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Sample records for einstein involving human

  1. Coherence, Abstraction, and Personal Involvement: Albert Einstein, Physicist and Humanist.

    Science.gov (United States)

    Ne'eman, Yuval

    1979-01-01

    Reviews Einstein's main contributions to physics, and analyzes the importance of a coherent body of theory. Einstein's involvement in nonscientific issues such as nuclear disarmament is also included. (HM)

  2. Einstein

    CERN Document Server

    Smith, Peter D

    2003-01-01

    Albert Einstein re-wrote the textbooks of science in 1905: physics since has been little more than a series of footnotes to the theories of a 26-year-old patent-office clerk. Einstein's science and emotional life come together in this vivid portrait of a rebellious and contradictory figure, a pacifist whose legendary equation E=mc2 opened scientists' eyes to the terrible power within every atom. 'To punish me for my contempt for authority,' he lamented, 'Fate has made me an authority myself.'

  3. Albert Einstein, the human side glimpses from his archives

    CERN Document Server

    Einstein, Albert; Hoffmann, Banesh

    2013-01-01

    Modesty, humor, compassion, and wisdom are the traits most evident in this illuminating selection of personal papers from the Albert Einstein Archives. The illustrious physicist wrote as thoughtfully to an Ohio fifth-grader, distressed by her discovery that scientists classify humans as animals, as to a Colorado banker who asked whether Einstein believed in a personal God. Witty rhymes, an exchange with Queen Elizabeth of Belgium about fine music, and expressions of his devotion to Zionism are but some of the highlights found in this warm and enriching book.

  4. The Einstein Center for Epigenomics: studying the role of epigenomic dysregulation in human disease.

    Science.gov (United States)

    McLellan, Andrew S; Dubin, Robert A; Jing, Qiang; Maqbool, Shahina B; Olea, Raul; Westby, Gael; Broin, Pilib Ó; Fazzari, Melissa J; Zheng, Deyou; Suzuki, Masako; Greally, John M

    2009-10-01

    There is increasing interest in the role of epigenetic and transcriptional dysregulation in the pathogenesis of a range of human diseases, not just in the best-studied example of cancer. It is, however, quite difficult for an individual investigator to perform these studies, as they involve genome-wide molecular assays combined with sophisticated computational analytical approaches of very large datasets that may be generated from various resources and technologies. In 2008, the Albert Einstein College of Medicine in New York, USA established a Center for Epigenomics to facilitate the research programs of its investigators, providing shared resources for genome-wide assays and for data analysis. As a result, several avenues of research are now expanding, with cancer epigenomics being complemented by studies of the epigenomics of infectious disease and a neuroepigenomics program.

  5. Einstein today

    International Nuclear Information System (INIS)

    Aspect, A.; Grangier, Ph.; Bouchet, F.R.; Brunet, E.; Derrida, B.; Cohen-Tannoudji, C.; Dalibard, J.; Laloe, F.; Damour, Th.; Darrigol, O.; Pocholle, J.P.

    2005-01-01

    The most important contributions of Einstein involve 5 fields of physics : the existence of quanta (light quanta, stimulated radiation emission and Bose-Einstein condensation), relativity, fluctuations (Brownian motion and thermodynamical fluctuations), the basis of quantum physics and cosmology (cosmological constant and the expansion of the universe). Diverse and renowned physicists have appreciated the development of modern physics from Einstein's ideas to the knowledge of today. This book is a collective book that gathers their work under 7 chapters: 1) 1905, a new beginning; 2) from the Einstein, Podolsky and Rosen's article to quantum information (cryptography and quantum computers); 3) the Bose-Einstein condensation in gases; 4) from stimulated emission to the today's lasers; 5) Brownian motion and the fluctuation-dissipation theory; 6) general relativity; and 7) cosmology. (A.C.)

  6. Continuous atom laser with Bose-Einstein condensates involving three-body interactions

    Energy Technology Data Exchange (ETDEWEB)

    Carpentier, A V; Michinel, H; Novoa, D [Area de Optica, Facultade de Ciencias de Ourense, Universidade de Vigo, As Lagoas s/n, Ourense, ES-32004 (Spain); Olivieri, D N, E-mail: avcarpentier@uvigo.e [Area de Linguaxes e sistemas informaticos, Escola Superior de EnxenerIa Informatica, Universidade de Vigo, As Lagoas s/n, Ourense, ES-32004 (Spain)

    2010-05-28

    We demonstrate, through numerical simulations, the emission of a coherent continuous matter wave of constant amplitude from a Bose-Einstein condensate in a shallow optical dipole trap. The process is achieved by spatial control of the variations of the scattering length along the trapping axis, including elastic three-body interactions due to dipole interactions. In our approach, the outcoupling mechanism is atomic interactions, and thus, the trap remains unaltered. We calculate analytically the parameters for the experimental implementation of this continuous wave atom laser.

  7. Einstein today; Einstein aujourd'hui

    Energy Technology Data Exchange (ETDEWEB)

    Aspect, A.; Grangier, Ph. [Centre National de la Recherche Scientifique (CNRS), Lab. Charles Fabry de l' Institut d' Optique a Orsay, 91 - Orsay (France); Bouchet, F.R. [Institut d' Astrophysique de Paris, CNRS, 75 - Paris (France); Brunet, E.; Derrida, B. [Universite Pierre et Marie Curie, Ecole Normale Superieure, 75 - Paris (France); Cohen-Tannoudji, C. [Academie des Sciences, 75 - Paris (France); Dalibard, J.; Laloe, F. [Laboratoire Kastler Brossel. UMR 8552 (ENS, UPMC, CNRS), 75 - Paris (France); Damour, Th. [Institut des Hautes Etudes Scientifiques, 91 - Bures sur Yvette (France); Darrigol, O. [Centre National de la Recherche Scientifique (CNRS), Groupe Histoire des Sciences Rehseis, 75 - Paris (France); Pocholle, J.P. [Thales Research et Technology France, 91 - Palaiseau (France)

    2005-07-01

    The most important contributions of Einstein involve 5 fields of physics : the existence of quanta (light quanta, stimulated radiation emission and Bose-Einstein condensation), relativity, fluctuations (Brownian motion and thermodynamical fluctuations), the basis of quantum physics and cosmology (cosmological constant and the expansion of the universe). Diverse and renowned physicists have appreciated the development of modern physics from Einstein's ideas to the knowledge of today. This book is a collective book that gathers their work under 7 chapters: 1) 1905, a new beginning; 2) from the Einstein, Podolsky and Rosen's article to quantum information (cryptography and quantum computers); 3) the Bose-Einstein condensation in gases; 4) from stimulated emission to the today's lasers; 5) Brownian motion and the fluctuation-dissipation theory; 6) general relativity; and 7) cosmology. (A.C.)

  8. Beyond Einstein

    Science.gov (United States)

    Hertz, P.

    2003-03-01

    The Structure and Evolution of the Universe (SEU) theme within NASA's Office of Space Science seeks to explore and understand the dynamic transformations of energy in the Universe - the entire web of biological and physical interactions that determine the evolution of our cosmic habitat. This search for understanding will enrich the human spirit and inspire a new generation of explorers, scientists, and engineers. To that end, NASA's strategic planning process has generated a new Roadmap to enable those goals. Called "Beyond Einstein", this Roadmap identifies three science objectives for the SEU theme: (1) Find out what powered the Big Bang; (2) Observe how black holes manipulate space, time, and matter; and (3) Identify the mysterious dark energy pullingthe Universe apart. These objectives can be realized through a combination of large observatories (Constellation-X, LISA), moderate sized, PI-led missions (the Einstein Probes), and a contuinuing program of technology development, research and analysis, and education/public outreach. In this presentation, NASA's proposed Beyond Einstein Program will be described. The full Roadmap is available at http://universe.nasa.gov/.

  9. Einstein unmasked

    Science.gov (United States)

    Foster, Brian

    2008-09-01

    This is a remarkable and, at times, bewilderingly diverse volume. Consisting of 20 essays that represent the proceedings of a conference held in 2005 in Berlin, Germany, during the International Year of Physics, it offers insights into Einstein's influence on a swathe of human activity. In the introduction the distinguished editors make some remarkable claims for the book, calling it "an unique attempt" and saying that "there is no better introduction to...string theory", while the first essay states "Not since Newton's Principia..." Clearly this is a volume that aspires to high standards.

  10. Einsteins dream

    International Nuclear Information System (INIS)

    Parker, B.

    1986-01-01

    This book discusses the following topics: the search for meaning; Einstein's dream; curved space; Einstein and warped space-time and extreme wraping; early unified field theories; star death; beyond the white dwarf; the early universe; the hadron, Lepton, and Radiation eras; the redshift controversy; other universes; the final fate of the universe; the missing mass; bounce; fate of the open universe; the world of particles and fields; Dirac's equation; Yukawa; gauge theory; quantum chromodynamics; supergravity and superstrings; twistors and heaven; and the new Einstein

  11. Einstein's universe

    CERN Document Server

    Calder, Nigel

    1979-01-01

    This brilliantly written book unlocks the astounding implications of Einstein's revolutionary theories on the nature of science, time and motion. It far surpasses any previous explanation of Relativity for laymen.

  12. Celebrating Einstein

    Science.gov (United States)

    Shapiro Key, Joey; Yunes, Nicolas

    2013-04-01

    The Gravity Group at Montana State University (MSU) hosted Celebrating Einstein, a free public arts and multimedia event celebrating Einstein and his ideas in Bozeman, Montana April 2-6, 2013. The products of our efforts are now available to any party interested in hosting a similar event. Celebrating Einstein is a truly interdisciplinary effort including art, film, dance, music, physics, history, and education. Events included a black hole immersive art installation, a series of public talks by physicists, and Einstein lessons in the public schools leading up to a live free public multimedia performance including a professional dance company, a live interview with a renowned physicist, and an original score composed for the MSU student symphony to be performed with an original film produced by the Science and Natural History film program at MSU. This project is funded by the Montana Space Grant Consortium, Montana State University, and the National Science Foundation.

  13. Einstein's error

    International Nuclear Information System (INIS)

    Winterflood, A.H.

    1980-01-01

    In discussing Einstein's Special Relativity theory it is claimed that it violates the principle of relativity itself and that an anomalous sign in the mathematics is found in the factor which transforms one inertial observer's measurements into those of another inertial observer. The apparent source of this error is discussed. Having corrected the error a new theory, called Observational Kinematics, is introduced to replace Einstein's Special Relativity. (U.K.)

  14. Albert Einstein memorial lectures

    CERN Document Server

    Mechoulam, Raphael; The Israel Academy for Sciences and Humanities

    2012-01-01

    This volume consists of a selection of the Albert Einstein Memorial Lectures presented annually at the Israel Academy of Sciences and Humanities. Delivered by eminent scientists and scholars, including Nobel laureates, they cover a broad spectrum of subjects in physics, chemistry, life science, mathematics, historiography and social issues. This distinguished memorial lecture series was inaugurated by the Israel Academy of Sciences and Humanities following an international symposium held in Jerusalem in March 1979 to commemorate the centenary of Albert Einstein's birth. Considering that Einstein's interests, activities and influence were not restricted to theoretical physics but spanned broad fields affecting society and the welfare of humankind, it was felt that these memorial lectures should be addressed to scientists, scholars and erudite laypersons rather than to physicists alone.

  15. Einstein's meanders

    Science.gov (United States)

    Lomnitz, C.

    2007-05-01

    What does Einstein have to do with subduction? Good question. Peaceful Lake Budi, lying at the heart of an Indian reservation in the Deep South of Chile, had subsided by two meters in the 1960 mega-thrust earthquake. This unique South American salt lake was hiding an awful secret: it was actually an oxbow, not a lake. But Einstein had realized in 1926 that meanders are natural freaks. Rivers will not flow uphill, yet - he claimed - they don't flow down the path of steepest descent either. This anomaly was put at the doorstep of a weak Coriolis Force. Thus Einstein problematized the dilemma of the earth sciences. How can a non-force produce margin-parallel compression in a convergent margin where extension is expected? In fact, where does the energy for meander formation come from? Good question . . . Even Wikipedia knows that Coriolis is not a “force” but an “effect”. So is the obliquity of plate convergence in subduction. Where did Einstein err, and where was he a pioneer? Coastal ablation plus alternating subsidence and emergence in giant earthquakes may yield an answer. Einstein, A. (1926). Die Ursache der Maeanderbildung der Flusslaeufe und das sogenannte Baersche Gesetz, Naturwissenschaften, 14, fascicle II.

  16. The Einstein almanac

    CERN Document Server

    Calaprice, Alice

    2005-01-01

    Albert Einstein was an exceptional human being. Perhaps nothing reflects the breadth and scope of his brilliance, his interests, and his influence better than his publications -- more than six hundred scientific papers, books, essays, reviews, and opinion pieces. Einstein began publishing in March 1901 with a scientific work that appeared in the German journal Annalen der Physik when he was twenty-two; the last publication was an editorial in the journal Common Cause which appeared a few months before his death in 1955. In the fifty-four-year interval, his published work ranged widely over relativity theory and quantum physics, nationalism, Judaism, war, peace, and education. Indeed, Einstein's literary output was so abundant that even many of his most informed admirers are not familiar with all of it. The Einstein Almanac takes a look at Einstein's year-by-year output, explaining his three-hundred most important publications and setting them into the context of his life, science, and world history. Concentr...

  17. Einstein's Mirror

    Science.gov (United States)

    Gjurchinovski, Aleksandar; Skeparovski, Aleksandar

    2008-01-01

    Reflection of light from a plane mirror in uniform rectilinear motion is a century-old problem, intimately related to the foundations of special relativity. The problem was first investigated by Einstein in his famous 1905 paper by using the Lorentz transformations to switch from the mirror's rest frame to the frame where the mirror moves at a…

  18. Einstein from 'B' to 'Z'

    CERN Document Server

    Stachel, John

    2002-01-01

    John Stachel, the author of this collection of 37 published and unpublished articles on Albert Einstein, has written about Einstein and his work for over 40 years. Trained as a theoretical physicist specializing in the theory of relativity, he was chosen as the founding editor of The Collected papers of Albert Einstein 25 years ago, and is currently Director of the Boston University Center for Einstein Studies. Based on a detailed study of documentary evidence, much of which was newly discovered in the course of his work, Stachel debunks many of the old (and some new) myths about Einstein and offers novel insight into his life and work. Throughout the volume, a new, more human picture of Einstein is offered to replace the plaster saint of popular legend. In particular, a youthful Einstein emerges from the obscurity that previously shrouded his early years, and much new light is shed on the origins of the special and general theories of relativity. Also discussed in some detail are Einstein's troubled relatio...

  19. Einstein and Austria

    International Nuclear Information System (INIS)

    Broda, E.

    1979-01-01

    This text was written by Engelbert Broda in 1979 and is about Albert Einstein and his relation to Austria. This text is split in different sections which are amongst others: Einstein und Mach; Einstein und Boltzmann; Positivism, Atoms and Relativity; Einstein as an Austrian professor; Einstein’s visits to Austria; Einstein and Viennese friends; Einstein and Friedrich Adler; Einstein and the Austrian mentality; (nowak)

  20. Einstein's Mirror

    Science.gov (United States)

    Gjurchinovski, Aleksandar; Skeparovski, Aleksandar

    2008-10-01

    Reflection of light from a plane mirror in uniform rectilinear motion is a century-old problem, intimately related to the foundations of special relativity.1-4 The problem was first investigated by Einstein in his famous 1905 paper by using the Lorentz transformations to switch from the mirror's rest frame to the frame where the mirror moves at a constant velocity.5 Einstein showed an intriguing fact that the usual law of reflection would not hold in the case of a uniformly moving mirror, that is, the angles of incidence and reflection of the light would not equal each other. Later on, it has been shown that the law of reflection at a moving mirror can be obtained in various alternative ways,6-10 but none of them seems suitable for bringing this interesting subject into the high school classroom.

  1. Albert Einstein

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    In a single year, 1905, Albert Einstein made several dramatic contributions to physics. He deduced the true nature of Brownian motion (doing much to underline the molecular and atomic nature of matter), he demonstrated the particle nature of light in a way which was accessible to experimental investigation (the work for which he received the Nobel prize) and, most dramatically of all, he conceived the special theory of relativity

  2. Albert Einstein Centenary

    CERN Document Server

    Weisskopf, Victor Frederick; CERN. Geneva

    1979-01-01

    A socially engaged scientist by V. F. WEISSKOPF. On the origin of the Einstein-Russell statement on nuclear weapon by H. S. BURHOP. This week, we pay homage to Albert Einstein, the giant of twentieth-century physics born exactly 100 years ago on 14 March 1879 in Ulm, Germany. At the height of his career, Einstein made a whole series of monumental contributions to physics, including the elaborate theories of special and general relativity which revolutionized human thought and marked a major breakthrough in our understanding to the Universe. Along with quantum mechanics, relativity is one of the twin pillars of understanding which allow us here at CERN to study the behaviour of the tiniest components of matter. The development of quantum mechanics took the combined efforts of some of the greatest scientists the world has known, while relativity was developed almost single-handed by Einstein. The centenary of his birth is being commemorated all over the world. Exhibitions and symposia are being organized, books...

  3. Maja Winteler-Einstein

    Indian Academy of Sciences (India)

    Einstein. Articles written in Resonance – Journal of Science Education. Volume 5 Issue 4 April 2000 pp 111-120 Reflections. Albert Einstein: A Biographical Sketch · Maja Winteler-Einstein · More Details Fulltext PDF ...

  4. Sulfogalactosylglycerolipid is involved in human gamete interaction.

    Science.gov (United States)

    Weerachatyanukul, W; Rattanachaiyanont, M; Carmona, E; Furimsky, A; Mai, A; Shoushtarian, A; Sirichotiyakul, S; Ballakier, H; Leader, A; Tanphaichitr, N

    2001-12-01

    Recent results from our laboratory have revealed the role of sulfogalactosylglycerolipid (SGG) in mouse sperm-zona pellucida (ZP) binding. In this report, we demonstrated the presence of SGG in Percoll-gradient centrifuged (PGC) human sperm by high performance thin layer chromatography with orcinol and Azure A staining, specific for glycolipids and sulfolipids, respectively. SGG in human PGC sperm was quantified by its affinity to Azure A to be 12-15 mol% of sperm lipids. Indirect immunofluorescence revealed that SGG existed on both live and aldehyde fixed human sperm in the head region. Pretreatment of human PGC sperm with affinity purified antiSGG Fab markedly inhibited sperm binding to the ZP in a concentration dependent manner, without any changes in the spontaneous acrosome rate or sperm motility parameters. Fluorescently labeled SGG liposomes also bound uniformly to isolated human ZP, while fluorescently labeled galactosylglycerolipid (GG, SGG's parental lipid) or phosphatidylserine (PS, negatively charged like SGG) liposomes did not. All of these results suggested the role of human sperm SGG in ZP binding. Copyright 2001 Wiley-Liss, Inc.

  5. Albert Einstein Centenary

    CERN Document Server

    Amati, Daniele; Weisskopf, Victor Frederick; CERN. Geneva

    1979-01-01

    The scientist and his work by D. AMATI and S. FUBINI. A socially engaged scientist by V. F. WEISSKOPF. This week, we pay homage to Albert Einstein, the giant of twentieth-century physics born exactly 100 years ago on 14 March 1879 in Ulm, Germany. At the height of his career, Einstein made a whole series of monumental contributions to physics, including the elaborate theories of special and general relativity which revolutionized human thought and marked a major breakthrough in our understanding to the Universe. Along with quantum mechanics, relativity is one of the twin pillars of understanding which allow us here at CERN to study the behaviour of the tiniest components of matter. The development of quantum mechanics took the combined efforts of some of the greatest scientists the world has known, while relativity was developed almost single-handed by Einstein. The centenary of his birth is being commemorated all over the world. Exhibitions and symposia are being organized, books published, postage stamps is...

  6. Modeling human learning involved in car driving

    NARCIS (Netherlands)

    Wewerinke, P.H.

    1994-01-01

    In this paper, car driving is considered at the level of human tracking and maneuvering in the context of other traffic. A model analysis revealed the most salient features determining driving performance and safety. Learning car driving is modelled based on a system theoretical approach and based

  7. Conceptual Development of Einstein's Mass-Energy Relationship

    Science.gov (United States)

    Wong, Chee Leong; Yap, Kueh Chin

    2005-01-01

    Einstein's special theory of relativity was published in 1905. It stands as one of the greatest intellectual achievements in the history of human thought. Einstein described the equivalence of mass and energy as "the most important upshot of the special theory of relativity" (Einstein, 1919). In this paper, we will discuss the evolution of the…

  8. Thermodynamics in Einstein's thought

    International Nuclear Information System (INIS)

    Klein, M.J.

    1983-01-01

    The role of the thermodynamical approach in the Einstein's scientific work is analyzed. The Einstein's development of a notion about statistical fluctuations of thermodynamical systems that leads him to discovery of corpuscular-wave dualism is retraced

  9. Einstein's philosophy of physics

    International Nuclear Information System (INIS)

    Seeger, R.J.

    1979-01-01

    Sources of Einstein's philosophical ideas are discussed. Einstein was indebted to Mach and Poincare, and espoused more or less a logical empiricism. He looked upon Nature as real, rational, and understandable, at least to an extent

  10. Einstein. A centenary volume

    International Nuclear Information System (INIS)

    French, A.P.

    1979-01-01

    The subject is divided as follows: part 1, reminiscences (of Einstein and his life, by various authors); part 2, Einstein and his work (includes accounts of special and general relativity, gravitation, the development of quantum physics and concepts of space and time); part 3, Einstein's letters; part 4, Einstein's writings (including accounts of electrodynamics of moving bodies, general relativity, method of theoretical physics and an elementary derivation of the equivalence of mass and energy). (U.K.)

  11. From Einstein to AXAF

    International Nuclear Information System (INIS)

    Tananbaum, H.

    1990-01-01

    The presentations at the 10th Anniversary Einstein Symposium and the articles in this book cover a wide variety of scientific topics describing some of the important advances and discoveries made with the Einstein Observatory. The breadth and depth of science carried out with Einstein has made it essentially impossible to cover fully individual subdisciplines in single review talks and papers. Some of the major Einstein highlights are summarized and the scientific prospects for AXAF are assessed. (author)

  12. The Society's Involvement in the Defense of Human Rights

    Science.gov (United States)

    Gerjuoy, Edward

    2015-04-01

    The history of the Society's involvement in the defense of human rights, a history of which the Society can be proud, will be summarized; the summary will include illustrative specific APS human rights defense actions in illustrative specific cases. As will be emphasized, the aforesaid involvement has been primarily through the activities of the APS Committee on International Freedom of Scientists (CIFS). It is noteworthy-and one of the reasons the Society can be proud-that CIFS is charged with ``monitoring concerns regarding human rights for scientists,'' not solely for physicists, and that CIFS indeed has sought to protect the human rights of nonphysicists.

  13. Albert Einstein's Magic Mountain: An Aarau Education*

    Science.gov (United States)

    Hunziker, Herbert

    2015-03-01

    For economic reasons, the electrotechnical factory J. Einstein & Cie. (co-owned by Albert Einstein's father Hermann) had to be closed in the summer of 1894. While Albert's parents emigrated to Italy to build a new existence, he remained in Munich to complete his studies at the Gymnasium. Left behind, however, he had a difficult time with what he considered the rigid educational practices at the Munich Luitpold-Gymnasium and quit without a diploma. The present article discusses Einstein's richly winding path to the Aargau Cantonal School (Switzerland), especially its history and educational philosophy during the time of his stay in Aarau. There, Einstein met some outstanding teachers, who could serve him as models of scholars and human beings. In spite of Einstein's distinct independence of mind, these personalities may well have had a significant influence on the alignment of his inner compass.

  14. Einstein was right!

    CERN Document Server

    Hess, Karl

    2014-01-01

    All modern books on Einstein emphasize the genius of his relativity theory and the corresponding corrections and extensions of the ancient space-time concept. However, Einstein's opposition to the use of probability in the laws of nature and particularly in the laws of quantum mechanics is criticized and often portrayed as outdated. The author of Einstein Was Right! takes a unique view and shows that Einstein created a ""Trojan horse"" ready to unleash forces against the use of probability as a basis for the laws of nature. Einstein warned that the use of probability would, in the final analys

  15. Einstein solvmanifolds and the pre-Einstein derivation

    OpenAIRE

    Nikolayevsky, Y.

    2008-01-01

    An Einstein nilradical is a nilpotent Lie algebra, which can be the nilradical of a metric Einstein solvable Lie algebra. The classification of Riemannian Einstein solvmanifolds (possibly, of all noncompact homogeneous Einstein spaces) can be reduced to determining, which nilpotent Lie algebras are Einstein nilradicals and to finding, for every Einstein nilradical, its Einstein metric solvable extension. For every nilpotent Lie algebra, we construct an (essentially unique) derivation, the pre...

  16. Einstein's Cosmos (German Title: Einsteins Kosmos)

    Science.gov (United States)

    Duerbeck, Hilmar W.; Dick, Wolfgang R.

    The different contributions of the present volume illuminate the interaction between Einstein and his colleagues when the foundations of modern cosmology were laid: First, the relativistic effects in the solar system, the gravitational redshift in the solar spectrum, and Einstein's relations with Freundlich and Eddington. Second, the cosmological models of Einstein, de Sitter, Friedmann, and Lemaître, which were discussed controversely till the end of the 1920s. Other scientists have also widened or critically questioned Einstein's insight and knowledge: Schwarzschild, Selety, Silberstein, and Mandl, whose life and work is discussed in separate articles. In those days, politics more than ever in history had influenced the lifes of scientists. Therefore, some comments on the ``political cosmos'' that has influenced decisively Einstein's life are also given. A special role in popularizing Einstein's world view was played by Archenhold Observatory in Berlin. A list of Einstein memorial places and a bibliographic list conclude the present book. All papers are written in German, and have English abstracts.

  17. Classification system for reporting events involving human malfunctions

    International Nuclear Information System (INIS)

    Rasmussen, J.; Pedersen, O.M.; Mancini, G.

    1981-01-01

    The report describes a set of categories for reporting industrial incidents and events involving human malfunction. The classification system aims at ensuring information adequate for improvement of human work situations and man-machine interface systems and for attempts to quantify ''human error'' rates. The classification system has a multifacetted non-hierarchical structure and its compatibility with Ispra's ERDS classification is described. The collection of the information in general and for quantification purposes are discussed. 24 categories, 12 of which being human factors-oriented, are listed with their respective subcategories, and comments are given. Underlying models of human data process and their typical malfuntions and of a human decision sequence are described. The work reported is a joint contribution to the CSNI Group of Experts on Human Error Data and Assessment

  18. Einstein and relativity

    International Nuclear Information System (INIS)

    Cullwick, E.G.

    1979-01-01

    Einstein published his Special Theory of Relativity in 1905 and in 1915 his General Theory which predicted the bending of light rays passing near the sun. This prediction was apparently confirmed experimentally in 1919 bringing Einstein popular acclaim. Einstein's work is reviewed and the question of whether he was in fact first in the field is examined with especial reference to the work of Maxwell, Lorentz and Poincare. (U.K.)

  19. Neuromythology of Einstein's brain.

    Science.gov (United States)

    Hines, Terence

    2014-07-01

    The idea that the brain of the great physicist Albert Einstein is different from "average" brains in both cellular structure and external shape is widespread. This belief is based on several studies examining Einstein's brain both histologically and morphologically. This paper reviews these studies and finds them wanting. Their results do not, in fact, provide support for the claim that the structure of Einstein's brain reflects his intellectual abilities. Copyright © 2014 Elsevier Inc. All rights reserved.

  20. Classification system for reporting events involving human malfunctions

    International Nuclear Information System (INIS)

    Rasmussen, J.; Pedersen, O.M.; Mancini, G.; Carnino, A.; Griffon, M.; Gagnolet, P.

    1981-03-01

    The report describes a set of categories for reporting industrial incidents and events involving human malfunction. The classification system aims at ensuring information adequate for improvement of human work situations and man-machine interface systems and for attempts to quantify ''human error'' rates. The classification system has a multifacetted non-hierarchial structure and its compatibility with Ispra's ERDS classification is described. The collection of the information in general and for quantification purposes are discussed. 24 categories, 12 of which being human factors oriented, are listed with their respective subcategories, and comments are given. Underlying models of human data processes and their typical malfunctions and of a human decision sequence are described. (author)

  1. Classification system for reporting events involving human malfunctions

    DEFF Research Database (Denmark)

    Rasmussen, Jens; Pedersen, O.M.; Mancini, G.

    1981-01-01

    The report describes a set of categories for reporting indus-trial incidents and events involving human malfunction. The classification system aims at ensuring information adequate for improvement of human work situations and man-machine interface systems and for attempts to quantify "human error......" rates. The classification system has a multifacetted non-hierarchical struc-ture and its compatibility with Isprals ERDS classification is described. The collection of the information in general and for quantification purposes are discussed. 24 categories, 12 of which being human factors oriented......, are listed with their respective subcategories, and comments are given. Underlying models of human data processes and their typical malfunc-tions and of a human decision sequence are described....

  2. The ultimate quotable Einstein

    CERN Document Server

    2011-01-01

    Here is the definitive new edition of the hugely popular collection of Einstein quotations that has sold tens of thousands of copies worldwide and been translated into twenty-five languages. The Ultimate Quotable Einstein features 400 additional quotes, bringing the total to roughly 1,600 in all. This ultimate edition includes new sections--"On and to Children," "On Race and Prejudice," and "Einstein's Verses: A Small Selection"--as well as a chronology of Einstein's life and accomplishments, Freeman Dyson's authoritative foreword, and new commentary by Alice Calaprice.

  3. Einstein and Prague

    International Nuclear Information System (INIS)

    Bicak, J.

    1979-01-01

    A commemorative publication is submitted issued on the occasion of Albert Einstein's centenary remembering Einstein's sojourn and work in Prague. In addition to the article Ueber den Einfluss der Schwerkraft auf die Ausbreitung des Lichtes the publications contains the author's preface to the Czech edition of his Theory, the list of studies written by Einstein while in Prague, an assay on the great physicist's life and work, and extracts from the memoires of Philipp Frank published under the title Einstein, His Life and Times. (L.O.)

  4. Quantifying Engagement: Measuring Player Involvement in Human-Avatar Interactions

    Science.gov (United States)

    Norris, Anne E.; Weger, Harry; Bullinger, Cory; Bowers, Alyssa

    2014-01-01

    This research investigated the merits of using an established system for rating behavioral cues of involvement in human dyadic interactions (i.e., face-to-face conversation) to measure involvement in human-avatar interactions. Gameplay audio-video and self-report data from a Feasibility Trial and Free Choice study of an effective peer resistance skill building simulation game (DRAMA-RAMA™) were used to evaluate reliability and validity of the rating system when applied to human-avatar interactions. The Free Choice study used a revised game prototype that was altered to be more engaging. Both studies involved girls enrolled in a public middle school in Central Florida that served a predominately Hispanic (greater than 80%), low-income student population. Audio-video data were coded by two raters, trained in the rating system. Self-report data were generated using measures of perceived realism, predictability and flow administered immediately after game play. Hypotheses for reliability and validity were supported: Reliability values mirrored those found in the human dyadic interaction literature. Validity was supported by factor analysis, significantly higher levels of involvement in Free Choice as compared to Feasibility Trial players, and correlations between involvement dimension sub scores and self-report measures. Results have implications for the science of both skill-training intervention research and game design. PMID:24748718

  5. Revisiting Einstein's brain in Brain Awareness Week.

    Science.gov (United States)

    Chen, Hao; Chen, Su; Zeng, Lidan; Zhou, Lin; Hou, Shengtao

    2014-10-01

    Albert Einstein's brain has long been an object of fascination to both neuroscience specialists and the general public. However, without records of advanced neuro-imaging of his brain, conclusions regarding Einstein's extraordinary cognitive capabilities can only be drawn based on the unique external features of his brain and through comparison of the external features with those of other human brain samples. The recent discovery of 14 previously unpublished photographs of Einstein's brain taken at unconventional angles by Dr. Thomas Stoltz Harvey, the pathologist, ignited a renewed frenzy about clues to explain Einstein's genius. Dr. Dean Falk and her colleagues, in their landmark paper published in Brain (2013; 136:1304-1327), described in such details about the unusual features of Einstein's brain, which shed new light on Einstein's intelligence. In this article, we ask what are the unique structures of his brain? What can we learn from this new information? Can we really explain his extraordinary cognitive capabilities based on these unique brain structures? We conclude that studying the brain of a remarkable person like Albert Einstein indeed provides us a better example to comprehensively appreciate the relationship between brain structures and advanced cognitive functions. However, caution must be exercised so as not to over-interpret his intelligence solely based on the understanding of the surface structures of his brain.

  6. Ethical issues in neonatal research involving human subjects.

    Science.gov (United States)

    Fleischman, Alan R

    2016-06-01

    Research involving critically ill neonates creates many ethical challenges. Neonatal clinical research has always been hard to perform, is very expensive, and may generate some unique ethical concerns. This article describes some examples of historical and modern controversies in neonatal research, discusses the justification for research involving such vulnerable and fragile patients, clarifies current federal regulations that govern research involving neonates, and suggests ways that clinical investigators can develop and implement ethically grounded human subjects research. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Committees for Ethics in Research involving human subjects.

    Science.gov (United States)

    Hossne, William Saad; Vieira, Sonia; De Freitas, Corina Bontempo Duca

    2008-01-01

    In Brazil since October 1996 there have been guidelines for research involving human subjects. Now human subjects know when their treatment is part of research. Deceit is no longer tolerated. But is not enough to say we offer an explanation to the potential subject and we offer a choice before he or she is confronted with an informed consent form. As in all professional activity, scientific investigation needs social controls. In Brazil, the ultimate responsibility of an investigation lies on the investigator, but in every institution where research is carried out there is a Committee for Ethics in Research. All Committees are subordinated to the National Commission of Ethics in Research, which is submitted to the Brazilian Institute of Health. During 2005 around 17,000 protocols involving 700,000 human subjects were revised by 475 Committees distributed all over the country. Approximately 7,000 people are now working in these Committees.

  8. Einstein Up in Smoke

    Science.gov (United States)

    Lisle, John

    2016-01-01

    Albert Einstein's biographers have not explained why he developed the abdominal aortic aneurysm that led to his death. Early conjectures proposed that it was caused by syphilis, without accurate evidence. The present article gives evidence to the contrary, and argues that the principal cause of Einstein's death was smoking.

  9. Albert Einsteins Wonderjaar

    NARCIS (Netherlands)

    Dieks, D.G.B.J.

    In het jaar 1905 publiceerde Albert Einstein een reeks artikelen die een omwenteling voor de wetenschap betekende. En toch bleef Einstein een kind van zijn tijd, van een eeuw die in het teken stond van dynamo’s, raderen en stoommachines.

  10. Bose-Einstein correlations

    International Nuclear Information System (INIS)

    Zalewski, Kacper

    2000-01-01

    The effect of Bose-Einstein correlations on multiplicity distributions of identical pions is discussed. It is found that these correlations affect significantly the observed multiplicity distributions, but Einstein's condensation is unlikely to be achieved, unless 'cold spots', i.e. regions, where groups of pions with very small relative momenta are produced, occur in high energy heavy-ion collisions

  11. Einstein (1879-1955)

    International Nuclear Information System (INIS)

    Anon.

    1980-01-01

    In the first part of this book a historical review of Einstein life and works are presented. In the second part papers about different aspects of quantum mechanics are given. The third part is devoted to a round table on Einstein, Podolski and Rosen paradox [fr

  12. Einstein A to Z

    CERN Document Server

    Fox, Karen C

    2004-01-01

    Einstein was the twentieth century's most celebrated scientist - a man who developed the theory of relativity, revolutionised physics and became an iconic genius in the popular imagination. Essays range from the reasonably scientific including the theory of relativity, to the odd and engaging, such as Einstein's brain, his favourite jokes and films.

  13. When Art Meets Einstein

    Science.gov (United States)

    Science Scope, 2006

    2006-01-01

    This article deals with a pale blue sculpture entitled "A New World View", as an homage to the most famous scientist in modern history, Albert Einstein. It has 32 bas-relief squares composed of glass and steel that represent one aspect of the life and legacy of Albert Einstein. Images of children's faces peer out from behind the glass squares,…

  14. Vortex sorter for Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Whyte, Graeme; Veitch, John; Courtial, Johannes; Oehberg, Patrik

    2004-01-01

    We have designed interferometers that sort Bose-Einstein condensates into their vortex components. The Bose-Einstein condensates in the two arms of the interferometer are rotated with respect to each other through fixed angles; different vortex components then exit the interferometer in different directions. The method we use to rotate the Bose-Einstein condensates involves asymmetric phase imprinting and is itself new. We have modeled rotation through fixed angles and sorting into vortex components with even and odd values of the topological charge of two-dimensional Bose-Einstein condensates in a number of states (pure or superposition vortex states for different values of the scattering length). Our scheme may have applications for quantum information processing

  15. Albert Einstein a biography

    CERN Document Server

    Fölsing, Albrecht

    1997-01-01

    Albert Einstein's achievements are not just milestones in the history of science; decades ago they became an integral part of the twentieth-century world in which we live. Like no other modern physicist he altered and expanded our understanding of nature. Like few other scholars, he stood fully in the public eye. In a world changing with dramatic rapidity, he embodied the role of the scientist by personal example. Albrecht Folsing, relying on previously unknown sources and letters, brings Einstein's "genius" into focus. Whereas former biographies, written in the tradition of the history of science, seem to describe a heroic Einstein who fell to earth from heaven, Folsing attempts to reconstruct Einstein's thought in the context of the state of research at the turn of the century. Thus, perhaps for the first time, Einstein's surroundings come to light.

  16. Einstein and Planck

    Science.gov (United States)

    Heilbron, John

    2005-03-01

    As an editor of the Annalen der Physik, Max Planck published Einstein's early papers on thermodynamics and on special relativity, which Planck probably was the first major physicist to appreciate. They respected one another not only as physicists but also, for their inspired creation of world pictures, as artists. Planck helped to establish Einstein in a sinecure at the center of German physics, Berlin. Despite their differences in scientific style, social life, politics, and religion, they became fast friends. Their mutual admiration survived World War I, during which Einstein advocated pacifism and Planck signed the infamous Manifesto of the 93 Intellectuals supporting the German invasion of Belgium. It also survived the Weimar Republic, which Einstein favored and Planck disliked. Physics drew them together, as both opposed the Copenhagen Interpretation; so did common decency, as Planck helped to protect Einstein from anti-semitic attacks. Their friendship did not survive the Nazis. As a standing secretary of the Berlin Academy, Planck had to advise Einstein to resign from it before his colleagues, outraged at his criticism of the new Germany from the safety of California, expelled him. Einstein never forgave his old friend and former fellow artist for not protesting publicly against his expulsion and denigration, and other enormities of National Socialism. .

  17. Regulating hematology/oncology research involving human participants.

    Science.gov (United States)

    Kapp, Marshall B

    2002-12-01

    The conduct of hematology/oncology research, particularly clinical trials involving human participants, is an extensively regulated enterprise. Professionals in the specialty of hematology/oncology have important stakes in the success of biomedical research endeavors. Knowledge about and compliance strategies regarding the pertinent regulatory parameters are essential for avoiding negative legal repercussions for involved professionals. At the same time, there is a need to be aware of and actively resist the danger that strong [legal] protectionism might inadvertently result in undermining physician investigators' sense of personal moral responsibility in the conduct of human experiments. For all the limitations of that virtue in the protection of human subjects, it is surely not one that we would want medical scientists to be without [47]. Members of the potential participant pool, financial sponsors, and the general public must be convinced that everyone involved in the research enterprise is committed to operating within acceptable legal and ethical boundaries if the atmosphere of confidence and trust that is indispensable to the continued process and progress of investigation aimed at extending and improving quality of life for all of us in the future is to continue and flourish [48].

  18. Einstein: A Historical Perspective

    Science.gov (United States)

    Kormos-Buchwald, Diana

    2015-04-01

    In late 1915, Albert Einstein (1879-1955) completed as series of papers on a generalized theory of gravitation that were to constitute a major conceptual change in the history of modern physics and the crowning achievement of his scientific career. But this accomplishment came after a decade of intense intellectual struggle and was received with muted enthusiasm. Einstein's previously unpublished writings and massive correspondence, edited by the Einstein Papers Project, provide vivid insights into the historical, personal, and scientific context of the formulation, completion, and reception of GR during the first decades of the 20th century.

  19. Einstein's statistical mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Baracca, A; Rechtman S, R

    1985-08-01

    The foundation of equilibrium classical statistical mechanics were laid down in 1902 independently by Gibbs and Einstein. The latter's contribution, developed in three papers published between 1902 and 1904, is usually forgotten and when not, rapidly dismissed as equivalent to Gibb's. We review in detail Einstein's ideas on the foundations of statistical mechanics and show that they constitute the beginning of a research program that led Einstein to quantum theory. We also show how these ideas may be used as a starting point for an introductory course on the subject.

  20. Einstein's statistical mechanics

    International Nuclear Information System (INIS)

    Baracca, A.; Rechtman S, R.

    1985-01-01

    The foundation of equilibrium classical statistical mechanics were laid down in 1902 independently by Gibbs and Einstein. The latter's contribution, developed in three papers published between 1902 and 1904, is usually forgotten and when not, rapidly dismissed as equivalent to Gibb's. We review in detail Einstein's ideas on the foundations of statistical mechanics and show that they constitute the beginning of a research program that led Einstein to quantum theory. We also show how these ideas may be used as a starting point for an introductory course on the subject. (author)

  1. Einstein before Israel Zionist icon or iconoclast?

    CERN Document Server

    Rosenkranz, Ze’ev

    2011-01-01

    Albert Einstein was initially skeptical and even disdainful of the Zionist movement, yet he affiliated himself with this controversial political ideology and today is widely seen as an outspoken advocate for a modern Jewish homeland in Palestine. What enticed this renowned scientist and humanitarian, who repeatedly condemned nationalism of all forms, to radically change his views? Was he in fact a Zionist? Einstein Before Israel traces Einstein's involvement with Zionism from his initial contacts with the movement at the end of World War I to his emigration from Germany in 1933 in the wake of Hitler's rise to power. Drawing on a wealth of rare archival evidence--much of it never before published--this book offers the most nuanced picture yet of Einstein's complex and sometimes stormy relationship with Jewish nationalism. Ze'ev Rosenkranz sheds new light on Einstein's encounters with prominent Zionist leaders, and reveals exactly what Einstein did and didn't like about Zionist beliefs, objectives, and methods...

  2. The practical Einstein experiments, patents, inventions

    CERN Document Server

    Illy, József

    2012-01-01

    Albert Einstein may be best known as the wire-haired whacky physicist who gave us the theory of relativity, but that's just one facet of this genius' contribution to human knowledge and modern science. As Jozsef Illy expertly shows in this book, Einstein had an eminently practical side as well. As a youth, Einstein was an inveterate tinkerer in the electrical supply factory his father and uncle owned and operated. His first paid job was as a patent examiner. Later in life, Einstein contributed to many inventions, including refrigerators, microphones, and instruments for aviation. In published papers, Einstein often provided ways to test his theories and fundamental problems of the scientific community of his times. He delved deeply into a variety of technological innovations, most notably the gyrocompass, and consulted for industry in patent cases and on other legal matters. Einstein also provided explanations for common and mundane phenomena, such as the meandering of rivers. In these and other hands-on exam...

  3. An Einstein encyclopedia

    CERN Document Server

    Calaprice, Alice; Schulmann, Robert

    2015-01-01

    This is the single most complete guide to Albert Einstein’s life and work for students, researchers, and browsers alike. Written by three leading Einstein scholars who draw on their combined wealth of expertise gained during their work on the Collected Papers of Albert Einstein, this authoritative and accessible reference features more than one hundred entries and is divided into three parts covering the personal, scientific, and public spheres of Einstein’s life. An Einstein Encyclopedia contains entries on Einstein’s birth and death, family and romantic relationships, honors and awards, educational institutions where he studied and worked, citizenships and immigration to America, hobbies and travels, plus the people he befriended and the history of his archives and the Einstein Papers Project. Entries on Einstein’s scientific theories provide useful background and context, along with details about his assistants, collaborators, and rivals, as well as physics concepts related to his work. Coverage o...

  4. Once upon Einstein

    CERN Document Server

    Damour, Thibault

    2006-01-01

    It is well known that Einstein founded twentieth-century physics with his work on relativity and quanta, but what do we really know about these ground breaking ideas? How were they discovered? What should we retain today from the conceptual upheavals he initiated? Through a selection of concrete scenes taken from Einstein's life, the author offers a view into the formation of his theories, as well as reminders of the day-to-day applications of his ideas. Simultaneously the reader is lead through a reflection on their philosophical impact: How should we think of time according to the theory of relativity, which removes any meaningful "now" and shows that twins can have different ages? How should we think of reality when quantum theory predicts that spatially separated objects nevertheless remain connected through Einstein's notion of "entanglement," which has recently been verified through scientific observation? This book puts readers in Einstein's place, allowing them to share some of those particular moment...

  5. Herwig Schopper Einstein's Legacy

    CERN Multimedia

    Schneegans, Susan

    2005-01-01

    "Last June, the United Nations declared 2005 the International Year of Physics and invited UNESCO to take the lead in celebrating the hundreth anniversary of Albert Einstein's legandary articles on relativisty, quantum theory and Brownian motion" (3 pages)

  6. Einstein and cosmology

    International Nuclear Information System (INIS)

    Gekman, O.

    1982-01-01

    The brief essay of the development of the main ideas of relativistic cosmology is presented. The Einstein's cosmological work about the Universe - ''Cosmological considerations in connection with the general relativity theory'' - gave the basis to all further treatments in this field. In 1922 A. Friedman's work appeared, in which the first expanding Universe model was proposed as a solution of the Einstein field equations. The model was spherically closed, but its curvature radius was a function of time. About 1955 the searches for anisotropic homogeneous solutions to Einstein field equation began. It turned out that isotropic cosmological models are unstable in general. The predominant part of them transform to anisotropic at insignificant breaking of isotropy. The discovery of isotropic background cosmic radiation in 1965, along with the Hubble low of the Universe expansion, served as the direct confirmation of cosmology based on the Einstein theory

  7. Contingency learning in human fear conditioning involves the ventral striatum.

    Science.gov (United States)

    Klucken, Tim; Tabbert, Katharina; Schweckendiek, Jan; Merz, Christian Josef; Kagerer, Sabine; Vaitl, Dieter; Stark, Rudolf

    2009-11-01

    The ability to detect and learn contingencies between fearful stimuli and their predictive cues is an important capacity to cope with the environment. Contingency awareness refers to the ability to verbalize the relationships between conditioned and unconditioned stimuli. Although there is a heated debate about the influence of contingency awareness on conditioned fear responses, neural correlates behind the formation process of contingency awareness have gained only little attention in human fear conditioning. Recent animal studies indicate that the ventral striatum (VS) could be involved in this process, but in human studies the VS is mostly associated with positive emotions. To examine this question, we reanalyzed four recently published classical fear conditioning studies (n = 117) with respect to the VS at three distinct levels of contingency awareness: subjects, who did not learn the contingencies (unaware), subjects, who learned the contingencies during the experiment (learned aware) and subjects, who were informed about the contingencies in advance (instructed aware). The results showed significantly increased activations in the left and right VS in learned aware compared to unaware subjects. Interestingly, this activation pattern was only found in learned but not in instructed aware subjects. We assume that the VS is not involved when contingency awareness does not develop during conditioning or when contingency awareness is unambiguously induced already prior to conditioning. VS involvement seems to be important for the transition from a contingency unaware to a contingency aware state. Implications for fear conditioning models as well as for the contingency awareness debate are discussed.

  8. Conformal Einstein spaces

    International Nuclear Information System (INIS)

    Kozameh, C.N.; Newman, E.T.; Tod, K.P.

    1985-01-01

    Conformal transformations in four-dimensional. In particular, a new set of two necessary and sufficient conditions for a space to be conformal to an Einstein space is presented. The first condition defines the class of spaces conformal to C spaces, whereas the last one (the vanishing of the Bach tensor) gives the particular subclass of C spaces which are conformally related to Einstein spaces. (author)

  9. Confirmation of RAX gene involvement in human anophthalmia.

    Science.gov (United States)

    Lequeux, L; Rio, M; Vigouroux, A; Titeux, M; Etchevers, H; Malecaze, F; Chassaing, N; Calvas, P

    2008-10-01

    Microphthalmia and anophthalmia are at the severe end of the spectrum of abnormalities in ocular development. Mutations in several genes have been involved in syndromic and non-syndromic anophthalmia. Previously, RAX recessive mutations were implicated in a single patient with right anophthalmia, left microphthalmia and sclerocornea. In this study, we report the findings of novel compound heterozygous RAX mutations in a child with bilateral anophthalmia. Both mutations are located in exon 3. c.664delT is a frameshifting deletion predicted to introduce a premature stop codon (p.Ser222ArgfsX62), and c.909C>G is a nonsense mutation with similar consequences (p.Tyr303X). This is the second report of a patient with anophthalmia caused by RAX mutations. These findings confirm that RAX plays a major role in the early stages of eye development and is involved in human anophthalmia.

  10. EPR before EPR: A 1930 Einstein-Bohr thought Experiment Revisited

    Science.gov (United States)

    Nikolic, Hrvoje

    2012-01-01

    In 1930, Einstein argued against the consistency of the time-energy uncertainty relation by discussing a thought experiment involving a measurement of the mass of the box which emitted a photon. Bohr seemingly prevailed over Einstein by arguing that Einstein's own general theory of relativity saves the consistency of quantum mechanics. We revisit…

  11. Some Einstein spaces and their global properties

    International Nuclear Information System (INIS)

    Siklos, S.T.C.

    1981-01-01

    The global structure of a class of Einstein spaces is investigated. These spaces have algebraically special Weyl tensors and contain homogeneous hypersurfaces. It is found that they display simple examples of a variety of interesting configuration involving horizons and singularities. (author)

  12. Conversations With Albert Einstein. II

    Science.gov (United States)

    Shankland, R. S.

    1973-01-01

    Discusses Einstein's views on the role of Michelson-Morley, Fizeau, and Miller experiments in the development of relativity and his attitude toward the theories of new quantum mechanics. Indicates that Einstein's opposition to quantum mechanics is beyond dispute. (CC)

  13. Einstein's essays in science

    CERN Document Server

    Einstein, Albert

    2009-01-01

    His name is synonymous with ""genius,"" but these essays by the renowned physicist and scholar are accessible to any reader. In addition to outlining the core of relativity theory in everyday language, Albert Einstein presents fascinating discussions of other scientific fields to which he made significant contributions. The Nobel Laureate also profiles some of history's most influential physicists, upon whose studies his own work was based.Assembled during Einstein's lifetime from his speeches and essays, this book marks the first presentation to the wider world of the scientist's accomplishme

  14. Einstein, Kant, and Taoism

    OpenAIRE

    Kim, Y. S.

    2006-01-01

    It is said that Einstein's conceptual base for the theory of relativity was the philosophy formulated by Immanuel Kant. Then, is it possible to see how Kant played a role in Einstein's thinking without reading Kant's books? This question arises because it is not possible for physicists to read Kant's writings. Yes, it is possible if we use the method of physics. It is known also that Kant's mode of thinking was profoundly affected by the geography of Koenigsberg where he spent eighty years of...

  15. Sky surveys with Einstein

    International Nuclear Information System (INIS)

    Gioia, I.M.

    1990-01-01

    Since the early times after the launch of the Einstein Observatory, systematic studies of serendipitous Einstein x-ray sources have been carried out by several observers with interests in both galactic and extragalactic astronomy. The majority of these studies were not surveys in the strict sense of the word: in several cases no analyses requiring flux completeness were performed. However, these systematic searches for sources added much to our knowledge of the behaviour in the X-ray domain of the different classes of astronomical objects and in many instances led to the study of their properties at different wavebands. (author)

  16. Einstein and modern cosmology

    International Nuclear Information System (INIS)

    Stabell, R.

    1979-01-01

    Einstein applied his gravitation theory to a universe model with positively curved space in 1917. In order to maintain a static universe he introduced the cosmological constant, which in the light of later nonstatic universe models, he described as his life's greatest mistake. The best known such model is the Einstein-de Sitter model, which is here discussed in some detail. The 'big bang' theory is also discussed leading to the cosmic background radiation. The early phase of the 'big bang' cosmology, the first ten seconds, and the first minutes are discussed, leading to the transparent stage. (JIW)

  17. Ceremony marking Einstein Year

    CERN Multimedia

    2005-01-01

    Sunday 13th November at 10:00amat Geneva's St. Peter's Cathedral To mark Einstein Year and the importance of the intercultural dialogue of which it forms a part, a religious service will take place on Sunday 13 November at 10 a.m. in St. Peter's Cathedral, to which CERN members and colleagues are warmly welcomed. Pastor Henry Babel, senior minister at the Cathedral, will speak on the theme: 'God in Einstein's Universe'. Diether Blechschmidt will convey a message on behalf of the scientific community.

  18. Human cortical areas involved in perception of surface glossiness.

    Science.gov (United States)

    Wada, Atsushi; Sakano, Yuichi; Ando, Hiroshi

    2014-09-01

    Glossiness is the visual appearance of an object's surface as defined by its surface reflectance properties. Despite its ecological importance, little is known about the neural substrates underlying its perception. In this study, we performed the first human neuroimaging experiments that directly investigated where the processing of glossiness resides in the visual cortex. First, we investigated the cortical regions that were more activated by observing high glossiness compared with low glossiness, where the effects of simple luminance and luminance contrast were dissociated by controlling the illumination conditions (Experiment 1). As cortical regions that may be related to the processing of glossiness, V2, V3, hV4, VO-1, VO-2, collateral sulcus (CoS), LO-1, and V3A/B were identified, which also showed significant correlation with the perceived level of glossiness. This result is consistent with the recent monkey studies that identified selective neural response to glossiness in the ventral visual pathway, except for V3A/B in the dorsal visual pathway, whose involvement in the processing of glossiness could be specific to the human visual system. Second, we investigated the cortical regions that were modulated by selective attention to glossiness (Experiment 2). The visual areas that showed higher activation to attention to glossiness than that to either form or orientation were identified as right hV4, right VO-2, and right V3A/B, which were commonly identified in Experiment 1. The results indicate that these commonly identified visual areas in the human visual cortex may play important roles in glossiness perception. Copyright © 2014. Published by Elsevier Inc.

  19. Involvement of the kynurenine pathway in human glioma pathophysiology.

    Directory of Open Access Journals (Sweden)

    Seray Adams

    Full Text Available The kynurenine pathway (KP is the principal route of L-tryptophan (TRP catabolism leading to the production of kynurenine (KYN, the neuroprotectants, kynurenic acid (KYNA and picolinic acid (PIC, the excitotoxin, quinolinic acid (QUIN and the essential pyridine nucleotide, nicotinamide adenine dinucleotide (NAD(+. The enzymes indoleamine 2,3-dioxygenase-1 (IDO-1, indoleamine 2,3-dioxygenase-2 (IDO-2 and tryptophan 2,3-dioxygenase (TDO-2 initiate the first step of the KP. IDO-1 and TDO-2 induction in tumors are crucial mechanisms implicated to play pivotal roles in suppressing anti-tumor immunity. Here, we report the first comprehensive characterisation of the KP in 1 cultured human glioma cells and 2 plasma from patients with glioblastoma (GBM. Our data revealed that interferon-gamma (IFN-γ stimulation significantly potentiated the expression of the KP enzymes, IDO-1 IDO-2, kynureninase (KYNU, kynurenine hydroxylase (KMO and significantly down-regulated 2-amino-3-carboxymuconate semialdehyde decarboxylase (ACMSD and kynurenine aminotransferase-I (KAT-I expression in cultured human glioma cells. This significantly increased KP activity but significantly lowered the KYNA/KYN neuroprotective ratio in human cultured glioma cells. KP activation (KYN/TRP was significantly higher, whereas the concentrations of the neuroreactive KP metabolites TRP, KYNA, QUIN and PIC and the KYNA/KYN ratio were significantly lower in GBM patient plasma (n = 18 compared to controls. These results provide further evidence for the involvement of the KP in glioma pathophysiology and highlight a potential role of KP products as novel and highly attractive therapeutic targets to evaluate for the treatment of brain tumors, aimed at restoring anti-tumor immunity and reducing the capacity for malignant cells to produce NAD(+, which is necessary for energy production and DNA repair.

