuclear Information System (INIS)

    Kranys, M.

    1980-01-01

    A phenomenological general relativistic electrodynamics is proposed for a dissipative elastic solid which is polarizable and magnetizable and whose governing equations form a hyperbolic system. Non-stationary transport equations are proposed for dissipative fluxes (and constitutive equations of electrodynamics) containing new cross-effect terms, as required for compatibility with an entropy principle expressed by a new balance equation (including a new Gibbs equation). The dynamic equations are deduced from the unified Minkowski-Abraham-Eckart energy-momentum tensor. The theory, formed by a set of 29 (reducible to 23) partial differential equations (in special relativity) governing the material behaviour of the system characterized by generalizing the constitutive equations of quasineutral media, together with Maxwell's equations, may be referred to as the electrodynamics of dissipative elastic media (or fluid). The proposed transport laws for polarization and magnetization generalize the well-known Debye law for relaxation and show the influence of shear and bulk viscosity on polarization and magentization. Besides the form of the entropy function, the free energy function in the non-stationary regime is also formulated. (auth)

  19. Modelling of the elastic behaviour of metallic powders

    International Nuclear Information System (INIS)

    Riera, M.D.; Prado, J.M.

    1998-01-01

    In this work the elastic behaviour of metal powders compacted to different densities is studied. The authors apply a model based on the experimental observation that the elastic volumetric strain and the hydrostatic component of the applied stress are exponentially related. While a complete analysis should include both the volumetric and deviatoric components of the elastic strain, we only present here the first one. (Author) 9 refs

  20. Elastic constants and internal friction of fiber-reinforced composites

    International Nuclear Information System (INIS)

    Ledbetter, H.M.

    1982-01-01

    We review recent experimental studies at NBS on the anisotropic elastic constants and internal friction of fiber-reinforced composites. Materials that were studied include: boron-aluminum, boron-epoxy, graphite-epoxy, glass-epoxy, and aramid-epoxy. In all cases, elastic-constant direction dependence could be described by relationships developed for single crystals of homogeneous materials. Elastic stiffness and internal friction were found to vary inversely

  1. Goods-Time Elasticity of Substitution in Health Production.

    Science.gov (United States)

    Du, Juan; Yagihashi, Takeshi

    2017-11-01

    We examine how inputs for health production, in particular, medical care and health-enhancing time, are combined to improve health. The estimated elasticity of substitution from a constant elasticity of substitution production function is significantly less than one for the working-age population, rejecting the unit elasticity of substitution used in previous studies. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  2. Efficient education policy: A second-order elasticity rule

    OpenAIRE

    Richter, Wolfram F.

    2010-01-01

    Assuming a two-period model with endogenous choices of labour, education, and saving, efficient education policy is characterized for a Ramsey-like scenario in which the government is constrained to use linear instruments. It is shown that education should be effectively subsidized if, and only if, the elasticity of the earnings function is increasing in education. The strength of second-best subsidization increases in the elasticity of the elasticity of the earnings function. This second-ord...

  3. Remarks on stability of magneto-elastic shocks

    Directory of Open Access Journals (Sweden)

    Włodzimierz Domański

    2015-12-01

    Full Text Available The problem of stability of plane shock waves for a model of perfect magnetoelasticityis investigated. Important mathematical properties, like loss of strict hyperbolicityand loss of genuine nonlinearity, and their consequences for the stability ofmagneto-elastic shocks are discussed. It is shown that some of these shocks do not satisfyclassical Lax stability conditions. Both compressible and incompressible models ofmagneto-elasticity are discussed.[b]Keywords[/b]: perfect magneto-elasticity, shock waves, stability conditions

  4. Study of elastic waves with a camouflage explosion

    Energy Technology Data Exchange (ETDEWEB)

    Dunin, S.Z.; Nagornov, O.V.; Popov, E.A.

    1982-01-01

    Examination is made of the problem concerning the study of elastic waves with an explosion in a porous medium with consideration given to the effect of dilation. Investigation is made of the character of the study of elastic energy at various moments. An analysis is made of the spectral properties of the investigated seismic signal, the effect of strong parameters of the medium, porosity, and the coefficient of dilation on the magnitude of elastic energy, which is emitted during an explosion.

