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Sample records for ecdysone signaling system

  1. Ecdysone signaling underlies the pea aphid transgenerational wing polyphenism.

    Science.gov (United States)

    Vellichirammal, Neetha Nanoth; Gupta, Purba; Hall, Tannice A; Brisson, Jennifer A

    2017-02-07

    The wing polyphenism of pea aphids is a compelling laboratory model with which to study the molecular mechanisms underlying phenotypic plasticity. In this polyphenism, environmental stressors such as high aphid density cause asexual, viviparous adult female aphids to alter the developmental fate of their embryos from wingless to winged morphs. This polyphenism is transgenerational, in that the pea aphid mother experiences the environmental signals, but it is her offspring that are affected. Previous research suggested that the steroid hormone ecdysone may play a role in this polyphenism. Here, we analyzed ecdysone-related gene expression patterns and found that they were consistent with a down-regulation of the ecdysone pathway being involved in the production of winged offspring. We therefore predicted that reduced ecdysone signaling would result in more winged offspring. Experimental injections of ecdysone or its analog resulted in a decreased production of winged offspring. Conversely, interfering with ecdysone signaling using an ecdysone receptor antagonist or knocking down the ecdysone receptor gene with RNAi resulted in an increased production of winged offspring. Our results are therefore consistent with the idea that ecdysone plays a causative role in the regulation of the proportion of winged offspring produced in response to crowding in this polyphenism. Our results also show that an environmentally regulated maternal hormone can mediate phenotype production in the next generation, as well as provide significant insight into the molecular mechanisms underlying the functioning of transgenerational phenotypic plasticity.

  2. Warts signaling controls organ and body growth through regulation of ecdysone

    DEFF Research Database (Denmark)

    Møller, Morten Erik; Nagy, Stanislav; Gerlach, Stephan Uwe

    2017-01-01

    Coordination of growth between individual organs and the whole body is essential during development to produce adults with appropriate size and proportions [1, 2]. How local organ-intrinsic signals and nutrient-dependent systemic factors are integrated to generate correctly proportioned organisms...... under different environmental conditions is poorly understood. In Drosophila, Hippo/Warts signaling functions intrinsically to regulate tissue growth and organ size [3, 4], whereas systemic growth is controlled via antagonistic interactions of the steroid hormone ecdysone and nutrient-dependent insulin....../insulin-like growth factor (IGF) (insulin) signaling [2, 5]. The interplay between insulin and ecdysone signaling regulates systemic growth and controls organismal size. Here, we show that Warts (Wts; LATS1/2) signaling regulates systemic growth in Drosophila by activating basal ecdysone production, which negatively...

  3. Ecdysone Control of Developmental Transitions

    DEFF Research Database (Denmark)

    Rewitz, Kim; Yamanaka, Naoki; O'Connor, Michael B.

    2013-01-01

    The steroid hormone ecdysone is the central regulator of insect developmental transitions. Recent new advances in our understanding of ecdysone action have relied heavily on the application of Drosophila melanogaster molecular genetic tools to study insect metamorphosis. In this review, we focus...... on three major aspects of Drosophila ecdysone biology: (a) factors that regulate the timing of ecdysone release, (b) molecular basis of stage- and tissue-specific responses to ecdysone, and (c) feedback regulation and coordination of ecdysone signaling....

  4. The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development

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    Bryan W. Heck

    2011-12-01

    SMRTER (SMRT-related and ecdysone receptor interacting factor is the Drosophila homologue of the vertebrate proteins SMRT and N-CoR, and forms with them a well-conserved family of transcriptional corepressors. Molecular characterization of SMRT-family proteins in cultured cells has implicated them in a wide range of transcriptional regulatory pathways. However, little is currently known about how this conserved class of transcriptional corepressors regulates the development of particular tissues via specific pathways. In this study, through our characterization of multiple Smrter (Smr mutant lines, mosaic analysis of a loss-of-function Smr allele, and studies of two independent Smr RNAi fly lines, we report that SMRTER is required for the development of both ovarian follicle cells and the wing. In these two tissues, SMRTER inhibits not only the ecdysone pathway, but also the Notch pathway. We differentiate SMRTER's influence on these two signaling pathways by showing that SMRTER inhibits the Notch pathway, but not the ecdysone pathway, in a spatiotemporally restricted manner. We further confirm the likely involvement of SMRTER in the Notch pathway by demonstrating a direct interaction between SMRTER and Suppressor of Hairless [Su(H], a DNA-binding transcription factor pivotal in the Notch pathway, and the colocalization of both proteins at many chromosomal regions in salivary glands. Based on our results, we propose that SMRTER regulates the Notch pathway through its association with Su(H, and that overcoming a SMRTER-mediated transcriptional repression barrier may represent a key mechanism used by the Notch pathway to control the precise timing of events and the formation of sharp boundaries between cells in multiple tissues during development.

  5. Ecdysone signaling regulates specification of neurons with a male-specific neurite in Drosophila

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    Binglong Zhang

    2018-02-01

    Full Text Available Some mAL neurons in the male brain form the ipsilateral neurite (ILN[+] in a manner dependent on FruBM, a male-specific transcription factor. FruBM represses robo1 transcription, allowing the ILN to form. We found that the proportion of ILN[+]-mALs in all observed single cell clones dropped from ∼90% to ∼30% by changing the heat-shock timing for clone induction from 4-5 days after egg laying (AEL to 6-7 days AEL, suggesting that the ILN[+]-mALs are produced predominantly by young neuroblasts. Upon EcR-A knockdown, ILN[+]-mALs were produced at a high rate (∼60%, even when heat shocked at 6-7 days AEL, yet EcR-B1 knockdown reduced the proportion of ILN[+]-mALs to ∼30%. Immunoprecipitation assays in S2 cells demonstrated that EcR-A and EcR-B1 form a complex with FruBM. robo1 reporter transcription was repressed by FruBM and ecdysone counteracted FruBM. We suggest that ecdysone signaling modulates the FruBM action to produce an appropriate number of male-type neurons.

  6. rigor mortis encodes a novel nuclear receptor interacting protein required for ecdysone signaling during Drosophila larval development.

    Science.gov (United States)

    Gates, Julie; Lam, Geanette; Ortiz, José A; Losson, Régine; Thummel, Carl S

    2004-01-01

    Pulses of the steroid hormone ecdysone trigger the major developmental transitions in Drosophila, including molting and puparium formation. The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer that binds to specific response elements in the genome and directly regulates target gene transcription. We describe a novel nuclear receptor interacting protein encoded by rigor mortis (rig) that is required for ecdysone responses during larval development. rig mutants display defects in molting, delayed larval development, larval lethality, duplicated mouth parts, and defects in puparium formation--phenotypes that resemble those seen in EcR, usp, E75A and betaFTZ-F1 mutants. Although the expression of these nuclear receptor genes is essentially normal in rig mutant larvae, the ecdysone-triggered switch in E74 isoform expression is defective. rig encodes a protein with multiple WD-40 repeats and an LXXLL motif, sequences that act as specific protein-protein interaction domains. Consistent with the presence of these elements and the lethal phenotypes of rig mutants, Rig protein interacts with several Drosophila nuclear receptors in GST pull-down experiments, including EcR, USP, DHR3, SVP and betaFTZ-F1. The ligand binding domain of betaFTZ-F1 is sufficient for this interaction, which can occur in an AF-2-independent manner. Antibody stains reveal that Rig protein is present in the brain and imaginal discs of second and third instar larvae, where it is restricted to the cytoplasm. In larval salivary gland and midgut cells, however, Rig shuttles between the cytoplasm and nucleus in a spatially and temporally regulated manner, at times that correlate with the major lethal phase of rig mutants and major switches in ecdysone-regulated gene expression. Taken together, these data indicate that rig exerts essential functions during larval development through gene-specific effects on ecdysone-regulated transcription, most likely as a cofactor for one or more

  7. A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain.

    Science.gov (United States)

    Ishimoto, Hiroshi; Wang, Zhe; Rao, Yi; Wu, Chun-Fang; Kitamoto, Toshihiro

    2013-01-01

    The biological actions of steroid hormones are mediated primarily by their cognate nuclear receptors, which serve as steroid-dependent transcription factors. However, steroids can also execute their functions by modulating intracellular signaling cascades rapidly and independently of transcriptional regulation. Despite the potential significance of such "non-genomic" steroid actions, their biological roles and the underlying molecular mechanisms are not well understood, particularly with regard to their effects on behavioral regulation. The major steroid hormone in the fruit fly Drosophila is 20-hydroxy-ecdysone (20E), which plays a variety of pivotal roles during development via the nuclear ecdysone receptors. Here we report that DopEcR, a G-protein coupled receptor for ecdysteroids, is involved in activity- and experience-dependent plasticity of the adult central nervous system. Remarkably, a courtship memory defect in rutabaga (Ca²⁺/calmodulin-responsive adenylate cyclase) mutants was rescued by DopEcR overexpression or acute 20E feeding, whereas a memory defect in dunce (cAMP-specific phosphodiestrase) mutants was counteracted when a loss-of-function DopEcR mutation was introduced. A memory defect caused by suppressing dopamine synthesis was also restored through enhanced DopEcR-mediated ecdysone signaling, and rescue and phenocopy experiments revealed that the mushroom body (MB)--a brain region central to learning and memory in Drosophila--is critical for the DopEcR-dependent processing of courtship memory. Consistent with this finding, acute 20E feeding induced a rapid, DopEcR-dependent increase in cAMP levels in the MB. Our multidisciplinary approach demonstrates that DopEcR mediates the non-canonical actions of 20E and rapidly modulates adult conditioned behavior through cAMP signaling, which is universally important for neural plasticity. This study provides novel insights into non-genomic actions of steroids, and opens a new avenue for genetic

  8. A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain.

    Directory of Open Access Journals (Sweden)

    Hiroshi Ishimoto

    Full Text Available The biological actions of steroid hormones are mediated primarily by their cognate nuclear receptors, which serve as steroid-dependent transcription factors. However, steroids can also execute their functions by modulating intracellular signaling cascades rapidly and independently of transcriptional regulation. Despite the potential significance of such "non-genomic" steroid actions, their biological roles and the underlying molecular mechanisms are not well understood, particularly with regard to their effects on behavioral regulation. The major steroid hormone in the fruit fly Drosophila is 20-hydroxy-ecdysone (20E, which plays a variety of pivotal roles during development via the nuclear ecdysone receptors. Here we report that DopEcR, a G-protein coupled receptor for ecdysteroids, is involved in activity- and experience-dependent plasticity of the adult central nervous system. Remarkably, a courtship memory defect in rutabaga (Ca²⁺/calmodulin-responsive adenylate cyclase mutants was rescued by DopEcR overexpression or acute 20E feeding, whereas a memory defect in dunce (cAMP-specific phosphodiestrase mutants was counteracted when a loss-of-function DopEcR mutation was introduced. A memory defect caused by suppressing dopamine synthesis was also restored through enhanced DopEcR-mediated ecdysone signaling, and rescue and phenocopy experiments revealed that the mushroom body (MB--a brain region central to learning and memory in Drosophila--is critical for the DopEcR-dependent processing of courtship memory. Consistent with this finding, acute 20E feeding induced a rapid, DopEcR-dependent increase in cAMP levels in the MB. Our multidisciplinary approach demonstrates that DopEcR mediates the non-canonical actions of 20E and rapidly modulates adult conditioned behavior through cAMP signaling, which is universally important for neural plasticity. This study provides novel insights into non-genomic actions of steroids, and opens a new avenue for

  9. Ecdysone Agonist: New Insecticides with Novel Mode of Action

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    Y. Andi Trisyono

    2002-12-01

    Full Text Available Development of insect resistance to insecticide has been the major driving force for the development of new insecticides. Awareness and demand from public for more environmentally friendly insecticides have contributed in shifting the trend from using broad spectrum to selective insecticides. As a result, scientists have looked for new target sites beyond the nervous system. Insect growth regulators (IGRs are more selective insecticides than conventional insecticides, and ecdysone agonists are the newest IGRs being commercialized, e.g. tebufenozide, methoxyfenozide, and halofenozide. Ecdysone agonists bind to the ecdysteroid receptors, and they act similarly to the molting hormone 20-hydroxyecdysone. The binding provides larvae or nymphs with a signal to enter a premature and lethal molting cycle. In addition, the ecdysone agonists cause a reduction in the number of eggs laid by female insects. The ecdysone agonists are being developed as selective biorational insecticides. Tebufenozide and methoxyfenozide are used to control lepidopteran insect pests, whereas halofenozide is being used to control coleopteran insect pests. Their selectivity is due to differences in the binding affinity between these compounds to the receptors in insects from different orders. The selectivity of these compounds makes them candidates to be used in combinations with other control strategies to develop integrated pest management programs in agricultural ecosystems. Key words: new insecticides, selectivity, ecdysone agonists

  10. Synthesis of labelled ecdysone precursors

    International Nuclear Information System (INIS)

    Haag, T.; Hetru, C.; Nakatani, Y.; Luu, B.; Meister, M.; Pichat, L.; Audinot, M.

    1985-01-01

    High specific activity tritiated 3β,14α-dihydroxy-5β-cholest-7-en-6-one, has been prepared using a precursor which permits rapid and easy labelling. This compound is converted to ecdysone under in vitro conditions by insect prothoracic glands, a well known site of ecdysone biosynthesis. (author)

  11. Towards Coleoptera-specific high-throughput screening systems for compounds with ecdysone activity: development of EcR reporter assays using weevil (Anthonomus grandis)-derived cell lines and in silico analysis of ligand binding to A. grandis EcR ligand-binding pocket.

    Science.gov (United States)

    Soin, Thomas; Iga, Masatoshi; Swevers, Luc; Rougé, Pierre; Janssen, Colin R; Smagghe, Guy

    2009-08-01

    Molting in insects is regulated by ecdysteroids and juvenile hormones. Several synthetic non-steroidal ecdysone agonists are on the market as insecticides. These ecdysone agonists are dibenzoylhydrazine (DBH) analogue compounds that manifest their toxicity via interaction with the ecdysone receptor (EcR). Of the four commercial available ecdysone agonists, three (tebufenozide, methoxyfenozide and chromafenozide) are highly lepidopteran specific, one (halofenozide) is used to control coleopteran and lepidopteran insects in turf and ornamentals. However, compared to the very high binding affinity of these DBH analogues to lepidopteran EcRs, halofenozide has a low binding affinity for coleopteran EcRs. For the discovery of ecdysone agonists that target non-lepidopteran insect groups, efficient screening systems that are based on the activation of the EcR are needed. We report here the development and evaluation of two coleopteran-specific reporter-based screening systems to discover and evaluate ecdysone agonists. The screening systems are based on the cell lines BRL-AG-3A and BRL-AG-3C that are derived from the weevil Anthonomus grandis, which can be efficiently transduced with an EcR reporter cassette for evaluation of induction of reporter activity by ecdysone agonists. We also cloned the almost full length coding sequence of EcR expressed in the cell line BRL-AG-3C and used it to make an initial in silico 3D-model of its ligand-binding pocket docked with ponasterone A and tebufenozide.

  12. The Mechanisms of the Ecdysone Pulses that Cause Metamorphosis

    DEFF Research Database (Denmark)

    Møller, Morten Erik

    Maturation in both mammals and insects is caused by pulses of steroid hormones released from glands in response to a brain-derived signal. The timing of this developmental transition is secured by the integration of many developmental cues, such as size, external environment and nutritional...... of ecdysone biosynthesis, necessary for the generation of the temporally defined pulse prior to the metamorphosis. We found that ecdysone works back on the PG itself through its receptor, EcR, to regulate the expression of the transcription factor broad isoform Z4 (br-Z4), which in turn regulates...

  13. Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascades.

    Directory of Open Access Journals (Sweden)

    Robert J Ihry

    Full Text Available Steroid hormones act, through their respective nuclear receptors, to regulate target gene expression. Despite their critical role in development, physiology, and disease, however, it is still unclear how these systemic cues are refined into tissue-specific responses. We identified a mutation in the evolutionarily conserved DEAD box RNA helicase belle/DDX3 that disrupts a subset of responses to the steroid hormone ecdysone during Drosophila melanogaster metamorphosis. We demonstrate that belle directly regulates translation of E74A, an ets transcription factor and critical component of the ecdysone-induced transcriptional cascade. Although E74A mRNA accumulates to abnormally high levels in belle mutant tissues, no E74A protein is detectable, resulting in misregulation of E74A-dependent ecdysone response genes. The accumulation of E74A mRNA in belle mutant salivary glands is a result of auto-regulation, fulfilling a prediction made by Ashburner nearly 40 years ago. In this model, Ashburner postulates that, in addition to regulating secondary response genes, protein products of primary response genes like E74A also inhibit their own ecdysone-induced transcription. Moreover, although ecdysone-triggered transcription of E74A appears to be ubiquitous during metamorphosis, belle-dependent translation of E74A mRNA is spatially restricted. These results demonstrate that translational control plays a critical, and previously unknown, role in refining transcriptional responses to the steroid hormone ecdysone.

  14. Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis.

    Science.gov (United States)

    Ohhara, Yuya; Shimada-Niwa, Yuko; Niwa, Ryusuke; Kayashima, Yasunari; Hayashi, Yoshiki; Akagi, Kazutaka; Ueda, Hitoshi; Yamakawa-Kobayashi, Kimiko; Kobayashi, Satoru

    2015-02-03

    In Drosophila, pulsed production of the steroid hormone ecdysone plays a pivotal role in developmental transitions such as metamorphosis. Ecdysone production is regulated in the prothoracic gland (PG) by prothoracicotropic hormone (PTTH) and insulin-like peptides (Ilps). Here, we show that monoaminergic autocrine regulation of ecdysone biosynthesis in the PG is essential for metamorphosis. PG-specific knockdown of a monoamine G protein-coupled receptor, β3-octopamine receptor (Octβ3R), resulted in arrested metamorphosis due to lack of ecdysone. Knockdown of tyramine biosynthesis genes expressed in the PG caused similar defects in ecdysone production and metamorphosis. Moreover, PTTH and Ilps signaling were impaired by Octβ3R knockdown in the PG, and activation of these signaling pathways rescued the defect in metamorphosis. Thus, monoaminergic autocrine signaling in the PG regulates ecdysone biogenesis in a coordinated fashion on activation by PTTH and Ilps. We propose that monoaminergic autocrine signaling acts downstream of a body size checkpoint that allows metamorphosis to occur when nutrients are sufficiently abundant.

  15. Early gene Broad complex plays a key role in regulating the immune response triggered by ecdysone in the Malpighian tubules of Drosophila melanogaster.

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    Verma, Puja; Tapadia, Madhu G

    2015-08-01

    In insects, humoral response to injury is accomplished by the production of antimicrobial peptides (AMPs) which are secreted in the hemolymph to eliminate the pathogen. Drosophila Malpighian tubules (MTs), however, are unique immune organs that show constitutive expression of AMPs even in unchallenged conditions and the onset of immune response is developmental stage dependent. Earlier reports have shown ecdysone positively regulates immune response after pathogenic challenge however, a robust response requires prior potentiation by the hormone. Here we provide evidence to show that MTs do not require prior potentiation with ecdysone hormone for expression of AMPs and they respond to ecdysone very fast even without immune challenge, although the different AMPs Diptericin, Cecropin, Attacin, Drosocin show differential expression in response to ecdysone. We show that early gene Broad complex (BR-C) could be regulating the IMD pathway by activating Relish and physically interacting with it to activate AMPs expression. BR-C depletion from Malpighian tubules renders the flies susceptible to infection. We also show that in MTs ecdysone signaling is transduced by EcR-B1 and B2. In the absence of ecdysone signaling the IMD pathway associated genes are down regulated and activation and translocation of transcription factor Relish is also affected. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor

    International Nuclear Information System (INIS)

    Kimura, Shuhei; Sawatsubashi, Shun; Ito, Saya; Kouzmenko, Alexander; Suzuki, Eriko; Zhao, Yue; Yamagata, Kaoru; Tanabe, Masahiko; Ueda, Takashi; Fujiyama, Sari; Murata, Takuya; Matsukawa, Hiroyuki; Takeyama, Ken-ichi; Yaegashi, Nobuo

    2008-01-01

    Histone arginine methylation is an epigenetic marker that regulates gene expression by defining the chromatin state. Arginine methyltransferases, therefore, serve as transcriptional co-regulators. However, unlike other transcriptional co-regulators, the physiological roles of arginine methyltransferases are poorly understood. Drosophila arginine methyltransferase 1 (DART1), the mammalian PRMT1 homologue, methylates the arginine residue of histone H4 (H4R3me2). Disruption of DART1 in Drosophila by imprecise P-element excision resulted in low viability during metamorphosis in the pupal stages. In the pupal stage, an ecdysone hormone signal is critical for developmental progression. DART1 interacted with the nuclear ecdysone receptor (EcR) in a ligand-dependent manner, and co-repressed EcR in intact flies. These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly

  17. Biomedical signals and systems

    CERN Document Server

    Tranquillo, Joseph V

    2013-01-01

    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

  18. Bioelectric Signal Measuring System

    Science.gov (United States)

    Guadarrama-Santana, A.; Pólo-Parada, L.; García-Valenzuela, A.

    2015-01-01

    We describe a low noise measuring system based on interdigitated electrodes for sensing bioelectrical signals. The system registers differential voltage measurements in order of microvolts. The base noise during measurements was in nanovolts and thus, the sensing signals presented a very good signal to noise ratio. An excitation voltage of 1Vrms with 10 KHz frequency was applied to an interdigitated capacitive sensor without a material under test and to a mirror device simultaneously. The output signals of both devices was then subtracted in order to obtain an initial reference value near cero volts and reduce parasitic capacitances due to the electronics, wiring and system hardware as well. The response of the measuring system was characterized by monitoring temporal bioelectrical signals in real time of biological materials such as embryo chicken heart cells and bovine suprarenal gland cells.

  19. Signals and systems

    CERN Document Server

    Rao, K Deergha

    2018-01-01

    This textbook covers the fundamental theories of signals and systems analysis, while incorporating recent developments from integrated circuits technology into its examples. Starting with basic definitions in signal theory, the text explains the properties of continuous-time and discrete-time systems and their representation by differential equations and state space. From those tools, explanations for the processes of Fourier analysis, the Laplace transform, and the z-Transform provide new ways of experimenting with different kinds of time systems. The text also covers the separate classes of analog filters and their uses in signal processing applications. Intended for undergraduate electrical engineering students, chapter sections include exercise for review and practice for the systems concepts of each chapter. Along with exercises, the text includes MATLAB-based examples to allow readers to experiment with signals and systems code on their own. An online repository of the MATLAB code from this textbook can...

  20. Radiation signal processing system

    International Nuclear Information System (INIS)

    Bennett, M.; Knoll, G.; Strange, D.

    1980-01-01

    An improved signal processing system for radiation imaging apparatus comprises: a radiation transducer producing transducer signals proportional to apparent spatial coordinates of detected radiation events; means for storing true spatial coordinates corresponding to a plurality of predetermined apparent spatial coordinates relative to selected detected radiation events said means for storing responsive to said transducer signal and producing an output signal representative of said true spatial coordinates; and means for interpolating the true spatial coordinates of the detected radiation events located intermediate the stored true spatial coordinates, said means for interpolating communicating with said means for storing

  1. Signals and systems for dummies

    CERN Document Server

    Wickert, Mark

    2013-01-01

    Getting mixed signals in your signals and systems course? The concepts covered in a typical signals and systems course are often considered by engineering students to be some of the most difficult to master. Thankfully, Signals & Systems For Dummies is your intuitive guide to this tricky course, walking you step-by-step through some of the more complex theories and mathematical formulas in a way that is easy to understand. From Laplace Transforms to Fourier Analyses, Signals & Systems For Dummies explains in plain English the difficult concepts that can trip you up

  2. Wireless data signal transmission system

    DEFF Research Database (Denmark)

    2014-01-01

    The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver.......The present invention relates to a method for providing a radio frequency signal for transmission, a system for providing a radio frequency signal for transmission and a method for wireless data transmission between a transmitter and a receiver....

  3. Acoustic Signals and Systems

    DEFF Research Database (Denmark)

    2008-01-01

    The Handbook of Signal Processing in Acoustics will compile the techniques and applications of signal processing as they are used in the many varied areas of Acoustics. The Handbook will emphasize the interdisciplinary nature of signal processing in acoustics. Each Section of the Handbook...... will present topics on signal processing which are important in a specific area of acoustics. These will be of interest to specialists in these areas because they will be presented from their technical perspective, rather than a generic engineering approach to signal processing. Non-specialists, or specialists...... from different areas, will find the self-contained chapters accessible and will be interested in the similarities and differences between the approaches and techniques used in different areas of acoustics....

  4. Ecdysone Induction of MsrA Protects Against Oxidative Stress in Drosophila

    Energy Technology Data Exchange (ETDEWEB)

    Roesijadi, Guri; Rezvankhah, Saeid; Binninger, David M.; Weissbach, Herbert

    2007-03-09

    The methionine sulfoxide reductases MsrA and MsrB reduce Met(O) to Met in epimer-specific fashion. In Drosophila, the major ecdysone induced protein is MsrA, which is regulated by the EcR-USP complex. We tested Kc cells for induction of MsrA, MsrB, EcR. and CAT by ecdysone and found that MsrA and the EcR were induced by ecdysone, but MsrB and CAT were not. When we tested for resistance to 20 mM H2O2 toxicity, viability of Kc cells was reduced threefold. After pretreatment with 0.2 μM ecdysone for 48 h, then exposed to H2O2, viability of Kc cells increased to 77% of controls. The EcR-deficient L57-3-11 knockout line was not responsive to ecdysone, and H2O2 resistance of both control and ecdysone-treated L57-3-11 cells was similar to that of the ecdysone-untreated Kc cells. These results show that hormonal regulation of MsrA is implicated in conferring protection against oxidative stress in the Drosophila model.

  5. Trypanosoma cruzi: effects of azadirachtin and ecdysone on the dynamic development in Rhodnius prolixus larvae.

    Science.gov (United States)

    Cortez, M R; Provençano, A; Silva, C E; Mello, C B; Zimmermann, L T; Schaub, G A; Garcia, E S; Azambuja, P; Gonzalez, M S

    2012-07-01

    The effects of azadirachtin and ecdysone on the Trypanosoma cruzi population in the Rhodnius prolixus gut were investigated. T. cruzi were rarely found in the gut compartments of azadirachtin-treated larvae. High parasite numbers were observed in the stomach of the control and ecdysone groups until 10 days after treatment and in the small intestine and rectum until 25 days after treatment. High percentages of round forms developed in the stomachs of all groups, whereas azadirachtin blocked the development of protozoan intermediate forms. This effect was counteracted by ecdysone therapy. In the small intestine and rectum, epimastigotes predominated for all groups, but more of their intermediates developed in the control and ecdysone groups. Azadirachtin supported the development of round forms and their intermediates into trypomastigotes. In the rectum, trypomastigotes did not develop in the azadirachtin group and developed much later after ecdysone therapy. The parallel between the effects of azadirachtin and ecdysone on the host and parasite development is discussed on the basis of the present results because ecdysone appears to act directly or indirectly in determining the synchronic development of T. cruzi forms from round to epimastigotes, but not metacyclic trypomastigotes, in the invertebrate vector. Copyright © 2012 Elsevier Inc. All rights reserved.

  6. Signals and systems with MATLAB

    CERN Document Server

    Yang, Won Young; Song, Ik H; Cho, Yong S

    2009-01-01

    Covers some of the theoretical foundations and mathematical derivations that can be used in higher-level related subjects such as signal processing, communication, and control, minimizing the mathematical difficulty and computational burden. This book illustrates the usage of MATLAB and Simulink for signal and system analysis and design.

  7. Ecdysone-dependent and ecdysone-independent programmed cell death in the developing optic lobe of Drosophila.

    Science.gov (United States)

    Hara, Yusuke; Hirai, Keiichiro; Togane, Yu; Akagawa, Hiromi; Iwabuchi, Kikuo; Tsujimura, Hidenobu

    2013-02-01

    The adult optic lobe of Drosophila develops from the primordium during metamorphosis from mid-3rd larval stage to adult. Many cells die during development of the optic lobe with a peak of the number of dying cells at 24 h after puparium formation (h APF). Dying cells were observed in spatio-temporal specific clusters. Here, we analyzed the function of a component of the insect steroid hormone receptor, EcR, in this cell death. We examined expression patterns of two EcR isoforms, EcR-A and EcR-B1, in the optic lobe. Expression of each isoform altered during development in isoform-specific manner. EcR-B1 was not expressed in optic lobe neurons from 0 to 6h APF, but was expressed between 9 and 48 h APF and then disappeared by 60 h APF. In each cortex, its expression was stronger in older glia-ensheathed neurons than in younger ones. EcR-B1 was also expressed in some types of glia. EcR-A was expressed in optic lobe neurons and many types of glia from 0 to 60 h APF in a different pattern from EcR-B1. Then, we genetically analyzed EcR function in the optic lobe cell death. At 0 h APF, the optic lobe cell death was independent of any EcR isoforms. In contrast, EcR-B1 was required for most optic lobe cell death after 24 h APF. It was suggested that cell death cell-autonomously required EcR-B1 expressed after puparium formation. βFTZ-F1 was also involved in cell death in many dying-cell clusters, but not in some of them at 24 h APF. Altogether, the optic lobe cell death occurred in ecdysone-independent manner at prepupal stage and ecdysone-dependent manner after 24 h APF. The acquisition of ecdysone-dependence was not directly correlated with the initiation or increase of EcR-B1 expression. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. Signal system data mining

    Science.gov (United States)

    2000-09-01

    Intelligent transportation systems (ITS) include large numbers of traffic sensors that collect enormous quantities of data. The data provided by ITS is necessary for advanced forms of control, however basic forms of control, primarily time-of-day (TO...

  9. Spook and Spookier code for stage-specific components of the ecdysone biosynthetic pathway in Diptera

    DEFF Research Database (Denmark)

    Ono, Hajime; Rewitz, Kim; Shinoda, Tetsu

    2006-01-01

    is eliminated in larvae carrying mutations in molting defective (mld), a gene encoding a nuclear zinc finger protein that is required for production of ecdysone during Drosophila larval development. Intriguingly, mld is not present in the Bombyx mori genome, and we have identified only one spook homolog in both...... Bombyx and Manduca that is expressed in both embryos and larva. These studies suggest an evolutionary split between Diptera and Lepidoptera in how the ecdysone biosynthetic pathway is regulated during development....

  10. Handbook of signal processing systems

    CERN Document Server

    Deprettere, Ed; Leupers, Rainer; Takala, Jarmo

    2013-01-01

    Handbook of Signal Processing Systems is organized in three parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools, describes models of computation and their associated design tools and methodologies. This handbook is an essential tool for professionals in many fields and researchers of all levels.

  11. Ecdysone Receptor-based Singular Gene Switches for Regulated Transgene Expression in Cells and Adult Rodent Tissues

    Directory of Open Access Journals (Sweden)

    Seoghyun Lee

    2016-01-01

    Full Text Available Controlled gene expression is an indispensable technique in biomedical research. Here, we report a convenient, straightforward, and reliable way to induce expression of a gene of interest with negligible background expression compared to the most widely used tetracycline (Tet-regulated system. Exploiting a Drosophila ecdysone receptor (EcR-based gene regulatory system, we generated nonviral and adenoviral singular vectors designated as pEUI(+ and pENTR-EUI, respectively, which contain all the required elements to guarantee regulated transgene expression (GAL4-miniVP16-EcR, termed GvEcR hereafter, and 10 tandem repeats of an upstream activation sequence promoter followed by a multiple cloning site. Through the transient and stable transfection of mammalian cell lines with reporter genes, we validated that tebufenozide, an ecdysone agonist, reversibly induced gene expression, in a dose- and time-dependent manner, with negligible background expression. In addition, we created an adenovirus derived from the pENTR-EUI vector that readily infected not only cultured cells but also rodent tissues and was sensitive to tebufenozide treatment for regulated transgene expression. These results suggest that EcR-based singular gene regulatory switches would be convenient tools for the induction of gene expression in cells and tissues in a tightly controlled fashion.

  12. Ariadne merione ecdysone receptor (AmEcR protein: An in silico approach for comparison of agonist and antagonist compounds

    Directory of Open Access Journals (Sweden)

    Chandran Sundaravadivelan

    2017-12-01

    Full Text Available Ecdysteroid signal transduction plays a major role in insect metamorphosis, 20-hydroxyecdysone (20E binds to the nuclear receptor composed of the ecdysone receptor ligand binding domine (EcR-LBD and triggers the developmental transitions. Ariadne merione ecdysone receptor (AmEcR cDNA was amplified and partially sequenced of about 553 bp, which encodes a polypeptide of 184 amino acids (aa. The theoretical molecular weight (MW, isoelectric point (pI and aliphatic index of the deduced AmEcR protein were predicted using BIOEDIT (v7.2.5 to be 21.192 kDa, 9.31 and 101.739 respectively. Identified ecdysone receptor gene of A. merione showed maximum similarity with Precis coenia gene. In this research, we have employed ligand-receptor engineering technique to screen a specific compound which plays antagonist role and assist to formulate an insect specific pesticide. The EcR protein 3D structure of AmEcR modeled using Schrödinger maestro and virtual screening was performed using 5554 molecules from Zinc database, where ZINC20031812 showed highest glide score of −6.257 and Etoxazole chosen on literature basis and showed best glide score −6.671. We have compared the antagonist with agonist (20E by molecular dynamics (MD simulation. Root Mean Square Deviation (RMSD value of agonist and antagonist indicates the binding were stable in water with a range of distance from 2.3 to 2.6 Å, 1.8 to 2.3 Å and 1.9 to 2.3 Å with a variation over the time scale of 1 ps. Since Etoxazole and ZINC20031812 are antagonists, computationally they were more stable than 20E. Keywords: Ariadne merione, 20 Hydroxyecdysone (20E, Etoxazole, Schrödinger

  13. Insulin and 20-hydroxyecdysone action in Bombyx mori: Glycogen content and expression pattern of insulin and ecdysone receptors in fat body.

    Science.gov (United States)

    Keshan, Bela; Thounaojam, Bembem; Kh, Sanathoibi D

    2017-01-15

    Insulin and ecdysone signaling play a critical role on the growth and development of insects including Bombyx mori. Our previous study showed that Bombyx larvae reached critical weight for metamorphosis between day 3.5 and 4 of the fifth larval instar. The present study showed that the effect of insulin on the accumulation of glycogen in fat body of Bombyx larvae depends on the critical growth period. When larvae are in active growth period (before reaching critical weight), insulin caused increased accumulation of glycogen, while its treatment in larvae at terminal growth period (after critical period) resulted in an increased mobilization of glycogen. During terminal growth period, insulin and 20-hydroxyecdysone (20E) showed an antagonistic effect on the accumulation of fat body glycogen in fed, food deprived and decapitated larvae as well as in isolated abdomens. Insulin treatment decreased the glycogen content, whereas, 20E increased it. Food deprivation and decapitation caused an increase in the transcript levels of insulin receptor (InR) and this increase in InR expression might be attributed to a decrease in synthesis/secretion of insulin-like peptides, as insulin treatment in these larvae showed a down-regulation in InR expression. However, insulin showed an up-regulation in InR in isolated abdomens and it suggests that in food deprived and decapitated larvae, the exogenous insulin may interact with some head and/or thoracic factors in modulating the expression of InR. Moreover, in fed larvae, insulin-mediated increase in InR expression indicates that its regulation by insulin-like peptides also depends on the nutritional status of the larvae. The treatment of 20E in fed larvae showed an antagonistic effect on the transcript levels since a down-regulation in InR expression was observed. 20E treatment also led to a decreased expression of InR in food deprived and decapitated larvae as well as in isolated abdomens. Insulin and 20E also modulated the

  14. Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2.

    Directory of Open Access Journals (Sweden)

    Sebastien A Gauthier

    Full Text Available The ecdysone receptor is a heterodimer of two nuclear receptors, the Ecdysone receptor (EcR and Ultraspiracle (USP. In Drosophila melanogaster, three EcR isoforms share common DNA and ligand-binding domains, but these proteins differ in their most N-terminal regions and, consequently, in the activation domains (AF1s contained therein. The transcriptional coactivators for these domains, which impart unique transcriptional regulatory properties to the EcR isoforms, are unknown. Activating transcription factor 4 (ATF4 is a basic-leucine zipper transcription factor that plays a central role in the stress response of mammals. Here we show that Cryptocephal (CRC, the Drosophila homolog of ATF4, is an ecdysone receptor coactivator that is specific for isoform B2. CRC interacts with EcR-B2 to promote ecdysone-dependent expression of ecdysis-triggering hormone (ETH, an essential regulator of insect molting behavior. We propose that this interaction explains some of the differences in transcriptional properties that are displayed by the EcR isoforms, and similar interactions may underlie the differential activities of other nuclear receptors with distinct AF1-coactivators.

  15. Induction of the early-late Ddc gene during Drosophila metamorphosis by the ecdysone receptor.

    Science.gov (United States)

    Chen, Li; Reece, Christian; O'Keefe, Sandra L; Hawryluk, Gregory W L; Engstrom, Monica M; Hodgetts, Ross B

    2002-06-01

    During Drosophila metamorphosis, the 'early-late' genes constitute a unique class regulated by the steroid hormone 20-hydroxyecdysone. Their induction is comprised of both a primary and a secondary response to ecdysone. Previous work has suggested that the epidermal expression of the dopa decarboxylase gene (Ddc) is likely that of a typical early-late gene. Accumulation of the Ddc transcript is rapidly initiated in the absence of protein synthesis, which implies that the ecdysone receptor plays a direct role in induction. However, full Ddc expression requires the participation of one of the transcription factors encoded by the Broad-Complex. In this paper, we characterize an ecdysone response element (EcRE) that contributes to the primary response. Using gel mobility shift assays and transgenic assays, we identified a single functional EcRE, located at position -97 to -83 bp relative to the transcription initiation site. This is the first report of an EcRE associated with an early-late gene in Drosophila. Competition experiments indicated that the affinity of the Ddc EcRE for the ecdysone receptor complex was at least four-fold less than that of the canonical EcRE of the hsp27 gene. Using in vitro mutagenesis, we determined that the reduced affinity of the EcRE resided at two positions where the nucleotides differed from those found in the canonical sequence. The ecdysone receptor, acting through this EcRE, releases Ddc from a silencing mechanism, whose cis-acting domain we have mapped to the 5'-upstream region between -2067 and -1427 bp. Deletion of this repressive element resulted in precocious expression of Ddc in both epidermis and imaginal discs. Thus, epidermal Ddc induction at pupariation is under the control of an extended genomic region that contains both positive and negative regulatory elements. Copyright 2002 Elsevier Science Ireland Ltd.

  16. Effects of Quinizarin and Five Synthesized Derivatives on Fifth Larval Instar Midgut Ecdysone 20-Monooxygenase Activity of the Tobacco Hornworm Manduca sexta

    Directory of Open Access Journals (Sweden)

    Christopher A. Drummond

    2014-01-01

    Full Text Available The plant allelochemical, quinizarin (1,4-dihydroxy-9,10-anthraquinone, and five anthraquinones that were synthesized from quinizarin, namely, 1,4-anthraquinone; 2-hydroxy-1,4-anthraquinone; 2-methoxy-1,4-anthraquinone; 9-hydroxy-1,4-anthraquinone; and 9-methoxy-1,4-anthraquinone, were assessed as to their effects on the essential, P450-dependent ecdysone 20-monooxygenase system of the insect model Manduca sexta (tobacco hornworm. This steroid hydroxylase converts the arthropod molting hormone, ecdysone, to the physiologically required 20-hydroxyecdysone form. M. sexta fifth larval instar midgut homogenates were incubated with increasing concentrations (10−8 to 10−3 M of each of the six anthraquinones followed by ecdysone 20-monooxygenase assessments using a radioenzymological assay. Four of the five anthraquinones exhibited I50’s of about 4×10-6 to 6×10-2 M. The most effective inhibitors were 2-methoxy-1,4-anthraquinone and 1,4-anthraquinone followed by 9-hydroxy-1,4 anthraquinone and 9-methoxy-1,4-anthraquinone. At lower concentrations the latter anthraquinone stimulated E20M activity. Quinizarin was less inhibitory and 2-hydroxy-1,4-anthraquinone was essentially without effect. Significantly, these studies make evident for the first time that anthraquinones can affect insect E20M activity, and thus insect endocrine regulation and development, and that a relationship between anthraquinone structure and effectiveness is apparent. These studies represent the first demonstrations of anthraquinones affecting any steroid hydroxylase system.

  17. Effects of irradiation of Bombyx mori larvae on the evolution of ecdysteroid titer in haemolymph and ecdysone metabolism

    International Nuclear Information System (INIS)

    Coulon, Madeleine; Feyereisen, Rene

    1977-01-01

    Second and third instar larvae of B. mori show a peak of ecdysteroids in the haemolymph towards the end of each instar. Second instar larvae which are X-ray treated at 0 h die at the third ecdysis. In these larvae, titer and metabolism of ecdysone is disturbed. Larvae X-ray treated at 24h in the second instar mostly become permanent larvae of the third instar, having a very low level of circulating ecdysteroids, which hardly metabolize injected ecdysone [fr

  18. Signals and systems primer with Matlab

    CERN Document Server

    Poularikas, Alexander D

    2006-01-01

    Signals and Systems Primer with MATLAB® equally emphasizes the fundamentals of both analog and digital signals and systems. To ensure insight into the basic concepts and methods, the text presents a variety of examples that illustrate a wide range of applications, from microelectromechanical to worldwide communication systems. It also provides MATLAB functions and procedures for practice and verification of these concepts.Taking a pedagogical approach, the author builds a solid foundation in signal processing as well as analog and digital systems. The book first introduces orthogonal signals,

  19. Signals, systems, transforms, and digital signal processing with Matlab

    CERN Document Server

    Corinthios, Michael

    2009-01-01

    Continuous-Time and Discrete-Time Signals and SystemsIntroductionContinuous-Time SignalsPeriodic FunctionsUnit Step FunctionGraphical Representation of FunctionsEven and Odd Parts of a FunctionDirac-Delta ImpulseBasic Properties of the Dirac-Delta ImpulseOther Important Properties of the ImpulseContinuous-Time SystemsCausality, StabilityExamples of Electrical Continuous-Time SystemsMechanical SystemsTransfer Function and Frequency ResponseConvolution and CorrelationA Right-Sided and a Left-Sided FunctionConvolution with an Impulse and Its DerivativesAdditional Convolution PropertiesCorrelation FunctionProperties of the Correlation FunctionGraphical InterpretationCorrelation of Periodic FunctionsAverage, Energy and Power of Continuous-Time SignalsDiscrete-Time SignalsPeriodicityDifference EquationsEven/Odd DecompositionAverage Value, Energy and Power SequencesCausality, StabilityProblemsAnswers to Selected ProblemsFourier Series ExpansionTrigonometric Fourier SeriesExponential Fourier SeriesExponential versus ...

  20. Signal-regulated systems and networks

    CSIR Research Space (South Africa)

    Van Zyl, TL

    2010-07-01

    Full Text Available The article presents the use of signal regulatory networks (SRNs), a biologically inspired model based on gene regulatory networks. SRNs are a way of understanding a class of self-organizing IT systems, signal-regulated systems (SRSs). This article...

  1. The IRS-1 signaling system.

    Science.gov (United States)

    Myers, M G; Sun, X J; White, M F

    1994-07-01

    Insulin-receptor substrate 1 (IRS-1) is a principal substrate of the receptor tyrosine kinase for insulin and insulin-like growth factor 1, and a substrate for a tyrosine kinase activated by interleukin 4. IRS-1 undergoes multisite tyrosine phosphorylation and mediates downstream signals by 'docking' various proteins that contain Src homology 2 domains. IRS-1 appears to be a unique molecule; however, 4PS, a protein found mainly in hemopoietic cells, may represent another member of this family.

  2. Signals and systems laboratory with Matlab

    CERN Document Server

    Palamides, Alex

    2010-01-01

    Introduction to MATLAB®Working EnvironmentGetting StartedMemory ManagementVectorsMatricesPlotting with MATLABComplex NumbersM-FilesInput-Output CommandsFile ManagementLogical-Relational OperatorsControl FlowSymbolic VariablesPolynomials(Pseudo)Random NumbersSignalsCategorization by the Variable TypeBasic Continuous-Time SignalsDiscrete-Time SignalsProperties of SignalsTransformations of the Time Variable for Continuous-Time SignalsTransformations of the Time Variable for Discrete-Time SignalsSystemsSystems ClassificationProperties of SystemsTime Domain System AnalysisImpulse ResponseContinuous Time Convolution Convolution PropertiesInterconnections of SystemsStabilityDiscrete-Time ConvolutionSystems Described by Difference EquationsFiltersStability Criterion for Discrete-Time SystemsSystems Described by Differential EquationsStep Response of a SystemFourier SeriesOrthogonality of Complex Exponential SignalsComplex Exponential Fourier SeriesTrigonometric Fourier SeriesFourier Series in the Cosine with Phase F...

  3. Electrical Signaling, Photosynthesis and Systemic Acquired Acclimation

    Directory of Open Access Journals (Sweden)

    Magdalena Szechyńska-Hebda

    2017-09-01

    Full Text Available Electrical signaling in higher plants is required for the appropriate intracellular and intercellular communication, stress responses, growth and development. In this review, we have focus on recent findings regarding the electrical signaling, as a major regulator of the systemic acquired acclimation (SAA and the systemic acquired resistance (SAR. The electric signaling on its own cannot confer the required specificity of information to trigger SAA and SAR, therefore, we have also discussed a number of other mechanisms and signaling systems that can operate in combination with electric signaling. We have emphasized the interrelation between ionic mechanism of electrical activity and regulation of photosynthesis, which is intrinsic to a proper induction of SAA and SAR. In a special way, we have summarized the role of non-photochemical quenching and its regulator PsbS. Further, redox status of the cell, calcium and hydraulic waves, hormonal circuits and stomatal aperture regulation have been considered as components of the signaling. Finally, a model of light-dependent mechanisms of electrical signaling propagation has been presented together with the systemic regulation of light-responsive genes encoding both, ion channels and proteins involved in regulation of their activity. Due to space limitations, we have not addressed many other important aspects of hormonal and ROS signaling, which were presented in a number of recent excellent reviews.

  4. Signalling pathways involved in adult heart formation revealed by gene expression profiling in Drosophila.

    Directory of Open Access Journals (Sweden)

    Bruno Zeitouni

    2007-10-01

    Full Text Available Drosophila provides a powerful system for defining the complex genetic programs that drive organogenesis. Under control of the steroid hormone ecdysone, the adult heart in Drosophila forms during metamorphosis by a remodelling of the larval cardiac organ. Here, we evaluated the extent to which transcriptional signatures revealed by genomic approaches can provide new insights into the molecular pathways that underlie heart organogenesis. Whole-genome expression profiling at eight successive time-points covering adult heart formation revealed a highly dynamic temporal map of gene expression through 13 transcript clusters with distinct expression kinetics. A functional atlas of the transcriptome profile strikingly points to the genomic transcriptional response of the ecdysone cascade, and a sharp regulation of key components belonging to a few evolutionarily conserved signalling pathways. A reverse genetic analysis provided evidence that these specific signalling pathways are involved in discrete steps of adult heart formation. In particular, the Wnt signalling pathway is shown to participate in inflow tract and cardiomyocyte differentiation, while activation of the PDGF-VEGF pathway is required for cardiac valve formation. Thus, a detailed temporal map of gene expression can reveal signalling pathways responsible for specific developmental programs and provides here substantial grasp into heart formation.

  5. Cyclic LTI Systems in Digital Signal Processing

    National Research Council Canada - National Science Library

    Vaidyanathan, P

    1998-01-01

    .... While circular convolution has been the centerpiece of many algorithms in signal processing for decades, such freedom, especially from the viewpoint of linear system theory, has not been studied in the past...

  6. Ultrastructure of cuticle deposited inPlodia interpunctella wing discs after variousβ-ecdysone treatments in vitro.

    Science.gov (United States)

    Dutkowski, A B; Oberlander, H; Leach, C E

    1977-06-01

    Wing discs of the Indian meal moth may be cultured for extended periods in vitro. The discs produced a tanned cuticle after continuous incubation with β-ecdysone in medium conditioned with fat body or after a 24-h pulse incubation with β-ecdysone in plain medium. We investigated the ultrastructure of the cuticle deposited by such discs. We found that the treatment that produced the most complete cuticle in vitro was the 24-h pulse of hormone. We observed that cuticle formation in vitro was not "all-or-none." Depending on culture conditions, discs produced cuticulin only, complete epicuticle, epicuticle plus diffuse endocuticle, epicuticle plus lamellate endocuticle, or even multiple layers of cuticle. The ultrastructural evidence suggests that continuous incubation with β-ecdysone in plain medium does not always inhibit cuticle formationper se, but does prevent tanning of the partially formed cuticle.

  7. Signals and transforms in linear systems analysis

    CERN Document Server

    Wasylkiwskyj, Wasyl

    2013-01-01

    Signals and Transforms in Linear Systems Analysis covers the subject of signals and transforms, particularly in the context of linear systems theory. Chapter 2 provides the theoretical background for the remainder of the text. Chapter 3 treats Fourier series and integrals. Particular attention is paid to convergence properties at step discontinuities. This includes the Gibbs phenomenon and its amelioration via the Fejer summation techniques. Special topics include modulation and analytic signal representation, Fourier transforms and analytic function theory, time-frequency analysis and frequency dispersion. Fundamentals of linear system theory for LTI analogue systems, with a brief account of time-varying systems, are covered in Chapter 4 . Discrete systems are covered in Chapters 6 and 7.  The Laplace transform treatment in Chapter 5 relies heavily on analytic function theory as does Chapter 8 on Z -transforms. The necessary background on complex variables is provided in Appendix A. This book is intended to...

  8. Emergency automatic signalling system using time scheduling

    Science.gov (United States)

    Rayavel, P.; Surenderanath, S.; Rathnavel, P.; Prakash, G.

    2018-04-01

    It is difficult to handle traffic congestion and maintain roads during traffic mainly in India. As the people migrate from rural to urban and sub-urban areas, it becomes still more critical. Presently Roadways is a standout amongst the most vital transportation. At the point when a car crash happens, crisis vehicles, for example, ambulances and fire trucks must rush to the mischance scene. There emerges a situation where a portion of the crisis vehicles may cause another car crash. Therefore it becomes still more difficult for emergency vehicle to reach the destination within a predicted time. To avoid that kind of problem we have come out with an effective idea which can reduce the potential in the traffic system. The traffic system is been modified using a wireless technology and high speed micro controller to provide smooth and clear flow of traffic for ambulance to reach the destination on time. This is achieved by using RFID Tag at the ambulance and RFID Reader at the traffic system i.e., traffic signal. This mainly deals with identifying the emergency vehicle and providing a green signal to traffic signal at time of traffic jam. — By assigning priorities to various traffic movements, we can control the traffic jam. In some moments like ambulance emergency, high delegates arrive people facing lot of trouble. To overcome this problem in this paper we propose a time priority based traffic system achieved by using RFID transmitter at the emergency vehicle and RFID receiver at the traffic system i.e., traffic signal. The signal from the emergency vehicle is sent to traffic system which after detecting it sends it to microcontroller which controls the traffic signal. If any emergency vehicle is detected the system goes to emergency system mode where signal switch to green and if it is not detected normal system mode.

  9. The Ubiquitin System and Jasmonate Signaling

    Directory of Open Access Journals (Sweden)

    Astrid Nagels Durand

    2016-01-01

    Full Text Available The ubiquitin (Ub system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for target recruitment to the proteasome or other cellular processing machineries. The Ub system contributes to the regulation of the production, perception and signal transduction of plant hormones. Jasmonic acid (JA and its derivatives, known as jasmonates (JAs, act as signaling compounds regulating plant development and plant responses to various biotic and abiotic stress conditions. We provide here an overview of the current understanding of the Ub system involved in JA signaling.

  10. Signal conditioning circuitry design for instrumentation systems.

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Cory A.

    2012-01-01

    This report details the current progress in the design, implementation, and validation of the signal conditioning circuitry used in a measurement instrumentation system. The purpose of this text is to document the current progress of a particular design in signal conditioning circuitry in an instrumentation system. The input of the signal conditioning circuitry comes from a piezoresistive transducer and the output will be fed to a 250 ksps, 12-bit analog-to-digital converter (ADC) with an input range of 0-5 V. It is assumed that the maximum differential voltage amplitude input from the sensor is 20 mV with an unknown, but presumably high, sensor bandwidth. This text focuses on a specific design; however, the theory is presented in such a way that this text can be used as a basis for future designs.

  11. Power systems signal processing for smart grids

    CERN Document Server

    Ribeiro, Paulo Fernando; Ribeiro, Paulo Márcio; Cerqueira, Augusto Santiago

    2013-01-01

    With special relation to smart grids, this book provides clear and comprehensive explanation of how Digital Signal Processing (DSP) and Computational Intelligence (CI) techniques can be applied to solve problems in the power system. Its unique coverage bridges the gap between DSP, electrical power and energy engineering systems, showing many different techniques applied to typical and expected system conditions with practical power system examples. Surveying all recent advances on DSP for power systems, this book enables engineers and researchers to understand the current state of the art a

  12. Power systems signal processing for smart grids

    NARCIS (Netherlands)

    Ribeiro, P.F.; Duque, C.A.; Da Silveira, P.M.; Cerqueira, A.S.

    2013-01-01

    With special relation to smart grids, this book provides clear and comprehensive explanation of how Digital Signal Processing (DSP) and Computational Intelligence (CI) techniques can be applied to solve problems in the power system. Its unique coverage bridges the gap between DSP, electrical power

  13. Haptic teleoperation systems signal processing perspective

    CERN Document Server

    Lee, Jae-young

    2015-01-01

    This book examines the signal processing perspective in haptic teleoperation systems. This text covers the topics of prediction, estimation, architecture, data compression, and error correction that can be applied to haptic teleoperation systems. The authors begin with an overview of haptic teleoperation systems, then look at a Bayesian approach to haptic teleoperation systems. They move onto a discussion of haptic data compression, haptic data digitization and forward error correction.   ·         Presents haptic data prediction/estimation methods that compensate for unreliable networks   ·         Discusses haptic data compression that reduces haptic data size over limited network bandwidth and haptic data error correction that compensate for packet loss problem   ·         Provides signal processing techniques used with existing control architectures.

  14. Protective role of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats.

    Science.gov (United States)

    Naresh Kumar, Rajendran; Sundaram, Ramalingam; Shanthi, Palanivelu; Sachdanandam, Panchanatham

    2013-01-05

    Hyperlipidemia is an associated complication of diabetes mellitus. The association of hyperglycemia with an alteration of lipid parameters presents a major risk for cardiovascular complications in diabetes. The present study was designed to examine the antihyperlipidemic effect of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats. The levels of blood glucose, cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density lipoprotein, high density lipoprotein, lipoprotein lipase, lecithin cholesterol acyl transferase, 3-hydroxy 3-methylglutaryl coenzyme A reductase and fatty acid composition were estimated in plasma, liver and kidneys of control and experimental groups of rats. Oral administration of 20-OH ecdysone at a dose of 5mg/kg bodyweight per day to STZ-induced diabetic rats for a period of 30 days resulted in a significant reduction in fasting blood glucose, cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density lipoprotein, 3-hydroxy 3-methylglutaryl coenzyme A reductase and elevation of high density lipoprotein, lipoprotein lipase and lecithin cholesterol acyl transferasein comparison with diabetic untreated rats. Moreover, administration of 20-OH ecdysone to diabetic rats also decreased the concentrations of fatty acids, viz., palmitic, stearic (16:1) and oleic acid (18:1), whereas linolenic (18:3) and arachidonic acid (20:4) were elevated. The antihyperlipidemic effect of 20-OH ecdysone was compared with glibenclamide a well-known antihyperglycemic drug. The result of the present study indicates that 20-OH ecdysone showed an antihyperlipidemic effect in addition to its antidiabetic effect in experimental diabetes. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Development of an in vitro binding assay for ecdysone receptor of mysid shrimp (Americamysis bahia)

    Energy Technology Data Exchange (ETDEWEB)

    Yokota, Hirofumi, E-mail: h-yokota@mail.kobe-c.ac.jp [Department of Biosphere Sciences, School of Human Sciences, Kobe College 4-1, Okadayama, Nishinomiya-shi, Hyogo 662-8505 (Japan); Eguchi, Sayaka [Department of Biosphere Sciences, School of Human Sciences, Kobe College 4-1, Okadayama, Nishinomiya-shi, Hyogo 662-8505 (Japan); Nakai, Makoto [Hita Laboratory, Chemicals Evaluation and Research Institute (CERI), 3-822, Ishii-machi, Hita-shi, Oita 877-0061 (Japan)

    2011-10-15

    Highlights: We successfully performed cDNA cloning of EcR and USP of mysid shrimp. We then expressed the ligand-binding domains of the corresponding receptor peptides. The translated peptides could bind to ecdysone agonists as heterodimers. These results indicate that they are functional hormone receptors of mysid shrimp. - Abstract: A global effort has been made to establish screening and testing methods that can identify the effects of endocrine-disrupting chemicals (EDCs) on invertebrates. The purpose of our study was to develop an in vitro receptor binding assay for ecdysone receptor (EcR) in mysid shrimp (Americamysis bahia). We cloned mysid shrimp EcR cDNA (2888 nucleotides) and ultraspiracle (USP) cDNA (2116 nucleotides), and determined that they encode predicted proteins of length 570 and 410 amino acids, respectively. The deduced amino acid sequences of these proteins shared 36-71% homology for EcR and 44-65% for USP with those of other arthropods. Phylogenetic analysis revealed that mysid shrimp EcR was classified into an independent cluster together with the EcRs of another mysid species, Neomysis integer and the cluster diverged early from those of the other taxonomic orders of crustaceans. We then expressed the ligand-binding domains (DEF regions) of mysid shrimp EcR (abEcRdef) and USP (abUSPdef) as glutathione S-transferase (GST)-fusion peptides in Escherichia coli. After purifying the fusion peptides by affinity chromatography and removing the GST labels, we subjected the peptides to a ligand-receptor binding assay. [{sup 3}H]-ponasterone A did not bind to abEcRdef or abUSPdef peptides alone but bound strongly to the abEcRdef/abUSPdef mixture with dissociation constant (K{sub d}) = 2.14 nM. Competitive binding assays showed that the IC{sub 50} values for ponasterone A, muristerone A, 20-hydroxyecdysone, and {alpha}-ecdysone were 1.2, 1.9, 35, and 1200 nM, respectively. In contrast, the IC{sub 50} values for two dibenzoylhydrazine ligands

  16. Helmet-based physiological signal monitoring system.

    Science.gov (United States)

    Kim, Youn Sung; Baek, Hyun Jae; Kim, Jung Soo; Lee, Haet Bit; Choi, Jong Min; Park, Kwang Suk

    2009-02-01

    A helmet-based system that was able to monitor the drowsiness of a soldier was developed. The helmet system monitored the electrocardiogram, electrooculogram and electroencephalogram (alpha waves) without constraints. Six dry electrodes were mounted at five locations on the helmet: both temporal sides, forehead region and upper and lower jaw strips. The electrodes were connected to an amplifier that transferred signals to a laptop computer via Bluetooth wireless communication. The system was validated by comparing the signal quality with conventional recording methods. Data were acquired from three healthy male volunteers for 12 min twice a day whilst they were sitting in a chair wearing the sensor-installed helmet. Experimental results showed that physiological signals for the helmet user were measured with acceptable quality without any intrusions on physical activities. The helmet system discriminated between the alert and drowsiness states by detecting blinking and heart rate variability (HRV) parameters extracted from ECG. Blinking duration and eye reopening time were increased during the sleepiness state compared to the alert state. Also, positive peak values of the sleepiness state were much higher, and the negative peaks were much lower than that of the alert state. The LF/HF ratio also decreased during drowsiness. This study shows the feasibility for using this helmet system: the subjects' health status and mental states could be monitored without constraints whilst they were working.

  17. Purinergic signaling pathways in endocrine system.

    Science.gov (United States)

    Bjelobaba, Ivana; Janjic, Marija M; Stojilkovic, Stanko S

    2015-09-01

    Adenosine-5'-triphosphate is released by neuroendocrine, endocrine, and other cell types and acts as an extracellular agonist for ligand-gated P2X cationic channels and G protein-coupled P2Y receptors in numerous organs and tissues, including the endocrine system. The breakdown of ATP by ectonucleotidases not only terminates its extracellular messenger functions, but also provides a pathway for the generation of two additional agonists: adenosine 5'-diphosphate, acting via some P2Y receptors, and adenosine, a native agonist for G protein-coupled adenosine receptors, also expressed in the endocrine system. This article provides a review of purinergic signaling pathways in the hypothalamic magnocellular neurosecretory cells and neurohypophysis, hypothalamic parvocellular neuroendocrine system, adenohypophysis, and effector glands organized in five axes: hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid, hypothalamic-pituitary-adrenal, hypothalamic-pituitary-growth hormone, and hypothalamic-pituitary-prolactin. We attempted to summarize current knowledge of purinergic receptor subtypes expressed in the endocrine system, including their roles in intracellular signaling, hormone secretion, and other cell functions. We also briefly review the release mechanism for adenosine-5'-triphosphate by neuroendocrine, endocrine and surrounding cells, the enzymes involved in adenosine-5'-triphosphate hydrolysis to adenosine-5'-diphosphate and adenosine, and the relevance of this pathway for sequential activation of receptors and termination of signaling. Published by Elsevier B.V.