  20. Trends in research involving human beings in Brazil

    Directory of Open Access Journals (Sweden)

    Ricardo Eccard da Silva

    2015-02-01

    Full Text Available Developing countries have experienced a dramatic increase in the number of clinical studies in the last decades. The aim of this study was to describe 1 the number of clinical trials submitted to the Brazilian Health Surveillance Agency (Agência Nacional de Vigilância Sanitária, Anvisa from 2007 to 2012 and the number of human-subject research projects approved by research ethics committees (RECs and the National Research Ethics Committee (Comissão Nacional de Ética em Pesquisa, CONEP in Brazil from 2007 to 2011 and 2 the diseases most frequently studied in Brazilian states in clinical trials approved in the country from 2009 to 2012, based on information from an Anvisa databank. Two databases were used: 1 the National Information System on Research Ethics Involving Human Beings (Sistema Nacional de Informação Sobre Ética em Pesquisa envolvendo Seres Humanos, SISNEP and 2 Anvisa's Clinical Research Control System (Sistema de Controle de Pesquisa Clínica, SCPC. Data from the SCPC indicated an increase of 32.7% in the number of clinical trials submitted to Anvisa, and data from the SISNEP showed an increase of 69.9% in those approved by RECs and CONEP (from 18 160 in 2007 to 30 860 in 2011. Type 2 diabetes (26.0% and breast cancer (20.5%-related to the main causes of mortality in Brazil-were the two most frequently studied diseases. The so-called “neglected diseases,” such as dengue fever, were among the least studied diseases in approved clinical trials, despite their significant impact on social, economic, and health indicators in Brazil. Overall, the data indicated 1 a clear trend toward more research involving human beings in Brazil, 2 good correspondence between diseases most studied in clinical trials approved by Anvisa and the main causes of death in Brazil, and 3 a low level of attention to neglected diseases, an issue that should be considered in setting future research priorities, given their socioeconomic and health effects.

  1. Holonomy of Einstein Lorentzian manifolds

    International Nuclear Information System (INIS)

    Galaev, Anton S

    2010-01-01

    The classification of all possible holonomy algebras of Einstein and vacuum Einstein Lorentzian manifolds is obtained. It is shown that each such algebra appears as the holonomy algebra of an Einstein (resp. vacuum Einstein) Lorentzian manifold; the direct constructions are given. Also the holonomy algebras of totally Ricci-isotropic Lorentzian manifolds are classified. The classification of the holonomy algebras of Lorentzian manifolds is reviewed and a complete description of the spaces of curvature tensors for these holonomies is given.

  2. Mileva Maric Einstein vivre avec Albert Einstein

    CERN Document Server

    Milentijevic, Radmila

    2013-01-01

    Radmila Milentijevic n’est pas la première à écrire sur les relations entre le génial Albert Einstein et sa première épouse et précieuse collaboratrice durant ses années de recherches, la scientifique serbe Mileva Maric. Mais c’est la première fois qu’un ouvrage traite de cette idylle, puis de ce drame familial qui a duré près de cinquante années, sous une forme quasiment poétique, si rare dans l’historiographie scientifique.Professeur émérite d’histoire à l’université de New York, l’auteur propose ici une monographie riche et vivante, dévoilant une face cachée d’Albert Einstein, et faisant de sa compagne une figure historique de premier plan en même temps qu’un personnage romanesque dont le destin tragique ne laissera aucun lecteur indifférent.

  3. Einstein was right!

    CERN Multimedia

    2003-01-01

    For the first time scientists have succeeded in measuring the speed of gravity. They took advantage of a rare alignment of Jupiter against a far-off quasar to measure the fundamental constant described by Albert Einstein in his general theory of relativity (2 pages).

  4. Test of Einstein locality

    International Nuclear Information System (INIS)

    Roos, Matts

    1980-11-01

    Einstein locality imples that spacelike separated coherent quantum systems do not interfere, and that all interferences must propagate with at most the speed of light. It then follows that the reaction e + e - →K 0 antiK 0 must yield some Ksub(s)Ksuu(s) decays in apparent violation of P and C conservation. (author)

  5. 2011 Einstein Fellows Chosen

    Science.gov (United States)

    2011-03-01

    ASA has announced the selection of the 2011 Einstein Fellows who will conduct research related to NASA's Physics of the Cosmos program, which aims to expand our knowledge of the origin, evolution, and fate of the Universe. The Einstein Fellowship provides support to the awardees for three years, and the Fellows may pursue their research at a host university or research center of their choosing in the United States. The new Fellows will begin their programs in the fall of 2011. The new Einstein Fellows and their host institutions are listed below: * Akos Bogdan (Smithsonian Astrophysical Observatory, Cambridge, Mass.) * Samuel Gralla (University of Maryland, College Park, Md.) * Philip Hopkins (University of California at Berkeley) * Matthew Kunz (Princeton University, Princeton, N.J.) * Laura Lopez (Massachusetts Institute of Technology, Cambridge, Mass.) * Amy Reines (National Radio Astronomy Observatory, Charlottesville, Virg.) * Rubens Reis (University of Michigan, Ann Arbor) * Ken Shen (Lawrence Berkeley National Laboratory, Berkeley, Calif.) * Jennifer Siegal-Gaskins (California Institute of Technology, Pasadena) * Lorenzo Sironi (Harvard University, Cambridge, Mass.) NASA has two other astrophysics theme-based fellowship programs: the Sagan Fellowship Program, which supports research into exoplanet exploration, and the Hubble Fellowship Program, which supports research into cosmic origins. More information on the Einstein Fellowships can be found at: http://cxc.harvard.edu/fellows/

  6. Bose-Einstein Condensation

    Indian Academy of Sciences (India)

    absolute zero. These ideas had ... Everybody is talking about Bose-Einstein condensation. This discovery ... needed if we want to find the probability distribution of the x- ... Boltzmann took two approaches to the problem, both of them deep and ...

  7. From Newton to Einstein.

    Science.gov (United States)

    Ryder, L. H.

    1987-01-01

    Discusses the history of scientific thought in terms of the theories of inertia and absolute space, relativity and gravitation. Describes how Sir Isaac Newton used the work of earlier scholars in his theories and how Albert Einstein used Newton's theories in his. (CW)

  8. The Light of Einstein

    NARCIS (Netherlands)

    Atkinson, David

    2005-01-01

    The Michelson-Morley experiment suggests the hypothesis that the two-way speed of light is constant,and this is consistent with a more general in variance than that of Lorentz. On adding the requirement that physical laws have the same form in all inertial frames, as Einstein did, the transformation

  9. Examining the Enigmatic Einstein

    Science.gov (United States)

    Khoon, Koh Aik

    2007-01-01

    Albert Einstein is the icon of scientific genius. His is one the most recognizable faces in the history of mankind. This paper takes a cursory look at the man who is commonly perceived to be the epitome of eccentricity. We manage to sum up his salient traits which are associated with his name. The traits are based on anecdotal evidence. This…

  10. Once Upon Einstein

    Energy Technology Data Exchange (ETDEWEB)

    Giannetto, E [Dipartimento di Fisica ' A Volta' , via A Bassi 6, I-27100 Pavia (Italy)

    2007-07-20

    Thibault Damour is a theoretical physicist, and a member of the French Academy of Sciences. This book is the translation, by Eric Novak, of the original French Si Einstein m'etait conte (Le Cherche Midi, 2005). It is neither a book of theoretical physics nor a biography of Einstein. It is not a book of history nor philosophy of science. In Damour's words it was written to encourage the reader to share with Einstein 'those times when he understood some part of the hidden order of the universe'. It is a relatively short book, written in a very fluent style, but it deals with all the major problems and achievements of Einstein's works. Starting from special relativity, it continues with general relativity, quantum theories, unified field theory and a brief overview of the actual research related to Einstein's legacy. It is essentially a popular science book with some related exploration in history and philosophy to interpret physical theories. The most important problem discussed by Damour is the nature of time. On this subject, there is a very interesting short paragraph (pp 33--35) dedicated to the reception of the relativity idea by the great writer Marcel Proust and its counterpart within A la Recherche du Temps Perdu. A correct discussion of the implications of a relativistic time should imply the distinction of the different possible interpretations of this concept. Damour seems to conclude that only one interpretation is possible: 'time does not exist', flowing of time is an illusion. One has to know that Einstein's ideas on time were related to Spinoza's perspective of a knowledge sub specie aeternitatis. However, other interpretations are possible and are related to the idea of time as an actuality. Damour speaks about the controversy between Einstein and Bergson, but Bergson is considered as a philosopher who did not understand relativity. This philosophical problem of relativistic time is indeed related to a

  11. Once Upon Einstein

    International Nuclear Information System (INIS)

    Giannetto, E

    2007-01-01

    Thibault Damour is a theoretical physicist, and a member of the French Academy of Sciences. This book is the translation, by Eric Novak, of the original French Si Einstein m'etait conte (Le Cherche Midi, 2005). It is neither a book of theoretical physics nor a biography of Einstein. It is not a book of history nor philosophy of science. In Damour's words it was written to encourage the reader to share with Einstein 'those times when he understood some part of the hidden order of the universe'. It is a relatively short book, written in a very fluent style, but it deals with all the major problems and achievements of Einstein's works. Starting from special relativity, it continues with general relativity, quantum theories, unified field theory and a brief overview of the actual research related to Einstein's legacy. It is essentially a popular science book with some related exploration in history and philosophy to interpret physical theories. The most important problem discussed by Damour is the nature of time. On this subject, there is a very interesting short paragraph (pp 33--35) dedicated to the reception of the relativity idea by the great writer Marcel Proust and its counterpart within A la Recherche du Temps Perdu. A correct discussion of the implications of a relativistic time should imply the distinction of the different possible interpretations of this concept. Damour seems to conclude that only one interpretation is possible: 'time does not exist', flowing of time is an illusion. One has to know that Einstein's ideas on time were related to Spinoza's perspective of a knowledge sub specie aeternitatis. However, other interpretations are possible and are related to the idea of time as an actuality. Damour speaks about the controversy between Einstein and Bergson, but Bergson is considered as a philosopher who did not understand relativity. This philosophical problem of relativistic time is indeed related to a historical problem briefly discussed by Damour

  12. Possible Anandamide and Palmitoylethanolamide involvement in human stroke

    Directory of Open Access Journals (Sweden)

    Pizzolato Gilberto

    2010-05-01

    Full Text Available Abstract Background Endocannabinoids (eCBs are ubiquitous lipid mediators that act on specific (CB1, CB2 and non-specific (TRPV1, PPAR receptors. Despite many experimental animal studies proved eCB involvement in the pathogenesis of stroke, such evidence is still lacking in human patients. Our aim was to determine eCB peripheral levels in acute stroke patients and evaluate their relationship with clinical disability and stroke volume. Methods A cohort of ten patients with a first acute (within six hours since symptoms onset ischemic stroke and a group of eight age- and sex-matched normal subjects were included. Groups were also matched for metabolic profile. All subjects underwent a blood sample collection for anandamide (AEA, 2-arachidonoylglycerol (2-AG and palmitoylethanolamide (PEA measurement; blood sampling was repeated in patients on admission (T0, at 6 (T1 and 18 hours (T2 thereafter. Patients neurological impairment was assessed using NIHSS and Fugl-Meyer Scale arm subitem (FMSa; stroke volume was determined on 48 h follow-up brain CT scans. Blood samples were analyzed by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. Results 1T0 AEA levels were significantly higher in stroke patients compared to controls. 2A significant inverse correlation between T0 AEA levels and FMSa score was found. Moreover a positive correlation between T0 AEA levels and stroke volume were found in stroke patients. T0 PEA levels in stroke patients were not significantly different from the control group, but showed a significant correlation with the NIHSS scores. T0 2-AG levels were lower in stroke patients compared to controls, but such difference did not reach the significance threshold. Conclusions This is the first demonstration of elevated peripheral AEA levels in acute stroke patients. In agreement with previous murine studies, we found a significant relationship between AEA or PEA levels and neurological involvement, such

  13. Albert einstein - Illustrated biography

    International Nuclear Information System (INIS)

    Sugimoto, K.

    1990-01-01

    A genius of science, but also a great-hearted man who fought his convictions all his life long. That is the Albert Einstein s portrait what draw the documents collected in this book: photographies, talks, letters and narrations, sometimes unpublished. With evidences and anecdotes is drawn a surprising personality of a man full of humor and originality who made his mark, as nobody else, in this tumultuous century. (N.C.)

  14. Einstein y la complejidad

    Directory of Open Access Journals (Sweden)

    Jou, David

    2007-12-01

    Full Text Available We study Einstein’s contributions to thermodynamics and statistical physics and their influence on some fields of physics which have led to current studies on complexity. We focus our attention on the use of fluctuations and entropy as a common framework for light and matter, whcich leds him to some of his fundamental contributions (phtoelectric effect, Brownian motion, specific heat of solids, stimulated light emission, Bose-Einstein condensation. We underline some aspects of Einstein’s research style: extrapolations, analogies, simplifications. We underline the relationship between light and matter as a common link of his researches in statistical physics.Presentamos las contribuciones de Einstein a la termodinámica y la mecánica estadística y su resonancia en ramas de la física que han conducido hasta la consideración actual de lo complejo. Nos referimos especialmente al uso de las fluctuaciones y de la entropía como marco común y nexo de unión entre luz y materia, que le conducen a algunas de sus aportaciones fundamentales (efecto fotoeléctrico, movimiento browniano, calor específico de los sólidos, emisión estimulada de la luz, condensación de Bose-Einstein. Consideramos también algunas facetas del estilo de investigación de Einstein, que se manifiestan con especial claridad en este campo: extrapolaciones, analogías, simplificaciones. Destacamos especialmente la importancia de la relación entre luz y materia en sus investigaciones.

  15. Simplifications of Einstein supergravity

    International Nuclear Information System (INIS)

    Ferrara, S.; van Nieuwenhuizen, P.

    1979-01-01

    Using a new symmetry of the Einstein supergravity action and defining a new spin connection, the axial-vector auxiliary field cancels in the gauge action and in the gauge algebra. This explains why in some models a first-order formalism with minimal coupling of the spin connection and tensor calculus agree, while in other models only the tensor calculus gives the correct result but torsion does not

  16. Seeking an African Einstein

    Science.gov (United States)

    Durrani, Matin

    2008-07-01

    A new postgraduate centre for maths and computer science is set to open in the Nigerian capital of Abuja this month as part of an ambitious plan to find the "next Einstein" in Africa. The centre will provide advanced training to graduate students from across Africa in maths and related fields. It will seek to attract the best young African scientists and nurture their talents as problem-solvers and teachers.

  17. Conflicts of interest in research involving human beings.

    Science.gov (United States)

    Greco, Dirceu; Diniz, Nilza Maria

    2008-01-01

    Conflicts of interest are inherent to the majority of relationships among individuals and of these with companies and institutions and, certainly, research involving human beings is no exception. In relation to clinical research, the main focus of this manuscript, conflicts of interest occur at different levels and usually permeate among them: In the pharmaceutical industry in their decisions to invest to develop new products, especially vaccines and drugs, and also in relation to marketing of these products; Among the investigators the conflicts may be related to the financial gains to participate in pharma sponsored trials, or to the expected academic career boost attained with the publication of the results of the trials and also to personal interests such as the financial support for trips to international conferences. Often the participation of host country investigators is restricted to performing phase III or IV protocols developed abroad, many times with low scientific relevance, and even lower relevance to public health; Universities or research institutes themselves also have conflicts of interest, as the sponsored projects may help increase their budgets, both directly (taxes) and indirectly (e.g., improvement of physical infrastructure of laboratories or out patient clinics); For the trial volunteers in developing countries, and Brazil is no exception despite free and universal access to its health system, participation in clinical trials is many times seen as, and can really be, an unique opportunity of receiving better health care, better treatment by the health professionals, easier access to costly lab exams and also to receiving certain medications which would otherwise be difficult to have access to. In order to handle these conflicts of interest, Brazil has a well-established and respected legal support and ethical normatization. The latter is represented by Resolution 196/96 of the Brazilian National Research Ethics Committee (CONEP). This

  18. Einstein the searcher his work explained from dialogues with Einstein

    CERN Document Server

    Moszkowski, Alexander

    2014-01-01

    This volume, first published in 1921, presents a series of portraits of Einstein, thus offering glimpses in the character and private reflections of the man who changed the course of modern science. Intended neither as a biography, nor as a résumé of Einsteinian physics, Einstein: The Searcher instead focusses on Einstein's relationship with the scientific project as he himself conceived it, and so is still of contemporary significance for those puzzled by the spirit of scientific enquiry.

  19. Albert Einstein, Analogizer Extraordinaire

    CERN Multimedia

    CERN. Geneva

    2007-01-01

    Where does deep insight in physics come from? It is tempting to think that it comes from the purest and most precise of reasoning, following ironclad laws of thought that compel the clear mind completely rigidly. And yet the truth is quite otherwise. One finds, when one looks closely at any major discovery, that the greatest of physicists are, in some sense, the most crazily daring and irrational of all physicists. Albert Einstein exemplifies this thesis in spades. In this talk I will describe the key role, throughout Albert Einstein's fabulously creative life, played by wild guesses made by analogy lacking any basis whatsoever in pure reasoning. In particular, in this year of 2007, the centenary of 1907, I will describe how over the course of two years (1905 through 1907) of pondering, Einstein slowly came, via analogy, to understand the full, radical consequences of the equation that he had first discovered and published in 1905, arguably the most famous equation of all time: E = mc2.

  20. Einstein's Years in Switzerland

    Science.gov (United States)

    Plendl, Hans S.

    2005-11-01

    Albert Einstein left Germany, the country of his birth, in 1894 and moved to Switzerland in 1895. He studied, worked and taught there, except for a year's stay in Prague, until1914. That year he returned to Germany, where he lived until his emigration to the United States in 1933. In 1905, while living with his wife Mileva and their first son Hans Albert in Bern and working as a technical expert at the Swiss Patent Office, he published his dissertation on the determination of molecular dimensions, his papers on Brownian Motion that helped to establish the Kinetic Theory of Heat and on the Photo-Electric Effect that validated the Quantum Theory of Light, and the two papers introducing the Special Theory of Relativity. How the young Einstein could help to lay the foundations of these theories while still working on his dissertation, holding a full-time job and helping to raise a family has evoked much discussion among his biographers. In this contribution, the extent to which living within Swiss society and culture could have made this feat possible will be examined. Old and recent photos of places in Switzerland where Einstein has lived and worked will be shown.

  1. A centennial gift from Einstein

    Science.gov (United States)

    Oswalt, T. D.

    2017-06-01

    The 1919 detection of the apparent displacement of background stars near the edge of the eclipsed Sun's disk provided one of the first convincing proofs of Einstein's theory of general relativity (1, 2). Almost 100 years later, Sahu et al. report on page 1046 of this issue the first measurement of the gravitational deflection of starlight by a star other than the Sun (3). Using the superior angular resolution of the Hubble Space Telescope (HST), they measured shifts in the apparent position of a distant background star as a nearby dense stellar remnant called a white dwarf passed almost in front of it in 2014. Because of the relative distances involved, the deflections they observed were about 1000 times smaller than those seen in 1919, but also in agreement with general relativity theory.

  2. Human Factors in Accidents Involving Remotely Piloted Aircraft

    Science.gov (United States)

    Merlin, Peter William

    2013-01-01

    This presentation examines human factors that contribute to RPA mishaps and provides analysis of lessons learned. RPA accident data from U.S. military and government agencies were reviewed and analyzed to identify human factors issues. Common contributors to RPA mishaps fell into several major categories: cognitive factors (pilot workload), physiological factors (fatigue and stress), environmental factors (situational awareness), staffing factors (training and crew coordination), and design factors (human machine interface).

  3. Einstein, Bohr, and Bell

    Science.gov (United States)

    Bellac, Michel Le

    2014-11-01

    The final form of quantum physics, in the particular case of wave mechanics, was established in the years 1925-1927 by Heisenberg, Schrödinger, Born and others, but the synthesis was the work of Bohr who gave an epistemological interpretation of all the technicalities built up over those years; this interpretation will be examined briefly in Chapter 10. Although Einstein acknowledged the success of quantum mechanics in atomic, molecular and solid state physics, he disagreed deeply with Bohr's interpretation. For many years, he tried to find flaws in the formulation of quantum theory as it had been more or less accepted by a large majority of physicists, but his objections were brushed away by Bohr. However, in an article published in 1935 with Podolsky and Rosen, universally known under the acronym EPR, Einstein thought he had identified a difficulty in the by then standard interpretation. Bohr's obscure, and in part beyond the point, answer showed that Einstein had hit a sensitive target. Nevertheless, until 1964, the so-called Bohr-Einstein debate stayed uniquely on a philosophical level, and it was actually forgotten by most physicists, as the few of them aware of it thought it had no practical implication. In 1964, the Northern Irish physicist John Bell realized that the assumptions contained in the EPR article could be tested experimentally. These assumptions led to inequalities, the Bell inequalities, which were in contradiction with quantum mechanical predictions: as we shall see later on, it is extremely likely that the assumptions of the EPR article are not consistent with experiment, which, on the contrary, vindicates the predictions of quantum physics. In Section 3.2, the origin of Bell's inequalities will be explained with an intuitive example, then they will be compared with the predictions of quantum theory in Section 3.3, and finally their experimental status will be reviewed in Section 3.4. The debate between Bohr and Einstein goes much beyond a

  4. New Information about Albert Einstein's Brain.

    Science.gov (United States)

    Falk, Dean

    2009-01-01

    In order to glean information about hominin (or other) brains that no longer exist, details of external neuroanatomy that are reproduced on endocranial casts (endocasts) from fossilized braincases may be described and interpreted. Despite being, of necessity, speculative, such studies can be very informative when conducted in light of the literature on comparative neuroanatomy, paleontology, and functional imaging studies. Albert Einstein's brain no longer exists in an intact state, but there are photographs of it in various views. Applying techniques developed from paleoanthropology, previously unrecognized details of external neuroanatomy are identified on these photographs. This information should be of interest to paleoneurologists, comparative neuroanatomists, historians of science, and cognitive neuroscientists. The new identifications of cortical features should also be archived for future scholars who will have access to additional information from improved functional imaging technology. Meanwhile, to the extent possible, Einstein's cerebral cortex is investigated in light of available data about variation in human sulcal patterns. Although much of his cortical surface was unremarkable, regions in and near Einstein's primary somatosensory and motor cortices were unusual. It is possible that these atypical aspects of Einstein's cerebral cortex were related to the difficulty with which he acquired language, his preference for thinking in sensory impressions including visual images rather than words, and his early training on the violin.

  5. Einstein algebras and general relativity

    International Nuclear Information System (INIS)

    Heller, M.

    1992-01-01

    A purely algebraic structure called an Einstein algebra is defined in such a way that every spacetime satisfying Einstein's equations is an Einstein algebra but not vice versa. The Gelfand representation of Einstein algebras is defined, and two of its subrepresentations are discussed. One of them is equivalent to the global formulation of the standard theory of general relativity; the other one leads to a more general theory of gravitation which, in particular, includes so-called regular singularities. In order to include other types of singularities one must change to sheaves of Einstein algebras. They are defined and briefly discussed. As a test of the proposed method, the sheaf of Einstein algebras corresponding to the space-time of a straight cosmic string with quasiregular singularity is constructed. 22 refs

  6. TOXICOLOGICAL RESEARCH INVOLVING HUMANS: ETHICAL AND REGULATORY CONSIDERATIONS

    Science.gov (United States)

    This paper discusses the need for the Society of Toxicology (SOT) to develop a policy for ethical research in humans, and a review for publication of these studies. Observations on human beings have been the foundation upon which toxicologic knowledge has been built since the in...

  7. How Einstein changed the world

    International Nuclear Information System (INIS)

    Boudenot, J.C.

    2005-01-01

    This book allows the reader to understand in a simple but detailed way the importance of the work of Einstein and its implications in the physics of today. The author first draws a biography of Einstein, then outlines the knowledge of physics at the beginning of the twentieth century, then describes the major contributions of Einstein to the brownian motion, the mass-energy equivalence, relativity and the notion of quantum, and ends by showing that the life-long Einstein's quest for a unitarian theory is still a present-day issue. (A.C.)

  8. Cloning of Novel Oncogenes Involved in Human Breast Cancer

    National Research Council Canada - National Science Library

    Clark, Geoffrey

    1998-01-01

    .... In order to identify genes which may play a role in breast cancer we have begun a process of manufacturing cDNA expression libraries derived from human breast tumor cell lines in retroviral vectors...

  9. The Einstein dossiers science and politics - Einstein's Berlin period with an appendix on Einstein's FBI file

    CERN Document Server

    Grundmann, Siegfried

    2004-01-01

    In 1919 the Prussian Ministry of Science, Arts and Culture opened a dossier on "Einstein's Theory of Relativity." It was rediscovered by the author in 1961 and is used in conjunction with numerous other subsequently identified 'Einstein' files as the basis of this fascinating book. In particular, the author carefully scrutinizes Einstein's FBI file from 1950-55 against mostly unpublished material from European including Soviet sources and presents hitherto unknown documentation on Einstein's alleged contacts with the German Communist Party and the Comintern. Siegfried Grundmann's thorough study of Einstein's participation on a committee of the League of Nations, based on archival research in Geneva, is also new. This book outlines Einstein's image in politics and German science policy. It covers the period from his appointment as a researcher in Berlin to his fight abroad against the "boycott of German science" after World War I and his struggle at home against attacks on "Jewish physics" of which he was made...

  10. Einstein's theory recovered

    International Nuclear Information System (INIS)

    Sebestyen, A.

    1980-11-01

    It is shown that a consequent treatment of local Lorentz invariance and of the group of translations as a gauge symmetry group necessarily leads to theories in which torsion has no place. It is also shown that the requirement of symmetry under Lorentz gauge tranformations leads to the emergence of the conventional √-gR additive term, responsible for the effects of gravitation, in the Lagrangian. It is thus proved that Einstein's general relativity is a unique consequence of the requirements of invariance under translations and Lorentz transformations. (author)

  11. Micronucleus formation in cultured human keratinocytes: Involvement of intercellular bioactivation.

    Science.gov (United States)

    van Pelt, F N; Haring, R M; Weterings, P J

    1991-01-01

    Micronucleus formation in cultured human keratinocytes was studied after exposure to benzo[a]pyrene, cyclophosphamide and 12-O-tetradecanoylphorbol-13-acetate without the addition of an exogenous metabolizing system. The first two agents need bioactivation by specific isoenzymes of cytochrome P-450 to form genotoxic intermediates. Benzo[a]pyrene induced the micronucleus formation in both uninduced and Aroclor 1254-pretreated cultures. Clastogenic effects of cyclophosphamide were observed only in Aroclor 1254-pretreated cells. The tumour promotor 12-O-tetradecanoylphorbol-13-acetate did not affect the frequency of micronuclei in human keratinocytes. The data indicate that cultured human keratinocytes can be used to study the tissue-specific response to genotoxic agents as well as interindividual variation in biotransformation capacity.

  12. Microenvironment involved in FPR1 expression by human glioblastomas

    NARCIS (Netherlands)

    Boer, J. C.; van Marion, D. M S; Joseph, J. V.; Kliphuis, N. M.; Timmer-Bosscha, H.; van Strijp, J. A G; de Vries, E. G E; den Dunnen, W. F A; Kruyt, F. A E; Walenkamp, A. M E

    2015-01-01

    Formyl peptide receptor 1 (FPR1) activity in U87 glioblastoma (GBM) cells contributes to tumor cell motility. The present study aimed to evaluate the FPR1 expression in human GBM, the possibility to elicit agonist induced FPR1 activation of GBM cells and inhibit this activation with chemotaxis

  13. Microenvironment involved in FPR1 expression by human glioblastomas

    NARCIS (Netherlands)

    Boer, J. C.; van Marion, D. M. S.; Vareecal Joseph, J.; Kliphuis, N. M.; Timmer-Bosscha, H.; van Strijp, J. A. G.; de Vries, E. G. E.; den Dunnen, W. F. A.; Kruyt, F. A. E.; Walenkamp, A. M. E.

    Formyl peptide receptor 1 (FPR1) activity in U87 glioblastoma (GBM) cells contributes to tumor cell motility. The present study aimed to evaluate the FPR1 expression in human GBM, the possibility to elicit agonist induced FPR1 activation of GBM cells and inhibit this activation with chemotaxis

  14. Predictive Mechanisms Are Not Involved the Same Way during Human-Human vs. Human-Machine Interactions: A Review

    Directory of Open Access Journals (Sweden)

    Aïsha Sahaï

    2017-10-01

    Full Text Available Nowadays, interactions with others do not only involve human peers but also automated systems. Many studies suggest that the motor predictive systems that are engaged during action execution are also involved during joint actions with peers and during other human generated action observation. Indeed, the comparator model hypothesis suggests that the comparison between a predicted state and an estimated real state enables motor control, and by a similar functioning, understanding and anticipating observed actions. Such a mechanism allows making predictions about an ongoing action, and is essential to action regulation, especially during joint actions with peers. Interestingly, the same comparison process has been shown to be involved in the construction of an individual's sense of agency, both for self-generated and observed other human generated actions. However, the implication of such predictive mechanisms during interactions with machines is not consensual, probably due to the high heterogeneousness of the automata used in the experimentations, from very simplistic devices to full humanoid robots. The discrepancies that are observed during human/machine interactions could arise from the absence of action/observation matching abilities when interacting with traditional low-level automata. Consistently, the difficulties to build a joint agency with this kind of machines could stem from the same problem. In this context, we aim to review the studies investigating predictive mechanisms during social interactions with humans and with automated artificial systems. We will start by presenting human data that show the involvement of predictions in action control and in the sense of agency during social interactions. Thereafter, we will confront this literature with data from the robotic field. Finally, we will address the upcoming issues in the field of robotics related to automated systems aimed at acting as collaborative agents.

  15. Einstein and the "Crucial" Experiment

    Science.gov (United States)

    Holton, Gerald

    1969-01-01

    Examines the widespread view that it was the crucial Michelson-Morley experiment that led Einstein to formulate the special relativity theory. From Einstein's writings, evidence is presented that no such direct genetic connection exists. The author suggests that the historian of science must resist the experimenticist's fallacy of imposing a…

  16. Albert Einstein 1879-1955.

    Science.gov (United States)

    Physics Today, 1979

    1979-01-01

    Celebrates the centennial of Einstein's birth with an eight-page pictorial biography and two special articles: (1) Einstein the catalyst; and (2) Unitary field theories. His special and general theories of relativity and his contributions to quantum physics and other topics are also presented. (HM)

  17. Albert Einstein: A Biographical Sketch

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 4. Albert Einstein: A Biographical Sketch. Maja Winteler-Einstein. Reflections Volume 5 Issue 4 April 2000 pp 111-120. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/005/04/0111-0120 ...

  18. Solutions of Einstein's field equations

    Energy Technology Data Exchange (ETDEWEB)

    Tomonaga, Y [Utsunomiya Univ. (Japan). Faculty of Education

    1978-12-01

    In this paper the author investigates the Einstein's field equations of the non-vacuum case and generalizes the solution of Robertson-Walker by the three dimensional Einstein spaces. In Section 2 the author shortly generalizes the dynamic space-time of G. Lemetre and A. Friedmann by a simple transformation.

  19. Einstein's first paper on relativity

    International Nuclear Information System (INIS)

    Schwartz, H.M.

    1977-01-01

    Because of its exceptional significance in the history of great ideas in science, Einstein's first paper on relativity, especially its first part, deserves a more careful translation into English than presently exists. A new and annotated translation of this first part is presented here, together with a brief discussion of certain aspects of Einstein's paper

  20. Einstein, Entropy and Anomalies

    Science.gov (United States)

    Sirtes, Daniel; Oberheim, Eric

    2006-11-01

    This paper strengthens and defends the pluralistic implications of Einstein's successful, quantitative predictions of Brownian motion for a philosophical dispute about the nature of scientific advance that began between two prominent philosophers of science in the second half of the twentieth century (Thomas Kuhn and Paul Feyerabend). Kuhn promoted a monistic phase-model of scientific advance, according to which a paradigm driven `normal science' gives rise to its own anomalies, which then lead to a crisis and eventually a scientific revolution. Feyerabend stressed the importance of pluralism for scientific progress. He rejected Kuhn's model arguing that it fails to recognize the role that alternative theories can play in identifying exactly which phenomena are anomalous in the first place. On Feyerabend's account, Einstein's predictions allow for a crucial experiment between two incommensurable theories, and are an example of an anomaly that could refute the reigning paradigm only after the development of a competitor. Using Kuhn's specification of a disciplinary matrix to illustrate the incommensurability between the two paradigms, we examine the different research strategies available in this peculiar case. On the basis of our reconstruction, we conclude by rebutting some critics of Feyerabend's argument.

  1. Einstein Inflationary Probe (EIP)

    Science.gov (United States)

    Hinshaw, Gary

    2004-01-01

    I will discuss plans to develop a concept for the Einstein Inflation Probe: a mission to detect gravity waves from inflation via the unique signature they impart to the cosmic microwave background (CMB) polarization. A sensitive CMB polarization satellite may be the only way to probe physics at the grand-unified theory (GUT) scale, exceeding by 12 orders of magnitude the energies studied at the Large Hadron Collider. A detection of gravity waves would represent a remarkable confirmation of the inflationary paradigm and set the energy scale at which inflation occurred when the universe was a fraction of a second old. Even a strong upper limit to the gravity wave amplitude would be significant, ruling out many common models of inflation, and pointing to inflation occurring at much lower energy, if at all. Measuring gravity waves via the CMB polarization will be challenging. We will undertake a comprehensive study to identify the critical scientific requirements for the mission and their derived instrumental performance requirements. At the core of the study will be an assessment of what is scientifically and experimentally optimal within the scope and purpose of the Einstein Inflation Probe.

  2. Einstein-Rosen gravitational waves

    International Nuclear Information System (INIS)

    Astefanoaei, Iordana; Maftei, Gh.

    2001-01-01

    In this paper we analyse the behaviour of the gravitational waves in the approximation of the far matter fields, considering the indirect interaction between the matter sources and the gravitational field, in a cosmological model based on the Einstein-Rosen solution, Because the properties of the gravitational waves obtained as the solutions of Einstein fields equations (the gravitational field equations) are most obvious in the weak gravitational fields we consider here, the gravitational field in the linear approximation. Using the Newman-Penrose formalism, we calculate in the null-tetradic base (e a ), the spin coefficients, the directional derivates and the tetradic components of Ricci and Weyl tensors. From the Einstein field equations we obtained the solution for b(z, t) what described the behaviour of gravitational wave in Einstein-Rosen Universe and in the particular case, when t → ∞, p(z, t) leads us to the primordial gravitational waves in the Einstein-Rosen Universe. (authors)

  3. Taming the nonlinearity of the Einstein equation.

    Science.gov (United States)

    Harte, Abraham I

    2014-12-31

    Many of the technical complications associated with the general theory of relativity ultimately stem from the nonlinearity of Einstein's equation. It is shown here that an appropriate choice of dynamical variables may be used to eliminate all such nonlinearities beyond a particular order: Both Landau-Lifshitz and tetrad formulations of Einstein's equation are obtained that involve only finite products of the unknowns and their derivatives. Considerable additional simplifications arise in physically interesting cases where metrics become approximately Kerr or, e.g., plane waves, suggesting that the variables described here can be used to efficiently reformulate perturbation theory in a variety of contexts. In all cases, these variables are shown to have simple geometrical interpretations that directly relate the local causal structure associated with the metric of interest to the causal structure associated with a prescribed background. A new method to search for exact solutions is outlined as well.

  4. CHL1 is involved in human breast tumorigenesis and progression

    Energy Technology Data Exchange (ETDEWEB)

    He, Li-Hong [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Ma, Qin [Department of Oncology, The General Hospital of Tianjin Medical University, Tianjin (China); Shi, Ye-Hui [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Ge, Jie; Zhao, Hong-Meng [Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Li, Shu-Fen [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Tong, Zhong-Sheng, E-mail: 83352162@qq.com [Medical Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

    2013-08-23

    Highlights: •CHL1 is down-regulation in breast cancer tissues. •Down-regulation of CHL1 is related to high grade. •Overexpression of CHL1 inhibits breast cancer cell proliferation and invasion in vitro. •CHL1 deficiency induces breast cancer cell proliferation and invasion both in vitro and in vivo. -- Abstract: Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited. Here, we found that CHL1 is down-regulated in human breast cancer and related to lower grade. Furthermore, overexpression of CHL1 suppresses proliferation and invasion in MDA-MB-231 cells and knockdown of CHL1 expression results in increased proliferation and invasion in MCF7 cells in vitro. Finally, CHL1 deficiency promotes tumor formation in vivo. Our results may provide a strategy for blocking breast carcinogenesis and progression.

  5. CHL1 is involved in human breast tumorigenesis and progression

    International Nuclear Information System (INIS)

    He, Li-Hong; Ma, Qin; Shi, Ye-Hui; Ge, Jie; Zhao, Hong-Meng; Li, Shu-Fen; Tong, Zhong-Sheng

    2013-01-01

    Highlights: •CHL1 is down-regulation in breast cancer tissues. •Down-regulation of CHL1 is related to high grade. •Overexpression of CHL1 inhibits breast cancer cell proliferation and invasion in vitro. •CHL1 deficiency induces breast cancer cell proliferation and invasion both in vitro and in vivo. -- Abstract: Neural cell adhesion molecules (CAM) play important roles in the development and regeneration of the nervous system. The L1 family of CAMs is comprised of L1, Close Homolog of L1 (CHL1, L1CAM2), NrCAM, and Neurofascin, which are structurally related trans-membrane proteins in vertebrates. Although the L1CAM has been demonstrated play important role in carcinogenesis and progression, the function of CHL1 in human breast cancer is limited. Here, we found that CHL1 is down-regulated in human breast cancer and related to lower grade. Furthermore, overexpression of CHL1 suppresses proliferation and invasion in MDA-MB-231 cells and knockdown of CHL1 expression results in increased proliferation and invasion in MCF7 cells in vitro. Finally, CHL1 deficiency promotes tumor formation in vivo. Our results may provide a strategy for blocking breast carcinogenesis and progression

  6. Efficient involvement of human resources in innovations through effective communication

    Directory of Open Access Journals (Sweden)

    Katarína Stachova

    2017-05-01

    Full Text Available Systematic creation and use of human potential enables building and development of strengths of organisations. If organisations can fully use the potential of their employees it will affect their ability to succeed in competitive environment. Our paper focuses on open and broad communication, as it has a significant impact on both formal and informal labour relations, which, along with information share and knowledge continuity, essentially affect team creation. The questionnaire survey focused on finding out whether and to what extent organisations operating in Slovakia focus on communication. The paper also provides a simple method of evaluating the level of communication and engagement of employees in problem solving in companies. This method is a simple instrument enabling the conduction of analysis in a short time interval, while analysing employees are able to identify a current level of their company on the grounds of results, as well as they are able to identify bottlenecks preventing them in innovation potential increase.

  7. Neutrinos and Einstein

    CERN Document Server

    Suzuki, Yoichiro

    2005-01-01

    A tiny neutrino mass is a clue to the physics beyond the standard model of elementary particle physics. The primary cosmic rays, mostly protons, are created and accelerated to the relativistic energy in supernova remnants. They traverse the universe and reach the earth. The incoming primary cosmic rays interact with the earth's atmosphere to produce secondary particles, which subsequently decay into neutrinos, called atmospheric neutrinos. The atmospheric neutrinos have shown the evidence of the finite neutrino masses through the phenomena called neutrino oscillations. Neutrinos are detected by large detectors underground like, for example, Super-Kamiokande, SNO and KamLAND. Those detectors use large photomultiplier tubes, which make use of the photo-electric effect to convert photons created by the interaction of neutrinos to electrons to form electric pulses. Neutrinos are therefore created and detected by "Einstein" and have step forward beyond the current physics. Neutrinos may also carry a hit to the ori...

  8. Genes involved in immortalization of human mammary cells

    Energy Technology Data Exchange (ETDEWEB)

    Stampfer, Martha R.; Yaswen, Paul

    2001-09-27

    Breast cancer progression is characterized by inappropriate cell growth. Normal cells cease growth after a limited number of cell divisions--a process called cellular senescence-while tumor cells may acquire the ability to proliferate indefinitely (immortality). Inappropriate expression of specific oncogenes in a key cellular signaling pathway (Ras, Raf) can promote tumorigenicity in immortal cells, while causing finite lifespan cells to undergo a rapid senescence-like arrest. We have studied when in the course of transformation of cultured human mammary epithelial cells (HMEC), the response to overexpressed oncogenic Raf changes from being tumor-suppressive to tumor enhancing, and what are the molecular underpinnings of this response. Our data indicate: (1) HMEC acquire the ability to maintain growth in the presence of oncogenic Raf not simply as a consequence of overcoming senescence, but as a result of a newly discovered step in the process of immortal transformation uncovered by our lab, termed conversion. Immortal cells that have not undergone conversion (e.g., cells immortalized by exogenous introduction of the immortalizing enzyme, telomerase) remain growth inhibited. (2) Finite lifespan HMEC growth arrest in response to oncogenic Raf using mediators of growth inhibition that are very different from those used in response to oncogenic Raf by rodent cells and certain other human cell types, including the connective tissue cells from the same breast tissue. While many diverse cell types appear to have in common a tumor-suppressive response to this oncogenic signal, they also have developed multiple mechanisms to elicit this response. Understanding how cancer cells acquire the crucial capacity to be immortal and to abrogate normal tumor-suppressive mechanisms may serve both to increase our understanding of breast cancer progression, and to provide new targets for therapeutic intervention. Our results indicate that normal HMEC have novel means of enforcing a Raf

  9. Predicting Genes Involved in Human Cancer Using Network Contextual Information

    Directory of Open Access Journals (Sweden)

    Rahmani Hossein

    2012-03-01

    Full Text Available Protein-Protein Interaction (PPI networks have been widely used for the task of predicting proteins involved in cancer. Previous research has shown that functional information about the protein for which a prediction is made, proximity to specific other proteins in the PPI network, as well as local network structure are informative features in this respect. In this work, we introduce two new types of input features, reflecting additional information: (1 Functional Context: the functions of proteins interacting with the target protein (rather than the protein itself; and (2 Structural Context: the relative position of the target protein with respect to specific other proteins selected according to a novel ANOVA (analysis of variance based measure. We also introduce a selection strategy to pinpoint the most informative features. Results show that the proposed feature types and feature selection strategy yield informative features. A standard machine learning method (Naive Bayes that uses the features proposed here outperforms the current state-of-the-art methods by more than 5% with respect to F-measure. In addition, manual inspection confirms the biological relevance of the top-ranked features.

  10. Attribution of human characteristics and bullying involvement in childhood: Distinguishing between targets

    NARCIS (Netherlands)

    Noorden, T.H.J. van; Haselager, G.J.T.; Lansu, T.A.M.; Cillessen, A.H.N.; Bukowski, W.M.

    2016-01-01

    This investigation researched the association between the attribution of human characteristics and bullying involvement in children by distinguishing between targets. Study 1 focused on the attribution of human characteristics by bullies, victims, bully/victims, and non-involved children toward

  11. Involvement of the mitochondrial compartment in human NCL fibroblasts

    International Nuclear Information System (INIS)

    Pezzini, Francesco; Gismondi, Floriana; Tessa, Alessandra; Tonin, Paola; Carrozzo, Rosalba; Mole, Sara E.; Santorelli, Filippo M.; Simonati, Alessandro

    2011-01-01

    Highlights: ► Mitochondrial reticulum fragmentation occurs in human CLN1 and CLN6 fibroblasts. ► Likewise mitochondrial shift-to periphery and decreased mitochondrial density are seen. ► Enhanced caspase-mediated apoptosis occurs following STS treatment in CLN1 fibroblasts. -- Abstract: Neuronal ceroid lipofuscinosis (NCL) are a group of progressive neurodegenerative disorders of childhood, characterized by the endo-lysosomal storage of autofluorescent material. Impaired mitochondrial function is often associated with neurodegeneration, possibly related to the apoptotic cascade. In this study we investigated the possible effects of lysosomal accumulation on the mitochondrial compartment in the fibroblasts of two NCL forms, CLN1 and CLN6. Fragmented mitochondrial reticulum was observed in all cells by using the intravital fluorescent marker Mitotracker, mainly in the perinuclear region. This was also associated with intense signal from the lysosomal markers Lysotracker and LAMP2. Likewise, mitochondria appeared to be reduced in number and shifted to the cell periphery by electron microscopy; moreover the mitochondrial markers VDCA and COX IV were reduced following quantitative Western blot analysis. Whilst there was no evidence of increased cell death under basal condition, we observed a significant increase in apoptotic nuclei following Staurosporine treatment in CLN1 cells only. In conclusion, the mitochondrial compartment is affected in NCL fibroblasts invitro, and CLN1 cells seem to be more vulnerable to the negative effects of stressed mitochondrial membrane than CLN6 cells.

  12. The Einstein tensor characterizing some Riemann spaces

    International Nuclear Information System (INIS)

    Rahman, M.S.

    1993-07-01

    A formal definition of the Einstein tensor is given. Mention is made of how this tensor plays a role of expressing certain conditions in a precise form. The cases of reducing the Einstein tensor to a zero tensor are studied on its merit. A lucid account of results, formulated as theorems, on Einstein symmetric and Einstein recurrent spaces is then presented. (author). 5 refs

  13. Is IGSF1 involved in human pituitary tumor formation?

    Science.gov (United States)

    Faucz, Fabio R; Horvath, Anelia D; Azevedo, Monalisa F; Levy, Isaac; Bak, Beata; Wang, Ying; Xekouki, Paraskevi; Szarek, Eva; Gourgari, Evgenia; Manning, Allison D; de Alexandre, Rodrigo Bertollo; Saloustros, Emmanouil; Trivellin, Giampaolo; Lodish, Maya; Hofman, Paul; Anderson, Yvonne C; Holdaway, Ian; Oldfield, Edward; Chittiboina, Prashant; Nesterova, Maria; Biermasz, Nienke R; Wit, Jan M; Bernard, Daniel J; Stratakis, Constantine A

    2015-02-01

    IGSF1 is a membrane glycoprotein highly expressed in the anterior pituitary. Pathogenic mutations in the IGSF1 gene (on Xq26.2) are associated with X-linked central hypothyroidism and testicular enlargement in males. In this study, we tested the hypothesis that IGSF1 is involved in the development of pituitary tumors, especially those that produce growth hormone (GH). IGSF1 was sequenced in 21 patients with gigantism or acromegaly and 92 healthy individuals. Expression studies with a candidate pathogenic IGSF1 variant were carried out in transfected cells and immunohistochemistry for IGSF1 was performed in the sections of GH-producing adenomas, familial somatomammotroph hyperplasia, and in normal pituitary. We identified the sequence variant p.N604T, which in silico analysis suggested could affect IGSF1 function, in two male patients and one female with somatomammotroph hyperplasia from the same family. Of 60 female controls, two carried the same variant and seven were heterozygous for other variants. Immunohistochemistry showed increased IGSF1 staining in the GH-producing tumor from the patient with the IGSF1 p.N604T variant compared with a GH-producing adenoma from a patient negative for any IGSF1 variants and with normal control pituitary tissue. The IGSF1 gene appears polymorphic in the general population. A potentially pathogenic variant identified in the germline of three patients with gigantism from the same family (segregating with the disease) was also detected in two healthy female controls. Variations in IGSF1 expression in pituitary tissue in patients with or without IGSF1 germline mutations point to the need for further studies of IGSF1 action in pituitary adenoma formation. © 2015 Society for Endocrinology.

  14. Correct Linearization of Einstein's Equations

    Directory of Open Access Journals (Sweden)

    Rabounski D.

    2006-06-01

    Full Text Available Regularly Einstein's equations can be reduced to a wave form (linearly dependent from the second derivatives of the space metric in the absence of gravitation, the space rotation and Christoffel's symbols. As shown here, the origin of the problem is that one uses the general covariant theory of measurement. Here the wave form of Einstein's equations is obtained in the terms of Zelmanov's chronometric invariants (physically observable projections on the observer's time line and spatial section. The obtained equations depend on solely the second derivatives even if gravitation, the space rotation and Christoffel's symbols. The correct linearization proves: the Einstein equations are completely compatible with weak waves of the metric.

  15. An Einstein-Goedel universe

    International Nuclear Information System (INIS)

    Vaidya, P.C.

    1978-01-01

    The metric for the standard static Einstein model of the universe can be expressed in coordinates for which a congruence of spacelike world lines of the model will be twisting. A method of 'shifting the twist' has been devised by which the twist on spacelike world lines is shifted onto the timelike world lines. The model universe then becomes Goedel's model. A combined Einstein-Goedel model containing a parameter epsilon is obtained. Switching epsilon from +1 to -1 will effect the shift of twist in the world lines and lead from the Einstein model to the Goedel model. (author)

  16. 75 FR 62738 - Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides...

    Science.gov (United States)

    2010-10-13

    ... addressed in EPA science and ethics reviews of proposed and completed human research for pesticides, based... Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides; Notification to... protection of human subjects of research that apply to third parties who conduct or support research for...

  17. 76 FR 5735 - Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides

    Science.gov (United States)

    2011-02-02

    ... addressed in EPA science and ethics reviews of proposed and completed human research with pesticides, drawn..., which suggest ethical considerations relevant to evaluation of human studies. Third, Petitioners argued... Revisions to EPA's Rule on Protections for Subjects in Human Research Involving Pesticides AGENCY...

  18. Einstein: The Gourmet of Creativity.

    Science.gov (United States)

    Greenberg, Joel

    1979-01-01

    Reports a psychiatrist's analysis of Einstein's personal account of how he developed the theory of relativity. The psychiatrist cites Janusian thinking, actively conceiving two or more opposite concepts simultaneously, as a characteristic of much creative thought in general. (MA)

  19. Physics before and after Einstein

    CERN Document Server

    Capria, M Mamone

    2005-01-01

    It is now a century ago that one of the icons of modern physics published some of the most influential scientific papers of all times. With his work on relativity and quantum theory, Albert Einstein has altered the field of physics forever. It should not come as a surprise that looking back at Einstein''s work, one needs to rethink the whole scope of physics, before and after his time. This books aims to provide a perspective on the history of modern physics, spanning from the late 19th century up to today. It is not an encyclopaedic work, but it presents the groundbreaking and sometimes provocative main contributions by Einstein as marking the line between ''old'' and ''new'' physics, and expands on some of the developments and open issues to which they gave rise.

  20. Einstein and the twin paradox

    International Nuclear Information System (INIS)

    Pesic, Peter

    2003-01-01

    Einstein was the first to discuss and resolve the 'twin paradox', which in 1905 he did not consider paradoxical and treated as a consequence of lack of simultaneity. He maintained this view until at least 1914. However, in 1918 Einstein brought forward arguments about accelerated frames of reference that tended to overshadow his initial resolution. His earlier arguments were gradually rediscovered during the subsequent controversy about this 'paradox'

  1. The NASA Beyond Einstein Program

    Science.gov (United States)

    White, Nicholas E.

    2006-01-01

    Einstein's legacy is incomplete, his theory of General relativity raises -- but cannot answer --three profound questions: What powered the big bang? What happens to space, time, and matter at the edge of a black hole? and What is the mysterious dark energy pulling the Universe apart? The Beyond Einstein program within NASA's Office of Space Science aims to answer these questions, employing a series of missions linked by powerful new technologies and complementary approaches towards shared science goals. The Beyond Einstein program has three linked elements which advance science and technology towards two visions; to detect directly gravitational wave signals from the earliest possible moments of the BIg Bang, and to image the event horizon of a black hole. The central element is a pair of Einstein Great Observatories, Constellation-X and LISA. Constellation-X is a powerful new X-ray observatory dedicated to X-Ray Spectroscopy. LISA is the first spaced based gravitational wave detector. These powerful facilities will blaze new paths to the questions about black holes, the Big Bang and dark energy. The second element is a series of competitively selected Einstein Probes, each focused on one of the science questions and includes a mission dedicated resolving the Dark Energy mystery. The third element is a program of technology development, theoretical studies and education. The Beyond Einstein program is a new element in the proposed NASA budget for 2004. This talk will give an overview of the program and the missions contained within it.

  2. The Einstein Slew Survey

    Science.gov (United States)

    Elvis, Martin; Plummer, David; Schachter, Jonathan; Fabbiano, G.

    1992-01-01

    A catalog of 819 sources detected in the Einstein IPC Slew Survey of the X-ray sky is presented; 313 of the sources were not previously known as X-ray sources. Typical count rates are 0.1 IPC count/s, roughly equivalent to a flux of 3 x 10 exp -12 ergs/sq cm s. The sources have positional uncertainties of 1.2 arcmin (90 percent confidence) radius, based on a subset of 452 sources identified with previously known pointlike X-ray sources (i.e., extent less than 3 arcmin). Identifications based on a number of existing catalogs of X-ray and optical objects are proposed for 637 of the sources, 78 percent of the survey (within a 3-arcmin error radius) including 133 identifications of new X-ray sources. A public identification data base for the Slew Survey sources will be maintained at CfA, and contributions to this data base are invited.

  3. Dimeric ligands for GPCRs involved in human reproduction : synthesis and biological evaluation

    NARCIS (Netherlands)

    Bonger, Kimberly Michelle

    2008-01-01

    Dimeric ligands for G-protein coupled receptors that are involved in human reproduction, namely the gonadotropin releasing hormone receptor, the luteinizing hormone receptor and the follicle-stimulating hormone receptor, were synthesized and biologically evaluated.

  4. Bose-Einstein Condensation

    International Nuclear Information System (INIS)

    Jaksch, D

    2003-01-01

    The Gross-Pitaevskii equation, named after one of the authors of the book, and its large number of applications for describing the properties of Bose-Einstein condensation (BEC) in trapped weakly interacting atomic gases, is the main topic of this book. In total the monograph comprises 18 chapters and is divided into two parts. Part I introduces the notion of BEC and superfluidity in general terms. The most important properties of the ideal and the weakly interacting Bose gas are described and the effects of nonuniformity due to an external potential at zero temperature are studied. The first part is then concluded with a summary of the properties of superfluid He. In Part II the authors describe the theoretical aspects of BEC in harmonically trapped weakly interacting atomic gases. A short and rather rudimentary chapter on collisions and trapping of atomic gases which seems to be included for completeness only is followed by a detailed analysis of the ground state, collective excitations, thermodynamics, and vortices as well as mixtures of BECs and the Josephson effect in BEC. Finally, the last three chapters deal with topics of more recent interest like BEC in optical lattices, low dimensional systems, and cold Fermi gases. The book is well written and in fact it provides numerous useful and important relations between the different properties of a BEC and covers most of the aspects of ultracold weakly interacting atomic gases from the point of view of condensed matter physics. The book contains a comprehensive introduction to BEC for physicists new to the field as well as a lot of detail and insight for those already familiar with this area. I therefore recommend it to everyone who is interested in BEC. Very clearly however, the intention of the book is not to provide prospects for applications of BEC in atomic physics, quantum optics or quantum state engineering and therefore the more practically oriented reader might sometimes wonder why exactly an equation is

  5. Einstein and Hilbert: The creation of general relativity

    International Nuclear Information System (INIS)

    Todorov, I.T.

    1992-12-01

    It took eight years after Einstein announced the basic physical ideas behind the relativistic gravity theory before the proper mathematical formulation of general-relativity was mastered. The efforts of the greatest physicist and of the greatest mathematician of the time was involved and reached a breathtaking concentration during the last month of the work. (author)

  6. CERN physicist receives Einstein Medal

    CERN Multimedia

    2006-01-01

    On 29 June the CERN theorist Gabriele Veneziano was awarded the prestigious Albert Einstein Medal for significant contributions to the understanding of string theory. This award is given by the Albert Einstein Society in Bern to individuals whose scientific contributions relate to the work of Einstein. Former recipients include exceptional physicists such as Murray Gell-Mann last year, but also Stephen Hawking and Victor Weisskopf. Gabriele Veneziano, a member of the integrated CERN Theory Team since 1977, led the Theory Division from 1994 to 1997 and has already received many prestigious prizes for his outstanding work, including the Enrico Fermi Prize (see CERN Courier, November 2005), the Dannie Heineman Prize for mathematical physics of the American Physical Society in 2004 (see Bulletin No. 47/2003), and the I. Ya. Pomeranchuk Prize of the Institute of Theoretical and Experimental Physics (Moscow) in 1999.

