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Sample records for efter peroral kontraception

  1. Efter strejkerne -

    DEFF Research Database (Denmark)

    Stamhus, Jørgen; Scheuer, Steen; Christensen, Susanne

    Kan strejker betale sig? Dette klassiske spørgsmål blev rejst fra flere sider efter arbejdskonflikterne i forbindelse med overenskomstfornyelserne i den offentlige sektor foråret 2008. Spørgsmålet blev i pressen overvejende besvaret i generelle vendinger, med et bastant nej, og uden en nærmere vu...

  2. Efter Solingen

    DEFF Research Database (Denmark)

    Peters, Rikke Alberg

    2013-01-01

    Den 29. maj 1993 blev Tyskland rystet af en brutal mordbrand, der i den grad kom til at præge den offentlige debat om demokratiets vilkår efter murens fald. Stedet hvor attentatet foregik, var Solingen, en by med godt 160.000 indbyggere i den vestlige del af Tyskland. I brandattentatet omkom fem ...

  3. Current Status of Peroral Endoscopic Myotomy

    Science.gov (United States)

    Cho, Young Kwan; Kim, Seong Hwan

    2018-01-01

    Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders. PMID:29397656

  4. Current Status of Peroral Endoscopic Myotomy.

    Science.gov (United States)

    Cho, Young Kwan; Kim, Seong Hwan

    2018-01-01

    Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders.

  5. Current Status of Peroral Endoscopic Myotomy

    Directory of Open Access Journals (Sweden)

    Young Kwan Cho

    2018-01-01

    Full Text Available Peroral endoscopic myotomy (POEM has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus. Contraindications include prior radiation therapy to the esophagus and prior extensive esophageal mucosal resection/ablation involving the POEM field. Most of the complications are minor and self-limited and can be managed conservatively. As POEM emerged as the main treatment for achalasia, various adaptations to tunnel endoscopic surgery have been attempted. Tunnel endoscopic surgery includes POEM, peroral endoscopic tumor resection, gastric peroral endoscopic pyloromyotomy. POEM has been widely accepted as a treatment for all types of achalasia, even for specific cases such as achalasia with failed prior treatments, and hypertensive motor disorders.

  6. På jagt efter klasse

    DEFF Research Database (Denmark)

    Faber, Stine Thidemann

    I afhandlingen På jagt efter klasse undersøger Stine Thidemann Faber, hvordan klasse manifesterer sig i kvinders fortællinger om hverdagsliv, og hvordan klasserelaterede forskelle opleves og kommer til udtryk sammen med andre differentieringsformer, først og fremmest køn. Baggrunden for afhandlin...

  7. Nato efter Trump: Posen skal rystes

    DEFF Research Database (Denmark)

    Rynning, Sten; Ringsmose, Jens

    2017-01-01

    Efter valget af Donald Trump bør Danmark komme ind i kampen og involvere sig i Det Europæiske Forsvarsagentur EDA og søge dybere bilateral kontakt til Tyskland og Frankrig, som kommer til at være bannerførere på forsvarsområdet. Det skriver Sten Rynning og Jens Ringsmose i denne analyse.......Efter valget af Donald Trump bør Danmark komme ind i kampen og involvere sig i Det Europæiske Forsvarsagentur EDA og søge dybere bilateral kontakt til Tyskland og Frankrig, som kommer til at være bannerførere på forsvarsområdet. Det skriver Sten Rynning og Jens Ringsmose i denne analyse....

  8. Efter strejkerne

    DEFF Research Database (Denmark)

    Stamhus, Jørgen; Scheuer, Steen; Christensen, Ellen Susanne

    2009-01-01

    Kan strejker betale sig? Dette klassiske spørgsmål blev rejst fra flere sider efter arbejdskonflikterne i forbindelse med overenskomstfornyelserne i den offentlige sektor foråret 2008. Spørgsmålet blev i pressen overvejende besvaret i generelle vendinger, med et bastant nej, og uden en nærmere vu...

  9. Per-oral cholangioscopy

    OpenAIRE

    Monga, Amitabh; Ramchandani, Mohan; Reddy, D Nageshwar

    2011-01-01

    Direct endoscopic views of bile duct have been described in literature since the 1970s. Since then rapid strides have been made with the advent of technologically advanced systems with better image quality and maneuverability. The single operator semi-disposable per-oral cholangioscope and other novel methods such as the cholangioscopy access balloon are likely to revolutionize this field. Even though cholangioscopy is currently used primarily for characterization of indeterminate strictures ...

  10. 4 år efter grundskolen

    DEFF Research Database (Denmark)

    Andersen, Dines

    begynde at kaste nyt lys over hvorfor-spørgsmålene. Denne rapport beskæftiger sig med unge 4 år efter grundskolen. Hvor langt er de kommet i deres uddannelsesforløb? Og hvordan kan vi forklare deres placering på dette tidspunkt? Nogle er tilsyneladende ingen veje kommet. De tilhører den uddannelsesmæssige...

  11. Tension pneumothorax during peroral endoscopic myotomy for treatment of esophageal achalasia under general anesthesia

    Directory of Open Access Journals (Sweden)

    Tsung-Shih Li

    Full Text Available Abstract More and more endoscopically gastrointestinal procedures require anesthesiologists to perform general anesthesia, such as "peroral endoscopic myotomy". Peroral endoscopic myotomy is a novel invasive treatment for the primary motility disorder of esophagus, called esophageal achalasia. Despite of its minimally invasive feature, there are still complications during the procedure which develop to critical conditions and threat patients’ lives. Herein we describe a case about tension pneumothorax subsequent to esophageal rupture during peroral endoscopic myotomy. The emergent management of the complication is stated in detail. The pivotal points of general anesthesia for patients undergoing peroral endoscopic myotomy are emphasized and discussed. Also, intraoperative and post-operative complications mentioned by literature are integrated.

  12. Forældres oplevelse af genindlæggelse af deres nyfødte barn efter ambulant fødsel

    DEFF Research Database (Denmark)

    Feenstra, Maria Monberg; Nilsson, Ingrid; Danbjørg, Dorthe Boe

    . telefon i døgnets 24 timer. Derudover kommer familien til ambulant opfølgning på sygehuset 48-72 timer efter fødslen. Til trods for den tætte kontakt til sundhedspersonalet, oplever stadig flere familier at blive genindlagt kort tid efter udskrivelsen grundet komplikationer vedrørende deres nyfødte barns...... fødslen og hvis nyfødte barn blev genindlagt på grund af manglende trivsel, blev inviteret til at deltage i undersøgelsen. Forældre, der ikke talte dansk, norsk eller svensk blev ekskluderet. Familierne blev interviewet via telefon efter de havde haft 1. sundhedsplejerskebesøg efter genindlæggelsen. Mødre...

  13. Hel igen efter amputation - og vejen dertil

    DEFF Research Database (Denmark)

    Østergaard, Elisabeth Bomholt

    Hel igen efter amputation – og vejen dertil Elisabeth Bomholt Østergaard, PT, Master i sundhedsantropologi, Dip.pæd. Baggrund Sundhedsprofessionelle bør udvikle større opmærksomhed på og forståelse for, hvilke måder mennesker oplever ’inkorporation’ af diverse proteser, som fx pacemaker, benprotese.......000 og 300.000 mennesker type 2- diabetes og forekomsten er kraftigt stigende og forekommer i stadig yngre aldersgrupper (Dansk Sygeplejeråd 2006) med amputation som mulig konsekvens. Formål Opnå indsigt i hvad der kan medvirke til, at mennesker kan føle sig hele igen efter en benamputation, føle sig...... kropsbevidsthed/at mærke kroppen – at få fokus væk fra kroppen igen, så kroppen atter kan blive fraværende, så der frigives plads til at kunne rette opmærksomheden andre steder hen: meget tidligt at oplyse om muligheden for og helst opfordre til at få besøg af en person, der selv har oplevet amputation på egen...

  14. Submucosal tunnel endoscopy: Peroral endoscopic myotomy and peroral endoscopic tumor resection

    Science.gov (United States)

    Eleftheriadis, Nikolas; Inoue, Haruhiro; Ikeda, Haruo; Onimaru, Manabu; Maselli, Roberta; Santi, Grace

    2016-01-01

    Peroral endoscopic myotomy (POEM) is an innovative, minimally invasive, endoscopic treatment for esophageal achalasia and other esophageal motility disorders, emerged from the natural orifice transluminal endoscopic surgery procedures, and since the first human case performed by Inoue in 2008, showed exciting results in international level, with more than 4000 cases globally up to now. POEM showed superior characteristics than the standard 100-year-old surgical or laparoscopic Heller myotomy (LHM), not only for all types of esophageal achalasia [classical (I), vigorous (II), spastic (III), Chicago Classification], but also for advanced sigmoid type achalasia (S1 and S2), failed LHM, or other esophageal motility disorders (diffuse esophageal spasm, nutcracker esophagus or Jackhammer esophagus). POEM starts with a mucosal incision, followed by submucosal tunnel creation crossing the esophagogastric junction (EGJ) and myotomy. Finally the mucosal entry is closed with endoscopic clip placement. POEM permitted relatively free choice of myotomy length and localization. Although it is technically demanding procedure, POEM can be performed safely and achieves very good control of dysphagia and chest pain. Gastroesophageal reflux is the most common troublesome side effect, and is well controllable with proton pump inhibitors. Furthermore, POEM opened the era of submucosal tunnel endoscopy, with many other applications. Based on the same principles with POEM, in combination with new technological developments, such as endoscopic suturing, peroral endoscopic tumor resection (POET), is safely and effectively applied for challenging submucosal esophageal, EGJ and gastric cardia tumors (submucosal tumors), emerged from muscularis propria. POET showed up to know promising results, however, it is restricted to specialized centers. The present article reviews the recent data of POEM and POET and discussed controversial issues that need further study and future perspectives. PMID

  15. Russisk Politik i Arktis efter Ukrainekrisen

    DEFF Research Database (Denmark)

    Kristensen, Kristian Søby; Sakstrup, Casper

    Arktis. Udviklingen af Ruslands politik i Arktis er således af afgørende betydning for rigsfællesskabet og betingelserne for dansk udenrigs- og sikkerhedspolitik. Rapporten undersøger derfor udviklingen i russisk politik i Arktis på to dimensioner – diplomati og militær – før og efter Ukrainekrisen...... diplomati fortsat kan medvirke til at fastholde Arktis som et stabilt geopolitisk område præget af relativt lav spænding....

  16. Current Status of Peroral Endoscopic Myotomy

    OpenAIRE

    Cho, Young Kwan; Kim, Seong Hwan

    2018-01-01

    Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic ...

  17. Hel igen efter amputation

    DEFF Research Database (Denmark)

    Østergaard, Elisabeth Bomholt

    2007-01-01

    aldersgrupper (Dansk Sygeplejeråd 2006) med amputation som mulig konsekvens. Formål Opnå indsigt i • hvad der kan medvirke til, at mennesker kan føle sig hele igen efter en benamputation, føle sig reintegreret i samfundet og opnå et tilfreds-stillende hverdagsliv • kropsforandringers indflydelse på identiteten...... frigives plads til at kunne rette opmærksomheden andre steder hen; meget tidligt at oplyse om muligheden for og helst opfordre til at få besøg af en person, der selv har oplevet amputation på egen krop; tilrettelægge tilbud til grupper, så der skabes mulighed for at møde andre i ’samme’ situation; tage...

  18. Index viktat efter omsättning : Presterar ett index viktat efter omsättning bättre än ett index viktat efter börsvärde?

    OpenAIRE

    Walljaeger, Christoffer; Uhrdin, Susanna

    2005-01-01

    Om den effektiva marknadshypotesen inte gäller skulle varje aktie handlas över eller under aktiens verkliga värde. Om så är fallet skulle alla index som är viktade efter börsvärde automatiskt överexponeras när en aktie handlas över dess verkliga värde och underexponera när en aktie handlas under dess verkliga värde. Det här betyder att kapitalviktade index är fundamentalt och strukturellt bristfälliga och kommer kontinuerligt övervikta alla aktier som handlas över verkligt värde och undervikt...

  19. Tænk ikke, men se efter! - Wittgensteins brug af eksemplet

    DEFF Research Database (Denmark)

    Krause-Jensen, Niels Henrik

    2016-01-01

    I dette kapitel er ærindet at præsentere en filosofisk metode, som på en langt mere gennemgribende måde end vanligt orienterer sig efter eksempler. Udgangspunktet er sprogfilosoffen Ludwig Wittgensteins tænkning, hvor det vises, at der er noget ganske særligt på spil: Eksempler bruges ikke til...

  20. Peroral cholangioscopy with intracorporeal electrohydraulic lithotripsy for choledocholithiasis.

    Science.gov (United States)

    Hixson, L J; Fennerty, M B; Jaffee, P E; Pulju, J H; Palley, S L

    1992-03-01

    Five patients with choledocholithiasis refractory to standard extraction methods after endoscopic sphincterotomy underwent peroral cholangioscopy with the "mother-daughter" endoscopy system. electrohydraulic lithotripsy of nine stones was performed successfully and without complication, other than minor transient bleeding in one patient. The outer sheath of the "daughter scope" sustained a linear burn in one instance. This method of stone fragmentation is a useful adjunct to achieve ductal clearance in difficult cases.

  1. Short-term parenteral and peroral testosterone administration in men with alcoholic cirrhosis

    DEFF Research Database (Denmark)

    Gluud, C; Bennett, Patrick; Dietrichson, O

    1981-01-01

    other day, rather constant serum concentrations with median values of about 30 ng/ml were reached after 4 days. Peroral testosterone administration (800 mg micronized free testosterone) each day also resulted in fairly constant serum concentrations after 4 days, and the median values were about 50 ng......Serum concentrations of testosterone were measured in 24 male patients with alcoholic cirrhosis during testosterone administration. The purpose was to compare serum concentrations of testosterone during peroral with those during parenteral testosterone administration in these patients. Patients who...... were injected intramuscularly with a combination of short- and long-acting testosterone (Triolandren, 348 mg testosterone) had median peak values of serum testosterone of about 40 ng/ml, which fell to basal levels after a fortnight. During testosterone propionate injections (84 mg testosterone) every...

  2. Peroral Endoscopic Myotomy Versus Heller Myotomy for Achalasia: Pros and Cons.

    Science.gov (United States)

    Tefas, Cristian; Ababneh, Rami; Tanţău, Marcel

    2018-01-01

    Achalasia is an esophageal motor disorder that has multiple endoscopic and surgical methods of treatment. However, there is no consensus on optimal therapy in patients suffering from this disorder. This review discusses two therapies with similar but technically different concepts, peroral endoscopic myotomy and Heller surgical myotomy. After a brief introduction to the basic problems of achalasia, technical considerations, intra and postprocedural complications are presented and the advantages and disadvantages of the two procedures are discussed, based on the relevant articles in the literature. Heller surgical myotomy and peroral endoscopic myotomy appear to be similar in performance with similar results in terms of gastroesophageal reflux rates. However, with experience being gained in the field of endoscopic myotomy, this procedure seems more advantageous, with similar success rates to those of the established surgical technique, but offering shorter operating times, shorter hospitalizations and, ultimately, lower costs. Celsius.

  3. Use of guiding sheaths in peroral fluoroscopic gastroduodenal stent placement

    International Nuclear Information System (INIS)

    Bae, Jae-Ik; Shin, Ji Hoon; Song, Ho-Young; Yoon, Chang Jin; Nam, Deok Ho; Choi, Won-Chan; Lim, Jin-Oh

    2005-01-01

    Our purpose was to assess the safety and usefulness of guiding sheaths in peroral fluoroscopic gastroduodenal stent placement. Two types of guiding sheath were made from straight polytetrafluoroethylene tubes. Type A was 80 cm in length, 4 mm in outer diameter and 3 mm in inner diameter. Type B was 70 cm in length, 6 mm in outer diameter and 5 mm in inner diameter. The type A sheath was used in 18 patients in whom a catheter-guide wire combination failed to pass through a stricture. The type B sheath was used in 22 patients in whom a stent delivery system failed to pass through the stricture due to loop formation within the gastric lumen. The overall success rate for guiding a catheter-guide wire through a stricture after using the type A sheath was 89%. The overall success rate for passing a stent delivery system through a stricture after using the type B sheath was 100%. All procedures were tolerated by the patients without any significant complications. The guiding sheaths were safe and useful in peroral fluoroscopic gastroduodenal stent placement. (orig.)

  4. Management of recurrent symptoms after per-oral endoscopic myotomy in achalasia

    NARCIS (Netherlands)

    van Hoeij, Froukje B.; Ponds, Fraukje A.; Werner, Yuki; Sternbach, Joel M.; Fockens, Paul; Bastiaansen, Barbara A.; Smout, André J. P. M.; Pandolfino, John E.; Rösch, Thomas; Bredenoord, Albert J.

    2018-01-01

    Background and Aims: Per-oral endoscopic myotomy (POEM) has been rapidly gaining ground as a treatment for achalasia. Although POEM is a safe and effective treatment, a subset of patients has persistent or recurrent symptoms after POEM. This study aimed to examine the efficacy of different

  5. Effect of peroral endoscopic myotomy on esophagogastric junction physiology in patients with achalasia

    NARCIS (Netherlands)

    Verlaan, Tessa; Rohof, Wout O.; Bredenoord, Albert J.; Eberl, Susanne; Rösch, Thomas; Fockens, Paul

    2013-01-01

    Pneumatic dilation and laparoscopic Heller myotomy improve parameters of esophageal function such as lower esophageal sphincter (LES) pressure, esophageal emptying, and esophagogastric junction (EGJ) distensibility. To evaluate the effect of peroral endoscopic myotomy (POEM) on esophagogastric

  6. Per-oral Endoscopic Myotomy (POEM): A safe and effective treatment for achalasia in geriatric

    Science.gov (United States)

    Hernández-Mondragón, Oscar Víctor; Solórzano-Pineda, Omar Michel; Blancas-Valencia, Juan Manuel; González-Martínez, Marina Alejandra

    2017-01-01

    Esophageal achalasia is a primary motor disorder of the esophagus characterized by impair relaxation of the lower esophageal sphincter and absent of esophageal peristalsis. Per-oral endoscopic myotomy is an alternative treatment to surgical Heller myotomy in patients over 65 years old. The aim of this paper was to describe the results of peroral endoscopic myotomy (POEM) or the treatment of achalasia in geriatric patients. We included patients over 65 years old with POEM, from retrospective cohort review, in which POEM was performed with a standardized technique in our department. 12 patients were included, the procedure was successful in 98% of patients, minor adverse events occurred without mortality. POEM is a safe and effective technique for the treatment of achalasia, the results of the study are similar to those reported in The literature.

  7. Peroral endoscopic myotomy

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Peroral endoscopic myotomy (POEM) incorporatesconcepts of natural orifice translumenal endoscopicsurgery and achieves endoscopic myotomy by utilizinga submucosal tunnel as an operating space.Although intended for the palliation of symptoms ofachalasia, there is mounting data to suggest it is alsoefficacious in the management of spastic esophagealdisorders. The technique requires an understanding ofthe pathophysiology of esophageal motility disorders aswell as knowledge of surgical anatomy of the foregut.POEM achieves short term response in 82% to 100% ofpatients with minimal risk of adverse events. In addition,it appears to be effective and safe even at the extremesof age and regardless of prior therapy undertaken.Although infrequent, the ability of the endoscopist tomanage an intraprocedural adverse event is critical asfailure to do so could result in significant morbidity. Themajor late adverse event is gastroesophageal refluxwhich appears to occur in 20% to 46% of patients.Research is being conducted to clarify the optimaltechnique for POEM and a personalized approach bymeasuring intraprocedural esophagogastric junctiondistensibility appears promising. In addition toesophageal disorders,POEM is being studied in themanagement of gastroparesis (gastric pyloromyotomy)with initial reports demonstrating technical feasibility.Although POEM represents a paradigm shift themanagement of esophageal motility disorders, theresults of prospective randomized controlled trials withlong-term follow up are eagerly awaited.

  8. Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study

    NARCIS (Netherlands)

    von Renteln, Daniel; Fuchs, Karl-Hermann; Fockens, Paul; Bauerfeind, Peter; Vassiliou, Melina C.; Werner, Yuki B.; Fried, Gerald; Breithaupt, Wolfram; Heinrich, Henriette; Bredenoord, Albert J.; Kersten, Jan F.; Verlaan, Tessa; Trevisonno, Michael; Rösch, Thomas

    2013-01-01

    Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months

  9. The effects of peroral glycerol on plasma osmolarity in diabetic patients and healthy individuals

    DEFF Research Database (Denmark)

    Thornit, Dorte Nellemann; Sander, Birgit; la Cour, Morten

    2009-01-01

    Glycerol is used as a peroral treatment of increased intraocular and intracranial pressure due to its osmotic effect despite the potential increase in blood pressure and blood glucose. We examined the effects of peroral glycerol in diabetic patients and healthy individuals on blood pressure......, capillary glucose, and plasma osmolarity. On two separate days, 15 diabetic patients ingested glycerol in doses of 855 and 1710 mg/kg body weight in a randomised, unmasked sequence. Five healthy individuals ingested a dose of 1710 mg/kg body weight. Mean arterial blood pressure (MAP), capillary glucose (CG......, non-significant increase occurred in blood pressure. Maximal DeltaCG was approximately 1 mM irrespective of the dose and presence of diabetes (p > 0.1). The pOSM response was analysed with a kinetic model and found independent of the presence of diabetes (p = 0.6). The maximal fitted DeltapOSM was 12...

  10. Dopamine transporter SPECT imaging of the peroral addicts of compound codeine phosphate solution

    International Nuclear Information System (INIS)

    Sun Taotao; Hu Shu; Jia Shaowei; Chen Qing; Fan Rong

    2010-01-01

    Objective: To study the damage to striatum in patients perorally addicted to compound codeine phosphate solution by using the brain dopamine transporter SPECT imaging. Methods: Patients perorally addicted to compound codeine phosphate solution (n = 29) and addicted to heroin (n = 27), as well as healthy volunteers (n = 31) were included in the study. Each of them underwent dopamine transporter (DAT) SPECT imaging with 99 Tc m -2β-[N, N'-bis-( 2- mercaptoethyl ) ethylenediamino] methyl, 3β-(4-chlorophenyl)tropane ( 99 Tc m -TRODAT-1). The striatum volume (V, cm 3 ), mass (m, g) and radioactivity ratio (Ra) of striatum to whole brain were calculated using physio-mathematical modeling method. Results: Bilateral striatum of healthy volunteers showed typical 'panda eyes' pattern and the distribution of DAT was uniform and symmetrical. Bilateral striatum of patients addicted to compound codeine phosphate showed impaired tracer uptake, similar to those addicted to heroin. The V, m and Ra of bilateral striatum of patients addicted to compound codeine phosphate were (23.68±4.94) cm 3 , (24.87±5.19) g and (5.01±0.88) %, respectively, which were significantly lower than those of healthy controls: (35.39 ±4.42) cm 3 ,(37.16±4.64) g and (7.93±0.86)% (t =-9.69, -9.69, - 13.01, all P =0.000), but significantly higher than those addicted to heroin: (18.87±4.66) cm 3 , (19.81±4.90) g and (4.26±1.02) % (t =3.74, 3.74, 2.96, P = 0.000, 0.000, 0.005). Conclusion: Long-term peroral intake of compound codeine phosphate solution may damage the function of cerebral striatum, which is someway similar to though less severe than, the impairment caused by heroin. (authors)

  11. Peroral endoscopic myotomy for the treatment of achalasia in a patient with esophageal varices. A case report.

    Science.gov (United States)

    Shen, Naning; Wang, Xin; Zhang, Xiaoyin; Yao, Liping; Xie, Huahong; Zhang, Hongbo

    2017-06-01

    Achalasia is very uncommon, and rarely does achalasia co-exist with esophageal varices. We present a 62-year-old woman who was diagnosed with both achalasia and esophageal varices in December 2014 and had a past history of hematemesis. The patient's achalasia symptoms' Eckardt score was 9, and her hepatic function was Child-Pugh grade A6. After comprehensive assessment of the patient's health and discussion of the pros and cons of various therapies for achalasia, the patient underwent a peroral endoscopic myotomy. She was symptom-free after the operation and had no recurrence of achalasia symptoms at 20-month follow-up. No adverse events were reported. Peroral endoscopic myotomy for achalasia with esophageal varices has not been previously reported in the English literature.

  12. Single-Operator Peroral Cholangioscopy for Extraction of Cystic Duct Stones in Postcholecystectomy Mirizzi Syndrome

    Directory of Open Access Journals (Sweden)

    Jason Deforest Jones

    2017-01-01

    Full Text Available Mirizzi syndrome is an exceptionally rare diagnosis with an annual incidence of less than 1% in developed countries. In this disease process, stone burden in the cystic duct or gallbladder neck leads to common hepatic duct obstruction, either by mechanical compression or secondary inflammation. Mirizzi syndrome is classified into one of four types based on the presence and severity of cholecystobiliary fistulization. Treatment is primarily surgical in nature and largely dictated by the type of Mirizzi syndrome encountered. It is typically diagnosed in the preoperative or operative setting of cholecystectomy; however, there have been rare occurrences of postcholecystectomy diagnosis. Factors thought to predispose to postcholecystectomy disease include low insertion of the cystic duct and long remnant duct length. Few case reports exist describing this phenomenon and its management, which is made exceptionally difficult due to the presence of inflammation and surgical adhesion. We present the case of a young female with postcholecystectomy Mirizzi syndrome who underwent successful endoscopic management using peroral cholangioscopy and electrohydraulic lithotripsy. We also provide a brief overview of both Mirizzi syndrome and peroral cholangioscopy.

  13. Single-Operator Peroral Cholangioscopy for Extraction of Cystic Duct Stones in Postcholecystectomy Mirizzi Syndrome.

    Science.gov (United States)

    Jones, Jason Deforest; Pawa, Rishi

    2017-01-01

    Mirizzi syndrome is an exceptionally rare diagnosis with an annual incidence of less than 1% in developed countries. In this disease process, stone burden in the cystic duct or gallbladder neck leads to common hepatic duct obstruction, either by mechanical compression or secondary inflammation. Mirizzi syndrome is classified into one of four types based on the presence and severity of cholecystobiliary fistulization. Treatment is primarily surgical in nature and largely dictated by the type of Mirizzi syndrome encountered. It is typically diagnosed in the preoperative or operative setting of cholecystectomy; however, there have been rare occurrences of postcholecystectomy diagnosis. Factors thought to predispose to postcholecystectomy disease include low insertion of the cystic duct and long remnant duct length. Few case reports exist describing this phenomenon and its management, which is made exceptionally difficult due to the presence of inflammation and surgical adhesion. We present the case of a young female with postcholecystectomy Mirizzi syndrome who underwent successful endoscopic management using peroral cholangioscopy and electrohydraulic lithotripsy. We also provide a brief overview of both Mirizzi syndrome and peroral cholangioscopy.

  14. Per-oral endoscopic myotomy (POEM) for esophageal achalasia.

    Science.gov (United States)

    Pescarus, Radu; Shlomovitz, Eran; Swanstrom, Lee L

    2014-01-01

    Per-oral endoscopic myotomy (POEM) is a new minimally invasive endoscopic treatment for achalasia. Since the first modern human cases were published in 2008, around 2,000 cases have been performed worldwide. This technique requires advanced endoscopic skills and a learning curve of at least 20 cases. POEM is highly successful with over 90 % improvement in dysphagia while offering patients the advantage of a low impact endoscopic access. The main long-term complication is gastroesophageal reflux (GER) with an estimated incidence of 35 %, similar to the incidence of GER post-laparoscopic Heller with fundoplication. Although POEM represents a paradigm shift in the treatment of achalasia, more long-term data are clearly needed to further define its role in the treatment algorithm of this rare disease.

  15. Diagnostic and therapeutic peroral cholangioscopy

    Directory of Open Access Journals (Sweden)

    Jong Ho Moon

    2012-01-01

    Full Text Available Peroral cholangioscopy (POC provides direct visualization of the bile duct and facilitates diagnostic or therapeutic intervention. The currently available single-operator POC systems are "Mother-baby" scope system, SpyGlass direct visualization system, and direct POC using a regular ultra-slim upper endoscope. Direct POC using an ultra-slim upper endoscope having a larger 2-mm working channel can provide a valuable and economic solution for evaluating bile-duct lesions. Main diagnostic procedures under direct POC are visual characterization and optically guided target biopsy for the indeterminate bile duct lesion. Image-enhanced endoscopy such as narrow-band imaging has shown promise for more detailed evaluation of mucosal abnormality and can be performed under direct POC. Intracorporeal lithotripsy such as electrohydraulic lithotripsy or laser lithotripsy is a main therapeutic intervention of direct POC for patients with bile duct stones that are resistant to conventional endoscopic stone-removal procedures. Besides, tumor ablation therapy, such as photodynamic therapy and argon plasma coagulation may be also performed using direct POC. Further developments of the endoscope and specialized accessories or devices are expected to facilitate diagnostic and therapeutic role of this cholangioscopic procedure.

  16. Yummy Mummy – et forskningsprojekt om konstruktioner af kropsidentitet efter en fødsel

    DEFF Research Database (Denmark)

    Prinds, Christina Lange; Folmann, Birgitte; Nikolajsen, Helene

    2015-01-01

    “... those extra pounds make you sexyyou don't have to look like Beyonce, test me”. Sådan lød en tekstbid fra Phlake i P3’s “ugens uundgåelige” i uge 39 denne sensommer. Phlake hylder, med et solidt R&B beat, i hittet “Pregnant” hans kærestes gravide krop OG den særprægede længsel efter Oreos og...

  17. Betydelsen av historisk rättvisa efter kolonialismen

    Directory of Open Access Journals (Sweden)

    Göran Collste

    2012-05-01

    Full Text Available Artikeln tar sin utgångspunkt i två aktuella exempel på krav på historisk rättvisa efter kolonialismen: forna Mau-Mau-kämpars krav på gottgörelse för britternas övergrepp på 1950-talet och hererofolkets krav till Tyskland på gottgörelse för det folkmord som ägde rum 1904–1907. Dessa exempel aktualiserar frågan om historisk rättvisa. Vad innebär historisk rättvisa? Vilka krav på historisk rättvisa är berättigade att ställa? Hur lång tid efter övergrepp och våld finns det skäl att kräva gottgörelse? Kan kraven ärvas till efterkommande generationer? Vem bör gottgöra dem som drabbats? Dessa frågor måste besvaras för att man skall kunna ta ställning till krav på gottgörelse och rättvisa. Syftet med denna artikel är att identifiera och söka besvara en rad frågor som krav på gottgörande rättvisa efter kolonialismen ställer. Avslutningsvis diskuteras kraven från Mau-Mau-kämparna som var internerade i brittiska läger och hererofolkets krav på kompensation från Tyskland.Nyckelord: Gottgörande rättvisa, kompensation, kolonialism, herero, Mau-Mau, global rättvisa, historisk rättvisaEnglish summary: The Meaning of Historical Justice after ColonialismRecently, four Kikuyus and former Kenyan Mau-Mau fighters claimed compensation for castration, torture and rape committed in the British detention camps in the 1950s. Also recently, representatives of the Herero people went to Berlin to bring home skulls that Germans brought to Berlin after the genocide at the beginning of the Twentieth Century. The detentions and abuses of Kikuyu and the genocide of the Herero people are just two examples of offenses carried out by European nations during colonialism. Do these offenses have any reverberations today? Should we simply forget about the deeds that happened such a long time ago or do they raise any legal or moral questions?The concept of justice has two dimensions, distributional and rectificatory. This

  18. Amphiphilic polymeric micelles as the nanocarrier for peroral delivery of poorly soluble anticancer drugs.

    Science.gov (United States)

    Tian, Ye; Mao, Shirui

    2012-06-01

    Many amphiphilic copolymers have recently been synthesized as novel promising micellar carriers for the delivery of poorly water-soluble anticancer drugs. Studies on the formulation and oral delivery of such micelles have demonstrated their efficacy in enhancing drug uptake and absorption, and exhibit prolonged circulation time in vitro and in vivo. In this review, literature on hydrophobic modifications of several hydrophilic polymers, including polyethylene glycol, chitosan, hyaluronic acid, pluronic and tocopheryl polyethylene glycol succinate, is summarized. Parameters influencing the properties of polymeric micelles for oral chemotherapy are discussed and strategies to overcome main barriers for polymeric micelles peroral absorption are proposed. During the design of polymeric micelles for peroral chemotherapy, selecting or synthesizing copolymers with good compatibility with the drug is an effective strategy to increase drug loading and encapsulation efficiency. Stability of the micelles can be improved in different ways. It is recommended to take permeability, mucoadhesion, sustained release, and P-glycoprotein inhibition into consideration during copolymer preparation or to consider adding some excipients in the formulation. Furthermore, both the copolymer structure and drug loading methods should be controlled in order to get micelles with appropriate particle size for better absorption.

  19. Iron intake by rats using peroral administration of /sup 55/Fe-salts of phosphatidic acids

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, P.; Kas, J. (Inst. of Chemical Technology, Prague (Czechoslovakia)); Tykva, R. (Ceskoslovenska Akademie Ved, Prague. Ustav Organicke Chemie a Biochemie)

    1984-03-15

    The utilization of /sup 55/Fe and its incorporation into rat organs was investigated after peroral administration of various salts of phosphatidic acids (PA). Iron of PA salts is utilized up to 58-94% comparing to /sup 55/Fe/sup 2 +/. The degree of iron utilization depends on the type of PA salts administered. 16 refs.

  20. Støtte til mestring i udredningstiden efter indførelse af kræftpakken

    DEFF Research Database (Denmark)

    Adellund, Kamila; Frandsen, Helle Nørtved; Juhl, Inger Rudbeck

    2009-01-01

    I Danmark er de seneste år startet flere kræftskoler, som giver tilbud om uddannelse og støtte efter behandlingen. Der findes imidlertid ingen tilbud, der retter sig mod patienter og pårørende i udredningstiden. Gynækologisk Obstetrisk Afdeling D, Odense Universitetshospital, har fra Kræftens Bek...... kvalitative og kvantitative forskningsmetoder og der skal evalueres på støtteprogrammets effekt. Projektet starter medio maj 2009 og afsluttes ultimo 2010....

  1. Magnetic resonance cholangiopancreatography (MRCP) using new negative per-oral contrast agent based on superparamagnetic iron oxide nanoparticles for extrahepatic biliary duct visualization in liver cirrhosis.

    Science.gov (United States)

    Polakova, Katerina; Mocikova, Ingrid; Purova, Dana; Tucek, Pavel; Novak, Pavel; Novotna, Katerina; Izak, Niko; Bielik, Radoslav; Zboril, Radek; Miroslav, Herman

    2016-12-01

    Magnetic resonance cholangiopancreatography (MRCP) is often used for imaging of the biliary tree and is required by surgeons before liver transplantation. Advanced liver cirrhosis and ascites in patients however present diagnostic problems for MRCP. The aim of this study was to find out if the use of our negative per-oral contrast agent containing superparamagnetic iron oxide nanoparticles (SPIO) in MRCP is helpful for imaging of hepatobiliary tree in patients with liver cirrhosis. Forty patients with liver cirrhosis were examined on a 1.5 T MR unit using standard MRCP protocol. Twenty patients (group A) underwent MRCP after administration of per-oral SPIO contrast agent 30 min before examination. In group B, twenty patients were examined without per-oral bowel preparation. Ascites was present in eleven patients from group A and in thirteen patients in group B. Four radiologists analyzed MR images for visibility and delineation of the biliary tree. χ 2 tests were used for comparison of the visibility of intrahepatic and extrahepatic biliary ducts in patients with and without ascites. Better extrahepatic biliary duct visualization and visibility of extraluminal pathologies in patients with ascites was proved after administration of SPIO contrast agent. No statistically significant difference between group A and B was found for visualization of extrahepatic biliary ducts in patients without ascites. Delineation of intrahepatic biliary ducts was independent on bowel preparation. Application of our negative per-oral SPIO contrast agent before MRCP improves the visualization of extrahepatic biliary ducts in patients with ascites which is helpful during the liver surgery, mainly in liver transplantation.

  2. Att drabbas av cancer i tonåren : En kvantitativ studie om hälsorelaterad livskvalitet två till fyra år efter diagnos

    OpenAIRE

    Hiding, Markus; Lavemark, Niklas

    2010-01-01

    Syfte Studiens syfte var att undersöka: självskattad hälsorelaterad livskvalitet hos tonåringar som drabbats av cancer två år (T5), tre år (T6) och fyra år (T7) efter diagnos, samt att jämföra deras skattningar med en referensgrupp randomiserad från befolkningen.   Metod Tonåringarna med cancer besvarade SF-36 2 år (N=38), 3 år (N=42) samt 4 år (N=39) efter diagnos. En referensgrupp (N=300) randomiserad av Statistiska centralbyrån (SCB) besvarade samma formulär vid ett tillfälle. Samtlig data...

  3. Prevention and treatment of colon cancer by peroral administration of HAMLET (human α-lactalbumin made lethal to tumour cells).

    Science.gov (United States)

    Puthia, Manoj; Storm, Petter; Nadeem, Aftab; Hsiung, Sabrina; Svanborg, Catharina

    2014-01-01

    Most colon cancers start with dysregulated Wnt/β-catenin signalling and remain a major therapeutic challenge. Examining whether HAMLET (human α-lactalbumin made lethal to tumour cells) may be used for colon cancer treatment is logical, based on the properties of the complex and its biological context. To investigate if HAMLET can be used for colon cancer treatment and prevention. Apc(Min)(/+) mice, which carry mutations relevant to hereditary and sporadic human colorectal tumours, were used as a model for human disease. HAMLET was given perorally in therapeutic and prophylactic regimens. Tumour burden and animal survival of HAMLET-treated and sham-fed mice were compared. Tissue analysis focused on Wnt/β-catenin signalling, proliferation markers and gene expression, using microarrays, immunoblotting, immunohistochemistry and ELISA. Confocal microscopy, reporter assay, immunoprecipitation, immunoblotting, ion flux assays and holographic imaging were used to determine effects on colon cancer cells. Peroral HAMLET administration reduced tumour progression and mortality in Apc(Min)(/+) mice. HAMLET accumulated specifically in tumour tissue, reduced β-catenin and related tumour markers. Gene expression analysis detected inhibition of Wnt signalling and a shift to a more differentiated phenotype. In colon cancer cells with APC mutations, HAMLET altered β-catenin integrity and localisation through an ion channel-dependent pathway, defining a new mechanism for controlling β-catenin signalling. Remarkably, supplying HAMLET to the drinking water from the time of weaning also significantly prevented tumour development. These data identify HAMLET as a new, peroral agent for colon cancer prevention and treatment, especially needed in people carrying APC mutations, where colon cancer remains a leading cause of death.

  4. Surgery or Peroral Esophageal Myotomy for Achalasia

    Science.gov (United States)

    Marano, Luigi; Pallabazzer, Giovanni; Solito, Biagio; Santi, Stefano; Pigazzi, Alessio; De Luca, Raffaele; Biondo, Francesco Giuseppe; Spaziani, Alessandro; Longaroni, Maurizio; Di Martino, Natale; Boccardi, Virginia; Patriti, Alberto

    2016-01-01

    Abstract To date very few studies with small sample size have compared peroral esophageal myotomy (POEM) with the current surgical standard of care, laparoscopic Heller myotomy (LHM), in terms of efficacy and safety, and no recommendations have been proposed. To investigate the efficacy and safety of POEM compared with LHM, for the treatment of achalasia. The databases of Pubmed, Medline, Cochrane, and Ovid were systematically searched between January 1, 2005 and January 31, 2015, with the medical subject headings (MeSH) and keywords “achalasia,” “POEM,” “per oral endoscopic myotomy,” and “peroral endoscopic myotomy,” “laparoscopic Heller myotomy” (LHM), “Heller myotomy.” All types of study designs including adult patients with diagnosis of achalasia were selected. Studies that did not report the comparison between endoscopic and surgical treatment, experimental studies in animal models, single case reports, technical reports, reviews, abstracts, and editorials were excluded. The total number of included patients was 486 (196 in POEM group and 290 in LHM group). There were no differences between POEM and LHM in reduction in Eckardt score (MD = −0.659, 95% CI: −1.70 to 0.38, P = 0.217), operative time (MD = −0.354, 95% CI: −1.12 to 0.41, P = 0.36), postoperative pain scores (MD = −1.86, 95% CI: −5.17 to 1.44, P = 0.268), analgesic requirements (MD = −0.74, 95% CI: −2.65 to 1.16, P = 0.445), and complications (OR = 1.11, 95% CI: 0.5–2.44, P = 0.796). Length of hospital stay was significantly lower for POEM (MD = −0.629, 95% CI: −1.256 to −0.002, P = 0.049). There was a trend toward significant reduction in symptomatic gastroesophageal reflux rate in favors of LHM compared to POEM group (OR = 1.81, 95% CI: 1.11–2.95, P = 0.017). All included studied were not randomized. Furthermore all selected studies did not report the results of follow-up longer than 1 year and

  5. Development of a VR training system of robotic peroral operation procedure for endoscopic surgery of digestive tracts

    International Nuclear Information System (INIS)

    Suzuki, Naoki; Hattori, Asaki; Tanoue, Kazuo; Ieiri, Satoshi; Konishi, Kozo; Tomikawa, Morimasa; Kenmotsu, Hajime; Hashizume, Makoto

    2010-01-01

    This report presents the development of a VR (virtual real) training system of robotic peroral operation procedure for endoscopic resection of gastric mucosa as the training is essential because the procedure differs from usual one hitherto. For VR operation space, used is reporters' sphere-filled organ model (SFM), which is deformed by and repels to, the outside force as a soft tissue rapidly in the real time. The deformation and repellence are computable. The SFM space is reconstructed to 3D of the inner environment of stomach using MRI data. The endoscope has, at the right and left side of its top, 2 arms of inner needle knife-equipped robotic forceps and is inserted perorally for operation. In VR, the forceps can grab the gastric mucosa, cut it with the knife to complete resection and carry the specimen out of the body. For the procedure training, the time required for hemostasis, bleeding volume, trace of the arms, intensity and direction of the outer force given are recorded, with which trainee's safety and degree of skill are evaluable in VR. Hydration step and clipping to close the wound are to be further added in the procedure. (T.T.)

  6. Structural Changes of the Testis and Changes in Semen Quality Parameters Caused by Intraperitoneal and Peroral Administration of Selenium in Rats

    Directory of Open Access Journals (Sweden)

    Michal Cabaj

    2012-05-01

    Full Text Available The aim of this study was to find the structural changes in the testis and semen quality parameters of rat after a singleintraperitoneal and repeated peroral selenium administration. Rats were killed 36 hours following the intraperitonealadministration of selenium selenite (2 mg.kg-1 b.w.; 98% purity and after 90 days of the peroral repeatedadministration of selenium in drinking water (5 mg.l-1. Testis samples were evaluated by histological andmorphometrical methods in light microscopy. Evaluation of semen samples were examined with CASA method. 36hours after the selenium i.p. administration, damage of cellular associations, release of necrotised epithelial cells totubule lumen and fibrotisation and extension of interstitium were observed. Morphometry methods have shown thereduction of seminiferous epithelium volume (P<0.001, extension of interstitium (P<0.001 and increased area ofintraepithelial spaces (P<0.01. In p.o. group similar but more intense changes were noted; in addition, occasionalldegeneration of seminiferous tubuli and rarely total damage in histoarchitecture of seminiferous epithelium wereobserved. CASA analysis revealed significant decrease in all parameters except the concentration of spermatozoa.Additionally, we suppose that p.o. dose 5 mg.l-1 sodium selenite in drinking water is minimum lethal dose level foryoung rats. Selenium after i.p. and p.o. administration causes damage of seminiferous epithelium and interstitium. Itleads to changes in relative proportion of functional tissues of the testis. Reduced spermatogenesis and harmfuleffects in semen parameters are characteristic especially for peroral repeated (subchronic administration. Thesechanges are time- and dose-dependent. In both dosage methods subfertility or infertility can appear.

  7. Peroral Endoscopic Myotomy for the Treatment of Achalasia: An Analysis

    Directory of Open Access Journals (Sweden)

    Dennis Yang

    2013-01-01

    Full Text Available Achalasia is a motility disorder of the esophagus, characterized by aperistalsis of the esophageal body and incomplete relaxation of the lower esophageal sphincter (LES. Treatment of achalasia is currently aimed at decreasing the resting pressure in the LES. Peroral endoscopic myotomy (POEM is an emerging novel endoscopic procedure for the treatment of achalasia with initial data suggesting an acceptable safety profile, excellent short-term symptom resolution, low incidence of postprocedural gastroesophageal reflux (GER, and improvement in manometric outcomes. Further prospective randomized trials are required to evaluate the long-term effectiveness of this promising technique compared to other treatment modalities for achalasia. In this review we outline the technical aspects of POEM, summarize the available data on safety and outcomes, and suggest future directions for further advancement of this minimally invasive approach for the treatment of achalasia.

  8. Amelioration of radiation damage to haemopoiesis by Ivastimul, given after irradiation to mice protected by peroral cystamine

    International Nuclear Information System (INIS)

    Vacek, A.; Rotkovska, D.; Bartonickova, A.; Kautska, J.

    1992-01-01

    Combined radioprotection by preirradiation peroral cystamine and postirradiation Ivastimul administration was examined in sublethally and lethally whole-body gamma-irradiated mice. Enhancement of haemopoietic recovery and increased survival of irradiated mice was demonstrated for a single dose of Ivastimul administered after irradiation. The ameliorative influence of combined radioprotection may be explained by haemopoietic stem cell protection by cystamine and haemopoietic stimulation mediated by Ivastimul. (author) 2 tabs., 3 figs., 20 refs

  9. Unsedated peroral wireless pH capsule placement vs. standard pH testing: A randomized study and cost analysis

    Directory of Open Access Journals (Sweden)

    Andrews Christopher N

    2012-05-01

    Full Text Available Abstract Background Wireless capsule pH-metry (WC is better tolerated than standard nasal pH catheter (SC, but endoscopic placement is expensive. Aims: to confirm that non-endoscopic peroral manometric placement of WC is as effective and better tolerated than SC and to perform a cost analysis of the available esophageal pH-metry methods. Methods Randomized trial at 2 centers. Patients referred for esophageal pH testing were randomly assigned to WC with unsedated peroral placement or SC after esophageal manometry (ESM. Primary outcome was overall discomfort with pH-metry. Costs of 3 different pH-metry strategies were analyzed: 1 ESM + SC, 2 ESM + WC and 3 endoscopically placed WC (EGD + WC using publicly funded health care system perspective. Results 86 patients (mean age 51 ± 2 years, 71% female were enrolled. Overall discomfort score was less in WC than in SC patients (26 ± 4 mm vs 39 ± 4 mm VAS, respectively, p = 0.012 but there were no significant group differences in throat, chest, or overall discomfort during placement. Overall failure rate was 7% in the SC group vs 12% in the WC group (p = 0.71. Per patient costs ($Canadian were $1475 for EGD + WC, $1014 for ESM + WC, and $906 for ESM + SC. Decreasing the failure rate of ESM + WC from 12% to 5% decreased the cost of ESM + WC to $991. The ESM + SC and ESM + WC strategies became equivalent when the cost of the WC device was dropped from $292 to $193. Conclusions Unsedated peroral WC insertion is better tolerated than SC pH-metry both overall and during placement. Although WC is more costly, the extra expense is partially offset when the higher patient and caregiver time costs of SC are considered. Trial registration Clinicaltrials.gov Identifier NCT01364610

  10. Peroral Endoscopic Myotomy for Treating Achalasia and Esophageal Motility Disorders

    Science.gov (United States)

    Youn, Young Hoon; Minami, Hitomi; Chiu, Philip Wai Yan; Park, Hyojin

    2016-01-01

    Peroral endoscopic myotomy (POEM) is the application of esophageal myotomy to the concept of natural orifice transluminal surgery (NOTES) by utilizing a submucosal tunneling method. Since the first case of POEM was performed for treating achalasia in Japan in 2008, this procedure is being more widely used by many skillful endosopists all over the world. Currently, POEM is a spotlighted, emerging treatment option for achalasia, and the indications for POEM are expanding to include long-standing, sigmoid shaped esophagus in achalasia, even previously failed endoscopic treatment or surgical myotomy, and other spastic esophageal motility disorders. Accumulating data about POEM demonstrate excellent short-term outcomes with minimal risk of major adverse events, and some existing long-term data show the efficacy of POEM to be long lasting. In this review article, we review the technical details and clinical outcomes of POEM, and discuss some considerations of POEM in special situations. PMID:26717928

  11. Peroral endoscopic myotomy (POEM) for treating esophageal motility disorders

    Science.gov (United States)

    Wong, Ian

    2017-01-01

    Pneumatic dilatation and Heller myotomy have been thoroughly studied as the most viable treatment options for achalasia. The pendulum, however, is shifting to the minimally invasive approach. Since Inoue et al. published the experience of the first 17 cases of peroral endoscopic myotomy (POEM) in 2010, there have been at least 5,000 cases performed worldwide and the number is increasing exponentially. Experts across the globe have been extending the indications to various esophageal motility disorders, to patients of extremes of age, sigmoidal esophagus and re-operated patients. There are a few variations in technique across different centers in defining the gastroesophageal junction (GEJ) and adequacy of myotomy, the optimal length, site of myotomy and whether the full thickness of the muscle wall should be cut. Large case series demonstrated its promising efficacy & reasonable complication profile. Randomized controlled trial in comparison with the gold standard, Heller myotomy, is ongoing. The future application of submucosal tunnelling technique is thrilling with its extension in tumour resection, antropyloromyotomy and other natural orifice transluminal endoscopic surgery (NOTES). PMID:28616407

  12. Pharmacokinetics of Caffeine in the Lens Capsule/Epithelium After Peroral Intake: A Pilot Randomized Controlled Study.

