WorldWideScience

Sample records for edge localised ideal

  1. Cutting Edge Localisation in an Edge Profile Milling Head

    NARCIS (Netherlands)

    Fernandez Robles, Laura; Azzopardi, George; Alegre, Enrique; Petkov, Nicolai

    2015-01-01

    Wear evaluation of cutting tools is a key issue for prolonging their lifetime and ensuring high quality of products. In this paper, we present a method for the effective localisation of cutting edges of inserts in digital images of an edge profile milling head. We introduce a new image data set of

  2. The Reconstruction Conjecture and Edge Ideals

    Science.gov (United States)

    2008-01-01

    Given a monomial ideal I in R = k[x1, . . . , xn], we define the multigraded Betti numbers i,b of I in terms of a multigraded minimal free resolution...5.5]). We will use Hochster’s formula from Stanley–Reisner theory to study the multigraded Betti numbers of the edge ideal of a graph. We will prove...Chapter 5]), the multigraded Betti number i,b of R/I can be computed via the reduced simplicial homology of certain subcomplexes of : i,b = i,B := dimk

  3. Stability of ideal and non-ideal edge localized infernal mode

    Science.gov (United States)

    Dong, G. Q.; Liu, Y. Q.; Wang, S.; Zhang, N.; Yu, D. L.; Liu, Y.; Wang, Z. R.

    2017-11-01

    Stability of a special class of the infernal mode, i.e., the one which is localized near the plasma edge, is numerically investigated for a toroidal plasma, using the single fluid code MARS-F [Liu et al., Phys. Plasmas 7, 3681 (2000)] and magneto-hydrodynamic-kinetic hybrid code MARS-K [Liu et al., Phys. Plasmas 15, 112503 (2008)]. Unlike the peeling-ballooning instabilities, which are thought to be responsible for the onset of type-I edge localized modes, the edge localized infernal mode may be responsible for accessing certain quiescent H-mode regimes in tokamak discharges. The finite plasma pressure near the plasma edge drives this instability. The local flattening of the safety factor near a rational surface at the plasma edge region, due to the large bootstrap current contribution in H-mode plasmas, is a necessary condition for the mode instability. It is found that the plasma toroidal flow shear in the pedestal region, as well as the plasma resistivity, further destabilizes the edge localized infernal mode. The drift kinetic effects from thermal particles, on the other hand, partially stabilize the mode. The flow shear and the drift kinetic effects also modify the symmetry of the mode spectrum, by enlarging the unstable domain towards higher local qmin value. No substantial modification of the mode eigen-structure is observed by the plasma flow, resistivity, or the kinetic effects. These results can be relevant to understanding physics of certain quiescent H-mode regimes.

  4. A probabilistic verification score for contours demonstrated with idealized ice-edge forecasts

    Science.gov (United States)

    Goessling, Helge; Jung, Thomas

    2017-04-01

    We introduce a probabilistic verification score for ensemble-based forecasts of contours: the Spatial Probability Score (SPS). Defined as the spatial integral of local (Half) Brier Scores, the SPS can be considered the spatial analog of the Continuous Ranked Probability Score (CRPS). Applying the SPS to idealized seasonal ensemble forecasts of the Arctic sea-ice edge in a global coupled climate model, we demonstrate that the SPS responds properly to ensemble size, bias, and spread. When applied to individual forecasts or ensemble means (or quantiles), the SPS is reduced to the 'volume' of mismatch, in case of the ice edge corresponding to the Integrated Ice Edge Error (IIEE).

  5. Edge localized linear ideal magnetohydrodynamic instability studies in an extended-magnetohydrodynamic code

    Science.gov (United States)

    Burke, B. J.; Kruger, S. E.; Hegna, C. C.; Zhu, P.; Snyder, P. B.; Sovinec, C. R.; Howell, E. C.

    2010-03-01

    A linear benchmark between the linear ideal MHD stability codes ELITE [H. R. Wilson et al., Phys. Plasmas 9, 1277 (2002)], GATO [L. Bernard et al., Comput. Phys. Commun. 24, 377 (1981)], and the extended nonlinear magnetohydrodynamic (MHD) code, NIMROD [C. R. Sovinec et al.., J. Comput. Phys. 195, 355 (2004)] is undertaken for edge-localized (MHD) instabilities. Two ballooning-unstable, shifted-circle tokamak equilibria are compared where the stability characteristics are varied by changing the equilibrium plasma profiles. The equilibria model an H-mode plasma with a pedestal pressure profile and parallel edge currents. For both equilibria, NIMROD accurately reproduces the transition to instability (the marginally unstable mode), as well as the ideal growth spectrum for a large range of toroidal modes (n =1-20). The results use the compressible MHD model and depend on a precise representation of "ideal-like" and "vacuumlike" or "halo" regions within the code. The halo region is modeled by the introduction of a Lundquist-value profile that transitions from a large to a small value at a flux surface location outside of the pedestal region. To model an ideal-like MHD response in the core and a vacuumlike response outside the transition, separate criteria on the plasma and halo Lundquist values are required. For the benchmarked equilibria the critical Lundquist values are 108 and 103 for the ideal-like and halo regions, respectively. Notably, this gives a ratio on the order of 105, which is much larger than experimentally measured values using Te values associated with the top of the pedestal and separatrix. Excellent agreement with ELITE and GATO calculations are made when sharp boundary transitions in the resistivity are used and a small amount of physical dissipation is added for conditions very near and below marginal ideal stability.

  6. Ideal MHD stability and characteristics of edge localized modes on CFETR

    Science.gov (United States)

    Li, Ze-Yu; Chan, V. S.; Zhu, Yi-Ren; Jian, Xiang; Chen, Jia-Le; Cheng, Shi-Kui; Zhu, Ping; Xu, Xue-Qiao; Xia, Tian-Yang; Li, Guo-Qiang; Lao, L. L.; Snyder, P. B.; Wang, Xiao-Gang; the CFETR Physics Team

    2018-01-01

    Investigation on the equilibrium operation regime, its ideal magnetohydrodynamics (MHD) stability and edge localized modes (ELM) characteristics is performed for the China Fusion Engineering Test Reactor (CFETR). The CFETR operation regime study starts with a baseline scenario (R  =  5.7 m, B T  =  5 T) derived from multi-code integrated modeling, with key parameters {{β }N},{{β }T},{{β }p} varied to build a systematic database. These parameters, under profile and pedestal constraints, provide the foundation for the engineering design. The long wavelength low-n global ideal MHD stability of the CFETR baseline scenario, including the wall stabilization effect, is evaluated by GATO. It is found that the low-n core modes are stable with a wall at r/a  =  1.2. An investigation of intermediate wavelength ideal MHD modes (peeling ballooning modes) is also carried out by multi-code benchmarking, including GATO, ELITE, BOUT++ and NIMROD. A good agreement is achieved in predicting edge-localized instabilities. Nonlinear behavior of ELMs for the baseline scenario is simulated using BOUT++. A mix of grassy and type I ELMs is identified. When the size and magnetic field of CFETR are increased (R  =  6.6 m, B T  =  6 T), collisionality correspondingly increases and the instability is expected to shift to grassy ELMs.

  7. Ideal MHD Stability and Characteristics of Edge Localized Modes on CFETR

    Science.gov (United States)

    Li, Zeyu; Chan, Vincent; Xu, Xueqiao; Wang, Xiaogang; Cfetr Physics Team

    2017-10-01

    Investigation on the equilibrium operation regime, its ideal magnetohydrodynamics (MHD) stability and edge localized modes (ELM) characteristics is performed for China Fusion Engineering Test Reactor (CFETR). The CFETR operation regime study starts with a baseline scenario derived from multi-code integrated modeling, with key parameters varied to build a systematic database. These parameters, under profile and pedestal constraints, provide the foundation for engineering design. The linear stabilities of low-n and intermediate-n peeling-ballooning modes for CFETR baseline scenario are analyzed. Multi-code benchmarking, including GATO, ELITE, BOUT + + and NIMROD, demonstrated good agreement in predicting instabilities. Nonlinear behavior of ELMs for the baseline scenario is simulated using BOUT + + . Instabilities are found both at the pedestal top and inside the pedestal region, which lead to a mix of grassy and type I ELMs. Pedestal structures extending inward beyond the pedestal top are also varied to study the influence on ELM characteristic. Preliminary results on the dependence of the Type-I ELM divertor heat load scaling on machine size and pedestal pressure will also be presented. Prepared by LLNL under Contract DE-AC52-07NA27344 and National Magnetic Confinement Fusion Research Program of China (Grant No. 2014GB110003 and 2014GB107004).

  8. In situ removal of carbon contamination from a chromium-coated mirror: ideal optics to suppress higher-order harmonics in the carbon K-edge region

    Energy Technology Data Exchange (ETDEWEB)

    Toyoshima, Akio; Kikuchi, Takashi; Tanaka, Hirokazu [KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); Mase, Kazuhiko, E-mail: mase@post.kek.jp; Amemiya, Kenta [KEK, 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan); SOKENDAI (The Graduate University for Advanced Studies), 1-1 Oho, Tsukuba, Ibaraki 305-0801 (Japan)

    2015-09-26

    Carbon contamination of a chromium-coated mirror was removed by exposure to oxygen activated with non-monochromated synchrotron radiation. Higher-order harmonics of the chromium-coated mirror are much smaller than those of a gold-coated mirror in the carbon K-edge region. Carbon-free chromium-coated optics are ideal in the carbon K-edge region (280–330 eV) because the reflectivity of first-order light is larger than that of gold-coated optics while the second-order harmonics (560–660 eV) are significantly suppressed by chromium L-edge and oxygen K-edge absorption. Here, chromium-, gold- and nickel-coated mirrors have been adopted in the vacuum ultraviolet and soft X-ray branch beamline BL-13B at the Photon Factory in Tsukuba, Japan. Carbon contamination on the chromium-coated mirror was almost completely removed by exposure to oxygen at a pressure of 8 × 10{sup −2} Pa for 1 h under irradiation of non-monochromated synchrotron radiation. The pressure in the chamber recovered to the order of 10{sup −7} Pa within a few hours. The reflectivity of the chromium-coated mirror of the second-order harmonics in the carbon K-edge region (560–660 eV) was found to be a factor of 0.1–0.48 smaller than that of the gold-coated mirror.

  9. Robust phase retrieval for high resolution edge illumination x-ray phase-contrast computed tomography in non-ideal environments

    Science.gov (United States)

    Zamir, Anna; Endrizzi, Marco; Hagen, Charlotte K.; Vittoria, Fabio A.; Urbani, Luca; De Coppi, Paolo; Olivo, Alessandro

    2016-01-01

    Edge illumination x-ray phase contrast tomography is a recently developed imaging technique which enables three-dimensional visualisation of low-absorbing materials. Dedicated phase retrieval algorithms can provide separate computed tomography (CT) maps of sample absorption, refraction and scattering properties. In this paper we propose a novel “modified local retrieval” method which is capable of accurately retrieving sample properties in a range of realistic, non-ideal imaging environments. These include system misalignment, defects in the used optical elements and system geometry variations over time due to vibrations or temperature fluctuations. System instabilities were analysed, modelled and incorporated into a simulation study. As a result, an additional modification was introduced to the retrieval procedure to account for changes in the imaging system over time, as well as local variations over the field of view. The performance of the proposed method was evaluated in comparison to a previously used “global retrieval” method by applying both approaches to experimental CT data of a rat’s heart acquired in a non-ideal environment. The use of the proposed method resulted in the removal of major artefacts, leading to a significant improvement in image quality. This method will therefore enable acquiring high-resolution, reliable CT data of large samples in realistic settings. PMID:27502296

  10. Localisation for industrial development

    CSIR Research Space (South Africa)

    Bhugwandin, Ashley

    2017-10-01

    Full Text Available Development Plan New Growth Plan Presidential Infrastructure Coordinating Commission Designation Industrial Policy Action Plan Technology Localisation Programme 4 Current situation • Majority of South African suppliers are importers with a....pdf.txt Content-Type text/plain; charset=UTF-8 1 Localisation for industrial development 05 October 2017 Ashley Bhugwandin, CSIR 2 Context • Commitment from government to support localisation and move it forward • Government has a responsibility...

  11. On ideals and idealization.

    Science.gov (United States)

    Morrison, Andrew P

    2009-04-01

    This chapter repositions ideals away from their role as defensive structures restraining aggressive and lustful drives (as traditionally viewed) toward their place in shaping creativity and love. We select and mold our particular ideals in providing meaning and in this manner help to create those selfobjects needed to resolve or soothe our needs. This creative process may include "reshaping" of the available object to represent the "idealized other." From this perspective, Kohut's view of idealization and the idealized parental imago will be considered, including my own notion of a one-and-a-half person psychology. Our ideals inevitably conflict and clash, leading to internal self-conflicts that generate what I call the dialectic of narcissism. Narcissism is here considered broadly, reflecting all attributes of self-experience. Shame plays an important role in this dialectic, relating to failure with regard to ideals and to falling short of cherished goals. Ultimately, it is the shaping of, and approximation to, flexible and meaningful ideals that comprise that lofty, ineffable, human ideal--wisdom. Clinical vignettes will be offered to illustrate these themes.

  12. AUTOMATIC LICENSE PLATE LOCALISATION AND IDENTIFICATION VIA SIGNATURE ANALYSIS

    Directory of Open Access Journals (Sweden)

    Lorita Angeline

    2014-02-01

    Full Text Available A new algorithm for license plate localisation and identification is proposed on the basis of Signature analysis. Signature analysis has been used to locate license plate candidate and its properties can be further utilised in supporting and affirming the license plate character recognition. This paper presents Signature Analysis and the improved conventional Connected Component Analysis (CCA to design an automatic license plate localisation and identification. A procedure called Euclidean Distance Transform is added to the conventional CCA in order to tackle the multiple bounding boxes that occurred. The developed algorithm, SAICCA achieved 92% successful rate, with 8% failed localisation rate due to the restrictions such as insufficient light level, clarity and license plate perceptual information. The processing time for a license plate localisation and recognition is a crucial criterion that needs to be concerned. Therefore, this paper has utilised several approaches to decrease the processing time to an optimal value. The results obtained show that the proposed system is capable to be implemented in both ideal and non-ideal environments.

  13. Monomial ideals, computations and applications

    CERN Document Server

    Gimenez, Philippe; Sáenz-de-Cabezón, Eduardo

    2013-01-01

    This work covers three important aspects of monomials ideals in the three chapters "Stanley decompositions" by Jürgen Herzog, "Edge ideals" by Adam Van Tuyl and "Local cohomology" by Josep Álvarez Montaner. The chapters, written by top experts, include computer tutorials that emphasize the computational aspects of the respective areas. Monomial ideals and algebras are, in a sense, among the simplest structures in commutative algebra and the main objects of combinatorial commutative algebra. Also, they are of major importance for at least three reasons. Firstly, Gröbner basis theory allows us to treat certain problems on general polynomial ideals by means of monomial ideals. Secondly, the combinatorial structure of monomial ideals connects them to other combinatorial structures and allows us to solve problems on both sides of this correspondence using the techniques of each of the respective areas. And thirdly, the combinatorial nature of monomial ideals also makes them particularly well suited to the devel...

  14. Antiphospholipid antibody in localised scleroderma

    OpenAIRE

    Sato, S.; Fujimoto, M; Hasegawa, M.; Takehara, K.

    2003-01-01

    Methods: Antibodies against cardiolipin (aCL) or ß2-glycoprotein I were examined by enzyme linked immunosorbent assay (ELISA) in 48 patients with localised scleroderma (18 patients with generalised morphoea, 20 with linear scleroderma, and 10 with morphoea). Twenty one of these patients were investigated for lupus anticoagulant (LAC) by screening and confirmatory coagulation tests.

  15. Antiphospholipid antibody in localised scleroderma.

    Science.gov (United States)

    Sato, S; Fujimoto, M; Hasegawa, M; Takehara, K

    2003-08-01

    To investigate the prevalence and clinical correlation of antiphospholipid antibodies in localised scleroderma. Antibodies against cardiolipin (aCL) or beta(2)-glycoprotein I were examined by enzyme linked immunosorbent assay (ELISA) in 48 patients with localised scleroderma (18 patients with generalised morphoea, 20 with linear scleroderma, and 10 with morphoea). Twenty one of these patients were investigated for lupus anticoagulant (LAC) by screening and confirmatory coagulation tests. Patients with generalised morphoea, the severest form of localised scleroderma, had significantly raised levels of IgM or IgG aCL relative to normal controls (n=21) and patients with systemic sclerosis (n=20). The IgM isotype was predominant, with the frequency of IgM aCL (61%) higher than that of IgG aCL (28%). Levels of aCL were similar for patients with linear scleroderma or morphoea and normal controls. IgM aCL were associated with a greater number of lesions, especially plaque lesions, wider distribution of lesions, and the presence of immunological abnormalities including antinuclear antibodies, rheumatoid factor, IgM antihistone antibodies, IgG anti-single stranded DNA antibodies, and raised serum interleukin 6 levels in patients with localised scleroderma. LAC was detected in 5/7 (71%) patients with generalised morphoea. However, pulmonary embolism was seen in only one patient with generalised morphoea. None of patients with localised scleroderma exhibited anti-beta(2)-glycoprotein I antibodies. These results suggest that aCL and LAC are the major autoantibodies in patients with generalised morphoea.

  16. Censorship and Digital Games Localisation in China

    National Research Council Canada - National Science Library

    Zhang, Xiaochun

    2012-01-01

    .... Although much of the research has focused on the interrelationship between these two areas, censorship systems and their influence on audiovisual translation, especially digital games localisation...

  17. Sex education and ideals

    NARCIS (Netherlands)

    de Ruyter, D.J.; Spiecker, B.

    2008-01-01

    This article argues that sex education should include sexual ideals. Sexual ideals are divided into sexual ideals in the strict sense and sexual ideals in the broad sense. It is argued that ideals that refer to the context that is deemed to be most ideal for the gratification of sexual ideals in the

  18. Sex Education and Ideals

    Science.gov (United States)

    de Ruyter, Doret J.; Spiecker, Ben

    2008-01-01

    This article argues that sex education should include sexual ideals. Sexual ideals are divided into sexual ideals in the strict sense and sexual ideals in the broad sense. It is argued that ideals that refer to the context that is deemed to be most ideal for the gratification of sexual ideals in the strict sense are rightfully called sexual…

  19. Multimodal Localisation: Analysis, Algorithms and Experimental Evaluation

    NARCIS (Netherlands)

    Kavitha Muthukrishnan, K.

    2009-01-01

    The term localisation is derived from the word locale, which traditionally means a small area or vicinity. In ancient days, localisation meant navigation -- an art of finding the way from one place to another. Tremendous advancement in the science of navigation dates back to the sixteenth century,

  20. Measuring Localisation Regionally to Form a Bhutanese Index

    Directory of Open Access Journals (Sweden)

    Michelle M. Olivier

    2016-07-01

    Full Text Available Localisation may be used as a strategy to remedy the harmful socio-ecological impacts of economic globalisation, and lead to improved sustainability achievements. This article describes the formation of a regional-level localisation index for the 20 districts of Bhutan, demonstrating a way to identify localised places using regionally specific data. Secondary source data were gathered in Bhutan according to localisation expert-identified metrics, which were then weighted, standardised, scored and ranked. This enabled the formation of a Bhutanese regional-level localisation index. The index may assist those seeking regional-level localisation case studies by enabling the identification of localised places in Bhutan. The article also summarises sustainability-planning interviews carried out across Bhutan to determine causal factors relating to localisation scores, in particular focusing on the top localisation-scoring district, Dagana. The interviews revealed that Bhutan is a highly localised country that has long and intentionally planned many aspects of localisation.

  1. Mobile price comparison application using localisation techniques

    OpenAIRE

    Dingli, Alexiei; Seychell, Dylan; 3rd International Conference on Web Science (ACM WebSci'11)

    2011-01-01

    In this paper we are proposing an Android mobile application. The main idea behind this system is to make use of localisation techniques together with information extraction techniques in order to develop a localised mobile price comparison application. This system extracts information from the web given a particular location and a source and provides price-comparison information to the end user on the mobile device. This paper briefly shows the background, methodology and evaluation of this ...

  2. Det asketiske ideal

    DEFF Research Database (Denmark)

    Albinus, Lars

    2016-01-01

    Nietzsches og Foucaults fremstilling af vestens asketiske ideal i religion, videnskab og filosofi......Nietzsches og Foucaults fremstilling af vestens asketiske ideal i religion, videnskab og filosofi...

  3. Pattern Formation on Networks: from Localised Activity to Turing Patterns

    Science.gov (United States)

    McCullen, Nick; Wagenknecht, Thomas

    2016-06-01

    Networks of interactions between competing species are used to model many complex systems, such as in genetics, evolutionary biology or sociology and knowledge of the patterns of activity they can exhibit is important for understanding their behaviour. The emergence of patterns on complex networks with reaction-diffusion dynamics is studied here, where node dynamics interact via diffusion via the network edges. Through the application of a generalisation of dynamical systems analysis this work reveals a fundamental connection between small-scale modes of activity on networks and localised pattern formation seen throughout science, such as solitons, breathers and localised buckling. The connection between solutions with a single and small numbers of activated nodes and the fully developed system-scale patterns are investigated computationally using numerical continuation methods. These techniques are also used to help reveal a much larger portion of of the full number of solutions that exist in the system at different parameter values. The importance of network structure is also highlighted, with a key role being played by nodes with a certain so-called optimal degree, on which the interaction between the reaction kinetics and the network structure organise the behaviour of the system.

  4. A Localised Corrosion Cell for Industrial Applications

    DEFF Research Database (Denmark)

    Andersen, A.; Hilbert, Lisbeth Rischel; Jansen, P.

    2003-01-01

    The LOCORR-CELL™ developed by FORCE TECHNOLOGY is an electrochemical cell for industrial applications estimating localised corrosion. The cell is constructed in a carbon steel casing for direct mounting into the system. It is based on an oxygen concentration element reflecting the interaction...... between the environment formed under a deposit or in a crevice. The essential feature of the method is that it reflects the influence of oxygen content, conductivity and temperature as well as the influence of corrosion inhibitors, MIC and other effects that have an effect on localised corrosion under...

  5. Comparing mobile robot localisation algorithms using Kalmtool

    DEFF Research Database (Denmark)

    Mogensen, Lars Valdemar; Hansen, Søren; Ravn, Ole

    2009-01-01

    In this paper we present an estimation platform with simulation capabilities to evaluate methods for localisation of a mobile robot using a feature map. The platform is based on the Kalmtool 4 toolbox which is a set of MATLAB tools for state estimation of nonlinear systems. The toolbox contains...

  6. Internationalisation, Localisation and Customisation Aspects of the ...

    African Journals Online (AJOL)

    TshwaneLex is the world's only lexicography software suite with which the entire lexicographic process, from initial compilation all the way to final product, may be conducted in the language of one's choice. This is possible thanks to various aspects of internationalisation, localisation and customisation that are built into ...

  7. Search and localisation of CERN buildings

    CERN Document Server

    TS/FM - Patrimony and Site Information Section

    2005-01-01

    A new, updated version of the web application allowing search and localisation of CERN buildings has been available since 20 May 2005. You can now find a specific building, road, car-park and other information regarding the CERN sites. For comments or enquiries please contact SIG.Support@cern.ch TS/FM - Patrimony and Site Information Section (ISP)

  8. Primary localised cutaneous amyloidosis - a systematic review

    DEFF Research Database (Denmark)

    Kaltoft, Britta; Schmidt, Grethe; Lauritzen, Anne Falensteen

    2013-01-01

    Amyloidosis is defined as extracellular deposits of heterogenic, misfolded proteins, amyloid fibrils, in various tissues. The aim of our study was to review the literature and to evaluate the risk of developing systemic amyloidosis (SA) and the risk of local recurrence of primary localised...

  9. Neuronal NOS localises to human airway cilia.

    Science.gov (United States)

    Jackson, Claire L; Lucas, Jane S; Walker, Woolf T; Owen, Holly; Premadeva, Irnthu; Lackie, Peter M

    2015-01-30

    Airway NO synthase (NOS) isoenzymes are responsible for rapid and localised nitric oxide (NO) production and are expressed in airway epithelium. We sought to determine the localisation of neuronal NOS (nNOS) in airway epithelium due to the paucity of evidence. Sections of healthy human bronchial tissue in glycol methacrylate resin and human nasal polyps in paraffin wax were immunohistochemically labelled and reproducibly demonstrated nNOS immunoreactivity, particularly at the proximal portion of cilia; this immunoreactivity was blocked by a specific nNOS peptide fragment. Healthy human epithelial cells differentiated at an air-liquid interface (ALI) confirmed the presence of all three NOS isoenzymes by immunofluorescence labelling. Only nNOS immunoreactivity was specific to the ciliary axonemeand co-localised with the cilia marker β-tubulin in the proximal part of the ciliary axoneme. We report a novel localisation of nNOS at the proximal portion of cilia in airway epithelium and conclude that its independent and local regulation of NO levels is crucial for normal cilia function. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. SCANNING KELVIN PROBE APPLIED TO LOCALISED ...

    African Journals Online (AJOL)

    2015-01-15

    Jan 15, 2015 ... SCANNING KELVIN PROBE APPLIED TO LOCALISED CORROSION. A. Hussain and Sk M. Haque. Department of Chemical Engineering and Process Technology, Jubail Industrial College,. P. O. Box. 10099, Al-Jubail, KSA. Received: 19 October 2014 / Accepted: 12 January 2015 / Published online: 15 ...

  11. Domains involved in TAF15 subcellular localisation

    DEFF Research Database (Denmark)

    Marko, Marija; Vlassis, Arsenios; Guialis, Apostolia

    2012-01-01

    to play important roles in the onset of specific tumours, certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). In this study we identified the domains of TAF15 responsible for its subcellular localisation in human (HeLa) cells and experimentally confirmed...

  12. Geographical localisation of the geomagnetic secular variation

    DEFF Research Database (Denmark)

    Aubert, Julien; Finlay, Chris; Olsen, Nils

    2013-01-01

    Directly observed changes in Earth’s magnetic field occur most prominently at low latitudes beneath the Atlantic hemisphere, while the Pacific is comparatively quiet. This striking hemispheric asymmetry in geomagnetic secular variation is a consequence of the geographical localisation of intense...

  13. xANTHOMATOSE NORMOLIPIDEMIQUE A LOCALISATION ...

    African Journals Online (AJOL)

    normolipidémiques. On distingue par ailleurs, les xantho- matoses secondaires et les xanthogranulomes juvéniles. dans tous les cas, les manifestations cliniques sont habi- tuellement cutanées (1). Ce cas clinique se singularise par la localisation endonasale en apparence exclusive chez une adolescente. OBSERVATION.

  14. Localisation nasosinusienne des tumeurs plasmocytaires | Kallel ...

    African Journals Online (AJOL)

    Localisation nasosinusienne des tumeurs plasmocytaires. S Kallel, A Chakroun, H Hadj Taieb, H Mnif, I Charfeddine, M Mnejja, B Hammami, A Ghorbel. Abstract. Introduction : Les tumeurs plasmocytaires représentent 3 à 4% des tumeurs des cavités naso-sinusiennes. Elles nécessitent un bilan diagnostique spécifique et ...

  15. An incremental approach to automated protein localisation

    Directory of Open Access Journals (Sweden)

    Kummert Franz

    2008-10-01

    Full Text Available Abstract Background The subcellular localisation of proteins in intact living cells is an important means for gaining information about protein functions. Even dynamic processes can be captured, which can barely be predicted based on amino acid sequences. Besides increasing our knowledge about intracellular processes, this information facilitates the development of innovative therapies and new diagnostic methods. In order to perform such a localisation, the proteins under analysis are usually fused with a fluorescent protein. So, they can be observed by means of a fluorescence microscope and analysed. In recent years, several automated methods have been proposed for performing such analyses. Here, two different types of approaches can be distinguished: techniques which enable the recognition of a fixed set of protein locations and methods that identify new ones. To our knowledge, a combination of both approaches – i.e. a technique, which enables supervised learning using a known set of protein locations and is able to identify and incorporate new protein locations afterwards – has not been presented yet. Furthermore, associated problems, e.g. the recognition of cells to be analysed, have usually been neglected. Results We introduce a novel approach to automated protein localisation in living cells. In contrast to well-known techniques, the protein localisation technique presented in this article aims at combining the two types of approaches described above: After an automatic identification of unknown protein locations, a potential user is enabled to incorporate them into the pre-trained system. An incremental neural network allows the classification of a fixed set of protein location as well as the detection, clustering and incorporation of additional patterns that occur during an experiment. Here, the proposed technique achieves promising results with respect to both tasks. In addition, the protein localisation procedure has been adapted

  16. Epidemiological Differences Between Localised and Non-Localised Low Back Pain

    Science.gov (United States)

    Coggon, David; Ntani, Georgia; Walker-Bone, Karen; Palmer, Keith T; Felli, Vanda E; Harari, Raul; Barrero, Lope H; Felknor, Sarah A.; Gimeno, David; Cattrell, Anna; Vargas-Prada, Sergio; Bonzini, Matteo; Solidaki, Eleni; Merisalu, Eda; Habib, Rima R.; Sadeghian, Farideh; Kadir, M Masood; Warnakulasuriya, Sudath SP; Matsudaira, Ko; Nyantumbu, Busisiwe; Sim, Malcolm R; Harcombe, Helen; Cox, Ken; Sarquis, Leila M M; Marziale, Maria H; Harari, Florencia; Freire, Rocio; Harari, Natalia; Monroy, Magda V; Quintana, Leonardo A; Rojas, Marianela; Harris, E Clare; Serra, Consol; Martinez, J Miguel; Delclos, George; Benavides, Fernando G; Carugno, Michele; Ferrario, Marco M; Pesatori, Angela C; Chatzi, Leda; Bitsios, Panos; Kogevinas, Manolis; Oha, Kristel; Freimann, Tiina; Sadeghian, Ali; Peiris-John, Roshini J; Sathiakumar, Nalini; Wickremasinghe, A Rajitha; Yoshimura, Noriko; Kelsall, Helen L; Hoe, Victor C W; Urquhart, Donna M; Derrett, Sarah; McBride, David; Herbison, Peter; Gray, Andrew; Salazar Vega, Eduardo J.

    2017-01-01

    Study design Cross-sectional survey with longitudinal follow-up Objectives To test the hypothesis that pain which is localised to the low back differs epidemiologically from that which occurs simultaneously or close in time to pain at other anatomical sites Summary of background data Low back pain (LBP) often occurs in combination with other regional pain, with which it shares similar psychological and psychosocial risk factors. However, few previous epidemiological studies of LBP have distinguished pain that is confined to the low back from that which occurs as part of a wider distribution of pain. Methods We analysed data from a cohort study of musculoskeletal pain and associated disability in 47 occupational groups from 18 countries. Results Among 12,197 subjects at baseline, 609 (4.9%) reported localised LBP in the past month, and 3,820 (31.3%) non-localised LBP. Non-localised LBP was more frequently associated with sciatica in the past month (48.1% vs. 30.0% of cases), occurred on more days in the past month and past year, was more often disabling for everyday activities (64.1% vs. 47.3% of cases), and had more frequently led to medical consultation and sickness absence from work. It was also more often persistent when participants were followed up after a mean of 14 months (65.6% vs. 54.1% of cases). In adjusted Poisson regression analyses, non-localised LBP was differentially associated with female sex, older age, somatising tendency, poor mental health and report of time pressure at work,. There were also marked differences in the relative prevalence of localised and non-localised LBP by occupational group. Conclusions Future epidemiological studies should distinguish where possible between pain that is limited to the low back and LBP which occurs in association with pain at other anatomical locations. PMID:27820794

  17. Optical sensing with Anderson-localised light

    Science.gov (United States)

    Trojak, Oliver Joe; Crane, Tom; Sapienza, Luca

    2017-10-01

    We show that fabrication imperfections in silicon nitride photonic crystal waveguides can be used as a resource to efficiently confine light in the Anderson-localised regime and add functionalities to photonic devices. Our results prove that disorder-induced localisation of light can be utilised to realise an alternative class of high-quality optical sensors operating at room temperature. We measure wavelength shifts of optical resonances as large as 15.2 nm, more than 100 times the spectral linewidth of 0.15 nm, for a refractive index change of about 0.38. By studying the temperature dependence of the optical properties of the system, we report wavelength shifts of up to about 2 nm and increases of more than a factor 2 in the quality factor of the cavity resonances, when going from room to cryogenic temperatures. Such a device can allow simultaneous sensing of both local contaminants and temperature variations, monitored by tens of optical resonances spontaneously appearing along a single photonic crystal waveguide. Our findings demonstrate the potential of Anderson-localised light in photonic crystals for scalable and efficient optical sensors operating in the visible and near-infrared range of wavelengths.

  18. Edge Bioinformatics

    Energy Technology Data Exchange (ETDEWEB)

    2015-08-03

    Edge Bioinformatics is a developmental bioinformatics and data management platform which seeks to supply laboratories with bioinformatics pipelines for analyzing data associated with common samples case goals. Edge Bioinformatics enables sequencing as a solution and forward-deployed situations where human-resources, space, bandwidth, and time are limited. The Edge bioinformatics pipeline was designed based on following USE CASES and specific to illumina sequencing reads. 1. Assay performance adjudication (PCR): Analysis of an existing PCR assay in a genomic context, and automated design of a new assay to resolve conflicting results; 2. Clinical presentation with extreme symptoms: Characterization of a known pathogen or co-infection with a. Novel emerging disease outbreak or b. Environmental surveillance

  19. Forum; Het ideale vrijetijdslandschap

    NARCIS (Netherlands)

    Peters, K.B.M.; Embregts, M.

    2009-01-01

    Het Kenniscentrum Recreatie is in 2009 gestart met een debat getiteld 'Het ideale vrijetijdslandschap'. Doel van dit debat is inzicht te krijgen in zowel de wensen als de realisatie van het ideale Nederlandse vrijetijdslandschap. In dit Forum wordt aandacht besteedt aan dit debat. De eerste bijdrage

  20. Socrates: Platonic Political Ideal

    National Research Council Canada - National Science Library

    Christopher Long

    2012-01-01

    .... In the Phaedo, this ideal of a Socrates is amplified in such a way that Platonic writing itself emerges as capable of doing with readers what Socratic speaking did with those he encountered. Socrates is the Platonic political ideal. The result is a picture of the transformative political power of Socratic speaking and Platonic writing both.

  1. Ideal Theory and Utopia

    NARCIS (Netherlands)

    V. Ruitinga (Volker)

    2011-01-01

    textabstractJohn Rawls presents his work on social justice as Ideal Theory. By taking an idealized scenario, he is able to consider the compatibility of different concepts relating to social justice without being hampered by all the complexities of society and its actors; an approach to social

  2. The propagation of detonation waves in non-ideal condensed-phase explosives confined by high sound-speed materials

    Science.gov (United States)

    Schoch, Stefan; Nikiforakis, Nikolaos; Lee, Bok Jik

    2013-08-01

    Highly non-ideal condensed-phase explosives used by the mining industry have a strong detonation velocity dependence on the charge dimension. Detonation velocities can be as low as one third of the theoretically calculated ideal detonation velocity in charge radii close to the failure radius. Under these detonation conditions the flow in the confiner can become subsonic, a flow condition under which classical shock-polar analysis is not applicable. This restriction prohibits the use of popular engineering models like detonation shock dynamics and Wood-Kirkwood type models under these confinement conditions. In addition, it has been found in the literature that subsonic flow in the confiner will increase the influence of the confining material on the detonation performance. In this work, we use a multi-phase model coupled to an elastic-plastic model (for the representation of a confiner) to explore the interaction of detonations under these confiner conditions. An ammonium nitrate based mining emulsion is investigated in aluminium and steel confinement of finite and infinite thickness representing the confiner as either a fluid or an elastic-plastic material. It is found that the presence of elastic waves is negligible close to ideal detonation conditions, but is important close to the failure radius and in detonation conditions with subsonic flow in the confiner. High sound-speed confiners support the detonation through energy transport ahead of the detonation front if desensitisation effects are negligible. The detonation front profiles are found to remain convex even in the most non-ideal detonation conditions, and the detonation front curvature only becomes concave in a localised region close to the confiner edge.

  3. German Idealism Today

    DEFF Research Database (Denmark)

    Rasmussen, Anders Moe; Gabriel, Markus

    This collection of essays provides an exemplary overwiew of the diversity and relevance of current scholarship on German Idealism. The importance of German Idealism for contemporary philosophy has recieved growing attention and acknowledgment throughout competing fields of contemporary philosophy....... Part of the growing interest rests on the claim that the works of Kant, Fichte, Schelling, Hegel remain of considerable interest for cultural studies, sociology, theology aesthetics and other ereas. In the domain of philosophy, the renaissance of innovative readings of German Idealism has taken...

  4. The Idealized Cultural Encounter

    DEFF Research Database (Denmark)

    Christiansen, Lene Bull

    ). This paper proposes to study cultural encounters which are organised around ideals of cultural difference as a positive social and political force. The Danish People to People NGO Mellemfolkeligt Samvirke (MS) is build around ideals of equality, co-operation, mutuality and solidarity between people...... framework for an investigation into MS’ organisation of what I have termed ‘the idealized cultural encounter’, while also questioning the ways in which ‘culture’ is envisioned in contexts where ‘encounter’ is seen as a positive and desirable force....

  5. Human V6: functional characterisation and localisation.

    Directory of Open Access Journals (Sweden)

    Velia Cardin

    Full Text Available Human visual area V6, in the parieto-occipital sulcus, is thought to have an important role in the extraction of optic flow for the monitoring and guidance of self-motion (egomotion because it responds differentially to egomotion-compatible optic flow when compared to: (a coherent but egomotion-incompatible flow (Cardin & Smith, 2010, and (b incoherent motion (Pitzalis et al., 2010. It is not clear, however, whether V6 responds more strongly to egomotion-incompatible global motion than to incoherent motion. This is relevant not only for determining the functional properties of V6, but also in order to choose optimal stimuli for localising V6 accurately with fMRI. Localisation with retinotopic mapping is difficult and there is a need for a simple, reliable method. We conducted an event-related 3T fMRI experiment in which participants viewed a display of dots which either: a followed a time-varying optic flow trajectory in a single, egomotion-compatible (EC display; b formed an egomotion-incompatible (EI 3 × 3 array of optic flow patches; or c moved randomly (RM. Results from V6 show an ordering of response magnitudes: EC > EI > RM. Neighbouring areas V3A and V7 responded more strongly to EC than to RM, but about equally to EC and EI. Our results suggest that although V6 may have a general role in the extraction of global motion, in clear contrast to neighbouring motion areas it is especially concerned with encoding EC stimuli. They suggest two strategies for localising V6: (1 contrasting EC and EI; or (2 contrasting EC and RM, which is more sensitive but carries a risk of including voxels from neighbouring regions that also show a EC > RM preference.

  6. Human V6: functional characterisation and localisation.

    Science.gov (United States)

    Cardin, Velia; Sherrington, Rachael; Hemsworth, Lara; Smith, Andrew T

    2012-01-01

    Human visual area V6, in the parieto-occipital sulcus, is thought to have an important role in the extraction of optic flow for the monitoring and guidance of self-motion (egomotion) because it responds differentially to egomotion-compatible optic flow when compared to: (a) coherent but egomotion-incompatible flow (Cardin & Smith, 2010), and (b) incoherent motion (Pitzalis et al., 2010). It is not clear, however, whether V6 responds more strongly to egomotion-incompatible global motion than to incoherent motion. This is relevant not only for determining the functional properties of V6, but also in order to choose optimal stimuli for localising V6 accurately with fMRI. Localisation with retinotopic mapping is difficult and there is a need for a simple, reliable method. We conducted an event-related 3T fMRI experiment in which participants viewed a display of dots which either: a) followed a time-varying optic flow trajectory in a single, egomotion-compatible (EC) display; b) formed an egomotion-incompatible (EI) 3 × 3 array of optic flow patches; or c) moved randomly (RM). Results from V6 show an ordering of response magnitudes: EC > EI > RM. Neighbouring areas V3A and V7 responded more strongly to EC than to RM, but about equally to EC and EI. Our results suggest that although V6 may have a general role in the extraction of global motion, in clear contrast to neighbouring motion areas it is especially concerned with encoding EC stimuli. They suggest two strategies for localising V6: (1) contrasting EC and EI; or (2) contrasting EC and RM, which is more sensitive but carries a risk of including voxels from neighbouring regions that also show a EC > RM preference.

  7. On Classical Ideal Gases

    National Research Council Canada - National Science Library

    Jacques Arnaud; Laurent Chusseau; Fabrice Philippe

    2013-01-01

      We show that the thermodynamics of ideal gases may be derived solely from the Democritean concept of corpuscles moving in vacuum plus a principle of simplicity, namely that these laws are independent...

  8. New Struggles, Old Ideals

    DEFF Research Database (Denmark)

    Thomsen, Line Hassall

    ITV. En unik adgang til redaktioner, redaktionsmøder og journalisters daglige arbejdsgang giver et nyt indblik i journalistisk praksis i dag. Afhandlingen udfolder et spændingsfelt mellem journalisternes professionsidealer og de produktionsvilkår, de er underlagt. Denne forskel mellem ideal og...... realitet udforskes og analyseres som en konstant spænding mellem nye udfordringer og gamle, journalistiske idealer....

  9. Developmental Idealism in China.

    Science.gov (United States)

    Thornton, Arland; Xie, Yu

    2016-10-01

    This paper examines the intersection of developmental idealism with China. It discusses how developmental idealism has been widely disseminated within China and has had enormous effects on public policy and programs, on social institutions, and on the lives of individuals and their families. This dissemination of developmental idealism to China began in the 19th century, when China met with several military defeats that led many in the country to question the place of China in the world. By the beginning of the 20th century, substantial numbers of Chinese had reacted to the country's defeats by exploring developmental idealism as a route to independence, international respect, and prosperity. Then, with important but brief aberrations, the country began to implement many of the elements of developmental idealism, a movement that became especially important following the assumption of power by the Communist Party of China in 1949. This movement has played a substantial role in politics, in the economy, and in family life. The beliefs and values of developmental idealism have also been directly disseminated to the grassroots in China, where substantial majorities of Chinese citizens have assimilated them. These ideas are both known and endorsed by very large numbers in China today.

  10. To localise or to be localised with Wifi in the Hubei museum?

    NARCIS (Netherlands)

    Verbree, E.; Zlatanova, S.; Van Winden, K.; Van der Laan, E.B.; Makri, A.; Taizhou, L.; Haojun, A.

    2013-01-01

    Indoor localisation is in demand for a variety of applications within the built environment. An overall solution based on a single technology has not yet been determined. The aim of this paper is to gain insight on Signal Strength monitoring by a special kind of WiFi Monitors in comparison to the

  11. Scale-dependent background-error covariance localisation

    Directory of Open Access Journals (Sweden)

    Mark Buehner

    2015-12-01

    Full Text Available A new approach is presented and evaluated for efficiently applying scale-dependent spatial localisation to ensemble background-error covariances within an ensemble-variational data assimilation system. The approach is primarily motivated by the requirements of future data assimilation systems for global numerical weather prediction that will be capable of resolving the convective scale. Such systems must estimate the global and synoptic scales at least as well as current global systems while also effectively making use of information from frequent and spatially dense observation networks to constrain convective-scale features. Scale-dependent covariance localisation allows a wider range of scales to be efficiently estimated while simultaneously assimilating all available observations. In the context of an idealised numerical experiment, it is shown that using scale-dependent localisation produces an improved ensemble-based estimate of spatially varying covariances as compared with standard spatial localisation. When applied to an ensemble of Arctic sea-ice concentration, it is demonstrated that strong spatial gradients in the relative contribution of different spatial scales in the ensemble covariances result in strong spatial variations in the overall amount of spatial localisation. This feature is qualitatively similar to what might be expected when applying an adaptive localisation approach that estimates a spatially varying localisation function from the ensemble itself. When compared with standard spatial localisation, scale-dependent localisation also results in a lower analysis error for sea-ice concentration over all spatial scales.

  12. Evolution of sound localisation in land vertebrates.

    Science.gov (United States)

    Köppl, Christine

    2009-08-11

    The story of the evolution of hearing in land vertebrates is fascinating but complex. The water-to-land transition changed the physical environment in which hearing happens so dramatically that both the peripheral receptor structures and the central auditory circuits underwent a revolution, leading to the sensitive hearing of higher-frequency airborne sound. This (r)evolution took a very long time indeed. Most of it happened after the early divergence of the major clades of land vertebrates. Hearing, at least hearing as we commonly understand it today, is the youngest of the major senses and much of its evolutionary history is not shared between amphibians, lepidosauromorphs (lizards and snakes), archosauromorphs (birds and crocodilians) and mammals. There was no linear evolution of complexity from 'lower' to 'higher' vertebrates. We are only just beginning to appreciate the implications of this for central auditory processing. There is no consensus, yet, on the evolution of sound localisation. The multitude of physical cues involved in sound localisation means that different selective pressures interact and need to be considered. The use and neural processing of interaural time differences is just one example. It has taught us that long-standing assumptions, such as the homology of the mammalian medial superior olive and the avian nucleus laminaris, need to be questioned and that important insights may arise from unexpected directions, such as the paleontology of middle-ear ossicles. There is still much to discover.

  13. Impact source localisation in aerospace composite structures

    Science.gov (United States)

    De Simone, Mario Emanuele; Ciampa, Francesco; Boccardi, Salvatore; Meo, Michele

    2017-12-01

    The most commonly encountered type of damage in aircraft composite structures is caused by low-velocity impacts due to foreign objects such as hail stones, tool drops and bird strikes. Often these events can cause severe internal material damage that is difficult to detect and may lead to a significant reduction of the structure’s strength and fatigue life. For this reason there is an urgent need to develop structural health monitoring systems able to localise low-velocity impacts in both metallic and composite components as they occur. This article proposes a novel monitoring system for impact localisation in aluminium and composite structures, which is able to determine the impact location in real-time without a-priori knowledge of the mechanical properties of the material. This method relies on an optimal configuration of receiving sensors, which allows linearization of well-known nonlinear systems of equations for the estimation of the impact location. The proposed algorithm is based on the time of arrival identification of the elastic waves generated by the impact source using the Akaike Information Criterion. The proposed approach was demonstrated successfully on both isotropic and orthotropic materials by using a network of closely spaced surface-bonded piezoelectric transducers. The results obtained show the validity of the proposed algorithm, since the impact sources were detected with a high level of accuracy. The proposed impact detection system overcomes current limitations of other methods and can be retrofitted easily on existing aerospace structures allowing timely detection of an impact event.

  14. Edge Detection,

    Science.gov (United States)

    1985-09-01

    PROJECT. T ASK0 Artificial Inteligence Laboratory AREA It WORK UNIT NUMBERS V 545 Technology Square ( Cambridge, HA 02139 I I* CONTOOL1LIN@4OFFICE NAME...ARD-A1t62 62 EDGE DETECTION(U) NASSACNUSETTS INST OF TECH CAMBRIDGE 1/1 ARTIFICIAL INTELLIGENCE LAB E C HILDRETH SEP 85 AI-M-8 N99SI4-8S-C-6595...used to carry out this analysis. cce~iO a N) ’.~" D LI’BL. P p ------------ Sj. t i MASSACHUSETTS INSTITUTE OF TECHNOLOGY i ARTIFICIAL INTELLIGENCE

  15. Socrates: Platonic Political Ideal

    Directory of Open Access Journals (Sweden)

    Christopher P. Long

    2012-08-01

    Full Text Available This essay articulates the differences and suggests the similarities between the practices of Socratic political speaking and those of Platonic political writing. The essay delineates Socratic speaking and Platonic writing as both erotically oriented toward ideals capable of transforming the lives of individuals and their relationships with one another. Besides it shows that in the Protagoras the practices of Socratic political speaking are concerned less with Protagoras than with the individual young man, Hippocrates. In the Phaedo, this ideal of a Socrates is amplified in such a way that Platonic writing itself emerges as capable of doing with readers what Socratic speaking did with those he encountered. Socrates is the Platonic political ideal. The result is a picture of the transformative political power of Socratic speaking and Platonic writing both.

  16. On Classical Ideal Gases

    Directory of Open Access Journals (Sweden)

    Laurent Chusseau

    2013-02-01

    Full Text Available We show that the thermodynamics of ideal gases may be derived solely from the Democritean concept of corpuscles moving in vacuum plus a principle of simplicity, namely that these laws are independent of the laws of motion, aside from the law of energy conservation. Only a single corpuscle in contact with a heat bath submitted to a z and t-invariant force is considered. Most of the end results are known but the method appears to be novel. The mathematics being elementary, the present paper should facilitate the understanding of the ideal gas law and of classical thermodynamics even though not-usually-taught concepts are being introduced.

  17. An innovative localisation algorithm for railway vehicles

    Science.gov (United States)

    Allotta, B.; D'Adamio, P.; Malvezzi, M.; Pugi, L.; Ridolfi, A.; Rindi, A.; Vettori, G.

    2014-11-01

    In modern railway automatic train protection and automatic train control systems, odometry is a safety relevant on-board subsystem which estimates the instantaneous speed and the travelled distance of the train; a high reliability of the odometry estimate is fundamental, since an error on the train position may lead to a potentially dangerous overestimation of the distance available for braking. To improve the odometry estimate accuracy, data fusion of different inputs coming from a redundant sensor layout may be used. The aim of this work has been developing an innovative localisation algorithm for railway vehicles able to enhance the performances, in terms of speed and position estimation accuracy, of the classical odometry algorithms, such as the Italian Sistema Controllo Marcia Treno (SCMT). The proposed strategy consists of a sensor fusion between the information coming from a tachometer and an Inertial Measurements Unit (IMU). The sensor outputs have been simulated through a 3D multibody model of a railway vehicle. The work has provided the development of a custom IMU, designed by ECM S.p.a, in order to meet their industrial and business requirements. The industrial requirements have to be compliant with the European Train Control System (ETCS) standards: the European Rail Traffic Management System (ERTMS), a project developed by the European Union to improve the interoperability among different countries, in particular as regards the train control and command systems, fixes some standard values for the odometric (ODO) performance, in terms of speed and travelled distance estimation. The reliability of the ODO estimation has to be taken into account basing on the allowed speed profiles. The results of the currently used ODO algorithms can be improved, especially in case of degraded adhesion conditions; it has been verified in the simulation environment that the results of the proposed localisation algorithm are always compliant with the ERTMS requirements

  18. Localisation system in wireless sensor networks using ns-2

    CSIR Research Space (South Africa)

    Abu-Mahfouz, Adnan M

    2012-04-01

    Full Text Available where the nodes will be distributed, which allows evaluating the localisation algorithm considering different nodes distribution. If you comparing different localisation algorithms the same value(s) of SEED should be used (except the value of 0..."; /*========================================================================= =================================================*/ /*========~ns/common/mobilenode.h========================================== =================================================*/ Add the following: inline Topography* get_topography() { return T_;} // log the location information void log_loc(double...

  19. Amelogenesis imperfecta and localised aggressive periodontitis: A rare clinical entity

    Directory of Open Access Journals (Sweden)

    Gayatri Gundannavar

    2013-01-01

    Full Text Available This case report presents two female patients whose chief complaint was discoloration of teeth. On careful clinical examination it was found that the patients had features of amelogenesis imperfecta and localised aggressive periodontitis. This article will give an insight of clinical and radiographic features of amelogenesis imperfecta with localised aggressive periodontitis, which is a rare clinical entity.

  20. Differences in finger localisation performance of patients with finger agnosia

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; de Haan, E.H.F.; Kappelle, L.J.; Leijten, F.S.; van Zandvoort, M.J.E.; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports

  1. Differences in finger localisation performance of patients with finger agnosia

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; Haan, E.H.F. de; Kappelle, L.J.; Leijten, F.S.S.; Zandvoort, M.J.E. van; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on ones own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports describe

  2. Differences in finger localisation performance of patients with finger agnosia.

    NARCIS (Netherlands)

    Anema, H.A.; Kessels, R.P.C.; Haan, E.H.F. de; Kappelle, L.J.; Leijten, F.S.S.; Zandvoort, M.J. Van; Dijkerman, H.C.

    2008-01-01

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports

  3. Feasibility of magnetic marker localisation for non-palpable breast cancer

    NARCIS (Netherlands)

    Schermers, B.; van der Hage, Jos A.; Loo, C.E.; Vrancken Peeters, M.T.F.D.; Winter-Warnars, H. A.O.; Duijnhoven, F.H.; ten Haken, B.; Muller, S.H.; Ruers, T. J.M.

    2017-01-01

    Objectives Accurate tumour localisation is essential for breast-conserving surgery of non-palpable tumours. Current localisation technologies are associated with disadvantages such as logistical challenges and migration issues (wire guided localisation) or legislative complexities and high

  4. Ideal Theory, Real Rationality

    DEFF Research Database (Denmark)

    Flyvbjerg, Bent

    as an example of a political philosopher who fails to recognize that actual political and administrative rationality lagely disrupts the relevance of his ideal prescriptopns. Michel Foucault proposed as an antidote to Habermas in a comparativestudy of the two. Machiavellian "verita effettuale" (effective truth...

  5. Reaction-Diffusion Automata Phenomenology, Localisations, Computation

    CERN Document Server

    Adamatzky, Andrew

    2013-01-01

    Reaction-diffusion and excitable media are amongst most intriguing substrates. Despite apparent simplicity of the physical processes involved the media exhibit a wide range of amazing patterns: from target and spiral waves to travelling localisations and stationary breathing patterns. These media are at the heart of most natural processes, including morphogenesis of living beings, geological formations, nervous and muscular activity, and socio-economic developments.   This book explores a minimalist paradigm of studying reaction-diffusion and excitable media using locally-connected networks of finite-state machines: cellular automata and automata on proximity graphs. Cellular automata are marvellous objects per se because they show us how to generate and manage complexity using very simple rules of dynamical transitions. When combined with the reaction-diffusion paradigm the cellular automata become an essential user-friendly tool for modelling natural systems and designing future and emergent computing arch...

  6. Living edge

    DEFF Research Database (Denmark)

    Earon, Ofri

    2014-01-01

    was originally introduced to enhance indoor qualities including light and view. Throughout the paper, it is argued that these ecological motives have grown to architectural and urban dimensions. The paper analyzes the characteristics and potentials of these dimensions and their interconnections. The paper...... on the ground level, but there is a lack of recognition in the significance of communicative characters as well at the higher part of the edge. The city’s planning approach is “Consider urban life before urban space. Consider urban space before buildings” This urban strategy neglects the possible architectural...... contribution to the street atmosphere and its effect on urban life. Bay balcony has been a common architectural element in Copenhagen’s residential buildings, since the end of the twenties. It is a domestic border with an architectural thickness combining window, door, windowsill and balcony. The bay balcony...

  7. Immunohistochemical localisation of TRA-1-60, TRA-1-81, GCTM-2 and podocalyxin in the developing baboon kidney.

    Science.gov (United States)

    Gubhaju, Lina; Laslett, Andrew; Bertram, John F; Zulli, Anthony; Black, M Jane

    2008-05-01

    The baboon is an ideal animal model to study human kidney development. The aim of the current study was to use immunohistochemistry to localise the antigens TRA-1-60, TRA-1-81, GCTM-2 and podocalyxin in the developing baboon kidney where nephrogenesis was still on-going and in kidneys where nephrogenesis was complete. Fixed kidney sections from baboons delivered at 125, 140, 175 and 185 days gestation (term = 185 days) were immuno-labelled with antibodies directed against TRA-1-60, TRA-1-81, GCTM-2 and podocalyxin. In kidneys with on-going nephrogenesis (125 and 140 days gestation), TRA-1-60, TRA-1-81 and GCTM-2 were specifically localised to the apical plasma membrane of the epithelium of the ureteric ampullae and the collecting ducts, while podocalyxin immunostaining was not detected. In kidneys where nephrogenesis was complete (175 and 185 days gestation) localisation of these markers was again very specifically localised to the collecting ducts. In conclusion, although further experimentation is required to confirm the identity of the specific cell types marked by these antibodies, this study provides new insight into the distribution of commonly utilised stem cell antibodies in the developing baboon kidney.