  18. Purinergic Signaling Pathways in Endocrine System

    Science.gov (United States)

    Bjelobaba, Ivana; Janjic, Marija M.; Stojilkovic, Stanko S.

    2015-01-01

    Adenosine-5′-triphosphate is released by neuroendocrine, endocrine, and other cell types and acts as an extracellular agonist for ligand-gated P2X cationic channels and G protein-coupled P2Y receptors in numerous organs and tissues, including the endocrine system. The breakdown of ATP by ectonucleotidases not only terminates its extracellular messenger functions, but also provides a pathway for the generation of two additional agonists: adenosine 5′-diphosphate, acting via some P2Y receptors, and adenosine, a native agonist for G protein-coupled adenosine receptors, also expressed in the endocrine system. This article provides a review of purinergic signaling pathways in the hypothalamic magnocellular neurosecretory cells and neurohypophysis, hypothalamic parvocellular neuroendocrine system, adenohypophysis, and effector glands organized in five axes: hypothalamic-pituitary-gonadal, hypothalamic-pituitary-thyroid, hypothalamic-pituitary-adrenal, hypothalamic-pituitary-growth hormone, and hypothalamic-pituitary-prolactin. We attempted to summarize current knowledge of purinergic receptor subtypes expressed in the endocrine system, including their roles in intracellular signaling, hormone secretion, and other cell functions. We also briefly review the release mechanism for adenosine-5′-triphosphate by neuroendocrine, endocrine and surrounding cells, the enzymes involved in adenosine-5′-triphosphate hydrolysis to adenosine-5′-diphosphate and adenosine, and the relevance of this pathway for sequential activation of receptors and termination of signaling. PMID:25960051

  19. Multi-Modal Intelligent Traffic Signal Systems Signal Plans for Roadside Equipment

    Data.gov (United States)

    Department of Transportation — Data were collected during the Multi-Modal Intelligent Transportation Signal Systems (MMITSS) study. MMITSS is a next-generation traffic signal system that seeks to...

  20. Signals and Systems in Biomedical Engineering Signal Processing and Physiological Systems Modeling

    CERN Document Server

    Devasahayam, Suresh R

    2013-01-01

    The use of digital signal processing is ubiquitous in the field of physiology and biomedical engineering. The application of such mathematical and computational tools requires a formal or explicit understanding of physiology. Formal models and analytical techniques are interlinked in physiology as in any other field. This book takes a unitary approach to physiological systems, beginning with signal measurement and acquisition, followed by signal processing, linear systems modelling, and computer simulations. The signal processing techniques range across filtering, spectral analysis and wavelet analysis. Emphasis is placed on fundamental understanding of the concepts as well as solving numerical problems. Graphs and analogies are used extensively to supplement the mathematics. Detailed models of nerve and muscle at the cellular and systemic levels provide examples for the mathematical methods and computer simulations. Several of the models are sufficiently sophisticated to be of value in understanding real wor...

  1. General programmed system for physiological signal processing

    Energy Technology Data Exchange (ETDEWEB)

    Tournier, E; Monge, J; Magnet, C; Sonrel, C

    1975-01-01

    Improvements made to the general programmed signal acquisition and processing system, Plurimat S, are described, the aim being to obtain a less specialized system adapted to the biological and medical field. In this modified system the acquisition will be simplified. The standard processings offered will be integrated to a real advanced language which will enable the user to create his own processings, the loss of speed being compensated by a greater flexibility and universality. The observation screen will be large and the quality of the recording very good so that a large signal fraction may be displayed. The data will be easily indexed and filed for subsequent display and processing. This system will be used for two kinds of task: it can either be specialized, as an integral part of measurement and diagnostic preparation equipment used routinely in clinical work (e.g. vectocardiographic examination), or its versatility can be used for studies of limited duration to gain information in a given field or to study new diagnosis or treatment methods.

  2. Purinergic signalling in the musculoskeletal system.

    Science.gov (United States)

    Burnstock, Geoffrey; Arnett, Timothy R; Orriss, Isabel R

    2013-12-01

    It is now widely recognised that extracellular nucleotides, signalling via purinergic receptors, participate in numerous biological processes in most tissues. It has become evident that extracellular nucleotides have significant regulatory effects in the musculoskeletal system. In early development, ATP released from motor nerves along with acetylcholine acts as a cotransmitter in neuromuscular transmission; in mature animals, ATP functions as a neuromodulator. Purinergic receptors expressed by skeletal muscle and satellite cells play important pathophysiological roles in their development or repair. In many cell types, expression of purinergic receptors is often dependent on differentiation. For example, sequential expression of P2X5, P2Y1 and P2X2 receptors occurs during muscle regeneration in the mdx model of muscular dystrophy. In bone and cartilage cells, the functional effects of purinergic signalling appear to be largely negative. ATP stimulates the formation and activation of osteoclasts, the bone-destroying cells. Another role appears to be as a potent local inhibitor of mineralisation. In osteoblasts, the bone-forming cells, ATP acts via P2 receptors to limit bone mineralisation by inhibiting alkaline phosphatase expression and activity. Extracellular ATP additionally exerts significant effects on mineralisation via its hydrolysis product, pyrophosphate. Evidence now suggests that purinergic signalling is potentially important in several bone and joint disorders including osteoporosis, rheumatoid arthritis and cancers. Strategies for future musculoskeletal therapies might involve modulation of purinergic receptor function or of the ecto-nucleotidases responsible for ATP breakdown or ATP transport inhibitors.

  3. Simulation of traffic control signal systems

    Science.gov (United States)

    Connolly, P. J.; Concannon, P. A.; Ricci, R. C.

    1974-01-01

    In recent years there has been considerable interest in the development and testing of control strategies for networks of urban traffic signal systems by simulation. Simulation is an inexpensive and timely method for evaluating the effect of these traffic control strategies since traffic phenomena are too complex to be defined by analytical models and since a controlled experiment may be hazardous, expensive, and slow in producing meaningful results. This paper describes the application of an urban traffic corridor program, to evaluate the effectiveness of different traffic control strategies for the Massachusetts Avenue TOPICS Project.

  4. Multi-Modal Intelligent Traffic Signal Systems GPS

    Data.gov (United States)

    Department of Transportation — Data were collected during the Multi-Modal Intelligent Transportation Signal Systems (MMITSS) study. MMITSS is a next-generation traffic signal system that seeks to...

  5. Signal systems asset management state-of-the-practice review

    Science.gov (United States)

    2004-04-01

    The purpose of this project is to obtain a better understanding of operations-level asset management by examining the specific case of signal systems. Key products will include: a synthesis of existing signal systems asset management practices; a gen...

  6. System and method for traffic signal timing estimation

    KAUST Repository

    Dumazert, Julien; Claudel, Christian G.

    2015-01-01

    A method and system for estimating traffic signals. The method and system can include constructing trajectories of probe vehicles from GPS data emitted by the probe vehicles, estimating traffic signal cycles, combining the estimates, and computing the traffic signal timing by maximizing a scoring function based on the estimates. Estimating traffic signal cycles can be based on transition times of the probe vehicles starting after a traffic signal turns green.

  7. System and method for traffic signal timing estimation

    KAUST Repository

    Dumazert, Julien

    2015-12-30

    A method and system for estimating traffic signals. The method and system can include constructing trajectories of probe vehicles from GPS data emitted by the probe vehicles, estimating traffic signal cycles, combining the estimates, and computing the traffic signal timing by maximizing a scoring function based on the estimates. Estimating traffic signal cycles can be based on transition times of the probe vehicles starting after a traffic signal turns green.

  8. Phase transition signals of finite systems

    International Nuclear Information System (INIS)

    Duflot-Flandrois, Veronique

    2001-01-01

    Phase transitions are universal properties of interacting matter. They are well described if the considered system is infinite, by using standard thermodynamics. But in the case of small systems like atomic nuclei, this formalism cannot be applied anymore. Our aim is to propose a statistical mechanics approach in order to define the thermodynamical features of small open systems subject to non-saturating forces. We concentrate in particular on the definition and characterization for such systems of phase transitions belonging to the liquid gas universality class. Theoretical and experimental observables are defined to signal the occurrence and the order of this transition without any ambiguity. One of the most relevant and experimentally accessible observables consists in the study of kinetic energy fluctuations for a fixed value of the total deposited energy. In a first order phase transition such fluctuations become anomaly high and at the same time the size distribution appears to behave critically. All our results are obtained within numerical simulations of the lattice gas model with a nearest neighbors attractive interaction. Finally we check the influence of non-saturating forces, developing the specific example of the Coulomb interaction in the nucleus. Future improvements and perspectives at this work consist in the analysis of specific effects occurring in nuclei: isospin and quantum mechanics. (author) [fr

  9. An Assessment Methodology for Emergency Vehicle Traffic Signal Priority Systems

    OpenAIRE

    McHale, Gene Michael

    2002-01-01

    Emergency vehicle traffic signal priority systems allow emergency vehicles such as fire and emergency medical vehicles to request and receive a green traffic signal indication when approaching an intersection. Such systems have been around for a number of years, however, there is little understanding of the costs and benefits of such systems once they are deployed. This research develops an improved method to assess the travel time impacts of emergency vehicle traffic signal priority system...

  10. Jamming Signal Reduction in Spread Spectrum Systems.

    Science.gov (United States)

    1979-04-26

    the addition of an appropriate equalizer netowrk . The original signal and the estimate of the jamming signal are matched and added by a resistor...ADDRESS(SI different from Controllln~ OWce) IS. SECURITY CLASS. (of this report) Unclassified IS.. OECLASSIFICATION /DOWNGRAD IHO SCHEDULE $6. DISTRIB

  11. The P450 enzyme Shade mediates the hydroxylation of ecdysone to 20-hydroxyecdysone in the Colorado potato beetle, Leptinotarsa decemlineata.

    Science.gov (United States)

    Kong, Y; Liu, X-P; Wan, P-J; Shi, X-Q; Guo, W-C; Li, G-Q

    2014-10-01

    Ecdysone 20-monooxygenase (E20MO), a cytochrome P450 monooxygenase (CYP314A1), catalyses the conversion of ecdysone (E) to 20-hydroxyecdysone (20E). We report here the cloning and characterization of the Halloween gene Shade (Shd) encoding E20MO in the Colorado potato beetle, Leptinotarsa decemlineata. LdSHD has five conserved motifs typical of insect P450s, ie the Helix-C, Helix-I, Helix-K, PxxFxPE/DRF (PERF) and heme-binding motifs. LdShd was expressed in developing eggs, the first to fourth instars, wandering larvae, pupae and adults, with statistically significant fluctuations. Its mRNA was ubiquitously distributed in the head, thorax and abdomen. The recombinant LdSHD protein expressed in Spodoptera frugiperda 9 (Sf9) cells catalysed the conversion of E to 20E. Dietary introduction of double-stranded RNA (dsRNA) of LdShd into the second instar larvae successfully knocked down the LdShd expression level, decreased the mRNA level of the ecdysone receptor (LdEcR) gene, caused larval lethality, delayed development and affected pupation. Moreover, ingestion of LdShd-dsRNA by the fourth instars also down-regulated LdShd and LdEcR expression, reduced the 20E titre, and negatively influenced pupation. Introduction of 20E and a nonsteroidal ecdysteroid agonist halofenozide into the LdShd-dsRNA-ingested second instars, and of halofenozide into the LdShd-dsRNA-ingested fourth instars almost completely relieved the negative effects on larval performance. Thus, LdSHD functions to regulate metamorphotic processes by converting E to 20E in a coleopteran insect species Le. decemlineata. © 2014 The Royal Entomological Society.

  12. The insect ecdysone receptor is a good potential target for RNAi-based pest control.

    Science.gov (United States)

    Yu, Rong; Xu, Xinping; Liang, Yongkang; Tian, Honggang; Pan, Zhanqing; Jin, Shouheng; Wang, Na; Zhang, Wenqing

    2014-01-01

    RNA interference (RNAi) has great potential for use in insect pest control. However, some significant challenges must be overcome before RNAi-based pest control can become a reality. One challenge is the proper selection of a good target gene for RNAi. Here, we report that the insect ecdysone receptor (EcR) is a good potential target for RNAi-based pest control in the brown planthopper Nilaparvata lugens, a serious insect pest of rice plants. We demonstrated that the use of a 360 bp fragment (NlEcR-c) that is common between NlEcR-A and NlEcR-B for feeding RNAi experiments significantly decreased the relative mRNA expression levels of NlEcR compared with those in the dsGFP control. Feeding RNAi also resulted in a significant reduction in the number of offspring per pair of N. lugens. Consequently, a transgenic rice line expressing NlEcR dsRNA was constructed by Agrobacterium- mediated transformation. The results of qRT-PCR showed that the total copy number of the target gene in all transgenic rice lines was 2. Northern blot analysis showed that the small RNA of the hairpin dsNlEcR-c was successfully expressed in the transgenic rice lines. After newly hatched nymphs of N. lugens fed on the transgenic rice lines, effective RNAi was observed. The NlEcR expression levels in all lines examined were decreased significantly compared with the control. In all lines, the survival rate of the nymphs was nearly 90%, and the average number of offspring per pair in the treated groups was significantly less than that observed in the control, with a decrease of 44.18-66.27%. These findings support an RNAi-based pest control strategy and are also important for the management of rice insect pests.

  13. Behavioral Sensitization to the Disinhibition Effect of Ethanol Requires the Dopamine/Ecdysone Receptor in Drosophila

    Directory of Open Access Journals (Sweden)

    Gissel P. Aranda

    2017-08-01

    Full Text Available Male flies under the influence of ethanol display disinhibited courtship, which is augmented with repeated ethanol exposures. We have previously shown that dopamine is important for this type of ethanol-induced behavioral sensitization but the underlying mechanism is unknown. Here we report that DopEcR, an insect G-protein coupled receptor that binds to dopamine and steroid hormone ecdysone, is a major receptor mediating courtship sensitization. Upon daily ethanol administration, dumb and damb mutant males defective in D1 (dDA1/DopR1 and D5 (DAMB/DopR2 dopamine receptors, respectively, showed normal courtship sensitization; however, the DopEcR-deficient der males exhibited greatly diminished sensitization. der mutant males nevertheless developed normal tolerance to the sedative effect of ethanol, indicating a selective function of DopEcR in chronic ethanol-associated behavioral plasticity. DopEcR plays a physiological role in behavioral sensitization since courtship sensitization in der males was reinstated when DopEcR expression was induced during adulthood but not during development. When examined for the DopEcR’s functional site, the der mutant’s sensitization phenotype was fully rescued by restored DopEcR expression in the mushroom body (MB αβ and γ neurons. Consistently, we observed DopEcR immunoreactivity in the MB calyx and lobes in the wild-type Canton-S brain, which was barely detectable in the der brain. Behavioral sensitization to the locomotor-stimulant effect has been serving as a model for ethanol abuse and addiction. This is the first report elucidating the mechanism underlying behavioral sensitization to another stimulant effect of ethanol.

  14. Information content in reflected global navigation satellite system signals

    DEFF Research Database (Denmark)

    Høeg, Per; Carlstrom, Anders

    2011-01-01

    The direct signals from satellites in global satellite navigation satellites systems (GNSS) as, GPS, GLONASS and GALILEO, constitute the primary source for positioning, navigation and timing from space. But also the reflected GNSS signals contain an important information content of signal travel...

  15. Utilization of excitation signal harmonics for control of nonlinear systems

    DEFF Research Database (Denmark)

    Vinther, Kasper; Rasmussen, Henrik; Izadi-Zamanabadi, Roozbeh

    2012-01-01

    signal together with Fourier analysis to generate a feedback signal and simulations have shown that different system gains and time constants does not change the global equilibrium/operating point. An evaporator in a refrigeration system was used as example in the simulations, however, it is anticipated...... that the method is applicable in a wide variety of systems satisfying the sigmoid function properties....

  16. 21 CFR 870.2600 - Signal isolation system.

    Science.gov (United States)

    2010-04-01

    ... system. (a) Identification. A signal isolation system is a device that electrically isolates the patient... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Signal isolation system. 870.2600 Section 870.2600 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED...

  17. Towards Signalling Maintenance Scheduling for European Railway Traffic Management System

    DEFF Research Database (Denmark)

    M. Pour, Shahrzad

    signalling system. Therefore, the entire maintenance system needs to change from the previous system to the newest system, and hence, new optimisation techniques need to be established so as to facilitate managers in creating ideal maintenance strategies. The aim of this thesis is to develop new maintenance......The European Railway Traffic Management System (ERTMS) is the newest signalling standard that has been introduced in the railway industry. The aim of ERTMS is to ensure better signalling communication amongst various train systems, and hence, to help in attaining improved connectivity and commuting...... between European countries. In various countries across the world, there is a gradual shift from the current signalling systems to ERTMS. Amongst the European countries, Denmark was the first country to commence a full upgrading of its signalling system to ERTMS. A variety of maintenance requirements...

  18. Unified Digital Periodic Signal Filters for Power Converter Systems

    DEFF Research Database (Denmark)

    Yang, Yongheng; Xin, Zhen; Zhou, Keliang

    2017-01-01

    Periodic signal controllers like repetitive and resonant controllers have demonstrated much potential in the control of power electronic converters, where periodic signals (e.g., ac voltages and currents) can be precisely regulated to follow references. Beyond the control of periodic signals, ac...... signal processing (e.g., in synchronization and pre-filtering) is also very important for power converter systems. Hence, this paper serves to unify digital periodic signal filters so as to maximize their roles in power converter systems (e.g., enhance the control of ac signals). The unified digital...... periodic signal filters behave like a comb filter, but it can also be configured to selectively filter out the harmonics of interest (e.g., the odd-order harmonics in single-phase power converter systems). Moreover, a virtual variable-sampling-frequency unit delay that enables frequency adaptive periodic...

  19. Insulin signaling pathways in lepidopteran steroidogenesis

    Directory of Open Access Journals (Sweden)

    Wendy eSmith

    2014-02-01

    Full Text Available Molting and metamorphosis are stimulated by the secretion of ecdysteroid hormones from the prothoracic glands. Insulin-like hormones have been found to enhance prothoracic gland activity, providing a mechanism to link molting to nutritional state. In silk moths (Bombyx mori, the prothoracic glands are directly stimulated by insulin and the insulin-like hormone bombyxin. Further, in Bombyx , the neuropeptide prothoracicotropic hormone (PTTH appears to act at least in part through the insulin-signaling pathway. In the prothoracic glands of Manduca sexta, while insulin stimulates the phosphorylation of the insulin receptor and Akt, neither insulin nor bombyxin II stimulate ecdysone secretion. Involvement of the insulin-signaling pathway in Manduca prothoracic glands was explored using two inhibitors of phosphatidylinositol-3-kinase (PI3K, LY294002 and wortmannin. PI3K inhibitors block the phosphorylation of Akt and 4EBP but have no effect on ecdysone secretion, or on the phosphorylation of the MAPkinase, ERK. Inhibitors that block phosphorylation of ERK, including the MEK inhibitor U0126, and high doses of the RSK inhibitor SL0101, effectively inhibit ecdysone secretion. The results highlight differences between the two lepidopteran insects most commonly used to directly study ecdysteroid secretion. In Bombyx, the PTTH and insulin-signaling pathways intersect; both insulin and PTTH enhance the phosphorylation of Akt and stimulate ecdysteroid secretion, and inhibition of PI3K reduces ecdysteroid secretion. By contrast, in Manduca, the action of PTTH is distinct from insulin. The results highlight species differences in the roles of translational regulators such as 4EBP, and members of the MAPkinase pathway such as ERK and RSK, in the effects of nutritionally-sensitive hormones such as insulin on ecdysone secretion and molting.

  20. System and Method for Multi-Wavelength Optical Signal Detection

    Science.gov (United States)

    McGlone, Thomas D. (Inventor)

    2017-01-01

    The system and method for multi-wavelength optical signal detection enables the detection of optical signal levels significantly below those processed at the discrete circuit level by the use of mixed-signal processing methods implemented with integrated circuit technologies. The present invention is configured to detect and process small signals, which enables the reduction of the optical power required to stimulate detection networks, and lowers the required laser power to make specific measurements. The present invention provides an adaptation of active pixel networks combined with mixed-signal processing methods to provide an integer representation of the received signal as an output. The present invention also provides multi-wavelength laser detection circuits for use in various systems, such as a differential absorption light detection and ranging system.

  1. Structural diversity and evolution of the N-terminal isoform-specific region of ecdysone receptor-A and -B1 isoforms in insects

    Directory of Open Access Journals (Sweden)

    Kubo Takeo

    2010-02-01

    Full Text Available Abstract Background The ecdysone receptor (EcR regulates various cellular responses to ecdysteroids during insect development. Insects have multiple EcR isoforms with different N-terminal A/B domains that contain the isoform-specific activation function (AF-1 region. Although distinct physiologic functions of the EcR isoforms have been characterized in higher holometabolous insects, they remain unclear in basal direct-developing insects, in which only A isoform has been identified. To examine the structural basis of the EcR isoform-specific AF-1 regions, we performed a comprehensive structural comparison of the isoform-specific region of the EcR-A and -B1 isoforms in insects. Results The EcR isoforms were newly identified in 51 species of insects and non-insect arthropods, including direct-developing ametabolous and hemimetabolous insects. The comprehensive structural comparison revealed that the isoform-specific region of each EcR isoform contained evolutionally conserved microdomain structures and insect subgroup-specific structural modifications. The A isoform-specific region generally contained four conserved microdomains, including the SUMOylation motif and the nuclear localization signal, whereas the B1 isoform-specific region contained three conserved microdomains, including an acidic activator domain-like motif. In addition, the EcR-B1 isoform of holometabolous insects had a novel microdomain at the N-terminal end. Conclusions Given that the nuclear receptor AF-1 is involved in cofactor recruitment and transcriptional regulation, the microdomain structures identified in the isoform-specific A/B domains might function as signature motifs and/or as targets for cofactor proteins that play essential roles in the EcR isoform-specific AF-1 regions. Moreover, the novel microdomain in the isoform-specific region of the holometabolous insect EcR-B1 isoform suggests that the holometabolous insect EcR-B1 acquired additional transcriptional

  2. Development of signal acquisition device of rotating coil measurement system

    International Nuclear Information System (INIS)

    Zhou Jianxin; Li Li; Kang Wen; Deng Chengdong; Yin Baogui; Fu Shinian

    2013-01-01

    A new rotating coil magnetic measurement system using the technical solution of the combination of a dynamic signal acquisition card and software with specific functions was developed. The acquisition device of the system successfully implemented the function of the PDI-5025 integrator. The sampling rate, the range, the accuracy and the flexibility of the system were improved. The development program of signal acquisition equipment, the realization of the acquisition function and the reliability and stability of the system were introduced. (authors)

  3. Effects of both ecdysone and the acclimation to low temperature, on growth and metabolic rate of juvenile freshwater crayfish Cherax quadricarinatus (Decapoda, Parastacidae

    Directory of Open Access Journals (Sweden)

    Anouk Chaulet

    2013-06-01

    Full Text Available Growth, metabolic rate, and energy reserves of Cherax quadricarinatus (von Martens, 1868 juveniles were evaluated in crayfish acclimated for 16 weeks to either 25ºC (temperature near optimum or 20ºC (marginal for the species. Additionally, the modulating effect of ecdsyone on acclimation was studied. After 12 weeks of exposure, weight gain of both experimental groups acclimated to 25ºC (control: C25, and ecdysone treated: E25 was significantly higher than that of those groups acclimated to 20ºC (C20 and E20. A total compensation in metabolic rate was seen after acclimation from 25ºC to 20ºC; for both the control group and the group treated with ecdysone. A Q10value significantly higher was only observed in the group acclimated to 20ºC and treated with ecdysone. A reduction of glycogen reserves in both hepatopancreas and muscle, as well as a lower protein content in muscle, was seen in both groups acclimated to 20ºC. Correspondingly, glycemia was always higher in these groups. Increased lipid levels were seen in the hepatopancreas of animals acclimated to 20ºC, while a higher lipid level was also observed in muscle at 20ºC, but only in ecdysone-treated crayfish.

  4. A New Indoor Positioning System Architecture Using GPS Signals.

    Science.gov (United States)

    Xu, Rui; Chen, Wu; Xu, Ying; Ji, Shengyue

    2015-04-29

    The pseudolite system is a good alternative for indoor positioning systems due to its large coverage area and accurate positioning solution. However, for common Global Positioning System (GPS) receivers, the pseudolite system requires some modifications of the user terminals. To solve the problem, this paper proposes a new pseudolite-based indoor positioning system architecture. The main idea is to receive real-world GPS signals, repeat each satellite signal and transmit those using indoor transmitting antennas. The transmitted GPS-like signal can be processed (signal acquisition and tracking, navigation data decoding) by the general receiver and thus no hardware-level modification on the receiver is required. In addition, all Tx can be synchronized with each other since one single clock is used in Rx/Tx. The proposed system is simulated using a software GPS receiver. The simulation results show the indoor positioning system is able to provide high accurate horizontal positioning in both static and dynamic situations.

  5. Development of knowledgebase system for assisting signal validation scheme design

    International Nuclear Information System (INIS)

    Kitamura, M.; Baba, T.; Washio, T.; Sugiyama, K.

    1987-01-01

    The purpose of this study is to develop a knowledgebase system to be used as a tool for designing signal validation schemes. The outputs from the signal validation scheme can be used as; (1) auxiliary signals for detecting sensor failures, (2) inputs to advanced instrumentation such as disturbance analysis and diagnosis system or safety parameter display system, and (3) inputs to digital control systems. Conventional signal validation techniques such as comparison of redundant sensors, limit checking, and calibration tests have been employed in nuclear power plants. However, these techniques have serious drawbacks, e.g. needs for extra sensors, vulnerability to common mode failures, limited applicability to continuous monitoring, etc. To alleviate these difficulties, a new signal validation technique has been developed by using the methods called analytic redundancy and parity space. Although the new technique has been proved feasible as far as preliminary tests are concerned, further developments should be made in order to enhance its practical applicability

  6. The Signal Validation method of Digital Process Instrumentation System on signal conditioner for SMART

    International Nuclear Information System (INIS)

    Moon, Hee Gun; Park, Sang Min; Kim, Jung Seon; Shon, Chang Ho; Park, Heui Youn; Koo, In Soo

    2005-01-01

    The function of PIS(Process Instrumentation System) for SMART is to acquire the process data from sensor or transmitter. The PIS consists of signal conditioner, A/D converter, DSP(Digital Signal Process) and NIC(Network Interface Card). So, It is fully digital system after A/D converter. The PI cabinet and PDAS(Plant Data Acquisition System) in commercial plant is responsible for data acquisition of the sensor or transmitter include RTD, TC, level, flow, pressure and so on. The PDAS has the software that processes each sensor data and PI cabinet has the signal conditioner, which is need for maintenance and test. The signal conditioner has the potentiometer to adjust the span and zero for test and maintenance. The PIS of SMART also has the signal conditioner which has the span and zero adjust same as the commercial plant because the signal conditioner perform the signal condition for AD converter such as 0∼10Vdc. But, To adjust span and zero is manual test and calibration. So, This paper presents the method of signal validation and calibration, which is used by digital feature in SMART. There are I/E(current to voltage), R/E(resistor to voltage), F/E(frequency to voltage), V/V(voltage to voltage). Etc. In this paper show only the signal validation and calibration about I/E converter that convert level, pressure, flow such as 4∼20mA into signal for AD conversion such as 0∼10Vdc

  7. Signals, processes, and systems an interactive multimedia introduction to signal processing

    CERN Document Server

    Karrenberg, Ulrich

    2013-01-01

    This is a very new concept for learning Signal Processing, not only from the physically-based scientific fundamentals, but also from the didactic perspective, based on modern results of brain research. The textbook together with the DVD form a learning system that provides investigative studies and enables the reader to interactively visualize even complex processes. The unique didactic concept is built on visualizing signals and processes on the one hand, and on graphical programming of signal processing systems on the other. The concept has been designed especially for microelectronics, computer technology and communication. The book allows to develop, modify, and optimize useful applications using DasyLab - a professional and globally supported software for metrology and control engineering. With the 3rd edition, the software is also suitable for 64 bit systems running on Windows 7. Real signals can be acquired, processed and played on the sound card of your computer. The book provides more than 200 pre-pr...

  8. Flash signal evolution in Photinus fireflies: character displacement and signal exploitation in a visual communication system.

    Science.gov (United States)

    Stanger-Hall, Kathrin F; Lloyd, James E

    2015-03-01

    Animal communication is an intriguing topic in evolutionary biology. In this comprehensive study of visual signal evolution, we used a phylogenetic approach to study the evolution of the flash communication system of North American fireflies. The North American firefly genus Photinus contains 35 described species with simple ON-OFF visual signals, and information on habitat types, sympatric congeners, and predators. This makes them an ideal study system to test hypotheses on the evolution of male and female visual signal traits. Our analysis of 34 Photinus species suggests two temporal pattern generators: one for flash duration and one for flash intervals. Reproductive character displacement was a main factor for signal divergence in male flash duration among sympatric Photinus species. Male flash pattern intervals (i.e., the duration of the dark periods between signals) were positively correlated with the number of sympatric Photuris fireflies, which include predators of Photinus. Females of different Photinus species differ in their response preferences to male traits. As in other communication systems, firefly male sexual signals seem to be a compromise between optimizing mating success (sexual selection) and minimizing predation risk (natural selection). An integrative model for Photinus signal evolution is proposed. © 2015 The Author(s).

  9. Measurement System for Playout Delay of TV Signals

    NARCIS (Netherlands)

    Kooij, W.J.; Stokking, H.M.; Brandenburg, R. van; Boer, P.T. de

    2014-01-01

    TV signals are carried towards end-users using different (broadcast) technologies and by different providers. This is causing differences in the playout timing of the TV signal at different locations and devices. Authors have developed a measurement system for measuring the relative playout delay of

  10. Auditory signal design for automatic number plate recognition system

    NARCIS (Netherlands)

    Heydra, C.G.; Jansen, R.J.; Van Egmond, R.

    2014-01-01

    This paper focuses on the design of an auditory signal for the Automatic Number Plate Recognition system of Dutch national police. The auditory signal is designed to alert police officers of suspicious cars in their proximity, communicating priority level and location of the suspicious car and

  11. The Wigner distribution function applied to optical signals and systems

    NARCIS (Netherlands)

    Bastiaans, M.J.

    1978-01-01

    In this paper the Wigner distribution function has been introduced for optical signals and systems. The Wigner distribution function of an optical signal appears to be in close resemblance to the ray concept in geometrical optics. This resemblance reaches even farther: although derived from Fourier

  12. A review of intelligent systems for heart sound signal analysis.

    Science.gov (United States)

    Nabih-Ali, Mohammed; El-Dahshan, El-Sayed A; Yahia, Ashraf S

    2017-10-01

    Intelligent computer-aided diagnosis (CAD) systems can enhance the diagnostic capabilities of physicians and reduce the time required for accurate diagnosis. CAD systems could provide physicians with a suggestion about the diagnostic of heart diseases. The objective of this paper is to review the recent published preprocessing, feature extraction and classification techniques and their state of the art of phonocardiogram (PCG) signal analysis. Published literature reviewed in this paper shows the potential of machine learning techniques as a design tool in PCG CAD systems and reveals that the CAD systems for PCG signal analysis are still an open problem. Related studies are compared to their datasets, feature extraction techniques and the classifiers they used. Current achievements and limitations in developing CAD systems for PCG signal analysis using machine learning techniques are presented and discussed. In the light of this review, a number of future research directions for PCG signal analysis are provided.

  13. Power system small signal stability analysis and control

    CERN Document Server

    Mondal, Debasish; Sengupta, Aparajita

    2014-01-01

    Power System Small Signal Stability Analysis and Control presents a detailed analysis of the problem of severe outages due to the sustained growth of small signal oscillations in modern interconnected power systems. The ever-expanding nature of power systems and the rapid upgrade to smart grid technologies call for the implementation of robust and optimal controls. Power systems that are forced to operate close to their stability limit have resulted in the use of control devices by utility companies to improve the performance of the transmission system against commonly occurring power system

  14. An implantable CMOS signal conditioning system for recording nerve signals with cuff electrodes

    DEFF Research Database (Denmark)

    Papathanasiou, Konstantinos; Lehmann, Torsten

    2000-01-01

    We propose a system architecture for recording nerve signals with cuff electrodes and develop the key component in this system, the small-input, low-noise, low-power, high-gain amplifier. The amplifier is implemented using a mixture of weak- and strong-inversion transistors and a special off-set ......-set compensation technique; its performance is validated using Spice simulations....

  15. Barter System Signals Harmony in Causality

    OpenAIRE

    Toncheva, Rossitsa

    2013-01-01

    "Is there money involvement in seemingly pure barter transactions?" or “Will we came back to "penniless" exchange?” The answer is looking into our concept about barter according to our concept of money. Refracted through the corporate paradigm, the barter system is an economic group. Relationships within the group correspond to the free economy paradigm /pure market economy/. Some financial features occur in pure form in the barter system. Relationships of this kind include: income, the barte...

  16. Modelling of Signal - Level Crossing System

    Directory of Open Access Journals (Sweden)

    Daniel Novak

    2006-01-01

    Full Text Available The author presents an object-oriented model of a railway level-crossing system created for the purpose of functional requirements specification. Unified Modelling Language (UML, version 1.4, which enables specification, visualisation, construction and documentation of software system artefacts, was used. The main attention was paid to analysis and design phases. The former phase resulted in creation of use case diagrams and sequential diagrams, the latter in creation of class/object diagrams and statechart diagrams.

  17. Estimating parameters of chaotic systems synchronized by external driving signal

    International Nuclear Information System (INIS)

    Wu Xiaogang; Wang Zuxi

    2007-01-01

    Noise-induced synchronization (NIS) has evoked great research interests recently. Two uncoupled identical chaotic systems can achieve complete synchronization (CS) by feeding a common noise with appropriate intensity. Actually, NIS belongs to the category of external feedback control (EFC). The significance of applying EFC in secure communication lies in fact that the trajectory of chaotic systems is disturbed so strongly by external driving signal that phase space reconstruction attack fails. In this paper, however, we propose an approach that can accurately estimate the parameters of the chaotic systems synchronized by external driving signal through chaotic transmitted signal, driving signal and their derivatives. Numerical simulation indicates that this approach can estimate system parameters and external coupling strength under two driving modes in a very rapid manner, which implies that EFC is not superior to other methods in secure communication

  18. 4th International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Mu, Jiasong; Wang, Wei; Zhang, Baoju

    2016-01-01

    This book brings together papers presented at the 4th International Conference on Communications, Signal Processing, and Systems, which provides a venue to disseminate the latest developments and to discuss the interactions and links between these multidisciplinary fields. Spanning topics ranging from Communications, Signal Processing and Systems, this book is aimed at undergraduate and graduate students in Electrical Engineering, Computer Science and Mathematics, researchers and engineers from academia and industry as well as government employees (such as NSF, DOD, DOE, etc).

  19. Digital signal processing in power system protection and control

    CERN Document Server

    Rebizant, Waldemar; Wiszniewski, Andrzej

    2011-01-01

    Digital Signal Processing in Power System Protection and Control bridges the gap between the theory of protection and control and the practical applications of protection equipment. Understanding how protection functions is crucial not only for equipment developers and manufacturers, but also for their users who need to install, set and operate the protection devices in an appropriate manner. After introductory chapters related to protection technology and functions, Digital Signal Processing in Power System Protection and Control presents the digital algorithms for signal filtering, followed

  20. Emergency vehicle traffic signal preemption system

    Science.gov (United States)

    Bachelder, Aaron D. (Inventor); Foster, Conrad F. (Inventor)

    2011-01-01

    An emergency vehicle traffic light preemption system for preemption of traffic lights at an intersection to allow safe passage of emergency vehicles. The system includes a real-time status monitor of an intersection which is relayed to a control module for transmission to emergency vehicles as well as to a central dispatch office. The system also provides for audio warnings at an intersection to protect pedestrians who may not be in a position to see visual warnings or for various reasons cannot hear the approach of emergency vehicles. A transponder mounted on an emergency vehicle provides autonomous control so the vehicle operator can attend to getting to an emergency and not be concerned with the operation of the system. Activation of a priority-code (i.e. Code-3) situation provides communications with each intersection being approached by an emergency vehicle and indicates whether the intersection is preempted or if there is any conflict with other approaching emergency vehicles. On-board diagnostics handle various information including heading, speed, and acceleration sent to a control module which is transmitted to an intersection and which also simultaneously receives information regarding the status of an intersection. Real-time communications and operations software allow central and remote monitoring, logging, and command of intersections and vehicles.

  1. A Measurement System of Electric Signals on Standing Trees

    Directory of Open Access Journals (Sweden)

    Hao TIAN

    2014-01-01

    Full Text Available The standing tree electric signal (STES, defined as the electric potential difference between standing trees and the surrounding soil, can be utilized to reflect the biological nature of the trees. This signal should be measured precisely because it can also be collected and used as the electric power energy. In this paper, the automatic measurement system of standing tree biological electric signal based on MSP430 MCU. First of all, the basic structure of the presented system is introduced and it includes three modules: amplification module of the standing tree electric signal, the acquisition and processing of the signal module and the serial communication module. Then, the performances of the built system are respectively validated by the Poplar, Planetree, and Platanus in Beijing Forestry University. The result indicated that the relative error of this system is less than 2 %. The presented system can be considered as the foundation of the subsequent study on the mechanism of the biological electric signal and the application of the biological electric energy on standing trees.

  2. A Bioassay System Using Bioelectric Signals from Small Fish

    Science.gov (United States)

    Terawaki, Mitsuru; Soh, Zu; Hirano, Akira; Tsuji, Toshio

    Although the quality of tap water is generally examined using chemical assay, this method cannot be used for examination in real time. Against such a background, the technique of fish bioassay has attracted attention as an approach that enables constant monitoring of aquatic contamination. The respiratory rhythms of fish are considered an efficient indicator for the ongoing assessment of water quality, since they are sensitive to chemicals and can be indirectly measured from bioelectric signals generated by breathing. In order to judge aquatic contamination accurately, it is necessary to measure bioelectric signals from fish swimming freely as well as to stably discriminate measured signals, which vary between individuals. However, no bioassay system meeting the above requirements has yet been established. This paper proposes a bioassay system using bioelectric signals generated from small fish in free-swimming conditions. The system records signals using multiple electrodes to cover the extensive measurement range required in a free-swimming environment, and automatically discriminates changes in water quality from signal frequency components. This discrimination is achieved through an ensemble classification method using probability neural networks to solve the problem of differences between individual fish. The paper also reports on the results of related validation experiments, which showed that the proposed system was able to stably discriminate between water conditions before and after bleach exposure.

  3. Medical Signal-Conditioning and Data-Interface System

    Science.gov (United States)

    Braun, Jeffrey; Jacobus, charles; Booth, Scott; Suarez, Michael; Smith, Derek; Hartnagle, Jeffrey; LePrell, Glenn

    2006-01-01

    A general-purpose portable, wearable electronic signal-conditioning and data-interface system is being developed for medical applications. The system can acquire multiple physiological signals (e.g., electrocardiographic, electroencephalographic, and electromyographic signals) from sensors on the wearer s body, digitize those signals that are received in analog form, preprocess the resulting data, and transmit the data to one or more remote location(s) via a radiocommunication link and/or the Internet. The system includes a computer running data-object-oriented software that can be programmed to configure the system to accept almost any analog or digital input signals from medical devices. The computing hardware and software implement a general-purpose data-routing-and-encapsulation architecture that supports tagging of input data and routing the data in a standardized way through the Internet and other modern packet-switching networks to one or more computer(s) for review by physicians. The architecture supports multiple-site buffering of data for redundancy and reliability, and supports both real-time and slower-than-real-time collection, routing, and viewing of signal data. Routing and viewing stations support insertion of automated analysis routines to aid in encoding, analysis, viewing, and diagnosis.

  4. Calcium signal communication in the central nervous system.

    Science.gov (United States)

    Braet, Katleen; Cabooter, Liesbet; Paemeleire, Koen; Leybaert, Luc

    2004-02-01

    The communication of calcium signals between cells is known to be operative between neurons where these signals integrate intimately with electrical and chemical signal communication at synapses. Recently, it has become clear that glial cells also exchange calcium signals between each other in cultures and in brain slices. This communication pathway has received utmost attention since it is known that astrocytic calcium signals can be induced by neuronal stimulation and can be communicated back to the neurons to modulate synaptic transmission. In addition to this, cells that are generally not considered as brain cells become progressively incorporated in the picture, as astrocytic calcium signals are reported to be communicated to endothelial cells of the vessel wall and can affect smooth muscle cell tone to influence the vessel diameter and thus blood flow. We review the available evidence for calcium signal communication in the central nervous system, taking into account a basic functional unit -the brain cell tripartite- consisting of neurons, glial cells and vascular cells and with emphasis on glial-vascular calcium signaling aspects.

  5. System and method for detection of dispersed broadband signals

    Science.gov (United States)

    Qian, S.; Dunham, M.E.

    1999-06-08

    A system and method for detecting the presence of dispersed broadband signals in real time are disclosed. The present invention utilizes a bank of matched filters for detecting the received dispersed broadband signals. Each matched filter uses a respective robust time template that has been designed to approximate the dispersed broadband signals of interest, and each time template varies across a spectrum of possible dispersed broadband signal time templates. The received dispersed broadband signal x(t) is received by each of the matched filters, and if one or more matches occurs, then the received data is determined to have signal data of interest. This signal data can then be analyzed and/or transmitted to Earth for analysis, as desired. The system and method of the present invention will prove extremely useful in many fields, including satellite communications, plasma physics, and interstellar research. The varying time templates used in the bank of matched filters are determined as follows. The robust time domain template is assumed to take the form w(t)=A(t)cos[l brace]2[phi](t)[r brace]. Since the instantaneous frequency f(t) is known to be equal to the derivative of the phase [phi](t), the trajectory of a joint time-frequency representation of x(t) is used as an approximation of [phi][prime](t). 10 figs.

  6. Outage performance of cognitive radio systems with Improper Gaussian signaling

    KAUST Repository

    Amin, Osama

    2015-06-14

    Improper Gaussian signaling has proved its ability to improve the achievable rate of the systems that suffer from interference compared with proper Gaussian signaling. In this paper, we first study impact of improper Gaussian signaling on the performance of the cognitive radio system by analyzing the outage probability of both the primary user (PU) and the secondary user (SU). We derive exact expression of the SU outage probability and upper and lower bounds for the PU outage probability. Then, we design the SU signal by adjusting its transmitted power and the circularity coefficient to minimize the SU outage probability while maintaining a certain PU quality-of-service. Finally, we evaluate the proposed bounds and adaptive algorithms by numerical results.

  7. OPNET simulation Signaling System No.7 (SS7) network interfaces

    OpenAIRE

    Ow, Kong Chung.

    2000-01-01

    This thesis presents an OPNET model and simulation of the Signaling System No.7 (SS7) network, which is dubbed the world's largest data communications network. The main focus of the study is to model one of its levels, the Message Transfer Part Level 3, in accordance with the ITU.T recommendation Q.704. An overview of SS7 that includes the evolution and basics of SS7 architecture is provided to familarize the reader with the topic. This includes the protocol stack, signaling points, signaling...

  8. The ecology and evolution of avian alarm call signaling systems

    Science.gov (United States)

    Billings, Alexis Chandon

    Communication is often set up as a simple dyadic exchange between one sender and one receiver. However, in reality, signaling systems have evolved and are used with many forms and types of information bombarding multiple senders, who in turn send multiple signals of different modalities, through various environmental spaces, finally reaching multiple receivers. In order to understand both the ecology and evolution of a signaling system, we must examine all the facets of the signaling system. My dissertation focused on the alarm call signaling system in birds. Alarm calls are acoustic signals given in response to danger or predators. My first two chapters examine how information about predators alters alarm calls. In chapter one I found that chickadees make distinctions between predators of different hunting strategies and appear to encode information about predators differently if they are heard instead of seen. In my second chapter, I test these findings more robustly in a non-model bird, the Steller's jay. I again found that predator species matters, but that how Steller's jays respond if they saw or heard the predator depends on the predator species. In my third chapter, I tested how habitat has influenced the evolution of mobbing call acoustic structure. I found that habitat is not a major contributor to the variation in acoustic structure seen across species and that other selective pressures such as body size may be more important. In my fourth chapter I present a new framework to understand the evolution of multimodal communication across species. I identify a unique constraint, the need for overlapping sensory systems, thresholds and cognitive abilities between sender and receiver in order for different forms of interspecific communication to evolve. Taken together, these chapters attempt to understand a signaling system from both an ecological and evolutionary perspective by examining each piece of the communication scheme.

  9. Signal Processing Device (SPD) for networked radiation monitoring system

    International Nuclear Information System (INIS)

    Dharmapurikar, A.; Bhattacharya, S.; Mukhopadhyay, P.K.; Sawhney, A.; Patil, R.K.

    2010-01-01

    A networked radiation and parameter monitoring system with three tier architecture is being developed. Signal Processing Device (SPD) is a second level sub-system node in the network. SPD is an embedded system which has multiple input channels and output communication interfaces. It acquires and processes data from first level parametric sensor devices, and sends to third level devices in response to request commands received from host. It also performs scheduled diagnostic operations and passes on the information to host. It supports inputs in the form of differential digital signals and analog voltage signals. SPD communicates with higher level devices over RS232/RS422/USB channels. The system has been designed with main requirements of minimal power consumption and harsh environment in radioactive plants. This paper discusses the hardware and software design details of SPD. (author)

  10. Improper Signaling for Virtual Full-Duplex Relay Systems

    KAUST Repository

    Gaafar, Mohamed

    2017-02-14

    Virtual full-duplex (VFD) is a powerful solution to compensate the rate loss of half-duplex relaying without the need to full-duplex capable nodes. Inter-relay interference (IRI) challenges the operation of VFD relaying systems. Recently, improper signaling is employed at both relays of the VFD to mitigate the IRI by imposing the same signal characteristics for both relays. To further boost the achievable rate performance, asymmetric time sharing VFD relaying system is adopted with different improper signals at the half-duplex relays. The joint tuning of the three design parameters improves the achievable rate performance at different ranges of IRI and different relays locations. Extensive simulation results are presented and analyzed to show the achievable rate gain of the proposed system and understand the system behavior.

  11. Improper Signaling for Virtual Full-Duplex Relay Systems

    KAUST Repository

    Gaafar, Mohamed; Amin, Osama; Schaefer, Rafael F.; Alouini, Mohamed-Slim

    2017-01-01

    Virtual full-duplex (VFD) is a powerful solution to compensate the rate loss of half-duplex relaying without the need to full-duplex capable nodes. Inter-relay interference (IRI) challenges the operation of VFD relaying systems. Recently, improper signaling is employed at both relays of the VFD to mitigate the IRI by imposing the same signal characteristics for both relays. To further boost the achievable rate performance, asymmetric time sharing VFD relaying system is adopted with different improper signals at the half-duplex relays. The joint tuning of the three design parameters improves the achievable rate performance at different ranges of IRI and different relays locations. Extensive simulation results are presented and analyzed to show the achievable rate gain of the proposed system and understand the system behavior.

  12. Digital Signal Processor System for AC Power Drivers

    Directory of Open Access Journals (Sweden)

    Ovidiu Neamtu

    2009-10-01

    Full Text Available DSP (Digital Signal Processor is the bestsolution for motor control systems to make possible thedevelopment of advanced motor drive systems. The motorcontrol processor calculates the required motor windingvoltage magnitude and frequency to operate the motor atthe desired speed. A PWM (Pulse Width Modulationcircuit controls the on and off duty cycle of the powerinverter switches to vary the magnitude of the motorvoltages.

  13. High-speed railway signal trackside equipment patrol inspection system

    Science.gov (United States)

    Wu, Nan

    2018-03-01

    High-speed railway signal trackside equipment patrol inspection system comprehensively applies TDI (time delay integration), high-speed and highly responsive CMOS architecture, low illumination photosensitive technique, image data compression technique, machine vision technique and so on, installed on high-speed railway inspection train, and achieves the collection, management and analysis of the images of signal trackside equipment appearance while the train is running. The system will automatically filter out the signal trackside equipment images from a large number of the background image, and identify of the equipment changes by comparing the original image data. Combining with ledger data and train location information, the system accurately locate the trackside equipment, conscientiously guiding maintenance.

  14. A digital signal processing system for coherent laser radar

    Science.gov (United States)

    Hampton, Diana M.; Jones, William D.; Rothermel, Jeffry

    1991-01-01

    A data processing system for use with continuous-wave lidar is described in terms of its configuration and performance during the second survey mission of NASA'a Global Backscatter Experiment. The system is designed to estimate a complete lidar spectrum in real time, record the data from two lidars, and monitor variables related to the lidar operating environment. The PC-based system includes a transient capture board, a digital-signal processing (DSP) board, and a low-speed data-acquisition board. Both unprocessed and processed lidar spectrum data are monitored in real time, and the results are compared to those of a previous non-DSP-based system. Because the DSP-based system is digital it is slower than the surface-acoustic-wave signal processor and collects 2500 spectra/s. However, the DSP-based system provides complete data sets at two wavelengths from the continuous-wave lidars.

  15. Methods and systems for the processing of physiological signals

    International Nuclear Information System (INIS)

    Cosnac, B. de; Gariod, R.; Max, J.; Monge, V.

    1975-01-01

    This note is a general survey of the processing of physiological signals. After an introduction about electrodes and their limitations, the physiological nature of the main signals are shortly recalled. Different methods (signal averaging, spectral analysis, shape morphological analysis) are described as applications to the fields of magnetocardiography, electro-encephalography, cardiography, electronystagmography. As for processing means (single portable instruments and programmable), they are described through the example of application to rheography and to the Plurimat'S general system. As a conclusion the methods of signal processing are dominated by the morphological analysis of curves and by the necessity of a more important introduction of the statistical classification. As for the instruments, microprocessors will appear but specific operators linked to computer will certainly grow [fr

  16. 1st International Conference on Signal, Networks, Computing, and Systems

    CERN Document Server

    Mohapatra, Durga; Nagar, Atulya; Sahoo, Manmath

    2016-01-01

    The book is a collection of high-quality peer-reviewed research papers presented in the first International Conference on Signal, Networks, Computing, and Systems (ICSNCS 2016) held at Jawaharlal Nehru University, New Delhi, India during February 25–27, 2016. The book is organized in to two volumes and primarily focuses on theory and applications in the broad areas of communication technology, computer science and information security. The book aims to bring together the latest scientific research works of academic scientists, professors, research scholars and students in the areas of signal, networks, computing and systems detailing the practical challenges encountered and the solutions adopted.

  17. Wearable System for Acquisition and Monitoring of Biological Signals

    Science.gov (United States)

    Piccinini, D. J.; Andino, N. B.; Ponce, S. D.; Roberti, MA; López, y. N.

    2016-04-01

    This paper presents a modular, wearable system for acquisition and wireless transmission of biological signals. Configurable slaves for different signals (such as ECG, EMG, inertial sensors, and temperature) based in the ADS1294 Medical Analog Front End are connected to a Master, based in the CC3200 microcontroller, both from Texas Instruments. The slaves are configurable according to the specific application, providing versatility to the wearable system. The battery consumption is reduced, through a couple of Li-ion batteries and the circuit has also a battery charger. A custom made box was designed and fabricated in a 3D printer, preserving the requirements of low cost, low weight and safety recommendations.

  18. Signal Adaptive System for Space/Spatial-Frequency Analysis

    Directory of Open Access Journals (Sweden)

    Veselin N. Ivanović

    2009-01-01

    Full Text Available This paper outlines the development of a multiple-clock-cycle implementation (MCI of a signal adaptive two-dimensional (2D system for space/spatial-frequency (S/SF signal analysis. The design is based on a method for improved S/SF representation of the analyzed 2D signals, also proposed here. The proposed MCI design optimizes critical design performances related to hardware complexity, making it a suitable system for real time implementation on an integrated chip. Additionally, the design allows the implemented system to take a variable number of clock cycles (CLKs (the only necessary ones regarding desirable—2D Wigner distribution-presentation of autoterms in different frequency-frequency points during the execution. This ability represents a major advantage of the proposed design which helps to optimize the time required for execution and produce an improved, cross-terms-free S/SF signal representation. The design has been verified by a field-programmable gate array (FPGA circuit design, capable of performing S/SF analysis of 2D signals in real time.

  19. Phosphoproteomics-based systems analysis of signal transduction networks

    Directory of Open Access Journals (Sweden)

    Hiroko eKozuka-Hata

    2012-01-01

    Full Text Available Signal transduction systems coordinate complex cellular information to regulate biological events such as cell proliferation and differentiation. Although the accumulating evidence on widespread association of signaling molecules has revealed essential contribution of phosphorylation-dependent interaction networks to cellular regulation, their dynamic behavior is mostly yet to be analyzed. Recent technological advances regarding mass spectrometry-based quantitative proteomics have enabled us to describe the comprehensive status of phosphorylated molecules in a time-resolved manner. Computational analyses based on the phosphoproteome dynamics accelerate generation of novel methodologies for mathematical analysis of cellular signaling. Phosphoproteomics-based numerical modeling can be used to evaluate regulatory network elements from a statistical point of view. Integration with transcriptome dynamics also uncovers regulatory hubs at the transcriptional level. These omics-based computational methodologies, which have firstly been applied to representative signaling systems such as the epidermal growth factor receptor pathway, have now opened up a gate for systems analysis of signaling networks involved in immune response and cancer.

  20. Asymmetry in Signal Oscillations Contributes to Efficiency of Periodic Systems.

    Science.gov (United States)

    Bae, Seul-A; Acevedo, Alison; Androulakis, Ioannis P

    2016-01-01

    Oscillations are an important feature of cellular signaling that result from complex combinations of positive- and negative-feedback loops. The encoding and decoding mechanisms of oscillations based on amplitude and frequency have been extensively discussed in the literature in the context of intercellular and intracellular signaling. However, the fundamental questions of whether and how oscillatory signals offer any competitive advantages-and, if so, what-have not been fully answered. We investigated established oscillatory mechanisms and designed a study to analyze the oscillatory characteristics of signaling molecules and system output in an effort to answer these questions. Two classic oscillators, Goodwin and PER, were selected as the model systems, and corresponding no-feedback models were created for each oscillator to discover the advantage of oscillating signals. Through simulating the original oscillators and the matching no-feedback models, we show that oscillating systems have the capability to achieve better resource-to-output efficiency, and we identify oscillatory characteristics that lead to improved efficiency.

  1. The Use of Grafting to Study Systemic Signaling in Plants.

    Science.gov (United States)

    Tsutsui, Hiroki; Notaguchi, Michitaka

    2017-08-01

    Grafting has long been an important technique in agriculture. Nowadays, grafting is a widely used technique also to study systemic long-distance signaling in plants. Plants respond to their surrounding environment, and at that time many aspects of their physiology are regulated systemically; these start from local input signals and are followed by the transmission of information to the rest of the plant. For example, soil nutrient conditions, light/photoperiod, and biotic and abiotic stresses affect plants heterogeneously, and plants perceive such information in specific plant tissues or organs. Such environmental cues are crucial determinants of plant growth and development, and plants drastically change their morphology and physiology to adapt to various events in their life. Hitherto, intensive studies have been conducted to understand systemic signaling in plants, and grafting techniques have permitted advances in this field. The breakthrough technique of micrografting in Arabidopsis thaliana was established in 2002 and led to the development of molecular genetic tools in this field. Thereafter, various phenomena of systemic signaling have been identified at the molecular level, including nutrient fixation, flowering, circadian clock and defense against pathogens. The significance of grafting is that it can clarify the transmission of the stimulus and molecules. At present, many micro- and macromolecules have been identified as mobile signals, which are transported through plant vascular tissues to co-ordinate their physiology and development. In this review, we introduce the various grafting techniques that have been developed, we report on the recent advances in the field of plant systemic signaling where grafting techniques have been applied and provide insights for the future. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  2. Autonomous data acquisition system for Paks NPP process noise signals

    International Nuclear Information System (INIS)

    Lipcsei, S.; Kiss, S.; Czibok, T.; Dezso, Z.; Horvath, Cs.

    2005-01-01

    A prototype of a new concept noise diagnostics data acquisition system has been developed recently to renew the aged present system. This new system is capable of collecting the whole available noise signal set simultaneously. Signal plugging and data acquisition are performed by autonomous systems (installed at each reactor unit) that are controlled through the standard plant network from a central computer installed at a suitable location. Experts can use this central unit to process and archive data series downloaded from the reactor units. This central unit also provides selected noise diagnostics information for other departments. The paper describes the hardware and software architecture of the new system in detail, emphasising the potential benefits of the new approach. (author)

  3. Digital Signal Processing for In-Vehicle Systems and Safety

    CERN Document Server

    Boyraz, Pinar; Takeda, Kazuya; Abut, Hüseyin

    2012-01-01

    Compiled from papers of the 4th Biennial Workshop on DSP (Digital Signal Processing) for In-Vehicle Systems and Safety this edited collection features world-class experts from diverse fields focusing on integrating smart in-vehicle systems with human factors to enhance safety in automobiles. Digital Signal Processing for In-Vehicle Systems and Safety presents new approaches on how to reduce driver inattention and prevent road accidents. The material addresses DSP technologies in adaptive automobiles, in-vehicle dialogue systems, human machine interfaces, video and audio processing, and in-vehicle speech systems. The volume also features: Recent advances in Smart-Car technology – vehicles that take into account and conform to the driver Driver-vehicle interfaces that take into account the driving task and cognitive load of the driver Best practices for In-Vehicle Corpus Development and distribution Information on multi-sensor analysis and fusion techniques for robust driver monitoring and driver recognition ...

  4. Early warning signal for interior crises in excitable systems.

    Science.gov (United States)

    Karnatak, Rajat; Kantz, Holger; Bialonski, Stephan

    2017-10-01

    The ability to reliably predict critical transitions in dynamical systems is a long-standing goal of diverse scientific communities. Previous work focused on early warning signals related to local bifurcations (critical slowing down) and nonbifurcation-type transitions. We extend this toolbox and report on a characteristic scaling behavior (critical attractor growth) which is indicative of an impending global bifurcation, an interior crisis in excitable systems. We demonstrate our early warning signal in a conceptual climate model as well as in a model of coupled neurons known to exhibit extreme events. We observed critical attractor growth prior to interior crises of chaotic as well as strange-nonchaotic attractors. These observations promise to extend the classes of transitions that can be predicted via early warning signals.

  5. Reliability analysis for Atucha II reactor protection system signals

    International Nuclear Information System (INIS)

    Roca, Jose Luis

    1996-01-01

    Atucha II is a 745 MW Argentine Power Nuclear Reactor constructed by ENACE SA, Nuclear Argentine Company for Electrical Power Generation and SIEMENS AG KWU, Erlangen, Germany. A preliminary modular logic analysis of RPS (Reactor Protection System) signals was performed by means of the well known Swedish professional risk and reliability software named Risk-Spectrum taking as a basis a reference signal coded as JR17ER003 which command the two moderator loops valves. From the reliability and behavior knowledge for this reference signal follows an estimation of the reliability for the other 97 RPS signals. Because the preliminary character of this analysis Main Important Measures are not performed at this stage. Reliability is by the statistic value named unavailability predicted. The scope of this analysis is restricted from the measurement elements to the RPS buffer outputs. In the present context only one redundancy is analyzed so in the Instrumentation and Control area there no CCF (Common Cause Failures) present for signals. Finally those unavailability values could be introduced in the failure domain for the posterior complete Atucha II reliability analysis which includes all mechanical and electromechanical features. Also an estimation of the spurious frequency of RPS signals defined as faulty by no trip is performed

  6. Reliability analysis for Atucha II reactor protection system signals

    International Nuclear Information System (INIS)

    Roca, Jose L.

    2000-01-01

    Atucha II is a 745 MW Argentine power nuclear reactor constructed by Nuclear Argentine Company for Electric Power Generation S.A. (ENACE S.A.) and SIEMENS AG KWU, Erlangen, Germany. A preliminary modular logic analysis of RPS (Reactor Protection System) signals was performed by means of the well known Swedish professional risk and reliability software named Risk-Spectrum taking as a basis a reference signal coded as JR17ER003 which command the two moderator loops valves. From the reliability and behavior knowledge for this reference signal follows an estimation of the reliability for the other 97 RPS signals. Because the preliminary character of this analysis Main Important Measures are not performed at this stage. Reliability is by the statistic value named unavailability predicted. The scope of this analysis is restricted from the measurement elements to the RPS buffer outputs. In the present context only one redundancy is analyzed so in the Instrumentation and Control area there no CCF (Common Cause Failures) present for signals. Finally those unavailability values could be introduced in the failure domain for the posterior complete Atucha II reliability analysis which includes all mechanical and electromechanical features. Also an estimation of the spurious frequency of RPS signals defined as faulty by no trip is performed. (author)

  7. An enzymatic signal amplification system for calorimetric studies of cellobiohydrolases

    DEFF Research Database (Denmark)

    Murphy, Leigh; Baumann, Martin Johannes; Borch, Kim

    2010-01-01

    amplification method has been developed to measure even slow hydrolytically active enzymes such as cellobiohydrolases. This method is explained in detail for the amplification of the heat signal by more than 130 times by using glucose oxidase and catalase. The kinetics of this complex coupled reaction system...