  7. The times of Albert Einstein

    International Nuclear Information System (INIS)

    Ahmad, S.M.W.

    1990-09-01

    ''The life of Albert Einstein has a dramatic quality that does not rest exclusively on his theory of relativity. The extravagant timing of history linked him with three shattering developments of the twentieth century: the rise and fall of Nazi Germany, the birth of nuclear weapons, and the birth of zionism (and Israel). Their impact on Einstein's genius combined to drive him into a contact with the affairs of the world for which Einstein had little taste''. This article is the result of my lecture delivered at ICTP on 17 August, 1990 before a knowledgable audience that included scientists from many countries including the third world countries. This one and half hour lecture was organised by Dr. A.M. Hamende and Dr. H.R. Dalafi. 10 refs

  8. Quantum theory and Einstein's general relativity

    International Nuclear Information System (INIS)

    Borzeszkowski, H.H.v.; Treder, H.J.

    1984-01-01

    The paper concerns Einstein's general relativity, wave mechanics and the quantization of Einstein's gravitation equations. The principle of equivalence and its association with both wave mechanics and quantum gravity, is discussed. (U.K.)

  9. Bose-Einstein condensation

    Indian Academy of Sciences (India)

    Science. His current research involves trapping of atoms to carry out high precision tests of ... experimental techniques involved in achieving it, and high- light some of the ... is n-1!3, and from kinetic theory, the mean de Broglie wavelength.

  10. Exact Solutions for Einstein's Hyperbolic Geometric Flow

    International Nuclear Information System (INIS)

    He Chunlei

    2008-01-01

    In this paper we investigate the Einstein's hyperbolic geometric flow and obtain some interesting exact solutions for this kind of flow. Many interesting properties of these exact solutions have also been analyzed and we believe that these properties of Einstein's hyperbolic geometric flow are very helpful to understanding the Einstein equations and the hyperbolic geometric flow

  11. Einstein for Schools and the General Public

    Science.gov (United States)

    Johansson, K. E.; Kozma, C; Nilsson, Ch

    2006-01-01

    In April 2005 the World Year of Physics (Einstein Year in the UK and Ireland) was celebrated with an Einstein week in Stockholm House of Science. Seven experiments illustrated Einstein's remarkable work in 1905 on Brownian motion, the photoelectric effect and special relativity. Thirteen school classes with 260 pupils, 30 teachers and 25 members…

  12. Series expansion of the modified Einstein Procedure

    Science.gov (United States)

    Seema Chandrakant Shah-Fairbank

    2009-01-01

    This study examines calculating total sediment discharge based on the Modified Einstein Procedure (MEP). A new procedure based on the Series Expansion of the Modified Einstein Procedure (SEMEP) has been developed. This procedure contains four main modifications to MEP. First, SEMEP solves the Einstein integrals quickly and accurately based on a series expansion. Next,...

  13. Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion

    DEFF Research Database (Denmark)

    Søe, Kent; Andersen, Thomas Lykke; Hobolt-Pedersen, Anne-Sofie

    2011-01-01

    fusion of the lipid bilayers of their cell membranes are still unknown. Syncytin-1 is a protein encoded by a human endogenous retroviral gene which was stably integrated into the human ancestor genome more than 24 million years ago. Upon activation, syncytin-1 is able to destabilize the lipid bilayer....... This was documented through Q-PCR, Western blot and immunofluorescence analyses. These in vitro findings were confirmed by immunohistochemical stainings in human iliac crest biopsies. A syncytin-1 inhibitory peptide reduced the number of nuclei per osteoclast by 30%, as well as TRACP activity. From a mechanistic...

  14. Dutch museum marks Einstein anniversary

    Science.gov (United States)

    van Calmthout, Matijn

    2016-01-01

    A new painting of Albert Einstein's field equation from his 1915 general theory of relativity was unveiled in a ceremony in November 2015 by the Dutch physicist Robbert Dijkgraaf, who is director of the Princeton Institute for Advanced Study in the US.

  15. Einstein's Legacy, at the Globe

    CERN Multimedia

    2005-01-01

    One-hundred years on, Albert Einstein's theories continue to fuel the daily work of physicists. From research into gravity waves to the quest for grand unification in physics, today's researchers have not finished with the legacy of the most famous and iconic physicist of the 20th Century.

  16. Approaching Bose-Einstein Condensation

    Science.gov (United States)

    Ferrari, Loris

    2011-01-01

    Bose-Einstein condensation (BEC) is discussed at the level of an advanced course of statistical thermodynamics, clarifying some formal and physical aspects that are usually not covered by the standard pedagogical literature. The non-conventional approach adopted starts by showing that the continuum limit, in certain cases, cancels out the crucial…

  17. Human needs as predictors for organizational commitment and job involvement: An exploratory empirical study

    OpenAIRE

    Park, Yang-Kyu; Lee, Chul-in; Kabst, Rüdiger

    2008-01-01

    While the literature on the determinants of organizational commitment (OC) and job involvement (JI) is vast, little has been studied about the impact of human needs. In search for the institutional stars, this study examines whether human needs can serve a predictor for both high OC and high JI. Exploratory empirical results based on quantile regressions suggest that the needs for achievement, belonging, and power are more important than others in predicting OC and JI. In addition, the basic ...

  18. An Evolutionary Genomic Approach to Identify Genes Involved in Human Birth Timing

    Science.gov (United States)

    Orabona, Guilherme; Morgan, Thomas; Haataja, Ritva; Hallman, Mikko; Puttonen, Hilkka; Menon, Ramkumar; Kuczynski, Edward; Norwitz, Errol; Snegovskikh, Victoria; Palotie, Aarno; Fellman, Vineta; DeFranco, Emily A.; Chaudhari, Bimal P.; McGregor, Tracy L.; McElroy, Jude J.; Oetjens, Matthew T.; Teramo, Kari; Borecki, Ingrid; Fay, Justin; Muglia, Louis

    2011-01-01

    Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm birth is a disorder of profound global health significance. The signals initiating parturition in humans have remained elusive, due to divergence in physiological mechanisms between humans and model organisms typically studied. Because of relatively large human head size and narrow birth canal cross-sectional area compared to other primates, we hypothesized that genes involved in parturition would display accelerated evolution along the human and/or higher primate phylogenetic lineages to decrease the length of gestation and promote delivery of a smaller fetus that transits the birth canal more readily. Further, we tested whether current variation in such accelerated genes contributes to preterm birth risk. Evidence from allometric scaling of gestational age suggests human gestation has been shortened relative to other primates. Consistent with our hypothesis, many genes involved in reproduction show human acceleration in their coding or adjacent noncoding regions. We screened >8,400 SNPs in 150 human accelerated genes in 165 Finnish preterm and 163 control mothers for association with preterm birth. In this cohort, the most significant association was in FSHR, and 8 of the 10 most significant SNPs were in this gene. Further evidence for association of a linkage disequilibrium block of SNPs in FSHR, rs11686474, rs11680730, rs12473870, and rs1247381 was found in African Americans. By considering human acceleration, we identified a novel gene that may be associated with preterm birth, FSHR. We anticipate other human accelerated genes will similarly be associated with preterm birth risk and elucidate essential pathways for human parturition. PMID:21533219

  19. BOOK REVIEW: Once Upon Einstein

    Science.gov (United States)

    Giannetto, E.

    2007-07-01

    Thibault Damour is a theoretical physicist, and a member of the French Academy of Sciences. This book is the translation, by Eric Novak, of the original French Si Einstein m'etait conté (Le Cherche Midi, 2005). It is neither a book of theoretical physics nor a biography of Einstein. It is not a book of history nor philosophy of science. In Damour's words it was written to encourage the reader to share with Einstein `those times when he understood some part of the hidden order of the universe'. It is a relatively short book, written in a very fluent style, but it deals with all the major problems and achievements of Einstein's works. Starting from special relativity, it continues with general relativity, quantum theories, unified field theory and a brief overview of the actual research related to Einstein's legacy. It is essentially a popular science book with some related exploration in history and philosophy to interpret physical theories. The most important problem discussed by Damour is the nature of time. On this subject, there is a very interesting short paragraph (pp 33--35) dedicated to the reception of the relativity idea by the great writer Marcel Proust and its counterpart within À la Recherche du Temps Perdu. A correct discussion of the implications of a relativistic time should imply the distinction of the different possible interpretations of this concept. Damour seems to conclude that only one interpretation is possible: `time does not exist', flowing of time is an illusion. One has to know that Einstein's ideas on time were related to Spinoza's perspective of a knowledge sub specie aeternitatis. However, other interpretations are possible and are related to the idea of time as an actuality. Damour speaks about the controversy between Einstein and Bergson, but Bergson is considered as a philosopher who did not understand relativity. This philosophical problem of relativistic time is indeed related to a historical problem briefly discussed by Damour

  20. Einstein's Miraculous Year

    Indian Academy of Sciences (India)

    The revolution of the earth around the sun has given us a natural unit of time, the year ... are watershed events for the human race itself, in a far more profound sense ..... the conflict was to modify Newtonian mechanics while retaining Maxwell's ...

  1. The Human Rights Context for Ethical Requirements for Involving People with Intellectual Disability in Medical Research

    Science.gov (United States)

    Iacono, T.; Carling-Jenkins, R.

    2012-01-01

    Background: The history of ethical guidelines addresses protection of human rights in the face of violations. Examples of such violations in research involving people with intellectual disabilities (ID) abound. We explore this history in an effort to understand the apparently stringent criteria for the inclusion of people with ID in research, and…

  2. Einstein boundary conditions for the 3+1 Einstein equations

    International Nuclear Information System (INIS)

    Frittelli, Simonetta; Gomez, Roberto

    2003-01-01

    In the 3+1 framework of the Einstein equations for the case of a vanishing shift vector and arbitrary lapse, we calculate explicitly the four boundary equations arising from the vanishing of the projection of the Einstein tensor along the normal to the boundary surface of the initial-boundary value problem. Such conditions take the form of evolution equations along (as opposed to across) the boundary for certain components of the extrinsic curvature and for certain space derivatives of the three-metric. We argue that, in general, such boundary conditions do not follow necessarily from the evolution equations and the initial data, but need to be imposed on the boundary values of the fundamental variables. Using the Einstein-Christoffel formulation, which is strongly hyperbolic, we show how three of the boundary equations up to linear combinations should be used to prescribe the values of some incoming characteristic fields. Additionally, we show that the fourth one imposes conditions on some outgoing fields

  3. Einstein's impact on theoretical physics

    International Nuclear Information System (INIS)

    Yang, C.N.

    1983-01-01

    There occurred in the early years of this century three conceptual revolutions that profoundly changed Man's understanding of the physical universe: the special theory of relativity (in 1905), the general theory of relativity (1915) and quantum mechanics (1925). Einstein personally was responsible for the first two of these revolutions, and influenced and helped to shape the third. But it is not about his work in these conceptual revolutions that he writes about here. Much has been written about that work already. Instead, he discusses, in general terms, Einstein's insights on the structure of theoretical physics and their relevance to the development of physics in the second half of this century. He divides the discussion into four sections which are, of course, very much related

  4. Discrete Bose-Einstein spectra

    International Nuclear Information System (INIS)

    Vlad, Valentin I.; Ionescu-Pallas, Nicholas

    2001-03-01

    The Bose-Einstein energy spectrum of a quantum gas, confined in a rigid cubic box, is shown to become discrete and strongly dependent on the box geometry (size L), temperature, T and atomic mass number, A at , in the region of small γ=A at TV 1/3 . This behavior is the consequence of the random state degeneracy in the box. Furthermore, we demonstrate that the total energy does not obey the conventional law any longer, but a new law, which depends on γ and on the quantum gas fugacity. This energy law imposes a faster decrease to zero than it is classically expected, for γ→0. The lighter the gas atoms, the higher the temperatures or the box size, for the same effects in the discrete Bose-Einstein regime. (author)

  5. Albert Einstein, Cosmos and Religion

    Science.gov (United States)

    Djokovic, V.; Grujic, P.

    2007-06-01

    We consider Einstein's attitude regarding religious as such, from both cosmological and epistemological points of view. An attempt to put it into a wider socio-historical perspective was made, with the emphasis on ethnic and religious background. It turns out that the great scientist was neither atheist nor believer in the orthodox sense and the closest labels one might stick to him in this respect would be pantheism/cosmism (ontological aspect) and agnosticism (epistemological aspect). His ideas on divine could be considered as a continuation of line traced by Philo of Alexandria, who himself followed Greek Stoics and (Neo-) Platonists and especially Baruch Spinoza. It turns out that Einstein's both scientific (rational aspects) and religious (intuitive aspects) thinking were deeply rooted in the Hellenic culture. His striving to unravel the secrets of the universe and the roots of cosmological order resembles much the ancient ideas of the role of knowledge in fathoming the divine as such, as ascribed to Gnostics.

  6. Unifying Einstein and Palatini gravities

    International Nuclear Information System (INIS)

    Amendola, Luca; Enqvist, Kari; Koivisto, Tomi

    2011-01-01

    We consider a novel class of f(R) gravity theories where the connection is related to the conformally scaled metric g μν =C(R)g μν with a scaling that depends on the scalar curvature R only. We call them C theories and show that the Einstein and Palatini gravities can be obtained as special limits. In addition, C theories include completely new physically distinct gravity theories even when f(R)=R. With nonlinear f(R), C theories interpolate and extrapolate the Einstein and Palatini cases and may avoid some of their conceptual and observational problems. We further show that C theories have a scalar-tensor formulation, which in some special cases reduces to simple Brans-Dicke-type gravity. If matter fields couple to the connection, the conservation laws in C theories are modified. The stability of perturbations about flat space is determined by a simple condition on the Lagrangian.

  7. Self Completeness of Einstein Gravity

    CERN Document Server

    Dvali, Gia

    2010-01-01

    We argue, that in Einsteinian gravity the Planck length is the shortest length of nature, and any attempt of resolving trans-Planckian physics bounces back to macroscopic distances due to black hole formation. In Einstein gravity trans-Planckian propagating quantum degrees of freedom cannot exist, instead they are equivalent to the classical black holes that are fully described by lighter infra-red degrees of freedom and give exponentially-soft contribution into the virtual processes. Based on this property we argue that pure-Einstein (super)gravity and its high-dimensional generalizations are self-complete in deep-UV, but not in standard Wilsonian sense. We suggest that certain strong-coupling limit of string theory is built-in in pure Einstein gravity, whereas the role of weakly-coupled string theory limit is to consistently couple gravity to other particle species, with their number being set by the inverse string coupling. We also discuss some speculative ideas generalizing the notion of non-Wilsonian sel...

  8. Radiation in the Einstein universe and the cosmic background

    International Nuclear Information System (INIS)

    Segal, I.E.

    1983-01-01

    It is shown that the cosmic background radiation is not at all uniquely or scientifically relatively economically indicative of a ''big bang.'' Specifically, essentially any temporally homogeneous theory in the Einstein universe is consistent with the existence of a cosmic background radiation (CBR) conforming to the Planck law; in particular, the chronometric cosmology is such. It is noted that the Einstein universe appears particularly natural as a habitat for photons by virtue of the absence of infrared divergences and of the absolute convergence of the trace for associated Gibbs-state density matrices. These features are connected with the closed character of space in the Einstein universe, and facilitate the use of the latter in modeling local phenomena, in place of Minkowski space with periodic boundary conditions or the like, with minimal loss of covariance or effect on the wave functions. In particular, the Einstein universe may be used in the analysis of the perturbation of a Planck-law spectrum due to a local nonvanishing isotropic angular momentum of the CBR, of whatever origin. The estimated distortion of the spectrum due to such a kinematically admissible effect is in very good agreement with that observed by Woody and Richards, which is opposite in direction to those earlier predicted by big-bang theories. The theoretical analysis involves a preliminary treatment of equilibria of linear quantum fields with supplementary quasilinear constraints

  9. Development and oversight of ethical health promotion quality assurance and evaluation activities involving human participants.

    Science.gov (United States)

    Sainsbury, Peter

    2015-12-01

    This paper considers the role of ethics and ethics review processes in the development of health promotion quality assurance and evaluation activities involving human participants. The Australian National Health and Medical Research Council (NHMRC) National Statement on Ethical Conduct in Human Research and associated documents provide the framework for the ethical conduct and independent review of research (including quality assurance and evaluation) involving humans in Australia. Identifying the level of risk to which participants may be exposed by participation in quality assurance and evaluation activities is essential for health promotion workers undertaking such activities. Organisations can establish processes other than review by a Human Research Ethics Committee for negligible and low risk research activities. Health promotion quality assurance and evaluation activities often involve negligible and low risk to participants. Seven triggers that indicate the need for ethics review of quality assurance and evaluation activities and a procedural checklist for developing ethical quality assurance and evaluation activities are provided. Health promotion workers should be familiar with the NHMRC's National Statement on Ethical Conduct in Human Research. When ethical considerations underpin the planning and conduct of all quality assurance and evaluation from the very beginning, the activity is the better for it, independent 'ethics approval' can mostly be secured without much trouble and workers' frustration levels are reduced. So what? Health promotion quality assurance and evaluation activities must be ethically justified. Health promotion workers should be familiar with the NHMRC's National Statement on Ethical Conduct in Human Research and should use it when developing health promotion quality assurance and evaluation activities.

  10. Possible involvement of loss of imprinting in immortalization of human fibroblasts.

    Science.gov (United States)

    Okamura, Kotaro; Ohno, Maki; Tsutsui, Takeki

    2011-04-01

    Disruption of the normal pattern of parental origin-specific gene expression is referred to as loss of imprinting (LOI), which is common in various cancers. To investigate a possible role of LOI in the early stage of human cell transformation, we studied LOI in 18 human fibroblast cell lines immortalized spontaneously, by viral oncogenes, by chemical or physical carcinogens, or by infection with a retrovirus vector encoding the human telomerase catalytic subunit, hTERT cDNA. LOI was observed in all the 18 immortal cell lines. The gene most commonly exhibiting LOI was NDN which displayed LOI in 15 of the 18 cell lines (83%). The other genes exhibiting LOI at high frequencies were PEG3 (50%), MAGE-L2 (61%) and ZNF 127 (50%). Expression of NDN that was lost in the immortal cell lines was restored by treatment with 5-aza-2'-deoxycytidine. The ratio of histone H3 lysine 9 methylation to histone H3 lysine 4 methylation of the chromatin containing the NDN promoter in the immortal WI-38VA13 cells was greater than that in the parental cells, suggesting chromatin structure-mediated regulation of NDN expression. We previously demonstrated that inactivation of the p16INK4a/pRb pathway is necessary for immortalization of human cells. Human fibroblasts in the pre-crisis phase and cells with an extended lifespan that eventually senesce, both of which have the normal p16INK4a/pRb pathway, did not show LOI at any imprinted gene examined. Although it is not clear if LOI plays a causal role in immortalization of human cells or is merely coincidental, these findings indicate a possible involvement of LOI in immortalization of human cells or a common mechanism involved in both processes.

  11. Examination of Signatures of Recent Positive Selection on Genes Involved in Human Sialic Acid Biology.

    Science.gov (United States)

    Moon, Jiyun M; Aronoff, David M; Capra, John A; Abbot, Patrick; Rokas, Antonis

    2018-03-28

    Sialic acids are nine carbon sugars ubiquitously found on the surfaces of vertebrate cells and are involved in various immune response-related processes. In humans, at least 58 genes spanning diverse functions, from biosynthesis and activation to recycling and degradation, are involved in sialic acid biology. Because of their role in immunity, sialic acid biology genes have been hypothesized to exhibit elevated rates of evolutionary change. Consistent with this hypothesis, several genes involved in sialic acid biology have experienced higher rates of non-synonymous substitutions in the human lineage than their counterparts in other great apes, perhaps in response to ancient pathogens that infected hominins millions of years ago (paleopathogens). To test whether sialic acid biology genes have also experienced more recent positive selection during the evolution of the modern human lineage, reflecting adaptation to contemporary cosmopolitan or geographically-restricted pathogens, we examined whether their protein-coding regions showed evidence of recent hard and soft selective sweeps. This examination involved the calculation of four measures that quantify changes in allele frequency spectra, extent of population differentiation, and haplotype homozygosity caused by recent hard and soft selective sweeps for 55 sialic acid biology genes using publicly available whole genome sequencing data from 1,668 humans from three ethnic groups. To disentangle evidence for selection from confounding demographic effects, we compared the observed patterns in sialic acid biology genes to simulated sequences of the same length under a model of neutral evolution that takes into account human demographic history. We found that the patterns of genetic variation of most sialic acid biology genes did not significantly deviate from neutral expectations and were not significantly different among genes belonging to different functional categories. Those few sialic acid biology genes that

  12. From the Berlin "Entwurf" Field Equations to the Einstein Tensor III: March 1916

    OpenAIRE

    Weinstein, Galina

    2012-01-01

    I discuss Albert Einstein's 1916 General Theory of Relativity. I show that in Einstein's 1916 review paper, "the Foundation of the General Theory of Relativity", he derived his November 25, 1915 field equations with an additional term on the right hand side involving the trace of the energy-momentum tensor (he posed the condition square root -g=1) using the equations he presented on November 4, 1915. Series of papers: Final paper.

  13. Einstein's Jury The Race to Test Relativity

    CERN Document Server

    Crelinsten, Jeffrey

    2006-01-01

    Einstein's Jury is the dramatic story of how astronomers in Germany, England, and America competed to test Einstein's developing theory of relativity. Weaving a rich narrative based on extensive archival research, Jeffrey Crelinsten shows how these early scientific debates shaped cultural attitudes we hold today. The book examines Einstein's theory of general relativity through the eyes of astronomers, many of whom were not convinced of the legitimacy of Einstein's startling breakthrough. These were individuals with international reputations to uphold and benefactors and shareholders to p

  14. The Routledge guidebook to Einstein's relativity

    CERN Document Server

    Trefil, James

    2015-01-01

    Albert Einstein, one of the most prolific scientists of the twentieth century, developed the theory of relativity which was crucial for the advancement of modern physics. Young Einstein identified a paradox between Newtonian Mechanics and Maxwell's equations which pointed to a flawed understanding of space and time by the scientists of the day. In Relativity, Einstein presents his findings using a minimal amount of mathematical language, but the text can still be challenging for readers who lack an extensive scientific background.The Routledge Guidebook to Einstein's Relativity expands on and

  15. Boltzmann, Einstein, Natural Law and Evolution

    International Nuclear Information System (INIS)

    Broda, E.

    1980-01-01

    Like Boltzmann, Einstein was a protagonist of atomistics. As a physicist, he has been called Boltzmann's true successor. Also in epistemology, after overcoming the positivist influence of Mach, Einstein approached Boltzmann. Any difference between Boltzmann's realism, or even materialism, and Einstein's pantheism may be merely a matter of emphasis. Yet a real difference exists in another respect. Boltzmann explained man's power of thinking and feeling, his morality and his esthetic sense, on an evolutionary, Darwinian, basis. In contrast, evolution had no role in Einstein's thought, though Darwin was accepted by him. This lack of appreciation of the importance of evolution is now attributed to socio-political factors. (author)

  16. Cinnamic Acid Is Partially Involved in Propolis Immunomodulatory Action on Human Monocytes

    Directory of Open Access Journals (Sweden)

    Bruno José Conti

    2013-01-01

    Full Text Available Propolis is a beehive product used in traditional medicine due to its biological properties. It shows a complex chemical composition including phenolics, such as cinnamic acid (Ci. The mechanisms of action of propolis have been the subject of research recently; however, the involvement of Ci on propolis activity was not investigated on immune cells. Ci effects were evaluated on human monocytes, assessing the expression of Toll-like receptors (TLRs, HLA-DR, and CD80. Cytokine production (TNF-α and IL-10 and the fungicidal activity of monocytes were evaluated as well. Data showed that Ci downregulated TLR-2, HLA-DR, and CD80 and upregulated TLR-4 expression by human monocytes. High concentrations of Ci inhibited both TNF-α and IL-10 production, whereas the same concentrations induced a higher fungicidal activity against Candida albicans. TNF-α and IL-10 production was decreased by blocking TLR-4, while the fungicidal activity of monocytes was not affected by blocking TLRs. These results suggest that Ci modulated antigen receptors, cytokine production, and the fungicidal activity of human monocytes depending on concentration, and TLR-4 may be involved in its mechanism of action. Ci seemed to be partially involved in propolis activities.

  17. Reporting of ethical protection in recent oral and maxillofacial surgery research involving human subjects.

    Science.gov (United States)

    Pitak-Arnnop, P; Sader, R; Hervé, C; Dhanuthai, K; Bertrand, J-Ch; Hemprich, A

    2009-07-01

    This retrospective observational study investigated the frequency of reporting ethical approval and informed consent in recently published oral and maxillofacial surgery (OMS) research involving human subjects. All research involving human subjects published in the International Journal of Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, British Journal of Oral and Maxillofacial Surgery, and Journal of Cranio-Maxillofacial Surgery during January to June 2005-2007 were analysed for disclosure of ethical approval by a local ethical committee and obtaining informed consent from the subjects. 534 articles were identified; ethical approval was documented in 118 (22%) and individual patient consent in 135 (25%). 355 reports (67%) did not include a statement on ethical approval or informed consent and only 74 reports (14%) disclosed statements of both. Ethical documentation in retrospective and observational studies was scant; 12% of randomised controlled trials and 38% of non-random trials did not report both of ethical protections. Most recent OMS publications involving humans failed to mention ethical review or subjects' consent. Authors must adhere to the international research ethics guidelines and journal instructions, while editors should play a gatekeeper role to protect research participants, uphold scientific integrity and maintain public trust in the experimental process and OMS profession.

  18. Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation.

    Science.gov (United States)

    Alkozi, Hanan Awad; Perez de Lara, María J; Pintor, Jesús

    2017-09-01

    Melatonin is a substance synthesized in the pineal gland as well as in other organs. This substance is involved in many ocular functions, giving its synthesis in numerous eye structures. Melatonin is synthesized from serotonin through two enzymes, the first limiting step into the synthesis of melatonin being aralkylamine N-acetyltransferase (AANAT). In this current study, AANAT phosphorylation after the activation of TRPV4 was studied using human non-pigmented epithelial ciliary body cells. Firstly, it was necessary to determine the adequate time and dose of the TRPV4 agonist GSK1016790A to reach the maximal phosphorylation of AANAT. An increase of 72% was observed after 5 min incubation with 10 nM GSK (**p melatonin synthesis. The involvement of a TRPV4 channel in melatonin synthesis was verified by antagonist and siRNA studies as a previous step to studying intracellular signalling. Studies performed on the second messengers involved in GSK induced AANAT phosphorylation were carried out by inhibiting several pathways. In conclusion, the activation of calmodulin and calmodulin-dependent protein kinase II was confirmed, as shown by the cascade seen in AANAT phosphorylation (***p melatonin levels. In conclusion, the activation of a TRPV4 present in human ciliary body epithelial cells produced an increase in AANAT phosphorylation and a further melatonin increase by a mechanism in which Ca-calmodulin and the calmodulin-dependent protein kinase II are involved. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas

    Directory of Open Access Journals (Sweden)

    London Leslie

    2010-08-01

    Full Text Available Abstract The controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter.

  20. The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas.

    Science.gov (United States)

    London, Leslie; Coggon, David; Moretto, Angelo; Westerholm, Peter; Wilks, Martin F; Colosio, Claudio

    2010-08-18

    The controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a) a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b) an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c) application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter.

  1. The ethics of human volunteer studies involving experimental exposure to pesticides: unanswered dilemmas

    Science.gov (United States)

    2010-01-01

    The controversy about the use of data from human volunteer studies involving experimental exposure to pesticides as part of regulatory risk assessment has been widely discussed, but the complex and interrelated scientific and ethical issues remain largely unresolved. This discussion paper, generated by authors who comprised a workgroup of the ICOH Scientific Committee on Rural Health, reviews the use of human experimental studies in regulatory risk assessment for pesticides with a view to advancing the debate as to when, if ever, such studies might be ethically justifiable. The discussion is based on three elements: (a) a review of discussion papers on the topic of human testing of pesticides and the positions adopted by regulatory agencies in developed countries; (b) an analysis of published and unpublished studies involving human testing with pesticides, both in the peer-reviewed literature and in the JMPR database; and (c) application of an ethical analysis to the problem. The paper identifies areas of agreement which include general principles that may provide a starting point on which to base criteria for judgements as to the ethical acceptability of such studies. However, the paper also highlights ongoing unresolved differences of opinion inherent in ethical analysis of contentious issues, which we propose should form a starting point for further debate and the development of guidelines to achieve better resolution of this matter. PMID:20718963

  2. Phosphorylation of human INO80 is involved in DNA damage tolerance

    International Nuclear Information System (INIS)

    Kato, Dai; Waki, Mayumi; Umezawa, Masaki; Aoki, Yuka; Utsugi, Takahiko; Ohtsu, Masaya; Murakami, Yasufumi

    2012-01-01

    Highlights: ► Depletion of hINO80 significantly reduced PCNA ubiquitination. ► Depletion of hINO80 significantly reduced nuclear dots intensity of RAD18 after UV irradiation. ► Western blot analyses showed phosphorylated hINO80 C-terminus. ► Overexpression of phosphorylation mutant hINO80 reduced PCNA ubiquitination. -- Abstract: Double strand breaks (DSBs) are the most serious type of DNA damage. DSBs can be generated directly by exposure to ionizing radiation or indirectly by replication fork collapse. The DNA damage tolerance pathway, which is conserved from bacteria to humans, prevents this collapse by overcoming replication blockages. The INO80 chromatin remodeling complex plays an important role in the DNA damage response. The yeast INO80 complex participates in the DNA damage tolerance pathway. The mechanisms regulating yINO80 complex are not fully understood, but yeast INO80 complex are necessary for efficient proliferating cell nuclear antigen (PCNA) ubiquitination and for recruitment of Rad18 to replication forks. In contrast, the function of the mammalian INO80 complex in DNA damage tolerance is less clear. Here, we show that human INO80 was necessary for PCNA ubiquitination and recruitment of Rad18 to DNA damage sites. Moreover, the C-terminal region of human INO80 was phosphorylated, and overexpression of a phosphorylation-deficient mutant of human INO80 resulted in decreased ubiquitination of PCNA during DNA replication. These results suggest that the human INO80 complex, like the yeast complex, was involved in the DNA damage tolerance pathway and that phosphorylation of human INO80 was involved in the DNA damage tolerance pathway. These findings provide new insights into the DNA damage tolerance pathway in mammalian cells.

  3. Task types and error types involved in the human-related unplanned reactor trip events

    International Nuclear Information System (INIS)

    Kim, Jae Whan; Park, Jin Kyun

    2008-01-01

    In this paper, the contribution of task types and error types involved in the human-related unplanned reactor trip events that have occurred between 1986 and 2006 in Korean nuclear power plants are analysed in order to establish a strategy for reducing the human-related unplanned reactor trips. Classification systems for the task types, error modes, and cognitive functions are developed or adopted from the currently available taxonomies, and the relevant information is extracted from the event reports or judged on the basis of an event description. According to the analyses from this study, the contributions of the task types are as follows: corrective maintenance (25.7%), planned maintenance (22.8%), planned operation (19.8%), periodic preventive maintenance (14.9%), response to a transient (9.9%), and design/manufacturing/installation (6.9%). According to the analysis of the error modes, error modes such as control failure (22.2%), wrong object (18.5%), omission (14.8%), wrong action (11.1%), and inadequate (8.3%) take up about 75% of the total unplanned trip events. The analysis of the cognitive functions involved in the events indicated that the planning function had the highest contribution (46.7%) to the human actions leading to unplanned reactor trips. This analysis concludes that in order to significantly reduce human-induced or human-related unplanned reactor trips, an aide system (in support of maintenance personnel) for evaluating possible (negative) impacts of planned actions or erroneous actions as well as an appropriate human error prediction technique, should be developed

  4. Task types and error types involved in the human-related unplanned reactor trip events

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Whan; Park, Jin Kyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-12-15

    In this paper, the contribution of task types and error types involved in the human-related unplanned reactor trip events that have occurred between 1986 and 2006 in Korean nuclear power plants are analysed in order to establish a strategy for reducing the human-related unplanned reactor trips. Classification systems for the task types, error modes, and cognitive functions are developed or adopted from the currently available taxonomies, and the relevant information is extracted from the event reports or judged on the basis of an event description. According to the analyses from this study, the contributions of the task types are as follows: corrective maintenance (25.7%), planned maintenance (22.8%), planned operation (19.8%), periodic preventive maintenance (14.9%), response to a transient (9.9%), and design/manufacturing/installation (6.9%). According to the analysis of the error modes, error modes such as control failure (22.2%), wrong object (18.5%), omission (14.8%), wrong action (11.1%), and inadequate (8.3%) take up about 75% of the total unplanned trip events. The analysis of the cognitive functions involved in the events indicated that the planning function had the highest contribution (46.7%) to the human actions leading to unplanned reactor trips. This analysis concludes that in order to significantly reduce human-induced or human-related unplanned reactor trips, an aide system (in support of maintenance personnel) for evaluating possible (negative) impacts of planned actions or erroneous actions as well as an appropriate human error prediction technique, should be developed.

  5. Beyond Einstein: From the Big Bang to Black Holes

    Science.gov (United States)

    2005-01-01

    How did the Universe begin? Does time have a beginning and an end? Does space have edges? The questions are clear and simple. They are as old as human curiosity. But the answers have always seemed beyond the reach of science. Until now. In their attempts to understand how space, time, and matter are connected, Einstein and his successors made three predictions. First, space is expanding from a Big Bang; second, space and time can tie themselves into contorted knots called black holes where time actually comes to a halt; third, space itself contains some kind of energy that is pull- ing the Universe apart. Each of these three predictions seemed so fantastic when it was made that everyone, including Einstein himself, regarded them as unlikely. Incredibly, all three have turned out to be true. Yet Einstein's legacy is one of deep mystery, because his theories are silent on three questions raised by his fantastic predictions: (1) What powered the Big Bang? (2) What happens to space, time, and matter at the edge of a black hole? (3) What is the mysterious dark energy pulling the Universe apart? The answers to these questions-which lie at the crux of where our current theories fail us-will lead to a profound, new understanding of the nature of time and space. To find answers, however, we must venture beyond Einstein. The answers require new theories, such as the inflationary Universe and new insights in high-energy particle theory. Like Einstein s theories, these make fantastic predictions that seem hard to believe: unseen dimensions and entire universes beyond our own. We must find facts to confront and guide these new theories. Powerful new technologies now make this possible. And NASA and its partners are developing an armada of space-based observatories to chart the path to discovery. Here is where the Beyond Einstein story begins. By exploring the three questions that are Einstein s legacy, we begin the next revolution in understanding our Universe. We plot our way

  6. Einstein and the quantum theory

    International Nuclear Information System (INIS)

    Pais, A.

    1979-01-01

    The following topics are discussed: The light-quantum hypothesis and its gradual evolution into the photon concept. Early history of the photoelectric effect. The theoretical and experimental reasons why the resistance to the photon was stronger and more protracted than for any other particle proposed to date. Einstein's position regarding the Bohr--Kramers--Slater suggestion, the last bastion of resistance to the photon. Einstein's analysis of fluctuations around thermal equilibrium and his proposal of a duality between particles and waves, in 1909 for electromagnetic radiation (the first time this duality was ever stated) and in January 1925 for matter (prior to quantum mechanics and for reasons independent of those given earlier by de Broglie). His demonstration that long-known specific heat anomalies are quantum effects. His role in the evolution of the third law of thermodynamics. His new derivation of Planck's law in 1917 which also marks the beginning of his concern with the failure of classical causality. His role as one of the founders of quantum statistics and his discovery of the first example of a phase transition derived by using purely statistical methods. His position as a critic of quantum mechanics. Initial doubts on the consistency of quantum mechanics (1926--1930). His view maintained from 1930 until the end of his life: quantum mechanics is logically consistent and quite successful but it is incomplete. His attitude toward success. His criterion of objective reality. Differences in the roles relativity and quantum theory played in Einstein's life. His vision regarding quantum theory in the context of a unified field theory. His last autobiographical sketch, written a few months before his death, concluding with a statement about the quantum theory, a subject to which (by his own account) he had given more thought than even to general relativity

  7. Albert Einstein:. Opportunity and Perception

    Science.gov (United States)

    Yang, Chen Ning

    2013-05-01

    The year 1905 has been called Albert Einstein's "Annus Mirabilis." It was during that year that he caused revolutionary changes in man's primordial concepts about the physical world: space, time, energy, light and matter. How could a 26-year-old clerk, previously unknown, cause such profound conceptual changes, and thereby open the door to the era of modern scientific technological world? No one, of course, can answer that question. But one can, perhaps, analyze some factors that were essential to his stepping into such a historic role...

  8. Ultraviolet divergences of Einstein gravity

    International Nuclear Information System (INIS)

    Goroff, M.H.

    1986-01-01

    The author discuss a two-loop calculation showing that the S matrix of Einstein's theory of gravity contains nonrenormalizable ultraviolet divergences in four dimension. The author discusses the calculation in both background field and normal field theory. The author describes a new method for dealing with ghost fields in gauge theories by combining them with suitable extensions of the gauge fields in higher dimensions. The author shows how using subtracted integrals in the calculation of higher loop graphs simplifies the calculation in the background field method by eliminating the need for mixed counterterms. Finally, the author makes some remarks about the implications of the result for supergravity theories

  9. Albert Einstein, un hombre universal

    OpenAIRE

    Arias Arroyo, Gladys

    2014-01-01

    Albert Einstein, famoso por su teoría de la relatividad, que cambió toda las concepciones previas sobre la gravitación, el cosmos, la geometría y en general toda la ciencia moderna. Además de ser un genio científico, fue un gran humanista, partidario de la convivencia pacífica entre los pueblos, gran defensor de la libertad individual y del progreso. A pesar de que en su infancia y juventud tropezó con más inconvenientes que ventajas, tuvo la gran habilidad de conectar sus innegables dotes na...

  10. Einstein on Race and Racism

    CERN Document Server

    Jerome, Fred

    2005-01-01

    Nearly fifty years after his death, Albert Einstein remains one of America's foremost cultural icons. A thicket of materials, ranging from scholarly to popular, have been written, compiled, produced, and published about his life and his teachings. Among the ocean of Einsteinia-scientific monographs, biographies, anthologies, bibliographies, calendars, postcards, posters, and Hollywood films-however, there is a peculiar void when it comes to the connection that the brilliant scientist had with the African American community. Nowhere is there any mention of his close relationship with Pa

  11. Genes involved in immunity and apoptosis are associated with human presbycusis based on microarray analysis.

    Science.gov (United States)

    Dong, Yang; Li, Ming; Liu, Puzhao; Song, Haiyan; Zhao, Yuping; Shi, Jianrong

    2014-06-01

    Genes involved in immunity and apoptosis were associated with human presbycusis. CCR3 and GILZ played an important role in the pathogenesis of presbycusis, probably through regulating chemokine receptor, T-cell apoptosis, or T-cell activation pathways. To identify genes associated with human presbycusis and explore the molecular mechanism of presbycusis. Hearing function was tested by pure-tone audiometry. Microarray analysis was performed to identify presbycusis-correlated genes by Illumina Human-6 BeadChip using the peripheral blood samples of subjects. To identify biological process categories and pathways associated with presbycusis-correlated genes, bioinformatics analysis was carried out by Gene Ontology Tree Machine (GOTM) and database for annotation, visualization, and integrated discovery (DAVID). Quantitative RT-PCR (qRT-PCR) was used to validate the microarray data. Microarray analysis identified 469 up-regulated genes and 323 down-regulated genes. Both the dominant biological processes by Gene Ontology (GO) analysis and the enriched pathways by Kyoto encyclopedia of genes and genomes (KEGG) and BIOCARTA showed that genes involved in immunity and apoptosis were associated with presbycusis. In addition, CCR3, GILZ, CXCL10, and CX3CR1 genes showed consistent difference between groups for both the gene chip and qRT-PCR data. The differences of CCR3 and GILZ between presbycusis patients and controls were statistically significant (p < 0.05).

  12. The landscape of human genes involved in the immune response to parasitic worms

    Directory of Open Access Journals (Sweden)

    Fumagalli Matteo

    2010-08-01

    Full Text Available Abstract Background More than 2 billion individuals worldwide suffer from helminth infections. The highest parasite burdens occur in children and helminth infection during pregnancy is a risk factor for preterm delivery and reduced birth weight. Therefore, helminth infections can be regarded as a strong selective pressure. Results Here we propose that candidate susceptibility genes for parasitic worm infections can be identified by searching for SNPs that display a strong correlation with the diversity of helminth species/genera transmitted in different geographic areas. By a genome-wide search we identified 3478 variants that correlate with helminth diversity. These SNPs map to 810 distinct human genes including loci involved in regulatory T cell function and in macrophage activation, as well as leukocyte integrins and co-inhibitory molecules. Analysis of functional relationships among these genes identified complex interaction networks centred around Th2 cytokines. Finally, several genes carrying candidate targets for helminth-driven selective pressure also harbour susceptibility alleles for asthma/allergy or are involved in airway hyper-responsiveness, therefore expanding the known parallelism between these conditions and parasitic infections. Conclusions Our data provide a landscape of human genes that modulate susceptibility to helminths and indicate parasitic worms as one of the major selective forces in humans.

  13. Correspondence passed between Einstein and Schroedinger

    International Nuclear Information System (INIS)

    Balibar, F.

    1992-01-01

    The main points of the 26 year long correspondence between Einstein and Schroedinger are reviewed: from the de Broglie thesis and the Bose-Einstein statistics to the Schroedinger equation (1925-1926); from the EPR paradox to the cat parable (1935); a complete collaboration on unitary theories

  14. New details emerge from the Einstein files

    CERN Multimedia

    Overbye, D

    2002-01-01

    For many years the FBI spied on Einstein. New details of this surveilance are emerging in "The Einstein File: J. Edgar Hoover's Secret War Against the World's Most Famous Scientist," by Fred Jerome, who sued the government with the help of the Public Citizen Litigation Group to obtain a less censored version of the file (1 page).

  15. Albert Einstein and 20th century's physics

    International Nuclear Information System (INIS)

    Zajac, R.

    1979-01-01

    Albert Einstein's teaching and his three fundamental works are discussed dealing with the molecular theory of heat applied to the motion of suspended particles in liquids at rest, the photoelectric effect, and the theory of relativity. Albert Einstein's impact on contemporary physics is evaluated. (J.P.)

  16. The Einstein-Podolsky-Rosen paradox

    International Nuclear Information System (INIS)

    Roy, S.M.

    1980-01-01

    The celebrated arguments of Einstein, Podolsky and Rosen claiming that quantum mechanics cannot be a complete theory are reviewed. Recent research climaxed by Bell's theorem shows that Einstein's locality or ''no telepathy'' postulate conflicts with quantum theory. It adds a new dimension to the paradox by catapulting the problem from the domain of metaphysics into that of experimental physics. (auth.)

  17. Albert Einstein and the relativity theory

    International Nuclear Information System (INIS)

    Pavlickova, E.

    1975-01-01

    A bibliography is presented of Albert Einstein's works, listing his correspondence, biographical literature, articles on A. Einstein published in Czech journals, principal relativity theory monographs and popular, historical and philosophical publications. The bibliographical records are listed alphabetically. Most references give the abbreviations of libraries where the publications are available. (J.P.)

  18. Einstein in love a scientific romance

    CERN Document Server

    Overbye, Dennis

    2000-01-01

    At its height, Einstein's marriage to Mileva was an extraordinary one - a colleague and often fierce adversary, Mileva was brilliantly matched with the scientific genius. Dennis Overbye seeks to present this scientific romance in a vivid light, telling the private story of the young Einstein.

  19. Books on Einstein--Collectors' Delight

    Science.gov (United States)

    Khoon, Koh Aik; Jalal, Azman; Abd-Shukor, R.; Yatim, Baharudin; Talib, Ibrahim Abu; Daud, Abdul Razak; Samat, Supian

    2009-01-01

    A survey of thirteen books on Einstein is presented. Its gives an idea on how much is written about the man and how frequent are the publications. The year 2005 saw the most publications. It is the centenary for the Miraculous Year. Interestingly some books can just sustain their readers' interest with just words. Einstein comes alive with the…

  20. What Einstein Can Teach Us about Education

    Science.gov (United States)

    Hayes, Denis

    2007-01-01

    People are more likely to associate Einstein with complex scientific theories and mathematical calculations than with education theory. In fact, Einstein's own experiences of schooling and his reflections on the meaning of life and the significance of education are profound and oddly relevant to the situation that pertains in England today. It is…

  1. Einstein as a Missionary of Science

    Science.gov (United States)

    Renn, Jürgen

    2013-01-01

    The paper reviews Einstein's engagement as a mediator and popularizer of science. It discusses the formative role of popular scientific literature for the young Einstein, showing that not only his broad scientific outlook but also his internationalist political views were shaped by these readings. Then, on the basis of recent detailed…

  2. A note on Einstein-Sasaki metrics in D ≥ 7

    International Nuclear Information System (INIS)

    Chen, W; Lue, H; Pope, C N; Vazquez-Poritz, J F

    2005-01-01

    In this paper, we obtain new non-singular Einstein-Sasaki spaces in dimensions D ≥ 7. The local construction involves taking a circle bundle over a (D - 1)-dimensional Einstein-Kaehler metric that is itself constructed as a complex line bundle over a product of Einstein-Kaehler spaces. In general, the resulting Einstein-Sasaki spaces are singular, but if parameters in the local solutions satisfy appropriate rationality conditions, the metrics extend smoothly onto complete and non-singular compact manifolds. The seven-dimensional space, whose base is a complex line bundle over S 2 x S 2 , is discussed in detail since it has relevance in terms of the AdS/CFT correspondence

  3. The Sky at Einstein's Feet

    CERN Document Server

    Keel, William C

    2006-01-01

    The insights of relativity have illuminated a century of astronomical discovery, often going beyond the phenomena that Einstein lived to see. This book shows, in nonmathematical ways, how deeply these ways of viewing the Universe have informed our interpretations of it, and how many of the amazing discoveries of these decades have made sense only as part of Einstein's universe. The author brings together the ways in which we see the bizarre effects of relativity played out on a cosmic scale. None of this is particularly new to practicing astronomers, but much has yet to be seen outside technical journals. The presentation avoids mathematics (except for the most famous equation in all of physics!), and is designed to be accessible to the interested public. Gravitational lenses, the visible effects of light-travel delays, the search for black holes, the ways relativity in atomic nuclei makes stars shine, are all treated. In many cases, some of the principals are still alive and provided new commentary on the di...

  4. Albert Einstein, cosmos and religion

    Directory of Open Access Journals (Sweden)

    Doković V.

    2007-01-01

    Full Text Available We consider Einstein's attitude regarding religious as such, from both cosmological and epistemological points of view. An attempt to put it into a wider socio-historical perspective was made, with the emphasis on ethnic and religious background. It turns out that the great scientist was neither atheist nor believer in the orthodox sense and the closest labels one might stick to him in this respect would be pantheism/cosmism (ontological aspect and agnosticism (episte­mological aspect. His ideas on divine could be considered as a continuation of line traced by Philo of Alexandria, who himself followed Greek Stoics and (Neo- Platonists and especially Baruch Spinoza. It turns out that Einstein's both scientific (rational aspects and religious (intuitive aspects thinking were deeply rooted in the Hellenic culture. His striving to unravel the secrets of the universe and the roots of cosmological order resembles much the ancient ideas of the role of knowledge in fathoming the divine as such, as ascribed to Gnostics. .

  5. Einstein a hundred years of relativity

    CERN Document Server

    Robinson, Andrew

    2015-01-01

    "The eternal mystery of the world is its comprehensibility … The fact that it is comprehensible is a miracle." --Albert Einstein, 1936 Albert Einstein's universal appeal is only partially explained by his brilliant work in physics, as Andrew Robinson demonstrates in this authoritative, accessible, and richly illustrated biography. The main narrative is enriched by twelve essays by well-known scientists, scholars, and artists, including three Nobel Laureates. The book presents clearly the beautiful simplicity at the heart of Einstein's greatest discoveries, and explains how his ideas have continued to influence scientific developments such as lasers, the theory of the big bang, and "theories of everything." Einstein's life and activities outside of science are also considered, including his encounters with famous contemporaries such as Chaplin, Roosevelt, and Tagore, his love of music, and his troubled family life. The book recognizes that Einstein's striking originality was expressed in many ways, from hi...

  6. Astrophysical observations: lensing and eclipsing Einstein's theories.

    Science.gov (United States)

    Bennett, Charles L

    2005-02-11

    Albert Einstein postulated the equivalence of energy and mass, developed the theory of special relativity, explained the photoelectric effect, and described Brownian motion in five papers, all published in 1905, 100 years ago. With these papers, Einstein provided the framework for understanding modern astrophysical phenomena. Conversely, astrophysical observations provide one of the most effective means for testing Einstein's theories. Here, I review astrophysical advances precipitated by Einstein's insights, including gravitational redshifts, gravitational lensing, gravitational waves, the Lense-Thirring effect, and modern cosmology. A complete understanding of cosmology, from the earliest moments to the ultimate fate of the universe, will require developments in physics beyond Einstein, to a unified theory of gravity and quantum physics.

  7. A student's guide to Einstein's major papers

    CERN Document Server

    Kennedy, Robert E

    2012-01-01

    Our understanding of the physical universe underwent a revolution in the early twentieth century - evolving from the classical physics of Newton, Galileo, and Maxwell to the modern physics of relativity and quantum mechanics. The dominant figure in this revolutionary change was Albert Einstein. In a single year, 1905, Einstein produced breakthrough works in three areas of physics: on the size and the effects of atoms; on the quantization of the electromagnetic field; and on the special theory of relativity. In 1916 he produced a fourth breakthrough work, the general theory of relativity. A Student's Guide to Einstein's Major Papers focuses on Einstein's contributions, setting his major works into their historical context, and then takes the reader through the details of each paper, including the mathematics. This book helps the reader appreciate the simplicity and insightfulness of Einstein's ideas and how revolutionary his work was, and locate it in the evolution of scientific thought begun by the ancient...

  8. Einstein Ring in Distant Universe

    Science.gov (United States)

    2005-06-01

    Using ESO's Very Large Telescope, Rémi Cabanac and his European colleagues have discovered an amazing cosmic mirage, known to scientists as an Einstein Ring. This cosmic mirage, dubbed FOR J0332-3557, is seen towards the southern constellation Fornax (the Furnace), and is remarkable on at least two counts. First, it is a bright, almost complete Einstein ring. Second, it is the farthest ever found. ESO PR Photo 20a/05 ESO PR Photo 20a/05 Deep Image of a Region in Fornax (FORS/VLT) [Preview - JPEG: 400 x 434 pix - 60k] [Normal - JPEG: 800 x 867 pix - 276k] [Full Res - JPEG: 1859 x 2015 pix - 3.8M] ESO PR Photo 20b/05 ESO PR Photo 20b/05 Zoom-in on the Newly Found Einstein Ring (FORS/VLT) [Preview - JPEG: 400 x 575 pix - 168k] [Normal - JPEG: 630 x 906 pix - 880k] Caption: ESO PR Photo 20a/05 is a composite image taken in two bands (B and R) with VLT/FORS1 of a small portion of the sky (field-of-view 7x7' or 1/15th of the area of the full moon). The faintest object seen in the image has a magnitude 26, that is, it is 100 million times fainter than what can be observed with the unaided eye. The bright elliptical galaxy on the lower-left quadrant is a dwarf galaxy part of a large nearby cluster in the Fornax constellation. As for all deep images of the sky, this field shows a variety of objects, the brightest ponctual sources being stars from our Galaxy. By far the field is dominated by thousands of faint background galaxies the colours of which are related to the age of their dominant stellar population, their dust content and their distance. The newly found Einstein ring is visible in the top right part of the image. ESO PR Photo 20b/05 zooms-in on the position of the newly found cosmic mirage. ESO PR Photo 20c/05 ESO PR Photo 20c/05 Einstein Ring in Distant Universe (FORS/VLT) [Preview - JPEG: 400 x 584 pix - 104k] [Normal - JPEG: 800 x 1168 pix - 292k] [Full Res - JPEG: 1502 x 2192 pix - 684k] Caption of ESO PR Photo 20c/05: The left image is magnified and centred

  9. Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

    International Nuclear Information System (INIS)

    Straka, Elisabeth; Ellinger, Isabella; Balthasar, Christina; Scheinast, Matthias; Schatz, Jasmin; Szattler, Tamara; Bleichert, Sonja; Saleh, Leila; Knöfler, Martin; Zeisler, Harald; Hengstschläger, Markus; Rosner, Margit; Salzer, Hans; Gundacker, Claudia

    2016-01-01

    Highlights: • It is known that MeHg is able to pass the placenta and to affect fetal brain development. • Uptake and efflux transporters were examined in human primary trophoblast cells and BeWo cells. • Involvement in mercury transfer was assessed by measurement of cellular mercury content upon siRNA mediated gene knockdown. • Localization of transporters was determined by immunofluorescence microscopy. • LAT1 and rBAT at the apical membrane of the syncytiotrophoblast (STB) are involved in MeHg uptake. • MRP1 located at basal membrane of STB mediates mercury efflux. - Abstract: Background: The capacity of the human placenta to handle exogenous stressors is poorly understood. The heavy metal mercury is well-known to pass the placenta and to affect brain development. An active transport across the placenta has been assumed. The underlying mechanisms however are virtually unknown. Objectives: Uptake and efflux transporters (17 candidate proteins) assumed to play a key role in placental mercury transfer were examined for expression, localization and function in human primary trophoblast cells and the trophoblast-derived choriocarcinoma cell line BeWo. Methods: To prove involvement of the transporters, we used small interfering RNA (siRNA) and exposed cells to methylmercury (MeHg). Total mercury contents of cells were analyzed by Cold vapor-atomic fluorescence spectrometry (CV-AFS). Localization of the proteins in human term placenta sections was determined via immunofluorescence microscopy. Results: We found the amino acid transporter subunits L-type amino acid transporter (LAT)1 and rBAT (related to b 0,+ type amino acid transporter) as well as the efflux transporter multidrug resistance associated protein (MRP)1 to be involved in mercury kinetics of trophoblast cells (t-test P < 0.05). Conclusion: The amino acid transporters located at the apical side of the syncytiotrophoblast (STB) manage uptake of MeHg. Mercury conjugated to glutathione (GSH) is

  10. Cellular and molecular effect of MEHP Involving LXRα in human fetal testis and ovary.

    Science.gov (United States)

    Muczynski, Vincent; Lecureuil, Charlotte; Messiaen, Sébastien; Guerquin, Marie-Justine; N'tumba-Byn, Thierry; Moison, Delphine; Hodroj, Wassim; Benjelloun, Hinde; Baijer, Jan; Livera, Gabriel; Frydman, René; Benachi, Alexandra; Habert, René; Rouiller-Fabre, Virginie

    2012-01-01

    Phthalates have been shown to have reprotoxic effects in rodents and human during fetal life. Previous studies indicate that some members of the nuclear receptor (NR) superfamilly potentially mediate phthalate effects. This study aimed to assess if expression of these nuclear receptors are modulated in the response to MEHP exposure on the human fetal gonads in vitro. Testes and ovaries from 7 to 12 gestational weeks human fetuses were exposed to 10(-4)M MEHP for 72 h in vitro. Transcriptional level of NRs and of downstream genes was then investigated using TLDA (TaqMan Low Density Array) and qPCR approaches. To determine whether somatic or germ cells of the testis are involved in the response to MEHP exposure, we developed a highly efficient cytometric germ cell sorting approach. In vitro exposure of fetal testes and ovaries to MEHP up-regulated the expression of LXRα, SREBP members and of downstream genes involved in the lipid and cholesterol synthesis in the whole gonad. In sorted testicular cells, this effect is only observable in somatic cells but not in the gonocytes. Moreover, the germ cell loss induced by MEHP exposure, that we previously described, is restricted to the male gonad as oogonia density is not affected in vitro. We evidenced for the first time that phthalate increases the levels of mRNA for LXRα, and SREBP members potentially deregulating lipids/cholesterol synthesis in human fetal gonads. Interestingly, this novel effect is observable in both male and female whereas the germ cell apoptosis is restricted to the male gonad. Furthermore, we presented here a novel and potentially very useful flow cytometric cell sorting method to analyse molecular changes in germ cells versus somatic cells.