    Science.gov (United States)

    Kronschläger, Martin; Stimpfl, Thomas; Ruiß, Manuel; Hirnschall, Nino; Leisser, Christoph; Findl, Oliver

    2018-04-01

    To determine the pharmacokinetics of perorally administered caffeine, a widely consumed and potent dietary antioxidant, in the anterior lens capsule and lens epithelial cells, a crucial cell monolayer for cataract development. Bilateral cataract patients were scheduled for cataract surgery with a caffeine abstinence of 1 week before surgery of each eye. At the day of surgery of the second eye patients were administered no drink (0-mg group) or coffee with 60-, 120-, or 180-mg caffeine. After capsulorhexis the lens capsule including lens epithelial cells was transferred to a test tube for analysis of caffeine concentration by gas chromatography-mass spectrometry (GC-MS/MS). Coffee consumption significantly (P < 0.05) increased caffeine levels of the lens capsule/epithelium in the 60-, 120-, and 180-mg group. Caffeine concentrations (caffeine ng/lens capsule/epithelium) measured as difference between 1st and 2nd eye were -0.52 ± 1.16 (0-mg group, n = 7), 1.88 ± 2.02 (60-mg group, n = 8), 2.09 ± 0.67 (120-mg group, n = 9), and 3.68 ± 1.86 (180-mg group, n = 9). The increase constant of caffeine in a linear regression model was estimated as a 95% CI 0.02 ± 0.0046 (degrees of freedom; 25; r = 0.85). Peroral intake of coffee significantly increased caffeine concentrations in the lens capsule and lens epithelial cells in a dose-dependent manner. This information is important for further investigations on preventing cataract.

  13. Esophageal motility after peroral endoscopic myotomy for achalasia.

    Science.gov (United States)

    Hu, Yue; Li, Meng; Lu, Bin; Meng, Lina; Fan, Yihong; Bao, Haibiao

    2016-05-01

    Peroral endoscopic myotomy (POEM) has been introduced as a novel endoscopic treatment for achalasia. The aim of this work is to assess the changes in esophageal motility caused by POEM in patients with achalasia. Forty-one patients with achalasia underwent POEM from September 2012 to November 2014. Esophageal motility of all patients was evaluated preoperatively and 1 month after POEM utilizing high-resolution manometry, which was performed with ten water swallows, ten steamed bread swallows, and multiple rapid swallows (MRS). In single swallows, including liquid swallows and bread swallows, all the parameters of lower esophagus sphincter resting pressure (LESP), 4-s integrated relaxation pressure (4sIRP), and intra-bolus pressure (IBP) were decreased between pre- and post-POEM patients (all p 0.05), but increased in subtype I (subtype I: p > 0.05). In liquid swallows, the Eckardt score of subtype II patients decreased with DCI, and distal esophageal peristaltic amplitude after POEM was significantly lower compared with those showing increased values of those two parameters (p achalasia patients. POEM reduces LES pressure in achalasia, and partly restores esophageal motility. POEM displayed varying effect on esophageal motility in patients with different patterns of swallowing. In addition, the changes in parameters associated with esophageal peristalsis correlated with decreases in Eckardt score.

  14. Effect of Peroral Administration of Chromium on Insulin Signaling Pathway in Skeletal Muscle Tissue of Holstein Calves.

    Science.gov (United States)

    Jovanović, Ljubomir; Pantelić, Marija; Prodanović, Radiša; Vujanac, Ivan; Đurić, Miloje; Tepavčević, Snežana; Vranješ-Đurić, Sanja; Korićanac, Goran; Kirovski, Danijela

    2017-12-01

    The objective of this study was to investigate the effects of peroral administration of chromium-enriched yeast on glucose tolerance in Holstein calves, assessed by insulin signaling pathway molecule determination and intravenous glucose tolerance test (IVGTT). Twenty-four Holstein calves, aged 1 month, were chosen for the study and divided into two groups: the PoCr group (n = 12) that perorally received 0.04 mg of Cr/kg of body mass daily, for 70 days, and the NCr group (n = 12) that received no chromium supplementation. Skeletal tissue samples from each calf were obtained on day 0 and day 70 of the experiment. Chromium supplementation increased protein content of the insulin β-subunit receptor, phosphorylation of insulin receptor substrate 1 at Tyrosine 632, phosphorylation of Akt at Serine 473, glucose transporter-4, and AMP-activated protein kinase in skeletal muscle tissue, while phosphorylation of insulin receptor substrate 1 at Serine 307 was not affected by chromium treatment. Results obtained during IVGTT, which was conducted on days 0, 30, 50, and 70, suggested an increased insulin sensitivity and, consequently, a better utilization of glucose in the PoCr group. Lower basal concentrations of glucose and insulin in the PoCr group on days 30 and 70 were also obtained. Our results indicate that chromium supplementation improves glucose utilization in calves by enhancing insulin intracellular signaling in the skeletal muscle tissue.

  15. Peroral endoscopic myotomy: An emerging minimally invasive procedure for achalasia

    Science.gov (United States)

    Vigneswaran, Yalini; Ujiki, Michael B

    2015-01-01

    Peroral endoscopic myotomy (POEM) is an emerging minimally invasive procedure for the treatment of achalasia. Due to the improvements in endoscopic technology and techniques, this procedure allows for submucosal tunneling to safely endoscopically create a myotomy across the hypertensive lower esophageal sphincter. In the hands of skilled operators and experienced centers, the most common complications of this procedure are related to insufflation and accumulation of gas in the chest and abdominal cavities with relatively low risks of devastating complications such as perforation or delayed bleeding. Several centers worldwide have demonstrated the feasibility of this procedure in not only early achalasia but also other indications such as redo myotomy, sigmoid esophagus and spastic esophagus. Short-term outcomes have showed great clinical efficacy comparable to laparoscopic Heller myotomy (LHM). Concerns related to postoperative gastroesophageal reflux remain, however several groups have demonstrated comparable clinical and objective measures of reflux to LHM. Although long-term outcomes are necessary to better understand durability of the procedure, POEM appears to be a promising new procedure. PMID:26468336

  16. Per-oral endoscopic myotomy for esophageal achalasia in a case of Allgrove syndrome.

    Science.gov (United States)

    Nakamura, Jun; Hikichi, Takuto; Inoue, Haruhiro; Watanabe, Ko; Kikuchi, Hitomi; Takagi, Tadayuki; Suzuki, Rei; Sugimoto, Mitsuru; Konno, Naoki; Waragai, Yuichi; Asama, Hiroyuki; Takasumi, Mika; Sato, Yuki; Irie, Hiroki; Obara, Katsutoshi; Ohira, Hiromasa

    2018-01-30

    Allgrove syndrome, also known as Triple A syndrome, is a rare autosomal recessive genetic disease characterized by three signs: esophageal achalasia, adrenocorticotropic hormone refractoriness, and alacrima. A 31-year-old male presented to our hospital for treatment of difficulty swallowing caused by esophageal achalasia. Because he had complicating alacrima, a neurologic disease, and a family history of consanguineous marriage, a genetic neurologic disease was suspected. Then, a mutation in the achalasia-addisonianism-alacrima syndrome gene was identified. With the diagnosis of Allgrove syndrome, a per-oral endoscopic myotomy (POEM) was performed for esophageal achalasia. After the POEM, the symptoms and the esophageal pressure findings ameliorated quickly, with no recurrence noted throughout a follow-up of more than 1 year. Here, we report the first case of POEM performed for esophageal achalasia in Allgrove syndrome.

  17. Udvikling af antistoffer efter vaccination mod og podning med PRRSV

    DEFF Research Database (Denmark)

    Sonne Kristensen, Charlotte; Qvist Pawlowski, Mia; Thoning, Henrik

    konkludere, at det er muligt at vaccinere med begge PRRS vacciner på samme tid og opnå antistofsvar for begge typer PRRSV. Husk dog altid at give forskellige vacciner i hver sin side af nakken. Blodprøver fra grisene viste, at de havde dannet antistoffer og blev positive i ELISA-testen for PRRSV Type 1 21......-US samt IPT testene. Disse tests kan dog ikke skelne ”eksotiske” PRRSV subtyper fra de almindelige cirkulerende PRRSV subtyper i Danmark. Forsøget blev gennemført på Lindholm. Der indgik 66 grise fra en Blå SPF+Ap6+Ap12 besætning. Grisene blev ved ankomst fordelt i 4 grupper (VAC-T1, VAC-T2, VAC-T1T2 og...... NON-VAC): VAC-T1 blev vaccineret med Porcilis ® PRRS VET VAC-T2 blev vaccineret med Ingelvac ® PRRS VET VAC-T1T2 fik begge vacciner samtidig i hver sin side af nakken NON-VAC blev ikke vaccineret. Grisene blev gennem hele forsøget observeret dagligt. De fik taget temperatur den første uge efter...

  18. Contrast amplification of the liver parenchyma in the computer tomogram by using intravenous and peroral biliary contrast media

    International Nuclear Information System (INIS)

    Justich, E.; Sager, W.D.; Dietrich, G.; Fotter, R.; Nedden, D. zur; Innsbruck Univ.

    1980-01-01

    If intravenous, biliary contrast media are used, a slight albeit specific enhancement of contrast of the liver parenchyma occurs with the applied dosage, which can be utilised in individual cases, for example for identifying isodense lesions. Contrast amplification by the peroral cholegraphic agent under examination, is insufficient for use in computer tomography of the liver. The use of biliary contrast media usually enables very good visualisation of the extrahepatic bile ducts. Attention is drawn to the possibility of pharmakokinetic studies by means of computer tomography. (orig.) [de

  19. Peroral endoscopic cardial constriction in gastroesophageal reflux disease.

    Science.gov (United States)

    Hu, Hai-Qing; Li, Hui-Kai; Xiong, Ying; Zhang, Xiao-Bin; Zhi, Jun-Li; Wang, Xiao-Xiao; Ling-Hu, En-Qiang

    2018-04-01

    Gastroesophageal reflux disease (GERD) is a major digestive health problem with a high and increasing incidence worldwide. Peroral endoscopic cardial constriction (PECC) was developed by our group to provide a less invasive treatment for GERD.In this preliminary follow-up study, 16 patients were enrolled and 13 patients with GERD were targeted for analysis according to the Los Angeles classification of reflux esophagitis. The GERD health-related quality of life (GERD-HRQL) scale and esophageal pH monitoring were applied to assess clinical efficiency at 3 and 6 months after PECC treatment, respectively.All GERD patients successively received PECC, and no severe treatment-related complication was reported. Before PECC treatment, the GERD-HRQL scale was 19.92 ± 7.89. At 3 and 6 months after treatment, the GERD-HRQL scale was 4.46 ± 4.31 and 5.69 ± 5.07, respectively. DeMeester score was 125.50 ± 89.64 before PECC treatment, and 16.97 ± 12.76 and 20.32 ± 15.22 at 3 and 6 months after PECC treatment. Furthermore, the fraction time of a pH below 4 significantly decreased at 3 and 6 months after PECC treatment. Fraction time at pH reflux of stomach contents.

  20. Rehabilitering efter dekompression och diskoperation - framställandet av en fysioterapeutisk patientanvisning : Ett beställningsarbete av Tölö sjukhus

    OpenAIRE

    Nyberg, Jasmina

    2016-01-01

    Examensarbetet är ett praktiskt inriktat examensarbete med fokus på rehabiliteringen efter en dekompressions- och diskoperation. Det är ett beställningsarbete av Tölö sjukhus med syftet att framställa en fysioterapeutisk patientanvisning. Önskemål från uppdragsgivare var att utforma en tydlig patientanvisning för ryggopererade bestående av skriftliga instruktioner angående postoperativ rehabilitering i form av vardagliga aktiviteter, fysisk aktivitet, ryggens viloställningar, vi...

  1. Per-oral endoscopic myotomy for achalasia: An American perspective

    Science.gov (United States)

    Friedel, David; Modayil, Rani; Iqbal, Shahzad; Grendell, James H; Stavropoulos, Stavros N

    2013-01-01

    Achalasia is an uncommon esophageal motility disorder characterized by the selective loss of enteric neurons leading to absence of peristalsis and impaired relaxation of the lower esophageal sphincter. Per-oral endoscopic myotomy (POEM) is a novel modality for the treatment of achalasia performed by gastroenterologists and surgeons. It represents a natural orifice transluminal endoscopic surgery (NOTES) approach to Heller myotomy. POEM has the minimal invasiveness of an endoscopic procedure that can duplicate results of the surgical Heller myotomy. POEM is conceptually similar to a surgical myotomy without the inherent external incisions and post-operative care associated with surgery. Initial high success and low complications rates promise a great future for this technique. In fact, POEM has been successfully performed on patients with end-stage achalasia as an initial treatment reserving esophagectomy for those without good response. The volume of POEMs performed worldwide has grown exponentially. In fact, surgeons who have performed Heller myotomy have embraced POEM as the preferred intervention for achalasia. However, the niche of POEM remains to be defined and long term results are awaited. We describe our experience with POEM having performed the first POEM outside of Japan in 2009, the evolution of our technique, and give our perspective on its future. PMID:24044040

  2. Peroral endoscopic myotomy (POEM): feasible as reoperation following Heller myotomy.

    Science.gov (United States)

    Vigneswaran, Yalini; Yetasook, Amy K; Zhao, Jin-Cheng; Denham, Woody; Linn, John G; Ujiki, Michael B

    2014-06-01

    The purpose of this study was to demonstrate the feasibility of performing peroral endoscopic myotomy (POEM) in the management of recurrent achalasia after failed myotomy. Eight patients presented to our institution between October 2010 and June 2013 with recurrent/persistent symptoms after prior laparoscopic Heller myotomy. Three patients underwent redo laparoscopic Heller myotomy, and five patients consented to redo myotomy with POEM. Demographics were similar between the groups with exception of age (POEM 69.5 vs. laparoscopic Heller myotomy (LHM) 34.5, p = 0.003). Preoperative Eckardt scores, motility, and prior interventions were not significantly different. Three patients who underwent POEM and two who underwent laparoscopic Heller myotomy had prior fundoplication. There was one perforation identified after laparoscopic Heller myotomy and one patient with persistent subcutaneous emphysema after POEM. Both POEM and laparoscopic Heller myotomy demonstrated significant improvement in symptoms and Eckardt scores at average follow-up of approximately 5 months (p myotomy even in the presence of prior fundoplication. The procedure can be performed safely using a similar technique as for primary myotomy with the exception of creating the myotomy laterally along the right side of the esophagus and lesser curvature avoiding the previous anterior myotomy.

  3. Per-oral endoscopic myotomy: Major advance in achalasia treatment and in endoscopic surgery

    Science.gov (United States)

    Friedel, David; Modayil, Rani; Stavropoulos, Stavros N

    2014-01-01

    Per-oral endoscopic myotomy (POEM) represents a natural orifice endoscopic surgery (NOTES) approach to laparoscopy Heller myotomy (LHM). POEM is arguably the most successful clinical application of NOTES. The growth of POEM from a single center in 2008 to approximately 60 centers worldwide in 2014 with several thousand procedures having been performed attests to the success of POEM. Initial efficacy, safety and acid reflux data suggest at least equivalence of POEM to LHM, the previous gold standard for achalasia therapy. Adjunctive techniques used in the West include impedance planimetry for real-time intraprocedural luminal assessment and endoscopic suturing for challenging mucosal defect closures during POEM. The impact of POEM extends beyond the realm of esophageal motility disorders as it is rapidly popularizing endoscopic submucosal dissection in the West and spawning offshoots that use the submucosal tunnel technique for a host of new indications ranging from resection of tumors to pyloromyotomy for gastroparesis. PMID:25548473

  4. Food Consumption Patterns Of The Ozyorsk Population In 1948-1966, Important For Estimating Peroral Component Of Internal Exposure Doses

    International Nuclear Information System (INIS)

    Mokrov, Y.; Martyushov, V.Z.; Stukalov, Pavel M.; Ivanov, I.A.; Beregich, D.A.; Anspaugh, L.R.; Napier, Bruce A.

    2008-01-01

    Results of reconstruction of food consumption patterns are presented for the residents of Ozyorsk for the period of 1948-1966. The reconstruction was performed on the basis analysis of the archive data. The given period of time is characterized by maximum releases into the atmosphere from the Mayak PA sources, and, therefore, it is considered to be the most significant period for calculating peroral component contribution to effective exposure doses to the population. The paper describes main foodstuff suppliers (regions) and their economic indices, as well as delivery rates and consumption rates for most important foodstuffs (primarily whole milk).

  5. Efekt učení perorální endoskopické myotomie (POEM) během prvního roku ověřování metody v České republice

    Czech Academy of Sciences Publication Activity Database

    Doležel, R.; Martínek, J.; Švecová, H.; Špičák, J.; Juhásová, Jana

    2014-01-01

    Roč. 68, č. 4 (2014), s. 294-298 ISSN 1804-7874 R&D Projects: GA MZd(CZ) NT13634 Institutional support: RVO:67985904 Keywords : peroral endoscopic myotomy * esophageal achalasia * learning curve Subject RIV: FP - Other Medical Disciplines

  6. Peroral endoscopic myotomy as salvation technique post-Heller: International experience.

    Science.gov (United States)

    Tyberg, Amy; Sharaiha, Reem Z; Familiari, Pietro; Costamagna, Guido; Casas, Fernando; Kumta, Nikhil A; Barret, Maximilien; Desai, Amit P; Schnoll-Sussman, Felice; Saxena, Payal; Martínez, Guadalupe; Zamarripa, Felipe; Gaidhane, Monica; Bertani, Helga; Draganov, Peter V; Balassone, Valerio; Sharata, Ahmed; Reavis, Kevin; Swanstrom, Lee; Invernizzi, Martina; Seewald, Stefan; Minami, Hitomi; Inoue, Haruhiro; Kahaleh, Michel

    2018-01-01

    Treatment for achalasia has traditionally been Heller myotomy (HM). Despite its excellent efficacy rate, a number of patients remain symptomatic post-procedure. Limited data exist as to the best management for recurrence of symptoms post-HM. We present an international, multicenter experience evaluating the efficacy and safety of post-HM peroral endoscopic myotomy (POEM). Patients who underwent POEM post-HM from 13 centers from January 2012 to January 2017 were included as part of a prospective registry. Technical success was defined as successful completion of the myotomy. Clinical success was defined as an Eckardt score of ≤3 on 12-month follow up. Adverse events (AE) including anesthesia-related, operative, and postoperative complications were recorded. Fifty-one patients were included in the study (mean age 54.2, 47% male). Technical success was achieved in 100% of patients. Clinical success on long-term follow up was achieved in 48 patients (94%), with a mean change in Eckardt score of 6.25. Seven patients (13%) had AE: six experienced periprocedural mucosal defect treated endoscopically and two patients developed mediastinitis treated conservatively. For patients with persistent symptoms after HM, POEM is a safe salvation technique with good short-term efficacy. As a result of the challenge associated with repeat HM, POEM might become the preferred technique in this patient population. Further studies with longer follow up are needed. © 2017 Japan Gastroenterological Endoscopy Society.

  7. Peroral endoscopic myotomy for esophageal achalasia: clinical impact of 28 cases.

    Science.gov (United States)

    Minami, Hitomi; Isomoto, Hajime; Yamaguchi, Naoyuki; Matsushima, Kayoko; Akazawa, Yuko; Ohnita, Ken; Takeshima, Fuminao; Inoue, Haruhiro; Nakao, Kazuhiko

    2014-01-01

    The aim of the present study was to clarify the efficacy of peroral endoscopic myotomy (POEM) for esophageal achalasia. Twenty-eight esophageal achalasia patients who underwent POEM in our institution between August 2010 and October 2012 were enrolled. Under general anesthesia with tracheal intubation, initial incision was made on the anterior wall of the esophagus after submucosal injection. Submucosal tunnel was created and extended below the lower esophageal sphincter (LES) onto the gastric cardia. Subsequently, myotomy was done using triangle tip knife. After confirmation of smooth passage of scope through the esophagogastric junction, the entry was closed. Esophagogram and manometry study was done before and after the procedure. Also, subjective symptom score and Eckardt score were assessed before and 3 months after POEM. POEM was successfully done in all cases without any severe complications such as perforation and mediastinitis.Mean procedure time was 99.1 min (range 61-160) and mean myotomy length was 14.4 cm (range 10-18). Significant improvement was achieved in both esophagogram and endoscopic findings. Mean LES pressure was 71.2 mmHg (35.8-119.0) and 21.0 mmHg (6.7-41.0) before and after the procedure (P treatment of choice for esophageal achalasia. © 2013 The Authors. Digestive Endoscopy © 2013 Japan Gastroenterological Endoscopy Society.

  8. Effect of peroral esophageal myotomy for achalasia treatment: A Chinese study.

    Science.gov (United States)

    Lu, Bin; Li, Meng; Hu, Yue; Xu, Yi; Zhang, Shuo; Cai, Li-Jun

    2015-05-14

    To assess the safety and feasibility of peroral esophageal myotomy (POEM) in patients with achalasia. From January 2012 to March 2014, 50 patients (28 men, 22 women; mean age: 42.8 years, range: 14-70 years) underwent POEM. Pre- and postoperative symptoms were quantified using the Eckardt scoring system. Barium swallow and esophagogastroscopy were performed before and after POEM, respectively. Esophageal motility was evaluated in all patients, both preoperatively and one month after POEM treatment, using a high-resolution manometry system. Manometry data, Eckardt scores, lower esophageal sphincter pressure and barium swallow results were used to evaluate the effect of the procedure. POEM was successfully completed for all patients. The mean procedure time was 55.4 ± 17.3 min and the mean total length of myotomy of the circular esophagus was 10.5 ± 2.6 cm. No specific complications occurred, with the exception of two patients that developed asymptomatic pneumomediastinum and subcutaneous emphysema. Clinical improvement in symptoms was achieved in all patients. Approximately 77.5% of patients experienced weight gain 6 mo after POEM, with an average of 4.78 kg (range: 2-15 kg). The lower esophageal sphincter resting pressure, four second integrated relaxation pressure and Eckardt scores were all significantly reduced after POEM (Ps achalasia symptoms, improve gastroesophageal junction relaxation and restore esophageal body motility function, but not normal esophageal peristalsis.

  9. Functional restoration of the esophagus after peroral endoscopic myotomy for achalasia.

    Science.gov (United States)

    Huh, Cheal Wung; Youn, Young Hoon; Chung, Hyunsoo; Lee, Yong Chan; Park, Hyojin

    2017-01-01

    Peroral endoscopic myotomy (POEM) is a new efficacious treatment option for achalasia. We propose to define "esophageal remodeling" as the functional restoration of the esophagus that involves decreased lower esophageal sphincter (LES) pressure, recovery of esophageal body peristalsis, and reduction of luminal diameter. The aim of this study was to investigate "esophageal remodeling" after POEM for achalasia. We analyzed data from a prospectively collected database of POEM subjects, which included preoperative and 2-month postoperative Eckardt symptom scores, and results from esophageal high resolution manometry (HRM) and barium esophagogram (BE). We recruited 23 patients (13 male; mean age: 53.9 years) whose preoperative and postoperative HRM and BE results were available, from among 30 patients with achalasia who underwent POEM at two institutions between July 2013 and December 2015. All patients achieved clinical treatment success (Eckardt score≤3). Partial recovery of esophageal body peristalsis was noted in 1/5 patients with type I (20%), 6/11 with type II (54.5%), and 7/7 with type III (100%) achalasia after POEM. Pan-esophageal pressurization disappeared after POEM in 10/11 type II achalasia patients. The average diameter of the esophageal body after POEM was significantly decreased in all types of achalasia. POEM provided excellent clinical symptomatic relief and esophageal remodeling in terms of restoration of peristalsis and reduction in diameter of the esophageal body, especially in patients with type III achalasia.

  10. Training in peroral endoscopic myotomy (POEM) for esophageal achalasia

    Science.gov (United States)

    Eleftheriadis, Nicholas; Inoue, Haruhiro; Ikeda, Haruo; Onimaru, Manabu; Yoshida, Akira; Hosoya, Toshihisa; Maselli, Roberta; Kudo, Shin-ei

    2012-01-01

    Peroral endoscopic myotomy (POEM) has been developed in the context of natural orifice transluminal endoscopic surgery (NOTES) as a minimally invasive endoscopic treatment for symptomatic esophageal achalasia, which is a chronic progressive benign disease with severe morbidity and difficult management. Since September 2008, POEM has been successfully performed in more than 200 consecutive patients with symptomatic achalasia at the Digestive Disease Center of Showa University, Northern Yokohama Hospital, Yokohama, Japan, with excellent short- and long-term results and absence of serious complications. International experience of POEM within clinical studies is also promising. According to these results, POEM is considered as a safe procedure that can be applied to all achalasia patients. However, the low incidence of achalasia (0.3%–1% per 100,000 population), in combination with the potential serious complications related to the technically demanding POEM procedure, has made training difficult. There is therefore an urgent need for an animal model for training to decrease the learning curve. Further, there are other ethical and training issues to address. The pig is the most appropriate animal model for training in POEM due to its anatomy being similar to that of humans. The porcine esophagus has the advantage of easy mobilization due to absence of tight junctions to surrounding organs. A non-survival porcine model would be a simple, inexpensive, and reproducible animal model for training in POEM, without the need for concern about complications. A possible training process might first involve observation of POEM performed by specialists, then training on non-survival and survival porcine models, followed by training in humans under specialist guidance and finally, performance of POEM in humans. PMID:22888256

  11. Anesthetic management of peroral endoscopic myotomy for esophageal achalasia: a retrospective case series.

    Science.gov (United States)

    Tanaka, Eriko; Murata, Hiroaki; Minami, Hitomi; Sumikawa, Koji

    2014-06-01

    Peroral endoscopic myotomy (POEM) is a newly developed, less invasive treatment for esophageal achalasia that requires general anesthesia under positive pressure ventilation. In this retrospective case series, we describe the anesthetic management of 28 consecutive patients who underwent POEM for esophageal achalasia. Anesthesia was maintained with sevoflurane and remifentanil under positive pressure ventilation through a tracheal tube. Retained contents in the esophagus were evacuated just before anesthesia induction to prevent regurgitation into the trachea. The POEM procedure was performed using an orally inserted flexible fiberscope. Elevation of end-tidal carbon dioxide after initiating esophageal carbon dioxide insufflation was observed in all patients and was treated by minute adjustments to the ventilation volume. Scopolamine butylbromide-induced tachycardia in one patient was treated with landiolol hydrochloride, which is a short-acting beta 1-selective blocker. Minor subcutaneous emphysema around the neck was observed in one patient. POEM was successfully completed, and tracheas were extubated immediately after the procedure in all patients. Our findings suggest that prevention of aspiration pneumonia during anesthesia induction, preparation for carbon dioxide insufflation-related complications, and treatment of scopolamine butylbromide-induced tachycardia play important roles in safe anesthesia management of POEM for esophageal achalasia.

  12. [Effects of peroral endoscopic myotomy on esophageal dynamics in patients with esophageal achalasia].

    Science.gov (United States)

    Zhong, Yun-shi; Li, Liang; Zhou, Ping-hong; Xu, Mei-dong; Ren, Zhong; Zhu, Bo-qun; Yao, Li-qing

    2012-07-01

    To investigate the effects of peroral endoscopic myotomy(POEM) on esophageal dynamics in patients with esophageal achalasia. From September 2011 to November 2011, 20 cases with esophageal achalasia received POEM at the Endoscopic Center in the Zhongshan Hospital of Fudan University. Pre-operation esophageal dynamics of all the patients were evaluated by high resolution manometry(HRM) system and 3 days after operation the test was repeated. Lower esophagus sphincter resting pressure(LESP), 4-second integrated relaxation pressure(4sIRP), lower esophagus sphincter relax rate(LESRR), lower esophagus sphincter length(LESL), and esophageal manometry were analyzed. After POEM, LESP decreased from(29.1±17.0) mm Hg to(14.6±4.9) mm Hg, and decrease rate was 49.8%(P0.05). Esophageal peristaltic contraction was absent in all the 20 patients preoperatively. After POEM, changes in the esophageal contraction were seen in 7 patients, and peristalsis was noticed but was below normal level. There were no significant changes in peristalsis in the remaining 13 patients. POEM can significantly reduce LESP and 4sIRP in patients with achalasia, but can not affect the contraction of the esophagus.

  13. Per-Oral Endoscopic Myotomy (POEM) After Previous Laparoscopic Heller Myotomy Is Feasible and Safe in a Porcine Model.

    Science.gov (United States)

    Miles, Luke F; Frelich, Matthew J; Gould, Jon C; Dua, Kulwinder S; Jensen, Eric S; Kastenmeier, Andrew S

    2015-10-01

    We sought to evaluate the feasibility, safety, and difficulty of performing the per-oral endoscopic myotomy (POEM) procedure in the setting of a prior Heller myotomy using a survival porcine model. Four pigs underwent laparoscopic Heller myotomy with Dor partial anterior fundoplication followed by the POEM performed 4 weeks later. Two additional pigs served as controls, undergoing only the POEM. All procedures were completed without complications. The revisional POEM was not significantly more difficult than POEM controls based on procedure time, POEM procedure components, or procedure difficulty scores. Revisional POEM had a longer mean operative time when compared with Heller myotomy (126.0 vs. 83.8 min; PHeller myotomy is safe and feasible in the porcine model and has potential as an option for patients suffering from recurrent or persistent symptoms after failed surgical myotomy.

  14. Direct peroral cholangioscopy using an ultrathin endoscope: making technique easier

    Directory of Open Access Journals (Sweden)

    Javier Sola-Vera

    2014-01-01

    Full Text Available Background: Cholangioscopy is a useful tool for the study and treatment of biliary pathology. Ultrathin upper endoscopes allow direct peroral cholangioscopy (DPC but have some drawbacks. Objective: The aim of the study was to evaluate the success rate of DPC with an ultrathin endoscope using a balloon catheter to reach the biliary confluence. Material and methods: Prospective observational study. An ultrathin endoscope (Olympus XP180N, outer diameter 5.5 mm, working channel 2 mm was used. To access the biliary tree, free-hand technique was used. To reach the biliary confluence an intraductal balloon catheter (Olympus B5-2Q diameter 1.9 mm and a 0.025 inch guide wire was used. In all cases sphincterotomy and/or sphincteroplasty was performed. The success rate was defined as the percentage of cases in which the biliary confluence could be reached with the ultrathin endoscope. Results: Fifteen patients (8 men/7 women were included. Mean age was 77.7 ± 10.8 years (range 45-91. The indications for cholangioscopy were suspected bile duct stones (n = 9, electrohydraulic lithotripsy for the treatment of difficult choledocholithiasis (n = 5 and evaluation of biliary stricture (n = 1. Access to the bile duct was achieved in 14/15 cases (93.3 %. Biliary confluence was reached in 13/15 cases (86.7 %. One complication was observed in one patient (oxigen desaturation. Conclusions: DPC with an ultrathin endoscope can be done with the free-hand technique. Intraductal balloon-guided DPC allows full examination of the common bile duct in most cases.

  15. Functional restoration of the esophagus after peroral endoscopic myotomy for achalasia

    Science.gov (United States)

    Huh, Cheal Wung; Youn, Young Hoon; Chung, Hyunsoo; Lee, Yong Chan; Park, Hyojin

    2017-01-01

    Purpose Peroral endoscopic myotomy (POEM) is a new efficacious treatment option for achalasia. We propose to define “esophageal remodeling” as the functional restoration of the esophagus that involves decreased lower esophageal sphincter (LES) pressure, recovery of esophageal body peristalsis, and reduction of luminal diameter. The aim of this study was to investigate “esophageal remodeling” after POEM for achalasia. Materials and methods We analyzed data from a prospectively collected database of POEM subjects, which included preoperative and 2-month postoperative Eckardt symptom scores, and results from esophageal high resolution manometry (HRM) and barium esophagogram (BE). We recruited 23 patients (13 male; mean age: 53.9 years) whose preoperative and postoperative HRM and BE results were available, from among 30 patients with achalasia who underwent POEM at two institutions between July 2013 and December 2015. Results All patients achieved clinical treatment success (Eckardt score≤3). Partial recovery of esophageal body peristalsis was noted in 1/5 patients with type I (20%), 6/11 with type II (54.5%), and 7/7 with type III (100%) achalasia after POEM. Pan-esophageal pressurization disappeared after POEM in 10/11 type II achalasia patients. The average diameter of the esophageal body after POEM was significantly decreased in all types of achalasia. Conclusion POEM provided excellent clinical symptomatic relief and esophageal remodeling in terms of restoration of peristalsis and reduction in diameter of the esophageal body, especially in patients with type III achalasia. PMID:28542509

  16. Peroral endoscopic remyotomy for failed Heller myotomy: a prospective single-center study.

    Science.gov (United States)

    Zhou, P H; Li, Q L; Yao, L Q; Xu, M D; Chen, W F; Cai, M Y; Hu, J W; Li, L; Zhang, Y Q; Zhong, Y S; Ma, L L; Qin, W Z; Cui, Z

    2013-01-01

    Recurrence/persistence of symptoms occurs in approximately 20 % of patients after Heller myotomy for achalasia. Controversy exists regarding the therapy for patients in whom Heller myotomy has failed. The aim of the current study was to evaluate the efficacy and feasibility of peroral endoscopic myotomy (POEM), a new endoscopic myotomy technique, for patients with failed Heller myotomy. A total of 12 patients with recurrence/persistence of symptoms after Heller myotomy, as diagnosed by established methods and an Eckardt score of ≥ 4, were prospectively included. The primary outcome was symptom relief during follow-up, defined as an Eckardt score of ≤ 3. Secondary outcomes were procedure-related adverse events, lower esophageal sphincter (LES) pressure on manometry, reflux symptoms, and medication use before and after POEM. All 12 patients underwent successful POEM after a mean of 11.9 years (range 2 - 38 years) from the time of the primary Heller myotomy. No serious complications related to POEM were encountered. During a mean follow-up period of 10.4 months (range 5 - 14 months), treatment success was achieved in 11/12 patients (91.7 %; mean score pre- vs. post-treatment 9.2 vs. 1.3; P Heller myotomy resulting in short-term symptom relief in > 90 % of cases. Previous Heller myotomy may make subsequent endoscopic remyotomy more challenging, but does not prevent successful POEM. © Georg Thieme Verlag KG Stuttgart · New York.

  17. Peroral Endoscopic Myotomy in Children: First Experience With a New Triangular Knife.

    Science.gov (United States)

    Nabi, Zaheer; Ramchandani, Mohan; Chavan, Radhika; Tandan, Manu; Kalapala, Rakesh; Darisetty, Santosh; Reddy, Duvuur Nageshwar

    2018-01-01

    Peroral endoscopic myotomy (POEM) is a novel treatment modality for achalasia cardia. The procedure is technically challenging and time consuming. Recently, a new triangle tip knife (TTJ) has been introduced, which is equipped with water jet facility. In the present study, we analyzed the feasibility, safety, and efficacy of POEM in children with new triangle tip knife. We retrospectively evaluated the data of children (18 years or younger) who underwent POEM using TTJ knife at our institution. All POEM procedures were performed under general anesthesia in an endoscopy suite. Technical feasibility, safety, efficacy, and procedure duration were assessed. Ten children (4 boys, 6 girls) with mean age of 14.2 ± 2.74 (9-18) years, underwent POEM with TTJ knife. The subtypes of achalasia cardia were type I (4), type II (5), and type III (1). Two children had prior treatment with pneumatic balloon dilatation. POEM was performed via anterior route in majority of children (70%). Mean operating time was 47.6 ± 19.74 (30-98) minutes with no significant difference between anterior and posterior approaches to POEM (48.57 ± 24.01 vs 45.3 ± 3.51; P knife equipped with water jet technique. Integration of water jet reduces procedure duration and technical difficulty with POEM.

  18. [Peroral and transdermal application of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of regional musculoskeletal pain syndromes].

    Science.gov (United States)

    Hodinka, László; Bálint, Géza; Budai, Erika; Géher, Pál; Papp, Renáta; Somogyi, Péter; Szántó, Sándor; Vereckei, Edit

    2017-12-01

    In this review the available evidences regarding the most frequently applied medication (peroral and transdermal non-steroidal anti-inflammatory agents) for the most frequent musculoskeletal complaints (regional pain syndromes) have been collected for the appropriate medical professionals who are most frequently faced with these conditions (general practitioners, rheumatologists, orthopedics, occupational and sports medicine experts). The special population at risk (with repeated and high energy overuse because of occupational or sport activities) and the pathology of their syndromes are identified. Mode of action, pharmacological properties of the non-steroidal anti-inflammatory drugs and the unwanted effects of their application especially in infants and elderly are highlighted. Recommendations of the general and specific pain management guidelines have been selected and listed in the review. Orv Hetil. 2017; 158(Suppl. 3): 3-30.

  19. Peroral endoscopic myotomy: procedural complications and pain management for the perioperative clinician

    Science.gov (United States)

    Misra, Lopa; Fukami, Norio; Nikolic, Katarina; Trentman, Terrence L

    2017-01-01

    Achalasia refers to the lack of smooth muscle relaxation of the distal esophagus. Although nonsurgical treatments such as pneumatic dilatation of the distal esophagus and botulinum toxin injections have been performed, these procedures have limited duration. Similarly, surgical treatment with Heller myotomy is associated with complications. At our institution, we perform the peroral endoscopic myotomy (POEM) in qualified patients. Briefly, POEM involves endoscopic creation of a mid-esophageal submucosal bleb, creation of a submucosal tunnel with the endoscope, and then a distal myotomy, resulting in relaxation of the distal esophagus. The aim of our study is to document perioperative pain and associated pain management for our initial patients undergoing POEM and to review the literature for perioperative complications of this procedure. Therefore, anesthetic and pain management for our initial eleven patients undergoing POEM were reviewed. Patient demographics, pre-POEM pain medication history, perioperative pain medication requirements, and post-POEM pain scores were examined. We found post-POEM pain was usually in the mild–moderate range; a combination of medications was effective (opioids, nonsteroidal anti-inflammatory drugs, acetaminophen). Our literature search revealed a wide frequency range of complications such as pneumoperitoneum and subcutaneous emphysema, with rare serious events such as capnopericardium leading to cardiac arrest. In conclusion, our experience with POEM suggests pain and can be managed adequately with a combination of medications; the procedure appears to be safe and reasonable to perform in an outpatient endoscopy unit. PMID:28260955

  20. Per-Oral Endoscopic Myotomy Versus Laparoscopic Heller Myotomy for Achalasia

    Science.gov (United States)

    Zhang, Yuan; Wang, Hongjuan; Chen, Xingdong; Liu, Lan; Wang, Hongbo; Liu, Bin; Guo, Jianqiang; Jia, Hongying

    2016-01-01

    Abstract We aimed to assess the short-term outcomes of per-oral endoscopic myotomy (POEM) compared with laparoscopic Heller myotomy (LHM) for achalasia through a meta-analysis of nonrandomized comparative studies. We searched PubMed, Embase, Medline, Cochrane Library, and Google Scholar for studies that compared POEM and LHM for achalasia and were published between January 1, 2008 and December 31, 2014. The Methodological Index for Nonrandomized Studies (MINORS) was used to evaluate the quality of the studies. Random- and fixed-effects meta-analytical models were used, and between-study heterogeneity was assessed. Four nonrandomized comparative studies that included 317 patients (125 in the POEM group and 192 in the LHM group) met our research criteria and were assessed. There were no differences between the POEM and LHM groups in terms of sex, preoperative Eckhart score, length of myotomy, operation time, length of hospital stay, and complications. The patients in the POEM group were older than those in the LHM group (MD =2.81, 95% CI 0.27–5.35; P = 0.03) with high between-study homogeneity (χ2 = 1.96, df = 2, I2 = 0%; P = 0.38). The patients in the POEM group had a lower Eckardt score after surgery compared with those in the LHM group (MD = −0.30, 95% CI −0.42 to −0.18; P < 0.001) with high between-study homogeneity (χ2 = 0.00, df = 1, I2 = 0%; P = 1.00). The efficacy and safety of POEM appear to be comparable to those of LHM. Multicenter and randomized trials with larger sample size are needed to further compare the efficacy and safety of POEM and LHM for the treatment of achalasia. PMID:26871816

  1. Training in peroral endoscopic myotomy (POEM for esophageal achalasia

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    Eleftheriadis N

    2012-07-01

    Full Text Available Nicholas Eleftheriadis, Haruhiro Inoue, Haruo Ikeda, Manabu Onimaru, Akira Yoshida, Toshihisa Hosoya, Roberta Maselli, Shin-ei KudoDigestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, JapanAbstract: Peroral endoscopic myotomy (POEM has been developed in the context of natural orifice transluminal endoscopic surgery (NOTES as a minimally invasive endoscopic treatment for symptomatic esophageal achalasia, which is a chronic progressive benign disease with severe morbidity and difficult management. Since September 2008, POEM has been successfully performed in more than 200 consecutive patients with symptomatic achalasia at the Digestive Disease Center of Showa University, Northern Yokohama Hospital, Yokohama, Japan, with excellent short- and long-term results and absence of serious complications. International experience of POEM within clinical studies is also promising. According to these results, POEM is considered as a safe procedure that can be applied to all achalasia patients. However, the low incidence of achalasia (0.3%–1% per 100,000 population, in combination with the potential serious complications related to the technically demanding POEM procedure, has made training difficult. There is therefore an urgent need for an animal model for training to decrease the learning curve. Further, there are other ethical and training issues to address. The pig is the most appropriate animal model for training in POEM due to its anatomy being similar to that of humans. The porcine esophagus has the advantage of easy mobilization due to absence of tight junctions to surrounding organs. A non-survival porcine model would be a simple, inexpensive, and reproducible animal model for training in POEM, without the need for concern about complications. A possible training process might first involve observation of POEM performed by specialists, then training on non-survival and survival porcine models, followed by training in

  2. Double-Scope Peroral Endoscopic Myotomy (POEM for Esophageal Achalasia: The First Trial of a New Double-Scope POEM

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    Hee Jin Hong

    2016-07-01

    Full Text Available With the accumulation of clinical trials demonstrating its efficacy and safety, peroral endoscopic myotomy (POEM has emerged as a less invasive treatment option for esophageal achalasia compared with laparoscopic Heller myotomy. However, the difficulty in determining the exact extent of myotomy, a critical factor associated with the success and safety of the procedure, remains a limitation. Although the various endoscopic landmarks and ancillary techniques have been applied, none of these has been proven sufficient. As a solution for this limitation, the double-scope POEM technique with a second endoscope to assure the exact length of the submucosal tunnel has been applied since 2014. Before double-scope POEM was introduced, the second endoscope was applied only to confirm the accuracy of the procedure. In the present study, we performed double-scope POEM in the treatment of esophageal achalasia through a novel procedure of simultaneous application of the second endoscope to assist in the conventional POEM procedure.

  3. A multicenter international registry of redo per-oral endoscopic myotomy (POEM) after failed POEM.

    Science.gov (United States)

    Tyberg, Amy; Seewald, Stefan; Sharaiha, Reem Z; Martinez, Guadalupe; Desai, Amit P; Kumta, Nikhil A; Lambroza, Arnon; Sethi, Amrita; Reavis, Kevin M; DeRoche, Ketisha; Gaidhane, Monica; Talbot, Michael; Saxena, Payal; Zamarripa, Felipe; Barret, Maximilien; Eleftheriadis, Nicholas; Balassone, Valerio; Inoue, Haruhiro; Kahaleh, Michel

    2017-06-01

    Per-oral endoscopic myotomy (POEM) has become an accepted treatment for patients with achalasia. Despite its excellent efficacy rate of greater than 80%, a small percentage of patients remain symptomatic after the procedure. Limited data exist as to the best management for recurrence of symptoms after POEM. We present the first international, multicenter experience on the efficacy and safety of a repeat POEM in the management of achalasia. Patients who underwent a redo POEM from 15 centers in 9 countries were included in a dedicated registry. Technical success was defined as successful completion of a second myotomy. Clinical success was defined as an Eckardt score of less than or equal to 3 after the second myotomy. Adverse events including anesthesia-related, operative, and postoperative adverse events were recorded. Forty-six patients were included in the study. The average age was 49.3 ± 16.78 years. Twenty (45%) patients were male. The mean pre-redo-POEM Eckardt score was 4.3 ± 2.48. Technical success was achieved in 46 (100%) patients. Clinical success was achieved in 41 patients (85%). The average post-POEM Eckardt score was 1.64 ± 1.67, with a significant difference of 2.58 (P Heller should be considered. (Clinical trial registration number: NCT02162589.). Copyright © 2017 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

  4. Endoscopy versus radiology in post-procedural monitoring after peroral endoscopic myotomy (POEM).

    Science.gov (United States)

    Nast, Jan Friso; Berliner, Christoph; Rösch, Thomas; von Renteln, Daniel; Noder, Tania; Schachschal, Guido; Groth, Stefan; Ittrich, Harald; Kersten, Jan F; Adam, Gerhard; Werner, Yuki B

    2018-03-15

    The newly developed technique of peroral endoscopic myotomy (POEM) has been shown to be effective in several short- and mid-term studies. Limited information is available about the adequacy of immediate post-POEM monitoring tests. POEM was performed under general anesthesia in 228 patients (59.6% male, mean age 45.6 ± 15.5 years). Post-procedural checks comprised clinical and laboratory examination, and, during post-procedure days 1-5, endoscopy and-in the first 114 cases-radiologic examination using water-soluble contrast (1st group); the remaining patients underwent post-procedure controls without radiology (2nd group). Main outcome was value of endoscopic compared to radiologic control for recognition of early adverse events. In the first group, routine fluoroscopic contrast swallow suggested minor leakages at the mucosal entry site in two cases which was confirmed endoscopically in only one. Endoscopy revealed two minor entry site leakages and, in six additional cases, dislocated clips without leakage (overall 5.3%). All eight patients underwent reclipping and healed without clinical sequelae. In the 2nd group, endoscopy showed 5 clip dislocations (all reclipped) and one ischemic cardiac perforation in a patient with clinical deterioration on post-POEM day 1 who had to undergo surgery after confirmation of leakage by CT. Radiologic monitoring (contrast swallow) after POEM is not useful and can be omitted. Even routine endoscopic monitoring for detection and closure of minor defects of the mucosal entry site yields limited information with regards to final outcome; major complications are very rare and probably associated with clinical deterioration. Clinical Trials Gov Registration number of the main study: NCT01405417.