  8. Advanced biofeedback from surface electromyography signals using fuzzy system

    DEFF Research Database (Denmark)

    Samani, Afshin; Holtermann, Andreas; Søgaard, Karen

    2010-01-01

    The aims of this study were to develop a fuzzy inference-based biofeedback system and investigate its effects when inducing active (shoulder elevation) and passive (relax) pauses on the trapezius muscle electromyographic (EMG) activity during computer work. Surface EMG signals were recorded from...

  9. Digital Signal Processing for Optical Coherent Communication Systems

    DEFF Research Database (Denmark)

    Zhang, Xu

    spectrum narrowing tolerance 112-Gb/s DP-QPSK optical coherent systems using digital adaptive equalizer. The demonstrated results show that off-line DSP algorithms are able to reduce the bit error rate (BER) penalty induced by signal spectrum narrowing. Third, we also investigate bi...... wavelength division multiplex (U-DWDM) optical coherent systems based on 10-Gbaud QPSK. We report U-DWDM 1.2-Tb/s QPSK coherent system achieving spectral efficiency of 4.0-bit/s/Hz. In the experimental demonstration, digital decision feed back equalizer (DFE) algorithms and a finite impulse response (FIR......In this thesis, digital signal processing (DSP) algorithms are studied to compensate for physical layer impairments in optical fiber coherent communication systems. The physical layer impairments investigated in this thesis include optical fiber chromatic dispersion, polarization demultiplexing...

  10. Master Clock and Time-Signal-Distribution System

    Science.gov (United States)

    Tjoelker, Robert; Calhoun, Malcolm; Kuhnle, Paul; Sydnor, Richard; Lauf, John

    2007-01-01

    A timing system comprising an electronic master clock and a subsystem for distributing time signals from the master clock to end users is undergoing development to satisfy anticipated timing requirements of NASA s Deep Space Network (DSN) for the next 20 to 30 years. This system has a modular, flexible, expandable architecture that is easier to operate and maintain than the present frequency and timing subsystem (FTS).

  11. Coding and signal processing for magnetic recording systems

    CERN Document Server

    Vasic, Bane

    2004-01-01

    RECORDING SYSTEMSA BriefHistory of Magnetic Storage, Dean PalmerPhysics of Longitudinal and Perpendicular Recording, Hong Zhou, Tom Roscamp, Roy Gustafson, Eric Boernern, and Roy ChantrellThe Physics of Optical Recording, William A. Challener and Terry W. McDanielHead Design Techniques for Recording Devices, Robert E. RottmayerCOMMUNICATION AND INFORMATION THEORY OF MAGNETIC RECORDING CHANNELSModeling the Recording Channel, Jaekyun MoonSignal and Noise Generation for Magnetic Recording Channel Simulations, Xueshi Yang and Erozan M. KurtasStatistical Analysis of Digital Signals and Systems, Dra

  12. Power and signal transmission for mobile teleoperated systems

    International Nuclear Information System (INIS)

    Morris, A.C. Jr.; Hamel, W.R.

    1986-01-01

    Appropriate means must be furnished for supplying power and for sending controlling commands to mobile teleoperated systems. This paper describes a number of umbilical, onboard, and wireless systems used in transmitting power that are available for mobile teleoperator services. The pros and cons of selecting appropriate methods from a list of possible communication systems (wired, fiber optic, and radio frequency) are also examined. Moreover, hybrid systems combining wireless power transmissions with command-information signals are also possible. 20 refs., 6 figs., 1 tab

  13. Roles of Zinc Signaling in the Immune System.

    Science.gov (United States)

    Hojyo, Shintaro; Fukada, Toshiyuki

    2016-01-01

    Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth, differentiation, and survival. Zn deficiency depresses both innate and adaptive immune responses. However, the precise physiological mechanisms of the Zn-mediated regulation of the immune system have been largely unclear. Zn homeostasis is tightly controlled by the coordinated activity of Zn transporters and metallothioneins, which regulate the transport, distribution, and storage of Zn. There is growing evidence that Zn behaves like a signaling molecule, facilitating the transduction of a variety of signaling cascades in response to extracellular stimuli. In this review, we highlight the emerging functional roles of Zn and Zn transporters in immunity, focusing on how crosstalk between Zn and immune-related signaling guides the normal development and function of immune cells.

  14. Impact of Improper Gaussian Signaling on Hardware Impaired Systems

    KAUST Repository

    Javed, Sidrah; Amin, Osama; Ikki, Salam S.; Alouini, Mohamed-Slim

    2016-01-01

    In this paper, we accurately model the hardware impairments (HWI) as improper Gaussian signaling (IGS) which can characterize the asymmetric characteristics of different HWI sources. The proposed model encourages us to adopt IGS scheme for transmitted signal that represents a general study compared with the conventional scheme, proper Gaussian signaling (PGS). First, we express the achievable rate of HWI systems when both PGS and IGS schemes are used when the aggregate effect of HWI is modeled as IGS. Moreover, we tune the IGS statistical characteristics to maximize the achievable rate. Then, we analyze the outage probability for both schemes and derive closed form expressions. Finally, we validate the analytic expressions through numerical and simulation results. In addition, we quantify through the numerical results the performance degradation in the absence of ideal transceivers and the gain reaped from adopting IGS scheme compared with PGS scheme.

  15. Impact of Improper Gaussian Signaling on Hardware Impaired Systems

    KAUST Repository

    Javed, Sidrah

    2016-12-18

    In this paper, we accurately model the hardware impairments (HWI) as improper Gaussian signaling (IGS) which can characterize the asymmetric characteristics of different HWI sources. The proposed model encourages us to adopt IGS scheme for transmitted signal that represents a general study compared with the conventional scheme, proper Gaussian signaling (PGS). First, we express the achievable rate of HWI systems when both PGS and IGS schemes are used when the aggregate effect of HWI is modeled as IGS. Moreover, we tune the IGS statistical characteristics to maximize the achievable rate. Then, we analyze the outage probability for both schemes and derive closed form expressions. Finally, we validate the analytic expressions through numerical and simulation results. In addition, we quantify through the numerical results the performance degradation in the absence of ideal transceivers and the gain reaped from adopting IGS scheme compared with PGS scheme.

  16. Web monitoring of industrial signals using embedded systems

    Directory of Open Access Journals (Sweden)

    Cesar Augusto Romero-Molano

    2016-01-01

    Full Text Available The paper presents the design of software and hardware for a system of web monitoring of industrial signals. This prototype provides a web interface which can observe in real time the status of four industrial-type signal on-off. MSP432 microcontroller is used for sampling and transmitting monitored signals to a Raspberry PI which receives by a UART link the MSP432 monitored data and presents them immediately in the front-end web application. The prototype design was verified with a pneumatic application that consists of four single-acting cylinders and it was observed an efficient synchronization between the occurrence of the triggering event or change in status of any of the monitored cylinder and web publishing.

  17. A Segmented Signal Progression Model for the Modern Streetcar System

    Directory of Open Access Journals (Sweden)

    Baojie Wang

    2015-01-01

    Full Text Available This paper is on the purpose of developing a segmented signal progression model for modern streetcar system. The new method is presented with the following features: (1 the control concept is based on the assumption of only one streetcar line operating along an arterial under a constant headway and no bandwidth demand for streetcar system signal progression; (2 the control unit is defined as a coordinated intersection group associated with several streetcar stations, and the control joints must be streetcar stations; (3 the objective function is built to ensure the two-way streetcar arrival times distributing within the available time of streetcar phase; (4 the available time of streetcar phase is determined by timing schemes, intersection structures, track locations, streetcar speeds, and vehicular accelerations; (5 the streetcar running speed is constant separately whether it is in upstream or downstream route; (6 the streetcar dwell time is preset according to historical data distribution or charging demand. The proposed method is experimentally examined in Hexi New City Streetcar Project in Nanjing, China. In the experimental results, the streetcar system operation and the progression impacts are shown to affect transit and vehicular traffic. The proposed model presents promising outcomes through the design of streetcar system segmented signal progression, in terms of ensuring high streetcar system efficiency and minimizing negative impacts on transit and vehicular traffic.

  18. New Radiofrequency Exposure System with Real Telecommunication Signals

    Directory of Open Access Journals (Sweden)

    Jakub Misek

    2018-01-01

    Full Text Available In recent years, there has been an increase in the number of studies on biological effects of Electromagnetic (EM fields emitted from Base Transceiver Stations (BTSs. The biological effects of generated and real telecommunication signals produced by different types of exposure systems are discussed. However, the proper exposure methods for such experiments are very limited. We successfully developed a simple and cost-effective exposure unit with real GSM/DCS/UMTS signal from BTS containing proper modulations or intermittence (continuous, interrupted. Signal processing and conditioning unit is based on a Radiofrequency (RF repeater. The downlink signal is filtered by integrated high selectivity passband filters and amplified to a required level. The main part of exposure unit is a Faraday cage with the specimen (exposure area measuring 150 x 250 mm with E-field percent deviation less than 18%. This exposure system can be helpful in experiments with living organisms in in vivo studies and in vitro studies with normal or pathological cells and other micro scale structures being exposed to RF EM fields from BTS.

  19. JACoW Lightweight acquisition system for analogue signals

    CERN Document Server

    Bielawski, Bartosz

    2018-01-01

    In a complex machine such as a particle accelerator there are thousands of analogue signals that need monitoring and even more signals that could be used for debugging or as a tool for detecting symptoms of potentially avoidable problems. Usually it is not feasible to acquire and monitor all of these signals not only because of the cost but also because of cabling and space required. The Radio Frequency system in the Large Hadron Collider (LHC) is protected by multiple hardware interlocks that ensure safe operation of klystrons, superconducting cavities and all the other equipment. In parallel, a diagnostic system has been deployed to monitor the health of the klystrons. Due to the limited amount of space and the moderate number of signals to be monitored, a standard approach with a full VME or Compact PCI crate has not been selected. Instead, small embedded industrial computers with Universal Serial Bus (USB) oscilloscopes chosen for the specific application have been installed. This cost effective, rapidly ...

  20. Development of an expert system for signal validation

    International Nuclear Information System (INIS)

    Qualls, A.L.; Uhrig, R.E.; Upadhyaya, B.R.

    1988-01-01

    Diagnosis of malfunctions in power plants has traditionally been in the domain of the process operator, who relies on training, experience, and reasoning ability to diagnose faults. The authors describe a method of signal validation using expert system technology, which detects possible anomalies in an instrument channel's output, similar to the procedure used by an operator. The system can be used to scan quickly over an array of sensor outputs and flag those that are observed to have possible anomalies. This system, when implemented in an operating power plant, could be used for continuous, on-line instrument anomaly detection with a minimum of computational effort

  1. Chaos based encryption system for encrypting electroencephalogram signals.

    Science.gov (United States)

    Lin, Chin-Feng; Shih, Shun-Han; Zhu, Jin-De

    2014-05-01

    In the paper, we use the Microsoft Visual Studio Development Kit and C# programming language to implement a chaos-based electroencephalogram (EEG) encryption system involving three encryption levels. A chaos logic map, initial value, and bifurcation parameter for the map were used to generate Level I chaos-based EEG encryption bit streams. Two encryption-level parameters were added to these elements to generate Level II chaos-based EEG encryption bit streams. An additional chaotic map and chaotic address index assignment process was used to implement the Level III chaos-based EEG encryption system. Eight 16-channel EEG Vue signals were tested using the encryption system. The encryption was the most rapid and robust in the Level III system. The test yielded superior encryption results, and when the correct deciphering parameter was applied, the EEG signals were completely recovered. However, an input parameter error (e.g., a 0.00001 % initial point error) causes chaotic encryption bit streams, preventing the recovery of 16-channel EEG Vue signals.

  2. Degradation signals for ubiquitin system proteolysis in Saccharomyces cerevisiae.

    Science.gov (United States)

    Gilon, T; Chomsky, O; Kulka, R G

    1998-01-01

    Combinations of different ubiquitin-conjugating (Ubc) enzymes and other factors constitute subsidiary pathways of the ubiquitin system, each of which ubiquitinates a specific subset of proteins. There is evidence that certain sequence elements or structural motifs of target proteins are degradation signals which mark them for ubiquitination by a particular branch of the ubiquitin system and for subsequent degradation. Our aim was to devise a way of searching systematically for degradation signals and to determine to which ubiquitin system subpathways they direct the proteins. We have constructed two reporter gene libraries based on the lacZ or URA3 genes which, in Saccharomyces cerevisiae, express fusion proteins with a wide variety of C-terminal extensions. From these, we have isolated clones producing unstable fusion proteins which are stabilized in various ubc mutants. Among these are 10 clones whose products are stabilized in ubc6, ubc7 or ubc6ubc7 double mutants. The C-terminal extensions of these clones, which vary in length from 16 to 50 amino acid residues, are presumed to contain degradation signals channeling proteins for degradation via the UBC6 and/or UBC7 subpathways of the ubiquitin system. Some of these C-terminal tails share similar sequence motifs, and a feature common to almost all of these sequences is a highly hydrophobic region such as is usually located inside globular proteins or inserted into membranes. PMID:9582269

  3. Long-distance digital signal transfers between trigger system and TOF system of BES III

    International Nuclear Information System (INIS)

    Liu Guangdong; Liu Shubin; An Qi

    2007-01-01

    This article introduces a design of digital signals communication between the trigger system and the TOF system of BES III. The design can support the BES III successfully, which is based on fiber digital communication, FPGA etc. (authors)

  4. Hybrid soft computing systems for electromyographic signals analysis: a review

    Science.gov (United States)

    2014-01-01

    Electromyographic (EMG) is a bio-signal collected on human skeletal muscle. Analysis of EMG signals has been widely used to detect human movement intent, control various human-machine interfaces, diagnose neuromuscular diseases, and model neuromusculoskeletal system. With the advances of artificial intelligence and soft computing, many sophisticated techniques have been proposed for such purpose. Hybrid soft computing system (HSCS), the integration of these different techniques, aims to further improve the effectiveness, efficiency, and accuracy of EMG analysis. This paper reviews and compares key combinations of neural network, support vector machine, fuzzy logic, evolutionary computing, and swarm intelligence for EMG analysis. Our suggestions on the possible future development of HSCS in EMG analysis are also given in terms of basic soft computing techniques, further combination of these techniques, and their other applications in EMG analysis. PMID:24490979

  5. Snore related signals processing in a private cloud computing system.

    Science.gov (United States)

    Qian, Kun; Guo, Jian; Xu, Huijie; Zhu, Zhaomeng; Zhang, Gongxuan

    2014-09-01

    Snore related signals (SRS) have been demonstrated to carry important information about the obstruction site and degree in the upper airway of Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) patients in recent years. To make this acoustic signal analysis method more accurate and robust, big SRS data processing is inevitable. As an emerging concept and technology, cloud computing has motivated numerous researchers and engineers to exploit applications both in academic and industry field, which could have an ability to implement a huge blue print in biomedical engineering. Considering the security and transferring requirement of biomedical data, we designed a system based on private cloud computing to process SRS. Then we set the comparable experiments of processing a 5-hour audio recording of an OSAHS patient by a personal computer, a server and a private cloud computing system to demonstrate the efficiency of the infrastructure we proposed.

  6. Hybrid soft computing systems for electromyographic signals analysis: a review.

    Science.gov (United States)

    Xie, Hong-Bo; Guo, Tianruo; Bai, Siwei; Dokos, Socrates

    2014-02-03

    Electromyographic (EMG) is a bio-signal collected on human skeletal muscle. Analysis of EMG signals has been widely used to detect human movement intent, control various human-machine interfaces, diagnose neuromuscular diseases, and model neuromusculoskeletal system. With the advances of artificial intelligence and soft computing, many sophisticated techniques have been proposed for such purpose. Hybrid soft computing system (HSCS), the integration of these different techniques, aims to further improve the effectiveness, efficiency, and accuracy of EMG analysis. This paper reviews and compares key combinations of neural network, support vector machine, fuzzy logic, evolutionary computing, and swarm intelligence for EMG analysis. Our suggestions on the possible future development of HSCS in EMG analysis are also given in terms of basic soft computing techniques, further combination of these techniques, and their other applications in EMG analysis.

  7. Develop advanced nonlinear signal analysis topographical mapping system

    Science.gov (United States)

    1994-01-01

    The Space Shuttle Main Engine (SSME) has been undergoing extensive flight certification and developmental testing, which involves some 250 health monitoring measurements. Under the severe temperature, pressure, and dynamic environments sustained during operation, numerous major component failures have occurred, resulting in extensive engine hardware damage and scheduling losses. To enhance SSME safety and reliability, detailed analysis and evaluation of the measurements signal are mandatory to assess its dynamic characteristics and operational condition. Efficient and reliable signal detection techniques will reduce catastrophic system failure risks and expedite the evaluation of both flight and ground test data, and thereby reduce launch turn-around time. The basic objective of this contract are threefold: (1) develop and validate a hierarchy of innovative signal analysis techniques for nonlinear and nonstationary time-frequency analysis. Performance evaluation will be carried out through detailed analysis of extensive SSME static firing and flight data. These techniques will be incorporated into a fully automated system; (2) develop an advanced nonlinear signal analysis topographical mapping system (ATMS) to generate a Compressed SSME TOPO Data Base (CSTDB). This ATMS system will convert tremendous amount of complex vibration signals from the entire SSME test history into a bank of succinct image-like patterns while retaining all respective phase information. High compression ratio can be achieved to allow minimal storage requirement, while providing fast signature retrieval, pattern comparison, and identification capabilities; and (3) integrate the nonlinear correlation techniques into the CSTDB data base with compatible TOPO input data format. Such integrated ATMS system will provide the large test archives necessary for quick signature comparison. This study will provide timely assessment of SSME component operational status, identify probable causes of

  8. Calcium efflux systems in stress signalling and adaptation in plants

    Directory of Open Access Journals (Sweden)

    Jayakumar eBose

    2011-12-01

    Full Text Available Transient cytosolic calcium ([Ca2+]cyt elevation is an ubiquitous denominator of the signalling network when plants are exposed to literally every known abiotic and biotic stress. These stress-induced [Ca2+]cyt elevations vary in magnitude, frequency and shape, depending on the severity of the stress as well the type of stress experienced. This creates a unique stress-specific calcium signature that is then decoded by signal transduction networks. While most published papers have been focused predominantly on the role of Ca2+ influx mechanisms in shaping [Ca2+]cyt signatures, restoration of the basal [Ca2+]cyt levels is impossible without both cytosolic Ca2+ buffering and efficient Ca2+ efflux mechanisms removing excess Ca2+ from cytosol, to reload Ca2+ stores and to terminate Ca2+ signalling. This is the topic of the current review. The molecular identity of two major types of Ca2+ efflux systems, Ca2+-ATPase pumps and Ca2+/H+ exchangers, is described, and their regulatory modes are analysed in detail. The spatial and temporal organisation of calcium signalling networks is described, and the importance of existence of intracellular calcium microdomains is discussed. Experimental evidence for the role of Ca2+ efflux systems in plant responses to a range of abiotic and biotic factors is summarised. Contribution of Ca2+-ATPase pumps and Ca2+/H+ exchangers in shaping [Ca2+]cyt signatures is then modelled by using a four-component model (plasma- and endo- membrane-based Ca2+-permeable channels and efflux systems taking into account the cytosolic Ca2+ buffering. It is concluded that physiologically relevant variations in the activity of Ca2+-ATPase pumps and Ca2+/H+ exchangers are sufficient to fully describe all the reported experimental evidence and determine the shape of [Ca2+]cyt signatures in response to environmental stimuli, emphasising the crucial role these active efflux systems play in plant adaptive responses to environment.

  9. Effects of in vivo exposure to UV filters (4-MBC, OMC, BP-3, 4-HB, OC, OD-PABA) on endocrine signaling genes in the insect Chironomus riparius.

    Science.gov (United States)

    Ozáez, Irene; Martínez-Guitarte, José Luis; Morcillo, Gloria

    2013-07-01

    There is increasing evidence indicating that several UV filters might have endocrine disruptive effects. Numerous studies have evaluated hormonal effects in vertebrates, mainly reporting estrogenic and androgenic activities in mammals and fishes. There is only limited knowledge about potential endocrine activity in invertebrate hormonal systems. In this work, the effects on endocrine signaling genes of six frequently used UV filters were investigated in Chironomus riparius, a reference organism in aquatic toxicology. The UV filters studied were: octyl-p-methoxycinnamate (OMC) also called 2-ethylhexyl-4-methoxycinnamate (EHMC); 4-methylbenzylidene camphor (4-MBC); benzophenone-3 (BP-3); 4-hidroxybenzophenone (4-HB); octocrylene (OC); and octyldimethyl-p-aminobenzoate (OD-PABA). After in vivo exposure at different dosages, expression levels of the genes coding for the ecdysone receptor (EcR), the ultraspiracle (usp, ortholog of the RXR) and the estrogen-related receptor (ERR) were quantified by Real Time PCR. The EcR gene was significantly upregulated by 4-MBC, OMC/EHMC and OD-PABA, with a dose-related response following 24h exposure. In contrast, the benzophenones, BP-3 and 4-HB, as well as OC did not alter this gene at the same exposure conditions. The transcription profiles of the usp and ERR genes were not significantly affected, except for BP-3 that inhibited the usp gene at the highest concentration. To our knowledge, this is the first experimental evidence in invertebrates of a direct effect of UV filters on endocrine-related genes, and is consistent with the known effects on vertebrate hormonal receptor genes. The capability of 4-MBC, OMC/EHMC and OD-PABA to stimulate the expression of the ecdysone receptor, a key transcription factor for the ecdysone-genomic response in arthropods, suggests the possibility of a broad and long-term effect on this hormonal pathway. These findings strengthen the need for further research about the ecotoxicological implications

  10. Design principles of paradoxical signaling in the immune system

    Science.gov (United States)

    Hart, Yuval

    A widespread feature of cell-cell signaling systems is paradoxical pleiotropy: the same secreted signaling molecule can induce opposite effects in the responding cells. For example, the cytokine IL-2 can promote proliferation and death of T-cells. The role of such paradoxical signaling remains unclear. We suggest that this mechanism provides homeostatic concentration of cells, independent of initial conditions. The crux of the paradoxical mechanism is the combination of a positive and a negative feedback loops creating two stable states - an OFF state and an ON state. Experimentally, we found that CD4 + cells grown in culture with a 30-fold difference in initial concentrations reached a homeostatic concentration nearly independent of initial cell levels (ON-state). Below an initial threshold, cell density decayed to extinction (OFF-state). Mathematical modeling explained the observed cell and cytokine dynamics and predicted conditions that shifted cell fate from homeostasis to the OFF-state. We suggest that paradoxical signaling provides cell circuits with specific dynamical features that are robust to environmental perturbations.

  11. Dangerous mating systems: signal complexity, signal content and neural capacity in spiders.

    Science.gov (United States)

    Herberstein, M E; Wignall, A E; Hebets, E A; Schneider, J M

    2014-10-01

    Spiders are highly efficient predators in possession of exquisite sensory capacities for ambushing prey, combined with machinery for launching rapid and determined attacks. As a consequence, any sexually motivated approach carries a risk of ending up as prey rather than as a mate. Sexual selection has shaped courtship to effectively communicate the presence, identity, motivation and/or quality of potential mates, which help ameliorate these risks. Spiders communicate this information via several sensory channels, including mechanical (e.g. vibrational), visual and/or chemical, with examples of multimodal signalling beginning to emerge in the literature. The diverse environments that spiders inhabit have further shaped courtship content and form. While our understanding of spider neurobiology remains in its infancy, recent studies are highlighting the unique and considerable capacities of spiders to process and respond to complex sexual signals. As a result, the dangerous mating systems of spiders are providing important insights into how ecology shapes the evolution of communication systems, with future work offering the potential to link this complex communication with its neural processes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Earthquake early warning system using real-time signal processing

    Energy Technology Data Exchange (ETDEWEB)

    Leach, R.R. Jr.; Dowla, F.U.

    1996-02-01

    An earthquake warning system has been developed to provide a time series profile from which vital parameters such as the time until strong shaking begins, the intensity of the shaking, and the duration of the shaking, can be derived. Interaction of different types of ground motion and changes in the elastic properties of geological media throughout the propagation path result in a highly nonlinear function. We use neural networks to model these nonlinearities and develop learning techniques for the analysis of temporal precursors occurring in the emerging earthquake seismic signal. The warning system is designed to analyze the first-arrival from the three components of an earthquake signal and instantaneously provide a profile of impending ground motion, in as little as 0.3 sec after first ground motion is felt at the sensors. For each new data sample, at a rate of 25 samples per second, the complete profile of the earthquake is updated. The profile consists of a magnitude-related estimate as well as an estimate of the envelope of the complete earthquake signal. The envelope provides estimates of damage parameters, such as time until peak ground acceleration (PGA) and duration. The neural network based system is trained using seismogram data from more than 400 earthquakes recorded in southern California. The system has been implemented in hardware using silicon accelerometers and a standard microprocessor. The proposed warning units can be used for site-specific applications, distributed networks, or to enhance existing distributed networks. By producing accurate, and informative warnings, the system has the potential to significantly minimize the hazards of catastrophic ground motion. Detailed system design and performance issues, including error measurement in a simple warning scenario are discussed in detail.

  13. Debuncher Momentum Cooling Systems Signal to Noise Measurements

    Energy Technology Data Exchange (ETDEWEB)

    Pasquinelli, Ralph J.; /Fermilab

    2001-12-18

    The Debuncher Momentum cooling systems were carefully measured for signal to noise. It was observed that cooling performance was not optimum. Closer inspection shows that the installed front-end bandpass filters are wider than the pickup response. (The original filters were specified to be wider so that none of the available bandwidth would be clipped.) The end result is excess noise is amplified and passed onto the kickers unimpeded, hence, reducing the achievable system gain. From this data, new filters should be designed to improve performance. New system bandwidths are specified on the data figures. Also included are the transfer function measurements that clearly show adjacent band response. In band 4 upper, the adjacent lobes are strong and out of phase. This is also degrading the system performance. The correlation between spectrum analyzer signal to noise and network analyzer system transfer functions is very strong. The table below has a calculation of expected improvement of front noise reduction by means of building new front-end bandpass filters. The calculation is based on a flat input noise spectrum and is a linear estimation of improvement. The listed 3dB bandwidths of the original filters are from measured data. The expected bandwidth is taken from the linear spectrum analyzer plots and is closer to a 10 dB bandwidth making the percentage improvement conservative. The signal to noise measurements are taken with circulating pbars in the Debuncher. One cooling system was measured at a time with all others off. Beam currents are below ten microamperes.

  14. FireSignal - Data Acquisition and Control System Software

    International Nuclear Information System (INIS)

    Neto, A.; Fernandes, H.; Duarte, A.; Carvalho, B.; Sousa, J.; Valcarcel, D.; Varandas, C.; Hron, M.

    2006-01-01

    Control of fusion devices requires good, non-ambiguous, easy to use user-interfaces to configure hardware devices. To solve this problem a highly generic system for data control and acquisition has been developed. Among the main features it allows remote hardware configuration, shot launching, data sharing between connected users and experiment monitoring. The system is fully distributed: the hardware driver nodes, clients and server are completely independent from each other and might be running in different operating systems and programmed in different languages. All the communication is provided through the Common Object Request Broker Architecture (CORBA) protocol. FireSignal was designed from the beginning to be as independent as possible from any kind of constraints as it's a plugin based system. Database, data viewers and the security system are some examples of what can easily be changed and adapted to the target machine's needs. All hardware is described in eXtendend Markup Language (XML) and from this information the FireSignal client application can build automatically Graphical User Interfaces (GUI) and validate the user's parameter configuration. Any type of hardware can be integrated in the system as long as it is described in XML and the respective driver is developed. Any modern programming language can be used to develop these drivers, and currently we use Python and Java generic drivers. All data storage and indexing is time stamped event-based s. Nodes are responsible for tagging the acquired samples with the absolute time stamps and to react to machine events. FireSignal is currently being used to control the ISTTOK/PT and CASTOR/CZ tokamaks. (author)

  15. Debuncher Momentum Cooling Systems Signal to Noise Measurements

    International Nuclear Information System (INIS)

    Pasquinelli, Ralph J.

    2001-01-01

    The Debuncher Momentum cooling systems were carefully measured for signal to noise. It was observed that cooling performance was not optimum. Closer inspection shows that the installed front-end bandpass filters are wider than the pickup response. (The original filters were specified to be wider so that none of the available bandwidth would be clipped.) The end result is excess noise is amplified and passed onto the kickers unimpeded, hence, reducing the achievable system gain. From this data, new filters should be designed to improve performance. New system bandwidths are specified on the data figures. Also included are the transfer function measurements that clearly show adjacent band response. In band 4 upper, the adjacent lobes are strong and out of phase. This is also degrading the system performance. The correlation between spectrum analyzer signal to noise and network analyzer system transfer functions is very strong. The table below has a calculation of expected improvement of front noise reduction by means of building new front-end bandpass filters. The calculation is based on a flat input noise spectrum and is a linear estimation of improvement. The listed 3dB bandwidths of the original filters are from measured data. The expected bandwidth is taken from the linear spectrum analyzer plots and is closer to a 10 dB bandwidth making the percentage improvement conservative. The signal to noise measurements are taken with circulating pbars in the Debuncher. One cooling system was measured at a time with all others off. Beam currents are below ten microamperes.

  16. Microcomputer-based real-time optical signal processing system

    Science.gov (United States)

    Yu, F. T. S.; Cao, M. F.; Ludman, J. E.

    1986-01-01

    A microcomputer-based real-time programmable optical signal processing system utilizing a Magneto-Optic Spatial Light Modulator (MOSLM) and a Liquid Crystal Light Valve (LCLV) is described. This system can perform a myriad of complicated optical operations, such as image correlation, image subtraction, matrix multiplication and many others. The important assets of this proposed system must be the programmability and the capability of real-time addressing. The design specification and the progress toward practical implementation of this proposed system are discussed. Some preliminary experimental demonstrations are conducted. The feasible applications of this proposed system to image correlation for optical pattern recognition, image subtraction for IC chip inspection and matrix multiplication for optical computing are demonstrated.

  17. Power and signal transmission for mobile teleoperated systems

    International Nuclear Information System (INIS)

    Morris, A.C. Jr.; Hamel, W.R.

    1985-01-01

    Appropriate means must be furnished for supplying power and for sending controlling commands to mobile teleoperated systems. Because a sizable number of possibilities are available for such applications, methods used in designing both the power and communications systems built into mobile vehicles that serve in radiological emergencies must be carefully selected. This paper describes a number of umbilical, on-board, and wireless systems used in tranmitting power that are available for mobile teleoperator services. The pros and cons of selecting appropriate methods from a list of possible communication systems (wired, fiber optic, and radio frequency) are also examined. Moreover, hybrid systems combining wireless power transmissions with command-information signals are also possible

  18. Redox Signaling Mediated by Thioredoxin and Glutathione Systems in the Central Nervous System.

    Science.gov (United States)

    Ren, Xiaoyuan; Zou, Lili; Zhang, Xu; Branco, Vasco; Wang, Jun; Carvalho, Cristina; Holmgren, Arne; Lu, Jun

    2017-11-01

    The thioredoxin (Trx) and glutathione (GSH) systems play important roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress due to its high-energy demand. These two disulfide reductase systems are active in various areas of the brain and are considered to be critical antioxidant systems in the central nervous system (CNS). Various neuronal disorders have been characterized to have imbalanced redox homeostasis. Recent Advances: In addition to their detrimental effects, recent studies have highlighted that reactive oxygen species/reactive nitrogen species (ROS/RNS) act as critical signaling molecules by modifying thiols in proteins. The Trx and GSH systems, which reversibly regulate thiol modifications, regulate redox signaling involved in various biological events in the CNS. In this review, we focus on the following: (i) how ROS/RNS are produced and mediate signaling in CNS; (ii) how Trx and GSH systems regulate redox signaling by catalyzing reversible thiol modifications; (iii) how dysfunction of the Trx and GSH systems causes alterations of cellular redox signaling in human neuronal diseases; and (iv) the effects of certain small molecules that target thiol-based signaling pathways in the CNS. Further study on the roles of thiol-dependent redox systems in the CNS will improve our understanding of the pathogenesis of many human neuronal disorders and also help to develop novel protective and therapeutic strategies against neuronal diseases. Antioxid. Redox Signal. 27, 989-1010.

  19. Development of an expert system for signal validation: Topical report

    International Nuclear Information System (INIS)

    Qualls, A.L.; Uhrig, R.E.; Upadhyaya, B.R.

    1988-07-01

    A signal validation and sensor information expert system is developed and applied to nuclear power plant subsystems. The expert system interactively provides the user with a list of sensors used to monitor a subsystem of a power plant and answers the user's questions about the characteristics of those sensors. The expert system performs an evaluation of the present output characteristics of an instrument channel. The evaluation is fully automated and is designed to mimic an operator's approach to signal validation. The evaluation is designed to detect three types of possible sensor anomalies: (1) incorrect average output, (2) improper noise level,and (3) incorrect response to a system perturbation. There are two tests used to detect each possible anomalous condition. One test is a comparison of the specified sensor characteristic against the same characteristic of its redundant sensors. The second test is a prediction of the sensor's expected behavior and comparison with its observed behavior. The evaluation was tested using operational data from twelve sensors used to monitor level, pressure, primary and secondary coolant flow rates, and hot and cold leg temperatures of a steam generator in a commercial nuclear power plant. The results of the testing demonstrated successfully that the evaluation detected the three possible anomalies, and was able to handle conflicting information using the comparison among redundant sensors and the system specific test used to detect the anomalies

  20. Development of an electronic system for signals amplification

    International Nuclear Information System (INIS)

    Santos, Italo S.; Tobias, Carmen C.B.

    2009-01-01

    This paper presents the obtained results with a spectrometer for electromagnetic radiation whose detector, a Si PIN type diode, was directly coupled to a signal amplification system developed in this project for scientific initiation. The linearity conditions and the gain operational limits, constituted of two stages of amplification based on the employment of devices from AMTEK A225 and A206, were determined using a precision pulse generator. The obtained results shown that the developed system is stable and linear in the gain range of 50-150. The spectrometric response of the electronic system coupled to the Siemens SFH-00206 type diode, were studied in view of the register of the 59.5 keV gamma ray spectra proceeding from 241 Am as function of the reversal polarization voltage. The influence pf the voltage and the electronic contribution in the energy resolution of the registered spectra under room temperature (22 degree Celsius) had also investigated considering the more adequate value of the coupling capacitance of the amplification system diode. Up to the present. the best energy resolution (FWHM = 4.85 keV) of the 59.5 keV line was obtained for the condition of the detector polarization at 16 V. This result proves that the signal amplification system developed coupled to the SFH00206 diode, besides the low cost, excellent operational condition for the detection and spectrometry or low energy electromagnetic radiation

  1. Nonlinear signal processing using neural networks: Prediction and system modelling

    Energy Technology Data Exchange (ETDEWEB)

    Lapedes, A.; Farber, R.

    1987-06-01

    The backpropagation learning algorithm for neural networks is developed into a formalism for nonlinear signal processing. We illustrate the method by selecting two common topics in signal processing, prediction and system modelling, and show that nonlinear applications can be handled extremely well by using neural networks. The formalism is a natural, nonlinear extension of the linear Least Mean Squares algorithm commonly used in adaptive signal processing. Simulations are presented that document the additional performance achieved by using nonlinear neural networks. First, we demonstrate that the formalism may be used to predict points in a highly chaotic time series with orders of magnitude increase in accuracy over conventional methods including the Linear Predictive Method and the Gabor-Volterra-Weiner Polynomial Method. Deterministic chaos is thought to be involved in many physical situations including the onset of turbulence in fluids, chemical reactions and plasma physics. Secondly, we demonstrate the use of the formalism in nonlinear system modelling by providing a graphic example in which it is clear that the neural network has accurately modelled the nonlinear transfer function. It is interesting to note that the formalism provides explicit, analytic, global, approximations to the nonlinear maps underlying the various time series. Furthermore, the neural net seems to be extremely parsimonious in its requirements for data points from the time series. We show that the neural net is able to perform well because it globally approximates the relevant maps by performing a kind of generalized mode decomposition of the maps. 24 refs., 13 figs.

  2. FireSignal-Data acquisition and control system software

    Energy Technology Data Exchange (ETDEWEB)

    Neto, A. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)], E-mail: andre.neto@cfn.ist.utl.pt; Fernandes, H.; Duarte, A.; Carvalho, B.B.; Sousa, J.; Valcarcel, D.F. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal); Hron, M. [Asociace EURATOM IPP.CR, Prague (Czech Republic); Varandas, C.A.F. [Associacao Euratom/IST, Centro de Fusao Nuclear, Av. Rovisco Pais, P-1049-001 Lisboa (Portugal)

    2007-10-15

    Control of fusion experiments requires non-ambiguous, easy to use, user-interfaces to configure hardware devices. With that aim, a highly generic system for data control and acquisition has been developed. Among the main features it allows remote hardware configuration, shot launching, data sharing between connected users and experiment monitoring. The system is fully distributed: the hardware driver nodes, clients and servers are completely independent from each other and might run in different operating systems and programmed in different languages. All the communication is provided through the Common Object Request Broker Architecture (CORBA) protocol. FireSignal is designed to be as independent as possible from any kind of constraints as it is a plugin based system. Database, data viewers and the security system are some examples of what can easily be changed and adapted to the target machine's needs. In this system, every hardware is described in eXtensible Markup Language (XML) and with this information Graphical User Interfaces (GUI) are automatically built and user's parameter configuration validated. Any type of hardware device can be integrated in the system as long as it is described in XML and the respective driver developed. Any modern programming language can be used to develop these drivers. Currently Python and Java generic drivers are used. Data storage and indexing is time stamp event-based. Nodes are responsible for tagging the acquired samples with the absolute time stamps and to react to machine events. FireSignal is currently being used to control the ISTTOK/PT and CASTOR/CZ tokamaks.

  3. FireSignal-Data acquisition and control system software

    International Nuclear Information System (INIS)

    Neto, A.; Fernandes, H.; Duarte, A.; Carvalho, B.B.; Sousa, J.; Valcarcel, D.F.; Hron, M.; Varandas, C.A.F.

    2007-01-01

    Control of fusion experiments requires non-ambiguous, easy to use, user-interfaces to configure hardware devices. With that aim, a highly generic system for data control and acquisition has been developed. Among the main features it allows remote hardware configuration, shot launching, data sharing between connected users and experiment monitoring. The system is fully distributed: the hardware driver nodes, clients and servers are completely independent from each other and might run in different operating systems and programmed in different languages. All the communication is provided through the Common Object Request Broker Architecture (CORBA) protocol. FireSignal is designed to be as independent as possible from any kind of constraints as it is a plugin based system. Database, data viewers and the security system are some examples of what can easily be changed and adapted to the target machine's needs. In this system, every hardware is described in eXtensible Markup Language (XML) and with this information Graphical User Interfaces (GUI) are automatically built and user's parameter configuration validated. Any type of hardware device can be integrated in the system as long as it is described in XML and the respective driver developed. Any modern programming language can be used to develop these drivers. Currently Python and Java generic drivers are used. Data storage and indexing is time stamp event-based. Nodes are responsible for tagging the acquired samples with the absolute time stamps and to react to machine events. FireSignal is currently being used to control the ISTTOK/PT and CASTOR/CZ tokamaks

  4. 2012 Proceedings of the International Conference on Communications, Signal Processing, and Systems

    CERN Document Server

    Wang, Wei; Mu, Jiasong; Liang, Jing; Zhang, Baoju; Pi, Yiming; Zhao, Chenglin

    2012-01-01

    Communications, Signal Processing, and Systems is a collection of contributions coming out of the International Conference on Communications, Signal Processing, and Systems (CSPS) held October 2012. This book provides the state-of-art developments of Communications, Signal Processing, and Systems, and their interactions in multidisciplinary fields, such as Smart Grid. The book also examines Radar Systems, Sensor Networks, Radar Signal Processing, Design and Implementation of Signal Processing Systems and Applications. Written by experts and students in the fields of Communications, Signal Processing, and Systems.

  5. Energy Signal Tool for Decision Support in Building Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Henze, G. P.; Pavlak, G. S.; Florita, A. R.; Dodier, R. H.; Hirsch, A. I.

    2014-12-01

    A prototype energy signal tool is demonstrated for operational whole-building and system-level energy use evaluation. The purpose of the tool is to give a summary of building energy use which allows a building operator to quickly distinguish normal and abnormal energy use. Toward that end, energy use status is displayed as a traffic light, which is a visual metaphor for energy use that is either substantially different from expected (red and yellow lights) or approximately the same as expected (green light). Which light to display for a given energy end use is determined by comparing expected to actual energy use. As expected, energy use is necessarily uncertain; we cannot choose the appropriate light with certainty. Instead, the energy signal tool chooses the light by minimizing the expected cost of displaying the wrong light. The expected energy use is represented by a probability distribution. Energy use is modeled by a low-order lumped parameter model. Uncertainty in energy use is quantified by a Monte Carlo exploration of the influence of model parameters on energy use. Distributions over model parameters are updated over time via Bayes' theorem. The simulation study was devised to assess whole-building energy signal accuracy in the presence of uncertainty and faults at the submetered level, which may lead to tradeoffs at the whole-building level that are not detectable without submetering.

  6. Effects of HVDC on power systems small signal angle stability

    Energy Technology Data Exchange (ETDEWEB)

    Custodio, D.T.; Paccini, R.O.; Kopcak, I.; Costa, V.F. da [State University of Campinas (UNICAMP), SP (Brazil). School of Electrical and Computer Engineering. Power Systems Dept.], Emails: totti@dsee.fee.unicamp.br, rodrigo@dsee.fee.unicamp.br, kopcak@dsee.fee.unicamp.br, vivaldo@dsee.fee.unicamp.br

    2009-07-01

    In this paper, a didactic method for parameters tuning of the Power Oscillation Damper (POD) coupled to the HVDC constant current controller is proposed utilizing the MATLAB package with a control system toolbox. First, modal analysis is done from the system state matrix to determine the critical mode and oscillation natural frequency. Input and output linearized matrixes are built to single-input and single-output (SISO) control systems. The phase to be compensated between the active power flow in the parallel AC inter-tie and the current reference signal of the HVDC constant current controller is obtained from the Nyquist theorem. Following, the POD time constants are obtained. Finally, the static gain of the POD is tuned based on the root locus method of the classical control theory. Simulations results prove that the DC power modulation is efficient to damp the AC power oscillations. This method is straightforward because only involves matrix operation. (author)

  7. Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems

    CERN Document Server

    Thiriet, Marc

    2013-01-01

    The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of...

  8. Fault Tolerant Neural Network for ECG Signal Classification Systems

    Directory of Open Access Journals (Sweden)

    MERAH, M.

    2011-08-01

    Full Text Available The aim of this paper is to apply a new robust hardware Artificial Neural Network (ANN for ECG classification systems. This ANN includes a penalization criterion which makes the performances in terms of robustness. Specifically, in this method, the ANN weights are normalized using the auto-prune method. Simulations performed on the MIT ? BIH ECG signals, have shown that significant robustness improvements are obtained regarding potential hardware artificial neuron failures. Moreover, we show that the proposed design achieves better generalization performances, compared to the standard back-propagation algorithm.

  9. Systems Biomedicine of Rabies Delineates the Affected Signaling pathways

    Directory of Open Access Journals (Sweden)

    Sayed Hamid Reza Mozhgani

    2016-11-01

    Full Text Available The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that causes lethal encephalomyelitis. Although there have been a plethora of studies investigating the etiological mechanism of the rabies virus and many precautionary methods have been implemented to avert the disease outbreak over the last century, the disease has surprisingly no definite remedy at its late stages. The psychological symptoms and the underlying etiology, as well as the rare survival rate from rabies encephalitis, has still remained a mystery. We, therefore, undertook a systems biomedicine approach to identify the network of gene products implicated in rabies. This was done by meta-analyzing whole-transcriptome microarray datasets of the CNS infected by strain CVS-11, and integrating them with interactome data using computational and statistical methods. We first determined the differentially expressed genes (DEGs in each study and horizontally integrated the results at the mRNA and microRNA levels separately. A total of 61 seed genes involved in signal propagation system were obtained by means of unifying mRNA and microRNA detected integrated DEGs. We then reconstructed a refined protein-protein interaction network (PPIN of infected cells to elucidate the rabies-implicated signal transduction network (RISN. To validate our findings, we confirmed differential expression of randomly selected genes in the network using Real-time PCR. In conclusion, the identification of seed genes and their network neighborhood within the refined PPIN can be useful for demonstrating signaling pathways including interferon circumvent, toward proliferation and survival, and neuropathological clue, explaining the intricate underlying molecular neuropathology of rabies infection and thus rendered a molecular framework for predicting potential drug targets.

  10. Systems Biomedicine of Rabies Delineates the Affected Signaling Pathways

    Science.gov (United States)

    Azimzadeh Jamalkandi, Sadegh; Mozhgani, Sayed-Hamidreza; Gholami Pourbadie, Hamid; Mirzaie, Mehdi; Noorbakhsh, Farshid; Vaziri, Behrouz; Gholami, Alireza; Ansari-Pour, Naser; Jafari, Mohieddin

    2016-01-01

    The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that causes lethal encephalomyelitis. Although there have been a plethora of studies investigating the etiological mechanism of the rabies virus and many precautionary methods have been implemented to avert the disease outbreak over the last century, the disease has surprisingly no definite remedy at its late stages. The psychological symptoms and the underlying etiology, as well as the rare survival rate from rabies encephalitis, has still remained a mystery. We, therefore, undertook a systems biomedicine approach to identify the network of gene products implicated in rabies. This was done by meta-analyzing whole-transcriptome microarray datasets of the CNS infected by strain CVS-11, and integrating them with interactome data using computational and statistical methods. We first determined the differentially expressed genes (DEGs) in each study and horizontally integrated the results at the mRNA and microRNA levels separately. A total of 61 seed genes involved in signal propagation system were obtained by means of unifying mRNA and microRNA detected integrated DEGs. We then reconstructed a refined protein–protein interaction network (PPIN) of infected cells to elucidate the rabies-implicated signal transduction network (RISN). To validate our findings, we confirmed differential expression of randomly selected genes in the network using Real-time PCR. In conclusion, the identification of seed genes and their network neighborhood within the refined PPIN can be useful for demonstrating signaling pathways including interferon circumvent, toward proliferation and survival, and neuropathological clue, explaining the intricate underlying molecular neuropathology of rabies infection and thus rendered a molecular framework for predicting potential drug targets. PMID:27872612

  11. Systems Biomedicine of Rabies Delineates the Affected Signaling Pathways.

    Science.gov (United States)

    Azimzadeh Jamalkandi, Sadegh; Mozhgani, Sayed-Hamidreza; Gholami Pourbadie, Hamid; Mirzaie, Mehdi; Noorbakhsh, Farshid; Vaziri, Behrouz; Gholami, Alireza; Ansari-Pour, Naser; Jafari, Mohieddin

    2016-01-01

    The prototypical neurotropic virus, rabies, is a member of the Rhabdoviridae family that causes lethal encephalomyelitis. Although there have been a plethora of studies investigating the etiological mechanism of the rabies virus and many precautionary methods have been implemented to avert the disease outbreak over the last century, the disease has surprisingly no definite remedy at its late stages. The psychological symptoms and the underlying etiology, as well as the rare survival rate from rabies encephalitis, has still remained a mystery. We, therefore, undertook a systems biomedicine approach to identify the network of gene products implicated in rabies. This was done by meta-analyzing whole-transcriptome microarray datasets of the CNS infected by strain CVS-11, and integrating them with interactome data using computational and statistical methods. We first determined the differentially expressed genes (DEGs) in each study and horizontally integrated the results at the mRNA and microRNA levels separately. A total of 61 seed genes involved in signal propagation system were obtained by means of unifying mRNA and microRNA detected integrated DEGs. We then reconstructed a refined protein-protein interaction network (PPIN) of infected cells to elucidate the rabies-implicated signal transduction network (RISN). To validate our findings, we confirmed differential expression of randomly selected genes in the network using Real-time PCR. In conclusion, the identification of seed genes and their network neighborhood within the refined PPIN can be useful for demonstrating signaling pathways including interferon circumvent, toward proliferation and survival, and neuropathological clue, explaining the intricate underlying molecular neuropathology of rabies infection and thus rendered a molecular framework for predicting potential drug targets.

  12. Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Takayuki Katsuyama

    2018-05-01

    Full Text Available Systemic lupus erythematosus (SLE is a chronic multi-organ debilitating autoimmune disease, which mainly afflicts women in the reproductive years. A complex interaction of genetics, environmental factors and hormones result in the breakdown of immune tolerance to “self” leading to damage and destruction of multiple organs, such as the skin, joints, kidneys, heart and brain. Both innate and adaptive immune systems are critically involved in the misguided immune response against self-antigens. Dendritic cells, neutrophils, and innate lymphoid cells are important in initiating antigen presentation and propagating inflammation at lymphoid and peripheral tissue sites. Autoantibodies produced by B lymphocytes and immune complex deposition in vital organs contribute to tissue damage. T lymphocytes are increasingly being recognized as key contributors to disease pathogenesis. CD4 T follicular helper cells enable autoantibody production, inflammatory Th17 subsets promote inflammation, while defects in regulatory T cells lead to unchecked immune responses. A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease. In this review, we focus on the aberrations in T cell signaling in SLE and highlight therapeutic advances in this field.

  13. Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

    Science.gov (United States)

    Katsuyama, Takayuki; Tsokos, George C.; Moulton, Vaishali R.

    2018-01-01

    Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune disease, which mainly afflicts women in the reproductive years. A complex interaction of genetics, environmental factors and hormones result in the breakdown of immune tolerance to “self” leading to damage and destruction of multiple organs, such as the skin, joints, kidneys, heart and brain. Both innate and adaptive immune systems are critically involved in the misguided immune response against self-antigens. Dendritic cells, neutrophils, and innate lymphoid cells are important in initiating antigen presentation and propagating inflammation at lymphoid and peripheral tissue sites. Autoantibodies produced by B lymphocytes and immune complex deposition in vital organs contribute to tissue damage. T lymphocytes are increasingly being recognized as key contributors to disease pathogenesis. CD4 T follicular helper cells enable autoantibody production, inflammatory Th17 subsets promote inflammation, while defects in regulatory T cells lead to unchecked immune responses. A better understanding of the molecular defects including signaling events and gene regulation underlying the dysfunctional T cells in SLE is necessary to pave the path for better management, therapy, and perhaps prevention of this complex disease. In this review, we focus on the aberrations in T cell signaling in SLE and highlight therapeutic advances in this field. PMID:29868033

  14. The Bucket System – A computer mediated signaling system for group improvisation

    DEFF Research Database (Denmark)

    Dahlstedt, Palle; Nilsson, Per Anders; Robair, Gino

    2015-01-01

    The Bucket System is a new system for computer-mediated ensemble improvisation, designed by improvisers for improvisers. Coming from a tradition of structured free ensemble improvisation practices (comprovisation), influenced by post-WW2 experimental music practices, it is a signaling system...

  15. Improper Gaussian Signaling in Interference-Limited Systems

    KAUST Repository

    Gaafar, Mohamed

    2016-05-01

    In the last decade, wireless applications have witnessed a tremendous growth. This can be envisioned in the surge of smart devices which became almost in everyone\\'s possession, demand for high speed connection and the internet of things (IoT) along with its enabling technologies. Hence, the multiuser interference became the main limiting factor in wireless communications. Moreover, just like diamonds and emeralds, the electromagnetic spectrum is limited and precious. Therefore, the high data rate application may not be satisfied by our current technologies. In order to solve this spectrum scarcity problem, researchers have steered their focus to develop new techniques such as cognitive radio (CR) and in-band full-duplex (FD). However, these systems suffer from the interference problem that can dramatically impede their quality-of-service (QoS). Therefore, investigating communication techniques/systems that can relieve the interference adverse signature becomes imperative. Improper Gaussian signaling (IGS) has been recently shown to outperform the traditional proper Gaussian signaling (PGS) in several interference-limited systems. In this thesis, we use IGS in order to mitigate the interference issue in three different communication settings. IGS has the ability to control the interference signal dimension, and hence, it can be considered as one form of interference alignment. In the first part, we investigate an underlay CR system with in-band FD primary users (PUs) and one-way communication for the secondary user (SU). IGS is employed to alleviate the interference introduced by the SU on the PUs. First, we derive a closed form expression and an upper bound for the SU and PUs outage probabilities, respectively. Second, we optimize the SU signal parameters, represented in its power and the circularity coefficient, to achieve the design objectives of the SU while satisfying certain QoS constraints for the PU under instantaneous, average and partial channel state

  16. Multi-Modal Intelligent Traffic Signal Systems (MMITSS) Basic Safety Message

    Data.gov (United States)

    Department of Transportation — Data were collected during the Multi-Modal Intelligent Transportation Signal Systems (MMITSS) study. MMITSS is a next-generation traffic signal system that seeks to...

  17. Multi-Modal Intelligent Traffic Signal Systems Vehicle Trajectories for Roadside Equipment

    Data.gov (United States)

    Department of Transportation — Data were collected during the Multi-Modal Intelligent Transportation Signal Systems (MMITSS) study. MMITSS is a next-generation traffic signal system that seeks to...

  18. New Train Run Monitoring system: Getting the most out of an ERTMS level 2 Signalling system

    DEFF Research Database (Denmark)

    Richter, Troels; Landex, Alex; Andersen, Jonas Lohmann Elkjær

    . Rail Net Denmark is currently implementing ERTMS Level 2 signalling systems on the entire long distance network and a CBTC signalling system on the Copenhagen Suburban network. It is unlikely, that the current RDS will be able to function in this environment and especially be capable of taking...... advantage of the additional data delivered by the new systems. The conceptual design of a new RDS has consequently been underway since the start of the signalling program. The vision is to create an automatic system that delivers “perfect train run histories” with a cause for every time loss. The future...... ERTMS Traffic Management System will include a rescheduler: Every time a train leaves its path, a rescheduling is triggered and the train receives a new timetable. As a part of this process, other trains may also be rescheduled. A concept for converting this information into the “perfect train run...

  19. The COP9 signalosome converts temporal hormone signaling to spatial restriction on neural competence.

    Directory of Open Access Journals (Sweden)

    Yi-Chun Huang

    2014-11-01

    Full Text Available During development, neural competence is conferred and maintained by integrating spatial and temporal regulations. The Drosophila sensory bristles that detect mechanical and chemical stimulations are arranged in stereotypical positions. The anterior wing margin (AWM is arrayed with neuron-innervated sensory bristles, while posterior wing margin (PWM bristles are non-innervated. We found that the COP9 signalosome (CSN suppresses the neural competence of non-innervated bristles at the PWM. In CSN mutants, PWM bristles are transformed into neuron-innervated, which is attributed to sustained expression of the neural-determining factor Senseless (Sens. The CSN suppresses Sens through repression of the ecdysone signaling target gene broad (br that encodes the BR-Z1 transcription factor to activate sens expression. Strikingly, CSN suppression of BR-Z1 is initiated at the prepupa-to-pupa transition, leading to Sens downregulation, and termination of the neural competence of PWM bristles. The role of ecdysone signaling to repress br after the prepupa-to-pupa transition is distinct from its conventional role in activation, and requires CSN deneddylating activity and multiple cullins, the major substrates of deneddylation. Several CSN subunits physically associate with ecdysone receptors to represses br at the transcriptional level. We propose a model in which nuclear hormone receptors cooperate with the deneddylation machinery to temporally shutdown downstream target gene expression, conferring a spatial restriction on neural competence at the PWM.

  20. Characteristic parameters of electromagnetic signals from a human heart system

    International Nuclear Information System (INIS)

    Liu Xin-Yuan; Wang Yin; Zhang Su-Ming; Gao Hong-Lei; Pei Liu-Qing; Dai Yuan-Dong

    2011-01-01

    The electromagnetic field of a human heart system is a bioelectromagnetic field. Electrocardiography (ECG) and magnetocardiography (MCG) are both carriers of electromagnetic information about the cardiac system, and they are nonstationary signals. In this study, ECG and MCG data from healthy subjects are acquired; the MCG data are captured using a high-T c radio frequency superconducting quantum interference device (HTc rf SQUIDs) and the QRS complexes in these data are analysed by the evolutionary spectrum analysis method. The results show that the quality factor Q and the central frequency f z of the QRS complex evolutionary spectrum are the characteristic parameters (CHPs) of ECG and MCG in the time—frequency domain. The confidence intervals of the mean values of the CHPs are estimated by the Student t distribution method in mathematical statistics. We believe that there are threshold ranges of the mean values of Q and f z for healthy subjects. We have postulated the following criterion: if the mean values of CHPs are in the proper ranges, the cardiac system is in a normal condition and it possesses the capability of homeostasis. In contrast, if the mean values of the CHPs do not lie in the proper ranges, the homeostasis of the cardiac system is lacking and some cardiac disease may follow. The results and procedure of MCG CHPs in the study afford a technological route for the application of HTc rf SQUIDs in cardiology. (condensed matter: electronic structure, electrical, magnetic, and optical properties)

  1. Androgenic signaling systems and their role in behavioral evolution.

    Science.gov (United States)

    Fuxjager, Matthew J; Schuppe, Eric R

    2018-06-05

    Sex steroids mediate the organization and activation of masculine reproductive phenotypes in diverse vertebrate taxa. However, the effects of sex steroid action in this context vary tremendously, in that steroid action influences reproductive physiology and behavior in markedly different ways (even among closely related species). This leads to the idea that the mechanisms underlying sex steroid action similarly differ across vertebrates in a manner that supports diversification of important sexual traits. Here, we highlight the Evolutionary Potential Hypothesis as a framework for understanding how androgen-dependent reproductive behavior evolves. This idea posits that the cellular mechanisms underlying androgenic action can independently evolve within a given target tissue to adjust the hormone's functional effects. The result is a seemingly endless number of permutations in androgenic signaling pathways that can be mapped onto the incredible diversity of reproductive phenotypes. One reason this hypothesis is important is because it shifts current thinking about the evolution of steroid-dependent traits away from an emphasis on circulating steroid levels and toward a focus on molecular mechanisms of hormone action. To this end, we also provide new empirical data suggesting that certain cellular modulators of androgen action-namely, the co-factors that dynamically adjust transcritpional effects of steroid action either up or down-are also substrates on which evolution can act. We then close the review with a detailed look at a case study in the golden-collared manakin (Manacus vitellinus). Work in this tropical bird shows how androgenic signaling systems are modified in specific parts of the skeletal muscle system to enhance motor performance necessary to produce acrobatic courtship displays. Altogether, this paper seeks to develop a platform to better understand how steroid action influences the evolution of complex animal behavior. Copyright © 2018 Elsevier Ltd

  2. Signal transduction in cells of the immune system in microgravity

    Directory of Open Access Journals (Sweden)

    Huber Kathrin

    2008-10-01

    Full Text Available Abstract Life on Earth developed in the presence and under the constant influence of gravity. Gravity has been present during the entire evolution, from the first organic molecule to mammals and humans. Modern research revealed clearly that gravity is important, probably indispensable for the function of living systems, from unicellular organisms to men. Thus, gravity research is no more or less a fundamental question about the conditions of life on Earth. Since the first space missions and supported thereafter by a multitude of space and ground-based experiments, it is well known that immune cell function is severely suppressed in microgravity, which renders the cells of the immune system an ideal model organism to investigate the influence of gravity on the cellular and molecular level. Here we review the current knowledge about the question, if and how cellular signal transduction depends on the existence of gravity, with special focus on cells of the immune system. Since immune cell function is fundamental to keep the organism under imnological surveillance during the defence against pathogens, to investigate the effects and possible molecular mechanisms of altered gravity is indispensable for long-term space flights to Earth Moon or Mars. Thus, understanding the impact of gravity on cellular functions on Earth will provide not only important informations about the development of life on Earth, but also for therapeutic and preventive strategies to cope successfully with medical problems during space exploration.

  3. Linear circuits, systems and signal processing: theory and application

    International Nuclear Information System (INIS)

    Byrnes, C.I.; Saeks, R.E.; Martin, C.F.