  11. Cellular and molecular effect of MEHP Involving LXRα in human fetal testis and ovary.

    Directory of Open Access Journals (Sweden)

    Vincent Muczynski

    Full Text Available Phthalates have been shown to have reprotoxic effects in rodents and human during fetal life. Previous studies indicate that some members of the nuclear receptor (NR superfamilly potentially mediate phthalate effects. This study aimed to assess if expression of these nuclear receptors are modulated in the response to MEHP exposure on the human fetal gonads in vitro.Testes and ovaries from 7 to 12 gestational weeks human fetuses were exposed to 10(-4M MEHP for 72 h in vitro. Transcriptional level of NRs and of downstream genes was then investigated using TLDA (TaqMan Low Density Array and qPCR approaches. To determine whether somatic or germ cells of the testis are involved in the response to MEHP exposure, we developed a highly efficient cytometric germ cell sorting approach. In vitro exposure of fetal testes and ovaries to MEHP up-regulated the expression of LXRα, SREBP members and of downstream genes involved in the lipid and cholesterol synthesis in the whole gonad. In sorted testicular cells, this effect is only observable in somatic cells but not in the gonocytes. Moreover, the germ cell loss induced by MEHP exposure, that we previously described, is restricted to the male gonad as oogonia density is not affected in vitro.We evidenced for the first time that phthalate increases the levels of mRNA for LXRα, and SREBP members potentially deregulating lipids/cholesterol synthesis in human fetal gonads. Interestingly, this novel effect is observable in both male and female whereas the germ cell apoptosis is restricted to the male gonad. Furthermore, we presented here a novel and potentially very useful flow cytometric cell sorting method to analyse molecular changes in germ cells versus somatic cells.

  12. Human Trafficking and Sexual Servitude: Organised Crime’s Involvement in Australia

    Directory of Open Access Journals (Sweden)

    Mark Langhorn

    2018-03-01

    Full Text Available This study examined the context of organised crime groups that traffic in people for the Australian sex industry. It is a qualitative study of twenty-one cases of human trafficking. The study found that criminal networks preyed on vulnerable females from countries such as Thailand, South Korea, and China. Victims were deceptively recruited with the cost of their travel to Australia held against them as a highly inflated debt. As a result, they find themselves forced into sex work to repay the debt. This study examined the attributes of the organised crime syndicates involved in the people trafficking and discussed the context in which they operate in Australia. The study used the Sleipnir framework to analyse organised crime groups and it is recommended that the Sleipnir model is integrated into future law enforcement activities in respect of human trafficking. The introduction of a standardised data and statistical collection tool in respect of human trafficking would provide law enforcement and intelligence agencies with a conceptual framework and a greater comprehensive description of human trafficking.

  13. Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes

    International Nuclear Information System (INIS)

    Zhang, H.; Wang, J.C.; Liu, L.F.

    1988-01-01

    Treatment of HeLa cells with a DNA topoisomerase I-specific inhibitor, camptothecin, results in rapid cessation of the synthesis of the 45S rRNA precursor. The inhibition of rRNA synthesis is reversible following drug removal and correlates with the presence of camptothecin-trapped topoisomerase I-DNA abortive complexes, which can be detected as topoisomerase I-linked DNA breaks upon lysis with sodium dodecyl sulfate. These breaks were found to be concentrated within the transcribed region of human rRNA genes. No such sites can be detected in the inactive human rRNA genes in mouse-human hybrid cells, suggesting a preferential association of topoisomerase I with actively transcribed genes. The distribution of RNA polymerase molecules along the transcription unit of human rRNA genes in camptothecin-treated HeLa cells, as assayed by nuclear run-on transcription, shows a graded decrease of the RNA polymerase density toward the 3' end of the transcription unit; the density is minimally affected near the 5' start of the transcription unit. These results suggest that DNA topoisomerase I is normally involved in the elongation step of transcription, especially when the transcripts are long, and that camptothecin interferes with this role

  14. Characterization of Staphylococcus aureus strains involved in human and bovine mastitis.

    Science.gov (United States)

    Delgado, Susana; García, Pilar; Fernández, Leonides; Jiménez, Esther; Rodríguez-Baños, Mercedes; del Campo, Rosa; Rodríguez, Juan M

    2011-07-01

    Staphylococcus aureus is one of the main etiological agents of mastitis in different mammalian species. At present, it is unknown whether strains isolated from human mastitis cases share phenotypic properties and genetic background with those obtained from animal mastitis cases. Therefore, the objective of this study was to characterize S. aureus strains isolated from women with lactational mastitis and to compare them with the strains responsible for bovine mastitis and noninfectious strains. All the strains were genotyped by both pulsed field gel electrophoresis and multilocus sequence typing and submitted to a characterization scheme that included diverse assays related to pathogenic potential and antibiotic resistance. Apart from siderophore production, no significant association was observed between the strains from bovine and human mastitis. Statistical differences between human- and bovine-mastitis-associated strains were detected for some traits and virulence determinants, such as the presence of prophages and cna and hlb genes, which were more frequently found within the bovine group. On the contrary, resistance to penicillin was significantly higher among strains isolated from human lactational mastitis, probably related to the common presence of the blaZ gene. A high genetic diversity was found among the strains involved in mastitis in breastfeeding women. © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  15. Einstein-Yang-Mills from pure Yang-Mills amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Nandan, Dhritiman; Plefka, Jan [Institut für Physik and IRIS Adlershof, Humboldt-Universität zu Berlin,Zum Großen Windkanal 6, D-12489 Berlin (Germany); Schlotterer, Oliver [Max-Planck-Institut für Gravitationsphysik, Albert-Einstein-Institut,Am Mühlenberg 1, D-14476 Potsdam (Germany); Wen, Congkao [I.N.F.N. Sezione di Roma Tor Vergata,Via della Ricerca Scientifica, 00133 Roma (Italy)

    2016-10-14

    We present new relations for scattering amplitudes of color ordered gluons and gravitons in Einstein-Yang-Mills theory. Tree-level amplitudes of arbitrary multiplicities and polarizations involving up to three gravitons and up to two color traces are reduced to partial amplitudes of pure Yang-Mills theory. In fact, the double-trace identities apply to Einstein-Yang-Mills extended by a dilaton and a B-field. Our results generalize recent work of Stieberger and Taylor for the single graviton case with a single color trace. As the derivation is made in the dimension-agnostic Cachazo-He-Yuan formalism, our results are valid for external bosons in any number of spacetime dimensions. Moreover, they generalize to the superamplitudes in theories with 16 supercharges.

  16. The cerebral cortex of Albert Einstein: a description and preliminary analysis of unpublished photographs.

    Science.gov (United States)

    Falk, Dean; Lepore, Frederick E; Noe, Adrianne

    2013-04-01

    Upon his death in 1955, Albert Einstein's brain was removed, fixed and photographed from multiple angles. It was then sectioned into 240 blocks, and histological slides were prepared. At the time, a roadmap was drawn that illustrates the location within the brain of each block and its associated slides. Here we describe the external gross neuroanatomy of Einstein's entire cerebral cortex from 14 recently discovered photographs, most of which were taken from unconventional angles. Two of the photographs reveal sulcal patterns of the medial surfaces of the hemispheres, and another shows the neuroanatomy of the right (exposed) insula. Most of Einstein's sulci are identified, and sulcal patterns in various parts of the brain are compared with those of 85 human brains that have been described in the literature. To the extent currently possible, unusual features of Einstein's brain are tentatively interpreted in light of what is known about the evolution of higher cognitive processes in humans. As an aid to future investigators, these (and other) features are correlated with blocks on the roadmap (and therefore histological slides). Einstein's brain has an extraordinary prefrontal cortex, which may have contributed to the neurological substrates for some of his remarkable cognitive abilities. The primary somatosensory and motor cortices near the regions that typically represent face and tongue are greatly expanded in the left hemisphere. Einstein's parietal lobes are also unusual and may have provided some of the neurological underpinnings for his visuospatial and mathematical skills, as others have hypothesized. Einstein's brain has typical frontal and occipital shape asymmetries (petalias) and grossly asymmetrical inferior and superior parietal lobules. Contrary to the literature, Einstein's brain is not spherical, does not lack parietal opercula and has non-confluent Sylvian and inferior postcentral sulci.

  17. G. Einstein matrix and nano-biophotonic treatment

    Science.gov (United States)

    Przybyl-Einstein, George; Moratin, Holdy; Garcia, Eduardo

    2005-04-01

    The publication is presenting the Einstein Matrix Treatment Method and initial results for blood borne diseases on example of hepatitis, HIV and arthritis. The initial research was conducted at Einstein Clinical Laboratories S.A. on limited funds. The treatment and method is strongly recommended for specific viruses bacteria in blood borne diseases but also for treatment of none specific viruses and bacteria in emergency treatments as SARS or ANTHRAX to safe life of the human. In the past years the Individual's Safety is in jeopardy by natural viral infections as well as by engineering cultured viruses and bacteria. Viruses mutate and become more resistant to current known medical treatment, in many cases partially efficient. This event required new testing method to investigate the possibility of treatments and to create new vaccine for non-specific viral and bacteria or viruses infections that causes death to thousands adults and children. The authors present in this paper the possibility of treatment of the non-specific viral, bacterial infections of the blood in human body. This treatment has safe procedure and no known side effect up to this time for patients that were treated at Einstein Clinical Laboratories SA.

  18. Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer

    International Nuclear Information System (INIS)

    Lee, Kiwon; Liu, Yin; Mo, Jun Qin; Zhang, Jinsong; Dong, Zhongyun; Lu, Shan

    2008-01-01

    Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor, and stimulates growth in prostate cancer cells. The current study is to determine a potential role of Vav3 oncogene in human breast cancer and impact on estrogen receptor a (ERα)-mediated signaling axis. Immunohistochemistry analysis was performed in 43 breast cancer specimens and western blot analysis was used for human breast cancer cell lines to determine the expression level of Vav3 protein. The impact of Vav3 on breast cancer cell growth was determined by siRNA knockdown of Vav3 expression. The role of Vav3 in ERα activation was examined in luciferase reporter assays. Deletion mutation analysis of Vav3 protein was performed to localize the functional domain involved in ERα activation. Finally, the interaction of Vav3 and ERα was assessed by GST pull-down analysis. We found that Vav3 was overexpressed in 81% of human breast cancer specimens, particularly in poorly differentiated lesions. Vav3 activated ERα partially via PI3K-Akt signaling and stimulated growth of breast cancer cells. Vav3 also potentiated EGF activity for cell growth and ERα activation in breast cancer cells. More interestingly, we found that Vav3 complexed with ERα. Consistent with its function for AR, the DH domain of Vav3 was essential for ERα activation. Vav3 oncogene is overexpressed in human breast cancer. Vav3 complexes with ERα and enhances ERα activity. These findings suggest that Vav3 overexpression may aberrantly enhance ERα-mediated signaling axis and play a role in breast cancer development and/or progression

  19. Einstein's daughter the search for Lieserl

    CERN Document Server

    Zackheim, Michele

    1999-01-01

    A thoroughly gripping and groundbreaking investigation into the mysterious fate of Albert Einstein's illegitimate daughter. Albert Einstein fell in love with Mileva Maric, the woman who would become his first wife, when they were students at the Zurich Polytechnic Institute. When Maric conceived a child out of wedlock, she went home to her family in Serbia to have the child. Lieserl Maric Einstein was born in 1902. Though Einstein and Maric married the following year, Lieserl was left in the care of her grandparents and never became a part of the Einstein family. In fact, her very existence was unknown until the recent discovery of a cache of letters between Einstein and Maric. The final reference to Lieserl comes in a September 1903 letter, when, at the age of approximately eighteen months, she simply disappears. What happened to Einstein's daughter is the most potent mystery to emerge from the mythology that surrounds one of the century's legendary figures, owing in large part to the careful and apparent...

  20. Calretinin as a marker for premotor neurons involved in upgaze in human brainstem

    Directory of Open Access Journals (Sweden)

    Christopher eAdamczyk

    2015-12-01

    Full Text Available Eye movements are generated by different premotor pathways. Damage to them can cause specific deficits of eye movements, such as saccades. For correlative clinico-anatomical post-mortem studies of cases with eye movement disorders it is essential to identify the functional cell groups of the oculomotor system in the human brain by marker proteins. Based on monkey studies, the premotor neurons of the saccadic system can be identified by the histochemical markers parvalbumin and perineuronal nets in humans. These areas involve the interstitial nucleus of Cajal (INC and the rostral interstitial nucleus of the medial longitudinal fascicle (RIMLF, which both contain premotor neurons for upgaze and downgaze. Recent monkey and human studies revealed a selective excitatory calretinin-positive input to the motoneurons mediating upgaze, but not to those for downgaze. Three premotor regions were identified as sources of calretinin input in monkey: y-group, INC and RIMLF. These findings suggest that the expression pattern of parvalbumin and calretinin may help to identify premotor neurons involved in up- or downgaze. In a post-mortem study of five human cases without neurological diseases we investigated the y-group, INC and RIMLF for the presence of parvalbumin and calretinin positive neurons including their co-expression. Adjacent thin paraffin sections were stained for the aggrecan component of perineuronal nets, parvalbumin or calretinin and glutamate decarboxylase. The comparative analysis of scanned thin sections of INC and RIMLF revealed medium-sized parvalbumin positive neurons with and without calretinin coexpression, which were intermingled. The parvalbumin/calretinin positive neurons in both nuclei are considered as excitatory premotor upgaze neurons. Accordingly, the parvalbumin-positive neurons lacking calretinin are considered as premotor downgaze neurons in RIMLF, but may in addition include inhibitory premotor upgaze neurons in the INC as

  1. The RNA helicase DDX1 is involved in restricted HIV-1 Rev function in human astrocytes

    International Nuclear Information System (INIS)

    Fang Jianhua; Acheampong, Edward; Dave, Rajnish; Wang Fengxiang; Mukhtar, Muhammad; Pomerantz, Roger J.

    2005-01-01

    Productive infection by human immunodeficiency virus type I (HIV-1) in the central nervous system (CNS) involves mainly macrophages and microglial cells. A frequency of less than 10% of human astrocytes is estimated to be infectable with HIV-1. Nonetheless, this relatively low percentage of infected astrocytes, but associated with a large total number of astrocytic cells in the CNS, makes human astrocytes a critical part in the analyses of potential HIV-1 reservoirs in vivo. Investigations in astrocytic cell lines and primary human fetal astrocytes revealed that limited HIV-1 replication in these cells resulted from low-level viral entry, transcription, viral protein processing, and virion maturation. Of note, a low ratio of unspliced versus spliced HIV-1-specific RNA was also investigated, as Rev appeared to act aberrantly in astrocytes, via loss of nuclear and/or nucleolar localization and diminished Rev-mediated function. Host cellular machinery enabling Rev function has become critical for elucidation of diminished Rev activity, especially for those factors leading to RNA metabolism. We have recently identified a DEAD-box protein, DDX1, as a Rev cellular co-factor and now have explored its potential importance in astrocytes. Cells were infected with HIV-1 pseudotyped with envelope glycoproteins of amphotropic murine leukemia viruses (MLV). Semi-quantitative reverse transcriptase-polymerase chain reactions (RT-PCR) for unspliced, singly-spliced, and multiply-spliced RNA clearly showed a lower ratio of unspliced/singly-spliced over multiply-spliced HIV-1-specific RNA in human astrocytes as compared to Rev-permissive, non-glial control cells. As well, the cellular localization of Rev in astrocytes was cytoplasmically dominant as compared to that of Rev-permissive, non-glial controls. This endogenous level of DDX1 expression in astrocytes was demonstrated directly to lead to a shift of Rev sub-cellular distribution dominance from nuclear and/or nucleolar to

  2. Human umbilical vein: involvement of cyclooxygenase-2 pathway in bradykinin B1 receptor-sensitized responses.

    Science.gov (United States)

    Errasti, A E; Rey-Ares, V; Daray, F M; Rogines-Velo, M P; Sardi, S P; Paz, C; Podestá, E J; Rothlin, R P

    2001-08-01

    In isolated human umbilical vein (HUV), the contractile response to des-Arg9-bradykinin (des-Arg9-BK), selective BK B1 receptor agonist, increases as a function of the incubation time. Here, we evaluated whether cyclooxygenase (COX) pathway is involved in BK B1-sensitized response obtained in 5-h incubated HUV rings. The effect of different concentrations of indomethacin, sodium salicylate, ibuprofen, meloxicam, lysine clonixinate or NS-398 administrated 30 min before concentration-response curves (CRC) was studied. All treatments produced a significant rightward shift of the CRC to des-Arg9-BK in a concentration-dependent manner, which provides pharmacological evidence that COX pathway is involved in the BK B1 responses. Moreover, in this tissue, the NS-398 pKb (5.2) observed suggests that COX-2 pathway is the most relevant. The strong correlation between published pIC50 for COX-2 and the NSAIDs' pKbs estimated further supports the hypothesis that COX-2 metabolites are involved in BK B1 receptor-mediated responses. In other rings, indomethacin (30, 100 micromol/l) or NS-398 (10, 30 micromol/l) produced a significant rightward shift of the CRC to BK, selective BK B2 agonist, and its pKbs were similar to the values to inhibit BK B1 receptor responses, suggesting that COX-2 pathway also is involved in BK B2 receptor responses. Western blot analysis shows that COX-1 and COX-2 isoenzymes are present before and after 5-h in vitro incubation and apparently COX-2 does not suffer additional induction.

  3. Einstein wrote back my life in physics

    CERN Document Server

    Moffat, John W

    2012-01-01

    John W. Moffat was a poor student of math and science. That is, until he read Einstein's famous paper on general relativity. Realizing instantly that he had an unusual and unexplained aptitude for understanding the complex physics described in the paper, Moffat wrote a letter to Einstein that would change the course of his life. Einstein Wrote Back tells the story of Moffat's unusual entry into the world of academia and documents his career at the frontlines of twentieth-century physics as he worked and associated with some of the greatest minds in scientific history, including Niels Bohr,

  4. Quantum theory and Einstein's general relativity

    International Nuclear Information System (INIS)

    Borzeszkowski, H. von; Treder, H.

    1982-01-01

    We dicusss the meaning and prove the accordance of general relativity, wave mechanics, and the quantization of Einstein's gravitation equations themselves. Firstly, we have the problem of the influence of gravitational fields on the de Broglie waves, which influence is in accordance with Einstein's weak principle of equivalence and the limitation of measurements given by Heisenberg's uncertainty relations. Secondly, the quantization of the gravitational fields is a ''quantization of geometry.'' However, classical and quantum gravitation have the same physical meaning according to limitations of measurements given by Einstein's strong principle of equivalence and the Heisenberg uncertainties for the mechanics of test bodies

  5. Einstein pictures the x-ray sky

    International Nuclear Information System (INIS)

    Hartline, B.K.

    1979-01-01

    The second High Energy Astronomy Observatory (HEAO-2, Einstein) is revolutionizing x-ray astronomy just as its namesake revolutionized physics. Earlier x-ray observatories, including HEAO-1, were designed to scan the sky for x-ray emitters. With Einstein, the challenge has shifted from discovering x-ray sources to understanding the processes producing the x-rays. But having 500 times the sensitivity of previous detectors, Einstein makes more than its share of discoveries, too. For example, it sees distant quasars and clusters of galaxies that can barely be detected by the largest optical telescopes

  6. Entanglement Equilibrium and the Einstein Equation.

    Science.gov (United States)

    Jacobson, Ted

    2016-05-20

    A link between the semiclassical Einstein equation and a maximal vacuum entanglement hypothesis is established. The hypothesis asserts that entanglement entropy in small geodesic balls is maximized at fixed volume in a locally maximally symmetric vacuum state of geometry and quantum fields. A qualitative argument suggests that the Einstein equation implies the validity of the hypothesis. A more precise argument shows that, for first-order variations of the local vacuum state of conformal quantum fields, the vacuum entanglement is stationary if and only if the Einstein equation holds. For nonconformal fields, the same conclusion follows modulo a conjecture about the variation of entanglement entropy.

  7. Rediscovering Einstein's legacy: How Einstein anticipates Kuhn and Feyerabend on the nature of science.

    Science.gov (United States)

    Oberheim, Eric

    2016-06-01

    Thomas Kuhn and Paul Feyerabend promote incommensurability as a central component of their conflicting accounts of the nature of science. This paper argues that in so doing, they both develop Albert Einstein's views, albeit in different directions. Einstein describes scientific revolutions as conceptual replacements, not mere revisions, endorsing 'Kant-on-wheels' metaphysics in light of 'world change'. Einstein emphasizes underdetermination of theory by evidence, rational disagreement in theory choice, and the non-neutrality of empirical evidence. Einstein even uses the term 'incommensurable' specifically to apply to challenges posed to comparatively evaluating scientific theories in 1949, more than a decade before Kuhn and Feyerabend. This analysis shows how Einstein anticipates substantial components of Kuhn and Feyerabend's views, and suggests that there are strong reasons to suspect that Kuhn and Feyerabend were directly inspired by Einstein's use of the term 'incommensurable', as well as his more general methodological and philosophical reflections. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. On some classes of super quasi-Einstein manifolds

    International Nuclear Information System (INIS)

    Ozguer, Cihan

    2009-01-01

    Quasi-Einstein and generalized quasi-Einstein manifolds are the generalizations of Einstein manifolds. In this study, we consider a super quasi-Einstein manifold, which is another generalization of an Einstein manifold. We find the curvature characterizations of a Ricci-pseudosymmetric and a quasi-conformally flat super quasi-Einstein manifolds. We also consider the condition C ∼ .S=0 on a super quasi-Einstein manifold, where C ∼ and S denote the quasi-conformal curvature tensor and Ricci tensor of the manifold, respectively.

  9. A human repair gene ERCC5 is involved in group G xeroderma pigmentosum

    International Nuclear Information System (INIS)

    Shiomi, Tadahiro

    1994-01-01

    In E. coli, ultraviolet-induced DNA damage is removed by the coordinated action of UVR A, B, C, and D proteins (1). In Saccharomyces cerevisiae, more than ten genes have been reported to be involved in excision repair (2). The nucleotide excision repair pathway has been extensively studied in these organisms. To facilitate studying nucleotide excision repair in mammalian cells. Ultraviolet-sensitive rodent cell mutants have been isolated and classified into 11 complementation groups (9,10). The human nucleotide excision repair genes which complement the defects of the mutants have been designated as the ERCC (excision repair cross-complementing) genes; a number is added to refer to the particular rodent complementation group that is corrected by the gene. Recently, several human DNA repair genes have been cloned using rodent cell lines sensitive to ultraviolet. These include ERCC2 (3), ERCC3 (4), and ERCC6 (5), which correspond to the defective genes in the ultraviolet-sensitive human disorders xeroderma pigmentosum (XP) group D (6) and group B (4), and Cockayne's syndrome (CS) group B (7), respectively. The human excision repair gene ERCC5 was cloned after DNA-mediated gene transfer of human HeLa cell genomic DNA into the ultraviolet-sensitive mouse mutant XL216, a member of rodent complementation group 5 (11,12) and the gene was mapped on human chromosome 13q32.3-q33.1 by the replication R-banding fluorescence in situ hybridization method (13). The ERCC5 cDNA encodes a predicted 133 kDa nuclear protein that shares some homology with product of the yeast DNA repair gene RAD 2. Transfection with mouse ERCC5 cDNA restored normal levels of ultraviolet-resistance to XL216 cells. Microinjection of ERCC5 cDNA specifically restored the defect of XP group G cells (XP-G) as measured by unscheduled DNA synthesis (UDS), and XP-G cells stably transformed with ERCC5 cDNA showed nearly normal ultraviolet resistance. (J.P.N.)

  10. Canadian governance of health research involving human subjects: is anybody minding the store?

    Science.gov (United States)

    McDonald, M

    2001-01-01

    From an ethical perspective, good governance involves the translation of collective moral intentions into effective and accountable institutional actions. With respect to the use of human subjects in Canadian health research, I contend that there have been many good intentions but very little in the way of appropriate governance arrangements. Hence, the question, "who minds the store?" is especially acute with respect to the protection of vulnerable individuals and groups that are typically recruited as subjects for health research in Canada. Beyond diagnosing failures in governance and their causes, I offer suggestions for significant reforms, including evidence-based ethics assessment, independent oversight, and greater participation of research subjects in governance. I will close with some more general reflections on ethics, law, and governance.

  11. Envolvimento nos direitos humanos e sistemas de valores Involvement in human rights and value systems

    Directory of Open Access Journals (Sweden)

    Cícero Pereira

    2004-04-01

    Full Text Available Com base no modelo da análise quantitativa das representações sociais, o estudo (N = 300 tratou do posicionamento de estudantes universitários em relação aos Direitos Humanos (DHs e à ancoragem social desse posicionamento nos sistemas de valores dos estudantes. Os resultados mostram que as representações dos estudantes sobre o envolvimento nos DHs envolvem quatro princípios organizadores: pessoal-abstrato; pessoal-concreto; governamental-abstrato; governamental-concreto. Em relação à ancoragem social dos princípios organizadores do envolvimento nos DHs, observou-se que os valores pós-materialistas se relacionaram positivamente com o envolvimento pessoal-abstrato, enquanto a adesão aos valores religiosos implicou maior envolvimento no princípio pessoal-concreto. Além disso, a adesão aos valores materialistas levou a uma avaliação mais positiva do envolvimento do Governo Brasileiro nos DHs, ao passo que os valores pós-materialistas contribuíram com uma avaliação mais crítica desse governo. As discussões abordam a centralidade dos valores na formação das representações sociais dos DHs.Based on the quantitative analysis model of social representations, a study (N=300 was carried out concerning the opinion of university students on Human Rights (HR, and the social link of this positioning in the students system of values. The results show that the students representations of the involvement in HR comprise four organizing principles: personal-abstract; personal-concrete; governmental-abstract; governmental-concrete. With regard to the social anchorage of the organizing principles of involvement in HR, it has been observed that post-materialist values were positively related to the involvement personal-abstract, whereas adherence to religious values implied a greater involvement in the personal-concrete principle. In addition, adherence to materialist values led to a more positive appraisal of the Brazilian Government

  12. Einstein and General Relativity: Historical Perspectives.

    Science.gov (United States)

    Chandrasekhar, S.

    1979-01-01

    This paper presented in the 1978 Oppenheimer Memorial Lecture at Los Alamos Scientific Laboratories on August 17, 1978, discusses Einstein's contributions to physics, in particular, his discovery of the general theory of relativity. (HM)

  13. Covariant Conformal Decomposition of Einstein Equations

    Science.gov (United States)

    Gourgoulhon, E.; Novak, J.

    It has been shown1,2 that the usual 3+1 form of Einstein's equations may be ill-posed. This result has been previously observed in numerical simulations3,4. We present a 3+1 type formalism inspired by these works to decompose Einstein's equations. This decomposition is motivated by the aim of stable numerical implementation and resolution of the equations. We introduce the conformal 3-``metric'' (scaled by the determinant of the usual 3-metric) which is a tensor density of weight -2/3. The Einstein equations are then derived in terms of this ``metric'', of the conformal extrinsic curvature and in terms of the associated derivative. We also introduce a flat 3-metric (the asymptotic metric for isolated systems) and the associated derivative. Finally, the generalized Dirac gauge (introduced by Smarr and York5) is used in this formalism and some examples of formulation of Einstein's equations are shown.

  14. How History Helped Einstein in Special Relativity

    Science.gov (United States)

    Martinez, Alberto

    2013-04-01

    I will discuss how the German intellectual movement known as ``critical history'' motivated several physicists in the late 1900s to radically analyze the fundamental principles of mechanics, leading eventually to Einstein's special theory of relativity. Eugen Karl Dühring, Johann Bernhard Stallo, Ludwig Lange, and Ernst Mach wrote critical histories of mechanics, some of which emphasized notions of relativity and observation, in opposition to old metaphysical concepts that seemed to infect the foundations of physics. This strand of critical history included the ``genetic method'' of analyzing how concepts develop over time, in our minds, by way of ordinary experiences, which by 1904 was young Albert Einstein's favorite approach for examining fundamental notions. Thus I will discuss how history contributed in Einstein's path to relativity, as well as comment more generally on Einstein's views on history.

  15. Bose-Einstein condensation and crystallization

    International Nuclear Information System (INIS)

    Suetoe, A.

    2008-01-01

    The paper describes history and state of art theory of Bose-Einstein condensation and crystallization as cases of breaking continuous symmetries. Emphasizes that these problems have not been solved exactly. (TRA)

  16. Universal Themes of Bose-Einstein Condensation

    Science.gov (United States)

    Proukakis, Nick P.; Snoke, David W.; Littlewood, Peter B.

    2017-04-01

    Foreword; List of contributors; Preface; Part I. Introduction: 1. Universality and Bose-Einstein condensation: perspectives on recent work D. W. Snoke, N. P. Proukakis, T. Giamarchi and P. B. Littlewood; 2. A history of Bose-Einstein condensation of atomic hydrogen T. Greytak and D. Kleppner; 3. Twenty years of atomic quantum gases: 1995-2015 W. Ketterle; 4. Introduction to polariton condensation P. B. Littlewood and A. Edelman; Part II. General Topics: Editorial notes; 5. The question of spontaneous symmetry breaking in condensates D. W. Snoke and A. J. Daley; 6. Effects of interactions on Bose-Einstein condensation R. P. Smith; 7. Formation of Bose-Einstein condensates M. J. Davis, T. M. Wright, T. Gasenzer, S. A. Gardiner and N. P. Proukakis; 8. Quenches, relaxation and pre-thermalization in an isolated quantum system T. Langen and J. Schmiedmayer; 9. Ultracold gases with intrinsic scale invariance C. Chin; 10. Berezinskii-Kosterlitz-Thouless phase of a driven-dissipative condensate N. Y. Kim, W. H. Nitsche and Y. Yamamoto; 11. Superfluidity and phase correlations of driven dissipative condensates J. Keeling, L. M. Sieberer, E. Altman, L. Chen, S. Diehl and J. Toner; 12. BEC to BCS crossover from superconductors to polaritons A. Edelman and P. B. Littlewood; Part III. Condensates in Atomic Physics: Editorial notes; 13. Probing and controlling strongly correlated quantum many-body systems using ultracold quantum gases I. Bloch; 14. Preparing and probing chern bands with cold atoms N. Goldman, N. R. Cooper and J. Dalibard; 15. Bose-Einstein condensates in artificial gauge fields L. J. LeBlanc and I. B. Spielman; 16. Second sound in ultracold atomic gases L. Pitaevskii and S. Stringari; 17. Quantum turbulence in atomic Bose-Einstein condensates N. G. Parker, A. J. Allen, C. F. Barenghi and N. P. Proukakis; 18. Spinor-dipolar aspects of Bose-Einstein condensation M. Ueda; Part IV. Condensates in Condensed Matter Physics: Editorial notes; 19. Bose-Einstein

  17. Recent developments in Bose-Einstein condensation

    International Nuclear Information System (INIS)

    Kalman, G.

    1997-01-01

    This paper contains viewgraphs on developments on Bose-Einstein condensation. Some topics covered are: strongly coupled coulomb systems; standard response functions of the first and second kind; dynamical mean field theory; quasi localized charge approximation; and the main equations

  18. Development of Einstein's general theory of relativity

    International Nuclear Information System (INIS)

    Datta, B.K.

    1980-01-01

    Starting from Poincare's Lorentz-invariant theory of gravity formulated in 1906, development of Einstein's general theory of relativity during 1906-1916 is discussed. Three stages in this development are recognised. In the first stage during 1907-1914, Einstein tried to extend the relativity principle of uniform motion to the frames in non-uniform motion. For this purpose, he introduced the principle of equivalence which made it possible to calculate the effect of homogeneous gravitational field on arbitrary physical processes. During the second stage comprising years 1912-1914 overlapping the first stage, Einstein and Grossmann were struggling to translate physical postulates into the language of the absolute differential calculus. In the period 1915-1916, Einstein formulated the field equations of general relativity. While discussing these developmental stages, theories of gravitation formulated by Abraham, Nordstroem and Mie are also discussed. (M.G.B.)

  19. Recent developments in Bose-Einstein condensation

    Energy Technology Data Exchange (ETDEWEB)

    Kalman, G.

    1997-09-22

    This paper contains viewgraphs on developments on Bose-Einstein condensation. Some topics covered are: strongly coupled coulomb systems; standard response functions of the first and second kind; dynamical mean field theory; quasi localized charge approximation; and the main equations.

  20. Involvement of Endoplasmic Reticulum Stress in Capsaicin-Induced Apoptosis of Human Pancreatic Cancer Cells

    Directory of Open Access Journals (Sweden)

    Shengzhang Lin

    2013-01-01

    Full Text Available Capsaicin, main pungent ingredient of hot chilli peppers, has been shown to have anticarcinogenic effect on various cancer cells through multiple mechanisms. In this study, we investigated the apoptotic effect of capsaicin on human pancreatic cancer cells in both in vitro and in vivo systems, as well as the possible mechanisms involved. In vitro, treatment of both the pancreatic cancer cells (PANC-1 and SW1990 with capsaicin resulted in cells growth inhibition, G0/G1 phase arrest, and apoptosis in a dose-dependent manner. Knockdown of growth arrest- and DNA damage-inducible gene 153 (GADD153, a marker of the endoplasmic-reticulum-stress- (ERS- mediated apoptosis pathway, by specific siRNA attenuated capsaicin-induced apoptosis both in PANC-1 and SW1990 cells. Moreover, in vivo studies capsaicin effectively inhibited the growth and metabolism of pancreatic cancer and prolonged the survival time of pancreatic cancer xenograft tumor-induced mice. Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78, phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK, and phosphoeukaryotic initiation factor-2α (phospho-eIF2α, activating transcription factor 4 (ATF4 and GADD153 in tumor tissues. In conclusion, we for the first time provide important evidence to support the involvement of ERS in the induction of apoptosis in pancreatic cancer cells by capsaicin.

  1. Structural insights into human Kif7, a kinesin involved in Hedgehog signalling

    Energy Technology Data Exchange (ETDEWEB)

    Klejnot, Marta, E-mail: m.klejnot@beatson.gla.ac.uk; Kozielski, Frank, E-mail: m.klejnot@beatson.gla.ac.uk [The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland (United Kingdom)

    2012-02-01

    The human Kif7 motor domain structure provides insights into a kinesin of medical significance. Kif7, a member of the kinesin 4 superfamily, is implicated in a variety of diseases including Joubert, hydrolethalus and acrocallosal syndromes. It is also involved in primary cilium formation and the Hedgehog signalling pathway and may play a role in cancer. Its activity is crucial for embryonic development. Kif7 and Kif27, a closely related kinesin in the same subfamily, are orthologues of the Drosophila melano@@gaster kinesin-like protein Costal-2 (Cos2). In vertebrates, they work together to fulfil the role of the single Cos2 gene in Drosophila. Here, the high-resolution structure of the human Kif7 motor domain is reported and is compared with that of conventional kinesin, the founding member of the kinesin superfamily. These data are a first step towards structural characterization of a kinesin-4 family member and of this interesting molecular motor of medical significance.

  2. Persistent Amplification of DNA Damage Signal Involved in Replicative Senescence of Normal Human Diploid Fibroblasts

    Directory of Open Access Journals (Sweden)

    Masatoshi Suzuki

    2012-01-01

    Full Text Available Foci of phosphorylated histone H2AX and ATM are the surrogate markers of DNA double strand breaks. We previously reported that the residual foci increased their size after irradiation, which amplifies DNA damage signals. Here, we addressed whether amplification of DNA damage signal is involved in replicative senescence of normal human diploid fibroblasts. Large phosphorylated H2AX foci (>1.5 μm diameter were specifically detected in presenescent cells. The frequency of cells with large foci was well correlated with that of cells positive for senescence-associated β-galactosidase staining. Hypoxic cell culture condition extended replicative life span of normal human fibroblast, and we found that the formation of large foci delayed in those cells. Our immuno-FISH analysis revealed that large foci partially localized at telomeres in senescent cells. Importantly, large foci of phosphorylated H2AX were always colocalized with phosphorylated ATM foci. Furthermore, Ser15-phosphorylated p53 showed colocalization with the large foci. Since the treatment of senescent cells with phosphoinositide 3-kinase inhibitor, wortmannin, suppressed p53 phosphorylation, it is suggested that amplification of DNA damage signaling sustains persistent activation of ATM-p53 pathway, which is essential for replicative senescence.

  3. Human factors involvement in bringing the power of AI to a heterogeneous user population

    Science.gov (United States)

    Czerwinski, Mary; Nguyen, Trung

    1994-01-01

    The Human Factors involvement in developing COMPAQ QuickSolve, an electronic problem-solving and information system for Compaq's line of networked printers, is described. Empowering customers with expert system technology so they could solve advanced networked printer problems on their own was a major goal in designing this system. This process would minimize customer down-time, reduce the number of phone calls to the Compaq Customer Support Center, improve customer satisfaction, and, most importantly, differentiate Compaq printers in the marketplace by providing the best, and most technologically advanced, customer support. This represents a re-engineering of Compaq's customer support strategy and implementation. In its first generation system, SMART, the objective was to provide expert knowledge to Compaq's help desk operation to more quickly and correctly answer customer questions and problems. QuickSolve is a second generation system in that customer support is put directly in the hands of the consumers. As a result, the design of QuickSolve presented a number of challenging issues. Because the produce would be used by a diverse and heterogeneous set of users, a significant amount of human factors research and analysis was required while designing and implementing the system. Research that shaped the organization and design of the expert system component as well.

  4. Protease activation involved in resistance of human cells to x-ray cell killing

    International Nuclear Information System (INIS)

    Zhang, Hong-Chang; Takahashi, Shuji; Karata, Kiyonobu; Kita, Kazuko; Suzuki, Nobuo

    2003-01-01

    Little is known of proteases that play roles in the early steps of X-ray irradiation response. In the present study, we first searched for proteases whose activity is induced in human RSa-R cells after X-ray irradiation. The activity was identified as fibrinolytic, using 125 I-labeled fibrin as a substrate. Protease samples were prepared by lysation of cells with a buffer containing MEGA-8. RSa-R cells showed an increased level of protease activity 10 min after X-ray (up to 3 Gy) irradiation. We next examined whether this protease inducibility is causally related with the X-ray susceptibility of cells. Leupeptin, a serine-cysteine protease inhibitor, inhibited the protease activity in samples obtained from X-ray-irradiated RSa-R cells. Treatment of RSa-R cells with the inhibitor before and after X-ray irradiation resulted in an increased susceptibility of the cells to X-ray cell killing. However, the treatment of cells with other inhibitors tested did not modulate the X-ray susceptibility. These results suggest that leupeptin-sensitive proteases are involved in the resistance of human cells to X-ray cell killing. (author)

  5. Mycobacterium leprae antigens involved in human immune responses. I. Identification of four antigens by monoclonal antibodies

    Energy Technology Data Exchange (ETDEWEB)

    Britton, W.J.; Hellqvist, L.; Basten, A.; Raison, R.L.

    1985-12-01

    Four distinct antigens were identified in soluble sonicates of Mycobacterium leprae by using a panel of 11 monoclonal antibodies. Cross-reactivity studies with other mycobacterial species were conducted by using ELISA and immunoblot assays, and demonstrated that determinants on two of the antigens were present in many mycobacteria, whereas the other two were limited in distribution. Competitive inhibition experiments with radiolabeled monoclonal antibodies showed cross-inhibition between antibodies identifying two of the four antigenicbands. These two bands, of M/sub tau/ 4.5 to 6 KD and 30 to 40 KD, were resistant to protease treatment after immunoblotting. In contrast the two other bands of 16 and 70 KD were protease-sensitive. Although all four bands reacted with some human lepromatous leprosy sera in immunoblots, the 4.5 to 6 KD and 30 to 40 KD bands were most prominent. Lepromatous leprosy sera also inhibited the binding of radiolabeled monoclonal antibodies to each of the four antigens, with the mean titer causing 50% inhibition being higher for antibodies reacting with the 4.5 to 6 KD and 30 to 40 KD bands. These findings indicated that all four antigens were involved in the human B cell response to M. leprae.

  6. The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis.

    Science.gov (United States)

    Dijkman, Henry; Smeets, Bart; van der Laak, Jeroen; Steenbergen, Eric; Wetzels, Jack

    2005-10-01

    Focal segmental glomerulosclerosis (FSGS) is one of the most common patterns of glomerular injury encountered in human renal biopsies. Epithelial hyperplasia, which can be prominent in FSGS, has been attributed to dedifferentiation and proliferation of podocytes. Based on observations in a mouse model of FSGS, we pointed to the role of parietal epithelial cells (PECs). In the present study we investigated the relative role of PECs and podocytes in human idiopathic FSGS. We performed a detailed study of lesions from a patient with recurrent idiopathic FSGS by serial sectioning, marker analysis and three-dimensional reconstruction of glomeruli. We have studied the expression of markers for podocytes, PECs, mesangial cells, endothelium, and myofibroblasts. We also looked at proliferation and composition of the deposited extracellular matrix (ECM). We found that proliferating epithelial cells in FSGS lesions are negative for podocyte and macrophage markers, but stain for PEC markers. The composition of the matrix deposited by these cells is identical to Bowman's capsule. Our study demonstrates that PECs are crucially involved in the pathogenesis of FSGS lesions.

  7. DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients

    Directory of Open Access Journals (Sweden)

    Ludovica Segat

    2014-11-01

    Full Text Available The human beta defensin 1 (hBD-1 antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV. In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.

  8. Effect of platelet lysate on human cells involved in different phases of wound healing.

    Science.gov (United States)

    Barsotti, Maria Chiara; Chiara Barsotti, Maria; Losi, Paola; Briganti, Enrica; Sanguinetti, Elena; Magera, Angela; Al Kayal, Tamer; Feriani, Roberto; Di Stefano, Rossella; Soldani, Giorgio

    2013-01-01

    Platelets are rich in mediators able to positively affect cell activity in wound healing. Aim of this study was to characterize the effect of different concentrations of human pooled allogeneic platelet lysate on human cells involved in the different phases of wound healing (inflammatory phase, angiogenesis, extracellular matrix secretion and epithelialization). Platelet lysate effect was studied on endothelial cells, monocytes, fibroblasts and keratinocytes, in terms of viability and proliferation, migration, angiogenesis, tissue repair pathway activation (ERK1/2) and inflammatory response evaluation (NFκB). Results were compared both with basal medium and with a positive control containing serum and growth factors. Platelet lysate induced viability and proliferation at the highest concentrations tested (10% and 20% v/v). Whereas both platelet lysate concentrations increased cell migration, only 20% platelet lysate was able to significantly promote angiogenic activity (pplatelet lysate concentrations activated important inflammatory pathways such as ERK1/2 and NFκB with the same early kinetics, whereas the effect was different for later time-points. These data suggest the possibility of using allogeneic platelet lysate as both an alternative to growth factors commonly used for cell culture and as a tool for clinical regenerative application for wound healing.

  9. Effect of platelet lysate on human cells involved in different phases of wound healing.

    Directory of Open Access Journals (Sweden)

    Maria Chiara Barsotti

    Full Text Available BACKGROUND: Platelets are rich in mediators able to positively affect cell activity in wound healing. Aim of this study was to characterize the effect of different concentrations of human pooled allogeneic platelet lysate on human cells involved in the different phases of wound healing (inflammatory phase, angiogenesis, extracellular matrix secretion and epithelialization. METHODOLOGY/PRINCIPAL FINDINGS: Platelet lysate effect was studied on endothelial cells, monocytes, fibroblasts and keratinocytes, in terms of viability and proliferation, migration, angiogenesis, tissue repair pathway activation (ERK1/2 and inflammatory response evaluation (NFκB. Results were compared both with basal medium and with a positive control containing serum and growth factors. Platelet lysate induced viability and proliferation at the highest concentrations tested (10% and 20% v/v. Whereas both platelet lysate concentrations increased cell migration, only 20% platelet lysate was able to significantly promote angiogenic activity (p<0.05 vs. control, comparably to the positive control. Both platelet lysate concentrations activated important inflammatory pathways such as ERK1/2 and NFκB with the same early kinetics, whereas the effect was different for later time-points. CONCLUSION/SIGNIFICANCE: These data suggest the possibility of using allogeneic platelet lysate as both an alternative to growth factors commonly used for cell culture and as a tool for clinical regenerative application for wound healing.

  10. Mycobacterium leprae antigens involved in human immune responses. I. Identification of four antigens by monoclonal antibodies

    International Nuclear Information System (INIS)

    Britton, W.J.; Hellqvist, L.; Basten, A.; Raison, R.L.

    1985-01-01

    Four distinct antigens were identified in soluble sonicates of Mycobacterium leprae by using a panel of 11 monoclonal antibodies. Cross-reactivity studies with other mycobacterial species were conducted by using ELISA and immunoblot assays, and demonstrated that determinants on two of the antigens were present in many mycobacteria, whereas the other two were limited in distribution. Competitive inhibition experiments with radiolabeled monoclonal antibodies showed cross-inhibition between antibodies identifying two of the four antigenicbands. These two bands, of M/sub tau/ 4.5 to 6 KD and 30 to 40 KD, were resistant to protease treatment after immunoblotting. In contrast the two other bands of 16 and 70 KD were protease-sensitive. Although all four bands reacted with some human lepromatous leprosy sera in immunoblots, the 4.5 to 6 KD and 30 to 40 KD bands were most prominent. Lepromatous leprosy sera also inhibited the binding of radiolabeled monoclonal antibodies to each of the four antigens, with the mean titer causing 50% inhibition being higher for antibodies reacting with the 4.5 to 6 KD and 30 to 40 KD bands. These findings indicated that all four antigens were involved in the human B cell response to M. leprae

  11. Sociotechnical Human Factors Involved in Remote Online Usability Testing of Two eHealth Interventions.

    Science.gov (United States)

    Wozney, Lori M; Baxter, Pamela; Fast, Hilary; Cleghorn, Laura; Hundert, Amos S; Newton, Amanda S

    2016-02-03

    Research in the fields of human performance technology and human computer interaction are challenging the traditional macro focus of usability testing arguing for methods that help test moderators assess "use in context" (ie, cognitive skills, usability understood over time) and in authentic "real world" settings. Human factors in these complex test scenarios may impact on the quality of usability results being derived yet there is a lack of research detailing moderator experiences in these test environments. Most comparative research has focused on the impact of the physical environment on results, and rarely on how the sociotechnical elements of the test environment affect moderator and test user performance. Improving our understanding of moderator roles and experiences with conducting "real world" usability testing can lead to improved techniques and strategies To understand moderator experiences of using Web-conferencing software to conduct remote usability testing of 2 eHealth interventions. An exploratory case study approach was used to study 4 moderators' experiences using Blackboard Collaborate for remote testing sessions of 2 different eHealth interventions. Data collection involved audio-recording iterative cycles of test sessions, collecting summary notes taken by moderators, and conducting 2 90-minute focus groups via teleconference. A direct content analysis with an inductive coding approach was used to explore personal accounts, assess the credibility of data interpretation, and generate consensus on the thematic structure of the results. Following the convergence of data from the various sources, 3 major themes were identified: (1) moderators experienced and adapted to unpredictable changes in cognitive load during testing; (2) moderators experienced challenges in creating and sustaining social presence and untangling dialogue; and (3) moderators experienced diverse technical demands, but were able to collaboratively troubleshoot with test users

  12. On the stability of the Einstein universe

    International Nuclear Information System (INIS)

    Soares, I.D.

    1983-01-01

    It is shown sthat the Einstein Universe is stable by a large class of exact perturbations, which are made starting from a detailed exam of the topology of the model, and which include perturbations of the type considered by Lemaitre. The problem is reduced to the one-dimensional motion of a particle, in a potential well whose minimum corresponds to the configuration of the Einstein Universe. (Author) [pt

  13. Stationary axisymmetric Einstein--Maxwell field equations

    International Nuclear Information System (INIS)

    Catenacci, R.; Diaz Alonso, J.

    1976-01-01

    We show the existence of a formal identity between Einstein's and Ernst's stationary axisymmetric gravitational field equations and the Einstein--Maxwell and the Ernst equations for the electrostatic and magnetostatic axisymmetric cases. Our equations are invariant under very simple internal symmetry groups, and one of them appears to be new. We also obtain a method for associating two stationary axisymmetric vacuum solutions with every electrostatic known

  14. Einstein and solid-state physics

    International Nuclear Information System (INIS)

    Aut, I.

    1982-01-01

    A connection between the development of solid-state physics and the works and activity of Albert Einstein is traced. A tremendous Einstein contribution to solid state physics is marked. A strict establishment of particle-wave dualism; a conclusion about the applicability of the Plank radiation law not only to black body radiation; finding out particles indistinguishability - all three discoveries have a principle significance for solid state physics too

  15. String Theory has Einstein's dream come true?

    CERN Multimedia

    CERN. Geneva

    2005-01-01

    After having outlined the difficulties that Einstein and others have encountered in trying to unify our understanding of macroscopic/classical and microscopic /quantum physics, I will explain in simple terms how the latest particle theory revolution, string theory, may finally offer a surprisingly simple realization of these long-standing dreams. Einstein thought that his difficulties stemmed from a clash between the classical and the quantum. Yet, paradoxically, superstrings appear to realize his dream thanks to -and not against- quantum mechanics.

  16. Radiating Kerr particle in Einstein universe

    International Nuclear Information System (INIS)

    Vaidya, P.C.; Patel, L.K.

    1989-01-01

    A generalized Kerr-NUT type metric is considered in connection with Einstein field equations corresponding to perfect fluid plus a pure radiation field. A general scheme for obtaining the exact solutions of these field equations is developed. Two physically meaningful particular cases are investigated in detail. One gives the field of a radiating Kerr particle embedded in the Einstein universe. The other solution may probably represent a deSitter-like universe pervaded by a pure radiation field. (author). 7 refs

  17. Gravitational curvature: an introduction to Einstein's theory

    International Nuclear Information System (INIS)

    Frankel, T.

    1979-01-01

    The basic aspects of general relativity are presented from a geometric point of view. The content of the book is well indicated by chapter headings: aspects of special relativity, clocks and gravitational potential, a heuristic derivation of Einstein's equations, the geometry of Einstein's equations, the Schwarzschild solution, the classical motion of a continuum, the relativistic equations of motion, light rays and Fermat's principle, electromagnetism in three-space and Minkowski space, electromagnetism in general relativity, the interior solution, and cosmology. 28 figures

  18. Oxidized low density lipoprotein increases RANKL level in human vascular cells. Involvement of oxidative stress

    Energy Technology Data Exchange (ETDEWEB)

    Mazière, Cécile, E-mail: maziere.cecile@chu-amiens.fr [Biochemistry Laboratory, South Hospital University, René Laennec Avenue, Amiens 80000 (France); Salle, Valéry [Internal Medicine, North Hospital University, Place Victor Pauchet, Amiens 80000 (France); INSERM U1088 (EA 4292), SFR CAP-Santé (FED 4231), University of Picardie – Jules Verne (France); Gomila, Cathy; Mazière, Jean-Claude [Biochemistry Laboratory, South Hospital University, René Laennec Avenue, Amiens 80000 (France)

    2013-10-18

    Highlights: •Oxidized LDL enhances RANKL level in human smooth muscle cells. •The effect of OxLDL is mediated by the transcription factor NFAT. •UVA, H{sub 2}O{sub 2} and buthionine sulfoximine also increase RANKL level. •All these effects are observed in human fibroblasts and endothelial cells. -- Abstract: Receptor Activator of NFκB Ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) have been shown to play a role not only in bone remodeling but also in inflammation, arterial calcification and atherosclerotic plaque rupture. In human smooth muscle cells, Cu{sup 2+}-oxidized LDL (CuLDL) 10–50 μg/ml increased reactive oxygen species (ROS) and RANKL level in a dose-dependent manner, whereas OPG level was not affected. The lipid extract of CuLDL reproduced the effects of the whole particle. Vivit, an inhibitor of the transcription factor NFAT, reduced the CuLDL-induced increase in RANKL, whereas PKA and NFκB inhibitors were ineffective. LDL oxidized by myeloperoxidase (MPO-LDL), or other pro-oxidant conditions such as ultraviolet A (UVA) irradiation, incubation with H{sub 2}O{sub 2} or with buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis{sub ,} also induced an oxidative stress and enhanced RANKL level. The increase in RANKL in pro-oxidant conditions was also observed in fibroblasts and endothelial cells. Since RANKL is involved in myocardial inflammation, vascular calcification and plaque rupture, this study highlights a new mechanism whereby OxLDL might, by generation of an oxidative stress, exert a deleterious effect on different cell types of the arterial wall.

  19. Cellular processes involved in human epidermal cells exposed to extremely low frequency electric fields.

    Science.gov (United States)

    Collard, J-F; Hinsenkamp, M

    2015-05-01

    We observed on different tissues and organisms a biological response after exposure to pulsed low frequency and low amplitude electric or electromagnetic fields but the precise mechanism of cell response remains unknown. The aim of this publication is to understand, using bioinformatics, the biological relevance of processes involved in the modification of gene expression. The list of genes analyzed was obtained after microarray protocol realized on cultures of human epidermal explants growing on deepidermized human skin exposed to a pulsed low frequency electric field. The directed acyclic graph on a WebGestalt Gene Ontology module shows six categories under the biological process root: "biological regulation", "cellular process", "cell proliferation", "death", "metabolic process" and "response to stimulus". Enriched derived categories are coherent with the type of in vitro culture, the stimulation protocol or with the previous results showing a decrease of cell proliferation and an increase of differentiation. The Kegg module on WebGestalt has highlighted "cell cycle" and "p53 signaling pathway" as significantly involved. The Kegg website brings out interactions between FoxO, MAPK, JNK, p53, p38, PI3K/Akt, Wnt, mTor or NF-KappaB. Some genes expressed by the stimulation are known to have an exclusive function on these pathways. Analyses performed with Pathway Studio linked cell proliferation, cell differentiation, apoptosis, cell cycle, mitosis, cell death etc. with our microarrays results. Medline citation generated by the software and the fold change variation confirms a diminution of the proliferation, activation of the differentiation and a less well-defined role of apoptosis or wound healing. Wnt and DKK functional classes, DKK1, MACF1, ATF3, MME, TXNRD1, and BMP-2 genes proposed in previous publications after a manual analysis are also highlighted with other genes after Pathway Studio automatic procedure. Finally, an analysis conducted on a list of genes

  20. Einstein model for elementary particles

    International Nuclear Information System (INIS)

    Sharma, N.K.

    1975-01-01

    A group theoretical model unifying a space-time group (E) and an internal symmetry group (I) for strongly interacting particles is worked out. The space-time group is the one that pertains to the group of motions of static Einstein cosmological model implying the symmetry of the group E = O 4 logical operation of multiplication R. With the use of Gueret and Vigier prescription, the left coset R logical operation of multiplication O 4 is identified with the internal symmetry group I = U 1 β logical operation of multiplication (SU(2) logical operation of multiplication SU(2)) contains SU(4). The complete dynamical group (D) is then found to be D = E logical operation of multiplication I = (O logical operation of multiplication R) logical operation of multiplication U 1 β logical operation of multiplication (SU(2) logical operation of multiplication SU(2) contains SO(4,2). Physically useful representations of the space-time group (E) are worked out by solving the eigenvalue problem of Laplace-Beltmi operator. The internal quantum numbers are prescribed in accordance with the SU(2) logical operation of multiplication SU(2) model of Nakamura and Sato. A general mass formula is derived and its use for known baryons and mesons is discussed. (author)

  1. Zeeman en Einstein. Meeslepende metingen

    Directory of Open Access Journals (Sweden)

    Ad Maas

    2016-10-01

    Full Text Available Zeeman and EinsteinThis article discusses an early example of interferometric, experimental research related to Einstein’s Special Theory of Relativity. This research concerned two series of experiments on the velocity of light in moving media, conducted between 1914 and 1921 by the Amsterdam physicist Pieter Zeeman. With the first of these series, on the velocity of light in moving water, Zeeman obtained an important result that validated the so called ‘dispersion term’ of the formula for the velocity of light in moving media. Less clear is the scientific objective of the second series, in which Zeeman measured the velocity of light in moving solid media. It seems that Zeeman’s interest in this second series was triggered mainly by the technical challenges posed by these experiments. In this way, they reveal the increasing tendency of Zeeman’s later research to be led by technical and experimental challenges, rather than by the actual scientific developments.

  2. Stochastic quantization of Einstein gravity

    International Nuclear Information System (INIS)

    Rumpf, H.