  8. Ideal evaluation from coevolution.

    Science.gov (United States)

    de Jong, Edwin D; Pollack, Jordan B

    2004-01-01

    In many problems of interest, performance can be evaluated using tests, such as examples in concept learning, test points in function approximation, and opponents in game-playing. Evaluation on all tests is often infeasible. Identification of an accurate evaluation or fitness function is a difficult problem in itself, and approximations are likely to introduce human biases into the search process. Coevolution evolves the set of tests used for evaluation, but has so far often led to inaccurate evaluation. We show that for any set of learners, a Complete Evaluation Set can be determined that provides ideal evaluation as specified by Evolutionary Multi-Objective Optimization. This provides a principled approach to evaluation in coevolution, and thereby brings automatic ideal evaluation within reach. The Complete Evaluation Set is of manageable size, and progress towards it can be accurately measured. Based on this observation, an algorithm named DELPHI is developed. The algorithm is tested on problems likely to permit progress on only a subset of the underlying objectives. Where all comparison methods result in overspecialization, the proposed method and a variant achieve sustained progress in all underlying objectives. These findings demonstrate that ideal evaluation may be approximated by practical algorithms, and that accurate evaluation for test-based problems is possible even when the underlying objectives of a problem are unknown. Copryright 2004 Massachusetts Institute of Technology

  9. Socrates: Platonic Political Ideal

    Directory of Open Access Journals (Sweden)

    Christopher P. Long

    2012-01-01

    Full Text Available El ensayo articula diferencias y sugiere similitudes entre las prácticas del diálogo político de Sócrates y aquellas de la escritura política de Platón. Propone, además, que tanto el diálogo socrático como la escritura platónica se orientan eróticamente hacia ideales capaces de transformar las vidas de los individuos y sus relaciones. Demuestra que en el Protágoras las prácticas del diálogo socrático se ocupan menos de Protágoras que del joven Hipócrates. En el Fedón, este ideal de Sócrates se amplía de tal manera que la misma escritura platónica aparece como capaz de hacer con los lectores lo que el diálogo de Sócrates hacía con sus interlocutores. Sócrates es el ideal político platónico. El resultado es una visión del poder de transformación política tanto del diálogo socrático como de la escritura platónica.

  10. Drosophila Syncrip binds the gurken mRNA localisation signal and regulates localised transcripts during axis specification

    Directory of Open Access Journals (Sweden)

    Suzanne M. McDermott

    2012-04-01

    In the Drosophila oocyte, mRNA transport and localised translation play a fundamental role in axis determination and germline formation of the future embryo. gurken mRNA encodes a secreted TGF-α signal that specifies dorsal structures, and is localised to the dorso-anterior corner of the oocyte via a cis-acting 64 nucleotide gurken localisation signal. Using GRNA chromatography, we characterised the biochemical composition of the ribonucleoprotein complexes that form around the gurken mRNA localisation signal in the oocyte. We identified a number of the factors already known to be involved in gurken localisation and translational regulation, such as Squid and Imp, in addition to a number of factors with known links to mRNA localisation, such as Me31B and Exu. We also identified previously uncharacterised Drosophila proteins, including the fly homologue of mammalian SYNCRIP/hnRNPQ, a component of RNA transport granules in the dendrites of mammalian hippocampal neurons. We show that Drosophila Syncrip binds specifically to gurken and oskar, but not bicoid transcripts. The loss-of-function and overexpression phenotypes of syncrip in Drosophila egg chambers show that the protein is required for correct grk and osk mRNA localisation and translational regulation. We conclude that Drosophila Syncrip is a new factor required for localisation and translational regulation of oskar and gurken mRNA in the oocyte. We propose that Syncrip/SYNCRIP is part of a conserved complex associated with localised transcripts and required for their correct translational regulation in flies and mammals.

  11. Monitoring based localisation of pollution sources

    Science.gov (United States)

    Sokac, M.; Velisková, Y.

    2017-10-01

    Water quality modelling is currently very effective and important tool in context of the task to ensure the required quality of water resources, respectively, to achieve (maintain) good water status according the Water Framework Directive (2000/60/EC). This paper analyses the current status in numerical modelling of pollution dispersion in streams and use of some modelling approaches for the inverse task. Inverse task means a modelling technique, which is focused on the localisation of unknown pollution source (typical common models or equations are rather focused on the pollution spreading simulation, whereas the pollution source location is known). Paper offers an idea of such inverse task solution. It is based on the known pollution concentration time courses or it can be based on the results of the on-line monitoring of the specific water quality parameters as well. For the application of inverse tasks in conditions of real streams and rivers a large number of various requirements and conditions in specific river should be considered, i. a. the non-prismatic river bed, occurrence of dead zones, dispersion rate etc. Paper also describes the first version of the software for solving inverse tasks and preliminary experiences of using this software.

  12. Ideal Magnetohydrodynamic Stability of the NCSX

    Energy Technology Data Exchange (ETDEWEB)

    Fu, GuoYong [Princeton Plasma Physics Laboratory (PPPL); Isaev, Maxim Yu [Kurchatov Institute, Moscow, Russia; Ku, Long-Poe [Princeton Plasma Physics Laboratory (PPPL); Mikhailov, M [Kurchatov Institute, Moscow, Russia; Redi, M H [Princeton Plasma Physics Laboratory (PPPL); Sanchez, Raul [ORNL; Subbotin, A [Kurchatov Institute, Moscow, Russia; Hirshman, Steven Paul [ORNL; Cooper, W Anthony [CRPP/EPFL, Association Euratom-Suisse, Lausanne, Switzerland; Monticello, D. [Princeton Plasma Physics Laboratory (PPPL); Reiman, A H [Princeton Plasma Physics Laboratory (PPPL); Zarnstorff, M. C. [Princeton Plasma Physics Laboratory (PPPL)

    2007-01-01

    The ideal magnetohydrodynamic (MHD) stability of the National Compact Stellarator Experiment (NCSX) is extensively analyzed using the most advanced three-dimensional MHD codes. It is shown that the NCSX is stable to finite-n MHD modes, including the vertical mode, external kink modes and ballooning modes. However, high-n external kink modes that peak near the plasma edge are found to be weakly unstable. A global calculation shows that finite-n ballooning modes are significantly more stable than the local infinite-n modes.

  13. Physics of Skiing: The Ideal-Carving Equation and Its Applications

    OpenAIRE

    Jentschura, U. D.; Fahrbach, F.

    2003-01-01

    Ideal carving occurs when a snowboarder or skier, equipped with a snowboard or carving skis, describes a perfect carved turn in which the edges of the ski alone, not the ski surface, describe the trajectory followed by the skier, without any slipping or skidding. In this article, we derive the "ideal-carving" equation which describes the physics of a carved turn under ideal conditions. The laws of Newtonian classical mechanics are applied. The parameters of the ideal-carving equation are the ...

  14. Generalised two target localisation using passive monopulse radar

    KAUST Repository

    Jardak, Seifallah

    2017-04-07

    The simultaneous lobing technique, also known as monopulse technique, has been widely used for fast target localisation and tracking purposes. Many works focused on accurately localising one or two targets lying within a narrow beam centred around the monopulse antenna boresight. In this study, a new approach is proposed, which uses the outputs of four antennas to rapidly localise two point targets present in the hemisphere. If both targets have the same elevation angle, the proposed scheme cannot detect them. To detect such targets, a second set of antennas is required. In this study, to detect two targets at generalised locations, the antenna array is divided into multiple overlapping sets each of four antennas. Two algorithms are proposed to combine the outputs from multiple sets and improve the detection performance. Simulation results show that the algorithm is able to localise both targets with <;2° mean square error in azimuth and elevation.

  15. Entrepreneurship in China: The role of localisation and urbanisation economies

    NARCIS (Netherlands)

    Guo, Qi; He, Canfei; Li, D.

    Why are some regions more entrepreneurial than others? This study explores the determinants of manufacturing entrepreneurship at the prefectural city level in China by highlighting the influence of localisation and urbanisation economies and the significance of technological relatedness and small

  16. The expirience of IDEAL

    Directory of Open Access Journals (Sweden)

    E. Z. Burnevich

    2010-01-01

    Full Text Available Combination therapy with pegylated interferon-α and ribavirin is the modern standard of chronic hepatitis C treatment [1-3] in Russian Federation [4]. This particular regimen provides achieving of sustained virological response (SVR in 42-28% of patient with genotype 1 chronic hepatitis C [5,6]. IDEAL (Individualized Dosing Efficacy vs. flat dosing to Assess optimaL pegylated interferon therapy study was designed to assess the most optimal and effective antiviral therapy regiment. IDEAL was randomized, in parallel groups, multicenter phase IIIb study to assess efficacy and safety of two combination regiment with pegylated interferon alfa-2b (dosing regimens: 1,5 and 1,0 mcg/kg/week and ribavirin, administered according to body weight (800–1400 mg/day compared with pegylated interferon alfa-2a 180 mcg/week in combination with ribavirin 1000–1200 mg/day in genotype 1 chronic hepatitis C patients.

  17. Capturing Medical Students’ Idealism

    Science.gov (United States)

    Smith, Janice K.; Weaver, Donna B.

    2006-01-01

    PURPOSE Students’ idealism and desire to work with underserved populations decline as they progress from preclinical training through clerkships and residency. With an increasingly diverse population and increasing health disparities, academic health centers need to incorporate changes in their curricula to train socially responsible and idealistic physicians. International electives can provide valuable learning experiences to help achieve these goals. METHODS Sixty-six preclinical medical students at the University of Texas Medical Branch participated in an international elective from 1997 to 2005. After 1 week of didactics, they spent 3 weeks as part of a multidisciplinary medical team in rural Nicaragua. Postelective questionnaires were administered. From students’ responses, we identified common learning themes and grouped them under the categories of attitudes, awareness, and skills. Limitations included a self-selection bias, lack of a control group, and limited follow-up. RESULTS After the elective, students had an increased interest in volunteerism, humanitarian efforts, and working with underserved populations both in the United States and abroad, as well as more compassion toward the underserved. Students also reported a heightened awareness of social determinants of health and public health, and a broadened global perspective, as well as increased self-awareness. CONCLUSIONS Our findings illustrate that a well-structured, mentored experience in international health can have a positive impact on preclinical students’ attitudes, including their compassion, volunteerism, and interest in serving under-served populations, all measures of idealism. PMID:17003160

  18. Capturing medical students' idealism.

    Science.gov (United States)

    Smith, Janice K; Weaver, Donna B

    2006-01-01

    Students' idealism and desire to work with underserved populations decline as they progress from preclinical training through clerkships and residency. With an increasingly diverse population and increasing health disparities, academic health centers need to incorporate changes in their curricula to train socially responsible and idealistic physicians. International electives can provide valuable learning experiences to help achieve these goals. Sixty-six preclinical medical students at the University of Texas Medical Branch participated in an international elective from 1997 to 2005. After 1 week of didactics, they spent 3 weeks as part of a multidisciplinary medical team in rural Nicaragua. Postelective questionnaires were administered. From students' responses, we identified common learning themes and grouped them under the categories of attitudes, awareness, and skills. Limitations included a self-selection bias, lack of a control group, and limited follow-up. After the elective, students had an increased interest in volunteerism, humanitarian efforts, and working with underserved populations both in the United States and abroad, as well as more compassion toward the underserved. Students also reported a heightened awareness of social determinants of health and public health, and a broadened global perspective, as well as increased self-awareness. Our findings illustrate that a well-structured, mentored experience in international health can have a positive impact on preclinical students' attitudes, including their compassion, volunteerism, and interest in serving under-served populations, all measures of idealism.

  19. Localised hydrogen peroxide sensing for reproductive health

    Science.gov (United States)

    Purdey, Malcolm S.; Schartner, Erik P.; Sutton-McDowall, Melanie L.; Ritter, Lesley J.; Thompson, Jeremy G.; Monro, Tanya M.; Abell, Andrew D.

    2015-05-01

    The production of reactive oxygen species (ROS) is known to affect the developmental competence of embryos. Hydrogen peroxide (H2O2) an important reactive oxygen species, is also known to causes DNA damage and defective sperm function. Current techniques require incubating a developing embryo with an organic fluorophore which is potentially hazardous for the embryo. What we need is a localised ROS sensor which does not require fluorophores in solution and hence will allow continuous monitoring of H2O2 production without adversely affect the development of the embryo. Here we report studies on such a fibre-based sensor for the detection of H2O2 that uses a surface-bound aryl boronate fluorophore carboxyperoxyfluor-1(CPF1). Optical fibres present a unique platform due to desirable characteristics as dip sensors in biological solutions. Attempts to functionalise the fibre tips using polyelectrolyte layers and (3-aminopropyl)triethoxysilane (APTES) coatings resulted in a limited signal and poor fluorescent response to H2O2 due to a low tip surface density of the fluorophore. To increase the surface density, CPF1 was integrated into a polymer matrix formed on the fibre tip by a UV-catalysed polymerisation process of acrylamide onto a methacrylate silane layer. The polyacrylamide containing CPF1 gave a much higher surface density than previous surface attachment methods and the sensor was found to effectively detect H2O2. Using this method, biologically relevant concentrations of H2O2 were detected, enabling remote sensing studies into ROS releases from embryos throughout early development.

  20. Alexander duals of multipermutohedron ideals

    Indian Academy of Sciences (India)

    for all the multigraded Betti numbers of an Alexander dual of multipermutohedron ideals are also obtained. ... the permutohedron ideal I(1, 2,...,n) with respect to n = (n, n, . . . , n) is given by. I(1, 2,...,n). [n] = 〈. (∏ .... of the Betti numbers of multipermutohedron ideals and characterization of minimality of the cellular resolution ...

  1. Sub-pixel localisation of passive micro-coil fiducial markers in interventional MRI.

    Science.gov (United States)

    Rea, Marc; McRobbie, Donald; Elhawary, Haytham; Tse, Zion T H; Lamperth, Michael; Young, Ian

    2009-04-01

    Electromechanical devices enable increased accuracy in surgical procedures, and the recent development of MRI-compatible mechatronics permits the use of MRI for real-time image guidance. Integrated imaging of resonant micro-coil fiducials provides an accurate method of tracking devices in a scanner with increased flexibility compared to gradient tracking. Here we report on the ability of ten different image-processing algorithms to track micro-coil fiducials with sub-pixel accuracy. Five algorithms: maximum pixel, barycentric weighting, linear interpolation, quadratic fitting and Gaussian fitting were applied both directly to the pixel intensity matrix and to the cross-correlation matrix obtained by 2D convolution with a reference image. Using images of a 3 mm fiducial marker and a pixel size of 1.1 mm, intensity linear interpolation, which calculates the position of the fiducial centre by interpolating the pixel data to find the fiducial edges, was found to give the best performance for minimal computing power; a maximum error of 0.22 mm was observed in fiducial localisation for displacements up to 40 mm. The inherent standard deviation of fiducial localisation was 0.04 mm. This work enables greater accuracy to be achieved in passive fiducial tracking.

  2. Essai de classification des prépositions de localisation

    Directory of Open Access Journals (Sweden)

    Le Pesant Denis

    2012-07-01

    Full Text Available Nous avons relevé 205 prépositions de localisation, qui sont, pour près de 90% d’entre elles, des locutions. Nous proposons d’abord une définition syntaxique des prépositions de localisation. Nous étudions ensuite leurs principales propriétés morphosyntaxiques. Nous nous attardons plus particulièrement sur les noms qui entrent dans la composition de la majorité des locutions de localisation et qui, tels "le haut", "le bas", "le dessus", "le bord", "le centre", ont par ailleurs un emploi libre. Ils se répartissent entre deux catégories : les noms de portions (ex. "le haut", "le bas" et les noms de termes, à savoir les noms de limites (ex. "le dessus", "le bord" et les noms de milieu (ex. "le milieu", "le centre". Notre thèse est que la sémantique des prépositions de localisation est héritée de la sémantique de ces noms. Nous présentons ensuite un essai de classification sémantique. Nous postulons que les diverses sortes de relations de localisation interne (avec ou sans contact ou de localisation externe (avec ou sans contact ne s’établissent pas par rapport à l’objet point de repère (le « site » en tant que tel, mais par rapport à une des portions ou un des termes (limite ou milieu de ce dernier, lesquels remplissent la fonction de « médiateurs de la localisation ». Six catégories générales sont ainsi distinguées : les prépositions de localisation interne par rapport à une limite ou une portion ; les prépositions de localisation interne ou externe avec contact par rapport à une limite ou une portion ; les prépositions de localisation externe avec ou sans contact par rapport à une limite ou une portion ; les prépositions de localisation externe avec contact par rapport à des limites ou surfaces ; les prépositions de localisation externe sans contact par rapport à des limites ; les prépositions de localisation externe avec contact par rapport au terme intermédiaire (le milieu. Ces cat

  3. Optimal Scale Edge Detection Utilizing Noise within Images

    Directory of Open Access Journals (Sweden)

    Adnan Khashman

    2003-04-01

    Full Text Available Edge detection techniques have common problems that include poor edge detection in low contrast images, speed of recognition and high computational cost. An efficient solution to the edge detection of objects in low to high contrast images is scale space analysis. However, this approach is time consuming and computationally expensive. These expenses can be marginally reduced if an optimal scale is found in scale space edge detection. This paper presents a new approach to detecting objects within images using noise within the images. The novel idea is based on selecting one optimal scale for the entire image at which scale space edge detection can be applied. The selection of an ideal scale is based on the hypothesis that "the optimal edge detection scale (ideal scale depends on the noise within an image". This paper aims at providing the experimental evidence on the relationship between the optimal scale and the noise within images.

  4. Electron transport in edge-disordered graphene nanoribbons

    DEFF Research Database (Denmark)

    Saloriutta, Karri; Hancock, Y.; Karkkainen, Asta

    2011-01-01

    Ab initio methods are used to study the spin-resolved transport properties of graphene nanoribbons (GNRs) that have both chemical and structural edge disorder. Oxygen edge adsorbates on ideal and protruded ribbons are chosen as representative examples, with the protrusions forming the smallest...

  5. On localised hotspots of an urban crime model

    Science.gov (United States)

    Lloyd, David J. B.; O'Farrell, Hayley

    2013-06-01

    We investigate stationary, spatially localised crime hotspots on the real line and the plane of an urban crime model of Short et al. [M. Short, M. DÓrsogna, A statistical model of criminal behavior, Mathematical Models and Methods in Applied Sciences 18 (2008) 1249-1267]. Extending the weakly nonlinear analysis of Short et al., we show in one-dimension that localised hotspots should bifurcate off the background spatially homogeneous state at a Turing instability provided the bifurcation is subcritical. Using path-following techniques, we continue these hotspots and show that the bifurcating pulses can undergo the process of homoclinic snaking near the singular limit. We analyse the singular limit to explain the existence of spike solutions and compare the analytical results with the numerical computations. In two-dimensions, we show that localised radial spots should also bifurcate off the spatially homogeneous background state. Localised planar hexagon fronts and hexagon patches are found and depending on the proximity to the singular limit these solutions either undergo homoclinic snaking or act like “multi-spot” solutions. Finally, we discuss applications of these localised patterns in the urban crime context and the full agent-based model.

  6. Space Sciences and Idealism

    Science.gov (United States)

    Popov, M.

    Erwin Schrodinger suggested that " Scientific knowledge forms part of the idealistic background of human life", which exalted man from a nude and savage state to true humanity [Science and Humanism, Cambridge, 1961, p9]. Modern space sciences an space exploration are a brilliant demonstration of the validity of Schrodinger's thesis on Idealism. Moreover, Schrodingers thesis could be considered also as a basic principle for the New Educational Space Philosophical Project "TIMAEUS"."TIMAEUS" is not only an attempt to to start a new dialogue between Science, the Humanities and Religion; but also it is an origin of the cultural innovations of our so strange of globilisation. TIMAEUS, thus, can reveal Idealism as something more fundamental , more refined, more developed than is now accepted by the scientific community and the piblic. TIMAEUS has a significant cultural agenda, connected with the high orbital performance of the synthetic arts, combining a knowledge of the truly spiritual as well as the universal. In particular, classical ballet as a synthetic art can be a new and powerful perfector and re-creator of the real human, real idealistic, real complex culture in orbit. As is well known, Carlo Blasis, the most important dance theorist of the 19t h .century, made probably the first attempts to use the scientific ideas of Leonardo da Vinci and Isaac Newton for the understanding of the gravitational nature of balance and allegro in ballet. In particular Blasis's idea of the limited use of the legs in classical dance realised by the gifted pupils of Enrico Cecchetti - M.Fokine, A.Pavlova and V.Nijinsky, with thinkable purity and elegance of style. V.Nijinsky in his remarkable animation of the dance of two dimensional creatures of a Euclidean flat world (L'Apres Midi d'un Faune,1912) discovered that true classical dance has some gravitational limits. For example, Nijinsky's Faunes and Nymphs mut use running on the heels (In accordance with "Partitura" 1916); they

  7. The realities of idealism.

    Science.gov (United States)

    Roslyn, J J

    1993-04-01

    I started out asking the question can we achieve our goals and are our goals realistic in the 1990s? I believe that we can achieve anything that we set our minds to. Our goals of providing quality care to our patients, performing research, teaching the next generation, and having an impact on our local environment are worth pursuing. However, the rules have changed and the status quo is simply not good enough. If we are to survive, we must be prepared for the future. You have the ability to change and the power to control the future. You are the future. Seize the opportunity and get involved. Become knowledgeable about health care economics, become involved with the political process, and position yourselves so that you can be a part of the solution to our health care system's woes. Don't allow the moment to pass. Don't be afraid of the realities of today, and don't forget your ideals and principles. Confront today's challenges with the same determination that academic surgeons through the years have confronted the unknown mysteries of disease. Let me conclude by trying to synthesize my remarks in five generic recommendations: 1. We need to go forward in the research area by developing multidisciplinary programs that involve basic science. These programs can be used to highlight our clinical areas and expertise. In this manner, both areas will be benefitted. 2. We need to educate the public and the government about the virtues of research and the importance of maintaining academic surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

  8. Differences in finger localisation performance of patients with finger agnosia.

    Science.gov (United States)

    Anema, Helen A; Kessels, Roy P C; de Haan, Edward H F; Kappelle, L Jaap; Leijten, Frans S; van Zandvoort, Martine J E; Dijkerman, H Chris

    2008-09-17

    Several neuropsychological studies have suggested parallel processing of somatosensory input when localising a tactile stimulus on one's own by pointing towards it (body schema) and when localising this touched location by pointing to it on a map of a hand (body image). Usually these reports describe patients with impaired detection, but intact sensorimotor localisation. This study examined three patients with a lesion of the angular gyrus with intact somatosensory processing, but with selectively disturbed finger identification (finger agnosia). These patients performed normally when pointing towards the touched finger on their own hand but failed to indicate this finger on a drawing of a hand or to name it. Similar defects in the perception of other body parts were not observed. The findings provide converging evidence for the dissociation between body image and body schema and, more importantly, reveal for the first time that this distinction is also present in higher-order cognitive processes selectively for the fingers.

  9. S — Compactness Via Ideals

    OpenAIRE

    Abdel Monsef, M. E. [محمد عزت عبد المنصف; Lashien, E. F.; Nasef, A. A.

    1991-01-01

    Compactness modulo as an ideal has not been widely studied. Many new sorts of weak compactness have been introduced to topological spaces in the last twenty years but have not been studied using ideals. So, the main aim of our work is to study relations between ideals and some types of weak compactness. We initiate types of compactness modulo an ideal that generalize semi-compactness, S-closeness, S-Lindelofness and other types of compactness. Moreover, we study some of their properties and c...

  10. An Ideal Integrating Bolometer Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An ideal integrating bolometer can achieve breakthrough sensitivity in IR photon detection by removing practical barriers to extreme thermal isolation of the...

  11. Monitoring corrosion rates and localised corrosion in low conductivity water

    DEFF Research Database (Denmark)

    Hilbert, Lisbeth Rischel

    2006-01-01

    Monitoring of low corrosion rates and localised corrosion in a media with low conductivity is a challenge. In municipal district heating, quality control may be improved by implementing on-line corrosion monitoring if a suitable technique can be identified to measure both uniform and localised...... corrosion. Electrochemical techniques (LPR, EIS, crevice corrosion current) as well as direct measurement techniques (high-sensitive electrical resistance, weight loss) have been applied in operating plants. Changes in the corrosion processes are best monitored in non-aggressive, low conductivity media...... with sensitive electrical resistance technique and crevice corrosion current measurements....

  12. Fusion rings and fusion ideals

    DEFF Research Database (Denmark)

    Andersen, Troels Bak

    by the so-called fusion ideals. The fusion rings of Wess-Zumino-Witten models have been widely studied and are well understood in terms of precise combinatorial descriptions and explicit generating sets of the fusion ideals. They also appear in another, more general, setting via tilting modules for quantum...

  13. Follow-up in patients with localised primary cutaneous melanoma

    NARCIS (Netherlands)

    Francken, AB; Bastiaannet, E; Hoekstra, HJ

    Follow-up services for patients with localised cutaneous melanoma are widely discussed but there is no international consensus. Our aim was to discuss frequency and duration of follow-up, type of health professional involved, optimum intensity of routine investigation, and patients' satisfaction

  14. Nationalisation, Localisation and Globalisation in Finnish Higher Education

    Science.gov (United States)

    Valimaa, Jussi

    2004-01-01

    This article analyses and discusses the interplay between the social processes of nationalisation, localisation and globalisation in a single European nation state. The view of nationalisation put forward draws on a national case study based on historical and sociological research findings. The second part of the article presents a case study of…

  15. Scanning Kelvin Probe applied to localised corrosion | Haque ...

    African Journals Online (AJOL)

    This paper focuses on specific applications of the SKP system. The instrument is calibrated, using different thickness of a model polymer Poly Vinyl Butyral (PVB) on mild steel and on galvanised steel. Artificial defects are used to show how the instrument is capable of detecting a localised corrosion cell and its ability to ...

  16. Application of the Localisation Platform Crowdin in Translator Education

    Science.gov (United States)

    Kudla, Dominik

    2017-01-01

    This article is an attempt to briefly describe the potential of the online localisation platform Crowdin for the education of the future translators at universities and in private courses or workshops. This description is provided on the basis of the information gathered through the user experience of the author and uses the example of the Khan…

  17. Diagnostic value of high resolution ultrasound in localisation of the ...

    African Journals Online (AJOL)

    Background: The use of ultrasonography in the pre-operative localisation of undescended testes has become controversial due to fears about its accuracy. This study was designed to ascertain the accuracy, sensitivity, specifi city, positive predictive value (PPV) and negative predictive value (NPV) of ultrasonography in the ...

  18. Nanoindentation near the edge

    Science.gov (United States)

    J.E. Jakes; C.R. Frihart; J.F. Beecher; R.J. Moon; P.J. Resto; Z.H. Melgarejo; O.M. Saurez; H. Baumgart; A.A. Elmustafa; D.S. Stone

    2009-01-01

    Whenever a nanoindent is placed near an edge, such as the free edge of the specimen or heterophase interface intersecting the surface, the elastic discontinuity associated with the edge produces artifacts in the load-depth data. Unless properly handled in the data analysis, the artifacts can produce spurious results that obscure any real trends in properties as...

  19. Bremstrahlung Detection and Chamber Obstruction Localisation Using Scanning Radiation Detectors

    CERN Document Server

    Naylor, G A; Robinson, D

    2005-01-01

    Radiation monitors consisting of scintillating plastic coupled to photomultipliers are used for diagnostic purposes. By scanning such a detector or a radiation scatterer, two applications are demonstrated: i) Monitoring of vacuum chamber conditioning by monitoring gas Bremstrahlung from residual gas. ii) Localisation of beam interception (beam losses) by longitudinal scanning of a radiation detector. The measurement of gas pressure inside long, small cross section, vacuum vessels is difficult due to the distance between the centre of the vacuum vessel and vacuum gauges (leading to a low vacuum conductance). The narrow beam of gamma Bremstrahlung radiation is intercepted by scanning tungsten blades in the beam line front-end allowing a radiation shower to be detected outside the vacuum vessel proportional to the gas pressure in the corresponding storage ring straight section. A second detector mounted on rails can be moved over a length of 6.5m parallel to the ESRF storage ring so as to localise regions of bea...

  20. Diagnostic et traitement de la Maladie du charbon à localisation ...

    African Journals Online (AJOL)

    Les auteurs rapportent l'observation d'un patient admis dans un tableau de cellulite préseptale, avec escarre noirâtre étendue de la paupière supérieure et oedème extensif de l´hémiface, faisant suspecter une localisation palpébrale de la maladie du charbon. L'examen bactériologique a permis de confirmer le diagnostic.

  1. Localisation of AMPK γ subunits in cardiac and skeletal muscles.

    Science.gov (United States)

    Pinter, Katalin; Grignani, Robert T; Watkins, Hugh; Redwood, Charles

    2013-12-01

    The trimeric protein AMP-activated protein kinase (AMPK) is an important sensor of energetic status and cellular stress, and mutations in genes encoding two of the regulatory γ subunits cause inherited disorders of either cardiac or skeletal muscle. AMPKγ2 mutations cause hypertrophic cardiomyopathy with glycogen deposition and conduction abnormalities; mutations in AMPKγ3 result in increased skeletal muscle glycogen. In order to gain further insight into the roles of the different γ subunits in muscle and into possible disease mechanisms, we localised the γ2 and γ3 subunits, along with the more abundant γ1 subunit, by immunofluorescence in cardiomyocytes and skeletal muscle fibres. The predominant cardiac γ2 variant, γ2-3B, gave a striated pattern in cardiomyocytes, aligning with the Z-disk but with punctate staining similar to T-tubule (L-type Ca(2+) channel) and sarcoplasmic reticulum (SERCA2) markers. In skeletal muscle fibres AMPKγ3 localises to the I band, presenting a uniform staining that flanks the Z-disk, also coinciding with the position of Ca(2+) influx in these muscles. The localisation of γ2-3B- and γ3-containing AMPK suggests that these trimers may have similar functions in the different muscles. AMPK containing γ2-3B was detected in oxidative skeletal muscles which had low expression of γ3, confirming that these two regulatory subunits may be co-ordinately regulated in response to metabolic requirements. Compartmentalisation of AMPK complexes is most likely dependent on the regulatory γ subunit and this differential localisation may direct substrate selection and specify particular functional roles.

  2. Anderson localisation in tight-binding models with flat bands

    OpenAIRE

    Chalker, J. T.; Pickles, T. S.; Shukla, Pragya

    2010-01-01

    We consider the effect of weak disorder on eigenstates in a special class of tight-binding models. Models in this class have short-range hopping on periodic lattices; their defining feature is that the clean systems have some energy bands that are dispersionless throughout the Brillouin zone. We show that states derived from these flat bands are generically critical in the presence of weak disorder, being neither Anderson localised nor spatially extended. Further, we establish a mapping betwe...

  3. Kyste hydatique à localisation costo vertébrale

    Science.gov (United States)

    Marouf, Rachid

    2014-01-01

    L'hydatidose est une affection parasitaire due à la contamination de l'homme par la forme larvaire de ténia échinococcus granulosus, la forme costo vertébrale est une localisation très rare qui représente 0,18 à 1,21% de l'ensemble des localisations hydatiques. Nous rapportons le cas d'une femme de 32 ans qui présente un kyste hydatique multi vésiculaire à localisation costovertébrale, traité par chirurgie radicale associée à un traitement médical anti parasitaire pour une durée de 6 mois, avec bonne évolution. L'atteinte costo-vertébrale par la maladie hydatique est rare et l’évolution est insidieuse. Malgré un traitement chirurgical radical, la fréquence des récidives rend le pronostic sombre. PMID:25922632

  4. Diagnostic approach to localised organising pneumonia--A case report.

    Science.gov (United States)

    Djurić, Mirna; Považan, Djordje; Djurić, Dejan; Eri, Živka; Trudić, Anika

    2015-08-01

    Localised organising pneumonia, radiologically presented with oval or round shadows mimicing lung cancer or metastases, is a major issue in differential diagnosis. A female patient was hospitalized to clarified the etiology of multiple nodular lung lesions. The chest X-ray and the chest computed tomography (CT) revealed bilateral patchy and nodular shadows, and round lung lesions, respectively. Neither sputum analyses, nor histology of bronchoscopy samples clarified the etiology of these lung lesions. As secondary deposits in the lungs were suspected, video-assisted thoracoscopy and anterolateral right minithoracotomy with atypical upper and lower lobe resection were performed. The frozen-section analysis suggested the benign nature of the lesion, and the definite histopathological finding of localised organising pneumonia was established. Due to bilateral lung lesions, corticosteroids were applied. Seven weeks later, the chest CT finding revealed a total regression of the lesions. A surgical resection was necessary to diagnose the localised organising pneumonia which mimiced secondary malignant lesions, thus establishing the definite etiology of lung lesions. Bronchoscopic cryobiopsy, recently introduced in order to obtain peripheral lung biopsy samples, has provided new possibilities in the diagnosis and treatment of neoplastic and non-neoplastic lung diseases.

  5. Plastic Collapse Localisation in Simple Shearing and Coaxial Deformations

    Science.gov (United States)

    Hobbs, B. E.; Ord, A.

    2011-12-01

    We explore, numerically, the evolution of localisation due to plastic collapse in both coaxial shortening and simple shearing deformations. These localisation features arise from plastic behaviour and hence differ from the formation of anticracks modelled by linear elastic behaviour (Fletcher and Pollard, 1990). The behaviour is close to that discussed by Rudnicki (2004) and Chemenda (2009) in that localisation consists of zones of plastic collapse separated by elastically unloaded regions. The constitutive behaviour assumed here comprises a Tresca yield with both strain-softening of the yield stress and of a cap that models plastic volumetric collapse during phase transformations, such as the olivine-spinel transition, with ΔVSudbury, Ontario, Canada, October 2003. R. Brummer (Ed), Balkema, 27-33. Fletcher, R.C., Pollard, D.D., 1990. Anticrack model for pressure solution surfaces. Geology 9, 419- 424. Green, H.W., Burnley, P.C., 1989. A new self-organizing mechanism for deep-focus earthquakes. Nature, 341, 733- 737. Issen, K.A., Rudnicki, J.W., 2000. Conditions for compaction bands in porous rocks. J. Geophys. Res. 105, 21,529-21,536. Rudnicki, J. W. 2004. Shear and compaction band formation on an elliptic yield cap. J. Geophys. Res., 109, B03402. Veveakis, E., Alevizos, S., & Vardoulakis, I. 2010. Chemical reaction capping of thermal instabilities during shear of frictional faults. Journal of the Mechanics and Physics of Solids. 58, 1175-1194.

  6. Recognising upright and inverted faces: MEG source localisation.

    Science.gov (United States)

    Taylor, M J; Bayless, S J; Mills, T; Pang, E W

    2011-03-24

    Face recognition is a complex cognitive task that involves a distributed network of neural sources. While some components of this network have been identified, the temporal sequence of these components is not well understood. Magnetoencephalography (MEG), analyzed with a spatial filtering source localisation algorithm, was used to determine frontal contributions to face recognition. We tested 22 adults (mean age 26.3 years; 10 females). Upright and inverted faces were presented in counter-balanced blocks and subjects identified repetitions in a 1-back protocol. MEG data were recorded continuously from a 151 channel CTF machine and source localised to each participant's MRI. The classic face components, M100 and M170, were seen for upright and inverted faces with M100 localizing to bilateral occipital areas and M170 to bilateral fusiform areas. A third component, M240, showed high global field power to correctly recognised repeated faces and localised to right middle frontal and insula sources at 240 ms for upright faces and bilateral mid-frontal sources for inverted faces. The effect of repetition was examined and a source identified at 250 ms in the cingulate, for inverted faces. These results provide timing information on frontal lobe activation, seen reliably in fMRI memory studies; the immediate recognition of repeated faces activates the right frontal sources at 240-250 ms, with bilateral activation to repeated inverted faces, perhaps due to increased task difficulty. Copyright © 2011 Elsevier B.V. All rights reserved.

  7. Tensor norms and operator ideals

    CERN Document Server

    Defant, A; Floret, K

    1992-01-01

    The three chapters of this book are entitled Basic Concepts, Tensor Norms, and Special Topics. The first may serve as part of an introductory course in Functional Analysis since it shows the powerful use of the projective and injective tensor norms, as well as the basics of the theory of operator ideals. The second chapter is the main part of the book: it presents the theory of tensor norms as designed by Grothendieck in the Resumé and deals with the relation between tensor norms and operator ideals. The last chapter deals with special questions. Each section is accompanied by a series of exer

  8. An ideal free-kick

    Science.gov (United States)

    De Luca, R.; Faella, O.

    2017-01-01

    The kinematics of a free-kick is studied. As in projectile motion, the free-kick is ideal since we assume that a point-like ball moves in the absence of air resistance. We have experienced the fortunate conjuncture of a classical mechanics lecture taught right before an important football game. These types of sports events might trigger a great deal of attention from the classroom. The idealized problem is devised in such a way that students are eager to come to the end of the whole story.

  9. Idealism and materialism in perception.

    Science.gov (United States)

    Rose, David; Brown, Dora

    2015-01-01

    Koenderink (2014, Perception, 43, 1-6) has said most Perception readers are deluded, because they believe an 'All Seeing Eye' observes an objective reality. We trace the source of Koenderink's assertion to his metaphysical idealism, and point to two major weaknesses in his position-namely, its dualism and foundationalism. We counter with arguments from modern philosophy of science for the existence of an objective material reality, contrast Koenderink's enactivism to his idealism, and point to ways in which phenomenology and cognitive science are complementary and not mutually exclusive.

  10. Certain variants of multipermutohedron ideals

    Indian Academy of Sciences (India)

    016-0313-4. Certain variants of multipermutohedron ideals. AJAY KUMAR1,2 and CHANCHAL KUMAR1,∗. 1Indian Institute of ... 2010 Mathematics Subject Classification. 05E40 .... eral questions and conjectures from [10] and [5]. In particular ...

  11. DTUsat the Ideal CDIO project

    DEFF Research Database (Denmark)

    Fléron, René

    2016-01-01

    solution is likewise challenging. The conceiving, designing, implementation and operation phases in the CDIO education aims to bring the student through a scenario simulating real life engineering. A satellite mission constitutes an ideal case for a CDIO project. Designing, building, launching...

  12. Convex analysis and ideal tensegrities

    Science.gov (United States)

    Maceri, Franco; Marino, Michele; Vairo, Giuseppe

    2011-11-01

    A theoretical framework based on convex analysis is formulated and developed to study tensegrity structures under steady-state loads. Many classical results for ideal tensegrities are rationally deduced from subdifferentiable models in a novel mechanical perspective. Novel energy-based criteria for rigidity and pre-stressability are provided, allowing to formulate numerical algorithms for computations.

  13. Physics of skiing: The ideal-carving equation and its applications

    Science.gov (United States)

    Jentschura, U. D.; Fahrbach, F.

    2004-04-01

    Ideal carving occurs when a snowboarder or skier, equipped with a snowboard or carving skis, describes a perfectly carved turn in which the edges of the ski alone, not the ski surface, describe the trajectory followed by the skier, without any slipping or skidding. In this article, we derive the "ideal-carving" equation that describes the physics of a carved turn under ideal conditions. The laws of Newtonian classical mechanics are applied. The parameters of the ideal-carving equation are the inclination of the ski slope, the acceleration of gravity, and the sidecut radius of the ski. The variables of the ideal-carving equation are the velocity of the skier, the angle between the trajectory of the skier and the horizontal, and the instantaneous curvature radius of the skier's trajectory. Relations between the slope inclination and the velocity range suited for nearly ideal carving are discussed, as well as implications for the design of carving skis and snowboards.

  14. Edge colouring by total labellings

    DEFF Research Database (Denmark)

    Brandt, Stephan; Rautenbach, D.; Stiebitz, M.

    2010-01-01

    We introduce the concept of an edge-colouring total k-labelling. This is a labelling of the vertices and the edges of a graph G with labels 1, 2, ..., k such that the weights of the edges define a proper edge colouring of G. Here the weight of an edge is the sum of its label and the labels of its...

  15. Adobe Edge Quickstart Guide

    CERN Document Server

    Labrecque, Joseph

    2012-01-01

    Adobe Edge Quickstart Guide is a practical guide on creating engaging content for the Web with Adobe's newest HTML5 tool. By taking a chapter-by-chapter look at each major aspect of Adobe Edge, the book lets you digest the available features in small, easily understandable chunks, allowing you to start using Adobe Edge for your web design needs immediately. If you are interested in creating engaging motion and interactive compositions using web standards with professional tooling, then this book is for you. Those with a background in Flash Professional wanting to get started quickly with Adobe

  16. RFID Localisation For Internet Of Things Smart Homes: A Survey

    OpenAIRE

    Alsinglawi, Belal; Elkhodr, Mahmoud; Nguyen, Quang Vinh; Gunawardana, Upul; Maeder, Anthony; Simoff, Simeon

    2017-01-01

    The Internet of Things (IoT) enables numerous business opportunities in fields as diverse as e-health, smart cities, smart homes, among many others. The IoT incorporates multiple long-range, short-range, and personal area wireless networks and technologies into the designs of IoT applications. Localisation in indoor positioning systems plays an important role in the IoT. Location Based IoT applications range from tracking objects and people in real-time, assets management, agriculture, assist...

  17. Active surveillance strategy for patients with localised prostate cancer

    DEFF Research Database (Denmark)

    Thomsen, Frederik Birkebæk

    2014-01-01

    BACKGROUND: Active surveillance - an initial observational strategy - offers a tailored management of patients with localised prostate cancer. The aim of the strategy is to appoint patients with potentially lethal prostate cancer to curatively intended treatment, while patients with slowly evolving...... with defined final histopathological findings at radical prostatectomy that was perceived as unacceptable for a continued observational strategy. CONCLUSION: The thesis has demonstrated that active surveillance is feasible and reduces the number of patients undergoing curative intended treatment. However...... in the management of prostate cancer patients on active surveillance is emphasised....

  18. The Ideal of Moral Autonomy

    Directory of Open Access Journals (Sweden)

    Ricardo Marquisio Aguirre

    2017-10-01

    Full Text Available Some elements of the ideal of moral autonomy are discussed in this paper. Such ideal is a key assumption in social practices focused on normative imputation, particularly morality and law. First, a constructivist conception of normativity is introduced, taking reasons as an essential and non-reducible element, and focused on the conceptual features of moral reasons within the normative domain. Then, an idea of moral autonomy based on the self-constitution is developed including three key features: the possibility of responding to reasons based on shared social expectations; the responsibility for certain scope of actions, according to a set of reasons available to the individual and to their maximum extent of expansion; and the need to preserve autonomy as a purpose unifying the set of autonomous actions of moral agents.

  19. Named Entity Recognition for IDEAL

    OpenAIRE

    Du, Qianzhou; Zhang, Xuan

    2015-01-01

    This project explored how to apply Named Entity Recognition to large Twitter and web page datasets to extract useful entities such as people, organization, location, and date. In addition, this NER utility has been scaled to the MapReduce framework on the Hadoop cluster. A schema and software allow this to be integrated with IDEAL. The term “Named Entity”, which was first introduced by Grishman and Sundheim, is widely used in Natural Language Processing (NLP). The researchers were focusing...

  20. Hyperfuzzy Ideals in BCK/BCI-Algebras

    Directory of Open Access Journals (Sweden)

    Seok-Zun Song

    2017-12-01

    Full Text Available The notions of hyperfuzzy ideals in B C K / B C I -algebras are introduced, and related properties are investigated. Characterizations of hyperfuzzy ideals are established. Relations between hyperfuzzy ideals and hyperfuzzy subalgebras are discussed. Conditions for hyperfuzzy subalgebras to be hyperfuzzy ideals are provided.

  1. Strong ideal convergence in probabilistic metric spaces

    Indian Academy of Sciences (India)

    In the present paper we introduce the concepts of strongly ideal convergent sequence and strong ideal Cauchy sequence in a probabilistic metric (PM) space endowed with the strong topology, and establish some basic facts. Next, we define the strong ideal limit points and the strong ideal cluster points of a sequence in this ...

  2. Strong ideal convergence in probabilistic metric spaces

    Indian Academy of Sciences (India)

    Abstract. In the present paper we introduce the concepts of strongly ideal convergent sequence and strong ideal Cauchy sequence in a probabilistic metric (PM) space endowed with the strong topology, and establish some basic facts. Next, we define the strong ideal limit points and the strong ideal cluster points of a ...

  3. Localisation of Dopamine D1-Like and D2-Like Receptors in the Pulmonary Vasculature

    National Research Council Canada - National Science Library

    Kobayashi, Yuta; Amenta, Francesco; Ricci, Alberto; Hattori, Keisuke

    1995-01-01

    The pharmacological profile and the anatomical localisation of dopamine receptor subtypes were investigated in the rabbit pulmonary vascular bed using combined radioligand binding and light microscope...

  4. Adobe Edge Preview 3

    CERN Document Server

    Grover, Chris

    2011-01-01

    Want to use an Adobe tool to design animated web graphics that work on iPhone and iPad? You've come to the right book. Adobe Edge Preview 3: The Missing Manual shows you how to build HTML5 graphics using simple visual tools. No programming experience? No problem. Adobe Edge writes the underlying code for you. With this eBook, you'll be designing great-looking web elements in no time. Get to know the workspace. Learn how Adobe Edge Preview 3 performs its magic.Create and import graphics. Make drawings with Edge's tools, or use art you designed in other programs.Work with text. Build menus, lab

  5. Edge Simulation Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Krasheninnikov, Sergei I. [Univ. of California, San Diego, CA (United States); Angus, Justin [Univ. of California, San Diego, CA (United States); Lee, Wonjae [Univ. of California, San Diego, CA (United States)

    2018-01-05

    The goal of the Edge Simulation Laboratory (ESL) multi-institutional project is to advance scientific understanding of the edge plasma region of magnetic fusion devices via a coordinated effort utilizing modern computing resources, advanced algorithms, and ongoing theoretical development. The UCSD team was involved in the development of the COGENT code for kinetic studies across a magnetic separatrix. This work included a kinetic treatment of electrons and multiple ion species (impurities) and accurate collision operators.

  6. The fate of idealism in modern medicine.

    Science.gov (United States)

    Manson, Aaron

    1994-01-01

    William Osler's description of the ideal physician remains the dominant character-ideal for modern physicians. He believed that the personality traits that resulted from a belief in ascetic Protestantism, what has been called the Puritan temper, were essential in the practice of medicine. However, this idealism has been weakened by modern psychological theories which view idealism as an illness. In a culture oriented to health, rather than virtue, as an ultimate ideal, physicians can help develop a science of limits.

  7. Investigation into Generation of Micro Features by Localised Electrochemical Deposition

    Science.gov (United States)

    Debnath, Subhrajit; Laskar, Hanimur Rahaman; Bhattacharyya, B.

    2017-11-01

    With the fast advancement of technology, localised electrochemical deposition (LECD) is becoming very advantageous in generating high aspect ratio micro features to meet the steep demand in modern precision industries of the present world. Except many other advantages, this technology is highly uncomplicated and economical for fabricating metal micro-parts with in micron ranges. In the present study, copper micro-columns have been fabricated utilizing LECD process. Different process parameters such as voltage, frequency, duty ratio and electrolyte concentration, which affect the deposition performance have been identified and their effects on deposition performances such as deposition rate, height and diameter of the micro-columns have been experimentally investigated. Taguchi's methodology has been used to study the effects as well as to obtain the optimum values of process parameters so that localised deposition with best performance can be achieved. Moreover, the generated micro-columns were carefully observed under optical and scanning electron microscope from where the surface quality of the deposited micro-columns has been studied qualitatively. Also, an array of copper micro-columns has been fabricated on stainless steel (SS-304) substrate for further exploration of LECD process capability.

  8. An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids

    Directory of Open Access Journals (Sweden)

    Harriet Allison

    2014-10-01

    Full Text Available African trypanosomes are evolutionarily highly divergent parasitic protozoa, and as a consequence the vast majority of trypanosome membrane proteins remain uncharacterised in terms of location, trafficking or function. Here we describe a novel family of type I membrane proteins which we designate ‘invariant glycoproteins’ (IGPs. IGPs are trypanosome-restricted, with extensive, lineage-specific paralogous expansions in related taxa. In T. brucei three IGP subfamilies, IGP34, IGP40 and IGP48 are recognised; all possess a putative C-type lectin ectodomain and are ER-localised, despite lacking a classical ER-retention motif. IGPs exhibit highest expression in stumpy stage cells, suggesting roles in developmental progression, but gene silencing in mammalian infective forms suggests that each IGP subfamily is also required for normal proliferation. Detailed analysis of the IGP48 subfamily indicates a role in maintaining ER morphology, while the ER lumenal domain is necessary and sufficient for formation of both oligomeric complexes and ER retention. IGP48 is detected by antibodies from T. b. rhodesiense infected humans. We propose that the IGPs represent a trypanosomatid-specific family of ER-localised glycoproteins, with potential contributions to life cycle progression and immunity, and utilise oligomerisation as an ER retention mechanism.

  9. Probabilistic multi-person localisation and tracking in image sequences

    Science.gov (United States)

    Klinger, T.; Rottensteiner, F.; Heipke, C.

    2017-05-01

    The localisation and tracking of persons in image sequences in commonly guided by recursive filters. Especially in a multi-object tracking environment, where mutual occlusions are inherent, the predictive model is prone to drift away from the actual target position when not taking context into account. Further, if the image-based observations are imprecise, the trajectory is prone to be updated towards a wrong position. In this work we address both these problems by using a new predictive model on the basis of Gaussian Process Regression, and by using generic object detection, as well as instance-specific classification, for refined localisation. The predictive model takes into account the motion of every tracked pedestrian in the scene and the prediction is executed with respect to the velocities of neighbouring persons. In contrast to existing methods our approach uses a Dynamic Bayesian Network in which the state vector of a recursive Bayes filter, as well as the location of the tracked object in the image, are modelled as unknowns. This allows the detection to be corrected before it is incorporated into the recursive filter. Our method is evaluated on a publicly available benchmark dataset and outperforms related methods in terms of geometric precision and tracking accuracy.

  10. On Fuzzy Ideals of BL-Algebras

    Science.gov (United States)

    Xin, Xiao Long

    2014-01-01

    In this paper we investigate further properties of fuzzy ideals of a BL-algebra. The notions of fuzzy prime ideals, fuzzy irreducible ideals, and fuzzy Gödel ideals of a BL-algebra are introduced and their several properties are investigated. We give a procedure to generate a fuzzy ideal by a fuzzy set. We prove that every fuzzy irreducible ideal is a fuzzy prime ideal but a fuzzy prime ideal may not be a fuzzy irreducible ideal and prove that a fuzzy prime ideal ω is a fuzzy irreducible ideal if and only if ω(0) = 1 and |Im⁡(ω)| = 2. We give the Krull-Stone representation theorem of fuzzy ideals in BL-algebras. Furthermore, we prove that the lattice of all fuzzy ideals of a BL-algebra is a complete distributive lattice. Finally, it is proved that every fuzzy Boolean ideal is a fuzzy Gödel ideal, but the converse implication is not true. PMID:24892085

  11. Simulations of Edge Current Driven Kink Modes with BOUT + + code

    Science.gov (United States)

    Li, G. Q.; Xu, X. Q.; Snyder, P. B.; Turnbull, A. D.; Xia, T. Y.; Ma, C. H.; Xi, P. W.

    2013-10-01

    Edge kink modes (or peeling modes) play a key role in the ELMs. The edge kink modes are driven by peak edge current, which comes from the bootstrap current. We calculated sequences of equilibria with different edge current using CORSICA by keeping total current and pressure profile fixed. Based on these equilibria, with the 3-field BOUT + + code, we calculated the MHD instabilities driven by edge current. For linear low-n ideal MHD modes, BOUT + + results agree with GATO results. With the edge current increasing, the dominant modes are changed from high-n ballooning modes to low-n kink modes. The edge current provides also stabilizing effects on high-n ballooning modes. Furthermore, for edge current scan without keeping total current fixed, the increasing edge current can stabilize the high-n ballooning modes and cannot drive kink modes. The diamagnetic effect can stabilize the high-n ballooning modes, but has no effect on the low-n kink modes. Also, the nonlinear behavior of kink modes is analyzed. Work supported by China MOST grant 2013GB111000 and by China NSF grant 10975161. Also performed for USDOE by LLNL under DE-AC52-07NA27344.

  12. The Edge supersonic transport

    Science.gov (United States)

    Agosta, Roxana; Bilbija, Dushan; Deutsch, Marc; Gallant, David; Rose, Don; Shreve, Gene; Smario, David; Suffredini, Brian

    1992-01-01

    As intercontinental business and tourism volumes continue their rapid expansion, the need to reduce travel times becomes increasingly acute. The Edge Supersonic Transport Aircraft is designed to meet this demand by the year 2015. With a maximum range of 5750 nm, a payload of 294 passengers and a cruising speed of M = 2.4, The Edge will cut current international flight durations in half, while maintaining competitive first class, business class, and economy class comfort levels. Moreover, this transport will render a minimal impact upon the environment, and will meet all Federal Aviation Administration Part 36, Stage III noise requirements. The cornerstone of The Edge's superior flight performance is its aerodynamically efficient, dual-configuration design incorporating variable-geometry wingtips. This arrangement combines the benefits of a high aspect ratio wing at takeoff and low cruising speeds with the high performance of an arrow-wing in supersonic cruise. And while the structural weight concerns relating to swinging wingtips are substantial, The Edge looks to ever-advancing material technologies to further increase its viability. Heeding well the lessons of the past, The Edge design holds economic feasibility as its primary focus. Therefore, in addition to its inherently superior aerodynamic performance, The Edge uses a lightweight, largely windowless configuration, relying on a synthetic vision system for outside viewing by both pilot and passengers. Additionally, a fly-by-light flight control system is incorporated to address aircraft supersonic cruise instability. The Edge will be produced at an estimated volume of 400 aircraft and will be offered to airlines in 2015 at $167 million per transport (1992 dollars).

  13. The ideal imaging AR waveguide

    Science.gov (United States)

    Grey, David J.

    2017-06-01

    Imaging waveguides are a key development that are helping to create the Augmented Reality revolution. They have the ability to use a small projector as an input and produce a wide field of view, large eyebox, full colour, see-through image with good contrast and resolution. WaveOptics is at the forefront of this AR technology and has developed and demonstrated an approach which is readily scalable. This paper presents our view of the ideal near-to-eye imaging AR waveguide. This will be a single-layer waveguide which can be manufactured in high volume and low cost, and is suitable for small form factor applications and all-day wear. We discuss the requirements of the waveguide for an excellent user experience. When enhanced (AR) viewing is not required, the waveguide should have at least 90% transmission, no distracting artifacts and should accommodate the user's ophthalmic prescription. When enhanced viewing is required, additionally, the waveguide requires excellent imaging performance, this includes resolution to the limit of human acuity, wide field of view, full colour, high luminance uniformity and contrast. Imaging waveguides are afocal designs and hence cannot provide ophthalmic correction. If the user requires this correction then they must wear either contact lenses, prescription spectacles or inserts. The ideal imaging waveguide would need to cope with all of these situations so we believe it must be capable of providing an eyebox at an eye relief suitable for spectacle wear which covers a significant range of population inter-pupillary distances. We describe the current status of our technology and review existing imaging waveguide technologies against the ideal component.

  14. The importance of strain localisation in shear zones

    Science.gov (United States)

    Bons, Paul D.; Finch, Melanie; Gomez-Rivas, Enrique; Griera, Albert; Llorens, Maria-Gema; Steinbach, Florian; Weikusat, Ilka

    2016-04-01

    The occurrence of various types of shear bands (C, C', C'') in shear zones indicate that heterogeneity of strain is common in strongly deformed rocks. However, the importance of strain localisation is difficult to ascertain if suitable strain markers are lacking, which is usually the case. Numerical modelling with the finite-element method has so far not given much insight in the development of shear bands. We suggest that this is not only because the modelled strains are often not high enough, but also because this technique (that usually assumes isotropic material properties within elements) does not properly incorporate mineral deformation behaviour. We simulated high-strain, simple-shear deformation in single- and polyphase materials with a full-field theory (FFT) model coupled to the Elle modelling platform (www.elle.ws; Lebensohn 2001; Bons et al. 2008). The FFT-approach simulates visco-plastic deformation by dislocation glide, taking into account the different available slip systems and their critical resolved shear stresses in relations to the applied stresses. Griera et al. (2011; 2013) have shown that this approach is particularly well suited for strongly anisotropic minerals, such as mica and ice Ih (Llorens 2015). We modelled single- and polyphase composites of minerals with different anisotropies and strengths, roughly equivalent to minerals such as ice Ih, mica, quartz and feldspar. Single-phase polycrystalline aggregates show distinct heterogeneity of strain rate, especially in case of ice Ih, which is mechanically close to mica (see also Griera et al. 2015). Finite strain distributions are heterogeneous as well, but the patterns may differ from that of the strain rate distribution. Dynamic recrystallisation, however, usually masks any strain and strain rate localisation (Llorens 2015). In case of polyphase aggregates, equivalent to e.g. a granite, we observe extensive localisation in both syn- and antithetic shear bands. The antithetic shear bands

  15. Binaural Active Audition for Humanoid Robots to Localise Speech over Entire Azimuth Range

    Directory of Open Access Journals (Sweden)

    Hyun-Don Kim

    2009-01-01

    Full Text Available We applied motion theory to robot audition to improve the inadequate performance. Motions are critical for overcoming the ambiguity and sparseness of information obtained by two microphones. To realise this, we first designed a sound source localisation system integrated with cross-power spectrum phase (CSP analysis and an EM algorithm. The CSP of sound signals obtained with only two microphones was used to localise the sound source without having to measure impulse response data. The expectation-maximisation (EM algorithm helped the system to cope with several moving sound sources and reduce localisation errors. We then proposed a way of constructing a database for moving sounds to evaluate binaural sound source localisation. We evaluated our sound localisation method using artificial moving sounds and confirmed that it could effectively localise moving sounds slower than 1.125 rad/s. Consequently, we solved the problem of distinguishing whether sounds were coming from the front or rear by rotating and/or tipping the robot's head that was equipped with only two microphones. Our system was applied to a humanoid robot called SIG2, and we confirmed its ability to localise sounds over the entire azimuth range as the success rates for sound localisation in the front and rear areas were 97.6% and 75.6% respectively.