    1988-01-01

    In part because of its universal role as a first approximation of more complicated behaviour and in part because of the depth and breadth of its principle paradigms, the study of linear systems continues to play a central role in control theory and its applications. Enhancing more traditional applications to aerospace and electronics, application areas such as econometrics, finance, and speech and signal processing have contributed to a renaissance in areas such as realization theory and classical automatic feedback control. Thus, the last few years have witnessed a remarkable research effort expended in understanding both new algorithms and new paradigms for modeling and realization of linear processes and in the analysis and design of robust control strategies. The papers in this volume reflect these trends in both the theory and applications of linear systems and were selected from the invited and contributed papers presented at the 8th International Symposium on the Mathematical Theory of Networks and Systems held in Phoenix on June 15-19, 1987

  4. SIBYLLE: an expert system for the interpretation in real time of mono-dimensional signals; application to vocal signal

    International Nuclear Information System (INIS)

    Minault, Sophie

    1987-01-01

    This report presents an interactive tool for computer aided building of signals processing and interpretation systems. This tool includes three main parts: - an expert system, - a rule compiler, - a real time procedural system. The expert system allows the acquisition of knowledge about the signal. Knowledge has to be formalized as a set of rewriting rules (or syntaxical rules) and is introduced with an interactive interface. The compiler makes a compilation of the knowledge base (the set of rules) and generates a procedural system, which is equivalent to the expert system. The generated procedural system is a fixed one but is much faster than the expert system: it can work in real time. The expert system is used along the experimental phase on a small corpus of data: the knowledge base is then tested and possibly modified thanks to the interactive interface. Once the knowledge base is steady enough, the procedural system is generated and tested on a bigger data corpus. This allows to perform significant statistical studies which generally induce some corrections at the expert system level. The overall constitutes a tool which conciliates the expert systems flexibility with the procedural systems speed. It has been used for building a set of recognition rules modules on vocal signal - module of sound-silence detection - module of voiced-unvoiced segmentation - module of synchronous pitch detection. Its possibilities are not limited to the study of vocal signal, but can be enlarged to any mono-dimensional signal processing. A feasibility study has been realised for an electrocardiograms application. (author) [fr

  5. Engineering satellite-based navigation and timing global navigation satellite systems, signals, and receivers

    CERN Document Server

    Betz, J

    2016-01-01

    This book describes the design and performance analysis of satnav systems, signals, and receivers. It also provides succinct descriptions and comparisons of all the world’s satnav systems. Its comprehensive and logical structure addresses all satnav signals and systems in operation and being developed. Engineering Satellite-Based Navigation and Timing: Global Navigation Satellite Systems, Signals, and Receivers provides the technical foundation for designing and analyzing satnav signals, systems, and receivers. Its contents and structure address all satnav systems and signals: legacy, modernized, and new. It combines qualitative information with detailed techniques and analyses, providing a comprehensive set of insights and engineering tools for this complex multidisciplinary field. Part I describes system and signal engineering including orbital mechanics and constellation design, signal design principles and underlying considerations, link budgets, qua tifying receiver performance in interference, and e...

  6. Carbon price signal. Impact Analysis on the European Electricity System

    International Nuclear Information System (INIS)

    2016-03-01

    The Paris Agreement signed by 195 countries late in December 2015, after COP 21, created a new basis for efficient cooperation between countries in the fight against climate change. The technologies being rolled out by the electricity sector will have very different impacts on climate change and, for the time being, investments other than public aid for renewable energies are being guided primarily by prices. To shed more slight on the issue of greenhouse gas emissions, which is closely related to the challenges addressed at COP21, RTE initiated a study in 2015 based on the models used in its Generation Adequacy Report. ADEME wanted to contribute to this effort and offer its support. The present document outlines the approach taken to assessing the impact of the carbon price signal on emissions from the European electric power system, its production costs and its structural evolution over the medium term. This approach was discussed with members of the 'Network Outlook Committee' of the Transmission System Users' Committee which includes environmental NGOs as well as the main economic actors from the power sector. Key findings resulting from the analysis developed in this report include: Simulations conducted with the current generation fleet show that the carbon price would have to be close to euro 30/tonne at the European level to drive a significant reduction in emissions (about 100 million tonnes a year, or 15 %) from the European power sector. A higher price of about euro 100/tonne would help drive an emissions reduction of close to 30%. Over the medium and long terms, beyond an impact on the number of hours fossil fuel power plants would be run, having a high carbon price would send a signal encouraging investment in renewable energies and could incentivise the development of flexible and storage capacity. It would notably guarantee the profitability of gas-fired plants and renewable power development. The following assumptions are factored into the study

  7. The Denver region traffic signal system improvement program : planning for management and operations

    Science.gov (United States)

    2009-04-01

    The Denver Regional Council of Governments (DRCOG) works with over 30 local jurisdictions on the Traffic Signal System Improvement Program (TSSIP), a combination of management and operations strategies designed to time and coordinate traffic signals ...

  8. Gamma-butyrolactone and furan signaling systems in Streptomyces.

    Science.gov (United States)

    Sidda, John D; Corre, Christophe

    2012-01-01

    Streptomyces bacteria produce different classes of diffusible signaling molecules that trigger secondary metabolite production and/or morphological development within the cell population. The biosynthesis of gamma-butyrolactones (GBLs) and 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids (AHFCAs) signaling molecules is related and involves an essential AfsA-like butenolide synthase. This chapter first describes the catalytic role of AfsA-like enzyme then provides details about methods for the discovery and characterization of potentially novel signaling molecules. In section 4, one approach for establishing the biological role of these signaling molecules is presented. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. Prenatal Alcohol Exposure Damages Brain Signal Transduction Systems

    National Research Council Canada - National Science Library

    Caldwell, Kevin

    2001-01-01

    .... One and twenty-four hours following fear conditioning this learning deficit is associated with altered brain signal transduction mechanisms that are dependent on an enzyme termed phosphatidylinositol...

  10. Radiation-hardened fast acquisition/weak signal tracking system and method

    Science.gov (United States)

    Winternitz, Luke (Inventor); Boegner, Gregory J. (Inventor); Sirotzky, Steve (Inventor)

    2009-01-01

    A global positioning system (GPS) receiver and method of acquiring and tracking GPS signals comprises an antenna adapted to receive GPS signals; an analog radio frequency device operatively connected to the antenna and adapted to convert the GPS signals from an analog format to a digital format; a plurality of GPS signal tracking correlators operatively connected to the analog RF device; a GPS signal acquisition component operatively connected to the analog RF device and the plurality of GPS signal tracking correlators, wherein the GPS signal acquisition component is adapted to calculate a maximum vector on a databit correlation grid; and a microprocessor operatively connected to the plurality of GPS signal tracking correlators and the GPS signal acquisition component, wherein the microprocessor is adapted to compare the maximum vector with a predetermined correlation threshold to allow the GPS signal to be fully acquired and tracked.

  11. Design of General-purpose Industrial signal acquisition system in a large scientific device

    Science.gov (United States)

    Ren, Bin; Yang, Lei

    2018-02-01

    In order to measure the industrial signal of a large scientific device experiment, a set of industrial data general-purpose acquisition system has been designed. It can collect 4~20mA current signal and 0~10V voltage signal. Through the practical experiments, it shows that the system is flexible, reliable, convenient and economical, and the system has characters of high definition and strong anti-interference ability. Thus, the system fully meets the design requirements..

  12. Statistical Signal Processing in Humanitarian Mine Clerance Systems

    DEFF Research Database (Denmark)

    Karlsen, Brian; Sørensen, Helge Bjarup Dissing; Larsen, Jan

    2002-01-01

    Denne artikel beskriver kortfattet metoder og resultater relateret til clutterreduktion (clutter: uønskede reflekterede signaler) i jordradar- (eng. ground penetrating radar, GPR) signaler vha. statistiske signalbehandlingsmetoder baseret på Independent Component Analysis (ICA). Formålet ved denne...

  13. Radiation-induced PKC signaling system in cultured rat hepatocytes

    International Nuclear Information System (INIS)

    Nakajima, Tetsuo; Yukawa, Osami

    1998-01-01

    Radiation effects on living organisms are mainly caused through reactive oxygen species (ROS) on living cells. It is known that ROS damages various membranes and the bio membranes play an important role in cellular signal transduction pathways. The effects of radiation on cellular signal transduction pathways in cultured rat hepatocytes have been studied

  14. Encryption and validation of multiple signals for optical identification systems

    Energy Technology Data Exchange (ETDEWEB)

    Perez-Cabre, E [Universitat PoliteGcnica de Catalunya, Department Optica i Optometria, Violinista Vellsola 37, 08222 Terrassa (Spain); Millan, M S [Universitat PoliteGcnica de Catalunya, Department Optica i Optometria, Violinista Vellsola 37, 08222 Terrassa (Spain); Javidi, B [University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Road, CT 06269 Storrs (United States)

    2007-07-15

    Multifactor encryption-authentication technique reinforces optical security by allowing the simultaneous A N D-verification of more than one primary image. Instead of basing the identification on a unique signature or piece of information, our goal is to authenticate a given person, object, vehicle by the simultaneous recognition of several factors. Some of them are intrinsic to the person and object or vehicle under control. Other factors, act as keys of the authentication step. Such a system is proposed for situations such as the access control to restricted areas, where the demand of security is high. The multifactor identification method involves double random-phase encoding, fully phase-based encryption and a combined nonlinear joint transform correlator and a classical 4f-correlator for simultaneous recognition and authentication of multiple images. The encoded signal fulfils the general requirements of invisible content, extreme difficulty in counterfeiting and real-time automatic verification. Four reference double-phase encoded images are compared with the retrieved input images obtained in situ from the person or the vehicle whose authentication is wanted and from a database. A recognition step based on the correlation between the signatures and the stored references determines the authentication or rejection of the person and object under surveillance.

  15. Encryption and validation of multiple signals for optical identification systems

    International Nuclear Information System (INIS)

    Perez-Cabre, E; Millan, M S; Javidi, B

    2007-01-01

    Multifactor encryption-authentication technique reinforces optical security by allowing the simultaneous A N D-verification of more than one primary image. Instead of basing the identification on a unique signature or piece of information, our goal is to authenticate a given person, object, vehicle by the simultaneous recognition of several factors. Some of them are intrinsic to the person and object or vehicle under control. Other factors, act as keys of the authentication step. Such a system is proposed for situations such as the access control to restricted areas, where the demand of security is high. The multifactor identification method involves double random-phase encoding, fully phase-based encryption and a combined nonlinear joint transform correlator and a classical 4f-correlator for simultaneous recognition and authentication of multiple images. The encoded signal fulfils the general requirements of invisible content, extreme difficulty in counterfeiting and real-time automatic verification. Four reference double-phase encoded images are compared with the retrieved input images obtained in situ from the person or the vehicle whose authentication is wanted and from a database. A recognition step based on the correlation between the signatures and the stored references determines the authentication or rejection of the person and object under surveillance

  16. Perturbation Biology: Inferring Signaling Networks in Cellular Systems

    Science.gov (United States)

    Miller, Martin L.; Gauthier, Nicholas P.; Jing, Xiaohong; Kaushik, Poorvi; He, Qin; Mills, Gordon; Solit, David B.; Pratilas, Christine A.; Weigt, Martin; Braunstein, Alfredo; Pagnani, Andrea; Zecchina, Riccardo; Sander, Chris

    2013-01-01

    We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series of perturbations of cancer cell lines by targeted drugs, singly or in combination. The response to perturbation is quantified in terms of relative changes in the measured levels of proteins, phospho-proteins and cellular phenotypes such as viability. Computational network models are derived de novo, i.e., without prior knowledge of signaling pathways, and are based on simple non-linear differential equations. The prohibitively large solution space of all possible network models is explored efficiently using a probabilistic algorithm, Belief Propagation (BP), which is three orders of magnitude faster than standard Monte Carlo methods. Explicit executable models are derived for a set of perturbation experiments in SKMEL-133 melanoma cell lines, which are resistant to the therapeutically important inhibitor of RAF kinase. The resulting network models reproduce and extend known pathway biology. They empower potential discoveries of new molecular interactions and predict efficacious novel drug perturbations, such as the inhibition of PLK1, which is verified experimentally. This technology is suitable for application to larger systems in diverse areas of molecular biology. PMID:24367245

  17. METHODS FOR QUALITY ENHANCEMENT OF USER VOICE SIGNAL IN VOICE AUTHENTICATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    O. N. Faizulaieva

    2014-03-01

    Full Text Available The reasonability for the usage of computer systems user voice in the authentication process is proved. The scientific task for improving the signal/noise ratio of the user voice signal in the authentication system is considered. The object of study is the process of input and output of the voice signal of authentication system user in computer systems and networks. Methods and means for input and extraction of voice signal against external interference signals are researched. Methods for quality enhancement of user voice signal in voice authentication systems are suggested. As modern computer facilities, including mobile ones, have two-channel audio card, the usage of two microphones is proposed in the voice signal input system of authentication system. Meanwhile, the task of forming a lobe of microphone array in a desired area of voice signal registration (100 Hz to 8 kHz is solved. The usage of directional properties of the proposed microphone array gives the possibility to have the influence of external interference signals two or three times less in the frequency range from 4 to 8 kHz. The possibilities for implementation of space-time processing of the recorded signals using constant and adaptive weighting factors are investigated. The simulation results of the proposed system for input and extraction of signals during digital processing of narrowband signals are presented. The proposed solutions make it possible to improve the value of the signal/noise ratio of the useful signals recorded up to 10, ..., 20 dB under the influence of external interference signals in the frequency range from 4 to 8 kHz. The results may be useful to specialists working in the field of voice recognition and speaker’s discrimination.

  18. Ecdysone receptor (EcR) and ultraspiracle (USP) genes from the cyclopoid copepod Paracyclopina nana: Identification and expression in response to water accommodated fractions (WAFs).

    Science.gov (United States)

    Puthumana, Jayesh; Lee, Min-Chul; Han, Jeonghoon; Kim, Hui-Su; Hwang, Dae-Sik; Lee, Jae-Seong

    2017-02-01

    Ecdysteroid hormones are pivotal in the development, growth, and molting of arthropods, and the hormone pathway is triggered by binding ecdysteroid to a heterodimer of the two nuclear receptors; ecdysone receptors (EcR) and ultraspiracle (USP). We have characterized EcR and USP genes, and their 5'-untranslated region (5'-UTR) from the copepod Paracyclopina nana, and studied mRNA transcription levels in post-embryonic stages and in response to water accommodated fractions (WAFs) of crude oil. The open reading frames (ORF) of EcR and USP were 1470 and 1287bp that encoded 490 and 429 amino acids with molecular weight of 121.18 and 105.03kDa, respectively. Also, a well conserved DNA-binding domain (DBD) and ligand-binding domain (LBD) were identified which confirmed by phylogenetic analysis. Messenger RNA transcriptional levels of EcR and USP were developmental stage-specific in early post-embryonic stages (N3-4). However, an evoked expression of USP was observed throughout copepodid stage and in adult females. WAFs (40 and 80%) were acted as an ecdysone agonist in P. nana, and elicited the mRNA transcription levels in adults. Developmental stage-specific transcriptional activation of EcR and USP in response to WAFs was observed. USP gene was down-regulated in the nauplius in response to WAF, whereas up-regulation of USP was observed in the adults. This study represents the first data of molecular elucidation of EcR and USP genes and their regulatory elements from P. nana and the developmental stage specific expression in response to WAFs, which can be used as potential biomarkers for environmental stressors with ecotoxicological evaluations in copepods. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Multi-Purpose Radio Signal Generation System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The MRSiG will be able to replace many of the expensive, highly specialized RF signal generators with cheaper generic boxes that can be customized as the...

  20. Light Emitting Diode (LED) circular traffic signal lifetime management system.

    Science.gov (United States)

    2011-02-01

    The objective of this research is to build lifetime curves for red, yellow, and green LED circular traffic signals through 20,000-hr. accelerated stress testing of samples operating under Louisianas environmental conditions.

  1. Outage performance of cognitive radio systems with Improper Gaussian signaling

    KAUST Repository

    Amin, Osama; Abediseid, Walid; Alouini, Mohamed-Slim

    2015-01-01

    design the SU signal by adjusting its transmitted power and the circularity coefficient to minimize the SU outage probability while maintaining a certain PU quality-of-service. Finally, we evaluate the proposed bounds and adaptive algorithms by numerical

  2. Intelligent classification of electrocardiogram (ECG) signal using extended Kalman Filter (EKF) based neuro fuzzy system.

    Science.gov (United States)

    Meau, Yeong Pong; Ibrahim, Fatimah; Narainasamy, Selvanathan A L; Omar, Razali

    2006-05-01

    This study presents the development of a hybrid system consisting of an ensemble of Extended Kalman Filter (EKF) based Multi Layer Perceptron Network (MLPN) and a one-pass learning Fuzzy Inference System using Look-up Table Scheme for the recognition of electrocardiogram (ECG) signals. This system can distinguish various types of abnormal ECG signals such as Ventricular Premature Cycle (VPC), T wave inversion (TINV), ST segment depression (STDP), and Supraventricular Tachycardia (SVT) from normal sinus rhythm (NSR) ECG signal.

  3. A low noise photoelectric signal acquisition system applying in nuclear magnetic resonance gyroscope

    Science.gov (United States)

    Lu, Qilin; Zhang, Xian; Zhao, Xinghua; Yang, Dan; Zhou, Binquan; Hu, Zhaohui

    2017-10-01

    The nuclear magnetic resonance gyroscope serves as a new generation of strong support for the development of high-tech weapons, it solves the core problem that limits the development of the long-playing seamless navigation and positioning. In the NMR gyroscope, the output signal with atomic precession frequency is detected by the probe light, the final crucial photoelectric signal of the probe light directly decides the quality of the gyro signal. But the output signal has high sensitivity, resolution and measurement accuracy for the photoelectric detection system. In order to detect the measured signal better, this paper proposed a weak photoelectric signal rapid acquisition system, which has high SNR and the frequency of responded signal is up to 100 KHz to let the weak output signal with high frequency of the NMR gyroscope can be detected better.

  4. Real time pressure signal system for a rotary engine

    Science.gov (United States)

    Rice, W. J. (Inventor)

    1984-01-01

    A real-time IMEP signal which is a composite of those produced in any one chamber of a three-lobed rotary engine is developed by processing the signals of four transducers positioned in a Wankel engine housing such that the rotor overlaps two of the transducers for a brief period during each cycle. During the overlap period of any two transducers, their output is compared and sampled for 10 microseconds per 0.18 degree of rotation by a sampling switch and capacitive circuit. When the switch is closed, the instantaneous difference between the value of the transducer signals is provided while with the switch open the average difference is produced. This combined signal, along with the original signal of the second transducer, is fed through a multiplexer to a pressure output terminal. Timing circuits, controlled by a crank angle encoder on the engine, determine which compared transducer signals are applied to the output terminal and when, as well as the open and closed periods of the switches.

  5. Motor-related signals in the auditory system for listening and learning.

    Science.gov (United States)

    Schneider, David M; Mooney, Richard

    2015-08-01

    In the auditory system, corollary discharge signals are theorized to facilitate normal hearing and the learning of acoustic behaviors, including speech and music. Despite clear evidence of corollary discharge signals in the auditory cortex and their presumed importance for hearing and auditory-guided motor learning, the circuitry and function of corollary discharge signals in the auditory cortex are not well described. In this review, we focus on recent developments in the mouse and songbird that provide insights into the circuitry that transmits corollary discharge signals to the auditory system and the function of these signals in the context of hearing and vocal learning. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. A portable system for acquiring and removing motion artefact from ECG signals

    Science.gov (United States)

    Griffiths, A.; Das, A.; Fernandes, B.; Gaydecki, P.

    2007-07-01

    A novel electrocardiograph (ECG) signal acquisition and display system is under development. It is designed for patients ranging from the elderly to athletes. The signals are obtained from electrodes integrated into a vest, amplified, digitally processed and transmitted via Bluetooth to a PC with a Labview ® interface. Digital signal processing is performed to remove movement artefact and electromyographic (EMG) noise, which severely distorts signal morphology and complicates clinical diagnosis. Independent component analysis (ICA) is also used to improve the signal quality. The complete system will integrate the electronics into a single module which will be embedded in the vest.

  7. A portable system for acquiring and removing motion artefact from ECG signals

    Energy Technology Data Exchange (ETDEWEB)

    Griffiths, A; Das, A; Fernandes, B; Gaydecki, P [School of Electrical and Electronic Engineering, University of Manchester, PO Box 88, Manchester M60 1QD (United Kingdom)

    2007-07-15

    A novel electrocardiograph (ECG) signal acquisition and display system is under development. It is designed for patients ranging from the elderly to athletes. The signals are obtained from electrodes integrated into a vest, amplified, digitally processed and transmitted via Bluetooth to a PC with a Labview (registered) interface. Digital signal processing is performed to remove movement artefact and electromyographic (EMG) noise, which severely distorts signal morphology and complicates clinical diagnosis. Independent component analysis (ICA) is also used to improve the signal quality. The complete system will integrate the electronics into a single module which will be embedded in the ves000.

  8. Phosphate sink containing two-component signaling systems as tunable threshold devices

    DEFF Research Database (Denmark)

    Amin, Munia; Kothamachu, Varun B; Feliu, Elisenda

    2014-01-01

    Synthetic biology aims to design de novo biological systems and reengineer existing ones. These efforts have mostly focused on transcriptional circuits, with reengineering of signaling circuits hampered by limited understanding of their systems dynamics and experimental challenges. Bacterial two......-component signaling systems offer a rich diversity of sensory systems that are built around a core phosphotransfer reaction between histidine kinases and their output response regulator proteins, and thus are a good target for reengineering through synthetic biology. Here, we explore the signal-response relationship...... rapid signal termination, whereby one of the RRs acts as a phosphate sink towards the other RR (i.e. the output RR), but also implements a sigmoidal signal-response relationship. We identify two mathematical conditions on system parameters that are necessary for sigmoidal signal-response relationships...

  9. Radiotracers For Lipid Signaling Pathways In Biological Systems

    Energy Technology Data Exchange (ETDEWEB)

    Gatley, S. J. [Northeastern Univ., Boston, MA (United States)

    2016-09-26

    The primary focus of this project continues to be the development of radiotracers and radiotracer methodology for studying physiology and biochemistry. The compounds that have been labeled areacylethanolamines and acylglycerols that are, as classes, represented in both in plants and in animals. In the latter, some of these act as ligands for cannabinoid receptors and they are therefore known as endocannabinoids. Cannabinoid receptors are not found in plant genomes so that plants must contain other receptors and signaling systems that use acylethanolamines. Relatively little work has been done on that issue, though acylethanolamines do modulate plant growth and stress resistance, thus possessing obvious relevance to agriculture and energy production. Progress has been described in five peer-reviewed papers and seven meeting abstracts. Preparation of 2-acylglycerol lipid messengers in high purity. A novel enzymatic synthesis was developedthat gave pure 2-acylglycerols free of any rearrrangement to the thermodynamically more stable 1(3)-acylglycerol byproducts. The method utilized 1,3-dibutyryl-2-acylglycerol substrate ethanolysis by a resinimobilized lipase. Thus, pure radiolabeled 2-acylglycerols can now be conveniently prepared just prior to their utilization. These synthetic studies were published in the Journal of Medicinal Chemistry, 2011. Diacylglycerol lipase assay methodology. Diacylglycerol lipases (DAGLs) generate 2- acylglycerols, and are thus potential targets for disease- or growth-modifying agents, by means of reducing formation of 2-acylglycerols. A radioTLC assay of the hydrolysis of radiolabeled diglyceride substrate [1''-carbon-14]2-arachidonoyl-1-stearoyl-sn-glycerol has been implemented, and used to validate a novel, potentially highthroughput fluorescence resonance energy transfer (FRET) based assay. A number of new DAGL inhibitors that have selectivity for DAGLs were synthesized and screened. This work was very recently published in

  10. Low level signal data acquisition for the MFTF-B superconducting magnet system

    International Nuclear Information System (INIS)

    Montoya, C.R.

    1984-01-01

    Acquisition of low level signals from sensors mounted on the superconducting magnets in the Tandem Mirror Fusion Test Facility (MFTF-B) impose very strict requirements on the magnet signal conditioning and data acquisition system. Of the various types of sensors required, thermocouples and strain gages produce very low level outputs. These low level outputs must be accurately measured in the harsh environment of slowly varying magnetic fields, cryogenic temperatures, high vacuum, 80 kV pulse power, 60 Hz, 17 MHz and 28, 35, and 56 GHz electrical noise and possible neutron radiation. Successful measurements require careful attention to grounding, shielding, signal handling and processing in the data acquisition system. The magnet instrumentation system provides a means of effectively measuring both low level signals and high level signals from all types of sensors. Various methods involved in the design and implementation of the system for signal conditioning and data gathering will be presented

  11. An offset tone based gain stabilization technique for mixed-signal RF measurement systems

    Energy Technology Data Exchange (ETDEWEB)

    Joshi, Gopal, E-mail: gjos@barc.gov.in [BARC, Mumbai 400085 (India); Motiwala, Paresh D.; Randale, G.D.; Singh, Pitamber [BARC, Mumbai 400085 (India); Agarwal, Vivek; Kumar, Girish [IIT Bombay, Powai, Mumbai 400076 (India)

    2015-09-21

    This paper describes a gain stabilization technique for a RF signal measurement system. A sinusoidal signal of known amplitude, phase and close enough in frequency is added to the main, to be measured RF signal at the input of the analog section. The system stabilizes this offset tone in the digital domain, as it is sampled at the output of the analog section. This process generates a correction factor needed to stabilize the magnitude of the gain of the analog section for the main RF signal. With the help of a simple calibration procedure, the absolute amplitude of the main RF signal can be measured. The technique is especially suited for a system that processes signals around a single frequency, employs direct signal conversion into the digital domain, and processes subsequent steps in an FPGA. The inherent parallel signal processing in an FPGA-based implementation allows a real time stabilization of the gain. The effectiveness of the technique is derived from the fact, that the gain stabilization stamped to the main RF signal measurement branch requires only a few components in the system to be inherently stable. A test setup, along with experimental results is presented from the field of RF instrumentation for particle accelerators. Due to the availability of a phase synchronized RF reference signal in these systems, the measured phase difference between the main RF and the RF reference is also stabilized using this technique. A scheme of the signal processing is presented, where a moving average filter has been used to filter out not only the unwanted frequencies, but also to separate the main RF signal from the offset tone signal. This is achieved by a suitable choice of sampling and offset tone frequencies. The presented signal processing scheme is suitable to a variety of RF measurement applications.

  12. A low-cost biomedical signal transceiver based on a Bluetooth wireless system.

    Science.gov (United States)

    Fazel-Rezai, Reza; Pauls, Mark; Slawinski, David

    2007-01-01

    Most current wireless biomedical signal transceivers use range-limiting communication. This work presents a low-cost biomedical signal transceiver that uses Bluetooth wireless technology. The design is implemented in a modular form to be adaptable to different types of biomedical signals. The signal front end obtains and processes incoming signals, which are then transmitted via a microcontroller and wireless module. Near real-time receive software in LabVIEW was developed to demonstrate the system capability. The completed transmitter prototype successfully transmits ECG signals, and is able to simultaneously send multiple signals. The sampling rate of the transmitter is fast enough to send up to thirteen ECG signals simultaneously, with an error rate below 0.1% for transmission exceeding 65 meters. A low-cost wireless biomedical transceiver has many applications, such as real-time monitoring of patients with a known condition in non-clinical settings.

  13. The response of a linear monostable system and its application in parameters estimation for PSK signals

    Science.gov (United States)

    Duan, Chaowei; Zhan, Yafeng

    2016-03-01

    The output characteristics of a linear monostable system driven with a periodic signal and an additive white Gaussian noise are studied in this paper. Theoretical analysis shows that the output signal-to-noise ratio (SNR) decreases monotonously with the increasing noise intensity but the output SNR-gain is stable. Inspired by this high SNR-gain phenomenon, this paper applies the linear monostable system in the parameters estimation algorithm for phase shift keying (PSK) signals and improves the estimation performance.

  14. Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis

    DEFF Research Database (Denmark)

    Zhang, Hongbin; Schulz, Tim J; Espinoza, Daniel O

    2010-01-01

    Both insulin and bone morphogenetic protein (BMP) signaling systems are important for adipocyte differentiation. Analysis of gene expression in BMP7-treated fibroblasts revealed a coordinated change in insulin signaling components by BMP7. To further investigate the cross talk between insulin...... BMP7's suppressive effect on pref-1 transcription. Together, these data suggest cross talk between the insulin and BMP signaling systems by which BMP7 can rescue brown adipogenesis in cells with insulin resistance....

  15. Design and implementation of a hybrid circuit system for micro sensor signal processing

    International Nuclear Information System (INIS)

    Wang Zhuping; Chen Jing; Liu Ruqing

    2011-01-01

    This paper covers a micro sensor analog signal processing circuit system (MASPS) chip with low power and a digital signal processing circuit board implementation including hardware connection and software design. Attention has been paid to incorporate the MASPS chip into the digital circuit board. The ultimate aim is to form a hybrid circuit used for mixed-signal processing, which can be applied to a micro sensor flow monitoring system. (semiconductor integrated circuits)

  16. Nuclear spectrometry signal acquisition and processing system based on LabVIEW and C

    International Nuclear Information System (INIS)

    Chen Xiaojun; Fang Fang; Chen Mingchi; Jiang Zancheng; Wang Min

    2008-01-01

    The process of designing nuclear spectrometry signal acquisition and processing system based on virtual instrument technology is showed in this article. For the deficiency of LabVIEW in big data analyzing and processing, a method is presented in which C programmer is inserted and applied in signal smoothing, peak searching and area of the peak calculating. A complete nuclear spectrometry signal acquisition, processing and document management system is implemented. (authors)

  17. Fast optical signal processing in high bit rate OTDM systems

    DEFF Research Database (Denmark)

    Poulsen, Henrik Nørskov; Jepsen, Kim Stokholm; Clausen, Anders

    1998-01-01

    As all-optical signal processing is maturing, optical time division multiplexing (OTDM) has also gained interest for simple networking in high capacity backbone networks. As an example of a network scenario we show an OTDM bus interconnecting another OTDM bus, a single high capacity user...

  18. Measurement of signal-to-noise ratio performance of TV fluoroscopy systems

    International Nuclear Information System (INIS)

    Geluk, R.J.

    1985-01-01

    A method has been developed for direct measurement of Signal-to-Noise ratio performance on X-ray TV systems. To this end the TV signal resulting from a calibrated test object, is compared with the noise level in the image. The method is objective and produces instantaneous readout, which makes it very suitable for system evaluation under dynamic conditions. (author)

  19. The POU Factor Ventral Veins Lacking/Drifter Directs the Timing of Metamorphosis through Ecdysteroid and Juvenile Hormone Signaling

    Science.gov (United States)

    Chaieb, Leila; Koyama, Takashi; Sarwar, Prioty; Mirth, Christen K.; Smith, Wendy A.; Suzuki, Yuichiro

    2014-01-01

    Although endocrine changes are known to modulate the timing of major developmental transitions, the genetic mechanisms underlying these changes remain poorly understood. In insects, two developmental hormones, juvenile hormone (JH) and ecdysteroids, are coordinated with each other to induce developmental changes associated with metamorphosis. However, the regulation underlying the coordination of JH and ecdysteroid synthesis remains elusive. Here, we examined the function of a homolog of the vertebrate POU domain protein, Ventral veins lacking (Vvl)/Drifter, in regulating both of these hormonal pathways in the red flour beetle, Tribolium castaneum (Tenebrionidae). RNA interference-mediated silencing of vvl expression led to both precocious metamorphosis and inhibition of molting in the larva. Ectopic application of a JH analog on vvl knockdown larvae delayed the onset of metamorphosis and led to a prolonged larval stage, indicating that Vvl acts upstream of JH signaling. Accordingly, vvl knockdown also reduced the expression of a JH biosynthesis gene, JH acid methyltransferase 3 (jhamt3). In addition, ecdysone titer and the expression of the ecdysone response gene, hormone receptor 3 (HR3), were reduced in vvl knockdown larvae. The expression of the ecdysone biosynthesis gene phantom (phm) and spook (spo) were reduced in vvl knockdown larvae in the anterior and posterior halves, respectively, indicating that Vvl might influence ecdysone biosynthesis in both the prothoracic gland and additional endocrine sources. Injection of 20-hydroxyecdysone (20E) into vvl knockdown larvae could restore the expression of HR3 although molting was never restored. These findings suggest that Vvl coordinates both JH and ecdysteroid biosynthesis as well as molting behavior to influence molting and the timing of metamorphosis. Thus, in both vertebrates and insects, POU factors modulate the production of major neuroendocrine regulators during sexual maturation. PMID:24945490

  20. The response of a linear monostable system and its application in parameters estimation for PSK signals

    International Nuclear Information System (INIS)

    Duan, Chaowei; Zhan, Yafeng

    2016-01-01

    The output characteristics of a linear monostable system driven with a periodic signal and an additive white Gaussian noise are studied in this paper. Theoretical analysis shows that the output signal-to-noise ratio (SNR) decreases monotonously with the increasing noise intensity but the output SNR-gain is stable. Inspired by this high SNR-gain phenomenon, this paper applies the linear monostable system in the parameters estimation algorithm for phase shift keying (PSK) signals and improves the estimation performance. - Highlights: • The response of a linear monostable system driven with a periodic signal and an additive white Gaussian noise is analyzed. • The optimal parameter of this linear monostable system to maximum the output SNR-gain is obtained. • Application of this linear monostable system in parameters estimation algorithm for PSK signals obtains performance improvement.

  1. PPARs Signaling and Cancer in the Gastrointestinal System

    Directory of Open Access Journals (Sweden)

    Valerio Pazienza

    2012-01-01

    Full Text Available Nowadays, the study of the peroxisome proliferators activated receptors (PPARs as potential targets for cancer prevention and therapy has gained a strong interest. From a biological point of view, the overall responsibility of PPARs in cancer development and progression is still controversial since several studies report both antiproliferative and tumor-promoting actions for these signaling molecules in human cancer cells and animal models. In this paper, we discuss PPARs functions in the context of different types of gastrointestinal cancer.

  2. Signalling components of the house mouse mate recognition system

    Czech Academy of Sciences Publication Activity Database

    Bímová, Barbora; Albrecht, Tomáš; Macholán, Miloš; Piálek, Jaroslav

    2009-01-01

    Roč. 80, č. 1 (2009), s. 20-27 ISSN 0376-6357 R&D Projects: GA AV ČR IAA600930506 Institutional research plan: CEZ:AV0Z60930519; CEZ:AV0Z50450515 Keywords : Faeces * Olfactory communication * Salivary and rogen binding protein * Sexual preferences * Urinary signals Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 1.527, year: 2009

  3. Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis

    Directory of Open Access Journals (Sweden)

    Sung-Young Shin

    2016-08-01

    Full Text Available The Hippo signalling pathway has recently emerged as an important regulator of cell apoptosis and proliferation with significant implications in human diseases. In mammals, the pathway contains the core kinases MST1/2, which phosphorylate and activate LATS1/2 kinases. The pro-apoptotic function of the MST/LATS signalling axis was previously linked to the Akt and ERK MAPK pathways, demonstrating that the Hippo pathway does not act alone but crosstalks with other signalling pathways to coordinate network dynamics and cellular outcomes. These crosstalks were characterised by a multitude of complex regulatory mechanisms involving competitive protein-protein interactions and phosphorylation mediated feedback loops. However, how these different mechanisms interplay in different cellular contexts to drive the context-specific network dynamics of Hippo-ERK signalling remains elusive. Using mathematical modelling and computational analysis, we uncovered that the Hippo-ERK network can generate highly diverse dynamical profiles that can be clustered into distinct dose-response patterns. For each pattern, we offered mechanistic explanation that defines when and how the observed phenomenon can arise. We demonstrated that Akt displays opposing, dose-dependent functions towards ERK, which are mediated by the balance between the Raf-1/MST2 protein interaction module and the LATS1 mediated feedback regulation. Moreover, Ras displays a multi-functional role and drives biphasic responses of both MST2 and ERK activities; which are critically governed by the competitive protein interaction between MST2 and Raf-1. Our study represents the first in-depth and systematic analysis of the Hippo-ERK network dynamics and provides a concrete foundation for future studies.

  4. The role of lossless systems in modern digital signal processing: a tutorial

    OpenAIRE

    Vaidyanathan, P. P.; Doğanata, Zinnur

    1989-01-01

    A self-contained discussion of discrete-time lossless systems and their properties and relevance in digital signal processing is presented. The basic concept of losslessness is introduced, and several algebraic properties of lossless systems are studied. An understanding of these properties is crucial in order to exploit the rich usefulness of lossless systems in digital signal processing. Since lossless systems typically have many input and output terminals, a brief review of multiinput mult...

  5. Comparative effects of butyl benzyl phthalate (BBP) and di(2-ethylhexyl) phthalate (DEHP) on the aquatic larvae of Chironomus riparius based on gene expression assays related to the endocrine system, the stress response and ribosomes.

    Science.gov (United States)

    Planelló, Rosario; Herrero, Oscar; Martínez-Guitarte, José Luis; Morcillo, Gloria

    2011-09-01

    In this work, the effects of butyl benzyl phthalate (BBP) and di(2-ethylhexyl) phthalate (DEHP), two of the most extensively used phthalates, were studied in Chironomus riparius under acute short-term treatments, to compare their relative toxicities and identify genes sensitive to exposure. The ecotoxicity of these phthalates was assessed by analysis of the alterations in gene expression profiles of selected inducible and constitutive genes related to the endocrine system, the cellular stress response and the ribosomal machinery. Fourth instar larvae, a model system in aquatic toxicology, were experimentally exposed to five increasing concentrations (0.01, 0.1, 1, 10, and 100mg/L) of DEHP and BBP for 24h. Gene expression was analysed by the changes in levels of transcripts, using RT-PCR techniques with specific gene probes. The exposures to DEHP or BBP were able to rapidly induce the hsp70 gene in a concentration-dependent manner, whereas the cognate form hsc70 was not altered by either of these chemicals. Transcription of ribosomal RNA as a measure of cell viability, quantified by the levels of ITS2, was not affected by DEHP, but was slightly, yet significantly, downregulated by BBP at the highest concentrations tested. Finally, as these phthalates are classified as endocrine disruptor chemicals (EDCs), their potential effect on the ecdysone endocrine system was studied by analysing the two genes, EcR and usp, of the heterodimeric ecdysone receptor complex. It was found that BBP provoked the overexpression of the EcR gene, with significant increases from exposures of 0.1mg/L and above, while DEHP significantly decreased the activity of this gene at the highest concentration. These data are relevant as they show for the first time the ability of phthalates to interfere with endocrine marker genes in invertebrates, demonstrating their potential capacity to alter the ecdysone signalling pathway. Overall, the study clearly shows a differential gene-toxin interaction

  6. Troubleshooting of signal power supply system for Shanghai metro line 7

    Science.gov (United States)

    Lu, Kaixia; Xiao, Jie

    2018-03-01

    With the rapid development of Urban Rail Transit Signal Technology, the demand of signal power supply system for signal equipment is higher and higher. The signal intelligent power supply panel is the main component of the urban rail traffic signal power supply system. Whether the intelligent power supply panel working or not is directly related to traffic safety. The maintenance of intelligent signal power supply panel is particularly important. Line 7 of Shanghai Metro adopts PMZG Signal Intelligent Power Supply Panel, which is produced by Beijing Jinyujiaxin Polytron Technologies Inc. Maintenance of power supply system mainly includes routine maintenance and troubleshooting. This article will make clear the routine maintenance contents of PMZG Signal Intelligent Power Supply Panel, and put forward the common fault information and troubleshooting methods of PMZG Signal Intelligent Power Supply Panel. In accordance with the steps of fault handling, the faults can be eliminated in the shortest possible time, and PMZG Signal Intelligent Power Supply Panel can be quickly restored to normal working state.

  7. A SystemC-Based Design Methodology for Digital Signal Processing Systems

    Directory of Open Access Journals (Sweden)

    Christian Haubelt

    2007-03-01

    Full Text Available Digital signal processing algorithms are of big importance in many embedded systems. Due to complexity reasons and due to the restrictions imposed on the implementations, new design methodologies are needed. In this paper, we present a SystemC-based solution supporting automatic design space exploration, automatic performance evaluation, as well as automatic system generation for mixed hardware/software solutions mapped onto FPGA-based platforms. Our proposed hardware/software codesign approach is based on a SystemC-based library called SysteMoC that permits the expression of different models of computation well known in the domain of digital signal processing. It combines the advantages of executability and analyzability of many important models of computation that can be expressed in SysteMoC. We will use the example of an MPEG-4 decoder throughout this paper to introduce our novel methodology. Results from a five-dimensional design space exploration and from automatically mapping parts of the MPEG-4 decoder onto a Xilinx FPGA platform will demonstrate the effectiveness of our approach.

  8. Characterization of three digital signal processor systems used in gamma ray spectrometry

    International Nuclear Information System (INIS)

    Reguigui, N.; Morel, J.; Ben Kraiem, H.; Mahjoub, A.

    2002-01-01

    Various manufacturers have recently introduced digital signal processing systems that allow data acquisition in gamma spectrometry at high-input counting rates (several thousand pulses per second). In these systems, the signal digitization is performed immediately following the preamplification stage. This allows digital shaping and filtering of the signal which increases the number of possible combinations in signal shaping and as a consequence, optimizes the resolution as a function of the detector characteristics and the counting rate. Basic characteristic parameters of three digital signal processors that were recently introduced in the market have been studied and compared to those of an analog system. This study is carried out using a hyper-pure coaxial type germanium detector and 57 Co, 60 Co and 137 Cs radioactive sources. Performance parameters such as energy resolution, system throughput, and counting losses that are due to dead time and pile-up effects are presented and discussed

  9. Development of an integrated signal validation system and application to operating power plants

    International Nuclear Information System (INIS)

    Upadhyaya, B.R.; Holbert, K.E.; Kerlin, T.W.

    1989-01-01

    The objective of the university-industry joint research program at the University of Tennessee and Combustion Engineering, Inc. is to develop and implement a comprehensive signal validation system for current power plants and future advanced reactors. The integrated system consists of several parallel signal processing modules. The multi-modular decision information is combined to detect, isolate and characterize faulty signals. The signal validation system has been implemented in a VAX workstation and applied to operational data from a pressurized water reactor (PWR) and the Experimental Breeder Reactor-II (EBR-II). The use of the various signal validation techniques may be extended to predictive maintenance advising, instrument calibration verification, and to the development of intelligent instrumentation systems. 18 refs., 6 figs

  10. Design of signal reception and processing system of embedded ultrasonic endoscope

    Science.gov (United States)

    Li, Ming; Yu, Feng; Zhang, Ruiqiang; Li, Yan; Chen, Xiaodong; Yu, Daoyin

    2009-11-01

    Embedded Ultrasonic Endoscope, based on embedded microprocessor and embedded real-time operating system, sends a micro ultrasonic probe into coelom through the biopsy channel of the Electronic Endoscope to get the fault histology features of digestive organs by rotary scanning, and acquires the pictures of the alimentary canal mucosal surface. At the same time, ultrasonic signals are processed by signal reception and processing system, forming images of the full histology of the digestive organs. Signal Reception and Processing System is an important component of Embedded Ultrasonic Endoscope. However, the traditional design, using multi-level amplifiers and special digital processing circuits to implement signal reception and processing, is no longer satisfying the standards of high-performance, miniaturization and low power requirements that embedded system requires, and as a result of the high noise that multi-level amplifier brought, the extraction of small signal becomes hard. Therefore, this paper presents a method of signal reception and processing based on double variable gain amplifier and FPGA, increasing the flexibility and dynamic range of the Signal Reception and Processing System, improving system noise level, and reducing power consumption. Finally, we set up the embedded experiment system, using a transducer with the center frequency of 8MHz to scan membrane samples, and display the image of ultrasonic echo reflected by each layer of membrane, with a frame rate of 5Hz, verifying the correctness of the system.

  11. Method for signal conditioning and data acquisition system, based on variable amplification and feedback technique

    Energy Technology Data Exchange (ETDEWEB)

    Conti, Livio, E-mail: livio.conti@uninettunouniversity.net [Facoltà di Ingegneria, Università Telematica Internazionale Uninettuno, Corso Vittorio Emanuele II 39, 00186 Rome, Italy INFN Sezione Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy); Sgrigna, Vittorio [Dipartimento di Matematica e Fisica, Università Roma Tre, 84 Via della Vasca Navale, I-00146 Rome (Italy); Zilpimiani, David [National Institute of Geophysics, Georgian Academy of Sciences, 1 M. Alexidze St., 009 Tbilisi, Georgia (United States); Assante, Dario [Facoltà di Ingegneria, Università Telematica Internazionale Uninettuno, Corso Vittorio Emanuele II 39, 00186 Rome, Italy INFN Sezione Roma Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome (Italy)

    2014-08-21

    An original method of signal conditioning and adaptive amplification is proposed for data acquisition systems of analog signals, conceived to obtain a high resolution spectrum of any input signal. The procedure is based on a feedback scheme of the signal amplification with aim at maximizing the dynamic range and resolution of the data acquisition system. The paper describes the signal conditioning, digitization, and data processing procedures applied to an a priori unknown signal in order to enucleate its amplitude and frequency content for applications in different environments: on the ground, in space, or in the laboratory. An electronic board of the conditioning module has also been constructed and described. In the paper are also discussed the main fields of application and advantages of the method with respect to those known today.

  12. Method for signal conditioning and data acquisition system, based on variable amplification and feedback technique

    International Nuclear Information System (INIS)

    Conti, Livio; Sgrigna, Vittorio; Zilpimiani, David; Assante, Dario

    2014-01-01

    An original method of signal conditioning and adaptive amplification is proposed for data acquisition systems of analog signals, conceived to obtain a high resolution spectrum of any input signal. The procedure is based on a feedback scheme of the signal amplification with aim at maximizing the dynamic range and resolution of the data acquisition system. The paper describes the signal conditioning, digitization, and data processing procedures applied to an a priori unknown signal in order to enucleate its amplitude and frequency content for applications in different environments: on the ground, in space, or in the laboratory. An electronic board of the conditioning module has also been constructed and described. In the paper are also discussed the main fields of application and advantages of the method with respect to those known today

  13. Development of the signalling circuits for reactor emergency protection systems

    International Nuclear Information System (INIS)

    Volkov, A.V.; Nikiforov, B.N.; Ogon'kov, A.I.; Sychinskij, Yu.L.

    1978-01-01

    Construction of circuits for nuclear reactor emergency protection according to the power level and rate of power rise with the use of integrated microcircuits is discussed. Circuits of relay- and transformer-based logical signaling devices are presented. It is noted that disadvantages of a transformer-based loaical sianaling device are great power consumption (about 300 mW) and slow response limited by the time constant of the output smoothing filter. Further development of circuits under consideration is associated with the employment of new optronic elements intended to replace the transformers

  14. [Surface electromyography signal classification using gray system theory].

    Science.gov (United States)

    Xie, Hongbo; Ma, Congbin; Wang, Zhizhong; Huang, Hai

    2004-12-01

    A new method based on gray correlation was introduced to improve the identification rate in artificial limb. The electromyography (EMG) signal was first transformed into time-frequency domain by wavelet transform. Singular value decomposition (SVD) was then used to extract feature vector from the wavelet coefficient for pattern recognition. The decision was made according to the maximum gray correlation coefficient. Compared with neural network recognition, this robust method has an almost equivalent recognition rate but much lower computation costs and less training samples.

  15. Enhancement of the automatic ultrasonic signal processing system using digital technology

    International Nuclear Information System (INIS)

    Koo, In Soo; Park, H. Y.; Suh, Y. S.; Kim, D. Hoon; Huh, S.; Sung, S. H.; Jang, G. S.; Ryoo, S. G.; Choi, J. H.; Kim, Y. H.; Lee, J. C.; Kim, D. Hyun; Park, H. J.; Kim, Y. C.; Lee, J. P.; Park, C. H.; Kim, M. S.

    1999-12-01

    The objective of this study is to develop the automatic ultrasonic signal processing system which can be used in the inspection equipment to assess the integrity of the reactor vessel by enhancing the performance of the ultrasonic signal processing system. Main activities of this study divided into three categories such as the development of the circuits for generating ultrasonic signal and receiving the signal from the inspection equipment, the development of signal processing algorithm and H/W of the data processing system, and the development of the specification for application programs and system S/W for the analysis and evaluation computer. The results of main activities are as follows 1) the design of the ultrasonic detector and the automatic ultrasonic signal processing system by using the investigation of the state-of-the-art technology in the inside and outside of the country. 2) the development of H/W and S/W of the data processing system based on the results. Especially, the H/W of the data processing system, which have both advantages of digital and analog controls through the real-time digital signal processing, was developed using the DSP which can process the digital signal in the real-time, and was developed not only firmware of the data processing system in order for the peripherals but also the test algorithm of specimen for the calibration. The application programs and the system S/W of the analysis/evaluation computer were developed. Developed equipment was verified by the performance test. Based on developed prototype for the automatic ultrasonic signal processing system, the localization of the overall ultrasonic inspection equipment for nuclear industries would be expected through the further studies of the H/W establishment of real applications, developing the S/W specification of the analysis computer. (author)

  16. High-speed ultra-wideband wireless signals over fiber systems: photonic generation and DSP detection

    DEFF Research Database (Denmark)

    Yu, Xianbin; Gibbon, Timothy Braidwood; Tafur Monroy, Idelfonso

    2009-01-01

    We firstly review the efforts in the literature on ultra-wideband (UWB)-over-fiber systems. Secondly, we present experimental results on photonic generation of high-speed UWB signals by both direct modulation and external optical injecting an uncooled semiconductor laser. Furthermore, we introduce...... the use of digital signal processing (DSP) technology to receive the generated UWB signal at 781.25 Mbit/s. Error-free transmission is achieved....

  17. Signal shape registration in the JINR synchrophasotron slowly extracted beam parameter control system

    International Nuclear Information System (INIS)

    Volkov, V.I.; Kulikov, I.I.; Romanov, S.V.

    1982-01-01

    Signal shape registration in the JINR synchrophasotron slowly estracted beam parameter control system on-line with the ES-1010 computer is described. 32 input signals can be connected to the registrator. The maximum measurement rate of signal shape registration is about 38 kHz. The registrator consists of 32-channel analog multiplexer, 10-bit analog-to-digital converter, 1024-word buffer memory and control circuits. For information representation the colour TV monitor is used

  18. Development and testing of an integrated signal validation system for nuclear power plants

    International Nuclear Information System (INIS)

    Upadhayaya, B.R.; Kerlin, T.W.; Holbert, K.E.; Glockler, O.; Morgenstern, V.M.; Frei, Z.; Olvera, J.; Gaudio, P.J. Jr.

    1989-09-01

    The approach for signal validation, instrument fault isolation and characterization incorporates some of the methods used in the past, and new techniques developed under this project. The general architecture consists of parallel signal processing modules. Each of the modules performs a specific task. The current architecture consists of seven signal processing modules. There is no direct communication between the modules. Any cross information desired must be requested at the system executive level. 26 refs., 102 figs., 39 tabs

  19. PAM-4 signal delivery in one radio-over-fiber system

    Science.gov (United States)

    Wang, Hada; Zhou, Wen; Yu, Jianjun

    2017-10-01

    We propose and experimentally demonstrate four-level pulse-amplitude-modulation (PAM-4) signal delivery in a radio-over-fiber system for the first time. Over 8-Gbit/s PAM-4 signals have been transmitted over 20-km single-mode fiber-28 and 1-m wireless distance. The signal after transmission is detected directly by an envelope detector at the receiver side. The maximal bit rate could be increased if the bandpass amplifier and envelope detector have more bandwidth.

  20. Classification of EEG Signals by Radial Neuro-Fuzzy Systems

    Czech Academy of Sciences Publication Activity Database

    Coufal, David

    2006-01-01

    Roč. 5, č. 2 (2006), s. 415-423 ISSN 1109-2777 R&D Projects: GA MŠk ME 701 Institutional research plan: CEZ:AV0Z10300504 Keywords : neuro-fuzzy systems * radial fuzzy systems * data mining * hybrid systems Subject RIV: BA - General Mathematics

  1. Synthesis study of Texas signal control systems : technical report.

    Science.gov (United States)

    2012-09-01

    In recent years, several versions of traffic control systems have been established across the United States and within the state of Texas. There is a growing need to identify the various versions of these systems that exist, including the system hard...

  2. Brushless DC motor control system responsive to control signals generated by a computer or the like

    Science.gov (United States)

    Packard, Douglas T. (Inventor); Schmitt, Donald E. (Inventor)

    1987-01-01

    A control system for a brushless DC motor responsive to digital control signals is disclosed. The motor includes a multiphase wound stator and a permanent magnet rotor. The rotor is arranged so that each phase winding, when energized from a DC source, will drive the rotor through a predetermined angular position or step. A commutation signal generator responsive to the shaft position provides a commutation signal for each winding. A programmable control signal generator such as a computer or microprocessor produces individual digital control signals for each phase winding. The control signals and commutation signals associated with each winding are applied to an AND gate for that phase winding. Each gate controls a switch connected in series with the associated phase winding and the DC source so that each phase winding is energized only when the commutation signal and the control signal associated with that phase winding are present. The motor shaft may be advanced one step at a time to a desired position by applying a predetermined number of control signals in the proper sequence to the AND gates and the torque generated by the motor may be regulated by applying a separate control signal to each AND gate which is pulse width modulated to control the total time that each switch connects its associated winding to the DC source during each commutation period.

  3. Alcohol Control: Mobile Sensor System and Numerical Signal Analysis

    Directory of Open Access Journals (Sweden)

    Rolf SEIFERT

    2016-10-01

    Full Text Available An innovative mobile sensor system for alcohol control in the respiratory air is introduced. The gas sensor included in the sensor system is thermo-cyclically operated. Ethanol is the leading component in this context. However, other components occur in the breathing air which can influence the concentration determination of ethanol. Therefore, mono- ethanol samples and binary gas mixtures are measured by the sensor system and analyzed with a new calibration and evaluation procedure which is also incorporated in the system. The applications demonstrate a good substance identification capability of the sensor system and a very good concentration determination of the components.

  4. Noise and signal interference in optical fiber transmission systems an optimum design approach

    CERN Document Server

    Bottacchi, Stefano

    2008-01-01

    A comprehensive reference to noise and signal interference in optical fiber communications Noise and Signal Interference in Optical Fiber Transmission Systems is a compendium on specific topics within optical fiber transmission and the optimization process of the system design. It offers comprehensive treatment of noise and intersymbol interference (ISI) components affecting optical fiber communications systems, containing coverage on noise from the light source, the fiber and the receiver. The ISI is modeled with a statistical approach, leading to new useful computational m

  5. Low-level-signal data acquisition for the MFTF superconducting-magnet system

    International Nuclear Information System (INIS)

    Montoya, C.R.

    1981-01-01

    Acquisition of low level signals from sensors mounted on the superconducting yin-yang magnet in the Mirror Fusion Test Facility (MFTF) imposes very strict requirements on the magnet signal conditioning and data acquisition system. Of the various types of sensors required, thermocouples, strain gages, and voltage taps produce very low level outputs. These low level outputs must be accurately measured in the harsh environment of slowly varying magnetic fields, cryogenic temperatures, high vacuum, pulse power and 60 Hz electrical noise, possible neutron radiation, and high common mode voltage resulting from superconducting magnet quench. Successful measurements require careful attention to grounding, shielding, signal handling and processing in the data acquisition system. The magnet instrumentation system provides a means of effectively measuring both low level signals and high level signals from all types of sensors

  6. Design and measurement of signal processing system for cavity beam position monitor

    International Nuclear Information System (INIS)

    Wang Baopeng; Leng Yongbin; Yu Luyang; Zhou Weimin; Yuan Renxian; Chen Zhichu

    2013-01-01

    In this paper, in order to achieve the output signal processing of cavity beam position monitor (CBPM), we develop a digital intermediate frequency receiver architecture based signal processing system, which consists of radio frequency (RF) front end and high speed data acquisition board. The beam position resolution in the CBPM signal processing system is superior to 1 μm. Two signal processing algorithms, fast Fourier transform (FFT) and digital down converter (DDC), are evaluated offline using MATLAB platform, and both can be used to achieve, the CW input signal, position resolutions of 0.31 μm and 0.10 μm at -16 dBm. The DDC algorithm for its good compatibility is downloaded into the FPGA to realize online measurement, reaching the position resolution of 0.49 μm due to truncation error. The whole system works well and the performance meets design target. (authors)

  7. Development of NPP control room operators's mental workload measurement system using bioelectric signals

    International Nuclear Information System (INIS)

    Shim, Bong Sik; Oh, In Seok; Lee, Hyun Cheol; Cha, Kyung Ho; Lee, Dong Ha

    1996-09-01

    This study developed mentalload measurement system based on the relations between mentalload and physiological responses of the human operators. The measurement system was composed of the telemetry system for EEG, EOG, ECG and respiration pattern of the subjects, A/D converter, the physiological signal processing programs (compiled by the Labview). The signal processing programs transformed the physiological signal into the scores indicating mentalload status of the subjects and recorded the mentalload scores in the form of the table of a database. The acqknowledge and the labview programs additionally transformed the mentalload score database and the operator behavior database so that both database were consolidated into one. 94 figs., 57 refs. (Author)

  8. Dataset Documentation for the ERTMS-Oriented Signalling Maintenance in the Danish Railway System

    DEFF Research Database (Denmark)

    M. Pour, Shahrzad

    2017-01-01

    This documentation provides information about the dataset generated as part of a PhD thesis (Towards Signalling Maintenance Scheduling Problem for European Railway Traffic Management System ) for the signaling maintenance of the Danish railway system . The data instances (M.Pour 2018a; M.Pour 2018b......) have been created for the purpose of adaptation to the newest railway signalling standard which is so called European Railway Traffic Management System(ERTMS). The chapter provides explanation of the different types of maintenance tasks in the ERTMS, followed by data definition. Furthermore...

  9. The Preventive Signaling Maintenance Crew Scheduling Problem for European Railway Traffic Management system (ERTMS)

    DEFF Research Database (Denmark)

    M. Pour, Shahrzad; Stidsen, Thomas Jacob Riis; Rasmussen, Kourosh Marjani

    , the western part of Denmark. This case is particularly interesting, since the entire railway signalling system is currently being upgraded to the new European Railway Traffic Management System (ERTMS) standard. The new signals need continuous maintenance and in this article we plan the distribution of crew......A railway system is a large and complex infrastructure, which requires continuous maintenance in order to function correctly. Proper maintenance is critical but can also be costly. In this paper we consider the practical case of planning the preventive maintenance of railway signals in Jutland...

  10. Development of NPP control room operators`s mental workload measurement system using bioelectric signals

    Energy Technology Data Exchange (ETDEWEB)

    Shim, Bong Sik; Oh, In Seok; Lee, Hyun Cheol; Cha, Kyung Ho [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); Lee, Dong Ha [Suwon Univ., Suwon (Korea, Republic of)

    1996-09-01

    This study developed mentalload measurement system based on the relations between mentalload and physiological responses of the human operators. The measurement system was composed of the telemetry system for EEG, EOG, ECG and respiration pattern of the subjects, A/D converter, the physiological signal processing programs (compiled by the Labview). The signal processing programs transformed the physiological signal into the scores indicating mentalload status of the subjects and recorded the mentalload scores in the form of the table of a database. The acqknowledge and the labview programs additionally transformed the mentalload score database and the operator behavior database so that both database were consolidated into one. 94 figs., 57 refs. (Author).

  11. 2nd International Symposium on Signal Processing and Intelligent Recognition Systems

    CERN Document Server

    Bandyopadhyay, Sanghamitra; Krishnan, Sri; Li, Kuan-Ching; Mosin, Sergey; Ma, Maode

    2016-01-01

    This Edited Volume contains a selection of refereed and revised papers originally presented at the second International Symposium on Signal Processing and Intelligent Recognition Systems (SIRS-2015), December 16-19, 2015, Trivandrum, India. The program committee received 175 submissions. Each paper was peer reviewed by at least three or more independent referees of the program committee and the 59 papers were finally selected. The papers offer stimulating insights into biometrics, digital watermarking, recognition systems, image and video processing, signal and speech processing, pattern recognition, machine learning and knowledge-based systems. The book is directed to the researchers and scientists engaged in various field of signal processing and related areas. .

  12. Panel discussion : signals for capital investment : systems for assessing performance

    International Nuclear Information System (INIS)

    Shalaby, A.; Van Beers, R.; Keizer, C.; Taylor, R.; Rothstein, S.

    2003-01-01

    This session presented highlights of 5 panelists who discussed signals for capital investment in Ontario's newly opened electricity market. Four main issues were highlighted. The panelists emphasized that the industry does not want a market where the price is managed by anyone. They don't want government interference, which will undermine the market's integrity. In addition, the industry wants a market that reflects scarcity, as well as a transparent market, where all the necessary information is available to all players. It was noted that at the moment, green power is not the priority. Rather, emphasis should be placed on reliability, transmission planning, inter-regional coordination, and joint investments with neighbouring jurisdictions. figs

  13. Simulation of Weak Signals of Nanotechnology Innovation in Complex System

    Directory of Open Access Journals (Sweden)

    Sun Hi Yoo

    2018-02-01

    Full Text Available It is especially indispensable for new businesses or industries to predict the innovation of new technologies. This requires an understanding of how the complex process of innovation, which is accomplished through more efficient products, processes, services, technologies, or ideas, is adopted and diffused in the market, government, and society. Furthermore, detecting “weak signals” (signs of change in science and technology (S&T is also important to foretell events associated with innovations in technology. Thus, we explore the dynamic behavior of weak signals of a specific technological innovation using the agent-based simulating tool NetLogo. This study provides a deeper understanding of the early stages of complex technology innovation, and the models are capable of analyzing initial complex interaction structures between components of technologies and between agents engaged in collective invention.