    1986-01-01

    We determine a one-parameter family of covariant Langevin equations for the metric tensor of general relativity corresponding to DeWitt's one-parameter family of supermetrics. The stochastic source term in these equations can be expressed in terms of a Gaussian white noise upon the introduction of a stochastic tetrad field. The only physically acceptable resolution of a mathematical ambiguity in the ansatz for the source term is the adoption of Ito's calculus. By taking the formal equilibrium limit of the stochastic metric a one-parameter family of covariant path-integral measures for general relativity is obtained. There is a unique parameter value, distinguished by any one of the following three properties: (i) the metric is harmonic with respect to the supermetric, (ii) the path-integral measure is that of DeWitt, (iii) the supermetric governs the linearized Einstein dynamics. Moreover the Feynman propagator corresponding to this parameter is causal. Finally we show that a consistent stochastic perturbation theory gives rise to a new type of diagram containing ''stochastic vertices.''

  3. Focus on quantum Einstein gravity Focus on quantum Einstein gravity

    Science.gov (United States)

    Ambjorn, Jan; Reuter, Martin; Saueressig, Frank

    2012-09-01

    The gravitational asymptotic safety program summarizes the attempts to construct a consistent and predictive quantum theory of gravity within Wilson's generalized framework of renormalization. Its key ingredient is a non-Gaussian fixed point of the renormalization group flow which controls the behavior of the theory at trans-Planckian energies and renders gravity safe from unphysical divergences. Provided that the fixed point comes with a finite number of ultraviolet-attractive (relevant) directions, this construction gives rise to a consistent quantum field theory which is as predictive as an ordinary, perturbatively renormalizable one. This opens up the exciting possibility of establishing quantum Einstein gravity as a fundamental theory of gravity, without introducing supersymmetry or extra dimensions, and solely based on quantization techniques that are known to work well for the other fundamental forces of nature. While the idea of gravity being asymptotically safe was proposed by Steven Weinberg more than 30 years ago [1], the technical tools for investigating this scenario only emerged during the last decade. Here a key role is played by the exact functional renormalization group equation for gravity, which allows the construction of non-perturbative approximate solutions for the RG-flow of the gravitational couplings. Most remarkably, all solutions constructed to date exhibit a suitable non-Gaussian fixed point, lending strong support to the asymptotic safety conjecture. Moreover, the functional renormalization group also provides indications that the central idea of a non-Gaussian fixed point providing a safe ultraviolet completion also carries over to more realistic scenarios where gravity is coupled to a suitable matter sector like the standard model. These theoretical successes also triggered a wealth of studies focusing on the consequences of asymptotic safety in a wide range of phenomenological applications covering the physics of black holes, early

  4. Correspondence passed between Einstein and Schroedinger; La correspondance entre Einstein et Schroedinger

    Energy Technology Data Exchange (ETDEWEB)

    Balibar, F. [Paris-7 Univ., 75 (France)

    1992-12-31

    The main points of the 26 year long correspondence between Einstein and Schroedinger are reviewed: from the de Broglie thesis and the Bose-Einstein statistics to the Schroedinger equation (1925-1926); from the EPR paradox to the cat parable (1935); a complete collaboration on unitary theories.

  5. NF-kappa B modulation is involved in celastrol induced human multiple myeloma cell apoptosis.

    Directory of Open Access Journals (Sweden)

    Haiwen Ni

    Full Text Available Celastrol is an active compound extracted from the root bark of the traditional Chinese medicine Tripterygium wilfordii Hook F. To investigate the effect of celastrol on human multiple myeloma cell cycle arrest and apoptosis and explore its molecular mechanism of action. The activity of celastrol on LP-1 cell proliferation was detected by WST-8 assay. The celastrol-induced cell cycle arrest was analyzed by flow cytometry after propidium iodide staining. Nuclear translocation of the nuclear factor kappa B (NF-κB was observed by fluorescence microscope. Celastrol inhibited cell proliferation of LP-1 myeloma cell in a dose-dependent manner with IC50 values of 0.8817 µM, which was mediated through G1 cell cycle arrest and p27 induction. Celastrol induced apoptosis in LP-1 and RPMI 8226 myeloma cells in a time and dose dependent manner, and it involved Caspase-3 activation and NF-κB pathway. Celastrol down-modulated antiapoptotic proteins including Bcl-2 and survivin expression. The expression of NF-κB and IKKa were decreased after celastrol treatment. Celastrol effectively blocked the nuclear translocation of the p65 subunit and induced human multiple myeloma cell cycle arrest and apoptosis by p27 upregulation and NF-kB modulation. It has been demonstrated that the effect of celastrol on NF-kB was HO-1-independent by using zinc protoporphyrin-9 (ZnPPIX, a selective heme oxygenase inhibitor. From the results, it could be inferred that celastrol may be used as a NF-kB inhibitor to inhibit myeloma cell proliferation.

  6. Lysophosphatidic acid induces expression of genes in human oral keratinocytes involved in wound healing.

    Science.gov (United States)

    Thorlakson, Hong Huynh; Engen, Stian Andre; Schreurs, Olav; Schenck, Karl; Blix, Inger Johanne Schytte

    2017-08-01

    Epithelial cells participate in wound healing by covering wounds, but also as important mediators of wound healing processes. Topical application of the phospholipid growth factor lysophosphatidic acid (LPA) accelerates dermal wound healing and we hypothesized that LPA can play a role in human oral wound healing through its effects on human oral keratinocytes (HOK). HOK were isolated from gingival biopsies and exposed to LPA. The LPA receptor profile, signal transduction pathways, gene expression and secretion of selected cytokines were analyzed. HOK expressed the receptors LPA 1 , LPA 5 and LPA 6 and LPA activated the ERK1/2, JNK and p38 intracellular pathways, substantiated by secretion of IL-6 and IL-8. The early (2h) and intermediate (6h) gene expression profiles of HOK after LPA treatment showed a wide array of regulated genes. The majority of the strongest upregulated genes were related to chemotaxis and inflammation, and became downregulated after 6h. At 6h, genes coding for factors involved in extracellular matrix remodeling and re-epithelialization became highly expressed. IL-36γ, not earlier known to be regulated by LPA, was strongly transcribed and translated but not secreted. After stimulation with LPA, HOK responded by regulating factors and genes that are essential in wound healing processes. As LPA is found in saliva and is released by activated cells after wounding, our results indicate that LPA has a favorable physiological role in oral wound healing. This may further point towards a beneficial role for application of LPA on oral surgical or chronic wounds. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Involvement of macrophage migration inhibitory factor and its receptor (CD74) in human breast cancer.

    Science.gov (United States)

    Richard, Vincent; Kindt, Nadège; Decaestecker, Christine; Gabius, Hans-Joachim; Laurent, Guy; Noël, Jean-Christophe; Saussez, Sven

    2014-08-01

    Macrophage migration inhibitory factor (MIF) and its receptor CD74 appear to be involved in tumorigenesis. We evaluated, by immunohistochemical staining, the tissue expression and distribution of MIF and CD74 in serial sections of human invasive breast cancer tumor specimens. The serum MIF level was also determined in breast cancer patients. We showed a significant increase in serum MIF average levels in breast cancer patients compared to healthy individuals. MIF tissue expression, quantified by a modified Allred score, was strongly increased in carcinoma compared to tumor-free specimens, in the cancer cells and in the peritumoral stroma, with fibroblasts the most intensely stained. We did not find any significant correlation with histoprognostic factors, except for a significant inverse correlation between tumor size and MIF stromal positivity. CD74 staining was heterogeneous and significantly decreased in cancer cells but increased in the surrounding stroma, namely in lymphocytes, macrophages and vessel endothelium. There was no significant variation according to classical histoprognostic factors, except that CD74 stromal expression was significantly correlated with triple-negative receptor (TRN) status and the absence of estrogen receptors. In conclusion, our data support the concept of a functional role of MIF in human breast cancer. In addition to auto- and paracrine effects on cancer cells, MIF could contribute to shape the tumor microenvironment leading to immunomodulation and angiogenesis. Interfering with MIF effects in breast tumors in a therapeutic perspective remains an attractive but complex challenge. Level of co-expression of MIF and CD74 could be a surrogate marker for efficacy of anti-angiogenic drugs, particularly in TRN breast cancer tumor.

  8. Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.

    Science.gov (United States)

    Syed, Deeba N; Lall, Rahul K; Chamcheu, Jean Christopher; Haidar, Omar; Mukhtar, Hasan

    2014-12-01

    The prognosis of malignant melanoma remains poor in spite of recent advances in therapeutic strategies for the deadly disease. Fisetin, a dietary flavonoid is currently being investigated for its growth inhibitory properties in various cancer models. We previously showed that fisetin inhibited melanoma growth in vitro and in vivo. Here, we evaluated the molecular basis of fisetin induced cytotoxicity in metastatic human melanoma cells. Fisetin treatment induced endoplasmic reticulum (ER) stress in highly aggressive A375 and 451Lu human melanoma cells, as revealed by up-regulation of ER stress markers including IRE1α, XBP1s, ATF4 and GRP78. Time course analysis indicated that the ER stress was associated with activation of the extrinsic and intrinsic apoptotic pathways. Fisetin treated 2-D melanoma cultures displayed autophagic response concomitant with induction of apoptosis. Prolonged treatment (16days) with fisetin in a 3-D reconstituted melanoma model resulted in inhibition of melanoma progression with significant apoptosis, as evidenced by increased staining of cleaved Caspase-3 in the treated constructs. However, no difference in the expression of autophagic marker LC-3 was noted between treated and control groups. Fisetin treatment to 2-D melanoma cultures resulted in phosphorylation and activation of the multifunctional AMP-activated protein kinase (AMPK) involved in the regulation of diverse cellular processes, including autophagy and apoptosis. Silencing of AMPK failed to prevent cell death indicating that fisetin induced cytotoxicity is mediated through both AMPK-dependent and -independent mechanisms. Taken together, our studies confirm apoptosis as the primary mechanism through which fisetin inhibits melanoma cell growth and that activation of both extrinsic and intrinsic pathways contributes to fisetin induced cytotoxicity.

  9. Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

    Science.gov (United States)

    Lin, C S; Boltz, R C; Blake, J T; Nguyen, M; Talento, A; Fischer, P A; Springer, M S; Sigal, N H; Slaughter, R S; Garcia, M L

    1993-03-01

    The role that potassium channels play in human T lymphocyte activation has been investigated by using specific potassium channel probes. Charybdotoxin (ChTX), a blocker of small conductance Ca(2+)-activated potassium channels (PK,Ca) and voltage-gated potassium channels (PK,V) that are present in human T cells, inhibits the activation of these cells. ChTX blocks T cell activation induced by signals (e.g., anti-CD2, anti-CD3, ionomycin) that elicit a rise in intracellular calcium ([Ca2+]i) by preventing the elevation of [Ca2+]i in a dose-dependent manner. However, ChTX has no effect on the activation pathways (e.g., anti-CD28, interleukin 2 [IL-2]) that are independent of a rise in [Ca2+]i. In the former case, both proliferative response and lymphokine production (IL-2 and interferon gamma) are inhibited by ChTX. The inhibitory effect of ChTX can be demonstrated when added simultaneously, or up to 4 h after the addition of the stimulants. Since ChTX inhibits both PK,Ca and PK,V, we investigated which channel is responsible for these immunosuppressive effects with the use of two other peptides, noxiustoxin (NxTX) and margatoxin (MgTX), which are specific for PK,V. These studies demonstrate that, similar to ChTX, both NxTX and MgTX inhibit lymphokine production and the rise in [Ca2+]i. Taken together, these data provide evidence that blockade of PK,V affects the Ca(2+)-dependent pathways involved in T lymphocyte proliferation and lymphokine production by diminishing the rise in [Ca2+]i that occurs upon T cell activation.

  10. Absence of linkage between MHC and a gene involved in susceptibility to human schistosomiasis

    Directory of Open Access Journals (Sweden)

    Chiarella J.M.

    1998-01-01

    Full Text Available Six hundred million people are at risk of infection by Schistosoma mansoni. MHC haplotypes have been reported to segregate with susceptibility to schistosomiasis in murine models. In humans, a major gene related to susceptibility/resistance to infection by S. mansoni (SM1 and displaying the mean fecal egg count as phenotype was detected by segregation analysis. This gene displayed a codominant mode of inheritance with an estimated frequency of 0.20-0.25 for the deleterious allele and accounted for more than 50% of the variance of infection levels. To determine if the SM1 gene segregates with the human MHC chromosomal region, we performed a linkage study by the lod score method. We typed for HLA-A, B, C, DR and DQ antigens in 11 informative families from an endemic area for schistosomiasis in Bahia, Brazil, by the microlymphocytotoxicity technique. HLA-DR typing by the polymerase chain reaction with sequence-specific primers (PCR-SSP and HLA-DQ were confirmed by PCR-sequence-specific oligonucleotide probes (PCR-SSOP. The lod scores for the different q values obtained clearly indicate that there is no physical linkage between HLA and SM1 genes. Thus, susceptibility or resistance to schistosomiasis, as defined by mean fecal egg count, is not primarily dependent on the host's HLA profile. However, if the HLA molecule plays an important role in specific immune responses to S. mansoni, this may involve the development of the different clinical aspects of the disease such as granuloma formation and development of hepatosplenomegaly.

  11. Solitons, Bose-Einstein condensation and superfluidity in He II

    International Nuclear Information System (INIS)

    Chela-Flores, J.; Ghassib, H.B.

    1985-09-01

    The analytic form of a wave propagating with a constant velocity and a permanent profile is inferred for a weakly interacting Bose gas, using an exact (rather than asymptotic) solution of the field equation of the self-consistent Hartree model. The significance of this approach is indicated, especially when realistic interatomic potentials are used. In addition, the general relation between solitons and Bose-Einstein condensation is underlined by invoking the profound insight recently acquired in studies of the quantum liquids involved in the living state. It is concluded that solitons may occur in He II, and may play a significant role in the phenomena of superfluidity. (author)

  12. Identification of new genes involved in human adipogenesis and fat storage.

    Directory of Open Access Journals (Sweden)

    Jörn Söhle

    Full Text Available Since the worldwide increase in obesity represents a growing challenge for health care systems, new approaches are needed to effectively treat obesity and its associated diseases. One prerequisite for advances in this field is the identification of genes involved in adipogenesis and/or lipid storage. To provide a systematic analysis of genes that regulate adipose tissue biology and to establish a target-oriented compound screening, we performed a high throughput siRNA screen with primary (preadipocytes, using a druggable siRNA library targeting 7,784 human genes. The primary screen showed that 459 genes affected adipogenesis and/or lipid accumulation after knock-down. Out of these hits, 333 could be validated in a secondary screen using independent siRNAs and 110 genes were further regulated on the gene expression level during adipogenesis. Assuming that these genes are involved in neutral lipid storage and/or adipocyte differentiation, we performed InCell-Western analysis for the most striking hits to distinguish between the two phenotypes. Beside well known regulators of adipogenesis and neutral lipid storage (i.e. PPARγ, RXR, Perilipin A the screening revealed a large number of genes which have not been previously described in the context of fatty tissue biology such as axonemal dyneins. Five out of ten axonemal dyneins were identified in our screen and quantitative RT-PCR-analysis revealed that these genes are expressed in preadipocytes and/or maturing adipocytes. Finally, to show that the genes identified in our screen are per se druggable we performed a proof of principle experiment using an antagonist for HTR2B. The results showed a very similar phenotype compared to knock-down experiments proofing the "druggability". Thus, we identified new adipogenesis-associated genes and those involved in neutral lipid storage. Moreover, by using a druggable siRNA library the screen data provides a very attractive starting point to identify anti

  13. Einstein's Revolutionary Light-Quantum Hypothesis

    Science.gov (United States)

    Stuewer, Roger H.

    2005-05-01

    The paper in which Albert Einstein proposed his light-quantum hypothesis was the only one of his great papers of 1905 that he himself termed ``revolutionary.'' Contrary to widespread belief, Einstein did not propose his light-quantum hypothesis ``to explain the photoelectric effect.'' Instead, he based his argument for light quanta on the statistical interpretation of the second law of thermodynamics, with the photoelectric effect being only one of three phenomena that he offered as possible experimental support for it. I will discuss Einstein's light-quantum hypothesis of 1905 and his introduction of the wave-particle duality in 1909 and then turn to the reception of his work on light quanta by his contemporaries. We will examine the reasons that prominent physicists advanced to reject Einstein's light-quantum hypothesis in succeeding years. Those physicists included Robert A. Millikan, even though he provided convincing experimental proof of the validity of Einstein's equation of the photoelectric effect in 1915. The turning point came after Arthur Holly Compton discovered the Compton effect in late 1922, but even then Compton's discovery was contested both on experimental and on theoretical grounds. Niels Bohr, in particular, had never accepted the reality of light quanta and now, in 1924, proposed a theory, the Bohr-Kramers-Slater theory, which assumed that energy and momentum were conserved only statistically in microscopic interactions. Only after that theory was disproved experimentally in 1925 was Einstein's revolutionary light-quantum hypothesis generally accepted by physicists---a full two decades after Einstein had proposed it.

  14. Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family.

    Directory of Open Access Journals (Sweden)

    Douglas R Boettner

    2008-01-01

    Full Text Available Entamoeba histolytica is the cause of amebic colitis and liver abscess. This parasite induces apoptosis in host cells and utilizes exposed ligands such as phosphatidylserine to ingest the apoptotic corpses and invade deeper into host tissue. The purpose of this work was to identify amebic proteins involved in the recognition and ingestion of dead cells. A member of the transmembrane kinase family, phagosome-associated TMK96 (PATMK, was identified in a proteomic screen for early phagosomal proteins. Anti-peptide affinity-purified antibody produced against PATMK demonstrated that it was a type I integral membrane protein that was expressed on the trophozoite surface, and that co-localized with human erythrocytes at the site of contact. The role of PATMK in erythrophagocytosis in vitro was demonstrated by: (i incubation of ameba with anti-PATMK antibodies; (ii PATMK mRNA knock-down using a novel shRNA expression system; and (iii expression of a carboxy-truncation of PATMK (PATMK(delta932. Expression of the carboxy-truncation of PATMK(delta932 also caused a specific reduction in the ability of E. histolytica to establish infection in the intestinal model of amebiasis, however these amebae retained the ability to cause hepatic abscesses when directly injected in the liver. In conclusion, PATMK was identified as a member of the TMK family that participates in erythrophagocytosis and is uniquely required for intestinal infection.

  15. Entamoeba histolytica phagocytosis of human erythrocytes involves PATMK, a member of the transmembrane kinase family.

    Science.gov (United States)

    Boettner, Douglas R; Huston, Christopher D; Linford, Alicia S; Buss, Sarah N; Houpt, Eric; Sherman, Nicholas E; Petri, William A

    2008-01-01

    Entamoeba histolytica is the cause of amebic colitis and liver abscess. This parasite induces apoptosis in host cells and utilizes exposed ligands such as phosphatidylserine to ingest the apoptotic corpses and invade deeper into host tissue. The purpose of this work was to identify amebic proteins involved in the recognition and ingestion of dead cells. A member of the transmembrane kinase family, phagosome-associated TMK96 (PATMK), was identified in a proteomic screen for early phagosomal proteins. Anti-peptide affinity-purified antibody produced against PATMK demonstrated that it was a type I integral membrane protein that was expressed on the trophozoite surface, and that co-localized with human erythrocytes at the site of contact. The role of PATMK in erythrophagocytosis in vitro was demonstrated by: (i) incubation of ameba with anti-PATMK antibodies; (ii) PATMK mRNA knock-down using a novel shRNA expression system; and (iii) expression of a carboxy-truncation of PATMK (PATMK(delta932)). Expression of the carboxy-truncation of PATMK(delta932) also caused a specific reduction in the ability of E. histolytica to establish infection in the intestinal model of amebiasis, however these amebae retained the ability to cause hepatic abscesses when directly injected in the liver. In conclusion, PATMK was identified as a member of the TMK family that participates in erythrophagocytosis and is uniquely required for intestinal infection.

  16. The exhausted CD4+CXCR5+ T cells involve the pathogenesis of human tuberculosis disease.

    Science.gov (United States)

    Bosco, Munyemana Jean; Wei, Ming; Hou, Hongyan; Yu, Jing; Lin, Qun; Luo, Ying; Sun, Ziyong; Wang, Feng

    2018-06-21

    The CD4 + CXCR5 + T cells have been previously established. However, their decreased frequency during tuberculosis (TB) disease is partially understood. The aim of this study was to explore the depletion of CD4 + CXCR5 + T cells in human TB. The frequency and function of CD4 + CXCR5 + T cells were evaluated in active TB (ATB) patients and healthy control (HC) individuals. The function of CD4 + CXCR5 + T cells was determined after blockade of inhibitory receptors. The frequency of CD4 + CXCR5 + T cells was decreased in ATB patients. The expression of activation markers (HLA-DR and ICOS) and inhibitory receptors (Tim-3 and PD-1) on CD4 + CXCR5 + T cells was increased in ATB group. TB-specific antigen stimulation induced higher expression of inhibitory receptors than phytohemagglutinin stimulation in ATB group. In contrast, TB antigen stimulation did not induce a significantly increased expression of IL-21 and Ki-67 on CD4 + CXCR5 + T cells. However, blockade of inhibitory receptors Tim-3 and PD-1 not only increased the frequency of CD4 + CXCR5 + T cells, but also restored their proliferation and cytokine secretion potential. An increased expression of inhibitory receptors involves the depletion of CD4 + CXCR5 + T cells, and blockade of inhibitory receptors can restore the function of CD4 + CXCR5 + T cells in ATB patients. Copyright © 2018. Published by Elsevier Ltd.

  17. Global Variation of Human Papillomavirus Genotypes and Selected Genes Involved in Cervical Malignancies.

    Science.gov (United States)

    Husain, R S Akram; Ramakrishnan, V

    2015-01-01

    Carcinoma of the cervix is ranked second among the top 5 cancers affecting women globally. Parallel to other cancers, it is also a complex disease involving numerous factors such as human papillomavirus (HPV) infection followed by the activity of oncogenes and environmental factors. The incidence rate of the disease remains high in developing countries due to lack of awareness, followed by mass screening programs, various socioeconomic issues, and low usage of preventive vaccines. Over the past 3 decades, extensive research has taken place in cervical malignancy to elucidate the role of host genes in the pathogenesis of the disease, yet it remains one of the most prevalent diseases. It is imperative that recent genome-wide techniques be used to determine whether carcinogenesis of oncogenes is associated with cervical cancer at the molecular level and to translate that knowledge into developing diagnostic and therapeutic tools. The aim of this study was to discuss HPV predominance with their genotype distribution worldwide, and in India, as well as to discuss the newly identified oncogenes related to cervical cancer in current scenario. Using data from various databases and robust technologies, oncogenes associated with cervical malignancies were identified and are explained in concise manner. Due to the advent of recent technologies, new candidate genes are explored and can be used as precise biomarkers for screening and developing drug targets. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Evolution of External Consultant Involvement in Human Resource Management in Eastern Europe (1990-2007

    Directory of Open Access Journals (Sweden)

    József Poór

    2015-03-01

    Full Text Available This paper aims to analyze the evolution of Human Resources (HR consulting in transitional economies of Eastern Europe (EE from the political changes till the economic crisis (2008. This article provides insights into the specific socio-economic environment and HR practice of the region.  Following Markham's model (1999 we analyze specific characteristics of four typical ways of external consultant involvement: informative-becnhmarking, design, change and organizational learning consulting.  in this region. In general, before the political changes at the end of the 1980's, in most EE countries , consulting service was redendered by sector  research institutes, controlled by the state or by the different minsitries. Consulting approach in EE countries  were predominant similar to the school of scientific management. HR consulting hardly existed that time. Since changes in the regime's consulting linked to privatization, firm restructuring, and development has been developing significantly in all countries of the region. HR consulting underwent a significant development in the region.

  19. Secrets of the old one Einstein, 1905

    CERN Document Server

    Bernstein, Jeremy

    2006-01-01

    In March 1905, at approximately eight week intervals, the Editor of the noted German physics journal, Annalen der Physik, received three hand-written manuscripts from a relatively unknown patent examiner in Bern, Switzerland. This patent examiner was the twenty-six year old Albert Einstein and the three papers would set the agenda for twentieth century physics. A fourth short paper was received in September 1905 and contained Einstein's derivation of the formula E=mc^2. These papers changed our lives in the twentieth century and beyond. While to a professional physicist the mathematics in these papers are quite straight forward, the ideas behind them are not. In fact, none of Einstein's contemporaries fully understood what he had done. In SECRETS OF THE OLD ONE: Einstein, 1905, renowned science writer Jeremy Bernstein makes these ideas accessible to a general reader with a limited background in mathematics. After reading this book, you will understand why 1905 is often designated as Einstein's miracle year.

  20. Functional connectivity profile of the human inferior frontal junction: involvement in a cognitive control network

    Directory of Open Access Journals (Sweden)

    Sundermann Benedikt

    2012-10-01

    Full Text Available Abstract Background The human inferior frontal junction area (IFJ is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control. As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functionally distinct location in the neuroimaging literature. While recent studies explicitly focused on the IFJ's anatomical organization and functional role as a single brain area, it is usually not explicitly denominated in studies on cognitive networks. However based on few analyses in small datasets constrained by specific a priori assumptions on its functional specialization, the IFJ has been postulated to be part of a cognitive control network. Goal of this meta-analysis was to establish the IFJ’s connectivity profile on a high formal level of evidence by aggregating published implicit knowledge about its co-activations. We applied meta-analytical connectivity modeling (MACM based on the activation likelihood estimation (ALE method without specific assumptions regarding functional specialization on 180 (reporting left IFJ activity and 131 (right IFJ published functional neuroimaging experiments derived from the BrainMap database. This method is based on coordinates in stereotaxic space, not on anatomical descriptors. Results The IFJ is significantly co-activated with areas in the dorsolateral and ventrolateral prefrontal cortex, anterior insula, medial frontal gyrus / pre-SMA, posterior parietal cortex, occipitotemporal junction / cerebellum, thalamus and putamen as well as language and motor areas. Results are corroborated by an independent resting-state fMRI analysis. Conclusions These results support the assumption that the IFJ is part of a previously described cognitive control network. They also highlight the involvement of subcortical structures in this system. A direct line is drawn from works on the functional

  1. Interprofessional student education: exchange program between Albert Einstein College of Medicine and Pacific College of Oriental Medicine.

    Science.gov (United States)

    Anderson, Belinda J; Herron, Patrick D; Downie, Sherry A; Myers, Daniel C; Milan, Felise B; Olson, Todd R; Kligler, Ben E; Sierpina, Victor S; Kreitzer, Mary Jo

    2012-01-01

    The growing popularity of complementary and alternative medicine (CAM), of which estimated 38% of adults in the United States used in 2007, has engendered changes in medical school curricula to increase students' awareness of it. Exchange programs between conventional medical schools and CAM institutions are recognized as an effective method of interprofessional education. The exchange program between Albert Einstein College of Medicine (Einstein, Yeshiva University) and Pacific College of Oriental Medicine, New York campus (PCOM-NY) is in its fifth year and is part of a broader relationship between the schools encompassing research, clinical training, interinstitutional faculty and board appointments, and several educational activities. The Einstein/PCOM-NY student education exchange program is part of the Einstein Introduction to Clinical Medicine Program and involves students from Einstein learning about Chinese medicine through a lecture, the experience of having acupuncture, and a four-hour preceptorship at the PCOM outpatient clinic. The students from PCOM learn about allopathic medicine training through an orientation lecture, a two-and-a-half-hour dissection laboratory session along side Einstein student hosts, and a tour of the clinical skills center at the Einstein campus. In the 2011/2012 offering of the exchange program, the participating Einstein and PCOM students were surveyed to assess the educational outcomes. The data indicate that the exchange program was highly valued by all students and provided a unique learning experience. Survey responses from the Einstein students indicated the need for greater emphasis on referral information, which has been highlighted in the literature as an important medical curriculum integrative medicine competency. Copyright © 2012 Elsevier Inc. All rights reserved.

  2. Ethics education in research involving human beings in undergraduate medicine curriculum in Brazil.

    Science.gov (United States)

    Novaes, Maria Rita Garbi; Guilhem, Dirce; Barragan, Elena; Mennin, Stewart

    2013-12-01

    The Brazilian national curriculum guidelines for undergraduate medicine courses inspired and influenced the groundwork for knowledge acquisition, skills development and the perception of ethical values in the context of professional conduct. The evaluation of ethics education in research involving human beings in undergraduate medicine curriculum in Brazil, both in courses with active learning processes and in those with traditional lecture learning methodologies. Curricula and teaching projects of 175 Brazilian medical schools were analyzed using a retrospective historical and descriptive exploratory cohort study. Thirty one medical schools were excluded from the study because of incomplete information or a refusal to participate. Active research for information from institutional sites and documents was guided by terms based on 69 DeCS/MeSH descriptors. Curriculum information was correlated with educational models of learning such as active learning methodologies, tutorial discussions with integrated curriculum into core modules, and traditional lecture learning methodologies for large classes organized by disciplines and reviewed by occurrence frequency of ethical themes and average hourly load per semester. Ninety-five medical schools used traditional learning methodologies. The ten most frequent ethical themes were: 1--ethics in research (26); 2--ethical procedures and advanced technology (46); 3--ethic-professional conduct (413). Over 80% of schools using active learning methodologies had between 50 and 100 hours of scheduled curriculum time devoted to ethical themes whereas more than 60% of traditional learning methodology schools devoted less than 50 hours in curriculum time to ethical themes. The data indicates that medical schools that employ more active learning methodologies provide more attention and time to ethical themes than schools with traditional discipline-based methodologies. Given the importance of ethical issues in contemporary medical

  3. Characterization of the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine

    Science.gov (United States)

    Kirkwood, L. C.; Nation, R. L.; Somogyi, A. A.

    1997-01-01

    Aims Using human liver microsomes from donors of the CYP2D6 poor and extensive metabolizer genotypes, the role of individual cytochromes P-450 in the oxidative metabolism of dihydrocodeine was investigated. Methods The kinetics of formation of N- and O-demethylated metabolites, nordihydrocodeine and dihydromorphine, were determined using microsomes from six extensive and one poor metabolizer and the effects of chemical inhibitors selective for individual P-450 enzymes of the 1A, 2A, 2C, 2D, 2E and 3A families and of LKM1 (anti-CYP2D6) antibodies were studied. Results Nordihydrocodeine was the major metabolite in both poor and extensive metabolizers. Kinetic constants for N-demethylation derived from the single enzyme Michaelis-Menten model did not differ between the two groups. Troleandomycin and erythromycin selectively inhibited N-demethylation in both extensive and poor metabolizers. The CYP3A inducer, α-naphthoflavone, increased N-demethylation rates. The kinetics of formation of dihydromorphine in both groups were best described by a single enzyme Michaelis-Menten model although inhibition studies in extensive metabolizers suggested involvement of two enzymes with similar Km values. The kinetic constants for O-demethylation were significantly different in extensive and poor metabolizers. The extensive metabolizers had a mean intrinsic clearance to dihydromorphine more than ten times greater than the poor metabolizer. The CYP2D6 chemical inhibitors, quinidine and quinine, and LKM1 antibodies inhibited O-demethylation in extensive metabolizers; no effect was observed in microsomes from a poor metabolizer. Conclusions CYP2D6 is the major enzyme mediating O-demethylation of dihydrocodeine to dihydromorphine. In contrast, nordihydrocodeine formation is predominantly catalysed by CYP3A. PMID:9431830

  4. New facets of the Einstein-Podolsky-Rosen paradox from elementary particle physics

    International Nuclear Information System (INIS)

    Home, Dipankar

    1988-01-01

    It is pointed out that the K 0 anti-K 0 and B 0 anti-B 0 systems provide a new arena for exploring the intricacies of the Einstein-Podolsky-Rosen (EPR) type example. This also provides clues for experimental discrimination between quantum mechanics and local realism. Consideration of the effect of CP non-invariance in the conext of such systems leads to the intriguing possibility, at least in principle, of an incompatibility between quantum mechanics and Einstein's locality condition at the statistical level. This calls for further investigations to clarify the subtleties involved. (author). 22 refs

  5. An Out-of-Math Experience: Einstein, Relativity, and the Developmental Mathematics Student.

    Science.gov (United States)

    Fiore, Greg

    2000-01-01

    Discusses Einstein's special relativity theory and some of the developmental mathematics involved. Presents motivational classroom materials used in discussing relative-motion problems, evaluating a radical expression, graphing with asymptotes, interpreting a graph, studying variation, and solving literal and radical equations. (KHR)

  6. Liver, spleen, pancreas and kidney involvement by human fascioliasis: imaging findings

    Directory of Open Access Journals (Sweden)

    Hekmatdoost Azita

    2004-08-01

    Full Text Available Abstract Background Fasciola hepatica primarily involves the liver, however in some exceptional situations other organs have been reported to be involved. The ectopic involvement is either a result of Parasite migration or perhaps eosinophilic reaction. Case presentation Here we report a known case of multiple myeloma who was under treatment with prednisolone and melphalan. He was infected by Fasciola hepatica, which involved many organs and the lesions were mistaken with metastatic ones. Discussion Presented here is a very unusual case of the disease, likely the first case involving the pancreas, spleen, and kidney, as well as the liver.

  7. De Sitter en Einstein. ‘Het lijkt mij dat Einstein hier een vergissing begaan heeft’

    Directory of Open Access Journals (Sweden)

    Jan Guichelaar

    2016-10-01

    Full Text Available De Sitter and EinsteinWillem de Sitter’s interest in gravity was based on his work on celestial mechanics, in particular on the four big moons of Jupiter. His work on cosmology was based on the general theory of relativity of Albert Einstein. De Sitter published in 1917, on request of Arthur Eddington to inform the English astronomers, a series of four articles in The Observatory and the Monthly Notices of the Royal Astronomical Society. Einstein developed his own cosmological models, containing mass. De Sitter found a different solution and described a universe without mass. Einstein could not accept De Sitter’s model and they ‘fought out’ two controversies in their correspondence. In theend Einstein had to confess De Sitter was mainly right in his criticisms. In 1932 Einstein and De Sitter published an article on a new model, the so-called Einstein-De Sitter Model of the universe. So, De Sitter was able to do fundamental work in classical celestial mechanics as well as in the new cosmological theories.

  8. The Chevreton tensor and Einstein-Maxwell spacetimes conformal to Einstein spaces

    International Nuclear Information System (INIS)

    Bergqvist, Goeran; Eriksson, Ingemar

    2007-01-01

    In this paper, we characterize the source-free Einstein-Maxwell spacetimes which have a trace-free Chevreton tensor. We show that this is equivalent to the Chevreton tensor being of pure radiation type and that it restricts the spacetimes to Petrov type N or O. We prove that the trace of the Chevreton tensor is related to the Bach tensor and use this to find all Einstein-Maxwell spacetimes with a zero cosmological constant that have a vanishing Bach tensor. Among these spacetimes we then look for those which are conformal to Einstein spaces. We find that the electromagnetic field and the Weyl tensor must be aligned, and in the case that the electromagnetic field is null, the spacetime must be conformally Ricci-flat and all such solutions are known. In the non-null case, since the general solution is not known on a closed form, we settle by giving the integrability conditions in the general case, but we do give new explicit examples of Einstein-Maxwell spacetimes that are conformal to Einstein spaces, and we also find examples where the vanishing of the Bach tensor does not imply that the spacetime is conformal to a C-space. The non-aligned Einstein-Maxwell spacetimes with vanishing Bach tensor are conformally C-spaces, but none of them are conformal to Einstein spaces

  9. q-deformed Einstein's model to describe specific heat of solid

    Science.gov (United States)

    Guha, Atanu; Das, Prasanta Kumar

    2018-04-01

    Realistic phenomena can be described more appropriately using generalized canonical ensemble, with proper parameter sets involved. We have generalized the Einstein's theory for specific heat of solid in Tsallis statistics, where the temperature fluctuation is introduced into the theory via the fluctuation parameter q. At low temperature the Einstein's curve of the specific heat in the nonextensive Tsallis scenario exactly lies on the experimental data points. Consequently this q-modified Einstein's curve is found to be overlapping with the one predicted by Debye. Considering only the temperature fluctuation effect(even without considering more than one mode of vibration is being triggered) we found that the CV vs T curve is as good as obtained by considering the different modes of vibration as suggested by Debye. Generalizing the Einstein's theory in Tsallis statistics we found that a unique value of the Einstein temperature θE along with a temperature dependent deformation parameter q(T) , can well describe the phenomena of specific heat of solid i.e. the theory is equivalent to Debye's theory with a temperature dependent θD.

  10. Einstein, Ethics and the Atomic Bomb

    Science.gov (United States)

    Rife, Patricia

    2005-03-01

    Einstein voiced his ethical views against war as well as fascism via venues and alliances with a variety of organizations still debated today. In 1939, he signed a letter to President Roosevelt (drafted by younger colleagues Szilard, Wigner and others) warning the U.S.government about the danger of Nazi Germany gaining control of uranium in the Belgian-controlled Congo in order to develop atomic weapons, based on the discovery of fission by Otto Hahn and Lise Meitner. In 1945, he became a member of the Princeton-based ``Emergency Committee for Atomic Scientists'' organized by Bethe, Condon, Bacher, Urey, Szilard and Weisskopf. Rare Einstein slides will illustrate Dr.Rife's presentation on Albert Einstein's philosophic and ethical convictions about peace, and public stance against war (1914-1950).

  11. Bose-Einstein condensation in microgravity.

    Science.gov (United States)

    van Zoest, T; Gaaloul, N; Singh, Y; Ahlers, H; Herr, W; Seidel, S T; Ertmer, W; Rasel, E; Eckart, M; Kajari, E; Arnold, S; Nandi, G; Schleich, W P; Walser, R; Vogel, A; Sengstock, K; Bongs, K; Lewoczko-Adamczyk, W; Schiemangk, M; Schuldt, T; Peters, A; Könemann, T; Müntinga, H; Lämmerzahl, C; Dittus, H; Steinmetz, T; Hänsch, T W; Reichel, J

    2010-06-18

    Albert Einstein's insight that it is impossible to distinguish a local experiment in a "freely falling elevator" from one in free space led to the development of the theory of general relativity. The wave nature of matter manifests itself in a striking way in Bose-Einstein condensates, where millions of atoms lose their identity and can be described by a single macroscopic wave function. We combine these two topics and report the preparation and observation of a Bose-Einstein condensate during free fall in a 146-meter-tall evacuated drop tower. During the expansion over 1 second, the atoms form a giant coherent matter wave that is delocalized on a millimeter scale, which represents a promising source for matter-wave interferometry to test the universality of free fall with quantum matter.

  12. Approximate radiative solutions of the Einstein equations

    International Nuclear Information System (INIS)

    Kuusk, P.; Unt, V.

    1976-01-01

    In this paper the external field of a bounded source emitting gravitational radiation is considered. A successive approximation method is used to integrate the Einstein equations in Bondi's coordinates (Bondi et al, Proc. R. Soc.; A269:21 (1962)). A method of separation of angular variables is worked out and the approximate Einstein equations are reduced to key equations. The losses of mass, momentum, and angular momentum due to gravitational multipole radiation are found. It is demonstrated that in the case of proper treatment a real mass occurs instead of a mass aspect in a solution of the Einstein equations. In an appendix Bondi's new function is given in terms of sources. (author)

  13. Static Einstein--Maxwell field equations

    International Nuclear Information System (INIS)

    Das, A.

    1979-01-01

    The static Einstein--Maxwell field equations are investigated in the presence of both electric and magnetic fields. The sources or bodies are assumed to be of finite size and to not affect the connectivity of the associated space. Furthermore, electromagnetic and metric fields are assumed to have reasonable differentiabilities. It is then proved that the electric and magnetic field vectors are constant multiples of one another. Moreover, the static Einstein--Maxwell equations reduce to the static magnetovac case. If, furthermore, the variational derivation of the Einstein--Maxwell equations is assumed, then both the total electric and magnetic charge of each body must vanish. As a physical consequence it is pointed out that if a suspended magnet be electrically charged then it must experience a purely general relativistic torque

  14. Restricted gravity: Abelian projection of Einstein's theory

    International Nuclear Information System (INIS)

    Cho, Y.M.

    2013-01-01

    Treating Einstein's theory as a gauge theory of Lorentz group, we decompose the gravitational connection Γμ into the restricted connection made of the potential of the maximal Abelian subgroup H of Lorentz group G and the valence connection made of G/H part of the potential which transforms covariantly under Lorentz gauge transformation. With this we show that Einstein's theory can be decomposed into the restricted gravity made of the restricted connection which has the full Lorentz gauge invariance which has the valence connection as gravitational source. The decomposition shows the existence of a restricted theory of gravitation which has the full general invariance but is much simpler than Einstein's theory. Moreover, it tells that the restricted gravity can be written as an Abelian gauge theory,

  15. Partially massless graviton on beyond Einstein spacetimes

    Science.gov (United States)

    Bernard, Laura; Deffayet, Cédric; Hinterbichler, Kurt; von Strauss, Mikael

    2017-06-01

    We show that a partially massless graviton can propagate on a large set of spacetimes which are not Einstein spacetimes. Starting from a recently constructed theory for a massive graviton that propagates the correct number of degrees of freedom on an arbitrary spacetime, we first give the full explicit form of the scalar constraint responsible for the absence of a sixth degree of freedom. We then spell out generic conditions for the constraint to be identically satisfied, so that there is a scalar gauge symmetry which makes the graviton partially massless. These simplify if one assumes that spacetime is Ricci symmetric. Under this assumption, we find explicit non-Einstein spacetimes (some, but not all, with vanishing Bach tensors) allowing for the propagation of a partially massless graviton. These include in particular the Einstein static Universe.

  16. Classes of exact Einstein Maxwell solutions

    Science.gov (United States)

    Komathiraj, K.; Maharaj, S. D.

    2007-12-01

    We find new classes of exact solutions to the Einstein Maxwell system of equations for a charged sphere with a particular choice of the electric field intensity and one of the gravitational potentials. The condition of pressure isotropy is reduced to a linear, second order differential equation which can be solved in general. Consequently we can find exact solutions to the Einstein Maxwell field equations corresponding to a static spherically symmetric gravitational potential in terms of hypergeometric functions. It is possible to find exact solutions which can be written explicitly in terms of elementary functions, namely polynomials and product of polynomials and algebraic functions. Uncharged solutions are regainable with our choice of electric field intensity; in particular we generate the Einstein universe for particular parameter values.

  17. Modified Einstein and Navier–Stokes Equations

    Science.gov (United States)

    Bulyzhenkov, I. É.

    2018-05-01

    The appearance of inertial rest mass-energy is associated with the kinematic slowing-down of time and with the vortex state of the elementary massive space with zero integral of its kinetic and potential energies. An analog of the Einstein equation is found for moving densities of a non-empty metric space in the concept of the Einstein-Infeld material field. The vector consequences of this tensor equation for a metric medium of overlapping elementary carriers of continuous mass-energies allow us to modify the Navier-Stokes equation under inertial motion of the matter of the nonlocal field in the nonrelativistic limit. The nonlocality of massenergy generates kinematic accelerations of feedback to Newtonian acceleration, which impedes asymptotic divergence of energy fluxes. Stabilization of inertial media by dynamic Bernoulli pressure corresponds to nonlocal self-organization of Einstein-Infeld non-empty space and invalidates Newtonian localization of masses in empty space.

  18. Einstein and interpretation of quantum field theory

    International Nuclear Information System (INIS)

    Kashlyun, F.

    1982-01-01

    The main problems of the quantum theory, the basis of which was laid by Planck in 1900 as a result of the discovery of elementary quantum of action, are examined. The most important Einstein contributions to the quantum theory are enumerated. The Einstein work about the light quanta, proved wave-particle dualism, stated one of the most complicated problems to the physics. The work on the specific heat capacity of solids shows that the quantum theory should be beyond the limits of the narrow range of the problems on black radiation. The works on the equilibrium of radiation have convincingly demonstrates statistical character of the radiation processes and have marked the way to Heizenberg form of the quantum mechanics. Einstein generalized the idea of wave-particle dualism to the ordinary gas. It helped to prepare the Schroedinger form of quantum mechanics

  19. Modified Einstein and Navier-Stokes Equations

    Science.gov (United States)

    Bulyzhenkov, I. É.

    2018-05-01

    The appearance of inertial rest mass-energy is associated with the kinematic slowing-down of time and with the vortex state of the elementary massive space with zero integral of its kinetic and potential energies. An analog of the Einstein equation is found for moving densities of a non-empty metric space in the concept of the Einstein-Infeld material field. The vector consequences of this tensor equation for a metric medium of overlapping elementary carriers of continuous mass-energies allow us to modify the Navier-Stokes equation under inertial motion of the matter of the nonlocal field in the nonrelativistic limit. The nonlocality of massenergy generates kinematic accelerations of feedback to Newtonian acceleration, which impedes asymptotic divergence of energy fluxes. Stabilization of inertial media by dynamic Bernoulli pressure corresponds to nonlocal self-organization of Einstein-Infeld non-empty space and invalidates Newtonian localization of masses in empty space.

  20. 34 CFR 97.118 - Applications and proposals lacking definite plans for involvement of human subjects.

    Science.gov (United States)

    2010-07-01

    ... Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.118 Applications and proposals lacking definite plans..., or contracts are submitted to departments or agencies with the knowledge that subjects may be...

  1. [The meeting of Einstein with Cajal (Madrid, 1923): a lost tide of fortune].

    Science.gov (United States)

    Montes-Santiago, J

    The year 2005 was the centennial year of the Albert Einstein's transcendental works that changed forever the humans thoughts on the universe. It is also celebrated the 50th anniversary of his death. It was proclaimed 'World Year of Physics' and a multiplicity of celebrations have exhaustively analyzed Einstein's cardinals contributions. However, among these, the meeting of Einstein with another titanic of science, Santiago Ramon y Cajal, has passed some unnoticed. In this study the circumstances of this meeting are evoked. The parallelisms between the lives of both prominent figures awarded with the Nobel Prize are highlighted. They are the 'classic' authors most widely cited in the current scientific literature. The events and persons who made possible that shining but forgotten interview are detailed. Such a meeting took place in Madrid, on the occasion of the Einstein's trip to Spain in 1923. That travel exceeded his primary scientific nature, reaching the category of a social phenomenon and was widely covered by the printed mass media at that time. Finally, the curious coincidence of the invocation of Cajal's theories to justify the genius of the German physicist nearly 75 years after their meeting is mentioned. Although it was a brief meeting and the circumstances surrounding it largely unknown, it produced a great impression to Einstein and constitutes a supreme instant in the history of the 20th century.

  2. Einstein's enigma or black holes in my bubble bath

    CERN Document Server

    Vishveshwara, C V

    2006-01-01

    A funny rendition of the story of gravitation theory from the early historic origins to the developments in astrophysics, focusing on Albert Einstein''s theory of general relativity and black-hole physics.

  3. Fermilab | Science | Questions for the Universe | Einstein's Dream of

    Science.gov (United States)

    newsletter Einstein's Dream of Unified Forces In this Section: Einstein's Dream of Unified Forces Are there dream of an ultimate explanation for everything from the tiniest quanta of particle physics to the

  4. Quantum Interactive Dualism: The Libet and Einstein-Podolsky-RosenCausal Anomalies

    Energy Technology Data Exchange (ETDEWEB)

    Stapp, Henry P.

    2006-02-20

    The "free will" data of Benjamin Libet and the predictionsof quantum theory considered by Einstein, Podolsky,and Rosen, both posepuzzles within aconceptual framework that, simultaneously, is compatiblewith the theory of relativity and allows human subjects to freely choosehow they will act. The quantum theoretic resolutions of these puzzles aredescribed.

  5. Quantum Interactive Dualism: The Libet and Einstein-Podolsky-Rosen Causal Anomalies

    International Nuclear Information System (INIS)

    Stapp, Henry P.

    2006-01-01

    The 'free will' data of Benjamin Libet and the predictions of quantum theory considered by Einstein, Podolsky, and Rosen, both pose puzzles within a conceptual framework that, simultaneously, is compatible with the theory of relativity and allows human subjects to freely choose how they will act. The quantum theoretic resolutions of these puzzles are described

  6. Einstein une biographie dessinée

    CERN Document Server

    Maier, Corinne

    2015-01-01

    « Je m'appelle Albert Einstein. En voulant comprendre l'univers, j'ai libéré des forces de destruction terrifiantes. Mais il faut continuer à chercher le grand secret du cosmos. » Albert Einstein (1879-1955) est un immense génie devenu, sans le vouloir, une star de la science. Avec ses théories de la relativité restreinte puis de la relativité générale, il a radicalement transformé nos vies. Voici le récit de son existence passionnée et de ses contributions fondamentales.

  7. Einstein and general relativity: historical perspectives

    International Nuclear Information System (INIS)

    Chandrasekhar, S.

    1978-01-01

    The place of Einstein in 20th-century physics is discussed. The basic ideas that led Einstein to his theory of gravitation by the sheer power of speculative thought are described in the most general terms. The prediction of the bending of starlight by the Sun and the eclipse expedition of 1919 are recounted. The author feels that ''the general theory of relativity is incredibly rich in its content;...one finds a glittering face at almost every turn.'' The prediction of black holes by general relativity is noted

  8. Resonances for coupled Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Haroutyunyan, H.L.; Nienhuis, G.

    2004-01-01

    The properties of a Bose-Einstein condensate in a two-well potential can be manipulated by periodic modulation of the potential parameters. We study the effects arising from modulating the barrier height and the difference in well depth. At certain modulation frequencies the system exhibits resonances, which may show up in an enhancement of the tunneling rate between the wells. Resonances can be used to control the particle distribution over the wells. Some of the effects occurring in the two-well system also arise for a Bose-Einstein condensate in an optical lattice

  9. Mathematical implications of Einstein-Weyl causality

    International Nuclear Information System (INIS)

    Borchers, H.J.; Sen, R.N.

    2006-01-01

    The present work is the first systematic attempt at answering the following fundamental question: what mathematical structures does Einstein-Weyl causality impose on a point-set that has no other previous structure defined on it? The authors propose an axiomatization of Einstein-Weyl causality (inspired by physics), and investigate the topological and uniform structures that it implies. Their final result is that a causal space is densely embedded in one that is locally a differentiable manifold. The mathematical level required of the reader is that of the graduate student in mathematical physics. (orig.)

  10. Actuality of the Einstein theory of gravitation

    International Nuclear Information System (INIS)

    Ivanenko, D.D.

    1982-01-01

    Problems of actuality of the Einstein theory of gravitation are lightened. The great Einstein theory of gravitation is shown to remain a reliable base of understanding of modern physical world pattern and its inevitable further inexhaustible precising. The main GRT difficulties are enumirated: determination of reference systems, presence of singularities in the theory, absence of consistent determination of the gravity energy, impossibility of accounting the relations between atomic, gravitational and cosmological characteristics. The attention is paid to gauge, twistor problems and to unified interaction theory. The great contribution of the soviet science in the theory of gravitation is stressed

  11. Beyond Einstein: Exploring the Extreme Universe

    Science.gov (United States)

    Barbier, Louis M.

    2005-01-01

    This paper will give an overview of the NASA Universe Division Beyond Einstein program. The Beyond Einstein program consists of a series of exploratory missions to investigate some of the most important and pressing problems in modern-day astrophysics - including searches for Dark Energy and studies of the earliest times in the universe, during the inflationary period after the Big Bang. A variety of new technologies are being developed both in the science instrumentation these missions will carry and in the spacecraft that will carry those instruments.

  12. Bohr vs. Einstein: Fortolkning af kvantemekanikken

    DEFF Research Database (Denmark)

    Andersen, Christian Kraglund; Wade, Andrew Christopher James

    2013-01-01

    Siden 1913, da Bohr fremlagde sin kvantemekaniske model for atomet, har fysikere diskuteret, hvordan kvan- temekanikken skal fortolkes. Specielt aktive i denne diskussion var Bohr og Einstein, som havde modstridende opfattelser af, hvordan kvantemekanikken skulle forstås. Kan katte være både...... levende og døde på samme tid? Kan vi teleportere partikler mellem Månen og Jorden? Disse spørgsmål, og mange flere, forsøgte Bohr og Einstein at besvare, og det vil vi ligeledes i denne artikel....

  13. Einstein and a century of time

    Science.gov (United States)

    Raine, D. J.

    2005-09-01

    In a world overabundant in information, a subject is defined by its iconography. Physics is the falling apple, the planetary atom, the laser, the mushroom cloud and the image of the later Einstein - images that represent, respectively, gravity, atomic theory, quantum theory, mass-energy and the scientist who had a hand in all four. It is therefore appropriate that World Year of Physics is called Einstein Year in the UK. Of course one can argue that progress in science depends on the contributions of many people; that there are other geniuses in physics, even some colourful personalities. Nevertheless there are fundamental reasons why Einstein's early achievements stand out even in their company. When at last the thought came to him that 'time itself was suspect', Einstein had found a new insight into the nature of the physical universe. It is this: that the universal properties of material objects tell us about the nature of space and time, and it is through these properties, not philosophical logic or common sense, that we discover the structure of spacetime. The later Einstein turned this successful formula on its head and sought to use the properties of spacetime to define those of material objects, thereby seeking to abolish matter entirely in favour of geometry. Before I introduce this special feature of European Journal of Physics I will say a few words about what is not here. Like all great geniuses Einstein can be seen as the climax of what went before him and the initiation of what was to follow. Looking back we can see the influence of Mach's positivism, according to which the role of science is to relate observations to other observations; hence only observations can tell us what is 'real'. But Einstein also grew up with the family electromechanical businesses, which testifies to the reality of the Maxwellian electromagnetic fields: thus only theory can tell us what is real! As is well known, Einstein himself refused to accept the full consequences of

  14. On Einstein's kinematics and his derivation of Lorentz transformation equations

    International Nuclear Information System (INIS)

    Gulati, Shobha; Gulati, S.P.

    1981-01-01

    Recently the present authors have claimed that Einstein's historic derivation of 1905 of Lorentz transformation equations is a 'howler' - a correct result achieved through some incorrect steps. In the present contribution, this howler is fully resolved. Incidently, Einstein's kinematical considerations are found to be void of any new definitional elements or conventionality as unjustifiably claimed by Einstein and some other scientists. (author)

  15. Ethic and Evolution in Boltzmann's and Einstein's Thought

    International Nuclear Information System (INIS)

    Broda, E.

    1980-01-01

    In physics and to a large extent in epistomology, Einstein was the natural successor to Boltzmann. But while Boltzmann was an ardent evolutionist, Einstein cared little for biology. Boltzmann applied Darwinian principles also to ethics, but remained aloof from politics. In contrast, Einstein's morality, though expressed in magnificent and selfless activity, lacked a firm theoretical basis. (author)

  16. Ethic and Evolution in Boltzmann's and Einstein's Thought

    Energy Technology Data Exchange (ETDEWEB)

    Broda, E.

    1980-07-01

    In physics and to a large extent in epistomology, Einstein was the natural successor to Boltzmann. But while Boltzmann was an ardent evolutionist, Einstein cared little for biology. Boltzmann applied Darwinian principles also to ethics, but remained aloof from politics. In contrast, Einstein's morality, though expressed in magnificent and selfless activity, lacked a firm theoretical basis. (author)

  17. Einstein 1905-1955: His Approach to Physics

    Science.gov (United States)

    Damour, Thibault

    We review Einstein's epistemological conceptions, and indicate their philosophical roots. The particular importance of the ideas of Hume, Kant, Mach, and Poincaré is highlighted. The specific characteristics of Einstein's approach to physics are underlined. Lastly, we consider the practical application of Einstein's methodological principles to the two theories of relativity, and to quantum theory. We emphasize a Kantian approach to quantum theory.

  18. Die Leben Einsteins eine Reise durch die Geschichte der Physik

    CERN Document Server

    Fiami

    2005-01-01

    Jeder kennt die Namen Einstein, Newton oder Galilei. aber was weiss man über sie? Hier ein Porträt Einsteins anhand von sechs Meilensteinen aus der Geschichte der Physik. Einstein tritt auf als Protagonist in verschiedenen Epochen und bei verschiedenen Entdeckungen, die die Welt verändert haben.

  19. Cellular and Molecular Effect of MEHP Involving LXRα in Human Fetal Testis and Ovary

    OpenAIRE

    Muczynski, Vincent; Lecureuil, Charlotte; Messiaen, Sébastien; Guerquin, Marie-Justine; N’Tumba-Byn, Thierry; Moison, Delphine; Hodroj, Wassim; Benjelloun, Hinde; Baijer, Jan; Livera, Gabriel; Frydman, René; Benachi, Alexandra; Habert, René; Rouiller-Fabre, Virginie

    2012-01-01

    Background Phthalates have been shown to have reprotoxic effects in rodents and human during fetal life. Previous studies indicate that some members of the nuclear receptor (NR) superfamilly potentially mediate phthalate effects. This study aimed to assess if expression of these nuclear receptors are modulated in the response to MEHP exposure on the human fetal gonads in vitro. Methodology/Principal Findings Testes and ovaries from 7 to 12 gestational weeks human fetuses were exposed to 10−4M...