  16. An efficient distributed localisation algorithm for wireless sensor networks: based on smart reference-selection method

    CSIR Research Space (South Africa)

    Abu-Mahfouz, Adnan M

    2013-05-01

    Full Text Available of the available references to enhance their performance. However, to implement an efficient localisation algorithm for WSNs one should reconsider this assumption. This paper introduces an efficient localisation algorithm that is based on a novel smart reference-selection...

  17. Neuroglobin in the rat brain (II): co-localisation with neurotransmitters

    DEFF Research Database (Denmark)

    Hundahl, Christian Ansgar; Kelsen, Jesper; Dewilde, Sylvia

    2008-01-01

    In an accompanying article, we found that neuroglobin (Ngb) was expressed in a few well-defined nuclei in the rat brain. Here, we show by use of immunohistochemistry and in situ hybridisation (ISH) that Ngb co-localise with several specific neurotransmitters. Ngb co-localise consistently with tyr...

  18. EdgeCentric: Anomaly Detection in Edge-Attributed Networks

    OpenAIRE

    Shah, Neil; Beutel, Alex; Hooi, Bryan; Akoglu, Leman; Gunnemann, Stephan; Makhija, Disha; Kumar, Mohit; Faloutsos, Christos

    2015-01-01

    Given a network with attributed edges, how can we identify anomalous behavior? Networks with edge attributes are commonplace in the real world. For example, edges in e-commerce networks often indicate how users rated products and services in terms of number of stars, and edges in online social and phonecall networks contain temporal information about when friendships were formed and when users communicated with each other -- in such cases, edge attributes capture information about how the adj...

  19. Localised proton magnetic resonance spectroscopy in X-linked adrenoleukodystrophy

    Energy Technology Data Exchange (ETDEWEB)

    Confort-Gouny, S. [Centre de Resonance Magnetique Biologique et Medicale (CRMBM), URA, CNRS, Faculte de Medicine, 13 - Marseille (France); Vion-Dury, J. [Centre de Resonance Magnetique Biologique et Medicale (CRMBM), URA, CNRS, Faculte de Medicine, 13 - Marseille (France); Cozzone, P.J. [Centre de Resonance Magnetique Biologique et Medicale (CRMBM), URA, CNRS, Faculte de Medicine, 13 - Marseille (France); Chabrol, B. [Service de Neuropediatrie, Hospital d`Enfants, Centre Hospitalo Universitaire, 13 - Marseille (France); Nicoli, F. [Service de Neurologie, Hopital Ste Margeurite, 13 - Marseille (France)

    1995-10-01

    We have performed localised proton magnetic resonance spectroscopy (MRS) of the brain on four patients with X-linked adrenoleukodystrophy (X-ALD). The spectrum is characterised at the beginning of the disease by a decrease in N-acetylaspartate and phosphocreatine-creatine content. Choline is strongly increased, and lactate can be detected in some cases. A proton signal from the CH{sub 2} groups borne by free intracellular very long chain fatty acids can also be observed. Later in the disease, the levels of all metabolites, in particular NAA, decrease significantly. The progression of neurometabolism documented by MRS correlates well with MRI and clinical progression on follow-up study. In one case, the metabolic profile recorded by proton MRS was abnormal before any change occurred on MRI. Proton MRS of the brain might be the method of choice for monitoring patients with X-ALD, to screen presumed cases and to study the effects of treatment. (orig.)

  20. Le kyste hydatique du cordon spermatique : une localisation exceptionnelle

    Directory of Open Access Journals (Sweden)

    Mohamed Moncef Hamdane

    2011-12-01

    Full Text Available L� hydatidose est une anthropozoonose due au developpement chez l�homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extremement rare avec seulement 4 cas rapportes dans la litterature. Les auteurs rapportent dans cet article un nouveau cas d�hydatidose du cordon spermatique. Il s�agissait d�un homme de 40 ans qui consultait pour des douleurs scrotales evoluant depuis huit mois. L�examen clinique a mis en evidence une tumefaction mobile, inguino-scrotale, droite. L�echographie testiculaire a objective une hernie inguinale droite associee a deux kystes epididymaires bilateraux. Le patient a ete opere pour cure de son hernie avec decouverte en per-operatoire d�un kyste du cordon spermatique qui a ete reseque. L�examen anatomopathologique a conclu a une hydatidose du cordon spermatique.

  1. Valutazione economica dello studio IDEAL

    Directory of Open Access Journals (Sweden)

    Enrica Menditto

    2007-10-01

    Full Text Available Introduction: the IDEAL (“High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction” study was carried out to compare intensive lowering of low-density lipoprotein (LDL-cholesterol using the highest recommended dose of atorvastatin 80 mg with simvastatin 40 mg. Aim: our aim was to investigate the economic consequence of high dose of atorvastatin vs usual-dose of simvastatin in reducing major coronary events in patients with a history of acute myocardial infarction (AMI. Methods: the analysis is based on clinical outcome data from the IDEAL study. We conducted a cost-effectiveness analysis, comparing high dose of atorvastatin (80 mg/die versus usual-dose of simvastatin (20 mg/die in the perspective of the Italian National Health Service. We identified and quantified medical costs: drug costs according to the Italian National Therapeutic Formulary and hospitalizations were quantified based on the Italian National Health Service tariffs (2006. Effects were measured in terms of mortality and morbidity reduction (number of deaths, life years gained and frequency of hospitalizations. We considered an observation period of 4.8 years. The costs borne after the first 12 months were discounted using an annual rate of 3%. We conducted one and multi-way sensitivity analyses on unit cost and effectiveness. We also conducted a threshold analysis. Results: the cost of simvastatin or atorvastatin therapy over the 4.8 years period amounted to approximately 2.3 millions euro and 2.6 millions euro per 1,000 patients respectively. Atorvastatin was more efficacious compared to simvastatin and the overall cost of care per 1,000 patients over 4.8 years of follow-up was estimated at 4.3 millions euro in the simvastatin and 4,18 millions euro in the atorvastatin group, resulting into a cost saving of 121,518 euro that is 2.8% of total costs occurred in the simvastatin group. Discussion: this study is the first economic

  2. Localisation and mechanism of renal retention of radiolabelled somatostatin analogues

    Energy Technology Data Exchange (ETDEWEB)

    Melis, Marleen; Krenning, Eric P.; Bernard, Bert F.; Jong, Marion de [Erasmus MC, Department of Nuclear Medicine, Rotterdam (Netherlands); Barone, Raffaella [UCL, Centre of Nuclear Medicine and Laboratory of PET, Brussels (Belgium); Visser, Theo J. [Erasmus MC, Department of Internal Medicine, Rotterdam (Netherlands)

    2005-10-01

    Radiolabelled somatostatin analogues, such as octreotide and octreotate, are used for tumour scintigraphy and radionuclide therapy. The kidney is the most important critical organ during such therapy owing to the reabsorption and retention of radiolabelled peptides. The aim of this study was to investigate in a rat model both the localisation and the mechanism of renal uptake after intravenous injection of radiolabelled somatostatin analogues. The multi-ligand megalin/cubilin receptor complex, responsible for reabsorption of many peptides and proteins in the kidney, is an interesting candidate for renal endocytosis of these peptide analogues. For localisation studies, ex vivo autoradiography and micro-autoradiography of rat kidneys were performed 1-24 h after injection of radiolabelled somatostatin analogues and compared with the renal anti-megalin immunohistochemical staining pattern. To confirm a role of megalin in the mechanism of renal retention of [{sup 111}In-DTPA]octreotide, the effects of three inhibitory substances were explored in rats. Renal ex vivo autoradiography showed high cortical radioactivity and lower radioactivity in the outer medulla. The distribution of cortical radioactivity was inhomogeneous. Micro-autoradiography indicated that radioactivity was only retained in the proximal tubules. The anti-megalin immunohistochemical staining pattern showed a strong similarity with the renal [{sup 111}In-DTPA]octreotide ex vivo autoradiograms. Biodistribution studies showed that co-injection of positively charged d-lysine reduced renal uptake to 60% of control. Sodium maleate reduced renal [{sup 111}In-DTPA]octreotide uptake to 15% of control. Finally, cisplatin pre-treatment of rats reduced kidney uptake to 70% of control. Renal retention of [{sup 111}In-DTPA]octreotide is confined to proximal tubules in the rat kidney, in which megalin-mediated endocytosis may play an important part. (orig.)

  3. Ethical topicality of the ideal beauty

    National Research Council Canada - National Science Library

    Simona Chiodo

    2015-01-01

    ...: by making us undergo the aesthetic experience of recognizing something ideal into something real, beauty can be the clearest symbol of our possibility, and even hope, of working on an ideal human...

  4. (Fuzzy) Ideals of BN-Algebras

    Science.gov (United States)

    Walendziak, Andrzej

    2015-01-01

    The notions of an ideal and a fuzzy ideal in BN-algebras are introduced. The properties and characterizations of them are investigated. The concepts of normal ideals and normal congruences of a BN-algebra are also studied, the properties of them are displayed, and a one-to-one correspondence between them is presented. Conditions for a fuzzy set to be a fuzzy ideal are given. The relationships between ideals and fuzzy ideals of a BN-algebra are established. The homomorphic properties of fuzzy ideals of a BN-algebra are provided. Finally, characterizations of Noetherian BN-algebras and Artinian BN-algebras via fuzzy ideals are obtained. PMID:26125050

  5. Steady non-ideal detonations

    Science.gov (United States)

    Sharpe, Gary

    2009-06-01

    Theories for determining the velocity of detonation (VoD) in highly non-ideal explosives, e.g. commercial explosives used in mining, are discussed. Such explosives have critical charge diameters of several centimetres. An analysis of the interaction between detonations and confining materials along the explosive-confiner interface reveals there a two main types of interaction. In the first (denoted here by case 1) the detonation drives an oblique shock into the confiner. For the second (case 2), a wave propagates in the confiner ahead of the detonation in the explosive. Shock polar interactions are examined for commercial explosives and rocks, which shows that a significant proportion of problems are case 2 in mining. For case 1, numerical simulations show that for a given explosive model there is a unique relationship (valid for all charge diameters and confinements) between the VoD and the curvature of the detonation shock at the charge axis. This relationship is shown to be well predicted by a quasi-one-dimensional type analysis. A simple detonation shock dynamics method which uses this relationships predicts well the VoD even in highly non-ideal cases, provided the explosive is sufficiently confined (usually the case in mining), but which is inaccurate in the limit of an unconfined charge. Preliminary results of a novel variational method for solving the unconfined situation are also discussed. Numerical simulations are performed to investigate the coupling mechanisms in case 2 situations, including the influence on diameter effects. It is shown that, in agreement with an approximate theory, the detonation is driven up to VoDs above the confiner's sound speed, and the wave in the confiner weakly pre-compresses the explosive ahead of the detonation front.

  6. Fashion dolls: representations of ideals of beauty.

    Science.gov (United States)

    Pedersen, E L; Markee, N L

    1991-08-01

    To study the ideal of beauty that fashion dolls portray, a sample of 15 dolls (one of each type available by manufacturer) was collected. In comparison with both the fashion model ideal and the Greek model of beauty the dolls were observed to be short waisted and to have longer legs than either ideal.

  7. Recharging Our Sense of Idealism: Concluding Thoughts

    Science.gov (United States)

    D'Andrea, Michael; Dollarhide, Colette T.

    2011-01-01

    In this article, the authors aim to recharge one's sense of idealism. They argue that idealism is the Vitamin C that sustains one's commitment to implementing humanistic principles and social justice practices in the work of counselors and educators. The idealism that characterizes counselors and educators who are humanistic and social justice…

  8. Qualities of Ideal Teacher Educators

    Directory of Open Access Journals (Sweden)

    Nihal Tunca

    2015-04-01

    Full Text Available Abstract Generally, the relationship between the teacher educators' qualities and the quality of teacher education has not been discussed extensively in the literature. At the same time, various studies can be found in the eastern literature examining the characteristics of faculty members at the education faculties. The effect of teacher educators over teacher candidates has not been explored, and in this sense, there is limited number of studies examining faculty members at education faculties in Turkey. Mostly employing quantitative research designs, these studies have focused on faculty members in terms of various characteristics However, which qualities that faculty members should have as a whole have not been studied. However, faculty members, as well as teachers who are a matter of debate in terms of the qualities they are supposed to have should be examined in research studies. In this context, this study aims to identify the qualities that an ideal teacher educator should have from the perspective of education faculty students as future teachers. The current research is a qualitative study in phenomenology design. The participants of the study are third and fourth year 214 pre-service teachers from the departments of Science and Technology Teaching, Pre-School Teacher Education, Classroom Teacher Education, Social Studies Teaching and Turkish Language Teaching. Criterion sampling was used for participant selection. The data gathering tool consisted of an open-ended question that would reveal the qualities that an ideal teacher educator should have based on teacher candidates’ views. Junior and senior teacher candidates’ views were asked and the data were analyzed according to content analysis approach. As a result, the qualities that an ideal teacher educator should have been gathered under five main themes including ‘professional roles and responsibilities, professional values, personal characteristics, professional ethic

  9. The Circuit Ideal of a Vector Configuration

    DEFF Research Database (Denmark)

    Jensen, Anders Nedergaard; Bogart, Tristram; Thomas, Rekha

    The circuit ideal, $\\ica$, of a configuration $\\A = \\{\\a_1, ..., \\a_n\\} \\subset \\Z^d$ is the ideal generated by the binomials ${\\x}^{\\cc^+} - {\\x}^{\\cc^-} \\in \\k[x_1, ..., x_n]$ as $\\cc = \\cc^+ - \\cc^- \\in \\Z^n$ varies over the circuits of $\\A$. This ideal is contained in the toric ideal, $\\ia......$, of $\\A$ which has numerous applications and is nontrivial to compute. Since circuits can be computed using linear algebra and the two ideals often coincide, it is worthwhile to understand when equality occurs. In this paper we study $\\ica$ in relation to $\\ia$ from various algebraic and combinatorial...... perspectives. We prove that the obstruction to equality of the ideals is the existence of certain polytopes. This result is based on a complete characterization of the standard pairs/associated primes of a monomial initial ideal of $\\ica$ and their differences from those for the corresponding toric initial...

  10. Colonoscopy and computerised tomography scan are not sufficient to localise right sided colonic lesions accurately.

    LENUS (Irish Health Repository)

    Solon, Jacqueline Gemma

    2009-11-23

    : Aim: accurate pre-operative localisation of colonic lesions is critical especially in laparoscopic colectomy where tactile localisation is absent particularly in screen-detected tumours. The study aimed to evaluate the accuracy of colonoscopy and double-contrast computerised tomography (CT) to localise lesions treated by right hemicolectomy. Method: a retrospective chart review was performed of patients treated by right hemicolectomy under the colorectal service between July 2003 and October 2006. Pre-operative tumour location determined by CT scan and colonoscopy were compared with the intra-operative and histopathologic findings. Results: of 101 patients, 73 (73%) were for adenoma or cancer, with a final diagnosis of adenocarcinoma in 59 (59%). Pre-operative localisation was inaccurate in 29% of lesions using both CT and colonoscopy. In the transverse colon colonoscopy alone was only 37.5% accurate, increasing to 62.5% when information from the CT scan was added. Conclusion: pre-operative localisation of right-sided colon cancers using colonoscopy and CT scanning is unreliable in at least 29% of cases. Inaccurate localisation of transverse colon tumours risks inadequate lymphadenectomy with an adverse cancer outcome. Pre-operative abdominal CT scan improves accuracy but endoscopic tattoo localisation should be employed routinely especially in patients undergoing laparoscopic resection.

  11. Localised boundary air layer and clothing evaporative resistances for individual body segments.

    Science.gov (United States)

    Wang, Faming; del Ferraro, Simona; Lin, Li-Yen; Sotto Mayor, Tiago; Molinaro, Vincenzo; Ribeiro, Miguel; Gao, Chuansi; Kuklane, Kalev; Holmér, Ingvar

    2012-01-01

    Evaporative resistance is an important parameter to characterise clothing thermal comfort. However, previous work has focused mainly on either total static or dynamic evaporative resistance. There is a lack of investigation of localised clothing evaporative resistance. The objective of this study was to study localised evaporative resistance using sweating thermal manikins. The individual and interaction effects of air and body movements on localised resultant evaporative resistance were examined in a strict protocol. The boundary air layer's localised evaporative resistance was investigated on nude sweating manikins at three different air velocity levels (0.18, 0.48 and 0.78 m/s) and three different walking speeds (0, 0.96 and 1.17 m/s). Similarly, localised clothing evaporative resistance was measured on sweating manikins at three different air velocities (0.13, 0.48 and 0.70 m/s) and three walking speeds (0, 0.96 and 1.17 m/s). Results showed that the wind speed has distinct effects on local body segments. In contrast, walking speed brought much more effect on the limbs, such as thigh and forearm, than on body torso, such as back and waist. In addition, the combined effect of body and air movement on localised evaporative resistance demonstrated that the walking effect has more influence on the extremities than on the torso. Therefore, localised evaporative resistance values should be provided when reporting test results in order to clearly describe clothing local moisture transfer characteristics. Localised boundary air layer and clothing evaporative resistances are essential data for clothing design and assessment of thermal comfort. A comprehensive understanding of the effects of air and body movement on localised evaporative resistance is also necessary by both textile and apparel researchers and industry.

  12. Steady Non-Ideal Detonation

    Science.gov (United States)

    Sharpe, G. J.; Luheshi, M. Y.; Braithwaite, M.; Falle, S. A. E. G.

    2009-12-01

    Highly non-ideal explosives, such as commercial ammonium nitrate based explosives used in mining and blasting, have critical charge diameters of several centimetres and relatively low detonation speeds. Shock polar match analyses between these explosives and confining inert materials give two main types of interactions. For the first type (denoted here by case I), the detonation drives an oblique shock into the confiner. For the second type (case II), a wave propagates in the confiner ahead of the detonation wave in the explosive. In case I, numerical simulations show that for a given explosive model there is a unique relationship (valid for all charge diameters and confinements) between the velocity of detonation (VoD) and the curvature of the detonation shock at the charge axis. This relationship is shown to be well predicted by a quasi-one-dimensional analysis. A simple detonation shock dynamics method which uses this relationship predicts the VoD provided the explosive is sufficiently confined (usually the case in mining), but is inaccurate in the limit of an unconfined charge. For commercial explosives confined by rocks, a significant proportion of problems are case II. Numerical simulations are performed to investigate the coupling mechanisms in these situations. It is found that, in agreement with an approximate theory, the detonation is driven up to VoDs near the confiner's sound speed, and the wave in the confiner weakly pre-compresses the explosive ahead of the detonation front.

  13. Materialised Ideals Sizes and Beauty

    Directory of Open Access Journals (Sweden)

    Kirsi Laitala

    2011-04-01

    Full Text Available Today’s clothing industry is based on a system where clothes are made in ready-to-wear sizes and meant to fit most people. Studies have pointed out that consumers are discontent with the use of these systems: size designations are not accurate enough to find clothing that fits, and different sizes are poorly available. This article discusses in depth who these consumers are, and which consumer groups are the most dissatisfied with today’s sizing systems. Results are based on a web survey where 2834 Nordic consumers responded, complemented with eight in-depth interviews, market analysis on clothing sizes and in-store trouser size measurements. Results indicate that higher shares of the consumers who have a body out of touch with the existing beauty ideals express discontentment with the sizing systems and the poor selection available. In particular, large women, very large men, and thin, short men are those who experience less priority in clothing stores and have more difficulties in finding clothes that fit. Consumers tend to blame themselves when the clothes do not fit their bodies, while our study points out that the industry is to blame as they do not produce clothing for all customers.

  14. What is the ideal crystalloid?

    Science.gov (United States)

    Raghunathan, Karthik; Nailer, Patrick; Konoske, Ryan

    2015-08-01

    We discuss the importance of the composition of intravenous crystalloid solutions. On the basis of current physiologic principles, evidence from basic science and clinical experiments, recent observational studies, and clinical trials, we conclude that the 'ideal crystalloid' depends on clinical context. We make recommendations on solutions that may be used during critical illness, major surgery, and certain clinical situations. The routine use of solutions with a supraphysiologic chloride content and a low strong ion difference (SID), such as isotonic saline solution, may be associated with adverse outcomes, especially among critically ill patients. On the contrary, solutions with a physiologic chloride content and a 'balanced' electrolyte composition (SID closer to plasma) may improve the likelihood of survival. The distribution of different types of crystalloids across traditional 'body compartments' is a function of osmolality of the fluid infused relative to plasma, integrity of the glycocalyx, and the hemodynamic/'volume' state of the patient. During critical illness, the routine administration of colloids may offer no clinical benefits compared with the use of crystalloids. Crystalloids, like other types of intravenous fluids, are drugs with important effects on clinical outcomes that may be mediated by osmolality, chloride content, and SID.

  15. Radioguided localisation of impalpable breast lesions using 99m-Technetium macroaggregated albumin: Lessons learnt during introduction of a new technique to guide preoperative localisation

    Energy Technology Data Exchange (ETDEWEB)

    Landman, Joanne [Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia); Kulawansa, Sagarika [Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia (Australia); McCarthy, Michael; Troedson, Russell [Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia); Phillips, Michael [Western Australian Institute for Medical Research, University of Western Australia, Perth, Western Australia (Australia); Tinning, Jill [The Multidisciplinary Breast Service, Royal Perth Hospital, Perth, Western Australia (Australia); Taylor, Donna, E-mail: Donna.Taylor@health.wa.gov.au [Department of Diagnostic and Interventional Radiology, Royal Perth Hospital, Perth, Western Australia (Australia); School of Surgery, University of Western Australia, Perth, Western Australia (Australia); Department of Nuclear Medicine, Royal Perth Hospital, Perth, Western Australia (Australia)

    2015-03-15

    Preoperative wire-guided localisation (WGL) of impalpable breast lesions is widely used but can be technically difficult. Risks include wire migration, inaccurate placement, and inadequate surgical margins. Research shows that radioguided occult lesion localisation (ROLL) is quicker, easier, and can improve surgical and cosmetic outcomes. An audited introduction of ROLL was conducted to validate the technique as a feasible alternative to WGL. Fifty patients with single impalpable lesions and biopsy proven malignancy or indeterminate histology underwent WGL followed by intralesional radiopharmaceutical injection of 99m-Technetium macroaggregated albumin. Postprocedural mammography was performed to demonstrate wire position, and scintigraphy to evaluate radiopharmaceutical migration. Lymphoscintigraphy and intraoperative sentinel node biopsy were performed if indicated, followed by lesion localisation and excision using a gamma probe. Specimen imaging was performed, with immediate reexcision for visibly inadequate margins. Accurate localisation was achieved in 86% of patients with ROLL compared to 72% with WGL. All lesions were successfully removed, with clear margins in 71.8% of malignant lesions. Reexcision and intraoperative sentinel node localisation rates were equivalent to preaudit figures for WGL. ROLL was easy to perform and problems were infrequent. Inaccurate radiopharmaceutical placement necessitating WGL occurred in four patients. Minor radiopharmaceutical migration was common, but precluded using ROLL in only two cases. ROLL is effective, simple, inexpensive, and easily learnt; however, preoperative confirmation of correct radiopharmaceutical placement using mammography and the gamma probe is important to help ensure successful lesion removal. Insertion of a backup hookwire is recommended during the initial introduction of ROLL.

  16. Diameter effect and detonation front curvature of ideal and non-ideal explosives

    Science.gov (United States)

    Sandstrom, F. W.; Abernathy, R. L.; Leone, M. G.; Banks, M. L.

    2000-04-01

    Diameter effect and detonation front curvature data are presented for several representative ideal and non-ideal explosives, including cast TNT, Tritonal, urea nitrate (UN), ANFO, and two variants of ammonium nitrate (AN)/solid fuel explosives. The ideal vs. non-ideal detonation characteristics of these various explosives are compared and contrasted with respect to particle size and chemical composition.

  17. Edge domination in grids

    DEFF Research Database (Denmark)

    Klostermeyer, William F.; Yeo, Anders

    2015-01-01

    It has been conjectured that the edge domination number of the m × n grid graph, denoted by γ′(Pm□Pn), is ⌊mn/3⌋, when m,n ≥ 2. Our main result gives support for this conjecture by proving that ⌊mn/3⌋ ≤ -γ′{Pm□Pn) ≤ mn/3 + n/12 + 1, when m,n ≥ 2. We furthermore show that the conjecture holds when...

  18. Off the edge

    OpenAIRE

    Stoneham, Luke

    2014-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel University London. Work which takes from elsewhere forms an important thread in European art music. There is a long tradition of music which variously borrows, thieves, pastiches, plagiarises, ironically ‘retakes’, hoaxes, impersonates and appropriates. The music I have written for Off the edge, while seeking to honour and add to this thread, also attempts to zoom in upon and make explicit the idea o...

  19. Anderson localisation and optical-event horizons in rogue-soliton generation

    CERN Document Server

    Saleh, Mohammed F; Biancalana, Fabio

    2016-01-01

    We show that the true origin of rogue solitons in optical fibres is due to the combined action of linear Anderson localisation and the formation of optical-event horizons. Anderson localised modes are formed in certain temporal locations due to the random background noise. Such localised modes seed the formation of solitary waves at those preferred locations, while the strongest Anderson mode generates the rogue soliton. The event horizon effect between dispersive waves and solitons produces an artificial collective acceleration that favours the collision of solitons during the rogue wave formation.

  20. Optimal localisation of next generation Biofuel production in Sweden

    Energy Technology Data Exchange (ETDEWEB)

    Wetterlund, Elisabeth [Linkoeping Univ., Linkoeping (Sweden); Pettersson, Karin [Chalmers Univ. of Technology, Goeteborg (Sweden); Mossberg, Johanna [SP Technical Research Inst. of Sweden, Boraas (Sweden)] [and others

    2013-09-01

    With a high availability of lignocellulosic biomass and various types of cellulosic by-products, as well as a large number of industries, Sweden is a country of great interest for future large scale production of sustainable, next generation biofuels. This is most likely also a necessity as Sweden has the ambition to be independent of fossil fuels in the transport sector by the year 2030 and completely fossil free by 2050. In order to reach competitive biofuel production costs, plants with large production capacities are likely to be required. Feedstock intake capacities in the range of about 1-2 million tonnes per year, corresponding to a biomass feed of 300-600 MW, can be expected, which may lead to major logistical challenges. To enable expansion of biofuel production in such large plants, as well as provide for associated distribution requirements, it is clear that substantial infrastructure planning will be needed. The geographical location of the production plant facilities is therefore of crucial importance and must be strategic to minimise the transports of raw material as well as of final product. Competition for the available feedstock, from for example forest industries and CHP plants (combined heat and power) further complicates the localisation problem. Since the potential for an increased biomass utilisation is limited, high overall resource efficiency is of great importance. Integration of biofuel production processes in existing industries or in district heating systems may be beneficial from several aspects, such as opportunities for efficient heat integration, feedstock and equipment integration, as well as access to existing experience and know-how. This report describes the development of Be Where Sweden, a geographically explicit optimisation model for localisation of next generation biofuel production plants in Sweden. The main objective of developing such a model is to be able to assess production plant locations that are robust to varying

  1. Comparison of real and idealized cetacean flippers.

    Science.gov (United States)

    Weber, P W; Murray, M M; Howle, L E; Fish, F E

    2009-12-01

    When a phenomenon in nature is mimicked for practical applications, it is often done so in an idealized fashion, such as representing the shape found in nature with convenient, piece-wise smooth mathematical functions. The aim of idealization is to capture the advantageous features of the natural phenomenon without having to exactly replicate it, and it is often assumed that the idealization process does in fact capture the relevant geometry. We explored the consequences of the idealization process by creating exact scale models of cetacean flippers using CT scans, creating corresponding idealized versions and then determining the hydrodynamic characteristics of the models via water tunnel testing. We found that the majority of the idealized models did not exhibit fluid dynamic properties that were drastically different from those of the real models, although multiple consequences resulting from the idealization process were evident. Drag performance was significantly improved by idealization. Overall, idealization is an excellent way to capture the relevant effects of a phenomenon found in nature, which spares the researcher from having to painstakingly create exact models, although we have found that there are situations where idealization may have unintended consequences such as one model that exhibited a decrease in lift performance.

  2. Comparison of real and idealized cetacean flippers

    Energy Technology Data Exchange (ETDEWEB)

    Weber, P W; Howle, L E [Department of Mechanical Engineering and Materials Science, Duke University, Box 90300, Durham, NC 27708 (United States); Murray, M M [Department of Mechanical Engineering, United States Naval Academy, 590 Holloway Road, Annapolis, MD 21402 (United States); Fish, F E, E-mail: laurens.howle@duke.ed [Department of Biology, West Chester University, 750 S Church Street, West Chester, PA 19383 (United States)

    2009-12-15

    When a phenomenon in nature is mimicked for practical applications, it is often done so in an idealized fashion, such as representing the shape found in nature with convenient, piece-wise smooth mathematical functions. The aim of idealization is to capture the advantageous features of the natural phenomenon without having to exactly replicate it, and it is often assumed that the idealization process does in fact capture the relevant geometry. We explored the consequences of the idealization process by creating exact scale models of cetacean flippers using CT scans, creating corresponding idealized versions and then determining the hydrodynamic characteristics of the models via water tunnel testing. We found that the majority of the idealized models did not exhibit fluid dynamic properties that were drastically different from those of the real models, although multiple consequences resulting from the idealization process were evident. Drag performance was significantly improved by idealization. Overall, idealization is an excellent way to capture the relevant effects of a phenomenon found in nature, which spares the researcher from having to painstakingly create exact models, although we have found that there are situations where idealization may have unintended consequences such as one model that exhibited a decrease in lift performance.

  3. Not All Ideals are Equal: Intrinsic and Extrinsic Ideals in Relationships

    OpenAIRE

    Rodriguez, Lindsey M.; Hadden, Benjamin W.; Knee, C. Raymond

    2015-01-01

    The ideal standards model suggests that greater consistency between ideal standards and actual perceptions of one’s relationship predicts positive relationship evaluations; however, no research has evaluated whether this differs across types of ideals. A self-determination theory perspective was derived to test whether satisfaction of intrinsic ideals buffers the importance of extrinsic ideals. Participants (N=195) in committed relationships directly and indirectly reported the extent to whic...

  4. Edge Relaxation and Boundary Continuity.

    Science.gov (United States)

    1980-05-01

    V. Measures of Performance 94 1. Fixed Points, Entropy , and Consistency 94 2. Global Measures of Uncertainty, Drift, and Inconsistency 96 VI...operators have been applied. Marr EMARR763 uses a set of edge detectors of varying size to determine the appropriate width of an edge to be asserted in his...certain edges is a fixed point. The array of probabilities has zero entropy when the probability of each edge in the array is 0 or 1. The closed-loop

  5. Antenna array geometry optimization for a passive coherent localisation system

    Science.gov (United States)

    Knott, Peter; Kuschel, Heiner; O'Hagan, Daniel

    2012-11-01

    Passive Coherent Localisation (PCL), also known as Passive Radar, making use of RF sources of opportunity such as Radio or TV Broadcasting Stations, Cellular Phone Network Base Stations, etc. is an advancing technology for covert operation because no active radar transmitter is required. It is also an attractive addition to existing active radar stations because it has the potential to discover low-flying and low-observable targets. The CORA (Covert Radar) experimental passive radar system currently developed at Fraunhofer-FHR features a multi-channel digital radar receiver and a circular antenna array with separate elements for the VHF- and the UHF-range and is used to exploit alternatively Digital Audio (DAB) or Video Broadcasting (DVB-T) signals. For an extension of the system, a wideband antenna array is being designed for which a new discone antenna element has been developed covering the full DVB-T frequency range. The present paper describes the outline of the system and the numerical modelling and optimisation methods applied to solve the complex task of antenna array design: Electromagnetic full wave analysis is required for the parametric design of the antenna elements while combinatorial optimization methods are applied to find the best array positions and excitation coefficients for a regular omni-directional antenna performance. The different steps are combined in an iterative loop until the optimum array layout is found. Simulation and experimental results for the current system will be shown.

  6. Radical treatment of localised prostate cancer in the elderly.

    Science.gov (United States)

    Everaerts, Wouter; Van Rij, Simon; Reeves, Fairleigh; Costello, Anthony

    2015-12-01

    Elderly men are more likely to be diagnosed with aggressive cancer, but are often inappropriately denied curative treatment. Biological rather than chronological age should be used to decide if a patient will profit from radical treatment. Therefore, every man aged >70 years should undergo a health assessment using a validated tool before making treatment decisions. Fit elderly men with intermediate- or high-risk disease should be offered standard curative local treatment in keeping with guidelines for younger men. Vulnerable and frail elderly men warrant geriatric intervention before treatment. In the case of vulnerable patients, this intervention may render them suitable for standard care. When considering radical prostatectomy outcomes a 'bifecta' of oncological control and continence is appropriate, as erectile dysfunction (although prevalent) has a much smaller impact on quality of life than in younger patients. Radiotherapy is an alternative to radical prostatectomy in men with a life expectancy of <10 years. Primary androgen-deprivation therapy is not associated with improved survival in localised prostate cancer and should only be used for symptom palliation. Further elderly-specific research is needed to guide prostate cancer care. © 2015 The Authors. BJU International © 2015 BJU International.

  7. Localised cutaneous microvascular adaptation to exercise training in humans.

    Science.gov (United States)

    Atkinson, Ceri L; Carter, Howard H; Thijssen, Dick H J; Birk, Gurpreet K; Cable, N Timothy; Low, David A; Kerstens, Floortje; Meeuwis, Iris; Dawson, Ellen A; Green, Daniel J

    2018-02-07

    Exercise training induces adaptation in conduit and resistance arteries in humans, partly as a consequence of repeated elevation in blood flow and shear stress. The stimuli associated with intrinsic cutaneous microvascular adaptation to exercise training have been less comprehensively studied. We studied 14 subjects who completed 8-weeks cycle ergometer training, with partial cuff inflation on one forearm to unilaterally attenuate cutaneous blood flow responses during each exercise-training bout. Before and after training, bilateral forearm skin microvascular dilation was determined using cutaneous vascular conductance (CVC: skin flux/blood pressure) responses to gradual localised heater disk stimulation performed at rest (33, 40, 42 and 44 °C). Cycle exercise induced significant increases in forearm cutaneous flux and temperature, which were attenuated in the cuffed arm (2-way ANOVA interaction-effect; P < 0.01). We found that forearm CVC at 42 and 44 °C was significantly lower in the uncuffed arm following 8-weeks of cycle training (P < 0.01), whereas no changes were apparent in the contralateral cuffed arm (P = 0.77, interaction-effect P = 0.01). Lower limb exercise training in healthy young men leads to lower CVC-responses to a local heating stimulus, an adaptation mediated, at least partly, by a mechanism related to episodic increases in skin blood flow and/or skin temperature.

  8. The importance of FMDV localisation in lymphoid tissue.

    Science.gov (United States)

    Juleff, N D; Maree, F F; Waters, R; Bengis, R G; Charleston, B

    2012-07-15

    Foot-and-mouth disease virus, a highly contagious pathogen that can cause lameness, low weight and decreased milk production, is a scourge of agricultural livestock around the world. Although the acute phase of infection is rarely fatal, infection may persist in animals that have apparently recovered, creating a viral reservoir that some fear could contribute to the spread of disease. We have used an array of molecular techniques to search for traces of virus in tissues from the mouths and throats of infected cattle. In a carefully controlled study, we have found evidence of intact, non-replicating virus particles trapped by follicular dendritic cells within the germinal centres of lymph nodes. Strikingly, virus was present for up to 38 days post infection, even though it was undetectable in surrounding tissues. The retention of intact virus within germinal centres is likely to have a role in stimulating the long lasting immune response that is characteristic of viral infections. Our data suggests that this capture may also be responsible for preserving intact viruses capable of infecting susceptible cells as they come into contact with germinal centres. African buffalo (Syncerus caffer) are typically infected with all three South African Territories types of FMDV by 2 years of age and these viruses can be transmitted to farmed livestock. Buffalo harbour persistent virus in greater amounts and for longer periods than cattle and thus provided us with further opportunities to define the sites of viral localisation. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Plasmons on the edge of MoS2 nanostructures

    DEFF Research Database (Denmark)

    Andersen, Kirsten; Jacobsen, Karsten Wedel; Thygesen, Kristian Sommer

    2014-01-01

    Using ab initio calculations we predict the existence of one-dimensional (1D), atomically confined plasmons at the edges of a zigzag MoS2 nanoribbon. The strongest plasmon originates from a metallic edge state localized on the sulfur dimers decorating the Mo edge of the ribbon. A detailed analysis...... of the dielectric function reveals that the observed deviations from the ideal 1D plasmon behavior result from single-particle transitions between the metallic edge state and the valence and conduction bands of the MoS2 sheet. The Mo and S edges of the ribbon are clearly distinguishable in calculated spatially...... resolved electron energy loss spectrum owing to the different plasmonic properties of the two edges. The edge plasmons could potentially be utilized for tuning the photocatalytic activity of MoS2 nanoparticles....

  10. Pairs Of Edges As Chords And As Cut-Edges

    Directory of Open Access Journals (Sweden)

    McKee Terry A.

    2014-11-01

    Full Text Available Several authors have studied the graphs for which every edge is a chord of a cycle; among 2-connected graphs, one characterization is that the deletion of one vertex never creates a cut-edge. Two new results: among 3-connected graphs with minimum degree at least 4, every two adjacent edges are chords of a common cycle if and only if deleting two vertices never creates two adjacent cut-edges; among 4-connected graphs, every two edges are always chords of a common cycle.

  11. Improved Classification of Mammograms Following Idealized Training

    Science.gov (United States)

    Hornsby, Adam N.; Love, Bradley C.

    2014-01-01

    People often make decisions by stochastically retrieving a small set of relevant memories. This limited retrieval implies that human performance can be improved by training on idealized category distributions (Giguère & Love, 2013). Here, we evaluate whether the benefits of idealized training extend to categorization of real-world stimuli, namely classifying mammograms as normal or tumorous. Participants in the idealized condition were trained exclusively on items that, according to a norming study, were relatively unambiguous. Participants in the actual condition were trained on a representative range of items. Despite being exclusively trained on easy items, idealized-condition participants were more accurate than those in the actual condition when tested on a range of item types. However, idealized participants experienced difficulties when test items were very dissimilar from training cases. The benefits of idealization, attributable to reducing noise arising from cognitive limitations in memory retrieval, suggest ways to improve real-world decision making. PMID:24955325

  12. Masculinity Ideals in a Contemporary Danish Context

    DEFF Research Database (Denmark)

    Bloksgaard, Lotte; Christensen, Ann Dorte; Jensen, Sune Qvotrup

    2015-01-01

    occupations in the survey constitute a critical case, based on the argument that if traditional masculinity ideals are rejected here—among lower-educated men, who are likely to be more supportive of traditional gender ideals than the more highly educated—then Danish men in general are likely to reject...... traditional masculinity ideals. Both the quantitative and qualitative analyses indicate that traditional patriarchal masculinity ideals are not the most legitimate among the men. They seem to subscribe to more gender equality friendly masculinities, although this picture is not clear-cut as we also see...... negotiations and variations between the men. Thus, the article concludes that in a Danish context we can identify authoritative masculinity ideals that do not reproduce patriarchy or support traditional masculinity ideals in an unambiguous way....

  13. Predicting Film Genres with Implicit Ideals

    OpenAIRE

    Olney, Andrew McGregor

    2013-01-01

    We present a new approach to defining film genre based on implicit ideals. When viewers rate the likability of a film, they indirectly express their ideal of what a film should be. Across six studies we investigate the category structure that emerges from likability ratings and the category structure that emerges from the features of film. We further compare these data-driven category structures with human annotated film genres. We conclude that film genres are structured more around ideals t...

  14. In vivo fluorescence kinetics and localisation of aluminium phthalocyanine disulphonate in an autologous tumour model

    NARCIS (Netherlands)

    Witjes, MJH; Speelman, OC; Nikkels, PGJ; Nooren, CAAM; Nauta, JM; vanderHolt, B; vanLeengoed, HLLM; Roodenburg, JLN

    Sulphonated phthalocyanines are studied as photosensitisers for photodynamic therapy of cancer. Their strong fluorescence and tumour-localising properties make them also potentially useful for detection of cancer by fluorescence. For this purpose, we have studied the fluorescence kinetics and

  15. Approach to sensor node calibration for efficient localisation in wireless sensor networks in realistic scenarios

    CSIR Research Space (South Africa)

    Mwila, MK

    2014-06-01

    Full Text Available propagation basic mechanisms is a fundamental step toward the design of ranging and localisation algorithms able to work properly in realistic scenarios. Furthermore, positioning systems are migrating towards hybridisation where data coming from heterogeneous...

  16. Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.

    Science.gov (United States)

    Ruane, Peter T; Gumy, Laura F; Bola, Becky; Anderson, Beverley; Wozniak, Marcin J; Hoogenraad, Casper C; Allan, Victoria J

    2016-06-07

    Microtubules and their associated proteins (MAPs) underpin the polarity of specialised cells. Adenomatous polyposis coli (APC) is one such MAP with a multifunctional agenda that requires precise intracellular localisations. Although APC has been found to associate with kinesin-2 subfamily members, the exact mechanism for the peripheral localization of APC remains unclear. Here we show that the heavy chain of kinesin-1 directly interacts with the APC C-terminus, contributing to the peripheral localisation of APC in fibroblasts. In rat hippocampal neurons the kinesin-1 binding domain of APC is required for its axon tip enrichment. Moreover, we demonstrate that APC requires interactions with both kinesin-2 and kinesin-1 for this localisation. Underlining the importance of the kinesin-1 association, neurons expressing APC lacking kinesin-1-binding domain have shorter axons. The identification of this novel kinesin-1-APC interaction highlights the complexity and significance of APC localisation in neurons.

  17. Impact Damage Localisation with Piezoelectric Sensors under Operational and Environmental Conditions

    National Research Council Canada - National Science Library

    Mohammad Saleh Salmanpour; Zahra Sharif Khodaei; M H Ferri Aliabadi

    2017-01-01

    Guided-wave structural health monitoring (SHM) systems with piezoelectric sensors are investigated for localisation of barely visible impact damage in CFRP plates under vibration and different thermal conditions...

  18. Primary treatments for clinically localised prostate cancer: a comprehensive lifetime cost‐utility analysis

    National Research Council Canada - National Science Library

    Cooperberg, Matthew R; Ramakrishna, Naren R; Duff, Steven B; Hughes, Kathleen E; Sadownik, Sara; Smith, Joseph A; Tewari, Ashutosh K

    2013-01-01

    .... The present study is the most comprehensive cost-effectiveness analysis to date for localised prostate cancer, conducted with a lifetime horizon and accounting for survival, health-related quality...

  19. Ideal MHD Stability Prediction and Required Power for EAST Advanced Scenario

    Science.gov (United States)

    Chen, Junjie; Li, Guoqiang; Qian, Jinping; Liu, Zixi

    2012-11-01

    The Experimental Advanced Superconducting Tokamak (EAST) is the first fully superconducting tokamak with a D-shaped cross-sectional plasma presently in operation. The ideal magnetohydrodynamic (MHD) stability and required power for the EAST advanced tokamak (AT) scenario with negative central shear and double transport barrier (DTB) are investigated. With the equilibrium code TOQ and stability code GATO, the ideal MHD stability is analyzed. It is shown that a moderate ratio of edge transport barriers' (ETB) height to internal transport barriers' (ITBs) height is beneficial to ideal MHD stability. The normalized beta βN limit is about 2.20 (without wall) and 3.70 (with ideal wall). With the scaling law of energy confinement time, the required heating power for EAST AT scenario is calculated. The total heating power Pt increases as the toroidal magnetic field BT or the normalized beta βN is increased.

  20. In planta localisation patterns of MADS domain proteins during floral development in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Kaufmann Kerstin

    2009-01-01

    Full Text Available Abstract Background MADS domain transcription factors play important roles in various developmental processes in flowering plants. Members of this family play a prominent role in the transition to flowering and the specification of floral organ identity. Several studies reported mRNA expression patterns of the genes encoding these MADS domain proteins, however, these studies do not provide the necessary information on the temporal and spatial localisation of the proteins. We have made GREEN FLUORESCENT PROTEIN (GFP translational fusions with the four MADS domain proteins SEPALLATA3, AGAMOUS, FRUITFULL and APETALA1 from the model plant Arabidopsis thaliana and analysed the protein localisation patterns in living plant tissues by confocal laser scanning microscopy (CLSM. Results We unravelled the protein localisation patterns of the four MADS domain proteins at a cellular and subcellular level in inflorescence and floral meristems, during development of the early flower bud stages, and during further differentiation of the floral organs. The protein localisation patterns revealed a few deviations from known mRNA expression patterns, suggesting a non-cell autonomous action of these factors or alternative control mechanisms. In addition, we observed a change in the subcellular localisation of SEPALLATA3 from a predominantly nuclear localisation to a more cytoplasmic localisation, occurring specifically during petal and stamen development. Furthermore, we show that the down-regulation of the homeodomain transcription factor WUSCHEL in ovular tissues is preceded by the occurrence of both AGAMOUS and SEPALLATA3 proteins, supporting the hypothesis that both proteins together suppress WUSCHEL expression in the ovule. Conclusion This approach provides a highly detailed in situ map of MADS domain protein presence during early and later stages of floral development. The subcellular localisation of the transcription factors in the cytoplasm, as observed at

  1. Not All Ideals are Equal: Intrinsic and Extrinsic Ideals in Relationships.

    Science.gov (United States)

    Rodriguez, Lindsey M; Hadden, Benjamin W; Knee, C Raymond

    2015-03-01

    The ideal standards model suggests that greater consistency between ideal standards and actual perceptions of one's relationship predicts positive relationship evaluations; however, no research has evaluated whether this differs across types of ideals. A self-determination theory perspective was derived to test whether satisfaction of intrinsic ideals buffers the importance of extrinsic ideals. Participants (N=195) in committed relationships directly and indirectly reported the extent to which their partner met their ideal on two dimensions: intrinsic (e.g., warm, intimate) and extrinsic (e.g., attractive, successful). Relationship need fulfillment and relationship quality were also assessed. Hypotheses were largely supported, such that satisfaction of intrinsic ideals more strongly predicted relationship functioning, and satisfaction of intrinsic ideals buffered the relevance of extrinsic ideals for outcomes.

  2. Indoor Localisation Using a Context-Aware Dynamic Position Tracking Model

    Directory of Open Access Journals (Sweden)

    Montserrat Ros

    2012-01-01

    Full Text Available Indoor wireless localisation is a widely sought feature for use in logistics, health, and social networking applications. Low-powered localisation will become important for the next generation of pervasive media applications that operate on mobile platforms. We present an inexpensive and robust context-aware tracking system that can track the position of users in an indoor environment, using a wireless smart meter network. Our context-aware tracking system combines wireless trilateration with a dynamic position tracking model and a probability density map to estimate indoor positions. The localisation network consisted of power meter nodes placed at known positions in a building. The power meter nodes are tracked by mobile nodes which are carried by users to localise their position. We conducted an extensive trial of the context-aware tracking system and performed a comparison analysis with existing localisation techniques. The context-aware tracking system was able to localise a person's indoor position with an average error of 1.21 m.

  3. Expression and localisation of alphav integrins in human odontoblasts.

    Science.gov (United States)

    Staquet, M-J; Couble, M-L; Roméas, A; Connolly, M; Magloire, H; Hynes, R O; Clezardin, P; Bleicher, F; Farges, J-C

    2006-03-01

    Integrin alphabeta heterodimers mediate adhesion to the extracellular matrix and at cell-cell contacts and initiate intracellular signalling cascades in response to a variety of inductive factors. Apart from the expression of alphavbeta3 that we have previously reported, little is known about the expression of integrins in odontoblasts. Here, we investigated the expression of alphav-binding beta integrin subunits in healthy human dental pulp in vivo and in odontoblasts differentiated in vitro. Reverse transcription/polymerase chain reaction analysis revealed the expression of alphav, beta1, beta5 and beta8 integrin mRNA, but not beta6, in whole pulp cells. Flow cytometry showed that the alphav and beta1 subunits were the most intensely expressed. Immunohistochemistry demonstrated that the beta1 subunit was localised in newly differentiated odontoblasts in the root and in mature odontoblasts in the crown, including their intradentinal cell processes. The alphav chain was predominantly expressed by mature odontoblasts and alphavbeta5 was only observed in mature odontoblasts. In vitro differentiated odontoblasts expressed genes for alphav, beta1 and beta5, but not for beta6 and beta8. A comparison of integrin profiles between cultured pulp cells and in vitro differentiated odontoblasts revealed that odontoblast maturation was characterised by a significant increase in the expression of alphav and beta1 subunits and alphavbeta5 integrin. The beta8 subunit was detected in nerve cells only. Histological analysis of teeth from alphav knockout mice showed no obvious structural modification in the odontoblast layer. Thus, human mature odontoblasts express alphavbeta3, alphavbeta5 and perhaps alphavbeta1 integrins, with the possible presence of alpha-beta1 pairs. The roles that these molecules play in the exchange of information throughout the odontoblast layer remain to be determined.

  4. Toric ideals and diagonal 2-minors

    NARCIS (Netherlands)

    A. Katsampekis (Anargyros)

    2013-01-01

    htmlabstractLet $G$ be a simple graph on the vertex set ${1,\\ldots,n}$. An algebraic object attached to $G$ is the ideal $P_G$ generated by diagonal 2-minors of an $n \\times n$ matrix of variables. In this paper we first provide some general results concerning the ideal $P_G$. It is also proved that

  5. Extremely strict ideals in Banach spaces

    Indian Academy of Sciences (India)

    their fourth dual. Keywords. Extremely strict ideals; spaces of operators; injective tensor products. 2000 Mathematics Subject Classification. Primary: 46B20; Secondary: 47L05,. 46E40. 1. Introduction. Let X be a Banach space. We recall from [5] that a closed subspace Y ⊂ X is said to be an ideal, if there is a linear projection ...

  6. Ideal and Nonideal Reasoning in Educational Theory

    Science.gov (United States)

    Jaggar, Alison M.

    2015-01-01

    The terms "ideal theory" and "nonideal theory" are used in contemporary Anglophone political philosophy to identify alternative methodological approaches for justifying normative claims. Each term is used in multiple ways. In this article Alison M. Jaggar disentangles several versions of ideal and nonideal theory with a view to…

  7. Maintaining ideal body weight counseling sessions

    Energy Technology Data Exchange (ETDEWEB)

    Brammer, S.H.

    1980-10-09

    The purpose of this program is to provide employees with the motivation, knowledge and skills necessary to maintain ideal body weight throughout life. The target audience for this program, which is conducted in an industrial setting, is the employee 40 years of age or younger who is at or near his/her ideal body weight.

  8. Extremely strict ideals in Banach spaces

    Indian Academy of Sciences (India)

    Home; Journals; Proceedings – Mathematical Sciences; Volume 126; Issue 3 ... ({\\it Studia Math.} {\\bf 104} (1993) 13–59), in this article, we introduce and study the notion of an extremely strict ideal. For a Poulsen simplex K , we show that the space of affine continuous functions on K is an extremely strict ideal in the space of ...

  9. Improved reconstruction for IDEAL spiral CSI

    DEFF Research Database (Denmark)

    Hansen, Rie Beck; Mariager, Christian; Laustsen, Christoffer

    In this study we demonstrate how reconstruction for IDEAL spiral CSI (spectroscopic imaging scheme developed for hyperpolarized dynamic metabolic MR imaging) can be improved by using regularization with a sparsity constraint. By exploiting sparsity of the spectral domain, IDEAL spiral CSI can...

  10. Improved reconstruction for IDEAL spiral CSI

    DEFF Research Database (Denmark)

    Hansen, Rie Beck; Mariager, Christian; Laustsen, Christoffer

    2017-01-01

    In this study we demonstrate how reconstruction for IDEAL spiral CSI (spectroscopic imaging scheme developed for hyperpolarized dynamic metabolic MR imaging) can be improved by using regularization with a sparsity constraint. By exploiting sparsity of the spectral domain, IDEAL spiral CSI can...

  11. Gravity, Cartan geometry, and idealized waywisers

    CERN Document Server

    Westman, H F

    2012-01-01

    The primary aim of this paper is to provide a simple and concrete interpretation of Cartan geometry by pointing out that it is nothing but the mathematics of idealized waywisers. Waywisers, also called hodometers, are instruments traditionally used to measure distances. The mathematical representation of an idealized waywiser consists of a choice of symmetric space called a {\\em model space} and represents the `wheel' of the idealized waywiser. The geometry of a manifold is then completely characterized by a pair of variables $\\{V^A(x),A^{AB}(x)\\}$, each of which admit simple interpretations: $V^A$ is the point of contact between the waywiser's idealized wheel and the manifold whose geometry one wishes to characterize, and $A^{AB}=A_\\mu^{\\ AB}dx^\\mu$ is a connection one-form dictating how much the idealized wheel of the waywiser has rotated when rolled along the manifold. The familiar objects from differential geometry (e.g. metric $g_{\\mu\

  12. Edge-on!

    Science.gov (United States)

    2007-08-01

    Peering at Uranus's Rings as they Swing Edge-on to Earth for the First Time Since their Discovery in 1977 As Uranus coasts through a brief window of time when its rings are edge-on to Earth - a view of the planet we get only once every 42 years - astronomers peering at the rings with ESO's Very Large Telescope and other space or ground-based telescopes are getting an unprecedented view of the fine dust in the system, free from the glare of the bright rocky rings. They may even find a new moon or two. ESO PR Photo 37/07 ESO PR Photo 37/07 The Uranus System "ESO's VLT took data at the precise moment when the rings were edge-on to Earth," said Imke de Pater, of University of California, Berkeley who coordinated the worldwide campaign. She worked with two team members observing in Chile: Daphne Stam of the Technical University Delft in the Netherlands and Markus Hartung of ESO. The observations were done with NACO, one of the adaptive optics instruments installed at the VLT. With adaptive optics, it is possible to obtain images almost free from the blurring effect of the atmosphere. It is as if the 8.2-m telescope were observing from space. Observations were also done with the Keck telescope in Hawaii, the Hubble Space Telescope, and at the Palomar Observatory. "Using different telescopes around the world allows us to observe as much of the changes during the ring-plane crossing as possible: when Uranus sets as seen from the VLT, it can still be observed by the Keck," emphasised Stam. Uranus orbits the Sun in 84 years. Twice during a Uranian year, the rings appear edge-on to Earth for a brief period. The rings were discovered in 1977, so this is the first time for a Uranus ring-crossing to be observed from Earth. The advantage of observations at a ring-plane crossing is that it becomes possible to look at the rings from the shadowed or dark side. From that vantage point, the normally bright outer rings grow fainter because their centimetre- to metre-sized rocks obscure

  13. Cheating on the edge.

    Directory of Open Access Journals (Sweden)

    Lee Alan Dugatkin

    2008-07-01

    Full Text Available We present the results of an individual agent-based model of antibiotic resistance in bacteria. Our model examines antibiotic resistance when two strategies exist: "producers"--who secrete a substance that breaks down antibiotics--and nonproducers ("cheats" who do not secrete, or carry the machinery associated with secretion. The model allows for populations of up to 10,000, in which bacteria are affected by their nearest neighbors, and we assume cheaters die when there are no producers in their neighborhood. Each of 10,000 slots on our grid (a torus could be occupied by a producer or a nonproducer, or could (temporarily be unoccupied. The most surprising and dramatic result we uncovered is that when producers and nonproducers coexist at equilibrium, nonproducers are almost always found on the edges of clusters of producers.

  14. Edge remap for solids

    Energy Technology Data Exchange (ETDEWEB)

    Kamm, James R.; Love, Edward; Robinson, Allen C; Young, Joseph G.; Ridzal, Denis

    2013-12-01

    We review the edge element formulation for describing the kinematics of hyperelastic solids. This approach is used to frame the problem of remapping the inverse deformation gradient for Arbitrary Lagrangian-Eulerian (ALE) simulations of solid dynamics. For hyperelastic materials, the stress state is completely determined by the deformation gradient, so remapping this quantity effectively updates the stress state of the material. A method, inspired by the constrained transport remap in electromagnetics, is reviewed, according to which the zero-curl constraint on the inverse deformation gradient is implicitly satisfied. Open issues related to the accuracy of this approach are identified. An optimization-based approach is implemented to enforce positivity of the determinant of the deformation gradient. The efficacy of this approach is illustrated with numerical examples.