  5. Successful peroral endoscopic myotomy performed in Endoscopy Department as a radical, long-term treatment for esophageal achalasia – the Greek experience

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    Eleftheriadis N

    2017-02-01

    Full Text Available Nikolas Eleftheriadis,1,2 Eleni Damianos Eleftheriadou2 1Endoscopy Department, Gastroenterology Unit, Metropolitan Hospital Athens, 2Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece Introduction: Peroral endoscopic myotomy (POEM has been considered as a minimal-invasive, innovative technique for long-term treatment of all types of esophageal achalasia and other esophageal motility disorders.Patients and methods: We report on 20 consecutive Greek patients with manometrically proved esophageal achalasia (14 patients with type I, 4 with type II, 2 with type III, and 4 with sigmoid esophagus, with an age range of 32–92 years, mean age 59 years, 12 males, successfully treated by POEM from 2013 to 2015. The Eckardt score was 7–12 (type III. Seventeen (85% POEM procedures were performed in the Endoscopy Department, according to a previous study. During POEM, CO2 insufflation was mandatory, while the Triangle Tip knife was the only knife used in all procedures. Eckardt score, esophagogram and manometry before and after performing POEM were used for evaluation of our results. The follow-up period was 6 months to 3 years.Results: Selective circular myotomy, 10–13 cm in length, was successfully completed in all patients without severe acute or late complications. Three patients (15% showed moderate pneumomediastinum and pneumoperitoneum, which was successfully managed by abdominal needle drainage during the procedure. One patient showed mild pleural collection, and in one patient the clip–endoloop technique was used to successfully close the mucosal entry after the completion of POEM. The outcome was uneventful without any further clinical consequences. No other short- or long-term serious complications were reported. Patients were discharged after 1–3 days of hospitalization. Six months to 3 years after the POEM procedure, all patients were alive; the majority (90% had complete clinical improvement, while two patients

  6. Long-term outcome of peroral endoscopic myotomy for esophageal achalasia in patients with previous Heller myotomy.

    Science.gov (United States)

    Kristensen, Helle Ø; Kirkegård, Jakob; Kjær, Daniel Willy; Mortensen, Frank Viborg; Kunda, Rastislav; Bjerregaard, Niels Christian

    2017-06-01

    Peroral endoscopic myotomy (POEM) is an emerging procedure in the treatment of esophageal achalasia, a primary motility disorder. However, the long-term outcome of POEM in patients, who have previously undergone a Heller myotomy, is unknown. Using a local database, we identified patients with esophageal achalasia, who underwent POEM. We compared patients with a previous Heller myotomy to those, who had received none or only non-surgical therapy prior to the POEM procedure. We conducted follow-up examinations at 3, 12, and 24 months following the procedure. We included 66 consecutive patients undergoing POEM for achalasia, of which 14 (21.2 %) had undergone a prior Heller myotomy. In both groups, the preoperative Eckardt score was 7. Postoperatively, the non-Heller group experienced a more pronounced symptom relief at both 3-, 12-, and 24-month follow-up compared with the Heller group, and there was a tendency for the effect of POEM to reduce over time. We suggest that there is a correlation between preoperative measurements of gastroesophageal sphincter pressures and the chance of a successful POEM. POEM has a place in the treatment of esophageal achalasia in patients with a prior Heller myotomy and persistent symptoms as it is a safe procedure with acceptable long-term results.

  7. Peroral endoscopic myotomy: procedural complications and pain management for the perioperative clinician

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    Misra L

    2017-02-01

    Full Text Available Lopa Misra,1 Norio Fukami,2 Katarina Nikolic,1 Terrence L Trentman1 1Department of Anesthesiology, 2Division of Gastroenterology and Hepatology, Mayo Clinic Arizona, Phoenix, AZ, USA Abstract: Achalasia refers to the lack of smooth muscle relaxation of the distal esophagus. Although nonsurgical treatments such as pneumatic dilatation of the distal esophagus and botulinum toxin injections have been performed, these procedures have limited duration. Similarly, surgical treatment with Heller myotomy is associated with complications. At our institution, we perform the peroral endoscopic myotomy (POEM in qualified patients. Briefly, POEM involves endoscopic creation of a mid-esophageal submucosal bleb, creation of a submucosal tunnel with the endoscope, and then a distal myotomy, resulting in relaxation of the distal esophagus. The aim of our study is to document perioperative pain and associated pain management for our initial patients undergoing POEM and to review the literature for perioperative complications of this procedure. Therefore, anesthetic and pain management for our initial eleven patients undergoing POEM were reviewed. Patient demographics, pre-POEM pain medication history, perioperative pain medication requirements, and post-POEM pain scores were examined. We found post-POEM pain was usually in the mild–moderate range; a combination of medications was effective (opioids, nonsteroidal anti-inflammatory drugs, acetaminophen. Our literature search revealed a wide frequency range of complications such as pneumoperitoneum and subcutaneous emphysema, with rare serious events such as capnopericardium leading to cardiac arrest. In conclusion, our experience with POEM suggests pain and can be managed adequately with a combination of medications; the procedure appears to be safe and reasonable to perform in an outpatient endoscopy unit. Keywords: pain management, retrospective study, combination of medicines, perioperative, endoscopy

  8. Selenium, cadmium and diazinon insecticide in tissues of rats after peroral exposure

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    Róbert Toman

    2017-01-01

    Full Text Available The concentrations of selenium (Se, cadmium (Cd and diazinon (DZN in selected tissues of rats after an oral administration in various combinations were analyzed. Male rats were orally dosed with diazinon (40 mg.L-1, diazinon (40 mg.L-1 +selenium (5 mg.L-1, diazinon (40 mg.L-1 +cadmium (30 mg.L-1, and diazinon (40 mg.L-1 +selenium (5 mg.L-1 +cadmium (30 mg.L-1 in drinking water. After 90 days of per oral administration of compounds, the samples of liver, kidney, muscle tissue (m. quadriceps femoris, and adipose tissue were collected. The content of DZN was analyzed using Gas Chromatography - Mass Spectrometry (GC-MS, Cd was analyzed using an Electrothermal Atomic Absorption Spectrometry (ETAAS and Se using a Hydride Generation Atomic Absorption Spectrometry (HG-AAS methods. Cadmium significantly increased in liver and kidney after DZN +Cd and DZN +Se +Cd administration. Se significantly increased in liver of DZN +Se, DZN +Se +Cd and DZN +Cd exposed rats, in kidney of DZN +Se and DZN +Se +Cd and DZN +Cd, and in muscle of DZN +Se +Cd group. Highest DZN content was found in the adipose tissue in DZN, DZN +Cd and DZN +Se +Cd but not in combined exposure with Se. Anyway, the differences between the control and experimental groups were not significant. The results indicate that cadmium and selenium accumulate mainly in liver, kidney and selenium also in muscle after p.o. administration but diazinon concentrations increases were not signifcant. The co-administration of diazinon, Se and Cd affects the content of these compounds in the organism and the accumulation rate depends on the combination of administered compounds. Diazinon and cadmium could contribute to the selenium redistribution in the organism after the peroral intake.

  9. Miotomía endoscópica peroral, experiencia in vivo: imprescindible para desarrollo de la técnica en humanos

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    A. Peñaloza-Ramírez

    2018-04-01

    humanos. Abstract: Introduction and objectives: Achalasia is the most widely studied esophageal motility disorder. No treatment has achieved completely satisfactory results. The laparoscopic Heller esophagomyotomy is currently the most accepted technique. With the advent of minimally invasive surgery, the appearance of peroral endoscopic myotomy (POEM has promising results. The primary aim of our study was to perform peroral endoscopic esophagomyotomy in animal experimentation models to perfect the technique and later apply it to humans. The secondary aims were to evaluate the intraoperative and postoperative complications and to describe the anatomopathologic findings. Materials and methods: An experimental study was conducted on 8 live porcine models that were followed for 30 days to identify postoperative complications. Necropsy was then performed to evaluate the histopathologic findings. The international requirements and regulations for animal experimentation were met. Results: The technique was carried out in all the models. There was one intraoperative death. Pneumothorax was observed in 50% of the units in experimentation and subcutaneous cervical emphysema in 75%, with no significant clinical repercussions. Histologic muscle layer (myotomy involvement was above the gastroesophageal junction in 87% of the cases and below it in 25%. Conclusion: Peroral endoscopic esophagomyotomy is a feasible, albeit complex, procedure that requires advanced training, and thus should be performed in highly specialized centers. Specific skills in advanced therapeutic endoscopic procedures of this type must continue to be developed through continuing education (ideally in in vivo models, to then be performed on humans. Palabras clave: Esofagomiotomía endoscópica, Modelos in vivo, Acalasia, Keywords: Endoscopic esophagomyotomy, In vivo models, Achalasia

  10. Per-oral endoscopic myotomy (POEM: a new endoscopic treatment for achalasia

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    Pablo Miranda-García

    Full Text Available Background/aims: Per-oral endoscopic myotomy (POEM is a new minimally invasive technique to treat achalasia. Methods: We performed a review of the literature of POEM with a special focus on technical details and the results obtained with this technique in patients with achalasia and other esophageal motility disorders. Results: Thousands of POEM procedures have been performed worldwide since its introduction in 2008. The procedure is based on the creation of a mucosal entry point in the proximal esophagus to reach the cardia through a submucosal tunnel and then perform a myotomy of the muscular layers of the cardia, esophagogastric junction and distal esophagus, as performed in a Heller myotomy. The clinical remission rate ranges from 82 to 100%. Although no randomized studies exist and available data are from single-center studies, no differences have been found between laparoscopic Heller myotomy (LHM and POEM in terms of perioperative outcomes, short-term outcomes (12 months and long-term outcomes (up to three years. Procedure time and length of hospital stay were lower for POEM. Post-POEM reflux is a concern, and controversial data have been reported compared to LHM. The technique is safe, with no reported deaths related to the procedure and an adverse event rate comparable to surgery. Potential complications include bleeding, perforation, aspiration and insufflation-related adverse events. Thus, this is a complex technique that needs specific training even in expert hands. The indication for this procedure is widening and other motor hypercontractil esophageal disorders have been treated by POEM with promising results. POEM can be performed in complicated situations such as in pediatric patients, sigmoid achalasia or after failure of previous treatments. Conclusions: POEM is an effective treatment for achalasia and is a promising tool for other motor esophageal disorders. It is a safe procedure but, due to its technical difficulty and

  11. Per-oral endoscopic myotomy (POEM): a new endoscopic treatment for achalasia.

    Science.gov (United States)

    Miranda García, Pablo; Casals Seoane, Fernando; Gonzalez, Jean-Michel; Barthet, Marc; Santander Vaquero, Cecilio

    2017-10-01

    Per-oral endoscopic myotomy (POEM) is a new minimally invasive technique to treat achalasia. We performed a review of the literature of POEM with a special focus on technical details and the results obtained with this technique in patients with achalasia and other esophageal motility disorders. Thousands of POEM procedures have been performed worldwide since its introduction in 2008. The procedure is based on the creation of a mucosal entry point in the proximal esophagus to reach the cardia through a submucosal tunnel and then perform a myotomy of the muscular layers of the cardia, esophagogastric junction and distal esophagus, as performed in a Heller myotomy. The clinical remission rate ranges from 82 to 100%. Although no randomized studies exist and available data are from single-center studies, no differences have been found between laparoscopic Heller myotomy (LHM) and POEM in terms of perioperative outcomes, short-term outcomes (12 months) and long-term outcomes (up to three years). Procedure time and length of hospital stay were lower for POEM. Post-POEM reflux is a concern, and controversial data have been reported compared to LHM. The technique is safe, with no reported deaths related to the procedure and an adverse event rate comparable to surgery. Potential complications include bleeding, perforation, aspiration and insufflation-related adverse events. Thus, this is a complex technique that needs specific training even in expert hands. The indication for this procedure is widening and other motor hypercontractil esophageal disorders have been treated by POEM with promising results. POEM can be performed in complicated situations such as in pediatric patients, sigmoid achalasia or after failure of previous treatments. POEM is an effective treatment for achalasia and is a promising tool for other motor esophageal disorders. It is a safe procedure but, due to its technical difficulty and possible associated complications, the procedure should be performed

  12. Ling classification describes endoscopic progressive process of achalasia and successful peroral endoscopy myotomy prevents endoscopic progression of achalasia.

    Science.gov (United States)

    Zhang, Wen-Gang; Linghu, En-Qiang; Chai, Ning-Li; Li, Hui-Kai

    2017-05-14

    To verify the hypothesis that the Ling classification describes the endoscopic progressive process of achalasia and determine the ability of successful peroral endoscopic myotomy (POEM) to prevent endoscopic progression of achalasia. We retrospectively reviewed the endoscopic findings, symptom duration, and manometric data in patients with achalasia. A total of 359 patients (197 women, 162 men) with a mean age of 42.1 years (range, 12-75 years) were evaluated. Symptom duration ranged from 2 to 360 mo, with a median of 36 mo. Patients were classified with Ling type I ( n = 119), IIa ( n = 106), IIb ( n = 60), IIc ( n = 60), or III ( n = 14), according to the Ling classification. Of the 359 patients, 349 underwent POEM, among whom 21 had an endoscopic follow-up for more than 2 years. Pre-treatment and post-treatment Ling classifications of these 21 patients were compared. Symptom duration increased significantly with increasing Ling classification (from I to III) ( P achalasia and may be able to serve as an endoscopic assessment criterion for achalasia. Successful POEM (Eckardt score ≤ 3) seems to have the ability to prevent endoscopic evolvement of achalasia. However, studies with larger populations are warranted to confirm our findings.

  13. Per-oral endoscopic myotomy for achalasia. Are results comparable to laparoscopic Heller myotomy?

    Science.gov (United States)

    Kumagai, Koshi; Tsai, Jon A; Thorell, Anders; Lundell, Lars; Håkanson, Bengt

    2015-05-01

    Per-oral endoscopic myotomy (POEM) has recently been introduced as a minimal invasive alternative to conventional treatment for achalasia. This study aimed to clarify the feasibility and the short-term clinical efficacy of POEM as compared to laparoscopic Heller myotomy (LHM). Treatment outcomes were prospectively recorded and compared between the procedures in a nonrandomized fashion. Reduction rate (RR) in timed barium esophagogram (TBE) was calculated at 1, 2 and 5 min after barium ingestion as: RR = 1- postoperative barium height/preoperative barium height. Risk factors for treatment failure defined as the proportion of patients with RR <0.5 (1 min) and gastroesophageal reflux (GER) after POEM were analyzed. Forty-two consecutive patients who underwent POEM were compared to 41 patients who had a LHM during the immediate time period prior to the introduction of POEM. Ninety percent of the cases reported complete symptom relief after POEM. The percentage of esophageal emptying and RR in TBE improved dramatically by both procedures without significant difference. A longer operation time (odds ratio [OR] 32.80, 95%CI 2.99-359.82, p = 0.004) and younger age (OR 26.81, 95%CI 2.09-344.03, p = 0.012) were the independent predictors of treatment failure after POEM. GER was observed in seven patients where previous dilatation (OR 8.59, 95%CI 1.16-63.45, p = 0.035) and higher body mass index (OR 8.69, 95%CI 1.13-66.63, p = 0.037) were the independent predictors for symptomatic GER after POEM. POEM seems to be a safe and effective treatment option for achalasia in the short-term perspective; an effect well comparable to LHM.

  14. Comparison of conventional versus Hybrid knife peroral endoscopic myotomy methods for esophageal achalasia: a case-control study.

    Science.gov (United States)

    Tang, Xiaowei; Gong, Wei; Deng, Zhiliang; Zhou, Jieqiong; Ren, Yutang; Zhang, Qiang; Chen, Zhenyu; Jiang, Bo

    2016-01-01

    Peroral endoscopic myotomy (POEM) has been developed to treat achalasia as a novel less invasive modality. We aimed to compare the efficacy and safety of conventional knife versus Hybrid knife (HK) during POEM procedure. Between June 2012 and July 2014, 31 patients underwent POEM using HK in our department (HK group), and 36 patients underwent POEM using conventional method (injection needle and triangular tip [TT] knife, TT group). Procedure-related parameters, symptom relief, adverse events were compared between two groups. There were no significant differences in the age, sex and other baseline characteristics between the two groups. The mean procedural time was significantly shorter in HK group than TT group (53.0 ± 17.2 vs. 67.6 ± 28.4 min, p = 0.015). The mean frequency of devices exchange was 4.7 ± 1.7 in HK group and 10.9 ± 1.8 in TT group (p = 0.000). No serious adverse events occurred postoperatively in both groups. At one-year follow-up, a total of 94% treatment success was achieved in all patients (93.5% in HK group and 94.4% in TT group, p = 0.877). HK in POEM can shorten the procedural time, and achieve similar treatment success compared to conventional TT knife.

  15. Comparison of outcomes of laparoscopic Heller myotomy versus per-oral endoscopic myotomy for management of achalasia.

    Science.gov (United States)

    Leeds, Steven G; Burdick, J S; Ogola, Gerald O; Ontiveros, Estrellita

    2017-10-01

    Achalasia is a rare disorder that has several treatment options. The gold standard of treatment is a surgical myotomy called a laparoscopic Heller myotomy (LHM). More recently, an endoscopic myotomy has become an option as well, called per-oral endoscopic myotomy (POEM). An achalasia registry was queried for patients undergoing either LHM or POEM at Baylor University Medical Center at Dallas. Patient demographics, preoperative and postoperative data points, and Eckardt scores were collected. The patients were further stratified into their follow-up intervals, immediate postoperative and long-term follow-up, to assess surgical success. A subset analysis was done for success of treatment for patients who had redo surgery versus those undergoing the procedure for the first time. There were 12 patients in the POEM group and 11 patients in the LHM group. Both groups demonstrated mean lower esophageal sphincter pressures with failure to relax. Procedure length and hospital length of stay were similar between the two groups. There were three adverse events in each group, but none altered the patient's postoperative clinical course. Eckardt scores, used to assess success of the surgery, were 82% for POEM patients and 66% for LHM patients after 6 months. The outcomes for POEM and LHM in our early experience are similar to those reported in the literature for high-volume centers managing achalasia.

  16. Retrograde gastroesophageal intussusception after peroral endoscopic myotomy in a patient with achalasia cardia: A case report.

    Science.gov (United States)

    Khan, Samiullah; Su, Shuai; Jiang, Kui; Wang, Bang-Mao

    2018-01-01

    Retrograde gastroesophageal intussusception (RGEI) is a relatively rare gastrointestinal (GI) disorder in which a portion of the stomach wall invaginates into the esophagus. More recently, peroral endoscopic myotomy (POEM) has emerged as an endoscopic alternative to surgical myotomy for achalasia, and, to the best of our knowledge, our case is the first RGEI after POEM to be reported. A 22-year-old male was presented with a history of vomiting, intractable retching and hematemesis for 3 days. He had a history of achalasia and underwent POEM 3 years ago caused by symptoms of severe dysphagia to solid and liquid. Initially, the patient was diagnosed with a blood-filled esophagus, and the mid esophagus was occluded with a ball-like mass, however, the final diagnosis of RGEI was made by thoracotomy. A therapeutic strategy of conservative treatment and left transthoracic surgery were applied. The surgery and post operative course were uneventful, and he remained asymptomatic 1 year after operation. POEM is a reliable and minimally invasive endoscopic method for esophageal achalasia. Early recognition and severity of RGEI are essential to decrease the unwanted complications. Upper GI series, esophagogastroduodenoscopy and computed tomography scan are helpful for diagnostic purposes of RGEI. Conservative treatment, endoscopic intervention, and surgery are the mainstay of treatments for RGEI. Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

  17. Peroral endoscopic myotomy versus pneumatic dilation for achalasia in patients aged ≥ 65 years

    Directory of Open Access Journals (Sweden)

    Xuehong Wang

    Full Text Available Background and aim: Both peroral endoscopic myotomy (POEM and pneumatic dilation (PD has proved to be effective for treating achalasia in patients aged ≥ 65 years. However little is known about the comparison between POEM and PD. The aim of the study was to compare the safety and efficacy of POEM and PD for the treatment of achalasia in these patients. Methods: We retrospectively reviewed the medical records of patients aged 65 years-old or more who received POEM or PD for the treatment of achalasia at our hospital from January 2010 to December 2015, they were divided into the POEM group and the PD group. Demographics and data about safety and efficacy were collected retrospectively and compared between the two groups. Results: A total of 31 patients were enrolled, and 21 of them received POEM, while the other 10 received PD. The treatment success (Eckardt score ≤ 3 rate of POEM and PD at 3, 6, 12, 24 and 36 months after the treatment were comparable (p > 0.05. Treatment failure was noticed in 3 cases, 1 of them was in the POEM group and the other 2 in the PD group, there was no significant difference (p > 0.05. Multivariate analysis showed that sigmoid-type achalasia was a predictive factor of treatment failure. No severe complications were observed during operation and periodical follow-up. Conclusion: Short-term and intermediate efficacy of POEM and PD for treating achalasia in patients aged ≥ 65 years was comparable. A large scale, randomized study with long-term follow-up is necessary in order to make a definitive conclusion.

  18. Outcome of peroral endoscopic myotomy in achalasia cardia: Experience with a new triangular knife.

    Science.gov (United States)

    Nabi, Zaheer; Ramchandani, Mohan; Chavan, Radhika; Kalapala, Rakesh; Darisetty, Santosh; Reddy, D Nageshwar

    2018-01-01

    Peroral endoscopic myotomy (POEM) is a technically demanding procedure. Recently, a new triangular knife with integrated water jet function (TTJ) has been introduced. The present study was aimed to analyze and compare the operating time, efficacy, and adverse events (AEs) between the conventional (TT knife) and new knife (TTJ). All patients with achalasia cardia (AC) who underwent POEM between August 2015 and November 2016 were analyzed retrospectively. Operating time (OT), technical success, and AEs were assessed and compared between TT and TTJ knife. A total of 193 patients with AC underwent POEM during the specified period. Both groups had equivalent number of different subtypes of AC (I, II, and III). There was no difference in technical success between the two groups (TT, 99% vs TT, 98.9%). OT was significantly less in the TTJ group as compared to TT group (53.8 ± 15.2 vs 66.26 ± 19.2; P = 0.0001). On subanalysis, OT taken for submucosal tunneling was significantly less with TTJ knife (34.6 ± 10.1 vs 45.83 ± 14.80), whereas OT was similar for myotomy and clipping in both the groups. Significantly fewer use of coagulation forceps and exchanges of accessories were required in TTJ knife group (2.92 ± 1.77 vs 10.5 ± 3.58; P = 0.0001). There were no major AEs. Minor AEs were noted in 21.5% and 31% of patients in TTJ and TT knife groups, respectively. New triangular knife reduces procedure time and technical difficulty with POEM. POEM is an efficacious treatment for achalasia and can be safely executed in an endoscopy unit.

  19. Human rhinovirus in experimental infection after peroral Lactobacillus rhamnosus GG consumption, a pilot study.

    Science.gov (United States)

    Tapiovaara, Laura; Kumpu, Minna; Mäkivuokko, Harri; Waris, Matti; Korpela, Riitta; Pitkäranta, Anne; Winther, Birgit

    2016-08-01

    Data has emerged on possible beneficial effects of probiotics in respiratory tract viral infections, but it is unclear if the promising positive effects evidenced are due to a reduced viral load during infections. The aims of this work were to investigate the effect of peroral probiotic Lactobacillus rhamnosus GG (American Type Culture Collection [ATCC], Accession No. 53103) consumption on human rhinovirus (HRV) load in nasopharyngeal lavage samples in experimental HRV infection, and to correlate viral load to clinical symptoms. Intranasal HRV A39 inoculation was performed on 59 adults, who had consumed juice enriched with live or heat-inactivated L. rhamnosus GG or control juice for 3 weeks prior to inoculation in a randomized, controlled, pilot trial setting. Nasopharyngeal lavage samples and symptom data were analyzed on day 0 before inoculation, and on days 2 and 5. Samples were subjected to quantitative HRV detection by polymerase chain reaction (PCR). Before inoculation 9 of 59 (15%) samples presented with another HRV strain than the studied A39. There was a tendency toward the lowest HRV loads in the L. rhamnosus GG groups and the highest in placebo group (log10 copies/mL, 95% confidence interval [CI], 6.20 [5.18 to 7.40] in live, 6.30 [4.91 to 7.08] in inactivated L. rhamnosus GG, and 7.25 [5.81 to 7.52] in placebo group, p = 0.57 in day 2) in the wild-type excluded population. The HRV load positively correlated with the symptom scores on days 2 and 5 (correlation coefficient 0.61 [p rhamnosus GG when compared to placebo. HRV load positively correlated with the total symptom scores. © 2016 ARS-AAOA, LLC.

  20. Outcome of Peroral Endoscopic Myotomy (POEM) for Treating Achalasia Compared With Laparoscopic Heller Myotomy (LHM).

    Science.gov (United States)

    Peng, Lijun; Tian, Shuni; Du, Chao; Yuan, Ziying; Guo, Mingxiao; Lu, Lin

    2017-02-01

    Peroral endoscopic myotomy (POEM) is an emerging endoscopic treatment for achalasia and the long-term efficacy of POEM remains to be evaluated. This study compared the outcomes of POEM with that of the standard laparoscopic Heller myotomy (LHM) for achalasia. Achalasia patients treated by POEM or LHM were retrospectively analyzed, with a minimum postoperative follow-up of 3 years. Perioperative outcomes and long-term outcomes including treatment success (Eckardt score ≤3), occurrence of gastroesophageal reflux disease (GERD) (GerdQ score ≥9) and quality of life (36-item short form) were compared. Thirteen patients who underwent POEM were compared with 18 patients who received LHM. These patients were similar in age, sex, symptoms duration, Eckardt score, and previous therapy (all P>0.05). Mean myotomy lengths were similar (P=0.73). Operation time was shorter in the POEM group (P=0.001). One patient (7.7%) developed pneumothorax after POEM and 1 patient (5.6%) experienced postoperative infection after LHM (P=1.00). Treatment success was achieved in 83.3% (9/12) of POEM patients and 80.0% (12/15) of LHM patients (P=1.00). Both POEM and LHM significantly reduced Eckardt score (both P=0.00). GERD rate was similar (8.3% vs. 6.7%, P=1.00). There was no difference in all aspects of quality of life between the 2 groups. Long-term outcomes indicate that POEM is an effective treatment that is comparable with LHM. More data of randomized trials comparing POEM with LHM will enrich the existing evidence.

  1. Salg og markedsføring af brugskunst i EU

    DEFF Research Database (Denmark)

    Rørdam, Mette Ohm

    2012-01-01

    Brugskunst kan i Danmark beskyttes efter reglerne i ophavsretsloven i indtil 70 år efter ophavsmandens død. I England beskyttes brugskunst kun i 25 år efter designretlige regler. Derfor kan der i England lovligt produceres og sælges brugskunst, der er ophavsretlig beskyttet i Danmark, uden aftale...

  2. Analysis of the learning curve for peroral endoscopic myotomy for esophageal achalasia: Single-center, two-operator experience.

    Science.gov (United States)

    Lv, Houning; Zhao, Ningning; Zheng, Zhongqing; Wang, Tao; Yang, Fang; Jiang, Xihui; Lin, Lin; Sun, Chao; Wang, Bangmao

    2017-05-01

    Peroral endoscopic myotomy (POEM) has emerged as an advanced technique for the treatment of achalasia, and defining the learning curve is mandatory. From August 2011 to June 2014, two operators in our institution (A&B) carried out POEM on 35 and 33 consecutive patients, respectively. Moving average and cumulative sum (CUSUM) methods were used to analyze the POEM learning curve for corrected operative time (cOT), referring to duration of per centimeter myotomy. Additionally, perioperative outcomes were compared among distinct learning curve phases. Using the moving average method, cOT reached a plateau at the 29th case and at the 24th case for operators A and B, respectively. CUSUM analysis identified three phases: initial learning period (Phase 1), efficiency period (Phase 2) and mastery period (Phase 3). The relatively smooth state in the CUSUM graph occurred at the 26th case and at the 24th case for operators A and B, respectively. Mean cOT of distinct phases for operator A were 8.32, 5.20 and 3.97 min, whereas they were 5.99, 3.06 and 3.75 min for operator B, respectively. Eckardt score and lower esophageal sphincter pressure significantly decreased during the 1-year follow-up period. Data were comparable regarding patient characteristics and perioperative outcomes. This single-center study demonstrated that expert endoscopists with experience in esophageal endoscopic submucosal dissection reached a plateau in learning of POEM after approximately 25 cases. © 2016 Japan Gastroenterological Endoscopy Society.

  3. Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function.

    Science.gov (United States)

    Sanaka, Madhusudhan R; Hayat, Umar; Thota, Prashanthi N; Jegadeesan, Ramprasad; Ray, Monica; Gabbard, Scott L; Wadhwa, Neha; Lopez, Rocio; Baker, Mark E; Murthy, Sudish; Raja, Siva

    2016-05-28

    To assess and compare the esophageal function after peroral endoscopic myotomy (POEM) vs other conventional treatments in achalasia. Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy (LHM) or pneumatic dilation (PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow (TBE) and high-resolution esophageal manometry (HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo post-treatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter (LES) pressures and LES-integrated relaxation pressures (IRP). Data are presented as mean ± SD, median [25(th), 75(th) percentiles] or frequency (percent). Analysis of variance, Kruskal-Wallis test, Pearsons χ(2) test and Fishers Exact tests were used for analysis. A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older (55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM (29.1 ± 5.9 kg/m(2) vs 26 ± 5.1 kg/m(2), P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group (72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups (P = 0.01 to P 0.05). POEM, PD and LHM were all effective in improving esophageal function in achalasia at short-term. There was no difference in efficacy between the three treatments.

  4. Effekten af udvidet periodisk syn på person- og varebiler

    DEFF Research Database (Denmark)

    Bernhoft, Inger Marie; Pilegaard, Ninette

    Dette notat har til formål at gennemføre en beregning af costs og benefits af udvidet periodisk syn af person- og varebiler i Danmark, under forudsætning af der gennemføres ét syn af per-son- og varebiler efter fire år, derefter ét syn efter to år og derefter én gang årligt (4,2,1,1…), som...... skulle være efter fire år, derefter efter to år, derefter efter to år igen og derefter årligt (4,2,2,1,1…). Dvs. at der i vores basisscenarie vil være ét ekstra syn (ved 7. år) i forhold til ’Autofore-rapportens’ ba-sis-scenarie. Dog udføres i ’Autofore-rapporten’ også følsomhedsberegninger...

  5. Efficacy and Safety of Peroral Endoscopic Myotomy for Treatment of Achalasia After Failed Heller Myotomy.

    Science.gov (United States)

    Ngamruengphong, Saowanee; Inoue, Haruhiro; Ujiki, Michael B; Patel, Lava Y; Bapaye, Amol; Desai, Pankaj N; Dorwat, Shivangi; Nakamura, Jun; Hata, Yoshitaka; Balassone, Valerio; Onimaru, Manabu; Ponchon, Thierry; Pioche, Mathieu; Roman, Sabine; Rivory, Jérôme; Mion, François; Garros, Aurélien; Draganov, Peter V; Perbtani, Yaseen; Abbas, Ali; Pannu, Davinderbir; Yang, Dennis; Perretta, Silvana; Romanelli, John; Desilets, David; Hayee, Bu; Haji, Amyn; Hajiyeva, Gulara; Ismail, Amr; Chen, Yen-I; Bukhari, Majidah; Haito-Chavez, Yamile; Kumbhari, Vivek; Saxena, Payal; Talbot, Michael; Chiu, Philip Wai-Yan; Yip, Hon-Chi; Wong, Vivien Wai-Yin; Hernaez, Ruben; Maselli, Roberta; Repici, Alessandro; Khashab, Mouen A

    2017-10-01

    In patients with persistent symptoms after Heller myotomy (HM), treatment options include repeat HM, pneumatic dilation, or peroral endoscopic myotomy (POEM). We evaluated the efficacy and safety of POEM in patients with achalasia with prior HM vs without prior HM. We conducted a retrospective cohort study of 180 patients with achalasia who underwent POEM at 13 tertiary centers worldwide, from December 2009 through September 2015. Patients were divided into 2 groups: those with prior HM (HM group, exposure; n = 90) and those without prior HM (non-HM group; n = 90). Clinical response was defined by a decrease in Eckardt scores to 3 or less. Adverse events were graded according to criteria set by the American Society for Gastrointestinal Endoscopy. Technical success, clinical success, and rates of adverse events were compared between groups. Patients were followed up for a median of 8.5 months. POEM was technically successful in 98% of patients in the HM group and in 100% of patients in the non-HM group (P = .49). A significantly lower proportion of patients in the HM group had a clinical response to POEM (81%) than in the non-HM group (94%; P = .01). There were no significant differences in rates of adverse events between the groups (8% in the HM group vs 13% in the non-HM group; P = .23). Symptomatic reflux and reflux esophagitis after POEM were comparable between groups. POEM is safe and effective for patients with achalasia who were not treated successfully by prior HM. Although the rate of clinical success in patients with prior HM is lower than in those without prior HM, the safety profile of POEM is comparable between groups. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

  6. Two-Person Technique of Peroral Endoscopic Myotomy for Achalasia with an Advanced Endoscopist and a Thoracic Surgeon: Initial Experience

    Directory of Open Access Journals (Sweden)

    Madhusudhan R. Sanaka

    2016-01-01

    Full Text Available Background and Aims. We initiated peroral endoscopic myotomy (POEM utilizing a two-person technique with combination of an advanced endoscopist and a thoracic surgeon with complementary skills. Our aim was to determine the feasibility and outcomes in initial 20 patients. Methods. In this observational study, main outcomes measured were therapeutic success in relieving symptoms (Eckardt score < 3, decrease in lower esophageal sphincter (LES pressures, improvement in emptying on timed barium esophagogram (TBE, and complications. Results. POEM was successful in all 20 patients with a mean operative time of 140.1+32.9 minutes. Eckardt symptom scores decreased significantly at two-month follow-up (6.4+2.9 versus 0.25+0.45, p<0.001. Both basal and residual LES pressures decreased significantly (28.2+14.1 mmHg versus 12.8+6.3 and 22.4+11.3 versus 6.3+3.4 mmHg, p=0.025 and <0.001, resp.. Barium column height at 5 minutes on TBE reduced from 6.8+4.9 cm to 2.3+2.9 cm (p=0.05. Two patients (10% had mucosal perforations and one had delayed bleeding (5%. Conclusions. Two-person technique of POEM with combination of an advanced endoscopist and a thoracic surgeon is highly successful with low risk of complications.

  7. Peroral endoscopic myotomy achieves similar clinical response but incurs lesser charges compared to robotic heller myotomy.

    Science.gov (United States)

    Khashab, Mouen A; Kumbhari, Vivek; Tieu, Alan H; El Zein, Mohamad H; Ismail, Amr; Ngamruengphong, Saowanee; Singh, Vikesh K; Kalloo, Anthony N; Clarke, John O; Stein, Ellen M

    2017-01-01

    Several uncontrolled studies comparing peroral endoscopic myotomy (POEM) and Heller myotomy have demonstrated equivalent short-term efficacy and safety. However, no data exists rergarding the cost of POEM and how it compares to that of robotic Heller myotomy (RHM). The primary aim of this study was to compare the inpatient charges incurred in patients who underwent POEM or RHM for the treatment of achalasia. A retrospective single center review was conducted among 52 consecutive POEM patients (2012-2014) and 52 consecutive RHM patients (2009-2014). All RHM procedures included a Toupet fundoplication and were performed via a transabdominal approach. All POEM procedures were performed by a gastroenterologist in the endoscopy unit. Clinical response was defined by improvement of symptoms and decrease in Eckardt stage to ≤I. All procedural and facility charges were obtained from review of the hospital finance records. There was no difference between POEM and RHM with regards to age, gender, symptom duration, achalasia subtype, manometry findings, or Eckardt symptom stage. There was no significant difference in the rate of adverse events (19.2% vs 9.6%, P = 0.26) or the length of stay (1.9 vs. 2.3, P = 0.18) between both groups. Clinical response rate of patients in the POEM groups was similar to that in the RHM group (94.3% vs. 88.5%, P = 0.48). POEM incurred significantly less total charges compared to LHM ($14481 vs. $17782, P = 0.02). POEM when performed in an endoscopy unit was similar in efficacy and safety to RHM. However, POEM was associated with significant cost savings ($3301/procedure).

  8. Peroral endoscopic myotomy for the treatment of esophageal achalasia: systematic review and pooled analysis.

    Science.gov (United States)

    Patel, K; Abbassi-Ghadi, N; Markar, S; Kumar, S; Jethwa, P; Zaninotto, G

    2016-10-01

    Peroral endoscopic myotomy (POEM) is a novel approach to performing esophageal myotomy for the treatment of achalasia. This review aims to assess subjective and objective metrics of achalasia treatment efficacy, perioperative adverse events and the incidence of postoperative gastroesophageal reflux disease in patients treated with POEM. Secondary aims include a pooled analysis comparison of the clinical outcomes and procedural safety of POEM versus laparoscopic Heller's myotomy (LHM). A systematic review of the literature, up to and including January 15, 2015, was conducted for studies reporting POEM outcomes. Studies comparing POEM to LHM were also included for the purpose of pooled analysis. Outcomes from 1122 POEM patients, from 22 studies, are reported in this systematic review. Minor operative adverse events included capno/pneumo-peritoneum (30.6%), capno/pneumo-thorax (11.0%) and subcutaneous emphysema (31.6%). Major operative adverse events included mediastinal leak (0.3%), postoperative bleeding (1.1%) and a single mortality (0.09%). There was an improvement in lower esophageal sphincter pressure and timed barium esophagram column height of 66% and 80% post-POEM, respectively. Symptom improvement was demonstrated with a pre- and post-POEM Eckardt score ± standard deviation of 6.8 ± 1.0 and 1.2 ± 0.6, respectively. Pre- and post-POEM endoscopy showed esophagitis in 0% and 19% of patients, respectively. The median (interquartile range) points scored for study quality was 15 (14-16) out of total of 32. Pooled analysis of three comparative studies between LHM and POEM showed similar results for adverse events, perforation rate, operative time and a nonsignificant trend toward a reduced length of hospital stay in the POEM group. In conclusion, POEM is a safe and effective treatment for achalasia, showing significant improvements in objective metrics and achalasia-related symptoms. Randomized comparative studies of LHM and POEM are required to determine the

  9. Per os infectivity of white spot syndrome virus (WSSV) in white-legged shrimp (Litopenaeus vannamei) and role of peritrophic membrane.

    Science.gov (United States)

    Thuong, Khuong Van; Tuan, Vo Van; Li, Wenfeng; Sorgeloos, Patrick; Bossier, Peter; Nauwynck, Hans

    2016-02-29

    As earlier observations on peroral infectivity of WSSV in white-legged shrimp are conflicting, here, a standardized peroral intubation technique was used to examine (i) the role of the physical composition of the viral inoculum and (ii) the barrier function of the PM. In a first experiment, the infectivity of a WSSV stock was compared by determining the SID50 by intramuscular injection, peroral inoculation or via feeding. The following titers were obtained: 10(8.77) SID50/g by intramuscular injection, 10(1.23) SID50/g by peroral inoculation and 10(0.73) SID50/g by feeding. These results demonstrated that 10(7.54)-10(8.03) infectious virus is needed to infect shrimp by peroral inoculation and via feeding. Next, it was examined if damage of the PM may increase the susceptibility for WSSV by peroral route. The infectivity of a virus stock was tested upon peroral inoculation of shrimp with and without removal of the PM and compared with the infectivity upon intramuscular inoculation. The virus titers obtained upon intramuscular injection and peroral inoculation of shrimp with and without PM were 10(8.63), 10(1.13) and 10(1.53) SID50/mL, respectively. This experiment confirmed the need of 10(7.1)-10(7.5) infectious virus to infect shrimp via peroral route and showed that the removal of the PM slightly but not significantly (p > 0.05) facilitated the infection of shrimp. This study indicated that WSSV contaminated feed is poorly infectious via peroral route, whereas it is highly infectious when injected into shrimp. The PM plays a minor role as internal barrier of shrimp against WSSV infection.

  10. Peroral Endoscopic Myotomy for Esophageal Achalasia: Outcomes of the First 100 Patients With Short-term Follow-up.

    Science.gov (United States)

    Familiari, Pietro; Gigante, Giovanni; Marchese, Michele; Boskoski, Ivo; Tringali, Andrea; Perri, Vincenzo; Costamagna, Guido

    2016-01-01

    Aim of this study is to report the mid-term outcomes of a large series of patients treated with peroral endoscopic myotomy (POEM) in a single European center. POEM is a recently developed treatment of achalasia, which combines the efficacy of surgical myotomy, with the benefits of an endoscopic procedure. Previous studies, including few patients with a short-term follow-up, showed excellent results on dysphagia relief. The first 100 adult patients treated in a single tertiary referral center were retrospectively identified and included in this study (41 men, mean age 48.4 years). Patients were treated according to a standard technique. Follow-up data, including clinical evaluation, and results of esophagogastroduodenoscopy (EGD), manometry, and pH monitoring were collected and analyzed. POEM was completed in 94% of patients. Mean operative time was 83 minutes (49-140  minutes). No complications occurred. Patients were fed after a median of 2 days (1-4 days). A mean follow-up of 11 months (3-24 months) was available for 92 patients. Clinical success was documented in 94.5% of patients. Twenty-four-hour pH monitoring documented Gastro-Esophageal Reflux Disease (GERD) in 53.4% of patients. However, only a minority of patients had heartburn (24.3%) or esophagitis (27.4%), and these patients were successfully treated with proton-pump inhibitors. Our results confirm the efficacy of POEM in a large series of patients, with a mean follow-up of 11 months. Should our results be confirmed by long-term follow-up studies, POEM may become one of the first-line therapies of achalasia in the next future.

  11. Det 'svage' subjekt. En undersøgelse af det litterære subjekts forandring i Antonio Tabucchis og Gianni Celatis forfatterskaber

    DEFF Research Database (Denmark)

    Lausten, Pia Schwarz

    Italiensk litteratur efter 1980; postmodernisme; subjektsforståelse; Antonio Tabucchi; Gianni Celati; Michail Bachtin; Gianni Vattimo......Italiensk litteratur efter 1980; postmodernisme; subjektsforståelse; Antonio Tabucchi; Gianni Celati; Michail Bachtin; Gianni Vattimo...

  12. The Culture of Memory in the ”Grandchildren Generation” in Denmark

    DEFF Research Database (Denmark)

    Bjerg, Helle

    2011-01-01

    En empirisk analyse af erindringskultur og historiebevidsthed om 2. verdenskrig og Holocaust i 3. generation efter 2. verdenskrig......En empirisk analyse af erindringskultur og historiebevidsthed om 2. verdenskrig og Holocaust i 3. generation efter 2. verdenskrig...

  13. Peroral endoscopic myotomy can improve esophageal motility in patients with achalasia from a large sample self-control research (66 patients.

    Directory of Open Access Journals (Sweden)

    Shuangzhe Yao

    Full Text Available Peroral endoscopic myotomy (POEM as a new approach to achalasia attracts broad attention. The primary objective of this study was to evaluate the results with esophageal motility after POEM through the first large sample clinical research.We have a self-control research with all patients (205 in total who underwent POEM from 2010 to 2014 at our Digestive Endoscopic Center, 66 patients of which underwent high resolution manometry (HRM before and after POEM in our motility laboratory. Follow-ups last for 5.6 months on average. Outcome variables analyzed included upper esophageal sphincter pressure (UESP, upper esophageal sphincter residual pressure (UESRP, lower esophageal sphincter pressure (LESP, lower esophageal sphincter residual pressure (LESRP and esophageal body peristalsis. We have a statistical analysis to illustrate how POEM impacts on the change of esophageal motility.The symptoms related to dysphagia were relieved in 95% of patients in recent term after POEM. While HRM showed a statistically significant reduction of URSRP, LESP and LESRP (P0.05 did not occur for these two groups on LESP and LESRP reduction.POEM clearly relieved the symptoms related to dysphagia by lowering the pressure of upper esophageal sphincter (UES and lower esophageal sphincter (LES,and other endoscopic treatment before POEM did not affect the improvement of LES pressure. These results are concluded from our short-term follow-up study, while the long-term efficacy remains to be further illustrated.Chinese Clinical Trial Register ChiCTR-TRC-12002204.

  14. Rutinemæssig igangsættelse i uge 39

    DEFF Research Database (Denmark)

    Rydahl, Eva; Hansen, Kit Dynnes; Schroll, Anne-Mette

    2016-01-01

    Flere epidemiologiske undersøgelser har vist, at risikoen for intrauterin mortalitet stiger efter 38. graviditetsuge for at øges betydeligt efter 42. graviditetsuge. Det har ført til, at amerikanske obstetrikere flirter med tanken om, at gravide rutinemæssigt skal have fødslen sat i gang efter ug...... 39 for at nedbringe forekomsten af intrauterin død. En gruppe danske jordemødre har set på evidens og på konsekvenser af tidligere igangsættelse i en dansk kontekst...

  15. Per-Oral Endoscopic Myotomy Versus Laparoscopic Heller Myotomy for Achalasia: A Meta-Analysis of Nonrandomized Comparative Studies.

    Science.gov (United States)

    Zhang, Yuan; Wang, Hongjuan; Chen, Xingdong; Liu, Lan; Wang, Hongbo; Liu, Bin; Guo, Jianqiang; Jia, Hongying

    2016-02-01

    We aimed to assess the short-term outcomes of per-oral endoscopic myotomy (POEM) compared with laparoscopic Heller myotomy (LHM) for achalasia through a meta-analysis of nonrandomized comparative studies.We searched PubMed, Embase, Medline, Cochrane Library, and Google Scholar for studies that compared POEM and LHM for achalasia and were published between January 1, 2008 and December 31, 2014. The Methodological Index for Nonrandomized Studies (MINORS) was used to evaluate the quality of the studies. Random- and fixed-effects meta-analytical models were used, and between-study heterogeneity was assessed.Four nonrandomized comparative studies that included 317 patients (125 in the POEM group and 192 in the LHM group) met our research criteria and were assessed. There were no differences between the POEM and LHM groups in terms of sex, preoperative Eckhart score, length of myotomy, operation time, length of hospital stay, and complications. The patients in the POEM group were older than those in the LHM group (MD =2.81, 95% CI 0.27-5.35; P = 0.03) with high between-study homogeneity (χ = 1.96, df = 2, I = 0%; P = 0.38). The patients in the POEM group had a lower Eckardt score after surgery compared with those in the LHM group (MD = -0.30, 95% CI -0.42 to -0.18; P < 0.001) with high between-study homogeneity (χ = 0.00, df = 1, I = 0%; P = 1.00).The efficacy and safety of POEM appear to be comparable to those of LHM. Multicenter and randomized trials with larger sample size are needed to further compare the efficacy and safety of POEM and LHM for the treatment of achalasia.