  20. 78 FR 10538 - Protections for Subjects in Human Research Involving Pesticides

    Science.gov (United States)

    2013-02-14

    ... involving intentional exposure of children or of pregnant or nursing women, unless relying on the data is crucial to a decision that would impose a more stringent regulatory restriction that would improve... itself to conduct or support any research involving intentional exposure of pregnant or nursing women or...

  1. User involvement in the design of human-computer interactions: some similarities and differences between design approaches

    NARCIS (Netherlands)

    Bekker, M.M.; Long, J.B.

    1998-01-01

    This paper presents a general review of user involvement in the design of human-computer interactions, as advocated by a selection of different approaches to design. The selection comprises User-Centred Design, Participatory Design, Socio-Technical Design, Soft Systems Methodology, and Joint

  2. Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)

    NARCIS (Netherlands)

    Reinen, Jelle; Nematollahi, Leyla; Fidder, Alex; Vermeulen, Nico P E; Noort, Daan; Commandeur, Jan N M

    2015-01-01

    Tri-ortho-cresyl phosphate (ToCP) is a multipurpose organophosphorus compound that is neurotoxic and suspected to be involved in aerotoxic syndrome in humans. It has been reported that not ToCP itself but a metabolite of ToCP, namely, 2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one (CBDP), may

  3. 40 CFR 26.1203 - Prohibition of research involving intentional exposure of any human subject who is a pregnant...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Prohibition of research involving intentional exposure of any human subject who is a pregnant woman (and therefore her fetus), a nursing woman, or a child. 26.1203 Section 26.1203 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL...

  4. 40 CFR 26.203 - Prohibition of research conducted or supported by EPA involving intentional exposure of any human...

    Science.gov (United States)

    2010-07-01

    ... her fetus), a nursing woman, or child. 26.203 Section 26.203 Protection of Environment ENVIRONMENTAL... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Prohibition of research conducted or... Involving Intentional Exposure of Human Subjects who are Children or Pregnant or Nursing Women § 26.203...

  5. You err, Einstein.. Newton, Einstein, Heisenberg, and Feynman discuss quantum physics

    International Nuclear Information System (INIS)

    Fritzsch, Harald

    2008-01-01

    Harald Fritzsch and his star physicists Einstein, Heisenberg, and Feynman explain the central concept of nowadays physics, quantum mechanics, without it nothing goes in modern world. And the great Isaac newton puts the questions, which all would put

  6. Involvement of Higher Education in Building Human Resources Character in the Era of Globalization

    Science.gov (United States)

    Ishomuddin

    2015-01-01

    In general, the objectives of this study were to explain the role played by universities in improving its human resources are office holders, lecturers, and students, explain the program what is being done related to the improvement of human resources, and explains the non-academic program to support the implementation of a program that has been…

  7. Einstein and Infeld, Seen Through Their Correspondence

    International Nuclear Information System (INIS)

    Stachel, J.

    1999-01-01

    On the basis of material in the Einstein Archive and Infeld's writings, the story of their relationship between 1920 and 1955 is reconstructed. While the scientific side of their early contacts and later collaboration is discussed, the major emphasis is placed on the development of their personal relations, and their comments on various social, cultural and political questions. (author)

  8. The Excellence of Einstein's Theory of Gravitation.

    Science.gov (United States)

    Dirac, P. A. M.

    1979-01-01

    This article is adapted from a presentation made in 1978 at the symposium on the Impact of Modern Scientific Ideas on Society organized by UNESCO in Ulm, West Germany. It discusses Einstein's theory of gravitation and how it started a new line of activity for physicists. (HM)

  9. Einstein's lessons for energy accounting in LCA

    NARCIS (Netherlands)

    Frischknccht, Rolf; Heijungs, Reinout; Hofstetter, Patrick

    1998-01-01

    The role and meaning of accounting for energy, including feedstock energy, is reviewed in connection to Einstein's special theory of relativity. It is argued that there is only one unambiguous interpretation of the term energy-content: The one that corresponds to mc2. The implications for life cycle

  10. Einstein and the Special Theory of Relativity

    Indian Academy of Sciences (India)

    some detail how Einstein evolved this theory and get a glimpse of his unique ... The Principle of Relativity: The laws of physics are the same in all inertial frames. .... ing on the railway platform will see them occur at different places. However ...

  11. Conformal anomalies and the Einstein field equations

    Energy Technology Data Exchange (ETDEWEB)

    Godazgar, Hadi [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Mühlenberg 1, D-14476 Potsdam (Germany); Meissner, Krzysztof A. [Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warsaw (Poland); Nicolai, Hermann [Max-Planck-Institut für Gravitationsphysik (Albert-Einstein-Institut), Mühlenberg 1, D-14476 Potsdam (Germany)

    2017-04-28

    We compute corrections to the Einstein field equations which are induced by the anomalous effective actions associated to the type A conformal anomaly, both for the (non-local) Riegert action, as well as for the local action with dilaton. In all cases considered we find that these corrections can be very large.

  12. [Albert Einstein and his abdominal aortic aneurysm].

    Science.gov (United States)

    Cervantes Castro, Jorge

    2011-01-01

    The interesting case of Albert Einstein's abdominal aortic aneurysm is presented. He was operated on at age 69 and, finding that the large aneurysm could not be removed, the surgeon elected to wrap it with cellophane to prevent its growth. However, seven years later the aneurysm ruptured and caused the death of the famous scientist.

  13. Albert Einstein, guide spirituel du CERN

    CERN Multimedia

    Sandraz, Raphaël

    2005-01-01

    The year 2005, proclaimed "World year of Physics" by UNESCO, dedicates the 100th anniversary of the theory of relativity and the 50th anniversary of the death of his discoverer: Albert Einstein. The CERN in Geneva applies every day his theories (1 page)

  14. Albert Einstein and the Quantum Riddle

    Science.gov (United States)

    Lande, Alfred

    1974-01-01

    Derives a systematic structure contributing to the solution of the quantum riddle in Einstein's sense by deducing quantum mechanics from the postulates of symmetry, correspondence, and covariance. Indicates that the systematic presentation is in agreement with quantum mechanics established by Schroedinger, Born, and Heisenberg. (CC)

  15. On Einstein's opponents, and other crackpots

    NARCIS (Netherlands)

    van Dongen, J.A.E.F.

    2010-01-01

    Einsteins Gegner: Die öffentliche Kontroverse um die Relativitätstheorie in den 1920er Jahren, Milena Wazeck. Campus Verlag, pp. 429, EUR 39.90. ISBN: 978-3593389141 “This world is a strange madhouse. Currently, every coachman and every waiter is debating whether relativity theory is correct. Belief

  16. The Foundations of Einstein's Theory of Gravitation

    Science.gov (United States)

    Freundlich, Erwin; Brose, Translated by Henry L.; Einstein, Preface by Albert; Turner, Introduction by H. H.

    2011-06-01

    Introduction; 1. The special theory of relativity as a stepping-stone to the general theory of relativity; 2. Two fundamental postulates in the mathematical formulation of physical laws; 3. Concerning the fulfilment of the two postulates; 4. The difficulties in the principles of classical mechanics; 5. Einstein's theory of gravitation; 6. The verification of the new theory by actual experience; Appendix; Index.

  17. Compton's Kinematics and Einstein - Ehrenfest's radiation theory

    International Nuclear Information System (INIS)

    Barranco, A.V.; Franca, H.M.

    1988-09-01

    The Compton Kinematic relations are obtained from entirely classical arguments, that is, without the corpuscular concept of the photon. The calculations are nonrelativistic and result from Einstein and Ehrenfest's radiation theory modified in order to introduce the effects of the classical zero-point fileds characteristic of Stochastic Electrodynamics. (author) [pt

  18. Soliton resonance in bose-einstein condensate

    Science.gov (United States)

    Zak, Michail; Kulikov, I.

    2002-01-01

    A new phenomenon in nonlinear dispersive systems, including a Bose-Einstein Condensate (BEC), has been described. It is based upon a resonance between an externally induced soliton and 'eigen-solitons' of the homogeneous cubic Schrodinger equation. There have been shown that a moving source of positive /negative potential induces bright /dark solitons in an attractive / repulsive Bose condensate.

  19. Traffic disruption route Einstein near building 170

    CERN Multimedia

    A Lopez - TS/CE

    2005-01-01

    The TS/CE Group informs you that, for the duration of the work at Building 170, there may be some disruption to traffic on route Einstein in the vicinity of Building 170. The work is due to take place from the 14th to 18th February. For more information, please contact 165029. A. Lopez TS/CE

  20. Skyrmion physics in Bose-Einstein ferromagnets

    NARCIS (Netherlands)

    Al Khawaja, U.; Stoof, H.T.C.

    2001-01-01

    We show that a ferromagnetic Bose-Einstein condensate has not only line-like vortex excitations, but in general, also allows for pointlike topological excitations, i.e., skyrmions. We discuss the thermodynamic stability and the dynamic properties of these skyrmions for both spin-1/2 and

  1. Einstein and the Special Theory of Relativity

    Indian Academy of Sciences (India)

    picture books for children. Supurna Sinha ... no contact with other contemporary great thinkers. This isolation ... do not remember if I knew of it at all when I wrote my first paper .... words of R S Shankland: "I asked Professor Einstein how long.

  2. Albert Einstein the roads to pacifism

    CERN Document Server

    Anta, Claudio Giulio

    2017-01-01

    Albert Einstein (1879-1955) is universally known as the father of the theory of relativity; however, he was also one of the most eminent pacifists of the first half of the twentieth century. Through his active, pragmatic and nuanced breed of pacifism, he sought to confront the dilemmas and problems of his time.

  3. Albert Einstein: Radical Pacifist and Democrat

    Science.gov (United States)

    Jayaraman, T.

    We draw attention here to the radical political grounding of Einstein's pacifism. We also drescribe some less commonly known aspects of his commitment to civil liberties, particularly in the context of the anti-l hysteria and anti-racism current in the United States of the late 1940s and 1950s. We also examine briefly his views on socialism.

  4. Bose-Einstein correlations between kaons

    International Nuclear Information System (INIS)

    Akesson, T.; Batley, R.; Breuker, H.; Dam, P.; Eidelman, S.; Fabian, C.W.; Frandsen, P.; Goerlach, U.; Heck, B.; Hilke, H.J.; Jeffreys, P.; Kalinovsky, A.; Kesseler, G.; Lans, J. van der; Lindsay, J.; Markou, A.; Mjoernmark, U.; Nielsen, B.S.; Olsen, L.H.; Rosselet, L.; Rosso, E.; Rudge, A.; Schindler, R.; Willis, W.J.; Witzeling, W.; Albrow, M.G.; Cockerill, D.; Evans, W.M.; Gibson, M.; Hiddleston, J.; MacCubbin, N.A.; Williamson, J.; Benary, O.; Dagan, S.; Lissauer, D.; Oren, Y.; Boeggild, H.; Botner, O.; Dahl-Jensen, E.; Dahl-Jensen, I.; Damgaard, G.; Hansen, K.H.; Hooper, J.; Moeller, R.; Brody, H.; Frankel, S.; Frati, W.; Molzon, W.; Vella, E.; Zajc, W.A.; Burkert, V.; Carter, J.R.; Cecil, P.; Chung, S.U.; Gordon, H.; Ludlam, T.; Winik, M.; Woody, C.; Cleland, W.E.; Kroeger, R.; Sullivan, M.; Thompson, J.A.

    1985-01-01

    Bose-Einstein correlations between identical charged kaons are observed in αα, pp, and panti p collisions at the CERN Intersecting Storage Rings. The average radial extension of the K-emitting region is found to be (2.4+-0.9) fm. (orig.)

  5. Type III Einstein-Yang-Mills solutions

    NARCIS (Netherlands)

    Fuster, A.; Holten, van J.W.

    2005-01-01

    Exact solutions of Einstein equations have always attracted much attention. It is somewhat surprising to find exact solutions of such nonlinear equations. Many of them were collected in the by now classic book by Kramer et al. which has recently been revised [1]. Among others one finds the

  6. Einstein Slew Survey: Data analysis innovations

    Science.gov (United States)

    Elvis, Martin S.; Plummer, David; Schachter, Jonathan F.; Fabbiano, G.

    1992-01-01

    Several new methods were needed in order to make the Einstein Slew X-ray Sky Survey. The innovations which enabled the Slew Survey to be done are summarized. These methods included experimental approach to large projects, parallel processing on a LAN, percolation source detection, minimum action identifications, and rapid dissemination of the whole data base.

  7. The Einstein All-Sky Slew Survey

    Science.gov (United States)

    Elvis, Martin S.

    1992-01-01

    The First Einstein IPC Slew Survey produced a list of 819 x-ray sources, with f(sub x) approximately 10(exp -12) - 10(exp -10) erg/sq cm s and positional accuracy of approximately 1.2 feet (90 percent radius). The aim of this program was to identify these x-ray sources.

  8. Einstein Observations of Galactic supernova remnants

    Science.gov (United States)

    Seward, Frederick D.

    1990-01-01

    This paper summarizes the observations of Galactic supernova remnants with the imaging detectors of the Einstein Observatory. X-ray surface brightness contours of 47 remnants are shown together with gray-scale pictures. Count rates for these remnants have been derived and are listed for the HRI, IPC, and MPC detectors.

  9. Exact solutions of Einstein and Einstein-Maxwell equations in higher-dimensional spacetime

    International Nuclear Information System (INIS)

    Xu Dianyan; Beijing Univ., BJ

    1988-01-01

    The D-dimensional Schwarzschild-de Sitter metric and Reissner-Nordstrom-de-Sitter metric are derived directly by solving the Einstein and Einstein-Maxwell equations. The D-dimensional Kerr metric is rederived by using the complex coordinate transformation method and the D-dimensional Kerr-de Sitter metric is also given. The conjecture about the D-dimensional metric of a rotating charged mass is given at the end of this paper. (author)

  10. Multilocus analysis of the Exophiala jeanselmei clade containing black yeasts involved in opportunistic disease in humans

    NARCIS (Netherlands)

    Zeng, J.; Feng, P.; Gerrits van den Ende, A.H.G.; Xi, L.; Harrak, M.J.; de Hoog, G.S.

    2014-01-01

    To confirm species delimitations in the ‘jeanselmei-clade’ in the Chaetothyriales, four independent markers were analysed, and phylogenetic trees were reconstructed using different algorithms. Reproductive isolation within the complex and reproductive modes in the species involved were determined,

  11. Piecewise linear manifolds: Einstein metrics and Ricci flows

    International Nuclear Information System (INIS)

    Schrader, Robert

    2016-01-01

    This article provides an attempt to extend concepts from the theory of Riemannian manifolds to piecewise linear (p.l.) spaces. In particular we propose an analogue of the Ricci tensor, which we give the name of an Einstein vector field . On a given set of p.l. spaces we define and discuss (normalized) Einstein flows. p.l. Einstein metrics are defined and examples are provided. Criteria for flows to approach Einstein metrics are formulated. Second variations of the total scalar curvature at a specific Einstein space are calculated. (paper)

  12. How to Cope with the Rare Human Error Events Involved with organizational Factors in Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sa Kil; Luo, Meiling; Lee, Yong Hee [Korea Atomic Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The current human error guidelines (e.g. US DOD handbooks, US NRC Guidelines) are representative tools to prevent human errors. These tools, however, have limits that they do not adapt all operating situations and circumstances such as design base events. In other words, these tools are only adapted foreseeable standardized operating situations and circumstances. In this study, our research team proposed an evidence-based approach such as UK's safety case to coping with the rare human error events such as TMI, Chernobyl, Fukushima accidents. These accidents are representative events involved with rare human errors. Our research team defined the 'rare human errors' as the follow three characterized events; Extremely low frequency Extremely high complicated structure Extremely serious damage of human life and property A safety case is a structured argument, supported by evidence, intended to justify that a system is acceptably safe. The definition by UK defense standard 00-56 issue 4 states that such an evidence-based approach can be contrast with a prescriptive approach to safety certification, which require safety to be justified using a prescribed process. Safety managements and safety regulatory activities based on safety case are effective to control organizational factors in terms of integrated safety management. Especially safety issues relevant with public acceptance are useful to provide practical evidences to the public reasonably. European Union including UK has developed the concept of engineered safety management system to deal with public acceptance using the safety case. In Korea nuclear industry, the Korean Atomic Research Institute has firstly performed a basic research to adapt the safety case in the field of radioactive waste according to the IAEA SSG-23(KAERI/TR-4497, 4531). Excepting the radioactive waste, there is no try to adapt the safety case yet. Most incidents and accidents involved human during operating NPPs have a tendency

  13. How to Cope with the Rare Human Error Events Involved with organizational Factors in Nuclear Power Plants

    International Nuclear Information System (INIS)

    Kim, Sa Kil; Luo, Meiling; Lee, Yong Hee

    2014-01-01

    The current human error guidelines (e.g. US DOD handbooks, US NRC Guidelines) are representative tools to prevent human errors. These tools, however, have limits that they do not adapt all operating situations and circumstances such as design base events. In other words, these tools are only adapted foreseeable standardized operating situations and circumstances. In this study, our research team proposed an evidence-based approach such as UK's safety case to coping with the rare human error events such as TMI, Chernobyl, Fukushima accidents. These accidents are representative events involved with rare human errors. Our research team defined the 'rare human errors' as the follow three characterized events; Extremely low frequency Extremely high complicated structure Extremely serious damage of human life and property A safety case is a structured argument, supported by evidence, intended to justify that a system is acceptably safe. The definition by UK defense standard 00-56 issue 4 states that such an evidence-based approach can be contrast with a prescriptive approach to safety certification, which require safety to be justified using a prescribed process. Safety managements and safety regulatory activities based on safety case are effective to control organizational factors in terms of integrated safety management. Especially safety issues relevant with public acceptance are useful to provide practical evidences to the public reasonably. European Union including UK has developed the concept of engineered safety management system to deal with public acceptance using the safety case. In Korea nuclear industry, the Korean Atomic Research Institute has firstly performed a basic research to adapt the safety case in the field of radioactive waste according to the IAEA SSG-23(KAERI/TR-4497, 4531). Excepting the radioactive waste, there is no try to adapt the safety case yet. Most incidents and accidents involved human during operating NPPs have a tendency

  14. Relevant Etiological Factors Involved in Human Trafficking in order to Practice Prostitution

    Directory of Open Access Journals (Sweden)

    Alexandru Boroi

    2010-06-01

    Full Text Available Human trafficking (especially women and young girls, though men count equally among the victims are recently developed worldwide. The situation in certain regions of Central and Eastern Europe (with the opening of borders, increasing unemployment and poverty, dislocations and reducing state control structures tend to favour the development of all forms of trafficking, especially of human trafficking forsexual exploitation. To adopt appropriate measures to prevent and combat we have to know first the causes and conditions that generate human beings trafficking. Analysis of case studies and police statistics allowed the structuring of categories of causes and conditions that generate and sustain the phenomenon of traffickingin order to practice prostitution.

  15. Paul Ehrenfest, Niels Bohr, and Albert Einstein: Colleagues and Friends

    Science.gov (United States)

    Klein, Martin J.

    2010-09-01

    In May 1918 Paul Ehrenfest received a monograph from Niels Bohr in which Bohr had used Ehrenfest's adiabatic principle as an essential assumption for understanding atomic structure. Ehrenfest responded by inviting Bohr, whom he had never met, to give a talk at a meeting in Leiden in late April 1919, which Bohr accepted; he lived with Ehrenfest, his mathematician wife Tatyana, and their young family for two weeks. Albert Einstein was unable to attend this meeting, but in October 1919 he visited his old friend Ehrenfest and his family in Leiden, where Ehrenfest told him how much he had enjoyed and profited from Bohr's visit. Einstein first met Bohr when Bohr gave a lecture in Berlin at the end of April 1920, and the two immediately proclaimed unbounded admiration for each other as physicists and as human beings. Ehrenfest hoped that he and they would meet at the Third Solvay Conference in Brussels in early April 1921, but his hope was unfulfilled. Einstein, the only physicist from Germany who was invited to it in this bitter postwar atmosphere, decided instead to accompany Chaim Weizmann on a trip to the United States to help raise money for the new Hebrew University in Jerusalem. Bohr became so overworked with the planning and construction of his new Institute for Theoretical Physics in Copenhagen that he could only draft the first part of his Solvay report and ask Ehrenfest to present it, which Ehrenfest agreed to do following the presentation of his own report. After recovering his strength, Bohr invited Ehrenfest to give a lecture in Copenhagen that fall, and Ehrenfest, battling his deep-seated self-doubts, spent three weeks in Copenhagen in December 1921 accompanied by his daughter Tanya and her future husband, the two Ehrenfests staying with the Bohrs in their apartment in Bohr's new Institute for Theoretical Physics. Immediately after leaving Copenhagen, Ehrenfest wrote to Einstein, telling him once again that Bohr was a prodigious physicist, and again

  16. CEACAM3-mediated phagocytosis of human-specific bacterial pathogens involves the adaptor molecule Nck

    OpenAIRE

    Peterson, Lisa

    2010-01-01

    Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are exploited by human-specific pathogens to anchor themselves to or invade host cells. Interestingly, human granulocytes express a specific isoform, CEACAM3, that can direct efficient, opsonin-independent phagocytosis of CEACAM-binding Neisseria, Moraxella and Haemophilus species. As opsonin-independent phagocytosis of CEACAM-binding Neisseria depends on Src-family protein tyrosine kinase (PTK) phosphorylation of the CEACAM3 ...

  17. The AIR's policy on research involving the irradiation of human subjects

    International Nuclear Information System (INIS)

    Smith, A.N.

    1995-01-01

    The policy of the Australian Institute of Radiography with regards to the human subject irradiation is outlined. It is stated that members will not irradiate another individual, nor themselves, solely for the purposes of experimentation or research without gaining the prior approval of an institutional ethics committee. Where possible, researchers should consider the use of patient equivalent or human tissue equivalent phantoms. A short list of references has been compiled to assist members in designing research protocols which comply with the stated policy

  18. Bose-Einstein condensates form in heuristics learned by ciliates deciding to signal 'social' commitments.

    Science.gov (United States)

    Clark, Kevin B

    2010-03-01

    previous work demonstrating ciliates with improving expertise search grouped 'courting' assurances at quantum efficiencies and verify efficient processing by primitive 'social' intelligences involves network forms of Bose-Einstein condensation coupled to preceding thermodynamic-sensitive computational phases. 2009 Elsevier Ireland Ltd. All rights reserved.

  19. Palatini approach to Born-Infeld-Einstein theory and a geometric description of electrodynamics

    International Nuclear Information System (INIS)

    Vollick, Dan N.

    2004-01-01

    The field equations associated with the Born-Infeld-Einstein action are derived using the Palatini variational technique. In this approach the metric and connection are varied independently and the Ricci tensor is generally not symmetric. For sufficiently small curvatures the resulting field equations can be divided into two sets. One set, involving the antisymmetric part of the Ricci tensor R or μν , consists of the field equation for a massive vector field. The other set consists of the Einstein field equations with an energy momentum tensor for the vector field plus additional corrections. In a vacuum with R or μν =0 the field equations are shown to be the usual Einstein vacuum equations. This extends the universality of the vacuum Einstein equations, discussed by Ferraris et al., to the Born-Infeld-Einstein action. In the simplest version of the theory there is a single coupling constant and by requiring that the Einstein field equations hold to a good approximation in neutron stars it is shown that mass of the vector field exceeds the lower bound on the mass of the photon. Thus, in this case the vector field cannot represent the electromagnetic field and would describe a new geometrical field. In a more general version in which the symmetric and antisymmetric parts of the Ricci tensor have different coupling constants it is possible to satisfy all of the observational constraints if the antisymmetric coupling is much larger than the symmetric coupling. In this case the antisymmetric part of the Ricci tensor can describe the electromagnetic field

  20. Einstein-Rosen 'bridge' needs lightlike brane source

    International Nuclear Information System (INIS)

    Guendelman, Eduardo; Kaganovich, Alexander; Nissimov, Emil; Pacheva, Svetlana

    2009-01-01

    The Einstein-Rosen 'bridge' wormhole solution proposed in the classic paper (Einstein and Rosen (1935) ) does not satisfy the vacuum Einstein equations at the wormhole throat. We show that the fully consistent formulation of the original Einstein-Rosen 'bridge' requires solving Einstein equations of bulk D=4 gravity coupled to a lightlike brane with a well-defined world-volume action. The non-vanishing contribution of Einstein-Rosen 'bridge' solution to the right-hand side of Einstein equations at the throat matches precisely the surface stress-energy tensor of the lightlike brane which automatically occupies the throat ('horizon straddling') - a feature triggered by the world-volume lightlike brane dynamics.

  1. Analysis of PRICKLE1 in human cleft palate and mouse development demonstrates rare and common variants involved in human malformations

    Science.gov (United States)

    Yang, Tian; Jia, Zhonglin; Bryant-Pike, Whitney; Chandrasekhar, Anand; Murray, Jeffrey C; Fritzsch, Bernd; Bassuk, Alexander G

    2014-01-01

    Palate development is shaped by multiple molecular signaling pathways, including the Wnt pathway. In mice and humans, mutations in both the canonical and noncanonical arms of the Wnt pathway manifest as cleft palate, one of the most common human birth defects. Like the palate, numerous studies also link different Wnt signaling perturbations to varying degrees of limb malformation; for example, shortened limbs form in mutations of Ror2,Vangl2looptail and, in particular, Wnt5a. We recently showed the noncanonical Wnt/planar cell polarity (PCP) signaling molecule Prickle1 (Prickle like 1) also stunts limb growth in mice. We now expanded these studies to the palate and show that Prickle1 is also required for palate development, like Wnt5a and Ror2. Unlike in the limb, the Vangl2looptail mutation only aggravates palate defects caused by other mutations. We screened Filipino cleft palate patients and found PRICKLE1 variants, both common and rare, at an elevated frequency. Our results reveal that in mice and humans PRICKLE1 directs palate morphogenesis; our results also uncouple Prickle1 function from Vangl2 function. Together, these findings suggest mouse and human palate development is guided by PCP-Prickle1 signaling that is probably not downstream of Vangl2. PMID:24689077

  2. A Student's Guide to Einstein's Major Papers

    International Nuclear Information System (INIS)

    Janssen, Michel

    2013-01-01

    The core of this volume is formed by four chapters (2–5) with detailed reconstructions of the arguments and derivations in four of Einstein's most important papers, the three main papers of his annus mirabilis 1905 (on the light quantum, Brownian motion, and special relativity) and his first systematic exposition of general relativity of 1916. The derivations are given in sufficient detail and in sufficiently modernized notation (without any serious distortion of the originals) for an undergraduate physics major to read and understand them with far less effort than it would take him or her to understand (English translations of) Einstein's original papers. Each of these four papers is accompanied by a detailed introduction, which covers the conceptual development of the relevant field prior to Einstein's contribution to it and corrects some of the myths surrounding these papers that still have not been fully eradicated among physicists. (One quibble: though Kennedy correctly points out that the goal of the light quantum paper was not to explain the photoelectric effect, it is also not quite right to say that 'it was written to explain the Wien region of blackbody radiation' (p. xv). Einstein used this explanatory feat as the central argument for his light quantum hypothesis.) These four chapters then are the most valuable part of the volume. They could be used, independently of one another, but preferably in conjunction with Einstein's original texts, in courses on quantum mechanics, statistical mechanics, electrodynamics, and general relativity, respectively, to add a historical component to such courses. As a historian of science embedded in a physics department who is regularly called upon to give guest lectures in such courses on the history of their subjects, I can highly recommend the volume for this purpose. However, I would not adopt this volume as (one of) the central text(s) for a course on the history of modern physics. For one thing, chapter 1, which

  3. DNA repair in human cells: Methods for the determination of calmodulin involvement

    International Nuclear Information System (INIS)

    Charp, P.A.

    1987-01-01

    Exposure of DNA to either physical or chemical agents can result in the formation of a number of different lesions which must be repaired enzymatically in order for DNA to carry on normal replication and transcription. In most cases, the enzymes involved in this repair of damaged DNA include endonucleases, exonucleases, glycosylases, polymerases, and ligases. Each group of enzymes is involved in precise steps in DNA repair. Exposure to physical agents such as ultraviolet light (UV) at a wavelength of 254 nm is repaired by two distinct and different mechanisms. One mode of enzymatic repair of pyrimidine dimers is accomplished in situ by photoreactivation of UV-induced pyrimidine dimers by photoreactivating light. The second mode of enzymatic repair is the excision repair of pyrimidine dimers involving several different enzymes including endonuclease, exonuclease, and DNA ligase. A summary of the sequence of enzymatic steps involved is shown. It has been observed that specific drugs which bind to and alter the action of calmodulin in cells block DNA synthesis. This suggests that calmodulin may play a role both in normal DNA replication and repair. Others using an indirect method measuring the degree of DNA nucleoid sedimentation, showed that the specific anti-calmodulin agent W-13 slowed the rate of DNA repair. Others showed that DNA synthesis in T51B rat liver cells could be blocked with the addition of either chlorpromazine or trifluoperazine

  4. Involvement of the corticospinal tract in the control of human gait

    DEFF Research Database (Denmark)

    Barthélemy, Dorothy; Grey, Michael James; Nielsen, Jens Bo

    2011-01-01

    to rehabilitation therapy, which will enhance gait ability and recovery in patients with lesions to the central nervous system (CNS). We review evidence for the involvement of the primary motor cortex and the CST during normal and perturbed walking and during gait adaptation. We will also discuss knowledge...

  5. Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors

    NARCIS (Netherlands)

    Verhaagh, S.; Jong, E. de; Goudsmit, J.; Lecollinet, S.; Gillissen, G.; Vries, M. de; Leuven, K. van; Que, I.; Ouwehand, K.; Mintardjo, R.; Weverling, G.J.; Radošević, K.; Richardson, J.; Eloit, M.; Lowik, C.; Quax, P.; Havenga, M.

    2006-01-01

    Wild-type strains of mice do not express CD46, a high-affinity receptor for human group B adenoviruses including type 35. Therefore, studies performed to date in mice using replication-incompetent Ad35 (rAd35) vaccine carriers may underestimate potency or result in altered vector distribution. Here,

  6. Involvement of Connective Tissue Growth Factor in Human and Experimental Hypertensive Nephrosclerosis

    NARCIS (Netherlands)

    Ito, Yasuhiko; Aten, Jan; Nguyen, Tri Q.; Joles, Jaap A.; Matsuo, Seiichi; Weening, Jan J.; Goldschmeding, Roel

    2011-01-01

    Background/Aims: Connective tissue growth factor (CTGF; CCN2) has been implicated as a marker and mediator of fibrosis in human and experimental renal disease. Methods: We performed a comparative analysis of CTGF expression in hypertensive patients with and without nephrosclerosis, and in

  7. The Public Health Service guidelines. Governing research involving human subjects: An analysis of the policy-making process

    Science.gov (United States)

    Frankel, M. S.

    1972-01-01

    The policy making process which led to development of the Public Health Service Guidelines governing research involving human subjects is outlined. Part 1 examines the evolution of PHS Guidelines, tracing (1) evolution of thought and legal interpretation regarding research using human subjects; (2) initial involvement of the Federal government; (3) development of the government's research program; (4) the social-political environment in which formal government policy was developed; and (5) various policy statements issued by the government. Part 2 analyzes the process by which PHS Guidelines were developed and examines the values and other underlying factors which contributed to their development. It was concluded that the evolution of the Guidelines is best understood within the context of a mixed-scanning strategy. In such a strategy, policy makers make fundamental decisions regarding the basic direction of policy and subsequent decisions are made incrementally and within the contexts set by the original fundamental decisions.

  8. Genes Involved in Human Ribosome Biogenesis areTranscriptionally Upregulated in Colorectal Cancer

    DEFF Research Database (Denmark)

    Mansilla, Francisco; Lamy, Philippe; Ørntoft, Torben Falck

    2009-01-01

    Microarray gene expression profiling comprising 168 colorectal adenocarcinomas and 10 normal mucosas showed that over 79% of the genes involved in human ribosome biogenesis are significantly upregulated (log2>0.5, p<10-3) when compared to normal mucosa. Overexpression was independent of microsate......Microarray gene expression profiling comprising 168 colorectal adenocarcinomas and 10 normal mucosas showed that over 79% of the genes involved in human ribosome biogenesis are significantly upregulated (log2>0.5, p... of microsatellite status. The promoters of the genes studied showed a significant enrichment for several transcription factor binding sites. There was a significant correlation between the number of binding site targets for these transcription factors and the observed gene transcript upregulation. The upregulation...

  9. Involvement of Human Estrogen Related Receptor Alpha 1 (hERR 1) in Breast Cancer and Hormonally Insensitive Disease

    Science.gov (United States)

    2000-08-01

    SV40 early-to-late switch involves titration of cellular transcriptional repressors, Genes Dev. 7: 2206-19, 1993. 6. Bonnelye, E., Vanacker , J. M ...transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene, Mol Cell Biol. 17: 5400-9, 1997. 8. Vanacker , J. M ., Bonnelye, E...related receptor-alpha), Mol Endocrinol. 13: 764-73, 1999. 9. Vanacker , J. M ., Pettersson, K., Gustafsson, J. A., and Laudet, V. Transcriptional

  10. Einstein's strugges with quantum theory a reappraisal

    CERN Document Server

    Home, Dipankar

    2007-01-01

    Einstein’s Struggles with Quantum Theory: A Reappraisal by Dipankar Home and Andrew Whitaker provides a detailed account of Albert Einstein’s thinking in regard to quantum physics. Until recently, most of Einstein’s views on quantum physics were dismissed and even ridiculed; some critics even suggested that Einstein was not able to grasp the complexities of the formalism of quantum theory and subtleties of the standard interpretation of this theory known as the Copenhagen interpretation put forward by Niels Bohr and his colleagues. But was that true? Modern scholarship argues otherwise, insist Drs. Home and Whitaker, who painstakingly explain the questions Einstein raised as well as offer a detailed discussion of Einstein’s position and major contributions to quantum theory, connecting them with contemporary studies on fundamental aspects of this theory. This unique book presents a mathematical as well as a non-mathematical route through the theories, controversies, and investigations, making the disc...

  11. It's about time understanding Einstein's relativity

    CERN Document Server

    Mermin, N David

    2005-01-01

    In It's About Time, N. David Mermin asserts that relativity ought to be an important part of everyone's education--after all, it is largely about time, a subject with which all are familiar. The book reveals that some of our most intuitive notions about time are shockingly wrong, and that the real nature of time discovered by Einstein can be rigorously explained without advanced mathematics. This readable exposition of the nature of time as addressed in Einstein's theory of relativity is accessible to anyone who remembers a little high school algebra and elementary plane geometry. The book evolved as Mermin taught the subject to diverse groups of undergraduates at Cornell University, none of them science majors, over three and a half decades. Mermin's approach is imaginative, yet accurate and complete. Clear, lively, and informal, the book will appeal to intellectually curious readers of all kinds, including even professional physicists, who will be intrigued by its highly original approach.

  12. Bose-Einstein condensation of atomic gases

    International Nuclear Information System (INIS)

    Anglin, J. R.; Ketterle, W.

    2003-01-01

    The early experiments on Bose-Einstein condensation in dilute atomic gases accomplished three longstanding goals. First, cooling of neutral atoms into their motional state, thus subjecting them to ultimate control, limited only by Heisenberg uncertainty relation. Second, creation of a coherent sample of atoms, in which all occupy the same quantum states, and the realization of atom lasers - devices that output coherent matter waves. And third, creation of gaseous quantum fluid, with properties that are different from the quantum liquids helium-3 and helium-4. The field of Bose-Einstein condensation of atomic gases has continued to progress rapidly, driven by the combination of new experimental techniques and theoretical advances. The family of quantum degenerate gases has grown, and now includes metastable and fermionic atoms. condensates have become an ultralow-temperature laboratory for atom optics, collisional physics and many-body physics, encompassing phonons, superfluidity, quantized vortices, Josephson junctions and quantum phase transitions. (author)

  13. Einstein metrics and Brans-Dicke superfields

    International Nuclear Information System (INIS)

    Marques, S.

    1988-01-01

    It is obtained here a space conformal to the Einstein space-time, making the transition from an internal bosonic space, constructed with the Majorana constant spinors in the Majorana representation, to a bosonic ''superspace,'' through the use of Einstein vierbeins. These spaces are related to a Grassmann space constructed with the Majorana spinors referred to above, where the ''metric'' is a function of internal bosonic coordinates. The conformal function is a scale factor in the zone of gravitational radiation. A conformal function dependent on space-time coordinates can be constructed in that region when we introduce Majorana spinors which are functions of those coordinates. With this we obtain a scalar field of Brans-Dicke type. 11 refs

  14. Generalization of Einstein's gravitational field equations

    Science.gov (United States)

    Moulin, Frédéric

    2017-12-01

    The Riemann tensor is the cornerstone of general relativity, but as is well known it does not appear explicitly in Einstein's equation of gravitation. This suggests that the latter may not be the most general equation. We propose here for the first time, following a rigorous mathematical treatment based on the variational principle, that there exists a generalized 4-index gravitational field equation containing the Riemann curvature tensor linearly, and thus the Weyl tensor as well. We show that this equation, written in n dimensions, contains the energy-momentum tensor for matter and that of the gravitational field itself. This new 4-index equation remains completely within the framework of general relativity and emerges as a natural generalization of the familiar 2-index Einstein equation. Due to the presence of the Weyl tensor, we show that this equation contains much more information, which fully justifies the use of a fourth-order theory.

  15. Ritz, Einstein, and the Emission Hypothesis

    Science.gov (United States)

    Martínez, Alberto A.

    . Just as Albert Einstein's special theory of relativity was gaining acceptance around 1908, the young Swiss physicist Walter Ritz advanced a competing though preliminary emission theory that sought to explain the phenomena of electrodynamics on the assumption that the speed of light depends on the motion of its source. I survey Ritz's unfinished work in this area and review the reasons why Einstein and other physicists rejected Ritz's and other emission theories. Since Ritz's emission theory attracted renewed attention in the 1960s, I discuss how the earlier observational evidence was misconstrued as telling against it more conclusively than actually was the case. Finally, I contrast the role played by evidence against Ritz's theory with other factors that led to the early rejection of his approach.

  16. Scattering amplitudes in N=2 Maxwell-Einstein and Yang-Mills/Einstein supergravity

    CERN Document Server

    Chiodaroli, Marco; Johansson, Henrik; Roiban, Radu

    2015-01-01

    We expose a double-copy structure in the scattering amplitudes of the generic Jordan family of N=2 Maxwell-Einstein and Yang-Mills/Einstein supergravity theories in four and five dimensions. The Maxwell-Einstein supergravity amplitudes are obtained through the color/kinematics duality as a product of two gauge-theory factors; one originating from pure N=2 super-Yang-Mills theory and the other from the dimensional reduction of a bosonic higher-dimensional pure Yang-Mills theory. We identify a specific symplectic frame in four dimensions for which the on-shell fields and amplitudes from the double-copy construction can be identified with the ones obtained from the supergravity Lagrangian and Feynman-rule computations. The Yang-Mills/Einstein supergravity theories are obtained by gauging a compact subgroup of the isometry group of their Maxwell-Einstein counterparts. For the generic Jordan family this process is identified with the introduction of cubic scalar couplings on the bosonic gauge-theory side, which th...

  17. Scattering amplitudes in N=2 Maxwell-Einstein and Yang-Mills/Einstein supergravity

    International Nuclear Information System (INIS)

    Chiodaroli, Marco; Günaydin, Murat; Johansson, Henrik; Roiban, Radu

    2015-01-01

    We expose a double-copy structure in the scattering amplitudes of the generic Jordan family of N=2 Maxwell-Einstein and Yang-Mills/Einstein supergravity theories in four and five dimensions. The Maxwell-Einstein supergravity amplitudes are obtained through the color/kinematics duality as a product of two gauge-theory factors; one originating from pure N=2 super-Yang-Mills theory and the other from the dimensional reduction of a bosonic higher-dimensional pure Yang-Mills theory. We identify a specific symplectic frame in four dimensions for which the on-shell fields and amplitudes from the double-copy construction can be identified with the ones obtained from the supergravity Lagrangian and Feynman-rule computations. The Yang-Mills/Einstein supergravity theories are obtained by gauging a compact subgroup of the isometry group of their Maxwell-Einstein counterparts. For the generic Jordan family this process is identified with the introduction of cubic scalar couplings on the bosonic gauge-theory side, which through the double copy are responsible for the non-abelian vector interactions in the supergravity theory. As a demonstration of the power of this structure, we present explicit computations at tree-level and one loop. The double-copy construction allows us to obtain compact expressions for the supergravity superamplitudes, which are naturally organized as polynomials in the gauge coupling constant.

  18. Involvement of hGLD-2 in cytoplasmic polyadenylation of human p53 mRNA

    DEFF Research Database (Denmark)

    Glahder, Jacob-Andreas Harald; Norrild, Bodil

    2011-01-01

    Cytoplasmic polyadenylation is a post-transcriptional mechanism regulating mRNA stability and translation. The human p53 3'-untranslated region (3'-UTR) contains two regions similar to cytoplasmic polyadenylation elements (CPEs) just upstream of the poly(A) hexanucleotide. Evaluation of the p53 CPE......-like elements was performed by luciferase reporter assays, qPCR, and poly(A) assays. Herein, we report the down regulation of a luciferase reporter fused to the p53 3'-UTR, when human CPE-binding protein 1 (hCPEB1) is overexpressed. This inhibition is partially rescued when hCPEB1fused to hGLD-2 [a human...... cytoplasmic poly(A) polymerase] is overexpressed instead. The stability of a luciferase mRNA containing the p53 3'-UTR downstream, is decreased when hCPEB1 is overexpressed as seen by qPCR. Expression of hGLD-2 restores the mRNA stability. This is due to elongation of the poly(A) tail as seen by a PCR...

  19. Einstein gravity emerging from quantum weyl gravity

    International Nuclear Information System (INIS)

    Zee, A.

    1983-01-01

    We advocate a conformal invariant world described by the sum of the Weyl, Dirac, and Yang-Mills action. Quantum fluctuations bring back Einstein gravity so that the long-distance phenomenology is as observed. Formulas for the induced Newton's constant and Eddington's constant are derived in quantized Weyl gravity. We show that the analogue of the trace anomaly for the Weyl action is structurally similar to that for the Yang-Mills action

  20. Genuine Multipartite Einstein-Podolsky-Rosen Steering

    Science.gov (United States)

    He, Q. Y.; Reid, M. D.

    2013-12-01

    We develop the concept of genuine N-partite Einstein-Podolsky-Rosen (EPR) steering. This nonlocality is the natural multipartite extension of the original EPR paradox. Useful properties emerge that are not guaranteed for genuine multipartite entangled states. In particular, there is a close link with the task of one-sided, device-independent quantum secret sharing. We derive inequalities to demonstrate multipartite EPR steering for Greenberger-Horne-Zeilinger and Gaussian continuous variable states in loophole-free scenarios.

  1. Time symmetry and the Einstein paradox

    International Nuclear Information System (INIS)

    Costa de Beauregard, O.

    1977-01-01

    The characteristic difference between the paleoquantal calculation (addition of partial probabilities) and the neoquantal one (addition of partial amplitudes) for the correlation of photon polarizations in cascade transitions is derived in terms of elementary trigonometry. This deliberate use of simple formulae aims at a transparent rendering of the change in paradigm required by the so-called EPR paradox (which is truly the 1927 Einstein paradox), namely that 1) the two photons do not possess polarizations of their own when leaving the source C, but borrow one later, when interacting with the analysers L and N; 2) the die is thus not cast at C, but later, at L and N; 3) the correlation between the measurements at L and N is tied through C, in their common past. The tight connection between this ''Einstein nonseparability'' and the nonlocality in Feynman's ''theory of positrons'' is demonstrated through an analysis of the e + e - annihilation into two photons. Thus the Einstein paradox corresponds, in the ''new wavelike probability calculus'', to the Loschmid and Zermelo sort of paradox in the old probability calculus. That is, it contrasts the intrinsic time symmetry existing at the elementary level to the factlike macroscopic time asymmetry. The discussion deliberately by-passes the hidden-variable problem, the model in this being Einstein's by-passing of the mechanical aether when proposing special relativity. It is believed today, like in 1905, the problem is tayloring the wording after the (operationally good) mathematics. Moreover, that the change in paradigm, which is needed, comes through a victory of formalism over modelism. (author)

  2. Bose-Einstein correlation in Landau's model

    International Nuclear Information System (INIS)

    Hama, Y.; Padula, S.S.

    1986-01-01

    Bose-Einstein correlation is studied by taking an expanding fluid given by Landau's model as the source, where each space-time point is considered as an independent and chaotic emitting center with Planck's spectral distribution. As expected, the correlation depends on the relative angular positions as well as on the overall localization of the measuring system and it turns out that the average dimension of the source increases with the multiplicity N/sub ch/

  3. Bose-Einstein condensation of paraxial light

    OpenAIRE

    Klaers, J.; Schmitt, J.; Damm, T.; Vewinger, F.; Weitz, M.

    2011-01-01

    Photons, due to the virtually vanishing photon-photon interaction, constitute to very good approximation an ideal Bose gas, but owing to the vanishing chemical potential a (free) photon gas does not show Bose-Einstein condensation. However, this is not necessarily true for a lower-dimensional photon gas. By means of a fluorescence induced thermalization process in an optical microcavity one can achieve a thermal photon gas with freely adjustable chemical potential. Experimentally, we have obs...

  4. Cosmic censorship in quantum Einstein gravity

    Science.gov (United States)

    Bonanno, A.; Koch, B.; Platania, A.

    2017-05-01

    We study the quantum gravity modification of the Kuroda-Papapetrou model induced by the running of the Newton’s constant at high energy in quantum Einstein gravity. We argue that although the antiscreening character of the gravitational interaction favours the formation of a naked singularity, quantum gravity effects turn the classical singularity into a ‘whimper’ singularity which remains naked for a finite amount of advanced time.

  5. Sasaki-Einstein Manifolds and Volume Minimisation

    CERN Document Server

    Martelli, D; Yau, S T; Martelli, Dario; Sparks, James; Yau, Shing-Tung

    2006-01-01

    We study a variational problem whose critical point determines the Reeb vector field for a Sasaki-Einstein manifold. This extends our previous work on Sasakian geometry by lifting the condition that the manifolds are toric. We show that the Einstein-Hilbert action, restricted to a space of Sasakian metrics on a link L in a Calabi-Yau cone M, is the volume functional, which in fact is a function on the space of Reeb vector fields. We relate this function both to the Duistermaat-Heckman formula and also to a limit of a certain equivariant index on M that counts holomorphic functions. Both formulae may be evaluated by localisation. This leads to a general formula for the volume function in terms of topological fixed point data. As a result we prove that the volume of any Sasaki-Einstein manifold, relative to that of the round sphere, is always an algebraic number. In complex dimension n=3 these results provide, via AdS/CFT, the geometric counterpart of a-maximisation in four dimensional superconformal field theo...

  6. Finding Horndeski theories with Einstein gravity limits

    Energy Technology Data Exchange (ETDEWEB)

    McManus, Ryan; Lombriser, Lucas; Peñarrubia, Jorge, E-mail: ryanm@roe.ac.uk, E-mail: llo@roe.ac.uk, E-mail: jorpega@roe.ac.uk [Institute for Astronomy, University of Edinburgh, Royal Observatory, Blackford Hill, Edinburgh, EH9 3HJ (United Kingdom)

    2016-11-01

    The Horndeski action is the most general scalar-tensor theory with at most second-order derivatives in the equations of motion, thus evading Ostrogradsky instabilities and making it of interest when modifying gravity at large scales. To pass local tests of gravity, these modifications predominantly rely on nonlinear screening mechanisms that recover Einstein's Theory of General Relativity in regions of high density. We derive a set of conditions on the four free functions of the Horndeski action that examine whether a specific model embedded in the action possesses an Einstein gravity limit or not. For this purpose, we develop a new and surprisingly simple scaling method that identifies dominant terms in the equations of motion by considering formal limits of the couplings that enter through the new terms in the modified action. This enables us to find regimes where nonlinear terms dominate and Einstein's field equations are recovered to leading order. Together with an efficient approximation of the scalar field profile, one can then further evaluate whether these limits can be attributed to a genuine screening effect. For illustration, we apply the analysis to both a cubic galileon and a chameleon model as well as to Brans-Dicke theory. Finally, we emphasise that the scaling method also provides a natural approach for performing post-Newtonian expansions in screened regimes.

  7. Einstein and the history of general relativity

    International Nuclear Information System (INIS)

    Howard, D.; Stachel, J.

    1989-01-01

    This book is a collection of essays by the authors and other people that deal with scientific opinions that led Einstein and his contemporaries to their views of general relativity. Some of the essays explore Einstein's passage from the special theory through a sequence of gravitational theories to the discovery of the field equations of the grand theory in November 1915. Two other essays discuss Einstein's public and private exchanges with Max Abraham and Tullio Levi-Civita in 1913 and 1914. A sympathetic picture of H.A. Lorentz's reaction to the general theory of relativity is included, and a careful and insightful essay on the early understanding of the Schwarzschild-Droste solution to the field equations of general relativity is presented. One paper presents a discussion on the state of the enterprise of general relativity between 1925 and 1928, and a short essay details the history of steps toward quantum gravitational through canonical quantization. A discussion of the history of derivations of the geodesic equation of motion from the field equation and conservation laws of the general theory is presented. The early history of geometrical unified field theories is included

  8. Einstein's Gravity and Dark Energy/Matter

    CERN Document Server

    Sarfatti, J

    2003-01-01

    Should Einstein's general relativity be quantized in the usual way even though it is not renormalizable the way the spin 1/2 lepto-quark - spin 1 gauge force boson local field theories are? Condensed matter theorists using P.W. Anderson's "More is different" approach, consistent with Andrei Sakharov's idea of "metric elasticity" with gravity emergent out of quantum electrodynamic zero point vacuum fluctuations, is the approach I take in this paper. The QED vacuum in globally-flat Minkowski space-time is unstable due to exchange of virtual photons between virtual electrons and positron "holes" near the -mc2 Fermi surface well inside the 2mc2 energy gap. This results in a non-perturbative emergence of both Einstein's gravity and a unified dark energy/dark matter w = -1 exotic vacuum zero point fluctuation field controlled by the local macro-quantum vacuum coherent field. The latter is a Bose-Einstein condensate of virtual off-mass-shell bound electron-positron pairs. The dark matter exotic vacuum phase with pos...

  9. Bose-Einstein condensation of paraxial light

    Science.gov (United States)

    Klaers, J.; Schmitt, J.; Damm, T.; Vewinger, F.; Weitz, M.

    2011-10-01

    Photons, due to the virtually vanishing photon-photon interaction, constitute to very good approximation an ideal Bose gas, but owing to the vanishing chemical potential a (free) photon gas does not show Bose-Einstein condensation. However, this is not necessarily true for a lower-dimensional photon gas. By means of a fluorescence induced thermalization process in an optical microcavity one can achieve a thermal photon gas with freely adjustable chemical potential. Experimentally, we have observed thermalization and subsequently Bose-Einstein condensation of the photon gas at room temperature. In this paper, we give a detailed description of the experiment, which is based on a dye-filled optical microcavity, acting as a white-wall box for photons. Thermalization is achieved in a photon number-conserving way by photon scattering off the dye molecules, and the cavity mirrors both provide an effective photon mass and a confining potential-key prerequisites for the Bose-Einstein condensation of photons. The experimental results are in good agreement with both a statistical and a simple rate equation model, describing the properties of the thermalized photon gas.

  10. Measuring spirituality as a universal human experience: development of the Spiritual Attitude and Involvement List (SAIL).

    Science.gov (United States)

    de Jager Meezenbroek, Eltica; Garssen, Bert; Van den Berg, Machteld; Tuytel, Gerwi; Van Dierendonck, Dirk; Visser, Adriaan; Schaufeli, Wilmar B

    2012-01-01

    Many cancer patients experience spirituality as highly supportive while coping with their disease. Most research as well as most questionnaires in this field is religious orientated. The Spiritual Attitude and Involvement List was developed to enable research on spirituality among religious and nonreligious people. It consists of seven subscales that measure connectedness with oneself, with others and nature, and with the transcendent. Among a student, a healthy population, a healthy interested, a curative cancer, and a palliative cancer sample factorial, convergent and discriminant validity were demonstrated, as well as adequate internal consistency and test-retest reliability.

  11. Holographic renormalization of Einstein-Maxwell-Dilaton theories

    International Nuclear Information System (INIS)

    Kim, Bom Soo

    2016-01-01

    We generalize the boundary value problem with a mixed boundary condition that involves the gauge and scalar fields in the context of Einstein-Maxwell-Dilaton theories. In particular, the expectation value of the dual scalar operator can be a function of the expectation value of the current operator. The properties are prevalent in a fixed charge ensemble because the conserved charge is shared by both fields through the dilaton coupling, which is also responsible for non-Fermi liquid properties. We study the on-shell action and the stress energy tensor to note practical importances of the boundary value problem. In the presence of the scalar fields, physical quantities are not fully fixed due to the finite boundary terms that manifest in the massless scalar or the scalar with mass saturating the Breitenlohner-Freedman bound.

  12. Proteins involved in invasion of human red blood cells by malaria parasites

    Directory of Open Access Journals (Sweden)

    Ewa Jaśkiewicz

    2010-11-01

    Full Text Available Malaria is a disease caused by parasites of Plasmodium species. It is responsible for around 1-2 million deaths annually, mainly children under the age of 5. It occurs mainly in tropical and subtropical areas.Malaria is caused by five Plasmodium species:[i] P. falciparum, P. malariae, P. vivax, P. knowlesi[/i] and [i]P. ovale[/i]. Mosquitoes spread the disease by biting humans. The malaria parasite has two stages of development: the human stage and the mosquito stage. The first stage occurs in the human body and is divided into two phases: the liver phase and the blood phase.The invasion of erythrocytes by [i]Plasmodium[/i] merozoites is a multistep process of specific protein interactions between the parasite and red blood cell. The first step is the reversible merozoite attachment to the erythrocyte followed by its apical reorientation, then formation of an irreversible “tight” junction and finally entry into the red cell in a parasitophorous vacuole.The blood phase is supported by a number of proteins produced by the parasite. The merozoite surface GPI-anchored proteins (MSP-1, 2, 4, 5, 8 and 10 assist in the process of recognition of susceptible erythrocytes, apical membrane antigen (AMA-1 may be directly responsible for apical reorientation of the merozoite and apical proteins which function in tight junction formation. These ligands are members of two families: Duffy binding-like (DBL and reticulocyte binding-like (RBL proteins. In [i]Plasmodium[/i] [i]falciparum[/i] the DBL family includes: EBA-175, EBA-140 (BAEBL, EBA-181 (JESEBL, EBA-165 (PEBL and EBL-1 ligands.To date, no effective antimalarial vaccine has been developed, but there are several studies for this purpose. Therefore, it is crucial to understand the molecular basis of host cells invasion by parasites. Major efforts are focused on developing a multiantigenic and multiepitope vaccine preventing all steps of [i]Plasmodium[/i] invasion.

  13. The involvement of human RECQL4 in DNA double-strand break repair

    DEFF Research Database (Denmark)

    Singh, Dharmendra Kumar; Karmakar, Parimal; Aamann, Maria Diget

    2010-01-01

    Rothmund-Thomson syndrome (RTS) is an autosomal recessive hereditary disorder associated with mutation in RECQL4 gene, a member of the human RecQ helicases. The disease is characterized by genomic instability, skeletal abnormalities and predisposition to malignant tumors, especially osteosarcomas......-induced DSBs and remains for a shorter duration than WRN and BLM, indicating its distinct role in repair of DSBs. Endogenous RECQL4 also colocalizes with gammaH2AX at the site of DSBs. The RECQL4 domain responsible for its DNA damage localization has been mapped to the unique N-terminus domain between amino...