  15. Centrosomal localisation of the cancer/testis (CT antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells.

    Directory of Open Access Journals (Sweden)

    Anna Pagotto

    Full Text Available The Cancer/Testis (CT antigen family of genes are transcriptionally repressed in most human tissues but are atypically re-expressed in many malignant tumour types. Their restricted expression profile makes CT antigens ideal targets for cancer immunotherapy. As little is known about whether CT antigens may be regulated by post-translational processing, we investigated the mechanisms governing degradation of NY-ESO-1 and MAGE-C1 in selected cancer cell lines. Inhibitors of proteasome-mediated degradation induced the partitioning of NY-ESO-1 and MAGE-C1 into a detergent insoluble fraction. Moreover, this treatment also resulted in increased localisation of NY-ESO-1 and MAGE-C1 at the centrosome. Despite their interaction, relocation of either NY-ESO-1 or MAGE-C1 to the centrosome could occur independently of each other. Using a series of truncated fragments, the regions corresponding to NY-ESO-1(91-150 and MAGE-C1(900-1116 were established as important for controlling both stability and localisation of these CT antigens. Our findings demonstrate that the steady state levels of NY-ESO-1 and MAGE-C1 are regulated by proteasomal degradation and that both behave as aggregation-prone proteins upon accumulation. With proteasome inhibitors being increasingly used as front-line treatment in cancer, these data raise issues about CT antigen processing for antigenic presentation and therefore immunogenicity in cancer patients.

  16. Centrosomal localisation of the cancer/testis (CT) antigens NY-ESO-1 and MAGE-C1 is regulated by proteasome activity in tumour cells.

    Science.gov (United States)

    Pagotto, Anna; Caballero, Otavia L; Volkmar, Norbert; Devalle, Sylvie; Simpson, Andrew J G; Lu, Xin; Christianson, John C

    2013-01-01

    The Cancer/Testis (CT) antigen family of genes are transcriptionally repressed in most human tissues but are atypically re-expressed in many malignant tumour types. Their restricted expression profile makes CT antigens ideal targets for cancer immunotherapy. As little is known about whether CT antigens may be regulated by post-translational processing, we investigated the mechanisms governing degradation of NY-ESO-1 and MAGE-C1 in selected cancer cell lines. Inhibitors of proteasome-mediated degradation induced the partitioning of NY-ESO-1 and MAGE-C1 into a detergent insoluble fraction. Moreover, this treatment also resulted in increased localisation of NY-ESO-1 and MAGE-C1 at the centrosome. Despite their interaction, relocation of either NY-ESO-1 or MAGE-C1 to the centrosome could occur independently of each other. Using a series of truncated fragments, the regions corresponding to NY-ESO-1(91-150) and MAGE-C1(900-1116) were established as important for controlling both stability and localisation of these CT antigens. Our findings demonstrate that the steady state levels of NY-ESO-1 and MAGE-C1 are regulated by proteasomal degradation and that both behave as aggregation-prone proteins upon accumulation. With proteasome inhibitors being increasingly used as front-line treatment in cancer, these data raise issues about CT antigen processing for antigenic presentation and therefore immunogenicity in cancer patients.

  17. Plato: A localised orbital based density functional theory code

    Science.gov (United States)

    Kenny, S. D.; Horsfield, A. P.

    2009-12-01

    The Plato package allows both orthogonal and non-orthogonal tight-binding as well as density functional theory (DFT) calculations to be performed within a single framework. The package also provides extensive tools for analysing the results of simulations as well as a number of tools for creating input files. The code is based upon the ideas first discussed in Sankey and Niklewski (1989) [1] with extensions to allow high-quality DFT calculations to be performed. DFT calculations can utilise either the local density approximation or the generalised gradient approximation. Basis sets from minimal basis through to ones containing multiple radial functions per angular momenta and polarisation functions can be used. Illustrations of how the package has been employed are given along with instructions for its utilisation. Program summaryProgram title: Plato Catalogue identifier: AEFC_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEFC_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 219 974 No. of bytes in distributed program, including test data, etc.: 1 821 493 Distribution format: tar.gz Programming language: C/MPI and PERL Computer: Apple Macintosh, PC, Unix machines Operating system: Unix, Linux and Mac OS X Has the code been vectorised or parallelised?: Yes, up to 256 processors tested RAM: Up to 2 Gbytes per processor Classification: 7.3 External routines: LAPACK, BLAS and optionally ScaLAPACK, BLACS, PBLAS, FFTW Nature of problem: Density functional theory study of electronic structure and total energies of molecules, crystals and surfaces. Solution method: Localised orbital based density functional theory. Restrictions: Tight-binding and density functional theory only, no exact exchange. Unusual features: Both atom centred and uniform meshes available

  18. Idealization of The Real Stirling Cycle

    Directory of Open Access Journals (Sweden)

    Červenka Libor

    2016-12-01

    Full Text Available The paper presents a potential idealization of the real Stirling cycle. This idealization is performed by modifying the piston movement corresponding to the ideal Stirling cycle. The focus is on the cycle thermodynamics with respect to the indicated efficiency and indicated power. A detailed 1-D simulation model of a Stirling engine is used as a tool for this assessment. The model includes real non-zero volumes of heater, regenerator, cooler and connecting pipe. The model is created in the GT Power commercial simulation software.

  19. Predicting film genres with implicit ideals

    Directory of Open Access Journals (Sweden)

    Andrew McGregor Olney

    2013-01-01

    Full Text Available We present a new approach to defining film genre based on implicit ideals. When viewers rate the likability of a film, they indirectly express their ideal of what a film should be. Across six studies we investigate the category structure that emerges from likability ratings and the category structure that emerges from the features of film. We further compare these data-driven category structures with human annotated film genres. We conclude that film genres are structured more around ideals than around features of film. This finding lends experimental support to the notion that film genres are set of shifting, fuzzy, and highly contextualized psychological categories.

  20. Predicting film genres with implicit ideals.

    Science.gov (United States)

    Olney, Andrew McGregor

    2012-01-01

    We present a new approach to defining film genre based on implicit ideals. When viewers rate the likability of a film, they indirectly express their ideal of what a film should be. Across six studies we investigate the category structure that emerges from likability ratings and the category structure that emerges from the features of film. We further compare these data-driven category structures with human annotated film genres. We conclude that film genres are structured more around ideals than around features of film. This finding lends experimental support to the notion that film genres are set of shifting, fuzzy, and highly contextualized psychological categories.

  1. A principle for ideal torus knots

    DEFF Research Database (Denmark)

    Olsen, Kasper Wibeck; Bohr, Jakob

    2013-01-01

    Using bent-helix embeddings, we investigate simple and knotted torus windings that are made of tubes of finite thickness. Knots which have the shortest rope length are often denoted as ideal structures. Conventionally, the ideal structures are found by rope shortening routines. It is shown...... that alternatively they can be directly determined as maximally twisted structures. In many cases these structures are also structures with zero strain-twist coupling, i.e. structures that neither rotate one or the other way under strain. We use this principle to implement rapid numerical calculations of the ideal...

  2. Publishing to become an 'ideal academic'

    DEFF Research Database (Denmark)

    Lund, Rebecca

    2012-01-01

    In this paper I offer an Institutional Ethnography, from the standpoint of female academics, of the construction of the “ideal academic” and quality journal publications as a central feature in this construct. I draw on interview transcripts, field notes, texts and artefacts produced and collected...... over a two-year period in a recently merged Finnish university. I focus specifically on how a translocal discourse of competitive performance measurement and standards of academic excellence are accomplished in the local construction of the “ideal academic” as a person who publishes articles in A level......, in a systematically disadvantaged relation to the currently dominating discourse of the “ideal academic”....

  3. Predicting Film Genres with Implicit Ideals

    Science.gov (United States)

    Olney, Andrew McGregor

    2013-01-01

    We present a new approach to defining film genre based on implicit ideals. When viewers rate the likability of a film, they indirectly express their ideal of what a film should be. Across six studies we investigate the category structure that emerges from likability ratings and the category structure that emerges from the features of film. We further compare these data-driven category structures with human annotated film genres. We conclude that film genres are structured more around ideals than around features of film. This finding lends experimental support to the notion that film genres are set of shifting, fuzzy, and highly contextualized psychological categories. PMID:23423823

  4. Edge conduction in vacuum glazing

    Energy Technology Data Exchange (ETDEWEB)

    Simko, T.M.; Collins, R.E. [Sydney Univ., NSW (Australia). Dept. of Applied Physics; Beck, F.A.; Arasteh, D. [Lawrence Berkeley Lab., CA (United States)

    1995-03-01

    Vacuum glazing is a form of low-conductance double glazing using in internal vacuum between the two glass sheets to eliminate heat transport by gas conduction and convection. An array of small support pillars separates the sheets; fused solder glass forms the edge seal. Heat transfer through the glazing occurs by radiation across the vacuum gap, conduction through the support pillars, and conduction through the bonded edge seal. Edge conduction is problematic because it affects stresses in the edge region, leading to possible failure of the glazing; in addition, excessive heat transfer because of thermal bridging in the edge region can lower overall window thermal performance and decrease resistance to condensation. Infrared thermography was used to analyze the thermal performance of prototype vacuum glazings, and, for comparison, atmospheric pressure superwindows. Research focused on mitigating the edge effects of vacuum glazings through the use of insulating trim, recessed edges, and framing materials. Experimentally validated finite-element and finite-difference modeling tools were used for thermal analysis of prototype vacuum glazing units and complete windows. Experimental measurements of edge conduction using infrared imaging were found to be in good agreement with finite-element modeling results for a given set of conditions. Finite-element modeling validates an analytic model developed for edge conduction.

  5. Edge Bundling in Information Visualization

    National Research Council Canada - National Science Library

    Hong Zhou Panpan Xu Xiaoru Yuan Huamin Qu

    2013-01-01

    The edge, which can encode relational data in graphs and multidimensional data in parallel coordinates plots, is an important visual primitive for encoding data in information visualization research...

  6. Two oppositely localised frizzled RNAs as axis determinants in a cnidarian embryo.

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Momose

    2007-04-01

    Full Text Available In phylogenetically diverse animals, including the basally diverging cnidarians, "determinants" localised within the egg are responsible for directing development of the embryonic body plan. Many such determinants are known to regulate the Wnt signalling pathway, leading to regionalised stabilisation of the transcriptional coregulator beta-catenin; however, the only strong molecular candidate for a Wnt-activating determinant identified to date is the ligand Wnt11 in Xenopus. We have identified embryonic "oral-aboral" axis determinants in the cnidarian Clytia hemisphaerica in the form of RNAs encoding two Frizzled family Wnt receptors, localised at opposite poles of the egg. Morpholino-mediated inhibition of translation showed that CheFz1, localised at the animal pole, activates the canonical Wnt pathway, promotes oral fates including gastrulation, and may also mediate global polarity in the ectoderm. CheFz3, whose RNA is localised at the egg vegetal cortex, was found to oppose CheFz1 function and to define an aboral territory. Active downregulation mechanisms maintained the reciprocal localisation domains of the two RNAs during early development. Importantly, ectopic expression of either CheFz1 or CheFz3 was able to redirect axis development. These findings identify Frizzled RNAs as axis determinants in Clytia, and have implications for the evolution of embryonic patterning mechanisms, notably that diverse Wnt pathway regulators have been adopted to initiate asymmetric Wnt pathway activation.

  7. Pharmacological Characterisation and Autoradiographic Localisation of Dopamine Receptor Subtypes in the Cardiovascular System and in the Kidney

    National Research Council Canada - National Science Library

    Amenta, Francesco; Ferrante, Fabio; Ricci, Alberto

    1995-01-01

    Combined radioligand binding and light microscope autoradiography techniques were used for investigating the pharmacological profile and the microanatomical localisation of dopamine receptor subtypes...

  8. Medical learning curves and the Kantian ideal.

    Science.gov (United States)

    Le Morvan, P; Stock, B

    2005-09-01

    A hitherto unexamined problem for the "Kantian ideal" that one should always treat patients as ends in themselves, and never only as a means to other ends, is explored in this paper. The problem consists of a prima facie conflict between this Kantian ideal and the reality of medical practice. This conflict arises because, at least presently, medical practitioners can only acquire certain skills and abilities by practising on live, human patients, and given the inevitability and ubiquity of learning curves, this learning requires some patients to be treated only as a means to this end. A number of ways of attempting to establish the compatibility of the Kantian Ideal with the reality of medical practice are considered. Each attempt is found to be unsuccessful. Accordingly, until a way is found to reconcile them, we conclude that the Kantian ideal is inconsistent with the reality of medical practice.

  9. Neutrosophic Crisp Points & Neutrosophic Crisp Ideals

    Directory of Open Access Journals (Sweden)

    A. A. Salama

    2013-03-01

    Full Text Available The purpose of this paper is to define the so called "neutrosophic crisp points" and "neutrosophic crisp ideals", and obtain their fundamental properties. Possible application to GIS topology rules are touched upon.

  10. En busca de ideales educativos postipograficos

    National Research Council Canada - National Science Library

    Giesecke, Michael; Garcia-Leguizamon, Fernando

    2009-01-01

    .... El intento de preservar en el siglo XXI los ideales de la cultura del libro y de optimizar estructuras existentes por medio de la digitalizacion, el e-learning y la interconexion electronica, parece algo inevitable...

  11. Regularity of Tor for weakly stable ideals

    Directory of Open Access Journals (Sweden)

    Katie Ansaldi

    2015-05-01

    Full Text Available It is proved that if I and J are weakly stable ideals in a polynomial ring R = k[x_1, . . ., x_n], with k a field, then the regularity of Tor^R_i (R/I, R/J has the expected upper bound. We also give a bound for the regularity of Ext^i_R (R/I, R for I a weakly stable ideal.

  12. Sahaja: an Indian ideal of mental health.

    Science.gov (United States)

    Neki, J S

    1975-02-01

    Sahaja is an Indian ideal of mental and spiritual health that has received special emphasis in the Sikh scriptures--especially, the Adi Granth. Since the concept of sahaja has long been associated with mystical thought and practice, its description has become shrouded in peculiar esoteric terminologies. It is the purpose of this communication to divest sahaja of its esoteric, mystic connotations and to redefine it as a mental health ideal in the context of contemporary conditions.

  13. Hydraulics of IDEal Drip Irrigation Systems

    OpenAIRE

    Thompson, Evan J

    2009-01-01

    The hydraulics of IDEal drip irrigation system components were analyzed under controlled laboratory conditions and the results can be applied to the design of IDEal systems. The hydraulic loss coefficient for the lateral-submain connector valves was determined based on laboratory measurements. It was found that the hydraulic loss due to friction in the lay-flat laterals can be accurately estimated with standard friction loss equations using a smaller effective diameter based on the wall thi...

  14. Restoring the incisal edge.

    Science.gov (United States)

    Terry, Douglas A

    2005-01-01

    Restorative dentistry evolves with each development of new material and innovative technique. Selection of improved restorative materials that simulate the physical properties and other characteristics of natural teeth, in combination with restorative techniques such as the proximal adaptation and incremental layering, provide the framework that ensures the optimal development of an esthetic restoration. These advanced placement techniques offer benefits such as enhanced chromatic integration, polychromatism, ideal anatomical form and function, optimal proximal contact, improved marginal integrity and longer lasting directly placed composite restorations. The purpose of this article is to give the reader a better understanding of the complex restorative challenge in achieving true harmonization of the primary parameters in esthetics (that is, color, shape and texture) represented by the replacement of a single anterior tooth. The case presented demonstrates the restoration of a Class IV fracture integrating basic adhesive principles with these placement techniques and a recently developed nanoparticle hybrid composite resin system (Premise, Kerr/Sybron, Orange, CA). The clinical presentation describes preoperative considerations, tooth preparation, development of the body layer, internal characterization with tints, development of the artificial enamel layer, shaping and contouring, and polishing of a Class IV composite restoration. The clinical significance is that anterior tooth fractures can be predictably restored using contemporary small particle hybrid composite resin systems with the aforementioned restorative techniques. These placement techniques when used with proper attention to preparation design, adhesive protocol and finishing and polishing procedures, allow the clinician to successfully restore form, function and esthetics to the single anterior tooth replacement.

  15. The Robotic Edge Finishing Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Loucks, C.S.; Selleck, C.B.

    1990-08-01

    The Robotic Edge Finishing Laboratory at Sandia National Laboratories is developing four areas of technology required for automated deburring, chamfering, and blending of machined edges: (1) the automatic programming of robot trajectories and deburring processes using information derived from a CAD database, (2) the use of machine vision for locating the workpiece coupled with force control to ensure proper tool contact, (3) robotic deburring, blending, and machining of precision chamfered edges, and (4) in-process automated inspection of the formed edge. The Laboratory, its components, integration, and results from edge finishing experiments to date are described here. Also included is a discussion of the issues regarding implementation of the technology in a production environment. 24 refs., 17 figs.

  16. Edge instabilities of topological superconductors

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, Johannes S. [Institut fuer Theoretische Physik und Astrophysik, Universitaet Wuerzburg (Germany); Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany); Assaad, Fakher F. [Institut fuer Theoretische Physik und Astrophysik, Universitaet Wuerzburg (Germany); Schnyder, Andreas P. [Max-Planck-Institut fuer Festkoerperforschung, Stuttgart (Germany)

    2016-07-01

    Nodal topological superconductors display zero-energy Majorana flat bands at generic edges. The flatness of these edge bands, which is protected by time-reversal and translation symmetry, gives rise to an extensive ground state degeneracy and a diverging density of states. Therefore, even arbitrarily weak interactions lead to an instability of the flat-band edge states towards time-reversal and translation-symmetry broken phases, which lift the ground-state degeneracy. Here, we employ Monte Carlo simulations combined with mean-field considerations to examine the instabilities of the flat-band edge states of d{sub xy}-wave superconductors. We find that attractive interactions induce a complex s-wave pairing instability together with a density wave instability. Repulsive interactions, on the other hand, lead to ferromagnetism mixed with spin-triplet pairing at the edge. We discuss the implications of our findings for experiments on cuprate high-temperature superconductors.

  17. Flows and Stratification of an Enclosure Containing Both Localised and Vertically Distributed Sources of Buoyancy

    Science.gov (United States)

    Partridge, Jamie; Linden, Paul

    2013-11-01

    We examine the flows and stratification established in a naturally ventilated enclosure containing both a localised and vertically distributed source of buoyancy. The enclosure is ventilated through upper and lower openings which connect the space to an external ambient. Small scale laboratory experiments were carried out with water as the working medium and buoyancy being driven directly by temperature differences. A point source plume gave localised heating while the distributed source was driven by a controllable heater mat located in the side wall of the enclosure. The transient temperatures, as well as steady state temperature profiles, were recorded and are reported here. The temperature profiles inside the enclosure were found to be dependent on the effective opening area A*, a combination of the upper and lower openings, and the ratio of buoyancy fluxes from the distributed and localised source Ψ =Bw/Bp . Industrial CASE award with ARUP.

  18. Towards a Multimodal Methodology for the Analysis of Translated/Localised Games

    Directory of Open Access Journals (Sweden)

    Bárbara Resende Coelho

    2016-12-01

    Full Text Available Multimedia materials require research methodologies that are able to comprehend all of their assets. Videogames are the epitome of multimedia, joining image, sound, video, animation, graphics and text with the interactivity factor. A methodology to conduct research into translation and localisation of videogames should be able to analyse all of its assets and features. This paper sets out to develop a research methodology for games and their translations/localisations that goes beyond the collection and analysis of “screenshots” and includes as many of their assets as possible. Using the fully localised version of the game Watchdogs, this papers shows how tools and technologies allow for transcending the mere analysis of linguistic contents within multimedia materials. Using software ELAN Language Archive to analyse Portuguese-language dubbed and English-language subtitled excerpts from the videogame, it was possible to identify patterns in both linguistic and audio-visual elements, as well as to correlate them.

  19. Sensor fusion for the localisation of birds in flight

    Science.gov (United States)

    Millikin, Rhonda Lorraine

    Tracking and identification of birds in flight remains a goal of aviation safety worldwide and conservation in North America. Marine surveillance radar, tracking radar and more recently weather radar have been used to monitor mass movements of birds. The emphasis has been on prediction of migration fronts where thousands of birds follow weather patterns across a large geographic area. Microphones have been stationed over wide areas to receive calls of these birds and help catalogue the diversity of species comprising these migrations. A most critical feature of landbird migration is where the birds land to rest and feed. These habitats are not known and therefore cannot effectively be protected. For effective management of landbird migrants (nocturnal migrant birds), short-range flight behaviour (100--300 m above ground) is the critical air space to monitor. To ensure conservation efforts are focused on endangered species and species truly at risk, species of individual birds must be identified. Short-range monitoring of individual birds is also important for aviation safety. Up to 75% of bird-aircraft collisions occur within 500 ft (153 m) above the runway. Identification of each bird will help predict its flight path, a critical factor in the prevention of a collision. This thesis focuses on short-range identification of individual birds to localise birds in flight. This goal is achieved through fusing data from two sensor systems, radar and acoustic. This fusion provides more accurate tracking of birds in the lower airspace and allows for the identification of species of interest. In the fall of 1999, an experiment was conducted at Prince Edward Point, a southern projection of land on the north shore of Lake Ontario, to prove that the fusion of radar and acoustic sensors enhances the detection, location and tracking of nocturnal migrant birds. As these birds migrate at night, they are difficult to track visually. However, they are detectable with X

  20. Divergent RNA Localisation Patterns of Maternal Genes Regulating Embryonic Patterning in the Butterfly Pararge aegeria.

    Directory of Open Access Journals (Sweden)

    Jean-Michel Carter

    Full Text Available The maternal effect genes responsible for patterning the embryo along the antero-posterior (AP axis are broadly conserved in insects. The precise function of these maternal effect genes is the result of the localisation of their mRNA in the oocyte. The main developmental mechanisms involved have been elucidated in Drosophila melanogaster, but recent studies have shown that other insect orders often diverge in RNA localisation patterns. A recent study has shown that in the butterfly Pararge aegeria the distinction between blastodermal embryonic (i.e. germ band and extra-embryonic tissue (i.e. serosa is already specified in the oocyte during oogenesis in the ovariole, long before blastoderm cellularisation. To examine the extent by which a female butterfly specifies and patterns the AP axis within the region fated to be the germ band, and whether she specifies a germ plasm, we performed in situ hybridisation experiments on oocytes in P. aegeria ovarioles and on early embryos. RNA localisation of the following key maternal effect genes were investigated: caudal (cad, orthodenticle (otd, hunchback (hb and four nanos (nos paralogs, as well as TDRD7 a gene containing a key functional domain (OST-HTH/LOTUS shared with oskar. TDRD7 was mainly confined to the follicle cells, whilst hb was exclusively zygotically transcribed. RNA of some of the nos paralogs, otd and cad revealed complex localisation patterns within the cortical region prefiguring the germ band (i.e. germ cortex. Rather interestingly, otd was localised within and outside the anterior of the germ cortex. Transcripts of nos-O formed a distinct granular ring in the middle of the germ cortex possibly prefiguring the region where germline stem cells form. These butterfly RNA localisation patterns are highly divergent with respect to other insects, highlighting the diverse ways in which different insect orders maternally regulate early embryogenesis of their offspring.

  1. Divergent RNA Localisation Patterns of Maternal Genes Regulating Embryonic Patterning in the Butterfly Pararge aegeria.

    Science.gov (United States)

    Carter, Jean-Michel; Gibbs, Melanie; Breuker, Casper J

    2015-01-01

    The maternal effect genes responsible for patterning the embryo along the antero-posterior (AP) axis are broadly conserved in insects. The precise function of these maternal effect genes is the result of the localisation of their mRNA in the oocyte. The main developmental mechanisms involved have been elucidated in Drosophila melanogaster, but recent studies have shown that other insect orders often diverge in RNA localisation patterns. A recent study has shown that in the butterfly Pararge aegeria the distinction between blastodermal embryonic (i.e. germ band) and extra-embryonic tissue (i.e. serosa) is already specified in the oocyte during oogenesis in the ovariole, long before blastoderm cellularisation. To examine the extent by which a female butterfly specifies and patterns the AP axis within the region fated to be the germ band, and whether she specifies a germ plasm, we performed in situ hybridisation experiments on oocytes in P. aegeria ovarioles and on early embryos. RNA localisation of the following key maternal effect genes were investigated: caudal (cad), orthodenticle (otd), hunchback (hb) and four nanos (nos) paralogs, as well as TDRD7 a gene containing a key functional domain (OST-HTH/LOTUS) shared with oskar. TDRD7 was mainly confined to the follicle cells, whilst hb was exclusively zygotically transcribed. RNA of some of the nos paralogs, otd and cad revealed complex localisation patterns within the cortical region prefiguring the germ band (i.e. germ cortex). Rather interestingly, otd was localised within and outside the anterior of the germ cortex. Transcripts of nos-O formed a distinct granular ring in the middle of the germ cortex possibly prefiguring the region where germline stem cells form. These butterfly RNA localisation patterns are highly divergent with respect to other insects, highlighting the diverse ways in which different insect orders maternally regulate early embryogenesis of their offspring.

  2. Analysis of lesion localisation at colonoscopy: outcomes from a multi-centre U.K. study.

    Science.gov (United States)

    Moug, Susan J; Fountas, Spyridon; Johnstone, Mark S; Bryce, Adam S; Renwick, Andrew; Chisholm, Lindsey J; McCarthy, Kathryn; Hung, Amy; Diament, Robert H; McGregor, John R; Khine, Myo; Saldanha, James D; Khan, Khurram; Mackay, Graham; Leitch, E Fiona; McKee, Ruth F; Anderson, John H; Griffiths, Ben; Horgan, Alan; Lockwood, Sonia; Bisset, Carly; Molloy, Richard; Vella, Mark

    2017-07-01

    Colonoscopy is currently the gold standard for detection of colorectal lesions, but may be limited in anatomically localising lesions. This audit aimed to determine the accuracy of colonoscopy lesion localisation, any subsequent changes in surgical management and any potentially influencing factors. Patients undergoing colonoscopy prior to elective curative surgery for colorectal lesion/s were included from 8 registered U.K. sites (2012-2014). Three sets of data were recorded: patient factors (age, sex, BMI, screener vs. symptomatic, previous abdominal surgery); colonoscopy factors (caecal intubation, scope guide used, colonoscopist accreditation) and imaging modality. Lesion localisation was standardised with intra-operative location taken as the gold standard. Changes to surgical management were recorded. 364 cases were included; majority of lesions were colonic, solitary, malignant and in symptomatic referrals. 82% patients had their lesion/s correctly located at colonoscopy. Pre-operative CT visualised lesion/s in only 73% of cases with a reduction in screening patients (64 vs. 77%; p = 0.008). 5.2% incorrectly located cases at colonoscopy underwent altered surgical management, including conversion to open. Univariate analysis found colonoscopy accreditation, scope guide use, incomplete colonoscopy and previous abdominal surgery significantly influenced lesion localisation. On multi-variate analysis, caecal intubation and scope guide use remained significant (HR 0.35, 0.20-0.60 95% CI and 0.47; 0.25-0.88, respectively). Lesion localisation at colonoscopy is incorrect in 18% of cases leading to potentially significant surgical management alterations. As part of accreditation, colonoscopists need lesion localisation training and awareness of when inaccuracies can occur.

  3. Definition and characterization of localised meningitis epidemics in Burkina Faso: a longitudinal retrospective study

    Directory of Open Access Journals (Sweden)

    Tall Haoua

    2012-01-01

    Full Text Available Abstract Background The epidemiology of meningococcal meningitis in the African meningitis belt is characterised by seasonality, localised epidemics and epidemic waves. To facilitate research and surveillance, we aimed to develop a definition for localised epidemics to be used in real-time surveillance based on weekly case reports at the health centre level. Methods We used national routine surveillance data on suspected meningitis from January 2004 to December 2008 in six health districts in western and central Burkina Faso. We evaluated eight thresholds composed of weekly incidence rates at health centre level for their performance in predicting annual incidences of 0.4%and 0.8% in health centre areas. The eventually chosen definition was used to describe the spatiotemporal epidemiology and size of localised meningitis epidemics during the included district years. Results Among eight weekly thresholds evaluated, a weekly incidence rate of 75 cases per 100,000 inhabitants during at least two consecutive weeks with at least 5 cases per week had 100% sensitivity and 98% specificity for predicting an annual incidence of at least 0.8% in health centres. Using this definition, localised epidemics were identified in all but one years during 2004-2008, concerned less than 10% of the districts' population and often were geographically dispersed. Where sufficient laboratory data were available, localised epidemics were exclusively due to meningococci. Conclusions This definition of localised epidemics a the health centre level will be useful for risk factor and modelling studies to understand the meningitis belt phenomenon and help documenting vaccine impact against epidemic meningitis where no widespread laboratory surveillance exists for quantifying disease reduction after vaccination.

  4. EDUCATIONAL IDEAL OF UKRAINIAN ETHNOPEDAGOGIES: CARPATHIAN VECTOR

    Directory of Open Access Journals (Sweden)

    Nelly Lysenko

    2015-04-01

    Full Text Available Educational ideal, methods, forms and means of folk-educational influence on its formation, starting from the first years of baby’s life are topical problems for researchers. The main element is an aim. The aim is an ideal image of the expecting result which is regarded as a guide for the educational activity of a certain ethnic community. The content of the notion of educational ideal is the imagery about the most important qualities of a personality, their manners, culture of relationship in the society, behavior. Ukrainian mentality is practicality, rationality, generosity, intellect in general. It is fully reflected in the pedagogical aim. At the same time mental means spiritual. That is something in thoughts and intents of a person. It is important to emphasize that Ukrainian ethos was formed on the basis of several groups, not only having formed a nation, but also having synthesized the temperament, traditions and customs, clothes and everyday life, culture in general. Hutsul, Boyko, Lemko (121 ethnic groups all together differ by the uniqueness of the appearance. At the same time their internal essence, that is educational ideal, world view, ethic morals, are unchangeable. Educational ideal is historically determined. Esthetic strategies, formation of creativity, development of the abilities by the means of folk crafts and trades, upbringing of a host pierce through the educational ideal of nowadays Ukrainians. The people aim to bring up their children as true citizens: good kids mean quiet old age, while with evil children old age becomes a hell. Thus, the educational ideal of the Ukrainians should be considered as a basis for modern educational technologies projection.

  5. Damage localisation in a stiffened plate structure using a propagating wave

    Science.gov (United States)

    Radzieński, Maciej; Doliński, Łukasz; Krawczuk, Marek; Palacz, Magdalena

    2013-08-01

    The paper presents an application of changes in propagating waves for damage detection in a stiffened aluminium plate. The experimental investigation was conducted on an aluminium plate with riveted two L-shape stiffeners. The wave has been excited with a piezoelectric transducer and measured with the Laser Scanning Doppler Vibrometer. Recorded signals were analysed using the special signal processing techniques developed for damage detection. The influence of different wave signals on damage localisation process for various damage scenarios has been tested. The obtained results were presented in a form of numerical maps. It may be concluded that the proposed approach enables damage localisation in a relatively fast and precise manner.

  6. Strain localisation in mechanically layered rocks beneath detachment zones: insights from numerical modelling

    Directory of Open Access Journals (Sweden)

    L. Le Pourhiet

    2013-04-01

    Full Text Available We have designed a series of fully dynamic numerical simulations aimed at assessing how the orientation of mechanical layering in rocks controls the orientation of shear bands and the depth of penetration of strain in the footwall of detachment zones. Two parametric studies are presented. In the first one, the influence of stratification orientation on the occurrence and mode of strain localisation is tested by varying initial dip of inherited layering in the footwall with regard to the orientation of simple shear applied at the rigid boundary simulating a rigid hanging wall, all scaling and rheological parameter kept constant. It appears that when Mohr–Coulomb plasticity is being used, shear bands are found to localise only when the layering is being stretched. This corresponds to early deformational stages for inital layering dipping in the same direction as the shear is applied, and to later stages for intial layering dipping towards the opposite direction of shear. In all the cases, localisation of the strain after only γ=1 requires plastic yielding to be activated in the strong layer. The second parametric study shows that results are length-scale independent and that orientation of shear bands is not sensitive to the viscosity contrast or the strain rate. However, decreasing or increasing strain rate is shown to reduce the capacity of the shear zone to localise strain. In the later case, the strain pattern resembles a mylonitic band but the rheology is shown to be effectively linear. Based on the results, a conceptual model for strain localisation under detachment faults is presented. In the early stages, strain localisation occurs at slow rates by viscous shear instabilities but as the layered media is exhumed, the temperature drops and the strong layers start yielding plastically, forming shear bands and localising strain at the top of the shear zone. Once strain localisation has occured, the deformation in the shear band becomes

  7. Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product

    Energy Technology Data Exchange (ETDEWEB)

    Chan, S.Y.T.; Evan, G.I.; Ritson, A.; Watson, J.; Wraight, P.; Sikora, K.

    1986-11-01

    A set of mouse monoclonal antibodies against the c-myc oncogene product, a 62,000 dalton nuclear binding protein involved in cell cycle control, has been constructed by immunisation with synthetic peptide fragments. One such antibody, CT14, was radiolabelled with /sup 131/I and administered to 20 patients with different malignant diseases. Good tumour localisation was observed in 12 out of 14 patients with primary bronchial carcinoma but not in patients with pulmonary metastases from primary tumours elsewhere. Successfully localised tumours were all 3 cm or more in diameter. Monoclonal antibodies against oncogene products may provide novel selective tools for the diagnosis and therapy of cancer.

  8. Sub-microsecond temporal evolution of edge density during edge localized modes in KSTAR tokamak plasmas inferred from ion cyclotron emission

    Science.gov (United States)

    Chapman, B.; Dendy, R. O.; McClements, K. G.; Chapman, S. C.; Yun, G. S.; Thatipamula, S. G.; Kim, M. H.

    2017-12-01

    During edge localised mode (ELM) crashes in KSTAR deuterium plasmas, bursts of spectrally structured ion cyclotron emission (ICE) are detected. Usually the ICE spectrum chirps downwards during an ELM crash, on sub-microsecond timescales. For KSTAR ICE where the separation of spectral peak frequencies is close to the proton cyclotron frequency Ω_cp at the outer plasma edge, we show that the driving population of energetic ions is likely to be a subset of the 3 MeV fusion protons, born centrally on deeply passing orbits which drift from the core to the edge plasma. We report first principles modelling of this scenario using a particle-in-cell code, which evolves the full orbit dynamics of large numbers of energetic protons, thermal deuterons, and electrons self-consistently with the electric and magnetic fields. The Fourier transform of the excited fields in the nonlinear saturated regime of the simulations is the theoretical counterpart to the measured ICE spectra. Multiple simulation runs for different, adjacent, values of the plasma density under KSTAR edge conditions enable us to infer the theoretical dependence of ICE spectral structure on the local electron number density. By matching this density dependence to the observed time-dependence of chirping ICE spectra in KSTAR, we obtain sub-microsecond time resolution of the evolving local electron number density during the ELM crash.

  9. Page 1 | Bertini theorems for ideals linked to a given ideal 329 ...

    Indian Academy of Sciences (India)

    where k = r + 1 and aire Ry, then T. = det([0,1-1-X, angul,”,)Rp. Since height I = r and I is a local complete intersection in codim.1, the ideal I is generated by relements, at prime ideals of height 1 in R/I. Since R/I is a reduced ring, the nonregular locus is of codim. - 1. Therefore the set F, of all minimal prime ideals and non ...

  10. Quest for ideal weight: costs and consequences.

    Science.gov (United States)

    Lindeman, A K

    1999-08-01

    The quest to achieve the ideal weight comes with notable costs. Dieting carries the financial costs of professional consulting, low-calorie foods, books and materials, and diet programming. Club memberships, clothing, equipment, and time all contribute to the cost of exercise. Cosmetic surgery to achieve the desired physique carries a significant financial, and sometimes psychological, burden. Women often pursue thinner bodies despite already being at a healthy weight. This pursuit is motivated primarily to enhance appearance. The ideal body portrayed in the media has stabilized in thinness, but it is becoming increasingly tubular, i.e., taller with slimmer hips and thicker waist. This ideal is presented to adult and adolescent women in their popular magazines, and to little girls with their dolls. Exercise is promoted as an optimal means to achieve the ideal physique. Young American women tend to idealize an athletic body shape, especially with upper-body muscularity. This shape can be attained only through sustained exercise and upper-body strength training. High-level exercise may be a precursor to eating disorders. Women who exercise to excess, who are highly preoccupied with weight, and who are characterized by perfectionism and an obsessive compulsive personality are at risk for eating disorders. When body weight and shape are kept in perspective and realistic goals are set, the physical, psychological, and financial costs of achieving or maintaining a healthy weight may be minimized.

  11. IDEAL Problem Solving dalam Pembelajaran Matematika

    Directory of Open Access Journals (Sweden)

    Eny Susiana

    2012-01-01

    Full Text Available Most educators agree that problem solving is among the most meaningful and importantkinds of learning and thingking. That is, the central focus of learning and instructionshould be learning to solve problems. There are several warrants supporting that claims.They are authenticity, relevance, problem solving engages deeper learning angtherefore enhances meaning making, and constructed to represent problems (problemsolving is more meaningful. It is the reason why we must provide teaching and learningto make student’s problem solving skill in progress. There are many informationprocessingmodels of problem solving, such as simplified model of the problem-solvingprocess by Gicks, Polya’s problem solving process etc. One of them is IDEAL problemsolving. Each letter of IDEAL is stand for an aspect of thinking that is important forproblem solving. IDEAL is identify problem, Define Goal, Explore possible strategies,Anticipate outcme and Act, and Look back and learn. Using peer interaction andquestion prompt in small group in IDEAL problem solving teaching and Learning canimprove problem solving skill.Kata kunci: IDEAL Problem Solving, Interaksi Sebaya, Pertanyaan Penuntun, KelompokKecil.

  12. Effect of Edge Roughness on Static Characteristics of Graphene Nanoribbon Field Effect Transistor

    Directory of Open Access Journals (Sweden)

    Yaser M. Banadaki

    2016-03-01

    Full Text Available In this paper, we present a physics-based analytical model of GNR FET, which allows for the evaluation of GNR FET performance including the effects of line-edge roughness as its practical specific non-ideality. The line-edge roughness is modeled in edge-enhanced band-to-band-tunneling and localization regimes, and then verified for various roughness amplitudes. Corresponding to these two regimes, the off-current is initially increased, then decreased; while, on the other hand, the on-current is continuously decreased by increasing the roughness amplitude.

  13. Comparison of Real and Idealized Cetacean Flippers

    Science.gov (United States)

    2009-10-16

    whale, Balaenoptera physalus; long-finned pilot whale, Globicephala melas ; killer whale, Orcinus orca; harbour porpoise, Phocoena phocoena; bottlenose...0.232 20/0.32 Idealized 0.059 120 0.239 Long-finned pilot whale ( Globicephala melas ) Real 0.107 115 0.159 10.82/0.43 Idealized 0.106 116 0.160 (a) (b...Experimental data for long-finned pilot whale Globicephala melas flipper models. Note the nonlinear nature of the lift curves. The results for the

  14. Lectures on the asymptotic theory of ideals

    CERN Document Server

    Rees, D

    1988-01-01

    In this book Professor Rees introduces and proves some of the main results of the asymptotic theory of ideals. The author's aim is to prove his Valuation Theorem, Strong Valuation Theorem, and Degree Formula, and to develop their consequences. The last part of the book is devoted to mixed multiplicities. Here the author develops his theory of general elements of ideals and gives a proof of a generalised degree formula. The reader is assumed to be familiar with basic commutative algebra, as covered in the standard texts, but the presentation is suitable for advanced graduate students. The work

  15. Ideal Clutters That Do Not Pack

    Science.gov (United States)

    2016-09-18

    class of objects, called marginal cuboids, that naturally give rise to ideal non-packing clutters with covering number two. We present an explicit...class of marginal cuboids, and show that the corresponding clutters have one of Q6, Q2,1, Q10 as a minor, where Q6, Q2,1 are known ideal mnp clutters...clutter C0 where τ(C0) = 2, and (iv) C0 is a marginal cuboid. This result is proved in §5. We will define marginal cuboids shortly. Statement (iv

  16. Benchmarking Tokamak edge modelling codes

    Science.gov (United States)

    Contributors To The Efda-Jet Work Programme; Coster, D. P.; Bonnin, X.; Corrigan, G.; Kirnev, G. S.; Matthews, G.; Spence, J.; Contributors to the EFDA-JET work programme

    2005-03-01

    Tokamak edge modelling codes are in widespread use to interpret and understand existing experiments, and to make predictions for future machines. Little direct benchmarking has been done between the codes, and the users of the codes have tended to concentrate on different experimental machines. An important validation step is to compare the codes for identical scenarios. In this paper, two of the major edge codes, SOLPS (B2.5-Eirene) and EDGE2D-NIMBUS are benchmarked against each other. A set of boundary conditions, transport coefficients, etc. for a JET plasma were chosen, and the two codes were run on the same grid. Initially, large differences were seen in the resulting plasmas. These differences were traced to differing physics assumptions with respect to the parallel heat flux limits. Once these were switched off in SOLPS, or implemented and switched on in EDGE2D-NIMBUS, the remaining differences were small.

  17. Three-dimensional sound localisation with a lizard peripheral auditory model

    DEFF Research Database (Denmark)

    Schmidt, Michael Kjær; Shaikh, Danish

    -related transfer functions [Cheng and Wakefield 2001]. Here we present a preliminary sensorimotor approach [Aytekin et al. 2007; Shaikh 2012] in simulation to three-dimensional sound source localisation employing two simulated microphones. We use directed spatial movements of the microphones to resolve the unknown...

  18. Empirical performance of RSSI-based Monte Carlo localisation for active RFID patient tracking systems

    NARCIS (Netherlands)

    Cully, William P.L.; Cotton, Simon L.; Scanlon, W.G.

    2012-01-01

    The range of potential applications for indoor and campus based personnel localisation has led researchers to create a wide spectrum of different algorithmic approaches and systems. However, the majority of the proposed systems overlook the unique radio environment presented by the human body

  19. Analytical geolocation and three-dimensional localisation by time difference of arrival

    NARCIS (Netherlands)

    Naus, H.W.L.

    2016-01-01

    Geolocation based on time differences of arrival measured by three sensors is studied. Closed-form analytical solutions are derived, even for the cases where one or more sensors are not located on the earth. Exploiting four sensors, full three-dimensional localisation is achieved as well. These

  20. Orthodontic treatment of localised gingival recession associated with traumatic anterior crossbite.

    Science.gov (United States)

    Seehra, Jadbinder; Fleming, Padhraig S; DiBiase, Andrew T

    2009-05-01

    Gingival recession can be defined as the apical shift of the marginal gingiva from its normal position on the crown of the tooth to levels on the root surface beyond the cemento-enamel junction. The aetiology of this condition is multifactorial, but can result from a traumatic occlusion. The long-term prognosis of teeth with localised gingival recession can be uncertain. Successful management of these cases may involve either orthodontic or periodontal treatment in isolation or in combination. To describe two patients in which localised gingival recession associated with anterior crossbites were corrected with orthodontic appliances. A 2 x 4 appliance and an upper removable appliance were used to correct the crossbites. Correction of the anterior crossbites resulted in a clinical improvement of the gingival recession. The aetiology and management of localised gingival recession is discussed. Simple orthodontic appliances can be used to provide interceptive treatment to correct localised crossbite and enhance the overall long-term prognosis of the lower incisors. To achieve optimal results multidisciplinary involvement is recommended.

  1. Localisation of Sensor Nodes with Hybrid Measurements in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Muhammad W. Khan

    2016-07-01

    Full Text Available Localisation in wireless networks faces challenges such as high levels of signal attenuation and unknown path-loss exponents, especially in urban environments. In response to these challenges, this paper proposes solutions to localisation problems in noisy environments. A new observation model for localisation of static nodes is developed based on hybrid measurements, namely angle of arrival and received signal strength data. An approach for localisation of sensor nodes is proposed as a weighted linear least squares algorithm. The unknown path-loss exponent associated with the received signal strength is estimated jointly with the coordinates of the sensor nodes via the generalised pattern search method. The algorithm’s performance validation is conducted both theoretically and by simulation. A theoretical mean square error expression is derived, followed by the derivation of the linear Cramer-Rao bound which serves as a benchmark for the proposed location estimators. Accurate results are demonstrated with 25%–30% improvement in estimation accuracy with a weighted linear least squares algorithm as compared to linear least squares solution.

  2. Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2

    NARCIS (Netherlands)

    Ruane, Peter T; Gumy, Laura F|info:eu-repo/dai/nl/337608334; Bola, Becky; Anderson, Beverley; Wozniak, Marcin J; Hoogenraad, Casper C|info:eu-repo/dai/nl/227263502; Allan, Victoria J

    2016-01-01

    Microtubules and their associated proteins (MAPs) underpin the polarity of specialised cells. Adenomatous polyposis coli (APC) is one such MAP with a multifunctional agenda that requires precise intracellular localisations. Although APC has been found to associate with kinesin-2 subfamily members,

  3. Utilisation de l'echographie doppler couleur dans la localisation de l ...

    African Journals Online (AJOL)

    Utilisation de l'echographie doppler couleur dans la localisation de l'insertion du cordon ombilical et le devenir materno-foetal à la maternité de l'hôpital central de Yaoundé : une étude descriptive et analytique.

  4. Localised hypertrophy of semimembranous muscle. A report of two cases in athletes.

    Science.gov (United States)

    Carrozza, M; Giombini, A; Dragoni, S; De Carolis, M; Bizzarri, F

    2001-09-01

    We report two cases of localised hypertrophy of semimembranous muscle in young athletes diagnosed with ultrasonography, flow color-Doppler and MRI. The symptomatic case had the resolution of the pain after one month rest. At one year follow-up both cases are still asymptomatic, without any further increase of the hypertrophyc masses.

  5. A machine-hearing system exploiting head movements for binaural sound localisation in reverberant conditions

    DEFF Research Database (Denmark)

    May, Tobias; Ma, Ning; Wierstorf, Hagen

    2015-01-01

    This paper is concerned with machine localisation of multiple active speech sources in reverberant environments using two (binaural) microphones. Such conditions typically present a problem for ‘classical’ binaural models. Inspired by the human ability to utilise head movements, the current study...

  6. Localisation vaginale de Mansonella perstans: à propos d'un cas au ...

    African Journals Online (AJOL)

    Localisation vaginale de Mansonella perstans: à propos d'un cas au centre hospitalier universitaire de Bobo-Dioulasso, Burkina Faso. Sanata Bamba, Fatou Barro-Traoré, Martine Liance, Cathy Chemla, Charles Sanou, Olo Da, Tinga Robert Guiguemdé ...

  7. Mozart's African jacket: Die Zauberflöte and its localisation in The ...

    African Journals Online (AJOL)

    , the change in time, space, context and symbolism in a localised or indigenised South African version of Mozart's Die Zauberflöte, K. 620. It addresses the lacunae between desiderata expressed in the White Paper on Arts, Culture and ...

  8. Characterisation of a novel proteolytic enzyme localised to goblet cells in rat and man

    DEFF Research Database (Denmark)

    Poulsen, Steen Seier

    1984-01-01

    A proteolytic enzyme, ingobsin , purified from rat duodenal extracts is shown to be localised to intestinal goblet cells of both man and rat. Enzyme positive cells decrease in number from duodenum to colon. The enzyme is a 33 000 Mr protein with an isoelectric point of 5.1. The pH optimum...

  9. Exploiting deep neural networks and head movements for binaural localisation of multiple speakers in reverberant conditions

    DEFF Research Database (Denmark)

    Ma, Ning; Brown, Guy J.; May, Tobias

    2015-01-01

    This paper presents a novel machine-hearing system that exploits deep neural networks (DNNs) and head movements for binaural localisation of multiple speakers in reverberant conditions. DNNs are used to map binaural features, consisting of the complete crosscorrelation function (CCF) and interaural...... acoustic scenarios in which multiple speakers and room reverberation are present....

  10. Localised and Learnt Applications of Machine Learning for Robotic Incremental Sheet Forming

    DEFF Research Database (Denmark)

    Nicholas, Paul; Zwierzycki, Mateusz; Ramsgaard Thomsen, Mette

    2017-01-01

    Sheet Forming (ISF) and exemplified in the fabrication of a bridge structure. The methods we describe compensate for springback and improve forming tolerance by using localised in-process distance sensing to adapt tool-paths, and by using pre-process supervised machine learning to predict stringback...

  11. Growth patterns in Onychophora (velvet worms: lack of a localised posterior proliferation zone

    Directory of Open Access Journals (Sweden)

    Landman Kerry A

    2010-11-01

    Full Text Available Abstract Background During embryonic development of segmented animals, body segments are thought to arise from the so-called "posterior growth zone" and the occurrence of this "zone" has been used to support the homology of segmentation between arthropods, annelids, and vertebrates. However, the term "posterior growth zone" is used ambiguously in the literature, mostly referring to a region of increased proliferation at the posterior end of the embryo. To determine whether such a localised posterior proliferation zone is an ancestral feature of Panarthropoda (Onychophora + Tardigrada + Arthropoda, we examined cell division patterns in embryos of Onychophora. Results Using in vivo incorporation of the DNA replication marker BrdU (5-bromo-2'-deoxyuridine and anti-phospho-histone H3 immunolabelling, we found that a localised posterior region of proliferating cells does not occur at any developmental stage in onychophoran embryos. This contrasts with a localised pattern of cell divisions at the posterior end of annelid embryos, which we used as a positive control. Based on our data, we present a mathematical model, which challenges the paradigm that a localised posterior proliferation zone is necessary for segment patterning in short germ developing arthropods. Conclusions Our findings suggest that a posterior proliferation zone was absent in the last common ancestor of Onychophora and Arthropoda. By comparing our data from Onychophora with those from annelids, arthropods, and chordates, we suggest that the occurrence of a "posterior growth zone" currently cannot be used to support the homology of segmentation between these three animal groups.

  12. A global FE-local analytical approach to modelling failure in localised buckles caused by crash

    NARCIS (Netherlands)

    Dekker, R.; Walters, C.L.

    2016-01-01

    Localised buckles can occur in crasheswhen compressive stresses are dominant. However, due to their local appearance, they might be overlooked by a finite element analysis, meaning that local failure due to bucklingwill not be predicted. This could, for example, be catastrophic in the case of the

  13. Non-Gaussian probabilistic MEG source localisation based on kernel density estimation☆

    Science.gov (United States)

    Mohseni, Hamid R.; Kringelbach, Morten L.; Woolrich, Mark W.; Baker, Adam; Aziz, Tipu Z.; Probert-Smith, Penny

    2014-01-01

    There is strong evidence to suggest that data recorded from magnetoencephalography (MEG) follows a non-Gaussian distribution. However, existing standard methods for source localisation model the data using only second order statistics, and therefore use the inherent assumption of a Gaussian distribution. In this paper, we present a new general method for non-Gaussian source estimation of stationary signals for localising brain activity from MEG data. By providing a Bayesian formulation for MEG source localisation, we show that the source probability density function (pdf), which is not necessarily Gaussian, can be estimated using multivariate kernel density estimators. In the case of Gaussian data, the solution of the method is equivalent to that of widely used linearly constrained minimum variance (LCMV) beamformer. The method is also extended to handle data with highly correlated sources using the marginal distribution of the estimated joint distribution, which, in the case of Gaussian measurements, corresponds to the null-beamformer. The proposed non-Gaussian source localisation approach is shown to give better spatial estimates than the LCMV beamformer, both in simulations incorporating non-Gaussian signals, and in real MEG measurements of auditory and visual evoked responses, where the highly correlated sources are known to be difficult to estimate. PMID:24055702

  14. Learning Designs Supporting Localisation for Personalised and Adaptive E-Learning

    NARCIS (Netherlands)

    Altuner, Ergin Murat; Turker, Mustafa Ali

    2006-01-01

    Please, cite this publication as: Altuner, E. M. & Türker, M. A. (2006). Learning Designs Supporting Localisation Personalised and Adaptive E-Learning. Proceedings of Adaptive Hypermedia. June, Dublin, Ireland. Retrieved June 30th, 2006, from http://dspace.learningnetworks.org

  15. Local characterisation of fluid flow in sandstone with localised deformation features through fast neutron imaging

    Directory of Open Access Journals (Sweden)

    Rowe S.

    2010-06-01

    Full Text Available Understanding fluid flow through rocks is of key interest in hydrocarbon production and CO2 sequestration, amongst other applications. Such fluid injection or extraction from subsurface reservoirs can be significantly modified (increased or decreased by deformation and in particular by localised deformation features (fractures, shear bands and compaction bands. How such deformation alters fluid flow is however not well characterised experimentally. Measurement of fluid-flow distributions throughout a specimen requires techniques that can, first, see inside a test specimen and, second, see the fluid distinctly from the solid part. Therefore, neutron absorption imaging is well adapted to fluid flow monitoring in rocks as water is largely opaque to neutrons (i.e., it is highly absorbing and rocks are generally less absorbing. In this paper we present initial results of neutron radiography monitoring of fluid-flow through samples of a sandstone containing localised deformation features (shear-bands. A comparison of flow through an intact specimen and flow through samples containing localised deformation features is presented that provides insight into the effect of localised deformation on the flow properties.

  16. Globalisation and Localisation in Music Education in Hong Kong and Taiwan

    Science.gov (United States)

    Ho, Wai-Chung

    2013-01-01

    The purpose of the study is to analyse and discuss the influences of globalisation and localisation on music education in Hong Kong and Taiwan. It argues that the reform of music education concerns changes to the contents of the curriculum that envisage the cultural and political developments that arise from processes of globalisation and…

  17. Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

    DEFF Research Database (Denmark)

    Fahrenkrug, Jan; Hannibal, Jens

    2011-01-01

    PACAP (pituitary adenylate cyclase activating polypeptide) is widely distributed neuropeptide acting via three subtypes of receptors, PAC(1), VPAC(1) and VPAC(2). Here we examined the localisation and nature of PACAP-immunoreactive nerves in the rat thyroid and parathyroid glands and defined the ...

  18. Edge instabilities of topological superconductors

    Science.gov (United States)

    Hofmann, Johannes S.; Assaad, Fakher F.; Schnyder, Andreas P.

    2016-05-01

    Nodal topological superconductors display zero-energy Majorana flat bands at generic edges. The flatness of these edge bands, which is protected by time-reversal and translation symmetry, gives rise to an extensive ground-state degeneracy. Therefore, even arbitrarily weak interactions lead to an instability of the flat-band edge states towards time-reversal and translation-symmetry-broken phases, which lift the ground-state degeneracy. We examine the instabilities of the flat-band edge states of dx y-wave superconductors by performing a mean-field analysis in the Majorana basis of the edge states. The leading instabilities are Majorana mass terms, which correspond to coherent superpositions of particle-particle and particle-hole channels in the fermionic language. We find that attractive interactions induce three different mass terms. One is a coherent superposition of imaginary s -wave pairing and current order, and another combines a charge-density-wave and finite-momentum singlet pairing. Repulsive interactions, on the other hand, lead to ferromagnetism together with spin-triplet pairing at the edge. Our quantum Monte Carlo simulations confirm these findings and demonstrate that these instabilities occur even in the presence of strong quantum fluctuations. We discuss the implications of our results for experiments on cuprate high-temperature superconductors.

  19. Domination Edge Lift Critical Trees | Desormeaux | Quaestiones ...

    African Journals Online (AJOL)

    stract. Let uxv be an induced path with center x in a graph G. The edge lifting of uv off x is defined as the action of removing edges ux and vx from the edge set of G, while adding the edge uv to the edge set of G. We study trees for which every possible edge lift changes the domination number. We show that there are no ...

  20. Professional ideals and daily practice in journalism

    DEFF Research Database (Denmark)

    Pihl-Thingvad, Signe

    2015-01-01

    of commitment, but until now these assumptions have never been empirically examined. This article provides new knowledge of the relationship between professional ideals and daily practice in journalism by describing the contours of the existing discrepancies in the generation of news in Denmark. In addition...

  1. Rabindranath Tagore's Ideals of Aesthetic Education.

    Science.gov (United States)

    Lal, Swati

    1984-01-01

    Rabindranath Tagore (1861-1941) was an Indian educator who established the Santiniketan schools, which replicated to a large extent the ashram or forest school of ancient India, where gurus and their pupils lived in a residential hermitage. Tagore's aesthetic ideals of education as manifested in the school at Santiniketan are discussed. (RM)

  2. Changing Masculinity Ideals in a Danish Context

    DEFF Research Database (Denmark)

    Bloksgaard, Lotte; Christensen, Ann-Dorte

    analysis builds on a survey conducted in the project ‘MARS’, which analyses the relation between masculinity and work-related accidents in two male dominated occupations. The survey shows that traditional masculinity ideals (the MRNI scale, Levant 2007) only find very low support (10 %) among the workers...

  3. Collective excitations of harmonically trapped ideal gases

    NARCIS (Netherlands)

    Van Schaeybroeck, B.; Lazarides, A.

    2009-01-01

    We theoretically study the collective excitations of an ideal gas confined in an isotropic harmonic trap. We give an exact solution to the Boltzmann-Vlasov equation; as expected for a single-component system, the associated mode frequencies are integer multiples of the trapping frequency. We show

  4. Quantum cryptography with an ideal local relay

    DEFF Research Database (Denmark)

    Spedalieri, Gaetana; Ottaviani, Carlo; Braunstein, Samuel L.

    2015-01-01

    We consider two remote parties connected to a relay by two quantum channels. To generate a secret key, they transmit coherent states to the relay, where the states are subject to a continuous-variable (CV) Bell detection. We study the ideal case where Alice's channel is lossless, i.e., the relay ...