  16. Association of High-Resolution Manometry Metrics with the Symptoms of Achalasia and the Symptomatic Outcomes of Peroral Esophageal Myotomy.

    Science.gov (United States)

    Tang, Yurong; Xie, Chen; Wang, Meifeng; Jiang, Liuqin; Shi, Ruihua; Lin, Lin

    2015-01-01

    High-resolution manometry (HRM) has improved the accuracy of manometry in detecting achalasia and has helped distinguish between clinically relevant subtypes. This study investigated whether HRM metrics correlate with the achalasia symptoms and symptomatic outcomes of peroral esophageal myotomy (POEM). Of the 30 patients who were enrolled, 25 were treated with POEM, 12 of who underwent HRM after 3 months. All the patients completed the Eckardt score questionnaires, and those who underwent POEM were followed up for about 6 months. Pearson correlation was used to assess the relationship between the HRM metrics and symptoms and outcomes. The integrated relaxation pressure (IRP) score positively correlated with the total Eckardt score, regurgitation score and weight loss score in all the patients, and with the weight loss score in type I achalasia. In 25 patients (10 patients, type I; 15 patients, type II) who underwent POEM, the total Eckardt scores and individual symptom scores significantly decreased after surgery. Changes in the Eckardt scores were similar between type I and type II. Further, the Eckardt scores and weight loss score changes were positively correlated with baseline IRP. Twelve patients (4 patients, type I; 8 patients, type II) underwent HRM again after POEM. IRP changed significantly after POEM, as did the DEP in type II. The IRP changes after POEM were positively correlated with the Eckardt score changes. IRP is correlated with the symptoms and outcomes of achalasia patients. Thus, HRM is effective for assessing the severity of achalasia and can predict the efficacy of POEM.

  17. Clinical Practice Update: The Use of Per-Oral Endoscopic Myotomy in Achalasia: Expert Review and Best Practice Advice From the AGA Institute.

    Science.gov (United States)

    Kahrilas, Peter J; Katzka, David; Richter, Joel E

    2017-11-01

    The purpose of this review is to describe a place for per-oral endoscopic myotomy (POEM) among the currently available robust treatments for achalasia. The recommendations outlined in this review are based on expert opinion and on relevant publications from PubMed and EMbase. The Clinical Practice Updates Committee of the American Gastroenterological Association proposes the following recommendations: 1) in determining the need for achalasia therapy, patient-specific parameters (Chicago Classification subtype, comorbidities, early vs late disease, primary or secondary causes) should be considered along with published efficacy data; 2) given the complexity of this procedure, POEM should be performed by experienced physicians in high-volume centers because an estimated 20-40 procedures are needed to achieve competence; 3) if the expertise is available, POEM should be considered as primary therapy for type III achalasia; 4) if the expertise is available, POEM should be considered as treatment option comparable with laparoscopic Heller myotomy for any of the achalasia syndromes; and 5) post-POEM patients should be considered high risk to develop reflux esophagitis and advised of the management considerations (potential indefinite proton pump inhibitor therapy and/or surveillance endoscopy) of this before undergoing the procedure. Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

  18. Peroral endoscopic myotomy (POEM) vs laparoscopic Heller myotomy (LHM) for the treatment of Type III achalasia in 75 patients: a multicenter comparative study.

    Science.gov (United States)

    Kumbhari, Vivek; Tieu, Alan H; Onimaru, Manabu; El Zein, Mohammad H; Teitelbaum, Ezra N; Ujiki, Michael B; Gitelis, Matthew E; Modayil, Rani J; Hungness, Eric S; Stavropoulos, Stavros N; Shiwaku, Hiro; Kunda, Rastislav; Chiu, Philip; Saxena, Payal; Messallam, Ahmed A; Inoue, Haruhiro; Khashab, Mouen A

    2015-06-01

    Type III achalasia is characterized by rapidly propagating pressurization attributable to spastic contractions. Although laparoscopic Heller myotomy (LHM) is the current gold standard management for type III achalasia, peroral endoscopic myotomy (POEM) is conceivably superior because it allows for a longer myotomy. Our aims were to compare the efficacy and safety of POEM with LHM for type III achalasia patients. A retrospective study of 49 patients who underwent POEM for type III achalasia across eight centers were compared to 26 patients who underwent LHM at a single institution. Procedural data were abstracted and pre- and post-procedural symptoms were recorded. Clinical response was defined by improvement of symptoms and decrease in Eckardt stage to ≤ 1. Secondary outcomes included length of myotomy, procedure duration, length of hospital stay, and rate of adverse events. Clinical response was significantly more frequent in the POEM cohort (98.0 % vs 80.8 %; P = 0.01). POEM patients had significantly shorter mean procedure time than LHM patients (102 min vs 264 min; P myotomy (16 cm vs 8 cm; P myotomy than LHM, which may result in improved clinical outcomes. POEM appears to be an effective and safe alternative to LHM in patients with type III achalasia.

  19. Gradiva, Pigen der går fremad

    DEFF Research Database (Denmark)

    Holm, Henrik

    2013-01-01

    Analyse af kopi i gips efter antikt relief, kaldet "Gradiva". Fra Sigmund Freud over Surrelismen til Alain Robbe-Grillet.......Analyse af kopi i gips efter antikt relief, kaldet "Gradiva". Fra Sigmund Freud over Surrelismen til Alain Robbe-Grillet....

  20. Listed Companies - between Company Law and Financial Market Law in Denmark

    DEFF Research Database (Denmark)

    Clausen, Nis Jul

    2010-01-01

    Efter en analyse af udviklingen i en række landes selskabs- og børsretlige reformen analyseres det, hvorledes skillelinjen mellem selskabsretlig og børsretlig regulering er i dansk ret efter reformen af selskabsloven i 2009/2010...

  1. Bolig for livet - Home for life

    DEFF Research Database (Denmark)

    Hansen, Ellen Kathrine; Lildholdt, Rikke

    2009-01-01

    Visionen, designprocessen og gennemgang af projektet Bolig for livet, det første byggeri efter Active House visionen og danske + energihus.......Visionen, designprocessen og gennemgang af projektet Bolig for livet, det første byggeri efter Active House visionen og danske + energihus....

  2. Arthur Schopenhauers betydning for Johannes Jørgensens omvendelse

    DEFF Research Database (Denmark)

    Nord, Johan Christian

    2013-01-01

    Artikel om Johannes Jørgensens interesse for Arthur Schopenhauers filosofi i tiden lige op til og efter Jørgensens konversion til katolicismen......Artikel om Johannes Jørgensens interesse for Arthur Schopenhauers filosofi i tiden lige op til og efter Jørgensens konversion til katolicismen...

  3. Use of primary health care prior to a postpartum psychiatric episode

    DEFF Research Database (Denmark)

    Munk-Olsen, Trine; Pedersen, Henrik Søndergaard; Laursen, Thomas Munk

    2015-01-01

    Mange kvinder udvikler psykisk sygdom efter en fødsel. Dette studie undersøger mønstre i kontakten med den praktiserende læge for de kvinder, der rammes efter en fødsel. Resultaterne viser, at de kvinder, som senere udviklede psykisk sygdom, havde betydeligt flere konsultationer hos deres egen læ...... mere forskning på området, hvis det skal kunne forudsiges mere præcist, hvilke kvinder der rammes af fx depression efter en fødsel. Den nye viden vil give bedre muligheder for en tidlig forebyggende indsats, som vil kunne forbedre den enkelte kvindes prognose....

  4. Faste vendinger med en bestemt betydning

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Bjærge, Esben

    2012-01-01

    Ordbogen giver oplysnnger om ca. 17.000 idiomer, ordsprog, bevingede ord og andre faste vendinger, som kan findes og er ordnet efter betydningen.......Ordbogen giver oplysnnger om ca. 17.000 idiomer, ordsprog, bevingede ord og andre faste vendinger, som kan findes og er ordnet efter betydningen....

  5. Confronting the Imaginary of the Artificial. From cyberspace to the internet and from the internet to us

    DEFF Research Database (Denmark)

    Michelsen, Anders Ib

    Afhandlingen undersøger det “artificielle efter computeren”, dvs. efter opfindelsen af “computation” (maskinberegnelig databehandling i bred forstand) i midten af det 20 århundrede som en form for kreativ imagination: det vil sige som en kreativ horisont for at forestille sig, artikulere og orien...

  6. Coaching af nystartede universitetsstuderende

    DEFF Research Database (Denmark)

    Spaten, Ole Michael; Løkken, Lillith Olesen; Kyndesen, Anna Imer

    2011-01-01

    ). Kvalitative interviews med fire deltagere før og efter coaching interventionen. Metode: Ni erfarne coaches gennemførte fire sessioner med 52 første semesters studerende fra Aalborg universitet. Deltagerne udfyldte DASS-21, Subjective Wellbeing Scale og Adult Hope Scale før og efter coaching interventionerne...

  7. Starskuddet til det postfaktuelle demokrati: "Alternative kendsgerninger"

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella

    2017-01-01

    Et nyt begreb har set dagens lys efter Donald Trumps tiltrædelse som USA’s 45. præsident – ”alternative kendsgerninger”.......Et nyt begreb har set dagens lys efter Donald Trumps tiltrædelse som USA’s 45. præsident – ”alternative kendsgerninger”....

  8. Notat vedr. muligheder for at styrke det faglige niveau i matematik og naturfag

    DEFF Research Database (Denmark)

    Busch, Henrik; Horst, Sebastian

    Dette notat er i foråret 2005 udarbejdet af Henrik Busch og Sebastian Horst for Undervisnings-ministeriet i forbindelse med forberedelsen til Globaliseringsrådets arbejde i efteråret 2005. Notatet er i november 2005 gjort offentligt tilgængeligt efter aftale med Undervisningsministeriet. I den fo...

  9. Peroral endoscopic myotomy is a viable option for failed surgical esophagocardiomyotomy instead of redo surgical Heller myotomy: a single center prospective study.

    Science.gov (United States)

    Onimaru, Manabu; Inoue, Haruhiro; Ikeda, Haruo; Yoshida, Akira; Santi, Esperanza Grace; Sato, Hiroki; Ito, Hiroaki; Maselli, Roberta; Kudo, Shin-ei

    2013-10-01

    Surgical Heller myotomy has high rates of successful long-term results, but failed cases still remain. Moreover, the treatment strategy in patients with surgical myotomy failure is controversial. Recently, peroral endscopic myotomy (POEM) was reported to be efficient and safe in primary treatment of achalasia. In this study, we aimed to evaluate the efficacy and safety of POEM for surgical myotomy failure as a rescue second-line treatment, and we discuss the treatment options adapted in achalasia recurrence. A total of 315 consecutive achalasia patients received POEM from September 2008 to December 2012 in our hospital. Eleven (3.5%) patients who had persistent or recurrent achalasia and had received surgical myotomy as a first-line treatment from other hospitals were included in this study. Patient background, barium swallow studies, esophagogastroduodenoscopy (EGD), manometry, and symptom scores were prospectively evaluated. In principle, all patients in whom surgical myotomy failed received pneumatic balloon dilatation (PBD) as the first line "rescue" treatment, and only if PBD failed were patients considered for rescue POEM. The PBD alone was effective in 1 patient, and in the remaining 10 patients, rescue POEM was performed successfully without complications. Three months after rescue POEM, significant reduction in lower esophageal sphincter (LES) resting pressures (22.1 ± 6.6 mmHg vs 10.9 ± 4.5 mmHg, p myotomy were excellent. Long-term results are awaited. Copyright © 2013 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

  10. Evolution in Lego. A physical simulation of adaptation by natural selection

    DEFF Research Database (Denmark)

    Christensen-Dalsgaard, Jakob; Kanneworff, Morten

    2009-01-01

    En simulering af mekanismen bag naturlig udvælgelse ved at bruge legorger, organismer bygget af 6 legoklodser, og med en genetisk kode, der bestemmer hvordan klodserne er placeret og dermed formen på dyret. Legorgerne tildeles fitness efter, hvor langt de kan bevæge sig. Efter fem generationers s...

  11. Hvorfor sætter folk ild til sig selv?

    DEFF Research Database (Denmark)

    Harrebye, Silas

    2011-01-01

    Mellemøsten brød i brand efter en mand satte ild til sig selv. Et bevis på revolutioner skal selvantændes?......Mellemøsten brød i brand efter en mand satte ild til sig selv. Et bevis på revolutioner skal selvantændes?...

  12. En kvalitativ undersøgelse af gravides valg af nakkefoldscanning

    DEFF Research Database (Denmark)

    Sørensen, Stina Lou; Dahl, Katja; Beck risør, Mette

    2007-01-01

    valg. Vi ønskede at undersøge informationens rolle i den gravides forståelse og valg af nakkefoldskanning. Materiale og metoder: Seksogtyve gravide blev interviewet efter første svangrekonsultation og igen efter misdannelseskanningen. Undersøgelsesresultaterne i denne artikel stammer primært fra første...

  13. Virtuelle lærings- og kommunikationsmiljøer i rehabiliteringen af mennesker med afasi

    DEFF Research Database (Denmark)

    Konnerup, Ulla

    2010-01-01

    Afasi er en betegnelse for forstyrrelser af sprogfunktionen efter en hjerne- skade. Skaden kan være opstået efter en blodprop, hjerneblødning eller traumer, men kan også skyldes andre skader, hvor hjernens blodkar er læderet . Afasi medfører kommunikationsforstyrrelser i varierende grad, alt ef...

  14. Toneren kvalitetskrise på Hawaii

    DEFF Research Database (Denmark)

    Redvall, Eva Novrup

    2012-01-01

    Syv år efter ’Sideways’ er Alexander Payne omsider tilbage med et nyt galleri af kantede karakterer og komplicerede livskriser i Hawaii-herligheden ’The Descendants’......Syv år efter ’Sideways’ er Alexander Payne omsider tilbage med et nyt galleri af kantede karakterer og komplicerede livskriser i Hawaii-herligheden ’The Descendants’...

  15. Levende branding

    DEFF Research Database (Denmark)

    Schultz, Majken

    2013-01-01

    Mottoet »Boston Strong« efter bombeangrebet ved Boston Marathon viser, at ingen branding er stærkere end det, der vokser ud af det levede liv.......Mottoet »Boston Strong« efter bombeangrebet ved Boston Marathon viser, at ingen branding er stærkere end det, der vokser ud af det levede liv....

  16. Din tandbørste og pejsen er online

    DEFF Research Database (Denmark)

    Damsgaard, Jan

    2016-01-01

    Det er snart definitivt slut med de store mysterier om flys forsvinden og massive eftersøgninger efter overlevende. Danske Naviair er i disse år med til at sende 66 satellitter i kredsløb om Jorden. Så kan alle kommercielle fly følges, uanset hvor på jordkloden de befinder sig....

  17. Nyfigen robot

    DEFF Research Database (Denmark)

    Pedersen, Jens Olaf Pepke

    2013-01-01

    Marsudforskning. Det rullende laboratorium Curiosity har nu kørt rundt på Mars i et halvt år. Hidtil har der ikke været de store overraskelser, og det er helt efter planen. Men nu har den kurs mod det 5.500 meter høje bjerg Aeolis Mons for at bore efter sedimenter....

  18. Post-construction evaluation of bird abundances and distributions in the Horns Rev 2 offshore wind farm area, 2011 and 2012

    DEFF Research Database (Denmark)

    Petersen, Ib Krag; Nielsen, Rasmus Due; Mackenzie, Monique L.

    2014-01-01

    Optællinger af fugle fra fly efter linjetransekt-metoden blev anvendt til at beskrive fuglenes antal og udbredelse i undersøgelsesområdet. Ti optællinger før Horns Rev 2 mølleparkens opførelse blev sammenlignet med ti optællinger foretaget efter parkens etablering. Rumlig modellering blev anvendt...

  19. Bulkister og Bådgrav ved Bulbrogård

    DEFF Research Database (Denmark)

    Bican, Josefine Franck

    2012-01-01

    oldsager. I seks af gravene var der bevaret kistespor, i fem tilfælde efter bulkister og i ét tilfælde efter en stammebåd anvendt som kiste. Fire af gravene indeholdt gravgods. Gravens konstruktion, udformning og indhold diskuteres med særlig fokus på bådgraven, og der sammenlignes med andre fladmarksgrave...

  20. Clusters in an age of increasing internationalisation

    DEFF Research Database (Denmark)

    Illeris, Sven

    2008-01-01

    Artiklen studerer tekstil- og beklædningsklyngen i Herning, som opstod i 1930erne og voksede efter 2. verdenskrig. Da den blev udsat for konkurrence fra lavtlønslandene i Central- og Østeuropa og Østasien efter 1990, overlevede den næsten uden arbejdsløshed. På denne baggrund diskuteres spørgsmål...

  1. Historiens mest groteske pengepolitiske eksperiment?

    DEFF Research Database (Denmark)

    Hougaard Nielsen, Rasmus

    2017-01-01

    Er bitcoin en boble? Givetvis. Men føj den bare til rækken af bobler, som verdens mest magtfulde centralbankchefer har pustet op efter finanskrisen, skriver økonom.......Er bitcoin en boble? Givetvis. Men føj den bare til rækken af bobler, som verdens mest magtfulde centralbankchefer har pustet op efter finanskrisen, skriver økonom....

  2. Offentlig administration

    DEFF Research Database (Denmark)

    Nielsen, Elof Nellemann; Rehr, Preben René

    En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer.......En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer....

  3. On the estimation of short- and long-run elasticities in U.S. petroleum consumption : comment

    DEFF Research Database (Denmark)

    Bentzen, Jan Børsen; Engsted, Tom

    1996-01-01

    Artiklen, der er formet som en kommentar til en tidligere artikel af Clifton Jones i Southern Economic Journal, anvender kointegrationsmetoder til analyse af efterspørgslen efter petroleum i USA.......Artiklen, der er formet som en kommentar til en tidligere artikel af Clifton Jones i Southern Economic Journal, anvender kointegrationsmetoder til analyse af efterspørgslen efter petroleum i USA....

  4. Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report

    DEFF Research Database (Denmark)

    Dirksen, Carsten; Hansen, Dorte L; Madsbad, Sten

    2010-01-01

    into the bypassed gastric remnant and on the second day perorally. Plasma glucose, insulin, C-peptide, glucagon, incretin hormones, peptide YY, and free fatty acids were measured. RESULTS: Peroral feeding reduced 2-h postprandial plasma glucose (7.8 vs. 11.1 mmol/l) and incremental area under the glucose curve (iAUC......) (0.33 vs. 0.49 mmol . l(-1) . min(-1)) compared with gastroduodenal feeding. beta-Cell function (iAUC(Cpeptide/Glu)) was more than twofold improved during peroral feeding, and the glucagon-like peptide (GLP)-1 response increased nearly fivefold. CONCLUSIONS: Improvement in postprandial glucose......OBJECTIVE: To examine after gastric bypass the effect of peroral versus gastroduodenal feeding on glucose metabolism. RESEARCH DESIGN AND METHODS: A type 2 diabetic patient was examined on 2 consecutive days 5 weeks after gastric bypass. A standard liquid meal was given on the first day...

  5. Efficacy of peroral endoscopic myotomy compared with other invasive treatment options for the different esophageal motor disorders

    Directory of Open Access Journals (Sweden)

    Fermín Estremera-Arévalo

    Full Text Available Introduction: Peroral endoscopic myotomy (POEM has been performed since 2008 on more than 5,000 patients. It has proven to be highly effective in the treatment of achalasia and has shown promising outcomes for other esophageal motility spastic disorders. Methods: A literature review of the efficacy of POEM compared to the previous invasive treatments for different esophageal motility disorders was performed. The application in the pediatric and elderly populations and its role as a rescue therapy after other procedures are also outlined. Results: Short-term outcomes are similar to laparoscopic Heller myotomy (LHM and pneumatic endoscopic dilation (PD (clinical success > 90% for achalasia subtypes I and II. Mid-term outcomes are comparable to LHM and overcome results obtained after PD (> 90% vs ~50%. With regard to type III achalasia, POEM efficacy is 98% compared to 80.8% for LHM and the PD success remains at 40%. With regard to spastic esophageal disorders (SED, POEM has an effectiveness of 88% and 70% for distal esophageal spasm (DES and jackhammer esophagus (JE respectively. A response of 95% in patients with sigmoid esophagus has been reported. POEM has been performed in pediatric and elderly populations and has obtained a higher efficacy than PD in pediatric series (100% vs 33% without greater adverse events. Previous treatments do not seem to hinder POEM results with excellent response rates, including 97% in post LHM and 100% in a re-POEM series. Final considerations: POEM has shown excellent short and mid-term results for all subtypes of achalasia but long-term results are not yet available. The promising results in SED may make POEM the first-line treatment for SED. A high-safety profile and efficacy have been shown in elderly and pediatric populations. Previous treatments do not seem to diminish the success rate of POEM. Core tip: POEM has emerged as an efficient treatment option for all subtypes of achalasia and other scenarios

  6. Efficacy of peroral endoscopic myotomy compared with other invasive treatment options for the different esophageal motor disorders.

    Science.gov (United States)

    Estremera-Arévalo, Fermín; Albéniz, Eduardo; Rullán, María; Areste, Irene; Iglesias, Rosa; Vila, Juan José

    2017-08-01

    Peroral endoscopic myotomy (POEM) has been performed since 2008 on more than 5,000 patients. It has proven to be highly effective in the treatment of achalasia and has shown promising outcomes for other esophageal motility spastic disorders. A literature review of the efficacy of POEM compared to the previous invasive treatments for different esophageal motility disorders was performed. The application in the pediatric and elderly populations and its role as a rescue therapy after other procedures are also outlined. Short-term outcomes are similar to laparoscopic Heller myotomy (LHM) and pneumatic endoscopic dilation (PD) (clinical success > 90%) for achalasia subtypes I and II. Mid-term outcomes are comparable to LHM and overcome the results obtained after PD (> 90% vs ~50%). With regard to type III achalasia, POEM efficacy is 98% compared to 80.8% for LHM and the PD success remains at 40%. With regard to spastic esophageal disorders (SED), POEM has an effectiveness of 88% and 70% for distal esophageal spasm (DES) and jackhammer esophagus (JE) respectively. A response of 95% in patients with sigmoid esophagus has been reported. POEM has been performed in pediatric and elderly populations and has obtained a higher efficacy than PD in pediatric series (100% vs 33%) without greater adverse events. Previous treatments do not seem to hinder POEM results with excellent response rates, including 97% in post LHM and 100% in a re-POEM series. Final considerations: POEM has shown excellent short and mid-term results for all subtypes of achalasia but long-term results are not yet available. The promising results in SED may make POEM the first-line treatment for SED. A high-safety profile and efficacy have been shown in elderly and pediatric populations. Previous treatments do not seem to diminish the success rate of POEM. Core tip: POEM has emerged as an efficient treatment option for all subtypes of achalasia and other scenarios (including previous treatments and elderly

  7. Anesthetic considerations for patients with esophageal achalasia undergoing peroral endoscopic myotomy: a retrospective case series review.

    Science.gov (United States)

    Löser, Benjamin; Werner, Yuki B; Punke, Mark A; Saugel, Bernd; Haas, Sebastian; Reuter, Daniel A; Mann, Oliver; Duprée, Anna; Schachschal, Guido; Rösch, Thomas; Petzoldt, Martin

    2017-05-01

    Peroral endoscopic myotomy (POEM) is a novel technique for treating esophageal achalasia. During POEM, carbon dioxide (CO 2 ) is insufflated to aid surgical dissection, but it may inadvertently track into surrounding tissues, causing systemic CO 2 uptake and tension capnoperitoneum. This in turn may affect cardiorespiratory function. This study quantified these cardiorespiratory effects and treatment by hyperventilation and percutaneous abdominal needle decompression (PND). One hundred and seventy-three consecutive patients who underwent POEM were included in this four-year retrospective study. Procedure-related changes in peak inspiratory pressure (p max ), end-tidal CO 2 levels (etCO 2 ), minute ventilation (MV), mean arterial pressure (MAP), and heart rate (HR) were analyzed. We also quantified the impact of PND on these cardiorespiratory parameters. During the endoscopic procedure, cardiorespiratory parameters increased from baseline: p max 15.1 (4.5) vs 19.8 (4.7) cm H 2 O; etCO 2 4.5 (0.4) vs 5.5 (0.9) kPa [34.0 (2.9) vs 41.6 (6.9) mmHg]; MAP 73.9 (9.7) vs 99.3 (15.2) mmHg; HR 67.6 (12.4) vs 85.3 (16.4) min -1 (P < 0.001 for each). Hyperventilation [MV 5.9 (1.2) vs 9.0 (1.8) L·min -1 , P < 0.001] was applied to counteract iatrogenic hypercapnia. Individuals with tension capnoperitoneum treated with PND (n = 55) had higher peak p max values [22.8 (5.7) vs 18.4 (3.3) cm H 2 O, P < 0.001] than patients who did not require PND. After PND, p max [22.8 (5.7) vs 19.9 (4.3) cm H 2 O, P = 0.045] and MAP [98.2 (16.3) vs 88.6 (11.8) mmHg, P = 0.013] decreased. Adverse events included pneumothorax (n = 1), transient myocardial ischemia (n = 1), and subcutaneous emphysema (n = 49). The latter precluded immediate extubation in eight cases. Postanesthesia care unit (PACU) stay was longer in individuals with subcutaneous emphysema than in those without [74.9 min (34.5) vs 61.5 (26.8 min), P = 0.007]. Carbon dioxide insufflation during POEM produces systemic CO 2 uptake and

  8. Long-term risk of atrial fibrillation after the death of a partner

    DEFF Research Database (Denmark)

    Graff, Simon; Fenger-Grøn, Morten; Christensen, Bo

    2016-01-01

    Dette studie viser, at mennesker, som for nylig har mistet deres partner, har en øget risiko for at udvikle uregelmæssig hjerterytme i op til ét år efter tabet. Den øgede risiko forekommer i op til et år efter tabet, og den største risiko ses hos efterladte på under 60 år og ved uventede dødsfald...

  9. Predicting effects and risk of relapse into depression: The Danish ECT/MRI project

    DEFF Research Database (Denmark)

    Gbyl, Krzysztof; Rosenberg, Raben; Larsson, Henrik Bo Wiberg

    Formål: Vi ønsker at undersøge hjernen hos patienter med svær depression før og efter elektrokonvulsiv terapi (ECT), samt ved en kontrol efter 6 måneder med det formål at: 1. undersøge hjernevævet så en evt. skadelig effekt af ECT-behandling kan udelukkes 2. belyse mekanismerne bag ECT for at fin...

  10. Hvorfor skal Adam betale børnepenge, når Eva har bedraget ham?

    DEFF Research Database (Denmark)

    Petersen, Thomas Søbirk

    2016-01-01

    Juridisk abort bør være en mulighed for mænd, der er blevet bedraget, bestjålet eller som har brugt prævention, der ikke virker efter hensigten.......Juridisk abort bør være en mulighed for mænd, der er blevet bedraget, bestjålet eller som har brugt prævention, der ikke virker efter hensigten....

  11. Gastroesophageal reflux disease after peroral endoscopic myotomy: Analysis of clinical, procedural and functional factors, associated with gastroesophageal reflux disease and esophagitis.

    Science.gov (United States)

    Familiari, Pietro; Greco, Santi; Gigante, Giovanni; Calì, Anna; Boškoski, Ivo; Onder, Graziano; Perri, Vincenzo; Costamagna, Guido

    2016-01-01

    Peroral endoscopic myotomy (POEM) does not include any antireflux procedure, resulting in a certain risk of iatrogenic gastroesophageal reflux disease (GERD). The aim of the present study was to evaluate the incidence of iatrogenic GERD after POEM and identify preoperative, perioperative and postoperative factors associated with GERD. All patients treated at a single center who had a complete GERD evaluation after POEM were included in the study. Demographics, preoperative and follow-up data, results of functional studies and procedural data were collected and analyzed. A total of 103 patients (mean age 46.6 years, 47 males) were included. Postoperative altered esophageal acid exposure was attested in 52 patients (50.5%). A total of 19 patients (18.4%) had heartburn and 21 had esophagitis (20.4%). Overall, a clinically relevant GERD (altered esophageal acid exposure, associated with heartburn and/or esophagitis) was diagnosed in 30 patients (29.1%). Correlation between the severity of esophageal acid exposure with heartburn and esophagitis after POEM was found. Patients with heartburn had a lower postoperative 4-second integrated relaxation pressure compared to patients without symptoms (7.6 ± 3.8 mmHg vs 10.01 ± 4.4 mmHg, p<0.05). No correlations were identified with patient sex, age, postoperative body mass index, esophageal shape (sigmoid vs non sigmoid), lower esophageal sphincter pressure, length of myotomy, previous therapies and type of achalasia at high-resolution manometry. Preoperative, perioperative or postoperative factors minimally correlated with GERD after POEM. Clinically relevant GERD was identified in less than one-third of patients, but all patients were well controlled with medical therapy. © 2015 The Authors Digestive Endoscopy © 2015 Japan Gastroenterological Endoscopy Society.

  12. Effectiveness of peroral endoscopic myotomy in the treatment of achalasia: a pilot trial in Chinese Han population with a minimum of one-year follow-up.

    Science.gov (United States)

    Ling, Ting Sheng; Guo, Hui Min; Yang, Tian; Peng, Chun Yan; Zou, Xiao Ping; Shi, Rui Hua

    2014-07-01

    To investigate the outcomes of Chinese Han patients who underwent peroral endoscopic myotomy (POEM) for achalasia. Patients undergoing POEM for achalasia at the Affiliated Drum Tower Hospital of Nanjing University Medical School were prospectively enrolled in this study, with a follow-up duration of at least one year. Their outcomes were evaluated by analyzing esophageal manometry, timed barium esophagogram and 36-Item Short Form Health Survey (SF-36), which were performed before surgery, 5 days after surgery and at the last follow-up. Patients' symptom relief was considered the primary outcome. Secondary outcomes included lower esophageal sphincter (LES) pressure, esophageal emptying, patients' quality of life (QoL) and procedure-related complications. Eighty-seven patients were included in the study. Eckardt score after POEM was remarkably lower than the preoperative score (0.4 ± 0.7 vs 7.1 ± 2.1, P = 0.001). The preoperative LES pressure was 32.4 ± 15.3 mmHg, which was decreased to 3.8 ± 3.9 mmHg immediately after surgery. The height of the barium column at 1 min after barium swallow was significantly reduced after treatment (11.7 ± 1.2 cm vs 3.2 ± 1.6 cm, P achalasia, which can relieve the symptoms of achalasia by improving esophageal emptying and lowering LES pressure. © 2014 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

  13. Den europæiske drøm - om EU

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2007-01-01

    Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)......Anmeldelse af: Jeremy Rifkin: Den europæiske drøm (Informations Forlag, 2006). Oversat fra engelsk efter: "The European Dream: How Europe's Vision of the Future Is Quietly Eclipsing the American Dream" (2004)...

  14. Hitler blev mere populær i de første år ved magten

    DEFF Research Database (Denmark)

    Østergaard, Uffe

    2018-01-01

    Historisk set. Ønsket om revanche efter Versailles-freden var vigtigt for mange tyskere, men ønsket om arbejde gjorde udslaget. Kommentar i anledning af årsdagen for Hitlers magtovertagelse den 30. januar 1933.......Historisk set. Ønsket om revanche efter Versailles-freden var vigtigt for mange tyskere, men ønsket om arbejde gjorde udslaget. Kommentar i anledning af årsdagen for Hitlers magtovertagelse den 30. januar 1933....

  15. Del buen lugar al no-lugar

    DEFF Research Database (Denmark)

    Gustafsson, Jan

    Dette paper tager udgangspunkt i utopien som teoretisk begreb og i begrebets dobbelte etymologi og anvender det til en diskussion af forestillingen om Cuba i film og litteratur i perioden efter del 'specielle periode'.......Dette paper tager udgangspunkt i utopien som teoretisk begreb og i begrebets dobbelte etymologi og anvender det til en diskussion af forestillingen om Cuba i film og litteratur i perioden efter del 'specielle periode'....

  16. Histomorphometric characteristics of immune cells in small intestine of pigs perorally immunized with vaccine candidate F18ac+ nonenterotoxigenic E. coli strain

    Directory of Open Access Journals (Sweden)

    I. Valpotic

    2009-12-01

    Full Text Available Colidiarrhea and colienterotoxemia caused by F4+ and/or F18+ enterotoxigenic E. coli (ETEC strains are the most prevalent infections of suckling and weaned pigs. Here we tested the immunogenicity and protective effectiveness of attenuated F18ac+ non-ETEC vaccine candidate strain against challenge infection with F4ac+ ETEC strain by quantitative phenotypic analysis of small intestinal leukocyte subsets in weaned pigs. We also evaluated levamisole as an immune response modifier (IRM and its adjuvanticity when given in the combination with the experimental vaccine. The pigs were parenterally immunized with either levamisole (at days -2, -1 and 0 or with levamisole and perorally given F18ac+ non-ETEC strain (at day 0, and challenged with F4ac+ ETEC strain 7 days later. At day 13 the pigs were euthanatized and sampled for immunohistological/histomorphometrical analyses. Lymphoid CD3+, CD45RA+, CD45RC+, CD21+, IgA+ and myeloid SWC3+ cell subsets were identified in jejunal and ileal epithelium, lamina propria and Peyer’s patches using the avidin-biotin complex method, and their numbers were determined by computer-assisted histomorphometry. Quantitative immunophenotypic analyses showed that levamisole treated pigs had highly increased numbers of jejunal CD3+, CD45RC+ and SWC3+ cells (p<0.05 as compared to those recorded in nontreated control pigs. In the ileum of these pigs we have recorded that only CD21+ cells were significantly increased (p<0.01. The pigs that were treated with levamisole adjuvanted experimental vaccine had significantly increased numbers of all tested cell subsets in both segments of the small intestine. It was concluded that levamisole adjuvanted F18ac+ non-ETEC vaccine was a requirement for the elicitation of protective gut immunity in this model; nonspecific immunization with levamisole was less effective, but confirmed its potential as an IRM.

  17. Recombinant interleukin 6 with M cell-targeting moiety produced in Lactococcus lactis IL1403 as a potent mucosal adjuvant for peroral immunization.

    Science.gov (United States)

    Li, Hui-Shan; Piao, Da-Chuan; Jiang, Tao; Bok, Jin-Duck; Cho, Chong-Su; Lee, Yoon-Seok; Kang, Sang-Kee; Choi, Yun-Jaie

    2015-04-15

    Development and application of safe and effective mucosal adjuvants are important to improve immunization efficiency in oral vaccine. Here, we report a novel mucosal adjuvant, IL-6-CKS9, a recombinant cytokine generated by conjugating an M cell-targeting peptide (CKS9) with c-terminus of the murine interleukin 6 (IL-6), which facilitated enhancement of mucosal immune response. Lactococcus lactis IL1403, a food-grade strain of lactic acid bacteria (LAB) which is widely used in dairy industry, was used as a host cell to express and secrete the IL-6-CKS9 for a mucosal vaccine adjuvant. The recombinant L. lactis IL1403 secreting IL-6-CKS9 was orally administered with a model antigen protein, M-BmpB (Brachyspira membrane protein B conjugated with CKS9), to BALB/c mice for mucosal immunization. ELISA analyses showed consistent enhancement tendencies in induction of anti-M-BmpB antibody levels both with mucosal (IgA) and systemic (IgG) immune responses in IL-6-CKS9-LAB treated group compared with other groups tested by conducting two separated mice immunization assays. In addition, we characterized that the oral administration of model protein antigen with live LAB producing IL-6-CKS9 could induce both Th1 and Th2 type immune responses by analysis of the specific anti-BmpB IgG1 and IgG2a isotypes in the sera and also investigated possible oral tolerance in our vaccine strategy. Collectively, our results showed successful production and secretion of recombinant murine IL-6 with M cell-targeting moiety (IL-6-CKS9) from L. lactis IL1403 and demonstrated the live recombinant LAB producing IL-6-CKS9 could have a potential to be used as an efficient adjuvant for peroral vaccination. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Successful peroral endoscopic myotomy performed in Endoscopy Department as a radical, long-term treatment for esophageal achalasia - the Greek experience.

    Science.gov (United States)

    Eleftheriadis, Nikolas; Eleftheriadou, Eleni Damianos

    2017-01-01

    Peroral endoscopic myotomy (POEM) has been considered as a minimal-invasive, innovative technique for long-term treatment of all types of esophageal achalasia and other esophageal motility disorders. We report on 20 consecutive Greek patients with manometrically proved esophageal achalasia (14 patients with type I, 4 with type II, 2 with type III, and 4 with sigmoid esophagus), with an age range of 32-92 years, mean age 59 years, 12 males, successfully treated by POEM from 2013 to 2015. The Eckardt score was 7-12 (type III). Seventeen (85%) POEM procedures were performed in the Endoscopy Department, according to a previous study. During POEM, CO 2 insufflation was mandatory, while the Triangle Tip knife was the only knife used in all procedures. Eckardt score, esophagogram and manometry before and after performing POEM were used for evaluation of our results. The follow-up period was 6 months to 3 years. Selective circular myotomy, 10-13 cm in length, was successfully completed in all patients without severe acute or late complications. Three patients (15%) showed moderate pneumomediastinum and pneumoperitoneum, which was successfully managed by abdominal needle drainage during the procedure. One patient showed mild pleural collection, and in one patient the clip-endoloop technique was used to successfully close the mucosal entry after the completion of POEM. The outcome was uneventful without any further clinical consequences. No other short- or long-term serious complications were reported. Patients were discharged after 1-3 days of hospitalization. Six months to 3 years after the POEM procedure, all patients were alive; the majority (90%) had complete clinical improvement, while two patients with sigmoid-type achalasia showed moderate-to-significant clinical improvement. Erosive esophagitis was reported in 15%. Our results are in accordance with international data, and proved the safety and efficacy of the POEM technique for radical long-term treatment of all

  19. Formidling af praksisforløbet på Modul 12

    DEFF Research Database (Denmark)

    2013-01-01

    De studerende skal efter endt praksisforløb udarbejde et blogindlæg, som kommenteres af 3 andre medstuderendes grupper, samt vejleder. Dette materiale skal anvendes som baggrund for deres modulprøve på modul 12......De studerende skal efter endt praksisforløb udarbejde et blogindlæg, som kommenteres af 3 andre medstuderendes grupper, samt vejleder. Dette materiale skal anvendes som baggrund for deres modulprøve på modul 12...

  20. Stadig usikkerhed om skat på bitcoin

    DEFF Research Database (Denmark)

    Kjærsgaard, Louise Fjord; Weber, Katja Dyppel

    2018-01-01

    Kronik. Reglerne om skat på bitcoin er lidt klarere efter afgørelse i Skatterådet, men det er på tide at se på en ændring af de forældede regler.......Kronik. Reglerne om skat på bitcoin er lidt klarere efter afgørelse i Skatterådet, men det er på tide at se på en ændring af de forældede regler....

  1. Dyrkning af GMO-afgrøder er ikke problemfrit

    DEFF Research Database (Denmark)

    Streibig, Jens Carl

    2012-01-01

    Middtvesten i USA oplever efter 16 år med GMO-afgrøder stigende problemer med resistent ukrudt - en udvikling der måske også kan ramme danske landmænd med de nye pesticidafgifter......Middtvesten i USA oplever efter 16 år med GMO-afgrøder stigende problemer med resistent ukrudt - en udvikling der måske også kan ramme danske landmænd med de nye pesticidafgifter...

  2. Brasiliens Arbejderparti giver op

    DEFF Research Database (Denmark)

    Damgaard, Mads

    2016-01-01

    Efter 13 år måtte Brasiliens præsident Dilma Rousseff i maj 2016 udlevere nøglerne til præsidentpaladset til ventrum-højrepartiet PMDB (Partido do Movimento Democrático Brasileiro)......Efter 13 år måtte Brasiliens præsident Dilma Rousseff i maj 2016 udlevere nøglerne til præsidentpaladset til ventrum-højrepartiet PMDB (Partido do Movimento Democrático Brasileiro)...

  3. NATO 1949-2009: Fra regional forsvarsorganisation til global militær aktør

    DEFF Research Database (Denmark)

    Villaume, Poul

    2009-01-01

    Baggrunden for Atlantpagtens oprettelse, NATOs formative periode i 1950erne, 'out-of-area'-operationer i Den Tredje Verden, atomstrategier, afspændingsperioden, den kolde krigs afslutning, samt NATOs transformation og udvidelse efter 1991 tematiseres i en oversigtlig analyse.......Baggrunden for Atlantpagtens oprettelse, NATOs formative periode i 1950erne, 'out-of-area'-operationer i Den Tredje Verden, atomstrategier, afspændingsperioden, den kolde krigs afslutning, samt NATOs transformation og udvidelse efter 1991 tematiseres i en oversigtlig analyse....

  4. Efter mindfulness

    DEFF Research Database (Denmark)

    Stjernholm, Ole; Ehrensvärd, Martin Gustaf

    Tematiserer nogle af de udfordringer, der møder dig, som regelmæssigt praktiserer mindfulness og kommer med bud på, hvad bevidsthedens vaner og mønstre betyder for dybden af stilhed - og hvordan man kan arbejde med den viden.......Tematiserer nogle af de udfordringer, der møder dig, som regelmæssigt praktiserer mindfulness og kommer med bud på, hvad bevidsthedens vaner og mønstre betyder for dybden af stilhed - og hvordan man kan arbejde med den viden....

  5. The Imitation Game: Alan Turings enigmatiske imitationsspil

    DEFF Research Database (Denmark)

    Bentzen, Martin Mose

    2015-01-01

    Alan Turing revolutionerede computervidenskaben og modtog først verdens anerkendelse længe efter sin død. Nu sætter filmen 'The Imitation Game', der har premiere i Danmark 29. januar 2015, fokus på det oversete geni.......Alan Turing revolutionerede computervidenskaben og modtog først verdens anerkendelse længe efter sin død. Nu sætter filmen 'The Imitation Game', der har premiere i Danmark 29. januar 2015, fokus på det oversete geni....

  6. Velkommen til produktionsuniversitetet

    DEFF Research Database (Denmark)

    Rosenbaum, Philip

    2015-01-01

    Universitetet er blevet en fabrik, der spytter forskning og elever ud i et sort hul til ære for ranglister og dimittendstatistikker. Tilbage står forvirrede og stressede forskere og elever, der desperate halser efter misforstået effektivitetskrav.......Universitetet er blevet en fabrik, der spytter forskning og elever ud i et sort hul til ære for ranglister og dimittendstatistikker. Tilbage står forvirrede og stressede forskere og elever, der desperate halser efter misforstået effektivitetskrav....

  7. The 1918-20 International Intervention in the Baltic Region

    DEFF Research Database (Denmark)

    Clemmesen, Michael Hesselholt

    2011-01-01

    Den britisk-ledede intervention i Baltikum efter Første Verdenskrig minder på afgørende punkter om indsatsen på Balkan samt senere i Irak og Afghanistan. Men operationerne fik afgørende succes på ét år......Den britisk-ledede intervention i Baltikum efter Første Verdenskrig minder på afgørende punkter om indsatsen på Balkan samt senere i Irak og Afghanistan. Men operationerne fik afgørende succes på ét år...

  8. Kend dig selv - og dine omgivelser: Et værktøj for danske slagteriselskaber

    DEFF Research Database (Denmark)

    Skytte, Hans

    , at det ikke er tilstrækkeligt at analysere de traditionelle områder, men at det også er nødvendigt at se på udviklingen af de socialt konstruerede forståelser (bl.a. af virksomheden selv, dens kunder etc.), som opbygges i virksomhederne, og som ligger bag en virksomheds strukturer, produkter og...... omgivelser. Endvidere er tilgangen karakteriseret ved, at der i projektet hverken er søgt efter enkeltindividers opfattelser eller efter generelle sandheder, men efter de opfattelser og 'sandheder', som man udvikler i den enkelte virksomhed og i den enkelte sektor. De citater, der kommer fra interviewede...... personer i tilknytning til denne undersøgelse, og som er anført i denne rapport, skal ikke blot forstås som en subjektiv beskrivelse af produkterne, virksomhederne, markedet eller konkurrencesituationen osv., men derimod som en gengivelse af den måde ledelsen i den enkelte virksomhed - ud fra virksomhedens...

  9. Kompetenceudvikling integreret i jobfunktionen - en beskrivelse af ideen bag og metoden til videnoverførsel fra universitetet kombineret med læring på jobbet

    Directory of Open Access Journals (Sweden)

    Flemming Fink

    2006-05-01

    Full Text Available Første gang publiceret i UNEV nr. 8: Tilrettelæggelse af efter- og videreuddannelse på universitetet, nov. 2006, red. Sanne Almeborg og Tom Nyvang.
    ISSN 1603-5518.

    Tilrettelæggelse af efter- og videreuddannelse på universitetsniveau har traditionelt været betragtet som en opgave på lige fod med planlægning af kurser for studerende. Den traditionelle forståelse har været, at man engang imellem havde godt af at komme en tur ”tilbage på skolebænken”. Denne artikel beskriver en anden måde at tænke efter- og videreuddannelse på, hvor der tages udgangspunkt i kravene til ny viden fra jobfunktionen, hvor arbejdspladsens behov vægtes mindst ligeså højst som den lærendes personlige behov. Artiklen bygger på flere års erfaring fra ingeniørernes arbejdsområde, fra såvel store som små virksomheder.

  10. Socioeconomic position and contact to general practice among persons with diabetes

    DEFF Research Database (Denmark)

    Dalsgaard, Else-Marie; Vedsted, Peter; Fenger-Grøn, Morten

    2012-01-01

    Det er velkendt at der er social gradient i prognosen for diabetes, men det er uklart on denne ulighed også gælder brug af almen praksis blandt personer med diabetes. En nationalt, populationsbaseret kohortestudie blev udført med 137.492 personer med incident diabetes i alderen 40-79 år og 687...... efter diagnose blev sammenlignet. Personer med diabetes havde 4,8 (95%CI:4,7-4,8) flere konsultationer i almen praksis første år efter diagnose. Denne ekstra konsultationsrate steg med faldende SEP; f.eks. 5,8 (95%CI: 5.6-6.0) for kvinder i aldersgruppen 40-54 år med laveste uddannelsesniveau og 4,9 (95......%CI: 4,7-5,1) for kvinder med det højeste uddannelsesniveau. Personer med diabetes havde næsten 5 ekstra konsultationer i almen praksis første år efter diagnoses og antallet var højest for de med lavest SEP....

  11. Ole Bjørn Kraft 1893-1980

    DEFF Research Database (Denmark)

    Skov, Christian Houlberg

    2010-01-01

    Ole Bjørn Kraft (1893-1980) var en central konservativ politiker i årene før og efter anden verdenskrig. Han markerede sig som udpræget idépolitiker og opnåede ad flere omgange at blive minister.......Ole Bjørn Kraft (1893-1980) var en central konservativ politiker i årene før og efter anden verdenskrig. Han markerede sig som udpræget idépolitiker og opnåede ad flere omgange at blive minister....