  5. Vitamin A deficiency alters the pulmonary parenchymal elastic modulus and elastic fiber concentration in rats

    Directory of Open Access Journals (Sweden)

    Holmes Amey J

    2005-07-01

    Full Text Available Abstract Background Bronchial hyperreactivity is influenced by properties of the conducting airways and the surrounding pulmonary parenchyma, which is tethered to the conducting airways. Vitamin A deficiency (VAD is associated with an increase in airway hyperreactivity in rats and a decrease in the volume density of alveoli and alveolar ducts. To better define the effects of VAD on the mechanical properties of the pulmonary parenchyma, we have studied the elastic modulus, elastic fibers and elastin gene-expression in rats with VAD, which were supplemented with retinoic acid (RA or remained unsupplemented. Methods Parenchymal mechanics were assessed before and after the administration of carbamylcholine (CCh by determining the bulk and shear moduli of lungs that that had been removed from rats which were vitamin A deficient or received a control diet. Elastin mRNA and insoluble elastin were quantified and elastic fibers were enumerated using morphometric methods. Additional morphometric studies were performed to assess airway contraction and alveolar distortion. Results VAD produced an approximately 2-fold augmentation in the CCh-mediated increase of the bulk modulus and a significant dampening of the increase in shear modulus after CCh, compared to vitamin A sufficient (VAS rats. RA-supplementation for up to 21 days did not reverse the effects of VAD on the elastic modulus. VAD was also associated with a decrease in the concentration of parenchymal elastic fibers, which was restored and was accompanied by an increase in tropoelastin mRNA after 12 days of RA-treatment. Lung elastin, which was resistant to 0.1 N NaOH at 98°, decreased in VAD and was not restored after 21 days of RA-treatment. Conclusion Alterations in parenchymal mechanics and structure contribute to bronchial hyperreactivity in VAD but they are not reversed by RA-treatment, in contrast to the VAD-related alterations in the airways.

  6. Bulk solitary waves in elastic solids

    Science.gov (United States)

    Samsonov, A. M.; Dreiden, G. V.; Semenova, I. V.; Shvartz, A. G.

    2015-10-01

    A short and object oriented conspectus of bulk solitary wave theory, numerical simulations and real experiments in condensed matter is given. Upon a brief description of the soliton history and development we focus on bulk solitary waves of strain, also known as waves of density and, sometimes, as elastic and/or acoustic solitons. We consider the problem of nonlinear bulk wave generation and detection in basic structural elements, rods, plates and shells, that are exhaustively studied and widely used in physics and engineering. However, it is mostly valid for linear elasticity, whereas dynamic nonlinear theory of these elements is still far from being completed. In order to show how the nonlinear waves can be used in various applications, we studied the solitary elastic wave propagation along lengthy wave guides, and remarkably small attenuation of elastic solitons was proven in physical experiments. Both theory and generation for strain soliton in a shell, however, remained unsolved problems until recently, and we consider in more details the nonlinear bulk wave propagation in a shell. We studied an axially symmetric deformation of an infinite nonlinearly elastic cylindrical shell without torsion. The problem for bulk longitudinal waves is shown to be reducible to the one equation, if a relation between transversal displacement and the longitudinal strain is found. It is found that both the 1+1D and even the 1+2D problems for long travelling waves in nonlinear solids can be reduced to the Weierstrass equation for elliptic functions, which provide the solitary wave solutions as appropriate limits. We show that the accuracy in the boundary conditions on free lateral surfaces is of crucial importance for solution, derive the only equation for longitudinal nonlinear strain wave and show, that the equation has, amongst others, a bidirectional solitary wave solution, which lead us to successful physical experiments. We observed first the compression solitary wave in the

  7. Sound radiation contrast in MR phase images. Method for the representation of elasticity, sound damping, and sound impedance changes

    International Nuclear Information System (INIS)

    Radicke, Marcus

    2009-01-01

    The method presented in this thesis combines ultrasound techniques with the magnetic-resonance tomography (MRT). An ultrasonic wave generates in absorbing media a static force in sound-propagation direction. The force leads at sound intensities of some W/cm 2 and a sound frequency in the lower MHz range to a tissue shift in the micrometer range. This tissue shift depends on the sound power, the sound frequency, the sound absorption, and the elastic properties of the tissue. A MRT sequence of the Siemens Healthcare AG was modified so that it measures (indirectly) the tissue shift, codes as grey values, and presents as 2D picture. By means of the grey values the sound-beam slope in the tissue can be visualized, and so additionally sound obstacles (changes of the sound impedance) can be detected. By the MRT images token up spatial changes of the tissue parameters sound absorption and elasticity can be detected. In this thesis measurements are presented, which show the feasibility and future chances of this method especially for the mammary-cancer diagnostics. [de

  8. X-Ray Elastic Constants for Cubic Materials

    Energy Technology Data Exchange (ETDEWEB)