  5. Idealization, Abduction, and Progressive Scientific Change

    Directory of Open Access Journals (Sweden)

    Xavier de Donato-Rodríguez

    2009-12-01

    Full Text Available After a brief comparison of Aliseda’s account with different approaches to abductive reasoning, I try to relate abduction, understood in terms like those of Aliseda, to another concept which also occupies a very important role in scientific change: idealization. In particular, I try to reveal some interesting aspects related to notions like approximation and empirical progress.

  6. Derivation of the Ideal Gas Law

    Science.gov (United States)

    Laugier, Alexander; Garai, Jozsef

    2007-01-01

    Undergraduate and graduate physics and chemistry books usually state that combining the gas laws results in the ideal gas law. Leaving the derivation to the students implies that this should be a simple task, most likely a substitution. Boyle's law, Charles's law, and the Avogadro's principle are given under certain conditions; therefore, direct…

  7. Water: The Ideal Early Learning Environment

    Science.gov (United States)

    Grosse, Susan J.

    2008-01-01

    Bathtubs and swimming pools provide the ideal learning environment for people with special needs. For young preschool children, the activities that take place through water can help them develop physical fitness, facilitate motor development, reinforce perceptual-motor ability, encourage social development, and enhance self-esteem and confidence.…

  8. Real vs. Ideal Self Discrepancy in Bulimics.

    Science.gov (United States)

    Kosak, Karen

    Bulimia is an eating disorder prevalent among young women, characterized by binge eating episodes followed by purging with subsequent depressive moods and self-deprecating thoughts. To determine whether bulimic women exhibit a greater discrepancy between their perceived and ideal selves than do nonbulimics, three samples of women were assessed.…

  9. Project IDEALS. Educational Applications of Computer Systems.

    Science.gov (United States)

    Hansen, Duncan; And Others

    This is a booklet in the Project IDEALS series which deals with the use of Educational Data Processing (EDP) systems. A section is devoted to the use of the computer in such varied school operations as the processing of student records, schedules, computer simulation, grade reports, business, student applications, cafeterias, and transportation.…

  10. Ideal Sowing Depth for Sweetgum Seed

    Science.gov (United States)

    F. T. Bonner

    1967-01-01

    This paper reports the sowing depths from which sweetgum (Liquidambar styraciflua L.) seedlings can emerge under near ideal conditions. Little is known about the seedbed conditions required for successful direct seeding of sweetgum, and the information presented here will be useful in planning field trials.

  11. Relative contributions of spatial weighting, explicit knowledge and proprioception to hand localisation during positional ambiguity.

    Science.gov (United States)

    Bellan, Valeria; Gilpin, Helen R; Stanton, Tasha R; Dagsdóttir, Lilja K; Gallace, Alberto; Lorimer Moseley, G

    2017-02-01

    When vision and proprioception are rendered incongruent during a hand localisation task, vision is initially weighted more than proprioception in determining location, and proprioception gains more weighting over time. However, it is not known whether, under these incongruency conditions, particular areas of space are also weighted more heavily than others, nor whether explicit knowledge of the sensory incongruence (i.e. disconfirming the perceived location of the hand) modulates the effect. Here, we hypothesised that both non-informative inputs coming from one side of space and explicit knowledge of sensory incongruence would modulate perceived location of the limb. Specifically, we expected spatial weighting to shift hand localisation towards the weighted area of space, and we expected greater weighting of proprioceptive input once perceived location was demonstrated to be inaccurate. We manipulated spatial weighting using an established auditory cueing paradigm (Experiment 1, n = 18) and sensory incongruence using the 'disappearing hand trick' (Experiment 2, n = 9). Our first hypothesis was not supported-spatial weighting did not modulate hand localisation. Our second hypothesis was only partially supported-disconfirmation of hand position did lead to more accurate localisations, even if participants were still unaware of their hand position. This raised the possibility that rather than disconfirmation, a simple movement of the hand in view could update the sensory-motor system, by immediately increasing the weighting of proprioceptive input relative to visual input. This third hypothesis was then confirmed (Experiment 3, n = 9). These results suggest that hand localisation is robust in the face of differential weighting of space, but open to modulation in a modality-specific manner, when one sense (vision) is rendered inaccurate.

  12. Investigation of the maximum load alleviation potential using trailing edge flaps controlled by inflow data

    DEFF Research Database (Denmark)

    Fischer, Andreas; Aagaard Madsen, Helge

    2014-01-01

    The maximum fatigue load reduction potential when using trailing edge flaps on mega-watt wind turbines was explored. For this purpose an ideal feed forward control algorithm using the relative velocity and angle of attack at the blade to control the loads was implemented. The algorithm was applied...

  13. Damage localisation and fracture propagation in granite: 4D synchrotron x-ray microtomographic observations from an in-situ triaxial deformation experiment at SOLEIL

    Science.gov (United States)

    Cartwright-Taylor, Alexis; Fusseis, Florian; Butler, Ian; Flynn, Michael; King, Andrew

    2017-04-01

    strains between time steps were quantified using 3D digital image correlation [2]. In combination, these analyses show the extent and evolution of local aseismic deformation and that related to microcracking. Our results provide direct evidence of ongoing deformation processes such as micro-fracture nucleation at pre-existing flaws, in the form of cracks, grain boundaries and pores, and coalescence of en-echelon tensile micro-fractures along a shear fault in response to changes in the local stress field. These direct 4D observations of damage evolution and strain localisation complement the seminal results of Lockner et al. [3], who first imaged the process of fault growth using acoustic emissions locations. Our data provide further insight into the aseismic mechanisms that dissipate 99% of the total accumulated strain energy [4] and the interactions between these mechanisms and the developing microcracks. Our results also provide experimental verification of models for shear fracture formation whereby pre-existing flaws become connected by en-echelon tensile cracks that extend from their edges. _________________________________________ [1] Voorn et al., 2015, J. Petroleum Sci. Eng. 127, 270-285. [2] Hall, S. et al., 2010, Geotechnique 60, 315-322. [3] Lockner, D., et al., 1991, Nature 350, 39-42. [4] Byerlee, J., 1993, Geology 21, 303-306.

  14. Linear Analysis and Verification Suite for Edge Turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Myra, J R; Umansky, M

    2008-04-24

    The edge and scrape-off-layer region of a tokamak plasma is subject to well known resistive and ideal instabilities that are driven by various curvature- and sheath-related mechanisms. While the boundary plasma is typically strongly turbulent in experiments, it is useful to have computational tools that can analyze the linear eigenmode structure, predict quantitative trends in growth rates and elucidate and the underlying drive mechanisms. Furthermore, measurement of the linear growth rate of unstable modes emerging from a known, established equilibrium configuration provides one of the few quantitative ways of rigorously benchmarking large-scale plasma turbulence codes with each other and with a universal standard. In this report, a suite of codes that can describe linearized, nonlocal (e.g. separatrix-spanning) modes in axisymmetric (realistic divertor), toroidal geometry is discussed. Examples of several benchmark comparisons are given, and future development plans for a new eigenvalue edge code are presented.

  15. Enhancing Community Detection By Affinity-based Edge Weighting Scheme

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Andy [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sanders, Geoffrey [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Henson, Van [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vassilevski, Panayot [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-05

    Community detection refers to an important graph analytics problem of finding a set of densely-connected subgraphs in a graph and has gained a great deal of interest recently. The performance of current community detection algorithms is limited by an inherent constraint of unweighted graphs that offer very little information on their internal community structures. In this paper, we propose a new scheme to address this issue that weights the edges in a given graph based on recently proposed vertex affinity. The vertex affinity quantifies the proximity between two vertices in terms of their clustering strength, and therefore, it is ideal for graph analytics applications such as community detection. We also demonstrate that the affinity-based edge weighting scheme can improve the performance of community detection algorithms significantly.

  16. On the edge: haptic discrimination of edge sharpness.

    Directory of Open Access Journals (Sweden)

    Andy L Skinner

    Full Text Available The increasing ubiquity of haptic displays (e.g., smart phones and tablets necessitates a better understanding of the perceptual capabilities of the human haptic system. Haptic displays will soon be capable of locally deforming to create simple 3D shapes. This study investigated the sensitivity of our haptic system to a fundamental component of shapes: edges. A novel set of eight high quality shape stimuli with test edges that varied in sharpness were fabricated in a 3D printer. In a two alternative, forced choice task, blindfolded participants were presented with two of these shapes side by side (one the reference, the other selected randomly from the remaining set of seven and after actively exploring the test edge of each shape with the tip of their index finger, reported which shape had the sharper edge. We used a model selection approach to fit optimal psychometric functions to performance data, and from these obtained just noticeable differences and Weber fractions. In Experiment 1, participants performed the task with four different references. With sharpness defined as the angle at which one surface meets the horizontal plane, the four JNDs closely followed Weber's Law, giving a Weber fraction of 0.11. Comparisons to previously reported Weber fractions from other haptic manipulations (e.g. amplitude of vibration suggests we are sufficiently sensitive to changes in edge sharpness for this to be of potential utility in the design of future haptic displays. In Experiment 2, two groups of participants performed the task with a single reference but different exploration strategies; one was limited to a single touch, the other unconstrained and free to explore as they wished. As predicted, the JND in the free exploration condition was lower than that in the single touch condition, indicating exploration strategy affects sensitivity to edge sharpness.

  17. The sensitivity of tokamak magnetohydrodynamics stability on the edge equilibrium

    Science.gov (United States)

    Zheng, L. J.; Kotschenreuther, M. T.; Valanju, P.

    2017-10-01

    Due to the X-point singularity, the safety factor tends to infinity as approaching to the last closed flux surface. The numerical treatments of the near X-point behavior become challenging both for equilibrium and stability. The usual solution is to cut off a small fraction of edge region for system stability evaluation or simply use an up-down symmetric equilibrium without X-point as an approximation. In this work, we assess the sensitivity of this type of equilibrium treatments on the stability calculation. It is found that the system stability can depend strongly on the safety factor value (qa) at the edge after the cutting-off. When the edge safety factor value falls in the vicinity of a rational mode number (referred to as the resonant gap), the system becomes quite unstable due to the excitation of the peeling type modes. Instead, when the edge safety factor is outside the resonant gaps, the system is much more stable and the predominant modes become the usual external kink (or ballooning and infernal) type. It is also found that the resonant gaps become smaller and smaller as qa increases. The ideal magnetohydrodynamic peeling ballooning stability diagram is widely used to explain the experimental observations, and the current results indicate that the conventional peeling ballooning stability diagram based on the simplified equilibrium needs to be reexamined.

  18. The nature of carrier localisation in polar and nonpolar InGaN/GaN quantum wells

    Energy Technology Data Exchange (ETDEWEB)

    Dawson, P., E-mail: philip.dawson@manchester.ac.uk [School of Physics and Astronomy, Photon Science Institute, University of Manchester, Manchester M13 9PL (United Kingdom); Schulz, S. [Photonics Theory Group, Tyndall National Institute, Dyke Parade, Cork (Ireland); Oliver, R. A.; Kappers, M. J.; Humphreys, C. J. [Department of Material Science and Metallurgy, 27 Charles Babbage Road, University of Cambridge, Cambridge CB3 0FS (United Kingdom)

    2016-05-14

    In this paper, we compare and contrast the experimental data and the theoretical predictions of the low temperature optical properties of polar and nonpolar InGaN/GaN quantum well structures. In both types of structure, the optical properties at low temperatures are governed by the effects of carrier localisation. In polar structures, the effect of the in-built electric field leads to electrons being mainly localised at well width fluctuations, whereas holes are localised at regions within the quantum wells, where the random In distribution leads to local minima in potential energy. This leads to a system of independently localised electrons and holes. In nonpolar quantum wells, the nature of the hole localisation is essentially the same as the polar case but the electrons are now coulombically bound to the holes forming localised excitons. These localisation mechanisms are compatible with the large photoluminescence linewidths of the polar and nonpolar quantum wells as well as the different time scales and form of the radiative recombination decay curves.

  19. Protected Edge Modes without Symmetry

    Directory of Open Access Journals (Sweden)

    Michael Levin

    2013-05-01

    Full Text Available We discuss the question of when a gapped two-dimensional electron system without any symmetry has a protected gapless edge mode. While it is well known that systems with a nonzero thermal Hall conductance, K_{H}≠0, support such modes, here we show that robust modes can also occur when K_{H}=0—if the system has quasiparticles with fractional statistics. We show that some types of fractional statistics are compatible with a gapped edge, while others are fundamentally incompatible. More generally, we give a criterion for when an electron system with Abelian statistics and K_{H}=0 can support a gapped edge: We show that a gapped edge is possible if and only if there exists a subset of quasiparticle types M such that (1 all the quasiparticles in M have trivial mutual statistics, and (2 every quasiparticle that is not in M has nontrivial mutual statistics with at least one quasiparticle in M. We derive this criterion using three different approaches: a microscopic analysis of the edge, a general argument based on braiding statistics, and finally a conformal field theory approach that uses constraints from modular invariance. We also discuss the analogous result for two-dimensional boson systems.

  20. The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.

    Science.gov (United States)

    Copsey, Alice C; Cooper, Simon; Parker, Robert; Lineham, Ella; Lapworth, Cuzack; Jallad, Deema; Sweet, Steve; Morley, Simon J

    2017-08-30

    DDX3X, a helicase, can interact directly with mRNA and translation initiation factors, regulating the selective translation of mRNAs that contain a structured 5' untranslated region. This activity modulates the expression of mRNAs controlling cell cycle progression and mRNAs regulating actin dynamics, contributing to cell adhesion and motility. Previously, we have shown that ribosomes and translation initiation factors localise to the leading edge of migrating fibroblasts in loci enriched with actively translating ribosomes, thereby promoting steady-state levels of ArpC2 and Rac1 proteins at the leading edge of cells during spreading. As DDX3X can regulate Rac1 levels, cell motility and metastasis, we have examined DDX3X protein interactions and localisation using many complementary approaches. We now show that DDX3X can physically interact and co-localise with poly(A)-binding protein 1 and caprin-1 at the leading edge of spreading cells. Furthermore, as depletion of DDX3X leads to decreased cell motility, this provides a functional link between DDX3X, caprin-1 and initiation factors at the leading edge of migrating cells to promote cell migration and spreading. © 2017 The Author(s).

  1. On multiphase negative flash for ideal solutions

    DEFF Research Database (Denmark)

    Yan, Wei; Stenby, Erling Halfdan

    2012-01-01

    There is a recent interest to solve multiphase negative flash problems where the phase amounts can be negative for normal positive feed composition. Solving such a negative flash problem using successive substitution needs an inner loop for phase distribution calculation at constant fugacity...... coefficients. It is shown that this inner loop, named here as multiphase negative flash for ideal solutions, can be solved either by Michelsen's algorithm for multiphase normal flash, or by its variation which uses F−1 phase amounts as independent variables. In either case, the resulting algorithm is actually...... simpler than the corresponding normal flash algorithm. Unlike normal flash, multiphase negative flash for ideal solutions can diverge if the feasible domain for phase amounts is not closed. This can be judged readily during the iteration process. The algorithm can also be extended to the partial negative...

  2. A New Perspective on Classical Ideal Gases

    Directory of Open Access Journals (Sweden)

    Fabrice Philippe

    2013-08-01

    Full Text Available The ideal-gas barometric and pressure laws are derived from the Democritian concept of independent corpuscles moving in vacuum, plus a principle of simplicity, namely that these laws are independent of the kinetic part of the Hamiltonian. A single corpuscle in contact with a heat bath in a cylinder and submitted to a constant force (weight is considered. The paper importantly supplements a previously published paper: First, the stability of ideal gases is established. Second, we show that when walls separate the cylinder into parts and are later removed, the entropy is unaffected. We obtain full agreement with Landsberg’s and others’ (1994 classical thermodynamic result for the entropy of a column of gas submitted to gravity.

  3. All-graphene edge contacts

    DEFF Research Database (Denmark)

    Jacobsen, Kåre Wedel; Falkenberg, Jesper Toft; Papior, Nick Rübner

    2016-01-01

    Using ab-initio methods we investigate the possibility of three-terminalgraphene "T-junction" devices and show that these all-graphene edge contactsare energetically feasible when the 1D interface itself is free from foreignatoms. We examine the energetics of various junction structures as a func......Using ab-initio methods we investigate the possibility of three-terminalgraphene "T-junction" devices and show that these all-graphene edge contactsare energetically feasible when the 1D interface itself is free from foreignatoms. We examine the energetics of various junction structures...... to be in therange of 1-10 kΩμm which is comparable to the best contact resistance reportedfor edge-contacted graphene-metal contacts. We conclude that conductingall-carbon T-junctions should be feasible....

  4. Ideal family population In a rural Tswana

    African Journals Online (AJOL)

    1983-04-09

    Apr 9, 1983 ... s'tay the same. At present one can only speculate that as the pe~plegrow older they may well regard a slightly bigger family as ideal, but it is unlikely that they will aspire to quite such large families as their elders do now. The traditional impression among Blacks is that Black men want more children than do ...

  5. Mellem bureaukrati, klient og professionelle idealer

    DEFF Research Database (Denmark)

    Sandholm Larsen, Niels; Johnsen, Helle; Larsen, Kristian

    2015-01-01

    Between Bureaucracy, Clients and Professional Ideals – a Sociological Approach to Midwifes Experiences Monitoring Fetal Heartbeat Using Different Technologies. This article examines professionals’ perspectives on shifts in status of technologies. The article builds on data from focus group...... interviews with Danish midwives. Interviews revolve around midwives experiences using two technologies to listen to fetal heartbeat, the classical Pinard and the electronic Sonic Aid. These technologies are presently questioned by the Danish health authorities as well as obstetric research, due...

  6. Mellem bureaukrati, klient og professionelle idealer

    DEFF Research Database (Denmark)

    Sandholm, Niels; Johnsen, Helle; Larsen, Kristian

    2015-01-01

    Between Bureaucracy, Clients and Professional Ideals – a Sociological Approach to Midwifes’ Experiences Monitoring Fetal Heartbeat Using Different Technologies. This article examines professionals’ perspectives on shifts in status of technologies. The article builds on data from focus group...... interviews with Danish midwives. Interviews revolve around midwives experiences using two technologies to listen to fetal heartbeat, the classical Pinard and the electronic Sonic Aid. These technologies are presently questioned by the Danish health authorities as well as obstetric research, due...

  7. Redefining the Ideal Buttocks: A Population Analysis.

    Science.gov (United States)

    Wong, Wendy W; Motakef, Saba; Lin, Yi; Gupta, Subhas C

    2016-06-01

    The buttocks are a key element of female beauty, with aesthetic gluteoplasty becoming one of the fastest growing plastic surgery procedures. However, there remains no clear standard for the ideal buttocks. The authors performed a population analysis of the characteristics of the ideal buttocks to guide surgical planning. Images of buttocks were digitally altered to create buttocks of varying proportions on posterior and lateral views. Waist-to-hip ratios and varying vertical proportions were studied. Data were stratified and analyzed according to age range, gender, ethnicity, and nationality of the respondents. A total of 1146 responses were collected. Of 989 respondents who submitted their gluteal preferences, 482 respondents (48.7 percent) were women and 507 (51.3 percent) were men. Overall, the most attractive buttocks waist-to-hip ratio is 0.65 from the posterior view (44.2 percent of respondents). The next most attractive ratio was 0.60 (25 percent of respondents). Positioning of the lateral prominence at the inferior gluteal fold was rated by 26.3 percent of respondents as the most attractive. From the lateral view, the most attractive buttocks have a waist-to-hip ratio of 0.70 (29.8 percent of respondents), with the most prominent portion positioned at the midpoint of the buttocks (45.1 percent of respondents), which is a 50:50 vertical ratio. There were no significant differences in preferences between respondent ages, genders, or ethnicities. New ideal waist-to-hip ratios of 0.6 and 0.65 update the previous standards and indicate a more dramatic and "curvier" new ideal, signaling an important preference paradigm shift. The information derived from this study has the potential to guide gluteoplasty practices and techniques.

  8. Flujo de potencia en un transformador ideal

    OpenAIRE

    Delgado, Alberto

    1986-01-01

    En el siguiente trabajo, se estudia el transformador ideal desde el punto de vista de flujo de potencia, es decir, la forma como la potencia se transfiere del primario al secundario por medio del campo electromagnético existente en el núcleo; además se tratará el comportamiento de esta máquina a los tres tipos fundamentales de carga.

  9. A non-ideal global basic structure

    Directory of Open Access Journals (Sweden)

    Sabrina Martin

    2016-10-01

    Full Text Available Focusing on the basic structure as the subject of justice has tended to lead theorists to make a choice: either there is no global basic structure and therefore obligations of justice remain domestic only (the statist position or there is sufficient institutional basis at the global level to warrant affirming a basic structure global in scope, meaning that duties of justice must also be global (the cosmopolitan position. Recent literature, however, has pointed out that this might be a false choice between denying and asserting the existence of a global basic structure. There are two main claims that I make in this paper. First, I claim that on a Rawlsian understanding of the basic structure, justice does not require one before its demands arise, but rather that under certain conditions, justice can require that a basic structure be established as an essential part of fulfilling its demands. This has the benefit of not restricting the scope of justice to the domestic sphere. Thus, the second claim is about determining, from a practice-dependent, non-ideal starting point, what those “certain conditions” are. Specifically, I argue that when currently existing global institutions begin impacting on the freedom of individuals to interact against a fair backdrop and pervasively impact on life chances, then the demands of justice will arise and we will need to establish a global basic structure. This paper, then, also has implications for the ideal/non-ideal theory debate, because I argue that the best way to globalize the basic structure is to begin from a non-ideal starting point.Article first published online: 9 NOV 2015

  10. Preserving idealism in global health promotion.

    Science.gov (United States)

    Franco-Paredes, Carlos; Zeuli, Julia; Hernández-Ramos, Isabel; Santos-Preciado, Jose I

    2010-12-01

    If the field of global health is to evolve in the second decade of the new millennium, we need to revive the idealistic spirit and by using the lens of health equity work toward improved health status around the world. Morality and empathy are considered by-products of our evolutionary history as a human species. Idealism may be a trait that we may choose to preserve in our modern evolutionary history.

  11. Maximally differential ideals in regular local rings

    Indian Academy of Sciences (India)

    Introduction. Let (A, m) be a Noetherian local ring and let I be an ideal in A. Assume that I is maxi- mally differential under a set of derivations of A. Then A/I contains a field k. If k is of characteristic p > 0 then the structure of A/I is given by Harper's theorem [4] (see [7] for a proof). Assume now that A/I contains a field of ...

  12. The Ideal Man and Woman According to University Students

    Science.gov (United States)

    Weinstein, Lawrence; Laverghetta, Antonio V.; Peterson, Scott A.

    2009-01-01

    The present study determined if the ideal man has changed over the years and who and what the ideal woman is. We asked students at Cameron University to rate the importance of character traits that define the ideal man and woman. Subjects also provided examples of famous people exemplifying the ideal, good, average, and inferior man and woman. We…

  13. A model of the ideal molecular surface

    Science.gov (United States)

    Henson, Bryan; Smilowitz, Laura

    2014-03-01

    We utilize two manifestations of the phenomena of the quasiliquid phase on the surface of molecular crystals to formulate a universal thermodynamic theory describing the thickness of the layer as a function of the liquid phase activity. We use direct measurements of the liquid thickness as a function of temperature and measurements of the acceleration of thermal decomposition as a function of temperature approaching the melting point to illustrate the mechanism. We show that given the existence of a liquid phase below the melting point the ideal liquid activity is necessarily a fixed function of the free energies of sublimation and vaporization. We use this activity to create a reduced formula for the liquid thickness generally applicable to the molecular surface. We provide a prediction of the mechanism and kinetics of quasiliquid formation and show that the phase exists as a metastable kinetic steady state. We show that to first order the principle controlling feature of the system is the configurational entropy of the liquid/solid interface, rather than the specifics of the surface potential energy. This is analogous to other bulk colligative phenomena such as ideal gas and solution theories, and is thus an ideal, universal formulation of inherent, thermodynamically driven, surface disorder.

  14. Non-Ideal Behavior in Solvent Extraction

    Energy Technology Data Exchange (ETDEWEB)

    Peter Zalupski

    2011-09-01

    This report presents a summary of the work performed to meet FCR&D level 3 milestone M31SW050801, 'Complete the year-end report summarizing FY11 experimental and modeling activities.' This work was carried out under the auspices of the Non-Ideality in Solvent Extraction Systems FCR&D work package. The report summarizes our initial considerations of potential influences that non-ideal chemistry may impose on computational prediction of outcomes in solvent extraction systems. The report is packaged into three separate test cases where a robustness of the prediction by SXFIT program is under scrutiny. The computational exercises presented here emphasize the importance of accurate representation of both an aqueous and organic mixtures when modeling liquid-liquid distribution systems. Case No.1 demonstrates that non-ideal behavior of HDEHP in aliphatic diluents, such as n-dodecane, interferes with the computation. Cases No.2 and No.3 focus on the chemical complexity of aqueous electrolyte mixtures. Both exercises stress the need for an improved thermodynamic model of an aqueous environment present in the europium distribution experiments. Our efforts for year 2 of this project will focus on the improvements of aqueous and non-aqueous solution models using fundamental physical properties of mixtures acquired experimentally in our laboratories.

  15. Finding edges in noisy scenes

    Science.gov (United States)

    Machuca, R.; Gilbert, A. L.

    1981-01-01

    Edge detection in the presence of noise is a well-known problem. This paper examines an applications-motivated approach for solving the problem using novel techniques and presents a method developed by the authors that performs well on a large class of targets. ROC curves are used to compare this method with other well-known edge detection operators, with favorable results. A theoretical argument is presented that favors LMMSE filtering over median filtering in extremely noisy scenes. Simulated results of the research are presented.

  16. Edge enhanced morphology for infrared image analysis

    Science.gov (United States)

    Bai, Xiangzhi; Liu, Haonan

    2017-01-01

    Edge information is one of the critical information for infrared images. Morphological operators have been widely used for infrared image analysis. However, the edge information in infrared image is weak and the morphological operators could not well utilize the edge information of infrared images. To strengthen the edge information in morphological operators, the edge enhanced morphology is proposed in this paper. Firstly, the edge enhanced dilation and erosion operators are given and analyzed. Secondly, the pseudo operators which are derived from the edge enhanced dilation and erosion operators are defined. Finally, the applications for infrared image analysis are shown to verify the effectiveness of the proposed edge enhanced morphological operators. The proposed edge enhanced morphological operators are useful for the applications related to edge features, which could be extended to wide area of applications.

  17. Border bases and order ideals: a polyhedral characterization

    OpenAIRE

    Braun, Gábor; Pokutta, Sebastian

    2009-01-01

    Border bases arise as a canonical generalization of Gr\\"obner bases. We provide a polyhedral characterization of all order ideals (and hence border bases) that are supported by a zero-dimensional ideal: order ideals that support a border basis correspond one-to-one to integral points of the order ideal polytope. In particular, we establish a crucial connection between the ideal and its combinatorial structure. Based on this characterization we adapt the classical border basis algorithm to all...

  18. Survival after radical prostatectomy for clinically localised prostate cancer: a population-based study

    DEFF Research Database (Denmark)

    Røder, MA; Brasso, K; Christensen, IJ

    2014-01-01

    hazard of all-cause and prostate cancer-specific mortality after 10 years was 15.4% (95% confide3nce interval [CI] 13.2-17.7) and 6.6% (95% CI 4.9-8.2) respectively. CONCLUSIONS: We present the first survival analysis of a complete, nationwide cohort of men undergoing RP for localised prostate cancer......OBJECTIVES: To describe survival and cause of death in a nationwide cohort of Danish patients with prostate cancer undergoing radical prostatectomy (RP). To describe risk factors associated with prostate cancer mortality. PATIENTS AND METHODS: Observational study of 6489 men with localised prostate...... cancer treated with RP at six different hospitals in Denmark between 1995 and 2011. Survival was described using Kaplan-Meier estimates. Causes of death were obtained from the national registry and cross-checked with patient files. Cumulative incidence of death, any cause and prostate cancer...

  19. Photon counting imaging and centroiding with an electron-bombarded CCD using single molecule localisation software

    Energy Technology Data Exchange (ETDEWEB)

    Hirvonen, Liisa M.; Barber, Matthew J.; Suhling, Klaus, E-mail: klaus.suhling@kcl.ac.uk

    2016-06-01

    Photon event centroiding in photon counting imaging and single-molecule localisation in super-resolution fluorescence microscopy share many traits. Although photon event centroiding has traditionally been performed with simple single-iteration algorithms, we recently reported that iterative fitting algorithms originally developed for single-molecule localisation fluorescence microscopy work very well when applied to centroiding photon events imaged with an MCP-intensified CMOS camera. Here, we have applied these algorithms for centroiding of photon events from an electron-bombarded CCD (EBCCD). We find that centroiding algorithms based on iterative fitting of the photon events yield excellent results and allow fitting of overlapping photon events, a feature not reported before and an important aspect to facilitate an increased count rate and shorter acquisition times.

  20. Particle Filter Design Using Importance Sampling for Acoustic Source Localisation and Tracking in Reverberant Environments

    Directory of Open Access Journals (Sweden)

    Williamson Robert C

    2006-01-01

    Full Text Available Sequential Monte Carlo methods have been recently proposed to deal with the problem of acoustic source localisation and tracking using an array of microphones. Previous implementations make use of the basic bootstrap particle filter, whereas a more general approach involves the concept of importance sampling. In this paper, we develop a new particle filter for acoustic source localisation using importance sampling, and compare its tracking ability with that of a bootstrap algorithm proposed previously in the literature. Experimental results obtained with simulated reverberant samples and real audio recordings demonstrate that the new algorithm is more suitable for practical applications due to its reinitialisation capabilities, despite showing a slightly lower average tracking accuracy. A real-time implementation of the algorithm also shows that the proposed particle filter can reliably track a person talking in real reverberant rooms.

  1. Particle Filter Design Using Importance Sampling for Acoustic Source Localisation and Tracking in Reverberant Environments

    Science.gov (United States)

    Lehmann, Eric A.; Williamson, Robert C.

    2006-12-01

    Sequential Monte Carlo methods have been recently proposed to deal with the problem of acoustic source localisation and tracking using an array of microphones. Previous implementations make use of the basic bootstrap particle filter, whereas a more general approach involves the concept of importance sampling. In this paper, we develop a new particle filter for acoustic source localisation using importance sampling, and compare its tracking ability with that of a bootstrap algorithm proposed previously in the literature. Experimental results obtained with simulated reverberant samples and real audio recordings demonstrate that the new algorithm is more suitable for practical applications due to its reinitialisation capabilities, despite showing a slightly lower average tracking accuracy. A real-time implementation of the algorithm also shows that the proposed particle filter can reliably track a person talking in real reverberant rooms.

  2. Aesthetic Proximity: the Role of Stylistic Programme Elements in Format Localisation

    Directory of Open Access Journals (Sweden)

    Jolien van Keulen

    2016-08-01

    Full Text Available Implications of the transnationalisation of television are often studied by focusing on the localisation of the content of formatted programmes. Although television is essentially an audio-visual medium, little attention has been paid to the aesthetic aspects of television texts in relation to transnationalisation and formatting. Transnationalisation of production practices, such as through formatting, implies a transnational aesthetic. At the same time, aspects of style are specific to place, culture or audience. In this article, the localisation of stylistic programme elements is explored using a comparison of two reality format adaptations. It is argued that style plays an important role in the expression of the local in a transnational industry.

  3. Critical Factors in Transnational Oil Companies Localisation Decisions - Clusters and Portfolio Optimisation

    Energy Technology Data Exchange (ETDEWEB)

    Kind, Hans Jarle; Osmundsen, Petter; Tverteraas, Ragnar

    2001-10-01

    Enhanced understanding of the factors determining transnational companies' localisation decisions is important for regulators and other stakeholders concerned about maintaining current activity levels in a petroleum producing country. This article discusses localisation decisions in the context of theories of industrial clusters and real portfolio optimisation theory (materiality), which we argue are two fruitful lines of explanation for transnational companies' behaviour. The industrial cluster literature is concerned about the level of positive externalities associated with geographic clustering of related production activities. The concept of materiality, implying that investment projects in an oil province must be of a certain minimum size in order to be interesting for oil companies, is evaluated empirically and compared to predictions of mainstream economic theory. (author)

  4. Specificity of fast perceptual learning in shape localisation tasks based on detection versus form discrimination.

    Science.gov (United States)

    Kraft, Antje; Grimsen, Cathleen; Trenner, Dennis; Kehrer, Stefanie; Lipfert, Anika; Köhnlein, Martin; Fahle, Manfred; Brandt, Stephan A

    2010-02-22

    Perceptual learning is defined as a long-lasting improvement of perception as a result of experience. Here we examined the role of task on fast perceptual learning for shape localisation either in simple detection or based on form discrimination in different visual submodalities, using identical stimulus position and stimulus types for both tasks. Thresholds for each submodality were identified by four-alternative-forced-choice tasks. Fast perceptual learning occurred for shape detection-based on luminance, motion and color differences but not for texture differences. In contradistinction, fast perceptual learning was not evident in shape localisation based on discrimination. Thresholds of all submodalities were stable across days. Fast perceptual learning seems to differ not only between different visual submodalities, but also across different tasks within the same visual submodality. Copyright 2009 Elsevier Ltd. All rights reserved.

  5. The Nuclear Protein Database (NPD): sub-nuclear localisation and functional annotation of the nuclear proteome

    Science.gov (United States)

    Dellaire, G.; Farrall, R.; Bickmore, W.A.

    2003-01-01

    The Nuclear Protein Database (NPD) is a curated database that contains information on more than 1300 vertebrate proteins that are thought, or are known, to localise to the cell nucleus. Each entry is annotated with information on predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. In addition, information on the sub-nuclear localisation of each protein is provided and the biological and molecular functions are described using Gene Ontology (GO) terms. The database is searchable by keyword, protein name, sub-nuclear compartment and protein domain/motif. Links to other databases are provided (e.g. Entrez, SWISS-PROT, OMIM, PubMed, PubMed Central). Thus, NPD provides a gateway through which the nuclear proteome may be explored. The database can be accessed at http://npd.hgu.mrc.ac.uk and is updated monthly. PMID:12520015

  6. The Nuclear Protein Database (NPD): sub-nuclear localisation and functional annotation of the nuclear proteome.

    Science.gov (United States)

    Dellaire, G; Farrall, R; Bickmore, W A

    2003-01-01

    The Nuclear Protein Database (NPD) is a curated database that contains information on more than 1300 vertebrate proteins that are thought, or are known, to localise to the cell nucleus. Each entry is annotated with information on predicted protein size and isoelectric point, as well as any repeats, motifs or domains within the protein sequence. In addition, information on the sub-nuclear localisation of each protein is provided and the biological and molecular functions are described using Gene Ontology (GO) terms. The database is searchable by keyword, protein name, sub-nuclear compartment and protein domain/motif. Links to other databases are provided (e.g. Entrez, SWISS-PROT, OMIM, PubMed, PubMed Central). Thus, NPD provides a gateway through which the nuclear proteome may be explored. The database can be accessed at http://npd.hgu.mrc.ac.uk and is updated monthly.

  7. Robust self-localisation and navigation based on hippocampal place cells.

    Science.gov (United States)

    Strösslin, Thomas; Sheynikhovich, Denis; Chavarriaga, Ricardo; Gerstner, Wulfram

    2005-11-01

    A computational model of the hippocampal function in spatial learning is presented. A spatial representation is incrementally acquired during exploration. Visual and self-motion information is fed into a network of rate-coded neurons. A consistent and stable place code emerges by unsupervised Hebbian learning between place- and head direction cells. Based on this representation, goal-oriented navigation is learnt by applying a reward-based learning mechanism between the hippocampus and nucleus accumbens. The model, validated on a real and simulated robot, successfully localises itself by recalibrating its path integrator using visual input. A navigation map is learnt after about 20 trials, comparable to rats in the water maze. In contrast to previous works, this system processes realistic visual input. No compass is needed for localisation and the reward-based learning mechanism extends discrete navigation models to continuous space. The model reproduces experimental findings and suggests several neurophysiological and behavioural predictions in the rat.

  8. Numerical modelling of bifurcation and localisation in cohesive-frictional materials

    Science.gov (United States)

    de Borst, René

    1991-12-01

    Methods are reviewed for analysing highly localised failure and bifurcation modes in discretised mechanical systems as typically arise in numerical simulations of failure in soils, rocks, metals and concrete. By the example of a plane-strain biaxial test it is shown that strain softening and lack of normality in elasto-plastic constitutive equations and the ensuing loss of ellipticity of the governing field equations cause a pathological mesh dependence of numerical solutions for such problems, thus rendering the results effectively meaningless. The need for introduction of higher-order continuum models is emphasised to remedy this shortcoming of the conventional approach. For one such a continuum model, namely the unconstrained Cosserat continuum, it is demonstrated that meaningful and convergent solutions (in the sense that a finite width of the localisation zone is computed upon mesh refinement) can be obtained.

  9. Localisation of lung cancer by a radiolabelled monoclonal antibody against the c-myc oncogene product.

    Science.gov (United States)

    Chan, S. Y.; Evan, G. I.; Ritson, A.; Watson, J.; Wraight, P.; Sikora, K.

    1986-01-01

    A set of mouse nonoclonal antibodies against the c-myc oncogene product, a 62,000 dalton nuclear binding protein involved in cell cycle control, has been constructed by immunisation with synthetic peptide fragments. One such antibody, CT14, was radiolabelled with 131I and administered to 20 patients with different malignant diseases. Good tumour localisation was observed in 12 out of 14 patients with primary bronchial carcinoma but not in patients with pulmonary metastases from primary tumours elsewhere. Successfully localised tumours were all 3 cm or more in diameter. Monoclonal antibodies against oncogene products may provide novel selective tools for the diagnosis and therapy of cancer. Images Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 PMID:3801273

  10. Diffraction at a Straight Edge

    Indian Academy of Sciences (India)

    IAS Admin

    teaching and understanding physics. The simplest problem in diffraction – light pass- ing a straight edge – did not receive a rigorous solution till Sommerfeld's .... the English and. French nations. Around the same time, Young in England gave a dif- ferent formulation in which the original wave falling on the screen travels ...

  11. Morpho (?) phono (?) logical fuzzy edges

    African Journals Online (AJOL)

    Open Access DOWNLOAD FULL TEXT Subscription or Fee Access. Morpho (?) phono (?) logical fuzzy edges: The case of {-/}/{-/U/} semantic (?) contrast in Shona. K. G. Mkangwanwi. Abstract. (ZAMBEZIA: Journal of Humanities of the Univ of Zimbabwe, 2000 27(1): 47-54). Full Text: EMAIL FULL TEXT EMAIL FULL TEXT

  12. On the Edge of Existence

    DEFF Research Database (Denmark)

    Richter, Line

    2016-01-01

    Based on ethnographic fieldwork among Malian migrants and migration brokers in Mali, Algeria, Morocco, and France, this article investigates life in exile on the edge of Europe. Zooming in on the experiences of interlocutors in Morocco and Algeria, the article will explore the experiential...

  13. Case report: aesthetic management of a localised periodontal defect with a gingival veneer prosthesis.

    Science.gov (United States)

    Ellis, S G; Sharma, P; Harris, I R

    2000-03-01

    Traditionally acrylic resin gingival veneer prostheses have been used to disguise aesthetic deficiencies of maxillary anterior teeth following successful periodontal therapy and have been retained by engaging horizontal undercuts distal to the canine teeth. They are, however, versatile prostheses with uses in fixed and removable prosthodontics and therapeutic treatment of gingival conditions. In the case presented a small acrylic resin gingival veneer prosthesis retained by a resilient lining material was used to manage a localised periodontal defect of the mandibular central incisor teeth.

  14. Numerical simulation of solitary blood waves in an elastic tube subjected to a localised deformation

    Science.gov (United States)

    Ntchantcho, R.; Noubissie, S.; Woafo, P.

    2007-12-01

    In order to well apprehend what really happens in a locally deformed elastic tube, a numerical analysis of the liquid flow in such a media has been undertaken. A cylindrical tube with constant rigidity subjected to a localised dilatation is first considered and results obtained help to understand the behaviour and the developing process of aneurysm. The analysis of the effects of stenoses on blood flow is also done.

  15. Ureteric angioplasty balloon placement to increase localised dosage of BCG for renal pelvis TCC.

    LENUS (Irish Health Repository)

    Forde, J C

    2012-03-01

    Endoscopic percutaneous resection of a renal pelvis transitional cell carcinoma (TCC) is a viable treatment option in those who would be rendered dialysis dependent following a nephroureterectomy. We report endoscopic percutaneous resection of an upper tract TCC recurrence in a single functioning kidney followed by antegrade renal pelvis BCG instillation with novel placement of inflated angioplasty balloon in the ureter to help localise its effect.

  16. Auditory localisation of conventional and electric cars : laboratory results and implications for cycling safety.

    OpenAIRE

    Stelling-Konczak, A. & Hagenzieker, M.P.

    2016-01-01

    When driven at low speeds, cars operating in electric mode have been found to be quieter than conventional cars. As a result, the auditory cues which pedestrians and cyclists use to assess the presence, proximity and location oncoming traffic may be reduced, posing a safety hazard. This laboratory study examined auditory localisation of conventional and electric cars including vehicle motion paths relevant for cycling activity. Participants (N = 65) in three age groups (16–18, 30–40 and 65–70...

  17. Supporting AUV localisation through next generation underwater acoustic networks: results from the field

    Science.gov (United States)

    2016-12-01

    LEONARD, J. J. Consistent cooperative localization. In Proceedings of the IEEE International Conference on Robotics and Automation (Kobe, Japan , May...Intelligent Robots and Systems (IROS) Daejeon Convention Center October 9-14, 2016, Daejeon, Korea 978-1-5090-3761-2/16/$31.00 ©2016 IEEE 1328 is independent...a great deal of effort has been put in distributed multi- robot localisation algorithms for underwater scenarios. In [2] consistent cooperative

  18. Novel maximum likelihood approach for passive detection and localisation of multiple emitters

    Science.gov (United States)

    Hernandez, Marcel

    2017-12-01

    In this paper, a novel target acquisition and localisation algorithm (TALA) is introduced that offers a capability for detecting and localising multiple targets using the intermittent "signals-of-opportunity" (e.g. acoustic impulses or radio frequency transmissions) they generate. The TALA is a batch estimator that addresses the complex multi-sensor/multi-target data association problem in order to estimate the locations of an unknown number of targets. The TALA is unique in that it does not require measurements to be of a specific type, and can be implemented for systems composed of either homogeneous or heterogeneous sensors. The performance of the TALA is demonstrated in simulated scenarios with a network of 20 sensors and up to 10 targets. The sensors generate angle-of-arrival (AOA), time-of-arrival (TOA), or hybrid AOA/TOA measurements. It is shown that the TALA is able to successfully detect 83-99% of the targets, with a negligible number of false targets declared. Furthermore, the localisation errors of the TALA are typically within 10% of the errors generated by a "genie" algorithm that is given the correct measurement-to-target associations. The TALA also performs well in comparison with an optimistic Cramér-Rao lower bound, with typical differences in performance of 10-20%, and differences in performance of 40-50% in the most difficult scenarios considered. The computational expense of the TALA is also controllable, which allows the TALA to maintain computational feasibility even in the most challenging scenarios considered. This allows the approach to be implemented in time-critical scenarios, such as in the localisation of artillery firing events. It is concluded that the TALA provides a powerful situational awareness aid for passive surveillance operations.

  19. An efficient approach to node localisation and tracking in wireless sensor networks

    CSIR Research Space (South Africa)

    Mwila, MK

    2014-12-01

    Full Text Available algorithm is implemented in Matlab. Simulation results show that the proposed approach increases the accuracy of existing methods using RSSI by up to 59%. Index Terms—Antenna Radiation Pattern, Node Localisation, Sensor Data Fusion, Gauss-Newton Optimisation... radiation patterns are proposed to provide an initial estimate from which the final position can be refined in few steps using an optimisation method such as the Gauss-Newton method. Globecom 2014 - Ad Hoc and Sensor Networking Symposium 978...

  20. Evaluating ALWadHA for providing secure localisation for wireless sensor networks

    CSIR Research Space (South Africa)

    Abu-Mahfouz, Adnan M

    2013-09-01

    Full Text Available estimation. Because of the strong relationship between them, any of these components can be targeted by an attack on a localisation system, making these systems very fragile and hard to secure [1]. Different approaches can be used for distance... in a 200m x 200m field. A. Dishonest Reference Nodes Four malicious nodes were distributed randomly in the network. These malicious nodes pretended to be honest references and sent incorrect location references. The error of their location...

  1. Increased body satisfaction after exposure to thin ideal children's television in young girls showing thin ideal internalisation.

    Science.gov (United States)

    Anschutz, Doeschka J; Engels, Rutger C M E; Van Strien, Tatjana

    2012-01-01

    This study tested the direct effect of watching thin ideal children's television on body satisfaction in preadolescent girls (6-8 years old). A within-subject design was used in which girls (N = 51) were tested three times. They watched television clips in random order containing either (1) thin ideal animated characters or (2) animated characters with no thin ideal features or (3) 'real' human actors with no thin ideal features. After watching, their state body satisfaction was measured. Girls with higher levels of thin ideal internalisation showed higher body satisfaction after exposure to the thin ideal characters than after exposure to animated or real characters featuring no thin ideal features. No differences on body satisfaction between the exposure conditions were found in girls with lower levels of thin ideal internalisation. The results might suggest that young girls who internalised the thin ideal are inspired by thin ideal characters in children's media.

  2. The impact of bladder preparation protocols on post treatment toxicity in radiotherapy for localised prostate cancer patients

    Directory of Open Access Journals (Sweden)

    Yat Man Tsang

    2017-09-01

    Conclusion: The empty bladder preparation approach has non-inferior acute and intermediate post RT GI and GU toxicities in patients treated for localised prostate cancer with advanced radiotherapy techniques compared to the full bladder preparation.

  3. A genome-wide resource for the analysis of protein localisation in Drosophila

    Science.gov (United States)

    Sarov, Mihail; Barz, Christiane; Jambor, Helena; Hein, Marco Y; Schmied, Christopher; Suchold, Dana; Stender, Bettina; Janosch, Stephan; KJ, Vinay Vikas; Krishnan, RT; Krishnamoorthy, Aishwarya; Ferreira, Irene RS; Ejsmont, Radoslaw K; Finkl, Katja; Hasse, Susanne; Kämpfer, Philipp; Plewka, Nicole; Vinis, Elisabeth; Schloissnig, Siegfried; Knust, Elisabeth; Hartenstein, Volker; Mann, Matthias; Ramaswami, Mani; VijayRaghavan, K; Tomancak, Pavel; Schnorrer, Frank

    2016-01-01

    The Drosophila genome contains >13000 protein-coding genes, the majority of which remain poorly investigated. Important reasons include the lack of antibodies or reporter constructs to visualise these proteins. Here, we present a genome-wide fosmid library of 10000 GFP-tagged clones, comprising tagged genes and most of their regulatory information. For 880 tagged proteins, we created transgenic lines, and for a total of 207 lines, we assessed protein expression and localisation in ovaries, embryos, pupae or adults by stainings and live imaging approaches. Importantly, we visualised many proteins at endogenous expression levels and found a large fraction of them localising to subcellular compartments. By applying genetic complementation tests, we estimate that about two-thirds of the tagged proteins are functional. Moreover, these tagged proteins enable interaction proteomics from developing pupae and adult flies. Taken together, this resource will boost systematic analysis of protein expression and localisation in various cellular and developmental contexts. DOI: http://dx.doi.org/10.7554/eLife.12068.001 PMID:26896675

  4. Strictly localised triplet dimers on one- and two-dimensional lattices

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, S; Samson, J H, E-mail: s.jackson3@lboro.ac.uk, E-mail: j.h.samson@lboro.ac.uk [Department of Physics, Loughborough University, Loughborough, LE11 3TU (United Kingdom)

    2011-03-01

    Electrons may form inter-site pairs (dimers) by a number of mechanisms. For example, long-range (Froehlich) electron-phonon interactions and strong on-site Hubbard U allow formation of small light bipolarons in some lattices. We identify circumstances under which triplet dimers are strictly localised by interference in certain one- and two-dimensional lattices. We assume a U-V Hamiltonian with nearest- and next-nearest-neighbour hopping integrals t and t', large positive U and attractive nearest- and next-nearest-neighbour interactions V and V'. In the square ladder and some two-dimensional bilayers, if the dimer Hilbert space is restricted to nearest- and next-nearest-neighbour dimers, triplet dimers become strictly localised for certain values of these parameters. For example, in a square ladder with t' t and V' = V, all triplet bands become flat due to exact cancellation of hopping paths. We identify the localised eigenstates for all flat bands in each lattice. We show that many of the flat bands persist for arbitrary t/t' so long as other restrictions still apply.

  5. Localised Nonlinear Waves in the Three-Component Coupled Hirota Equations

    Science.gov (United States)

    Xu, Tao; Chen, Yong

    2017-10-01

    We construct the Lax pair and Darboux transformation for the three-component coupled Hirota equations including higher-order effects such as third-order dispersion, self-steepening, and stimulated Raman scattering. A special vector solution of the Lax pair with 4×4 matrices for the three-component Hirota system is elaborately generated, based on this vector solution, various types of mixed higher-order localised waves are derived through the generalised Darboux transformation. Instead of considering various arrangements of the three potential functions q1, q2, and q3, here, the same combination is considered as the same type solution. The first- and second-order localised waves are mainly discussed in six mixed types: (1) the hybrid solutions degenerate to the rational ones and three components are all rogue waves; (2) two components are hybrid solutions between rogue wave (RW) and breather (RW+breather), and one component is interactional solution between RW and dark soliton (RW+dark soliton); (3) two components are RW+dark soliton, and one component is RW+bright soliton; (4) two components are RW+breather, and one component is RW+bright soliton; (5) two components are RW+dark soliton, and one component is RW+bright soliton; (6) three components are all RW+breather. Moreover, these nonlinear localised waves merge with each other by increasing the absolute values of two free parameters α, β. These results further uncover some striking dynamic structures in the multicomponent coupled system.

  6. Reliability of horizontal and vertical tube shift techniques in the localisation of supernumerary teeth.

    Science.gov (United States)

    Mallineni, S K; Anthonappa, R P; King, N M

    2016-12-01

    To assess the reliability of the vertical tube shift technique (VTST) and horizontal tube shift technique (HTST) for the localisation of unerupted supernumerary teeth (ST) in the anterior region of the maxilla. A convenience sample of 83 patients who attended a major teaching hospital because of unerupted ST was selected. Only non-syndromic patients with ST and who had complete clinical and radiographic and surgical records were included in the study. Ten examiners independently rated the paired set of radiographs for each technique. Chi-square test, paired t test and kappa statistics were employed to assess the intra- and inter-examiner reliability. Paired sets of 1660 radiographs (830 pairs for each technique) were available for the analysis. The overall sensitivity for VTST and HTST was 80.6 and 72.1% respectively, with slight inter-examiner and good intra-examiner reliability. Statistically significant differences were evident between the two localisation techniques (p < 0.05). Localisation of unerupted ST using VTST was more successful than HTST in the anterior region of the maxilla.

  7. Localisation of local nonlinearities in structural dynamics using spatially incomplete measured data

    Science.gov (United States)

    Wang, Xing; Khodaparast, Hamed Haddad; Shaw, Alexander D.; Friswell, Michael I.; Zheng, Gangtie

    2018-01-01

    This paper presents a procedure to localise nonlinear elements using spatially incomplete measured frequency response data from the structural vibration test. The method does not require measurements of all the responses associated with nonlinear elements and the information about the types of nonlinear elements. In this procedure, the Craig-Bampton reduction method is employed to reduce the dynamic equation onto the measured region and to project the nonlinear forces onto the measured degrees of freedom (DOFs), which are then called reduced nonlinear forces (RNFs). It is shown that the reduced nonlinear forces are the sum of the measured nonlinear forces and the projections of the unmeasured nonlinear forces through the transpose of linear constraint modes. Therefore, by analysing and comparing the magnitude of the reduced nonlinear forces obtained from experiments with the linear constraint modes, we can localise the nonlinear elements without directly measuring their responses. Numerical simulations of a discrete system with two nonlinearities and experimental data from a clamped beam with a nonlinear connection are used to validate the localisation procedure.

  8. Nonlinear elastic multi-path reciprocal method for damage localisation in composite materials.

    Science.gov (United States)

    Boccardi, S; Callá, D B; Ciampa, F; Meo, M

    2018-01-01

    Nonlinear ultrasonic techniques rely on the measurement of nonlinear elastic effects caused by the interaction of ultrasonic waves with the material damage, and have shown high sensitivity to detect micro-cracks and defects in the early stages. This paper presents a nonlinear ultrasonic technique, here named nonlinear elastic multi-path reciprocal method, for the identification and localisation of micro-damage in composite laminates. In the proposed methodology, a sparse array of surface bonded ultrasonic transducers is used to measure the second harmonic elastic response associated with the material flaw. A reciprocal relationship of nonlinear elastic parameters evaluated from multiple transmitter-receiver pairs is then applied to locate the micro-damage. Experimental results on a damaged composite panel revealed that an accurate damage localisation was obtained using the normalised second order nonlinear parameter with a high signal-to-noise-ratio (∼11.2dB), whilst the use of bicoherence coefficient provided high localisation accuracy with a lower signal-to-noise-ratio (∼1.8dB). The maximum error between the calculated and the real damage location was nearly 13mm. Unlike traditional linear ultrasonic techniques, the proposed nonlinear elastic multi-path reciprocal method allows detecting material damage on composite materials without a priori knowledge of the ultrasonic wave velocity nor a baseline with the undamaged component. Copyright © 2017. Published by Elsevier B.V.

  9. Effects of Energy Deposition Characteristics on Localised Forced Ignition of Homogeneous Mixtures

    Directory of Open Access Journals (Sweden)

    Dipal Patel

    2015-06-01

    Full Text Available The effects of the characteristic width of the energy deposition profile and the duration of energy deposition by the ignitor on localised forced ignition of stoichiometric and fuel-lean homogeneous mixtures have been analysed using simplified chemistry three-dimensional compressible Direct Numerical Simulation (DNS for different values of root-mean-square turbulent velocity fluctuation. The localised forced ignition is modelled using a source term in the energy transport equation, which deposits energy in a Gaussian manner from the centre of the ignitor over a stipulated period of time. It has been shown that the width of ignition energy deposition and the duration over which ignition energy is deposited have significant influences on the success of ignition and subsequent flame propagation. An increase in the width of ignition energy deposition (duration of energy deposition for a given amount of ignition energy has been found to have a detrimental effect on the ignition event, which may ultimately lead to misfire. Moreover, an increase in u′ gives rise to augmented heat transfer rate from the hot gas kernel, which in turn leads to a reduction in the extent of overall burning for both stoichiometric and fuel-lean homogeneous mixtures but the detrimental effects of high values of u′ on localised ignition are particularly prevalent for fuel-lean mixtures.

  10. Counterintuitive electron localisation from density-functional theory with polarisable solvent models

    Energy Technology Data Exchange (ETDEWEB)

    Dale, Stephen G., E-mail: sdale@ucmerced.edu [Chemistry and Chemical Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Road, Merced, California 95343 (United States); Johnson, Erin R., E-mail: erin.johnson@dal.ca [Department of Chemistry, Dalhousie University, 6274 Coburg Road, Halifax, Nova Scotia B3H 4R2 (Canada)

    2015-11-14

    Exploration of the solvated electron phenomena using density-functional theory (DFT) generally results in prediction of a localised electron within an induced solvent cavity. However, it is well known that DFT favours highly delocalised charges, rendering the localisation of a solvated electron unexpected. We explore the origins of this counterintuitive behaviour using a model Kevan-structure system. When a polarisable-continuum solvent model is included, it forces electron localisation by introducing a strong energetic bias that favours integer charges. This results in the formation of a large energetic barrier for charge-hopping and can cause the self-consistent field to become trapped in local minima thus converging to stable solutions that are higher in energy than the ground electronic state. Finally, since the bias towards integer charges is caused by the polarisable continuum, these findings will also apply to other classical polarisation corrections, as in combined quantum mechanics and molecular mechanics (QM/MM) methods. The implications for systems beyond the solvated electron, including cationic DNA bases, are discussed.