  12. 4 hovedproblemer med STU

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2012-01-01

    Kommentaren oplister fire hovedproblemer ved den Særligt Tilrettelagte Ungdomsuddannelse, nemlig (1) beskrivelsen af målgruppen, (2) de unges forsørgelsesgrundlag, (3) hvad der følger efter én afsluttet STU, og (4) "lovjunglen" - manglende samspil mellem mange lovgivninger.......Kommentaren oplister fire hovedproblemer ved den Særligt Tilrettelagte Ungdomsuddannelse, nemlig (1) beskrivelsen af målgruppen, (2) de unges forsørgelsesgrundlag, (3) hvad der følger efter én afsluttet STU, og (4) "lovjunglen" - manglende samspil mellem mange lovgivninger....

  13. Systematic Review and Meta-Analysis of Perioperative Outcomes of Peroral Endoscopic Myotomy (POEM) and Laparoscopic Heller Myotomy (LHM) for Achalasia.

    Science.gov (United States)

    Awaiz, Aiman; Yunus, Rossita M; Khan, Shahjahan; Memon, Breda; Memon, Muhammed A

    2017-06-01

    Laparoscopic Heller myotomy (LHM) is the preferred surgical method for treating achalasia. However, peroral endoscopic myotomy (POEM) is providing good short-term results. The objective of this systematic review and meta-analysis was to compare the safety and efficacy of LHM and POEM. A search of PubMed, Cochrane database, Medline, Embase, Science Citation Index, and current contents for English-language articles comparing LHM and POEM between 2007 and 2016 was performed. Variables analyzed included prior endoscopic treatment, prior medical treatment, prior Heller myotomy, operative time, overall complications rate, postoperative gastroesophageal reflux disease (GERD), length of hospital stay, postoperative pain score, and long-term GERD. Seven trials consisting of 483 (LHM=250, POEM=233) patients were analyzed. Preoperative variables, for example, prior endoscopic treatment [odds ratio (OR), 1.32; 95% confidence interval (CI), 0.23-4.61; P=0.96], prior medical treatment [weighted mean difference (WMD), 1.22; 95% CI, 0.52-2.88; P=0.65], and prior Heller myotomy (WMD, 0.47; 95% CI, 0.13-1.67; P=0.25) were comparable. Operative time was 26.28 minutes, nonsignificantly longer for LHM (WMD, 26.28; 95% CI, -11.20 to 63.70; P=0.17). There was a comparable overall complication rate (OR, 1.25; 95% CI, 0.56-2.77; P=0.59), postoperative GERD rate (OR, 1.27; 95% CI, 0.70-2.30; P=0.44), length of hospital stay (WMD, 0.30; 95% CI, -0.24 to 0.85; P=0.28), postoperative pain score (WMD, -0.26; 95% CI, -1.58 to 1.06; P=0.70), and long-term GERD (WMD, 1.06; 95% CI, 0.27-4.1; P=0.08) for both procedures. There was a significantly higher short-term clinical treatment failure rate for LHM (OR, 9.82; 95% CI, 2.06-46.80; P<0.01). POEM compares favorably to LHM for achalasia treatment in short-term perioperative outcomes. However, there was a significantly higher clinical treatment failure rate for LHM on short-term postoperative follow-up. Presently long-term postoperative follow

  14. Dansen om nøgenheden

    DEFF Research Database (Denmark)

    Andersen, Tem Frank

    2015-01-01

    "50 ÅR EFTER har vi naturligvis rykket os noget på det punkt, hvad de kønspolitiske debatter viser. Er man hyppig bruger af Instagram, bliver det hurtigt klart, at vores kultur, i dette årtusinde, stadig har mange bøfler."......"50 ÅR EFTER har vi naturligvis rykket os noget på det punkt, hvad de kønspolitiske debatter viser. Er man hyppig bruger af Instagram, bliver det hurtigt klart, at vores kultur, i dette årtusinde, stadig har mange bøfler."...

  15. USA sender Able og Baker en tur i rummet

    DEFF Research Database (Denmark)

    Alstrup, Aage Kristian Olsen

    2014-01-01

    DETTE ER DEN TREDJE ARTIKEL I SERIEN OM DYRENES ROLLE I RUMFORSKNINGEN. VI SKAL MØDE DE TO PRIMATER ABLE OG BAKER, SOM NASA SUCCESFULDT SENDTE EN TUR I RUMMET I MAJ 1959 – HALVANDET ÅR EFTER, AT SOVJETUNIONEN HAVDE SENDT HUNDEN LAIKA DERUD.......DETTE ER DEN TREDJE ARTIKEL I SERIEN OM DYRENES ROLLE I RUMFORSKNINGEN. VI SKAL MØDE DE TO PRIMATER ABLE OG BAKER, SOM NASA SUCCESFULDT SENDTE EN TUR I RUMMET I MAJ 1959 – HALVANDET ÅR EFTER, AT SOVJETUNIONEN HAVDE SENDT HUNDEN LAIKA DERUD....

  16. Trepartsforhandlinger i Danmark og Europa følges ikke ad

    DEFF Research Database (Denmark)

    Mailand, Mikkel

    2016-01-01

    Trepartsforhandlinger med flere emner på dagsordenen flore-rede særligt i 1990’erne og tidligt i 00’erne rundt omkring i Europa, hvor de var fraværende i Danmark. Efter den øko-nomiske krise synes billedet at være vendt.......Trepartsforhandlinger med flere emner på dagsordenen flore-rede særligt i 1990’erne og tidligt i 00’erne rundt omkring i Europa, hvor de var fraværende i Danmark. Efter den øko-nomiske krise synes billedet at være vendt....

  17. Frisættelse af fødderne

    DEFF Research Database (Denmark)

    Kirkeby, Ole Fogh

    2013-01-01

    Kropskultur. Amerikansk journalist og forfatter hævder, at løb - og fødder - giver adgang til livets mening. Anmeldelse af: Christoffer McDougall: Født til løb. Oversat af Jacob Giese efter Born to Run. Forlaget Turbulenz, 400 sider.......Kropskultur. Amerikansk journalist og forfatter hævder, at løb - og fødder - giver adgang til livets mening. Anmeldelse af: Christoffer McDougall: Født til løb. Oversat af Jacob Giese efter Born to Run. Forlaget Turbulenz, 400 sider....

  18. Som i et spejl - Hans Egede-receptionen gennem tre hundrede år

    DEFF Research Database (Denmark)

    Kjærgaard, Kathrine

    2008-01-01

    stor, og længe ville man ikke vide af Hans Egede, der - skønt født i Norge - opfattedes som dansk. Først efter 1945, hvor Norge i kølvandet på Danskehjælpen under Anden Verdenskrig omsider forsonede sig med Danmark, tog man atter Hans Egede til sig. Blandt større mindesmærker, som er blevet til siden...... 1945, kan nævnes Nicolai Schiølls ungdommelige statue af grønlandsmissionæren i det centrale Oslo (1965) og Axel Revolds monumentale udskmykning af kirken i Hans Egedes nordnorske fødeby Harstad (1958). I Danmark, hvor sorgen over tabet af Norge var stor, var man i årene efter 1814 meget...... tilbageholdende med at omklamre tidligere norske landsmænd som Hans Egede. Først hen mod slutningen af 1800-tallet begyndte forbeholdene at smelte et efter et. Den definitive omdefinering af den dansk-norske 1700-tals patriot til national dansk kirkefyrste kom med opstillingen 1913 af hans statue ved Marmorkirken...

  19. Et nationalt studie af bankrøveri

    DEFF Research Database (Denmark)

    Hansen, Maj; Elklit, Ask

    11,1 % (n = 41) af ASD og seks måneder efter røveriet led 6,2 % (n = 23) af PTSD. Begge prævalenser var begrænset af kravet om undgåelsessymptomer (ASD uden undgåelse: 14 %, PTSD uden undgåelse: 17,8 %), men ASD diagnosen var især begrænset af kravet om dissociationssymptomer (ASD uden dissociation......: 26,7 %). Hierarkisk regressionsanalyse viste, at 51 % af variansen i PTSD sværhedsgrad blev forklaret af peritraumatisk dissociation, ASD sværhedsgrad, emotionel coping og negative tanker om egen person og evner. ASD sværhedsgrad var den stærkeste prædiktorer for PTSD sværhedsgrad og forudsagde alene...... diagnoser. Særligt ASD sværhedsgrad og negative tanker om egen person og evner synes at kunne forudsige PTSD sværhedsgrad efter bankrøveri. Det anbefales derfor, at ”Acute Stress Disorder Scale” anvendes til at screene for PTSD efter bankrøveri. Fremtidig forskning anbefales at fokusere på udvikling af...

  20. Opfyldelsesværnetinget for løsørekøb i europæisk ret

    DEFF Research Database (Denmark)

    Steensgaard, Kasper

    2012-01-01

    Med indførelsen af Bruxelles I-forordningen skete der et afgørende skift i reguleringen og fortolkningen af opfyldelsesværneting i europæisk procesret. I køb af løsøre og tjenesteydelser skal stedet for opfyldelse i procesretlig henseende nu fastlægges efter en autonom EU-retlig regel. Efter en...... årrække med usikkerhed om, hvilken retsstilling den nye regel medførte, har EU-domstolen med afgørelsen i Car Trim v KeySafety Systems forsøgt at komme med en afklaring - det er imidlertid kun lykkedes delvist....

  1. Fusion og koncentration i den danske svineslagterisektor

    DEFF Research Database (Denmark)

    Hansen, Henning Otte

    2015-01-01

    Strukturudviklingen i den danske slagterisektor er gået hurtig i de seneste ti-år. Koncentrationen steg kraftigt efter midten af 1980‘erne, men i de sidste 10-15 år er udviklingen i et vist omfang stagneret eller endog vendt, og koncentrationen har været faldende. En evt. fusion mellem Danish Crown...... og Tican vil sandsynligvis ikke opveje dette fald i koncentration. De historiske erfaringer fra sektoren viser endvidere, at virksomheder efter en fusion ofte taber markedsandele. Markedet for svinekød er blevet langt mere internationaliseret i de senere år, og dette alene vil øge konkurrencen....

  2. Ebolaudbruddet kan dræbe mange flere end de smittede

    DEFF Research Database (Denmark)

    Østergaard, Lise Rosendal

    2014-01-01

    Udbruddets voldsomhed kræver et her og nu-fokus på at stoppe smittekæden, men efter flere års arbejde med og forskning i sundhedssystemer i Vestafrika er det mindst lige så bekymret med de langsigtede konsekvenser af udbruddet. Ebola risikerer at underminere befolkningens tillid til sundhedssyste......Udbruddets voldsomhed kræver et her og nu-fokus på at stoppe smittekæden, men efter flere års arbejde med og forskning i sundhedssystemer i Vestafrika er det mindst lige så bekymret med de langsigtede konsekvenser af udbruddet. Ebola risikerer at underminere befolkningens tillid til...

  3. Hälsofrämjande fysisk aktivitet hos personer under adjuvant cancerbehandling relaterad till fatigue, livskvalitet samt self-efficacy

    OpenAIRE

    Zetterlund, Johanna

    2016-01-01

    Bakgrund Cancerdrabbade lider ofta av cancerrelaterad fatigue (CRF) och försämrad livskvalitet under och efter behandling. Hälsofrämjande fysisk aktivitet (HFA) kan minska risken för dessa negativa konsekvenser. HFA påverkas bl.a. av träningsrelaterad self-efficacy, dvs tilltron till egen förmåga att vara fysisk aktiv. Syfte Att undersöka HFA hos personer under adjuvant cancerbehandling vid diagnos och efter sex månader samt att undersöka om de med en stabil HFA hade lägre CRF, högre livskval...

  4. Voluntary organized sport in Denmark and Norway

    DEFF Research Database (Denmark)

    Ibsen, Bjarne; Seippel, Ørnulf

    2010-01-01

    Idræt organiseret i frivillige foreninger er meget udbredt i de skandinaviske lande. I denne artikel sammenlignes idræt i foreninger i Norge og Danmark. De to lande sammenlignes på en række dimensioner: den frivillige sektor generelt og frivillig organiseret sport specifikt. Efter denne sammenlig......Idræt organiseret i frivillige foreninger er meget udbredt i de skandinaviske lande. I denne artikel sammenlignes idræt i foreninger i Norge og Danmark. De to lande sammenlignes på en række dimensioner: den frivillige sektor generelt og frivillig organiseret sport specifikt. Efter denne...

  5. Sikkerhedsbestemmelser for beskæringsarbejde fra lift

    DEFF Research Database (Denmark)

    Jakobsen, Ole Sejr; Theilby, Frans

    2010-01-01

    Brug af lift til beskæring og fældning af træer er blevet udbredt i den grønne sektor. Som bruger er det vigtigt at kende den lift, man har valgt, og at arbejdet med motorsav foregår efter Arbejdstilsynets regler og anbefalinger.......Brug af lift til beskæring og fældning af træer er blevet udbredt i den grønne sektor. Som bruger er det vigtigt at kende den lift, man har valgt, og at arbejdet med motorsav foregår efter Arbejdstilsynets regler og anbefalinger....

  6. Surveillance of hospital-acquired infections in women having undergone caesarean section in the County of Aarhus

    DEFF Research Database (Denmark)

    Leth, Rita Andersen

    informationer fra både elektroniske databaser, medicinske journaler samt fra kvindernes selvudfyldte spørgeskemaer. Formålene med studierne var at undersøge: 1) kejsersnit som en risikofaktor for postpartum bakteriæmi (BSI), urinvejsinfektion (UVI) og postoperativ sårinfektion (PSI) sammenlignet med vaginal...... kejsersnit i forhold til vaginal fødsel, dels en øget infektionsrisiko efter akut kejsersnit i forhold til elektivt kejsersnit. Fedme og Type 1 diabetes er risikofaktorer for infektion efter kejsersnit og kombinationen af overvægt og diabetes øger risikoen for infektion yderligere. En elektronisk overvågning...

  7. Исследование острой и хронической токсичности препарата «Декасан»

    OpenAIRE

    Derkach, N. M.; Shtrygol’, S. Yu.; Laryanovska, Yu. B.; Grashenkova, S. A.

    2016-01-01

    The intestinal diseases of bacterial aetiology are characterized by high prevalence and a severe course, especially at a young age, concomitant immunity suppression or chronic diseases of the gastrointestinal system. Therefore, it is expedient to search for the new antimicrobial drugs, and it seems promising to use known antimicrobial agent decamethoxinum for the development of peroral medicinal forms, such as “Decasan” that is 0.02% decamethoxinum solution for peroral use worked out by “Yuri...

  8. Marxismen efter Marx

    DEFF Research Database (Denmark)

    Karl Marx har fået momentum oven på finanskrisen som kritiker af kapitalismen. Men i Marx og i den marxistiske tradition findes en en teoretisk dybde og analysekraft, der rækker langt ud over den nuværende krise. Karl Marx har både som medspiller og modspiller været inspirationskilde for en lang ...

  9. Efter cochlear implant

    DEFF Research Database (Denmark)

    Højen, Anders

    Dit barn har netop fået et cochlear implant. Hvad nu? Skal barnet fokusere udelukkende på at lære talt sprog, eller skal det også lære/fortsætte med tegnsprog eller støttetegn? Det er et vanskeligt spørgsmål, og før valget foretages, er det vigtigt at vurdere hvilke konsekvenser valget har, dels...... for den sproglige udvikling isoleret set, og dels for barnets udvikling ud fra en helhedsbetragtning. Dette indlæg fokuserer på, hvilke forventninger man kan have til cochlear implant-brugeres sproglige udvikling med talt sprog alene, hhv. med to sprog (tale og tegn). Disse forventninger er baseret på...

  10. Kompartmentsyndrom efter hugormebid

    DEFF Research Database (Denmark)

    Roed, Casper; Bayer, Lasse; Lebech, Anne-Mette Kjaer

    2009-01-01

    Bites from the adder, Vipera Berus, can have serious clinical consequences due to systemic effects. Meanwhile, the local swelling calls for attention as well. Two cases of seven- and eleven-year-old boys are reported. The first patient was bitten in the 5th toe, the second in the thumb. Both...... developed fasciotomy-requiring compartment syndrome of the lower and upper limb, respectively. Recognition of this most seldom complication of an adder bite is vital to save the limb. We recommend that the classical signs and symptoms of compartment syndrome serve as indication for surgery. However...

  11. Urinvejsproblemer efter ketaminmisbrug

    DEFF Research Database (Denmark)

    Reinhardt, Susanne; Fode, Mikkel

    2014-01-01

    Ketamine is gaining popularity among Danish drug users. We present the first three reports of ketamine-induced urinary symptoms in Denmark. The patients were 22-27 years old and were all referred to urological departments due to microscopic or macroscopic haematuria. In addition, all three patien...... reported pain from the penis and the gut, respectively. No specific pathology was found and all patients admitted to ketamine abuse. The cases illustrate that Danish physicians must be aware of potential side effects to ketamine abuse.......Ketamine is gaining popularity among Danish drug users. We present the first three reports of ketamine-induced urinary symptoms in Denmark. The patients were 22-27 years old and were all referred to urological departments due to microscopic or macroscopic haematuria. In addition, all three patients...

  12. Kompartmentsyndrom efter hugormebid

    DEFF Research Database (Denmark)

    Roed, Casper; Bayer, Lasse Razga; Lebech, Anne-Mette Kjaer

    2009-01-01

    developed fasciotomy-requiring compartment syndrome of the lower and upper limb, respectively. Recognition of this most seldom complication of an adder bite is vital to save the limb. We recommend that the classical signs and symptoms of compartment syndrome serve as indication for surgery. However...

  13. Hypofyseinsufficiens efter hovedtraumer

    DEFF Research Database (Denmark)

    Klose, Marianne C; Juul, Anders; Poulsgaard, Lars

    2007-01-01

    Brain injury following head trauma is a potential cause of acquired hypopituitarism, although regarded as uncommon. Consequently, such patients do not routinely undergo neuroendocrine evaluation. Recent data suggest hypopituitarism to be more common than previously stated, with a prevalence...... of at least 25% in long-term survivors. As untreated hypopituitarism is likely to delay recovery and rehabilitation, this calls for a change in the current management of patients suffering traumatic brain injury. In this article, we will review current knowledge in this field....

  14. Rekonvalescens efter kejsersnit

    DEFF Research Database (Denmark)

    Sharif, Heidi; Glavind, Julie; Uldbjerg, Niels

    2009-01-01

    Recommendations for reconvalescence and restriction of physical activity after elective caesarean section are not consistent and there is a lack of evidence on the subject. Although physiological changes are rapidly normalized after the operation, the women experience an extended period character...

  15. Concurrent myotomy and tunneling after establishment of a half tunnel instead of myotomy after establishment of a full tunnel: a more efficient method of peroral endoscopic myotomy.

    Science.gov (United States)

    Philips, George M; Dacha, Sunil; Keilin, Steve A; Willingham, Field F; Cai, Qiang

    2016-04-01

    Peroral endoscopic myotomy (POEM) is a time-consuming and challenging procedure. Traditionally, the myotomy is done after the submucosal tunnel has been completed. Starting the myotomy earlier, after submucosal tunneling is half completed (concurrent myotomy and tunneling), may be more efficient. This study aims to assess if the method of concurrent myotomy and tunneling may decrease the procedural time and be efficacious. This is a retrospective case series of patients who underwent modified POEM (concurrent myotomy and tunneling) or traditional POEM at a tertiary care medical center. Modified POEM or traditional POEM was performed at the discretion of the endoscopist in patients presenting with achalasia. The total procedural duration, myotomy duration, myotomy length, and time per unit length of myotomy were recorded for both modified and traditional POEM. Modified POEM was performed in 6 patients whose mean age (± standard deviation [SD]) was 58 ± 13.3 years. Of these, 5 patients had type II achalasia and 1 patient had esophageal dysmotility. The mean Eckardt score (± SD) before the procedure was 8.8 ± 1.3. The modified technique was performed in 47 ± 8 minutes, with 6 ± 1 minutes required per centimeter of myotomy and 3 ± 1 minutes required per centimeter of submucosal space. The Eckardt score was 3 ± 1.1 at 1 month and 3 ± 2.5 at 3 months. The procedure time for modified POEM was significantly shorter than that for traditional POEM. Modified POEM with short submucosal tunneling may be more efficient than traditional POEM with long submucosal tunneling, and outcomes may be equivalent over short-term follow-up. Long-term data and randomized controlled studies are needed to compare the clinical efficacy of modified POEM with that of the traditional method.

  16. Jeg Er blevet FRANKofil

    DEFF Research Database (Denmark)

    Andersson, Lasse

    2014-01-01

    afhængig af Frank Underwood fra serien House of Cards på den fremadstormende TV-streamingstjenesten Netflix. Jeg har opdaget et nyt internetbaseret datingforhold. Et surrealt, fedt miks af det kyniske og joviale personificeret i karakteren Frank Underwood, som er helt igennem ubehagelig, men fantastisk...... spillet af Kevin Spacey. Og tak til Spacey der for en tid har forladt teateret ’The Old Vic’ i London for at begejstre mig. Der er generelt to årsager til mine FRANKofile tilbøjeligheder. For det første er Netflix’s remake af den tyve år gamle BBC serie House of Cards efter min menig et stykke tv...... anden grund, til at jeg er blevet Frankofil, er, at jeg ikke skal sidde og vente på næste søndag efter søndag efter søndag for at få lov at se næste afsnit. Netflix lagde alle tretten timer af sæson 2 ud på nettet. Jeg afgør selv, hvornår jeg skal have mere Frank! Men på trods af mit narkomanlignende...

  17. Evaluering af en sygeplejestyret hjertesvigtsklinik

    DEFF Research Database (Denmark)

    Streym, Súsanna við

    2008-01-01

    den helbredsrelaterede livskvalitet målt ved hjælp af Minnesota Living with Heart Failure Questionnaire (MLHF) ved baseline og efter der minimum var gået 10 uger. Genindlæggelseshyppigheden og gennemsnitsindlæggelsestiden, blev målt ved at sammenligne alle førstegangsindlæggelser fra 1. marts 2006 til...... tilbuddet om fysisk træning, ville have taget imod det (n=18). Konklusion: Den helbredsrelaterede livskvalitet var signifikant forbedret efter opfølgende undersøgelse. Dog kan dette studie ikke påvise, eksakt hvilke interventioner der har haft indflydelse på forbedringen. Der er ingen forskel på...

  18. Den danske samfundsudvikling 1848-2012 og marxistisk, neoklassisk, keynesiansk, monetaristisk og nykeynesiansk teori

    DEFF Research Database (Denmark)

    Madsen, Poul Thøis

    Efter i adskillige år at have undervist ud fra andres bøger og efter mange tilløb besluttede forfatteren sig for at skrive sin egen forskningsbaserede bog til Det Samfundsvidenskabelige Fællessemester, som dækker fem lektioner om den politiske økonomis historie og den danske økonomiske udvikling........ Ambitionen har været at udarbejde en kort appetitvækker, der gør, at studerende får et overblik og forstår nogle basale sammenhænge og får lyst til at vide mere om økonomisk teori, dansk og international økonomi og ikke mindst debatterne herom....

  19. Krigsvidenskaben er endt i en blindgyde

    DEFF Research Database (Denmark)

    Clemmesen, Michael Hesselholt

    2015-01-01

    I 1914 fejlede krigsvidenskaben. Derefter anvendte man krigen og årtierne efter til at udvikle våbensystemer og taktik, der kunne genskabe muligheden for afgørende krig. Under og efter Den Kolde Krig videreudvikledes disse våbensystemer, men blev senest kun anskaffet i meget lille antal pga. pris....... prisudviklingen pr. enhed. Det var intet problem når modstanderen ikke havde sådanne våben, men med Ruslands udfordring af verdensordenen kan de massive tab, der altid finder sted i en større krig mellem jævnbyrdige, har Vestens valg igen ført til en krigsvidenskabelig blindgyde....

  20. Ad industriens Vej

    DEFF Research Database (Denmark)

    Nielsen, Leif Hansen

    2007-01-01

    Før 1864 var Slesvig og Holstens industri i vækst, og hertugdømmerne var foregangsområder for industrien i det danske monarki. Det ændrede sig efter Slesvig og Holstens indlemmelse i Preussen i 1867. Generelt ramtes industrien af tilbagegang, da konkurrencen fra den tyske industri blev mærkbar. I...... store byer som Altona, Neumünster, Kiel og Flensborg samt i Hamborgs nordlige opland fortsatte industrialiseringen dog efter en kort overgangsperiode med fornyet kraft. De mindre byer, herunder de nordslesvigske købstæder Haderslev, Aabenraa, Sønderborg og Tønder, stor derimod ligesom landområderne...

  1. Europæisk offentlighed i danske medier

    DEFF Research Database (Denmark)

    Ørsten, Mark

    2006-01-01

    Nyere forskning viser, at en europæisk offentlighed er under udviklingen. Graden af europæisering er dog forskellig fra land til land. Men en ting er undersøgelserne enige om: Danske medier ligger i front, når det gælder europæisering. Udgivelsesdato: efterår......Nyere forskning viser, at en europæisk offentlighed er under udviklingen. Graden af europæisering er dog forskellig fra land til land. Men en ting er undersøgelserne enige om: Danske medier ligger i front, når det gælder europæisering. Udgivelsesdato: efterår...

  2. Long-term patency of experimental magnetic compression gastroenteric anastomoses achieved with covered stents.

    Science.gov (United States)

    Cope, C; Ginsberg, G G

    2001-06-01

    Our aim was to evaluate the efficacy of a prototype "YO-YO"-shaped covered stent for keeping experimental magnetic compression gastroenteric fistulas patent for 6 months. Magnets were introduced perorally with endoscopic and fluoroscopic guidance and were mated across the gastric and jejunal walls of 5 dogs. After a mean of 5.5 days a 12-mm diameter YO-YO stent was placed perorally in the resulting fistula. The gastroenteric anastomosis (GEA) with stent was observed endoscopically and gastrographically at 1- to 2-month intervals. There was no morbidity and there were no significant weight changes. The GEA was widely patent at necropsy at 6 months (n = 4); partial membrane separation occurred at 5 months in the fifth dog. There was minor breakage of the stent prongs in 2 animals. Peroral creation of a stented magnetic compression GEA is safe and provides long-term patency. This technique may be potentially useful for managing gastric outlet obstruction caused by malignancy.

  3. Reduced postoperative pain scores and narcotic use favor per-oral endoscopic myotomy over laparoscopic Heller myotomy.

    Science.gov (United States)

    Docimo, Salvatore; Mathew, Abraham; Shope, Alexander J; Winder, Joshua S; Haluck, Randy S; Pauli, Eric M

    2017-02-01

    Per-oral endoscopic myotomy (POEM) is a less invasive therapy for achalasia with a shorter hospitalization but with similar short- and long-term outcomes as a laparoscopic Heller myotomy (LHM). Previous literature comparing POEM to LHM has focused primarily on postoperative outcome parameters such as complications, dysphagia scores and gastro-esophageal reflux severity. This study specifically compares postoperative pain following POEM to pain following LHM, the current gold-standard operation. A retrospective review of all patients undergoing POEM or LHM for achalasia was performed from 2006 to 2015. Data collection included demographics, comorbidities, length of stay (LOS) and pain scores (arrival to the recovery room, 1 h postoperative, average first 24 h and upon discharge). Statistical analysis was performed using Student's t test and Chi-square test. Forty-four POEM patients and 122 LHM patients were identified. The average age (52.2 ± 20.75 vs 50.9 ± 17.89 years, p = 0.306) and BMI (28.1 ± 7.62 vs 27.6 ± 7.07 kg/m 2 , p = 0.824) did not differ between the POEM and LHM groups, respectively; however, the American Society of Anesthesiology scores were higher in the POEM patients (2.43 ± 0.62 vs 2.11 ± 0.71, p = 0.011). There were no differences in rates of smoking, diabetes, cardiac disease or pulmonary disease. The average pain scores upon arrival to the recovery room and 1 h postoperatively were lower in the POEM group (2.3 ± 3.014 vs 3.61 ± 3 0.418, p = 0.025 and 2.2 ± 2.579 vs 3.46 ± 3.063, p = 0.034, respectively). There was no difference in the average pain score over the first 24 h (2.7 ± 2.067 vs 3.29 ± 1.980, p = 0.472) or at the time of discharge (1.6 ± 2.420 vs 2.09 ± 2.157, p = 0.0657) between the POEM and LHM groups. After standardizing opioid administration against 10 mg of oral morphine, the POEM group used significantly less narcotics that the LHM group (35.8 vs 101.8 mg, p < 0

  4. Identitetsonani

    DEFF Research Database (Denmark)

    Hougaard, Anders

    2015-01-01

    Jagten på identitet fordrer endeløse selvmanifestationer. Men de hjælper os ikke til at kaste anker i omverdenen; vi bumper bare ind i den i forsøget på at finde os selv. I længden bliver det tomt, og så tager længslen efter fællesskab til......Jagten på identitet fordrer endeløse selvmanifestationer. Men de hjælper os ikke til at kaste anker i omverdenen; vi bumper bare ind i den i forsøget på at finde os selv. I længden bliver det tomt, og så tager længslen efter fællesskab til...

  5. To GIF or not to GIF

    DEFF Research Database (Denmark)

    Konzack, Lars

    2013-01-01

    Oxford Dictionary kårede ”to GIF” som årets ord i 2012. Efter at animerede GIF’s i en årrække blev anset for dårlig smag, er de nu inde i varmen igen. Og de giver nye muligheder for at kommunikere gennem et levende, klart og præcist billedsprog.......Oxford Dictionary kårede ”to GIF” som årets ord i 2012. Efter at animerede GIF’s i en årrække blev anset for dårlig smag, er de nu inde i varmen igen. Og de giver nye muligheder for at kommunikere gennem et levende, klart og præcist billedsprog....

  6. Esophageal bypass after failed chemoradiotherapy for unresectable esophageal cancer

    International Nuclear Information System (INIS)

    Matono, Satoru; Tanaka, Toshiaki; Mori, Naoki; Nagano, Takeshi; Fujita, Hiromasa; Shirouzu, Kazuo

    2013-01-01

    Esophageal stenosis and/or fistula often occur after chemoradiotherapy (CRT) for unresectable esophageal cancer. In such patients, an esophageal stent can help achieve oral intake. However an esophageal stent cannot be inserted where there is complete stenosis or where the tumor is located. In such cases, esophageal bypass surgery may be necessary. Here, we investigated the clinical characteristics and outcomes in patients who underwent esophageal bypass surgery in our institution. We reviewed 10 cases of esophageal bypass surgery (gastric tube in 8 cases, colon in 2 cases) after CRT for unresectable esophageal cancer, between 2001 and 2009. There were 5 of stenosis-only cases, 4 fistula-only cases, and 1 case of stenosis and fistula. There were postoperative complications in 5 cases (50%), and all these were treated conservatively and healed. The median survival from surgery to peroral intake was 20 days (range 9-90 days), and the median survival after starting peroral intake was 130 days (range 48-293 days). Esophageal bypass surgery can achieve good performance status and improve peroral intake. (author)

  7. From POEM to POET: Applications and perspectives for submucosal tunnel endoscopy.

    Science.gov (United States)

    Chiu, Philip W Y; Inoue, Haruhiro; Rösch, Thomas

    2016-12-01

    Recent advances in submucosal endoscopy have unlocked a new horizon for potential development in diagnostic and therapeutic endoscopy. Increasing evidence has demonstrated that peroral endoscopic myotomy (POEM) is not only clinically feasible and safe, but also has excellent results in symptomatic relief of achalasia. The success of submucosal endoscopy in performance of tumor resection has confirmed the potential of this new area in diagnostic and therapeutic endoscopy. This article reviews the current applications and evidence, from POEM to peroral endoscopic tunnel resection (POET), while exploring the possible future clinical applications in this field. © Georg Thieme Verlag KG Stuttgart · New York.

  8. The SUP Proposal

    DEFF Research Database (Denmark)

    Hansen, Jesper Lau

    2015-01-01

    Baseret på en konference om Kommissionens forslag til et ny direktiv om enkeltmandsejede private selskaber (SUP) beskriver artiklen reglerne om registrering og kapital for et SUP efter det opr. forslag....

  9. Media in Post-Communist Mongolia – challenges and opportunities in the democratization process

    DEFF Research Database (Denmark)

    Nielsen, Poul Erik

    2009-01-01

    En analyse af mediernes indflydelse på demokratiseringsprocessen i Mongoliet efter kommunismens afvikling. Analysen fokuserer på de problemer der er knyttet til introduktionen af et nyt liberalistisk mediesystem. Udgivelsesdato: November 2009...

  10. Klavikelduplikation efter traumatisk klavikelepifysiolyse

    DEFF Research Database (Denmark)

    Pedersen, Lasse; Frich, Lars Henrik

    2009-01-01

    A case of a 15-year-old boy with an injury to the distal clavicle resulting in a "banana peel lesion" and subsequent formation of a "neoclavicle" in the empty periostal sleeve is presented and discussed. Udgivelsesdato: Aug-17......A case of a 15-year-old boy with an injury to the distal clavicle resulting in a "banana peel lesion" and subsequent formation of a "neoclavicle" in the empty periostal sleeve is presented and discussed. Udgivelsesdato: Aug-17...

  11. Posttraumatisk stress efter arbejdsulykker

    DEFF Research Database (Denmark)

    Rasmussen, K; Lauritsen, Jens; Hansen, O N

    1999-01-01

    This study focuses on post-traumatic stress disorder in a follow up one to two years after the occupational accident. The aim was to estimate the prevalence of PTSD, changes in general health status and issues of compensation. The material was all serious accidents registered in the Danish National...... Register of Work Accidents during 1991. Seriousness was defined by type of injury, including all cases of amputations, bone fractures and extensive body lesions. Of 4745 possible, 3663 persons (77%) participated in a questionnaire study. The prevalence fulfilling the complete set of criteria...... of posttraumatic stress disorder as a chronic state was 2.8% (102 persons), of whom half had been given compensation. Among the most severe accidents the prevalence was 7.6%. In conclusion, in a large cohort of persons with moderate and severe occupational injuries this study demonstrated that post...

  12. Terapeutisk hypotermi efter hjertestop

    DEFF Research Database (Denmark)

    Larsen, Louise Pape; Kristensen, Klaus Veng; Kirkegaard, Hans

    2009-01-01

    INTRODUCTION: The objective of the present paper was to examine the association between cerebral status at discharge in patients treated with therapeutic hypothermia (TH) and: 1) time form collapse to initiation of TH, 2) time form collapse to target temperature (32-34 degrees C), 3) time from in...

  13. Posttraumatisk stress efter arbejdsulykker

    DEFF Research Database (Denmark)

    Rasmussen, K; Lauritsen, Jens; Hansen, O N

    1999-01-01

    This study focuses on post-traumatic stress disorder in a follow up one to two years after the occupational accident. The aim was to estimate the prevalence of PTSD, changes in general health status and issues of compensation. The material was all serious accidents registered in the Danish National...... of posttraumatic stress disorder as a chronic state was 2.8% (102 persons), of whom half had been given compensation. Among the most severe accidents the prevalence was 7.6%. In conclusion, in a large cohort of persons with moderate and severe occupational injuries this study demonstrated that post......-traumatic stress disorder and lasting psychological distress should be a matter for concern in addition to the physical injury....

  14. Graviditet efter bariatrisk kirurgi

    DEFF Research Database (Denmark)

    Kjær, Mette Mandrup; Torvin-Andersen, Lise Lotte; Dam, Peter

    2018-01-01

    This is a review of the recommendations regarding pregnancy after bariatric surgery from the Danish Society of Obstetrics and Gynaecology. The risk of vitamin/mineral deficiencies should be emphasized and checked with blood samples. Measurements of fetal growth should be offered at gestational ag...

  15. Graviditet efter bariatrisk kirurgi

    DEFF Research Database (Denmark)

    Kjær, Mette Mandrup; Torvin-Andersen, Lise Lotte; Dam, Peter

    2017-01-01

    This is a review of the recommendations regarding pregnancy after bariatric surgery from the Danish Society of Obstetrics and Gynaecology. The risk of vitamin/mineral deficiencies should be emphasized and checked with blood samples. Measurements of fetal growth should be offered at gestational ag...

  16. Graviditet efter bariatrisk kirurgi

    DEFF Research Database (Denmark)

    Renault, Kristina Martha; Andersen, Lise Lotte Torvin; Kjær, Mette Karie Mandrup

    2012-01-01

    In the latest years the number of pregnant women having undergone bariatric surgery before pregnancy has increased rapidly. In pregnancy, they seem to have a reduced risk of obesity-related complications but an increased risk of mechanical complications causing small bowel obstruction and complic...

  17. Neonatale konsekvenser efter vakuumekstraktion

    DEFF Research Database (Denmark)

    Nielsen, Mathilde Maagaard; Sørensen, Jette Led; Lando, Ane

    2010-01-01

    About 5000 babies annually, or 1/12 of all births, are the result of vacuum-assisted delivery in Denmark. Towards the end of the 1990'ies, the US FDA published a national warning concerning increasing complications and mortality after vacuum-assisted delivery, and other countries followed. One ex...

  18. Intrauterin graviditet efter Cavatermbehandling

    DEFF Research Database (Denmark)

    Shokouh-Amiri, Ali; Kjaergaard, Niels

    2009-01-01

    A case of intrauterine pregnancy occurring after successful balloon thermal endometrial ablation is described. Although rare, pregnancy after endometrial ablation is possible, and use of a supplemental contraceptive method should be planned. In case of pregnancy after endometrial ablation...

  19. På jagt efter relationen

    DEFF Research Database (Denmark)

    Wind, G.

    2001-01-01

    Denne artikel viser, at patient-sygeplejerskerelationen ikke bare er der. Først i det øjeblik der fokuseres på relationen, skabes den og bliver til en betydningsbærende instans. I første del af artiklen ses der på, hvorledes relationen anskues ud fra en medicinsk antropologisk synsvinkel for sene...

  20. Hvad leder vi efter?

    DEFF Research Database (Denmark)

    Luth, Edda Merete

    2010-01-01

    administration continuously interferes and changes decisions made on a lower level. This type of management creates pressure and makes prioritizing difficult for heads in the public sector, but it also potentially leads to more development. Evidence-based science is important in the development of social work...... analysis is to make it possible to understand the relations, positions, battles and institutional conditions constituting management in social work. The theoretical construct will set out explicitly the position of the researcher in the field and the researcher's focus on his/her own assumptions during...... a specific discoursive practice can help establishing certain values as a definition of truth concerning the field 'social work'. The heads of social work departments, who participated in the survey, generally found their work both interesting, challenging and demanding. Finally the process concentrates...

  1. Akut kulilteforgiftning efter vandpiberygning

    DEFF Research Database (Denmark)

    Paulsen, Jakob Felbo; Villads, Kasper von Rosen; Sonne, Morten

    2016-01-01

    Carbon monoxide poisoning is potentially lethal, and early recognition and treatment is essential. An 18-year-old man was admitted due to syncope and a carboxyhaemoglobin level of 17% after water pipe tobacco smoking. He received normo- and hyperbaric oxygen as treatment and was discharged after...

  2. Neonatale konsekvenser efter vakuumekstraktion

    DEFF Research Database (Denmark)

    Nielsen, Mathilde Maagaard; Sørensen, Jette Led; Lando, Ane

    2010-01-01

    About 5000 babies annually, or 1/12 of all births, are the result of vacuum-assisted delivery in Denmark. Towards the end of the 1990'ies, the US FDA published a national warning concerning increasing complications and mortality after vacuum-assisted delivery, and other countries followed. One...

  3. Neonatale konsekvenser efter vakuumekstraktion

    DEFF Research Database (Denmark)

    Nielsen, Mathilde Maagaard; Sørensen, Jette Led; Lando, Ane

    2010-01-01

    explanation is that training is no longer given the needed focus. Recent introduction of new requirements on Danish specialist training and the fact that vacuum-assisted delivery is an important procedure in obstetrics provides the basis for this article which systematically reviews the neonate consequences...

  4. Genoptraening efter total knaealloplastik

    DEFF Research Database (Denmark)

    Holm, Bente; Kehlet, Henrik

    2009-01-01

    The short- and long-term benefits of post-discharge physiotherapy regimens after total knee arthroplasty are debatable. A national survey including hospitals in Denmark that perform total knee arthroplasty showed a large variability in indication and regimen for post-knee arthroplasty...

  5. Genoptraening efter total knaealloplastik

    DEFF Research Database (Denmark)

    Holm, Bente; Kehlet, Henrik

    2009-01-01

    The short- and long-term benefits of post-discharge physiotherapy regimens after total knee arthroplasty are debatable. A national survey including hospitals in Denmark that perform total knee arthroplasty showed a large variability in indication and regimen for post-knee arthroplasty rehabilitat......The short- and long-term benefits of post-discharge physiotherapy regimens after total knee arthroplasty are debatable. A national survey including hospitals in Denmark that perform total knee arthroplasty showed a large variability in indication and regimen for post-knee arthroplasty...... rehabilitation. Since hospital stay duration has decreased considerably, the need for post-discharge physiotherapy may also have changed. Thus, the indication for and types of rehabilitation programmes need to be studied within the context of fast-track knee arthroplasty....

  6. Genoptraening efter total knaealloplastik

    DEFF Research Database (Denmark)

    Holm, Bente; Kehlet, Henrik

    2009-01-01

    The short- and long-term benefits of post-discharge physiotherapy regimens after total knee arthroplasty are debatable. A national survey including hospitals in Denmark that perform total knee arthroplasty showed a large variability in indication and regimen for post-knee arthroplasty rehabilitat......The short- and long-term benefits of post-discharge physiotherapy regimens after total knee arthroplasty are debatable. A national survey including hospitals in Denmark that perform total knee arthroplasty showed a large variability in indication and regimen for post-knee arthroplasty...... rehabilitation. Since hospital stay duration has decreased considerably, the need for post-discharge physiotherapy may also have changed. Thus, the indication for and types of rehabilitation programmes need to be studied within the context of fast-track knee arthroplasty. Udgivelsesdato: 2009-Feb-23...

  7. Synergistic interactions between paracetamol and oxcarbazepine in somatic and visceral pain models in rodents.

    Science.gov (United States)

    Tomić, Maja A; Vucković, Sonja M; Stepanović-Petrović, Radica M; Ugresić, Nenad D; Prostran, Milica S; Bosković, Bogdan

    2010-04-01

    Combination therapy is a valid approach in pain treatment, in which a reduction of doses could reduce side effects and still achieve optimal analgesia. We examined the effects of coadministered paracetamol, a widely used non-opioid analgesic, and oxcarbazepine, a relatively novel anticonvulsant with analgesic properties, in a rat model of paw inflammatory hyperalgesia and in a mice model of visceral pain and determined the type of interaction between components. The effects of paracetamol, oxcarbazepine, and their combinations were examined in carrageenan-induced (0.1 mL, 1%) paw inflammatory hyperalgesia in rats and in an acetic acid-induced (10 mg/kg, 0.75%) writhing test in mice. In both models, drugs were coadministered in fixed-dose fractions of the 50% effective dose (ED(50)), and type of interaction was determined by isobolographic analysis. Paracetamol (50-200 mg/kg peroral), oxcarbazepine (40-160 mg/kg peroral), and their combination (1/8, 1/4, 1/3, and 1/2 of a single drug ED(50)) produced a significant, dose-dependent antihyperalgesia in carrageenan-injected rats. In the writhing test in mice, paracetamol (60-180 mg/kg peroral), oxcarbazepine (20-80 mg/kg peroral), and their combination (1/16, 1/8, 1/4, and 1/2 of a single drug ED(50)) significantly and dose dependently reduced the number of writhes. In both models, isobolographic analysis revealed a significant synergistic interaction between paracetamol and oxcarbazepine, with a >4-fold reduction of doses of both drugs in combination, compared with single drugs ED(50). The synergistic interaction between paracetamol and oxcarbazepine provides new information about combination pain treatment and should be explored further in patients, especially with somatic and/or visceral pain.

  8. Seminarren.dk

    DEFF Research Database (Denmark)

    Højer-Pedersen, Lasse; Rask, Gitte

    2013-01-01

    Valg af materiale/medie/form: Hjemmeside Valg af arbejdsform: Udvikling og opsætning Begrundelse for valg af materiale/medie/form/arbejdsform: Målgruppens præference, efter mange år med et studenterblad....

  9. To See or not to See

    DEFF Research Database (Denmark)

    Simonsen, Karen-Margrethe

    2011-01-01

    Artiklen handler om overvågningstemaet i moderne kunst med særlig fokus på Hasan Elahis netbaserede kunstværk "Tracking Transience". Elahi blev kort efter 9/11 anholdt mistænkt for terror. Siden den tid har han overvåget sit liv og 24 timer i døgnet kan man følge hans liv på nettet.Artiklen analy......Artiklen handler om overvågningstemaet i moderne kunst med særlig fokus på Hasan Elahis netbaserede kunstværk "Tracking Transience". Elahi blev kort efter 9/11 anholdt mistænkt for terror. Siden den tid har han overvåget sit liv og 24 timer i døgnet kan man følge hans liv på nettet...

  10. Regulering af jagt på vandfugle i kystzonen: Forsøg med dato-regulering på Nyord

    DEFF Research Database (Denmark)

    Bregnballe, T.; Hounisen, J. P.; Bøgebjerg, E.

    Et 4-årigt forsøg udført på Nyord Sydeng ved Møn har vist at jagt med 1-3 ugers interval ikke påvirkede antallet af gæs, ænder og vadefugle negativt, bort set fra at enkelte arter (især jagtbare arter) optrådte i lavere antal dagen efter en jagt. Fuglenes adfærdsmæssige reaktion på udøvelse af ja...... samt effekten på fuglenes antal var mindst i et år hvor engene blev oversvømmet tidligt på efteråret. Det konkluderes at dato-regulering af jagt på strandenge kan være et velegnet værktøj hvis der skal findes et alternativ til total jagtfredning...

  11. Pharmacokinetic evaluation of pamidronate after oral administration: a study on dose proportionality, absolute bioavailability, and effect of repeated administration

    DEFF Research Database (Denmark)

    Hyldstrup, Lars; Flesch, G; Hauffe, S A

    1993-01-01

    30 minutes at constant infusion rate. Repeated peroral doses (75 and 150 mg) were administered to 12 females (aged 51-70 years) for 10 consecutive days. Urinary excretion of pamidronate after peroral and i.v. administration was used for estimation of pamidronate absorption. Renal excretion...... of pamidronate ranged from 0.01% to 0.35% of dose, with mean values of 0.11, 0.16, and 0.18% for 75, 150, and 300 mg, respectively. After i.v. infusion, the renal excretion of pamidronate was 26-53% of the dose, lower than for other bisphosphonates. The absolute bioavailability was 0.31% (range 0.08-0.7%) after...

  12. Nykælvere mangler protein

    DEFF Research Database (Denmark)

    Dalbach, Kristine Foged; Larsen, Mogens; Kristensen, Niels Bastian

    2010-01-01

    Ny forskning fra DJF viser, at køer er i væsentligt proteinunderskud lige efter kælvning. Dette kan have negative konsekvenser for koens evne til fx at vedligeholde immunforsvaret. Udgivelsesdato: Juni...

  13. "Orange Juice" - amerikansk agent og dansk patriot?

    DEFF Research Database (Denmark)

    Hansen, Peer Henrik

    2009-01-01

    Umiddelbart efter anden verdenskrig indledte den amerikanske efterretningstjeneste Office of Strategic Service (OSS) samarbejde med en række danske politikere og modstands- og efterretningsfolk. En af dem var Svend Truelsen, en af modstandskampens store helte...

  14. Drawing Disaster

    DEFF Research Database (Denmark)

    Borggreen, Gunhild

    2015-01-01

    En analyse af den japanske manga Santetsu i relation til vidnesbyrdbeskrivelse og erindring under genopbygning efter det store jordskælv i det østlige Japan i 2011, herunder diskussion af tegning i relation til fotografi...