  14. Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings

    Directory of Open Access Journals (Sweden)

    Thomas F Münte

    2008-03-01

    Full Text Available The Nucleus accumbens (Nacc has been proposed to act as a limbic-motor interface. Here, using invasive intraoperative recordings in an awake patient suffering from obsessive-compulsive disease (OCD, we demonstrate that its activity is modulated by the quality of performance of the subject in a choice reaction time task designed to tap action monitoring processes. Action monitoring, that is, error detection and correction, is thought to be supported by a system involving the dopaminergic midbrain, the basal ganglia, and the medial prefrontal cortex. In surface electrophysiological recordings, action monitoring is indexed by an error-related negativity (ERN appearing time-locked to the erroneous responses and emanating from the medial frontal cortex. In preoperative scalp recordings the patient's ERN was found to be signifi cantly increased compared to a large (n= 83 normal sample, suggesting enhanced action monitoring processes. Intraoperatively, error-related modulations were obtained from the Nacc but not from a site 5 mm above. Importantly, crosscorrelation analysis showed that error-related activity in the Nacc preceded surface activity by 40 ms. We propose that the Nacc is involved in action monitoring, possibly by using error signals from the dopaminergic midbrain to adjust the relative impact of limbic and prefrontal inputs on frontal control systems in order to optimize goal-directed behavior.

  15. What Einstein did not know

    International Nuclear Information System (INIS)

    Perl, M.L.

    2008-01-01

    This public lecture is about 100 years of research on elementary particles and fundamental forces, beginning with the identification of the electron about 1900 and extending to the astonishing discovery of Dark Matter in the late 1900s. I talk about the elementary particle concept; the discoveries of leptons, quarks and force carrying particles; and some of the experimental technology used. I tell of my own research, our discovery of the tau lepton, our long, inconclusive search for fractional charged particles, and my new involvement in astronomical research on Dark Matter. I conclude by looking ahead to old unsolved puzzles and new questions on the fundamental nature of matter and force that face us in the 21st Century. (author)

  16. What Einstein Did Not Know

    International Nuclear Information System (INIS)

    Perl, M

    2007-01-01

    This public lecture is about 100 years of research on elementary particles and fundamental forces, beginning with the identification of the electron about 1900 and extending to the astonishing discovery of Dark Matter in the late 1900s. The author talks about the elementary particle concept; the discoveries of leptons, quarks and force carrying particles; and some of the experimental technology used. The author tells of his own research, the discovery of the tau lepton, the long, inconclusive search for fractional charged particles and his new involvement in astronomical research on Dark Matter. He concludes by looking ahead to old unsolved puzzles and new questions on the fundamental nature of matter and force that face us in the 21st Century

  17. TIME AND ETERNITY FROM PLOTINUS AND BOETHIUS TO EINSTEIN

    Directory of Open Access Journals (Sweden)

    Chase, Michael

    2014-01-01

    Full Text Available This article seeks to show that the views on time and eternity of Plotinus and Boethius are analogous to those implied by the block-time perspective in contemporary philosophy of time, as implied by the mathematical physics of Einstein and Minkowski. Both Einstein and Boethius utilized their theories of time and eternity with the practical goal of providing consolation to persons in distress; this practice of consolatio is compared to Pierre Hadot’s studies of the “Look from Above”, of the importance of concentrating on the present moment, and his emphasis on ancient philosophy as providing therapy for the soul, instead of mere abstract speculation for its own sake. In the first part of the article, Einstein’s views are compared with those of Plotinus, and with the elucidation of Plotinus’ views provided in the Arabic Theology of Aristotle. The second part of the article studies Boethius’ Consolation of Philosophy, which, contrary to recent interpretations, is indeed a genuine consolation rather than a parody thereof. The Consolation shows how the study of the Neoplatonic philosophical curriculum can lead the student along the path to salvation, by awakening and elaborating his innate ideas. To illustrate this doctrine, a passage from the little-known Pseudo-Boethian treatise De diis et praesensionibus is studied. Finally, after a survey of Boethius’ view on fate and providence, and Aristotle’s theory of future contingents, I study Boethius’ three main arguments in favor of the reconcilability of divine omniscience and human free will: the distinction between absolute and conditional necessity, the principle that the nature of knowledge is determined by the knower, and finally the doctrine that God lives in an eternal present, seeing past, present, and future simultaneously. This last view, developed primarily from Plotinus, is once again argued to be analogous to that advocated by contemporary block-time theorists on the basis

  18. On solutions of Einstein and Einstein-Yang-Mills equations with (maximal) conformal subsymmetries

    International Nuclear Information System (INIS)

    Sinzinkayo, S.; Demaret, J.

    1985-01-01

    The maximal subgroups of the conformal group (which have in common as a subgroup the group of pure spatial rotations) are considered as isometry groups of conformally flat space-times. The corresponding cosmological solutions of Einstein's field equations are identified. For each of them, the possibility is investigated that it could be generated by an SU(2) Yang-Mills field built, via the Corrigan-Fairlie-'t Hooft-Wilczek ansatz, from a scalar field identical with the square root of the conformal factor defining the space-time metric tensor. In particular, the Einstein cosmological model can be generated in this manner, but in the framework of strong gravity only, a micro-Einstein universe being then viewed as a possible model for a hadron. (author)

  19. Human Blue Cone Opsin Regeneration Involves Secondary Retinal Binding with Analog Specificity.

    Science.gov (United States)

    Srinivasan, Sundaramoorthy; Fernández-Sampedro, Miguel A; Morillo, Margarita; Ramon, Eva; Jiménez-Rosés, Mireia; Cordomí, Arnau; Garriga, Pere

    2018-03-27

    Human color vision is mediated by the red, green, and blue cone visual pigments. Cone opsins are G-protein-coupled receptors consisting of an opsin apoprotein covalently linked to the 11-cis-retinal chromophore. All visual pigments share a common evolutionary origin, and red and green cone opsins exhibit a higher homology, whereas blue cone opsin shows more resemblance to the dim light receptor rhodopsin. Here we show that chromophore regeneration in photoactivated blue cone opsin exhibits intermediate transient conformations and a secondary retinoid binding event with slower binding kinetics. We also detected a fine-tuning of the conformational change in the photoactivated blue cone opsin binding site that alters the retinal isomer binding specificity. Furthermore, the molecular models of active and inactive blue cone opsins show specific molecular interactions in the retinal binding site that are not present in other opsins. These findings highlight the differential conformational versatility of human cone opsin pigments in the chromophore regeneration process, particularly compared to rhodopsin, and point to relevant functional, unexpected roles other than spectral tuning for the cone visual pigments. Copyright © 2018 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  20. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.

    Science.gov (United States)

    Levy, Daniel; Neuhausen, Susan L; Hunt, Steven C; Kimura, Masayuki; Hwang, Shih-Jen; Chen, Wei; Bis, Joshua C; Fitzpatrick, Annette L; Smith, Erin; Johnson, Andrew D; Gardner, Jeffrey P; Srinivasan, Sathanur R; Schork, Nicholas; Rotter, Jerome I; Herbig, Utz; Psaty, Bruce M; Sastrasinh, Malinee; Murray, Sarah S; Vasan, Ramachandran S; Province, Michael A; Glazer, Nicole L; Lu, Xiaobin; Cao, Xiaojian; Kronmal, Richard; Mangino, Massimo; Soranzo, Nicole; Spector, Tim D; Berenson, Gerald S; Aviv, Abraham

    2010-05-18

    Telomeres are engaged in a host of cellular functions, and their length is regulated by multiple genes. Telomere shortening, in the course of somatic cell replication, ultimately leads to replicative senescence. In humans, rare mutations in genes that regulate telomere length have been identified in monogenic diseases such as dyskeratosis congenita and idiopathic pulmonary fibrosis, which are associated with shortened leukocyte telomere length (LTL) and increased risk for aplastic anemia. Shortened LTL is observed in a host of aging-related complex genetic diseases and is associated with diminished survival in the elderly. We report results of a genome-wide association study of LTL in a consortium of four observational studies (n = 3,417 participants with LTL and genome-wide genotyping). SNPs in the regions of the oligonucleotide/oligosaccharide-binding folds containing one gene (OBFC1; rs4387287; P = 3.9 x 10(-9)) and chemokine (C-X-C motif) receptor 4 gene (CXCR4; rs4452212; P = 2.9 x 10(-8)) were associated with LTL at a genome-wide significance level (P a gene associated with LTL (P = 1.1 x 10(-5)). The identification of OBFC1 through genome-wide association as a locus for interindividual variation in LTL in the general population advances the understanding of telomere biology in humans and may provide insights into aging-related disorders linked to altered LTL dynamics.

  1. The role of the teacher degree and his involvement with the digital humanities

    Directory of Open Access Journals (Sweden)

    Daniel Rodrigo-Cano

    2018-05-01

    Full Text Available The technological convergence is leading to rapid change in the communicative context and, above all, education. In this sense, the present investigation tries to analyze a twofold: on the one hand, identify the skills of university professors to the digital humanities for social learning and, on the other hand, recognize the good university practices, to identify the most widely used tools, as well as the motivations that lead to success in the collaborative methodologies in Web 2.0. Following this, the research is focused through a qualitative-quantitative methodology with the collection of 537 questionnaires made up of students and the development of a focus groups with a total of 20 teachers belonging to the University of Cadiz, Seville and Huelva. In this sense, it can be noted, among the most outstanding results, that the use of new technologies in the classroom is taking a visible role, both from the point of view of the student and the professor for teaching in a collaborative manner and to develop a critical attitude to the current context. Therefore, it is important to establish that, in times of digital humanities teachers must seek to empower the university students so that they acquire skills how to enter critical discourses.

  2. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    International Nuclear Information System (INIS)

    Pecorelli, Alessandra; Bocci, Velio; Acquaviva, Alessandra; Belmonte, Giuseppe; Gardi, Concetta; Virgili, Fabio; Ciccoli, Lucia; Valacchi, Giuseppe

    2013-01-01

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 μg/mL O 3 per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H 2 O 2 ) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ► Endothelial HO1 is upregulated by ozonated plasma ► This activation is induced by NRF2 and it is ERK independent. ► 4HNE and H 2 O 2 are the main molecules involved in this process. ► Ozonated plasma induced a hormetic effect ► Combination of orthodox medicine and ozonated plasma can be a useful treatment

  3. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Pecorelli, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Child Neuropsychiatry Unit, University Hospital, AOUS, Siena (Italy); Bocci, Velio [Department of Physiology, University of Siena (Italy); Acquaviva, Alessandra [Department of Molecular and Developmental Medicine, University of Siena (Italy); Belmonte, Giuseppe [Department of Biomedical Sciences, University of Siena (Italy); Gardi, Concetta [Department of Molecular and Developmental Medicine, University of Siena (Italy); Virgili, Fabio [INRAN, Rome (Italy); Ciccoli, Lucia [Department of Molecular and Developmental Medicine, University of Siena (Italy); Valacchi, Giuseppe, E-mail: giuseppe.valacchi@unife.it [Department of Life Sciences and Biotechnology, University of Ferrara (Italy); Department of Food and Nutrition, Kyung Hee University, Seoul (Korea, Republic of)

    2013-02-15

    During the last decade, it has been shown that the activation of NRF2 and the binding to electrophile-responsive element (EpREs), stimulates the expression of a great number of genes responsible for the synthesis of phase I and phase II proteins, including antioxidants enzymes and heme oxygenase-1 (HO-1). This critical cell response occurs in cardiovascular, degenerative and chronic infective diseases aggravated by a chronic oxidative stress. In our previous reports we have shown that ozonated plasma is able to up-regulate HO-1 expression in endothelial cells. In the present work we investigated a candidate mechanism involved in this process. After treatment with increasing doses of ozonated serum (20, 40 and 80 μg/mL O{sub 3} per mL of serum), a clear dose dependent activation of NRF2 and the subsequent induction of HO-1 and NAD(P)H quinone oxidoreductase 1(NQO1) was observed. This effect was also present when cells were treated with serum and hydrogen peroxide (H{sub 2}O{sub 2}) or serum and 4-hydroxynonenal (4HNE). Moreover, the treatment with ozonated serum was associated with a dose-dependent activation of extracellular-signal-regulated kinases (ERK1/2) and p38 MAP kinases (p38), not directly involved in NRF2 activation. These data, provide a new insight on the mechanism responsible for the induction of HO-1 expression by ozonated serum in the endothelium, and have a practical importance as an expedient approach to the treatment of patients with both effective orthodox drugs and ozonated autohemotherapy, targeted to the restoration of redox homeostasis. - Highlights: ► Endothelial HO1 is upregulated by ozonated plasma ► This activation is induced by NRF2 and it is ERK independent. ► 4HNE and H{sub 2}O{sub 2} are the main molecules involved in this process. ► Ozonated plasma induced a hormetic effect ► Combination of orthodox medicine and ozonated plasma can be a useful treatment.

  4. Einstein's Materialism and Modern Tests of Quantum Mechanics

    Science.gov (United States)

    Vigier, J. P.

    After a presentation of Einstein's and Bohr's antagonistic point of view on the interpretation of Quantum Mechanics an illustration of their conflicting positions in the particular case of Young's double slit experiment is presented. It is then shown that in their most recent form (i. e. time dependent neutron interferometry) these experiments suggest (if one accepts absolute energymomentum conservation in all individual microprocesses) that Einstein was right in the Bohr-Einstein controversy.Translated AbstractEinsteins Materialismus und heutige Tests der QuantenmechanikNach einer Darstellung von Einsteins und Bohrs antagonistischen Standpunkten in der Interpretation der Quantenmechanik werden ihre widersprüchlichen Positionen im speziellen Fall des Youngschen Doppelspaltexperiments dargestellt. Es wird dann gezeigt, daß diese Experimente in ihrer neuesten Form (d. h. zeitabhängige Neutroneninterferometrie) Einstein in der Bohr-Einsteinkontroverse recht gaben (wenn man absolute Energie-Impulserhaltung bei allen individuellen Mikroprozessen annimmt).

  5. Construction of Einstein-Sasaki metrics in D≥7

    International Nuclear Information System (INIS)

    Lue, H.; Pope, C. N.; Vazquez-Poritz, J. F.

    2007-01-01

    We construct explicit Einstein-Kaehler metrics in all even dimensions D=2n+4≥6, in terms of a 2n-dimensional Einstein-Kaehler base metric. These are cohomogeneity 2 metrics which have the new feature of including a NUT-type parameter, or gravomagnetic charge, in addition to..' in addition to mass and rotation parameters. Using a canonical construction, these metrics all yield Einstein-Sasaki metrics in dimensions D=2n+5≥7. As is commonly the case in this type of construction, for suitable choices of the free parameters the Einstein-Sasaki metrics can extend smoothly onto complete and nonsingular manifolds, even though the underlying Einstein-Kaehler metric has conical singularities. We discuss some explicit examples in the case of seven-dimensional Einstein-Sasaki spaces. These new spaces can provide supersymmetric backgrounds in M theory, which play a role in the AdS 4 /CFT 3 correspondence

  6. Monitoring and control of amygdala neurofeedback involves distributed information processing in the human brain.

    Science.gov (United States)

    Paret, Christian; Zähringer, Jenny; Ruf, Matthias; Gerchen, Martin Fungisai; Mall, Stephanie; Hendler, Talma; Schmahl, Christian; Ende, Gabriele

    2018-03-30

    Brain-computer interfaces provide conscious access to neural activity by means of brain-derived feedback ("neurofeedback"). An individual's abilities to monitor and control feedback are two necessary processes for effective neurofeedback therapy, yet their underlying functional neuroanatomy is still being debated. In this study, healthy subjects received visual feedback from their amygdala response to negative pictures. Activation and functional connectivity were analyzed to disentangle the role of brain regions in different processes. Feedback monitoring was mapped to the thalamus, ventromedial prefrontal cortex (vmPFC), ventral striatum (VS), and rostral PFC. The VS responded to feedback corresponding to instructions while rPFC activity differentiated between conditions and predicted amygdala regulation. Control involved the lateral PFC, anterior cingulate, and insula. Monitoring and control activity overlapped in the VS and thalamus. Extending current neural models of neurofeedback, this study introduces monitoring and control of feedback as anatomically dissociated processes, and suggests their important role in voluntary neuromodulation. © 2018 Wiley Periodicals, Inc.

  7. Einstein's Jury: The Race to Test Relativity

    International Nuclear Information System (INIS)

    Ehlers, Juergen

    2007-01-01

    'I know very well that my theory rests on a shaky foundation. What attracts me to it is that it leads to consequences that seem to be accessible to experiment, and it provides a starting point for the theoretical understanding of gravitation', wrote Einstein in 1911. Einstein's Jury by Jeffrey Crelinsten-well documented, well written, and fascinating to read-describes how, from 1909 on, Einstein's two theories of relativity became known to astronomers, and how the predictions made between 1907 and 1915 were received as challenges to observers. The author gives a non-technical account of the efforts made until 1930 to test these predictions; he focuses on two of the three classical tests, namely gravitational redshift and bending of light; the 'jury' consists mainly of American observers-Adams, Campbell, Curtis, Hale, Perrin, St John, Trumpler and others-working with newly built large telescopes, and the Britons Eddington and Evershed. The major steps which, after a long struggle, convinced the majority of astronomers that Einstein was right, are narrated chronologically in rather great detail, especially the work at Lick Observatory, before and after the famous British observation of 1919, on solar eclipses, and the work at Mount Wilson and the Indian Kodaikanal Observatories to extract the gravitational redshift from the complicated spectrum of the sun. The account of the eclipse work which was carried out between 1918 and 1923 by Lick astronomers corrects the impression suggested by many historical accounts that the British expedition alone settled the light-bending question. Apart from these main topics, the anomalous perihelion advance of Mercury and the ether problem are covered. By concentrating on astronomy rather than on physics this book complements the rich but repetitive literature on Einstein and relativity which appeared in connection with the commemoration of Einstein's annus mirabilis, 2005. The well told stories include curiosities such as the

  8. Human case of visceral larva migrans syndrome: pulmonary and hepatic involvement

    Directory of Open Access Journals (Sweden)

    Almatary A. M.

    2016-12-01

    Full Text Available Visceral Larva Migrans (VLM syndrome is commonly caused by larvae of roundworms Toxocara canis or Toxocara cati. Human toxocarosis is a soil-transmitted zoonosis, which may result in partial or general pathological changes in host tissues. We reported a case of 14-year-old boy presented with severe dry cough without dyspnea, mild chest and abdominal pain with general fatigue. Examination of peripheral blood showed marked increase in eosinophils. The chest radiography showed an infiltrative shadow in the lung fields. Chest CT demonstrated multiple opacities in both lungs. Abdominal CT showed multiple low attenuation areas in the liver. Ultrasound guided liver biopsy revealed granulomas with severe eosinophilic infiltration. The boy was treated with albendazole and responded radically. It is worth mentioning that this is the first case of hepato-pulmonary VLM syndrome in Egypt.

  9. Exact solutions of Einstein and Einstein-scalar equations in 2+1 dimensions

    International Nuclear Information System (INIS)

    Virbhadra, K.S.

    1995-01-01

    A nonstatic and circularly symmetric exact solution of the Einstein equations (with a cosmological constant Λ and null fluid) in 2 + 1 dimensions is given. This is a nonstatic generalization of the uncharged spinless Bandos Teitelboim Zanelli (BTZ) metric. For Λ = 0, spacetime is though not flat, the Kretschmann invariant vanishes. The energy, momentum, and power output for this metric are obtained. Further a static and circularly symmetric exact solution of the Einstein-massless scalar equations is given, which has a curvature singularity at r=0 and the scalar field diverges at r=0 as well as at infinity. (author). 12 refs

  10. Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.

    Science.gov (United States)

    Shinsky, Stephen A; Monteith, Kelsey E; Viggiano, Susan; Cosgrove, Michael S

    2015-03-06

    Mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases that are required for metazoan development. MLL1 is the best characterized human SET1 family member, which includes MLL1-4 and SETd1A/B. MLL1 assembles with WDR5, RBBP5, ASH2L, DPY-30 (WRAD) to form the MLL1 core complex, which is required for H3K4 dimethylation and transcriptional activation. Because all SET1 family proteins interact with WRAD in vivo, it is hypothesized they are regulated by similar mechanisms. However, recent evidence suggests differences among family members that may reflect unique regulatory inputs in the cell. Missing is an understanding of the intrinsic enzymatic activities of different SET1 family complexes under standard conditions. In this investigation, we reconstituted each human SET1 family core complex and compared subunit assembly and enzymatic activities. We found that in the absence of WRAD, all but one SET domain catalyzes at least weak H3K4 monomethylation. In the presence of WRAD, all SET1 family members showed stimulated monomethyltransferase activity but differed in their di- and trimethylation activities. We found that these differences are correlated with evolutionary lineage, suggesting these enzyme complexes have evolved to accomplish unique tasks within metazoan genomes. To understand the structural basis for these differences, we employed a "phylogenetic scanning mutagenesis" assay and identified a cluster of amino acid substitutions that confer a WRAD-dependent gain-of-function dimethylation activity on complexes assembled with the MLL3 or Drosophila trithorax proteins. These results form the basis for understanding how WRAD differentially regulates SET1 family complexes in vivo. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  11. Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells.

    Directory of Open Access Journals (Sweden)

    Beatriz Aldaz

    Full Text Available Glioblastoma multiforme (GBM-initiating cells (GICs represent a tumor subpopulation with neural stem cell-like properties that is responsible for the development, progression and therapeutic resistance of human GBM. We have recently shown that blockade of NFκB pathway promotes terminal differentiation and senescence of GICs both in vitro and in vivo, indicating that induction of differentiation may be a potential therapeutic strategy for GBM. MicroRNAs have been implicated in the pathogenesis of GBM, but a high-throughput analysis of their role in GIC differentiation has not been reported. We have established human GIC cell lines that can be efficiently differentiated into cells expressing astrocytic and neuronal lineage markers. Using this in vitro system, a microarray-based high-throughput analysis to determine global expression changes of microRNAs during differentiation of GICs was performed. A number of changes in the levels of microRNAs were detected in differentiating GICs, including over-expression of hsa-miR-21, hsa-miR-29a, hsa-miR-29b, hsa-miR-221 and hsa-miR-222, and down-regulation of hsa-miR-93 and hsa-miR-106a. Functional studies showed that miR-21 over-expression in GICs induced comparable cell differentiation features and targeted SPRY1 mRNA, which encodes for a negative regulator of neural stem-cell differentiation. In addition, miR-221 and miR-222 inhibition in differentiated cells restored the expression of stem cell markers while reducing differentiation markers. Finally, miR-29a and miR-29b targeted MCL1 mRNA in GICs and increased apoptosis. Our study uncovers the microRNA dynamic expression changes occurring during differentiation of GICs, and identifies miR-21 and miR-221/222 as key regulators of this process.

  12. Solitons, gauge theories and the 'great Einstein theorem'

    International Nuclear Information System (INIS)

    Dresden, M.; Chen, S.F.

    1976-01-01

    A field theory is said to be of 'Einstein type' if it has the property that the field equations imply the equations of motion. It is known that general relativity is of Einstein type, it is demonstrated here that the Yang-Mills gauge theory is of Einstein type. The relationship between the singularities in the solutions of the field equations and soliton type is analyzed. (Auth.)

  13. A class of exact solutions to the Einstein field equations

    International Nuclear Information System (INIS)

    Goyal, Nisha; Gupta, R K

    2012-01-01

    The Einstein-Rosen metric is considered and a class of new exact solutions of the field equations for stationary axisymmetric Einstein-Maxwell fields is obtained. The Lie classical approach is applied to obtain exact solutions. By using the Lie classical method, we are able to derive symmetries that are used for reducing the coupled system of partial differential equations into ordinary differential equations. From reduced differential equations we have derived some new exact solutions of Einstein-Maxwell equations. (paper)

  14. Classes of general axisymmetric solutions of Einstein-Maxwell equations

    International Nuclear Information System (INIS)

    Krori, K.D.; Choudhury, T.

    1981-01-01

    An exact solution of the Einstein equations for a stationary axially symmetric distribution of mass composed of all types of multipoles is obtained. Following Ernst (1968), from this vacuum solution the corresponding solution of the coupled Einstein-Maxwell equations is derived. A solution of Einstein-Maxwell fields for a static axially symmetric system composed of all types of multipoles is also obtained. (author)

  15. Interactions of Ultracold Impurity Particles with Bose-Einstein Condensates

    Science.gov (United States)

    2015-06-23

    AFRL-OSR-VA-TR-2015-0141 INTERACTIONS OF ULTRACOLD IMPURITY PARTICLES WITH BOSE- EINSTEIN CONDENSATES Georg Raithel UNIVERSITY OF MICHIGAN Final...SUBTITLE Interactions of ultracold impurity particles with Bose- Einstein Condensates 5a. CONTRACT NUMBER FA9550-10-1-0453 5b. GRANT NUMBER 5c...Interactions of ultracold impurity particles with Bose- Einstein Condensates Contract/Grant #: FA9550-10-1-0453 Reporting Period: 8/15/2010 to 2/14

  16. Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes.

    Directory of Open Access Journals (Sweden)

    Kaitlin M Stimpson

    2010-08-01

    Full Text Available Genome rearrangement often produces chromosomes with two centromeres (dicentrics that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extra-chromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.

  17. Are PrP(C)s involved in some human myelin diseases? Relating experimental studies to human pathology.

    Science.gov (United States)

    Veber, Daniela; Scalabrino, Giuseppe

    2015-12-15

    We have experimentally demonstrated that cobalamin (Cbl) deficiency increases normal cellular prion (PrP(C)) levels in rat spinal cord (SC) and cerebrospinal fluid (CSF), and decreases PrP(C)-mRNA levels in rat SC. Repeated intracerebroventricular administrations of anti-octapeptide repeat-PrP(C)-region antibodies to Cbl-deficient (Cbl-D) rats prevent SC myelin lesions, and the administrations of PrP(C)s to otherwise normal rats cause SC white matter lesions similar to those induced by Cbl deficiency. Cbl positively regulates SC PrP(C) synthesis in rat by stimulating the local synthesis of epidermal growth factor (EGF), which also induces the local synthesis of PrP(C)-mRNAs, and downregulating the local synthesis of tumor necrosis factor(TNF)-α, thus preventing local PrP(C) overproduction. We have clinically demonstrated that PrP(C) levels are increased in the CSF of patients with subacute combined degeneration (SCD), unchanged in the CSF of patients with Alzheimer's disease and amyotrophic lateral sclerosis, and decreased in the CSF and SC of patients with multiple sclerosis (MS), regardless of its clinical course. We conclude that SCD (human and experimental) is a neurological disease due to excess PrP(C) without conformational change and aggregation, that the increase in PrP(C) levels in SCD and Cbl-D polyneuropathy and their decrease in MS CNS make them antipodian myelin diseases in terms of quantitative PrP(C) abnormalities, and that these abnormalities are related to myelin damage in the former, and impede myelin repair in the latter. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. Involvement of DNA polymerase δ in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation

    International Nuclear Information System (INIS)

    Dresler, S.L.; Gowans, B.J.; Robinson-Hill, R.M.; Hunting, D.J.

    1988-01-01

    DNA repair synthesis following UV irradiation of confluent human fibroblasts has a biphasic time course with an early phase of rapid nucleotide incorporation and a late phase of much slower nucleotide incorporation. The biphasic nature of this curve suggests that two distinct DNA repair systems may be operative. Previous studies have specifically implicated DNA polymerase δ as the enzyme involved in DNA repair synthesis occurring immediately after UV damage. In this paper, the authors describe studies of DNA polymerase involvement in DNA repair synthesis in confluent human fibroblasts at late times after UV irradiation. Late UV-induced DNA repair synthesis in both intact and permeable cells was found to be inhibited by aphidicolin, indicating the involvement of one of the aphidicolin-sensitive DNA polymerases, α or δ. In permeable cells, the process was further analyzed by using the nucleotide analogue (butylphenyl)-2'-deoxyguanosine 5'-triphosphate, which inhibits DNA polymerase α several hundred times more strongly than it inhibits DNA polymerase δ. The (butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition curve for late UV-induced repair synthesis was very similar to that for polymerase δ. It appears that repair synthesis at late time after UV irradiation, like repair synthesis at early times, is mediated by DNA polymerase δ

  19. HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway.

    Science.gov (United States)

    González, Mariela Natacha; de Mello, Wallace; Butler-Browne, Gillian S; Silva-Barbosa, Suse Dayse; Mouly, Vincent; Savino, Wilson; Riederer, Ingo

    2017-10-10

    The hepatocyte growth factor (HGF) is required for the activation of muscle progenitor cells called satellite cells (SC), plays a role in the migration of proliferating SC (myoblasts), and is present as a soluble factor during muscle regeneration, along with extracellular matrix (ECM) molecules. In this study, we aimed at determining whether HGF is able to interact with ECM proteins, particularly laminin 111 and fibronectin, and to modulate human myoblast migration. We evaluated the expression of the HGF-receptor c-Met, laminin, and fibronectin receptors by immunoblotting, flow cytometry, or immunofluorescence and used Transwell assays to analyze myoblast migration on laminin 111 and fibronectin in the absence or presence of HGF. Zymography was used to check whether HGF could modulate the production of matrix metalloproteinases by human myoblasts, and the activation of MAPK/ERK pathways was evaluated by immunoblotting. We demonstrated that human myoblasts express c-Met, together with laminin and fibronectin receptors. We observed that human laminin 111 and fibronectin have a chemotactic effect on myoblast migration, and this was synergistically increased when low doses of HGF were added. We detected an increase in MMP-2 activity in myoblasts treated with HGF. Conversely, MMP-2 inhibition decreased the HGF-associated stimulation of cell migration triggered by laminin or fibronectin. HGF treatment also induced in human myoblasts activation of MAPK/ERK pathways, whose specific inhibition decreased the HGF-associated stimulus of cell migration triggered by laminin 111 or fibronectin. We demonstrate that HGF induces ERK phosphorylation and MMP production, thus stimulating human myoblast migration on ECM molecules. Conceptually, these data state that the mechanisms involved in the migration of human myoblasts comprise both soluble and insoluble moieties. This should be taken into account to optimize the design of therapeutic cell transplantation strategies by improving

  20. Spectroscopy of dark soliton states in Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Bongs, K; Burger, S; Hellweg, D; Kottke, M; Dettmer, S; Rinkleff, T; Cacciapuoti, L; Arlt, J; Sengstock, K; Ertmer, W

    2003-01-01

    Experimental and numerical studies of the velocity field of dark solitons in Bose-Einstein condensates are presented. The formation process after phase imprinting as well as the propagation of the emerging soliton are investigated using spatially resolved Bragg spectroscopy of soliton states in Bose-Einstein condensates of 87 Rb. A comparison of experimental data to results from numerical simulations of the Gross-Pitaevskii equation clearly identifies the flux underlying a dark soliton propagating in a Bose-Einstein condensate. The results allow further optimization of the phase imprinting method for creating collective excitations of Bose-Einstein condensates

  1. Heritability of circulating growth factors involved in the angiogenesis in healthy human population.

    Science.gov (United States)

    Pantsulaia, I; Trofimov, S; Kobyliansky, E; Livshits, G

    2004-09-21

    The present study examined the extent of genetic and environmental influences on the populational variation of circulating growth factors (VEGF, EGF) involved in angiogenesis in healthy and ethnically homogeneous Caucasian families. The plasma levels of each of the studied biochemical indices were determined by enzyme-linked immunoassay in 478 healthy individuals aged 18-75 years. Quantitative genetic analysis showed that the VEGF and EGF variation was appreciably attributable to genetic effects, with heritability estimates of 79.9% and 48.4%, respectively. Yet, common environmental factors, shared by members of the same household, also played a significant role (P growth factor-beta 1 (TGF-beta 1) or tissue inhibitors of matrix metalloproteinases 1 (TIMP-1), likewise relevant for angiogenesis. Bivariate analysis revealed significant phenotypic correlations (P < 0.002) between all pairs of variables, thus indicating the possible existence of common genetic and environmental factors. The analysis suggested that the pleiotropic genetic effects were consistently the primary (or even the sole) source of correlation between all pairs of studied molecules. The results of our study affirm the existence of specific and common genetic pathways that commonly determine the greater part of the circulating variation of these molecules.

  2. Web-based tools for microRNAs involved in human cancer.

    Science.gov (United States)

    Mar-Aguilar, Fermín; Rodríguez-Padilla, Cristina; Reséndez-Pérez, Diana

    2016-06-01

    MicroRNAs (miRNAs/miRs) are a family of small, endogenous and evolutionarily-conserved non-coding RNAs that are involved in the regulation of several cellular and functional processes. miRNAs can act as oncogenes or tumor suppressors in all types of cancer, and could be used as prognostic and diagnostic biomarkers. Databases and computational algorithms are behind the majority of the research performed on miRNAs. These tools assemble and curate the relevant information on miRNAs and present it in a user-friendly manner. The current review presents 14 online databases that address every aspect of miRNA cancer research. Certain databases focus on miRNAs and a particular type of cancer, while others analyze the behavior of miRNAs in different malignancies at the same time. Additional databases allow researchers to search for mutations in miRNAs or their targets, and to review the naming history of a particular miRNA. All these databases are open-access, and are a valuable tool for those researchers working with these molecules, particularly those who lack access to an advanced computational infrastructure.

  3. Abnormal binding and disruption in large scale networks involved in human partial seizures

    Directory of Open Access Journals (Sweden)

    Bartolomei Fabrice

    2013-12-01

    Full Text Available There is a marked increase in the amount of electrophysiological and neuroimaging works dealing with the study of large scale brain connectivity in the epileptic brain. Our view of the epileptogenic process in the brain has largely evolved over the last twenty years from the historical concept of “epileptic focus” to a more complex description of “Epileptogenic networks” involved in the genesis and “propagation” of epileptic activities. In particular, a large number of studies have been dedicated to the analysis of intracerebral EEG signals to characterize the dynamic of interactions between brain areas during temporal lobe seizures. These studies have reported that large scale functional connectivity is dramatically altered during seizures, particularly during temporal lobe seizure genesis and development. Dramatic changes in neural synchrony provoked by epileptic rhythms are also responsible for the production of ictal symptoms or changes in patient’s behaviour such as automatisms, emotional changes or consciousness alteration. Beside these studies dedicated to seizures, large-scale network connectivity during the interictal state has also been investigated not only to define biomarkers of epileptogenicity but also to better understand the cognitive impairments observed between seizures.

  4. Involvement of HIF-1α activation in the doxorubicin resistance of human osteosarcoma cells.

    Science.gov (United States)

    Roncuzzi, Laura; Pancotti, Fabia; Baldini, Nicola

    2014-07-01

    Osteosarcoma is the most common primary bone cancer in children and adolescents. Despite aggressive treatment regimens, survival outcomes remain unsatisfactory, particularly in patients with metastatic and/or recurrent disease. Unfortunately, treatment failure is commonly due to the development of chemoresistance, for which the underlying molecular mechanisms remain unclear. The aim of the present study was to investigate the role of hypoxia-inducible factor 1α (HIF‑1α) and its signalling pathways as mediators of drug-resistance in human osteosarcoma. Toward this aim, we established two osteosarcoma cell lines selected for resistance to doxorubicin, a drug of choice in the treatment of this tumour. Our results showed that the multidrug resistance (MDR) phenotype was also mediated by HIF-1α, the most important regulator of cell adaptation to hypoxia. Our data showed that this transcription factor promoted the outward transport of intracellular doxorubicin by activating the P-glycoprotein (P-gp) expression in osteosarcoma cells maintained in normoxic conditions. In addition, it hindered doxorubicin-induced apoptosis by regulating the expression of c-Myc and p21. Finally, we observed that the doxorubicin-resistant cells maintained for 2 months of continuous culture in a drug-free medium, lost their drug-resistance and this effect was associated with the absence of HIF-1α expression. The emerging role of HIF-1α in osteosarcoma biology indicates its use as a valuable therapeutic target.

  5. Perspectives for induced pluripotent stem cell technology: new insights into human physiology involved in somatic mosaicism.

    Science.gov (United States)

    Nagata, Naoki; Yamanaka, Shinya

    2014-01-31

    Induced pluripotent stem cell technology makes in vitro reprogramming of somatic cells from individuals with various genetic backgrounds possible. By applying this technology, it is possible to produce pluripotent stem cells from biopsy samples of arbitrarily selected individuals with various genetic backgrounds and to subsequently maintain, expand, and stock these cells. From these induced pluripotent stem cells, target cells and tissues can be generated after certain differentiation processes. These target cells/tissues are expected to be useful in regenerative medicine, disease modeling, drug screening, toxicology testing, and proof-of-concept studies in drug development. Therefore, the number of publications concerning induced pluripotent stem cells has recently been increasing rapidly, demonstrating that this technology has begun to infiltrate many aspects of stem cell biology and medical applications. In this review, we discuss the perspectives of induced pluripotent stem cell technology for modeling human diseases. In particular, we focus on the cloning event occurring through the reprogramming process and its ability to let us analyze the development of complex disease-harboring somatic mosaicism.

  6. Small GTPases are involved in sprout formation in human granulosa lutein cells.

    Science.gov (United States)

    Franz, Maximilian B; Daube, Stefanie; Keck, Christoph; Sator, Michael; Pietrowski, Detlef

    2013-04-01

    The corpus luteum (CL), develops from the ruptured follicle after gonadotropin stimulation. Based on intracellular reorganization of the cytoskeleton an human chorionic gonadotropin (hCG) dependent sprouting and migration of luteinizing granulosa cells (LGCs) and endothelial cells is observed. Rho-GTPases are shown to be key regulators of cytoskeletal restructuring. In the present study we analyzed the role of Rho-GTPases in the sprouting activity of LGCs. We used the Rho-GTPase-inhibitors Toxin A and -B and the Cdc42-activator Bradykinin in a LGC-spheroid sprouting assay to determine the effect of these modulators in LGCs. Toxin A and Toxin B reduces sprout formation in LGC spheroids. However, the reduction is less than in hCG treated cells. The usage of Bradykinin demonstrates both, a reduction of sprouts in untreated spheroids and an increase of sprouting in previous hCG treated spheroids. The presented results let us suggest that small Rho-GTPases may regulate the sprouting activity of LGCs after stimulation by hCG and that this mechanism may play a role in CL formation.

  7. Factors involved in depletion of glutathione from A549 human lung carcinoma cells: implications for radiotherapy

    International Nuclear Information System (INIS)

    Biaglow, J.E.; Varnes, M.E.; Epp, E.R.; Clark, E.P.

    1984-01-01

    The rate of GSH resynthesis has been measured in plateau phase cultures of A549 human lung carcinoma cells subjected to a fresh medium change. Buthionine sulfoximine (BSO) blocks this resynthesis. Diethyl maleate (DEM) causes a decrease in accumulation of GSH. If DEM is added concurrently with BSO there is a rapid decline in GSH that is maximal in the presence of 0.5 mM DEM. GSH depletion rapidly occurs when BSO is added to log phase cultures which initially are higher in GSH content. Twenty-four hr treatment of A549 cells with BSO results in cells that are more radiosensitive in air and show a slight hypoxic radiation response. A 2 hr treatment with DEM results in some hypoxic sensitization and little increase in the aerobic radiation response. Cells treated simultaneously with BSO + DEM show little increase in the hypoxic radiation response, compared to DEM alone, but are more sensitive under aerobic conditions. Decreased cell survival for aerobically irradiated log phase A549 cells occurs within minutes after addition of a mixture of BSO + DEM. The authors suggest that the enhanced aerobic radiation response is related to an inability of GSH depleted cells to inactivate either peroxy radicals or hydroperoxides that may be produced during irradiation of BSO treated cells. Furthermore, enhancement of the aerobic radiation response may be useful in vivo if normal tissue responses are not also increased

  8. Human biological monitoring for exposure assessment in response to an incident involving hazardous materials.

    Science.gov (United States)

    Scheepers, Paul T J; van Brederode, Nelly E; Bos, Peter M J; Nijhuis, Nicole J; van de Weerdt, Rik H J; van der Woude, Irene; Eggens, Martin L

    2014-12-15

    Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and treatment of exposed individuals from the general population or of emergency responders. Such exposure information may also be used to respond to individual concerns such as questions about a possible relationship between the chemicals released during the incident and health effects. In The Netherlands a guideline was prepared to support early decision-making about the possible use of HBM for exposure assessment during or as soon as possible following a chemical incident. The application of HBM in such an emergency setting is not much different from situations where HBM is normally used but there are some issues that need extra attention such as the choice of the biomarker, the biological media to be sampled, the time point at which biological samples should be collected, the ethics approval and technical implementation of the study protocol and the interpretation and communication of the study results. These issues addressed in the new guideline will support the use of HBM in the management of chemical disasters. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Levels of semenogelin in human spermatozoa decrease during capacitation: involvement of reactive oxygen species and zinc.

    Science.gov (United States)

    de Lamirande, E; Lamothe, G

    2010-07-01

    Semenogelin (Sg), the main protein of human semen coagulum, prevents sperm capacitation. The objective of this study was to examine the role of Sg and its mechanism of action. Sg blocked sperm capacitation triggered by various stimuli, via inhibition of superoxide anion (O(2)*-; luminescence assay) and nitric oxide (NO*; tested using diaminofluorescein) generation. Triton-soluble and -insoluble sperm fractions contained Sg and Sg peptides (immunoblotting), the level of which decreased with initiation of capacitation. This drop was prevented by superoxide dismutase and NO* synthase inhibitor and was reproduced by addition of O(2)*- and NO*. Zinc (Zn(2+)) blocked and a zinc chelator (TPEN) promoted the decline in Sg levels. There was a decreased labelling of Sg on the head in capacitating spermatozoa with the two fixation techniques tested (immunocytochemistry). Reactive oxygen species (ROS) (O(2)*- and NO*) caused, these changes, and zinc prevented them. Spermatozoa quickly internalized Sg upon incubation and Sg was then rapidly degraded in a zinc-inhibitable manner. Sg blocked capacitation mainly via inhibition of ROS generation. Spermatozoa appeared permeable to Sg and processed Sg in a zinc-inhibitable fashion. ROS themselves could promote sperm disposal of Sg which maybe one of the mechanisms that allows initiation of capacitation.

  10. Identification of genes and proteins involved in excision repair of human cells

    International Nuclear Information System (INIS)

    Hoeijmakers, J.H.J.; Westerveld, A.; Van Duin, M.; Vermeulen, W.; Odijk, H.; De Wit, J.; Bootsma, D.

    1986-01-01

    The autosomal, recessive disorder xeroderma pigmentosum (XP) is characterized by extreme sensitivity of the skin to sun exposure and prediposition to skin cancer. The basic defect in most XP patients is thought to reside in an inefficient removal of UV-induced lesions in the DNA by excision repair. The biochemical complexity of this process is amply illustrated by the fact that so far nine complementary groups within this syndrome have been identified. Despite extensive research, none of these genes or proteins involved have been isolated. Using a microinjection assay system the authors identified components in crude cell extracts that transiently correct the defect in (injected) fibroblasts of all excision-deficient XP complementation groups, as indicated by temporary restoration of UV-induced unscheduled DNA synthesis. This correction is complementation group specific, since it is only found when extracts from complementing XP cells are injected. After incubation of extracts with proteinase K the XP-A and KP-G correcting activities were lost, indicating that the complementation is due to proteins. The XP-A correcting protein was found to precipitate between 30 and 60% ammonium sulfate saturation. Furthermore this protein binds to DEAE-cellulose and to (UV-irradiated) double-strand (ds) DNA attached to cellulose. The latter affinity chromatography step allows a considerable purification, since less than 1% of the proteins applied to such columns is retained. It has to be established whether the XP-A correcting proteins binds by itself or via other proteins to the UV-irradiated DNA and whether it also binds to nonirradiated (ds or ss) DNA. Similar experiments with the XP-G correcting protein are in progress

  11. Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)

    Science.gov (United States)

    Spoden, Gilles; Freitag, Kirsten; Husmann, Matthias; Boller, Klaus; Sapp, Martin; Lambert, Carsten; Florin, Luise

    2008-01-01

    Background Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. Methodology/Principal Findings Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. Inhibition of clathrin- and caveolin/raft-dependent endocytic pathways by dominant-negative mutants and siRNA-mediated knockdown, as well as inhibition of dynamin function, did not impair infection. Rather, we provide evidence for involvement of tetraspanin-enriched microdomains (TEMs) in HPV16 endocytosis. Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface. Notably, tetraspanin-specific antibodies and siRNA inhibited HPV16 cell entry and infection, confirming the importance of TEMs for infectious endocytosis of HPV16. Conclusions/Significance Tetraspanins fulfill various roles in the life cycle of a number of important viral pathogens, including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, their involvement in endocytosis of viral particles has not been proven. Our data indicate TEMs as a novel clathrin- and caveolin-independent invasion route for viral pathogens and especially HPV16. PMID:18836553

  12. Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs.

    Directory of Open Access Journals (Sweden)

    Gilles Spoden

    Full Text Available BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16, the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. Inhibition of clathrin- and caveolin/raft-dependent endocytic pathways by dominant-negative mutants and siRNA-mediated knockdown, as well as inhibition of dynamin function, did not impair infection. Rather, we provide evidence for involvement of tetraspanin-enriched microdomains (TEMs in HPV16 endocytosis. Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface. Notably, tetraspanin-specific antibodies and siRNA inhibited HPV16 cell entry and infection, confirming the importance of TEMs for infectious endocytosis of HPV16. CONCLUSIONS/SIGNIFICANCE: Tetraspanins fulfill various roles in the life cycle of a number of important viral pathogens, including human immunodeficiency virus (HIV and hepatitis C virus (HCV. However, their involvement in endocytosis of viral particles has not been proven. Our data indicate TEMs as a novel clathrin- and caveolin-independent invasion route for viral pathogens and especially HPV16.

  13. Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs).

    Science.gov (United States)

    Spoden, Gilles; Freitag, Kirsten; Husmann, Matthias; Boller, Klaus; Sapp, Martin; Lambert, Carsten; Florin, Luise

    2008-10-02

    Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. Inhibition of clathrin- and caveolin/raft-dependent endocytic pathways by dominant-negative mutants and siRNA-mediated knockdown, as well as inhibition of dynamin function, did not impair infection. Rather, we provide evidence for involvement of tetraspanin-enriched microdomains (TEMs) in HPV16 endocytosis. Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface. Notably, tetraspanin-specific antibodies and siRNA inhibited HPV16 cell entry and infection, confirming the importance of TEMs for infectious endocytosis of HPV16. Tetraspanins fulfill various roles in the life cycle of a number of important viral pathogens, including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, their involvement in endocytosis of viral particles has not been proven. Our data indicate TEMs as a novel clathrin- and caveolin-independent invasion route for viral pathogens and especially HPV16.

  14. Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2.

    Science.gov (United States)

    Higashi, Kyohei; Imamura, Masataka; Fudo, Satoshi; Uemura, Takeshi; Saiki, Ryotaro; Hoshino, Tyuji; Toida, Toshihiko; Kashiwagi, Keiko; Igarashi, Kazuei

    2014-01-01

    Polyamine (putrescine, spermidine and spermine) and agmatine uptake by the human organic cation transporter 2 (hOCT2) was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2. The Km values for putrescine and spermidine were 7.50 and 6.76 mM, and the Vmax values were 4.71 and 2.34 nmol/min/mg protein, respectively. Spermine uptake by hOCT2 was not observed at pH 7.4, although it inhibited both putrescine and spermidine uptake. Agmatine was also taken up by hOCT2, with Km value: 3.27 mM and a Vmax value of 3.14 nmol/min/mg protein. Amino acid residues involved in putrescine, agmatine and spermidine uptake by hOCT2 were Asp427, Glu448, Glu456, Asp475, and Glu516. In addition, Glu524 and Glu530 were involved in putrescine and spermidine uptake activity, and Glu528 and Glu540 were weakly involved in putrescine uptake activity. Furthermore, Asp551 was also involved in the recognition of spermidine. These results indicate that the recognition sites for putrescine, agmatine and spermidine on hOCT2 strongly overlap, consistent with the observation that the three amines are transported with similar affinity and velocity. A model of spermidine binding to hOCT2 was constructed based on the functional amino acid residues.

  15. Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2.

    Directory of Open Access Journals (Sweden)

    Kyohei Higashi

    Full Text Available Polyamine (putrescine, spermidine and spermine and agmatine uptake by the human organic cation transporter 2 (hOCT2 was studied using HEK293 cells transfected with pCMV6-XL4/hOCT2. The Km values for putrescine and spermidine were 7.50 and 6.76 mM, and the Vmax values were 4.71 and 2.34 nmol/min/mg protein, respectively. Spermine uptake by hOCT2 was not observed at pH 7.4, although it inhibited both putrescine and spermidine uptake. Agmatine was also taken up by hOCT2, with Km value: 3.27 mM and a Vmax value of 3.14 nmol/min/mg protein. Amino acid residues involved in putrescine, agmatine and spermidine uptake by hOCT2 were Asp427, Glu448, Glu456, Asp475, and Glu516. In addition, Glu524 and Glu530 were involved in putrescine and spermidine uptake activity, and Glu528 and Glu540 were weakly involved in putrescine uptake activity. Furthermore, Asp551 was also involved in the recognition of spermidine. These results indicate that the recognition sites for putrescine, agmatine and spermidine on hOCT2 strongly overlap, consistent with the observation that the three amines are transported with similar affinity and velocity. A model of spermidine binding to hOCT2 was constructed based on the functional amino acid residues.

  16. Involvement of cytochrome epoxygenase metabolites in cutaneous postocclusive hyperemia in humans.

    Science.gov (United States)

    Cracowski, Jean-Luc; Gaillard-Bigot, Florence; Cracowski, Claire; Sors, Claire; Roustit, Matthieu; Millet, Claire

    2013-01-15

    Several mediators contribute to postocclusive reactive hyperemia (PORH) of the skin, including sensory nerves and endothelium-derived hyperpolarizing factors. The main objective of our study was to investigate the specific contribution of epoxyeicosatrienoic acids in human skin PORH. Eight healthy volunteers were enrolled in two placebo-controlled experiments. In the first experiment we studied the separate and combined effects of 6.5 mM fluconazole, infused through microdialysis fibers, and lidocaine/prilocaine cream on skin PORH following 5 min arterial occlusion. In the second experiment we studied the separate and combined effects of 6.5 mM fluconazole and 10 mM N(G)-monomethyl-l-arginine (l-NMMA). Skin blood flux was recorded using two-dimensional laser speckle contrast imaging. Maximal cutaneous vascular conductance (CVC(max)) was obtained following 29 mM sodium nitroprusside perfusion. The PORH peak at the placebo site averaged 66 ± 11%CVC(max). Compared with the placebo site, the peak was significantly lower at the fluconazole (47 ± 10%CVC(max); P < 0.001), lidocaine (29 ± 10%CVC(max); P < 0.001), and fluconazole + lidocaine (30 ± 10%CVC(max); P < 0.001) sites. The effect of fluconazole on the area under the curve was more pronounced. In the second experiment, the PORH peak was significantly lower at the fluconazole site, but not at the l-NMMA or combination site, compared with the placebo site. In addition to sensory nerves cytochrome epoxygenase metabolites, putatively epoxyeicosatrienoic acids, play a major role in healthy skin PORH, their role being more important in the time course rather than the peak.

  17. A third component of the human cytomegalovirus terminase complex is involved in letermovir resistance.

    Science.gov (United States)

    Chou, Sunwen

    2017-12-01

    Letermovir is a human cytomegalovirus (CMV) terminase inhibitor that was clinically effective in a Phase III prevention trial. In vitro studies have shown that viral mutations conferring letermovir resistance map primarily to the UL56 component of the terminase complex and uncommonly to UL89. After serial culture of a baseline CMV laboratory strain under letermovir, mutation was observed in a third terminase component in 2 experiments, both resulting in amino acid substitution P91S in gene UL51 and adding to a pre-existing UL56 mutation. Recombinant phenotyping indicated that P91S alone conferred 2.1-fold increased letermovir resistance (EC50) over baseline, and when combined with UL56 mutation S229F or R369M, multiplied the level of resistance conferred by those mutations by 3.5-7.7-fold. Similarly a combination of UL56 mutations S229F, L254F and L257I selected in the same experiment conferred 54-fold increased letermovir EC50 over baseline, but 290-fold when combined with UL51 P91S. The P91S mutant was not perceptibly growth impaired. Although pUL51 is essential for normal function of the terminase complex, its biological significance is not well understood. Letermovir resistance mutations mapping to 3 separate genes, and their multiplier effect on the level of resistance, suggest that the terminase components interactively contribute to the structure of a letermovir antiviral target. The diagnostic importance of the UL51 P91S mutation arises from its potential to augment the letermovir resistance of some UL56 mutations at low fitness cost. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Towards an Einstein-Podolsky-Rosen paradox between two macroscopic atomic ensembles at room temperature

    OpenAIRE

    He, Q Y; Reid, M D

    2013-01-01

    Experiments have reported the entanglement of two spatially separated macroscopic atomic ensembles at room temperature (Krauter et al 2011 Phys. Rev. Lett. 107 080503; Julsgaard et al 2001 Nature 413 400). We show how an Einstein-Podolsky-Rosen (EPR) paradox is realizable with this experiment. Our proposed test involves violation of an inferred Heisenberg uncertainty principle, which is a sufficient condition for an EPR paradox. This is a stronger test of nonlocality than entanglement. Our pr...

  19. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

    OpenAIRE

    Kanno, Shin-ichiro; Kuzuoka, Hiroyuki; Sasao, Shigeru; Hong, Zehui; Lan, Li; Nakajima, Satoshi; Yasui, Akira

    2007-01-01

    DNA damage causes genome instability and cell death, but many of the cellular responses to DNA damage still remain elusive. We here report a human protein, PALF (PNK and APTX-like FHA protein), with an FHA (forkhead-associated) domain and novel zinc-finger-like CYR (cysteine–tyrosine–arginine) motifs that are involved in responses to DNA damage. We found that the CYR motif is widely distributed among DNA repair proteins of higher eukaryotes, and that PALF, as well as a Drosophila protein with...

  20. Mining the Human Complexome Database Identifies RBM14 as an XPO1-Associated Protein Involved in HIV-1 Rev Function

    OpenAIRE

    Budhiraja, Sona; Liu, Hongbing; Couturier, Jacob; Malovannaya, Anna; Qin, Jun; Lewis, Dorothy E.; Rice, Andrew P.

    2015-01-01

    By recruiting the host protein XPO1 (CRM1), the HIV-1 Rev protein mediates the nuclear export of incompletely spliced viral transcripts. We mined data from the recently described human nuclear complexome to identify a host protein, RBM14, which associates with XPO1 and Rev and is involved in Rev function. Using a Rev-dependent p24 reporter plasmid, we found that RBM14 depletion decreased Rev activity and Rev-mediated enhancement of the cytoplasmic levels of unspliced viral transcripts. RBM14 ...

  1. Man-systems evaluation of moving base vehicle simulation motion cues. [human acceleration perception involving visual feedback

    Science.gov (United States)

    Kirkpatrick, M.; Brye, R. G.

    1974-01-01

    A motion cue investigation program is reported that deals with human factor aspects of high fidelity vehicle simulation. General data on non-visual motion thresholds and specific threshold values are established for use as washout parameters in vehicle simulation. A general purpose similator is used to test the contradictory cue hypothesis that acceleration sensitivity is reduced during a vehicle control task involving visual feedback. The simulator provides varying acceleration levels. The method of forced choice is based on the theory of signal detect ability.

  2. Einstein's idealism and a new kind of space research

    Science.gov (United States)

    Popov, M. A.