  11. Localisation of antinutrients and qualitative identification of toxic components in Jatropha curcas seed.

    Science.gov (United States)

    Devappa, Rakshit K; Makkar, Harinder P S; Becker, Klaus

    2012-05-01

    Jatropha curcas seed oil is a promising feedstock for biodiesel production. The seeds contain major toxic (phorbol esters, PEs) and antinutritional (phytate and trypsin inhibitor) factors. In the present study the localisation of antinutrients and a rapid qualitative method for detecting the presence of PEs were investigated. Kernels were separated into cotyledon, hypocotyl, kernel coat and endosperm. The majority of phytate (96.5%), trypsin inhibitor (95.3%) and PEs (85.7%) were localised in the endosperm. Based on PEs, a qualitative method was developed to differentiate between toxic and non-toxic Jatropha genotypes. In this method, PEs were easily detected by passing methanol extracts of kernels (Jatropha toxic and non-toxic genotypes) through a solid phase extraction (SPE) column and measuring the absorption of the resulting eluates at 280 nm. For raw kernels, SPE eluates with absorbance ≥ 0.056 were considered as toxic and those with absorbance ≤0.032 as non-toxic. For defatted kernel meals, SPE eluates with absorbance ≥ 0.059 were considered as toxic and those with absorbance ≤0.043 as non-toxic. The majority of antinutrients/toxic compounds are localised in the endosperm of the kernel. The qualitative method developed for rapid identification of toxic PEs could be useful in screening the toxicity of Jatropha-based products in the biodiesel industry. Further confirmation of PEs should be established by high-performance liquid chromatography. Copyright © 2011 Society of Chemical Industry.

  12. Immunocytochemical localisation of phospholipid hydroperoxide glutathione peroxidase in bull’s spermatogenic cells

    Directory of Open Access Journals (Sweden)

    Francesco Parillo

    2014-09-01

    Full Text Available Phospholipid hydroperoxide glutathione peroxidase (PHGPx is a selenoprotein, which protects biomembranes from oxidative damages, and it also accounts for almost the entire selenium content of mammalian testis. The present investigation was performed to localise PHGPx in the testis and in epididymal and ejaculated spermatozoa of the bull by using light and electron immunomicroscopy. The study also aimed to further clarify the possible functions of the protein in bull fertility. In the testis, spermatogenic cells of the adluminal tubular compartment showed cytoplasmatic immunostaining; whereas, in the epididymal and ejaculated spermatozoa immunostaining was specifically localised at the level of the head and mid-piece. Ultrastructural data revealed the presence of signals for PHGPx in different subcellular compartments of maturing and mature sperm (mitochondria, chromatin, nuclear envelope, acrosomes, cytoskeletal structures suggesting that this enzyme plays versatile and important biological roles during spermatogenesis. The final localisation of the immunostaining at acrosomal level puts forward a new role of the protein which further emphasises its relevance in male reproduction: it is reported to anchor substrate of the sperm acrosome to the oocyte zona pellucida during the fertilisation process.

  13. Localisation and substrate specificities of transglycanases in charophyte algae relate to development and morphology.

    Science.gov (United States)

    Herburger, Klaus; Ryan, Louise M; Popper, Zoë A; Holzinger, Andreas

    2017-08-21

    Cell wall-modifying enzymes were previously investigated in charophyte green algae (CGA) from cultures of uniform age, giving limited insight into their roles. Therefore, we investigated the in situ localisation and specificity of enzymes acting on hemicelluloses in CGA genera of different morphologies and developmental stages. In vivo transglycosylation between xyloglucan and an endogenous donor in filamentous Klebsormidium and Zygnema showed action in longitudinal cell walls of young (1 month) but not old cells (1 year), suggesting involvement in cell growth. Contrastingly, in parenchymatous Chara, transglycanase action occurred in all cell planes. In Klebsormidium and Zygnema, enzyme action predominately co-localised with xyloglucans and mannans, to a lesser extent mixed-linkage β-glucan (MLG), indicating predominantly xyloglucan:xyloglucan endotransglucosylase (XET). Novel transglycosylation activities between xyloglucan and xylan, and xyloglucan and galactomannan were identified in vitro, in both genera. Our results show that several cell wall-modifying enzymes are present in CGA and that differences in morphology and cell age are related to enzyme localisation and specificity. This indicates an evolutionary significance of cell wall modifications, as similar changes are known from their immediate descendants, the land plants. © 2017. Published by The Company of Biologists Ltd.

  14. An Autonomous Wearable System for Predicting and Detecting Localised Muscle Fatigue

    Directory of Open Access Journals (Sweden)

    Martin Colley

    2011-01-01

    Full Text Available Muscle fatigue is an established area of research and various types of muscle fatigue have been clinically investigated in order to fully understand the condition. This paper demonstrates a non-invasive technique used to automate the fatigue detection and prediction process. The system utilises the clinical aspects such as kinematics and surface electromyography (sEMG of an athlete during isometric contractions. Various signal analysis methods are used illustrating their applicability in real-time settings. This demonstrated system can be used in sports scenarios to promote muscle growth/performance or prevent injury. To date, research on localised muscle fatigue focuses on the clinical side and lacks the implementation for detecting/predicting localised muscle fatigue using an autonomous system. Results show that automating the process of localised muscle fatigue detection/prediction is promising. The autonomous fatigue system was tested on five individuals showing 90.37% accuracy on average of correct classification and an error of 4.35% in predicting the time to when fatigue will onset.

  15. Illumination-invariant image matching for autonomous UAV localisation based on optical sensing

    Science.gov (United States)

    Wan, Xue; Liu, Jianguo; Yan, Hongshi; Morgan, Gareth L. K.

    2016-09-01

    This paper presents an UAV (Unmanned Aerial Vehicle) localisation algorithm for its autonomous navigation based on matching between on-board UAV image sequences to a pre-installed reference satellite image. As the UAV images and the reference image are not necessarily taken under the same illumination condition, illumination-invariant image matching is essential. Based on the investigation of illumination-invariant property of Phase Correlation (PC) via mathematical derivation and experiments, we propose a PC based fast and robust illumination-invariant localisation algorithm for UAV navigation. The algorithm accurately determines the current UAV position as well as the next UAV position even the illumination condition of UAV on-board images is different from the reference satellite image. A Dirac delta function based registration quality assessment together with a risk alarming criterion is introduced to enable the UAV to perform self-correction in case the UAV deviates from the planned route. UAV navigation experiments using simulated terrain shading images and remote sensing images have demonstrated a robust high performance of the proposed PC based localisation algorithm under very different illumination conditions resulted from solar motion. The superiority of the algorithm, in comparison with two other widely used image matching algorithms, MI (Mutual Information) and NCC (Normalised Correlation Coefficient), is significant for its high matching accuracy and fast processing speed.

  16. Analysis of a realistic and idealized dispersion compensating photonic crystal fiber Raman Amplifier

    DEFF Research Database (Denmark)

    Varshney, S.K.; Saitoh, K.; Koshiba, M.

    2007-01-01

    In the present paper, the highly efficient Raman amplification properties of a realistic and idealized dispersion compensating photonic crystal fiber (DCPCF) are described numerically. We have used an accurate full-vectorial finite element modal solver with hybrid curvilinear edge/nodal elements...... and anisotropic perfectly matched layers for an accurate modal characterization of the realistic as well as idealized DCPCF. A good agreement is observed between numerically evaluated and experimentally [P.J. Roberts, B.J. Mangan, H. Sabert, F. Couny, et al., J. Opt. Fiber Commun. Rep. 2 (2005) 435-461] measured...... dispersion values. A high peak Raman gain efficiency of 10.5 W-¹?km-¹ is obtained at 13.1 THz frequency shift for a 1455 nm depolarized pump. A DCPCF module of 1-km length can compensate for the dispersion accumulated over 70-km of conventional single mode fiber link with a residual dispersion of +/-50 ps...

  17. Statistical Theory of the Ideal MHD Geodynamo

    Science.gov (United States)

    Shebalin, J. V.

    2012-01-01

    A statistical theory of geodynamo action is developed, using a mathematical model of the geodynamo as a rotating outer core containing an ideal (i.e., no dissipation), incompressible, turbulent, convecting magnetofluid. On the concentric inner and outer spherical bounding surfaces the normal components of the velocity, magnetic field, vorticity and electric current are zero, as is the temperature fluctuation. This allows the use of a set of Galerkin expansion functions that are common to both velocity and magnetic field, as well as vorticity, current and the temperature fluctuation. The resulting dynamical system, based on the Boussinesq form of the magnetohydrodynamic (MHD) equations, represents MHD turbulence in a spherical domain. These basic equations (minus the temperature equation) and boundary conditions have been used previously in numerical simulations of forced, decaying MHD turbulence inside a sphere [1,2]. Here, the ideal case is studied through statistical analysis and leads to a prediction that an ideal coherent structure will be found in the form of a large-scale quasistationary magnetic field that results from broken ergodicity, an effect that has been previously studied both analytically and numerically for homogeneous MHD turbulence [3,4]. The axial dipole component becomes prominent when there is a relatively large magnetic helicity (proportional to the global correlation of magnetic vector potential and magnetic field) and a stationary, nonzero cross helicity (proportional to the global correlation of velocity and magnetic field). The expected angle of the dipole moment vector with respect to the rotation axis is found to decrease to a minimum as the average cross helicity increases for a fixed value of magnetic helicity and then to increase again when average cross helicity approaches its maximum possible value. Only a relatively small value of cross helicity is needed to produce a dipole moment vector that is aligned at approx.10deg with the

  18. Dimensional analysis using toric ideals: primitive invariants.

    Directory of Open Access Journals (Sweden)

    Mark A Atherton

    Full Text Available Classical dimensional analysis in its original form starts by expressing the units for derived quantities, such as force, in terms of power products of basic units [Formula: see text] etc. This suggests the use of toric ideal theory from algebraic geometry. Within this the Graver basis provides a unique primitive basis in a well-defined sense, which typically has more terms than the standard Buckingham approach. Some textbook examples are revisited and the full set of primitive invariants found. First, a worked example based on convection is introduced to recall the Buckingham method, but using computer algebra to obtain an integer [Formula: see text] matrix from the initial integer [Formula: see text] matrix holding the exponents for the derived quantities. The [Formula: see text] matrix defines the dimensionless variables. But, rather than this integer linear algebra approach it is shown how, by staying with the power product representation, the full set of invariants (dimensionless groups is obtained directly from the toric ideal defined by [Formula: see text]. One candidate for the set of invariants is a simple basis of the toric ideal. This, although larger than the rank of [Formula: see text], is typically not unique. However, the alternative Graver basis is unique and defines a maximal set of invariants, which are primitive in a simple sense. In addition to the running example four examples are taken from: a windmill, convection, electrodynamics and the hydrogen atom. The method reveals some named invariants. A selection of computer algebra packages is used to show the considerable ease with which both a simple basis and a Graver basis can be found.

  19. Development of a prototype of the tele-localisation system in radiotherapy using personal digital assistant via wireless communication.

    Science.gov (United States)

    Wu, Vincent Wing-Cheung; Tang, Fuk-hay; Cheung, Wai-kwan; Chan, Kit-chi

    2013-02-01

    In localisation of radiotherapy treatment field, the oncologist is present at the simulator to approve treatment details produced by the therapist. Problems may arise if the oncologist is not available and the patient requires urgent treatment. The development of a tele-localisation system is a potential solution, where the oncologist uses a personal digital assistant (PDA) to localise the treatment field on the image sent from the simulator through wireless communication and returns the information to the therapist after his or her approval. Our team developed the first tele-localisation prototype, which consisted of a server workstation (simulator) for the administration of digital imaging and communication in medicine localisation images including viewing and communication with the PDA via a Wi-Fi network; a PDA (oncologist's site) installed with the custom-built programme that synchronises with the server workstation and performs treatment field editing. Trial tests on accuracy and speed of the prototype system were conducted on 30 subjects with the treatment regions covering the neck, skull, chest and pelvis. The average time required in performing the localisation using the PDA was less than 1.5 min, with the blocked field longer than the open field. The transmission speed of the four treatment regions was similar. The average physical distortion of the images was within 4.4% and the accuracy of field size indication was within 5.3%. Compared with the manual method, the tele-localisation system presented with an average deviation of 5.5%. The prototype system fulfilled the planned objectives of tele-localisation procedure with reasonable speed and accuracy. © 2012 The Authors. Journal of Medical Imaging and Radiation Oncology © 2012 The Royal Australian and New Zealand College of Radiologists.

  20. Generalized Ideal Gas Equations for Structureful Universe

    Directory of Open Access Journals (Sweden)

    Khalid Khan

    2006-09-01

    Full Text Available We have derived generalized ideal gas equations for a structureful universe consistingof all forms of matters. We have assumed a universe that contains superclusters. Superclusters arethen made of clusters. Each cluster can be further divided into smaller ones and so on. We havederived an expression for the entropy of such a universe. Our model is rather independent of thegeometry of the intermediate clusters. Our calculations are valid for a non-interacting universewithin non-relativistic limits. We suggest that structure formation can reduce the expansion rateof the universe.

  1. Kant y el ideal del sabio

    Directory of Open Access Journals (Sweden)

    Eduardo Molina

    2013-01-01

    Full Text Available En este artículo se analiza la posible influencia del estoicismo en algunos aspectos precisos de la ética kantiana. Se intenta defender la tesis de que, aunque Kant critica muchas veces la ética estoica y en especial su eudemonismo, también adopta en su ética algunas de las posiciones estoicas y las incorpora en ciertos aspectos clave de su propia Doctrina de la virtud. En especial, se intenta mostrar cómo adopta Kant el ideal del sabio estoico y una de sus características más notables: la apatía.

  2. Hamiltonian description of the ideal fluid

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, P.J.

    1994-01-01

    Fluid mechanics is examined from a Hamiltonian perspective. The Hamiltonian point of view provides a unifying framework; by understanding the Hamiltonian perspective, one knows in advance (within bounds) what answers to expect and what kinds of procedures can be performed. The material is organized into five lectures, on the following topics: rudiments of few-degree-of-freedom Hamiltonian systems illustrated by passive advection in two-dimensional fluids; functional differentiation, two action principles of mechanics, and the action principle and canonical Hamiltonian description of the ideal fluid; noncanonical Hamiltonian dynamics with examples; tutorial on Lie groups and algebras, reduction-realization, and Clebsch variables; and stability and Hamiltonian systems.

  3. Eigenvalue statistics in quantum ideal gases

    CERN Document Server

    Eckhardt, B

    1998-01-01

    The eigenvalue statistics of quantum ideal gases with single particle energies $e_n=n^\\alpha$ are studied. A recursion relation for the partition function allows to calculate the mean density of states from the asymptotic expansion for the single particle density. For integer $\\alpha>1$ one expects and finds number theoretic degeneracies and deviations from the Poissonian spacing distribution. By semiclassical arguments, the length spectrum of the classical system is shown to be related to sums of integers to the power related to sums of cubes, for which one again expects number theoretic degeneracies, with consequences for the two point correlation function.

  4. Extra-Training I-deals

    DEFF Research Database (Denmark)

    Elgoibar, Patricia; Lindholst, Morten

    2016-01-01

    agreements of a nonstandard nature that individual employees negotiate with their employer regarding terms which benefit each party (Rousseau, 2000). The key question is to find the way in which these agreements are beneficial to the company, the manager, the employee and the co-workers. This case...... illustrates the negotiation process between a team manager at TNK - a leading multinational software development company- and one of his team members. The employee is willing to negotiate an I-deal with the objective of attending a training course abroad. This case is a two-party employment deal...

  5. Magnetic stresses in ideal MHD plasmas

    DEFF Research Database (Denmark)

    Jensen, V.O.

    1995-01-01

    The concept of magnetic stresses in ideal MHD plasma theory is reviewed and revisited with the aim of demonstrating its advantages as a basis for calculating and understanding plasma equilibria. Expressions are derived for the various stresses that transmit forces in a magnetized plasma...... and it is shown that the resulting magnetic forces on a finite volume element can be obtained by integrating the magnetic stresses over the surface of the element. The concept is used to rederive and discuss the equilibrium conditions for axisymmetric toroidal plasmas, including the virial theorem...

  6. Patterning monolayer graphene with zigzag edges on hexagonal boron nitride by anisotropic etching

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guole; Wu, Shuang; Zhang, Tingting; Chen, Peng; Lu, Xiaobo; Wang, Shuopei; Wang, Duoming; Shi, Dongxia; Yang, Rong, E-mail: ryang@iphy.ac.cn, E-mail: gyzhang@iphy.ac.cn [Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Watanabe, Kenji; Taniguchi, Takashi [National Institute for Materials Science, 1-1 Namiki, Tsukuba 305-0044 (Japan); Zhang, Guangyu, E-mail: ryang@iphy.ac.cn, E-mail: gyzhang@iphy.ac.cn [Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190 (China); Collaborative Innovation Center of Quantum Matter, Beijing 100190 (China); Beijing Key Laboratory for Nanomaterials and Nanodevices, Beijing 100190 (China)

    2016-08-01

    Graphene nanostructures are potential building blocks for nanoelectronic and spintronic devices. However, the production of monolayer graphene nanostructures with well-defined zigzag edges remains a challenge. In this paper, we report the patterning of monolayer graphene nanostructures with zigzag edges on hexagonal boron nitride (h-BN) substrates by an anisotropic etching technique. We found that hydrogen plasma etching of monolayer graphene on h-BN is highly anisotropic due to the inert and ultra-flat nature of the h-BN surface, resulting in zigzag edge formation. The as-fabricated zigzag-edged monolayer graphene nanoribbons (Z-GNRs) with widths below 30 nm show high carrier mobility and width-dependent energy gaps at liquid helium temperature. These high quality Z-GNRs are thus ideal structures for exploring their valleytronic or spintronic properties.

  7. Automaticity and localisation of concurrents predicts colour area activity in grapheme-colour synaesthesia.

    Science.gov (United States)

    Gould van Praag, Cassandra D; Garfinkel, Sarah; Ward, Jamie; Bor, Daniel; Seth, Anil K

    2016-07-29

    In grapheme-colour synaesthesia (GCS), the presentation of letters or numbers induces an additional 'concurrent' experience of colour. Early functional MRI (fMRI) investigations of GCS reported activation in colour-selective area V4 during the concurrent experience. However, others have failed to replicate this key finding. We reasoned that individual differences in synaesthetic phenomenology might explain this inconsistency in the literature. To test this hypothesis, we examined fMRI BOLD responses in a group of grapheme-colour synaesthetes (n=20) and matched controls (n=20) while characterising the individual phenomenology of the synaesthetes along dimensions of 'automaticity' and 'localisation'. We used an independent functional localiser to identify colour-selective areas in both groups. Activations in these areas were then assessed during achromatic synaesthesia-inducing, and non-inducing conditions; we also explored whole brain activations, where we sought to replicate the existing literature regarding synaesthesia effects. Controls showed no significant activations in the contrast of inducing > non-inducing synaesthetic stimuli, in colour-selective ROIs or at the whole brain level. In the synaesthete group, we correlated activation within colour-selective ROIs with individual differences in phenomenology using the Coloured Letters and Numbers (CLaN) questionnaire which measures, amongst other attributes, the subjective automaticity/attention in synaesthetic concurrents, and their spatial localisation. Supporting our hypothesis, we found significant correlations between individual measures of synaesthetic phenomenology and BOLD responses in colour-selective areas, when contrasting inducing against non-inducing stimuli. Specifically, left-hemisphere colour area responses were stronger for synaesthetes scoring high on phenomenological localisation and automaticity/attention, while right-hemisphere colour area responses showed a relationship with localisation

  8. Plasma response measurements of external magnetic perturbations using electron cyclotron emission and comparisons to 3D ideal MHD equilibrium

    CERN Document Server

    Willensdorfer, M; Strumberger, E; Suttrop, W; Vanovac, B; Brida, D; Cavedon, M; Classen, I; Dunne, M; Fietz, S; Fischer, R; Kirk, A; Laggner, F M; Liu, Y Q; Odstrcil, T; Ryan, D A; Viezzer, E; Zohm, H; Luhmann, I C

    2016-01-01

    The plasma response from an external n = 2 magnetic perturbation field in ASDEX Upgrade has been measured using mainly electron cyclotron emission (ECE) diagnostics and a rigid rotating field. To interpret ECE and ECE-imaging (ECE-I) measurements accurately, forward modeling of the radiation transport has been combined with ray tracing. The measured data is compared to synthetic ECE data generated from a 3D ideal magnetohydrodynamics (MHD) equilibrium calculated by VMEC. The measured amplitudes of the helical displacement in the midplane are in reasonable agreement with the one from the synthetic VMEC diagnostics. Both exceed the vacuum field calculations and indicate the presence of an amplified kink response at the edge. Although the calculated magnetic structure of this edge kink peaks at poloidal mode numbers larger than the resonant components |m| > |nq|, the displacement measured by ECE-I is almost resonant |m| ~ |nq|. This is expected from ideal MHD in the proximity of rational surfaces. VMEC and MARS-...

  9. Rough semigroups and rough fuzzy semigroups based on fuzzy ideals

    Directory of Open Access Journals (Sweden)

    Wang Qiumei

    2016-01-01

    Full Text Available In this paper, we firstly introduce a special congruence relation U(μ, t induced by a fuzzy ideal μ in a semigroup S. Then we define the lower and upper approximations based on a fuzzy ideal in semigroups. We can establish rough semigroups, rough ideals, rough prime ideals, rough fuzzy semigroups, rough fuzzy ideals and rough fuzzy prime ideals according to the definitions of rough sets and rough fuzzy sets. Furthermore, we shall consider the relationships among semigroups and rough semigroups, fuzzy semigroups and rough fuzzy semigroups, and some relative properties are also discussed.

  10. Conservative regularization of ideal hydrodynamics and magnetohydrodynamics

    Science.gov (United States)

    Thyagaraja, A.

    2010-03-01

    Inviscid, incompressible hydrodynamics and incompressible ideal magnetohydrodynamics (MHD) share many properties such as time-reversal invariance of equations, conservation laws, and certain topological features. In three dimensions, these systems may lead to singular solutions (involving vortex and current sheets). While dissipative (viscoresistive) effects can regularize the equations leading to bounded solutions to the initial-boundary value (Cauchy) problem which presumably exist uniquely, the time-reversal symmetry and associated conservation properties are certainly destroyed. The present work is analogous to (and suggested by) the Korteweg-de Vries regularization of the one-dimensional, nonlinear kinematic wave equation. Thus the regularizations applied to the original equations of hydrodynamics and ideal MHD retain conservation properties and the symmetries of the original equations. Integral invariants which generalize those known for the original systems are shown to imply bounded enstrophy. The regularization developed can also be applied to the corresponding dissipative models (such as the Navier-Stokes equations and the viscoresistive MHD equations) and may imply interesting regularity properties for the solutions of the latter as well. The models developed thus have intrinsic mathematical interest as well as possible applications to large-scale numerical simulations in systems where dissipative effects are extremely small or even absent.

  11. What constitutes an ideal dental restorative material?

    Science.gov (United States)

    Rekow, E D; Bayne, S C; Carvalho, R M; Steele, J G

    2013-11-01

    Intense environmental concerns recently have prompted dentistry to evaluate the performance and environmental impact of existing restoration materials. Doing so entices us to explore the 'what if?' innovation in materials science to create more ideal restorative materials. Articulating a specification for our design and evaluation methods is proving to be more complicated than originally anticipated. Challenges exist not only in specifying how the material should be manipulated and perform clinically but also in understanding and incorporating implications of the skill of the operator placing the restoration, economic considerations, expectations patients have for their investment, cost-effectiveness, influences of the health care system on how and for whom restorations are to be placed, and global challenges that limit the types of materials available in different areas of the world. The quandary is to find ways to actively engage multiple stakeholders to agree on priorities and future actions to focus future directions on the creation of more ideal restorative materials that can be available throughout the world.

  12. Ideal relaxation of the Hopf fibration

    Science.gov (United States)

    Smiet, Christopher Berg; Candelaresi, Simon; Bouwmeester, Dirk

    2017-07-01

    Ideal magnetohydrodynamics relaxation is the topology-conserving reconfiguration of a magnetic field into a lower energy state where the net force is zero. This is achieved by modeling the plasma as perfectly conducting viscous fluid. It is an important tool for investigating plasma equilibria and is often used to study the magnetic configurations in fusion devices and astrophysical plasmas. We study the equilibrium reached by a localized magnetic field through the topology conserving relaxation of a magnetic field based on the Hopf fibration in which magnetic field lines are closed circles that are all linked with one another. Magnetic fields with this topology have recently been shown to occur in non-ideal numerical simulations. Our results show that any localized field can only attain equilibrium if there is a finite external pressure, and that for such a field a Taylor state is unattainable. We find an equilibrium plasma configuration that is characterized by a lowered pressure in a toroidal region, with field lines lying on surfaces of constant pressure. Therefore, the field is in a Grad-Shafranov equilibrium. Localized helical magnetic fields are found when plasma is ejected from astrophysical bodies and subsequently relaxes against the background plasma, as well as on earth in plasmoids generated by, e.g., a Marshall gun. This work shows under which conditions an equilibrium can be reached and identifies a toroidal depression as the characteristic feature of such a configuration.

  13. An ideal sealed source life-cycle

    Energy Technology Data Exchange (ETDEWEB)

    Tompkins, Joseph Andrew [Los Alamos National Laboratory

    2009-01-01

    we have today. This regulation created a new regulatory framework seen as promising at the time. However, now they recognize that, despite the good intentions, the NIJWP/85 has not solved any source disposition problems. The answer to these sealed source disposition problems is to adopt a philosophy to correct these regulatory issues, determine an interim solution, execute that solution until there is a minimal backlog of sources to deal with, and then let the mechanisms they have created solve this problem into the foreseeable future. The primary philosophical tenet of the ideal sealed source life cycle follows. You do not allow the creation (or importation) of any source whose use cannot be justified, which cannot be affordably shipped, or that does not have a well-delinated and affordable disposition pathway. The path forward dictates that we fix the problem by embracing the Ideal Source Life cycle. In figure 1, we can see some of the elements of the ideal source life cycle. The life cycle is broken down into four portions, manufacture, use, consolidation, and disposition. These four arbitrary elements allow them to focus on the ideal life cycle phases that every source should go through between manufacture and final disposition. As we examine the various phases of the sealed source life cycle, they pick specific examples and explore the adoption of the ideal life cycle model.

  14. The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading

    OpenAIRE

    Copsey, Alice C.; Cooper, Simon; Parker, Robert; Lineham, Ella; Lapworth, Cuzack; JALLAD, Deema Basil Sadiq; Sweet, Steve; Morley, Simon J.

    2017-01-01

    DDX3X, a helicase, can interact directly with mRNA and translation initiation factors, regulating the selective translation of mRNAs that contain a structured 5? untranslated region. This activity modulates the expression of mRNAs controlling cell cycle progression and mRNAs regulating actin dynamics, contributing to cell adhesion and motility. Previously, we have shown that ribosomes and translation initiation factors localise to the leading edge of migrating fibroblasts in loci enriched wit...

  15. On demand: The singular rht net, an ideal blueprint for the construction of a metal-organic framework (mof) platform

    KAUST Repository

    Eubank, Jarrod F.

    2012-09-07

    The exceptional nature of the rht-MOF platform, based on a singular edge-transitive net (the only net for the combination of 3- and 24-connected nodes), makes it an ideal target in crystal chemistry. The high level of control indicates an unparalleled blueprint for isoreticular functional materials (without concern for interpenetration) for targeted applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. The unintended influence of control systems on edge-plasma transport and stability in the Joint European Torus

    CERN Document Server

    Webster, A J; Todd, T N; Brezinsek, S; Contributors, JET EFDA

    2014-01-01

    A unique experiment in the Joint European Torus (JET) consecutively produced 120 almost identical plasma pulses, providing two orders of magnitude more data than is usually available. This allows the statistical detection of previously unobservable phenomena such as a sequence of resonant-like waiting times between edge-localised instabilities (ELMs). Here we investigate the causes of this phenomenon. By synchronising data to the 1000s of ELM times and averaging the results, random errors are reduced by a factor of 50, allowing unprecedentedly detailed behaviour to be described. A clear link can then be observed between plasma confinement, ELM occurrence, vertical plasma oscillations, and an otherwise unobservable oscillation in a control coil current that is not usually associated with ELM occurrence. The results suggest a strong and unanticipated edge-plasma dependence on control system behaviour.

  17. Edge imaging in intense beams

    Directory of Open Access Journals (Sweden)

    S. Bernal

    2002-06-01

    Full Text Available The appearance of rings of charge observed near the edge of beams from high-perveance guns is described with a simple ray tracing technique inspired by the particle-core model. We illustrate the technique, which has no analog in light optics, with examples from experiments employing solenoid focusing of an electron beam. The rings of charge result from the combined effects of external focusing and space-charge forces acting on paraxial fringe particles with relatively large initial transverse velocities. The model is independent of the physical mechanisms responsible for the fringe particles. Furthermore, the focal length for edge imaging in a uniform focusing channel is derived using a linearized trajectory equation for the motion of fringe particles. Counterintuitively, the focal length decreases as the beam current increases.

  18. Scattering by an axisymmetric edge

    Science.gov (United States)

    Kaloshin, V. A.; Popov, A. P.

    1984-08-01

    A method of physical theory of diffraction (PTD) in an axisymmetric problem is used to obtain the first two terms of the uniform asymptotics of the radiation pattern of an edge wave with respect to inverse semiinteger powers of the wavenumber expressed through a two-term uniform asymptotics of the corresponding two-dimensional problem. As examples, calculations are made of: (1) the uniform asymptotics of the correction refining the Kirchhoff approximation for the radiation pattern of an axisymmetric reflector antenna; and (2) the asymptotics of the radiation pattern of symmetric modes from the open end of a circular flanged waveguide. An improvement of the PTD method is proposed for calculating the second term of the uniform asymptotics of an edge wave with respect to inverse powers of the wavenumber; the example of the diffraction of a toroidal wave by a bicone is considered.

  19. Edge Simulation Laboratory Project Report

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, R. H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dorf, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Dorr, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Rognlien, T. D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-02-25

    In 2010 The Edge Simulation Laboratory (ESL) embarked upon the plan laid out in the renewal proposal submitted in December 2009. This proposal called for initially parallel efforts addressing the physics of the closed-flux-surface pedestal region, using existing computational tools (GYRO, BOUT++) and analytic modeling, and physics of the scrape-off layer via development of the new edge gyrokinetic code COGENT. Progress in the former area is described in a series of monthly progress reports prepared by General Atomics; these are attached as a set of appendices (describing work done in the month prior to the indicated date). Progress in the latter area, as well as associated theoretical development, is described.

  20. Degradation of (moral values in the context of the ego ideal and the ideal ego

    Directory of Open Access Journals (Sweden)

    Todorović Milorad V.

    2016-01-01

    Full Text Available All conclusions about some psychological characteristics or content must derive from relations of social, or better yet, epochal changes and structure they create. General agreement - admittedly biased and without access to a constant fact which is not close to any transitional movements - that the times are unstable - does not end with a precise understanding of how much would that instability reflect on the formation of a stable character. It could be said that this particular level of structuration, which connects 'the external' and 'the internal', is consistently absent in most theories. This especially applies to our central self, our consciousness, the authoritative part of us that sets standards and has been wrongly equated with universal truths, general principles and something that is considered to be common to all people. All complexity of formation of the super­ego, as the lastly formed instance that is also responsible for the sense of duty or the sense of moral obligation, has always been a result of the current form of structuration and has always been realized, more or less, as a distorted memory of certain, quite determined, events that a subject was overwhelmed with. If we listen to our own tendencies toward instability, we will not fall into the trap which is often present when describing ourselves, i.e. the belief that we have 'a real self', common to all human beings, whose requests are more important than requests of all others. However, outside of dynamic psychology, it would be difficult to understand how Lacan's 'split entity' could ever have 'a real self' whose requests are, especially concerning morality, more important than all other requests. Human nature has most easily been introduced into the norm by those ideals that had insisted on denial, and are located in the ego ideal. When 'ideals' moved, usually behind a screen of freedom and urge for individualization, the pleasure returned to nature in the form of ego

  1. The Slice Algorithm For Irreducible Decomposition of Monomial Ideals

    DEFF Research Database (Denmark)

    Roune, Bjarke Hammersholt

    2009-01-01

    Irreducible decomposition of monomial ideals has an increasing number of applications from biology to pure math. This paper presents the Slice Algorithm for computing irreducible decompositions, Alexander duals and socles of monomial ideals. The paper includes experiments showing good performance...

  2. Environmental Dataset Gateway (EDG) REST Interface

    Data.gov (United States)

    U.S. Environmental Protection Agency — Use the Environmental Dataset Gateway (EDG) to find and access EPA's environmental resources. Many options are available for easily reusing EDG content in other...

  3. Symmetry transforms for ideal magnetohydrodynamics equilibria.

    Science.gov (United States)

    Bogoyavlenskij, Oleg I

    2002-11-01

    A method for constructing ideal magnetohydrodynamics (MHD) equilibria is introduced. The method consists of the application of symmetry transforms to any known MHD equilibrium [ O. I. Bogoyavlenskij, Phys. Rev. E. 62, 8616, (2000)]. The transforms break the geometrical symmetries of the field-aligned solutions and produce continuous families of the nonsymmetric MHD equilibria. The method of symmetry transforms also allows to obtain MHD equilibria with current sheets and exact solutions with noncollinear vector fields B and V. A model of the nonsymmetric astrophysical jets outside of their accretion disks is developed. The total magnetic and kinetic energy of the jet is finite in any layer c(1)ball lightning with dynamics of plasma inside the fireball.

  4. Neem (Azadirachta indica): towards the ideal insecticide?

    Science.gov (United States)

    Benelli, Giovanni; Canale, Angelo; Toniolo, Chiara; Higuchi, Akon; Murugan, Kadarkarai; Pavela, Roman; Nicoletti, Marcello

    2017-02-01

    Pesticide resistance is going to change rapidly our antibiotics and insecticides arsenal. In this scenario, plant-derived natural products are considered valuable candidates to reverse this negative trend. Growing research attention is focused on neem (Azadirachta indica, Meliaceae), exploring the utility of its products as insecticides and antibiotics. In this review, we summarised the knowledge on neem oil and neem cake by-products in arthropod pest control, with special reference to mosquito vectors of public health importance. To the best of our knowledge, neem-borne products currently showed effective and eco-friendly features, including little non-target effects, multiple mechanisms of action, low cost, easy production in countries with limited industrial facilities. In particular, the potentiality of neem cake as ideal and affordable source of mosquitocidal compounds in anopheline and aedine control programmes is outlined. Overall, we propose the employ of neem-based products as an advantageous alternative to build newer and safer arthropod control tools.

  5. Activation of MHD reconnection on ideal timescales

    CERN Document Server

    Landi, S; Del Zanna, L; Tenerani, A; Pucci, F

    2016-01-01

    Magnetic reconnection in laboratory, space and astrophysical plasmas is often invoked to explain explosive energy release and particle acceleration. However, the timescales involved in classical models within the macroscopic MHD regime are far too slow to match the observations. Here we revisit the tearing instability by performing visco-resistive two-dimensional numerical simulations of the evolution of thin current sheets, for a variety of initial configurations and of values of the Lunquist number $S$, up to $10^7$. Results confirm that when the critical aspect ratio of $S^{1/3}$ is reached in the reconnecting current sheets, the instability proceeds on ideal (Alfv\\'enic) macroscopic timescales, as required to explain observations. Moreover, the same scaling is seen to apply also to the local, secondary reconnection events triggered during the nonlinear phase of the tearing instability, thus accelerating the cascading process to increasingly smaller spatial and temporal scales. The process appears to be ro...

  6. Active Microwave Metamaterials Incorporating Ideal Gain Devices

    Directory of Open Access Journals (Sweden)

    Hao Xin

    2010-12-01

    Full Text Available Incorporation of active devices/media such as transistors for microwave and gain media for optics may be very attractive for enabling desired low loss and broadband metamaterials. Such metamaterials can even have gain which may very well lead to new and exciting physical phenomena. We investigate microwave composite right/left-handed transmission lines (CRLH-TL incorporating ideal gain devices such as constant negative resistance. With realistic lumped element values, we have shown that the negative phase constant of this kind of transmission lines is maintained (i.e., left-handedness kept while gain can be obtained (negative attenuation constant of transmission line simultaneously. Possible implementation and challenging issues of the proposed active CRLH-TL are also discussed.

  7. Review of Idealized Aircraft Wake Vortex Models

    Science.gov (United States)

    Ahmad, Nashat N.; Proctor, Fred H.; Duparcmeur, Fanny M. Limon; Jacob, Don

    2014-01-01

    Properties of three aircraft wake vortex models, Lamb-Oseen, Burnham-Hallock, and Proctor are reviewed. These idealized models are often used to initialize the aircraft wake vortex pair in large eddy simulations and in wake encounter hazard models, as well as to define matched filters for processing lidar observations of aircraft wake vortices. Basic parameters for each vortex model, such as peak tangential velocity and circulation strength as a function of vortex core radius size, are examined. The models are also compared using different vortex characterizations, such as the vorticity magnitude. Results of Euler and large eddy simulations are presented. The application of vortex models in the postprocessing of lidar observations is discussed.

  8. Tv nyheder: Journalistiske Idealer er under Pres

    DEFF Research Database (Denmark)

    Thomsen, Line Hassall

    2013-01-01

    flittigt. For når der bliver lavet en nyhed som seerne taler om, så vil den også få flere seere – få et ’like’ på Facebook og blive delt på Twitter. Journalisten der har lavet en nyhed der får mange likes bliver måske nævnt i en skulderklappende fællesmail fra nyhedsredaktøren, måske vinder han en flaske...... det helt naturligt at tv-cheferne tænker økonomi. Men at organisere hele nyhedsproduktionen omkring forbrug, priser, clicks, likes og markedslogik kan godt gå hen og være det værste der er sket for public service tv nyhederne. For lige netop journalisternes idealer om God Journalistik er måske det...

  9. Nonlinear current sheet formation in ideal plasmas

    Science.gov (United States)

    Voge, A.; Schindler, K.; Otto, A.

    1994-01-01

    We present a numerical study of the formation of current sheets in ideal plasmas. First we confirm the development of singular current sheets in a one-dimensional model. In a second step we extend the analysis to two-dimensional equilibria. Here it is found that the resulting structures are quiet insensitive to the boundary conditions. For the special case of a magnetotail like equilibrium it will be shown that the resulting current distribution provides a possibility to understand the onset of a localized anomalous resistivity from a macroscopic point of view. Furthermore, the resulting structures provide an explanation for the dramatic decrease of the thickness of the current sheet in the magnetotail prior to the onset of geomagnetic substorms.

  10. Broken Ergodicity in Ideal, Homogeneous, Incompressible Turbulence

    Science.gov (United States)

    Morin, Lee; Shebalin, John; Fu, Terry; Nguyen, Phu; Shum, Victor

    2010-01-01

    We discuss the statistical mechanics of numerical models of ideal homogeneous, incompressible turbulence and their relevance for dissipative fluids and magnetofluids. These numerical models are based on Fourier series and the relevant statistical theory predicts that Fourier coefficients of fluid velocity and magnetic fields (if present) are zero-mean random variables. However, numerical simulations clearly show that certain coefficients have a non-zero mean value that can be very large compared to the associated standard deviation. We explain this phenomena in terms of broken ergodicity', which is defined to occur when dynamical behavior does not match ensemble predictions on very long time-scales. We review the theoretical basis of broken ergodicity, apply it to 2-D and 3-D fluid and magnetohydrodynamic simulations of homogeneous turbulence, and show new results from simulations using GPU (graphical processing unit) computers.

  11. Ideal Technology Concept & its Realization Opportunity using Nanotechnology

    OpenAIRE

    Aithal, Sreeramana; Aithal, Shubhrajyotsna

    2015-01-01

    Technology has affected society and its surroundings in a number of ways. In many societies, technology has helped to develop more advanced economies (including today's global economy) and has supported the rise of a leisure class people. The concept of ideal engine, ideal switch, ideal semiconductor devices like ideal diodes, transistors, etc. have been defined and taken as standards to improve the quality and performance of such practical devices or systems. It is found t...

  12. (2n − 1)-Ideal amenability of triangular banach algebras

    Indian Academy of Sciences (India)

    They defined that Banach algebra A is ideally amenable if H1(A,I∗) = {0} for every closed (two-sided) ideal I in A. Gordji and. Memarbashi [7], authors studied the n-ideal amenability of Banach algebras such that A is n-ideally amenable if H1(A,I(n)) = {0}. Let A and B be two Banach algebras and M be an essential Banach A, ...

  13. Medical and Nursing Students: Concepts of Self and Ideal Self, Typical and Ideal Work Partner

    Science.gov (United States)

    Rein, Ingrid

    1977-01-01

    Dominance and sociability scores on the Interpersonal Check List were obtained for medical and nursing students. Results indicate a discrepancy between concepts of self and ideal self, as well as considerable disagreement between medical and nursing students about their roles on the physician-nurse team. (EVH)

  14. The direct effect of thin ideal focused adult television on young girls' ideal body figure

    NARCIS (Netherlands)

    Anschutz, D.J.; Spruijt-Metz, D.; Strien, T. van; Engels, R.C.M.E.

    2011-01-01

    The present study tested the direct effect of watching thin ideal focused television aimed at (young) adults on body dissatisfaction in preadolescent girls (9-12 years old). A within-subject design was used in which the girls (N=60) were tested three times. They watched three movie clips in random

  15. The direct effect of thin ideal focused adult television on young girls' ideal body figure

    NARCIS (Netherlands)

    Anschutz, D.J.; Spruijt-Metz, D.; van Strien, T.; Engels, R.C.M.E.

    2011-01-01

    The present study tested the direct effect of watching thin-ideal focused television aimed at (young) adults on body dissatisfaction in preadolescent girls (9-12 years old). A within-subject design was used in which the girls (N=60) were tested three times. They watched three movie clips in random

  16. The direct effect of thin ideal focused adult television on young girls' ideal body figure

    NARCIS (Netherlands)

    Anschutz, Doeschka J; Spruijt-Metz, Donna; van Strien, Tatjana; Engels, Rutger C M E

    The present study tested the direct effect of watching thin-ideal focused television aimed at (young) adults on body dissatisfaction in preadolescent girls (9-12 years old). A within-subject design was used in which the girls (N=60) were tested three times. They watched three movie clips in random

  17. Analytic stability criteria for edge MHD oscillations in high performance ELM free tokamak regimes

    Science.gov (United States)

    Brunetti, D.; Graves, J. P.; Lazzaro, E.; Mariani, A.; Nowak, S.; Cooper, W. A.; Wahlberg, C.

    2018-01-01

    A new dispersion relation, and associated stability criteria, is derived for low-n external kink and infernal modes, and is applied to modelling the stability properties of quiescent H-mode like regimes. The analysis, performed in toroidal geometry with large edge pressure gradients associated with a local flattening of the safety factor, includes a pedestal, sheared toroidal rotation and a vacuum region separating the plasma from an ideal metallic wall. The external kink-infernal modes found here exhibit similarities with experimentally observed edge harmonic oscillations.

  18. Mechanical failure of zigzag graphene nanoribbons under tensile strain induced by edge reconstruction

    KAUST Repository

    Cheng, Yingchun

    2012-10-01

    The structural and mechanical properties of graphene nanoribbons (GNRs) under uniaxial tensile strain are studied by density functional theory. The ideal strength of a zigzag GNR (120 GPa) is close to that of pristine graphene. However, for a GNR with both edges reconstructed to pentagon–heptagon pairs (from hexagon–hexagon pairs) it decreases to 94 GPa and the maximum tensile strain is reduced to 15%. Our results constitute a comprehensive picture of the edge structure effect on the mechanical properties of GNRs.

  19. Moral Identity as Moral Ideal Self: Links to Adolescent Outcomes

    Science.gov (United States)

    Hardy, Sam A.; Walker, Lawrence J.; Olsen, Joseph A.; Woodbury, Ryan D.; Hickman, Jacob R.

    2014-01-01

    The purposes of this study were to conceptualize moral identity as moral ideal self, to develop a measure of this construct, to test for age and gender differences, to examine links between moral ideal self and adolescent outcomes, and to assess purpose and social responsibility as mediators of the relations between moral ideal self and outcomes.…

  20. Ideal amenability of Banach algebras on locally compact groups

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    compact group G. We know that there exists a weakly amenable Banach algebra which is not ideally amenable, also every C∗. -algebra is ideally amenable [5]. We can not prove that for which locally compact group G, L1(G) is ideally amenable. Let A be a Banach algebra. The subspace X of A∗ is left introverted if X∗ · X ...

  1. Short Stickelberger class relations and application to Ideal-SVP

    NARCIS (Netherlands)

    R.J.F. Cramer (Ronald); L. Ducas (Léo); W. Wesolowski (Benjamin)

    2017-01-01

    textabstractThe worst-case hardness of finding short vectors in ideals of cyclotomic number fields (Ideal-SVP) is a central matter in lattice based cryptography. Assuming the worst-case hardness of Ideal- SVP allows to prove the Ring-LWE and Ring-SIS assumptions, and therefore to prove the security

  2. An Ideal Gas Law Simulator for Atmospheric Gas Molecules ...

    African Journals Online (AJOL)

    The ideal gas law which is the equation of state of a hypothetical ideal gas that allows us to gain useful insights into the behavior of most real gases at low densities was utilized in this work to conceptualize, design and develop the ideal gas law simulator in a 3 dimensional space using Microsoft Visual Studio, Microsoft ...

  3. Examples for Non-Ideal Solution Thermodynamics Study

    Science.gov (United States)

    David, Carl W.

    2004-01-01

    A mathematical model of a non-ideal solution is presented, where it is shown how and where the non-ideality manifests itself in the standard thermodynamics tableau. Examples related to the non-ideal solution thermodynamics study are also included.

  4. Characterization of Distributive and Standard Ideals in Semilattices

    African Journals Online (AJOL)

    Bheema

    introduced and studied by Hashimoto (1952); and Gratzer and Schmidt (1961). Properties of distributive ideals of Birkhoff (1967) are considered in our work. In this paper we studied the notion of distributive (dually) ideal and standard ideal in a semilattice of Gratzer (1978) and produced a characterization theorem of ...

  5. Black and White Adolescent Females Perceptions of Ideal Body Size.

    Science.gov (United States)

    Parnell, Kathy; And Others

    1996-01-01

    White and black adolescent females (n=344) participated in a survey of ideal body size beliefs using a questionnaire and 9 female and male body size drawings. Black females preferred a significantly heavier ideal female body size than whites and perceived that their parents and friends would select as ideal a significantly heavier female body size…

  6. Promoting Spiritual Ideals through Design Thinking in Public Schools

    Science.gov (United States)

    Tan, Charlene; Wong, Yew-Leong

    2012-01-01

    Against a backdrop of the debates on religious education in public or state schools, we argue for the introduction of "spiritual ideals" into the public school curriculum. We distinguish our notion of spiritual ideals from "religious ideals" as conceptualised by De Ruyter and Merry. While we agree with De Ruyter and Merry that…

  7. Evaluation of edge detectors using average risk

    NARCIS (Netherlands)

    Spreeuwers, Lieuwe Jan; van der Heijden, Ferdinand

    1992-01-01

    A new method for evaluation of edge detectors, based on the average risk of a decision, is discussed. The average risk is a performance measure well-known in Bayesian decision theory. Since edge detection can be regarded as a compound decision making process, the performance of an edge detector is

  8. Edge Transfer Lithography Using Alkanethiol Inks

    NARCIS (Netherlands)

    Sharpe, R.B.A.; Titulaer, Bram J.F.; Peeters, Emiel; Burdinski, Dirk; Huskens, Jurriaan; Zandvliet, Henricus J.W.; Reinhoudt, David; Poelsema, Bene

    2006-01-01

    Edge lithographic patterning techniques are based on the utilization of the edges of micrometer-sized template features for the reproduction of submicrometer structures. Edge transfer lithography (ETL) permits local surface modification in a single step by depositing self-assembled monolayers onto a

  9. Acyclicity in edge-colored graphs

    DEFF Research Database (Denmark)

    Gutin, Gregory; Jones, Mark; Sheng, Bin

    2017-01-01

    A walk W in edge-colored graphs is called properly colored (PC) if every pair of consecutive edges in W is of different color. We introduce and study five types of PC acyclicity in edge-colored graphs such that graphs of PC acyclicity of type i is a proper superset of graphs of acyclicity of type...

  10. From the ideal market to the ideal clinic: constructing a normative standard of fairness for human subjects research.

    Science.gov (United States)

    Phillips, Trisha

    2011-02-01

    Preventing exploitation in human subjects research requires a benchmark of fairness against which to judge the distribution of the benefits and burdens of a trial. This paper proposes the ideal market and its fair market price as a criterion of fairness. The ideal market approach is not new to discussions about exploitation, so this paper reviews Wertheimer's inchoate presentation of the ideal market as a principle of fairness, attempt of Emanuel and colleagues to apply the ideal market to human subjects research, and Ballantyne's criticisms of both the ideal market and the resulting benchmark of fairness. It argues that the criticism of this particular benchmark is on point, but the rejection of the ideal market is mistaken. After presenting a complete account of the ideal market, this paper proposes a new method for applying the ideal market to human subjects research and illustrates the proposal by considering a sample case.

  11. Hydroxysteroid dehydrogenase HSD1L is localised to the pituitary–gonadal axis of primates

    Directory of Open Access Journals (Sweden)

    A Daniel Bird

    2017-09-01

    Full Text Available Steroid hormones play clinically important and specific regulatory roles in the development, growth, metabolism, reproduction and brain function in human. The type 1 and 2 11-beta hydroxysteroid dehydrogenase enzymes (11β-HSD1 and 2 have key roles in the pre-receptor modification of glucocorticoids allowing aldosterone regulation of blood pressure, control of systemic fluid and electrolyte homeostasis and modulation of integrated metabolism and brain function. Although the activity and function of 11β-HSDs is thought to be understood, there exists an open reading frame for a distinct 11βHSD-like gene; HSD11B1L, which is present in human, non-human primate, sheep, pig and many other higher organisms, whereas an orthologue is absent in the genomes of mouse, rat and rabbit. We have now characterised this novel HSD11B1L gene as encoded by 9 exons and analysis of EST library transcripts indicated the use of two alternate ATG start sites in exons 2 and 3, and alternate splicing in exon 9. Relatively strong HSD11B1L gene expression was detected in human, non-human primate and sheep tissue samples from the brain, ovary and testis. Analysis in non-human primates and sheep by immunohistochemistry localised HSD11B1L protein to the cytoplasm of ovarian granulosa cells, testis Leydig cells, and gonadatroph cells in the anterior pituitary. Intracellular localisation analysis in transfected human HEK293 cells showed HSD1L protein within the endoplasmic reticulum and sequence analysis suggests that similar to 11βHSD1 it is membrane bound. The endogenous substrate of this third HSD enzyme remains elusive with localisation and expression data suggesting a reproductive hormone as a likely substrate.

  12. Audit of preoperative localisation of tumor with tattoo for patients undergoing laparoscopic colorectal surgery.

    Science.gov (United States)

    Saleh, A; Ihedioha, U; Babu, B; Evans, J; Kang, P

    2016-08-01

    Preoperative localisation of tumour is an essential requirement in laparoscopic colorectal surgery. Since the introduction of laparoscopic colorectal resections in NGH in February 2010, the difficulties of tumour localisation at the time of surgery without tattoo have been highlighted. Furthermore, endoscopic documentation of site of tattoo with respect to the tumour can be inconsistent and at times misleading or difficult to interpret. Tattooing guidelines should be simple to follow and consistent for all lesions irrespective of the location of the tumour. The recommendations were to place at least three spots of tattoo one mucosal fold distal to the lesion and clearly document site of tattoo with respect to tumour in the endoscopy report. We identified 100 patients undergoing elective laparoscopic colorectal cancer resections over a two-year period. Data were collected regarding presence of tattoo preoperatively as documented in the colonoscopy report and subsequently the visibility of the tattoo at time of laparoscopy and its accuracy in relation to the tumour. Abdominoperineal resections and emergency colorectal operations were excluded. Only 59% of the patients had a visible and accurate tattoo. In 17% of the patients, the tattoo was not visible at all, although it was documented in the endoscopy report that it had been administered. In 4% of patients, it was visible but inaccurately placed. In 20% of the patients, there were no tattoos at all, necessitating on table endoscopy and intraoperative specimen analysis to confirm that the tumour/lesion was within the resection specimen. Preoperative tumour localisation is extremely important to correctly identify the site of tumour or lesion at laparoscopy. A standardised departmental protocol should be implemented by all endoscopists to place three spots of tattoo one mucosal fold distal to any significant lesions found. Failure to tattoo lesions/cancers preoperatively can lead to intraoperative delays and

  13. EphB4 localises to the nucleus of prostate cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Mertens-Walker, Inga, E-mail: inga.mertenswalker@qut.edu.au [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Lisle, Jessica E. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Nyberg, William A. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Stephens, Carson R. [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia); Burke, Leslie [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Rutkowski, Raphael; Herington, Adrian C.; Stephenson, Sally-Anne [Institute of Health and Biomedical Innovation, Queensland University of Technology, Woolloongabba, QLD (Australia); Australian Prostate Cancer Research Centre—Queensland, Translational Research Institute, 37 Kent Street, Woolloongabba 4102, QLD (Australia)

    2015-04-10

    The EphB4 receptor tyrosine kinase is over-expressed in a variety of different epithelial cancers including prostate where it has been shown to be involved in survival, migration and angiogenesis. We report here that EphB4 also resides in the nucleus of prostate cancer cell lines. We used in silico methods to identify a bipartite nuclear localisation signal (NLS) in the extracellular domain and a monopartite NLS sequence in the intracellular kinase domain of EphB4. To determine whether both putative NLS sequences were functional, fragments of the EphB4 sequence containing each NLS were cloned to create EphB4NLS-GFP fusion proteins. Localisation of both NLS-GFP proteins to the nuclei of transfected cells was observed, demonstrating that EphB4 contains two functional NLS sequences. Mutation of the key amino residues in both NLS sequences resulted in diminished nuclear accumulation. As nuclear translocation is often dependent on importins we confirmed that EphB4 and importin-α can interact. To assess if nuclear EphB4 could be implicated in gene regulatory functions potential EphB4-binding genomic loci were identified using chromatin immunoprecipitation and Lef1 was confirmed as a potential target of EphB4-mediated gene regulation. These novel findings add further complexity to the biology of this important cancer-associated receptor. - Highlights: • The EphB4 protein can be found in the nucleus of prostate cancer cell lines. • EphB4 contains two functional nuclear localisation signals. • Chromatin immunoprecipitation has identified potential genome sequences to which EphB4 binds. • Lef1 is a confirmed target for EphB4-mediated gene regulation.

  14. Fabrication et caracterisation de nanocristaux de silicium localises, realises par gravure electrochimique pour des applications nanoelectroniques

    Science.gov (United States)

    Ayari-Kanoun, Asma

    Ce travail de these porte sur le developpement d'une nouvelle approche pour la localisation et l'organisation de nanocristaux de silicium realises par gravure electrochimique. Cette derniere represente une technique simple et peu couteuse par rapport aux autres techniques couramment utilisees pour la fabrication de nanocristaux de silicium. L'idee de ce travail a ete d'etudier la nanostructuration de minces couches de nitrure de silicium, d'environ 30 nm d'epaisseur pour permettre par la suite un arrangement periodique des nanocristaux de silicium. Cette pre-structuration est obtenue de facon artificielle en imposant un motif periodique via une technique de lithographie par faisceau d'electrons combinee avec une gravure plasma. Une optimisation des conditions de lithographie et de gravure plasma ont permis d'obtenir des reseaux de trous de 30 nm de diametre debouchant sur le silicium avec un bon controle de leur morphologie (taille, profondeur et forme). En ajustant les conditions de gravure electrochimique (concentration d'acide, temps de gravure et densite de courant), nous avons obtenu des reseaux -2D ordonnes de nanocristaux de silicium de 10 nm de diametre a travers ces masques de nanotrous avec le controle parfait de leur localisation, la distance entre les nanocristaux et leur orientation cristalline. Des etudes electriques preliminaires sur ces nanocristaux ont permis de mettre en evidence des effets de chargement. Ces resultats tres prometteurs confirment l'interet des nanocristaux de silicium realises par gravure electrochimique dans le futur pour la fabrication a grande echelle de dispositifs nanoelectroniques. Mots-cles : localisation, organisation, nanocristaux de silicium, gravure electrochimique, lithographie electronique, gravure plasma, nitrure de silicium.