  15. The programme of measures of the water framework directive – more than just a formal compliance tool

    DEFF Research Database (Denmark)

    Baaner, Lasse

    2011-01-01

    Artiklen analyserer kravene til indsatsprogrammerne efter vandrammedirektivet. Der identificeres fire slags bestemmelser: bestemmelser om foranstaltninger for at nå direktivets miljømål, bestemmelser om foranstaltninger med hensyn til andre forpligtelser i vandrammedirektivet, bestemmelser om for...

  16. Efek Toksisitas Ekstrak Daun Sirih Merah Terhadap Gambaran Mikroskopis Ginjal Tikus Putih Diabetik yang Diinduksi Aloksan

    Directory of Open Access Journals (Sweden)

    Ni Made Rina Yulinta

    2013-08-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui efek toksik dari ekstrak daun sirih merah terhadap gambaran mikroskopis ginjal tikus putih diabetes mellitus yang diinduksi aloksan. Sebanyak 20 ekor tikus putih jantan galur Sprague-dawley umur ± 3 bulan digunakan dalam penelitian ini. Seluruh sampel tersebut dibagi secara acak menjadi lima kelompok perlakuan yaitu: (P0 tikus sehat yang hanya diberikan aquades; (P1 tikus yang diberikan aloksan 120 mg/kg bb/intraperitoneal; (P2 tikus yang diberikan aloksan 120 mg/kg bb/intraperitoneal dan ekstrak daun sirih merah 50 mg/kg bb/peroral; (P3 tikus yang diberikan aloksan 120 mg/kg bb/intraperitoneal dan ekstrak daun sirih merah 100mg/kg bb/peroral; (P4 tikus yang diberikan aloksan 120mg/kg bb/intraperitoneal dan suspensi glibenklamid 1 mg/kgbb/peroral. Perlakuan diberikan selama 30 hari. Pada hari ke-31 semua tikus dieuthanasi dan dinekropsi untuk melihat gambaran mikroskopis ginjal. Hasil penelitian menunjukkan bahwa pemberian ekstrak daun sirih merah (Piper crocatum dosis 50 mg/kg bb dan 100 mg/kg bb tidak menunjukkan perubahan patologi terhadap gambaran mikroskopis ginjal. Hal ini menunjukkan ekstrak daun sirih merah dosis 50 mg/kgbb dan dosis 100 mg/kgbb tidak toksik terhadap jaringan ginjal tikus putih diabetes mellitus.

  17. Christmas Stars

    DEFF Research Database (Denmark)

    Andersen, Niels John

    2010-01-01

    Matematiklærere er som regel altid på jagt efter emner og aktiviteter, der kan engagere, fascinere og udfordre eleverne på mange niveauer. At udforske og eksperimentere med design af stjerneformede polyedre er en af de mange muligheder....

  18. Visitors to Nicopolis in the reigns of Augustus and Ali Pacha

    DEFF Research Database (Denmark)

    Isager, Jacob

    2007-01-01

    Nicopolis, grundlagt af kejser Augustus, efter slaget ved Actium (i 31. f.Kr.) i samtidens litteratur samt i rejselitteraturen fra begyndelsen af 1800-tallet og de ideologiske og moralske overvejelser, som antikkens og 1800-tallets forfattere har gjort sig....

  19. Recension af Lin Prøitz Selvbilde: Fra selvportet til #selfie

    DEFF Research Database (Denmark)

    Fausing, Bent

    2017-01-01

    Anmeldelse af katalog til udstilling om selfies i Oslo i 2016-2017. Anmeldelsen er koncentreret omkring tilgangen til selfies, som via koncentrationen om litteratur efter 2015 og omkring narcissisme forfejler sit mål og reducerer selfiens betydningsområder....

  20. Disruption fra øst

    DEFF Research Database (Denmark)

    Hartelius, Anne Mette

    2017-01-01

    Efter en uge i 'Det vilde Østen' med alle sanser indstillet på østerlandsk æstetik kan man godt få den tanke, at vi alle har brug for designdisruption herhjemme i vores postmodernistiske vestlige del af verden....

  1. Koncernbegreber i regnskabs- og selskabsretten - et studium i koncernbegrebers tilblivelse og indhold med baggrund i samspillet mellem internationale regnskabsstandarder, EU-retten og national ret

    DEFF Research Database (Denmark)

    Sørensen, Anne Birgitte Søgaard

    Siden 2005 har europæiske børsnoterede selskaber skullet aflægge koncernregnskaber efter IASB-organisationens regnskabsstandarder, og siden 2009-reformerne af henholdsvis årsregnskabsloven og selskabsloven har disse loves koncernbegreber skullet fortolkes i overensstemmelse hermed. Dette rejser en...

  2. Peroral endoscopic myotomy for achalasia

    NARCIS (Netherlands)

    Bredenoord, A. J.; Rösch, T.; Fockens, P.

    2014-01-01

    Treatment of achalasia is complicated by symptom recurrence and a significant risk for severe complications. Endoscopic myotomy was developed in the search for a highly efficacious treatment with lower risks. Since its introduction in 2010, several centers have adopted the technique and published

  3. Stars og striber

    DEFF Research Database (Denmark)

    Ørum, Tania

    2010-01-01

    Dansk (og nordisk) eksperimenterende kunst efter 2.verdenskrig sammenholdt med udviklingen i USA. Der er ikke blot tale om indflydelse fra amerikansk kunst til dansk, men i lige så høj grad om en selvstændig udvikling i Danmark....

  4. Continuing Vocational Training (CVT) and Life Long Learning (LLL) - Policy Recommendations and Reflections

    DEFF Research Database (Denmark)

    Hansen, Leif Emil

    En sammenfattende rapport over et EU-finansieret projekt med kritiske refleksioner og anbefalinger vedrørende en øget deltagelse i livslang læring og erhvervsrettet efter- og videreuddannelse i de 4 partnerlande Bulgarien, Danmark, Grækenland og Rumænien...

  5. Sociologi

    DEFF Research Database (Denmark)

    Sandholm, Niels

    2016-01-01

    I kapitlet diskuteres ud fra et sociologisk perspektiv brug af et screeningsinstrumentet til opsporing af depression efter indlæggelse for hjertesygdom. HADS – Hospital Anxiety and Depression Scale Det er en udbredt praksis at screene udskrevne hjertepatienter for depression. Som screeningsinstru...

  6. Karl Marx 1864 og forsigtighedsprincippet

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf

    2015-01-01

    Artiklen analyserer divergerende versioner af den tekst, som Karl Marx efter dannelsen af den 1.Internationale Arbejderassociation i London september 1864 har oversat fra sit engelske original (Inaugural Address...), der udkom i november, til en tysk version med overskriften 'Manifest an die...

  7. Det teoretiske grundlag for en relationel psykiatri (kap. 2)

    DEFF Research Database (Denmark)

    Jacobsen, Claus Haugaard; Kjølbye, Morten

    2009-01-01

      Efter en kort indledning, hvor dynamisk psykiatri defineres, gennemgås dens historiske udgangspunkt i klassisk psykoanalytisk teori. Dette udgangspunkt kritiseres, hvorefter fokus bliver rettet mod et senere og mere moderne teoretiske grundlag for en dynamisk og relationel psykiatri. Dette find...

  8. Asbestholdige materialer i bygninger

    DEFF Research Database (Denmark)

    Wormslev, E.C.; Prebensen, K.

    Anvisningen er et katalog over asbestholdige materialer. Efter en kort vejledning om identifikation af asbestholdige materialer, bringes katalogblade over en lang række produkter eller produktnavne, producent eller importør, anvendelsesområde, anvendelsesperiode, og så vidt muligt oplysninger om...

  9. Terrorbekæmpelse og menneskerettigheder

    DEFF Research Database (Denmark)

    Rytter, Jens Elo

    2008-01-01

    Artiklen undersøger Danmarks rolle som USA's koalitionspartner  i krigen i Afghanistan, som fulgte efter terrorangrebene den 11. september 2001. Artiklen konkluderer, at Danmark overtrådte folkeretten ved at overføre tilfangetagne personer til amerikanske styrker, eftersom USA's politik...

  10. Koncernbegrebet

    DEFF Research Database (Denmark)

    Sørensen, Anne Birgitte Søgaard

    Siden 2005 har europæiske børsnoterede selskaber skullet aflægge koncernregnskaber efter IASB-organisationens regnskabsstandarder, og siden 2009-reformerne af den danske årsregnskabslov og den danske selskabslov har disse loves koncernbegreber skullet fortolkes i overensstemmelse hermed. Bogen...

  11. The potential for reductive dechlorination after thermal treatment of TCE-contaminated aquifers

    DEFF Research Database (Denmark)

    Friis, Anne Kirketerp

    Klorerede opløsningsmidler som fx triklorethen (TCE) er en alvorlig kilde til jord- og grundvandsforurening. Der er kun ganske få afværgeteknikker, der er effektive i området tæt på kilden til forureningen, og en af de mest anvendelige er termisk oprensning, hvor undergrunden opvarmes, så...... elektrisk opvarmning (ERH) i felten, var der bakterier som overlevede i eller blev transporteret til det opvarmede område med grundvandet. Disse bakterier kunne delvist nedbryde TCE (til cDCE) og bibeholdt redoxforhold efter opvarmningen, der kun var lidt mindre favorable for dechlorering i forhold til...... bioaugmenteret ved tilførsel af organisk stof og en mikrobiel blandingskultur med deklorerende bakterier. Bioaugmentationen førte til deklorering af TCE til ethen både i laboratorieopvarmede samt in-situ-opvarmede sedimenter. Dette faktum har påvist et potentiale og behov for bioaugmentation efter ERH...

  12. Dokumenterede metoder i bostøtteindsatsen over for mennesker med psykiske lidelser

    DEFF Research Database (Denmark)

    Amilon, Anna; Mehlsen, Line; Bengtsson, Steen

    , som kan bistå borgeren efter forløbets afslutning. Konklusion/resultater: Overordnet set viser evalueringen, at borgerne profiterer af CTI-indsatsen. Der sker en statistisk signifikant forbedring af CTI-gruppens mentale trivsel fra første måling til 9-måneders-målingen. Borgernes funktionsniveau er...... blevet målt på tre livsområder: arbejde/uddannelse, socialt liv og familieliv/hjemlige forpligtelser. Resultaterne viser, at borgerne udvikler sig signifikant i positiv retning (oplever færre begrænsninger) efter 9 måneders forløb sammenholdt med ved forløbets opstart. Derudover viser resultaterne fra....... Indsatsborgerne oplevede forbedret psykisk trivsel, forbedret funktionsevne samt fik et stærkere socialt netværk. Baggrund: Evalueringen af metoden Critical Time Intervention (CTI), er udarbejdet som led i satspuljeinitiativet ’Dokumenterede metoder i bostøtteindsatsen over for mennesker med psykiske lidelser...

  13. Pohled laiků, lékařů a pacientů na novou metodu léčby achalázie (POEM) - dotazníková studie

    Czech Academy of Sciences Publication Activity Database

    Walterová, B.; Doležel, R.; Ryska, O.; Juhásová, Jana; Juhás, Štefan; Stefanová, M.; Špičák, J.; Martínek, J.

    2014-01-01

    Roč. 68, č. 4 (2014), s. 288-293 ISSN 1804-7874 Institutional support: RVO:67985904 Keywords : esophageal achalasia * peroral endoscopic myotomy * laparoscopic myotomy Subject RIV: FP - Other Medical Disciplines

  14. Biodegradation of xenobiotic organic compounds in wastewater treatment plants

    DEFF Research Database (Denmark)

    Press-Kristensen, Kåre

    analysemetode til simultan ekstraktion og måling af modelstofferne i komplekse spildevandsmatricer. Det blev klarlagt hvilke procesparametre, der skal justeres ved optimering af renseanlæggene. Dette arbejde forventes forsat efter projektets afslutning. Perspektivet er en model for nedbrydning af miljøfremmede...

  15. Socialt entreprenørskab på RUC

    DEFF Research Database (Denmark)

    ; Social Impact Measurement and finding a balance between academic criteria and professional relevance. Helle Hygum Espersen: At kvalificere samskabelses-dagsordenen i en kommune - overvejelser over mulige afgørende principper. Stine Skov Øllgård Efter-videreuddannelsesstrukturer – et afgørende parameter...

  16. Skolerne på reformarbejde

    DEFF Research Database (Denmark)

    Humle, Didde Maria

    2016-01-01

    Skolerne arbejder i disse år med at leve op til de nye krav i skolereformen. Men det er ikke så enkelt at omsætte reformen til praksis, viser et projekt, der har fulgt en række skoler i tiden efter reformen....

  17. Landbruget og kulturlandskabet

    DEFF Research Database (Denmark)

    Rentz-Petersen, Nee

    2011-01-01

    Denne historiske oversigt beskriver, hvordan landbrugets bygninger og driftsformer gennem de sidste 6000 år har tilført kulturlandskabet en dynamik og stadig forvandling. Materialet er udvalgt efter nedslagsmetoden – landbrugets udvikling beskrives i spring, når signifikante ændringer og nyskabel...

  18. Fat teknologien

    DEFF Research Database (Denmark)

    I 2013-2015 har alle UCSJ’s professionsuddannelser, efter- og videreuddannelserne og Forskning og Innovation gennemført VIOL-projektet i samarbejde med Roskilde Universitet. Her er gennem forskningsbaseret uddannelsesudvikling blevet sat fokus på, hvordan den velfærdsteknologiske udvikling påvirk...

  19. Memento - Christian Lemmerz

    DEFF Research Database (Denmark)

    Sørensen, Ann Lumbye

    Monografien om Christian Lemmerz omhandler kunstnerens skulpturer og installationsværker med inddragelse af performances og film. Bogen er inddelt efter materialevalg, idet de valgte materialer indikerer arten af udsagn, som kunstneren artikulerer virkningsæstetisk vedrørende eksistens, krop og død...

  20. Edward Said

    DEFF Research Database (Denmark)

    Botofte, John; Jensen, Lars

    En gennemgang af Edward Saids forfatterskab. Skønt gennemgangen er relativt kronologisk, er det en hovedpointe med bogen at vise samspillet mellem Saids mangefacetterede interesser og publikationer. Endelig indeholder bogen et bibliografiessay og et essay om arven efter Said inden for det postkol...

  1. Industriarbejdere mellem tradition og forandring

    DEFF Research Database (Denmark)

    Caraker, Emmett

    Eksisterer det klassiske arbejderkollektiv, på hvilke betingelser og hvorfor? Det er denne afhand-lings problemstilling. Undersøgelsen foregår i 2 industrivirksomheder, og i alt 80 industriarbejdere er interviewet. I den ene case møder industriarbejderne efter en virksomhedsoverdragelse ledelsens...

  2. Behandling af gener efter whiplash

    DEFF Research Database (Denmark)

    Rittig-Rasmussen, Bjarne; Kongsted, Alice; Carstensen, Tina

    2010-01-01

    Treatment of whiplash-associated disorders starts with a thorough clinical examination, which may be repeated after 1-3 weeks. For optimal results it is essential that the patient receives clear information about the condition and that any pain is treated effectively with analgesics. Risk factors...

  3. Insufficient blodtrykskontrol efter koronar revaskularisering

    DEFF Research Database (Denmark)

    Roseva-Nielsen, Natasha; Kristensen, Kjeld; Talleruphuus, Ulrik

    2009-01-01

    After coronary revascularization, anti-angina treatment is often withdrawn or reduced while the ejection fraction tends to improve. Both contribute to increase blood pressure (BP). The purpose of the present study was to evaluate BP control in patients after revascularization procedures.......After coronary revascularization, anti-angina treatment is often withdrawn or reduced while the ejection fraction tends to improve. Both contribute to increase blood pressure (BP). The purpose of the present study was to evaluate BP control in patients after revascularization procedures....

  4. Socialisme i Chile efter Pinochet

    DEFF Research Database (Denmark)

    Cristoffanini, Pablo Rolando

    2008-01-01

    Chile bliver ofte præsenteret som et paradigme for resten af det latinamerikanske kontinent: Et land med høj økonomisk vækst og politisk stabilitet. Landet har endda haft to socialistiske præsidenter siden 2000, den sidste den første kvindelige præsident. Succeshistorien har en bagside: De...... socialistiske regeringer har accepteret et begrænset demokrati og videreført en nyliberal økonomisk politik, der har bragt dem på konfrontationskurs med massebevægelserne og isoleret Chile fra de andre lande i regionen, der søger integration og gensidig støøte. Udgivelsesdato: Februar...

  5. Organisk kataton tilstand efter apopleksi

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Jørgensen, Martin Balslev

    2009-01-01

    , stereotyped movements and repetition of meaningless sounds. The condition responded to benzodiazepine and electroconvulsive therapy. Catatonia should be considered as a differential diagnosis when the described symptoms occur in patients with a known organic cerebral disorder. Udgivelsesdato: 2009-Aug-31...

  6. Bursitis efter vaccination i skulderregionen

    DEFF Research Database (Denmark)

    Bliddal, Henning; Torp-Pedersen, Søren; Falk-Riecke, Birgit

    2017-01-01

    Shoulder pain may develop after vaccination in the deltoid area due to inadvertent injection of the vaccine into the subdeltoid bursa, which may be located close to the skin. As far as we know, such vaccination reactions occur more frequently than officially registered, and doctors may not be awa...

  7. Alvorlig korneal skoldningsskade efter vanddampeksplosion

    DEFF Research Database (Denmark)

    Øregaard, Jógvan Suni; Tran, Thuy Linh; Paulsen, Jakob Felbo

    2016-01-01

    Facial burns and scalds are common but the eyes are rarely affected. We present a case of a 40-year-old female patient with severe eye injury due to facial scald. Although initial examination in the emergency department did not reveal signs of serious injury, the patient was referred to the burns...... unit two days later due to suspicion of infection of the facial burns. She was found to have seriously impaired vision and was transferred to a department of ophthalmology. Examination revealed bilateral severe corneal injuries and bilateral limbal ischaemia, presumably leading to permanently impaired...

  8. Mave-tarm-funktion efter kolecystektomi

    DEFF Research Database (Denmark)

    Rumessen, Jüri J

    2005-01-01

    Randomized studies of the physiological and clinical consequences of cholecystectomy for uncomplicated gallbladder stones are very scarce. Bile acid malabsorption is increased postoperatively, probably giving rise to diarrhea in a few sensitive individuals. Preexisting abdominal distension and fa...

  9. Laegers kliniske faerdigheder efter turnusuddannelsen

    DEFF Research Database (Denmark)

    Ringsted, Charlotte V; Pallisgaard, Jane; Falck, Geir

    2002-01-01

    INTRODUCTION: The aim of this study was to evaluate Danish interns' clinical skills after their internship in order to identify areas where systematic training is needed. This study was a follow-up of a previous study on a group of interns at the beginning of their internship. MATERIAL AND METHODS......: A questionnaire listing 88 practical skills was posted to a group of trainees before and after internship. The interns were asked to rate their level of mastery in each skill on a scale 0-10, where 0 = not mastery/not competent and 10 = mastery/competent. RESULTS: In all, 74 out of 100 trainees returned...... concern that skills particularly in emergency procedures do not improve. There is a need to define clear objectives, implement structured training programmes, and assess skills in order to accomplish a reliable and sufficient level of competency. Udgivelsesdato: 2002-Jun-10...

  10. Tejnefiskeri efter jomfruhummer. Et litteraturstudie

    DEFF Research Database (Denmark)

    Frandsen, Rikke; Krag, Ludvig Ahm; Andersen, Bo Sølgaard

    The Danish quota for Norway lobster is fished by use of trawl. In the past 5 years, between 10 and 70 % of the quota has not been exploited. This is partly on account of restricted quotas on some of the other species that are targeted in this mixed species fishery. Furthermore, in order to protect...... cod, trawling is banned in some areas including areas known as Norway lobster grounds. Creels are highly selective gears both with regards to sizes and species and they lead to high quality landings. Compared to trawling, stationary gears such as creels also have much less impact on the benthic...... habitat and reduce fuel consumption. Commercial creeling for Norway lobster is for example found in Sweden, Norway, Scotland, and the Faroe Islands. However, all available literature report low catch rates and the viability of the fishery therefore depends upon fuel savings and the opportunity to achieve...

  11. HRM i Danmark efter krisen

    DEFF Research Database (Denmark)

    Bévort, Frans; Holt Larsen, Henrik; Hjalager, Anne-Mette

    Kortlægning af praksis for Human Resource Management (HRM) i alle organisationer i Danmark med mere end 100 ansatte.......Kortlægning af praksis for Human Resource Management (HRM) i alle organisationer i Danmark med mere end 100 ansatte....

  12. Mave-tarm-funktion efter kolecystektomi

    DEFF Research Database (Denmark)

    Rumessen, Jüri J

    2005-01-01

    Randomized studies of the physiological and clinical consequences of cholecystectomy for uncomplicated gallbladder stones are very scarce. Bile acid malabsorption is increased postoperatively, probably giving rise to diarrhea in a few sensitive individuals. Preexisting abdominal distension and fa...... intolerance most often persist postoperatively. In adequately selected patients, abdominal pain may subside in 75% or more. The presence of functional bowel disease should always be considered in patients with uncomplicated gallstones....

  13. At Lede Efter Læring

    DEFF Research Database (Denmark)

    slagmark, hvor forskellige forandringsambitioner tager livtag med hinanden. Ved at relatere til Harry Potter 5 (som handler om en skolereform), Max Weber og andre interessante værker og forfattere, slår vi til lyd for at skolen må gen-politiseres. Det nytter ikke at én ideologisk dagsorden tager patent på...

  14. Stressfraktur efter epifysiodese i femur

    DEFF Research Database (Denmark)

    Al-Aubaidi, Zaid; Engell, Vilhelm; Lundgaard, Bjarne

    2010-01-01

    Growth guiding is currently widely practiced for deformity correction in the growing child. Different methods have been developed. In 2007 Stevens described a tension band device (8-plates) as a simple growth control method. Since then it has been widely used, e.g. in hemiepiphysiodesis to correct...... varus or valgus deformities or extension defect in the knee. Temporary epiphysiodesis can also be used to correct leg length discrepancy more accurately. Complications after treatment with 8-plates are well-described. Stress fracture after the usage of this device has to our knowledge not yet been...

  15. Organisk kataton tilstand efter apopleksi

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Jørgensen, Martin Balslev

    2009-01-01

    Catatonia is seen in various psychiatric disorders, but also rarely occurs in medical conditions with organic cerebral affection. We present a case of a previously mentally healthy male, who developed catatonia years after a stroke in the right hemisphere. Catatonic symptoms included stupor, mutism......, stereotyped movements and repetition of meaningless sounds. The condition responded to benzodiazepine and electroconvulsive therapy. Catatonia should be considered as a differential diagnosis when the described symptoms occur in patients with a known organic cerebral disorder. Udgivelsesdato: 2009-Aug-31...

  16. Organisk kataton tilstand efter apopleksi

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Jørgensen, Martin Balslev

    2009-01-01

    Catatonia is seen in various psychiatric disorders, but also rarely occurs in medical conditions with organic cerebral affection. We present a case of a previously mentally healthy male, who developed catatonia years after a stroke in the right hemisphere. Catatonic symptoms included stupor, mutism......, stereotyped movements and repetition of meaningless sounds. The condition responded to benzodiazepine and electroconvulsive therapy. Catatonia should be considered as a differential diagnosis when the described symptoms occur in patients with a known organic cerebral disorder. Udgivelsesdato: 2009-Aug...

  17. Angina pectoris efter sumatriptan (Imigran)

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Christiansen, B D

    1992-01-01

    Developed for the treatment of migraine, sumatriptan is an agonist of 5-hydroxytryptamine-1-receptors. Though a pressure sensation is a common complaint, significant ECG changes have not been reported after subcutaneous administration of sumatriptan. A case history is given where angina pectoris...... after sumatriptan self-administration was experienced on two occasions by a 61-year old man with a history of minor myocardial infarction--without post-infarction angina--two years previously. The angina after sumatriptan was accompanied on both occasions by significant ST-segment depression on ECG...

  18. Ældres skadestuehenvendelser efter fald

    DEFF Research Database (Denmark)

    Kirchhoff, Marianne; Bregnbak, Michael J; Backe, Hanne

    2008-01-01

    emergency departments and 444 hospital admissions (including the first admission). The contacts and admissions generated 8,310 bed-days. The six-month mortality was 13%. CONCLUSION: The results document the frailty of a considerable proportion of the elderly who contact the acute emergency department......INTRODUCTION: The aim of this retrospective study was to quantify and characterize contacts to the acute emergency department due to fall accidents among elderly aged 65 years and above at H:S Hvidovre hospital in Copenhagen during a three-month period. Data on demographics, injuries and admission...... rates were collected along with follow-up data during the six months after the index contact. MATERIAL AND METHODS: Case records from patients aged 65 years and above seen in the emergency department from July 1st to September 30th 2001 were examined. Patients with documented falls as primary cause...

  19. Abdominalfistel syv ar efter kolecystektomi

    DEFF Research Database (Denmark)

    Hougard, K.; Bergenfeldt, M.

    2008-01-01

    A 64-year old female presented with fistulas on the abdomen 7 years after laparoscopic cholecystectomy. During fistula excision, several gallstones were found. Scrutiny of the medical records revealed that spillage of gallstones had occurred during the cholecystectomy. We conclude that spilled ga...

  20. Rekonvalescens og sygemelding efter influenza

    DEFF Research Database (Denmark)

    Pedersen, Court

    2009-01-01

    four days of the illness. Convalescence from disease should be expected to comprise seven days from symptom onset. In mild cases with symptoms lasting only few days, convalescence could be limited to four days unless prevention of transmission is given very high priority. Shorter duration...

  1. Indikation for adrenalinautoinjektor efter anafylaksi

    DEFF Research Database (Denmark)

    Malling, Hans-Jørgen; Hansen, Kirsten Skamstrup; Mosbech, Holger

    2012-01-01

    Anaphylaxis is a potentially fatal hypersensitivity reaction, which should be treated with adrenaline. Patients at risk of recurrent anaphylaxis after the initial episode should be prescribed an adrenalin autoinjector. The patients include persons, who are allergic to insect venom, before...... they reach the maintenance dose of allergen-specific immunotherapy, persons with food allergy who are at risk of accidental intakes, persons with anaphylaxis induced by low-intensity physical activity, and idiopathic anaphylaxis. The recommended dose of adrenaline is 0.15 mg for children up to 20 kg and 0...

  2. Rekonvalescens og sygemelding efter kolonresektion

    DEFF Research Database (Denmark)

    Jakobsen, Dorthe Hjort; Andersen, Jens

    2009-01-01

    The benefits of fast-track surgery are improved recovery and a shorter period of postoperative convalescence. After uncomplicated colonic resection, there is no pathophysiological basis for recommending a postoperative convalescence of more than 2-3 weeks. Advice after discharge - Convalescence...

  3. Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta

    International Nuclear Information System (INIS)

    Korshunov, V.M.; Pinegin, B.V.; Mal'tsev, V.N.; Kissina, E.V.; Ikonnikova, T.B.; Goncharova, G.I.; Lyannaya, A.I.; Institut Biofiziki, Moscow; Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii)

    1980-01-01

    Mice weighing 19-20 g have been exposed to the dose of 700 R and devided into 3 groups. During the first five days animals of the first group received antibiotics perorally - 40 units phenoxypenicillin, 30 units oxytetracycline, 40 units streptomicine. On the 6th, 10th and 15th days after irradiation the bifidobacterium preparation (75-41 strain) has been introduced perorally in the amount of 5x10 8 cells. Animals of the second group have received antibiotics alone in the same period as mice of the first group but the sterile physiological solution has been introduced instead of bifidobacteria. The sterile physiological solution has been perorally introduced to animals of the third group instead of antibiotics and bifidobacteria. The complex treatment has lead to the increase of survival percentage as compared with animals which have not been treated. The normalization of the intestines microbic landscape is observed in irradiated mice, subjected to treatment with antibiotics and bifidobacteria. It is expressed in a considerable reduction in the amount of clostridium, enterococci, intestinal bacilli and proteus as compared with the amount of these microbes in the intestines of non-treated mice. At the same time, a certain increase of lactobacilli amount to the level characteristic of lactobacilli in the intestinal tract of non-treated animals is observed in the intestines of irradiated and treated mice

  4. Effect of antibiotics and bifidobacterial preparations on the intestinal microflora in mice irradiated with gamma quanta

    Energy Technology Data Exchange (ETDEWEB)

    Korshunov, V M; Pinegin, B V; Mal' tsev, V N; Kissina, E V; Ikonnikova, T B; Goncharova, G I; Lyannaya, A I [Vtoroj Moskovskij Gosudarstvennyj Meditsinskij Inst. (USSR); Institut Biofiziki, Moscow (USSR); Akademiya Meditsinskikh Nauk SSSR, Moscow. Inst. Ehpidemiologii i Mikrobiologii)

    1980-07-01

    Mice weighing 19-20 g have been exposed to the dose of 700 R and devided into 3 groups. During the first five days animals of the first group received antibiotics perorally - 40 units phenoxypenicillin, 30 units oxytetracycline, 40 units streptomicine. On the 6th, 10th and 15th days after irradiation the bifidobacterium preparation (75-41 strain) has been introduced perorally in the amount of 5x10/sup 8/ cells. Animals of the second group have received antibiotics alone in the same period as mice of the first group but the sterile physiological solution has been introduced instead of bifidobacteria. The sterile physiological solution has been perorally introduced to animals of the third group instead of antibiotics and bifidobacteria. The complex treatment has lead to the increase of survival percentage as compared with animals which have not been treated. The normalization of the intestines microbic landscape is observed in irradiated mice, subjected to treatment with antibiotics and bifidobacteria. It is expressed in a considerable reduction in the amount of clostridium, enterococci, intestinal bacilli and proteus as compared with the amount of these microbes in the intestines of non-treated mice. At the same time, a certain increase of lactobacilli amount to the level characteristic of lactobacilli in the intestinal tract of non-treated animals is observed in the intestines of irradiated and treated mice.

  5. Anette Poder: "Historiebevidsthed og kronologi. Om den røde tråd i historie", 2016

    DEFF Research Database (Denmark)

    Grevy, Carlo

    2017-01-01

    Folkeskolelærer Anette Poder fortæller i dette artikeluddrag om folkeskolens undervisning i historiekanonen (2006) på baggrund af sine observationer i folkeskoler i 2013. På de observerede skoler blev der undervist efter princippet den røde tråd, hvor forskellige historiekanonpunkter blev...

  6. Uanmodet kommunikation i sociale medier

    DEFF Research Database (Denmark)

    Trzaskowski, Jan

    2012-01-01

    henvendelser ikke omfatter beskeder i sociale medier. Indtil den 12. juni 2013 kan man i national ret opretholde en bredere definition af begrebet elektronisk post i lyset af fjernsalgsdirektivet. Herefter skal spørgsmålet om uanmodet elektronisk post i sociale medier vurderes efter handelspraksisdirektivet....

  7. Sound of Stockholm

    DEFF Research Database (Denmark)

    Groth, Sanne Krogh

    2013-01-01

    Med sine kun 4 år bag sig er Sound of Stockholm relativt ny i det internationale festival-landskab. Festivalen er efter sigende udsprunget af en større eller mindre frustration over, at den svenske eksperimentelle musikscenes forskellige foreninger og organisationer gik hinanden bedene, og...

  8. Demarcación Territorial de la Propiedad Comunal en la Costa Caribe de Nicaragua

    DEFF Research Database (Denmark)

    Bogen samler vigtige artikler om jordrettigheder på Atlanterhavskysten af Nicaragua. Efter introduktionen, der giver et overblik over alle bogens artikler, følger to kapitler der diskutere begreber vedrørende territorielle rettigheder og disses historiske base. Næste del af bogen (4 kapitler) dis...

  9. PTSD hos ældre efterladte

    DEFF Research Database (Denmark)

    O'Connor, Maja

    2009-01-01

    Intro: Tab af ægtefælle i alderdommen kan være en traumatisk begivenhed med reaktioner og symptomer på linje med dem, man nogle gange ser efter overfald, ulykker og naturkatastrofer. Det slår en ny undersøgelse fast. Udgivelsesdato: Maj 2009...

  10. Han har jo ikke noget tøj på

    DEFF Research Database (Denmark)

    Feldt, Jakob Egholm

    2013-01-01

    Siden 11. september 2001 og efter Muhammed-krisen er ’islamkritik’ gradvist blevet et accepteret begreb, som betegner kritik af islam som religion, filosofi, politik og livsform. Det er samtidig blevet en levevej for folk, som i islam ser en fascisme, der truer demokratiet, friheden og nationen...

  11. Rapport om et interventionsprojekt om integreret skriftlighed på VUC Horsens

    DEFF Research Database (Denmark)

    Hobel, Peter

    Rapporten afrapporterer et interventionsprojekt i Center for Forskning i Skoleudviklings regi. Projektet kørte fra foråret 2014 til efteråret 2015. Rapporten fremlægger projektets skriveteoretiske grundlag og analyserer cases fra forløbet. Endvidere en afsluttende diskussion og anbefalinger. Til...

  12. Rapport om et interventionsprojekt om integreret skriftlighed på Thy-Mors HF og VUC

    DEFF Research Database (Denmark)

    Hobel, Peter

    Rapporten afrapporterer et interventionsprojekt i Center for Forskning i Skoleudviklings regi. Projektet kørte fra foråret 2014 til efteråret 2015. Rapporten fremlægger projektets skriveteoretiske grundlag og analyserer cases fra forløbet. Endvidere en afsluttende diskussion og anbefalinger. Til...

  13. Forædling af nordmannsgran og nobilis:

    DEFF Research Database (Denmark)

    Nielsen, Ulrik Braüner

    Denne rapport er udarbejdet som en status efter godt 7 års forædlingsarbejde i Skov & Landskab regi indenfor træarterne nobilis og nordmannsgran. Rapporten belyser status over det hidtige forædlingsarbejde og skitserer tillige nogle fremtidige perspektiver ved en fortsat forædlingsindsats...

  14. Mark-to-Funding - En ny regnskabsregel til finanskriser?

    DEFF Research Database (Denmark)

    Thinggaard, Frank

    2010-01-01

    Kan nye regnskabsregler reducere risikoen for finans-/kreditkriser, eller kan de minimere effekterne heraf? En gruppe makro- og finansieringsøkonomer har et bud på nye regler, der efter deres mening har disse kvaliteter. Denne artikel præsenterer og vurderer de foreslåede regnskabsregler....

  15. Det indskrevne publikum i politiske kommentarer

    DEFF Research Database (Denmark)

    Bengtsson, Mette

    2016-01-01

    I denne artikel fremsættes en kritik af kommentargenren i en dansk kontekst. Med udgangspunkt i 90 kommentarartikler fra landsdækkende aviser under folketingsvalget i 2011 laves en analyse af genrens indskrevne publikum efter Edwin Blacks analyseforskrifter i tre trin: Først analyseres materialet...

  16. Muligheder for klimatilpasning i landbrugserhvervet - status og handlemuligheder. Tjele: Aarhus Universitet, Institut for Agroøkologi / Naalakkersuisut: The Government of Greenland

    DEFF Research Database (Denmark)

    Lehmann, Jesper Overgård; Sharif, Behzad; Kjeldsen, Chris

    2016-01-01

    Nærværende redegørelse er udarbejdet efter udbud fra det grønlandske selvstyre, hvor formålet var at beskrive klimaforandringernes konsekvenser for landbrugserhvervet frem mod 2050, og med det udgangspunkt at identificere konkrete tiltag for tilpasninger i erhvervet. Ud fra modelberegninger forve...

  17. Excel-ark i mudderet

    DEFF Research Database (Denmark)

    Thorsted, Thomas; Brinch Jensen, Kenneth; Grøn, Maria Christine

    2014-01-01

    Det er svært at forestille sig et mere turbulent miljø at operere i end det, som madboderne på Roskilde Festival kaster sig ud i de 10 dage, festivalen varer. Efterspørgslen er ekstremt uforudsigelig og svinger efter vejr, musikprogram og kundernes luner....

  18. Fat crystallization in dairy products

    DEFF Research Database (Denmark)

    Rønholt, Stine

    har et mere kompakt krystalnetvrk sammenlignet med AMF produkterne. Resultatet er dog anderledes hvis fraktionen af fedtdråber ændres, idet en reduceret mængde fedtdråber resulterer i høj G' (Artikel VI). Under videre opbevaring ved 5 C vil effekten af efter krystallisation dominere både mikrostruktur...... population af beta-krystaller og spor af . De undersøgte produktionsparametre påvirker dog, i alle de 28 dage undersgt, bagesmrets evne til at bevare krystalnetvrket til trods for gentagen kraft påvirkning. Både kort opholdstid og øget rotationshastighed øger bagesmørets evne til at modstå nedbrydning. Det....... Resultaterne understreger dog samtidig at efter krystallisation under efterfølgende opbevaring reducerer de indledningsvist observerede forskelle i reologiske egenskaber, mikrostruktur og krystal struktur. Fra et industrielt synspunkt betyder dette, at der er et bredt produktionsmæssigt vindue til at producere...

  19. Digital dannelse

    DEFF Research Database (Denmark)

    Bundsgaard, Jeppe

    2012-01-01

    I al vores iver efter at få presset nogle flere digitale dimser ind i skolen, er vi i fare for at glemme hvad det er vi skal med disse dimser. Der er store forventninger til at de kan gøre det lettere at være lærer (og dermed billigere), og det kan det måske. Men der er jo også et dannelsesspørgs......I al vores iver efter at få presset nogle flere digitale dimser ind i skolen, er vi i fare for at glemme hvad det er vi skal med disse dimser. Der er store forventninger til at de kan gøre det lettere at være lærer (og dermed billigere), og det kan det måske. Men der er jo også et...... dannelsesspørgsmål knyttet til it. Hvad er egentlig digital dannelse? Og hvad betyder det for danskfaget?...

  20. Gruppebaseret behandling af BED - et faseopdelt behandlingstilbud

    DEFF Research Database (Denmark)

    Laust, Jakob; Lau, Marianne Engelbrecht; Waaddegaard, Mette

    2015-01-01

    konsekvenser. BED blev i 2013 optaget i DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) som en selvstændig diagnose og BED forventes medtaget i den forestående revision af det internationale diagnose system, ICD-11. Sundhedsstyrelsen gav på denne baggrund satspuljemidler til erfaringsopsamling...... EDE-Q: 1,7 og ved EDI: 1,5), ligesom de generelle psykiske symptomer blev mindsket i høj grad (effectsize ved WHO-5: 1,0 og ved GSI meanscore: 0,8). I alt 82 % opfyldte før behandlingens start DSM-4’s diagnostiske kriterier for BED mod 11,5 % efter behandling. 52 % fik fuld remission (ingen...... accept af og tilfredshed med behandlingen. Der var stor effekt på antal overspisninger. Før behandling havde patienterne gennemsnitligt 23,7 overspisninger pr. mdr. mod 2,3 efter behandling (effect size: 5,4). Udbyttet i forhold til den samlede spiseforstyrrelsessymptomatologi var høj (effect size ved...

  1. Når vi går i drift

    DEFF Research Database (Denmark)

    Svejvig, Per

    2012-01-01

    Implementering af store forretningssystemer til CRM og ERP optager mange danske virksomheder. Denne artikel fokuserer på forandringsledelse som en meget vigtig og integreret del af den samlede implementering. Artiklen berører især tiden efter at man er gået i drift med forretningssystemet....

  2. Conjugation of Organic Molecules to DNA and Their Application in DNA Nanotechnology

    DEFF Research Database (Denmark)

    Olsen, Eva Maria

    2012-01-01

    Denne PhD afhandling præsenterer fire kapitler, som omhandler det videnskabelige område DNA nanoteknologi. Kapitel 1 er en general introduktion til DNA nanoteknologi, som først beskriver opbygningen af DNA og efter flere underkapitler slutter med en gennemgang af nogle fantastiske dynamiske DNA s...

  3. En alternativ sundhedsstrategi

    DEFF Research Database (Denmark)

    Andersen, Heidi Lene

    2016-01-01

    Hvis vi som samfund ønsker at ændre på den nuværende situation med ulighed i sundhed, må vi gøre noget anderledes og lede efter supplementer og alternativer til de nuværende sundhedsstrategier. En community health-tilgang er ét alternativ...

  4. Trafikfarlige Skoleveje - Definition og udpegning

    DEFF Research Database (Denmark)

    Madsen, Jens Chr. Overgaard; Schmidl Søbjærg, Stig; Blynning, Edith

    2008-01-01

    Rambøll Nyvig og Herning Kommune har udviklet en model til udpegning af trafikfarlige skoleveje. Modellen sikrer, at vejnettet kan beskrives og prioriteres efter, hvor det er mest farligt og utrygt for skolebørn at færdes. Modellen kan anvendes i identifikationen af befordringsberettigede elever,...

  5. Environmental and resource management

    DEFF Research Database (Denmark)

    Madsen, Henning; Ulhøi, John Parm

    1996-01-01

    Artiklen bringer bl.a. de seneste resultater (i forkortet udgave) fra et igangværende flerårigt forskningsprojekt - The Danish Environmental Management Survey (DEMS) - der sigter efter løbende at analysere og vurdere den igangværende 'forgrønnelse' i erhvervslivet i et longitudinalt perspektiv...

  6. Host response during acute canine distemper virus infections in naive and DNA immunized mink

    DEFF Research Database (Denmark)

    Nielsen, Line

    SAMMENDRAG (DANISH SUMMARY) Mink blev inokuleret med to forskellige vildtype hundesygevirus (CDV) stammer fra forskellige genotyper. DK91 stammen repræsenter de europæiske genotyper isoleret efter 1990, mens Snyder Hill stammen repræsenter de gamle amerikanske genotyper isoleret før 1960. De to C...

  7. Infiltrationsanæstesi som postoperativ smertebehandling ved hoftenær femurfraktur - et igangværende studie

    DEFF Research Database (Denmark)

    Bech, Rune Dueholm

    2008-01-01

    pertrochantær femurfraktur og collum femoris fraktur inkluderes. 50 patienter indgår i hver af de to diagnose-grupper (to delstudier). Ved randomisering tildeles patienterne hhv. Ropivacain eller placebo (NaCl), der gives som 1 peroperativ og 6 postoperative bolusinstillationer via et kateter, som fjernes efter...

  8. De mest effektive avlsplaner kan findes ved simuleringer

    DEFF Research Database (Denmark)

    Meier, Kristian; Sørensen, Anders Christian; Thirstrup, Janne Pia

    2014-01-01

    Selektion for høj pelskvalitet og store skind foregår i praksis på levende dyr, mens prisen for skindet vurderes efter pelsning. Vores analyser viste positiv men lav korrelation mellem pelskvalitetsegenskaber vurderet på henholdsvis levende dyr og skind. Ydermere fandt vi en negativ korrelation...

  9. Lav sammenhæng mellem pelskvalitet vurderet på levende dyr og skind betyder at livdyrsvurdering ikke er den bedste metode til selektion af avlsdyr

    DEFF Research Database (Denmark)

    Thirstrup, Janne Pia; Jensen, Just; Meier, Kristian

    2014-01-01

    Selektion for høj pelskvalitet og store skind foregår i praksis på levende dyr, mens prisen for skindet vurderes efter pelsning. Vores analyser viste positiv men lav korrelation mellem pelskvalitetsegenskaber vurderet på henholdsvis levende dyr og skind. Ydermere fandt vi en negativ korrelation...

  10. Symptoms as the main problem

    DEFF Research Database (Denmark)

    Rosendal, Marianne; Carlsen, Anders Helles; Rask, Mette Troellund

    2016-01-01

    Dette studie undersøger tilfredsheden hos patienter, der blev afsluttet i almen praksis uden specifik diagnose, dvs. hvor lægen efter afsluttet konsultation kun kunne anføre "symptom" eller "problem" som slutdiagnose. Det drejer sig om ca. 1/3 af alle helbredsrelaterede konsultationer i almen...

  11. Evaluering af energiklasserne 2015 og 2020 i BR10

    DEFF Research Database (Denmark)

    Knudsen, Henrik Nellemose; Kragh, Jesper

    Denne rapport er udarbejdet for Energistyrelsen med det formål at indsamle erfaringer fra de første byggerier, der er opført efter lavenergiklasse 2015 og bygningsklasse 2020 i Bygningsreglementet 2010 med henblik på at videreudvikle klasserne i det fremtidige bygningsreglement. Erfaringerne er i...

  12. Argentina and Brazil's Relations to the EU

    DEFF Research Database (Denmark)

    Christensen, Steen Fryba

    Analysen diskuterer Argentina og Brasiliens relationer til EU i nyere tid med udgangspunkt i forhandlingerne om en associeringsaftale mellem EU og Mercosur, der igangsattes efter underskrivelsen af en bi-regional rammeaftale i 1995. Fokus er i særlig grad på, hvordan disse relationer bedst forstås...

  13. Under pres for at tilgive

    DEFF Research Database (Denmark)

    Gade, Christian B.N.

    2013-01-01

    Efter afslutningen på apartheid i sydafrika etablerede landets nye parlament en sandheds- og forsoningskommission, hvor ofre for apartheid fik mulighed for at fortælle deres historier under offentlige høringer i kommissions komité for menneskerettighedskrænkelser. I løbet af kommissionens arbejde...

  14. Ultrafast Laser Switching of Dielectrics

    DEFF Research Database (Denmark)

    Haahr-Lillevang, Lasse

    2016-01-01

    Denne afhandling fokuserer på interaktionen mellem intense ultrakorte laserpulser med dielektriske materialer med store båndgab, specifikt safir, kvarts og vand. Eksperimentelt er den tidsopløste udvikling af materialet samtidigt med og efter denne interaktion blevet målt og fortolket på basis af...

  15. Revolution eller evolution?

    DEFF Research Database (Denmark)

    Kaarsted, Thomas

    2009-01-01

    Digital Natives, Google Generationen, Dot Net-generationen. Mens forskerne søger efter den rigtige term søger bibliotekerne at lægge strategier for fremtiden. Et bredt anlagt forskningsprojekt giver et bud på udviklingen og har en udløber til forskningsbibliotekerne. Kritikerne mener projektet...

  16. Patientkarakteristika og honoreringsmodeller for almen praksis

    DEFF Research Database (Denmark)

    Rose Olsen, Kim; Kristensen, Troels; Thomsen, Janus Laust

    2014-01-01

    ¬ordning, som bygger på en blanding af ”fee for service” og ”per capita”. Forfatterne diskuterer sammen¬hænge mellem helbred, socioøkonomi og afregningsmodeller. Meget taler for, at basishonoraret fremover bør differentieres efter patientens helbredstilstand og praksispopulationens socioøkonomiske...

  17. Mediebegivenheden Fukushima

    DEFF Research Database (Denmark)

    Sejrup, Jens

    2016-01-01

    Da Fukushima-ulykken udspillede sig i dagene efter den 11. marts 2011, forbløffede det medier i resten af verden, hvordan de japanske massemedier valgte at dække den meget alvorlige og eskalerende begivenhed. Mens vestlige nyhedsmedier efterspurgte større åbenhed og mere substans i de sparsomme...

  18. Protein til nykælvere

    DEFF Research Database (Denmark)

    Larsen, Mogens

    2013-01-01

    Ny forskning fra AU-Foulum viser, at det er muligt at øge mælkeydelsen ved at øge AAT forsyningen i de allerførste uger efter kælvning. Men de første tiltag i praksis tyder på, at flere forhold afgør udfaldet....