    In 1935, Albert Einstein, Boris Podolsky and Nathan Rosen made an attempt to imagine quantum experimental nonsense or some impossible experiment (EPR-experiment) in order to justify their local realism in physics. However, in the mid-1960s, John Bell showed that it is possible to realize this kind of nonsense in laboratory. Today, when EPR-refutation of local realism is routine in modern experimental physics (Clauser and Freedman [1972]; Aspect, Dalibard and Roger [1982]; Zeilinger et al. [1998]), we must; nevertheless, remark that Albert Einstein was not always a realist. As is known, in his Special Relativitz A. Einstein introduced some pure idealistic principle which K. Godel developed in famous "Remark about the relationship between Relativity theorz and Idealistic Philosophy" (1949). Kurt Godel for the first time showed an existence of special-relativistic solipsism, assuming that objective simultaneity in experimental science "loses its objective meaning". Correspondingly, there is only subjective simultaneity, that is provable by calculations with the finite velocity of light and astronomical observations. In particular, this space solipsism means that when we observe the sun, we can see only what happend on Sun 8.33 minutes ago; in other words, we percieve only certain sensations or a certain collections of ideas of the past, but not the present. Similarly, when astronomers observe galaxies estimated to be two billion light years from the Earth, they see these galaxies as they were two billion light years ago not as they are Now. Thus, in accordance with this, we may await that in this context for some pairs of astronomical objects we cannot prove they exist NOW. Moreover, this new kind of space research could be connected with introduction of the Cognitive Dark Matter, or, what is associated with manifold of the large-scale events of the Universe as a whole which are realizing Now, beyond consciousness of the observers-humans. Because we cannot know

  3. Involvement of ERK, Bcl-2 family and caspase 3 in recombinant human activin A-induced apoptosis in A549

    International Nuclear Information System (INIS)

    Wang Baiding; Feng Yuling; Song Xingbo; Liu Qingqing; Ning Yunye; Ou Xuemei; Yang Jie; Zhang Xiaohong; Wen, Fuqiang

    2009-01-01

    Background: Activins are members of the transforming growth factor-β (TGF-β) superfamily. Previous studies have shown that activin A may have a central role in regulating both apoptosis and proliferation. However, direct studies of recombination human activin A on human NSCLC A549 cells have not yet been reported. The purpose of this study was to investigate whether activin A could induce apoptosis in A549 cells and the possible mechanisms via which it worked. Methods: Cellular apoptosis induced by activin A was detected by TUNEL assay and the levels of protein expression were detected by western blot. Results: Recombination human activin A induced apoptosis in human NSCLC A549 cells in a concentrate-dependent manner. Activin A-induced A549 apoptosis was accompanied by the up-regulation of Bax, Bad and Bcl-Xs and down-regulation of Bcl-2. Moreover, activin A treatment increased the expression of its typeII receptors, activated ERK and caspase 3 in A549. These results clearly demonstrate that the induction of apoptosis by activin-A involves multiple cellular/molecular pathways and strongly suggest that pro- and anti-apoptotic Bcl-2 family proteins and caspase 3 participate in activin A-induced apoptotic process in A549 cells. On the other hand, activin A treatment had little effect on primary human small airway epithelial cells (SAECs). Conclusion: Recombination human activin A induced apoptosis in A549 cells, at least partially, through ERK and mitochondrial pathway. The result that activin A did not affect the normal SAEC revealed activin A might be considered as a potential anticancer agent and worthy of further studies

  4. DHX9 helicase is involved in preventing genomic instability induced by alternatively structured DNA in human cells.

    Science.gov (United States)

    Jain, Aklank; Bacolla, Albino; Del Mundo, Imee M; Zhao, Junhua; Wang, Guliang; Vasquez, Karen M

    2013-12-01

    Sequences that have the capacity to adopt alternative (i.e. non-B) DNA structures in the human genome have been implicated in stimulating genomic instability. Previously, we found that a naturally occurring intra-molecular triplex (H-DNA) caused genetic instability in mammals largely in the form of DNA double-strand breaks. Thus, it is of interest to determine the mechanism(s) involved in processing H-DNA. Recently, we demonstrated that human DHX9 helicase preferentially unwinds inter-molecular triplex DNA in vitro. Herein, we used a mutation-reporter system containing H-DNA to examine the relevance of DHX9 activity on naturally occurring H-DNA structures in human cells. We found that H-DNA significantly increased mutagenesis in small-interfering siRNA-treated, DHX9-depleted cells, affecting mostly deletions. Moreover, DHX9 associated with H-DNA in the context of supercoiled plasmids. To further investigate the role of DHX9 in the recognition/processing of H-DNA, we performed binding assays in vitro and chromatin immunoprecipitation assays in U2OS cells. DHX9 recognized H-DNA, as evidenced by its binding to the H-DNA structure and enrichment at the H-DNA region compared with a control region in human cells. These composite data implicate DHX9 in processing H-DNA structures in vivo and support its role in the overall maintenance of genomic stability at sites of alternatively structured DNA.

  5. A one-to-one correspondence between the static Einstein-Maxwell and stationary Einstein-vacuum space-times

    International Nuclear Information System (INIS)

    Chandrasekhar, Subrahmanyan

    1989-01-01

    A one-to-one correspondence is established between the static solutions of the Einstein-Maxwell equations and the stationary solutions of the Einstein-vacuum equations, that enables one to directly write down a solution for the one from a known solution of the other, and conversely, by a simple transcription. The directness of the correspondence is achieved by writing the metric for static Einstein-Maxwell space-times in a coordinate system and a gauge adapted to the two-centre problem and the metric for stationary Einstein-vacuum space-times in a coordinate system and a gauge adapted to black holes with event horizons. (author)

  6. The involvement of proteoglycans in the human plasma prekallikrein interaction with the cell surface.

    Directory of Open Access Journals (Sweden)

    Camila Lopes Veronez

    Full Text Available INTRODUCTION: The aim of this work was to evaluate the role of human plasma prekallikrein assembly and processing in cells and to determine whether proteoglycans, along with high molecular weight kininogen (H-kininogen, influence this interaction. METHODS: We used the endothelial cell line ECV304 and the epithelial cell lines CHO-K1 (wild type and CHO-745 (deficient in proteoglycans. Prekallikrein endocytosis was studied using confocal microscopy, and prekallikrein cleavage/activation was determined by immunoblotting using an antibody directed to the prekallikrein sequence C364TTKTSTR371 and an antibody directed to the entire H-kininogen molecule. RESULTS: At 37°C, prekallikrein endocytosis was assessed in the absence and presence of exogenously applied H-kininogen and found to be 1,418.4±0.010 and 1,070.3±0.001 pixels/cell, respectively, for ECV304 and 1,319.1±0.003 and 631.3±0.001 pixels/cell, respectively, for CHO-K1. No prekallikrein internalization was observed in CHO-745 in either condition. Prekallikrein colocalized with LysoTracker in the absence and presence of exogenous H-kininogen at levels of 76.0% and 88.5%, respectively, for ECV304 and at levels of 40.7% and 57.0%, respectively, for CHO-K1. After assembly on the cell surface, a plasma kallikrein fragment of 53 kDa was predominant in the incubation buffer of all the cell lines studied, indicating specific proteolysis; plasma kallikrein fragments of 48-44 kDa and 34-32 kDa were also detected in the incubation buffer, indicating non-specific cleavage. Bradykinin free H-kininogen internalization was not detected in CHO-K1 or CHO-745 cells at 37°C. CONCLUSION: The prekallikrein interaction with the cell surface is temperature-dependent and independent of exogenously applied H-kininogen, which results in prekallikrein endocytosis promoted by proteoglycans. Prekallikrein proteolysis/activation is influenced by H-kininogen/glycosaminoglycans assembly and controls plasma kallikrein

  7. Einstein's cosmos how Albert Einstein's vision transformed our understanding of space and time

    CERN Document Server

    Kaku, Michio

    2004-01-01

    Few figures loom as large as Albert Einstein in our contemporary culture. It is truly remarkable that a man from such humble beginnings, an unemployed dreamer without a future or a job, who was written off by his professors as a hopeless loser, could to dare to scale the heights he reached. In this enlightening book Michio Kaku reasseses Einstein's work by centering on his three great theories - special relativity, general relativity and the Unified Field Theory. The first yielded the equation E =mc which is now such a fixture in our culture that it is practically a ubiquitous slogan. But the subsequent theories led to the Big Bang theory and have changed irrevocably the way we perceive time and space. Michio Kaku gives a new, refreshing look at the pioneering work of Einstein, giving a more accurate portrayal of his enduring legacy than previous biographies. As today's advanced physicists continue their intense search to fulfill Einstein's most cherished dream, a 'theory of everything', he is recognised as a...

  8. New Einstein-Sasaki and Einstein spaces from Kerr-de Sitter

    International Nuclear Information System (INIS)

    Cvetic, M.; Lue, H.; Pope, C.N.; Page, Don N.

    2009-01-01

    In this paper, which is an elaboration of our results in Phys. Rev. Lett. 95:071101, 2005 (hep-th/0504225), we construct new Einstein-Sasaki spaces L p,q,r 1 ,...,r n-1 in all odd dimensions D = 2n+1 ≥ 5. They arise by taking certain BPS limits of the Euclideanised Kerr-de Sitter metrics. This yields local Einstein-Sasaki metrics of cohomogeneity n, with toric U(1) n+1 principal orbits, and n real non-trivial parameters. By studying the structure of the degenerate orbits we show that for appropriate choices of the parameters, characterised by the (n+1) coprime integers (p,q,r 1 ,...,r n-1 ), the local metrics extend smoothly onto complete and non-singular compact Einstein-Sasaki manifolds L p,q,r 1 ,...,r n-1 . We also construct new complete and non-singular compact Einstein spaces Λ p,q,r 1 ,...,r n in D = 2n+1 that are not Sasakian, by choosing parameters appropriately in the Euclideanised Kerr-de Sitter metrics when no BPS limit is taken.

  9. Unified Maxwell-Einstein and Yang-Mills-Einstein supergravity theories in five dimensions

    International Nuclear Information System (INIS)

    Guenaydin, Murat; Zagermann, Marco

    2003-01-01

    Unified N = 2 Maxwell-Einstein supergravity theories (MESGTs) are supergravity theories in which all the vector fields, including the graviphoton, transform in an irreducible representation of a simple global symmetry group of the Lagrangian. As was established long time ago, in five dimensions there exist only four unified Maxwell-Einstein supergravity theories whose target manifolds are symmetric spaces. These theories are defined by the four simple euclidean Jordan algebras of degree three. In this paper, we show that, in addition to these four unified MESGTs with symmetric target spaces, there exist three infinite families of unified MESGTs as well as another exceptional one. These novel unified MESGTs are defined by non-compact (minkowskian) Jordan algebras, and their target spaces are in general neither symmetric nor homogeneous. The members of one of these three infinite families can be gauged in such a way as to obtain an infinite family of unified N = 2 Yang-Mills-Einstein supergravity theories, in which all vector fields transform in the adjoint representation of a simple gauge group of the type SU(N,1). The corresponding gaugings in the other two infinite families lead to Yang-Mills-Einstein supergravity theories coupled to tensor multiplets. (author)

  10. Lattice solitons in Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Efremidis, Nikolaos K.; Christodoulides, Demetrios N.

    2003-01-01

    We systematically study the properties of lattice solitons in Bose-Einstein condensates with either attractive or repulsive atom interactions. This is done, by exactly solving the mean-field Gross-Pitaevskii equation in the presence of a periodic potential. We find new families of lattice soliton solutions that are characterized by the position of the energy eigenvalue within the associated band structure. These include lattice solitons in condensates with either attractive or repulsive atom interactions that exist in finite or semi-infinite gaps, as well as nonlinear modes that exhibit atomic population cutoffs

  11. Einstein-Yang-Mills-Lorentz black holes

    Energy Technology Data Exchange (ETDEWEB)

    Cembranos, Jose A.R.; Gigante Valcarcel, Jorge [Universidad Complutense de Madrid, Departamento de Fisica Teorica I, Madrid (Spain)

    2017-12-15

    Different black hole solutions of the coupled Einstein-Yang-Mills equations have been well known for a long time. They have attracted much attention from mathematicians and physicists since their discovery. In this work, we analyze black holes associated with the gauge Lorentz group. In particular, we study solutions which identify the gauge connection with the spin connection. This ansatz allows one to find exact solutions to the complete system of equations. By using this procedure, we show the equivalence between the Yang-Mills-Lorentz model in curved space-time and a particular set of extended gravitational theories. (orig.)

  12. Einstein equations and Fermion degrees of freedom

    International Nuclear Information System (INIS)

    Luetz, E.F.; Vasconcellos, C.A.Z.

    2001-01-01

    When Dirac derived the special relativistic quantum equation which brings his name, it became evident that the spin is a consequence of the space-time geometry. However, taking gravity into account (as for, instance, in the study of neutron stars), most authors do not take into account the relation between hyperbolic geometry and spin and derive an Einstein equation which implicitly takes into account only boson degrees of freedom. In this work we introduce a consistent quantum general relativistic formalism which allows us to study the effects of the existence of fermion degrees of freedom. (author)

  13. Einstein equations and Fermion degrees of freedom

    Energy Technology Data Exchange (ETDEWEB)

    Luetz, E.F.; Vasconcellos, C.A.Z. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Inst. de Fisica

    2001-07-01

    When Dirac derived the special relativistic quantum equation which brings his name, it became evident that the spin is a consequence of the space-time geometry. However, taking gravity into account (as for, instance, in the study of neutron stars), most authors do not take into account the relation between hyperbolic geometry and spin and derive an Einstein equation which implicitly takes into account only boson degrees of freedom. In this work we introduce a consistent quantum general relativistic formalism which allows us to study the effects of the existence of fermion degrees of freedom. (author)

  14. Bose-Einstein Condensation in Complex Networks

    International Nuclear Information System (INIS)

    Bianconi, Ginestra; Barabasi, Albert-Laszlo

    2001-01-01

    The evolution of many complex systems, including the World Wide Web, business, and citation networks, is encoded in the dynamic web describing the interactions between the system's constituents. Despite their irreversible and nonequilibrium nature these networks follow Bose statistics and can undergo Bose-Einstein condensation. Addressing the dynamical properties of these nonequilibrium systems within the framework of equilibrium quantum gases predicts that the 'first-mover-advantage,' 'fit-get-rich,' and 'winner-takes-all' phenomena observed in competitive systems are thermodynamically distinct phases of the underlying evolving networks

  15. An exact solution in Einstein-Cartan

    International Nuclear Information System (INIS)

    Roque, W.L.

    1982-01-01

    The exact solution of the field equations of the Einstein-Cartan theory is obtained for an artificial dust of radially polarized spins, with spherical symmetry and static. For a best estimation of the effect due the spin, the energy-momentum metric tensor is considered null. The gravitational field dynamics is studied for several torsion strengths, through the massive and spinless test-particle moviment, in particular for null torsion Schwarzschild solutions is again obtained. It is observed that the gravitational effects related to the torsin (spin) sometimes are attractives sometimes are repulsives, depending of the torsion values and of the test-particle position and velocity. (L.C.) [pt

  16. Wormholes in Einstein-Born-Infeld Gravity

    Directory of Open Access Journals (Sweden)

    Kim Jin Young

    2018-01-01

    Full Text Available We introduce a new approach to construct wormholes without introducing exotic matters in Einstein-Born-Infeld gravity with a cosmological constant. Contary to the conventional approach, the throat is located at the place where the solutions can be joined smoothly. The metric and its derivatives are continuous so that the exotic matters are not needed there. The exoticity of the energy-momentum tensor is not essential to sustain the wormhole. We also present a method to check the stability of wormholes in the new approach.

  17. Bose-Einstein condensation in real space

    International Nuclear Information System (INIS)

    Valencia, J.J.; Llano, M. de; Solis, M.A.

    2004-01-01

    We show how Bose-Einstein condensation (BEC) occurs not only in momentum space but also in coordinate (or real) space. Analogies between the isotherms of a van der Waals classical gas of extended (or finite-diameter) identical atoms and the point (or zero-diameter) particles of an ideal BE gas allow concluding that, in contrast with the classical case, the volume per particle vanishes in the pure BE condensate phase precisely because the boson diameters are zero. Thus a BE condensate forms in real space without exhibiting a liquid branch as does the classical gas. (Author)

  18. Quenching of Einstein-coefficients by photons

    International Nuclear Information System (INIS)

    Aumayr, F.; Skinner, C.H.; Suckewer, S.; Princeton Univ., NJ; Lee, W.

    1991-02-01

    Experimental evidence is presented for the change of Einstein's A-coefficients for spontaneous transitions from the upper laser level of an argon ion laser discharge due to the presence of the high-intensity laser flux. To demonstrate that this quenching effect cannot be attributed to a reduction in self-absorption of the strong spontaneous emission line, absorption and line profile measurements have been performed. Computer modelling of the reduction of self absorption due to Rabi splitting also indicated that this effect is too small to explain the observed quenching of spontaneous line emissions. 13 refs., 11 figs

  19. Quenching of Einstein-coefficients by photons

    International Nuclear Information System (INIS)

    Aumayr, F.; Lee, W.; Skinner, C.H.; Suckewer, S.

    1991-03-01

    Experimental evidence is presented for the change of Einstein's A- coefficients for spontaneous transitions from the upper laser level of argon ion laser discharge due to the presence of the high- intensity laser flux. To demonstrate that this quenching effect cannot be attributed to a reduction in self-absorption of the strong spontaneous emission line, absorption and line profile measurements have been performed. Computer modelling of the reduction of self absorption due to Rabi splitting also indicated that this effect is too small to explain the observed quenching of spontaneous line emissions. 13 refs., 11 figs

  20. Neutrino fields in Einstein-Cartan theory

    International Nuclear Information System (INIS)

    Griffiths, J.B.

    1981-01-01

    The spin-coefficient formalism presented elsewhere is here applied to classical neutrino fields in Einstein-Cartan theory. It is shown that the neutrino current vector is tangent to an expansion-free null geodesic congruence with constant and equal twist and shear, which vanish if and only if the congruence is a repeated principal null congruence of the gravitational field. The geodesics are both extremals and autoparallels. All exact solutions for the case of pure radiation fields are obtained, and it is shown that the only possible ghost solutions have a plane wave metric. (author)

  1. The simplest group of Einstein supergravity

    International Nuclear Information System (INIS)

    Ogievetsky, V.I.; Sokatchev, E.S.

    1979-01-01

    The simplest supergroup of Einstein supergravity is considered. It is the complex supergroup of general coordinate transformations in left- and right-handed chiral conjugated superspaces restricted by the condition of left- and right- supervolume-preservation. The real part of the vector coordinate of the superspace is identified with the space-time coordinate xsup(m) and the imaginary one, with the axial gravitational superfield Hsup(m) (x, theta, anti theta). The transformations of the field components of Hsup(m) are studied in detail. The approach described is the geometrical basis of the so-called ''tensor calculus''

  2. Internal Einstein spaces and symmetry breaking

    International Nuclear Information System (INIS)

    Coquereaux, R.

    1984-01-01

    We first define a generalised gauge invariant Yang-Mills Lagrangian: the Killing metric -Ksub(αβ) on the group is replaced by a more general metric hsub(αβ)(x); the field hsub(αβ)(x) -a scalar from the space time point of view- is then covariantly coupled to the gauge field Asub(μ)sup(α) and is also self-coupled via a natural scalar potential (no parameters). Non trivial saddle points of this scalar potential, correspond to non standard Einstein metrics on the group C. the associated shifts lead to an entirely computable mass spectrum for the gauge field

  3. Einstein and the Changing Worldviews of Physics

    CERN Document Server

    Lehner, Christoph; Schemmel, Matthias

    2012-01-01

    This volume reviews conceptual conflicts at the foundations of physics now and in the past century. The focus is on the conditions and consequences of Einstein's pathbreaking achievements that sealed the decline of the classical notions of space, time, radiation, and matter, and resulted in the theory of relativity. Particular attention is paid to the implications of conceptual conflicts for scientific views of the world at large, thus providing the basis for a comparison of the demise of the mechanical worldview at the turn of the 20th century with the challenges presented by cosmology at the

  4. Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells.

    Science.gov (United States)

    Kim, Hyun Ji; Lee, Hye Ja; Park, Mi Kyung; Gang, Kyung Jin; Byun, Hyun Jung; Park, Jeong Ho; Kim, Mi Kyung; Kim, Soo Youl; Lee, Chang Hoon

    2014-05-01

    Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesis, though its molecular mechanism in melanogenesis remains unclear. In the present study, we investigated the effect of CTM on melanin production using ELISA reader and the expression of proteins involved in melanogenesis by Western blotting, and examined the involvement of transglutaminase-2 (Tgase-2) in SK-MEL-2 human melanoma cells by gene silencing. In the results, CTM dose-dependently suppressed melanin production and dendrite extension in α-MSH-induced melanogenesis of SK-MEL-2 human melanoma cells. CTM also suppressed α-MSH-induced chemotactic migration as well as the expressions of melanogenesis factors TRP-1, TRP-2 and MITF in α-MSH-treated SK-MEL-2 cells. Meanwhile, gene silencing of Tgase-2 suppressed dendrite extension and the expressions of TRP-1 and TRP-2 in α-MSH-treated SK-MEL-2 cells. Overall, these findings suggested that CTM suppresses α-MSH-induced melanogenesis via Tgase-2 inhibition and that therefore, Tgase-2 might be a new target in hyperpigmentation disorder therapy.

  5. The Einstein Genome Gateway using WASP - a high throughput multi-layered life sciences portal for XSEDE.

    Science.gov (United States)

    Golden, Aaron; McLellan, Andrew S; Dubin, Robert A; Jing, Qiang; O Broin, Pilib; Moskowitz, David; Zhang, Zhengdong; Suzuki, Masako; Hargitai, Joseph; Calder, R Brent; Greally, John M

    2012-01-01

    Massively-parallel sequencing (MPS) technologies and their diverse applications in genomics and epigenomics research have yielded enormous new insights into the physiology and pathophysiology of the human genome. The biggest hurdle remains the magnitude and diversity of the datasets generated, compromising our ability to manage, organize, process and ultimately analyse data. The Wiki-based Automated Sequence Processor (WASP), developed at the Albert Einstein College of Medicine (hereafter Einstein), uniquely manages to tightly couple the sequencing platform, the sequencing assay, sample metadata and the automated workflows deployed on a heterogeneous high performance computing cluster infrastructure that yield sequenced, quality-controlled and 'mapped' sequence data, all within the one operating environment accessible by a web-based GUI interface. WASP at Einstein processes 4-6 TB of data per week and since its production cycle commenced it has processed ~ 1 PB of data overall and has revolutionized user interactivity with these new genomic technologies, who remain blissfully unaware of the data storage, management and most importantly processing services they request. The abstraction of such computational complexity for the user in effect makes WASP an ideal middleware solution, and an appropriate basis for the development of a grid-enabled resource - the Einstein Genome Gateway - as part of the Extreme Science and Engineering Discovery Environment (XSEDE) program. In this paper we discuss the existing WASP system, its proposed middleware role, and its planned interaction with XSEDE to form the Einstein Genome Gateway.

  6. A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

    Science.gov (United States)

    Hong, Zehui; Jiang, Jie; Lan, Li; Nakajima, Satoshi; Kanno, Shin-ichiro; Koseki, Haruhiko; Yasui, Akira

    2008-01-01

    DNA double-strand breaks (DSBs) represent the most toxic DNA damage arisen from endogenous and exogenous genotoxic stresses and are known to be repaired by either homologous recombination or nonhomologous end-joining processes. Although many proteins have been identified to participate in either of the processes, the whole processes still remain elusive. Polycomb group (PcG) proteins are epigenetic chromatin modifiers involved in gene silencing, cancer development and the maintenance of embryonic and adult stem cells. By screening proteins responding to DNA damage using laser micro-irradiation, we found that PHF1, a human homolog of Drosophila polycomb-like, Pcl, protein, was recruited to DSBs immediately after irradiation and dissociated within 10 min. The accumulation at DSBs is Ku70/Ku80-dependent, and knockdown of PHF1 leads to X-ray sensitivity and increases the frequency of homologous recombination in HeLa cell. We found that PHF1 interacts physically with Ku70/Ku80, suggesting that PHF1 promotes nonhomologous end-joining processes. Furthermore, we found that PHF1 interacts with a number of proteins involved in DNA damage responses, RAD50, SMC1, DHX9 and p53, further suggesting that PHF1, besides the function in PcG, is involved in genome maintenance processes. PMID:18385154

  7. Einstein's Unification: General Relativity and the Quest for Mathematical Naturalness

    NARCIS (Netherlands)

    van Dongen, J.A.E.F.

    2002-01-01

    The aim of the thesis has been to understand Einstein's development and see the historical coherence in his later attitude in physics. The lesson we learned has been straightforward: the key that unlocks the later Einstein lies in the road by which he arrived at the field equations of general

  8. [Photoeffects, Einstein's light quanta and the history of their acceptance].

    Science.gov (United States)

    Wiederkehr, Karl Heinrich

    2006-01-01

    It is generally supposed, that the discovery of the efficacy-quantum by Planck was the impetus to Einstein's hypothesis of lightquanta. With its help Einstein could explain the external light-electrical effect. But even years before Einstein had worked at the photoeffect and already made experiments on it. For that reason the article gives a short survey about the history of the lightelectric effects. Lenard's basical work about the release of the photoelectrons is dealt with in detail, without which Einstein would scarcely have found his lightquanta. Furthermore it is shown how difficult it was for the physicists to give up--at least partially--the traditional view of the undulation-nature of light, and how they searched to explain the great energies of the photoelectrons. On the other side it is set forth how Einstein's formula of lightquanta was gradually confirmed. The tragical development of Einstein's personal relations with Johannes Stark and Philipp Lenard are briefly described. Stark was one of the few who supported Einstein's ideas at the beginning. Only with the Compton-effect, which could only be quantitatively interpreted by means of lightquanta and the special theory of relativity 1923, the way was free for the general acceptance of the lightquanta. Einstein did not agree to the obtained dualism of undulation and corpuscle; he had a different solution in mind about the fusion of the two forms of appearance of light.

  9. Albert Einstein's 1916 Review Article on General Relativity

    OpenAIRE

    Sauer, Tilman

    2004-01-01

    The first comprehensive overview of the final version of the general theory of relativity was published by Einstein in 1916 after several expositions of preliminary versions and latest revisions of the theory in November 1915. A historical account of this review paper is given, of its prehistory, including a discussion of Einstein's collaboration with Marcel Grossmann, and of its immediate reception.

  10. From the Classroom to Washington: Einsteins on Education Reform

    Science.gov (United States)

    Hughes, Kent H., Ed.; Byers, Elizabeth A., Ed.

    2010-01-01

    The Woodrow Wilson International Center for Scholars was delighted to host a group of current and former Albert Einstein Distinguished Educator Fellows as they celebrated the 20th anniversary of the fellowship program. Outstanding math and science teachers in America's K-12 schools, the Einstein Fellows spend a year (or sometimes two) working on…

  11. Optical absorption in a degenerate Bose-Einstein gas

    International Nuclear Information System (INIS)

    Yip, S.K.

    2002-01-01

    We develop a theory on optical absorption in a dilute Bose-Einstein gas at low temperatures. This theory is motivated by the Bogoliubov theory of elementary excitations for this system, and takes into account explicitly the modification of the nature and dispersion of elementary excitations due to Bose-Einstein condensation. Our results show important differences from existing theories

  12. Validity of the Einstein Relation in Disordered Organic Semiconductors

    NARCIS (Netherlands)

    Wetzelaer, G. A. H.; Koster, L. J. A.; Blom, P. W. M.

    2011-01-01

    It is controversial whether energetic disorder in semiconductors is already sufficient to violate the classical Einstein relation, even in the case of thermal equilibrium. We demonstrate that the Einstein relation is violated only under nonequilibrium conditions due to deeply trapped carriers, as in

  13. Calculation of thermodynamic properties of finite Bose-Einstein systems

    NARCIS (Netherlands)

    Borrmann, P.; Harting, J.D.R.; Mülken, O.; Hilf, E.

    1999-01-01

    We derive an exact recursion formula for the calculation of thermodynamic functions of finite systems obeying Bose-Einstein statistics. The formula is applicable for canonical systems where the particles can be treated as noninteracting in some approximation, e.g., like Bose-Einstein condensates in

  14. Superenergy tensors in the Einstein-Cartan theory of gravitation

    International Nuclear Information System (INIS)

    Garecki, J.

    1981-01-01

    In this paper we study systematically a generalization of the notion of ''superenergy tensors'' which has been introduced previously in the framework of the General Theory of Relativity on the Einstein-Cartan Theory of Gravitation. It is shown, by means of expansion in the normal coordinate system that the generalization is analytically simple only for the Einstein formulation of conservation laws. (author)

  15. On an uncorrelated jet model with Bose-Einstein statistics

    International Nuclear Information System (INIS)

    Bilic, N.; Dadic, I.; Martinis, M.

    1978-01-01

    Starting from the density of states of an ideal Bose-Einstein gas, an uncorrelated jet model with Bose-Einstein statistics has been formulated. The transition to continuum is based on the Touschek invariant measure. It has been shown that in this model average multiplicity increases logarithmically with total energy, while the inclusive distribution shows ln s violation of scaling. (author)

  16. Ludwig Boltzmann, Albert Einstein and Franz Joseph

    International Nuclear Information System (INIS)

    Broda, E.

    1983-01-01

    Under the Emperor Francis Joseph (1848-1916) the natural sciences were less weIl supported in Austria than in other countries of Europe. This is explained by the fact that the German speaking middle classes accepted the preeminence of the feudal forces with their antiscientific attitude. The reason for this readiness to subordination was that those middle classes feIt threatened in their relatively favourable situation by Slavs and Latins. Francis Joseph was the typical representative of the aristocracy. Personally, he did his duty conscientiously and was not corrupt, but progressive ideas and scientific thought were alien to him. From his desk he treated Boltzmann benevolently, but he had no wish to meet personally the greatest mind of the Empire or in any respect to ask his views. Another famous subject of the Emperor, Albert Einstein, was apparently ignored altogether. The structural weakness of Austria, due to the national problems, led to immobilism in her scientific life, but also, up to a point, to tolerance. The impression of Victor Adler on Einstein is considered in this historical context. (author) [de

  17. Gravity Before Einstein and Schwinger Before Gravity

    Science.gov (United States)

    Trimble, Virginia L.

    2012-05-01

    Julian Schwinger was a child prodigy, and Albert Einstein distinctly not; Schwinger had something like 73 graduate students, and Einstein very few. But both thought gravity was important. They were not, of course, the first, nor is the disagreement on how one should think about gravity that is being highlighted here the first such dispute. The talk will explore, first, several of the earlier dichotomies: was gravity capable of action at a distance (Newton), or was a transmitting ether required (many others). Did it act on everything or only on solids (an odd idea of the Herschels that fed into their ideas of solar structure and sunspots)? Did gravitational information require time for its transmission? Is the exponent of r precisely 2, or 2 plus a smidgeon (a suggestion by Simon Newcomb among others)? And so forth. Second, I will try to say something about Scwinger's lesser known early work and how it might have prefigured his "source theory," beginning with "On the Interaction of Several Electrons (the unpublished, 1934 "zeroth paper," whose title somewhat reminds one of "On the Dynamics of an Asteroid," through his days at Berkeley with Oppenheimer, Gerjuoy, and others, to his application of ideas from nuclear physics to radar and of radar engineering techniques to problems in nuclear physics. And folks who think good jobs are difficult to come by now might want to contemplate the couple of years Schwinger spent teaching elementary physics at Purdue before moving on to the MIT Rad Lab for war work.

  18. On Certain Conceptual Anomalies in Einstein's Theory of Relativity

    Directory of Open Access Journals (Sweden)

    Crothers S. J.

    2008-01-01

    Full Text Available There are a number of conceptual anomalies occurring in the Standard exposition of Einstein's Theory of Relativity. These anomalies relate to issues in both mathematics and in physics and penetrate to the very heart of Einstein's theory. This paper reveals and amplifies a few such anomalies, including the fact that Einstein's field equations for the so-called static vacuum configuration, $R_{mu u} = 0$, violates his Principle of Equivalence, and is therefore erroneous. This has a direct bearing on the usual concept of conservation of energy for the gravitational field and the conventional formulation for localisation of energy using Einstein's pseudo-tensor. Misconceptions as to the relationship between Minkowski spacetime and Special Relativity are also discussed, along with their relationships to the pseudo-Riemannian metric manifold of Einstein's gravitational field, and their fundamental geometric structures pertaining to spherical symmetry.

  19. Einstein, cientista e filósofo?

    Directory of Open Access Journals (Sweden)

    Michel Paty

    1993-12-01

    Full Text Available A física, como prática filosófica, designa a escolha de ângulo de abordagem sob o qual é possível perceber características fundamentais da física. Assumimos que os papéis do físico e do filósofo não são tão demarcados e que a tarefa do físico é inseparavelmente enunciar a significação dos conceitos, estabelecendo sua identificação lógico-matemática, e ligá-los à experiência. Nesta perspectiva, a análise da atividade de Einstein, especialmente o exame da gênese da teoria da Relatividade restrita e das significações nos conceitos e enunciados da Relatividade restrita e geral nos leva à afirmação da tese expressa no epíteto Einstein filósofo. Para este percurso foi necessário então a crítica da corrente filosófica - Círculo de Viena - aparentemente mais próxima da atividade einsteniana, mas que só o tomou como referência na condição de físico. Em especial é analisada, e recusada, a tese de Reichenbach da separação entre o contexto de justificativa - ao qual se aplica a análise filosófica - e o contexto de descoberta - relegado exclusivamente ao campo da psicologia. Para esta crítica buscamos, nos processos de descoberta, não uma rígida estrutura lógica mas a noção mais ampla de racionalidade.Physics as philosophical practice points out the option of an approach which enables us to perceive fundamental features of physics. We maintain that the physicist and the philosopher play roles not so disjuncted and that the physicist's task is as much to enunciate the meaning of the concepts, establishing its logical and mathematic identification, as to link them to experience. With this point of view we analyze Einstein's activity with emphasis on the rise of Special Relativity Theory and the meaning of the concepts of Special and General Relativity. This analysis carries us to the thesis expressed in the title Einstein, philosopher. To this way we have needed to criticize that philosophical movement

  20. BOOK REVIEW: A Student's Guide to Einstein's Major Papers A Student's Guide to Einstein's Major Papers

    Science.gov (United States)

    Janssen, Michel

    2013-12-01

    The core of this volume is formed by four chapters (2-5) with detailed reconstructions of the arguments and derivations in four of Einstein's most important papers, the three main papers of his annus mirabilis 1905 (on the light quantum, Brownian motion, and special relativity) and his first systematic exposition of general relativity of 1916. The derivations are given in sufficient detail and in sufficiently modernized notation (without any serious distortion of the originals) for an undergraduate physics major to read and understand them with far less effort than it would take him or her to understand (English translations of) Einstein's original papers. Each of these four papers is accompanied by a detailed introduction, which covers the conceptual development of the relevant field prior to Einstein's contribution to it and corrects some of the myths surrounding these papers that still have not been fully eradicated among physicists. (One quibble: though Kennedy correctly points out that the goal of the light quantum paper was not to explain the photoelectric effect, it is also not quite right to say that 'it was written to explain the Wien region of blackbody radiation' (p. xv). Einstein used this explanatory feat as the central argument for his light quantum hypothesis.) These four chapters then are the most valuable part of the volume. They could be used, independently of one another, but preferably in conjunction with Einstein's original texts, in courses on quantum mechanics, statistical mechanics, electrodynamics, and general relativity, respectively, to add a historical component to such courses. As a historian of science embedded in a physics department who is regularly called upon to give guest lectures in such courses on the history of their subjects, I can highly recommend the volume for this purpose. However, I would not adopt this volume as (one of) the central text(s) for a course on the history of modern physics. For one thing, chapter 1, which in

  1. Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH.

    Science.gov (United States)

    Eipeldauer, Stefan; Thomas, Anita; Hoechtl-Lee, Leonard; Kecht, Mathias; Binder, Harald; Koettstorfer, Julia; Gregori, Markus; Sarahrudi, Kambiz

    2014-01-01

    Sonic Hedgehog (SHH) is a new signalling pathway in bone repair. Evidence exist that SHH pathway plays a significant role in vasculogenesis and limb development during embryogenesis. Some in vitro and animal studies has already proven its potential for bone regeneration. However, no data on the role of SHH in the human fracture healing have been published so far. Seventy-five patients with long bone fractures were included into the study and divided in 2 groups. First group contained 69 patients with normal fracture healing. Four patients with impaired fracture healing formed the second group. 34 volunteers donated blood samples as control. Serum samples were collected over a period of 1 year following a standardized time schedule. In addition, SHH levels were measured in fracture haematoma and serum of 16 patients with bone fractures. Fracture haematoma and patients serum both contained lower SHH concentrations compared to control serum. The comparison between the patients' serum SHH level and the control serum revealed lower levels for the patients at all measurement time points. Significantly lower concentrations were observed at weeks 1 and 2 after fracture. SHH levels were slightly decreased in patients with impaired fracture healing without statistical significance. This is the first study to report local and systemic concentration of SHH in human fracture healing and SHH serum levels in healthy adults. A significant reduction of the SHH levels during the inflammatory phase of fracture healing was found. SHH concentrations in fracture haematoma and serum were lower than the concentration in control serum for the rest of the healing period. Our findings indicate that there is no relevant involvement of SHH in human fracture healing. Fracture repair process seem to reduce the SHH level in human. Further studies are definitely needed to clarify the underlying mechanisms.

  2. Can the Stark-Einstein law resolve the measurement problem from an animate perspective?

    Science.gov (United States)

    Thaheld, Fred H

    2015-09-01

    Analysis of the Stark-Einstein law as it applies to the retinal molecule, which is part of the rhodopsin molecule within the rod cells of the retina, reveals that it may provide the solution to the measurement problem from an animate perspective. That it represents a natural boundary where the Schrödinger equation or wave function automatically goes from linear to nonlinear while remaining in a deterministic state. It will be possible in the near future to subject this theory to empirical tests as has been previously proposed. This analysis provides a contrast to the many decades well studied and debated inanimate measurement problem and would represent an addition to the Stark-Einstein law involving information carried by the photon. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  3. Einstein's cosmology review of 1933: a new perspective on the Einstein-de Sitter model of the cosmos

    Science.gov (United States)

    O'Raifeartaigh, Cormac; O'Keeffe, Michael; Nahm, Werner; Mitton, Simon

    2015-09-01

    We present a first English translation and analysis of a little-known review of relativistic cosmology written by Albert Einstein in late 1932. The article, which was published in 1933 in a book of Einstein papers translated into French, contains a substantial review of static and dynamic relativistic models of the cosmos, culminating in a discussion of the Einstein-de Sitter model. The article offers a valuable contemporaneous insight into Einstein's cosmology in the early 1930s and confirms that his interest lay in the development of the simplest model of the cosmos that could account for observation. The article also confirms that Einstein did not believe that simplified relativistic models could give an accurate description of the early universe.

  4. Einstein boundary conditions in relation to constraint propagation for the initial-boundary value problem of the Einstein equations

    International Nuclear Information System (INIS)

    Frittelli, Simonetta; Gomez, Roberto

    2004-01-01

    We show how the use of the normal projection of the Einstein tensor as a set of boundary conditions relates to the propagation of the constraints, for two representations of the Einstein equations with vanishing shift vector: the Arnowitt-Deser-Misner formulation, which is ill posed, and the Einstein-Christoffel formulation, which is symmetric hyperbolic. Essentially, the components of the normal projection of the Einstein tensor that act as nontrivial boundary conditions are linear combinations of the evolution equations with the constraints that are not preserved at the boundary, in both cases. In the process, the relationship of the normal projection of the Einstein tensor to the recently introduced 'constraint-preserving' boundary conditions becomes apparent

  5. Are lipid disorders involved in the predominance of human T-lymphotropic virus-1 infections in women?

    Directory of Open Access Journals (Sweden)

    Luciana Debortoli de Carvalho

    2015-12-01

    Full Text Available Abstract INTRODUCTION : The human T-lymphotropic virus-1 (HTLV-1 is associated with chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP, a chronic inflammatory disease. Disturbances in lipid metabolism are involved in inflammatory and demyelinating diseases. METHODS : Plasma levels of triglycerides, total cholesterol, and fractions of HTLV-1-infected individuals of both sexes with different clinical progressions were determined. RESULTS : Elevated levels of triglyceride and very low-density lipoproteins (VLDL were exclusively detected in HTLV-1-infected women from asymptomatic and HAM/TSP groups compared with uninfected individuals (p = 0.02. CONCLUSIONS : Elevated triglyceride and VLDL levels in HTLV-1-infected women may be related to the predominance of HAM/TSP in women.

  6. DNA rearrangement in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene

    International Nuclear Information System (INIS)

    Tsujimoto, Y.; Bashir, M.M.; Givol, I.; Cossman, J.; Jaffe, E.; Croce, C.M.

    1987-01-01

    In most human lymphomas, the chromosome translocation t(14;18) occurs within two breakpoint clustering regions on chromosome 18, the major one at the 3' untranslated region of the bcl-2 gene and the minor one at 3' of the gene. Analysis of a panel of follicular lymphoma DNAs using probes for the first exon of the bcl-2 gene indicates that DNA rearrangements may also occur 5' to the involved bcl-2 gene. In this case the IgH locus and the bcl-2 gene are found in an order suggesting that an inversion also occurred during the translocation process. The coding region of the bcl-2 gene, however, are left intact in all cases of follicular lymphoma studied to date

  7. First Identification of the Toxicity of Microcystins on Pancreatic Islet Function in Humans and the Involved Potential Biomarkers.

    Science.gov (United States)

    Zhao, Yanyan; Xue, Qingju; Su, Xiaomei; Xie, Liqiang; Yan, Yunjun; Wang, Lixiao; Steinman, Alan D

    2016-03-15

    Microcystins (MCs) produced by cyanobacteria have been recognized as a major public health threat. However, the toxicity of MCs to humans is still largely unknown. In this study, we examined the changes in pancreatic islet function in fishers exposed to ambient levels of MCs at Lake Taihu and, using a mouse model, explored the molecular mechanisms involved in toxicity. MCs content in the serum of fishers tested positive, with a range from 0.10 to 0.64 μg/L. Both lower blood insulin levels (2.26 ± 0.96 μIU/mL) and impaired fasting glucose were found in participants from the Meiliang Bay area in Lake Taihu, where MC-LR levels were substantially greater than the MC threshold established by WHO for drinking water. Animal experiments showed that glucose level increased by 27.9% in mice exposed to 5 μg/kg bw and decreased by 41.5% in mice exposed to 20 μg/kg bw. Blood insulin levels declined by 21.9% and 56.2% in mice exposed to 5 and 20 μg/kg bw MC-LR, respectively, which was consistent with the results observed in fishers. Furthermore, the diabetes gene pdx1 and several other proteins (such as Ppp3ca, Ide, Marcks, Pgk1, Suclg1, Ndufs4) involved in insulin secretion were identified for the first time in mice following MC-LR exposure; these biomarkers were considered responsible for MC-LR induced islet dysfunction. This study suggests that subchronic exposure to environmental levels of MCs may increase the risk of the occurrence of diabetes in humans.

  8. EINSTEIN EQUATIONS FOR TETRAD FIELDS ECUACIONES DE EINSTEIN PARA CAMPOS TETRADOS

    Directory of Open Access Journals (Sweden)

    Héctor Torres-Silva

    2008-11-01

    Full Text Available Every metric tensor can be expressed by the inner product of tetrad fields. We prove that Einstein's equations for these fields have the same form as the stress-energy tensor of electromagnetism if the total external current . Using the Evans' unified field theory, we show that the true unification of gravity and electromagnetism is with source-free Maxwell equations.Todo tensor métrico puede ser expresado por el producto interno de campos tetrados. Se prueba que las ecuaciones de Einstein para esos campos tienen la misma forma que el tensor electromagnético de momento-energía si la corriente externa total es igual a cero. Usando la teoría de campo unificado de Evans se muestra que la verdadera unificación de la gravedad y el electromagnetismo es con las ecuaciones de Maxwell sin fuentes.

  9. Spatial entanglement patterns and Einstein-Podolsky-Rosen steering in Bose-Einstein condensates

    Science.gov (United States)

    Fadel, Matteo; Zibold, Tilman; Décamps, Boris; Treutlein, Philipp

    2018-04-01

    Many-particle entanglement is a fundamental concept of quantum physics that still presents conceptual challenges. Although nonclassical states of atomic ensembles were used to enhance measurement precision in quantum metrology, the notion of entanglement in these systems was debated because the correlations among the indistinguishable atoms were witnessed by collective measurements only. Here, we use high-resolution imaging to directly measure the spin correlations between spatially separated parts of a spin-squeezed Bose-Einstein condensate. We observe entanglement that is strong enough for Einstein-Podolsky-Rosen steering: We can predict measurement outcomes for noncommuting observables in one spatial region on the basis of corresponding measurements in another region with an inferred uncertainty product below the Heisenberg uncertainty bound. This method could be exploited for entanglement-enhanced imaging of electromagnetic field distributions and quantum information tasks.

  10. Effective equivalence of the Einstein-Cartan and Einstein theories of gravity

    International Nuclear Information System (INIS)

    Nester, J.M.

    1977-01-01

    I prove that, for any choice of minimally coupled source field Lagrangian for the Einstein-Cartan-Sciama-Kibble theory of gravity, there exists a related minimally coupled source field Lagrangian for the Einstein theory which produces the same field equations for the metric and source field. By using a standard first-order form for source Lagrangians, the converse is also demonstrated. This establishes a one-to-one correspondence between source Lagrangians for the two theories which clearly reveals their similarities and their differences. Because of this ''equivalence,'' one can view either theory, in terms of the other, as minimal coupling for a related Minkowski source Lagrangian or as nonminimal coupling for the same Minkowski source Lagrangian. Consequently the two theories are, in this sense, indistinguishable. Some other implications of this ''equivalence'' are discussed

  11. Th9/IL-9 Profile in Human Echinococcosis: Their Involvement in Immune Response during Infection by Echinococcus granulosus

    Directory of Open Access Journals (Sweden)

    Nannan Pang

    2014-01-01

    Full Text Available Th9 cells have been reported to contribute to immune responses; however, the role of Th9 cells in Echinococcus granulosus infection is unknown. This study is to determine whether Th9 cells and IL-9 are involved in human Echinococcus granulosus infection. Compared with healthy controls (HC group, the mRNA levels of PU.1, IL-9, and GATA-3 were significantly increased in patients before therapy (CE group, as revealed by qRT-PCR. Flow cytometry analysis showed that the percentages of Th9 and Th2 cells in CE group were significantly higher. The levels of IL-9, IL-4, IL-10, and TGF-β in CE group were also significantly increased, as detected by CBA assay. The percentages of Th9 and Th2 cells in CE group were positively correlated. After treatments of surgery in combination with albendazole, the PU.1 and GATA-3 mRNA levels were significantly decreased in patients after therapy (PCE group compared with CE group. The numbers of Th9 and Th2 cells and levels of IL-9, IL-4, IL-10, and TGF-β were also significantly decreased in PCE group. In conclusion, the ratios of Th9 cells and IL-9 levels were significantly decreased after treatment, suggesting that Th9/IL-9 may be involved in immune response induced by Echinococcus granulosus infection.

  12. EMMPRIN expression is involved in the development of interstitial fibrosis and tubular atrophy in human kidney allografts.

    Science.gov (United States)

    Kemmner, Stephan; Schulte, Christian; von Weyhern, Claus Hann; Schmidt, Roland; Baumann, Marcus; Heemann, Uwe; Renders, Lutz; Schmaderer, Christoph

    2016-03-01

    Matrix metalloproteinases (MMP) are involved in the development of interstitial fibrosis and tubular atrophy (IF/TA) in renal disease. The synthesis of MMP is activated by the extracellular matrix metalloproteinases inducer protein (EMMPRIN). To analyze the role of EMMPRIN in IF/TA, we retrospectively detected EMMPRIN expression in specimens of human renal allografts with various levels of IF/TA. Immunohistochemistry was performed to detect EMMPRIN expression. In a retrospective analysis, a total cohort of 50 specimens were divided according to BANFF-classification into four subgroups (0-3): no, mild (≤ 25%), moderate (26-50%), or severe (>50%) IF/TA. Among other parameters, renal function was analyzed and compared to EMMPRIN expression. In 24 of 38 biopsies, we detected positive EMMPRIN staining. All nephrectomy (n = 12) samples were negative for EMMPRIN. Positive staining in the biopsy samples was detectable on the basolateral side of tubular epithelial cells. EMMPRIN staining was negatively correlated with IF/TA (p EMMPRIN expression in IF/TA groups 0 and 3 (p = 0.021) and groups 1 and 3 (p = 0.004). Furthermore, we found significant correlations between EMMPRIN staining and renal function. Our data suggest that EMMPRIN is involved in the pathophysiology of IF/TA. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  13. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

    Science.gov (United States)

    Kanno, Shin-ichiro; Kuzuoka, Hiroyuki; Sasao, Shigeru; Hong, Zehui; Lan, Li; Nakajima, Satoshi; Yasui, Akira

    2007-01-01

    DNA damage causes genome instability and cell death, but many of the cellular responses to DNA damage still remain elusive. We here report a human protein, PALF (PNK and APTX-like FHA protein), with an FHA (forkhead-associated) domain and novel zinc-finger-like CYR (cysteine–tyrosine–arginine) motifs that are involved in responses to DNA damage. We found that the CYR motif is widely distributed among DNA repair proteins of higher eukaryotes, and that PALF, as well as a Drosophila protein with tandem CYR motifs, has endo- and exonuclease activities against abasic site and other types of base damage. PALF accumulates rapidly at single-strand breaks in a poly(ADP-ribose) polymerase 1 (PARP1)-dependent manner in human cells. Indeed, PALF interacts directly with PARP1 and is required for its activation and for cellular resistance to methyl-methane sulfonate. PALF also interacts directly with KU86, LIGASEIV and phosphorylated XRCC4 proteins and possesses endo/exonuclease activity at protruding DNA ends. Various treatments that produce double-strand breaks induce formation of PALF foci, which fully coincide with γH2AX foci. Thus, PALF and the CYR motif may play important roles in DNA repair of higher eukaryotes. PMID:17396150

  14. Undergraduate research involving human subjects should not be granted ethical approval unless it is likely to be of publishable quality.

    Science.gov (United States)

    Gallagher, Cathal T; McDonald, Lisa J; McCormack, Niamh P

    2014-06-01

    Small-scale research projects involving human subjects have been identified as being effective in developing critical appraisal skills in undergraduate students. In deciding whether to grant ethical approval to such projects, university research ethics committees must weigh the benefits of the research against the risk of harm or discomfort to the participants. As the learning objectives associated with student research can be met without the need for human subjects, the benefit associated with training new healthcare professionals cannot, in itself, justify such risks. The outputs of research must be shared with the wider scientific community if it is to influence future practice. Our survey of 19 UK universities indicates that undergraduate dissertations associated with the disciplines of medicine, dentistry and pharmacy are not routinely retained in their library catalogues, thus closing a major avenue to the dissemination of their findings. If such research is unlikely to be published in a peer-reviewed journal, presented at a conference, or otherwise made available to other researchers, then the risks of harm, discomfort or inconvenience to participants are unlikely to be offset by societal benefits. Ethics committees should be satisfied that undergraduate research will be funnelled into further research that is likely to inform clinical practice before granting ethical approval.

  15. H{sup +}/peptide transporter (PEPT2) is expressed in human epidermal keratinocytes and is involved in skin oligopeptide transport

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, Michiko; Katayoshi, Takeshi; Kobayashi-Nakamura, Kumiko [DHC Corporation Laboratories, Division 2, 2-42 Hamada, Mihama-ku, Chiba 261-0025 (Japan); Akagawa, Mitsugu [Department of Biological Chemistry, Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai 599-8531 (Japan); Tsuji-Naito, Kentaro, E-mail: knaito@dhc.co.jp [DHC Corporation Laboratories, Division 2, 2-42 Hamada, Mihama-ku, Chiba 261-0025 (Japan)

    2016-07-08

    Peptide transporter 2 (PEPT2) is a member of the proton-coupled oligopeptide transporter family, which mediates the cellular uptake of oligopeptides and peptide-like drugs. Although PEPT2 is expressed in many tissues, its expression in epidermal keratinocytes remains unclear. We investigated PEPT2 expression profile and functional activity in keratinocytes. We confirmed PEPT2 mRNA expression in three keratinocyte lines (normal human epidermal keratinocytes (NHEKs), immortalized keratinocytes, and malignant keratinocytes) by reverse transcription-polymerase chain reaction (RT-PCR) and quantitative real-time RT-PCR. In contrast to PEPT1, PEPT2 expression in the three keratinocytes was similar or higher than that in HepG2 cells, used as PEPT2-positive cells. Immunolocalization analysis using human skin showed epidermal PEPT2 localization. We studied keratinocyte transport function by measuring the oligopeptide content using liquid chromatography/tandem mass spectrometry. Glycylsarcosine uptake in NHEKs was pH-dependent, suggesting that keratinocytes could absorb small peptides in the presence of an inward H{sup +} gradient. We also performed a skin-permeability test of several oligopeptides using skin substitute, suggesting that di- and tripeptides pass actively through the epidermis. In conclusion, PEPT2 is expressed in keratinocytes and involved in skin oligopeptide uptake. -- Highlights: •PEPT2 is expressed in keratinocytes, which are more common than other skin cells. •Immunolocalization analysis using human skin revealed epidermal PEPT2 localization. •Keratinocytes could absorb small peptides in the presence of an inward H{sup +} gradient. •Di- and tripeptide pass actively through the epidermis.

  16. Bose-Einstein condensation and applications

    International Nuclear Information System (INIS)

    Jaksch, D.H.

    1999-10-01

    After a short introduction on recent developments in the field of Bose-Einstein condensation (BEC) with weakly interacting neutral atoms in the first part of my thesis I investigate the properties of a BEC in its stationary state with the help of quantum kinetic theory in the second part. Especially, I consider the particle number and phase fluctuations of a BEC emerging from the interaction of the condensed particles with the thermal cloud of atoms. In the third part of my thesis I show how one might realize the Bose-Hubbard model in optical lattices by making use of BEC. In the last part of my work I show how one can realize quantum logic with neutral atoms trapped in either optical lattices or in magnetic microtraps. (author)

  17. Faraday waves in Bose-Einstein condensates

    International Nuclear Information System (INIS)

    Nicolin, Alexandru I.; Carretero-Gonzalez, R.; Kevrekidis, P. G.

    2007-01-01

    Motivated by recent experiments on Faraday waves in Bose-Einstein condensates we investigate both analytically and numerically the dynamics of cigar-shaped Bose-condensed gases subject to periodic modulation of the strength of the transverse confinement. We offer a fully analytical explanation of the observed parametric resonance, based on a Mathieu-type analysis of the non-polynomial Schroedinger equation. The theoretical prediction for the pattern periodicity versus the driving frequency is directly compared to the experimental data, yielding good qualitative and quantitative agreement between the two. These results are corroborated by direct numerical simulations of both the one-dimensional non-polynomial Schroedinger equation and of the fully three-dimensional Gross-Pitaevskii equation

  18. Revealing Hidden Einstein-Podolsky-Rosen Nonlocality

    Science.gov (United States)

    Walborn, S. P.; Salles, A.; Gomes, R. M.; Toscano, F.; Souto Ribeiro, P. H.

    2011-04-01

    Steering is a form of quantum nonlocality that is intimately related to the famous Einstein-Podolsky-Rosen (EPR) paradox that ignited the ongoing discussion of quantum correlations. Within the hierarchy of nonlocal correlations appearing in nature, EPR steering occupies an intermediate position between Bell nonlocality and entanglement. In continuous variable systems, EPR steering correlations have been observed by violation of Reid’s EPR inequality, which is based on inferred variances of complementary observables. Here we propose and experimentally test a new criterion based on entropy functions, and show that it is more powerful than the variance inequality for identifying EPR steering. Using the entropic criterion our experimental results show EPR steering, while the variance criterion does not. Our results open up the possibility of observing this type of nonlocality in a wider variety of quantum states.

  19. Energy in the Einstein-aether theory

    International Nuclear Information System (INIS)

    Eling, Christopher

    2006-01-01

    We investigate the energy of a theory with a unit vector field (the aether) coupled to gravity. Both the Weinberg and Einstein type energy-momentum pseudotensors are employed. In the linearized theory we find expressions for the energy density of the 5 wave modes. The requirement that the modes have positive energy is then used to constrain the theory. In the fully nonlinear theory we compute the total energy of an asymptotically flat spacetime. The resulting energy expression is modified by the presence of the aether due to the nonzero value of the unit vector at infinity and its 1/r falloff. The question of nonlinear energy positivity is also discussed, but not resolved

  20. Twistor theory and the Einstein equations

    International Nuclear Information System (INIS)

    Law, P.R.

    1985-01-01

    R. Penrose has argued that the goal of twistor theory with regard to the vacuum Einstein equations ought to consist of some kind of unification of twistor-theoretic description of anti-self-dual (a.s.d.) and self-dual (s.d.) space-times. S.d. space-times currently possess a description only in terms of dual twistor space, however, rather than twistor space. In this paper, suggestions due to Penrose for providing a purely twistor space description of s.d. space-times are investigated. It is shown how the points of certain s.d. space-times define mappings on twistor space and the geometry of these mappings is studied. The families of mappings for two particular s.d. space-times are presented explicitly. (author)