  14. Development Of Signal Detection For Radar Navigation System

    Directory of Open Access Journals (Sweden)

    Theingi Win Hlaing

    2017-09-01

    Full Text Available This paper aims to evaluate the performance of target detection in the presence of sea clutter. Radar detection of a background of unwanted clutter due to echoes from sea clutter or land is a problem of interest in the radar field. Radar detector has been developed by assuming the radar clutter is Gaussian distributed. However as technology emerges the radar distribution is seen to deviates from the Gaussian assumption. Thus detectors designs based on Gaussian assumption are no longer optimum for detection in non-Gaussian nature. The theory of target detection in Gaussian distributed clutter has been well established and the closed form of the detection performances can be easily obtained. However that is not the case in non-Gaussian clutter distributions. The operation of radar detection is determined by radar detection theory with different types of Swerling target models such as Swerling I II III IV and V. By using MATLAB these signal detection techniques are developed.

  15. Electrical signal transfer system for a rotary kiln

    International Nuclear Information System (INIS)

    Tyson, J.H.; Kennett, L.P.; Davidson, I.S.

    1985-01-01

    A rotary kiln has a number of thermocouples respectively sensing the kiln temperature at spaced locations and respectively connected to annular slip rings. Laterally facing peripheral surfaces of the rings are respectively cooperable with brush contacts connected to a bar and a fork which embraces a ring moveable axially with the rings. Thus on longitudinal expansion of the kiln the contacts are caused to move with the rings. The electric signals from the thermocouples are thus fed to stationary monitoring equipment. In a modification the ring sections are electrically isolated and each section is connected to a respective sensor. Position sensors may be used to detect the rotary position of the kiln. The invention can be applied to other sensors. (author)

  16. Alcohol control: Mobile sensor system and numerical signal analysis

    OpenAIRE

    Seifert, Rolf; Keller, Hubert B.; Conrad, Thorsten; Peter, Jens

    2016-01-01

    An innovative mobile sensor system for alcohol control in the respiratory air is introduced. The gas sensor included in the sensor system is thermo-cyclically operated. Ethanol is the leading component in this context. However, other components occur in the breathing air which can influence the concentration determination of ethanol. Therefore, mono- ethanol samples and binary gas mixtures are measured by the sensor system and analyzed with a new calibration and evaluation procedure which is ...

  17. An ultra low energy biomedical signal processing system operating at near-threshold

    NARCIS (Netherlands)

    Hulzink, J.; Konijnenburg, M.; Ashouei, M.; Breeschoten, A.; Berset, T.; Huisken, J.; Stuyt, J.; Groot, H. de; Barat, F.; David, J.; Ginderdeuren, J. van

    2011-01-01

    This paper presents a voltage-scalable digital signal processing system designed for the use in a wireless sensor node (WSN) for ambulatory monitoring of biomedical signals. To fulfill the requirements of ambulatory monitoring, power consumption, which directly translates to the WSN battery lifetime

  18. Si(Li) x-ray spectrometer with signal processing system based on digital filtering

    International Nuclear Information System (INIS)

    Lakatos, Tamas

    1985-01-01

    A new signal processing system is under development at ATOMKI, Debrecen, Hungary, based on digital filtering by a microprocessor. The advantages of the new method are summarized. Dead time can be decreased and the speed of signal processing can be increased. Computer simulations verified the theoretical conclusions. (D.Gy.)

  19. A simple 5-DoF MR-compatible motion signal measurement system.

    Science.gov (United States)

    Chung, Soon-Cheol; Kim, Hyung-Sik; Yang, Jae-Woong; Lee, Su-Jeong; Choi, Mi-Hyun; Kim, Ji-Hye; Yeon, Hong-Won; Park, Jang-Yeon; Yi, Jeong-Han; Tack, Gye-Rae

    2011-09-01

    The purpose of this study was to develop a simple motion measurement system with magnetic resonance (MR) compatibility and safety. The motion measurement system proposed here can measure 5-DoF motion signals without deteriorating the MR images, and it has no effect on the intense and homogeneous main magnetic field, the temporal-gradient magnetic field (which varies rapidly with time), the transceiver radio frequency (RF) coil, and the RF pulse during MR data acquisition. A three-axis accelerometer and a two-axis gyroscope were used to measure 5-DoF motion signals, and Velcro was used to attach a sensor module to a finger or wrist. To minimize the interference between the MR imaging system and the motion measurement system, nonmagnetic materials were used for all electric circuit components in an MR shield room. To remove the effect of RF pulse, an amplifier, modulation circuit, and power supply were located in a shielded case, which was made of copper and aluminum. The motion signal was modulated to an optic signal using pulse width modulation, and the modulated optic signal was transmitted outside the MR shield room using a high-intensity light-emitting diode and an optic cable. The motion signal was recorded on a PC by demodulating the transmitted optic signal into an electric signal. Various kinematic variables, such as angle, acceleration, velocity, and jerk, can be measured or calculated by using the motion measurement system developed here. This system also enables motion tracking by extracting the position information from the motion signals. It was verified that MR images and motion signals could reliably be measured simultaneously.

  20. The Signal Detection and Control Circuit Design for Confocal Auto-Focus System

    OpenAIRE

    Yin Liu; Jin Yu; Zeqiang Mo

    2016-01-01

    Based on the demands of Confocal Auto-Focus system, the implementation method of signal measurement circuit and control circuit is given. Using the high performance instrumental amplifier AD620BN, low noise precision FET Op amplifier AD795JRZ and ultralow offset voltage Op amplifier OP07EP, a signal measurement circuit used to converse the two differential light intensity signal to electric signal is designed. And a control circuit which takes MCU MSP430F149 as core processes the former signa...

  1. Modelling Field Bus Communications in Mixed-Signal Embedded Systems

    Directory of Open Access Journals (Sweden)

    Alassir Mohamad

    2008-01-01

    Full Text Available Abstract We present a modelling platform using the SystemC-AMS language to simulate field bus communications for embedded systems. Our platform includes the model of an I/O controller IP (in this specific case an C controller that interfaces a master microprocessor with its peripherals on the field bus. Our platform shows the execution of the embedded software and its analog response on the lines of the bus. Moreover, it also takes into account the influence of the circuits's I/O by including their IBIS models in the SystemC-AMS description, as well as the bus lines imperfections. Finally, we present simulation results to validate our platform and measure the overhead introduced by SystemC-AMS over a pure digital SystemC simulation.

  2. Modelling Field Bus Communications in Mixed-Signal Embedded Systems

    Directory of Open Access Journals (Sweden)

    Patrick Garda

    2008-08-01

    Full Text Available We present a modelling platform using the SystemC-AMS language to simulate field bus communications for embedded systems. Our platform includes the model of an I/O controller IP (in this specific case an I2C controller that interfaces a master microprocessor with its peripherals on the field bus. Our platform shows the execution of the embedded software and its analog response on the lines of the bus. Moreover, it also takes into account the influence of the circuits's I/O by including their IBIS models in the SystemC-AMS description, as well as the bus lines imperfections. Finally, we present simulation results to validate our platform and measure the overhead introduced by SystemC-AMS over a pure digital SystemC simulation.

  3. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

    Directory of Open Access Journals (Sweden)

    Shenglong Zou

    2018-03-01

    Full Text Available The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R and 2. The CB1R is the prominent subtype in the central nervous system (CNS and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.

  4. Stochastic resonance in multi-stable coupled systems driven by two driving signals

    Science.gov (United States)

    Xu, Pengfei; Jin, Yanfei

    2018-02-01

    The stochastic resonance (SR) in multi-stable coupled systems subjected to Gaussian white noises and two different driving signals is investigated in this paper. Using the adiabatic approximation and the perturbation method, the coupled systems with four-well potential are transformed into the master equations and the amplitude of the response is obtained. The signal-to-noise ratio (SNR) is calculated numerically to demonstrate the occurrence of SR. For the case of two driving signals with different amplitudes, the interwell resonance between two wells S1 and S3 emerges for strong coupling. The SR can appear in the subsystem with weaker signal amplitude or even without driving signal with the help of coupling. For the case of two driving signals with different frequencies, the effects of SR in two subsystems driven by high and low frequency signals are both weakened with an increase in coupling strength. The stochastic multi-resonance phenomenon is observed in the subsystem subjected to the low frequency signal. Moreover, an effective scheme for phase suppressing SR is proposed by using a relative phase between two driving signals.

  5. The characterization of NMR signal for blood pressure monitoring system and its testing

    Directory of Open Access Journals (Sweden)

    Bambang Murdaka Eka Jati

    2016-02-01

    Full Text Available ABSTRACT A blood monitoring system based on NMR method has been designed on constructed. This set-up of equipment used magnetic permanent, radio frequency (RF, receiver coil (RC, function generator (FG, amplifier which included the filter, as well as the oscilloscope digital storage. The background of this research was based on the sensitivity of NMR signal. The signal must be separated from signals background. This method was done by adjusting the frequency on FG, which was connected to radio frequency (RF coil, on empty sample. Subsequently, NMR signal was received by RC, and that signal could be shown on oscilloscope at resonance condition. The true frequency on NMR signal was Larmor frequency, and the other was background. The two variables of this experiment were the position of RF coil and the location temperature (20 up to 30oC. In conclusion, the resonance frequency of NMR signal (as Larmor frequency was 4.7 MHz (at static magnetic field of 1,600 gauss and it could be separated from background signals (3.4 and 6.2 MHz, and that signal was almost constant to room temperature. The equipment was used for sample testing. It gave systole/diastole data of 110/70 mmHg (on sphygmomanometer that was similar to 17/9 mV (on NMR signal. ABSTRAK Telah dikembangkan alat pemantauan tekanan darah berdasar prinsip NMR.

  6. A Novel Medical E-Nose Signal Analysis System

    Directory of Open Access Journals (Sweden)

    Lu Kou

    2017-04-01

    Full Text Available It has been proven that certain biomarkers in people’s breath have a relationship with diseases and blood glucose levels (BGLs. As a result, it is possible to detect diseases and predict BGLs by analysis of breath samples captured by e-noses. In this paper, a novel optimized medical e-nose system specified for disease diagnosis and BGL prediction is proposed. A large-scale breath dataset has been collected using the proposed system. Experiments have been organized on the collected dataset and the experimental results have shown that the proposed system can well solve the problems of existing systems. The methods have effectively improved the classification accuracy.

  7. A ECG Signal Gathering and Displaying System Based on AVR

    Science.gov (United States)

    Ning, Li; Ruilan, Zhang; Jian, Liu; Xiaochen, Wang; Shuying, Chen; Zhuolin, Lang

    2017-12-01

    This article introduces a kind of system which is based on the AVR to acquire the data of ECG. Such system using the A/D function of ATmega8 chip and the lattice graph LCD to design ECG heart acquisition satisfies the demands above. This design gives a composition of hardware and programming of software about the system in detail which has mainly realized the real-time gathering, the amplifier, the filter, the A/D transformation and the LCD display. Since the AVR includes A/D transformation function and support embedded C language programming, it reduces the peripheral circuit, further more it also decreases the time to design and debug this system.

  8. Alternative vehicle detection technologies for traffic signal systems : technical report.

    Science.gov (United States)

    2009-02-01

    Due to the well-documented problems associated with inductive loops, most jurisdictions have : replaced many intersection loops with video image vehicle detection systems (VIVDS). While VIVDS : have overcome some of the problems with loops such as tr...

  9. Signal processing for LED lighting systems : illumination rendering and sensing

    NARCIS (Netherlands)

    Yang, H.

    2010-01-01

    Solid state lighting, employing high brightness light emitting diodes (LEDs), is becoming increasingly widely used. The advantages of LEDs include high radiative efficiency, long lifetime, limited heat generation and superior tolerance to humidity. Another important advantage of LED lighting systems

  10. Volatile-Mediated within-Plant Signaling in Hybrid Aspen: Required for Systemic Responses.

    Science.gov (United States)

    Li, Tao; Blande, James D

    2017-04-01

    Plant volatiles play crucial roles in signaling between plants and their associated community members, but their role in within-plant signaling remains largely unexplored, particularly under field conditions. Using a system comprising the hybrid aspen (Populus tremula x tremuloides) and the specialized herbivorous leaf beetle (Phratora laticollis) and, combining field, greenhouse and laboratory experiments, we examined whether local damage triggered systemic responses in undamaged branches that lack vascular connection to the damaged branches, and to what extent this was caused by airborne volatile signals versus internal signals. An experiment tracing dye through the vasculature of saplings revealed no downward movement of the dye from upper to lower branches, suggesting a lack of vascular connectivity among branches. However, we found under both field and laboratory conditions that herbivore feeding on upper branches elicited volatile emissions by undamaged lower branches. Greenhouse experiments manipulating air contact between damaged and undamaged branches showed that systemic induction of volatiles was almost eliminated when air contact was interrupted. Our findings clearly demonstrate that herbivore-induced volatiles overcome vascular constraints and mediate within-plant signaling. Further, we found that volatile signaling led to induction of different classes of volatiles under field and environment controlled conditions, with a weaker response observed in the field. This difference not only reflects the dose- and time-dependent nature of volatile signaling, but also points out that future studies should focus more on field observations to better understand the ecological role of volatile-mediated within-plant signaling.

  11. Fast modified signal-digit (MSD) multiplication technology and system

    Science.gov (United States)

    Sun, DeGui; He, Li-Ming; Wang, Na-Xin; Weng, Zhao-Heng

    1994-06-01

    In this paper, the carry-free property of modified-signed-digit (MSD) addition is analyzed with a space position logic encoding scheme. On this basis, MSD multiplication is discussed and a fast MSD multiplication system composed of optoelectronic logic technology and a multilayer optical interconnection architecture is propsed and studied. Finally, the effectivity of the fast MSD multiplication system is demostrated by using a 2X2 bit multiplication example and experimental results are given.

  12. Energy window selection for a radiation signal processing system

    International Nuclear Information System (INIS)

    Knoll, G.F.; Schrader, M.E.

    1986-01-01

    This invention provides an apparatus and method for selecting only meaningful information from signals produced by Anger-type radioisotope cameras producing positional information. It is an improvement in the means for determining energy threshold values as a function of radiation event positional information. The establishment of an energy threshold table begins by flooding the camera face with a uniform source of radiation and utilizing the pre-established spatial translation table to reposition detected radiation events according to their true spatial element coordinates. A histogram is compiled for each spatial element, the histogram comprising the number of radiation events occurring at several discrete energy levels. A peak centroid value is then determined for each element, and an initial energy window is set. Next, a specified region of the camera field of view is inspected to determine a target sum of radiation events to be accepted by each element, setting a standard for adjusting the energy windows of each element. Using this standard, the energy window for each element is progressively adapted so that each will accept nearly the same number of radiation events or counts in response to a flood or calibration image. Finally the energy window for each true spatial element is translated back to its apparent spatial element and incorporated into an energy threshold table accessible by the apparent spatial coordinates of each radiation event

  13. Automated Measurement and Signaling Systems for the Transactional Network

    Energy Technology Data Exchange (ETDEWEB)

    Piette, Mary Ann; Brown, Richard; Price, Phillip; Page, Janie; Granderson, Jessica; Riess, David; Czarnecki, Stephen; Ghatikar, Girish; Lanzisera, Steven

    2013-12-31

    The Transactional Network Project is a multi-lab activity funded by the US Department of Energy?s Building Technologies Office. The project team included staff from Lawrence Berkeley National Laboratory, Pacific Northwest National Laboratory and Oak Ridge National Laboratory. The team designed, prototyped and tested a transactional network (TN) platform to support energy, operational and financial transactions between any networked entities (equipment, organizations, buildings, grid, etc.). PNNL was responsible for the development of the TN platform, with agents for this platform developed by each of the three labs. LBNL contributed applications to measure the whole-building electric load response to various changes in building operations, particularly energy efficiency improvements and demand response events. We also provide a demand response signaling agent and an agent for cost savings analysis. LBNL and PNNL demonstrated actual transactions between packaged rooftop units and the electric grid using the platform and selected agents. This document describes the agents and applications developed by the LBNL team, and associated tests of the applications.

  14. An innovative non-intrusive driver assistance system for vital signal monitoring.

    NARCIS (Netherlands)

    Sun, Y. & Yu, X.

    2016-01-01

    This paper describes an in-vehicle nonintrusive biopotential measurement system for driver health monitoring and fatigue detection. Previous research has found that the physiological signals including eye features, electrocardiography (ECG), electroencephalography (EEG) and their secondary

  15. Training-based Channel Estimation for Signal Equalization and OPM in 16-QAM Optical Transmission Systems

    DEFF Research Database (Denmark)

    Pittalà, Fabio; Hauske, Fabian N.; Ye, Yabin

    2012-01-01

    Efficient channel estimation for signal equalization and OPM based on short CAZAC sequences with QPSK and 8PSK constellation formats is demonstrated in a 224-Gb/s PDM 16-QAM optical linear transmission system....

  16. Permanency analysis on human electroencephalogram signals for pervasive Brain-Computer Interface systems.

    Science.gov (United States)

    Sadeghi, Koosha; Junghyo Lee; Banerjee, Ayan; Sohankar, Javad; Gupta, Sandeep K S

    2017-07-01

    Brain-Computer Interface (BCI) systems use some permanent features of brain signals to recognize their corresponding cognitive states with high accuracy. However, these features are not perfectly permanent, and BCI system should be continuously trained over time, which is tedious and time consuming. Thus, analyzing the permanency of signal features is essential in determining how often to repeat training. In this paper, we monitor electroencephalogram (EEG) signals, and analyze their behavior through continuous and relatively long period of time. In our experiment, we record EEG signals corresponding to rest state (eyes open and closed) from one subject everyday, for three and a half months. The results show that signal features such as auto-regression coefficients remain permanent through time, while others such as power spectral density specifically in 5-7 Hz frequency band are not permanent. In addition, eyes open EEG data shows more permanency than eyes closed data.

  17. 49 CFR 236.401 - Automatic block signal system and interlocking standards applicable to traffic control systems.

    Science.gov (United States)

    2010-10-01

    ... TRAIN CONTROL SYSTEMS, DEVICES, AND APPLIANCES Traffic Control Systems Standards § 236.401 Automatic... 49 Transportation 4 2010-10-01 2010-10-01 false Automatic block signal system and interlocking standards applicable to traffic control systems. 236.401 Section 236.401 Transportation Other Regulations...

  18. Electromagnetic Signal Feedback Control for Proximity Detection Systems

    Science.gov (United States)

    Smith, Adam K.

    Coal is the most abundant fossil fuel in the United States and remains an essential source of energy. While more than half of coal production comes from surface mining, nearly twice as many workers are employed by underground operations. One of the key pieces of equipment used in underground coal mining is the continuous mining machine. These large and powerful machines are operated in confined spaces by remote control. Since 1984, 40 mine workers in the U. S. have been killed when struck or pinned by a continuous mining machine. It is estimated that a majority of these accidents could have been prevented with the application of proximity detection systems. While proximity detection systems can significantly increase safety around a continuous mining machine, there are some system limitations. Commercially available proximity warning systems for continuous mining machines use magnetic field generators to detect workers and establish safe work areas around the machines. Several environmental factors, however, can influence and distort the magnetic fields. To minimize these effects, a control system has been developed using electromagnetic field strength and generator current to stabilize and control field drift induced by internal and external environmental factors. A laboratory test set-up was built using a ferrite-core magnetic field generator to produce a stable magnetic field. Previous work based on a field-invariant magnetic flux density model, which generically describes the electromagnetic field, is expanded upon. The analytically established transferable shell-based flux density distribution model is used to experimentally validate the control system. By controlling the current input to the ferrite-core generator, a more reliable and consistent magnetic field is produced. Implementation of this technology will improve accuracy and performance of existing commercial proximity detection systems. These research results will help reduce the risk of traumatic

  19. Practical Consideration Factors to Design Array Configuration of Direction Finding System for Airborne Signal Intelligence

    Directory of Open Access Journals (Sweden)

    Jong-Hwan Lee

    2018-01-01

    Full Text Available Airborne signal intelligence (SIGINT systems must be capable of locating radio signal sources. Direction finding (DF to support this capability is an important factor. There are some practical considerations to be taken when designing the array configuration of a DF system for airborne SIGINT systems. This paper summarizes the practical factors when designing the array configuration of the DF system for airborne SIGINT. In particular, it focuses on four areas: antenna consideration factors when installing the DF system for airborne SIGINT from a practical point of view, array configuration methods for airborne communications intelligence and electronic intelligence, and a numerical analysis to select the optimum antenna position for airborne SIGINT.

  20. Operation and performance of a longitudinal feedback system using digital signal processing

    International Nuclear Information System (INIS)

    Teytelman, D.; Fox, J.; Hindi, H.

    1994-01-01

    A programmable longitudinal feedback system using a parallel array of AT ampersand T 1610 digital signal processors has been developed as a component of the PEP-II R ampersand D program. This system has been installed at the Advanced Light Source (LBL) and implements full speed bunch by bunch signal processing for storage rings with bunch spacing of 4ns. Open and closed loop results showing the action of the feedback system are presented, and the system is shown to damp coupled-bunch instabilities in the ALS. A unified PC-based software environment for the feedback system operation is also described

  1. Optimizing a Synthetic Signaling System, Using Mathematical Modeling to Direct Experimental Work

    Science.gov (United States)

    2014-09-05

    arsenic , toluene, lead, DDT, mercury, etc.). The synthetic signaling system then be used to trigger a phytoremediation process upon detection of these...transferred to soil and allowed to set seed. The T1 generation will yield plants heterozygous and homozygous for the synthetic signaling system, allowing...compounds, either by breaking them down or transporting them to the aerial tissue where they can be harvested and removed from the soil

  2. Batteryless wireless transmission system for electronic drum uses piezoelectric generator for play signal and power source

    International Nuclear Information System (INIS)

    Nishikawa, H; Yoshimi, A; Takemura, K; Tanaka, A; Douseki, T

    2015-01-01

    A batteryless self-powered wireless transmission system has been developed that sends a signal from a drum pad to a synthesizer. The power generated by a piezoelectric generator functions both as the “Play” signal for the synthesizer and as the power source for the transmitter. An FM transmitter, which theoretically operates with zero latency, and a receiver with quick-response squelch of the received signal were developed for wireless transmission with a minimum system delay. Experimental results for an electronic drum without any connecting wires fully demonstrated the feasibility of self-powered wireless transmission with a latency of 900 μs. (paper)

  3. Direction of Radio Finding via MUSIC (Multiple Signal Classification) Algorithm for Hardware Design System

    Science.gov (United States)

    Zhang, Zheng

    2017-10-01

    Concept of radio direction finding systems, which use radio direction finding is based on digital signal processing algorithms. Thus, the radio direction finding system becomes capable to locate and track signals by the both. Performance of radio direction finding significantly depends on effectiveness of digital signal processing algorithms. The algorithm uses the Direction of Arrival (DOA) algorithms to estimate the number of incidents plane waves on the antenna array and their angle of incidence. This manuscript investigates implementation of the DOA algorithms (MUSIC) on the uniform linear array in the presence of white noise. The experiment results exhibit that MUSIC algorithm changed well with the radio direction.

  4. A longitudinal multi-bunch feedback system using parallel digital signal processors

    International Nuclear Information System (INIS)

    Sapozhnikov, L.; Fox, J.D.; Olsen, J.J.; Oxoby, G.; Linscott, I.; Drago, A.; Serio, M.

    1994-01-01

    A programmable longitudinal feedback system based on four AT ampersand T 1610 digital signal processors has been developed as a component of the PEP-II R ampersand D program. This longitudinal quick prototype is a proof of concept for the PEP-II system and implements full-speed bunch-by-bunch signal processing for storage rings with bunch spacings of 4 ns. The design incorporates a phase-detector-based front end that digitizes the oscillation phases of bunches at the 250 MHz crossing rate, four programmable signal processors that compute correction signals, and a 250-MHz hold buffer/kicker driver stage that applies correction signals back on the beam. The design implements a general-purpose, table-driven downsampler that allows the system to be operated at several accelerator facilities. The hardware architecture of the signal processing is described, and the software algorithms used in the feedback signal computation are discussed. The system configuration used for tests at the LBL Advanced Light Source is presented

  5. Stochastic Resonance in an Underdamped System with Pinning Potential for Weak Signal Detection

    Directory of Open Access Journals (Sweden)

    Haibin Zhang

    2015-08-01

    Full Text Available Stochastic resonance (SR has been proved to be an effective approach for weak sensor signal detection. This study presents a new weak signal detection method based on a SR in an underdamped system, which consists of a pinning potential model. The model was firstly discovered from magnetic domain wall (DW in ferromagnetic strips. We analyze the principle of the proposed underdamped pinning SR (UPSR system, the detailed numerical simulation and system performance. We also propose the strategy of selecting the proper damping factor and other system parameters to match a weak signal, input noise and to generate the highest output signal-to-noise ratio (SNR. Finally, we have verified its effectiveness with both simulated and experimental input signals. Results indicate that the UPSR performs better in weak signal detection than the conventional SR (CSR with merits of higher output SNR, better anti-noise and frequency response capability. Besides, the system can be designed accurately and efficiently owing to the sensibility of parameters and potential diversity. The features also weaken the limitation of small parameters on SR system.

  6. Stochastic Resonance in an Underdamped System with Pinning Potential for Weak Signal Detection.

    Science.gov (United States)

    Zhang, Haibin; He, Qingbo; Kong, Fanrang

    2015-08-28

    Stochastic resonance (SR) has been proved to be an effective approach for weak sensor signal detection. This study presents a new weak signal detection method based on a SR in an underdamped system, which consists of a pinning potential model. The model was firstly discovered from magnetic domain wall (DW) in ferromagnetic strips. We analyze the principle of the proposed underdamped pinning SR (UPSR) system, the detailed numerical simulation and system performance. We also propose the strategy of selecting the proper damping factor and other system parameters to match a weak signal, input noise and to generate the highest output signal-to-noise ratio (SNR). Finally, we have verified its effectiveness with both simulated and experimental input signals. Results indicate that the UPSR performs better in weak signal detection than the conventional SR (CSR) with merits of higher output SNR, better anti-noise and frequency response capability. Besides, the system can be designed accurately and efficiently owing to the sensibility of parameters and potential diversity. The features also weaken the limitation of small parameters on SR system.

  7. Feedforward signal prediction for accurate motion systems using digital filters

    NARCIS (Netherlands)

    Butler, H.

    2012-01-01

    A positioning system that needs to accurately track a reference can benefit greatly from using feedforward. When using a force actuator, the feedforward needs to generate a force proportional to the reference acceleration, which can be measured by means of an accelerometer or can be created by

  8. Bacterial Signaling to the Nervous System through Toxins and Metabolites.

    Science.gov (United States)

    Yang, Nicole J; Chiu, Isaac M

    2017-03-10

    Mammalian hosts interface intimately with commensal and pathogenic bacteria. It is increasingly clear that molecular interactions between the nervous system and microbes contribute to health and disease. Both commensal and pathogenic bacteria are capable of producing molecules that act on neurons and affect essential aspects of host physiology. Here we highlight several classes of physiologically important molecular interactions that occur between bacteria and the nervous system. First, clostridial neurotoxins block neurotransmission to or from neurons by targeting the SNARE complex, causing the characteristic paralyses of botulism and tetanus during bacterial infection. Second, peripheral sensory neurons-olfactory chemosensory neurons and nociceptor sensory neurons-detect bacterial toxins, formyl peptides, and lipopolysaccharides through distinct molecular mechanisms to elicit smell and pain. Bacteria also damage the central nervous system through toxins that target the brain during infection. Finally, the gut microbiota produces molecules that act on enteric neurons to influence gastrointestinal motility, and metabolites that stimulate the "gut-brain axis" to alter neural circuits, autonomic function, and higher-order brain function and behavior. Furthering the mechanistic and molecular understanding of how bacteria affect the nervous system may uncover potential strategies for modulating neural function and treating neurological diseases. Copyright © 2017 Elsevier Ltd. All rights reserved.

  9. Developing resilience signals for the Dutch railway system

    NARCIS (Netherlands)

    Siegel, A.W.; Schraagen, Johannes Martinus Cornelis; Herrera, I.; Schraagen, J.M.C.; van der Vorm, J.; Woods, D.D.

    2014-01-01

    A resilience state model for a railway system is proposed consisting of three boundaries putting pressure on the operating state: Safety, Performance (Capacity & Punctuality) and Workload. In order to model the pressure of the boundaries, an additional dimension is added where the slope represents

  10. Algorithms for Indoor Positioning Systems Using Ultra-Wideband Signals

    NARCIS (Netherlands)

    Yan, J.

    2010-01-01

    Positioning systems and techniques have attracted more and more attention in recent years, in particular with satellite navigation technology as a tremendous enabler, and developments in indoor navigation. The work presented in this thesis has been conducted within the research project: \\HERE:

  11. Sphingosine-1-phosphate signaling in the cardiovascular system

    NARCIS (Netherlands)

    Peters, Stephan L. M.; Alewijnse, Astrid E.

    2007-01-01

    Increasing evidence suggests a key role for the bioactive lipid sphingosine-1-phosphate (S1P) and its G-protein-coupled receptors (S1P(1-5)) in the cardiovascular system. Recent advances in sphingolipid research indicates that cardiomyocyte, vascular smooth muscle and endothelial cell function is

  12. Signal Processing Methods for Flood Early Warning Systems

    NARCIS (Netherlands)

    Pyayt, A.L.; Mokhov, I.I.; Kozionov, A.P.; Kusherbaeva, V.T.; Krzhizhanovskaya, V.V.; Broekhuijsen, B.J.; Meijer, R.J.; Hinkelmann, R.; Nasermoaddeli, M.H.; Liong, S.Y.; Savic, D.; Fröhle, P.; Daemrich, K.F.

    2012-01-01

    We present in a data-driven approach for detection of anomalies in earthen dam (dike) behaviour that can indicate the onset of flood defence structure failure. This approach is implemented in the UrbanFlood early warning system's Artificial Intelligence component that processes dike measurements in

  13. Intelligent Automatic Right-Left Sign Lamp Based on Brain Signal Recognition System

    Science.gov (United States)

    Winda, A.; Sofyan; Sthevany; Vincent, R. S.

    2017-12-01

    Comfort as a part of the human factor, plays important roles in nowadays advanced automotive technology. Many of the current technologies go in the direction of automotive driver assistance features. However, many of the driver assistance features still require physical movement by human to enable the features. In this work, the proposed method is used in order to make certain feature to be functioning without any physical movement, instead human just need to think about it in their mind. In this work, brain signal is recorded and processed in order to be used as input to the recognition system. Right-Left sign lamp based on the brain signal recognition system can potentially replace the button or switch of the specific device in order to make the lamp work. The system then will decide whether the signal is ‘Right’ or ‘Left’. The decision of the Right-Left side of brain signal recognition will be sent to a processing board in order to activate the automotive relay, which will be used to activate the sign lamp. Furthermore, the intelligent system approach is used to develop authorized model based on the brain signal. Particularly Support Vector Machines (SVMs)-based classification system is used in the proposed system to recognize the Left-Right of the brain signal. Experimental results confirm the effectiveness of the proposed intelligent Automatic brain signal-based Right-Left sign lamp access control system. The signal is processed by Linear Prediction Coefficient (LPC) and Support Vector Machines (SVMs), and the resulting experiment shows the training and testing accuracy of 100% and 80%, respectively.

  14. Operation and performance of a longitudinal damping system using parallel digital signal processing

    International Nuclear Information System (INIS)

    Fox, J.D.; Hindi, H.; Linscott, I.

    1994-06-01

    A programmable longitudinal feedback system based on four AT ampersand T 1610 digital signal processors has been developed as a component of the PEP-II R ampersand D program. This Longitudinal Quick Prototype is a proof of concept for the PEP-II system and implements full speed bunch-by-bunch signal processing for storage rings with bunch spacings of 4 ns. The design implements, via software, a general purpose feedback controller which allows the system to be operated at several accelerator facilities. The system configuration used for tests at the LBL Advanced Light Source is described. Open and closed loop results showing the detection and calculation of feedback signals from bunch motion are presented, and the system is shown to damp coupled-bunch instabilities in the ALS. Use of the system for accelerator diagnostics is illustrated via measurement of injection transients and analysis of open loop bunch motion

  15. Assessment of uniformity and signal-to-noise ratio in radiological image intensifier TV systems

    International Nuclear Information System (INIS)

    Malone, J.F.; O'Connor, M.K.; Maher, K.P.

    1985-01-01

    A method of measuring the uniformity of radiological Image Intensifier-TV systems is described. Large non-uniformities were observed in the systems tested. A method of estimating the Signal-to-Noise Ratio in such systems is also presented and applied to characterise the effectiveness of the noise reduction techniques used in digital fluoroscopy. (author)

  16. Lag synchronization of Rossler system and Chua circuit via a scalar signal

    International Nuclear Information System (INIS)

    Li Chuandong; Liao Xiaofeng

    2004-01-01

    In this Letter, a chaotic lag synchronization scheme is proposed based on combining a nonlinear with lag-in-time observer design. Our approach leads to a systematic methodology, which guarantees the synchronization of a wide class of chaotic systems via a scalar signal. The proposed technique has been applied to synchronize two well-known chaotic systems: Rossler's system and Chua circuit

  17. Reconfigurable signal processor designs for advanced digital array radar systems

    Science.gov (United States)

    Suarez, Hernan; Zhang, Yan (Rockee); Yu, Xining

    2017-05-01

    The new challenges originated from Digital Array Radar (DAR) demands a new generation of reconfigurable backend processor in the system. The new FPGA devices can support much higher speed, more bandwidth and processing capabilities for the need of digital Line Replaceable Unit (LRU). This study focuses on using the latest Altera and Xilinx devices in an adaptive beamforming processor. The field reprogrammable RF devices from Analog Devices are used as analog front end transceivers. Different from other existing Software-Defined Radio transceivers on the market, this processor is designed for distributed adaptive beamforming in a networked environment. The following aspects of the novel radar processor will be presented: (1) A new system-on-chip architecture based on Altera's devices and adaptive processing module, especially for the adaptive beamforming and pulse compression, will be introduced, (2) Successful implementation of generation 2 serial RapidIO data links on FPGA, which supports VITA-49 radio packet format for large distributed DAR processing. (3) Demonstration of the feasibility and capabilities of the processor in a Micro-TCA based, SRIO switching backplane to support multichannel beamforming in real-time. (4) Application of this processor in ongoing radar system development projects, including OU's dual-polarized digital array radar, the planned new cylindrical array radars, and future airborne radars.

  18. A probablistic neural network classification system for signal and image processing

    Energy Technology Data Exchange (ETDEWEB)

    Bowman, B. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    The Acoustical Heart Valve Analysis Package is a system for signal and image processing and classification. It is being developed in both Matlab and C, to provide an interactive, interpreted environment, and has been optimized for large scale matrix operations. It has been used successfully to classify acoustic signals from implanted prosthetic heart valves in human patients, and will be integrated into a commercial Heart Valve Screening Center. The system uses several standard signal processing algorithms, as well as supervised learning techniques using the probabilistic neural network (PNN). Although currently used for the acoustic heart valve application, the algorithms and modular design allow it to be used for other applications, as well. We will describe the signal classification system, and show results from a set of test valves.

  19. Data-derived symbol synchronization of MASK and QASK signals. [for multilevel digital communication systems

    Science.gov (United States)

    Simon, M. K.

    1974-01-01

    Multilevel amplitude-shift-keying (MASK) and quadrature amplitude-shift-keying (QASK) as signaling techniques for multilevel digital communications systems, and the problem of providing symbol synchronization in the receivers of such systems are discussed. A technique is presented for extracting symbol sync from an MASK or QASK signal. The scheme is a generalization of the data transition tracking loop used in PSK systems. The performance of the loop was analyzed in terms of its mean-squared jitter and its effects on the data detection process in MASK and QASK systems.

  20. A Review on the Nonlinear Dynamical System Analysis of Electrocardiogram Signal.

    Science.gov (United States)

    Nayak, Suraj K; Bit, Arindam; Dey, Anilesh; Mohapatra, Biswajit; Pal, Kunal

    2018-01-01

    Electrocardiogram (ECG) signal analysis has received special attention of the researchers in the recent past because of its ability to divulge crucial information about the electrophysiology of the heart and the autonomic nervous system activity in a noninvasive manner. Analysis of the ECG signals has been explored using both linear and nonlinear methods. However, the nonlinear methods of ECG signal analysis are gaining popularity because of their robustness in feature extraction and classification. The current study presents a review of the nonlinear signal analysis methods, namely, reconstructed phase space analysis, Lyapunov exponents, correlation dimension, detrended fluctuation analysis (DFA), recurrence plot, Poincaré plot, approximate entropy, and sample entropy along with their recent applications in the ECG signal analysis.

  1. A Review on the Nonlinear Dynamical System Analysis of Electrocardiogram Signal

    Science.gov (United States)

    Mohapatra, Biswajit

    2018-01-01

    Electrocardiogram (ECG) signal analysis has received special attention of the researchers in the recent past because of its ability to divulge crucial information about the electrophysiology of the heart and the autonomic nervous system activity in a noninvasive manner. Analysis of the ECG signals has been explored using both linear and nonlinear methods. However, the nonlinear methods of ECG signal analysis are gaining popularity because of their robustness in feature extraction and classification. The current study presents a review of the nonlinear signal analysis methods, namely, reconstructed phase space analysis, Lyapunov exponents, correlation dimension, detrended fluctuation analysis (DFA), recurrence plot, Poincaré plot, approximate entropy, and sample entropy along with their recent applications in the ECG signal analysis. PMID:29854361

  2. Man-Machine Interface System for Neuromuscular Training and Evaluation Based on EMG and MMG Signals

    Directory of Open Access Journals (Sweden)

    Patricia Fernández

    2010-12-01

    Full Text Available This paper presents the UVa-NTS (University of Valladolid Neuromuscular Training System, a multifunction and portable Neuromuscular Training System. The UVa-NTS is designed to analyze the voluntary control of severe neuromotor handicapped patients, their interactive response, and their adaptation to neuromuscular interface systems, such as neural prostheses or domotic applications. Thus, it is an excellent tool to evaluate the residual muscle capabilities in the handicapped. The UVa-NTS is composed of a custom signal conditioning front-end and a computer. The front-end electronics is described thoroughly as well as the overall features of the custom software implementation. The software system is composed of a set of graphical training tools and a processing core. The UVa-NTS works with two classes of neuromuscular signals: the classic myoelectric signals (MES and, as a novelty, the myomechanic signals (MMS. In order to evaluate the performance of the processing core, a complete analysis has been done to classify its efficiency and to check that it fulfils with the real-time constraints. Tests were performed both with healthy and selected impaired subjects. The adaptation was achieved rapidly, applying a predefined protocol for the UVa-NTS set of training tools. Fine voluntary control was demonstrated to be reached with the myoelectric signals. And the UVa-NTS demonstrated to provide a satisfactory voluntary control when applying the myomechanic signals.

  3. A New Position Location System Using DTV Transmitter Identification Watermark Signals

    Directory of Open Access Journals (Sweden)

    Chouinard Jean-Yves

    2006-01-01

    Full Text Available A new position location technique using the transmitter identification (TxID RF watermark in the digital TV (DTV signals is proposed in this paper. Conventional global positioning system (GPS usually does not work well inside buildings due to the high frequency and weak field strength of the signal. In contrast to the GPS, the DTV signals are received from transmitters at relatively short distance, while the broadcast transmitters operate at levels up to the megawatts effective radiated power (ERP. Also the RF frequency of the DTV signal is much lower than the GPS, which makes it easier for the signal to penetrate buildings and other objects. The proposed position location system based on DTV TxID signal is presented in this paper. Practical receiver implementation issues including nonideal correlation and synchronization are analyzed and discussed. Performance of the proposed technique is evaluated through Monte Carlo simulations and compared with other existing position location systems. Possible ways to improve the accuracy of the new position location system is discussed.

  4. Man-machine interface system for neuromuscular training and evaluation based on EMG and MMG signals.

    Science.gov (United States)

    de la Rosa, Ramon; Alonso, Alonso; Carrera, Albano; Durán, Ramon; Fernández, Patricia

    2010-01-01

    This paper presents the UVa-NTS (University of Valladolid Neuromuscular Training System), a multifunction and portable Neuromuscular Training System. The UVa-NTS is designed to analyze the voluntary control of severe neuromotor handicapped patients, their interactive response, and their adaptation to neuromuscular interface systems, such as neural prostheses or domotic applications. Thus, it is an excellent tool to evaluate the residual muscle capabilities in the handicapped. The UVa-NTS is composed of a custom signal conditioning front-end and a computer. The front-end electronics is described thoroughly as well as the overall features of the custom software implementation. The software system is composed of a set of graphical training tools and a processing core. The UVa-NTS works with two classes of neuromuscular signals: the classic myoelectric signals (MES) and, as a novelty, the myomechanic signals (MMS). In order to evaluate the performance of the processing core, a complete analysis has been done to classify its efficiency and to check that it fulfils with the real-time constraints. Tests were performed both with healthy and selected impaired subjects. The adaptation was achieved rapidly, applying a predefined protocol for the UVa-NTS set of training tools. Fine voluntary control was demonstrated to be reached with the myoelectric signals. And the UVa-NTS demonstrated to provide a satisfactory voluntary control when applying the myomechanic signals.

  5. Signal Detection of Imipenem Compared to Other Drugs from Korea Adverse Event Reporting System Database.

    Science.gov (United States)

    Park, Kyounghoon; Soukavong, Mick; Kim, Jungmee; Kwon, Kyoung Eun; Jin, Xue Mei; Lee, Joongyub; Yang, Bo Ram; Park, Byung Joo

    2017-05-01

    To detect signals of adverse drug events after imipenem treatment using the Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database (KIDS-KD). We performed data mining using KIDS-KD, which was constructed using spontaneously reported adverse event (AE) reports between December 1988 and June 2014. We detected signals calculated the proportional reporting ratio, reporting odds ratio, and information component of imipenem. We defined a signal as any AE that satisfied all three indices. The signals were compared with drug labels of nine countries. There were 807582 spontaneous AEs reports in the KIDS-KD. Among those, the number of antibiotics related AEs was 192510; 3382 reports were associated with imipenem. The most common imipenem-associated AE was the drug eruption; 353 times. We calculated the signal by comparing with all other antibiotics and drugs; 58 and 53 signals satisfied the three methods. We compared the drug labelling information of nine countries, including the USA, the UK, Japan, Italy, Switzerland, Germany, France, Canada, and South Korea, and discovered that the following signals were currently not included in drug labels: hypokalemia, cardiac arrest, cardiac failure, Parkinson's syndrome, myocardial infarction, and prostate enlargement. Hypokalemia was an additional signal compared with all other antibiotics, and the other signals were not different compared with all other antibiotics and all other drugs. We detected new signals that were not listed on the drug labels of nine countries. However, further pharmacoepidemiologic research is needed to evaluate the causality of these signals. © Copyright: Yonsei University College of Medicine 2017

  6. Congestion and flow control in signaling system no. 7: Impacts of intelligent networks and new services

    Science.gov (United States)

    Zepf, Joachim; Rufa, Gerhard

    1994-04-01

    This paper focuses on the transient performance analysis of the congestion and flow control mechanisms in CCITT Signaling System No. 7 (SS7). Special attention is directed to the impacts of the introduction of intelligent services and new applications, e.g., Freephone, credit card services, user-to-user signaling, etc. In particular, we show that signaling traffic characteristics like signaling scenarios or signaling message length as well as end-to-end signaling capabilities have a significant influence on the congestion and flow control and, therefore, on the real-time signaling performance. One important result of our performance studies is that if, e.g., intelligent services are introduced, the SS7 congestion and flow control does not work correctly. To solve this problem, some reinvestigations into these mechanisms would be necessary. Therefore, some approaches, e.g., modification of the Signaling Connection Control Part (SCCP) congestion control, usage of the SCCP relay function, or a redesign of the MTP flow control procedures are discussed in order to guarantee the efficacy of the congestion and flow control mechanisms also in the future.

  7. Molecular evolution of peptidergic signaling systems in bilaterians

    Science.gov (United States)

    Mirabeau, Olivier; Joly, Jean-Stéphane

    2013-01-01

    Peptide hormones and their receptors are widespread in metazoans, but the knowledge we have of their evolutionary relationships remains unclear. Recently, accumulating genome sequences from many different species have offered the opportunity to reassess the relationships between protostomian and deuterostomian peptidergic systems (PSs). Here we used sequences of all human rhodopsin and secretin-type G protein-coupled receptors as bait to retrieve potential homologs in the genomes of 15 bilaterian species, including nonchordate deuterostomian and lophotrochozoan species. Our phylogenetic analysis of these receptors revealed 29 well-supported subtrees containing mixed sets of protostomian and deuterostomian sequences. This indicated that many vertebrate and arthropod PSs that were previously thought to be phyla specific are in fact of bilaterian origin. By screening sequence databases for potential peptides, we then reconstructed entire bilaterian peptide families and showed that protostomian and deuterostomian peptides that are ligands of orthologous receptors displayed some similarity at the level of their primary sequence, suggesting an ancient coevolution between peptide and receptor genes. In addition to shedding light on the function of human G protein-coupled receptor PSs, this work presents orthology markers to study ancestral neuron types that were probably present in the last common bilaterian ancestor. PMID:23671109

  8. Light relations and performance of signal grass in silvopastoral system

    Directory of Open Access Journals (Sweden)

    Cynara Oliveira Diniz Rodrigues

    2014-03-01

    Full Text Available The aim was to evaluate the influence of different spatial arrangements of trees [(3×2×20 m, (2×2×9 m and 2×9 m] and sampling sites (center of row spacing and side of tree rows with regard to the amount and quality of light in the understory of silvopastoral systems and their effects on the production and chemical composition of pasture. The experimental design was a randomized block in a split plot, with three replications. The sampling site affected absolute irradiance, photosynthetic active radiation (PAR, light interception (LI and red/far red ratio, with higher rates in the center of spacing. There were high and positive correlations between LI/leaf area index (LAI, LI/dry mater (DM and LAI/DM in the center and LI/LAI and FAR/DM in the side of tree rows. Spatial arrangement (3×2×20 m had higher rates for plant height (PH, DM and neutral detergent fiber rate, while (2×2×9 m had high leaf/stem ratio and crude protein rate. In the case of the sampling site, higher rates of PH and DM were reported in the center. Forage composition was not affected by sampling sites. Highest production of DM was obtained in the (3×2×20 m arrangement and improvements in forage composition were observed in denser arrangements.

  9. ANN-based wavelet analysis for predicting electrical signal from photovoltaic power supply system

    Energy Technology Data Exchange (ETDEWEB)

    Mellit, A. [Medea Univ., Medea (Algeria). Inst. of Science Engineering, Dept. of Electronics

    2007-07-01

    This study was conducted to predict different electrical signals from a photovoltaic power supply system (PVPS) using an artificial neural networks (ANN) with wavelet analysis. It involved the creation of a database of electrical signals (PV-generator current, voltage, battery current voltage, regulator current and voltage) obtained from an experimental PVPS system installed in the south of Algeria. The potential applications were for sizing and analyzing the performance of PVPS systems; control of maximum power point tracker (MPPT) in order to deliver the maximum energy from the PV-array; prediction of the optimal configuration (PV-array and battery sizing) of PVPS systems; expert configuration of PV-systems; faults diagnosis; supervision; and, control and monitoring. First, based on the wavelet analysis each electrical signal was mapped in several time frequency domains. The PV-system was then divided into 3-subsystems corresponding to ANN-PV generator model, ANN-battery model, and ANN-regulator model. An example of day-by-day prediction for each electrical signal was presented. The results of the proposed approach were in good agreement with experimental results. In addition, the accuracy of the proposed approach was more satisfactory when only ANN was used. It was concluded that this methodology offers the possibility of developing a new expert configuration of PVPS by implementing the soft computing ANN-wavelet program with a digital signal processing (DSP) circuit. 26 refs., 1 tab., 5 figs.

  10. The regulatory function of self-esteem: testing the epistemic and acceptance signaling systems.

    Science.gov (United States)

    Stinson, Danu Anthony; Logel, Christine; Holmes, John G; Wood, Joanne V; Forest, Amanda L; Gaucher, Danielle; Fitzsimons, Grainné M; Kath, Jennifer

    2010-12-01

    The authors draw on sociometer theory (e.g., Leary, 2004) and self-verification theory (e.g., Swann, 1997) to propose an expanded model of the regulatory function of self-esteem. The model suggests that people not only possess an acceptance signaling system that indicates whether relational value is high or low but also possess an epistemic signaling system that indicates whether social feedback is consistent or inconsistent with chronic perceived relational value (i.e., global self-esteem). One correlational study and 5 experiments, with diverse operationalizations of social feedback, demonstrated that the epistemic signaling system responds to self-esteem consistent or inconsistent relational-value feedback with increases or deceases in epistemic certainty. Moreover, Studies 3-6 demonstrated that the acceptance and epistemic signaling systems respond uniquely to social feedback. Finally, Studies 5 and 6 provide evidence that the epistemic signaling system is part of a broader self-regulatory system: Self-esteem inconsistent feedback caused cognitive efforts to decrease the discrepancy between self-views and feedback and caused depleted self-regulatory capacity on a subsequent self-control task. PsycINFO Database Record (c) 2010 APA, all rights reserved.

  11. Large-signal analysis of DC motor drive system using state-space averaging technique

    International Nuclear Information System (INIS)

    Bekir Yildiz, Ali

    2008-01-01

    The analysis of a separately excited DC motor driven by DC-DC converter is realized by using state-space averaging technique. Firstly, a general and unified large-signal averaged circuit model for DC-DC converters is given. The method converts power electronic systems, which are periodic time-variant because of their switching operation, to unified and time independent systems. Using the averaged circuit model enables us to combine the different topologies of converters. Thus, all analysis and design processes about DC motor can be easily realized by using the unified averaged model which is valid during whole period. Some large-signal variations such as speed and current relating to DC motor, steady-state analysis, large-signal and small-signal transfer functions are easily obtained by using the averaged circuit model

  12. Underlay Cognitive Radio Systems with Improper Gaussian Signaling: Outage Performance Analysis

    KAUST Repository

    Amin, Osama

    2016-03-29

    Improper Gaussian signaling has the ability over proper (conventional) Gaussian signaling to improve the achievable rate of systems that suffer from interference. In this paper, we study the impact of using improper Gaussian signaling on the performance limits of the underlay cognitive radio system by analyzing the achievable outage probability of both the primary user (PU) and secondary user (SU). We derive the exact outage probability expression of the SU and construct upper and lower bounds of the PU outage probability which results in formulating an approximate expression of the PU outage probability. This allows us to design the SU signal by adjusting its transmitted power and the circularity coefficient to minimize the SU outage probability while maintaining a certain PU quality-of-service. Finally, we evaluate the derived expressions for both the SU and the PU and the corresponding adaptive algorithms by numerical results.

  13. A simple-architecture fibered transmission system for dissemination of high stability 100 MHz signals

    Science.gov (United States)

    Bakir, A.; Rocher, C.; Maréchal, B.; Bigler, E.; Boudot, R.; Kersalé, Y.; Millo, J.

    2018-05-01

    We report on the development of a simple-architecture fiber-based frequency distribution system used to transfer high frequency stability 100 MHz signals. This work is focused on the emitter and the receiver performances that allow the transmission of the radio-frequency signal over an optical fiber. The system exhibits a residual fractional frequency stability of 1 × 10-14 at 1 s integration time and in the low 10-16 range after 100 s. These performances are suitable to transfer the signal of frequency references such as those of a state-of-the-art hydrogen maser without any phase noise compensation scheme. As an application, we demonstrate the dissemination of such a signal through a 100 m long optical fiber without any degradation. The proposed setup could be easily extended for operating frequencies in the 10 MHz-1 GHz range.

  14. Underlay Cognitive Radio Systems with Improper Gaussian Signaling: Outage Performance Analysis

    KAUST Repository

    Amin, Osama; Abediseid, Walid; Alouini, Mohamed-Slim

    2016-01-01

    Improper Gaussian signaling has the ability over proper (conventional) Gaussian signaling to improve the achievable rate of systems that suffer from interference. In this paper, we study the impact of using improper Gaussian signaling on the performance limits of the underlay cognitive radio system by analyzing the achievable outage probability of both the primary user (PU) and secondary user (SU). We derive the exact outage probability expression of the SU and construct upper and lower bounds of the PU outage probability which results in formulating an approximate expression of the PU outage probability. This allows us to design the SU signal by adjusting its transmitted power and the circularity coefficient to minimize the SU outage probability while maintaining a certain PU quality-of-service. Finally, we evaluate the derived expressions for both the SU and the PU and the corresponding adaptive algorithms by numerical results.

  15. Stochastic resonance in a stochastic bistable system with additive noises and square–wave signal

    International Nuclear Information System (INIS)

    Feng, Guo; Xiang-Dong, Luo; Shao-Fu, Li; Yu-Rong, Zhou

    2010-01-01

    This paper considers the stochastic resonance in a stochastic bistable system driven by a periodic square-wave signal and a static force as well as by additive white noise and dichotomous noise from the viewpoint of signal-to-noise ratio. It finds that the signal-to-noise ratio appears as stochastic resonance behaviour when it is plotted as a function of the noise strength of the white noise and dichotomous noise, as a function of the system parameters, or as a function of the static force. Moreover, the influence of the strength of the stochastic potential force and the correlation rate of the dichotomous noise on the signal-to-noise ratio is investigated. (general)

  16. MMSE-based algorithm for joint signal detection, channel and noise variance estimation for OFDM systems

    CERN Document Server

    Savaux, Vincent

    2014-01-01

    This book presents an algorithm for the detection of an orthogonal frequency division multiplexing (OFDM) signal in a cognitive radio context by means of a joint and iterative channel and noise estimation technique. Based on the minimum mean square criterion, it performs an accurate detection of a user in a frequency band, by achieving a quasi-optimal channel and noise variance estimation if the signal is present, and by estimating the noise level in the band if the signal is absent. Organized into three chapters, the first chapter provides the background against which the system model is pr

  17. Systems and methods for remote long standoff biometric identification using microwave cardiac signals

    Science.gov (United States)

    McGrath, William R. (Inventor); Talukder, Ashit (Inventor)

    2012-01-01

    Systems and methods for remote, long standoff biometric identification using microwave cardiac signals are provided. In one embodiment, the invention relates to a method for remote biometric identification using microwave cardiac signals, the method including generating and directing first microwave energy in a direction of a person, receiving microwave energy reflected from the person, the reflected microwave energy indicative of cardiac characteristics of the person, segmenting a signal indicative of the reflected microwave energy into a waveform including a plurality of heart beats, identifying patterns in the microwave heart beats waveform, and identifying the person based on the identified patterns and a stored microwave heart beats waveform.

  18. An open-loop system design for deep space signal processing applications

    Science.gov (United States)

    Tang, Jifei; Xia, Lanhua; Mahapatra, Rabi

    2018-06-01

    A novel open-loop system design with high performance is proposed for space positioning and navigation signal processing. Divided by functions, the system has four modules, bandwidth selectable data recorder, narrowband signal analyzer, time-delay difference of arrival estimator and ANFIS supplement processor. A hardware-software co-design approach is made to accelerate computing capability and improve system efficiency. Embedded with the proposed signal processing algorithms, the designed system is capable of handling tasks with high accuracy over long period of continuous measurements. The experiment results show the Doppler frequency tracking root mean square error during 3 h observation is 0.0128 Hz, while the TDOA residue analysis in correlation power spectrum is 0.1166 rad.

  19. Stochastic resonance in a bistable system subject to multi-time-delayed feedback and aperiodic signal

    International Nuclear Information System (INIS)

    Li Jianlong; Zeng Lingzao

    2010-01-01

    We discuss in detail the effects of the multi-time-delayed feedback driven by an aperiodic signal on the output of a stochastic resonance (SR) system. The effective potential function and dynamical probability density function (PDF) are derived. To measure the performance of the SR system in the presence of a binary random signal, the bit error rate (BER) defined by the dynamical PDF is employed, as is commonly used in digital communications. We find that the delay time, strength of the feedback, and number of time-delayed terms can change the effective potential function and the effective amplitude of the signal, and then affect the BER of the SR system. The numerical simulations strongly support the theoretical results. The goal of this investigation is to explore the effects of the multi-time-delayed feedback on SR and give a guidance to nonlinear systems in the application of information processing.

  20. Small Signal Stability Improvement of Power Systems Using Optimal Load Responses in Competitive Electricity Markets

    DEFF Research Database (Denmark)

    Hu, Weihao; Su, Chi; Chen, Zhe

    2011-01-01

    Since the hourly spot market price is available one day ahead in Denmark, the price could be transferred to the consumers and they may shift some of their loads from high price periods to the low price periods in order to save their energy costs. The optimal load response to an electricity price...... price is proposed. A 17-bus power system with high wind power penetrations, which resembles the Eastern Danish power system, is chosen as the study case. Simulation results show that the optimal load response to electricity prices is an effective measure to improve the small signal stability of power...... for demand side management generates different load profiles and may provide an opportunity to improve the small signal stability of power systems with high wind power penetrations. In this paper, the idea of power system small signal stability improvement by using optimal load response to the electricity...

  1. Impulsive synchronization of Roessler systems with parameter driven by an external signal

    International Nuclear Information System (INIS)

    Zhang Rong; Hu Manfeng; Xu Zhenyuan

    2007-01-01

    In this Letter, an impulsive control scheme is presented to control two uncoupled identical Roessler systems. By driving the parameter of Roessler systems using external chaotic signal or periodic signal, chaotic synchronization and periodic synchronization can be implemented. This is a special impulsive control, but by using the existing results of impulsive control theory, a less conservative estimation of the upper bound of the impulse interval is given, which can guarantee the global asymptotical stability for the impulsive synchronization of Roessler systems. Numerical results are in accord with our estimation

  2. Evaluation of bistable systems versus matched filters in detecting bipolar pulse signals

    OpenAIRE

    Duan, Fabing; Abbott, Derek; Gao, Qisheng

    2004-01-01

    This paper presents a thorough evaluation of a bistable system versus a matched filter in detecting bipolar pulse signals. The detectability of the bistable system can be optimized by adding noise, i.e. the stochastic resonance (SR) phenomenon. This SR effect is also demonstrated by approximate statistical detection theory of the bistable system and corresponding numerical simulations. Furthermore, the performance comparison results between the bistable system and the matched filter show that...

  3. Failure Diagnosis System for a Ball-Screw by Using Vibration Signals

    Directory of Open Access Journals (Sweden)

    Won Gi Lee

    2015-01-01

    Full Text Available Recently, in order to reduce high maintenance costs and to increase operating ratio in manufacturing systems, condition-based maintenance (CBM has been developed. CBM is carried out with indicators, which show equipment’s faults and performance deterioration. In this study, indicator signal acquisition and condition monitoring are applied to a ball-screw-driven stage. Although ball-screw is a typical linearly reciprocating part and is widely used in industry, it has not gained attention to be diagnosed compared to rotating parts such as motor, pump, and bearing. First, the vibration-based monitoring method, which uses vibration signal to monitor the condition of a machine, is proposed. Second, Wavelet transform is used to analyze the defect signals in time-frequency domain. Finally, the failure diagnosis system is developed using the analysis, and then its performance is evaluated. Using the system, we estimated the severity of failure and detect the defect position. The low defect frequency (≈58.7 Hz is spread all over the time in the Wavelet-filtered signal with low frequency range. Its amplitude reflects the progress of defect. The defect position was found in the signal with high frequency range (768~1,536 Hz. It was detected from the interval between abrupt changes of signal.

  4. Omnidirectional regeneration (ODR) of proximity sensor signals for robust diagnosis of journal bearing systems

    Science.gov (United States)

    Jung, Joon Ha; Jeon, Byung Chul; Youn, Byeng D.; Kim, Myungyon; Kim, Donghwan; Kim, Yeonwhan

    2017-06-01

    Some anomaly states of journal bearing rotor systems are direction-oriented (e.g., rubbing, misalignment). In these situations, vibration signals vary according to the direction of the sensors and the health state. This makes diagnosis difficult with traditional diagnosis methods. This paper proposes an omnidirectional regeneration method to develop a robust diagnosis algorithm for rotor systems. The proposed method can generate vibration signals in arbitrary directions without using extra sensors. In this method, signals are generated around the entire circumference of the rotor to consider all possible directions. Then, the directionality of each state is proved by mathematically and is evaluated using a proposed metric. When a directional state is determined, the classification is carried out on all of the generated signals. When a non-directional state is found, the classification is performed on only one of the generated signals to minimize computational load without sacrificing accuracy. The proposed ODR method was validated using experimental data. The classification results show that the proposed method generally outperforms the conventional classification method. The results support the proposed concept of using ODR signals in diagnosis procedures for journal bearing systems.

  5. An ECG Lab Project for Teaching Signal Conditioning Systems in a Master's Degree in Mechatronic Engineering

    Science.gov (United States)

    Martín, Francisco Javier Ferrero; Martínez, Alberto López; Llopis, Marta Valledor; Rodriguez, Juan Carlos Campo; Viejo, Cecilio Blanco; Vershinin, Yuri A.