  19. Om de menneskeretlige problemer ved at indskrænke adgangen til familiesammenføring for personer med midlertidig beskyttelsesstatus

    DEFF Research Database (Denmark)

    Storgaard, Louise Halleskov

    2016-01-01

    Artiklen analyserer, hvorvidt den nyligt vedtagne stramning af udlændingeloven, hvorefter udlændinge, der er tildelt midlertidig beskyttelsesstatus i Danmark, først efter tre år kan ansøge om familiesammenføring her i landet, er i overensstemmelse med retten til respekt for familieliv og forbudde...

  20. Xiismen og dens kritikere

    DEFF Research Database (Denmark)

    Mulvad, Andreas Møller

    2016-01-01

    Kinas venstrefløj står i et klassisk dilemma i jagten på et alternativ til Xi Jinpings autoritære kapitalisme: Skal man fastholde de traditionelle bondefællesskaber eller søge inspiration i en urban arbejderklasse efter vestligt forbillede? To toneangivende intellektuelle, bondelederen Wen Tiejun...

  1. Immediat indsættelse af enkelttandsimplantater i privat praksis

    DEFF Research Database (Denmark)

    Hartlev, Jens; Kohberg, Peter; Ahlmann, Søren

    2015-01-01

    metode – I alt 55 patienter med 55 enkelttandsimplantater blev inkluderet i undersøgelsen. Behandlingen involverede tandekstraktion, implantatindsættelse, påsætning af et endeligt, individuelt abutment og en provisorisk krone I samme behandlingsseance. Den endelige krone blev efterfølgende påsat efter en...

  2. Strategier for integreret sundhedsfremme - et review

    DEFF Research Database (Denmark)

    Lau, Charlotte Bech; Holm, Jesper; Andersen, John

    over for ulighed i sundhed efter disse erfaringer og koncepter. Bogen omhandler derved, hvilke processer, tilgange og strategier der har betydning for, at kommunal sundhedsfremme i praksis kan være en reel fælles opgave mellem borgere, professionelle, kommunale og civile aktører. Vi har heri valgt...

  3. Tegn på lærerudvikling – Rapport 1. En evaluering af KLEO-projektets første runde 2018

    DEFF Research Database (Denmark)

    Lund, Lea

    2018-01-01

    -projektet, fra ja-nuar til april 2018 understøttet af de otte KLEO-konsulenter tilknyttet projektet. Fra efteråret 2018 skal disse erfaringer spredes til yderligere fire skoler: Grenaa gymnasium: HF, Randers HF & VUC: AVU, SOSU Herning: SOSU og Silkeborg Business College: HHX. På hver af disse skoler deltager...

  4. The product life cycle revisited

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    1995-01-01

    Efter et introduktionsafsnit følger afsnit II, hvor der gives en historisk analyse af Life Cycle Assessment (LCA) og Environmental Impact Assessment (EIA). I afsnit III munder analysen ud i en vurdering af ligheder og forskelle mellem LCA analyser og EIA analyser, og en diskussion følger af...

  5. Gødning er mere vigtig for grønkåls smag end frost

    DEFF Research Database (Denmark)

    Grønbæk, Marie

    2016-01-01

    Mange kender myten om, at grønkål smager bedre efter termometret har været nede i det blå felt. Ny forskning viser, at smagen ganske rigtigt ændrer sig – men mængden af gødning er faktisk mere afgørende for smagen....

  6. Magtens byrum - Taksim Pladsen i Istanbul

    DEFF Research Database (Denmark)

    Samson, Kristine

    2013-01-01

    Gensyn med Istanbul i dag efter Occupy Gezi i maj viser med al tydelig, at der var noget at protestere i mod. Protesten var rettet mod byudviklingens omdannelse af Taksim Pladsen og rydningen af Gezi Park. Som midlertidig og borgerdreven begivenhed må Occupy Gezi dog ikke kun ses som protest...

  7. Use of general practice before and after mild traumatic brain injury: a nationwide population-based cohort study in Denmark

    DEFF Research Database (Denmark)

    Galili, Stine Fjendbo; Bech, Bodil Hammer; Vestergaard, Claus Høstrup

    2017-01-01

    Milde hovedtraumer ses hyppigt i de danske akutafdelinger, og følgevirkningerne af milde hovedtraumer er stærkt omdiskuterede. Formålet med dette nationale studie var at beskrive brugen af almen praksis før og efter et mildt hovedtraume og bruge antallet af kontakter som en proxy variabel...

  8. USA under attack?!?

    DEFF Research Database (Denmark)

    Hansen, Tia

    2005-01-01

    Argumenterer for, at blitzerindringer for offentlige begivenheder bør forstås som en særlig variant af kollektiv hukommelse. Med udgangspunkt i spørgeskemadata indsamlet fra 129 danskere dagen efter angrebet på World Trade Center d. 11. september 2001 diskuteres dels det indtryk, denne begivenhed...

  9. Hjernevask og Radikalisering i Grimhøjmoskeen

    DEFF Research Database (Denmark)

    Suhr, Christian

    2015-01-01

    Onsdag mødtes Folketinget for at diskutere radikalisering og muligheden for at lukke moskeer, som forkynder anti-demokratiske holdninger. Flere politikere har udtalt, at når det kommer til islamisk ekstremisme, er det nytteløst at lede efter forklaringer. Ud fra min forskning og mit feltarbejde b...

  10. The Kiss of Grace

    DEFF Research Database (Denmark)

    Tillisch, Rose Marie

    2004-01-01

    Bernhard af Clairvaux (1090-1153) og Martin Luther (1483-1546) læste begge Gammel Testamente som én lang længsel efter Kristus. De havde dog hver deres favoritter indenfor det gammeltestamentlige korpus. For Bernhard var Højsangen en stadig inspirationskilde, mens Salmernes Bog var grundlag for L...

  11. Ludvig Holbergs Heltehistorier

    DEFF Research Database (Denmark)

    Schmidt, Kristoffer

    I 1739 udgav Ludvig Holberg værket Adskillige store Heltes og berømmelige Mænds, sær Orientalske og Indianske sammenlignede Historier og Bedrifter efter Plutarchi Maade (Heltehistorier). Bogen baserede sig på Plutarchs parallelbiografiske metode fra værket Vitae Parallelae. Det blev til i alt tolv...

  12. Den lille krig i fredstid. Danske militære erfaringer i Musa Qala i 2006

    DEFF Research Database (Denmark)

    Brink Rasmussen, Jakob

    2018-01-01

    Den 1. Lette Opklaringseskadron fra Bornholms forsvar af distriktscentret Musa Qala i den afghanske Helmand-provins i eftersommeren 2006 gennemanalyseres. Det sker med det formål at klarlægge, hvordan man udnyttede læring under forberedelsen til indsættelsen samt under og efter denne. Herunder da...

  13. Aktietilbagekøb og selvfinansierede aktiekøb

    DEFF Research Database (Denmark)

    Werlauff, Erik; Larsen, Luise Guldbæk; Larsen, Dorte Riskjær

    Efter selskabsreformen 2010 kan både aktie- og anpartsselskaber opkøbe egne aktier eller anparter ("kapitalandele") langt ud over den tidligere grænse på 10 pct. af selskabskapitalen (og transaktionen var tidligere helt forbudt for anpartsselskaber). Dette giver en lang række nye muligheder, men ...

  14. Pendlingens sociale geografi - mod en ny type pendlingsforståelse

    DEFF Research Database (Denmark)

    Olesen, Anne Vingaard; Kjems, Erik; Reinau, Kristian Hegner

    holdninger til pendling, hvilken korreleres til det billede, der tegnes geografisk. Data behandles i softwarepakken STATA 13 samt i QGIS. Resultater Spørgeskemadata fra 2,235 respondenter blev indsamlet af Gallup i efteråret 2015. Ud af disse opgav 1,508 respondenter adresser på henholdsvis hjem og...

  15. Sammenligning af laboratorieforsøg med kemiske, biologiske og termiske metoder til oprensning af residual fri fase under grundvandsspejlet i Kærgård Plantage

    DEFF Research Database (Denmark)

    Christophersen, Mette; Christensen, Jørgen Fjeldsø; Jørgensen, Torben H.

    , sulfonamider, barbiturater, anilin, cyanid og kviksølv, og det har resulteret i en meget kompleks forurening. Efter afgravning af 4000 tons meget forurenet jord ned til grundvandsspejlet i to af de seks gruber er næste skridt afprøvning af forskellige metoder til fjernelse af den kraftige grundvandsforurening...

  16. Japansk design

    DEFF Research Database (Denmark)

    Kural, René

    2005-01-01

    Artiklen udspringer af interviews med ti af Japans bedste møbeldesignere, grafikere, arkitekter og designfirmaer. Efter samtalerne var der tre træk ved japansk design, som trådte frem: god økonomi, fantasi og vovemod. Det bedste japanske design fusionerer vovemod med den unikke japanske kultur med...

  17. Kreative metoder i verbal supervision

    DEFF Research Database (Denmark)

    Jacobsen, Claus Haugaard

    2013-01-01

    , bevægelser i rummet, etc.) og 4) der primært kommunikeres via verbal-sproglige udvekslinger. Efter en diskussion af forholdet mellem kreativitet og kreative metoder, fokuseres der på relevansen af og måder til adgang til ubevidste manifestationer. Sproget non- og paraverbale betydning inddrages. Et centralt...

  18. Biochemical changes in blood caused by radioisotopes

    International Nuclear Information System (INIS)

    Zapol'skaya, N.A.; Fedorova, A.V.

    1975-01-01

    The changes were studied occurring in some biochemical indicators in blood at chronic peroral administration of strontium-90, cesium-137 and iodine-131 in amounts resulting in accumulation of commensurable doses in critical organs corresponding to each isotope

  19. Application of insulin RIA in determining deviations of glycide metabolism in women on steroid contraception

    International Nuclear Information System (INIS)

    Dvorak, V.; Kimlova, I.; Malkova, J.; Bartos, V.; Novakova, O.; Visek, V.

    1981-01-01

    The oral glucose tolerance test was performed, RIA was done, immunoreactive insulin was determined after peroral glucose load using the double antibody method, and routine clinical and laboratory examinations were carried out in 27 women on long-term peroral contraception and in 10 controls. In the women using contraceptives, glucose tolerance and insulin secretion disorders were relatively frequent. The incidence depended on the genetic burden; their dependence on smoking and the duration of contraception was not shown. In view of the fact that glycide metabolism disorders represent a significant risk factor for the development of ischemic heart disease, considerable caution is recommended in prescribing contraception in women with glycide metabolism irregularities or with diabetes in the family history. It is also recommended that during long-term contraception, the condition of the insular mechanism should be monitored. (author)

  20. Study on Continuing Vocational Training System in Denmark

    DEFF Research Database (Denmark)

    Hansen, Leif Emil; Thoregaard, Kamille

    2009-01-01

    4 partnerlande (Bulgarien, Danmark, Grækenland og Rumænien) har i et EU-finansieret projekt analyseret stærke og svage sider ved landenes respektive systemer og situationer vedrørende erhvervsrettet efter- og videreuddannelse (CVT) og livslang læring (LLL) - med henblik på at øge den fremtidige...

  1. Ecological and molecular responses to climatic stress in terrestrial springtails and oligochaete worms

    DEFF Research Database (Denmark)

    Waagner, Dorthe

    beskyttelsesmekanismer der er relaterede til tørke og rehydrering afhænger af tørkestress niveauet. Desuden er de molekylære ændringer efter kort- og langtids kuldepåvirkninger forskellige i F. candida, hvilket indikerer at de beskyttende mekanismer opnået ved henholdsvis kort- og langtids kuldeakklimering er...

  2. Investigation of phosphate compounds for use in medium temperature fuel cells and electrolyzers

    DEFF Research Database (Denmark)

    Risskov Sørensen, Daniel

    ledningsevne. Ved opvarmning til 200 °C udviste kompositterne ringe tegn på dehydrering, men ved opvarmning til 300 og 400 °C fandtes tydelige tegn på dehydrering af orthofosforsyre til pyrofosforsyre. Der blev påvist nogen grad af rehydrering efter afkøling til stuetemperatur. Resultaterne fra dette studie...

  3. Tendenser inden for den nyere fagsprogsforskning i Danmark

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Engberg, Jan

    1995-01-01

    I artiklen præsenteres hovedtendenserne i den fagsproglige forskning, der er foregået specielt med rod i handelshøjskolerne i Danmark i de seneste 25 år. Efter en indledning om fagsprogsbegreber og rammerne for fagsproglig forskning i Danmark præsenteres fagsproglige arbejder inden for områderne ...

  4. Architectural relations between Danish Cistercian churches and the Daughters of Esrum at Dargun, Eldena and Kolbacz

    DEFF Research Database (Denmark)

    Kristensen, Hans Krongaard

    2009-01-01

    En diskussion af det arkitektoniske forhold mellem de danske cistercienserkirker og Esrums "døtre" i det vendiske område: Dargun, Eldena og Kolbatcz. Det påvises, at sammenhængen ses i de jyske cistercienserkirke fra 1200-tallet, og at det vendiske byggeri væsnetligst finder sted efter sammenbrud...

  5. Fremtidens forbrugere vil have det hele

    DEFF Research Database (Denmark)

    Nielsen, Niels Asger

    2004-01-01

    Vi kan af gode grunde ikke vide, hvordan forbrugernes efterspørgsel efter svinekød vil udvikle sig i fremtiden, men vi kan med udgangspunkt i forskning give nogle kvalificerede og velunderbyggede ud på nogle overordnede udviklingstendenser - også kaldet megatrends - der vil præge markedet i det k...

  6. Retsplejelovens regulering af politiets adgang til teledata

    DEFF Research Database (Denmark)

    Lentz, Lene Wacher

    2017-01-01

    Politiet kan som led i en strafferetlig efterforskning få adgang til en række data om telekommunikation efter retsplejeloven, hvis regulering nu må revideres i lyset af ”Tele2-sagen”, hvor EU-domstolen fandt, at en generel logningspligt for teleudbyderne til at sikre teledata til brug for eventue...

  7. En bog om Michael Strunge

    DEFF Research Database (Denmark)

    Mai, Anne-Marie

    Antologi med bidrag om Michael Strunges forfatterskab. Bidrag af Anne-Marie Mai, Jørgen Aabenhus, Marianne Stidsen, Moritz Schramm, Tue Andersen Nexø, Lars Bukdahl, Jon Helt Haarder, Rune Kühl er optaget efter fagfællesbedømmelse. Antologien er redigeret af Anne-Marie Mai og Jørgen Aabenhus....

  8. Thirty-Day Mortality After Infection Among Persons With Severe Mental Illness

    DEFF Research Database (Denmark)

    Ribe, Anette Riisgaard; Vestergaard, Mogens; Katon, Wayne

    2015-01-01

    Personer med svære psykiatriske lidelser (skizofreni og bipolar lidelse) har sammenlignet med baggrundsbefolkningen en 15-20 år kortere forventet levetid, der hovedsageligt kan tilskrives naturlige dødfald. Det vides ikke, om dødsfald efter indlæggelse for infektion kan forklare en del af overdød...

  9. Freire and Danish social pedagogy

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2015-01-01

    Kapitlet viser Freires betydning for dansk socialpædagogik - både i snævrere forstand (anderledes pædagogik på døgninstitutioner og fællesskaber) og i bredere forstand (voksenoplysning). Her knyttes an til reformpædagogikken, som den udfoldedes efter 2. verdenskrig, og grundtankerne hos Freire un...

  10. Totalitarisme - videnskabeligt eller politisk begreb?

    DEFF Research Database (Denmark)

    Madsen, Peter

    2007-01-01

    Bogens abstract Er du ven eller fjende? Efter terrorangrebet i New York d. 11.9. blev det klart, ingen kan undslå sig det spørgsmål. Totalitarisme beskriver, hvordan et knivskarpt skel mellem civilisation og barbari, venskab og fjendskab går igen i de tre klassiske totalitarismer: fascisme, nazisme...

  11. Ny rapport advarer

    DEFF Research Database (Denmark)

    Jex, Catherine; Seidenkrantz, Marit-Solveig; Colgan, William

    2017-01-01

    Ifølge forskerne bag en ny mellemstatslig rapport vil den globale opvarmning få endnu flere og meget drastiske konsekvenser for det arktiske klima end hidtil antaget. Men klimaaftalen fra Paris kan afværge nogle af de største forandringer efter år 2050. Hvis den bliver implementeret øjeblikkeligt...

  12. Niels Hemmingsen

    DEFF Research Database (Denmark)

    Lausten, Martin Schwarz

    Præsentation af Niels Hemmingsen (1513-1600), hans biografi, forfatterskabet på ca. 100 skrifter og virke som professor i teologi ved Københavns universitet. Hans suspension i 1579 og forflyttelse til Roskilde skete efter pres fra kurfyrste August og hans hustru Anna,søster til Frederik d.2. Niel...

  13. Grasping the Existential Experience of Living with Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Larsen, Janni Lisander

    Dette projekt havde til formål at undersøge eksistentielle vilkår hos kvinder med sygdommen, systemisk lupus erythematosus, herunder hvordan disse vilkår blev erfaret gennem et langvarigt sygdomsforløb. Data blev konstrueret gennem 3 konsekutive, personlige interview sessions på dag 0, efter 6 og...

  14. Økonomisk bistand fra selskab til ejere og ledelse

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2009-01-01

    Dette bidrag til bogen gennemgår reglerne om "økonomisk bistand" fra et aktie- eller anpartsselskab til dets ejere, ledelse mv., dvs. reglerne om aktionærlån, koncernlån og selvfinansiering, således som disse er udformet efter selskabsreformen. Der erindres om tre vigtige egenskaber ved reformen:...

  15. Hjelmkamera som opmærksomhedsunderstøttende teknologi

    DEFF Research Database (Denmark)

    Bøhm, Mikkel; Hagedorn-Rasmussen, Peter; Nickelsen, Niels Christian

    2016-01-01

    Anvendelsen af en relativt simpel teknologi i form af et hjelmkamera kan understøtte og ændre opmærksomhed under og efter håndteringen af en operativ indsats. Hjelmkameraet er fastgjort til den overordnede leder fra brandvæsenet (indsatslederen). Gennem hjelmkameraet er det muligt at opnå indsigt...

  16. Revisionsklienters anvendelse af serviceleverandører

    DEFF Research Database (Denmark)

    Kjersgaard, Lisbeth; Kiertzner, Lars

    2011-01-01

    Artiklen præsenterer det overordnede indhold af den ajourførte ISA 402 om revisionsmæssige overvejelser ved revision af regnskaber for virk somheder, der anvender service-leverandører. Artiklen er opbygget efter de tre grundlæggende elementer i revisionsprocessen - planlægning, udførelse og rappo...

  17. Telemedicin 1

    DEFF Research Database (Denmark)

    Sørensen, John Aasted; Munck-Fairwood, Roger; Holst-Christensen, Bo

    2011-01-01

    Efter at have gennemført kurset, vil den studerende være i stand til at udføre følgende: - Redegøre for principper ved etablering af et telemedicinsk system, der sammenknytter en patient i privat hjem med en telemedicinsk hospitalsafdeling. Der tages udgangspunkt i de medicinske, organisatoriske,...

  18. Fra politiker til policy professionel

    DEFF Research Database (Denmark)

    Ørsten, Mark; Willig, Ida; Pedersen, Leif Hemming

    2017-01-01

    et studie af danske politikeres karriereveje efter, at de har forladt Folketinget. Studiet viser, at langt størstedelen af politikerne, der forlod Folketinget i perioden 1981 til 2015, fandt beskæftigelse uden for de nævnte jobtyper. Studiet identificerer dog også et begrænset marked for politisk...

  19. Antibiotic prescribing patterns in out-of-hours primary care

    DEFF Research Database (Denmark)

    Huibers, Linda; Moth, Grete; Christensen, Morten Bondo

    2014-01-01

    Denne artikel undersøger, hvor ofte der udskrives antibiotika efter henvendelse til lægevagten. Resultaterne viser, at omkring 15 % af all henvendelser fra borgere til lægevagten i den undersøgte periode endte med udskrivning af en recept på antibiotika: 26,1 % ved fremmøde, 10,7 % ved telefonkon...

  20. Beretning for undersøgelse af bopladsområde med værkstedsaktivitet fra yngre jernalder/vikingetid, neolitiske anlæg fortrinsvis fra MN A III og en grav fra MN B II. Kalmergården (KU) 2000

    DEFF Research Database (Denmark)

    Bican, Josefine Franck

    2001-01-01

    anlæggelse er omtalt nedenfor i en separat beretning ved Lone Gebauer Thomsen (se bilag 2). Yngre jernalder/vikingetid er den periode, der var bedst repræsenteret på pladsen. Her var spor efter en markeds-/produktionsplads, der er registreret vha. 3735 detektorfund, hvor især sølvskatten (KU 2337) skal...

  1. Field Evaluation of a Single-Word Pronunciation Training System

    DEFF Research Database (Denmark)

    Bernsen, Niels Ole; Hansen, Thomas; Kiilerich, Svend

    Efter udviklingen af programmet den Digitale Udtaletræner (DUT) beregnet på indlæring af dansk enkeltordsudtale for immigranter, er applikationen blevet aftestet på en række sprogskoler og institutioner i Danmark. Indeværende artikel analyserer og søger at belyse de relevante data der er blevet g...

  2. Projekt Skejby - Verden sundeste Erhvervsområde

    DEFF Research Database (Denmark)

    Christensen, Marie Ernst; Hansen, Peter Keller

    2013-01-01

    Formålet med evalueringen er, at undersøge hvorledes deltagerne har oplevet deltagelsen i projektet/tilbuddene med henblik på optimering af efterårets udbud, samt at undersøge de studerendes udbytte ved deltagelse i projektet. Det vil sige hvorvidt de studerende kan omsætte teori til praksis, dyg...

  3. Performance management i en krisetid

    DEFF Research Database (Denmark)

    Elmholdt, Claus Westergård; Hoffmann Birk, Rasmus; Børgesen, Kenneth

    2015-01-01

    Denne artikel undersøger, om ’performance management’ – eller på dansk præstationsledelse – er et effektivt svar på de udfordringer, som organisationer står overfor i krisetider. I tiden efter finanskrisen i september 2008 er det blevet endnu mere relevant for ledere at kunne navigere i en...

  4. Medicoteknik 4

    DEFF Research Database (Denmark)

    Sørensen, John Aasted; Sørensen, John Kryger; Jeppesen, Lau

    2011-01-01

    Efter at have gennemført kurset vil den studerende være i stand til at - forstå principperne for måling af human fysiologiske signaler med elektroder for et udvalg af signaltyper, - anvende et praktisk elektrodebaseret målesystem til klinisk måling, - foretage en vurdering af fejlkilder ved elekt...

  5. CM(dat) Seminarer 2003

    DEFF Research Database (Denmark)

    Denne publikation indeholder en samling af artikler som skrevet af Cand. Merc.(dat.) studerende på deres 3. semester i forbindelse med linieseminar i datalogi i efteråret 2003. Opgaver som de studerende har løst har været at skrive en teoretisk oversigtsartikel inden for et selvvalgt emne. Formål...

  6. Challenging Climate Change

    DEFF Research Database (Denmark)

    Hundebøl, Nils Randlev

    2014-01-01

    Ideen om menneskeskabte forandringer af jordens klima udviklede sig i løbet af det 20. århundrede fra en ufattelig og obskur ide til at være allemandsviden. I årtierne umiddelbart efter anden verdenskrig viser konturerne sig af den forskning, der i dag bærer ideerne om klimaforandringer. Fra 1970...

  7. Kommunernes arbejde med sundhedsfremme og bæredygtig udvikling i relation til folkeskolen

    DEFF Research Database (Denmark)

    Nordin, Lone Lindegard; Madsen, Katrine Dahl; Andersen, Tanja Thinggaard

    Denne rapport præsenterer en landsdækkende undersøgelse af kommunernes arbejde med sundhedsfremme og bæredygtig udvikling i relation til folkeskolen. Undersøgelsen er udført i efteråret 2013 i Forskningscenter for sundhedsfremmende bæredygtig skoleudvikling ved DPU, Aarhus Universitet. Formålet m...

  8. Logning af teledata i lyset af Tele2-dommen

    DEFF Research Database (Denmark)

    Lentz, Lene Wacher

    2017-01-01

    De danske teleudbydere har siden 2007 været underlagt en pligt efter logningsbekendtgørelsen til at registrere data om al telekommunikation for at sikre at data er tilgængelige ved en eventuel senere efterforskning. Logningspligten må nu revideres og i vidt omfang afvikles som følge af EU-domstol...

  9. Resten i Vesten

    DEFF Research Database (Denmark)

    Moberg, Bergur Rønne

    på formelle elementer ved ikke at privilegere det radikalt nye efter et vestligt-avantgardistisk mønster. Forskellen bliver tydelig i kraft af den ballast af geografi, kultur, historie og politik som de færøske forfattere tænker med, og som afføder en anden udviklings- og originalitetsopfattelse end...

  10. A Study of Graphene

    DEFF Research Database (Denmark)

    Jensen, Bjarke Bror Egede

    Materialevidenskaben gennemgår en mindre revolution i disse år, efter 2-dimensionelle (2D) materialer gjorde sit indtog i 2004. Sammenlignet med deres 3-dimensionelle modstykker, udviser denne type materialer en række særlige egenskaber som gør at at de kan komme i betragtning som aktive komponen...

  11. Tuberkulose forårsaget af Mycobacterium africanum

    DEFF Research Database (Denmark)

    Bek, Dorte; Kjeldsen, Marianne Kirstine; Hansen, Nikolaj Friis

    2010-01-01

    Tuberkulose (TB) forårsages af patogene arter fra Mycobacterium tuberculosis komplekset (MTBC) og har en incidens på cirka 7/100.000 i Danmark. På mistanke om TB hos en akut indlagt 40 årig afrikansk mand initieredes anti-TB behandling. Efter 13 timers indlæggelse afgik patienten ved døden. Fra...

  12. Resource recovery from waste incineration residues

    DEFF Research Database (Denmark)

    Allegrini, Elisa

    Affaldsforbrænding er i mange lande en vigtig teknologi til behandling og energiudnyttelse af affald. Udover energi resulterer forbrænding også i produktion af asker. Størstedelen af askerne udgøres af slagge, som efter behandling har gode tekniske egenskaber og kan anvendes til bygge- og anlægsf...

  13. Antikkens veje til renæssancens Danmark

    DEFF Research Database (Denmark)

    , og vi møder foruden Petrarca blandt andre også den store humanist Erasmus af Rotterdam, den danske professor Erasmus Lætus, der skrev digte på latin, og kong Christian IV, der udsmykkede Frederiksborg Slot efter antikke idealer. Alle trak de på antikken som forbillede for at kunne opfylde deres egne...

  14. Systemic Struggle between North American Indians and New Age

    DEFF Research Database (Denmark)

    Geertz, Armin W.

    2008-01-01

    Bidraget undersøger den såkaldte hvalfangst-kontrovers, som makah-indianerne i delstaten Washington USA blev udsat for efter at den internationale hvalkommission i 1997 havde givet tilladelse til makah-indianerne til at fange 5 californiske gråhvaler pr. år i fire år. Det var mange miljøorganisat...

  15. Arkitektur, materialer, teknologi

    DEFF Research Database (Denmark)

    2004-01-01

    En redigeret samling af bidrag til en "tænkt" lærebog om arkitektur, materialer og teknologi, udført af studerende i forbindelse med kursus 0.021. Bygning, produkt og projekt, september 2004. Består af ca. 100 artikler, inddelt efter materialer som tegl, træ, sten, beton, metal, glas, plast...

  16. Improving the quality of nursing documentation by using the Danish Electronic Health Record

    DEFF Research Database (Denmark)

    Adellund, Kamila; Lindholm, Annette

     Baggrund: Efter indførelsen af EPJ på Obstetrisk/Gynækologisk afdeling opstod der behov for viderearbejde med dokumentationen af sygeplejen. Det er ikke kun spørgsmål om, hvor skriver vi hvad, men også hvad skal sygeplejedokumentationen indeholde for at den lever op til kravene opstillet af Sund...

  17. Ledelse af forandringer i folkeskolen

    DEFF Research Database (Denmark)

    Kjer, Mikkel; Rosdahl, Anders

    2016-01-01

    Dette notat bygger på kvalitative interview på seks folkeskoler i efteråret 2015. Skolerne ligger i forskellige egne af landet og i landområder, mindre og store byer. Skolerne er af forskellig størrelse, og deres elevgrundlag, dvs. forældrenes sociale baggrund, varierer også. Notatet bygger primæ...

  18. Den sociale stofmisbrugsbehandling. Del 1

    DEFF Research Database (Denmark)

    Heltberg, Therese

    Denne rapport er den første delrapport i en undersøgelse af den sociale stofmisbrugsbehandling i Danmark, som SFI har gennemført for Servicestyrelsen i perioden december 2007 til maj 2009. Undersøgelsen omhandler den sociale stofmisbrugsbehandling efter § 101 i Serviceloven, mens undersøgelsen i ...

  19. Kina

    DEFF Research Database (Denmark)

    Nørup Sørensen, Camilla Tenna

    2017-01-01

    udvikling er kun blevet yderligere fremskyndet efter, at Donald Trump har indtaget Det Hvide Hus og med „America First” har varslet et mere isolationistisk USA. Det åbner nye muligheder og giver et større internationalt handlerum for Kina. Kapitlet har til formål at give baggrunden og konteksten for Kinas...

  20. 30 år med Musikterapi. Oplevelser, Erfaringer, Visioner

    DEFF Research Database (Denmark)

    2012-01-01

    I anledning af musikterapiuddannelsens 30 års jubilæum har vi opsøgt og interviewet relevante samarbejdspartnere for at få et indblik i, hvordan de opfatter musikterapien. Efter 30 år, hvor vi konstant har arbejdet på at forbedre musikterapiuddannelsen, synes vi nemlig, at det er spændende at und...

  1. Når logopæden hører stemmer

    DEFF Research Database (Denmark)

    Iwarsson, Jenny

    2011-01-01

    Da jeg for leden henvendte mig til et bilværksted på Amager og gav en kort beskrivelse af den foruroligende lyd jeg registreret i min bil, svarede bilmekanikeren hurtigt, at det med stor sandsynlighed var tale om et kuglelager i venstre forhjul der skulle skiftes. Efter en kort prøvetur hvor meka...

  2. Coupling of Active Components to Synthetic Polymers

    DEFF Research Database (Denmark)

    Overgaard, Anne Kathrine Kattenhøj

    Arbejdet har fokuseret på fremstilling af kunstig ekstracellulær matrix (ECM) til fremme af den naturlige biologiske helingsproces ved vævsgendannelse efter store vævsskader. Særlig opmærksomhed har været på kemisk kobling af dermatan sulfat (DS), en naturlig glyco-saminoglycan (GAG), med en biok...

  3. Florence Nightingale som symbolsk overgangsfigur i lærebøger for sygeplejersker - et lille stykke sygeplejehistorie

    DEFF Research Database (Denmark)

    Jørgensen, Emmy Brandt

    2009-01-01

    Artiklen er et lille indlæg om, hvordan man har anvendt Florence Nightingale i danske lærebøger for sygeplejersker som en legitimeringsfigur i forbindelse med forandringer inden for det danske hospitalsvæsen. Perioden, der behandles, er tiden før og efter skiftet til den kliniske medicin i Danmark...

  4. Finanskrisen - er den markedsorienterede regulering skurken?

    DEFF Research Database (Denmark)

    Grosen, Anders

    2009-01-01

    markedsorienterede opgørelse tilsyneladende skyld i bankernes dårlige resultater. I hvert fald er standardsætteren inden for international regnskabsregulering, IASB, i efteråret 2008 på rekordtid kommet de betrængte virksomheder - herunder bankerne - til undsætning med en regnskabsmæssig hjælpepakke som supplement...

  5. Dansk oversættelse af MiDAS, et redskab til assessment af musikterapi for personer med demens

    DEFF Research Database (Denmark)

    Ridder, Hanne Mette Ochsner; Lykkegaard, Chris; McDermott, Orii

    2018-01-01

    Music in Dementia Assessment Scales, MiDAS, er udviklet til at vurdere ændringer i trivsel hos borgere med demens som har deltaget i musikterapi. Målingen udføres af 1) personale før og efter musikterapien for at vurdere om der er en indflydelse i hverdagssituationer efterfølgende, eller af 2......) musikterapeuten umiddelbart efter sessionen for at vurdere forandringer i selve sessionen. Der har været stor interesse for at anvende MiDAS i flere Europæiske lande, herunder Danmark. Derfor undersøgte udviklerne af MiDAS hvilke procedurer der anvendes til oversættelse og kulturel tilpasning af...... assessmentredskaber, og anbefalede på den baggrund en ti-trins procedure. Vi anvendte denne procedure til oversættelsen af MiDAS og således udviklingen af den danske MiDAS-DK. Den danske version af MiDAS er afprøvet af mere end 20 fagpersoner på baggrund af 296 udfyldte MiDAS-skemaer. Målet med artiklen er...

  6. Predicting effects and risk of relapse into depression

    DEFF Research Database (Denmark)

    Gbyl, Krzysztof; Rosenberg, Raben; Larsson, Henrik Bo Wiberg

    Formål: Vi ønsker at undersøge hjernen hos patienter med svær depression før og efter elektrokonvulsiv terapi (ECT), samt ved en kontrol efter 6 måneder med det formål at: 1. undersøge hjernevævet så en evt. skadelig effekt af ECT-behandling kan udelukkes 2. belyse mekanismerne bag ECT for at finde...... prædiktorer for gunstige resultater, tidligt tilbagefald og for bivirkninger 3. undersøge omfanget af og baggrunden for påvirkningen af hukommelsesfunktionen Metode: I studiet planlægger vi at undersøge 60 patienter henvist til ECT på Psykiatrisk Center Glostrup, Amager og København pga. svær depression....... Desuden vha. den mest moderne MR-teknik at belyse om ECT kan skade hjernevævet. De nævnte prædiktorer vil muliggøre at behandlingen af de sværeste depressioner vil kunne forbedres og individualiseres i langt højere end i dag, hvorved sygdomsprognosen kan forbedres betydeligt. Vi forventer yderligere...

  7. Invariants

    Indian Academy of Sciences (India)

    Example 1 (Word Problem): This is taken from Em- peror's New Mind ... is as follows. We are given a set of equalities of words .... pictures without proper definitions, and without being ... a polynomial, or in other words it could be a collection of.

  8. Method for prophylaxis of postradiation complications in oncological diseases

    International Nuclear Information System (INIS)

    Ghicavii, Victor; Gavriluta Vadim

    2012-01-01

    The invention relates to medicine, namely to radiotherapeutic treatment in oncology. Summary of invention consists in the fact that once a day, immediately after meals, during 15 days from the start of the course of radiotherapy, is intramuscularly administered 5 ml of 5% solution of ascorbic acid and perorally one capsule (33000 IU) of retinol, one capsule (0.2 g) of tocopherol and one tablet (0.2 g) of methyluracil. At the same time, starting 2...3 days prior to the start of the course of radiotherapy, as well as along its entire length, is perorally administered a mixture of grape seed oil and pumpkin seed oil, in a ratio of 1:1, one tablespoon (15 ml) twice a day, concomitantly is applied the mixture of oils on the skin in the region subjected to irradiation. The result consists in diminishing the local and general postradiation complications in oncologic patients.

  9. Røntgenstereometrisk analyse efter total knaealloplastik

    DEFF Research Database (Denmark)

    Therbo, Matthias; Lund, Bjarne

    2009-01-01

    In 1974 Selvik introduced marker-based roentgenographic stereogrammetric analysis (RSA), a highly accurate technique for measuring three-dimensional migration of orthopaedic implants. Novel, promising, user-friendly, fast and in some cases noninvasive RSA techniques (model-based RSA, image......-based RSA and fluoroscopic RSA) have been developed, and some have recently been validated. However, the most reliable RSA technique so far is marker-based RSA. A standardization protocol for RSA studies is required. In the future, implant-testing using RSA should be used routinely in selected Danish...

  10. Patienttilfredshed efter bariatrisk og postbariatrisk kirurgi

    DEFF Research Database (Denmark)

    Poulsen, Lotte; Roessler, Kirsten Kaya; Rose, Michael

    2015-01-01

    Surgical treatment of obesity has led to a large group of patients with massive weight loss. The massive weight loss results in excessive skin, which leads to pain, skin problems, cosmetic discomfort and psychosocial issues. The impact on quality of life of bariatric and body contouring surgery can...

  11. Plastkirurgi efter stort vægttab

    DEFF Research Database (Denmark)

    Winge, Rikke; Henriksen, Trine Foged; Printzlau, Andreas

    2014-01-01

    Post bariatric body contouring in Denmark is currently a field under development. The scope of this article is to give an overview of existing plastic surgery techniques being used to treat patients with massive weight loss, as well as the current indications for patient referral. Furthermore, we...

  12. Plastikkirurgi efter stort vægttab

    DEFF Research Database (Denmark)

    Winge, Rikke; Henriksen, Trine Foged; Printzlau, Andreas

    2014-01-01

    Post bariatric body contouring in Denmark is currently a field under development. The scope of this article is to give an overview of existing plastic surgery techniques being used to treat patients with massive weight loss, as well as the current indications for patient referral. Furthermore, we...

  13. Hypotyroidisme efter operation for struma ovarii

    DEFF Research Database (Denmark)

    Zikkenheimer, Marjoes; Hertz, Jens

    2013-01-01

    . In approximately 5% of the cases patients may show symptoms of hyperthyroidism or thyrotoxicosis. Treatment comprises surgical removal. In the presented case the patient developed biochemical signs of hypothyroidism after the operation. It is recommended that thyroid function should be controlled after treatment....

  14. Osteoporosebehandling kan pauseres efter individuel vurdering

    DEFF Research Database (Denmark)

    Eiken, Pia Agnete; Abrahamsen, Bo

    2017-01-01

    In most patients, treatment of osteoporosis is a long-term challenge. Because alendronate and zoledronic acid accumulate in bone with some persistent antifracture efficacy after therapy, it is reasonable to consider a "drug holiday" for low-risk patients. It is recommended that the duration...

  15. Maksilrekonstruktion med stilket temporalislap efter maksillektomi

    DEFF Research Database (Denmark)

    Lambertsen, Karin; Bundgaard, Troels

    2009-01-01

    INTRODUCTION: Removal of the maxilla requires adequate restoration of the maxillary structure to replace form and functions, especially vocal and eating functions. A host of reconstructive options are available to restore the maxilla, most of which include free-flap reconstruction. The aim of thi...... developed oro-nasal/antral fistula, witch were later closed using local flaps. CONCLUSION: The follow-up study of the 27 patients showed a most satisfactory result evaluated objectively as well as subjectively using the EORTC questionnaire. Udgivelsesdato: 2009-Aug-17...

  16. Ambulant ST-segmentmonitorering efter akut myokardieinfarkt

    DEFF Research Database (Denmark)

    Mickley, H; Junker, A; Friis, E V

    1994-01-01

    Over the last decade the concept of silent myocardial ischaemia has received considerable attention. Without doubt, the increased use of ambulatory ST-segment monitoring is the most important reason for the growing interest in this field. The prevalence of ambulatory ischaemia after myocardial...... with previous myocardial infarction, but there is considerable disagreement about how this is expressed in terms of cardiac events. Patient selection, small patient numbers, and different timing of ambulatory monitoring are proposed as important reasons for the inconsistent findings. The precise role...

  17. Ventrikelperforation efter indtagelse af flydende kvaelstof

    DEFF Research Database (Denmark)

    Knudsen, Anders Riegels; Nielsen, Casper; Christensen, Peter

    2009-01-01

    A 28-year-old male was admitted to hospital with severe abdominal distension and subcutaneous emphysema after ingesting 15 ml liquid nitrogen to produce an impressive burp. A rupture of the stomach at the lesser curvature was sutured by laparotomy. Peroperative gastroscopy showed no signs of cold......-induced lesions. Liquid nitrogen boils at -196 degrees C. When heated to body temperature, it instantly expands 700 times, in this case predictably leading to gastric rupture. Therefore, any oral intake of even small amounts of liquid nitrogen should be avoided. Udgivelsesdato: 2009-Feb-9...

  18. Rekonvalescens og funktionstab efter intensiv terapi

    DEFF Research Database (Denmark)

    Poulsen, Jesper B; Møller, Kirsten; Perner, Anders

    2009-01-01

    More patients survive critical illness, which emphasises the need to assess outcome measures other than mortality. A prolonged decline in physical function is frequently observed after discharge in the critically ill. Neuromuscular dysfunction and muscle atrophy incurred during intensive care may...

  19. Kruralt kompartmentsyndrom efter kirurgi i stensnitleje

    DEFF Research Database (Denmark)

    Krarup, Peter-Martin; Rawashdeh, Yazan F

    2008-01-01

    Lower limb compartment syndrome after prolonged surgery in the lithotomy position is a rare but devastating complication which is termed well leg compartment syndrome (WLCS). The pathogenesis comprises increase in intracompartmental pressure and hypoperfusion, resulting in ischemia and necrosis. ....... By reviewing the PubMed database we found 38 case reports with a total of 58 patients who developed WLCS. Every surgeon should know WLCS as early diagnosis and treatment is essential to avoid severe permanent disability. Udgivelsesdato: 2008-Apr-28...

  20. Sen udvikling af carotisdissektion efter trafikuheld

    DEFF Research Database (Denmark)

    Hjort, Mathias; Ljungberg, Merete; Jakobsen, Linda

    2011-01-01

    This case study discusses the clinical manifestations of carotid dissection in a 58-year-old male admitted with minor injuries after a traffic accident. Within 24 hours the patient developed Horner syndrome, hoarseness and possible facial nerve palsy. A CT-angiogram showed dissection of the left...

  1. Hospitalsbehandling efter hjertestop uden for hospital

    DEFF Research Database (Denmark)

    Grand, Johannes; Hassager, Christian; Kjærgaard, Jesper

    2017-01-01

    Survival from out-of-hospital cardiac arrest in Denmark has increased significantly since 2001, and important improvements have been made in the post-resuscitation care. The aim of this article is to summarize the most recent international guidelines for post-resuscitation care in a Danish perspe...... perspective. The main aspects concern securing haemodynamic and respiratory functions and performing urgent coronary catheterization and targeted temperature management in selected patients. In prognostication a multi-modal approach should be applied....

  2. Patientdeltagelse under rehabilitering efter en rygmarvsskade

    DEFF Research Database (Denmark)

    Angel, Sanne

    2010-01-01

    insight into patient participation. The ability and need for participation changed through the six-phased process of regaining meaning after a spinal cord injury; no will to participate, developing/generating strength to participate, need for participation and will to participate in decision......This paper investigates the patient's ability and need for participation during rehabilitation. The application of Ricoeur's phenomenological-hermeneutic interpretation theory with a narrative approach revealed that the rehabilitation process of 12 persons was successful in providing specific......-making. Concurrently, the existential meaning of patient participation was uncovered. The conclusion was that the professional's hard work of stimulating the patient to participate and then permit the patient to take part was decisive in relation to the patient's existence and recovery....

  3. Incidensen af tertiaer hyperparatyroidisme efter nyretransplantation

    DEFF Research Database (Denmark)

    Nielsen, Tomas; Brixen, Kim T; Jespersen, Bente

    2008-01-01

    INTRODUCTION: Tertiary hyperparathyroidism (3 degrees HPT) is a condition characterized by autonomous secretion of parathyroid hormone (PTH) which develops as a consequence of secondary hyperparathyroidism in patients with chronic renal failure. Severe cases of 3 degrees HPT are treated with para......INTRODUCTION: Tertiary hyperparathyroidism (3 degrees HPT) is a condition characterized by autonomous secretion of parathyroid hormone (PTH) which develops as a consequence of secondary hyperparathyroidism in patients with chronic renal failure. Severe cases of 3 degrees HPT are treated...... consecutive patients who underwent Tx at Odense University Hospital from 1/1/2000 to 12/31/2004. We defined 3 degrees HPT as at least one elevated measurement of P-PTH concurrent with elevated S-Ca2+. Elevated S-Ca2+ was defined as at least 5 consecutive, elevated measurements from 14 days to six months after...

  4. Bilateral akillesseneruptur efter behandling med ciprofloxacin

    DEFF Research Database (Denmark)

    Attarzadeh, Amir Pasha; Ryge, Camilla

    2013-01-01

    We report a case of spontaneous non-traumatic bilateral rupture of the Achilles tendons following ciprofloxacin treatment. A 54-year-old man presented with spontaneous Achilles tendon rupture on the left side, tendinitis and partial tear on the right side following few days of treatment with cipr......We report a case of spontaneous non-traumatic bilateral rupture of the Achilles tendons following ciprofloxacin treatment. A 54-year-old man presented with spontaneous Achilles tendon rupture on the left side, tendinitis and partial tear on the right side following few days of treatment...... with ciprofloxacin 500 mg twice daily and long-term treatment with prednisolon 10 mg once daily. This rare side effect caused by concurrent treatment with steroids and ciprofloxacin should be kept in mind. Any signs of tendinitis following this treatment should arouse the physicians' suspicion towards ciprofloxacin....

  5. Pseudomonas-follikulitis efter badning i spabad

    DEFF Research Database (Denmark)

    Uldall Pallesen, Kristine Appel; Andersen, Klaus Ejner; Mørtz, Charlotte Gotthard

    2012-01-01

    . We describe a 23-year-old healthy woman who developed a pustular rash and general malaise after using a spa bath contaminated with Pseudomonas aeruginosa. Bacterial culture from a pustule confirmed Pseudomonas folliculitis and the patient was treated with ciprofloxacin with rapid good effect....

  6. Osteoporosebehandling kan pauseres efter individuel vurdering

    DEFF Research Database (Denmark)

    Eiken, Pia A; Abrahamsen, Bo

    2017-01-01

    In most patients, treatment of osteoporosis is a long-term challenge. Because alendronate and zoledronic acid accumulate in bone with some persistent antifracture efficacy after therapy, it is reasonable to consider a "drug holiday" for low-risk patients. It is recommended that the duration...... and length of drug holiday should be individualized for each patient. For all other bisphosphonates data are limited. For other antiresorptive and anabolic agents "drug holiday" is not recommended....

  7. Resultater efter primaer stapedotomi ved otosklerose

    DEFF Research Database (Denmark)

    Wanscher, Jens; Grøntved, Aksel; Faber, Christian

    2009-01-01

    performed using small-fenester-technique in the period 1996-2005. Five experienced ear surgeons performed the operations. The surgeons were still in the learning phase with regard to otosclerosis surgery. RESULTS: A significant improvement was found regarding the air-conduction pure tone average (PTA) (52.......8 dB to 31.4 dB), the bone conduction PTA (25.2 dB to 23,1 dB), air-bone gap (27.6 dB to 8.3 dB), and the speech reception threshold (44.8 dB to 22.5 dB). One operation (0.6%) resulted in severe sensory-neural hearing loss, while other types of complications were seen after 7,2% of the operations...

  8. Administrative organisationsforandringer i kommunerne efter krisen

    DEFF Research Database (Denmark)

    Ghin, Eva Camilla Moll

    2017-01-01

    I denne artikel undersøges det ved hjælp af et sammenlignende casestudie af fem danske kommuner, hvordan krisen og den strammere statslige styring af kommunernes økonomi har bidraget til administrative organisationsforandringer i kommunerne. Der argumenteres for, at krisen og sanktionslovgivninge...