  15. The non-equilibrium basis of Turing Instability and localised biological work.

    Science.gov (United States)

    Schiffmann, Yoram

    2017-08-01

    Turing's theory for biological pattern formation is based on the instability of the homogeneous state, which occurs if certain key criteria are met. The problem of how chemical energy is converted to localised biological work requires one to understand not only the basis of localised power generation, but also the age-old puzzle of how organisms decrease their entropy; these problems can only be solved by the identification of the Turing Instability. At the heart of this is how natural selection, not chemistry, has fashioned the large non-equilibrium overall affinity (ΔG is a large negative quantity) for the oxidation of the fuel molecules. Natural selection has also resulted in the homeostasis at non-equilibrium values of the hydrolysis of molecules like ATP, GTP, which are the energy links between the overall oxidation of the fuel and biological work. The conditions for such homeostasis are central requirements for the Turing Instability and are the essence of being alive. The Turing-Child (TC) patterns are the spontaneous primary spatial cause not only of localised biological work in multicellular systems (especially those in patterning and development) but also of intracellular patterns including the mitotic spindle and the contractile ring. The Turing picture comprises the nonuniform distribution of the concentrations of the Turing morphogens, cAMP and ATP, and the Child picture is the resulting nonuniform distribution of the metabolic rate and of power. The TC pattern is shaped as the dominant eigenfunction in the combination of eigenfunctions which provides the spatial pattern of the Turing morphogens. The TC patterns and the bifurcation parameter manifest quantisation and symmetry as in music and in applications of quantum mechanics. The notion of correlation diagrams is also introduced. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Effects of fuel Lewis number on localised forced ignition of turbulent homogeneous mixtures: A numerical investigation

    Directory of Open Access Journals (Sweden)

    Dipal Patel

    2016-09-01

    Full Text Available The influences of fuel Lewis number LeF (ranging from 0.8 to 1.2 on localised forced ignition and early stages of combustion of stoichiometric and fuel-lean homogeneous mixtures have been analysed using simple chemistry three-dimensional compressible direct numerical simulations for different values of root-mean-square velocity fluctuation and the energy deposition characteristics (i.e. characteristic width and the duration of energy deposition by the ignitor. The localised forced ignition is modelled using a source term in the energy transport equation, which deposits energy in a Gaussian manner from the centre of the ignitor over a stipulated period of time. The fuel Lewis number LeF has been found to have significant influences on the extent of burning of stoichiometric and fuel-lean homogeneous mixtures. It has been shown that the width of ignition energy deposition and the duration over which the ignition energy is deposited have significant influences on the success of ignition and subsequent flame propagation. An increase in the width of ignition energy deposition and the duration of energy deposition for a given amount of ignition energy have been found to have detrimental effects on the ignition event, which may ultimately lead to misfire. For a given value of u' (LeF, the rate of heat transfer from the hot gas kernel increases with increasing LeF (u', which in turn leads to a reduction in the extent of overall burning for both stoichiometric and fuel-lean homogeneous mixtures but the detrimental effects of high values of u' on localised forced ignition are particularly prevalent for fuel-lean mixtures. Detailed physical explanations have been provided for the observed LeF,u' and energy deposition characteristics effects.

  17. Advanced situation awareness with localised environmental community observatories in the Future Internet

    Science.gov (United States)

    Sabeur, Z. A.; Denis, H.; Nativi, S.

    2012-04-01

    The phenomenal advances in information and communication technologies over the last decade have led to offering unprecedented connectivity with real potentials for "Smart living" between large segments of human populations around the world. In particular, Voluntary Groups(VGs) and individuals with interest in monitoring the state of their local environment can be connected through the internet and collaboratively generate important localised environmental observations. These could be considered as the Community Observatories(CO) of the Future Internet(FI). However, a set of FI enablers are needed to be deployed for these communities to become effective COs in the Future Internet. For example, these communities will require access to services for the intelligent processing of heterogeneous data and capture of advancend situation awarness about the environment. This important enablement will really unlock the communities true potential for participating in localised monitoring of the environment in addition to their contribution in the creation of business entreprise. Among the eight Usage Areas(UA) projects of the FP7 FI-PPP programme, the ENVIROFI Integrated Project focuses on the specifications of the Future Internet enablers of the Environment UA. The specifications are developed under multiple environmental domains in context of users needs for the development of mash-up applications in the Future Internet. It will enable users access to real-time, on-demand fused information with advanced situation awareness about the environment at localised scales. The mash-up applications shall get access to rich spatio-temporal information from structured fusion services which aggregate COs information with existing environmental monitoring stations data, established by research organisations and private entreprise. These applications are being developed in ENVIROFI for the atmospheric, marine and biodiversity domains, together with a potential to be extended to other

  18. Localisation of primary food production in Finland: production potential and environmental impacts of food consumption patterns

    Directory of Open Access Journals (Sweden)

    H. RISKU-NORJA

    2008-12-01

    Full Text Available The potential for and environmental consequences of localising primary production of food were investigated by considering different food consumption patterns, based on conventional and organic production. Environmental impact was assessed according to agricultural land use and numbers of production animals, both of which depend on food consumption. The results were quantified in terms of nutrient balances, greenhouse gas and acid emissions and the diversity of crop cultivation, which indicate eutrophication of watersheds, climate change and landscape changes, respectively. The study region was able to satisfy its own needs for all farming and food consumption scenarios. Dietary choice had a marked impact on agricultural land use and on the environmental parameters considered. Organic farming for local food production resulted in higher greenhouse gas emissions. Compared with mixed diets, the vegetarian diet was associated with lower emissions and nutrient surpluses, but also with reduced crop diversity. The arable areas allocated to leys and pastures were also smaller. The study area represents a predominantly rural region and is a net exporter of agricultural produce. Therefore, only part of the environmental impact of food production results from local needs. Both the differences among the dietary options and the overall environmental benefit of localised primary food production were greatly reduced when considering total agricultural production of the region. Much of the negative impact of agriculture is due to food consumption in the densely populated urban areas, but the consequences are mainly felt in the production areas. The environmental impacts of localisation of primary food production for the rural areas are small and inconsistent. The results indicate the importance of defining ‘local’ on a regional basis and including the urban food sinks in impact assessment.;

  19. Fibre Tip Sensors for Localised Temperature Sensing Based on Rare Earth-Doped Glass Coatings

    Directory of Open Access Journals (Sweden)

    Erik P. Schartner

    2014-11-01

    Full Text Available We report the development of a point temperature sensor, based on monitoring upconversion emission from erbium:ytterbium-doped tellurite coatings on the tips of optical fibres. The dip coating technique allows multiple sensors to be fabricated simultaneously, while confining the temperature-sensitive region to a localised region on the end-face of the fibre. The strong response of the rare earth ions to changing temperature allows a resolution of 0.1–0.3 °C to be recorded over the biologically relevant range of temperatures from 23–39 °C.

  20. ROBUST LOCALISATION OF MULTIPLE SPEAKERS EXPLOITING HEAD MOVEMENTS AND MULTI-CONDITIONAL TRAINING OF BINAURAL CUES

    DEFF Research Database (Denmark)

    May, Tobias; Ma, Ning; Brown, Guy

    2015-01-01

    This paper addresses the problem of localising multiple competing speakers in the presence of room reverberation, where sound sources can be positioned at any azimuth on the horizontal plane. To reduce the amount of front-back confusions which can occur due to the sim- ilarity of interaural time...... differences (ITDs) and interaural level dif- ferences (ILDs) in the front and rear hemifield, a machine hearing system is presented which combines supervised learning of binaural cues using multi-conditional training (MCT) with a head movement strategy. A systematic evaluation showed that this approach...

  1. Intermittent Misfiring Default Detection and Localisation on a PWM Inverter Using Wavelet Decomposition

    Directory of Open Access Journals (Sweden)

    H. Ben Attia Sethom

    2008-06-01

    Full Text Available This paper presents a method to detect and localize intermittent misfiring default on a Pulse Width Modulation (PWM inverter supplying a squirrel cage induction machine. The proposed method is based on the Discrete Wavelet Transform (DWT technique to analyse stator current signals. The intermittent misfiring detection is performed thanks to the Daubechies wavelet mother in high frequency bands of the stator current signal. The localisation of the phase where the intermittent misfiring occurs is determined by a statistic approach. This approach is based on the computing of mean power characteristics of the detail signals which are obtained from the stator current wavelet decomposition.

  2. Vibration-based localisation of structural deterioration in frame-like civil engineering structures

    DEFF Research Database (Denmark)

    Ulriksen, Martin Dalgaard; Damkilde, Lars

    2016-01-01

    to other structural systems, for instance, wind turbines—can provide reliable damage localisation in frame-like structures. The performance of the method, which is based on statistical interrogation of changes in a surrogate of the transfer matrix, is tested in a Monte Carlo setting with a numerical steel......With the existing trend of minimising material use in typical frame-like civil engineering structures, such as buildings, bridges, and offshore platforms, these structures will typically be subjected to substantial wind induced vibrations. Besides being a source of disturbance for the occupants...... frame model subjected to white noise excitation....

  3. Les facteurs de localisation d’un nouveau type d’établissements tertiaires : les datacentres

    Directory of Open Access Journals (Sweden)

    Henry Bakis

    2015-02-01

    Full Text Available Les centres de traitement de données ou datacentres (data centers sont de nouveaux types d’établissements tertiaires rendus nécessaires par suite du développement d’Internet (sites web, cloud. Ils assurent notamment l’hébergement de serveurs (housing d’entreprises ou de particuliers en location ou colocation d’espaces. Cet article tente de présenter ce type d’établissements tertiaires et de mettre l’accent sur leurs enjeux en termes de localisation et d’environnement. Il met notamment l’accent sur leur consommation énergétique.

  4. Détection et localisation de défauts multiples par analyse en composantes principales

    OpenAIRE

    Tharrault, Yvon; HARKAT, Mohamed-Faouzi; Mourot, Gilles; Ragot, José

    2009-01-01

    National audience; L'Analyse en Composantes Principales (ACP) est une méthode réputée efficace pour la compression d'information. Cette communication présente l'utilisation de l'ACP pour la détection et la localisation de défauts multiples de mesures à partir d'un principe de reconstruction de variables et d'analyse des projections de ces reconstructions dans l'espace dit résiduel.

  5. How AI localisation in plant tissues determines the targeted pest spectrum of different chemistries

    DEFF Research Database (Denmark)

    Buchholz, Anke; Trapp, Stefan

    penetration as first crucial step can be modified by formulation whereas the active ingredient (AI) distribution within cells is usually solely determined by physicochemical properties. This passive AI distribution was calculated with the Fick-Nernst-Planck equation implemented in a cell model....... The predictions were compared to the measured biological effects against three different arthropods. Test compounds differed in log P (-0.1 to 4.3) and pKa (4.1 to 10.7). Efficacies in different bioassays are discussed with the postulated cellular AI localisation and the individual feeding behaviour...

  6. Estimation of the Ideal Binary Mask using Directional Systems

    DEFF Research Database (Denmark)

    Boldt, Jesper; Kjems, Ulrik; Pedersen, Michael Syskind

    2008-01-01

    The ideal binary mask is often seen as a goal for time-frequency masking algorithms trying to increase speech intelligibility, but the required availability of the unmixed signals makes it difficult to calculate the ideal binary mask in any real-life applications. In this paper we derive the theory...... and the requirements to enable calculations of the ideal binary mask using a directional system without the availability of the unmixed signals. The proposed method has a low complexity and is verified using computer simulation in both ideal and non-ideal setups showing promising results....

  7. Instant Adobe Edge Inspect starter

    CERN Document Server

    Khan, Joseph

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This easy-to-understand Starter guide will get you up to speed with Adobe Edge Inspect quickly and with little effort.This book is for frontend web developers and designers who are developing and testing web applications targeted for mobile browsers. It's assumed that you have a basic understanding of creating web applications using HTML, CSS, and JavaScript, as well as being familiar with running web pages from local HTTP servers. Readers are a

  8. Evaluation of an automatic MR-based gold fiducial marker localisation method for MR-only prostate radiotherapy

    Science.gov (United States)

    Maspero, Matteo; van den Berg, Cornelis A. T.; Zijlstra, Frank; Sikkes, Gonda G.; de Boer, Hans C. J.; Meijer, Gert J.; Kerkmeijer, Linda G. W.; Viergever, Max A.; Lagendijk, Jan J. W.; Seevinck, Peter R.

    2017-10-01

    An MR-only radiotherapy planning (RTP) workflow would reduce the cost, radiation exposure and uncertainties introduced by CT-MRI registrations. In the case of prostate treatment, one of the remaining challenges currently holding back the implementation of an RTP workflow is the MR-based localisation of intraprostatic gold fiducial markers (FMs), which is crucial for accurate patient positioning. Currently, MR-based FM localisation is clinically performed manually. This is sub-optimal, as manual interaction increases the workload. Attempts to perform automatic FM detection often rely on being able to detect signal voids induced by the FMs in magnitude images. However, signal voids may not always be sufficiently specific, hampering accurate and robust automatic FM localisation. Here, we present an approach that aims at automatic MR-based FM localisation. This method is based on template matching using a library of simulated complex-valued templates, and exploiting the behaviour of the complex MR signal in the vicinity of the FM. Clinical evaluation was performed on seventeen prostate cancer patients undergoing external beam radiotherapy treatment. Automatic MR-based FM localisation was compared to manual MR-based and semi-automatic CT-based localisation (the current gold standard) in terms of detection rate and the spatial accuracy and precision of localisation. The proposed method correctly detected all three FMs in 15/17 patients. The spatial accuracy (mean) and precision (STD) were 0.9 mm and 0.5 mm respectively, which is below the voxel size of 1.1 × 1.1 × 1.2 mm3 and comparable to MR-based manual localisation. FM localisation failed (3/51 FMs) in the presence of bleeding or calcifications in the direct vicinity of the FM. The method was found to be spatially accurate and precise, which is essential for clinical use. To overcome any missed detection, we envision the use of the proposed method along with verification by an observer. This will result in a

  9. Evaluation of an automatic MR-based gold fiducial marker localisation method for MR-only prostate radiotherapy.

    Science.gov (United States)

    Maspero, Matteo; van den Berg, Cornelis A T; Zijlstra, Frank; Sikkes, Gonda G; de Boer, Hans C J; Meijer, Gert J; Kerkmeijer, Linda G W; Viergever, Max A; Lagendijk, Jan J W; Seevinck, Peter R

    2017-10-03

    An MR-only radiotherapy planning (RTP) workflow would reduce the cost, radiation exposure and uncertainties introduced by CT-MRI registrations. In the case of prostate treatment, one of the remaining challenges currently holding back the implementation of an RTP workflow is the MR-based localisation of intraprostatic gold fiducial markers (FMs), which is crucial for accurate patient positioning. Currently, MR-based FM localisation is clinically performed manually. This is sub-optimal, as manual interaction increases the workload. Attempts to perform automatic FM detection often rely on being able to detect signal voids induced by the FMs in magnitude images. However, signal voids may not always be sufficiently specific, hampering accurate and robust automatic FM localisation. Here, we present an approach that aims at automatic MR-based FM localisation. This method is based on template matching using a library of simulated complex-valued templates, and exploiting the behaviour of the complex MR signal in the vicinity of the FM. Clinical evaluation was performed on seventeen prostate cancer patients undergoing external beam radiotherapy treatment. Automatic MR-based FM localisation was compared to manual MR-based and semi-automatic CT-based localisation (the current gold standard) in terms of detection rate and the spatial accuracy and precision of localisation. The proposed method correctly detected all three FMs in 15/17 patients. The spatial accuracy (mean) and precision (STD) were 0.9 mm and 0.5 mm respectively, which is below the voxel size of [Formula: see text] mm3 and comparable to MR-based manual localisation. FM localisation failed (3/51 FMs) in the presence of bleeding or calcifications in the direct vicinity of the FM. The method was found to be spatially accurate and precise, which is essential for clinical use. To overcome any missed detection, we envision the use of the proposed method along with verification by an observer. This will result in a

  10. How directional microphones affect speech recognition, listening effort and localisation for listeners with moderate-to-severe hearing loss.

    Science.gov (United States)

    Picou, Erin M; Ricketts, Todd A

    2017-12-01

    The purpose of this study was to evaluate the effects of directional microphone use on laboratory measures of sentence recognition, listening effort and localisation. An additional purpose of this study was to evaluate the effects of asymmetric directional microphone use on the same laboratory measures. Three hearing aid conditions were evaluated: (1) bilateral omnidirectional microphones, (2) bilateral directional microphones and (3) asymmetric microphones (directional microphone for only one hearing aid). Sentence recognition performance was evaluated using a connected speech test. Listening effort was evaluated using a dual-task paradigm with a response time-based secondary task requiring word categorisation. Localisation was examined using a complex task requiring localisation and recall of speech originating from one of four loudspeakers in the horizontal plane (-60°, -45°, +45°, +60°). Eighteen adults (M = 61.8 years) with symmetrical, moderate-to-severe hearing loss participated. Performance on each task was analysed separately using a repeated measures analysis of variance. Results revealed directional benefits for sentence recognition and listening effort, but microphone setting did not affect localisation. Performance was equivalent with symmetric and asymmetric directional configurations. Bilateral and asymmetric directional microphone configurations equally improved sentence recognition and listening effort; neither affected localisation or recall.

  11. Zigzag faceting and width refinement of graphene nanoribbons and nanoperforations via catalyzed edge-annealing on Cu(111)

    Science.gov (United States)

    Safron, Nathaniel S.; Choi, Jonathan W.; Kim, Myungwoong; Shin, Naechul; Gopalan, Padma; Arnold, Michael S.

    2015-12-01

    Top-down subtractive lithography has previously been used to pattern graphene nanostructures which lack ideal properties due to (1) limited resolution and (2) disordered edges. Here, we introduce a method to convert such disordered edges into relatively smooth zigzag edges via annealing on a Cu(111) substrate at ~950 °C. The Cu catalyzes the re-arrangement of graphene edge atoms to energetically favorable sites, inducing zigzag edge faceting. The dimensions of the graphene nanostructures can be increased, decreased, or held constant during the annealing by tuning the relative balance between growth and etching reactions, described by a fundamental growth rate equation. To demonstrate the flexibility of this method, we lithographically pattern graphene nanoribbons with zigzag or armchair orientations, or alternatively perforate graphene with circular holes, and then anneal these nanostructures to realize zigzag edge termination in each case, with nanostructure feature size tailored from 8 to 80 nm. The annealed nanostructures have smoother zigzag edges (~40% reduction in 1σ line edge roughness), and Raman spectroscopy confirms that they have lower edge disorder than top-down patterned samples.

  12. Effect of edge plasmons on the optical properties of MoS2 monolayer flakes

    DEFF Research Database (Denmark)

    Rossi, Tuomas P.; Winther, Kirsten Trøstrup; Jacobsen, Karsten Wedel

    2017-01-01

    . Thus, we observe that while an evenly-spaced edge configuration supports one-dimensional (1D) plasmon modes similar to those of an ideal 1D electron gas, the relaxed structures show mixed plasmon and single-electron excitations in the low-energy response. Our findings illustrate the sensitivity...

  13. How Forest Inhomogeneities Affect the Edge Flow

    DEFF Research Database (Denmark)

    Boudreault, Louis-Étienne; Dupont, Sylvain; Bechmann, Andreas

    2016-01-01

    Most of our knowledge on forest-edge flows comes from numerical and wind-tunnel experiments where canopies are horizontally homogeneous. To investigate the impact of tree-scale heterogeneities (>1 m) on the edge-flow dynamics, the flow in an inhomogeneous forest edge on Falster island in Denmark...... is investigated using large-eddy simulation. The three-dimensional forest structure is prescribed in the model using high resolution helicopter-based lidar scans. After evaluating the simulation against wind measurements upwind and downwind of the forest leading edge, the flow dynamics are compared between...... the scanned forest and an equivalent homogeneous forest. The simulations reveal that forest inhomogeneities facilitate flow penetration into the canopy from the edge, inducing important dispersive fluxes in the edge region as a consequence of the flow spatial variability. Further downstream from the edge...

  14. Reflections on the knife edge.

    Science.gov (United States)

    Murphy, John Patrick Michael; Chabner, Bruce A

    2011-01-01

    The accompanying article, written by John Murphy, a retired lawyer and lifelong outdoorsman from his beloved Colorado Rockies, draws the striking parallel between his experiences as a mountain climber and as a patient with metastatic melanoma facing the hope and uncertainty of experimental therapy. Both are life-threatening circumstances, demanding courage and hope, and challenging our soul in a way almost unique to human experience. Both involve a conscious choice to move forward into dangerous and uncertain territory, and require a determination to look death (John's "Reaper") in the eye. Many remarkable books and films have been written about such experiences. I recall in particular the 2003 documentary film Touching the Void, about the incredible survival of a mountaineer who returned from a perilous fall in Peru. I highly recommend it to the reader. Another is Laura Hillenbrand's Unbroken: A World War II Story of Survival, Resilience, and Redemption (Random House, 2010), about the survival of a prisoner of war, the celebrated miler Louis Zamperini. Again, unbridled courage and undeniable hope turned futility into future. John Murphy's reflections remind us of the daily heroism of our patients who are holding tight to the lifeline offered by clinical research. Good climbing, John. All of us are with you on that Knife Edge, waiting for our turn to ascend... and hoping to be as courageous as you were then on Capitol Peak and are again now on the Knife Edge of a clinical trial. For our turn will come.

  15. Ideal bandpasses for type Ia supernova cosmology

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Tamara M.; Schmidt, Brian P.; Kim, Alex G.

    2005-10-24

    To use type Ia supernovae as standard candles for cosmologywe need accurate broadband magnitudes. In practice the observed magnitudemay differ from the ideal magnitude-redshift relationship either throughintrinsic inhomogeneities in the type Ia supernova population or throughobservational error. Here we investigate how we can choose filterbandpasses to reduce the error caused by both these effects. We find thatbandpasses with large integral fluxes and sloping wings are best able tominimise several sources of observational error, and are also leastsensitive to intrinsic differences in type Ia supernovae. The mostimportant feature of a complete filter set for type Ia supernovacosmology is that each bandpass be a redshifted copy of the first. Wedesign practical sets of redshifted bandpasses that are matched totypical high resistivity CCD and HgCdTe infra-red detector sensitivities.These are designed to minimise systematic error in well observedsupernovae, final designs for specific missions should also considersignal-to-noise requirements and observing strategy. In addition wecalculate how accurately filters need to be calibrated in order toachieve the required photometric accuracy of future supernova cosmologyexperiments such as the SuperNova-Acceleration-Probe (SNAP), which is onepossible realisation of the Joint Dark-Energy mission (JDEM). We considerthe effect of possible periodic miscalibrations that may arise from theconstruction of an interference filter.

  16. Information, Entropy, and the Classical Ideal Gas

    Science.gov (United States)

    Sands, David; Dunning-Davies, Jeremy

    2013-09-01

    The physical basis of the canonical and grand canonical distributions is questioned. In particular, we question the usual methods by which these distributions are derived, namely that fluctuations in entropy around energy and particle number are assumed to occur when the entropy depends only on variables which cannot themselves fluctuate. We show, starting from the Maxwellian velocity distribution, that the probability that a classical ideal gas at a fixed temperature occupies a given energy state corresponds not to the canonical ensemble of classical statistical mechanics but to the Gamma distribution. Computer simulations of a hard-sphere fluid demonstrate the principles. The analysis is extended to open systems in which the number of particles fluctuates and we show that for a system connected to a particle reservoir the Poisson distribution governs the probability of finding a given number of particles. The resulting probability distributions are used to calculate the Shannon information entropy which is then compared with the thermodynamic entropy. We argue that information theoretic entropy and thermodynamic entropy, whilst related, are not necessarily identical and that the information entropy contains non-thermodynamic components.

  17. The loss of idealism throughout internship.

    Science.gov (United States)

    Griffith, Charles H; Wilson, John F

    2003-12-01

    The purpose of this project was to understand how resident attitudes to specific types of patients change throughout their internship. Over a 3-year period all 1st-year internal medicine residents were asked to complete a 15-item survey regarding their attitudes toward certain patient types and the profession. The survey was administered the 1st day of the internship, again in mid-November, and in June in the last month of internship. Sixty-one of 80 interns (76% response) completed all three administrations of the survey. In general, there were statistically significant differences in attitudes from the first administration to the second in all categories (all changes reflecting less idealism), with attitudes remaining the same for the second to third administration. For example, interns believed significantly more patients requesting narcotics were drug seekers (19% vs. 33%/37%, p < .0001) and a lesser percentage of the elderly could care for themselves independently (62% vs. 50%/48%, p < .0001). We conclude interns become less idealistic toward patients and the profession throughout internship, with the greatest change within the first 5 months.

  18. Ideal thermodynamic processes of oscillatory-flow regenerative engines will go to ideal stirling cycle?

    Science.gov (United States)

    Luo, Ercang

    2012-06-01

    This paper analyzes the thermodynamic cycle of oscillating-flow regenerative machines. Unlike the classical analysis of thermodynamic textbooks, the assumptions for pistons' movement limitations are not needed and only ideal flowing and heat transfer should be maintained in our present analysis. Under such simple assumptions, the meso-scale thermodynamic cycles of each gas parcel in typical locations of a regenerator are analyzed. It is observed that the gas parcels in the regenerator undergo Lorentz cycle in different temperature levels, whereas the locus of all gas parcels inside the regenerator is the Ericson-like thermodynamic cycle. Based on this new finding, the author argued that ideal oscillating-flow machines without heat transfer and flowing losses is not the Stirling cycle. However, this new thermodynamic cycle can still achieve the same efficiency of the Carnot heat engine and can be considered a new reversible thermodynamic cycle under two constant-temperature heat sinks.

  19. A full ranking for decision making units using ideal and anti-ideal points in DEA.

    Science.gov (United States)

    Barzegarinegad, A; Jahanshahloo, G; Rostamy-Malkhalifeh, M

    2014-01-01

    We propose a procedure for ranking decision making units in data envelopment analysis, based on ideal and anti-ideal points in the production possibility set. Moreover, a model has been introduced to compute the performance of a decision making unit for these two points through using common set of weights. One of the best privileges of this method is that we can make ranking for all decision making units by solving only three programs, and also solving these programs is not related to numbers of decision making units. One of the other advantages of this procedure is to rank all the extreme and nonextreme efficient decision making units. In other words, the suggested ranking method tends to seek a set of common weights for all units to make them fully ranked. Finally, it was applied for different sets holding real data, and then it can be compared with other procedures.

  20. Field topologies in ideal and near-ideal magnetohydrodynamics and vortex dynamics

    Science.gov (United States)

    Low, B. C.

    2015-01-01

    Magnetic field topology frozen in ideal magnetohydrodynamics (MHD) and its breakage in near-ideal MHD are reviewed in two parts, clarifying and expanding basic concepts. The first part gives a physically complete description of the frozen field topology derived from magnetic flux conservation as the fundamental property, treating four conceptually related topics: Eulerian and Lagrangian descriptions of three dimensional (3D) MHD, Chandrasekhar-Kendall and Euler-potential field representations, magnetic helicity, and inviscid vortex dynamics as a fluid system in physical contrast to ideal MHD. A corollary of these developments clarifies the challenge of achieving a high degree of the frozen-in condition in numerical MHD. The second part treats field-topology breakage centered around the Parker Magnetostatic Theorem on a general incompatibility of a continuous magnetic field with the dual demand of force-free equilibrium and an arbitrarily prescribed, 3D field topology. Preserving field topology as a global constraint readily results in formation of tangential magnetic discontinuities, or, equivalently, electric current-sheets of zero thickness. A similar incompatibility is present in the steady force-thermal balance of a heated radiating fluid subject to an anisotropic thermal flux conducted strictly along its frozen-in magnetic field in the low- β limit. In a weakly resistive fluid the thinning of current sheets by these general incompatibilities inevitably results in sheet dissipation, resistive heating and topological changes in the field notwithstanding the small resistivity. Strong Faraday induction drives but also macroscopically limits this mode of energy dissipation, trapping or storing free energy in self-organized ideal-MHD structures. This property of MHD turbulence captured by the Taylor hypothesis is reviewed in relation to the Sun's corona, calling for a basic quantitative description of the breakdown of flux conservation in the low-resistivity limit

  1. Vortical structures responsible for delayed stall in an idealized humpback whale flipper model

    Science.gov (United States)

    Kim, Heesu; Kim, Jooha; Choi, Haecheon

    2016-11-01

    In this study, we investigate how the tubercles on the leading edge of an idealized humpback whale flipper model delay the stall. Oil-surface visualization is performed to see the surface flow pattern on the suction surface, and PIV is conducted in several streamwise and crossflow planes at different attack angles (α). Without tubercles, leading edge separation first occurs near the tip region and progresses inboard with increasing α. With tubercles, however, two types of vortical motions are observed at the mid-span. The first is streamwise vortex arrays which are dominant at α 9° , and these structures appear near the trailing edge. These two types of vortical motions delay flow separation at the peak regions of the mid-span, eliminating the spanwise stall progression and resulting in delayed stall. At α = 16° at which the tubercle model stalls, a large-scale streamwise vortex is originated from flow separation near the root region. This structure delays flow separation at the mid-span, leading to higher lift coefficient. Supported by NRF-2014M3C1B1033848.

  2. Scintigraphic techniques in primary hyperparathyroidism: from pre-operative localisation to intra-operative imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rubello, Domenico [S. Maria della Misericordia Hospital, Service of Nuclear Medicine, Rovigo (Italy); Gross, Milton D. [Department of Veterans Affairs Health System, Nuclear Medicine Service, Ann Arbor, MI (United States); Mariani, Giuliano [University of Pisa, Regional Center of Nuclear Medicine, Pisa (Italy); Al-Nahhas, Adil [Hammersmith Hospital, Department of Nuclear Medicine, London (United Kingdom)

    2007-06-15

    Primary hyperparathyroidism (PHPT) is an increasingly diagnosed disease worldwide. In most cases, PHPT is related to the presence of a solitary parathyroid adenoma (PA). Fifty percent or more of newly diagnosed PHPT patients are asymptomatic, and there is debate among endocrinologists and endocrine surgeons about whether or not such patients should be treated. Usually, in a PHPT patient with a solitary PA that is well localised pre-operatively, a parathyroidectomy with limited or minimally invasive neck exploration is offered. The diffusion of minimally invasive neck exploration procedures is a consequence of the significant improvement in the accuracy of pre-operative imaging (mainly scintigraphic) techniques; these techniques have changed the surgical strategy to PHPT, from the wide traditional bilateral neck exploration to limited neck exploration. The present review considers developments during the past 10-15 years with regard to both the accuracy of pre-operative localising imaging techniques and intra-operative minimally invasive procedures in order to provide endocrinologists and endocrine surgeons with further information about the newly available diagnostic and therapeutic tools for use in PHPT patients with a solitary PA. (orig.)

  3. The Reduction of Vertical Interchannel Crosstalk: The Analysis of Localisation Thresholds for Natural Sound Sources

    Directory of Open Access Journals (Sweden)

    Rory Wallis

    2017-03-01

    Full Text Available In subjective listening tests, natural sound sources were presented to subjects as vertically-oriented phantom images from two layers of loudspeakers, ‘height’ and ‘main’. Subjects were required to reduce the amplitude of the height layer until the position of the resultant sound source matched that of the same source presented from the main layer only (the localisation threshold. Delays of 0, 1 and 10 ms were applied to the height layer with respect to the main, with vertical stereophonic and quadraphonic conditions being tested. The results of the study showed that the localisation thresholds obtained were not significantly affected by sound source or presentation method. Instead, the only variable whose effect was significant was interchannel time difference (ICTD. For ICTD of 0 ms, the median threshold was −9.5 dB, which was significantly lower than the −7 dB found for both 1 and 10 ms. The results of the study have implications both for the recording of sound sources for three-dimensional (3D audio reproduction formats and also for the rendering of 3D images.

  4. Organisation as a key factor in Localised Agri-Food Systems (LAFS

    Directory of Open Access Journals (Sweden)

    Corrado Giacomini

    2015-05-01

    Full Text Available Most studies of Localised Agri-Food Systems (LAFS focus on the localised concentration of members and firms, and pay less attention to organisational factors, particularly those of an exogenous nature. This paper focuses on the role of organisation in a LAFS, assessing the efficacy of EU organisational measures aimed at strengthening the concentration of supply from the recent CAP reform 2014-2020. The paper has three sections. Part One describes the evolution of the concept of LAFS. Part Two examines the leading role played by institutions in organising relationships between firms in a LAFS. The example provided is that of the measures affecting the organisation of supply introduced by the recent CAP reform, 2014-2020. It makes particular reference to the Distretto del pomodoro da industria – Nord Italia (‘Industrial Tomato District – Northern Italy’. Part Three describes how organisational factors can lead to the creation of a LAFS, while the criterion of proximity is necessary but not sufficient.

  5. New sites of localisation of Pasteurella multocida B:2 in buffalo surviving experimental haemorrhagic septicaemia.

    Science.gov (United States)

    Annas, Salleh; Zamri-Saad, Mohammad; Jesse, Faez Firdaus Abdullah; Zunita, Zakaria

    2014-04-11

    Haemorrhagic septicaemia (HS) is an acute septicaemic disease of buffalo and cattle caused by Pasteurella multocida B:2 and E:2. Field outbreaks of HS are known to result in localisation of bacteria in the tonsils of surviving buffalo, confirming that animals can become carriers and the role of respiratory tract in the transmission of the disease. This report describes additional sites of localisation of P. multocida B:2 in surviving buffalo following experimental induction of HS. Following P. multocida B:2 infection, all calves in group 1 and one calf in group 2 that was allowed to commingle with infected calves from group 1 were euthanised within 48 h. Pasteurella multocida B:2 was detected from the nasal and rectal swab samples on days 5 and 6 from the remaining calves in group 2. The first injection of dexamethasone into the carrier animals resulted in reemergence in samples from the nose, rectum and vagina. However, subsequent dexamethasone injections failed to re-activate P. multocida B:2. When surviving carrier calves in group 2 were euthanised at the end of the experiment, P. multocida B:2 was detected in the lungs and various organs of the respiratory, gastrointestinal and urinary tracts. Commingling naive buffalo calves with calves acutely infected with P. multocida B:2 resulted in carriers among surviving buffalo. Pasteurella was found in various organs of the respiratory, gastrointestinal and urinary tracts, suggesting their role in the pathogenesis of HS.

  6. Fear of new or recurrent melanoma after treatment for localised melanoma.

    Science.gov (United States)

    Bell, Katy J L; Mehta, Yachna; Turner, Robin M; Morton, Rachael L; Dieng, Mbathio; Saw, Robyn; Guitera, Pascale; McCaffery, Kirsten; Low, Donald; Low, Cynthia; Jenkins, Marisa; Irwig, Les; Webster, Angela C

    2017-11-01

    To estimate the amount of fear of new or recurrent melanoma among people treated for localised melanoma in an Australian specialist centre. We randomly selected 400 potential participants from all those treated for localised melanoma at the Melanoma Institute Australia during 2014 (n = 902). They were asked to complete an adapted version of the Fear of Cancer Recurrence Inventory (FCRI). We calculated summary statistics for demographics, clinical variables and total FCRI and subscale scores. Two hundred fifteen people (54%) completed the FCRI questionnaire. The overall mean severity subscale score was 15.0 (95% CI 14.0-16.1). A high proportion of participants had scores above a proposed threshold to screen for clinical fear of cancer recurrence (77% and 63% of participants with and without new or recurrent melanoma had severity subscale scores ≥13). Most participants also had scores above a threshold found to have high specificity for clinical fear of cancer recurrence (65% and 48% of participants with and without new or recurrent melanoma had severity subscale scores ≥16). The severity subscale appeared to discriminate well between groups with differing levels of risk of new or recurrent melanoma. There is a substantial amount of fear of new or recurrent melanoma among this population, despite most having a very good prognosis. Copyright © 2017 John Wiley & Sons, Ltd.

  7. Detection and cellular localisation of the synthetic soluble macromolecular drug carrier pHPMA

    Energy Technology Data Exchange (ETDEWEB)

    Kissel, Maria; Peschke, Peter; Strunz, Anke M.; Kuehnlein, Rainer; Debus, Juergen [Department of Radiation Oncology, E0505, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg (Germany); Subr, Vladimir; Ulbrich, Karel [Institute of Macromolecular Chemistry, Prague (Czech Republic); Friedrich, Eckhard [Division of Biology, University of Koblenz-Landau, Landau (Germany)

    2002-08-01

    Synthetic macromolecules such as copolymers of N-(2-hydroxypropyl)methacrylamide (pHPMA) are potential carriers for the delivery of drugs owing to their ability to passively accumulate in solid tumours [enhanced permeation and retention (EPR) effect]. To gain further knowledge about the biodistribution and the cellular localisation, poly(HPMA) was prepared for labelling by introducing biotin molecules. Biotinylated pHPMA (5 mol%) was intravenously injected into tumour-bearing rats and the accumulation of biotin-pHPMA was visualised using a streptavidin-alkaline phosphatase technique at day 7 post injection. In spite of the high solubility of pHPMA copolymers and the lack of attachment to cell structures, the biotinylated polymer could be easily detected in tissues fixed in 10% paraformaldehyde-phosphate buffer at 4 C for 48 h. While biotin-pHPMA could be detected intracytoplasmically in liver and spleen, a predominantly interstitial localisation was observed within the anaplastic prostate carcinoma (Dunning R3327-AT1). How biotin as a label influences the biodistribution of poly(HPMA) was assessed by scintigraphy, autoradiography and histology comparing homopolymer poly(HPMA) with biotin-pHPMA. The organ distribution patterns of the two polymers correlated well, except with respect to kidney. It is assumed that the accumulation of biotin-pHPMA in the distal tubuli is due to a biotin transporter in the brush border membrane. The technique presented is useful for a more comprehensive understanding of the biodistribution of soluble macromolecules. (orig.)

  8. A Review of Non-Invasive Techniques to Detect and Predict Localised Muscle Fatigue

    Science.gov (United States)

    Al-Mulla, Mohamed R.; Sepulveda, Francisco; Colley, Martin

    2011-01-01

    Muscle fatigue is an established area of research and various types of muscle fatigue have been investigated in order to fully understand the condition. This paper gives an overview of the various non-invasive techniques available for use in automated fatigue detection, such as mechanomyography, electromyography, near-infrared spectroscopy and ultrasound for both isometric and non-isometric contractions. Various signal analysis methods are compared by illustrating their applicability in real-time settings. This paper will be of interest to researchers who wish to select the most appropriate methodology for research on muscle fatigue detection or prediction, or for the development of devices that can be used in, e.g., sports scenarios to improve performance or prevent injury. To date, research on localised muscle fatigue focuses mainly on the clinical side. There is very little research carried out on the implementation of detecting/predicting fatigue using an autonomous system, although recent research on automating the process of localised muscle fatigue detection/prediction shows promising results. PMID:22163810

  9. Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains.

    Science.gov (United States)

    Bücherl, Christoph A; Jarsch, Iris K; Schudoma, Christian; Segonzac, Cécile; Mbengue, Malick; Robatzek, Silke; MacLean, Daniel; Ott, Thomas; Zipfel, Cyril

    2017-03-06

    Cell surface receptors govern a multitude of signalling pathways in multicellular organisms. In plants, prominent examples are the receptor kinases FLS2 and BRI1, which activate immunity and steroid-mediated growth, respectively. Intriguingly, despite inducing distinct signalling outputs, both receptors employ common downstream signalling components, which exist in plasma membrane (PM)-localised protein complexes. An important question is thus how these receptor complexes maintain signalling specificity. Live-cell imaging revealed that FLS2 and BRI1 form PM nanoclusters. Using single-particle tracking we could discriminate both cluster populations and we observed spatiotemporal separation between immune and growth signalling platforms. This finding was confirmed by visualising FLS2 and BRI1 within distinct PM nanodomains marked by specific remorin proteins and differential co-localisation with the cytoskeleton. Our results thus suggest that signalling specificity between these pathways may be explained by the spatial separation of FLS2 and BRI1 with their associated signalling components within dedicated PM nanodomains.

  10. Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif

    DEFF Research Database (Denmark)

    Jespersen, Thomas; Rasmussen, Hanne B; Grunnet, Morten

    2004-01-01

    KCNQ1 potassium channels are expressed in many epithelial tissues as well as in the heart. In epithelia KCNQ1 channels play an important role in salt and water transport and the channel has been reported to be located apically in some cell types and basolaterally in others. Here we show that KCNQ1...... channels are located basolaterally when expressed in polarised MDCK cells. The basolateral localisation of KCNQ1 is not affected by co-expression of any of the five KCNE beta-subunits. We characterise two independent basolateral sorting signals present in the N-terminal tail of KCNQ1. Mutation...... located protein, to the basolateral plasma membrane. Furthermore, a di-leucine-like motif at residues 38-40 (LEL) was found to affect the basolateral localisation of KCNQ1. Mutation of these two leucines resulted in a primarily intracellular localisation of the channel....

  11. Family Life and Developmental Idealism in Yazd, Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Jalal Abbasi-Shavazi

    2012-03-01

    Full Text Available BACKGROUND This paper is motivated by the theory that developmental idealism has been disseminated globally and has become an international force for family and demographic change. Developmental idealism is a set of cultural beliefs and values about development and how development relates to family and demographic behavior. It holds that modern societies are causal forces producing modern families, that modern families help to produce modern societies, and that modern family change is to be expected. OBJECTIVE We examine the extent to which developmental idealism has been disseminated in Iran. We also investigate predictors of the dissemination of developmental idealism. METHODS We use survey data collected in 2007 from a sample of women in Yazd, a city in Iran. We examine the distribution of developmental idealism in the sample and the multivariate predictors of developmental idealism. RESULTS We find considerable support for the expectation that many elements of developmental idealism have been widely disseminated. Statistically significant majorities associate development with particular family attributes, believe that development causes change in families, believe that fertility reductions and age-at-marriage increases help foster development, and perceive family trends in Iran headed toward modernity. As predicted, parental education, respondent education, and income affect adherence to developmental idealism. CONCLUSIONS Developmental idealism has been widely disseminated in Yazd, Iran and is related to social and demographic factors in predicted ways. COMMENTS Although our data come from only one city, we expect that developmental idealism has been widely distributed in Iran, with important implications for family and demographic behavior.

  12. Family Life and Developmental Idealism in Yazd, Iran.

    Science.gov (United States)

    Abbasi-Shavazi, Mohammad Jalal; Askari-Nodoushan, Abbas

    2012-01-01

    BACKGROUND: This paper is motivated by the theory that developmental idealism has been disseminated globally and has become an international force for family and demographic change. Developmental idealism is a set of cultural beliefs and values about development and how development relates to family and demographic behavior. It holds that modern societies are causal forces producing modern families, that modern families help to produce modern societies, and that modern family change is to be expected. OBJECTIVE: We examine the extent to which developmental idealism has been disseminated in Iran. We also investigate predictors of the dissemination of developmental idealism. METHODS: We use survey data collected in 2007 from a sample of women in Yazd, a city in Iran. We examine the distribution of developmental idealism in the sample and the multivariate predictors of developmental idealism. RESULTS: We find considerable support for the expectation that many elements of developmental idealism have been widely disseminated. Statistically significant majorities associate development with particular family attributes, believe that development causes change in families, believe that fertility reductions and age-at-marriage increases help foster development, and perceive family trends in Iran headed toward modernity. As predicted, parental education, respondent education, and income affect adherence to developmental idealism. CONCLUSIONS: Developmental idealism has been widely disseminated in Yazd, Iran and is related to social and demographic factors in predicted ways. COMMENTS: Although our data come from only one city, we expect that developmental idealism has been widely distributed in Iran, with important implications for family and demographic behavior.

  13. Three dimensional boundary displacement due to stable ideal kink modes excited by external n = 2 magnetic perturbations

    Science.gov (United States)

    Willensdorfer, M.; Strumberger, E.; Suttrop, W.; Dunne, M.; Fischer, R.; Birkenmeier, G.; Brida, D.; Cavedon, M.; Denk, S. S.; Igochine, V.; Giannone, L.; Kirk, A.; Kirschner, J.; Medvedeva, A.; Odstrčil, T.; Ryan, D. A.; The ASDEX Upgrade Team; The EUROfusion MST1 Team

    2017-11-01

    In low-collisionality (ν\\star) scenarios exhibiting mitigation of edge localized mode (ELMs), stable ideal kink modes at the edge are excited by externally applied magnetic perturbation (MP)-fields. In ASDEX Upgrade these modes can cause three-dimensional (3D) boundary displacements up to the centimeter range. These displacements have been measured using toroidally localized high resolution diagnostics and rigidly rotating n=2 MP-fields with various applied poloidal mode spectra. These measurements are compared to non-linear 3D ideal magnetohydrodynamics (MHD) equilibria calculated by VMEC. Comprehensive comparisons have been conducted, which consider for instance plasma movements due to the position control system, attenuation due to internal conductors and changes in the edge pressure profiles. VMEC accurately reproduces the amplitude of the displacement and its dependencies on the applied poloidal mode spectra. Quantitative agreement is found around the low field side (LFS) midplane. The response at the plasma top is qualitatively compared. The measured and predicted displacements at the plasma top maximize when the applied spectra is optimized for ELM-mitigation. The predictions from the vacuum modeling generally fails to describe the displacement at the LFS midplane as well as at the plasma top. When the applied mode spectra is set to maximize the displacement, VMEC and the measurements clearly surpass the predictions from the vacuum modeling by a factor of four. Minor disagreements between VMEC and the measurements are discussed. This study underlines the importance of the stable ideal kink modes at the edge for the 3D boundary displacement in scenarios relevant for ELM-mitigation.

  14. Background Modelling Using Edge-Segment Distributions

    Directory of Open Access Journals (Sweden)

    Jaemyun Kim

    2013-02-01

    Full Text Available We propose an edge-segment-based statistical background modelling algorithm to detect the moving edges for the detection of moving objects using a static camera. Traditional pixel intensity-based background modelling algorithms face difficulties in dynamic environments since they cannot handle sudden changes in illumination. They also bring out ghosts when a sudden change occurs in the scene. To cope with this issue, intensity and noise robust edge-based features have emerged. However, existing edge-pixel-based methods suffer from scattered moving edge pixels since they cannot utilize the shape. Moreover, traditional segment-based methods cannot handle edge shape variations and miss moving edges when they come close to the background edges. Unlike traditional approaches, our proposed method builds the background model from ordinary training frames that may contain moving objects. Furthermore, it does not leave any ghosts behind. Moreover, our method uses an automatic threshold for every background edge distribution for matching. This makes our approach robust to illumination change, camera movement and background motion. Experiments show that our method outperforms others and can detect moving edges efficiently despite the above mentioned difficulties.

  15. Koers and the ideal of Christian scholarship

    Directory of Open Access Journals (Sweden)

    Daniël F.M. Strauss

    2012-10-01

    Full Text Available Commemorating the 75-year existence of the journal Koers is connected to the Reformational tradition, from Calvin to Kuyper, Stoker, Dooyeweerd and Vollenhoven – all thinkers who realised that the biblical starting point of life indeed touches the heart, the religious root, of humankind and therefore cannot remain restricted to church life and religion in its narrow sense, but must come to expression in all walks of life. This awareness was a fruit of the Christian worldview and lifeview which currently is confronted by the Big Bang claims and by neo-Darwinism – both movements taking on cultic dimensions with an intolerance towards everyone who does not accept their perspective. Their attitude generated serious reactions on two websites, the impact of which was discussed in this article. Some problems entailed in Darwinism and physicalistic materialism were highlighted, before attention was given to the status of natural laws and normative principles. Particular attention was given to the elimination of God’s law and the way in which modern Humanism explored the two cornerstones of modern nominalism, up to the point where human understanding was elevated to become the a priori formal law-giver of nature. This legacy was continued both by the later developments within the Baden school of neo-Kantian thought and Postmodernism,which is placed within the context of the three succeeding epistemic ideals of the past three centuries. Rationality can only fulfil its true calling when it accounts for the cohering diversity within reality without becoming a victim of any form of reductionism – and by following this guiding star, Koers will continue to strengthen its invaluable contribution to the advancement of Christian scholarship.

  16. Ideal Adsorption Isotherm Behavior for Cooling Applications.

    Science.gov (United States)

    Bagheri, Morteza H; Schiffres, Scott N

    2018-01-24

    Purely heat-driven refrigeration has the potential for high primary-energy efficiency, especially when powered by waste heat or solar thermal sources. This paper presents a novel expression for the ideal adsorption step location as a function of operating conditions. This methodology is then applied to a hypothetical stepwise material to evaluate its intrinsic efficiency. This analysis technique is then extended to allow facile efficiency comparisons for any adsorbent-refrigerant pair using an adsorbent's isotherm and heat of adsorption properties. This work focuses on limitations to efficiency due to the equilibrium thermodynamics. It is found that a stepwise adsorbent can have a single-effect intrinsic efficiency of as high as about 85% of Carnot, assuming typical adsorbent specific heats and uptake capacity. Using these tools, we analyze the maximum ratio of cooling to heat input (coefficient of performance) for two adsorption pairs, zeolite 13X-water and UiO-66-water, which are found to have maximum coefficients of performance of 0.52 and 0.88 for a cold-side temperature of 10 °C and an ambient temperature of 30 °C, respectively. Meanwhile, the maximum fraction of Carnot cooling is 37% for zeolite 13X-water and 67% for UiO-66-water. Moreover, these peak fractions of Carnot occur at much higher regeneration temperatures for 13X (196 °C) than for UiO-66 (60 °C). These two materials could be coupled in a two-stage cascading triple-effect adsorption cycle that operates with a combined coefficient of performance of 1.50 at a regeneration temperature of 196 °C, a cold-side temperature of 10 °C, and an ambient temperature of 30 °C.

  17. [Ideal total hip prosthesis in 1993].

    Science.gov (United States)

    Delagoutte, J P; Mainard, D

    Although it is a hazardous adventure to define what is an ideal in any field, it would appear that there is a certain consensus about total hip prostheses. The fundamental principle of the total hip replacement was based on the articulation of a spheric segment, a mobile head contained in a hemispheric non-retaining element. To date, the first material is a titanium in a alloy containing 6% aluminum and 4% vanadium. The second material facing the titanium is polyethylene or alumine. Thus the joint couple could be "polyethylene-metal", or "polyethylene-alumine" or even "alumine-alumine". The hemispheric element can be a massive piece of polyethylene or formed by a peripheral metal (an open hemisphere) filled with the joint surface, itself made of polyethylene. This solution offers the possibility of changing the prosthesis in case of wear without interrupting the implant-bone contact. The first type is cemented to the bone with methyl polymethacrylate. With the second, the metallic part need not to be cemented and can be fitted to the bone by simple pressing. Several points are essential in the femoral piece. It should include a removable head so the length of the neck can be adjusted. It must fill the medullary canal as closely as possible and fill the methaphyseal space. It is fixed by a self-fitting system leading to stable secondary long-term fixation-a porous covering, sometimes with hydroxy apatite can also be useful. In certain cases it must be cemented, although the cement must only play the role of adaptation.(ABSTRACT TRUNCATED AT 250 WORDS)

  18. Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

    Science.gov (United States)

    Schaletzki, Yvonne; Kromrey, Marie-Luise; Bröderdorf, Susanne; Hammer, Elke; Grube, Markus; Hagen, Paul; Sucic, Sonja; Freissmuth, Michael; Völker, Uwe; Greinacher, Andreas; Rauch, Bernhard H; Kroemer, Heyo K; Jedlitschky, Gabriele

    2017-01-05

    The multidrug resistance protein 4 (MRP4/ABCC4) has been identified as an important transporter for signalling molecules including cyclic nucleotides and several lipid mediators in platelets and may thus represent a novel target to interfere with platelet function. Besides its localisation in the plasma membrane, MRP4 has been also detected in the membrane of dense granules in resting platelets. In polarised cells it is localised at the basolateral or apical plasma membrane. To date, the mechanism of MRP4 trafficking has not been elucidated; protein interactions may regulate both the localisation and function of this transporter. We approached this issue by searching for interacting proteins by in vitro binding assays, followed by immunoblotting and mass spectrometry, and by visualising their co-localisation in platelets and haematopoietic cells. We identified the PDZ domain containing scaffold proteins ezrin-binding protein 50 (EBP50/NHERF1), postsynaptic density protein 95 (PSD95), and sorting nexin 27 (SNX27), but also the adaptor protein complex 3 subunit β3A (AP3B1) and the heat shock protein HSP90 as putative interaction partners of MRP4. The knock-down of SNX27, PSD95, and AP3B1 by siRNA in megakaryoblastic leukaemia cells led to a redistribution of MRP4 from intracellular structures to the plasma membrane. Inhibition of HSP90 led to a diminished expression and retention of MRP4 in the endoplasmic reticulum. These results indicate that MRP4 localisation and function are regulated by multiple protein interactions. Changes in the adaptor proteins can hence lead to altered localisation and function of the transporter.

  19. Fukunaga-Koontz feature transformation for statistical structural damage detection and hierarchical neuro-fuzzy damage localisation

    Science.gov (United States)

    Hoell, Simon; Omenzetter, Piotr

    2017-07-01

    Considering jointly damage sensitive features (DSFs) of signals recorded by multiple sensors, applying advanced transformations to these DSFs and assessing systematically their contribution to damage detectability and localisation can significantly enhance the performance of structural health monitoring systems. This philosophy is explored here for partial autocorrelation coefficients (PACCs) of acceleration responses. They are interrogated with the help of the linear discriminant analysis based on the Fukunaga-Koontz transformation using datasets of the healthy and selected reference damage states. Then, a simple but efficient fast forward selection procedure is applied to rank the DSF components with respect to statistical distance measures specialised for either damage detection or localisation. For the damage detection task, the optimal feature subsets are identified based on the statistical hypothesis testing. For damage localisation, a hierarchical neuro-fuzzy tool is developed that uses the DSF ranking to establish its own optimal architecture. The proposed approaches are evaluated experimentally on data from non-destructively simulated damage in a laboratory scale wind turbine blade. The results support our claim of being able to enhance damage detectability and localisation performance by transforming and optimally selecting DSFs. It is demonstrated that the optimally selected PACCs from multiple sensors or their Fukunaga-Koontz transformed versions can not only improve the detectability of damage via statistical hypothesis testing but also increase the accuracy of damage localisation when used as inputs into a hierarchical neuro-fuzzy network. Furthermore, the computational effort of employing these advanced soft computing models for damage localisation can be significantly reduced by using transformed DSFs.

  20. Using Local Second Gradient Model and Shear Strain Localisation to Model the Excavation Damaged Zone in Unsaturated Claystone

    Science.gov (United States)

    Pardoen, Benoît; Levasseur, Séverine; Collin, Frédéric

    2015-03-01

    The drilling of galleries induces damage propagation in the surrounding medium and creates, around them, the excavation damaged zone (EDZ). The prediction of the extension and fracture structure of this zone remains a major issue, especially in the context of underground nuclear waste storage. Experimental studies on geomaterials indicate that localised deformation in shear band mode usually appears prior to fractures. Thus, the excavation damaged zone can be modelled by considering the development of shear strain localisation bands. In the classical finite element framework, strain localisation suffers a mesh-dependency problem. Therefore, an enhanced model with a regularisation method is required to correctly model the strain localisation behaviour. Among the existing methods, we choose the coupled local second gradient model. We extend it to unsaturated conditions and we include the solid grain compressibility. Furthermore, air ventilation inside underground galleries engenders a rock-atmosphere interaction that could influence the damaged zone. This interaction has to be investigated in order to predict the damaged zone behaviour. Finally, a hydro-mechanical modelling of a gallery excavation in claystone is presented and leads to a fairly good representation of the EDZ. The main objectives of this study are to model the fractures by considering shear strain localisation bands, and to investigate if an isotropic model accurately reproduces the in situ measurements. The numerical results provide information about the damaged zone extension, structure and behaviour that are in very good agreement with in situ measurements and observations. For instance, the strain localisation bands that develop in chevron pattern during the excavation and rock desaturation, due to air ventilation, are observed close to the gallery.

  1. Effect of edge plasmons on the optical properties of MoS2 monolayer flakes

    Science.gov (United States)

    Rossi, Tuomas P.; Winther, Kirsten T.; Jacobsen, Karsten W.; Nieminen, Risto M.; Puska, Martti J.; Thygesen, Kristian S.

    2017-10-01

    Finite MoS2 nanoparticles are known to support metallic edge states that are responsible for their catalytic activity. In this work we employ time-dependent density-functional theory (TDDFT) to study the influence of such edge states on the optical properties of triangular MoS2 monolayer flakes. We find that the edge states support collective plasmon-like excitations that couple strongly to the optical field leading to pronounced absorption peaks below the onset of interband transitions on the basal plane. Additionally, structural relaxation of the flakes can significantly distort the edge states. Thus, we observe that while an evenly-spaced edge configuration supports one-dimensional (1D) plasmon modes similar to those of an ideal 1D electron gas, the relaxed structures show mixed plasmon and single-electron excitations in the low-energy response. Our findings illustrate the sensitivity of the optical response of MoS2 nanostructures to the details of the edge configuration.

  2. Imaging edges of nanostructured graphene

    DEFF Research Database (Denmark)

    Kling, Jens; Cagliani, Alberto; Booth, T. J.

    Graphene, as the forefather of 2D-materials, attracts much attention due to its extraordinary properties like transparency, flexibility and outstanding high conductivity, together with a thickness of only one atom. However, graphene also possesses no band gap, which makes it unsuitable for many...... electronic applications like transistors. It has been shown theoretically that by nanostructuring pristine graphene, e.g. with regular holes, the electronic properties can be tuned and a band gap introduced. The size, distance and edge termination of these “defects” influence the adaptability....... Such nanostructuring can be done experimentally, but especially characterization at atomic level is a huge challenge. High-resolution TEM (HRTEM) is used to characterize the atomic structure of graphene. We optimized the imaging conditions used for the FEI Titan ETEM. To reduce the knock-on damage of the carbon atoms...