    Malen, K

    1974-10-15

    The stress-strain relation to be used in X-ray stress measurements in anisotropic texture-free media is studied. The method for evaluation of appropriate elastic constants for a cubic medium is described. Some illustrative numerical examples have been worked out including line broadening due to elastic anisotropy. The elastic stress and strain compatibility at grain boundaries is taken into account using Kroner's method. These elastic constants obviously only apply when no internal stresses due to plastic deformation are present. The case of reorientation of free interstitials in the stress field can be taken into account

  9. Mimicking the effect of gravity using an elastic membrane

    International Nuclear Information System (INIS)

    Wu, Yecun; Zhu, Changqing; Wang, Yijun; Shi, Qingfan

    2014-01-01

    Comparing astrospace with an elastic membrane is an interesting analogy but it lacks a theoretical basis and experimental support. We develop a theoretical model that brings to light the relationship between the conceptual model of a gravity well and an elastic deformation equation of a membrane supporting a heavy ball, and further derive the ‘gravitational constant’ for such a small ‘elastic space’. The experimental data obtained are consistent with the prediction of our model, in mimicking the revolution of a small planet. Teaching practice shows that using an elastic membrane is a simple, intuitive and reliable method to enhance the quality of learning about the effect of gravity. (paper)

  10. A first-principles approach to finite temperature elastic constants

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Y; Wang, J J; Zhang, H; Manga, V R; Shang, S L; Chen, L-Q; Liu, Z-K [Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802 (United States)

    2010-06-09

    A first-principles approach to calculating the elastic stiffness coefficients at finite temperatures was proposed. It is based on the assumption that the temperature dependence of elastic stiffness coefficients mainly results from volume change as a function of temperature; it combines the first-principles calculations of elastic constants at 0 K and the first-principles phonon theory of thermal expansion. Its applications to elastic constants of Al, Cu, Ni, Mo, Ta, NiAl, and Ni{sub 3}Al from 0 K up to their respective melting points show excellent agreement between the predicted values and existing experimental measurements.

  11. X-Ray Elastic Constants for Cubic Materials

    Energy Technology Data Exchange (ETDEWEB)

    Malen, K.

    1974-10-15

    The stress-strain relation to be used in X-ray stress measurements in anisotropic texture-free media is studied. The method for evaluation of appropriate elastic constants for a cubic medium is described. Some illustrative numerical examples have been worked out including line broadening due to elastic anisotropy. The elastic stress and strain compatibility at grain boundaries is taken into account using Kroner's method. These elastic constants obviously only apply when no internal stresses due to plastic deformation are present. The case of reorientation of free interstitials in the stress field can be taken into account

  12. X-Ray Elastic Constants for Cubic Materials

    International Nuclear Information System (INIS)

    Malen, K.

    1974-10-01

    The stress-strain relation to be used in X-ray stress measurements in anisotropic texture-free media is studied. The method for evaluation of appropriate elastic constants for a cubic medium is described. Some illustrative numerical examples have been worked out including line broadening due to elastic anisotropy. The elastic stress and strain compatibility at grain boundaries is taken into account using Kroner's method. These elastic constants obviously only apply when no internal stresses due to plastic deformation are present. The case of reorientation of free interstitials in the stress field can be taken into account

  13. Filtering of elastic waves by opal-based hypersonic crystal.

    Science.gov (United States)

    Salasyuk, Alexey S; Scherbakov, Alexey V; Yakovlev, Dmitri R; Akimov, Andrey V; Kaplyanskii, Alexander A; Kaplan, Saveliy F; Grudinkin, Sergey A; Nashchekin, Alexey V; Pevtsov, Alexander B; Golubev, Valery G; Berstermann, Thorsten; Brüggemann, Christian; Bombeck, Michael; Bayer, Manfred

    2010-04-14

    We report experiments in which high quality silica opal films are used as three-dimensional hypersonic crystals in the 10 GHz range. Controlled sintering of these structures leads to well-defined elastic bonding between the submicrometer-sized silica spheres, due to which a band structure for elastic waves is formed. The sonic crystal properties are studied by injection of a broadband elastic wave packet with a femtosecond laser. Depending on the elastic bonding strength, the band structure separates long-living surface acoustic waves with frequencies in the complete band gap from bulk waves with band frequencies that propagate into the crystal leading to a fast decay.

  14. Elastic and optical behaviour of some europium monochalcogenides

    International Nuclear Information System (INIS)

    Islam, A.K.M.A.; Shahdatullah, M.S.