    2015-01-01

    Ongoing technological progress in measurement systems triggered the development of an in­novative, hands-on teaching program to help students toward a fuller understanding of recent changes in the field. This paper presents a lab project that links theoretical principles with the practical issues of signal conditioning systems. This is…

  6. Digital signal processing in ultrasonic based navigation system for mobile robots

    Directory of Open Access Journals (Sweden)

    Stączek Paweł

    2017-01-01

    Full Text Available A system for estimating the coordinates of automated guided vehicles (AGV was presented in this article. Ultrasonic waves for distance measurement were applied. Used hardware was characterised, as well as signal processing algorithms. The system was tested on wheeled mobile robot in model 2D environment. The results of working range and errors of position estimation were discussed.

  7. Advanced signal processing theory and implementation for sonar, radar, and non-invasive medical diagnostic systems

    CERN Document Server

    Stergiopoulos, Stergios

    2009-01-01

    Integrates topics of signal processing from sonar, radar, and medical system technologies by identifying their concept similarities. This book covers non-invasive medical diagnostic system applications, including intracranial ultrasound, a technology that attempts to address non-invasive detection on brain injuries and stroke.

  8. A Hybrid Fuzzy Genetic Algorithm for an Adaptive Traffic Signal System

    Directory of Open Access Journals (Sweden)

    S. M. Odeh

    2015-01-01

    Full Text Available This paper presents a hybrid algorithm that combines Fuzzy Logic Controller (FLC and Genetic Algorithms (GAs and its application on a traffic signal system. FLCs have been widely used in many applications in diverse areas, such as control system, pattern recognition, signal processing, and forecasting. They are, essentially, rule-based systems, in which the definition of these rules and fuzzy membership functions is generally based on verbally formulated rules that overlap through the parameter space. They have a great influence over the performance of the system. On the other hand, the Genetic Algorithm is a metaheuristic that provides a robust search in complex spaces. In this work, it has been used to adapt the decision rules of FLCs that define an intelligent traffic signal system, obtaining a higher performance than a classical FLC-based control. The simulation results yielded by the hybrid algorithm show an improvement of up to 34% in the performance with respect to a standard traffic signal controller, Conventional Traffic Signal Controller (CTC, and up to 31% in the comparison with a traditional logic controller, FLC.

  9. Improved Protein Arrays for Quantitative Systems Analysis of the Dynamics of Signaling Pathway Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Chin-Rang [National Inst. of Health (NIH), Bethesda, MD (United States). National Heart, Lung and Blood Inst.

    2013-12-11

    Astronauts and workers in nuclear plants who repeatedly exposed to low doses of ionizing radiation (IR, <10 cGy) are likely to incur specific changes in signal transduction and gene expression in various tissues of their body. Remarkable advances in high throughput genomics and proteomics technologies enable researchers to broaden their focus from examining single gene/protein kinetics to better understanding global gene/protein expression profiling and biological pathway analyses, namely Systems Biology. An ultimate goal of systems biology is to develop dynamic mathematical models of interacting biological systems capable of simulating living systems in a computer. This Glue Grant is to complement Dr. Boothman’s existing DOE grant (No. DE-FG02-06ER64186) entitled “The IGF1/IGF-1R-MAPK-Secretory Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-Inducible Bystander Effect” to develop sensitive and quantitative proteomic technology that suitable for low dose radiobiology researches. An improved version of quantitative protein array platform utilizing linear Quantum dot signaling for systematically measuring protein levels and phosphorylation states for systems biology modeling is presented. The signals are amplified by a confocal laser Quantum dot scanner resulting in ~1000-fold more sensitivity than traditional Western blots and show the good linearity that is impossible for the signals of HRP-amplification. Therefore this improved protein array technology is suitable to detect weak responses of low dose radiation. Software is developed to facilitate the quantitative readout of signaling network activities. Kinetics of EGFRvIII mutant signaling was analyzed to quantify cross-talks between EGFR and other signaling pathways.

  10. Increasing reliability of defect characterization on sg tubings using a combination of signal processing and expert system

    International Nuclear Information System (INIS)

    Benoist, B.; David, B.; Pigeon, M.

    1989-01-01

    An expert system is developed for automatic analysis of eddy current signals provided by the multifrequency control of steam generators tubing. This article describes on one hand the aim and the results of the elimination of pilgrim noise, on the other hand the expert system which uses signal analysis and signal processing in unison

  11. A novel ecdysone receptor mediates steroid-regulated developmental events during the mid-third instar of Drosophila.

    Directory of Open Access Journals (Sweden)

    Benjamin F B Costantino

    2008-06-01

    Full Text Available The larval salivary gland of Drosophila melanogaster synthesizes and secretes glue glycoproteins that cement developing animals to a solid surface during metamorphosis. The steroid hormone 20-hydroxyecdysone (20E is an essential signaling molecule that modulates most of the physiological functions of the larval gland. At the end of larval development, it is known that 20E--signaling through a nuclear receptor heterodimer consisting of EcR and USP--induces the early and late puffing cascade of the polytene chromosomes and causes the exocytosis of stored glue granules into the lumen of the gland. It has also been reported that an earlier pulse of hormone induces the temporally and spatially specific transcriptional activation of the glue genes; however, the receptor responsible for triggering this response has not been characterized. Here we show that the coordinated expression of the glue genes midway through the third instar is mediated by 20E acting to induce genes of the Broad Complex (BRC through a receptor that is not an EcR/USP heterodimer. This result is novel because it demonstrates for the first time that at least some 20E-mediated, mid-larval, developmental responses are controlled by an uncharacterized receptor that does not contain an RXR-like component.

  12. Underlay Spectrum Sharing Techniques with In-Band Full-Duplex Systems using Improper Gaussian Signaling

    KAUST Repository

    Gaafar, Mohamed

    2016-10-26

    Sharing the spectrum with in-band full-duplex (FD) primary users (PUs) is a challenging and interesting problem in the underlay cognitive radio (CR) systems. The self-interference introduced at the primary network may dramatically impede the secondary user (SU) opportunity to access the spectrum. To tackle this problem, we use the so-called improper Gaussian signaling. Particularly, we assume the downlink transmission of a SU that uses improper Gaussian signaling while the FD PU pair implements the regular proper Gaussian signaling. First, we derive a closed form expression and an upper bound for the SU and PUs outage probabilities, respectively. Second, we optimize the SU signal parameters to minimize its outage probability while maintaining the required PUs quality-of-service based on the average channel state information (CSI). Moreover, we provide the conditions to reap merits from employing improper Gaussian signaling at the SU. Third, we design the SU signal parameters based on perfect knowledge of its direct link instantaneous CSI and investigate all benefits that can be achieved at both the SU and PUs. Finally, we provide some numerical results that demonstrate the advantages of using improper Gaussian signaling to access the spectrum of the FD PUs.

  13. Development of a central PC-based system for reactor signal monitoring and analysis

    International Nuclear Information System (INIS)

    Karim, A.; Ansari, S.A.; Baig, A.R.

    1996-05-01

    A personal computer based system was developed for on-line monitoring, signal processing and display of important parameters of the Pakistan Reactor-1. The system was designed for assistance to both reactor operator and users. It performs three main functions. The first is the centralized radiation monitoring in and around the reactor building. The computer acquires signals from radiation monitoring channels and continuously displays them on distributed monitors. Trend monitoring and alarm generation is also done. In case of any abnormal condition the radiation level data is automatically stored in computer memory for detailed off-line analysis. In the second part the computer does the performance testing of nuclear instrumentation channels by signal statistical analysis and generates alarm in case the channel standard deviation error exceeds the permissible error. Mean values of important nuclear signals are also displayed on distributed monitors as a part of reactor safety parameters display system. The third function is on-line computation of reactor physics parameters of the core which are important from operational and safety point-of-view. The signals from radiation protection system and nuclear instrumentation channels in the reactor were interfaced with the computer for this purpose. The development work was done under an IAEA research contract as a part of coordinated research programme. (author) 12 figs

  14. Development of a central PC-based system for reactor signal monitoring and analysis

    International Nuclear Information System (INIS)

    Karim, A.; Ansari, S.A.; Rauf Baig, A.

    1998-01-01

    A personal computer based system was developed for on-line monitoring, signal processing and display of important reactor parameters of the Pakistan Research Reactor-1. The system was designed for assistance to both reactor operator and users. It performs three main functions. The first is the centralized radiation monitoring in and around the reactor building. The computer acquires signals from radiation monitoring channels and continuously displays them on distributed monitors. Trend monitoring and alarm generation is also done. In case of any abnormal condition the radiation level data is automatically stored in computer memory for detailed off-line analysis. In the second part the computer does the performance testing of nuclear instrumentation channels by signal statistical analysis, and generates alarm in case the channel standard deviation error exceeds the permissible error. Mean values of important nuclear signals are also displayed on distributed monitors as a part of reactor safety parameters display system. The third function is on-line computation of reactor physics parameters of the core which are important from operational and safety points-of-view. The signals from radiation protection system and nuclear instrumentation channels in the reactor were interfaced with the computer for this purpose. The development work was done under an IAEA research contract as a part of coordinated research programme. (author)

  15. A web-based quantitative signal detection system on adverse drug reaction in China.

    Science.gov (United States)

    Li, Chanjuan; Xia, Jielai; Deng, Jianxiong; Chen, Wenge; Wang, Suzhen; Jiang, Jing; Chen, Guanquan

    2009-07-01

    To establish a web-based quantitative signal detection system for adverse drug reactions (ADRs) based on spontaneous reporting to the Guangdong province drug-monitoring database in China. Using Microsoft Visual Basic and Active Server Pages programming languages and SQL Server 2000, a web-based system with three software modules was programmed to perform data preparation and association detection, and to generate reports. Information component (IC), the internationally recognized measure of disproportionality for quantitative signal detection, was integrated into the system, and its capacity for signal detection was tested with ADR reports collected from 1 January 2002 to 30 June 2007 in Guangdong. A total of 2,496 associations including known signals were mined from the test database. Signals (e.g., cefradine-induced hematuria) were found early by using the IC analysis. In addition, 291 drug-ADR associations were alerted for the first time in the second quarter of 2007. The system can be used for the detection of significant associations from the Guangdong drug-monitoring database and could be an extremely useful adjunct to the expert assessment of very large numbers of spontaneously reported ADRs for the first time in China.

  16. System and method of modulating electrical signals using photoconductive wide bandgap semiconductors as variable resistors

    Science.gov (United States)

    Harris, John Richardson; Caporaso, George J; Sampayan, Stephen E

    2013-10-22

    A system and method for producing modulated electrical signals. The system uses a variable resistor having a photoconductive wide bandgap semiconductor material construction whose conduction response to changes in amplitude of incident radiation is substantially linear throughout a non-saturation region to enable operation in non-avalanche mode. The system also includes a modulated radiation source, such as a modulated laser, for producing amplitude-modulated radiation with which to direct upon the variable resistor and modulate its conduction response. A voltage source and an output port, are both operably connected to the variable resistor so that an electrical signal may be produced at the output port by way of the variable resistor, either generated by activation of the variable resistor or propagating through the variable resistor. In this manner, the electrical signal is modulated by the variable resistor so as to have a waveform substantially similar to the amplitude-modulated radiation.

  17. FUSING SPEECH SIGNAL AND PALMPRINT FEATURES FOR AN SECURED AUTHENTICATION SYSTEM

    Directory of Open Access Journals (Sweden)

    P.K. Mahesh

    2011-11-01

    Full Text Available In the application of Biometric authentication, personal identification is regarded as an effective method for automatic recognition, with a high confidence, a person’s identity. Using multimodal biometric systems we typically get better performance compare to single biometric modality. This paper proposes the multimodal biometrics system for identity verification using two traits, i.e., speech signal and palmprint. Integrating the palmprint and speech information increases robustness of person authentication. The proposed system is designed for applications where the training data contains a speech signal and palmprint. It is well known that the performance of person authentication using only speech signal or palmprint is deteriorated by feature changes with time. The final decision is made by fusion at matching score level architecture in which feature vectors are created independently for query measures and are then compared to the enrolment templates, which are stored during database preparation.

  18. Down sampled signal processing for a B Factory bunch-by-bunch feedback system

    International Nuclear Information System (INIS)

    Hindi, H.; Hosseini, W.; Briggs, D.; Fox, J.; Hutton, A.

    1992-03-01

    A bunch-by-bunch feedback scheme is studied for damping coupled bunch synchrotron oscillations in the proposed PEP II B Factory. The quasi-linear feedback systems design incorporates a phase detector to provide a quantized measure of bunch phase, digital signal processing to compute an error correction signal and a kicker system to correct the energy of the bunches. A farm of digital processors, operating in parallel, is proposed to compute correction signals for the 1658 bunches of the B Factory. This paper studies the use of down sampled processing to reduce the computational complexity of the feedback system. We present simulation results showing the effect of down sampling on beam dynamics. Results show that down sampled processing can reduce the scale of the processing task by a factor of 10

  19. Discovery of a novel insect neuropeptide signaling system closely related to the insect adipokinetic hormone and corazonin hormonal systems

    DEFF Research Database (Denmark)

    Hansen, Karina Kiilerich; Stafflinger, Elisabeth; Schneider, Martina

    2010-01-01

    receptors, this is a prominent example of receptor/ligand co-evolution, probably originating from receptor and ligand gene duplications followed by mutations and evolutionary selection, thereby yielding three independent hormonal systems. The ACP signaling system occurs in the mosquitoes A. gambiae, Aedes...

  20. Pavement cells: a model system for non-transcriptional auxin signalling and crosstalks.

    Science.gov (United States)

    Chen, Jisheng; Wang, Fei; Zheng, Shiqin; Xu, Tongda; Yang, Zhenbiao

    2015-08-01

    Auxin (indole acetic acid) is a multifunctional phytohormone controlling various developmental patterns, morphogenetic processes, and growth behaviours in plants. The transcription-based pathway activated by the nuclear TRANSPORT INHIBITOR RESISTANT 1/auxin-related F-box auxin receptors is well established, but the long-sought molecular mechanisms of non-transcriptional auxin signalling remained enigmatic until very recently. Along with the establishment of the Arabidopsis leaf epidermal pavement cell (PC) as an exciting and amenable model system in the past decade, we began to gain insight into non-transcriptional auxin signalling. The puzzle-piece shape of PCs forms from intercalated or interdigitated cell growth, requiring local intra- and inter-cellular coordination of lobe and indent formation. Precise coordination of this interdigitated pattern requires auxin and an extracellular auxin sensing system that activates plasma membrane-associated Rho GTPases from plants and subsequent downstream events regulating cytoskeletal reorganization and PIN polarization. Apart from auxin, mechanical stress and cytokinin have been shown to affect PC interdigitation, possibly by interacting with auxin signals. This review focuses upon signalling mechanisms for cell polarity formation in PCs, with an emphasis on non-transcriptional auxin signalling in polarized cell expansion and pattern formation and how different auxin pathways interplay with each other and with other signals. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  1. Redox modification of caveolar proteins in the cardiovascular system- role in cellular signalling and disease.

    Science.gov (United States)

    Bubb, Kristen J; Birgisdottir, Asa Birna; Tang, Owen; Hansen, Thomas; Figtree, Gemma A

    2017-08-01

    Rapid and coordinated release of a variety of reactive oxygen species (ROS) such as superoxide (O 2 .- ), hydrogen peroxide (H 2 O 2 ) and peroxynitrite, in specific microdomains, play a crucial role in cell signalling in the cardiovascular system. These reactions are mediated by reversible and functional modifications of a wide variety of key proteins. Dysregulation of this oxidative signalling occurs in almost all forms of cardiovascular disease (CVD), including at the very early phases. Despite the heavily publicized failure of "antioxidants" to improve CVD progression, pharmacotherapies such as those targeting the renin-angiotensin system, or statins, exert at least part of their large clinical benefit via modulating cellular redox signalling. Over 250 proteins, including receptors, ion channels and pumps, and signalling proteins are found in the caveolae. An increasing proportion of these are being recognized as redox regulated-proteins, that reside in the immediate vicinity of the two major cellular sources of ROS, nicotinamide adenine dinucleotide phosphate oxidase (Nox) and uncoupled endothelial nitric oxide synthase (eNOS). This review focuses on what is known about redox signalling within the caveolae, as well as endogenous protective mechanisms utilized by the cell, and new approaches to targeting dysregulated redox signalling in the caveolae as a therapeutic strategy in CVD. Copyright © 2017. Published by Elsevier Inc.

  2. Sharing the Licensed Spectrum of Full-Duplex Systems Using Improper Gaussian Signaling

    KAUST Repository

    Gaafar, Mohamed

    2015-12-01

    Sharing the spectrum with in-band full-duplex (FD) primary users (PU) is a challenging and interesting problem in the underlay cognitive radio (CR) systems. The self-interference introduced at the primary network may dramatically impede the secondary user (SU) opportunity to access the spectrum. In this work, we attempt to tackle this problem through the use of the so-called improper Gaussian signaling. Such a signaling technique has demonstrated its superiority in improving the overall performance in interference limited networks. Particularly, we assume a system with a SU pair working in half-duplex mode that uses improper Gaussian signaling while the FD PU pair implements the regular proper Gaussian signaling techniques. First, we derive a closed form expression for the SU outage probability and an upper bound for the PU outage probability. Then, we optimize the SU signal parameters to minimize its outage probability while maintaining the required PU quality-of-service based on the average channel state information. Finally, we provide some numerical results that validate the tightness of the PU outage probability bound and demonstrate the advantage of employing the improper Gaussian signaling to the SU in order to access the spectrum of the FD PU.

  3. Controlling a human-computer interface system with a novel classification method that uses electrooculography signals.

    Science.gov (United States)

    Wu, Shang-Lin; Liao, Lun-De; Lu, Shao-Wei; Jiang, Wei-Ling; Chen, Shi-An; Lin, Chin-Teng

    2013-08-01

    Electrooculography (EOG) signals can be used to control human-computer interface (HCI) systems, if properly classified. The ability to measure and process these signals may help HCI users to overcome many of the physical limitations and inconveniences in daily life. However, there are currently no effective multidirectional classification methods for monitoring eye movements. Here, we describe a classification method used in a wireless EOG-based HCI device for detecting eye movements in eight directions. This device includes wireless EOG signal acquisition components, wet electrodes and an EOG signal classification algorithm. The EOG classification algorithm is based on extracting features from the electrical signals corresponding to eight directions of eye movement (up, down, left, right, up-left, down-left, up-right, and down-right) and blinking. The recognition and processing of these eight different features were achieved in real-life conditions, demonstrating that this device can reliably measure the features of EOG signals. This system and its classification procedure provide an effective method for identifying eye movements. Additionally, it may be applied to study eye functions in real-life conditions in the near future.

  4. Grey signal processing and data reconstruction in the non-diffracting beam triangulation measurement system

    Science.gov (United States)

    Meng, Hao; Wang, Zhongyu; Fu, Jihua

    2008-12-01

    The non-diffracting beam triangulation measurement system possesses the advantages of longer measurement range, higher theoretical measurement accuracy and higher resolution over the traditional laser triangulation measurement system. Unfortunately the measurement accuracy of the system is greatly degraded due to the speckle noise, the CCD photoelectric noise and the background light noise in practical applications. Hence, some effective signal processing methods must be applied to improve the measurement accuracy. In this paper a novel effective method for removing the noises in the non-diffracting beam triangulation measurement system is proposed. In the method the grey system theory is used to process and reconstruct the measurement signal. Through implementing the grey dynamic filtering based on the dynamic GM(1,1), the noises can be effectively removed from the primary measurement data and the measurement accuracy of the system can be improved as a result.

  5. Dynamic Signal Strength Mapping and Analysis by Means of Mobile Geographic Information System

    Directory of Open Access Journals (Sweden)

    Kulawiak Marcin

    2017-12-01

    Full Text Available Bluetooth beacons are becoming increasingly popular for various applications such as marketing or indoor navigation. However, designing a proper beacon installation requires knowledge of the possible sources of interference in the target environment. While theoretically beacon signal strength should decay linearly with log distance, on-site measurements usually reveal that noise from objects such as Wi-Fi networks operating in the vicinity significantly alters the expected signal range. The paper presents a novel mobile Geographic Information System for measurement, mapping and local as well as online storage of Bluetooth beacon signal strength in semireal time. For the purpose of on-site geovisual analysis of the signal, the application integrates a dedicated interpolation algorithm optimized for low-power devices. The paper discusses the performance and quality of the mapping algorithms in several different test environments.

  6. Stochastic resonance in a time-delayed asymmetric bistable system with mixed periodic signal

    International Nuclear Information System (INIS)

    Yong-Feng, Guo; Wei, Xu; Liang, Wang

    2010-01-01

    This paper studies the phenomenon of stochastic resonance in an asymmetric bistable system with time-delayed feedback and mixed periodic signal by using the theory of signal-to-noise ratio in the adiabatic limit. A general approximate Fokker–Planck equation and the expression of the signal-to-noise ratio are derived through the small time delay approximation at both fundamental harmonics and mixed harmonics. The effects of the additive noise intensity Q, multiplicative noise intensity D, static asymmetry r and delay time τ on the signal-to-noise ratio are discussed. It is found that the higher mixed harmonics and the static asymmetry r can restrain stochastic resonance, and the delay time τ can enhance stochastic resonance. Moreover, the longer the delay time τ is, the larger the additive noise intensity Q and the multiplicative noise intensity D are, when the stochastic resonance appears. (general)

  7. Security region-based small signal stability analysis of power systems with FSIG based wind farm

    Science.gov (United States)

    Qin, Chao; Zeng, Yuan; Yang, Yang; Cui, Xiaodan; Xu, Xialing; Li, Yong

    2018-02-01

    Based on the Security Region approach, the impact of fixed-speed induction generator based wind farm on the small signal stability of power systems is analyzed. Firstly, the key factors of wind farm on the small signal stability of power systems are analyzed and the parameter space for small signal stability region is formed. Secondly, the small signal stability region of power systems with wind power is established. Thirdly, the corresponding relation between the boundary of SSSR and the dominant oscillation mode is further studied. Results show that the integration of fixed-speed induction generator based wind farm will cause the low frequency oscillation stability of the power system deteriorate. When the output of wind power is high, the oscillation stability of the power system is mainly concerned with the inter-area oscillation mode caused by the integration of the wind farm. Both the active power output and the capacity of reactive power compensation of the wind farm have a significant influence on the SSSR. To improve the oscillation stability of power systems with wind power, it is suggested to reasonably set the reactive power compensation capacity for the wind farm through SSSR.

  8. Systems Medicine in Oncology: Signaling Network Modeling and New-Generation Decision-Support Systems.

    Science.gov (United States)

    Parodi, Silvio; Riccardi, Giuseppe; Castagnino, Nicoletta; Tortolina, Lorenzo; Maffei, Massimo; Zoppoli, Gabriele; Nencioni, Alessio; Ballestrero, Alberto; Patrone, Franco

    2016-01-01

    Two different perspectives are the main focus of this book chapter: (1) A perspective that looks to the future, with the goal of devising rational associations of targeted inhibitors against distinct altered signaling-network pathways. This goal implies a sufficiently in-depth molecular diagnosis of the personal cancer of a given patient. A sufficiently robust and extended dynamic modeling will suggest rational combinations of the abovementioned oncoprotein inhibitors. The work toward new selective drugs, in the field of medicinal chemistry, is very intensive. Rational associations of selective drug inhibitors will become progressively a more realistic goal within the next 3-5 years. Toward the possibility of an implementation in standard oncologic structures of technologically sufficiently advanced countries, new (legal) rules probably will have to be established through a consensus process, at the level of both diagnostic and therapeutic behaviors.(2) The cancer patient of today is not the patient of 5-10 years from now. How to support the choice of the most convenient (and already clinically allowed) treatment for an individual cancer patient, as of today? We will consider the present level of artificial intelligence (AI) sophistication and the continuous feeding, updating, and integration of cancer-related new data, in AI systems. We will also report briefly about one of the most important projects in this field: IBM Watson US Cancer Centers. Allowing for a temporal shift, in the long term the two perspectives should move in the same direction, with a necessary time lag between them.

  9. Digital signal processing for CdTe detectors using VXIbus data collection systems

    Energy Technology Data Exchange (ETDEWEB)

    Fukuda, Daiji; Takahashi, Hiroyuki; Kurahashi, Tomohiko; Iguchi, Tetsuo; Nakazawa, Masaharu

    1996-07-01

    Recently fast signal digitizing technique has been developed, and signal waveforms with very short time periods can be obtained. In this paper, we analyzed each measured pulse which was digitized by an apparatus of this kind, and tried to improve an energy resolution of a CdTe semiconductor detector. The result of the energy resolution for {sup 137}Cs 662 keV photopeak was 13 keV. Also, we developed a fast data collection system based on VXIbus standard, and the counting rate on this system was obtained about 50 counts per second. (author)

  10. Modulation, resolution and signal processing in radar, sonar and related systems

    CERN Document Server

    Benjamin, R; Costrell, L

    1966-01-01

    Electronics and Instrumentation, Volume 35: Modulation, Resolution and Signal Processing in Radar, Sonar and Related Systems presents the practical limitations and potentialities of advanced modulation systems. This book discusses the concepts and techniques in the radar context, but they are equally essential to sonar and to a wide range of signaling and data-processing applications, including seismology, radio astronomy, and band-spread communications.Organized into 15 chapters, this volume begins with an overview of the principal developments sought in pulse radar. This text then provides a

  11. A summary of impacts of wind power integration on power system small-signal stability

    Science.gov (United States)

    Yan, Lei; Wang, Kewen

    2017-05-01

    Wind power has been increasingly integrated into power systems over the last few decades because of the global energy crisis and the pressure on environmental protection, and the stability of the system connected with wind power is becoming more prominent. This paper summaries the research status, achievements as well as deficiencies of the research on the impact of wind power integration on power system small-signal stability. In the end, the further research needed are discussed.

  12. Automatic calibration and signal switching system for the particle beam fusion research data acquisition facility

    Energy Technology Data Exchange (ETDEWEB)

    Boyer, W.B.

    1979-09-01

    This report describes both the hardware and software components of an automatic calibration and signal system (Autocal) for the data acquisition system for the Sandia particle beam fusion research accelerators Hydra, Proto I, and Proto II. The Autocal hardware consists of off-the-shelf commercial equipment. The various hardware components, special modifications and overall system configuration are described. Special software has been developed to support the Autocal hardware. Software operation and maintenance are described.

  13. Designing a Signal Conditioning System with Software Calibration for Resistor-feedback Patch Clamp Amplifier.

    Science.gov (United States)

    Hu, Gang; Zhu, Quanhui; Qu, Anlian

    2005-01-01

    In this paper, a programmable signal conditioning system based on software calibration for resistor-feedback patch clamp amplifier (PCA) has been described, this system is mainly composed of frequency correction, programmable gain and filter whose parameters are configured by software automatically to minimize the errors, A lab-designed data acquisition system (DAQ) is used to implement data collections and communications with PC. The laboratory test results show good agreement with design specifications.

  14. Automatic calibration and signal switching system for the particle beam fusion research data acquisition facility

    International Nuclear Information System (INIS)

    Boyer, W.B.

    1979-09-01

    This report describes both the hardware and software components of an automatic calibration and signal system (Autocal) for the data acquisition system for the Sandia particle beam fusion research accelerators Hydra, Proto I, and Proto II. The Autocal hardware consists of off-the-shelf commercial equipment. The various hardware components, special modifications and overall system configuration are described. Special software has been developed to support the Autocal hardware. Software operation and maintenance are described

  15. SC-CNNs for chaotic signal applications in secure communication systems.

    Science.gov (United States)

    Caponetto, Riccardo; Fortuna, Luigi; Occhipinti, Luigi; Xibilia, Maria Gabriella

    2003-12-01

    In this paper a CNNs based circuit for the generation of hyperchaotic signals is proposed. The circuit has been developed for applications in secure communication systems. An Saito oscillator has been designed by using a suitable configuration of a four-cells State-Controlled CNNs. A cryptography system based on the Saito oscillator has been implemented by using inverse system synchronization. The proposed circuit implementation and experimental results are given.

  16. Design of EEG Signal Acquisition System Using Arduino MEGA1280 and EEGAnalyzer

    Directory of Open Access Journals (Sweden)

    Saptono Debyo

    2016-01-01

    Full Text Available This study integrates the hardware circuit design and software development to achieve a 16 channels Electroencephalogram (EEG system for Brain Computer Interface (BCI applications. Signals obtained should be strong enough amplitude that is usually expressed in units of millivolts and reasonably clean of noise that appears when the data acquisition process. The process of data acquisition consists of two stages are the acquisition of the original EEG signal can be done by the active electrode with an instrumentation amplifier or a preamplifier and processing the signal to get better signals with improved signal quality by removing noise using filters with IC OPAMP. The design of a preamplifier with high common-mode rejection ratio and high signal-to-noise ratio is very important. Moreover, the friction between the electrode pads and the skin as well as the design of dual power supply. Designs used single-power AC-coupled circuit, which effectively reduces the DC bias and improves the error caused by the effects of part errors. At the same time, the digital way is applied to design the adjustable amplification and filter function, which can design for different EEG frequency bands. The next step, those EEG signals received by the microcontroller through a port Analog to Digital Converter (ADC that integrated and converted into digital signals and stored in the RAM of microcontroller which simultaneously at 16 ports in accordance with the minimal number of points of data collection on the human scalp. Implementation results have shown the series of acquisitions to work properly so that it can be displayed EEG signals via software EEGAnalyzer.

  17. Towards rationally redesigning bacterial signaling systems using information encoded in abundant sequence data

    Science.gov (United States)

    Cheng, Ryan; Morcos, Faruck; Levine, Herbert; Onuchic, Jose

    2014-03-01

    An important challenge in biology is to distinguish the subset of residues that allow bacterial two-component signaling (TCS) proteins to preferentially interact with their correct TCS partner such that they can bind and transfer signal. Detailed knowledge of this information would allow one to search sequence-space for mutations that can systematically tune the signal transmission between TCS partners as well as re-encode a TCS protein to preferentially transfer signals to a non-partner. Motivated by the notion that this detailed information is found in sequence data, we explore the mutual sequence co-evolution between signaling partners to infer how mutations can positively or negatively alter their interaction. Using Direct Coupling Analysis (DCA) for determining evolutionarily conserved interprotein interactions, we apply a DCA-based metric to quantify mutational changes in the interaction between TCS proteins and demonstrate that it accurately correlates with experimental mutagenesis studies probing the mutational change in the in vitro phosphotransfer. Our methodology serves as a potential framework for the rational design of TCS systems as well as a framework for the system-level study of protein-protein interactions in sequence-rich systems. This research has been supported by the NSF INSPIRE award MCB-1241332 and by the CTBP sponsored by the NSF (Grant PHY-1308264).

  18. The effectiveness of the jammer signal characteristics on conical-scan systems

    Science.gov (United States)

    Şahingil, Mehmet C.; Aslan, Murat Ş.

    2015-05-01

    Being passive systems and due to their proliferation to many regions in the world, the infrared (IR) guided missiles constitute probably the most dangerous threats for the aircraft platforms. Early generation surface-to-air and air-to-air IRguided missiles use reticle-based seekers. One of the IR countermeasure (IRCM) techniques for protecting aircraft platforms against these type of threats is to use a modulated jamming signal. Optimizing the parameters of the modulation is the most important issue for an effective protection. If the required characteristic is not satisfied, jamming may not be successful for protecting the aircraft. There are several parameters to define the jammer signal (modulation) characteristic. Optimizing them requires a good understanding of threat seekers' operating principles. In the present paper, we consider protection of a helicopter platform against conical-scan reticle based seeker systems and investigate the effect of the jammer signal modulation parameters on jamming performance via extensive batch simulations. The simulations are performed in a MATLAB-coded simulator which models reticle-based conical-scan seeker, aircraft radiation, aircraft motion and jammer system on the aircraft. The results show that if the properties of the jammer signal are similar to those of the reticle-modulated signal in the missile, the jamming can be successful. Otherwise, applied jamming may not deceive the threat seeker.

  19. Optical signal processing techniques and applications of optical phase modulation in high-speed communication systems

    Science.gov (United States)

    Deng, Ning

    In recent years, optical phase modulation has attracted much research attention in the field of fiber optic communications. Compared with the traditional optical intensity-modulated signal, one of the main merits of the optical phase-modulated signal is the better transmission performance. For optical phase modulation, in spite of the comprehensive study of its transmission performance, only a little research has been carried out in terms of its functions, applications and signal processing for future optical networks. These issues are systematically investigated in this thesis. The research findings suggest that optical phase modulation and its signal processing can greatly facilitate flexible network functions and high bandwidth which can be enjoyed by end users. In the thesis, the most important physical-layer technology, signal processing and multiplexing, are investigated with optical phase-modulated signals. Novel and advantageous signal processing and multiplexing approaches are proposed and studied. Experimental investigations are also reported and discussed in the thesis. Optical time-division multiplexing and demultiplexing. With the ever-increasing demand on communication bandwidth, optical time division multiplexing (OTDM) is an effective approach to upgrade the capacity of each wavelength channel in current optical systems. OTDM multiplexing can be simply realized, however, the demultiplexing requires relatively complicated signal processing and stringent timing control, and thus hinders its practicability. To tackle this problem, in this thesis a new OTDM scheme with hybrid DPSK and OOK signals is proposed. Experimental investigation shows this scheme can greatly enhance the demultiplexing timing misalignment and improve the demultiplexing performance, and thus make OTDM more practical and cost effective. All-optical signal processing. In current and future optical communication systems and networks, the data rate per wavelength has been approaching

  20. Cry-wolf signals emerging from coevolutionary feedbacks in a tritrophic system

    Science.gov (United States)

    Yamauchi, Atsushi; van Baalen, Minus; Kobayashi, Yutaka; Takabayashi, Junji; Shiojiri, Kaori; Sabelis, Maurice W.

    2015-01-01

    For a communication system to be stable, senders should convey honest information. Providing dishonest information, however, can be advantageous to senders, which imposes a constraint on the evolution of communication systems. Beyond single populations and bitrophic systems, one may ask whether stable communication systems can evolve in multitrophic systems. Consider cross-species signalling where herbivore-induced plant volatiles (HIPVs) attract predators to reduce the damage from arthropod herbivores. Such plant signals may be honest and help predators to identify profitable prey/plant types via HIPV composition and to assess prey density via the amount of HIPVs. There could be selection for dishonest signals that attract predators for protection from possible future herbivory. Recently, we described a case in which plants release a fixed, high amount of HIPVs independent of herbivore load, adopting what we labelled a ‘cry-wolf’ strategy. To understand when such signals evolve, we model coevolutionary interactions between plants, herbivores and predators, and show that both ‘honest’ and ‘cry-wolf’ types can emerge, depending on the assumed plant–herbivore encounter rates and herbivore population density. It is suggested that the ‘cry-wolf’ strategy may have evolved to reduce the risk of heavy damage in the future. Our model suggests that eco-evolutionary feedback loops involving a third species may have important consequences for the stability of this outcome. PMID:26538597

  1. 1-D Wavelet Signal Analysis of the Actuators Nonlinearities Impact on the Healthy Control Systems Performance

    Directory of Open Access Journals (Sweden)

    Nicolae Tudoroiu

    2017-09-01

    Full Text Available The objective of this paper is to investigate the use of the 1-D wavelet analysis to extract several patterns from signals data sets collected from healthy and faulty input-output signals of control systems as a preliminary step in real-time implementation of fault detection diagnosis and isolation strategies. The 1-D wavelet analysis proved that is an useful tool for signals processing, design and analysis based on wavelet transforms found in a wide range of control systems industrial applications. Based on the fact that in the real life there is a great similitude between the phenomena, we are motivated to extend the applicability of these techniques to solve similar applications from control systems field, such is done in our research work. Their efficiency will be demonstrated on a case study mainly chosen to evaluate the impact of the uncertainties and the nonlinearities of the sensors and actuators on the overall performance of the control systems. The proposed techniques are able to extract in frequency domain some pattern features (signatures of interest directly from the signals data set collected by data acquisition equipment from the control system.

  2. Linearity improvement on wide-range log signal of neutron measurement system for HANARO

    International Nuclear Information System (INIS)

    Kim, Young-Ki; Tuetken, Jeffrey S.

    1998-01-01

    This paper discusses engineering activities for improving the linearity characteristics of the Log Power signal from the neutron measurement system for HANARO. This neutron measurement system uses a fission chamber based detector which covers 10.3 decade-wide range from 10 -8 % full power(FP) up to 200%FP, The Log Power signal is designed to control the reactor at low power levels where most of the reactor physics tests are carried out. Therefore, the linearity characteristics of the Log Power signal is the major factor for accurate reactor power control. During the commissioning of the neutron measurement system, it was found that the linearity characteristics of the Log Power signal, especially near 10 -2 %FP, were not accurate enough for controlling the reactor during physics testing. Analysis of the system linearity data directly measured with reactor operating determined that the system was not operating per the design characteristics established from previous installations. The linearity data, which were taken as the reactor was increased in power, were sent to manufacturer's engineering group and a follow-up measures based on the analysis were then fed back to the field. Through step by step trouble-shooting activities, which included minor circuit modifications and alignment procedure changes, the linearity characteristics have been successfully improved and now exceed minimum performance requirements. This paper discusses the trouble-shooting techniques applied, the changes in the linearity characteristics, special circumstances in the HANARO application and the final resolution. (author)

  3. Digital nonlinearity compensation in high-capacity optical communication systems considering signal spectral broadening effect.

    Science.gov (United States)

    Xu, Tianhua; Karanov, Boris; Shevchenko, Nikita A; Lavery, Domaniç; Liga, Gabriele; Killey, Robert I; Bayvel, Polina

    2017-10-11

    Nyquist-spaced transmission and digital signal processing have proved effective in maximising the spectral efficiency and reach of optical communication systems. In these systems, Kerr nonlinearity determines the performance limits, and leads to spectral broadening of the signals propagating in the fibre. Although digital nonlinearity compensation was validated to be promising for mitigating Kerr nonlinearities, the impact of spectral broadening on nonlinearity compensation has never been quantified. In this paper, the performance of multi-channel digital back-propagation (MC-DBP) for compensating fibre nonlinearities in Nyquist-spaced optical communication systems is investigated, when the effect of signal spectral broadening is considered. It is found that accounting for the spectral broadening effect is crucial for achieving the best performance of DBP in both single-channel and multi-channel communication systems, independent of modulation formats used. For multi-channel systems, the degradation of DBP performance due to neglecting the spectral broadening effect in the compensation is more significant for outer channels. Our work also quantified the minimum bandwidths of optical receivers and signal processing devices to ensure the optimal compensation of deterministic nonlinear distortions.

  4. Influence of Signal and Noise on Statistical Fluctuation of Single-Mode Laser System

    International Nuclear Information System (INIS)

    Xu Dahai; Cheng Qinghua; Cao Li; Wu Dajin

    2006-01-01

    On the basis of calculating the steady-state mean normalized intensity fluctuation of a signal-mode laser system driven by both colored pump noise with signal modulation and the quantum noise with cross-correlation between its real and imaginary parts, we analyze the influence of modulation signal, noise, and its correlation form on the statistical fluctuation of the laser system. We have found that when the amplitude of modulation signal weakens and its frequency quickens, the statistical fluctuation will reduce rapidly. The statistical fluctuation of the laser system can be restrained by reducing the intensity of pump noise and quantum noise. Moreover, with prolonging of colored cross-correlation time, the statistical fluctuation of laser system experiences a repeated changing process, that is, from decreasing to augmenting, then to decreasing, and finally to augmenting again. With the decreasing of the value of cross-correlation coefficient, the statistical fluctuation will decrease too. When the cross-correlation form between the real part and imaginary part of quantum noise is zero correlation, the statistical fluctuation of laser system has a minimum. Compared with the influence of intensity of pump noise, the influence of intensity of quantum noise on the statistical fluctuation is smaller.

  5. Comparison Study of Power System Small Signal Stability Improvement Using SSSC and STATCOM

    DEFF Research Database (Denmark)

    Hu, Weihao; Su, Chi; Fang, Jiakun

    2013-01-01

    the connected power system, both SSSC and STATCOM are able to participate in the power system inter-area oscillation damping by changing the compensated reactance or the provided reactive power. This paper analyses the influence of SSSC and STATCOM on power system small signal stability. The damping controller...... schemes for SSSC and STATCOM are presented and discussed. The IEEE 39-bus New England system model as the test system is built in DIgSIELNT PowerFactory, in which the damping control strategies for both SSSC and STATCOM are validated by time domain simulations and modal analysis. Furthermore, comparison......A static synchronous series compensator (SSSC) has the ability to emulate a reactance in series with the connected transmission line. A static synchronous compensator (STATCOM) is able to provide the reactive power to an electricity network. When fed with some supplementary signals from...

  6. A digital signal processor based rf control system for the TRIUMF ISAC RFQ prototype

    International Nuclear Information System (INIS)

    Fong, K.; Fang, S.; Laverty, M.

    1996-01-01

    A stand alone digital signal processor is used to control the RFQ prototype in the TRIUMF ISAC development program. The advantage of a digital control system over the traditional analogue system is that it offers the higher degree of flexibility necessary for a development system. For this application the system is designed to have the outward appearance of an analogue system, and uses dials, knobs, and switches as the operator interface. The digital signal processor is used as a feedback controller during CW rf operation, with the feedback gain parameters continually adjustable. It is also able to perform the same regulation during pulsed operation, with additional feedforward compensation for initial pulse on duration. Using a low cost analogue-to-digital converter with a sample rate of 100 kHz, a regulation bandwidth of 10 kHz is achieved. (author)

  7. Control of stochastic resonance in bistable systems by using periodic signals

    International Nuclear Information System (INIS)

    Min, Lin; Li-Min, Fang; Yong-Jun, Zheng

    2009-01-01

    According to the characteristic structure of double wells in bistable systems, this paper analyses stochastic fluctuations in the single potential well and probability transitions between the two potential wells and proposes a method of controlling stochastic resonance by using a periodic signal. Results of theoretical analysis and numerical simulation show that the phenomenon of stochastic resonance happens when the time scales of the periodic signal and the noise-induced probability transitions between the two potential wells achieve stochastic synchronization. By adding a bistable system with a controllable periodic signal, fluctuations in the single potential well can be effectively controlled, thus affecting the probability transitions between the two potential wells. In this way, an effective control can be achieved which allows one to either enhance or realize stochastic resonance

  8. Wave failure at strong coupling in intracellular C a2 + signaling system with clustered channels

    Science.gov (United States)

    Li, Xiang; Wu, Yuning; Gao, Xuejuan; Cai, Meichun; Shuai, Jianwei

    2018-01-01

    As an important intracellular signal, C a2 + ions control diverse cellular functions. In this paper, we discuss the C a2 + signaling with a two-dimensional model in which the inositol 1,4,5-trisphosphate (I P3 ) receptor channels are distributed in clusters on the endoplasmic reticulum membrane. The wave failure at large C a2 + diffusion coupling is discussed in detail in the model. We show that with varying model parameters the wave failure is a robust behavior with either deterministic or stochastic channel dynamics. We suggest that the wave failure should be a general behavior in inhomogeneous diffusing systems with clustered excitable regions and may occur in biological C a2 + signaling systems.

  9. Pilot Signal Design and Direct Ranging Methods for Radio Localization Using OFDM Systems

    DEFF Research Database (Denmark)

    Jing, Lishuai

    Having accurate localization capability is becoming important for existing and future terrestrial wireless communication systems, in particular for orthogonal frequency-division multiplexing (OFDM) systems, such as WiMAX, wireless local area network, long-term evolution (LTE) and its extension LTE......-Advanced. To obtain accurate position estimates, not only advanced estimation algorithms are needed but also the transmitted signals should be scrutinized. In this dissertation, we investigate how to design OFDM pilot signals and propose and evaluate high accuracy ranging techniques with tractable computational....... For scenarios where the number of path components is unknown and these components are not necessary separable, we propose a direct ranging technique using the received frequency-domain OFDM pilot signals. Compared to conventional (two-step) ranging methods, which estimate intermediate parameters...

  10. Active Bio-sensor System, Compatible with Arm Muscle Movement or Blinking Signals in BCI Application

    Directory of Open Access Journals (Sweden)

    Saeid Mehrkanoon

    2008-05-01

    Full Text Available This paper addresses a bionic active sensor system for the BCI application. Proposed system involves analog and digital parts. Two types of accurate sensors are used to pickup the blinking and muscle movement signals. A precision micro-power instrumentation amplifier with the adjustable gain, a sixth order low pass active filter with cutoff frequency 0.1 Hz, and a sixth order band pas filter with the bandwidth of 2-6 Hz are constructed to provide the clean blinking and arm muscle movement signals. TMS320C25 DSP processor is used for independent and unique command signals which are prepared for BCI application by a power amplifier and driver.

  11. Development and testing of an integrated signal validation system for nuclear power plants

    International Nuclear Information System (INIS)

    Upadhyaya, B.R.; Kerlin, T.W.; Gaudio, P.J. Jr.

    1989-09-01

    Since the incident at Three Mile Island unit 2, computerized plant status display, implementation of human factors in control room design, and plant monitoring based on expert system technology have seen a tremendous growth. One such proposed operator assist device is a plant signal validation system. This system is used to check the consistency of redundant measurements (sensors) of selected process variables, estimate their expect values from plant-wide data, and detect, isolate and characterize the type of anomaly in the instrument channel outputs. In large process control systems signals from several hundred instrument channels are routed via data highways to control systems, protection (safety) systems and plant monitoring systems. The need of automated signal validation is necessary because of the large amount of information available, and as a result the operator's inability to validate information from many diverse sources. This is also useful for improved plant control (minimize challenges on control systems), minimizing plant downtime, and for predictive maintenance advising. 107 refs., 56 figs., 6 tabs

  12. Design of a Continuous Blood Pressure Measurement System Based on Pulse Wave and ECG Signals.

    Science.gov (United States)

    Li, Jian-Qiang; Li, Rui; Chen, Zhuang-Zhuang; Deng, Gen-Qiang; Wang, Huihui; Mavromoustakis, Constandinos X; Song, Houbing; Ming, Zhong

    2018-01-01

    With increasingly fierce competition for jobs, the pressures on people have risen in recent years, leading to lifestyle and diet disorders that result in significantly higher risks of cardiovascular disease. Hypertension is one of the common chronic cardiovascular diseases; however, mainstream blood pressure measurement devices are relatively heavy. When multiple measurements are required, the user experience and the measurement results may be unsatisfactory. In this paper, we describe the design of a signal collection module that collects pulse waves and electrocardiograph (ECG) signals. The collected signals are input into a signal processing module to filter the noise and amplify the useful physiological signals. Then, we use a wavelet transform to eliminate baseline drift noise and detect the feature points of the pulse waves and ECG signals. We propose the concept of detecting the wave shape associated with an instance, an approach that minimizes the impact of atypical pulse waves on blood pressure measurements. Finally, we propose an improved method for measuring blood pressure based on pulse wave velocity that improves the accuracy of blood pressure measurements by 58%. Moreover, the results meet the american medical instrument promotion association standards, which demonstrate the feasibility of our measurement system.

  13. A Phytase-Based Reporter System for Identification of Functional Secretion Signals in Bifidobacteria.

    Directory of Open Access Journals (Sweden)

    Annika Osswald

    Full Text Available Health-promoting effects have been attributed to a number of Bifidobacterium sp. strains. These effects as well as the ability to colonise the host depend on secreted proteins. Moreover, rational design of protein secretion systems bears the potential for the generation of novel probiotic bifidobacteria with improved health-promoting or therapeutic properties. To date, there is only very limited data on secretion signals of bifidobacteria available. Using in silico analysis, we demonstrate that all bifidobacteria encode the major components of Sec-dependent secretion machineries but only B. longum strains harbour Tat protein translocation systems. A reporter plasmid for secretion signals in bifidobacteria was established by fusing the coding sequence of the signal peptide of a sialidase of Bifidobacterium bifidum S17 to the phytase gene appA of E. coli. The recombinant strain showed increased phytase activity in spent culture supernatants and reduced phytase levels in crude extracts compared to the control indicating efficient phytase secretion. The reporter plasmid was used to screen seven predicted signal peptides in B. bifidum S17 and B. longum E18. The tested signal peptides differed substantially in their efficacy to mediate protein secretion in different host strains. An efficient signal peptide was used for expression and secretion of a therapeutically relevant protein in B. bifidum S17. Expression of a secreted cytosine deaminase led to a 100-fold reduced sensitivity of B. bifidum S17 to 5-fluorocytosine compared to the non-secreted cytosine deaminase suggesting efficient conversion of 5-fluorocytosine to the cytotoxic cancer drug 5-fluorouracil by cytosine deaminase occurred outside the bacterial cell. Selection of appropriate signal peptides for defined protein secretion might improve therapeutic efficacy as well as probiotic properties of bifidobacteria.

  14. A Phytase-Based Reporter System for Identification of Functional Secretion Signals in Bifidobacteria

    Science.gov (United States)

    Osswald, Annika; Westermann, Christina; Sun, Zhongke; Riedel, Christian U.

    2015-01-01

    Health-promoting effects have been attributed to a number of Bifidobacterium sp. strains. These effects as well as the ability to colonise the host depend on secreted proteins. Moreover, rational design of protein secretion systems bears the potential for the generation of novel probiotic bifidobacteria with improved health-promoting or therapeutic properties. To date, there is only very limited data on secretion signals of bifidobacteria available. Using in silico analysis, we demonstrate that all bifidobacteria encode the major components of Sec-dependent secretion machineries but only B. longum strains harbour Tat protein translocation systems. A reporter plasmid for secretion signals in bifidobacteria was established by fusing the coding sequence of the signal peptide of a sialidase of Bifidobacterium bifidum S17 to the phytase gene appA of E. coli. The recombinant strain showed increased phytase activity in spent culture supernatants and reduced phytase levels in crude extracts compared to the control indicating efficient phytase secretion. The reporter plasmid was used to screen seven predicted signal peptides in B. bifidum S17 and B. longum E18. The tested signal peptides differed substantially in their efficacy to mediate protein secretion in different host strains. An efficient signal peptide was used for expression and secretion of a therapeutically relevant protein in B. bifidum S17. Expression of a secreted cytosine deaminase led to a 100-fold reduced sensitivity of B. bifidum S17 to 5-fluorocytosine compared to the non-secreted cytosine deaminase suggesting efficient conversion of 5-fluorocytosine to the cytotoxic cancer drug 5-fluorouracil by cytosine deaminase occurred outside the bacterial cell. Selection of appropriate signal peptides for defined protein secretion might improve therapeutic efficacy as well as probiotic properties of bifidobacteria. PMID:26086721

  15. Demodulation of acoustic telemetry binary phase shift keying signal based on high-order Duffing system

    International Nuclear Information System (INIS)

    Yan Bing-Nan; Liu Chong-Xin; Ni Jun-Kang; Zhao Liang

    2016-01-01

    In order to grasp the downhole situation immediately, logging while drilling (LWD) technology is adopted. One of the LWD technologies, called acoustic telemetry, can be successfully applied to modern drilling. It is critical for acoustic telemetry technology that the signal is successfully transmitted to the ground. In this paper, binary phase shift keying (BPSK) is used to modulate carrier waves for the transmission and a new BPSK demodulation scheme based on Duffing chaos is investigated. Firstly, a high-order system is given in order to enhance the signal detection capability and it is realized through building a virtual circuit using an electronic workbench (EWB). Secondly, a new BPSK demodulation scheme is proposed based on the intermittent chaos phenomena of the new Duffing system. Finally, a system variable crossing zero-point equidistance method is proposed to obtain the phase difference between the system and the BPSK signal. Then it is determined that the digital signal transmitted from the bottom of the well is ‘0’ or ‘1’. The simulation results show that the demodulation method is feasible. (paper)

  16. Reference-tracking feedforward control design for linear dynamical systems through signal decomposition

    NARCIS (Netherlands)

    Kasemsinsup, Y.; Romagnoli, R.; Heertjes, M.F.; Weiland, S.; Butler, H.

    2017-01-01

    In this work, we study a novel approach towards the reference-tracking feedforward control design for linear dynamical systems. By utilizing the superposition property and exploiting signal decomposition together with a quadratic optimization process, we obtain a feedforward design procedure for

  17. Push-Pull and Feedback Mechanisms Can Align Signaling System Outputs with Inputs.

    Science.gov (United States)

    Andrews, Steven S; Peria, William J; Yu, Richard C; Colman-Lerner, Alejandro; Brent, Roger

    2016-11-23

    Many cell signaling systems, including the yeast pheromone response system, exhibit "dose-response alignment" (DoRA), in which output of one or more downstream steps closely matches the fraction of occupied receptors. DoRA can improve the fidelity of transmitted dose information. Here, we searched systematically for biochemical network topologies that produced DoRA. Most networks, including many containing feedback and feedforward loops, could not produce DoRA. However, networks including "push-pull" mechanisms, in which the active form of a signaling species stimulates downstream activity and the nominally inactive form reduces downstream activity, enabled perfect DoRA. Networks containing feedbacks enabled DoRA, but only if they also compared feedback to input and adjusted output to match. Our results establish push-pull as a non-feedback mechanism to align output with variable input and maximize information transfer in signaling systems. They also suggest genetic approaches to determine whether particular signaling systems use feedback or push-pull control. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. A multilevel system of algorithms for detecting and isolating signals in a background of noise

    Science.gov (United States)

    Gurin, L. S.; Tsoy, K. A.

    1978-01-01

    Signal information is processed with the help of algorithms, and then on the basis of such processing, a part of the information is subjected to further processing with the help of more precise algorithms. Such a system of algorithms is studied, a comparative evaluation of a series of lower level algorithms is given, and the corresponding algorithms of higher level are characterized.

  19. Beacon Editor: Capturing Signal Transduction Pathways Using the Systems Biology Graphical Notation Activity Flow Language.

    Science.gov (United States)

    Elmarakeby, Haitham; Arefiyan, Mostafa; Myers, Elijah; Li, Song; Grene, Ruth; Heath, Lenwood S

    2017-12-01

    The Beacon Editor is a cross-platform desktop application for the creation and modification of signal transduction pathways using the Systems Biology Graphical Notation Activity Flow (SBGN-AF) language. Prompted by biologists' requests for enhancements, the Beacon Editor includes numerous powerful features for the benefit of creation and presentation.

  20. Toward quantifying metrics for rail-system resilience : Identification and analysis of performance weak resilience signals

    NARCIS (Netherlands)

    Regt, A. de; Siegel, A.W.; Schraagen, J.M.C.

    2016-01-01

    This paper aims to enhance tangibility of the resilience engineering concept by facilitating understanding and operationalization of weak resilience signals (WRSs) in the rail sector. Within complex socio-technical systems, accidents can be seen as unwanted outcomes emerging from uncontrolled

  1. High-speed ultra-wideband wireless signals over fiber systems: Photonic generation and DSP detection

    DEFF Research Database (Denmark)

    Yu, Xianbin; Gibbon, Timothy Braidwood; Tafur Monroy, Idelfonso

    2009-01-01

    We firstly review the efforts in the literature on UWB over-fiber systems. Secondly, we present experimental results on photonic generation of high-speed UWB signals by both direct modulation and external optical injecting an uncooled semiconductor laser. Furthermore, we introduce the use of digi...

  2. Expert system for eddy current signal analysis: non destructive testing of steam generator tubings

    International Nuclear Information System (INIS)

    Benoist, B.

    1991-01-01

    Automatic analysis, by computer, of defect signals in steam generator tubes, based on Eddy current multifrequency technique, is must often inefficient due to pilgrim noise. The first step is to use a method that allows us to eleminate the noise: the adaptative interpolation. Thanks to this method, which ensures reliable data on each channel, the analysis can be realised by taking into account the data corresponding to each basic or mixed channel. By correlating these diverse data, we can class the signals according to two types of defects: single defects (symmetrical), multiple defects (several in the same place). The second step is to use an expert system which allows a reliable diagnosis for whatever family the defect belongs to. According to this classification, analysis is continued and results in the characterization of the defect. The expert system has already been developed with the general purpose application expert system shell SUPER, which is briefly described. The knowledge base (SOCRATE) and the specific tools developed for this application are thoroughly described. The first results obtained with signals corresponding to real defects, that have been recorded in different places, are presented and discussed. The expert system is revealed efficient in all the studied cases, even with signals obtained in very noisy environments [fr

  3. Detection of driving fatigue by using noncontact EMG and ECG signals measurement system.

    Science.gov (United States)

    Fu, Rongrong; Wang, Hong

    2014-05-01

    Driver fatigue can be detected by constructing a discriminant mode using some features obtained from physiological signals. There exist two major challenges of this kind of methods. One is how to collect physiological signals from subjects while they are driving without any interruption. The other is to find features of physiological signals that are of corresponding change with the loss of attention caused by driver fatigue. Driving fatigue is detected based on the study of surface electromyography (EMG) and electrocardiograph (ECG) during the driving period. The noncontact data acquisition system was used to collect physiological signals from the biceps femoris of each subject to tackle the first challenge. Fast independent component analysis (FastICA) and digital filter were utilized to process the original signals. Based on the statistical analysis results given by Kolmogorov-Smirnov Z test, the peak factor of EMG (p fatigue of drivers. The discriminant criterion of fatigue was obtained from the training samples by using Mahalanobis distance, and then the average classification accuracy was given by 10-fold cross-validation. The results showed that the method proposed in this paper can give well performance in distinguishing the normal state and fatigue state. The noncontact, onboard vehicle drivers' fatigue detection system was developed to reduce fatigue-related risks.

  4. Characterization of a signal recording system for accurate velocity estimation using a VISAR

    Science.gov (United States)

    Rav, Amit; Joshi, K. D.; Singh, Kulbhushan; Kaushik, T. C.

    2018-02-01

    The linearity of a signal recording system (SRS) in time as well as in amplitude are important for the accurate estimation of the free surface velocity history of a moving target during shock loading and unloading when measured using optical interferometers such as a velocity interferometer system for any reflector (VISAR). Signal recording being the first step in a long sequence of signal processes, the incorporation of errors due to nonlinearity, and low signal-to-noise ratio (SNR) affects the overall accuracy and precision of the estimation of velocity history. In shock experiments the small duration (a few µs) of loading/unloading, the reflectivity of moving target surface, and the properties of optical components, control the amount of input of light to the SRS of a VISAR and this in turn affects the linearity and SNR of the overall measurement. These factors make it essential to develop in situ procedures for (i) minimizing the effect of signal induced noise and (ii) determine the linear region of operation for the SRS. Here we report on a procedure for the optimization of SRS parameters such as photodetector gain, optical power, aperture etc, so as to achieve a linear region of operation with a high SNR. The linear region of operation so determined has been utilized successfully to estimate the temporal history of the free surface velocity of the moving target in shock experiments.

  5. Signal Quality Improvement Algorithms for MEMS Gyroscope-Based Human Motion Analysis Systems: A Systematic Review

    Directory of Open Access Journals (Sweden)

    Jiaying Du

    2018-04-01

    Full Text Available Motion sensors such as MEMS gyroscopes and accelerometers are characterized by a small size, light weight, high sensitivity, and low cost. They are used in an increasing number of applications. However, they are easily influenced by environmental effects such as temperature change, shock, and vibration. Thus, signal processing is essential for minimizing errors and improving signal quality and system stability. The aim of this work is to investigate and present a systematic review of different signal error reduction algorithms that are used for MEMS gyroscope-based motion analysis systems for human motion analysis or have the potential to be used in this area. A systematic search was performed with the search engines/databases of the ACM Digital Library, IEEE Xplore, PubMed, and Scopus. Sixteen papers that focus on MEMS gyroscope-related signal processing and were published in journals or conference proceedings in the past 10 years were found and fully reviewed. Seventeen algorithms were categorized into four main groups: Kalman-filter-based algorithms, adaptive-based algorithms, simple filter algorithms, and compensation-based algorithms. The algorithms were analyzed and presented along with their characteristics such as advantages, disadvantages, and time limitations. A user guide to the most suitable signal processing algorithms within this area is presented.

  6. Signal Quality Improvement Algorithms for MEMS Gyroscope-Based Human Motion Analysis Systems: A Systematic Review.

    Science.gov (United States)

    Du, Jiaying; Gerdtman, Christer; Lindén, Maria

    2018-04-06

    Motion sensors such as MEMS gyroscopes and accelerometers are characterized by a small size, light weight, high sensitivity, and low cost. They are used in an increasing number of applications. However, they are easily influenced by environmental effects such as temperature change, shock, and vibration. Thus, signal processing is essential for minimizing errors and improving signal quality and system stability. The aim of this work is to investigate and present a systematic review of different signal error reduction algorithms that are used for MEMS gyroscope-based motion analysis systems for human motion analysis or have the potential to be used in this area. A systematic search was performed with the search engines/databases of the ACM Digital Library, IEEE Xplore, PubMed, and Scopus. Sixteen papers that focus on MEMS gyroscope-related signal processing and were published in journals or conference proceedings in the past 10 years were found and fully reviewed. Seventeen algorithms were categorized into four main groups: Kalman-filter-based algorithms, adaptive-based algorithms, simple filter algorithms, and compensation-based algorithms. The algorithms were analyzed and presented along with their characteristics such as advantages, disadvantages, and time limitations. A user guide to the most suitable signal processing algorithms within this area is presented.