  3. At the edge of intonation

    DEFF Research Database (Denmark)

    Niebuhr, Oliver

    2012-01-01

    The paper is concerned with the 'edge of intonation' in a twofold sense. It focuses on utterance-final F0 movements and crosses the traditional segment-prosody divide by investigating the interplay of F0 and voiceless fricatives in speech production. An experiment was performed for German with four...... types of voiceless fricatives: /f/, /s/, /ʃ/ and /x/. They were elicited with scripted dialogues in the contexts of terminal falling statement and high rising question intonations. Acoustic analyses show that fricatives concluding the high rising question intonations had higher mean centres of gravity...... (CoGs), larger CoG ranges and higher noise energy levels than fricatives concluding the terminal falling statement intonations. The different spectral-energy patterns are suitable to induce percepts of a high 'aperiodic pitch' at the end of the questions and of a low 'aperiodic pitch' at the end...

  4. Organization of crop and animal production in dairy farms localised in three chosen regions of lubelskie voivodeship

    Directory of Open Access Journals (Sweden)

    Jolanta Bojarszczuk

    2010-01-01

    Full Text Available The evaluation of organization of crop and animal production in dairy farms localised in three regions in Lubelskie voivodeship was presented in the paper. The data source was questionnaire research. The study was trained in 145 farms. The provided analysis showed that cereals had significantly share in pattern system in tested farms. Researched farms are differentiated of occupied differentiation of cropping pattern and density livestock between farms localised in different regions of Lubelskie voivodeship caused different level of intensity of organization animal and crops production. The differentiation of indicators was especially significant between farms in Krasnystaw and Ryki.

  5. Human perception of indoor environment generated by chilled ceiling combined with mixing ventilation or localised chilled beam under cooling mode

    DEFF Research Database (Denmark)

    Bolashikov, Zhecho Dimitrov; Nygaard, Linette; Uth, Simon C.

    2014-01-01

    Experiments with 24 subjects were performed to study and compare the human perception of the indoor environment under summer conditions generated by a chilled ceiling combined with overhead mixing ventilation and localised chilled beam. The experiments were performed in an experimental chamber (4....../s during the 20 min period of physical activity, when the occupant was not at the desk with the localised chilled beam, resulting in increase of the air temperature in the room. Subjects used questionnaires to answer on thermal sensation and acceptability, perceived air quality, air movement and SBS...

  6. Regulation processes in intimate relationships: the role of ideal standards.

    Science.gov (United States)

    Overall, Nickola C; Fletcher, Garth J O; Simpson, Jeffry A

    2006-10-01

    This research investigated the consistency between partner perceptions and ideal standards (ideal-perception consistency) and the partner regulation attempts of 200 individuals involved in relationships (Study 1) and 62 heterosexual couples (Study 2). As predicted, greater regulation attempts were associated with lower ideal-perception consistency, and these links operated within 3 pivotal mate-evaluation dimensions and were moderated by perceived regulation success. Ideal-perception consistency also mediated the relation between partner regulation and relationship quality, and cross-lagged analyses suggested that ideal consistency and regulation influenced each other over time. Finally, stronger partner regulation was generally associated with more negative self-evaluations and more self-regulation by the targeted partner. These novel results support and extend the Ideal Standards Model (J. A. Simpson, G. J. O. Fletcher, & L. Campbell, 2001). 2006 APA, all rights reserved

  7. Correction of edge-flame propagation speed in a counterflow, annular slot burner

    KAUST Repository

    Tran, Vu Manh

    2015-10-22

    To characterize the propagation modes of flames, flame propagation speed must be accurately calculated. The impact of propagating edge-flames on the flow fields of unburned gases is limited experimentally. Thus, few studies have evaluated true propagation speeds by subtracting the flow velocities of unburned gases from flame displacement speeds. Here, we present a counterflow, annular slot burner that provides an ideal one-dimensional strain rate and lengthwise zero flow velocity that allowed us to study the fundamental behaviors of edge-flames. In addition, our burner has easy optical access for detailed laser diagnostics. Flame displacement speeds were measured using a high-speed camera and related flow fields of unburned gases were visualized by particle image velocimetry. These techniques allowed us to identify significant modifications to the flow fields of unburned gases caused by thermal expansion of the propagating edges, which enabled us to calculate true flame propagation speeds that took into account the flow velocities of unburned gases.

  8. Gyrofluid computation of magnetic perturbation effects on turbulence and edge localized bursts

    Science.gov (United States)

    Peer, J.; Kendl, A.; Ribeiro, T. T.; Scott, B. D.

    2017-08-01

    The effects of non-axisymmetric resonant magnetic perturbation fields (RMPs) on saturated drift-wave turbulence and on ballooning mode bursts in the edge pedestal of tokamak plasmas are investigated by numerical simulations with a nonlinear six-moment electromagnetic gyrofluid model including zonal profile evolution. The vacuum RMP fields are screened by plasma response currents, so that magnetic transport by perturbed parallel motion is not significantly changed. Radial transport of both particles and heat is dominated by turbulent convection even for large RMP amplitudes, where formation of quasi-stationary convective structures leads to edge profile degradation. Modelling of ideal ballooning mode unstable edge profiles for single bursts including RMP fields causes resonant mode locking and destabilization.

  9. Object detection using categorised 3D edges

    DEFF Research Database (Denmark)

    Kiforenko, Lilita; Buch, Anders Glent; Bodenhagen, Leon

    2015-01-01

    is made possible by the explicit use of edge categories in the feature descriptor. We quantitatively compare our approach with the state-of-the-art template based Linemod method, which also provides an effective way of dealing with texture-less objects, tests were performed on our own object dataset. Our......In this paper we present an object detection method that uses edge categorisation in combination with a local multi-modal histogram descriptor, all based on RGB-D data. Our target application is robust detection and pose estimation of known objects. We propose to apply a recently introduced edge...... categorisation algorithm for describing objects in terms of its different edge types. Relying on edge information allow our system to deal with objects with little or no texture or surface variation. We show that edge categorisation improves matching performance due to the higher level of discrimination, which...

  10. Tanning beauty ideals among Swedish adults who exercise regularly

    OpenAIRE

    Cedercreutz, Isabella

    2016-01-01

    Tanning beauty ideals among Swedish adults who exercise regularly Introduction: The majority of the Swedish population exercise regularly, and it has been reported that they believe having an attractive body is important. While research has shown that Swedes wish to be tanned, it is unknown whether there are any correlations to their exercise habits. Aims: The primary aim was to determine tanned skin tone ideals and tanning beauty ideals among regularly exercising Swedish adults. Associati...

  11. Converging cylindrical shocks in ideal magnetohydrodynamics

    KAUST Repository

    Pullin, D. I.

    2014-09-01

    We consider a cylindrically symmetrical shock converging onto an axis within the framework of ideal, compressible-gas non-dissipative magnetohydrodynamics (MHD). In cylindrical polar co-ordinates we restrict attention to either constant axial magnetic field or to the azimuthal but singular magnetic field produced by a line current on the axis. Under the constraint of zero normal magnetic field and zero tangential fluid speed at the shock, a set of restricted shock-jump conditions are obtained as functions of the shock Mach number, defined as the ratio of the local shock speed to the unique magnetohydrodynamic wave speed ahead of the shock, and also of a parameter measuring the local strength of the magnetic field. For the line current case, two approaches are explored and the results compared in detail. The first is geometrical shock-dynamics where the restricted shock-jump conditions are applied directly to the equation on the characteristic entering the shock from behind. This gives an ordinary-differential equation for the shock Mach number as a function of radius which is integrated numerically to provide profiles of the shock implosion. Also, analytic, asymptotic results are obtained for the shock trajectory at small radius. The second approach is direct numerical solution of the radially symmetric MHD equations using a shock-capturing method. For the axial magnetic field case the shock implosion is of the Guderley power-law type with exponent that is not affected by the presence of a finite magnetic field. For the axial current case, however, the presence of a tangential magnetic field ahead of the shock with strength inversely proportional to radius introduces a length scale R = √μ0/p0 I/(2π) where I is the current, μ0 is the permeability, and p0 is the pressure ahead of the shock. For shocks initiated at r ≫ R, shock convergence is first accompanied by shock strengthening as for the strictly gas-dynamic implosion. The diverging magnetic field then

  12. Engineering the Ideal Gigapixel Image Viewer

    Science.gov (United States)

    Perpeet, D. Wassenberg, J.

    2011-09-01

    Despite improvements in automatic processing, analysts are still faced with the task of evaluating gigapixel-scale mosaics or images acquired by telescopes such as Pan-STARRS. Displaying such images in ‘ideal’ form is a major challenge even today, and the amount of data will only increase as sensor resolutions improve. In our opinion, the ideal viewer has several key characteristics. Lossless display - down to individual pixels - ensures all information can be extracted from the image. Support for all relevant pixel formats (integer or floating point) allows displaying data from different sensors. Smooth zooming and panning in the high-resolution data enables rapid screening and navigation in the image. High responsiveness to input commands avoids frustrating delays. Instantaneous image enhancement, e.g. contrast adjustment and image channel selection, helps with analysis tasks. Modest system requirements allow viewing on regular workstation computers or even laptops. To the best of our knowledge, no such software product is currently available. Meeting these goals requires addressing certain realities of current computer architectures. GPU hardware accelerates rendering and allows smooth zooming without high CPU load. Programmable GPU shaders enable instant channel selection and contrast adjustment without any perceptible slowdown or changes to the input data. Relatively low disk transfer speeds suggest the use of compression to decrease the amount of data to transfer. Asynchronous I/O allows decompressing while waiting for previous I/O operations to complete. The slow seek times of magnetic disks motivate optimizing the order of the data on disk. Vectorization and parallelization allow significant increases in computational capacity. Limited memory requires streaming and caching of image regions. We develop a viewer that takes the above issues into account. Its awareness of the computer architecture enables previously unattainable features such as smooth

  13. Selective Electroless Silver Deposition on Graphene Edges

    DEFF Research Database (Denmark)

    Durhuus, D.; Larsen, M. V.; Andryieuski, Andrei

    2015-01-01

    We demonstrate a method of electroless selective silver deposition on graphene edges or between graphene islands without covering the surface of graphene. Modifications of the deposition recipe allow for decoration of graphene edges with silver nanoparticles or filling holes in damaged graphene...... on silica substrate and thus potentially restoring electric connectivity with minimal influence on the overall graphene electrical and optical properties. The presented technique could find applications in graphene based transparent conductors as well as selective edge functionalization and can be extended...

  14. Particle number counting statistics in ideal Bose gases

    National Research Council Canada - National Science Library

    Christoph Weiss; Martin Wilkens

    1997-01-01

    We discuss the exact particle number counting statistics of degenerate ideal Bose gases in the microcanonical, canonical, and grand-canonical ensemble, respectively, for various trapping potentials...

  15. Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation.

    Directory of Open Access Journals (Sweden)

    Maria Vittoria Barone

    Full Text Available BACKGROUND: Celiac Disease (CD is both a frequent disease (1:100 and an interesting model of a disease induced by food. It consists in an immunogenic reaction to wheat gluten and glutenins that has been found to arise in a specific genetic background; however, this reaction is still only partially understood. Activation of innate immunity by gliadin peptides is an important component of the early events of the disease. In particular the so-called "toxic" A-gliadin peptide P31-43 induces several pleiotropic effects including Epidermal Growth Factor Receptor (EGFR-dependent actin remodelling and proliferation in cultured cell lines and in enterocytes from CD patients. These effects are mediated by delayed EGFR degradation and prolonged EGFR activation in endocytic vesicles. In the present study we investigated the effects of gliadin peptides on the trafficking and maturation of endocytic vesicles. METHODS/PRINCIPAL FINDINGS: Both P31-43 and the control P57-68 peptide labelled with fluorochromes were found to enter CaCo-2 cells and interact with the endocytic compartment in pulse and chase, time-lapse, experiments. P31-43 was localised to vesicles carrying early endocytic markers at time points when P57-68-carrying vesicles mature into late endosomes. In time-lapse experiments the trafficking of P31-43-labelled vesicles was delayed, regardless of the cargo they were carrying. Furthermore in celiac enterocytes, from cultured duodenal biopsies, P31-43 trafficking is delayed in early endocytic vesicles. A sequence similarity search revealed that P31-43 is strikingly similar to Hrs, a key molecule regulating endocytic maturation. A-gliadin peptide P31-43 interfered with Hrs correct localisation to early endosomes as revealed by western blot and immunofluorescence microscopy. CONCLUSIONS: P31-43 and P57-68 enter cells by endocytosis. Only P31-43 localises at the endocytic membranes and delays vesicle trafficking by interfering with Hrs

  16. Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms

    Directory of Open Access Journals (Sweden)

    Goud Bruno

    2009-08-01

    Full Text Available Abstract Background The Golgi apparatus in mammals appears as a ribbon made up of interconnected stacks of flattened cisternae that is positioned close to the centrosome in a microtubule-dependent manner. How this organisation is achieved and retained is not well understood. GMAP210 is a long coiled-coil cis-Golgi associated protein that plays a role in maintaining Golgi ribbon integrity and position and contributes to the formation of the primary cilium. An amphipathic alpha-helix able to bind liposomes in vitro has been recently identified at the first 38 amino acids of the protein (amphipathic lipid-packing sensor motif, and an ARF1-binding domain (Grip-related Arf-binding domain was found at the C-terminus. To which type of membranes these two GMAP210 regions bind in vivo and how this contributes to GMAP210 localisation and function remains to be investigated. Results By using truncated as well as chimeric mutants and videomicroscopy we found that both the N-terminus and the C-terminus of GMAP210 are targeted to the cis-Golgi in vivo. The ALPS motif was identified as the N-terminal binding motif and appeared concentrated in the periphery of Golgi elements and between Golgi stacks. On the contrary, the C-terminal domain appeared uniformly distributed in the cis-cisternae of the Golgi apparatus. Strikingly, the two ends of the protein also behave differently in response to the drug Brefeldin A. The N-terminal domain redistributed to the endoplasmic reticulum (ER exit sites, as does the full-length protein, whereas the C-terminal domain rapidly dissociated from the Golgi apparatus to the cytosol. Mutants comprising the full-length protein but lacking one of the terminal motifs also associated with the cis-Golgi with distribution patterns similar to those of the corresponding terminal end whereas a mutant consisting in fused N- and C-terminal ends exhibits identical localisation as the endogenous protein. Conclusion We conclude that the Golgi

  17. Evaluation of specimen preparation techniques for micro-PIXE localisation of elements in hyperaccumulating plants

    Energy Technology Data Exchange (ETDEWEB)

    Kachenko, Anthony G. [Faculty of Agriculture, Food and Natural Resources, University of Sydney, New South Wales 2006 (Australia)], E-mail: a.kachenko@usyd.edu.au; Siegele, Rainer; Bhatia, Naveen P. [Institute for Environmental Research, Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales 2234 (Australia); Singh, Balwant [Faculty of Agriculture, Food and Natural Resources, University of Sydney, New South Wales 2006 (Australia); Ionescu, Mihail [Institute for Environmental Research, Australian Nuclear Science and Technology Organization, Lucas Heights, New South Wales 2234 (Australia)

    2008-04-15

    Hybanthus floribundus subsp. floribundus, a rare Australian Ni-hyperaccumulating shrub and Pityrogramma calomelanos var. austroamericana, an Australian naturalized As-hyperaccumulating fern are promising species for use in phytoremediation of contaminated sites. Micro-proton-induced X-ray emission ({mu}-PIXE) spectroscopy was used to map the elemental distribution of the accumulated metal(loid)s, Ca and K in leaf or pinnule tissues of the two plant species. Samples were prepared by two contrasting specimen preparation techniques: freeze-substitution in tetrahydrofuran (THF) and freeze-drying. The specimens were analysed to compare the suitability of each technique in preserving (i) the spatial elemental distribution and (ii) the tissue structure of the specimens. Further, the {mu}-PIXE results were compared with concentration of elements in the bulk tissue obtained by ICP-AES analysis. In H. floribundus subsp. floribundus, {mu}-PIXE analysis revealed Ni, Ca and K concentrations in freeze-dried leaf tissues were at par with bulk tissue concentrations. Elemental distribution maps illustrated that Ni was preferentially localised in the adaxial epidermal tissues (1% DW) and least concentration was found in spongy mesophyll tissues (0.53% DW). Conversely, elemental distribution maps of THF freeze-substituted tissues indicated significantly lower Ni, Ca and K concentrations than freeze-dried specimens and bulk tissue concentrations. Moreover, Ni concentrations were uniform across the whole specimen and no localisation was observed. In P. calomelanos var. austroamericana freeze-dried pinnule tissues, {mu}-PIXE revealed statistically similar As, Ca and K concentrations as compared to bulk tissue concentrations. Elemental distribution maps showed that As localisation was relatively uniform across the whole specimen. Once again, THF freeze-substituted tissues revealed a significant loss of As compared to freeze-dried specimens and the concentrations obtained by bulk tissue

  18. Topological edge states of bound photon pairs

    Science.gov (United States)

    Gorlach, Maxim A.; Poddubny, Alexander N.

    2017-05-01

    We predict the existence of interaction-driven edge states of bound two-photon quasiparticles in a dimer periodic array of nonlinear optical cavities. The energy spectrum of photon pairs is dramatically richer than in the noninteracting case or in a simple lattice, featuring collapse and revival of multiple edge and bulk modes as well as edge states in continuum. We link the edge-state existence to the two-photon quantum walk graph connectivity. Our results offer a route to control quantum entanglement and provide insights into the physics of many-body topological states.

  19. Chiral edge fluctuations of colloidal membranes

    Science.gov (United States)

    Jia, Leroy; Zakhary, Mark; Dogic, Zvonimir; Pelcovits, Robert; Powers, Thomas

    Using experiments and theory we study chiral fluctuations of the edge of a nearly flat colloidal membrane, consisting of rod-like viruses held together by the depletion interaction. Our measurements show an anomalous peak in the power spectrum around 1 inverse micron. Using an effective theory to describe the liquid crystal degrees of freedom by geometric properties of the edge, such as length, geodesic torsion, and curvature, we calculate the spectrum of out-of-plane edge fluctuations. The peak arises for sufficiently strong chirality, and corresponds to the instability of a flat membrane to a shape with helical, rippled edges.

  20. Selective edge enhancement using anisotropic vortex filter.

    Science.gov (United States)

    Sharma, Manoj Kumar; Joseph, Joby; Senthilkumaran, Paramasivam

    2011-09-20

    In optical image processing, selective edge enhancement is important when it is preferable to emphasize some edges of an object more than others. We propose a new method for selective edge enhancement of amplitude objects using the anisotropic vortex phase mask by introducing anisotropy in a conventional vortex mask with the help of the sine function. The anisotropy is capable of edge enhancement in the selective region and in the required direction by changing the power and offset angle, respectively, of the sine function.

  1. Edge passivation induced single-edge ferromagnetism of zigzag MoS{sub 2} nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Rui; Sun, Hui; Ma, Ben; Hu, Jingguo, E-mail: jghu@yzu.edu.cn; Pan, Jing, E-mail: panjing_yz@163.com

    2017-01-30

    We performed density functional theory study on electronic structure, magnetic properties and stability of zigzag MoS{sub 2} nanoribbons (ZMoS{sub 2}NRs) with and without oxygen (O) passivation. The bare ZMoS{sub 2}NRs are magnetic metal with ferromagnetic edge states, edge passivation decreases their magnetism because of the decrease of edge unsaturated electrons. Obviously, the electronic structure and magnetic properties of ZMoS{sub 2}NRs greatly depend on edge states. When both edges are passivated by O atoms, ZMoS{sub 2}NRs are nonmagnetic metals. When either edge is passivated by O atoms, the systems exhibit single-edge ferromagnetism and magnetism concentrates on the non-passivated edge. Edge passivation can not only tune the magnetism of ZMoS{sub 2}NRs, but also enhance their stability by eliminating dangling bonds. These interesting findings on ZMoS{sub 2}NRs may open the possibility of their application in nanodevices and spintronics. - Highlights: • Edge passivation for tuning magnetism of zigzag MoS{sub 2} nanoribbons (ZMoS{sub 2}NRs) is proposed. • Edge passivation can tune ZMoS{sub 2}NRs from nonmagnetic metal to ferromagnetic metal. • When either edge is passivated, the systems exhibit single-edge ferromagnetic states. • These findings may inspire great interest in the community of ZMoS{sub 2}NRs and motivate numerous experimental researches.

  2. Experimental testing of spanwise morphing trailing edge concept

    Science.gov (United States)

    Pankonien, Alexander; Inman, Daniel J.

    2013-04-01

    Aircraft wings with smooth, hinge-less morphing ailerons exhibit increased chordwise aerodynamic efficiency over conventional hinged ailerons. Ideally, the wing would also use these morphing ailerons to smoothly vary its airfoil shape between spanwise stations to optimize the lift distribution and further increase aerodynamic efficiency. However, the mechanical complexity or added weight of achieving such a design has traditionally exceeded the potential aerodynamic gains. By expanding upon the previously developed cascading bimorph concept, this work uses embedded Macro-Fiber Composites and a flexure box mechanism, created using multi-material 3D printing, to achieve the Spanwise Morphing Trailing Edge (SMTE) concept. The morphing actuators are spaced spanwise along the wing with an elastomer spanning the gaps between them, which allows for optimization of the spanwise lift distribution while maintaining the continuity and efficiency of the morphing trailing edge. The concept is implemented in a representative section of a UAV wing with a 305 mm chord. A novel honeycomb skin is created from an elastomeric material using a 3D printer. The actuation capabilities of the concept are evaluated with and without spanning material on a test stand, free of aerodynamic loads. In addition, the actuation restrictions of the spanning elastomer, necessary in adapting the morphing concept from 2D to 3D, are characterized. Initial aerodynamic results from the 1'×1' wind-tunnel also show the effects of aerodynamic loading on the actuation range of the SMTE concept for uniform morphing.

  3. Experimental investigation of trailing edge noise from stationary and rotating airfoils.

    Science.gov (United States)

    Zajamsek, Branko; Doolan, Con J; Moreau, Danielle J; Fischer, Jeoffrey; Prime, Zebb

    2017-05-01

    Trailing edge noise from stationary and rotating NACA 0012 airfoils is characterised and compared with a noise prediction based on the semi-empirical Brooks, Pope, and Marcolini (BPM) model. The NACA 0012 is symmetrical airfoil with no camber and 12% thickness to chord length ratio. Acoustic measurements were conducted in an anechoic wind tunnel using a stationary NACA 0012 airfoil at 0° pitch angle. Airfoil self-noise emissions from rotating NACA 0012 airfoils mounted at 0° and 10° pitch angles on a rotor-rig are studied in an anechoic room. The measurements were carried out using microphone arrays for noise localisation and magnitude estimation using beamforming post-processing. Results show good agreement between peak radiating trailing edge noise emissions of stationary and rotating NACA 0012 airfoils in terms of the Strouhal number. Furthermore, it is shown that noise predictions based on the BPM model considering only two dimensional flow effects, are in good agreement with measurements for rotating airfoils, at these particular conditions.

  4. Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands

    DEFF Research Database (Denmark)

    Fahrenkrug, Jan; Hannibal, Jens

    2011-01-01

    PACAP (pituitary adenylate cyclase activating polypeptide) is widely distributed neuropeptide acting via three subtypes of receptors, PAC(1), VPAC(1) and VPAC(2). Here we examined the localisation and nature of PACAP-immunoreactive nerves in the rat thyroid and parathyroid glands and defined...... the distribution of PAC(1), VPAC(1) and VPAC(2) receptor mRNA's. In the parathyroid gland a large number of nerve fibres displaying PACAP-immunoreactivity were distributed beneath the capsule, around blood vessels and close to glandular cells. Most of the PACAP-nerves were sensory, since they co-stored CGRP...... (calcitonin-gene-related peptide) and were sensitive to capsaicin-treatment. mRNA's for PAC(1) and VPAC(2) receptors occurred in the parathyroid gland, mainly located in the glandular cells. In the thyroid gland PACAP-immunoreactive nerve fibres were associated with blood vessels, thyroid follicles...

  5. Pre-operative localisation of hyperfunctional parathyroid tissue with {sup 11}C-methionine PET

    Energy Technology Data Exchange (ETDEWEB)

    Otto, D.; Boerner, A.R.; Hofmann, M.; Brunkhorst, T.; Meyer, G.J.; Petrich, T.; Knapp, W.H. [Hannover University Medical School, Department of Nuclear Medicine, Hannover (Germany); Scheumann, G.F. [Hannover University Medical School, Department of Visceral and Transplant Surgery, Hannover (Germany)

    2004-10-01

    Previous studies have shown high sensitivity of positron emission tomography (PET) with {sup 11}C-methionine in the pre-operative localisation of parathyroid adenoma and hyperplasia. Nonetheless, in secondary and tertiary hyperparathyroidism (HPT) and in patients with recurrent disease, pre-operative localisation of adenomatous (PTA) or hyperplastic tissue is still a problem with all available methods. The aim of this study was to define the optimal imaging protocol and to compare the diagnostic value of {sup 11}C-methionine PET and {sup 99m}Tc-methoxyisobutylisonitrile (MIBI) single-photon emission computed tomography (SPECT): in particular, we wished to define the benefit of {sup 11}C-methionine in those patients with inconclusive or negative conventional imaging. Thirty highly pre-selected patients with HPT were enrolled. Sixteen patients had primary HPT, 12 patients had secondary HPT, and two patients had recurrences of parathyroid carcinomas. All patients had ultrasound of the neck, dual-phase scintigraphy with {sup 99m}Tc-MIBI and PET with {sup 11}C-methionine. SUV{sub parathyroid}/SUV{sub cervical} {sub soft} {sub tissue} (target-to-background) and SUV{sub parathyroid} {sub tissue}/SUV{sub thyroid} {sub tissue} (target-to-non-target) ratios were calculated. After surgery, histology of specimens was obtained in all patients but one. In 12 patients with secondary or tertiary HPT, 36 hyperplastic parathyroid glands were histologically verified. Twenty-five of 36 lesions (69%) were detected with {sup 11}C-methionine PET and 17 (47%) with {sup 99m}Tc-MIBI scintigraphy. PET studies were positive in 17/18 (94%) cases in which HPT was related to adenomas or carcinomas. {sup 99m}Tc-MIBI scintigraphy/SPECT yielded pathological lesions in 9/18 cases (50%). All eight atypical localisations of parathyroid glands were detected with PET but only six of the eight were detected with {sup 99m}Tc-MIBI scintigraphy/SPECT. In 10/11 patients with recurrent HPT and non

  6. Optimisation of platelet concentrates therapy: Composition, localisation, and duration of action

    Directory of Open Access Journals (Sweden)

    Yuk-Lin Yung

    2017-01-01

    Full Text Available Platelet concentrates (PC generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future.

  7. Segmental Spinal Muscular Atrophy Localised to the Lower Limbs : First case from Oman

    Directory of Open Access Journals (Sweden)

    Roshan Koul

    2017-08-01

    Full Text Available Spinal muscular atrophy (SMA is a genetic lower motor neuron disease. It usually involves all of the skeletal muscles innervated by the anterior horn cells of the spinal cord. In rare cases, there is also localised involvement of the spinal cord. We report a 10-year-old boy who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in 2015 with muscle weakness restricted to the lower limbs. The presence of a homozygous deletion within the survival of motor neuron 1 gene confirmed the diagnosis of SMA. To the best of the authors’ knowledge, this is the first report of an Omani patient with segmental SMA involving only the lower limbs. Treatment for this rare and relatively benign form of SMA is symptomatic and includes physiotherapy.

  8. Separation and Localisation of P300 Sources and Their Subcomponents Using Constrained Blind Source Separation

    Science.gov (United States)

    Spyrou, Loukianos; Jing, Min; Sanei, Saeid; Sumich, Alex

    2006-12-01

    Separation and localisation of P300 sources and their constituent subcomponents for both visual and audio stimulations is investigated in this paper. An effective constrained blind source separation (CBSS) algorithm is developed for this purpose. The algorithm is an extension of the Infomax BSS system for which a measure of distance between a carefully measured P300 and the estimated sources is used as a constraint. During separation, the proposed CBSS method attempts to extract the corresponding P300 signals. The locations of the corresponding sources are then estimated with some indeterminancy in the results. It can be seen that the locations of the sources change for a schizophrenic patient. The experimental results verify the statistical significance of the method and its potential application in the diagnosis and monitoring of schizophrenia.

  9. Ablative therapy for people with localised prostate cancer: a systematic review and economic evaluation.

    Science.gov (United States)

    Ramsay, Craig R; Adewuyi, Temitope E; Gray, Joanne; Hislop, Jenni; Shirley, Mark D F; Jayakody, Shalmini; MacLennan, Graeme; Fraser, Cynthia; MacLennan, Sara; Brazzelli, Miriam; N'Dow, James; Pickard, Robert; Robertson, Clare; Rothnie, Kieran; Rushton, Stephen P; Vale, Luke; Lam, Thomas B

    2015-07-01

    For people with localised prostate cancer, active treatments are effective but have significant side effects. Minimally invasive treatments that destroy (or ablate) either the entire gland or the part of the prostate with cancer may be as effective and cause less side effects at an acceptable cost. Such therapies include cryotherapy, high-intensity focused ultrasound (HIFU) and brachytherapy, among others. This study aimed to determine the relative clinical effectiveness and cost-effectiveness of ablative therapies compared with radical prostatectomy (RP), external beam radiotherapy (EBRT) and active surveillance (AS) for primary treatment of localised prostate cancer, and compared with RP for salvage treatment of localised prostate cancer which has recurred after initial treatment with EBRT. MEDLINE (1946 to March week 3, 2013), MEDLINE In-Process & Other Non-Indexed Citations (29 March 2013), EMBASE (1974 to week 13, 2013), Bioscience Information Service (BIOSIS) (1956 to 1 April 2013), Science Citation Index (1970 to 1 April 2013), Cochrane Central Register of Controlled Trials (CENTRAL) (issue 3, 2013), Cochrane Database of Systematic Reviews (CDSR) (issue 3, 2013), Database of Abstracts of Reviews of Effects (DARE) (inception to March 2013) and Health Technology Assessment (HTA) (inception to March 2013) databases were searched. Costs were obtained from NHS sources. Evidence was drawn from randomised controlled trials (RCTs) and non-RCTs, and from case series for the ablative procedures only, in people with localised prostate cancer. For primary therapy, the ablative therapies were cryotherapy, HIFU, brachytherapy and other ablative therapies. The comparators were AS, RP and EBRT. For salvage therapy, the ablative therapies were cryotherapy and HIFU. The comparator was RP. Outcomes were cancer related, adverse effects (functional and procedural) and quality of life. Two reviewers extracted data and carried out quality assessment. Meta-analysis used a Bayesian

  10. Localisation on Sasaki-Einstein manifolds from holomorphic functions on the cone

    Energy Technology Data Exchange (ETDEWEB)

    Schmude, Johannes [Department of Physics, Universidad de Oviedo, Avda. Calvo Sotelo 18, 33007, Oviedo (Spain)

    2015-01-22

    We study super Yang-Mills theories on five-dimensional Sasaki-Einstein manifolds. Using localisation techniques, we find that the contribution from the vector multiplet to the perturbative partition function can be calculated by counting holomorphic functions on the associated Calabi-Yau cone. This observation allows us to use standard techniques developed in the context of quiver gauge theories to obtain explicit results for a number of examples; namely S{sup 5}, T{sup 1,1}, Y{sup 7,3}, Y{sup 2,1}, Y{sup 2,0}, and Y{sup 4,0}. We find complete agreement with previous results obtained by Qiu and Zabzine using equivariant indices except for the orbifold limits Y{sup p,0} with p>1.

  11. Globalisation, localisation and implications of a transforming nursing workforce in New Zealand: opportunities and challenges.

    Science.gov (United States)

    Callister, Paul; Badkar, Juthika; Didham, Robert

    2011-09-01

    Severe staff and skill shortages within the health systems of developed countries have contributed to increased migration by health professionals. New Zealand stands out among countries in the Organisation for Economic Co-operation and Development in terms of the high level of movements in and out of the country of skilled professionals, including nurses. In New Zealand, much attention has been given to increasing the number of Māori and Pacific nurses as one mechanism for improving Māori and Pacific health. Against a backdrop of the changing characteristics of the New Zealand nursing workforce, this study demonstrates that the globalisation of the nursing workforce is increasing at a faster rate than its localisation (as measured by the growth of the Māori and New Zealand-born Pacific workforces in New Zealand). This challenges the implementation of culturally appropriate nursing programmes based on the matching of nurse and client ethnicities. © 2011 Blackwell Publishing Ltd.

  12. Breast lesion co-localisation between X-ray and MR images using finite element modelling.

    Science.gov (United States)

    Lee, Angela W C; Rajagopal, Vijayaraghavan; Babarenda Gamage, Thiranja P; Doyle, Anthony J; Nielsen, Poul M F; Nash, Martyn P

    2013-12-01

    This paper presents a novel X-ray and MR image registration technique based on individual-specific biomechanical finite element (FE) models of the breasts. Information from 3D magnetic resonance (MR) images was registered to X-ray mammographic images using non-linear FE models subject to contact mechanics constraints to simulate the large compressive deformations between the two imaging modalities. A physics-based perspective ray-casting algorithm was used to generate 2D pseudo-X-ray projections of the FE-warped 3D MR images. Unknown input parameters to the FE models, such as the location and orientation of the compression plates, were optimised to provide the best match between the pseudo and clinical X-ray images. The methods were validated using images taken before and during compression of a breast-shaped phantom, for which 12 inclusions were tracked between imaging modalities. These methods were then applied to X-ray and MR images from six breast cancer patients. Error measures (such as centroid and surface distances) of segmented tumours in simulated and actual X-ray mammograms were used to assess the accuracy of the methods. Sensitivity analysis of the lesion co-localisation accuracy to rotation about the anterior-posterior axis was then performed. For 10 of the 12 X-ray mammograms, lesion localisation accuracies of 14 mm and less were achieved. This analysis on the rotation about the anterior-posterior axis indicated that, in cases where the lesion lies in the plane parallel to the mammographic compression plates, that cuts through the nipple, such rotations have relatively minor effects.This has important implications for clinical applicability of this multi-modality lesion registration technique, which will aid in the diagnosis and treatment of breast cancer. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Extended pelvic lymphadenectomy in patients with clinically localised prostate cancer: A prospective observational study.

    Science.gov (United States)

    Ramos, J G; Caicedo, J I; Cataño, J G; Villarraga, L G; Trujillo, C G; Robledo, D; Plata, M

    2016-09-01

    To determine the frequency of lymph node involvement in patients with clinically localised prostate adenocarcinoma who had radical prostatectomy and extended pelvic lymphadenectomy. A prospective observational study was conducted on 137 patients with clinically localised prostate cancer of low, intermediate or high risk according to the D'Amico classification. All participants underwent radical prostatectomy plus extended pelvic lymphadenectomy in 3 reference centres in Bogota, Colombia, between 2013 and 2014. The following variables were assessed: age, prostate specific antigen levels, Gleason score of the biopsy, probability of lymph node involvement calculated with Partin tables and the histopathology result of the surgical specimen, with the definitive Gleason pattern and the total number of resected and involved lymph nodes per tumour, according to the territory of the dissection. A total of 2,876 lymph nodes were extracted (an average of 20.99 lymph nodes per patient). There was lymph node involvement in 14 (10.22%) patients. The high-risk and intermediate-risk group presented lymph node metastases in 28.57% and 5.25%, respectively. There was no lymph node involvement in the low-risk group. Of the patients at risk of lymph node involvement (≥2% according to the Partin tables), 19.40% had lymph node metastases. Lymph node involvement in our population is similar to that reported in the worldwide literature. Extended pelvic lymphadenectomy increased the probability of detecting lymph node metastases in our community. Copyright © 2016 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

  14. Localised proton magnetic resonance spectroscopy of the brain after perinatal hypoxia: a preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    Chateil, J.F. [Service de Radiologie A, Hopital Pellegrin, Bordeaux (France)]|[Unite de Radiopediatrie, Hopital Pellegrin, Bordeaux (France); Quesson, B.; Thiaudiere, E.; Delalande, C.; Canioni, P. [Resonance Magnetique des Systemes Biologiques, CNRS, Bordeaux (France); Brun, M.; Diard, F. [Service de Radiologie A, Hopital Pellegrin, Bordeaux (France); Sarlangue, J.; Billeaud, C. [Service de Neonatalogie, Hopital Pellegrin, Bordeaux (France)

    1999-03-01

    Objectives. Perinatal hypoxic ischaemic injury is a significant cause of neurodevelopmental impairment. The aim of this study was to evaluate localised proton magnetic resonance spectroscopy ({sup 1}H-MRS) after birth asphyxia. Materials and methods. Thirty newborn infants suspected of having perinatal asphyxia (Apgar score < 3) were studied. The mean gestational age was 37 weeks, mean age at the MR examination was 18 days and mean weight was 2.9 kg. A 1.5-T unit was used for imaging and spectroscopy. None of the babies had mechanically assisted ventilation. No sedation was used. Axial T1-weighted and T2-weighted images were obtained. {sup 1}H-MRS was recorded in a single voxel, localised in white matter, using a STEAM sequence. Results. Image quality was good in 25 of 30 babies. {sup 1}H-MRS was performed in 19 of 30 subjects, with adequate quality in 16. Choline, creatine/phosphocreatine and N-acetylaspartate peaks and peak-area ratios were analysed. Lactate was detected in four infants. The N-acetylaspartate/choline ratio was lower in infants with an impaired neurological outcome, but the difference was not statistically significant. Conclusions. This study suggests that {sup 1}H-MRS may be useful for assessing cerebral metabolism in the neonate. A raised lactate level and decreased N-acetylaspartate/choline ratio may be predictive of a poor outcome. However, in our experience this method is limited by the difficulty in performing the examination during the first hours after birth in critically ill babies, the problems related to use of a monovoxel sequence, the dispersion of the ratios and the lack of determination of the absolute concentration of the metabolites. (orig.) With 3 figs., 2 tabs., 20 refs.

  15. Histochemical localisation of carbonic anhydrase in the inner ear of developing cichlid fish, Oreochromis mossambicus

    Science.gov (United States)

    Beier, M.; Hilbig, R.; Anken, R.

    2008-12-01

    Inner ear otolith growth in terms of mineralisation mainly depends on the enzyme carbonic anhydrase (CAH). CAH is located in specialised, mitochondria-rich macular cells (ionocytes), which are involved in the endolymphatic ion exchange, and the enzyme is responsible for the provision of the pH-value necessary for otolithic calcium carbonate deposition. In the present study, for the first time the localisation of histochemically demonstrated CAH was analysed during the early larval development of a teleost, the cichlid fish Oreochromis mossambicus. CAH-reactivity was observed already in stage 7 animals (onset of otocyst development; staging follows Anken et al. [Anken, R., Kappel, T., Slenzka, K., Rahmann, H. The early morphogenetic development of the cichlid fish, Oreochromis mossambicus (Perciformes, Teleostei). Zool. Anz. 231, 1-10, 1993]). Neuroblasts (from which sensory and supporting cells are derived) proved to be CAH-positive. Already at stage 12 (hatch), CAH-positive regions could be attributed to ionocyte containing regions both in the so-called meshwork and patches area of the macula (i.e., clearly before ionocytes can be identified on ultrastructural level or by employing immunocytochemistry). In contrast to the circumstances observed in mammalian species, sensory hair cells stained negative for CAH in the cichlid. With the onset of stage 16 (finray primordia in dorsal fin, yolk-sac being increasingly absorbed), CAH-reactivity was observed in the vestibular nerve. This indicates the onset of myelinisation and thus commencement of operation. The localisation of CAH in the inner ear of fish (especially the differences in comparison to mammals) is discussed on the basis of its role in otolith calcification. Since the vestibular system is a detector of acceleration and thus gravity, also aspects regarding effects of altered gravity on CAH and hence on the mineralisation of otoliths in an adaptive process are addressed.

  16. Magnetic resonance spectroscopy as a decision tool in multimodality treatment design for localised prostate cancer

    Directory of Open Access Journals (Sweden)

    Giuseppe Sasso

    2011-12-01

    Full Text Available Predicting the outcome of individual prostate adenocarcinoma can be challenging, especially for patients affected by intermediate or high risk, but localised disease. Natural histories of prostate cancers with similar stage and prognostic factors can differ significantly; and an ongoing debate surrounds the optimal treatment choice for men diagnosed with non-metastatic prostate cancer. A variety of effective therapeutic options are available to be used as a sole modality, or in combination, including surgery, external beam radiotherapy, brachytherapy, and endocrine manipulation. Although these treatments have been used routinely for more than 15 years, there is a paucity of data from randomised trials comparing their results. In addition, most treatment techniques have changed dramatically in the last two decades due to the ongoing healthcare technological revolution. The rapid proliferation of new and expensive therapeutic options (i.e. adaptive radiotherapy, focal ablation, etc. promises to minimise treatment related side effects and improve local control, however, there is no uniform consensus. Treatment choice is based on the available prognostic factors and life expectancy, along with patient preference, toxicity profiles, the individual institution’s (and clinician’s experience and resource availability. Unfortunately, our prognostic tools are still limited, as is our ability to precisely predict which subset of patients might benefit from more aggressive therapeutic combinations. Therefore, a significant number of patients receive unnecessary and expensive treatments, whilst others are denied highly technological procedures because of associated resource limitation. This paper aims to analyse the current evidence, cost-effectiveness and controversies, surrounding the nonsurgical treatment of localised prostate cancer, with a focus on radiation and endocrine therapies, and to discuss the role of magnetic resonance spectroscopy, as a

  17. The influence of wire localisation for non-palpable breast lesions on visualisation of the sentinel node

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, J.E.; Bekker, J.; Verberne, G.H.M. [Meander Medical Center, Department of Surgery, Amersfoort (Netherlands); Haas, M.J. de; Weel, F.A. van der; Quekel, L.G.B.A. [Meander Medical Center, Department of Nuclear Medicine and Radiology, Amersfoort (Netherlands); Budel, L.M. [Meander Medical Center, Department of Pathology, Amersfoort (Netherlands); Klerk, J.M.H. de [Meander Medical Center, Department of Nuclear Medicine and Radiology, Amersfoort (Netherlands); University Medical Center Utrecht, Department of Nuclear Medicine, Utrecht (Netherlands)

    2006-11-15

    In our clinic, patients with occult breast lesions are treated with a sentinel node biopsy combined with wire-guided tumour excision. The aim of this retrospective study was to determine the influence of the sequence of wire localisation and sentinel node procedure on visualisation of the sentinel node. A total of 136 patients had a wire-guided tumour excision combined with a sentinel node procedure. Sixty-six patients had guide wire localisation prior to the sentinel node procedure. Seventy patients had sentinel node visualisation before insertion of the guide wire. The sentinel node was visualised in 41 (62%) of the patients who first underwent guide wire localisation. In the group of patients who underwent visualisation of the sentinel node before placement of the guide wire, the sentinel node was visualised in 62 (89%). This is a significant difference in visualisation (p<0.001). This study shows that guide wire localisation prior to the sentinel node procedure negatively influences visualisation of the sentinel node. (orig.)

  18. Assessment of localisation to auditory stimulation in post-comatose states: use the patient’s own name

    Science.gov (United States)

    2013-01-01

    Background At present, there is no consensus on how to clinically assess localisation to sound in patients recovering from coma. We here studied auditory localisation using the patient’s own name as compared to a meaningless sound (i.e., ringing bell). Methods Eighty-six post-comatose patients diagnosed with a vegetative state/unresponsive wakefulness syndrome or a minimally conscious state were prospectively included. Localisation of auditory stimulation (i.e., head or eyes orientation toward the sound) was assessed using the patient’s own name as compared to a ringing bell. Statistical analyses used binomial testing with bonferroni correction for multiple comparisons. Results 37 (43%) out of the 86 studied patients showed localisation to auditory stimulation. More patients (n=34, 40%) oriented the head or eyes to their own name as compared to sound (n=20, 23%; ppatient’s own name is here shown to be more suitable to elicit a response as compared to neutral sound. PMID:23506054

  19. Collaborations between Foreign-Invested Enterprises and China's VET Schools: Making the System Work amid Localised Skill Shortages

    Science.gov (United States)

    Li, Yiqiong; Sheldon, Peter

    2014-01-01

    This article examines collaborative initiatives individual foreign-invested enterprises (FIEs) develop with China's vocational education and training (VET) schools amid localised shortages of skilled workers. It thus focuses on employer initiatives in responding to VET system weaknesses rather than, as is common, those weaknesses. Using Suzhou…

  20. Tissue level, activation and cellular localisation of TGF-β1 and association with survival in gastric cancer patients

    NARCIS (Netherlands)

    Hawinkels, L.J.A.C.; Verspaget, H.W.; Duijn, W. van; Zon, J.M. van der; Zuidwijk, K.; Kubben, F.J.G.M.; Verheijen, J.H.; Hommes, D.W.; Lamers, C.B.H.W.; Sier, C.F.M.

    2007-01-01

    Transforming growth factor-β1 (TGF-β1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-β1 activation and localisation of TGF-β1 activity in gastric cancer. Gastric tumours showed increased stromal and epithelial

  1. Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells

    Energy Technology Data Exchange (ETDEWEB)

    Peddie, Christopher J.; Blight, Ken; Wilson, Emma [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Melia, Charlotte [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Department of Molecular Cell Biology, Leiden University Medical Centre, 2300 RC Leiden (Netherlands); Marrison, Jo [Department of Biology, The University of York, Heslington, York (United Kingdom); Carzaniga, Raffaella [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Domart, Marie-Charlotte [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); O' Toole, Peter [Department of Biology, The University of York, Heslington, York (United Kingdom); Larijani, Banafshe [Cell Biophysics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom); Cell Biophysics Laboratory, Unidad de Biofísica (CSIC-UPV/EHU),Sarriena s/n, 48940 Leioa (Spain); IKERBASQUE, Basque Foundation for Science, Bilbao (Spain); Collinson, Lucy M. [Electron Microscopy Unit, London Research Institute, Cancer Research UK, London WC2A 3LY (United Kingdom)

    2014-08-01

    Fluorescence microscopy of GFP-tagged proteins is a fundamental tool in cell biology, but without seeing the structure of the surrounding cellular space, functional information can be lost. Here we present a protocol that preserves GFP and mCherry fluorescence in mammalian cells embedded in resin with electron contrast to reveal cellular ultrastructure. Ultrathin in-resin fluorescence (IRF) sections were imaged simultaneously for fluorescence and electron signals in an integrated light and scanning electron microscope. We show, for the first time, that GFP is stable and active in resin sections in vacuo. We applied our protocol to study the subcellular localisation of diacylglycerol (DAG), a modulator of membrane morphology and membrane dynamics in nuclear envelope assembly. We show that DAG is localised to the nuclear envelope, nucleoplasmic reticulum and curved tips of the Golgi apparatus. With these developments, we demonstrate that integrated imaging is maturing into a powerful tool for accurate molecular localisation to structure. - Highlights: • GFP and mCherry fluorescence are preserved in heavy-metal stained mammalian cells embedded in resin • Fluorophores are stable and intensity is sufficient for detection in ultrathin sections • Overlay of separate LM and EM images from the same ultrathin section improves CLEM protein localisation precision • GFP is stable and active in the vacuum of an integrated light and scanning EM • Integrated light and electron microscopy shows new subcellular locations of the lipid diacylglycerol.

  2. Exploring the Function of Online Narratives to Develop Critical Thinking and Localisation of Knowledge in an International Science Program

    Science.gov (United States)

    Hicks, Marianne; Tham, Melissa; Brookes, Rowan

    2017-01-01

    e-learning practitioners have long recognised the benefits of using online training to achieve knowledge transfer, less is understood about facilitating the sharing of values, attitudes, critical thinking, and localisation using online platforms. In this article an online learning platform in the context of an international scientific program was…

  3. Teachers' and Students' Perceptions of the Ideal Teacher

    NARCIS (Netherlands)

    Telli, Sibel; den Brok, Perry; Cakiroglu, Jale

    The purpose of the Study was to describe the characteristics of an ideal Turkish teacher from an interpersonal point of view. A total number of 21 teachers and 276 students (Grades 9 to 11) answered the questions "What should be/should not be the characteristics of an ideal teacher?" A total of 17

  4. On the relations between parents' ideals and children's autonomy

    NARCIS (Netherlands)

    de Ruyter, D.J.; Schinkel, A.

    2013-01-01

    In this article Doret J. de Ruyter and Anders Schinkel argue that parents' ideals can enhance children's autonomy, but that they may also have a detrimental effect on the development of children's autonomy. After describing the concept of ideals and elucidating a systems theoretical conception of

  5. The Ideal Intersection Property for Groupoid Graded Rings

    DEFF Research Database (Denmark)

    Öinert, Per Johan; Lundström, Patrik

    2012-01-01

    We show that, if a groupoid graded ring has a grading satisfying a certain nondegeneracy property, then the commutant of the center of the principal component of the ring has the ideal intersection property, that is it intersects nontrivially every nonzero ideal of the ring. Furthermore, we show...

  6. Susceptibility for thin ideal media and eating styles

    NARCIS (Netherlands)

    Anschutz, Doeschka J; Engels, Rutger C M E; van Strien, Tatjana

    This study examined the relations between susceptibility for thin ideal media and restrained, emotional and external eating, directly and indirectly through body dissatisfaction. Thin ideal media susceptibility, body dissatisfaction and eating styles were measured in a sample of 163 female students.

  7. Comparison of the perception of ideal body images of Ghanaian ...

    African Journals Online (AJOL)

    kemrilib

    that contribute to the idea of ideal body image among urban Sub-Saharan African women and in particular the influence of men on forming this ideal. In a recent survey, Ghanaian women attending the gynecology and/or radiology clinics at the Korle. Bu Teaching Hospital were interviewed regarding their perception of the ...

  8. Hellenistic imperialism and the ideal of world unity

    NARCIS (Netherlands)

    Strootman, R.

    2014-01-01

    In late antiquity and the early Middle Ages, the rulers of the Christian Romano-Byzantine Empire and Islamic Arab empires cherished the ideal of a united world under one god and one ruler. Pagan imperialist ideology profoundly influenced the evolution of this imperialist ideal of the world as a

  9. Idealization and Communication in Long-Distance Premarital Relationships.

    Science.gov (United States)

    Stafford, Laura; Reske, James R.

    1990-01-01

    Explored the phenomenon of idealization in college premarital long-distance relationships. Analyzed questionnaire responses of 71 college couples. Findings indicated long-distance couples had more restricted communication and were more idealized than their geographically close counterparts. Found an associative pattern between restricted…

  10. Evolutionary idealism: a philosophical foundation for holistic nursing theory.

    Science.gov (United States)

    Sarter, B

    1987-01-01

    The philosophical tradition of evolutionary idealism is explored as an appropriate metaphysical foundation for holistic nursing science. Some implications of this tradition for theory development, testing, and practice are identified. It is suggested that evolutionary idealism can form an appropriate philosophical foundation for nursing theory development.

  11. Moral Idealism and Social Reality: a Textual Analysis of Festus ...

    African Journals Online (AJOL)

    First Lady

    One man, Ogie Obala, returns from abroad and tries to uphold moral values and even inculcate these values in others. Can he succeed? Did he succeed? This paper demonstrates the struggle between moral idealism and social reality in Festus Iyayi‟s The Contract. Key Words: Moral, Idealism, Social Reality. Introduction.

  12. The "Body Beautiful": English Adolescents' Images of Ideal Bodies.

    Science.gov (United States)

    Dittmar, Helga; Lloyd, Barbara; Dugan, Shaun; Halliwell, Emma; Jacobs, Neil; Cramer, Helen

    2000-01-01

    Two studies examine qualities capturing adolescents' images of ideal bodies for both genders. Data from questionnaires and discussions of photographs indicate that body-image ideals are multidimensional, show systematic gender differences, and become more conventional with age. Adolescents' own body mass links systematically to body-image…

  13. Contralateral routing of signals disrupts monaural level and spectral cues to sound localisation on the horizontal plane.

    Science.gov (United States)

    Pedley, Adam J; Kitterick, Pádraig T

    2017-09-01

    Contra-lateral routing of signals (CROS) devices re-route sound between the deaf and hearing ears of unilaterally-deaf individuals. This rerouting would be expected to disrupt access to monaural level cues that can support monaural localisation in the horizontal plane. However, such a detrimental effect has not been confirmed by clinical studies of CROS use. The present study aimed to exercise strict experimental control over the availability of monaural cues to localisation in the horizontal plane and the fitting of the CROS device to assess whether signal routing can impair the ability to locate sources of sound and, if so, whether CROS selectively disrupts monaural level or spectral cues to horizontal location, or both. Unilateral deafness and CROS device use were simulated in twelve normal hearing participants. Monaural recordings of broadband white noise presented from three spatial locations (-60°, 0°, and +60°) were made in the ear canal of a model listener using a probe microphone with and without a CROS device. The recordings were presented to participants via an insert earphone placed in their right ear. The recordings were processed to disrupt either monaural level or spectral cues to horizontal sound location by roving presentation level or the energy across adjacent frequency bands, respectively. Localisation ability was assessed using a three-alternative forced-choice spatial discrimination task. Participants localised above chance levels in all conditions. Spatial discrimination accuracy was poorer when participants only had access to monaural spectral cues compared to when monaural level cues were available. CROS use impaired localisation significantly regardless of whether level or spectral cues were available. For both cues, signal re-routing had a detrimental effect on the ability to localise sounds originating from the side of the deaf ear (-60°). CROS use also impaired the ability to use level cues to localise sounds originating from

  14. Signed Total Roman Edge Domination In Graphs

    Directory of Open Access Journals (Sweden)

    Asgharsharghi Leila

    2017-11-01

    Full Text Available Let G = (V,E be a simple graph with vertex set V and edge set E. A signed total Roman edge dominating function of G is a function f : Ʃ → {−1, 1, 2} satisfying the conditions that (i Ʃe′∈N(e f(e′ ≥ 1 for each e ∈ E, where N(e is the open neighborhood of e, and (ii every edge e for which f(e = −1 is adjacent to at least one edge e′ for which f(e′ = 2. The weight of a signed total Roman edge dominating function f is !(f = Ʃe∈E f(e. The signed total Roman edge domination number y′stR(G of G is the minimum weight of a signed total Roman edge dominating function of G. In this paper, we first prove that for every tree T of order n ≥ 4, y′stR(T ≥ 17−2n/5 and we characterize all extreme trees, and then we present some sharp bounds for the signed total Roman edge domination number. We also determine this parameter for some classes of graphs.

  15. Connected domination stable graphs upon edge addition ...

    African Journals Online (AJOL)

    A set S of vertices in a graph G is a connected dominating set of G if S dominates G and the subgraph induced by S is connected. We study the graphs for which adding any edge does not change the connected domination number. Keywords: Connected domination, connected domination stable, edge addition ...

  16. Automatic Edging and Trimming of Hardwood Lumber

    Science.gov (United States)

    D. Earl Kline; Eugene M. Wengert; Philip A. Araman

    1990-01-01

    Studies have shown that there is a potential to increase hardwood lumber value by more than 20 percent through optimum edging and trimming. Even a small portion of this percentage can boost the profitability of hardwood lumber manufacturers substantially. The objective of this research project is to develop an automated system which would assist in correct edging and...

  17. Leading edge gypsy moth population dynamics

    Science.gov (United States)

    M. R. Carter; F. W. Ravlin; M. L. McManus

    1991-01-01

    Leading edge gypsy moth populations have been the focus of several intervention programs (MDIPM, AIPM). Knowledge of gypsy moth population dynamics in leading edge area is crucial for effective management. Populations in these areas tend to reach outbreak levels (noticeable defoliation) within three to four years after egg masses are first detected. Pheromone traps...

  18. An overview of JET edge modelling activities

    Energy Technology Data Exchange (ETDEWEB)

    Coster, D.P. E-mail: david.coster@ipp.mpg.de; Bonnin, X.; Corrigan, G.; Dejarnac, R.; Fenstermacher, M.; Fundamenski, W.; Geier, A.; Hogan, J.; Kallenbach, A.; Kirschner, A.; Krieger, K.; Loarte, A.; Matthews, G.; Pitts, R.A.; Porter, G.; Pugno, R.; Reiser, D.; Reiter, D.; Sipila, S.; Spence, J.; Stangeby, P.C.; Tsitrone, E.; Tskhakaya, D.; Wischmeier, M

    2003-03-01

    A number of codes are in use at JET to model the edge plasma. The range of edge codes is described as is the range of physics issues being explored by these codes. The balance between focussed modelling (that looking at particular physics effects) and integrated modelling (attempting to combine codes or encapsulate the physics from some codes into other codes) is examined.

  19. Strong List Edge Coloring of Subcubic Graphs

    Directory of Open Access Journals (Sweden)

    Hongping Ma

    2013-01-01

    Full Text Available We study strong list edge coloring of subcubic graphs, and we prove that every subcubic graph with maximum average degree less than 15/7, 27/11, 13/5, and 36/13 can be strongly list edge colored with six, seven, eight, and nine colors, respectively.

  20. LES tests on airfoil trailing edge serration

    DEFF Research Database (Denmark)

    Zhu, Wei Jun; Shen, Wen Zhong

    2016-01-01

    In the present study, a large number of acoustic simulations are carried out for a low noise airfoil with different Trailing Edge Serrations (TES). The Ffowcs Williams-Hawkings (FWH) acoustic analogy is used for noise prediction at trailing edge. The acoustic solver is running on the platform...