    1994-11-01

    A study of the elastic and optical properties of some Eu-monochalcogenides with NaCl structure has been carried out in this paper. Various anharmonic properties e.g. thermal expansion, third order elastic constants, Grueneisen parameter, and the pressure and temperature derivatives of second order elastic constants of EuS and EuO are also studied. A comparison of the calculated elastic and dielectric properties with the available experimental results and other theoretical estimates gives an indication of the applicability of the methods applied. (author). 49 refs, 3 figs, 3 tabs

  15. A first-principles approach to finite temperature elastic constants

    International Nuclear Information System (INIS)

    Wang, Y; Wang, J J; Zhang, H; Manga, V R; Shang, S L; Chen, L-Q; Liu, Z-K

    2010-01-01

    A first-principles approach to calculating the elastic stiffness coefficients at finite temperatures was proposed. It is based on the assumption that the temperature dependence of elastic stiffness coefficients mainly results from volume change as a function of temperature; it combines the first-principles calculations of elastic constants at 0 K and the first-principles phonon theory of thermal expansion. Its applications to elastic constants of Al, Cu, Ni, Mo, Ta, NiAl, and Ni 3 Al from 0 K up to their respective melting points show excellent agreement between the predicted values and existing experimental measurements.

  16. Non-linear theory of elasticity and optimal design

    CERN Document Server

    Ratner, LW

    2003-01-01

    In order to select an optimal structure among possible similar structures, one needs to compare the elastic behavior of the structures. A new criterion that describes elastic behavior is the rate of change of deformation. Using this criterion, the safe dimensions of a structure that are required by the stress distributed in a structure can be calculated. The new non-linear theory of elasticity allows one to determine the actual individual limit of elasticity/failure of a structure using a simple non-destructive method of measurement of deformation on the model of a structure while presently it

  17. Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel.

    Science.gov (United States)

    Lee, Ho-Joon; Son, Myung Jin; Ahn, Jiwon; Oh, Soo Jin; Lee, Mihee; Kim, Ansoon; Jeung, Yun-Ji; Kim, Han-Gyeul; Won, Misun; Lim, Jung Hwa; Kim, Nam-Soon; Jung, Cho-Rock; Chung, Kyung-Sook

    2017-12-01

    Current in vitro liver models provide three-dimensional (3-D) microenvironments in combination with tissue engineering technology and can perform more accurate in vivo mimicry than two-dimensional models. However, a human cell-based, functionally mature liver model is still desired, which would provide an alternative to animal experiments and resolve low-prediction issues on species differences. Here, we prepared hybrid hydrogels of varying elasticity and compared them with a normal liver, to develop a more mature liver model that preserves liver properties in vitro. We encapsulated HepaRG cells, either alone or with supporting cells, in a biodegradable hybrid hydrogel. The elastic modulus of the 3D liver dynamically changed during culture due to the combined effects of prolonged degradation of hydrogel and extracellular matrix formation provided by the supporting cells. As a result, when the elastic modulus of the 3D liver model converges close to that of the in vivo liver (≅ 2.3 to 5.9 kPa), both phenotypic and functional maturation of the 3D liver were realized, while hepatic gene expression, albumin secretion, cytochrome p450-3A4 activity, and drug metabolism were enhanced. Finally, the 3D liver model was expanded to applications with embryonic stem cell-derived hepatocytes and primary human hepatocytes, and it supported prolonged hepatocyte survival and functionality in long-term culture. Our model represents critical progress in developing a biomimetic liver system to simulate liver tissue remodeling, and provides a versatile platform in drug development and disease modeling, ranging from physiology to pathology. We provide a functionally improved 3D liver model that recapitulates in vivo liver stiffness. We have experimentally addressed the issues of orchestrated effects of mechanical compliance, controlled matrix formation by stromal cells in conjunction with hepatic differentiation, and functional maturation of hepatocytes in a dynamic 3D

  18. Mixed Connective Tissue Disease

    Science.gov (United States)

    Mixed connective tissue disease Overview Mixed connective tissue disease has signs and symptoms of a combination of disorders — primarily lupus, scleroderma and polymyositis. For this reason, mixed connective tissue disease ...

  19. Undifferentiated Connective Tissue Disease

    Science.gov (United States)

    ... Home Conditions Undifferentiated Connective Tissue Disease (UCTD) Undifferentiated Connective Tissue Disease (UCTD) Make an Appointment Find a Doctor ... by Barbara Goldstein, MD (February 01, 2016) Undifferentiated connective tissue disease (UCTD) is a systemic autoimmune disease. This ...

  20. Soft Tissue Sarcoma

    Science.gov (United States)

    ... muscles, tendons, fat, and blood vessels. Soft tissue sarcoma is a cancer of these soft tissues. There ... have certain genetic diseases. Doctors diagnose soft tissue sarcomas with a biopsy. Treatments include surgery to remove ...