  7. Pathogen-triggered ethylene signaling mediates systemic-induced susceptibility to herbivory in Arabidopsis.

    Science.gov (United States)

    Groen, Simon C; Whiteman, Noah K; Bahrami, Adam K; Wilczek, Amity M; Cui, Jianping; Russell, Jacob A; Cibrian-Jaramillo, Angelica; Butler, Ian A; Rana, Jignasha D; Huang, Guo-Hua; Bush, Jenifer; Ausubel, Frederick M; Pierce, Naomi E

    2013-11-01

    Multicellular eukaryotic organisms are attacked by numerous parasites from diverse phyla, often simultaneously or sequentially. An outstanding question in these interactions is how hosts integrate signals induced by the attack of different parasites. We used a model system comprised of the plant host Arabidopsis thaliana, the hemibiotrophic bacterial phytopathogen Pseudomonas syringae, and herbivorous larvae of the moth Trichoplusia ni (cabbage looper) to characterize mechanisms involved in systemic-induced susceptibility (SIS) to T. ni herbivory caused by prior infection by virulent P. syringae. We uncovered a complex multilayered induction mechanism for SIS to herbivory. In this mechanism, antiherbivore defenses that depend on signaling via (1) the jasmonic acid-isoleucine conjugate (JA-Ile) and (2) other octadecanoids are suppressed by microbe-associated molecular pattern-triggered salicylic acid (SA) signaling and infection-triggered ethylene signaling, respectively. SIS to herbivory is, in turn, counteracted by a combination of the bacterial JA-Ile mimic coronatine and type III virulence-associated effectors. Our results show that SIS to herbivory involves more than antagonistic signaling between SA and JA-Ile and provide insight into the unexpectedly complex mechanisms behind a seemingly simple trade-off in plant defense against multiple enemies.

  8. On the Use of an Algebraic Signature Analyzer for Mixed-Signal Systems Testing

    Directory of Open Access Journals (Sweden)

    Vadim Geurkov

    2014-01-01

    Full Text Available We propose an approach to design of an algebraic signature analyzer that can be used for mixed-signal systems testing. The analyzer does not contain carry propagating circuitry, which improves its performance as well as fault tolerance. The common design technique of a signature analyzer for mixed-signal systems is based on the rules of an arithmetic finite field. The application of this technique to the systems with an arbitrary radix is a challenging task and the devices designed possess high hardware complexity. The proposed technique is simple and applicable to systems of any size and radix. The hardware complexity is low. The technique can also be used in arithmetic/algebraic coding and cryptography.

  9. Proteomes of the barley aleurone layer: A model system for plant signalling and protein secretion

    DEFF Research Database (Denmark)

    Finnie, Christine; Andersen, Birgit; Shahpiri, Azar

    2011-01-01

    molecules in an isolated system. These properties have led to its use as a model system for the study of plant signalling and germination. More recently, proteome analysis of the aleurone layer has provided new insight into this unique tissue including identification of plasma membrane proteins and targeted...... analysis of germination-related changes and the thioredoxin system. Here, analysis of intracellular and secreted proteomes reveals features of the aleurone layer system that makes it promising for investigations of plant protein secretion mechanisms....... to gibberellic acid produced by the embryo, the aleurone layer synthesises hydrolases that are secreted to the endosperm for the degradation of storage products. The barley aleurone layer can be separated from the other seed tissues and maintained in culture, allowing the study of the effect of added signalling...

  10. Small-Signal Stability of Wind Power System With Full-Load Converter Interfaced Wind Turbines

    DEFF Research Database (Denmark)

    Knüppel, Thyge; Nielsen, Jørgen Nygaard; Jensen, Kim Høj

    2012-01-01

    Small-signal stability analysis of power system oscillations is a well established field within power system analysis, but not much attention has yet been paid to systems with a high penetration of wind turbines and with large wind power plants (WPP). In this paper a comprehensive analysis...... is presented which assesses the impact of full-load converter interfaced wind turbines on power system small-signal stability. The study is based on a 7 generator network with lightly damped inter-area modes. A detailed wind turbine (WT) model with all grid relevant control functions is used in the study....... The WT is, furthermore, equipped with a park level WPP voltage controller and comparisons are presented. The WT model for this work is a validated dynamic model of the 3.6 MW Siemens Wind Power WT. The study is based on modal analysis which is complemented with time domain simulations on the nonlinear...

  11. Experience with a PC-based system for noise and DC signal analysis in PWRs

    International Nuclear Information System (INIS)

    Hashemian, H.M.

    1996-01-01

    A data acquisition system that was originally developed for noise diagnostics in PWRs was expanded to include DC signal analysis in addition to noise analysis. The system has been used in PWRs for reactor diagnostics, determination of root cause of process anomalies, instrument calibration verification, measurement of drop time of control and shutdown rods, testing of timing and sequencing of control rod drive mechanisms, emergency diesel generator monitoring, etc. These applications are reviewed in this paper. (author)

  12. FPGA-based GEM detector signal acquisition for SXR spectroscopy system

    Science.gov (United States)

    Wojenski, A.; Pozniak, K. T.; Kasprowicz, G.; Kolasinski, P.; Krawczyk, R.; Zabolotny, W.; Chernyshova, M.; Czarski, T.; Malinowski, K.

    2016-11-01

    The presented work is related to the Gas Electron Multiplier (GEM) detector soft X-ray spectroscopy system for tokamak applications. The used GEM detector has one-dimensional, 128 channel readout structure. The channels are connected to the radiation-hard electronics with configurable analog stage and fast ADCs, supporting speeds of 125 MSPS for each channel. The digitalized data is sent directly to the FPGAs using fast serial links. The preprocessing algorithms are implemented in the FPGAs, with the data buffering made in the on-board 2Gb DDR3 memory chips. After the algorithmic stage, the data is sent to the Intel Xeon-based PC for further postprocessing using PCI-Express link Gen 2. For connection of multiple FPGAs, PCI-Express switch 8-to-1 was designed. The whole system can support up to 2048 analog channels. The scope of the work is an FPGA-based implementation of the recorder of the raw signal from GEM detector. Since the system will work in a very challenging environment (neutron radiation, intense electro-magnetic fields), the registered signals from the GEM detector can be corrupted. In the case of the very intense hot plasma radiation (e.g. laser generated plasma), the registered signals can overlap. Therefore, it is valuable to register the raw signals from the GEM detector with high number of events during soft X-ray radiation. The signal analysis will have the direct impact on the implementation of photon energy computation algorithms. As the result, the system will produce energy spectra and topological distribution of soft X-ray radiation. The advanced software was developed in order to perform complex system startup and monitoring of hardware units. Using the array of two one-dimensional GEM detectors it will be possible to perform tomographic reconstruction of plasma impurities radiation in the SXR region.

  13. Cloning of a two-component signal transduction system of Xanthomonas campestris pv. phaseoli var. fuscans strain BXPF65

    DEFF Research Database (Denmark)

    Chan, JWYF; Maynard, Scott; Goodwin, PH

    1998-01-01

    A putative two-component signal transduction system was amplified and cloned from the plant pathogenic bacterium Xanthomonas campestris pv. phaseoli var. fuscans isolate BXPF65. The 620 bp amplified fragment was sequenced and analyzed with the BLAST Enhanced Alignment Utility (BEAUTY). BEAUTY...... that the putative histidine kinase has homology with conserved “transmitter” domains of sensor proteins in two-component signal transduction systems. RFLP analysis using the putative signal transduction system showed polymorphisms among the strains....

  14. Signal processing approaches to secure physical layer communications in multi-antenna wireless systems

    CERN Document Server

    Hong, Y-W Peter; Kuo, C-C Jay

    2013-01-01

    This book introduces various signal processing approaches to enhance physical layer secrecy in multi-antenna wireless systems. Wireless physical layer secrecy has attracted much attention in recent years due to the broadcast nature of the wireless medium and its inherent vulnerability to eavesdropping. While most articles on physical layer secrecy focus on the information-theoretic aspect, we focus specifically on the signal processing aspects, including beamforming and precoding techniques for data transmission and discriminatory training schemes for channel estimation. The discussions will c

  15. Formal techniques for a data-driven certification of advanced railway signalling systems

    DEFF Research Database (Denmark)

    Fantechi, Alessandro

    2016-01-01

    The technological evolution of railway signalling equipment promises significant increases in transport capacity, in operation regularity, in quality and safety of the service offered.This evolution is based on the massive use of computer control units on board trains and on the ground, that aims...... at improving the performance of rail transport and maintaining high safety figures.A brief review of possible innovation trends of signalling systems shows that they will be more and more based on the exchange of accurate and secure complex information, in order to ensure safe operation.For this reason we want...

  16. Viability of a Bioelectrical Signal Acquisition System Energized by Cellphone with NFC.

    Science.gov (United States)

    Kay, Marcel Seiji; Iaione, Fábio

    2015-01-01

    Currently, smartphones are used in various systems in the medical field due to the presence of various features, notably Near Field Communication (NFC). NFC utilizes communication technology and an energy supply based on electromagnetic induction. One of the most common medical tests is the electrocardiogram (ECG), through which various heart diseases can be diagnosed. The objective of this study is to evaluate the feasibility of providing power to a bioelectrical signal acquisition module using a mobile phone with NFC. After testing it was indicated that it is possible to construct a passive module to acquire ECG signals using NFC mobile phone.

  17. Adaptive synchronization of fractional Lorenz systems using a reduced number of control signals and parameters

    International Nuclear Information System (INIS)

    Aguila-Camacho, Norelys; Duarte-Mermoud, Manuel A.; Delgado-Aguilera, Efredy

    2016-01-01

    This paper analyzes the synchronization of two fractional Lorenz systems in two cases: the first one considering fractional Lorenz systems with unknown parameters, and the second one considering known upper bounds on some of the fractional Lorenz systems parameters. The proposed control strategies use a reduced number of control signals and control parameters, employing mild assumptions. The stability of the synchronization errors is analytically demonstrated in all cases, and the convergence to zero of the synchronization errors is analytically proved in the case when the upper bounds on some system parameters are assumed to be known. Simulation studies are presented, which allows verifying the effectiveness of the proposed control strategies.

  18. Fish protection at water intakes using a new signal development process and sound system

    International Nuclear Information System (INIS)

    Loeffelman, P.H.; Klinect, D.A.; Van Hassel, J.H.

    1991-01-01

    American Electric Power Company, Inc., is exploring the feasibility of using a patented signal development process and sound system to guide aquatic animals with underwater sound. Sounds from animals such as chinook salmon, steelhead trout, striped bass, freshwater drum, largemouth bass, and gizzard shad can be used to synthesize a new signal to stimulate the animal in the most sensitive portion of its hearing range. AEP's field tests during its research demonstrate that adult chinook salmon, steelhead trout and warmwater fish, and steelhead trout and chinook salmon smolts can be repelled with a properly-tuned system. The signal development process and sound system is designed to be transportable and use animals at the site to incorporate site-specific factors known to affect underwater sound, e.g., bottom shape and type, water current, and temperature. This paper reports that, because the overall goal of this research was to determine the feasibility of using sound to divert fish, it was essential that the approach use a signal development process which could be customized to animals and site conditions at any hydropower plant site

  19. Vehicle speed guidance strategy at signalized intersection based on cooperative vehicle infrastructure system

    Directory of Open Access Journals (Sweden)

    Fengyuan JIA

    2017-10-01

    Full Text Available In order to reduce stopping time of vehicle at a signalized intersection, aiming at the difficulty, even the impossibility to obtain real-time queue length of intersection in third and fourth-tier cities in China sometimes, a speed guidance strategy based on cooperative vehicle infrastructure system is put forward and studied. For validating the strategy, the traffic signal timing data of the intersection at Hengshan Road and North Fengming Lake Road in Wuhu is collected by a vehicular traffic signal reminder system which is designed. The simulation experiments using the acquired data are done by software VISSIM. The simulation results demonstrate that the strategy under high and low traffic flow can effectively decrease the link travel-time, reducing average ratio is 9.2 % and 13.0 %, respectively, and the effect under low traffic flow is better than that under high traffic flow. The strategy improves efficiency of traffic at a signalized intersection and provides an idea for the application of vehicle speed guidance based on cooperative vehicle infrastructure system.

  20. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance.

    Science.gov (United States)

    Park, Sang-Wook; Kaimoyo, Evans; Kumar, Dhirendra; Mosher, Stephen; Klessig, Daniel F

    2007-10-05

    In plants, the mobile signal for systemic acquired resistance (SAR), an organism-wide state of enhanced defense to subsequent infections, has been elusive. By stimulating immune responses in mosaic tobacco plants created by grafting different genetic backgrounds, we showed that the methyl salicylate (MeSA) esterase activity of salicylic acid-binding protein 2 (SABP2), which converts MeSA into salicylic acid (SA), is required for SAR signal perception in systemic tissue, the tissue that does not receive the primary (initial) infection. Moreover, in plants expressing mutant SABP2 with unregulated MeSA esterase activity in SAR signal-generating, primary infected leaves, SAR was compromised and the associated increase in MeSA levels was suppressed in primary infected leaves, their phloem exudates, and systemic leaves. SAR was also blocked when SA methyl transferase (which converts SA to MeSA) was silenced in primary infected leaves, and MeSA treatment of lower leaves induced SAR in upper untreated leaves. Therefore, we conclude that MeSA is a SAR signal in tobacco.

  1. System and method for constructing filters for detecting signals whose frequency content varies with time

    Science.gov (United States)

    Qian, S.; Dunham, M.E.

    1996-11-12

    A system and method are disclosed for constructing a bank of filters which detect the presence of signals whose frequency content varies with time. The present invention includes a novel system and method for developing one or more time templates designed to match the received signals of interest and the bank of matched filters use the one or more time templates to detect the received signals. Each matched filter compares the received signal x(t) with a respective, unique time template that has been designed to approximate a form of the signals of interest. The robust time domain template is assumed to be of the order of w(t)=A(t)cos(2{pi}{phi}(t)) and the present invention uses the trajectory of a joint time-frequency representation of x(t) as an approximation of the instantaneous frequency function {phi}{prime}(t). First, numerous data samples of the received signal x(t) are collected. A joint time frequency representation is then applied to represent the signal, preferably using the time frequency distribution series. The joint time-frequency transformation represents the analyzed signal energy at time t and frequency f, P(t,f), which is a three-dimensional plot of time vs. frequency vs. signal energy. Then P(t,f) is reduced to a multivalued function f(t), a two dimensional plot of time vs. frequency, using a thresholding process. Curve fitting steps are then performed on the time/frequency plot, preferably using Levenberg-Marquardt curve fitting techniques, to derive a general instantaneous frequency function {phi}{prime}(t) which best fits the multivalued function f(t). Integrating {phi}{prime}(t) along t yields {phi}{prime}(t), which is then inserted into the form of the time template equation. A suitable amplitude A(t) is also preferably determined. Once the time template has been determined, one or more filters are developed which each use a version or form of the time template. 7 figs.

  2. Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling.

    Science.gov (United States)

    Brankatschk, Marko; Dunst, Sebastian; Nemetschke, Linda; Eaton, Suzanne

    2014-10-02

    The Insulin signaling pathway couples growth, development and lifespan to nutritional conditions. Here, we demonstrate a function for the Drosophila lipoprotein LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signaling. When yeast lipids are present in the diet, free calcium levels rise in Blood Brain Barrier glial cells. This induces transport of LTP across the Blood Brain Barrier by two LDL receptor-related proteins: LRP1 and Megalin. LTP accumulates on specific neurons that connect to cells that produce Insulin-like peptides, and induces their release into the circulation. This increases systemic Insulin signaling and the rate of larval development on yeast-containing food compared with a plant-based food of similar nutritional content.

  3. FPGA based hardware optimized implementation of signal processing system for LFM pulsed radar

    Science.gov (United States)

    Azim, Noor ul; Jun, Wang

    2016-11-01

    Signal processing is one of the main parts of any radar system. Different signal processing algorithms are used to extract information about different parameters like range, speed, direction etc, of a target in the field of radar communication. This paper presents LFM (Linear Frequency Modulation) pulsed radar signal processing algorithms which are used to improve target detection, range resolution and to estimate the speed of a target. Firstly, these algorithms are simulated in MATLAB to verify the concept and theory. After the conceptual verification in MATLAB, the simulation is converted into implementation on hardware using Xilinx FPGA. Chosen FPGA is Xilinx Virtex-6 (XC6LVX75T). For hardware implementation pipeline optimization is adopted and also other factors are considered for resources optimization in the process of implementation. Focusing algorithms in this work for improving target detection, range resolution and speed estimation are hardware optimized fast convolution processing based pulse compression and pulse Doppler processing.

  4. Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System

    Directory of Open Access Journals (Sweden)

    Alessandro Cannavo

    2017-08-01

    Full Text Available The sphingosine kinases 1 and 2 (SphK1 and 2 catalyze the phosphorylation of the lipid, sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P. The activation of such kinases and the subsequent S1P generation and secretion in the blood serum of mammals represent a major checkpoint in many cellular signaling cascades. In fact, activating the SphK/S1P system is critical for cell motility and proliferation, cytoskeletal organization, cell growth, survival, and response to stress. In the cardiovascular system, the physiological effects of S1P intervene through the binding and activation of a family of five highly selective G protein-coupled receptors, called S1PR1-5. Importantly, SphK/S1P signal is present on both vascular and myocardial cells. S1P is a well-recognized survival factor in many tissues. Therefore, it is not surprising that the last two decades have seen a flourishing of interest and investigative efforts directed to obtain additional mechanistic insights into the signaling, as well as the biological activity of this phospholipid, and of its receptors, especially in the cardiovascular system. Here, we will provide an up-to-date account on the structure and function of sphingosine kinases, discussing the generation, release, and function of S1P. Keeping the bull’s eye on the cardiovascular system, we will review the structure and signaling cascades and biological actions emanating from the stimulation of different S1P receptors. We will end this article with a summary of the most recent, experimental and clinical observations targeting S1PRs and SphKs as possible new therapeutic avenues for cardiovascular disorders, such as heart failure.

  5. Novel textile systems for the continuous monitoring of vital signals: design and characterization.

    Science.gov (United States)

    Trindade, Isabel G; Martins, Frederico; Dias, Rúben; Oliveira, Cristina; Machado da Silva, José

    2015-08-01

    In this article we present a smart textile system for the continuous monitoring of cardiorespiratory signals, produced and integrated with an industrial embroidery unit. The design of a T-shirt system, having embedded textile sensors and interconnects and custom designed circuit for data collection and Bluetooth transmission is presented. The performance of skin-contact textile electrodes, having distinctive electrical characteristics and surface morphologies, was characterized by measurements of signal to noise ratio, under dry and moisture conditions. The influence of the electrodes size and the wear resistance were addressed. Results of an electrocardiogram acquisition with a subject wearing the T-shirt and display on a smartphone are also shown. The presented smart textile systems exhibit good performance and versatility for custom demand production.

  6. An Analysis/Synthesis System of Audio Signal with Utilization of an SN Model

    Directory of Open Access Journals (Sweden)

    G. Rozinaj

    2004-12-01

    Full Text Available An SN (sinusoids plus noise model is a spectral model, in which theperiodic components of the sound are represented by sinusoids withtime-varying frequencies, amplitudes and phases. The remainingnon-periodic components are represented by a filtered noise. Thesinusoidal model utilizes physical properties of musical instrumentsand the noise model utilizes the human inability to perceive the exactspectral shape or the phase of stochastic signals. SN modeling can beapplied in a compression, transformation, separation of sounds, etc.The designed system is based on methods used in the SN modeling. Wehave proposed a model that achieves good results in audio perception.Although many systems do not save phases of the sinusoids, they areimportant for better modelling of transients, for the computation ofresidual and last but not least for stereo signals, too. One of thefundamental properties of the proposed system is the ability of thesignal reconstruction not only from the amplitude but from the phasepoint of view, as well.

  7. Automatic Mitigation of Sensor Variations for Signal Strength Based Location Systems

    DEFF Research Database (Denmark)

    Kjærgaard, Mikkel Baun

    2006-01-01

    n the area of pervasive computing a key concept is context-awareness. One type of context information is location information of wireless network clients. Research in indoor localization of wireless network clients based on signal strength is receiving a lot of attention. However, not much...... of this research is directed towards handling the issue of adapting a signal strength based indoor localization system to the hardware and software of a specific wireless network client, be it a tag, PDA or laptop. Therefore current indoor localization systems need to be manually adapted to work optimally...... with specific hardware and software. A second problem is that for a specific hardware there will be more than one driver available and they will have different properties when used for localization. Therefore the contribution of this paper is twofold. First, an automatic system for evaluating the fitness...

  8. A new signal development process and sound system for diverting fish from water intakes

    International Nuclear Information System (INIS)

    Klinet, D.A.; Loeffelman, P.H.; van Hassel, J.H.

    1992-01-01

    This paper reports that American Electric Power Service Corporation has explored the feasibility of using a patented signal development process and underwater sound system to divert fish away from water intake areas. The effect of water intakes on fish is being closely scrutinized as hydropower projects are re-licensed. The overall goal of this four-year research project was to develop an underwater guidance system which is biologically effective, reliable and cost-effective compared to other proposed methods of diversion, such as physical screens. Because different fish species have various listening ranges, it was essential to the success of this experiment that the sound system have a great amount of flexibility. Assuming a fish's sounds are heard by the same kind of fish, it was necessary to develop a procedure and acquire instrumentation to properly analyze the sounds that the target fish species create to communicate and any artificial signals being generated for diversion

  9. The high accuracy data processing system of laser interferometry signals based on MSP430

    Science.gov (United States)

    Qi, Yong-yue; Lin, Yu-chi; Zhao, Mei-rong

    2009-07-01

    Generally speaking there are two orthogonal signals used in single-frequency laser interferometer for differentiating direction and electronic subdivision. However there usually exist three errors with the interferential signals: zero offsets error, unequal amplitude error and quadrature phase shift error. These three errors have a serious impact on subdivision precision. Based on Heydemann error compensation algorithm, it is proposed to achieve compensation of the three errors. Due to complicated operation of the Heydemann mode, a improved arithmetic is advanced to decrease the calculating time effectively in accordance with the special characteristic that only one item of data will be changed in each fitting algorithm operation. Then a real-time and dynamic compensatory circuit is designed. Taking microchip MSP430 as the core of hardware system, two input signals with the three errors are turned into digital quantity by the AD7862. After data processing in line with improved arithmetic, two ideal signals without errors are output by the AD7225. At the same time two original signals are turned into relevant square wave and imported to the differentiating direction circuit. The impulse exported from the distinguishing direction circuit is counted by the timer of the microchip. According to the number of the pulse and the soft subdivision the final result is showed by LED. The arithmetic and the circuit are adopted to test the capability of a laser interferometer with 8 times optical path difference and the measuring accuracy of 12-14nm is achieved.

  10. Property-Based Monitoring of Analog and Mixed-Signal Systems

    Science.gov (United States)

    Havlicek, John; Little, Scott; Maler, Oded; Nickovic, Dejan

    In the recent past, there has been a steady growth of the market for consumer embedded devices such as cell phones, GPS and portable multimedia systems. In embedded systems, digital, analog and software components are combined on a single chip, resulting in increasingly complex designs that introduce richer functionality on smaller devices. As a consequence, the potential insertion of errors into a design becomes higher, yielding an increasing need for automated analog and mixed-signal validation tools. In the purely digital setting, formal verification based on properties expressed in industrial specification languages such as PSL and SVA is nowadays successfully integrated in the design flow. On the other hand, the validation of analog and mixed-signal systems still largely depends on simulation-based, ad-hoc methods. In this tutorial, we consider some ingredients of the standard verification methodology that can be successfully exported from digital to analog and mixed-signal setting, in particular property-based monitoring techniques. Property-based monitoring is a lighter approach to the formal verification, where the system is seen as a "black-box" that generates sets of traces, whose correctness is checked against a property, that is its high-level specification. Although incomplete, monitoring is effectively used to catch faults in systems, without guaranteeing their full correctness.

  11. Fractal Communication System Using Digital Signal Processing Starter Kit (DSK TMS320c6713

    Directory of Open Access Journals (Sweden)

    Arsyad Ramadhan Darlis

    2015-12-01

    Full Text Available In 1992, Wornell and Oppenheim did research on a modulation which is formed by using wavelet theory. In some other studies, proved that this modulation can survive on a few channels and has reliability in some applications. Because of this modulation using the concept of fractal, then it is called as fractalmodulation. Fractal modulation is formed by inserting information signal into fractal signals that are selffractal similary. This modulation technique has the potential to replace the OFDM (Orthogonal Frequency Division Multiplexing, which is currently used on some of the latest telecommunication technologies. The purpose of this research is to implement the fractal communication system using Digital Signal Processing Starter Kit (DSK TMS320C6713 without using AWGN and Rayleigh channel in order to obtain the ideal performance of the system. From the simulation results using MATLAB7.4. it appears that this communication system has good performance on some channels than any other communication systems. While in terms of implementation by using (DSK via TMS320C6713 Code Composer Studio (CCS, it can be concluded that thefractal communication system has a better execution time on some tests.

  12. Received Signal Strength Database Interpolation by Kriging for a Wi-Fi Indoor Positioning System.

    Science.gov (United States)

    Jan, Shau-Shiun; Yeh, Shuo-Ju; Liu, Ya-Wen

    2015-08-28

    The main approach for a Wi-Fi indoor positioning system is based on the received signal strength (RSS) measurements, and the fingerprinting method is utilized to determine the user position by matching the RSS values with the pre-surveyed RSS database. To build a RSS fingerprint database is essential for an RSS based indoor positioning system, and building such a RSS fingerprint database requires lots of time and effort. As the range of the indoor environment becomes larger, labor is increased. To provide better indoor positioning services and to reduce the labor required for the establishment of the positioning system at the same time, an indoor positioning system with an appropriate spatial interpolation method is needed. In addition, the advantage of the RSS approach is that the signal strength decays as the transmission distance increases, and this signal propagation characteristic is applied to an interpolated database with the Kriging algorithm in this paper. Using the distribution of reference points (RPs) at measured points, the signal propagation model of the Wi-Fi access point (AP) in the building can be built and expressed as a function. The function, as the spatial structure of the environment, can create the RSS database quickly in different indoor environments. Thus, in this paper, a Wi-Fi indoor positioning system based on the Kriging fingerprinting method is developed. As shown in the experiment results, with a 72.2% probability, the error of the extended RSS database with Kriging is less than 3 dBm compared to the surveyed RSS database. Importantly, the positioning error of the developed Wi-Fi indoor positioning system with Kriging is reduced by 17.9% in average than that without Kriging.

  13. A PC-based signal validation system for nuclear power plants

    International Nuclear Information System (INIS)

    Erbay, A.S.; Upadhyaya, B.R.; Seker, S.

    1998-01-01

    In order to achieve the desired operating configuration in any process, the system conditions must be measured accurately. Examples of measurements are temperature, pressure, flow, level, motor current, vibration, etc. However, in order to operate within desired limits, it is important to know the reliability of plant measurements. Signal validation (SV) deals with this issue, and is defined as the detection, isolation and characterization of faulty signals. Also referred to as fault detection, signal validation checks inconsistencies among redundant measurements and estimates their expected values using other measurements and system models. The benefits of SV are both economic and safety related. Catastrophic signal failure can result in plant shutdown and lost revenue. Pre-catastrophic failure detection would therefore minimize plant downtime and increase plant availability. The control action taken depends primarily upon the information provided by the plant instruments. Thus, increased plant productivity and increased reliability of operator actions, would result from the implementation of such a system. The purpose of this study is to investigate some of the existing signal validation methods by incremental improvements and to develop new modules. Each of the SV modules performs a specific task. The architecture consists of four modules, an information base and a system executive integrated with a graphical user interface (GUI). All the modules are used for validation during both steady-state and transient operating conditions. The entire system was developed in the PC-framework under Microsoft Windows TM . Some improvements were made in the structure of static data-driven models by incorporating one and two-step regression. Kalman filtering is based on the use of a physical model of plant components and was implemented for a steam generator system in a nuclear power plant. This is applicable to both steady-state and transient operations. The system executive

  14. EXPERIMENTAL STUDY OF FIRMWARE FOR INPUT AND EXTRACTION OF USER’S VOICE SIGNAL IN VOICE AUTHENTICATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    O. N. Faizulaieva

    2014-09-01

    Full Text Available Scientific task for improving the signal-to-noise ratio for user’s voice signal in computer systems and networks during the process of user’s voice authentication is considered. The object of study is the process of input and extraction of the voice signal of authentication system user in computer systems and networks. Methods and means for input and extraction of the voice signal on the background of external interference signals are investigated. Ways for quality improving of the user’s voice signal in systems of voice authentication are investigated experimentally. Firmware means for experimental unit of input and extraction of the user’s voice signal against external interference influence are considered. As modern computer means, including mobile, have two-channel audio card, two microphones are used in the voice signal input. The distance between sonic-wave sensors is 20 mm and it provides forming one direction pattern lobe of microphone array in a desired area of voice signal registration (from 100 Hz to 8 kHz. According to the results of experimental studies, the usage of directional properties of the proposed microphone array and space-time processing of the recorded signals with implementation of constant and adaptive weighting factors has made it possible to reduce considerably the influence of interference signals. The results of firmware experimental studies for input and extraction of the user’s voice signal against external interference influence are shown. The proposed solutions will give the possibility to improve the value of the signal/noise ratio of the useful signals recorded up to 20 dB under the influence of external interference signals in the frequency range from 4 to 8 kHz. The results may be useful to specialists working in the field of voice recognition and speaker discrimination.

  15. Deployment and Field Evaluation of In-Vehicle Traffic Signal Advisory System (ITSAS

    Directory of Open Access Journals (Sweden)

    Joyoung Lee

    2017-06-01

    Full Text Available This research evaluates the impact of In-vehicle Signal Advisory System (ITSAS on signalized arterial. ITSAS provides individual drivers equipped with a mobile communication device with advisory speed information enabling to minimize the time delay and fuel consumption when crossing intersection. Given the instantaneous vehicular driving information, such as position, speed, and acceleration rate, ITSAS produces advisory speed information by taking into consideration the traffic signal changes at a downstream intersection. The advisory speed information includes not only an optimal speed range updated every 300-ft for individual drivers but also a descriptive message to warn drivers stop to ensure safety at the downstream intersection. Unlike other similar Connected Vehicles applications for intersection management, ITSAS does not require Roadside Equipment (RSE to disseminate the advisory speed information as it is designed to exploit commercial cellular network service (i.e., 3G and 4G-LTE. Thus, ITSAS can be easily plugged into existing traffic control management system to rapidly conduct its implementation without significant additional cost. This research presents the field evaluations of ITSAS on a signalized corridor in New Jersey, which discovered significant travel time savings for the equipped vehicle.

  16. A High Performance Pocket-Size System for Evaluations in Acoustic Signal Processing

    Directory of Open Access Journals (Sweden)

    Steeger Gerhard H

    2001-01-01

    Full Text Available Custom-made hardware is attractive for sophisticated signal processing in wearable electroacoustic devices, but has a high initial cost overhead. Thus, signal processing algorithms should be tested thoroughly in real application environments by potential end users prior to the hardware implementation. In addition, the algorithms should be easily alterable during this test phase. A wearable system which meets these requirements has been developed and built. The system is based on the high performance signal processor Motorola DSP56309. This device also includes high quality stereo analog-to-digital-(ADC- and digital-to-analog-(DAC-converters with 20 bit word length each. The available dynamic range exceeds 88 dB. The input and output gains can be adjusted by digitally controlled potentiometers. The housing of the unit is small enough to carry it in a pocket (dimensions 150 × 80 × 25 mm. Software tools have been developed to ease the development of new algorithms. A set of configurable Assembler code modules implements all hardware dependent software routines and gives easy access to the peripherals and interfaces. A comfortable fitting interface allows easy control of the signal processing unit from a PC, even by assistant personnel. The device has proven to be a helpful means for development and field evaluations of advanced new hearing aid algorithms, within interdisciplinary research projects. Now it is offered to the scientific community.

  17. Improved Reception of In-Body Signals by Means of a Wearable Multi-Antenna System

    Directory of Open Access Journals (Sweden)

    Thijs Castel

    2013-01-01

    Full Text Available High data-rate wireless communication for in-body human implants is mainly performed in the 402–405 MHz Medical Implant Communication System band and the 2.45 GHz Industrial, Scientific and Medical band. The latter band offers larger bandwidth, enabling high-resolution live video transmission. Although in-body signal attenuation is larger, at least 29 dB more power may be transmitted in this band and the antenna efficiency for compact antennas at 2.45 GHz is also up to 10 times higher. Moreover, at the receive side, one can exploit the large surface provided by a garment by deploying multiple compact highly efficient wearable antennas, capturing the signals transmitted by the implant directly at the body surface, yielding stronger signals and reducing interference. In this paper, we implement a reliable 3.5 Mbps wearable textile multi-antenna system suitable for integration into a jacket worn by a patient, and evaluate its potential to improve the In-to-Out Body wireless link reliability by means of spatial receive diversity in a standardized measurement setup. We derive the optimal distribution and the minimum number of on-body antennas required to ensure signal levels that are large enough for real-time wireless endoscopy-capsule applications, at varying positions and orientations of the implant in the human body.

  18. Enzyme-sharing as a cause of multi-stationarity in signalling systems

    DEFF Research Database (Denmark)

    Feliu, Elisenda; Wiuf, Carsten

    2012-01-01

    Multi-stationarity in biological systems is a mechanism of cellular decision-making. In particular, signalling pathways regulated by protein phosphorylation display features that facilitate a variety of responses to different biological inputs. The features that lead to multi-stationarity are of ......Multi-stationarity in biological systems is a mechanism of cellular decision-making. In particular, signalling pathways regulated by protein phosphorylation display features that facilitate a variety of responses to different biological inputs. The features that lead to multi......-stationarity are of particular interest to determine, as well as the stability, properties of the steady states. In this paper, we determine conditions for the emergence of multi-stationarity in small motifs without feedback that repeatedly occur in signalling pathways. We derive an explicit mathematical relationship ¿ between...... identify characteristics of the motifs that lead to multi-stationarity, and extend the view that multi-stationarity in signalling pathways arises from multi-site phosphorylation. Our approach relies on mass-action kinetics, and the conclusions are drawn in full generality without resorting to simulations...

  19. Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity?

    Science.gov (United States)

    Reich, Arno; Spering, Christopher; Schulz, Jörg B

    2008-09-01

    For over a decade, neuroscientific research has focused on processes of apoptosis and its contribution to the pathophysiology of neurological diseases. In the central nervous system, the degree of intrinsic mitochondrial-mediated apoptotic signaling expresses a cell's individual metabolic stress, whereas activation of the extrinsic death receptor-induced cascade is regarded as a sign of imbalanced cellular networks. Under physiological conditions, most neurons possess death receptors without being sensitive to receptor-mediated apoptosis. This paradox raises two questions: what is the evolutionary advantage of expressing potentially harmful proteins? How is their signaling controlled? This review summarizes the functional relevance of FasL-Fas signaling--a quintessential death ligand/receptor system--in different neurological disease models ranging from traumatic, inflammatory and ischemic to neurodegenerative processes. Furthermore, it outlines alternative non-apoptotic Fas signaling, shedding new light on its neuroplastic capacity. Finally, receptor-proximal regulatory proteins are introduced and identified as potential protagonists of disease-modifying neurological therapies.

  20. Hydrological deformation signals in karst systems: new evidence from the European Alps

    Science.gov (United States)

    Serpelloni, E.; Pintori, F.; Gualandi, A.; Scoccimarro, E.; Cavaliere, A.; Anderlini, L.; Belardinelli, M. E.; Todesco, M.

    2017-12-01

    The influence of rainfall on crustal deformation has been described at local scales, using tilt and strain meters, in several tectonic settings. However, the literature on the spatial extent of rainfall-induced deformation is still scarce. We analyzed 10 years of displacement time-series from 150 continuous GPS stations operating across the broad zone of deformation accommodating the N-S Adria-Eurasia convergence and the E-ward escape of the Eastern Alps toward the Pannonian basin. We applied a blind-source-separation algorithm based on a variational Bayesian Independent Component Analysis method to the de-trended time-series, being able to characterize the temporal and spatial features of several deformation signals. The most important ones are a common mode annual signal, with spatially uniform response in the vertical and horizontal components and a time-variable, non-cyclic, signal characterized by a spatially variable response in the horizontal components, with stations moving (up to 8 mm) in the opposite directions, reversing the sense of movement in time. This implies a succession of extensional/compressional strains, with variable amplitudes through time, oriented normal to rock fractures in karst areas. While seasonal displacements in the vertical component (with an average amplitude of 4 mm over the study area) are satisfactorily reproduced by surface hydrological loading, estimated from global assimilation models, the non seasonal signal is associated with groundwater flow in karst systems, and is mainly influencing the horizontal component. The temporal evolution of this deformation signal is correlated with cumulated precipitation values over periods of 200-300 days. This horizontal deformation can be explained by pressure changes associated with variable water levels within vertical fractures in the vadose zones of karst systems, and the water level changes required to open or close these fractures are consistent with the fluctuations of precipitation

  1. Development of a compact and cost effective multi-input digital signal processing system

    Science.gov (United States)

    Darvish-Molla, Sahar; Chin, Kenrick; Prestwich, William V.; Byun, Soo Hyun

    2018-01-01

    A prototype digital signal processing system (DSP) was developed using a microcontroller interfaced with a 12-bit sampling ADC, which offers a considerably inexpensive solution for processing multiple detectors with high throughput. After digitization of the incoming pulses, in order to maximize the output counting rate, a simple algorithm was employed for pulse height analysis. Moreover, an algorithm aiming at the real-time pulse pile-up deconvolution was implemented. The system was tested using a NaI(Tl) detector in comparison with a traditional analogue and commercial digital systems for a variety of count rates. The performance of the prototype system was consistently superior to the analogue and the commercial digital systems up to the input count rate of 61 kcps while was slightly inferior to the commercial digital system but still superior to the analogue system in the higher input rates. Considering overall cost, size and flexibility, this custom made multi-input digital signal processing system (MMI-DSP) was the best reliable choice for the purpose of the 2D microdosimetric data collection, or for any measurement in which simultaneous multi-data collection is required.

  2. Development of FPGA-based digital signal processing system for radiation spectroscopy

    International Nuclear Information System (INIS)

    Lee, Pil Soo; Lee, Chun Sik; Lee, Ju Hahn

    2013-01-01

    We have developed an FPGA-based digital signal processing system that performs both online digital signal filtering and pulse-shape analysis for both particle and gamma-ray spectroscopy. Such functionalities were made possible by a state-of-the-art programmable logic device and system architectures employed. The system performance as measured, for example, in the system dead time and accuracy for pulse-height and rise-time determination, was evaluated with standard alpha- and gamma-ray sources using a CsI(Tl) scintillation detector. It is resulted that the present system has shown its potential application to various radiation-related fields such as particle identification, radiography, and radiation imaging. - Highlights: ► An FPGA-based digital processing system was developed for radiation spectroscopy. ► Our digital system has a 14-bit resolution and a 100-MHz sampling rate. ► The FPGA implements the online digital filtering and pulse-shape analysis. ► The pileup rejection is implemented in trigger logic before digital filtering process. ► Our digital system was verified in alpha-gamma measurements using a CsI detector

  3. MATHEMATICAL MODELING OF THE UNPUT DEVICES IN AUTOMATIC LOCOMOTIVE SIGNALING SYSTEM

    Directory of Open Access Journals (Sweden)

    O. O. Gololobova

    2014-03-01

    Full Text Available Purpose. To examine the operation of the automatic locomotive signaling system (ALS, to find out the influence of external factors on the devices operation and the quality of the code information derived from track circuit information, as well as to enable modeling of failure occurrences that may appear during operation. Methodology. To achieve this purpose, the main obstacles in ALS operation and the reasons for their occurrence were considered and the system structure principle was researched. The mathematical model for input equipment of the continuous automatic locomotive signaling system (ALS with the number coding was developed. It was designed taking into account all the types of code signals “R”, “Y”, “RY” and equivalent scheme of replacing the filter with a frequency of 50 Hz. Findings. The operation of ALSN with a signal current frequency of 50 Hz was examined. The adequate mathematical model of input equipment of ALS with a frequency of 50 Hz was developed. Originality. The computer model of input equipment of ALS system in the environment of MATLAB+Simulink was developed. The results of the computer modeling on the outlet of the filter during delivering every type of code combination were given in the article. Practical value. With the use of developed mathematical model of ALS system operation we have an opportunity to study, research and determine behavior of the circuit during the normal operation mode and failure occurrences. Also there is a possibility to develop and apply different scheme decisions in modeling environment MATLAB+Simulink for reducing the influence of obstacles on the functional capability of ALS and to model the occurrence of possible difficulties.

  4. Urban Traffic Signal System Control Structural Optimization Based on Network Analysis

    Directory of Open Access Journals (Sweden)

    Li Wang

    2013-01-01

    Full Text Available Advanced urban traffic signal control systems such as SCOOT and SCATS normally coordinate traffic network using multilevel hierarchical control mechanism. In this mechanism, several key intersections will be selected from traffic signal network and the network will be divided into different control subareas. Traditionally, key intersection selection and control subareas division are executed according to dynamic traffic counts and link length between intersections, which largely rely on traffic engineers’ experience. However, it omits important inherent characteristics of traffic network topology. In this paper, we will apply network analysis approach into these two aspects for traffic system control structure optimization. Firstly, the modified C-means clustering algorithm will be proposed to assess the importance of intersections in traffic network and furthermore determine the key intersections based on three indexes instead of merely on traffic counts in traditional methods. Secondly, the improved network community discovery method will be used to give more reasonable evidence in traffic control subarea division. Finally, to test the effectiveness of network analysis approach, a hardware-in-loop simulation environment composed of regional traffic control system, microsimulation software and signal controller hardware, will be built. Both traditional method and proposed approach will be implemented on simulation test bed to evaluate traffic operation performance indexes, for example, travel time, stop times, delay and average vehicle speed. Simulation results show that the proposed network analysis approach can improve the traffic control system operation performance effectively.

  5. A fast continuous magnetic field measurement system based on digital signal processors

    Energy Technology Data Exchange (ETDEWEB)

    Velev, G.V.; Carcagno, R.; DiMarco, J.; Kotelnikov, S.; Lamm, M.; Makulski, A.; /Fermilab; Maroussov, V.; /Purdue U.; Nehring, R.; Nogiec, J.; Orris, D.; /Fermilab; Poukhov,; Prakoshyn, F.; /Dubna, JINR; Schlabach, P.; Tompkins, J.C.; /Fermilab

    2005-09-01

    In order to study dynamic effects in accelerator magnets, such as the decay of the magnetic field during the dwell at injection and the rapid so-called ''snapback'' during the first few seconds of the resumption of the energy ramp, a fast continuous harmonics measurement system was required. A new magnetic field measurement system, based on the use of digital signal processors (DSP) and Analog to Digital (A/D) converters, was developed and prototyped at Fermilab. This system uses Pentek 6102 16 bit A/D converters and the Pentek 4288 DSP board with the SHARC ADSP-2106 family digital signal processor. It was designed to acquire multiple channels of data with a wide dynamic range of input signals, which are typically generated by a rotating coil probe. Data acquisition is performed under a RTOS, whereas processing and visualization are performed under a host computer. Firmware code was developed for the DSP to perform fast continuous readout of the A/D FIFO memory and integration over specified intervals, synchronized to the probe's rotation in the magnetic field. C, C++ and Java code was written to control the data acquisition devices and to process a continuous stream of data. The paper summarizes the characteristics of the system and presents the results of initial tests and measurements.

  6. A fast continuous magnetic field measurement system based on digital signal processors

    International Nuclear Information System (INIS)

    Velev, G.V.; Carcagno, R.; DiMarco, J.; Kotelnikov, S.; Lamm, M.; Makulski, A.; Maroussov, V.; Nehring, R.; Nogiec, J.; Orris, D.; Poukhov, O.; Prakoshyn, F.; Schlabach, P.; Tompkins, J.C.

    2005-01-01

    In order to study dynamic effects in accelerator magnets, such as the decay of the magnetic field during the dwell at injection and the rapid so-called ''snapback'' during the first few seconds of the resumption of the energy ramp, a fast continuous harmonics measurement system was required. A new magnetic field measurement system, based on the use of digital signal processors (DSP) and Analog to Digital (A/D) converters, was developed and prototyped at Fermilab. This system uses Pentek 6102 16 bit A/D converters and the Pentek 4288 DSP board with the SHARC ADSP-2106 family digital signal processor. It was designed to acquire multiple channels of data with a wide dynamic range of input signals, which are typically generated by a rotating coil probe. Data acquisition is performed under a RTOS, whereas processing and visualization are performed under a host computer. Firmware code was developed for the DSP to perform fast continuous readout of the A/D FIFO memory and integration over specified intervals, synchronized to the probe's rotation in the magnetic field. C, C++ and Java code was written to control the data acquisition devices and to process a continuous stream of data. The paper summarizes the characteristics of the system and presents the results of initial tests and measurements

  7. Enhancement of the conductivity detection signal in capillary electrophoresis systems using neutral cyclodextrins as sweeping agents.

    Science.gov (United States)

    Boublík, Milan; Riesová, Martina; Dubský, Pavel; Gaš, Bohuslav

    2018-06-01

    Conductivity detection is a universal detection technique often encountered in electrophoretic separation systems, especially in modern chip-electrophoresis based devices. On the other hand, it is sparsely combined with another contemporary trend of enhancing limits of detection by means of various preconcentration strategies. This can be attributed to the fact that a preconcentration experimental setup usually brings about disturbances in a conductivity baseline. Sweeping with a neutral sweeping agent seems a good candidate for overcoming this problem. A neutral sweeping agent does not hinder the conductivity detection while a charged analyte may preconcentrate on its boundary due to a decrease in its effective mobility. This study investigates such sweeping systems theoretically, by means of computer simulations, and experimentally. A formula is provided for the reliable estimation of the preconcentration factor. Additionally, it is demonstrated that the conductivity signal can significantly benefit from slowing down the analyte and thus the overall signal enhancement can easily overweight amplification caused solely by the sweeping process. The overall enhancement factor can be deduced a priori from the linearized theory of electrophoresis implemented in the PeakMaster freeware. Sweeping by neutral cyclodextrin is demonstrated on an amplification of a conductivity signal of flurbiprofen in a real drug sample. Finally, a possible formation of unexpected system peaks in systems with a neutral sweeping agent is revealed by the computer simulation and confirmed experimentally. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Systemic control of brown fat thermogenesis: integration of peripheral and central signals.

    Science.gov (United States)

    Schulz, Tim J; Tseng, Yu-Hua

    2013-10-01

    Brown adipose tissue (BAT) is of great scientific interest as a potential target to treat obesity. The development of novel strategies to quantify brown fat thermogenesis in adult humans now enables minimally invasive assessment of novel pharmacotherapeutics. Input from the central nervous system via sympathetic efferents is widely regarded as the key controller of BAT-mediated thermogenesis in response to changes in body temperature or nutrient availability. More recently, however, it has become clear that locally secreted signals and endocrine factors originating from multiple organs can control the recruitment of brown adipocytes and, more importantly, induce thermogenesis in brown fat. Thus, they provide an attractive strategy to fine-tune brown fat thermogenesis independent of classical temperature sensing. Here, we summarize recent findings on bone morphogenetic protein signaling as an example of secreted factors in the regulation of brown adipocyte formation and systemic control of energy metabolism. We further highlight endocrine communication routes between the different types of brown adipocytes and other organs that contribute to regulation of thermogenesis. Thus, emerging evidence suggests that the classical mechanisms of central temperature sensing and sympathetic nervous system-driven thermogenesis are complemented by local and endocrine signals to determine systemic energy homeostasis. © 2013 New York Academy of Sciences.

  9. System and method for earth probing with deep subsurface penetration using low frequency electromagnetic signals

    International Nuclear Information System (INIS)

    Etten, P. van; Brown, R.D.

    1996-01-01

    An earth probing system uses deep penetration of electromagnetic waves into soil and other media. Advantage is taken of lower attenuation of radar in soil by frequencies of about three megahertz or less. Bursts of electromagnetic energy of various frequencies in this range are consecutively transmitted. The transmitting antenna is continuously tuned, so as to maintain resonance during each burst, allowing large circulating currents and high power output. In a receiving antenna system, a dual antenna arrangement is providing for obtaining improved reception. A corresponding dual antenna circuit employs 'a spatial notch filtering', automatic adjustment of antenna gain-frequency variations, as well as compensation for transmitter gain variation. The system may be implemented in a totally analog, totally digital, or hybrid manner. Preferably, a signal processing method detected and digitally samples signal reflected from subsurface layers and buried objects. The invention provides means for removing system distortions and interfering signals, for compensating for aliasing errors and frequency-dependent antenna gain and phase variations, and for avoiding masking errors introduced by strong reflections. (author)

  10. Comparative of signal processing techniques for micro-Doppler signature extraction with automotive radar systems

    Science.gov (United States)

    Rodriguez-Hervas, Berta; Maile, Michael; Flores, Benjamin C.

    2014-05-01

    In recent years, the automotive industry has experienced an evolution toward more powerful driver assistance systems that provide enhanced vehicle safety. These systems typically operate in the optical and microwave regions of the electromagnetic spectrum and have demonstrated high efficiency in collision and risk avoidance. Microwave radar systems are particularly relevant due to their operational robustness under adverse weather or illumination conditions. Our objective is to study different signal processing techniques suitable for extraction of accurate micro-Doppler signatures of slow moving objects in dense urban environments. Selection of the appropriate signal processing technique is crucial for the extraction of accurate micro-Doppler signatures that will lead to better results in a radar classifier system. For this purpose, we perform simulations of typical radar detection responses in common driving situations and conduct the analysis with several signal processing algorithms, including short time Fourier Transform, continuous wavelet or Kernel based analysis methods. We take into account factors such as the relative movement between the host vehicle and the target, and the non-stationary nature of the target's movement. A comparison of results reveals that short time Fourier Transform would be the best approach for detection and tracking purposes, while the continuous wavelet would be the best suited for classification purposes.

  11. The Role of Thyroid Hormone Signaling in the Prevention of Digestive System Cancers

    Directory of Open Access Journals (Sweden)

    Rosalia C. M. Simmen

    2013-08-01

    Full Text Available Thyroid hormones play a critical role in the growth and development of the alimentary tract in vertebrates. Their effects are mediated by nuclear receptors as well as the cell surface receptor integrin αVβ3. Systemic thyroid hormone levels are controlled via activation and deactivation by iodothyronine deiodinases in the liver and other tissues. Given that thyroid hormone signaling has been characterized as a major effector of digestive system growth and homeostasis, numerous investigations have examined its role in the occurrence and progression of cancers in various tissues of this organ system. The present review summarizes current findings regarding the effects of thyroid hormone signaling on cancers of the esophagus, stomach, liver, pancreas, and colon. Particular attention is given to the roles of different thyroid hormone receptor isoforms, the novel integrin αVβ3 receptor, and thyroid hormone-related nutrients as possible protective agents and therapeutic targets. Future investigations geared towards a better understanding of thyroid hormone signaling in digestive system cancers may provide preventive or therapeutic strategies to diminish risk, improve outcome and avert recurrence in afflicted individuals.

  12. Elabela-apelin receptor signaling pathway is functional in mammalian systems.

    Science.gov (United States)

    Wang, Zhi; Yu, Daozhan; Wang, Mengqiao; Wang, Qilong; Kouznetsova, Jennifer; Yang, Rongze; Qian, Kun; Wu, Wenjun; Shuldiner, Alan; Sztalryd, Carole; Zou, Minghui; Zheng, Wei; Gong, Da-Wei

    2015-02-02

    Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal development of heart and vasculature through activation of apelin receptor (APJ), a G protein-coupled receptor (GPCR), in zebrafish. The present study explores whether the ELA-APJ signaling pathway is functional in the mammalian system. Using reverse-transcription PCR, we found that ELA is restrictedly expressed in human pluripotent stem cells and adult kidney whereas APJ is more widely expressed. We next studied ELA-APJ signaling pathway in reconstituted mammalian cell systems. Addition of ELA to HEK293 cells over-expressing GFP-AJP fusion protein resulted in rapid internalization of the fusion receptor. In Chinese hamster ovarian (CHO) cells over-expressing human APJ, ELA suppresses cAMP production with EC50 of 11.1 nM, stimulates ERK1/2 phosphorylation with EC50 of 14.3 nM and weakly induces intracellular calcium mobilization. Finally, we tested ELA biological function in human umbilical vascular endothelial cells and showed that ELA induces angiogenesis and relaxes mouse aortic blood vessel in a dose-dependent manner through a mechanism different from apelin. Collectively, we demonstrate that the ELA-AJP signaling pathways are functional in mammalian systems, indicating that ELA likely serves as a hormone regulating the circulation system in adulthood as well as in embryonic development.

  13. Influence of Wind Plant Ancillary Voltage Control on System Small Signal Stability

    DEFF Research Database (Denmark)

    Su, Chi; Chen, Zhe

    2012-01-01

    As a common tendency, large-scale wind farms are increasingly connected to the transmission system of modern power grids. This introduces some new challenges to the connected power systems, and the transmission system operators (TSOs) have to put some new requirements as part of the grid codes...... on the integration of wind farms. One common requirement to wind farms is the function of system voltage control which can be implemented in the grid-side convertor controller of a variable speed wind turbine. This ancillary voltage control provided by wind farms could have some influence on the system small signal...... stability. This paper implements an ancillary voltage control strategy on a direct-drive-full-convertor-based wind farm and studies its influence on the damping ratio values of the dominant oscillation mode within the connected power system. All the calculations and simulations are conducted in DIg...

  14. Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins

    NARCIS (Netherlands)

    Hendriks-Balk, Mariëlle C.; Peters, Stephan L. M.; Michel, Martin C.; Alewijnse, Astrid E.

    2008-01-01

    G protein-coupled receptors (GPCRs) are involved in many biological processes. Therefore, GPCR function is tightly controlled both at receptor level and at the level of signalling components. Well-known mechanisms by which GPCR function can be regulated comprise desensitization/resensitization

  15. V2I-based startup assistance system at signalized intersections

    Directory of Open Access Journals (Sweden)

    Jianqiang Wang

    2015-08-01

    Full Text Available Traffic delays are caused by unskilled vehicle operation and driver distraction during the startup process at signalized intersections. To address this issue, we propose a V2I-based driver assistance system that can acquire the current traffic signal status and provide drivers with startup assistance. This article presents the proposed system’s architecture and an assistance algorithm, which contains two types of driver assistance methods: startup prompting and automatic startup control. The automatic startup control method, based on fuzzy logic control, is validated in simulation tests. We also implement startup prompting using a prototype system and validate its performance in field tests. The test results suggest that the proposed assistance algorithm can help drivers start up their vehicles with less delay, which will significantly improve traffic efficiency.

  16. A harmonic coil measurement system based on a dynamic signal acquisition device

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, J.X., E-mail: zhoujx@ihep.ac.c [Institute of High Energy Physics, P.O. Box 918-9, Beijing 100049 (China); Li, L.; Yin, B.G.; Deng, C.D.; Kang, W.; Chen, Y.; Zhang, Z.; Fu, S.N. [Institute of High Energy Physics, P.O. Box 918-9, Beijing 100049 (China)

    2010-12-21

    A new harmonic coil measurement system based on a dynamic signal acquisition device has been successfully developed to check the field quality of the quadrupole magnet for the CSNS/RCS, which operates at the 25 Hz excitation cycle with a DC bias. It was designed to acquire multiple channels of data with a wide dynamic range of input signals, which are typically generated by a harmonic coil and an encoder. A dedicated algorithm was developed in LabView code to identify over specified intervals, synchronized to the coil's rotation in the magnetic field. Through full integration of hardware and software, the traditional device (PDI 5025) is replaced successfully. This paper summarizes the characteristics of the system and presents the results of DC measurements.

  17. Measurements and Simulations of Ionization Chamber Signals in Mixed Radiation Fields for the LHC BLM System

    CERN Document Server

    Dehning, B; Ferioli, G; Holzer, EB; Stockner, M

    2006-01-01

    The LHC beam loss monitoring (BLM) system must prevent the super conducting magnets from quenching and protect the machine components from damage. The main monitor type is an ionization chamber. About 4000 of them will be installed around the ring. The lost beam particles initiate hadronic showers through the magnets, which are measured by the monitors installed outside of the cryostat around each quadrupole magnet. They probe the far transverse tail of the hadronic shower. The specification for the BLM system includes a factor of two absolute precision on the prediction of the quench levels. To reach this accuracy a number of simulations are being combined to calibrate the monitor signals. To validate the monitor calibration the simulations are compared with test measurements. This paper will focus on the simulated prediction of the development of the hadronic shower tails and the signal response of ionization chambers to various particle types and energies. Test measurements have been performed at CERN and ...

  18. It pays to cheat: tactical deception in a cephalopod social signalling system.

    Science.gov (United States)

    Brown, Culum; Garwood, Martin P; Williamson, Jane E

    2012-10-23

    Signals in intraspecific communication should be inherently honest; otherwise the system is prone to collapse. Theory predicts, however, that honest signalling systems are susceptible to invasion by cheats, the extent of which is largely mediated by fear of reprisal. Cuttlefish facultatively change their shape and colour, an ability that evolved to avoid predators and capture prey. Here, we show that this ability is tactically employed by male mourning cuttlefish (Sepia plangon) to mislead conspecifics during courtship in a specific social context amenable to cheating 39 per cent of the time, while it was never employed in other social contexts. Males deceive rival males by displaying male courtship patterns to receptive females on one side of the body, and simultaneously displaying female patterns to a single rival male on the other, thus preventing the rival from disrupting courtship. The use of tactical deception in such a complex communication network indicates that sociality has played a key role in the cognitive evolution of cephalopods.

  19. Reducing Downlink Signaling Traffic in Wireless Systems Using Mobile-Assisted Scheduling

    OpenAIRE

    Moosavi, Reza; Larsson, Erik G.

    2010-01-01

    We present an idea to reduce the part of the downlink signaling traffic in wireless multiple access systems that contains scheduling information. The theoretical basis of the scheme is that the scheduling decisions made by the base station are correlated with the CSI reports from the mobiles. This correlation can be exploited by the source coding scheme that is used to compress the scheduling maps before they are sent to the mobiles. In the proposed scheme, this idea is implemented by letting...

  20. BioSig: A bioinformatic system for studying the mechanism of intra-cell signaling

    OpenAIRE

    Parvin, B.; Cong, G.; Fontenay, G.; Taylor, J.; Henshall, R.; Barcellos-Hoff, M.H.

    2000-01-01

    Mapping inter-cell signaling pathways requires an integrated view of experimental and informatic protocols. BioSig provides the foundation of cataloging inter-cell responses as a function of particular conditioning, treatment, staining, etc. for either in vivo or in vitro experiments. This paper outlines the system architecture, a functional data model for representing experimental protocols, algorithms for image analysis, and the requried statistical analysis. The architecture provides...

  1. Signals transmission via RF systems in a sewage treatment plant; Signaluebertragung via Funk im Klaerwerk

    Energy Technology Data Exchange (ETDEWEB)

    Brasas, Joerg [Phoenix Contact Electronics GmbH, Bad Pyrmont (Germany)

    2010-06-15

    The Niersverband is a municipal utility located at Viersen, Germany. It covers an area that is more or less identical with the catchment area of the Niers river and the Niers canal. There are 23 sewage treatment plants, rainwater retention basins and pumping stations transporting the collected water to the sewage treatment plants. For signal transmission between the stations, a Trusted Wireless system via Profibus-DP is used. (orig.)

  2. Test results of the signal processing and amplifier unit for the emittance measurement system

    International Nuclear Information System (INIS)

    Stawiszynski, L.; Schneider, S.

    1984-01-01

    The signal processing and amplifier unit for the emittance measurement system is the unit with which the beam current on the harp-wires and the slit is measured and converted to a digital output. Temperature effects are very critical at low currents and the purpose of the test measurements described in this report was mainly to establish the accuracy and repeatability of the measurements under the influence of temperature variations

  3. Deciphering the hormonal signalling network behind the systemic resistance induced by Trichoderma harzianum in tomato

    Science.gov (United States)

    Martínez-Medina, Ainhoa; Fernández, Iván; Sánchez-Guzmán, María J.; Jung, Sabine C.; Pascual, Jose A.; Pozo, María J.