  9. Jernmangel og graviditet efter gastrisk bypassoperation

    DEFF Research Database (Denmark)

    Johannsen, Eva Christina; Milman, N; Wielandt, Hanne

    2014-01-01

    of the foetus. The article concerns the need for managing the malabsorption syndrome, iron deficiency in particular, both in antenatal care, during pregnancy, delivery and in the lactation period. We suggest frequent follow-up in these patients and intravenous iron therapy, when oral iron treatment...

  10. SNS vil høre om det supplerende materiale giver anledning til/ændrer på konklusionen de tidligere fremsendte risikovurderinger. Zea Majs NK603xMON810. Supplerende materiale til sagen. Modtaget 07-02-2005, deadline 25-02-2005, svar 23-02-2005

    DEFF Research Database (Denmark)

    Strandberg, Morten Tune

    2005-01-01

    Brev: Det tilsendte materiale giver ikke anledning til ændringer på konklusionen i tidligere risikovurderinger af MON810xNK603-majs til anden brug end dyrkning. Danmarks Miljøundersøgelser forventer således efter gennemgang af det supplerende materiale til sagen MON810xNK603 fortsat ingen væsentl...

  11. DanskOrdbogen

    DEFF Research Database (Denmark)

    Bergenholtz, Henning; Vrang, Vibeke; Almind, Richard

    DanskOrdbogen er en helt nyudviklet ordbog for alle, som vil skrive på dansk. Med 105.000 opslagsord og 1175 sider mættet med informationer er det også Danmarks største ordbog. Ordbogen er udviklet efter nye principper, som gør den mere brugervenlig end traditionelle ordbøger. Bl.a. har DanskOrdb...

  12. Self-Determination of Colonial Peoples

    DEFF Research Database (Denmark)

    Rytter, Jens Elo

    2008-01-01

    Efter at have været en dansk koloni i århundreder blev Grønland i 1953 en integreret del af Det Danske Rigsfællesskab. Med Resolution 849 fra 1954 godkendte FNs Generalforsamling denne ændrede status som det grønlandske folks udøvelse af sin selvbestemmelsesret. Efterfølgende har visse folkeretsj...

  13. Iran : Præstestyret - under udvikling eller afvikling

    DEFF Research Database (Denmark)

    Rahigh-Aghsan, Ali

    2010-01-01

    Man hører ikke længere om gadeprotester i Teheran. Efter de voldsomme kampe i Teheran først på året, er det tilsyneladende lykkedes den Islamiske Republik at tvinge oppositionen til tavshed. Ifølge lederen af 'den grønne bevægelse' og tidligere præsidentkandidat, Mousavi, er det islamiske regimes...

  14. Spilleregler i musikterapi med børn

    DEFF Research Database (Denmark)

    Holck, Ulla

    2005-01-01

    Artiklen gennemgår udvalgte eksempler på anvendelse af spilleregler i musikterapi med børneklientgrupper. Efter en kort introduktion af Priestleys syn på analytisk musikterapi med børn, præsenteres læseren således for en række caseeksempler fra faglitteraturen, der giver indblik i udformning og a...

  15. Forestillinger om lykke

    DEFF Research Database (Denmark)

    Storm, Ida Marie; From, Ditte-Marie

    2016-01-01

    Artiklen bygger på en specialeafhandling, der har undersøgt mødres forventninger om et lykkeligt moderskab. Mødre i Danmark bliver screenet for depression to måneder efter fødslen og kan ved mistrivsel og lav score blive tilbudt deltagelse i kommunale støttegrupper. Artiklen baserer sig på kvalit...

  16. Snyd er ikke bare snyd

    DEFF Research Database (Denmark)

    Bay, Gina

    2008-01-01

    I efteråret 2008 lanceres hjemmesiden http://www.stopplagiat.nu/ , der skal hjælpe studerende til at undgå at plagiere. Her kan studerende bl.a. teste, om de kender reglerne for korrekt kildehåndtering godt nok. Og hvis ikke, kan de få helt konkrete redskaber til, hvordan de laver præcise kildehe...

  17. Entrepreneurial Barriers to Strategy

    DEFF Research Database (Denmark)

    Elkjær, Jørgen Ravn

    2013-01-01

    En begrænsende faktor for strategisk ledelse er ofte iværksætterens uddannelse og erfaring, som efter en del forskningsbidrag synes at både fremme og hæmme bestemte strategie. Desuden kan der i hierarkier være en tendens til at opretholde de strategier, som blev dannet ved stiftelsen. Organisator...

  18. 10 + 10 + 10 = 24?

    DEFF Research Database (Denmark)

    Andersen, Johannes

    2014-01-01

    efter en 10+10+10 timers model. Ifølge lektor og samfundsforsker Johannes Andersen ved Institut for statskundskab på Aalborg Universitet, er antallet af stress ramte danskere steget fra 5 procent i 1989 til mere end 12 procent i 2010. Således tyder noget på, at danskerne ikke får den fornødne hvile....

  19. Miljøundersøgelser ved Maarmorilik 1999-2000

    DEFF Research Database (Denmark)

    Møller, P.; Asmund, G.; Johansen, P.

    I rapporten dokumenteres og vurderes forureningstilstanden ved den nedlagte blyzinkmine i Maarmorilik på baggrund af prøveindsamling i området i 1999 og 2000. Undersøgelserne viser, at der stadig frigives bly og zink fra kilder i området, men at miljøpåvirkningen efter minens lukning er betydeligt...

  20. Strategisk miljøvurdering af kommuneplaner III

    DEFF Research Database (Denmark)

    Hvidtfeldt, Henrik; Kørnøv, Lone

    første, hvordan samspillet og arbejdsdelingen mellem kommuneplanlægning, miljøvurdering og Agenda 21 skal være. For det andet, på hvilket indholdsmæssigt grundlag og efter hvilke metoder miljøvurderingen skal udføres. For det tredje, hvornår miljøvurderingen skal foretages, dvs. hvordan processen skal...

  1. Indkøbspraksisser I et SCM-perspektiv

    DEFF Research Database (Denmark)

    Helbo, Martin; Jakobsen, Jesper; Gammelgaard, Britta

    2004-01-01

    Dette working paper er en samling af case beskrivelser angående indkøbspraksisser i Danmark.Case-dataene er indsamlede i efteråret 2003 og foråret 2004. Alle beskrivelser er validerede af dedeltagende virksomheder. I den oprindelige undersøgelse var 10 virksomheder repræsenterede,men én af case-v...

  2. Økologisk restaurering af Øle Å med afsæt i forskningsmål og effektmålinger

    DEFF Research Database (Denmark)

    Båstrup-Spohr, Lars; Sand-Jensen, Kaj; Morsing, Jonas

    2015-01-01

    Traditionel økologisk restaurering bæres sjældent frem af videnskabelige hypoteser og solide målinger før og efter restaureringen. Derfor mangler solide data og videnskabelig evidens for effekterne ofte. Vi har anvendt en systematisk forskningsstrategi langs Øle Å’s øvre løb på Bornholm, hvor den...

  3. Le Prométhée enchaîné de Camus

    DEFF Research Database (Denmark)

    Lund, Hans Peter

    2008-01-01

    Et hidtil upåagtet manuskript af Albert Camus, "Den lænkede Prometheus", efter Aischylos, præsenteres og gennemgås i forhold til forlægget. Dets relevans for revolte-temaet i Camus' forfatterskab påvises, og dette tema perspektiveres i forhold til Hölderlins Empedokles, som Camus læste, til hans...

  4. ”I love my Negro nose”: Beyoncé, Kendrick Lamar og USA's nye Black Power-bevægelse

    DEFF Research Database (Denmark)

    Bjerre, Thomas Ærvold

    2016-01-01

    Placerer Beyoncés Super Bowl-optræden og Kendrick Lamars Grammy-optræden i en historisk/kulturel ramme om den afroamerikansk higen efter at få ejerskab over deres egne fortællinger, og postulerer at Beyoncé og Kendrick Lamar har sat nye standarder for afroamerikansk fortællekunst i det brede offe...

  5. Støbeforme af sten fra middelalderen

    DEFF Research Database (Denmark)

    Søvsø, Mette Højmark; Neiß, Michael; Jensen, Anne Juul

    2015-01-01

    religiøse souvenirs i Europa. Der findes mange bevarede genstande, også i Danmark, men sporene efter selve produktionen er sjældne. Genstandene blev typisk støbt i stenforme, som kendes fra spredte fund i Danmark. I Ribe er efterhånden fundet syv fragmenter af sådanne forme, som viser, at der har fundet...

  6. Contemplation at Last Sight

    DEFF Research Database (Denmark)

    Reeh, Henrik

    2015-01-01

    Pr. 1. juli 2015 gik de såkaldte klippekort ud af brug efter i mere end fyrre år at have formidlet mellem individ, offentlig transport og byrum i København og hele hovedstadsregionen. Undersøgelsen rettes især mod de automater, som har stået for afstemplingen af klippekortene. Disse automater - a...

  7. Kontanthjælpsmodtagerne i 2006

    DEFF Research Database (Denmark)

    Bach, Henning Bjerregaard; Nærvig Petersen, Kirstine

    Sagsbehandlerne i kommunerne har i et par år indplaceret kontanthjælpsmodtagerne i matchkategorier alt efter, hvor arbejdsmarkedsparate de er. Denne rapport beskriver ud fra godt 1.800 telefoninterview kontanthjælpsmodtagernes egen vurdering af bl.a. arbejdsevne og økonomiske situation. En stor del...... økonomiske situation er stort set uændret i forhold til 2000....

  8. Bekæmpelse af elmesyge

    DEFF Research Database (Denmark)

    Thomsen, Iben Margrete; Kristoffersen, Palle; Ravn, Hans Peter

    2004-01-01

    Elmesygen kom til Danmark i 1970’erne. Efter 1985 er udbredelsen gået stærkt, og elmesygen har været katastrofal for bestanden af bytræer og træer i landskabet. Bekæmpelse består fortrinsvis af sanering, dvs. fjernelse af syge og billeangrebne træer inden 1. maj....

  9. Diaspora. Somalia er ved at vågne op - overalt

    DEFF Research Database (Denmark)

    Michelsen, Anders Ib; Farah, Abdulkadir Osman; Farah Aden, Mahad

    2013-01-01

    I efteråret 2012 fik Somalia for første gang en parlamentsformand, en præsident og en statsminister fra civilsamfundet. Den føderale regering beskyttes af ca. 18.000 afrikanske tropper fra Uganda, Kenya mv. Ekstremistiske grupper er i defensiven, men ikke nedkæmpet. 6. marts 2013 ophævede Sikkerh...

  10. Cancer Mortality in People Treated with Antidepressants before Cancer Diagnosis

    DEFF Research Database (Denmark)

    Sun, Yuelian; Vedsted, Peter; Fenger-Grøn, Morten

    2015-01-01

    Depression forekommer ofte efter en kræftdiagnose og forbindes med øget mortalitet. Det er dog uvist, om depression i perioden før en kræftdiagnose også påvirker mortaliteten. Dette studie undersøger mortaliteten hos patienter, som blev behandlet med antidepressiv medicin før en kræftdiagnose...

  11. Becifringsklaver 6

    DEFF Research Database (Denmark)

    Olsen, Jens Stig

    Bogen er sjette og sidste bind i en serie, som grundigt behandler det fænomen at spille klaver efter becifring. Bøgerne er lærebøger, som primært er beregnet for studerende på læreruddannelsens musiklinie, universitet, konservatorie og andre musikuddannelser. Bøgerne kan dog også anvendes af børn...

  12. Argumentationsanalyse. Grundtræk af en modulær sprogvidenskabelig tilgang

    DEFF Research Database (Denmark)

    Nølke, Henning

    1998-01-01

    Artiklen argumenterer for, at egentlig lingvistisk teori bør være en integreret del af argumentationsteori og giver grundtrækkene af en modulær tilgang, der anvender instruktionel (i modsætning til repræsentationel) og argumentativ (i modsætning til referentiel) semantik. Efter en kort præsentati...... Ducrot....

  13. Book review

    DEFF Research Database (Denmark)

    Jensen, Niels Rosendal

    2014-01-01

    Anmeldelsen gennemgår Colette Bec's analyse af fransk sociallovgivning fra 1890'erne til 1980'erne. Den fremhæver især, at Bec's forklaring på krisen i socialpolitikken ikke kun trækker på eksterne faktorer, men derimod lægger vægt på, at selve socialpolitikken efter 1945 var udtryk for indbygged...

  14. Behandling af digital dermatitis på KFC

    DEFF Research Database (Denmark)

    Krogh, Kenneth; Thomsen, Peter

    2008-01-01

    På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008...

  15. Den hule mur

    DEFF Research Database (Denmark)

    Beim, Anne; Dahl, Torben; Sørensen, Peter

    1992-01-01

    Rapporten søger at afdække de bagvedliggende årsager til murværkets problemer i begyndelsen af 1990'erne. Efter en nærmere analyse af problemområderne tid og økonomi, bygningsfysik, bæring, isolering, og udvendig overflade peges på fem mulige udviklingsveje, samt nødvendigheden af at udvikle og a...

  16. Mystery shopping på Møn

    DEFF Research Database (Denmark)

    Kvistgaard, Peter; Smed, Karina Madsen

    2005-01-01

    betragtninger ud af, som vil blive præsenteret i løbet af efteråret 2005 sammen med de øvrige resulatater fra den store undersøgelse af turisters og lokales opfattelse af de mønske oplevelser. Men hvad er mystery shopping egentlig, hvordan kan instrumentet bruges, og kan det bruges i destinationsudvikling? Det...

  17. Professionel praksis i botilbud for mennesker med udviklingshæmning

    DEFF Research Database (Denmark)

    Engen, Mie

    I dag varetager man i Danmark hovedsageligt omsorgen for mennesker med udviklingshæmning, der har behov for hjælp og støtte på døgnbasis, i § 107/108 boformer oprettet efter Lov om Social Service og Almenboliglovens § 105. Formålet med den professionelle praksis i boformerne er at varetage disse ...

  18. East African Taarab as a contemporary mediator of the diversity and vitality of a musical tradition within Islamic Culture

    DEFF Research Database (Denmark)

    Kirkegaard, Annemette

    2007-01-01

    Artiklen diskuterer hvordan musikkulturen, taarab, i Zanzibar gennem en snart ethundrede år lang periode har været i en fortsat forhandling mellem et religiøst og et sekulært meningsindhold. Gennem tiden efter østatens selvstændighed i 1963 og frem til begyndelsen af det 21. århundrede har disse ...

  19. Forskningsbibliotekerne får travlt, hvis den nationale Open Access strategi skal lykkes

    DEFF Research Database (Denmark)

    Ibanez, Karen Sofie Hytteballe; Sandfær, Anne

    2014-01-01

    Med nedsættelsen af en national styregruppe for Open Access (OA) ser der endelig ud til at ske noget på den front i Danmark. Uddannelses og Forskningsministeriet har, efter at have anbefalinger liggende i skuffen i flere år, nu endelig meldt en national strategi ud. Målet er 80% grøn OA i 2017 og...

  20. Tilgængelige sammenbyggede boliger - indledende spørgsmål

    DEFF Research Database (Denmark)

    Ginnerup, Søren

    , at sammenbyggede boliger lever op til krav om tilgængelighed i både bygningsreglementet (BR10) og almenboligloven, hvis boligerne er en almen bebyggelse. Anvisningen gælder også for bygninger udført efter BR15, da der i forhold til BR10 ikke er ændret i bestemmelserne, som anvisningen knytter sig til. Anvisningen...

  1. Altmark, Article 86(2) and Public Service Broadcasting

    DEFF Research Database (Denmark)

    Mortensen, Frands

    2008-01-01

    En analyse af EU-Kommissionens 17 Beslutninger angående statsstøtte til Public Service Broadcasting, der er truffet efter afsigelse af Altmark-dommen i juli 2003. Kommissionen har i alle tilfælde først analyseret om de fire Altmark-krav er opfyldt, og det er aldrig tilfældet. dernæst har den godk...

  2. Regulation and risk assessment of nanomaterials

    DEFF Research Database (Denmark)

    Hansen, Steffen Foss

    Nanoteknologi er den seneste i rækken af teknologier udråbt til at indvarsle en ny industriel æra. Nuværende og fremtidige anvendelser af nanomaterialer forventes at have store sociale and miljømæssige fordele, men der er blevet rejst bekymring omkring uønskede effekter af nanomaterialer efter et...

  3. Firmaets Største Bedrift

    DEFF Research Database (Denmark)

    Hansen, Peer Henrik

    fortæller, hvordan de tidligere modstandsfolk Arne Sejr og Niels Frommelt få år efter befrielsen etablerede deres såkaldte Firma for med støtte fra ledende danske politikere, Forsvarets Efterretningstjeneste og CIA at organisere en hemmelig krig mod Sovjetunionens danske støtter. Meget tyder på, at både...

  4. Forbud og skjult netværksarbejde i gymnasieskolen

    DEFF Research Database (Denmark)

    Tække, Jesper; Paulsen, Michael

    undervisningsfællesskabet arbejder med. En del af SME-­‐projektet har gået ud på at eksperimentere en undervisningsform uden forbud og ligegyldighed overfor medier. Dette har efter begyndelsesvanskeligheder været en succes, når vi ser på elevernes refleksive forståelse af deres opmærksomhed ift. multitasking, valg af...

  5. Ellekilde

    DEFF Research Database (Denmark)

    Iversen, Rune

    2011-01-01

    En arkæologisk udgravning foretaget i udkanten af Torslunde Landsby vest for København blotlagde i efteråret 2007 en gravplads fra det 3. og 4. årh. e.Kr. Gravpladsen bestod af i alt 30 jordfæstegrave, der for de flestes vedkommende var placeret i en halvcirkel rundt om gravpladsens ældste og cen...

  6. Svingningsteori, Bind. 2

    DEFF Research Database (Denmark)

    Nielsen, Søren R.K.

    Nærværende lærebog i ikke-lineær svingningsteori er skrevet med henblik på undervisningen i bygningsdynamik på konstruktionslinien 9. semester på Aalborg Universitetscenter. Bogens indhold er i det store og hele identisk med et sæt noter Søren R. K. Nielsen udarbejdede i efterårssemestret 1987 i ...

  7. The Afghan Way

    DEFF Research Database (Denmark)

    Vestenskov, David

    Efter mere en ti års krig skal afghanske sikkerhedsstyrker inden for de kommende år overtage ansvaret for sikkerheden i landet. Opbygningen og uddannelsen af både hæren og politiet er en af de udsendte danske soldaters primære arbejdsopgaver. Ophold ved den nu nedlagte danske TMLT -enhed i Camp B...

  8. Langtidseffekten af intervention på børns eksponering for bly

    DEFF Research Database (Denmark)

    Nielsen, Jesper Bo; Kristiansen, Jesper

    Resumé I 2003 blev der gennemført en undersøgelse (miljøprojekt nr. 845) af effekten af de tiltag, der anbefales i Miljøstyrelsens vejledning nr. 7 2000 "Rådgivning af beboere i lettere forurenede områder". Projektet viste en reduktion af eksponeringen efter interventionen i de to let forurenede ...

  9. Rådgivning og reform

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2009-01-01

    Artiklen fremhæver en række centrale punkter, som bør tages i betragtning ved rådgivning efter den store selskabsreform 2009/10, der blev vedtaget af Folketinget den 29. maj 2009 på baggrund af betænkning nr. 1498/2008 fra november 2008 samt lovforslag L 170 af 25. marts 2009. Udgivelsesdato: Jul...

  10. Klingende tidsrum

    DEFF Research Database (Denmark)

    Knakkergård, Martin

    2007-01-01

    Artiklen indledes med en kort indføring i bl.a. sammenhænge mellem notationssystemer og musikforståelse. Indføringen konstaterer, at nutiden byder på musikformer, der kun vanskeligt kan forstås på dette grundlag og åbner for en forståelse af musik som kommunikation. Efter en kort beskrivelse af n...

  11. Undtagelsestilstanden og dens judicielle efterprøvelse

    DEFF Research Database (Denmark)

    Rytter, Jens Elo

    2009-01-01

    Artiklen drøfter, hvad der skal til for at etablere en undtagelsestilstand, jf. EMRK art. 15, og om terrortruslen efter 11 september 2001 kunne siges at have etableret en sådan tilstand. Det drøftes endvidere, i hvilket omfang nationale domstole henholdsvis EMD kan og bør efterprøve de nationale...

  12. Tidsskriftet Antropologi

    DEFF Research Database (Denmark)

    VOLD. 15 år efter murens fald må vi konstatere, at Verdens voldelige orden ikke opløstes med den kolde krigs afslutning. Verden er ikke blevet mere fredelig, og håbet kom til den endelige symbolske afslutning den 11. september 2001. Siden da har ”Krigen mod terror” skabt nye konflikter og krige i...

  13. Hans mening om hendes krop

    DEFF Research Database (Denmark)

    Scheuer, Jann

    2017-01-01

    Bidraget handler om søgninger i danske tekstkorpusser efter 'hendes' hhv. 'hans' + nominal inden for en afstand af to ord. Det er ved hjælp af søgninger i big data undersøgt hvad der knyttes til hende og ham, hvad deres ejendom er: hendes lejlighed o.l. og hvilke attributter de tilskrives hans fi...

  14. En EU-strategi for integreret hjemmetræning

    DEFF Research Database (Denmark)

    Larsen, Torben

    i 3 forskellige EU-lande, 4) Pilotforsøg med TeleRehab som supplement til den direkte hjemmetræning og 5) Sammenfatning af evidensgrundlaget i en MTV efter den danske 4-grenede model.    Baseret på en SWOT-analyse satses der på implementering af forsøgsresultaterne via en meso-strategi, hvor et...

  15. Web 2.0 - Lær dog af Obama!

    DEFF Research Database (Denmark)

    Ivang, Reimer

    2009-01-01

    At Obama vandt 2008 præsidentvalget ved at anvende web 2.0 teknologier, er ingen hemmelighed. Men hvordan gjorde han det? Og hvorfor var det så effektfuldt? Dette blogindlæg ser Obama efter i kortene, og kortlægger den læring, som danske virksomheder kan høste af den fantastiske strategi, Obama-k...

  16. Stormløb mod grænsen

    DEFF Research Database (Denmark)

    Holm, Isak Winkel

    Franz Kafka blev berømt i årene efter Anden Verdenskrig, i skyggen af atomtruslen og det 20. århundredes totalitarisme. Dengang lå det lige for at fortolke hans forfatterskab som et budskab fra en "kafkask" verden hvor det magtesløse menneske uvægerligt må bukke under for meningsløse bureaukratis...

  17. Extending the Versatility of Chemical Microchips by Improved Integration of Functional Elements

    DEFF Research Database (Denmark)

    Snakenborg, Detlef

    2007-01-01

    Ideen bag Lab-on-a-chip systemer er at integrere alle nødvendige funktioner for udførelsen af en komplet biokemisk analyse i et enkelt apparat. Efter næsten to årtiers forskning er antallet af tilgængelige teknologier der kombinerer de forskellige kerne funktioner, såsom mikrofluid håndtering, pr...

  18. Udvikling af en internetsøgestrategi til identifikation af ny medicinsk teknologi inden for prostatacancer

    DEFF Research Database (Denmark)

    Thygesen, Marianne; Vondeling, Hindrik; Douw, Karla

    2007-01-01

    internetsider efter efficiens. Her er efficiens forstået som mindst antal minutter brugt pr. fund af information om en ny væsentlig medicinsk teknologi. Resultater: Strategien består af ti sider, som bør benyttes i følgende rækkefølge: YahooHealth, DoctorsGuide, The National Electronic Library for Medicines...

  19. Messedeltagelse: Til nytte eller besvær?

    DEFF Research Database (Denmark)

    Hansen, Kåre

    2000-01-01

    Nytten af messedeltagelse skal vurderes på flere parametre end salg. Profilering og opbygning af relationer opfattes af udstillerne som det vigtigste ved at deltage på messer. Og for at opnå dette kræves der planlægning, erfaring og engagement både før, under og efter messen. Det er hovedbudskabet...

  20. Complicated grief and need for professional support in family caregivers of cancer patients in palliative care: a longitudinal cohort study

    DEFF Research Database (Denmark)

    Guldin, Mai-Britt; Vedsted, Peter; Zachariae, Robert

    2012-01-01

    Internationale studier om sorg viser, at op mod 15-20 % af sørgende går ind i et problematisk forløb med langvarig og pinefuld sorg. Langvarig sorg kaldes kompliceret sorg og er karakteriseret ved et syndrom af vedvarende høj følelsesmæssig intensitet efter dødsfaldet, psykopatologiske reaktioner...

  1. Hvor vigtigt er det danske veterinære beredskab?

    DEFF Research Database (Denmark)

    Hansen, Henning Otte; Christensen, Tove; Denver, Sigrid

    2017-01-01

    formålet at få belyst vigtigheden af det veterinære beredskab og markedsføringen heraf for henholdsvis adgang til eksportmarkeder (inden for og uden for EU), og for genetablering af markedsadgang efter et udbrud af mund- og klovesyge (MKS). Baseret på interviews m.m. med en række nøglepersoner belyses...

  2. Island i skrivende danskeres drømme

    DEFF Research Database (Denmark)

    Skyum-Nielsen, Erik

    2015-01-01

    and travelogues, but also in a single short story as well as texts by prominent poets. As his first stop, he has chosen Harald Kidde's novel Helten (The Hero) from 1912 and as his last Lars Frost's novel Smukke biler efter krigen (Beautiful cars after the War, 2004), thus entering the 21st Century. The Danish...

  3. Regninput til regnvandsdisponering i Aarhus Vands forsyningsområde

    DEFF Research Database (Denmark)

    Thorndahl, Søren Liedtke

    Dette tekniske memorandum er udarbejdet at Søren Thorndahl, Aalborg Universitet til brug i den Regnvandsdisponeringsplanlægning som pågår hos Aarhus Vand i efteråret 2017. Arbejdet er udført som en del af udviklingsprojektet KLIMAKS - Klimafremskrivning af målt nedbør til afløbsteknisk anvendelse...

  4. Luftkvalitet langs motorveje

    DEFF Research Database (Denmark)

    Jensen, S. S.; Løfstrøm, P.; Berkowicz, R.

    Denne rapport beskriver måle- og modelresultater. Målekampagnen blev gennemført langs Køge Bugt motorvejen ved Greve for en 3 måneders periode i efteråret 2003, hvor der blev målt NOx (NO og NO2) i forskellige afstande af motorvejen. Der er endvidere opstillet en luftkvalitetsmodel, som beskriver...

  5. Tilgængelige hotelværelser

    DEFF Research Database (Denmark)

    Grangaard, Sidse; Mathiasen, Nanet; Sørensen, Lars Schiøtt

    Denne rapport undersøger hotelbranchens oplevelse af balancen mellem udbuddet efterspørgslen på tilgængelige hotelværelser i Danmark. Undersøgelsen indikerer, at danske hoteller bygget efter 2008 tilbyder tilgængelige hotelværelser. Der er dog stor forskel på, om tilgængelighed er en del af...

  6. Er sektorvalget også kønsopdelt blandt kvinder og mænd med samme uddannelse?

    DEFF Research Database (Denmark)

    Larsen, Mona; Holt, Helle; Larsen, Malene Rode

    2017-01-01

    private sektor end kvinder. For nogle uddannelser opstår kønsforskellen umiddelbart efter endt uddannelse, mens den for andre uddannelser først opstår i de efterfølgende år. Forskellige (forestillinger om) sektorspecifikke arbejdsvilkår kan ifølge resultaterne i denne artikel være en af forklaringerne på...

  7. Tidlig intensiv rehabilitering efter meget svaer traumatisk hjerneskade. Opfølgning seks måneder efter udskrivelsen

    DEFF Research Database (Denmark)

    Liebach, Annette; Nordenbo, Annette Mosbaek; Engberg, Aase Worsaae

    2007-01-01

    In September 2000 the Brain Injury Unit at Hvidovre Hospital was established, offering subacute intensive rehabilitation to patients with severe traumatic brain injury. Uptake area: Eastern part of Denmark, the Faroe Islands and Greenland. Outcome 6 months after discharge is presented for patient...

  8. Ethiopian Pharmaceutical Journal - Vol 22, No 1 (2004)

    African Journals Online (AJOL)

    Formulation and evaluation of sustained release paracetamol peroral matrix tablets: optimisation and in vitro evaluation · EMAIL FULL TEXT EMAIL FULL TEXT ... Communication: Matrix type transdermal drug delivery systems of metoprolol tartrate: skin toxicity and in vivo characterization · EMAIL FULL TEXT EMAIL FULL ...

  9. Clinical management of pediatric achalasia

    NARCIS (Netherlands)

    van Lennep, Marinde; van Wijk, Michiel P.; Omari, Taher I.; Benninga, Marc A.; Singendonk, Maartje M. J.

    2018-01-01

    Achalasia is a rare esophageal motility disorder. Much of the literature is based on the adult population. In adults, guidance of therapeutic approach by manometric findings has led to improvement in patient outcome. Promising results have been achieved with novel therapies such as PerOral

  10. Perorale endoscopische myotomie bij achalasie

    NARCIS (Netherlands)

    Ponds, Fraukje A. M.; Smout, André J. P. M.; Bredenoord, Albert J.; Fockens, Paul

    2015-01-01

    The treatment of patients with achalasia is complex due to a considerably high recurrence rate and risk of treatment-related complications. The per-oral endoscopic myotomy (POEM) is a new endoscopic technique that combines the benefits of a minimally invasive endoscopic procedure with the efficacy

  11. A functional cra gene is required for Salmonella enterica serovar typhimurium virulence in BALB/c mice

    DEFF Research Database (Denmark)

    Allen, J. H.; Utley, M.; Van den Bosch, H.

    2000-01-01

    A minitransposon mutant of Salmonella enterica serovar Typhimurium SR-11, SR-11 Fad(-), is unable to utilize gluconeogenic substrates as carbon sources and is avirulent and immunogenic when administered perorally to BALB/c mice (M. J. Utley et al., FEMS Microbiol. Lett., 163:129-134, 1998). Here,...

  12. causes of death among the caesars (27 bc-ad 476) 1. introduction

    African Journals Online (AJOL)

    perors in the Early Empire ruled for a longer period (12,7 years as against 6,0 years) ... During the Early Empire 55,6% of the emperors died of natural causes or illness, as ..... a war against the Goths (making him the first Roman emperor to die.

  13. 51Cr-ethylenediaminetetraacetic acid absorption test

    International Nuclear Information System (INIS)

    Aabakken, L.

    1989-01-01

    The 51 Cr-ethylenediaminetetraacetic acid (EDTA) absorption test was evaluated in 83 healthy, male volunteers. Base-line 24 h excretion after peroral administration ranged from 0.88% to 7.96%, with a higher median absorption than reported by most authors (2.45%). However, the reproducibility and stability of the method and the reproducibility of the results were satisfactory. Urinary excretion after intraduodenal installation (n=18) was comparable to that seen after peroral test dose administration, indicating a limited significance of gastric 51 Cr-EDTA absorption under normal conditions. In 16 subjects a single intake of alcohol immediately before the test gave a modest and short-lasting increase in 51 Cr-EDTA absorption. No correlation was seen to body mass index, creatinine clearance, urinary volume, or small-bowel transit time, possibly reducing the number of confounding factors in the evaluation of absorption data. A small but significant negative correlation was, however, found to body surface area and age

  14. Emergency CT in blunt abdominal trauma of multiple injury patients

    International Nuclear Information System (INIS)

    Kinnunen, J.; Kivioja, A.; Poussa, K.; Laasonen, E.M.

    1994-01-01

    Multiple injury patients with blunt abdominal trauma (n = 110) were examined by abdominal CT. An i.v., but not peroral, contrast medium was used, thereby eliminating the delay caused by administering peroral contrast medium and any subsequent delay in making the diagnoses and beginning operative treatment. Eighteen patients underwent emergency laparotomy after the initial CT examination. The preoperative CT findings were compared to the laparotomy findings. CT revealed all but one of the severe parenchymal organ lesions requiring surgery. The one liver laceration that went undetected had caused hemoperitoneum, which was diagnosed by CT. The bowel and mesenteric lesions presented as intra-abdominal blood, and the hemoperitoneum was discovered in every patient with these lesions. Fourteen patients also initially had positive abdominal CT findings; 10 of them underwent an additional abdominal CT within 3 days, but the repeat studies did not reveal any lesions in need of surgery. Omission of the oral contrast medium did not jeopardize making the essential diagnoses, but it did save time. (orig.)

  15. Lars Larsen - en bombe i underbevidstheden. Et halvt år med reklame i TV2

    Directory of Open Access Journals (Sweden)

    Bendt Nygaard

    1989-08-01

    Full Text Available Efter mange års diskussion for og imod fik vi endelig reklamer i dansk TV. Redaktionen har bedt Bendt Nygaard anmelde det første halve års reklamer. Det sker ved at inddele dem i typer, de såkaldte formater. Og ved at trække den vist nok mest atypiske frem. Nygaard begrunder selv hvorfor.

  16. 2014-reformen af EU’s fælles landbrugspolitik og implikationer for Danmark

    DEFF Research Database (Denmark)

    Lind, Kim Martin Hjorth; Kærgård, Niels; Zobbe, Henrik

    2014-01-01

    Den samlede støtte til landbruget i EU omregnet til faste priser vil efter de seneste reformer være gradvist faldende, men ikke mere end, at konsekvenserne er til at overskue. Langt større konsekvenser har udjævningen af støtten både mellem lande og internt i landene. Særligt kvægsektoren i Danmark...

  17. Difficulties in swallowing and eating following acquired brain injury

    DEFF Research Database (Denmark)

    Kjærsgaard, Annette

    på grund af fejlsynkning, hvilket efterlod syv patienter til analysen. Fire af disse udviklede lungebetændelse inden for 10 dage efter initiering af oralt indtag; en patient evalueret ved hjælp af F.O.T.T. og tre patienter ved hjælp af FEES. Studie I (artikel II) afdækker, om der er forskel i...

  18. Becifringsklaver 4

    DEFF Research Database (Denmark)

    Olsen, Jens Stig

    Bogen er fjerde bind i en serie på seks, som grundigt behandler det fænomen at spille klaver efter becifring. Bøgerne er lærebøger, som primært er beregnet for studerende på læreruddannelsens musiklinie, universitet, konservatorie og andre musikuddannelser. Bøgerne kan dog også anvendes af børn i...

  19. Borgring sæson 1 - Vold, brand og ødelæggelse

    DEFF Research Database (Denmark)

    Ulriksen, Jens; Christensen, Jonas; Holm, Nanna

    2017-01-01

    Sæson 1 af Borgringprojektet er overstået – i hvert fald i marken. Efter måneders planlægning, både blandt arkæologer og formidlingsfolk, kunne Hendes Majestæt Dronningen officielt åbne den publikumsorienterede del af forskningsprojektet den sidste dag i maj 2016. Gennem de følgende tre måneder bl...

  20. Anders og vandslangen

    DEFF Research Database (Denmark)

    Søndergaard, Dorte Marie

    2009-01-01

    Hvordan går det til, at Anders havner i hjørnet af bruserummet efter idrætstimerne, mens de andre drenge i klassen spuler ham med koldt vand fra vandslangen på væggen? Er det Anders, der er noget galt med? Eller er det de andre drenge? Eller er fejlen i virkeligheden pedellens? Han har jo skruet ...

  1. THAILAND - Hvad foregår der?

    DEFF Research Database (Denmark)

    Schmidt, Johannes Dragsbæk

    2010-01-01

    Efter flere måneders uroligheder mellem opposition og regeringsstyrker, stormede militæret i går de besatte områder i Bangkok. Flere af demonstranternes – de såkaldte ”Rødskjorter”s – ledere blev anholdt; spørgsmålet er, om det vil resultere i en afslutning af kampene? RÆSON har spurgt Johannes D...

  2. Med 3. styrmand på Danmark-Ekspeditionen

    DEFF Research Database (Denmark)

    ekspeditionsliv var uden radio, GPS, telefon og andre moderne bekvemmeligheder. De var afskåret fra omverdenen. Kort sagt. Bendix Thostrup (1876-1945) er født i Viborg og er fra de gamle sejlskibes tid. Han fik sine styrmandspapirer i marinen i 1902 og opsøgte i efteråret 1905, som en af de første ekspeditionens...

  3. Den Blå Drage

    DEFF Research Database (Denmark)

    Ingerslev, Gitte Holten

    Denne publikation i serien Læselyst tjener tre formål. Den evaluerer læseprojektet Den blå drage i efteråret 2004 på Byskolen i Svendborg ? et projekt ledet af forfatteren Josefine Ottesen. Desuden gøres der rede for nogle af de teorier der støtter og begrunder arbejdsmåde og resultater i projektet...

  4. De internationale markeder for dansk svinekød

    DEFF Research Database (Denmark)

    Nielsen, Niels Asger

    2005-01-01

    En af de parametre, som har størst betydning for, om efterspørgselen efter dansk svinekød kan opretholdes eller øges i de kommende år er, hvordan ønsker og behov hos de endelige forbrugere udvikler sig i fremtiden. Det kan vi af gode grunde ikke vide præcist, men vi kan med udgangspunkt i blandt ...

  5. Anatomisk forståelse 2

    DEFF Research Database (Denmark)

    Zetterberg, Lars Gøran; Vejle-Sørensen, Jens Kristian; Debess, Jeanne Elisabeth

    2014-01-01

    Formål: At afprøve om et træningsforløb baseret på UL-skanning af fantom kan forbedre radiografstuderendes rumlige anatomiske forståelse. I efterårssemesteret 2012 blev et pilotstudie med samme formål gennemført på Radiografuddannelsen, UCN. Det har ikke været muligt at finde andre studier, som u...

  6. Becifringsklaver 2

    DEFF Research Database (Denmark)

    Olsen, Jens Stig

    Bogen er andet bind i en serie på seks, som grundigt behandler det fænomen at spille klaver efter becifring. Bøgerne er lærebøger, som primært er beregnet for studerende på læreruddannelsens musiklinie, universitet, konservatorie og andre musikuddannelser. Bøgerne kan dog også anvendes af børn i ...

  7. Lediges motivation og forsørgelse

    DEFF Research Database (Denmark)

    Bach, Henning Bjerregaard

    Denne rapport belyser sammenhængen mellem lediges tilkendegivelser om deres interesse og bestræbelser for at få et arbejde og deres efterfølgende selvforsørgelse i et tidsrum på op til 2 år efter tilkendegivelserne. Selvforsørgelse defineres som et tidsrum på mindst 4 uger, hvor ledige ikke længe...

  8. Magkänslans anatomi

    DEFF Research Database (Denmark)

    Ahlström, Kristoffer

    Varför dog 1500 personer i onödan i biltrafiken efter den 11 september 2001? Vad har FBI-agenter gemensamt med barn till alkoholister? Och vad fick författaren George Orwell att börja utöva svart magi? Magkänslans anatomi är en fascinerande kartläggning av de psykologiska mekanismer som ligger...

  9. Becifringsklaver 1

    DEFF Research Database (Denmark)

    Olsen, Jens Stig

    Bogen er første bind i en serie på seks, som grundigt behandler det fænomen at spille klaver efter becifring. Bøgerne er lærebøger, som primært er beregnet for studerende på læreruddannelsens musiklinie, universitet, konservatorie og andre musikuddannelser. Bøgerne kan dog også anvendes af børn i...

  10. Effektmålinger på Wave Star i Nissum Bredning

    DEFF Research Database (Denmark)

    Frigaard, Peter; Andersen, Thomas Lykke

    Wave Star test-maskinen i Nissum Bredning blev sat i kontinuerlig drift den 24. juli 2006. Igennem de seneste 2½ år er den producerede effekt blevet målt kontinuert og kun med mindre afbrydelser. Målingerne dækker over drift på alle årstiderne (forår, sommer, efterår, vinter) i et meget omskiftel...

  11. Genetablering af skov på stormfaldsarealer ved naturlig foryngelse

    DEFF Research Database (Denmark)

    Brunner, Andreas; Petersen, Flemming Rune

    foryngelse i forsøget blev registreret intensivt de første fire år efter stormfaldet i 1999. Resultaterne er foreløbige på grund af den korte tidshorisont, men viser, at det er muligt at genetablere skov på stormfaldsarealer ved hjælp af naturlig foryngelse. Foryngelsen kan i vid udstrækning bygge på de...

  12. Er der sammenhæng mellem foderudnyttelse, aktivitet og sundhed?

    DEFF Research Database (Denmark)

    Damgaard, Birthe Marie; Hansen, Steffen W

    2010-01-01

    Gennem de senere år er minken blevet tungere år efter år, og undersøgelser har vist, at det er muligt at øge foderudnyttelsen gennem avl. Formålet med denne undersøgelse var at belyse aktivitet, kropsvægt og immunstatus hos mink med høj og lav residual foderindtag (RFI) ved restriktiv og ad libit...

  13. Liv i universet

    DEFF Research Database (Denmark)

    Rasmussen, Ib Lundgaard

    Liv i universet - er vi alene? Dette store spørgsmål forsøger den nye videnskab astrobiologi at svare på. Udviklingen af liv her på Jorden danner nemlig grundlag for vores søgen efter liv andre steder. Gennem studiet af livets opståen og udvikling på Jorden kan man opstille retningslinjer for...

  14. Når døde børn er livets gave

    DEFF Research Database (Denmark)

    Jensen, Anja Marie Bornø

    2008-01-01

    Det er kvinder, især mødre til organdonorer, der gennem en særlig praktisering af “moderskab” sætter dagsordenen for den organisatoriske støtte og opfølgning, der tilbydes alle pårørende til organdonorer i USA i tiden efter samtykket til organdonation. Men hvordan kommer dette partikulære modersk...

  15. Filologi eller formalisme. Litteraturvidenskaben mellem Skylla og Karybdis?

    DEFF Research Database (Denmark)

    Hoffmann, Birthe

    Artiklen er en diskussion af forskellige veje til forståelsen af litteratur, som af historiske og institutionelle grunde i vid udstrækning har været adskilt i Danmark. Efter et historisk rids følger et forsøg på at forene den formalistiske og den filologiske tilgang i en analyse af J. W. v. Goethes...

  16. Øger et anhængertræk risikoen for piskesmæld i bagendekollisioner?

    DEFF Research Database (Denmark)

    Olesen, Anne Vingaard; Lahrmann, Harry Spaabæk

    passagerer. En bagendekollision er imidlertid også i nyere biler forbundet med en vis risiko for piskesmæld. Litteraturen estimerer en risiko på mindst 15% for at få mén efter en bagendekollision (Sterner, 2004). Hypotesen i dette studie er, at et anhængertræk påmonteret den påkørte bil vil interagere...... negativt med kollisionszonen og medføre, at bagagerummet helt eller delvist ikke krøller sammen. Effekten af trækkrogen ville derfor blive en øget risiko for piskesmæld ud over, hvad der allerede er kendt ved bagendekollisioner. Et svensk studie nævner en forøget risiko på 22% (Krafft et al., 2000). Ud...... for en køns- og aldersmatchet kontrolbefolkning. Vi fandt umiddelbart ikke evidens for, at piskesmældsofre er dårligere socialt stillet end andre. Diskussion Dette studie viser, at et anhængertræk på påkørte bil i en bagendekollision ikke øger risikoen for piskesmæld – heller ikke efter korrektion...

  17. Danske duehøges populationsøkologi og forvaltning

    DEFF Research Database (Denmark)

    Drachmann, J.; Nielsen, J. T.

    Efter at duehøgen blev helårsfredet i 1967 gik antallet af duehøge frem i Danmark igennem 1970erne og 1980erne, men i løbet af 1990erne er populationen atter gået tilbage flere steder i Danmark. I Vendsyssel gik duehøgepo-pu-la-tio-nen således frem fra 31 ynglepar i 1977 til 72 par i 1994...... seneste års tilbagegang i den danske duehøgepo-pu-la-tion. Duehøgs reproduktion Duehøgens ungeproduktion kunne relateres til hunnens alder i 951 yngleforsøg, og til hannens alder i 561 yngleforsøg. Den aldersspecifikke ungeproduktion steg med såvel han- som hunalder, men kun den aldersafhængige...... duehøgens byt-te steg signifikant fra midten af 1990erne bå-de i og uden for yngletiden, og stigningen hang sammen med en stigende mængde fasaner i Vendsyssel i løbet af 1990erne da interessen for at udsætte fasaner til jagt i undersøgelsesområdet nemlig steg markant efter 1993. Stigningen i antallet af...

  18. Mænd med rejsningsbesvær efter radikal prostatektomi bør behandles efter sædvanlige retningslinjer

    DEFF Research Database (Denmark)

    Fode, Mikkel; Hansen, Rikke Bølling; Maigaard, Thomas

    2014-01-01

    Penile rehabilitation programmes aim to improve long-term sexual function after nerve-sparing radical prostatectomy. Programmes aim to improve cavernous oxygenation to avoid structural damage in penile tissue. Especially, daily use of phosphodiesterase type 5 (PDE5) inhibitors has been studied. T......, urethral suppositories and penile implants....

  19. Mænd med rejsningsbesvær efter radikal prostatektomi bør behandles efter sædvanlige retningslinjer

    DEFF Research Database (Denmark)

    Fode, Mikkel; Hansen, Rikke Bølling; Maigaard, Thomas

    2015-01-01

    Penile rehabilitation programmes aim to improve long-term sexual function after nerve-sparing radical prostatectomy. Programmes aim to improve cavernous oxygenation to avoid structural damage in penile tissue. Especially, daily use of phosphodiesterase type 5 (PDE5) inhibitors has been studied. T......, urethral suppositories and penile implants....

  20. Inorganic and organic mercury chloride toxicity to Coturnix: Sensitivity related to age and quantal assessment of physiologic responses

    Science.gov (United States)

    Hill, E.F.

    1982-01-01

    The toxicities of mercuric chloride (HgCl(,2)) and methylmercuric chloride (CH(,3)HgCl) were compared for coturnix (Coturnix coturnix japonica) from hatching to adulthood. Comparisons were based on: (1) Median lethal dosages (LD50) derived by administering single peroral and single intramuscular dosages of mercury, (2) median lethal concentrations (LC50) derived by feeding mercury for 5 days, (3) median toxic concentrations (TC50) derived by feeding mercury 9 weeks and measuring plasma enzyme activity, plasma electrolytes, and other blood constituents, and (4) transient changes of various blood chemistries following a single peroral dose of mercury. Acute peroral and intramuscular LD50s for HgCl(,2) and CH(,3)HgCl increased by two- to threefold for coturnix chicks from hatching to 4 weeks of age. Concomitantly, the LC50s also increased, but the important difference between test procedures was that with both single dose routes of exposure the toxicity ratios, i.e., HgCl(,2)/CH(,3)HgCl, at each age were about 2 to 2.5 compared to about 100 for the LC50s. For example, at 2 weeks of age the peroral LD50s for HgCl(,2) and CH(,3)HgCl were 42 and 18 mg/kg; the dietary LC50s were 5086 and 47 ppm for HgCl(,2) and CH(,3)HgCl. The 9 week feeding trial was not associated with gross effects from either HgCl(,2) at 0.5 to 32 ppm or CH(,3)HgCl at 0.125 to 8 ppm. However, subtle responses were detected for the plasma enzymes aspartate aminotransferase, lactate dehydrogenase, and ornithine carbamoyl transferase and could be quantified by probit analysis. This quantal procedure was based on establishment of a normal value for each enzyme and classing outliers as respondents. A 'hazard index' based on the TC50 for an enzyme divided by the LD50 or LC50 was introduced. The single oral dosages of HgCl(,2) and CH(,3)HgCl showed that ratios of alanine aminotransferase, lactate dehydrogenase, and orinthine carbamoyl transferase for the liver and kidneys of adult coturnix were opposite from