    2013-01-01

    Root colonization by selected Trichoderma isolates can activate in the plant a systemic defense response that is effective against a broad-spectrum of plant pathogens. Diverse plant hormones play pivotal roles in the regulation of the defense signaling network that leads to the induction of systemic resistance triggered by beneficial organisms [induced systemic resistance (ISR)]. Among them, jasmonic acid (JA) and ethylene (ET) signaling pathways are generally essential for ISR. However, Trichoderma ISR (TISR) is believed to involve a wider variety of signaling routes, interconnected in a complex network of cross-communicating hormone pathways. Using tomato as a model, an integrative analysis of the main mechanisms involved in the systemic resistance induced by Trichoderma harzianum against the necrotrophic leaf pathogen Botrytis cinerea was performed. Root colonization by T. harzianum rendered the leaves more resistant to B. cinerea independently of major effects on plant nutrition. The analysis of disease development in shoots of tomato mutant lines impaired in the synthesis of the key defense-related hormones JA, ET, salicylic acid (SA), and abscisic acid (ABA), and the peptide prosystemin (PS) evidenced the requirement of intact JA, SA, and ABA signaling pathways for a functional TISR. Expression analysis of several hormone-related marker genes point to the role of priming for enhanced JA-dependent defense responses upon pathogen infection. Together, our results indicate that although TISR induced in tomato against necrotrophs is mainly based on boosted JA-dependent responses, the pathways regulated by the plant hormones SA- and ABA are also required for successful TISR development. PMID:23805146

  4. International Conference on VLSI, Communication, Advanced Devices, Signals & Systems and Networking

    CERN Document Server

    Shirur, Yasha; Prasad, Rekha

    2013-01-01

    This book is a collection of papers presented by renowned researchers, keynote speakers and academicians in the International Conference on VLSI, Communication, Analog Designs, Signals and Systems, and Networking (VCASAN-2013), organized by B.N.M. Institute of Technology, Bangalore, India during July 17-19, 2013. The book provides global trends in cutting-edge technologies in electronics and communication engineering. The content of the book is useful to engineers, researchers and academicians as well as industry professionals.

  5. Systems biology of adipose tissue metabolism: regulation of growth, signaling and inflammation.

    Science.gov (United States)

    Manteiga, Sara; Choi, Kyungoh; Jayaraman, Arul; Lee, Kyongbum

    2013-01-01

    Adipose tissue (AT) depots actively regulate whole body energy homeostasis by orchestrating complex communications with other physiological systems as well as within the tissue. Adipocytes readily respond to hormonal and nutritional inputs to store excess nutrients as intracellular lipids or mobilize the stored fat for utilization. Co-ordinated regulation of metabolic pathways balancing uptake, esterification, and hydrolysis of lipids is accomplished through positive and negative feedback interactions of regulatory hubs comprising several pleiotropic protein kinases and nuclear receptors. Metabolic regulation in adipocytes encompasses biogenesis and remodeling of uniquely large lipid droplets (LDs). The regulatory hubs also function as energy and nutrient sensors, and integrate metabolic regulation with intercellular signaling. Over-nutrition causes hypertrophic expansion of adipocytes, which, through incompletely understood mechanisms, initiates a cascade of metabolic and signaling events leading to tissue remodeling and immune cell recruitment. Macrophage activation and polarization toward a pro-inflammatory phenotype drives a self-reinforcing cycle of pro-inflammatory signals in the AT, establishing an inflammatory state. Sustained inflammation accelerates lipolysis and elevates free fatty acids in circulation, which robustly correlates with development of obesity-related diseases. The adipose regulatory network coupling metabolism, growth, and signaling of multiple cell types is exceedingly complex. While components of the regulatory network have been individually studied in exquisite detail, systems approaches have rarely been utilized to comprehensively assess the relative engagements of the components. Thus, need and opportunity exist to develop quantitative models of metabolic and signaling networks to achieve a more complete understanding of AT biology in both health and disease. Copyright © 2013 Wiley Periodicals, Inc.

  6. Linearmycins Activate a Two-Component Signaling System Involved in Bacterial Competition and Biofilm Morphology

    Science.gov (United States)

    2017-01-01

    ABSTRACT Bacteria use two-component signaling systems to adapt and respond to their competitors and changing environments. For instance, competitor bacteria may produce antibiotics and other bioactive metabolites and sequester nutrients. To survive, some species of bacteria escape competition through antibiotic production, biofilm formation, or motility. Specialized metabolite production and biofilm formation are relatively well understood for bacterial species in isolation. How bacteria control these functions when competitors are present is not well studied. To address fundamental questions relating to the competitive mechanisms of different species, we have developed a model system using two species of soil bacteria, Bacillus subtilis and Streptomyces sp. strain Mg1. Using this model, we previously found that linearmycins produced by Streptomyces sp. strain Mg1 cause lysis of B. subtilis cells and degradation of colony matrix. We identified strains of B. subtilis with mutations in the two-component signaling system yfiJK operon that confer dual phenotypes of specific linearmycin resistance and biofilm morphology. We determined that expression of the ATP-binding cassette (ABC) transporter yfiLMN operon, particularly yfiM and yfiN, is necessary for biofilm morphology. Using transposon mutagenesis, we identified genes that are required for YfiLMN-mediated biofilm morphology, including several chaperones. Using transcriptional fusions, we found that YfiJ signaling is activated by linearmycins and other polyene metabolites. Finally, using a truncated YfiJ, we show that YfiJ requires its transmembrane domain to activate downstream signaling. Taken together, these results suggest coordinated dual antibiotic resistance and biofilm morphology by a single multifunctional ABC transporter promotes competitive fitness of B. subtilis. IMPORTANCE DNA sequencing approaches have revealed hitherto unexplored diversity of bacterial species in a wide variety of environments that

  7. The design of photoelectric signal processing system for a nuclear magnetic resonance gyroscope based on FPGA

    Science.gov (United States)

    Zhang, Xian; Zhou, Binquan; Li, Hong; Zhao, Xinghua; Mu, Weiwei; Wu, Wenfeng

    2017-10-01

    Navigation technology is crucial to the national defense and military, which can realize the measurement of orientation, positioning, attitude and speed for moving object. Inertial navigation is not only autonomous, real-time, continuous, hidden, undisturbed but also no time-limited and environment-limited. The gyroscope is the core component of the inertial navigation system, whose precision and size are the bottleneck of the performance. However, nuclear magnetic resonance gyroscope is characteristic of the advantage of high precision and small size. Nuclear magnetic resonance gyroscope can meet the urgent needs of high-tech weapons and equipment development of new generation. This paper mainly designs a set of photoelectric signal processing system for nuclear magnetic resonance gyroscope based on FPGA, which process and control the information of detecting laser .The photoelectric signal with high frequency carrier is demodulated by in-phase and quadrature demodulation method. Finally, the processing system of photoelectric signal can compensate the residual magnetism of the shielding barrel and provide the information of nuclear magnetic resonance gyroscope angular velocity.

  8. Investigation of signal models and methods for evaluating structures of processing telecommunication information exchange systems under acoustic noise conditions

    Science.gov (United States)

    Kropotov, Y. A.; Belov, A. A.; Proskuryakov, A. Y.; Kolpakov, A. A.

    2018-05-01

    The paper considers models and methods for estimating signals during the transmission of information messages in telecommunication systems of audio exchange. One-dimensional probability distribution functions that can be used to isolate useful signals, and acoustic noise interference are presented. An approach to the estimation of the correlation and spectral functions of the parameters of acoustic signals is proposed, based on the parametric representation of acoustic signals and the components of the noise components. The paper suggests an approach to improving the efficiency of interference cancellation and highlighting the necessary information when processing signals from telecommunications systems. In this case, the suppression of acoustic noise is based on the methods of adaptive filtering and adaptive compensation. The work also describes the models of echo signals and the structure of subscriber devices in operational command telecommunications systems.

  9. Stochastic Signal Processing for Sound Environment System with Decibel Evaluation and Energy Observation

    Directory of Open Access Journals (Sweden)

    Akira Ikuta

    2014-01-01

    Full Text Available In real sound environment system, a specific signal shows various types of probability distribution, and the observation data are usually contaminated by external noise (e.g., background noise of non-Gaussian distribution type. Furthermore, there potentially exist various nonlinear correlations in addition to the linear correlation between input and output time series. Consequently, often the system input and output relationship in the real phenomenon cannot be represented by a simple model using only the linear correlation and lower order statistics. In this study, complex sound environment systems difficult to analyze by using usual structural method are considered. By introducing an estimation method of the system parameters reflecting correlation information for conditional probability distribution under existence of the external noise, a prediction method of output response probability for sound environment systems is theoretically proposed in a suitable form for the additive property of energy variable and the evaluation in decibel scale. The effectiveness of the proposed stochastic signal processing method is experimentally confirmed by applying it to the observed data in sound environment systems.

  10. Hierarchical Colored Petri Nets for Modeling and Analysis of Transit Signal Priority Control Systems

    Directory of Open Access Journals (Sweden)

    Yisheng An

    2018-01-01

    Full Text Available In this paper, we consider the problem of developing a model for traffic signal control with transit priority using Hierarchical Colored Petri nets (HCPN. Petri nets (PN are useful for state analysis of discrete event systems due to their powerful modeling capability and mathematical formalism. This paper focuses on their use to formalize the transit signal priority (TSP control model. In a four-phase traffic signal control model, the transit detection and two kinds of transit priority strategies are integrated to obtain the HCPN-based TSP control models. One of the advantages to use these models is the clear presentation of traffic light behaviors in terms of conditions and events that cause the detection of a priority request by a transit vehicle. Another advantage of the resulting models is that the correctness and reliability of the proposed strategies are easily analyzed. After their full reachable states are generated, the boundness, liveness, and fairness of the proposed models are verified. Experimental results show that the proposed control model provides transit vehicles with better effectiveness at intersections. This work helps advance the state of the art in the design of signal control models related to the intersection of roadways.

  11. A Discrete Dynamical System Approach to Pathway Activation Profiles of Signaling Cascades.

    Science.gov (United States)

    Catozzi, S; Sepulchre, J-A

    2017-08-01

    In living organisms, cascades of covalent modification cycles are one of the major intracellular signaling mechanisms, allowing to transduce physical or chemical stimuli of the external world into variations of activated biochemical species within the cell. In this paper, we develop a novel method to study the stimulus-response of signaling cascades and overall the concept of pathway activation profile which is, for a given stimulus, the sequence of activated proteins at each tier of the cascade. Our approach is based on a correspondence that we establish between the stationary states of a cascade and pieces of orbits of a 2D discrete dynamical system. The study of its possible phase portraits in function of the biochemical parameters, and in particular of the contraction/expansion properties around the fixed points of this discrete map, as well as their bifurcations, yields a classification of the cascade tiers into three main types, whose biological impact within a signaling network is examined. In particular, our approach enables to discuss quantitatively the notion of cascade amplification/attenuation from this new perspective. The method allows also to study the interplay between forward and "retroactive" signaling, i.e., the upstream influence of an inhibiting drug bound to the last tier of the cascade.

  12. Evolution of Signaling in a Multi-Robot System: Categorization and Communication

    Science.gov (United States)

    Ampatzis, Christos; Tuci, Elio; Trianni, Vito; Dorigo, Marco

    We use Evolutionary Robotics to design robot controllers in which decision-making mechanisms to switch from solitary to social behavior are integrated with the mechanisms that underpin the sensory-motor repertoire of the robots. In particular, we study the evolution of behavioral and communicative skills in a categorization task. The individual decision-making structures are based on the integration over time of sensory information. The mechanisms for switching from solitary to social behavior and the ways in which the robots can affect each other's behavior are not predetermined by the experimenter, but are aspects of our model designed by artificial evolution. Our results show that evolved robots manage to cooperate and collectively discriminate between different environments by developing a simple communication protocol based on sound signaling. Communication emerges in the absence of explicit selective pressure coded in the fitness function. The evolution of communication is neither trivial nor obvious; for a meaningful signaling system to evolve, evolution must produce both appropriate signals and appropriate reactions to signals. The use of communication proves to be adaptive for the group, even if, in principle, non-cooperating robots can be equally successful with cooperating robots.

  13. Spectrum sharing opportunities of full-duplex systems using improper Gaussian signaling

    KAUST Repository

    Gaafar, Mohamed

    2015-08-01

    Sharing the licensed spectrum of full-duplex (FD) primary users (PU) brings strict limitations on the underlay cognitive radio operation. Particularly, the self interference may overwhelm the PU receiver and limit the opportunity of secondary users (SU) to access the spectrum. Improper Gaussian signaling (IGS) has demonstrated its superiority in improving the performance of interference channel systems. Throughout this paper, we assume a FD PU pair that uses proper Gaussian signaling (PGS), and a half-duplex SU pair that uses IGS. The objective is to maximize the SU instantaneous achievable rate while meeting the PU quality-of-service. To this end, we propose a simplified algorithm that optimizes the SU signal parameters, i.e, the transmit power and the circularity coefficient, which is a measure of the degree of impropriety of the SU signal, to achieve the design objective. Numerical results show the merits of adopting IGS compared with PGS for the SU especially with the existence of week PU direct channels and/or strong SU interference channels.

  14. On the optimal sampling of bandpass measurement signals through data acquisition systems

    International Nuclear Information System (INIS)

    Angrisani, L; Vadursi, M

    2008-01-01

    Data acquisition systems (DAS) play a fundamental role in a lot of modern measurement solutions. One of the parameters characterizing a DAS is its maximum sample rate, which imposes constraints on the signals that can be alias-free digitized. Bandpass sampling theory singles out separated ranges of admissible sample rates, which can be significantly lower than carrier frequency. But, how to choose the most convenient sample rate according to the purpose at hand? The paper proposes a method for the automatic selection of the optimal sample rate in measurement applications involving bandpass signals; the effects of sample clock instability and limited resolution are also taken into account. The method allows the user to choose the location of spectral replicas of the sampled signal in terms of normalized frequency, and the minimum guard band between replicas, thus introducing a feature that no DAS currently available on the market seems to offer. A number of experimental tests on bandpass digitally modulated signals are carried out to assess the concurrence of the obtained central frequency with the expected one

  15. A Dynamical System Exhibits High Signal-to-noise Ratio Gain by Stochastic Resonance

    Science.gov (United States)

    Makra, Peter; Gingl, Zoltan

    2003-05-01

    On the basis of mixed-signal simulations, we demonstrate that signal-to-noise ratio (SNR) gains much greater than unity can be obtained in the double-well potential through stochastic resonance (SR) with a symmetric periodic pulse train as deterministic and Gaussian white noise as random excitation. We also show that significant SNR improvement is possible in this system even for a sub-threshold sinusoid input if, instead of the commonly used narrow-band SNR, we apply an equally simple but much more realistic wide-band SNR definition. Using the latter result as an argument, we draw attention to the fact that the choice of the measure to reflect signal quality is critical with regard to the extent of signal improvement observed, and urge reconsideration of the practice prevalent in SR studies that most often the narrow-band SNR is used to characterise SR. Finally, we pose some questions concerning the possibilities of applying SNR improvement in practical set-ups.

  16. Self-repair in a Bidirectionally Coupled Astrocyte-Neuron (AN System based on Retrograde Signaling

    Directory of Open Access Journals (Sweden)

    John eWade

    2012-09-01

    Full Text Available In this paper we demonstrate that retrograde signaling via astrocytes may underpin self-repair in the brain. Faults manifest themselves in silent or near silent neurons caused by low transmission probability synapses; the enhancement of the transmission probability of a healthy neighbouring synapse by retrograde signaling can enhance the transmission probability of the faulty synapse (repair. Our model of self-repair is based on recent research showing that retrograde signaling via astrocytes can increase the probability of neurotransmitter release at damaged or low transmission probability synapses. The model demonstrates that astrocytes are capable of bidirectional communication with neurons which leads to modulation of synaptic activity, and that indirect signaling through retrograde messengers such as endocannabinoids leads to modulation of synaptic transmission probability. Although our model operates at the level of cells, it provides a new research direction on brain-like self-repair which can be extended to networks of astrocytes and neurons. It also provides a biologically inspired basis for developing highly adaptive, distributed computing systems that can, at fine levels of granularity, fault detect, diagnose and self-repair autonomously, without the traditional constraint of a central fault detect/repair unit.

  17. An EEG-Based Person Authentication System with Open-Set Capability Combining Eye Blinking Signals.

    Science.gov (United States)

    Wu, Qunjian; Zeng, Ying; Zhang, Chi; Tong, Li; Yan, Bin

    2018-01-24

    The electroencephalogram (EEG) signal represents a subject's specific brain activity patterns and is considered as an ideal biometric given its superior forgery prevention. However, the accuracy and stability of the current EEG-based person authentication systems are still unsatisfactory in practical application. In this paper, a multi-task EEG-based person authentication system combining eye blinking is proposed, which can achieve high precision and robustness. Firstly, we design a novel EEG-based biometric evoked paradigm using self- or non-self-face rapid serial visual presentation (RSVP). The designed paradigm could obtain a distinct and stable biometric trait from EEG with a lower time cost. Secondly, the event-related potential (ERP) features and morphological features are extracted from EEG signals and eye blinking signals, respectively. Thirdly, convolutional neural network and back propagation neural network are severally designed to gain the score estimation of EEG features and eye blinking features. Finally, a score fusion technology based on least square method is proposed to get the final estimation score. The performance of multi-task authentication system is improved significantly compared to the system using EEG only, with an increasing average accuracy from 92.4% to 97.6%. Moreover, open-set authentication tests for additional imposters and permanence tests for users are conducted to simulate the practical scenarios, which have never been employed in previous EEG-based person authentication systems. A mean false accepted rate (FAR) of 3.90% and a mean false rejected rate (FRR) of 3.87% are accomplished in open-set authentication tests and permanence tests, respectively, which illustrate the open-set authentication and permanence capability of our systems.

  18. Improvement of emotional healthcare system with stress detection from ECG signal.

    Science.gov (United States)

    Tivatansakul, S; Ohkura, M

    2015-01-01

    Our emotional healthcare system is designed to cope with users' negative emotions in daily life. To make the system more intelligent, we integrated emotion recognition by facial expression to provide appropriate services based on user's current emotional state. Our emotion recognition by facial expression has confusion issue to recognize some positive, neutral and negative emotions that make the emotional healthcare system provide a relaxation service even though users don't have negative emotions. Therefore, to increase the effectiveness of the system to provide the relaxation service, we integrate stress detection from ECG signal. The stress detection might be able to address the confusion issue of emotion recognition by facial expression to provide the service. Indeed, our results show that integration of stress detection increases the effectiveness and efficiency of the emotional healthcare system to provide services.

  19. An efficient digital signal processing method for RRNS-based DS-CDMA systems

    Directory of Open Access Journals (Sweden)

    Peter Olsovsky

    2017-09-01

    Full Text Available This paper deals with an efficient method for achieving low power and high speed in advanced Direct-Sequence Code Division Multiple-Access (DS-CDMA wireless communication systems based on the Residue Number System (RNS. A modified algorithm for multiuser DS-CDMA signal generation in MATLAB is proposed and investigated. The most important characteristics of the generated PN code are also presented. Subsequently, a DS-CDMA system based on the combination of the RNS or the so-called Redundant Residue Number System (RRNS is proposed. The enhanced method using a spectrally efficient 8-PSK data modulation scheme to improve the bandwidth efficiency for RRNS-based DS-CDMA systems is presented. By using the C-measure (complexity measure of the error detection function, it is possible to estimate the size of the circuit. Error detection function in RRNSs can be efficiently implemented by LookUp Table (LUT cascades.

  20. Deciphering the hormonal signalling network behind the systemic resistance induced by Trichoderma harzianum in tomato

    Directory of Open Access Journals (Sweden)

    Ainhoa eMartinez-Medina

    2013-06-01

    Full Text Available Root colonization by selected Trichoderma isolates can activate in the plant a systemic defence response that is effective against a broad spectrum of plant pathogens. Diverse plant hormones play pivotal roles in the regulation of the defence signalling network that leads to the induction of systemic resistance triggered by beneficial organisms (ISR. Among them, jasmonic acid (JA and ethylene (ET signalling pathways are generally essential for ISR. However, Trichoderma ISR (TISR is believed to involve a wider variety of signalling routes, interconnected in a complex network of cross-communicating hormone pathways. Using tomato as a model, an integrative analysis of the main mechanisms involved in the systemic resistance induced by Trichoderma harzianum against the necrotrophic leaf pathogen Botrytis cinerea was performed. Root colonization by T. harzianum rendered the leaves more resistant to B. cinerea independently of major effects on plant nutrition. The analysis of disease development in shoots of tomato mutant lines impaired in the synthesis of the key defence related hormones JA, ET, salicylic acid (SA and abscisic acid (ABA and the peptide prosystemin (PS evidenced the requirement of intact JA, SA and ABA signalling pathways for a functional TISR. Expression analysis of several hormone related marker genes point to the role of priming for enhanced JA-dependent defence responses upon pathogen infection. Together, our results indicate that although TISR induced in tomato against the necrotrophs is mainly based on boosted JA-dependent responses, the pathways regulated by the plant hormones SA- and ABA are also required for successful TISR development

  1. Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis.

    Science.gov (United States)

    Latourte, Augustin; Cherifi, Chahrazad; Maillet, Jérémy; Ea, Hang-Korng; Bouaziz, Wafa; Funck-Brentano, Thomas; Cohen-Solal, Martine; Hay, Eric; Richette, Pascal

    2017-04-01

    To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis (OA). Expression of major catabolic and anabolic factors of cartilage was determined in IL-6-treated mouse chondrocytes and cartilage explants. The anti-IL-6-receptor neutralising antibody MR16-1 was used in the destabilisation of the medial meniscus (DMM) mouse model of OA. Stat3 blockade was investigated by the small molecule Stattic ex vivo and in the DMM model. In chondrocytes and cartilage explants, IL-6 treatment reduced proteoglycan content with increased production of matrix metalloproteinase (MMP-3 and MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4 and ADAMTS-5). IL-6 induced Stat3 and extracellular signal-regulated kinase (ERK) 1/2 signalling but not p38, c-Jun N-terminal kinase or Akt. In the DMM model, Stat3 was activated in cartilage, but neither in the synovium nor in the subchondral bone. Systemic blockade of IL-6 by MR16-1 alleviated DMM-induced OA cartilage lesions, impaired the osteophyte formation and the extent of synovitis. In the same model, Stattic had similar beneficial effects on cartilage and osteophyte formation. Stattic, but not an ERK1/2 inhibitor, significantly counteracted the catabolic effects of IL-6 on cartilage explants and suppressed the IL-6-induced chondrocytes apoptosis. IL-6 induces chondrocyte catabolism mainly via Stat3 signalling, a pathway activated in cartilage from joint subjected to DMM. Systemic blockade of IL-6 or STAT-3 can alleviate DMM-induced OA in mice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  2. Genetic variation of the ghrelin signaling system in females with severe alcohol dependence.

    Science.gov (United States)

    Landgren, Sara; Jerlhag, Elisabet; Hallman, Jarmila; Oreland, Lars; Lissner, Lauren; Strandhagen, Elisabeth; Thelle, Dag S; Zetterberg, Henrik; Blennow, Kaj; Engel, Jörgen A

    2010-09-01

    Central ghrelin signaling is required for the rewarding effects of alcohol in mice. Because ghrelin is implied in other addictive behaviors such as eating disorders and smoking, and because there is co-morbidity between these disorders and alcohol dependence, the ghrelin signaling system could be involved in mediating reward in general. Furthermore, in humans, single nucleotide polymorphisms (SNPs) and haplotypes of the pro-ghrelin gene (GHRL) and the ghrelin receptor gene (GHSR) have previously been associated with increased alcohol consumption and increased body weight. Known gender differences in plasma ghrelin levels prompted us to investigate genetic variation of the ghrelin signaling system in females with severe alcohol dependence (n = 113) and in a selected control sample of female low-consumers of alcohol from a large cohort study in southwest Sweden (n = 212). Six tag SNPs in the GHRL (rs696217, rs3491141, rs4684677, rs35680, rs42451, and rs26802) and four tag SNPs in the GHSR (rs495225, rs2232165, rs572169, and rs2948694) were genotyped in all individuals. We found that one GHRL haplotype was associated with reports of paternal alcohol dependence as well as with reports of withdrawal symptoms in the female alcohol-dependent group. Associations with 2 GHSR haplotypes and smoking were also shown. One of these haplotypes was also negatively associated with BMI in controls, while another haplotype was associated with having the early-onset, more heredity-driven, type 2 form of alcohol dependence in the patient group. Taken together, the genes encoding the ghrelin signaling system cannot be regarded as major susceptibility genes for female alcohol dependence, but is, however, involved in paternal heritability and may affect other reward- and energy-related factors such as smoking and BMI.

  3. Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems

    Science.gov (United States)

    Hook, Vivian; Bandeira, Nuno

    2015-12-01

    Neuropeptides regulate intercellular signaling as neurotransmitters of the central and peripheral nervous systems, and as peptide hormones in the endocrine system. Diverse neuropeptides of distinct primary sequences of various lengths, often with post-translational modifications, coordinate and integrate regulation of physiological functions. Mass spectrometry-based analysis of the diverse neuropeptide structures in neuropeptidomics research is necessary to define the full complement of neuropeptide signaling molecules. Human neuropeptidomics has notable importance in defining normal and dysfunctional neuropeptide signaling in human health and disease. Neuropeptidomics has great potential for expansion in translational research opportunities for defining neuropeptide mechanisms of human diseases, providing novel neuropeptide drug targets for drug discovery, and monitoring neuropeptides as biomarkers of drug responses. In consideration of the high impact of human neuropeptidomics for health, an observed gap in this discipline is the few published articles in human neuropeptidomics compared with, for example, human proteomics and related mass spectrometry disciplines. Focus on human neuropeptidomics will advance new knowledge of the complex neuropeptide signaling networks participating in the fine control of neuroendocrine systems. This commentary review article discusses several human neuropeptidomics accomplishments that illustrate the rapidly expanding diversity of neuropeptides generated by protease processing of pro-neuropeptide precursors occurring within the secretory vesicle proteome. Of particular interest is the finding that human-specific cathepsin V participates in producing enkephalin and likely other neuropeptides, indicating unique proteolytic mechanisms for generating human neuropeptides. The field of human neuropeptidomics has great promise to solve new mechanisms in disease conditions, leading to new drug targets and therapeutic agents for human

  4. A digital-signal-processor-based optical tomographic system for dynamic imaging of joint diseases

    Science.gov (United States)

    Lasker, Joseph M.

    Over the last decade, optical tomography (OT) has emerged as viable biomedical imaging modality. Various imaging systems have been developed that are employed in preclinical as well as clinical studies, mostly targeting breast imaging, brain imaging, and cancer related studies. Of particular interest are so-called dynamic imaging studies where one attempts to image changes in optical properties and/or physiological parameters as they occur during a system perturbation. To successfully perform dynamic imaging studies, great effort is put towards system development that offers increasingly enhanced signal-to-noise performance at ever shorter data acquisition times, thus capturing high fidelity tomographic data within narrower time periods. Towards this goal, I have developed in this thesis a dynamic optical tomography system that is, unlike currently available analog instrumentation, based on digital data acquisition and filtering techniques. At the core of this instrument is a digital signal processor (DSP) that collects, collates, and processes the digitized data set. Complementary protocols between the DSP and a complex programmable logic device synchronizes the sampling process and organizes data flow. Instrument control is implemented through a comprehensive graphical user interface which integrates automated calibration, data acquisition, and signal post-processing. Real-time data is generated at frame rates as high as 140 Hz. An extensive dynamic range (˜190 dB) accommodates a wide scope of measurement geometries and tissue types. Performance analysis demonstrates very low system noise (˜1 pW rms noise equivalent power), excellent signal precision (˜0.04%--0.2%) and long term system stability (˜1% over 40 min). Experiments on tissue phantoms validate spatial and temporal accuracy of the system. As a potential new application of dynamic optical imaging I present the first application of this method to use vascular hemodynamics as a means of characterizing

  5. Data Fusion to Develop a Driver Drowsiness Detection System with Robustness to Signal Loss

    Directory of Open Access Journals (Sweden)

    Sajjad Samiee

    2014-09-01

    Full Text Available This study proposes a drowsiness detection approach based on the combination of several different detection methods, with robustness to the input signal loss. Hence, if one of the methods fails for any reason, the whole system continues to work properly. To choose correct combination of the available methods and to utilize the benefits of methods of different categories, an image processing-based technique as well as a method based on driver-vehicle interaction is used. In order to avoid driving distraction, any use of an intrusive method is prevented. A driving simulator is used to gather real data and then artificial neural networks are used in the structure of the designed system. Several tests were conducted on twelve volunteers while their sleeping situations during one day prior to the tests, were fully under control. Although the impact of the proposed system on the improvement of the detection accuracy is not remarkable, the results indicate the main advantages of the system are the reliability of the detections and robustness to the loss of the input signals. The high reliability of the drowsiness detection systems plays an important role to reduce drowsiness related road accidents and their associated costs.

  6. A Weibull Approach for Enabling Safety-Oriented Decision-Making for Electronic Railway Signaling Systems

    Directory of Open Access Journals (Sweden)

    Emanuele Pascale

    2018-04-01

    Full Text Available This paper presents the advantages of using Weibull distributions, within the context of railway signaling systems, for enabling safety-oriented decision-making. Failure rates are used to statistically model the basic event of fault-tree analysis, and their value sizes the maximum allowable latency of failures to fulfill the safety target for which the system has been designed. Relying on field-return failure data, Weibull parameters have been calculated for an existing electronic signaling system and a comparison with existing predictive reliability data, based on exponential distribution, is provided. Results are discussed in order to drive considerations on the respect of quantitative targets and on the impact that a wrong hypothesis might have on the choice of a given architecture. Despite the huge amount of information gathered through the after-sales logbook used to build reliability distribution, several key elements for reliable estimation of failure rate values are still missing. This might affect the uncertainty of reliability parameters and the effort required to collect all the information. We then present how to intervene when operational failure rates present higher values compared to the theoretical approach: increasing the redundancies of the system or performing preventive maintenance tasks. Possible consequences of unjustified adoption of constant failure rate are presented. Some recommendations are also shared in order to build reliability-oriented logbooks and avoid data censoring phenomena by enhancing the functions of the electronic boards composing the system.

  7. EEG Signal Quality of a Subcutaneous Recording System Compared to Standard Surface Electrodes

    Directory of Open Access Journals (Sweden)

    Jonas Duun-Henriksen

    2015-01-01

    Full Text Available Purpose. We provide a comprehensive verification of a new subcutaneous EEG recording device which promises robust and unobtrusive measurements over ultra-long time periods. The approach is evaluated against a state-of-the-art surface EEG electrode technology. Materials and Methods. An electrode powered by an inductive link was subcutaneously implanted on five subjects. Surface electrodes were placed at sites corresponding to the subcutaneous electrodes, and the EEG signals were evaluated with both quantitative (power spectral density and coherence analysis and qualitative (blinded subjective scoring by neurophysiologists analysis. Results. The power spectral density and coherence analysis were very similar during measurements of resting EEG. The scoring by neurophysiologists showed a higher EEG quality for the implanted system for different subject states (eyes open and eyes closed. This was most likely due to higher amplitude of the subcutaneous signals. During periods with artifacts, such as chewing, blinking, and eye movement, the two systems performed equally well. Conclusions. Subcutaneous measurements of EEG with the test device showed high quality as measured by both quantitative and more subjective qualitative methods. The signal might be superior to surface EEG in some aspects and provides a method of ultra-long term EEG recording in situations where this is required and where a small number of EEG electrodes are sufficient.

  8. Method and system of measuring ultrasonic signals in the plane of a moving web

    Science.gov (United States)

    Hall, Maclin S.; Jackson, Theodore G.; Wink, Wilmer A.; Knerr, Christopher

    1996-01-01

    An improved system for measuring the velocity of ultrasonic signals within the plane of moving web-like materials, such as paper, paperboard and the like. In addition to velocity measurements of ultrasonic signals in the plane of the web in the machine direction, MD, and a cross direction, CD, generally perpendicular to the direction of the traveling web, therefor, one embodiment of the system in accordance with the present invention is also adapted to provide on-line indication of the polar specific stiffness of the moving web. In another embodiment of the invention, the velocity of ultrasonic signals in the plane of the web are measured by way of a plurality of ultrasonic transducers carried by synchronously driven wheels or cylinders, thus eliminating undue transducer wear due to any speed differences between the transducers and the web. In order to provide relatively constant contact force between the transducers and the webs, the transducers are mounted in a sensor housings which include a spring for biasing the transducer radially outwardly. The sensor housings are adapted to be easily and conveniently mounted to the carrier to provide a relatively constant contact force between the transducers and the moving web.

  9. Method and apparatus for signal processing in a sensor system for use in spectroscopy

    Science.gov (United States)

    O'Connor, Paul [Bellport, NY; DeGeronimo, Gianluigi [Nesconset, NY; Grosholz, Joseph [Natrona Heights, PA

    2008-05-27

    A method for processing pulses arriving randomly in time on at least one channel using multiple peak detectors includes asynchronously selecting a non-busy peak detector (PD) in response to a pulse-generated trigger signal, connecting the channel to the selected PD in response to the trigger signal, and detecting a pulse peak amplitude. Amplitude and time of arrival data are output in first-in first-out (FIFO) sequence. An apparatus includes trigger comparators to generate the trigger signal for the pulse-receiving channel, PDs, a switch for connecting the channel to the selected PD, and logic circuitry which maintains the write pointer. Also included, time-to-amplitude converters (TACs) convert time of arrival to analog voltage and an analog multiplexer provides FIFO output. A multi-element sensor system for spectroscopy includes detector elements, channels, trigger comparators, PDs, a switch, and a logic circuit with asynchronous write pointer. The system includes TACs, a multiplexer and analog-to-digital converter.

  10. Classification of acoustic emission signals for drive systems coupling crack detection in semi-real time

    International Nuclear Information System (INIS)

    Godinez, V.; Shu, F.; Finlayson, R.; O'Donnell, B.; Anastasopoulos, A.; Tsimogiannis, A.

    2004-01-01

    Early detection of mechanical failure in helicopter drive train components is a key safety and economical issue with both military and civil sectors of aviation. Of these components, couplings are particularly critical. The objective of this work is to demonstrate the feasibility of designing and developing a reliable, real time monitoring methodology based on Supervised Pattern Recognition (SPR) for early detection of cracks in couplings used in helicopter and engine drive systems. Within this framework, a portable Acoustic Emission (AE) system was used, equipped with a semi-real time SPR software package. Results from AE tests performed in a gearbox-testing bench at different speeds and different torque values are presented. These results indicate that the energy content of different frequency bands in the AE signals power spectra is strongly correlated with the introduction of EDM notches in the main gear. Further tests indicate that a strong shift in the frequency of the AE signals is observed after spalling occurred in the pinion gear. The variation of displacement and velocity between signal classes are discussed as a potential feature in characterizing crack severity. Finally, a scope of the work for optimizing the methodology in detecting and evaluating coupling cracking in real time will be presented. (author)

  11. Sharing the Licensed Spectrum of Full-Duplex Systems using Improper Gaussian Signaling

    KAUST Repository

    Gaafar, Mohamed; Amin, Osama; Abediseid, Walid; Alouini, Mohamed-Slim

    2016-01-01

    Sharing the spectrum with in-band full-duplex (FD) primary users (PU) is a challenging and interesting problem in the underlay cognitive radio (CR) systems. The self-inteference introducsed at the primary network may dramatically impede the secondary user (SU) opportunity to access the spectrum. In this work, we attempt to tackle this problem through the use of so called improper Gaussian signaling (IGS). Such a signaling technique has demonstrated its superiority in improving the overall performance in interference limited networks. Particularly, we assume a system with a SU pair working in half-duplex mode that uses IGS while the FD PU pair implements the regular proper Gaussiam signaling techniques. Frist, we derive a closed form expression for the SU outage probability while maintaining the required PU quality-of-service based on the average channel state information. Finally, we provide some numerical results that validate the tightness of the PU outage probability bound and demonstrate the advantage of employing IGS to the SU in order to access the spectrum of the FD PU.

  12. Sharing the Licensed Spectrum of Full-Duplex Systems using Improper Gaussian Signaling

    KAUST Repository

    Gaafar, Mohamed

    2016-01-06

    Sharing the spectrum with in-band full-duplex (FD) primary users (PU) is a challenging and interesting problem in the underlay cognitive radio (CR) systems. The self-inteference introducsed at the primary network may dramatically impede the secondary user (SU) opportunity to access the spectrum. In this work, we attempt to tackle this problem through the use of so called improper Gaussian signaling (IGS). Such a signaling technique has demonstrated its superiority in improving the overall performance in interference limited networks. Particularly, we assume a system with a SU pair working in half-duplex mode that uses IGS while the FD PU pair implements the regular proper Gaussiam signaling techniques. Frist, we derive a closed form expression for the SU outage probability while maintaining the required PU quality-of-service based on the average channel state information. Finally, we provide some numerical results that validate the tightness of the PU outage probability bound and demonstrate the advantage of employing IGS to the SU in order to access the spectrum of the FD PU.

  13. Multifragmentation of heavy systems: partitions and phase transition signals; Multifragmentation de systemes lourds: partitions et signaux de transition de phases

    Energy Technology Data Exchange (ETDEWEB)

    Bonnet, E

    2006-09-15

    This work studies mononuclear systems produced in heavy ion collisions with large (peripheral: Au+Au) and small (central: Xe+Sn et Gd+U) impact parameters. These two classes of collisions need specific selections in order to isolate sources in thermal equilibrium (quasi-projectiles and quasi-fusion sources). We perform analyses on the statistical ensembles of events obtained after those selections to evidence phase transition signatures. First, a bimodal behaviour of the biggest fragment (Z{sub 1}) distribution, in peripheral collisions, is related to an order parameter using a renormalisation with an equiprobable excitation energy (E{sup *}) distribution constraint. A comparison with a canonical ensemble gives us information on the coexistence region location. Then, we compare static and dynamical properties of fragments produced by these sources in peripheral and central collisions. Differences on fragment multiplicities and charge asymmetry of partitions are observed. They find their origins in the presence or not of a velocity field mostly related to collective radial expansion during fragment formation. Analyses of the signal related to abnormal fluctuations of configurational energies and of the fossil signal related to spinodal decomposition for Au quasi-projectiles are performed to establish a link with the same signals already observed for central collisions. Finally, the location of events of the two types of sources in the E{sup *} - Z{sub 1} plane, are compared with a phase diagram, particularly the boundaries of the coexistence region deduced from the previous signals. (author)

  14. Increase of nonlinear signal distortions due to linear mode coupling in space division multiplexed systems

    DEFF Research Database (Denmark)

    Kutluyarov, Ruslan V.; Bagmanov, Valeriy Kh; Antonov, Vyacheslav V.

    2017-01-01

    This paper is focused on the analysis of linear and nonlinear mode coupling in space division multiplexed (SDM) optical communications over step-index fiber in few-mode regime. Linear mode coupling is caused by the fiber imperfections, while the nonlinear coupling is caused by the Kerr......-nonlinearities. Therefore, we use the system of generalized coupled nonlinear Schrödinger equations (GCNLSE) to describe the signal propagation. We analytically show that the presence of linear mode coupling may cause increasing of the nonlinear signal distortions. For the detailed study we solve GCNLSE numerically...... for the standard step index fiber at the wavelength of 850 nm in the basis of spatial modes with helical phase front (vortex modes) and for a special kind of few-mode fiber with enlarged core, providing propagation of five spatial modes at 1550 nm. Simulation results confirm that the linear mode coupling may lead...

  15. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.

    Science.gov (United States)

    Liu, Qiang; Zhang, Juan; Zerbinatti, Celina; Zhan, Yan; Kolber, Benedict J; Herz, Joachim; Muglia, Louis J; Bu, Guojun

    2011-01-11

    Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Together, our results demonstrate that the lipoprotein receptor LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in the adult central nervous system.

  16. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.

    Directory of Open Access Journals (Sweden)

    Qiang Liu

    2011-01-01

    Full Text Available Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Together, our results demonstrate that the lipoprotein receptor LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in the adult central nervous system.

  17. Phasor Measurement Unit Test and Applications for Small Signal Stability Assessment and Improvement of Power System

    DEFF Research Database (Denmark)

    Ghiga, Radu

    to be less predictable. Therefore, the methods used for stability and security assessment will most likely use information from the wide-area measurements systems (WAMS). The work presented in this thesis deals on one hand with the development of test methods and validation of phasor measurement units (PMUs......) which are considered to be one of the key technologies in WAMS, and on the other hand with the possibility of using PMU measurements together with large wind power plants (WPPs) to help improve the damping of inter area oscillations. To validate the PMUs, a laboratory test setup is assembled....... The hardware components are capable of generating, with the required accuracy, the test signals injected in the PMUs. The signals are created according to the requirements defined in the current IEEE C37.118.1-2011 standard, to test the steady-state and dynamic compliance of the PMUs. The performance...

  18. New detection system and signal processing for the tokamak ISTTOK heavy ion beam diagnostic

    International Nuclear Information System (INIS)

    Henriques, R. B.; Nedzelskiy, I. S.; Malaquias, A.; Fernandes, H.

    2012-01-01

    The tokamak ISTTOK heavy ion beam diagnostic (HIBD) operates with a multiple cell array detector (MCAD) that allows for the plasma density and the plasma density fluctuations measurements simultaneously at different sampling volumes across the plasma. To improve the capability of the plasma density fluctuations investigations, a new detection system and new signal conditioning amplifier have been designed and tested. The improvements in MCAD design are presented which allow for nearly complete suppression of the spurious plasma background signal by applying a biasing potential onto special electrodes incorporated into MCAD. The new low cost and small size transimpedance amplifiers are described with the parameters of 400 kHz, 10 7 V/A, 0.4 nA of RMS noise, adequate for the plasma density fluctuations measurements.

  19. New detection system and signal processing for the tokamak ISTTOK heavy ion beam diagnostic.

    Science.gov (United States)

    Henriques, R B; Nedzelskiy, I S; Malaquias, A; Fernandes, H

    2012-10-01

    The tokamak ISTTOK havy ion beam diagnostic (HIBD) operates with a multiple cell array detector (MCAD) that allows for the plasma density and the plasma density fluctuations measurements simultaneously at different sampling volumes across the plasma. To improve the capability of the plasma density fluctuations investigations, a new detection system and new signal conditioning amplifier have been designed and tested. The improvements in MCAD design are presented which allow for nearly complete suppression of the spurious plasma background signal by applying a biasing potential onto special electrodes incorporated into MCAD. The new low cost and small size transimpedance amplifiers are described with the parameters of 400 kHz, 10(7) V/A, 0.4 nA of RMS noise, adequate for the plasma density fluctuations measurements.

  20. New detection system and signal processing for the tokamak ISTTOK heavy ion beam diagnostic

    Energy Technology Data Exchange (ETDEWEB)

    Henriques, R. B.; Nedzelskiy, I. S.; Malaquias, A.; Fernandes, H. [Associacao Euratom/IST, Instituto de Plasmas e Fusao Nuclear, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, 1049-001 Lisboa (Portugal)

    2012-10-15

    The tokamak ISTTOK heavy ion beam diagnostic (HIBD) operates with a multiple cell array detector (MCAD) that allows for the plasma density and the plasma density fluctuations measurements simultaneously at different sampling volumes across the plasma. To improve the capability of the plasma density fluctuations investigations, a new detection system and new signal conditioning amplifier have been designed and tested. The improvements in MCAD design are presented which allow for nearly complete suppression of the spurious plasma background signal by applying a biasing potential onto special electrodes incorporated into MCAD. The new low cost and small size transimpedance amplifiers are described with the parameters of 400 kHz, 10{sup 7} V/A, 0.4 nA of RMS noise, adequate for the plasma density fluctuations measurements.

  1. Extracellular vesicles mediate signaling between the aqueous humor producing and draining cells in the ocular system.

    Science.gov (United States)

    Lerner, Natalie; Avissar, Sofia; Beit-Yannai, Elie

    2017-01-01

    Canonical Wnt signaling is associated with glaucoma pathogenesis and intraocular pressure (IOP) regulation. Our goal was to gain insight into the influence of non-pigmented ciliary epithelium (NPCE)-derived exosomes on Wnt signaling by trabecular meshwork (TM) cells. The potential impact of exosomes on Wnt signaling in the ocular drainage system remains poorly understood. Exosomes isolated from media collected from cultured NPCE cells by differential ultracentrifugation were characterized by dynamic light scattering (DLS), tunable resistive pulse sensing (TRPS), and nanoparticle tracking analysis (NTA), sucrose density gradient migration and transmission electron microscopy (TEM). The cellular target specificity of the NPCE-derived exosomes was investigated by confocal microscopy-based monitoring of the uptake of DiD-labeled exosomes over time, as compared to uptake by various cell lines. Changes in Wnt protein levels in TM cells induced by NPCE exosomes were evaluated by Western blot. Exosomes derived from NPCE cells were purified and detected as small rounded 50-140 nm membrane vesicles, as defined by DLS, NTA, TRPS and TEM. Western blot analysis indicated that the nanovesicles were positive for classic exosome markers, including Tsg101 and Alix. Isolated nanoparticles were found in sucrose density fractions typical of exosomes (1.118-1.188 g/mL sucrose). Using confocal microscopy, we demonstrated time-dependent specific accumulation of the NPCE-derived exosomes in NTM cells. Other cell lines investigated hardly revealed any exosome uptake. We further showed that exosomes induced changes in Wnt signaling protein expression in the TM cells. Western blot analysis further revealed decreased phosphorylation of GKS3β and reduced β-catenin levels. Finally, we found that treatment of NTM cells with exosomes resulted in a greater than 2-fold decrease in the level of β-catenin in the cytosolic fraction. In contrast, no remarkable difference in the amount of

  2. I. Advances in NMR Signal Processing. II. Spin Dynamics in Quantum Dissipative Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Yung-Ya [Univ. of California, Berkeley, CA (United States)

    1998-11-01

    Part I. Advances in IVMR Signal Processing. Improvements of sensitivity and resolution are two major objects in the development of NMR/MRI. A signal enhancement method is first presented which recovers signal from noise by a judicious combination of a priordmowledge to define the desired feasible solutions and a set theoretic estimation for restoring signal properties that have been lost due to noise contamination. The effect of noise can be significantly mitigated through the process of iteratively modifying the noisy data set to the smallest degree necessary so that it possesses a collection of prescribed properties and also lies closest to the original data set. A novel detection-estimation scheme is then introduced to analyze noisy and/or strongly damped or truncated FIDs. Based on exponential modeling, the number of signals is detected based on information estimated using the matrix pencil method. theory and the spectral parameters are Part II. Spin Dynamics in body dipole-coupled systems Quantum Dissipative Systems. Spin dynamics in manyconstitutes one of the most fundamental problems in magnetic resonance and condensed-matter physics. Its many-spin nature precludes any rigorous treatment. ‘Therefore, the spin-boson model is adopted to describe in the rotating frame the influence of the dipolar local fields on a tagged spin. Based on the polaronic transform and a perturbation treatment, an analytical solution is derived, suggesting the existence of self-trapped states in the. strong coupling limit, i.e., when transverse local field >> longitudinal local field. Such nonlinear phenomena originate from the joint action of the lattice fluctuations and the reaction field. Under semiclassical approximation, it is found that the main effect of the reaction field is the renormalization of the Hamiltonian of interest. Its direct consequence is the two-step relaxation process: the spin is initially localized in a quasiequilibrium state, which is later detrapped by

  3. Optical signal demultiplexing and conversion in the fullerene–oligothiophene–CdS system

    Energy Technology Data Exchange (ETDEWEB)

    Lewandowska, Kornelia [Polish Academy of Science, Institute of Molecular Physics, ul. Smoluchowskiego 17, 60-179 Poznań (Poland); Podborska, Agnieszka; Kwolek, Przemysław [AGH University of Science and Technology, Faculty of Non-Ferrous Metals, al. A. Mickiewicza 30, 30-059 Kraków (Poland); Kim, Tae-Dong; Lee, Kwang-Sup [Department of Advanced Materials, Hannam University, Daejeon 305-811 (Korea, Republic of); Szaciłowski, Konrad, E-mail: szacilow@agh.edu.pl [AGH University of Science and Technology, Faculty of Non-Ferrous Metals, al. A. Mickiewicza 30, 30-059 Kraków (Poland); Jagiellonian University, Faculty of Chemistry, ul. R. Ingardena 3, 30-60 Kraków (Poland)

    2014-11-15

    Graphical abstract: - Highlights: • Photoelectrochemical photocurrent switching (PEPS) effect in the C{sub 60} derivatives system. • Systems for optical-to-electrical signal conversion. • Fullerene–oligothiophene dyad system as 1:2-demultiplexer. - Abstract: We report the photoelectrochemical photocurrent switching (PEPS) effect in the system based on a C{sub 60} derivatives and nanostructured cadmium sulfide. Rapid and efficient photocurrent switching upon changes of the electrode potential was observed. This process relies on the photocurrent generation by semiconducting particles and interfacial electron transfer reactions governed by the redox chemistry of fullerene derivatives (fullerene–oligothiophene dyads) with molecular oxygen as a final electron acceptor. Surprisingly, fullerene derivatives without thiophene moieties were much less efficient as CdS modifiers. These peculiar photoelectrochemical properties were applied for construction of an optoelectronic logic device.

  4. A Novel Blind Source Separation Algorithm and Performance Analysis of Weak Signal against Strong Interference in Passive Radar Systems

    Directory of Open Access Journals (Sweden)

    Chengjie Li

    2016-01-01

    Full Text Available In Passive Radar System, obtaining the mixed weak object signal against the super power signal (jamming is still a challenging task. In this paper, a novel framework based on Passive Radar System is designed for weak object signal separation. Firstly, we propose an Interference Cancellation algorithm (IC-algorithm to extract the mixed weak object signals from the strong jamming. Then, an improved FastICA algorithm with K-means cluster is designed to separate each weak signal from the mixed weak object signals. At last, we discuss the performance of the proposed method and verify the novel method based on several simulations. The experimental results demonstrate the effectiveness of the proposed method.

  5. Transient signals on transmission lines an introduction to non-ideal effects and signal integrity issues in electrical systems

    CERN Document Server

    Peterson, Andrew

    2009-01-01

    This lecture provides an introduction to transmission line effects in the time domain. Fundamentals including time of flight, impedance discontinuities, proper termination schemes, nonlinear and reactive loads, and crosstalk are considered. Required prerequisite knowledge is limited to conventional circuit theory. The material is intended to supplement standard textbooks for use with undergraduate students in electrical engineering or computer engineering. The contents should also be of value to practicing engineers with interests in signal integrity and high-speed digital design.Table of Cont

  6. Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways.

    Science.gov (United States)

    Zdanowski, Robert; Krzyżowska, Małgorzata; Ujazdowska, Dominika; Lewicka, Aneta; Lewicki, Sławomir

    2015-01-01

    Acetylcholine has been well known as one of the most exemplary neurotransmitters. In humans, this versatile molecule and its synthesizing enzyme, choline acetyltransferase, have been found in various non-neural tissues such as the epithelium, endothelium, mesothelium muscle, blood cells and immune cells. The non-neuronal acetylcholine is accompanied by the expression of acetylcholinesterase and nicotinic/muscarinic acetylcholine receptors. Increasing evidence of the non-neuronal acetylcholine system found throughout the last few years has indicated this neurotransmitter as one of the major cellular signaling molecules (associated e.g. with kinases and transcription factors activity). This system is responsible for maintenance and optimization of the cellular function, such as proliferation, differentiation, adhesion, migration, intercellular contact and apoptosis. Additionally, it controls proper activity of immune cells and affects differentiation, antigen presentation or cytokine production (both pro- and anti-inflammatory). The present article reviews recent findings about the non-neuronal cholinergic system in the field of immune system and intracellular signaling pathways.

  7. Development of Hand Grip Assistive Device Control System for Old People through Electromyography (EMG Signal Acquisitions

    Directory of Open Access Journals (Sweden)

    Khamis Herman

    2017-01-01

    Full Text Available The hand grip assistive device is a glove to assist old people who suffer from hand weakness in their daily life activities. The device earlier control system only use simple on and off switch. This required old people to use both hand to activate the device. The new control system of the hand grip assistive device was developed to allow single hand operation for old people. New control system take advantages of electromyography (EMG and flex sensor which was implemented to the device. It was programmed into active and semi-active mode operation. EMG sensors were placed on the forearm to capture EMG signal of Flexor Digitorum Profundus muscle to activate the device. Flex sensor was used to indicate the finger position and placed on top of the finger. The signal from both sensors then used to control the device. The new control system allowed single hand operation and designed to prevent user from over depended on the device by activating it through moving their fingers.

  8. Information theory and signal transduction systems: from molecular information processing to network inference.

    Science.gov (United States)

    Mc Mahon, Siobhan S; Sim, Aaron; Filippi, Sarah; Johnson, Robert; Liepe, Juliane; Smith, Dominic; Stumpf, Michael P H

    2014-11-01

    Sensing and responding to the environment are two essential functions that all biological organisms need to master for survival and successful reproduction. Developmental processes are marshalled by a diverse set of signalling and control systems, ranging from systems with simple chemical inputs and outputs to complex molecular and cellular networks with non-linear dynamics. Information theory provides a powerful and convenient framework in which such systems can be studied; but it also provides the means to reconstruct the structure and dynamics of molecular interaction networks underlying physiological and developmental processes. Here we supply a brief description of its basic concepts and introduce some useful tools for systems and developmental biologists. Along with a brief but thorough theoretical primer, we demonstrate the wide applicability and biological application-specific nuances by way of different illustrative vignettes. In particular, we focus on the characterisation of biological information processing efficiency, examining cell-fate decision making processes, gene regulatory network reconstruction, and efficient signal transduction experimental design. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Early Life Experience and Gut Microbiome: The Brain-Gut-Microbiota Signaling System.

    Science.gov (United States)

    Cong, Xiaomei; Henderson, Wendy A; Graf, Joerg; McGrath, Jacqueline M

    2015-10-01

    Over the past decades, advances in neonatal care have led to substantial increases in survival among preterm infants. With these gains, recent concerns have focused on increases in neurodevelopment morbidity related to the interplay between stressful early life experiences and the immature neuroimmune systems. This interplay between these complex mechanisms is often described as the brain-gut signaling system. The role of the gut microbiome and the brain-gut signaling system have been found to be remarkably related to both short- and long-term stress and health. Recent evidence supports that microbial species, ligands, and/or products within the developing intestine play a key role in early programming of the central nervous system and regulation of the intestinal innate immunity. The purpose of this state-of-the-science review is to explore the supporting evidence demonstrating the importance of the brain-gut-microbiota axis in regulation of early life experience. We also discuss the role of gut microbiome in modulating stress and pain responses in high-risk infants. A conceptual framework has been developed to illustrate the regulation mechanisms involved in early life experience. The science in this area is just beginning to be uncovered; having a fundamental understanding of these relationships will be important as new discoveries continue to change our thinking, leading potentially to changes in practice and targeted interventions.

  10. A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes.

    Directory of Open Access Journals (Sweden)

    Vladimir E Bondarenko

    Full Text Available The β1-adrenergic signaling system plays an important role in the functioning of cardiac cells. Experimental data shows that the activation of this system produces inotropy, lusitropy, and chronotropy in the heart, such as increased magnitude and relaxation rates of [Ca(2+]i transients and contraction force, and increased heart rhythm. However, excessive stimulation of β1-adrenergic receptors leads to heart dysfunction and heart failure. In this paper, a comprehensive, experimentally based mathematical model of the β1-adrenergic signaling system for mouse ventricular myocytes is developed, which includes major subcellular functional compartments (caveolae, extracaveolae, and cytosol. The model describes biochemical reactions that occur during stimulation of β1-adrenoceptors, changes in ionic currents, and modifications of Ca(2+ handling system. Simulations describe the dynamics of major signaling molecules, such as cyclic AMP and protein kinase A, in different subcellular compartments; the effects of inhibition of phosphodiesterases on cAMP production; kinetics and magnitudes of phosphorylation of ion channels, transporters, and Ca(2+ handling proteins; modifications of action potential shape and duration; magnitudes and relaxation rates of [Ca(2+]i transients; changes in intracellular and transmembrane Ca(2+ fluxes; and [Na(+]i fluxes and dynamics. The model elucidates complex interactions of ionic currents upon activation of β1-adrenoceptors at different stimulation frequencies, which ultimately lead to a relatively modest increase in action potential duration and significant increase in [Ca(2+]i transients. In particular, the model includes two subpopulations of the L-type Ca(2+ channels, in caveolae and extracaveolae compartments, and their effects on the action potential and [Ca(2+]i transients are investigated. The presented model can be used by researchers for the interpretation of experimental data and for the developments of

  11. An Internet of Things based physiological signal monitoring and receiving system for virtual enhanced health care network.

    Science.gov (United States)

    Rajan, J Pandia; Rajan, S Edward

    2018-01-01

    Wireless physiological signal monitoring system designing with secured data communication in the health care system is an important and dynamic process. We propose a signal monitoring system using NI myRIO connected with the wireless body sensor network through multi-channel signal acquisition method. Based on the server side validation of the signal, the data connected to the local server is updated in the cloud. The Internet of Things (IoT) architecture is used to get the mobility and fast access of patient data to healthcare service providers. This research work proposes a novel architecture for wireless physiological signal monitoring system using ubiquitous healthcare services by virtual Internet of Things. We showed an improvement in method of access and real time dynamic monitoring of physiological signal of this remote monitoring system using virtual Internet of thing approach. This remote monitoring and access system is evaluated in conventional value. This proposed system is envisioned to modern smart health care system by high utility and user friendly in clinical applications. We claim that the proposed scheme significantly improves the accuracy of the remote monitoring system compared to the other wireless communication methods in clinical system.

  12. System identification by methods from the statistical signal theory, history and state of the art

    International Nuclear Information System (INIS)

    Christensen, Palle; Gundersen, Vidar B.

    1999-01-01

    Condition monitoring is an important area in which the OECD Halden Reactor Project has developed several tools. This paper presents a general overview of methods utilised in diagnosis systems, signal validation systems and process optimisation systems such as EFD, Mocom, Aladdin and PEANO. An overview of lessons learned on diagnosis of technical systems with special reference to system identification is reported. The analysis of input-output behaviour by special, suitable methods may be used as a tool for diagnosis. An overview of methods for empirical modelling and data analysis and their major differences is presented. It is explained how system identification methods and transforms may be used to build models based on observed data from a system. According to the Webster dictionary diagnosis is 'Investigation or analysis of the cause or nature of a condition, situation or a problem.' By examining data collected from a process the aim is to detect abnormal conditions and if possible understand what has been the cause of the observed problem. Section 1 gives a retrospective view at the development in the field of system identification. Section 2 presents a classification of the methods, while section 3 provides some practical advice on how diagnosis can be carried out by means of system identification methods (author) (ml)

  13. System performance enhancement with pre-distorted OOFDM signal waveforms in DM/DD systems.

    Science.gov (United States)

    Sánchez, C; Ortega, B; Capmany, J

    2014-03-24

    In this work we propose a pre-distortion technique for the mitigation of the nonlinear distortion present in directly modulated/detected OOFDM systems and explore the system performance achieved under varying system parameters. Simulation results show that the proposed pre-distortion technique efficiently mitigates the nonlinear distortion, achieving transmission information rates around 40 Gbits/s and 18.5 Gbits/s over 40 km and 100 km of single mode fiber links, respectively, under optimum operating conditions. Moreover, the proposed pre-distortion technique can potentially provide higher system performance to that obtained with nonlinear equalization at the receiver.

  14. Automatic Clock and Time Signal System of the Astronomical Agency in East Asia Area

    Science.gov (United States)

    Lee, Yong Sam

    2009-09-01

    We analysed the old automatic clock and time signal system that was used by the national astronomical agency in East Asian Area. Jagyeongnu is a kind of water clock that was operated by the flowing water in Joseon Dynasty. Seowoongwan managed the water clock so as to keep the standard time system in the dynasty from the 16th year (1434) of King Sejong's reign. In 1438 the Okru that was invented in the period. Such kind of clock system already was used in China, which was Shui yun i hsiang t'ai (?) in 1092. During the period Joseon Dynasty, China and Japan had been kept the time system that one day is divided into 12 shin (?2?) or 100 gak (?). However detailed part of the system had a little difference among the three countries. Though the whole system of water clock in Joseon had manufactured on the basis of Chinese, it had been gradually developed by own method and idea. In this study we show the historical records of the standard time keeping system in East Asian history. And then we can inform materials on the structure and functional devises for the purpose of new restoration models about the automatic clock and time system.

  15. Network-based Type-2 Fuzzy System with Water Flow Like Algorithm for System Identification and Signal Processing

    Directory of Open Access Journals (Sweden)

    Che-Ting Kuo

    2015-02-01

    Full Text Available This paper introduces a network-based interval type-2 fuzzy inference system (NT2FIS with a dynamic solution agent algorithm water flow like algorithm (WFA, for nonlinear system identification and blind source separation (BSS problem. The NT2FIS consists of interval type-2 asymmetric fuzzy membership functions and TSK-type consequent parts to enhance the performance. The proposed scheme is optimized by a new heuristic learning algorithm, WFA, with dynamic solution agents. The proposed WFA is inspired by the natural behavior of water flow. Splitting, moving, merging, evaporation, and precipitation have all been introduced for optimization. Some modifications, including new moving strategies, such as the application of tabu searching and gradient-descent techniques, are proposed to enhance the performance of the WFA in training the NT2FIS systems. Simulation and comparison results for nonlinear system identification and blind signal separation are presented to illustrate the performance and effectiveness of the proposed approach.

  16. Monitoring super-volcanoes: geophysical and geochemical signals at Yellowstone and other large caldera systems.

    Science.gov (United States)

    Lowenstern, Jacob B; Smith, Robert B; Hill, David P

    2006-08-15

    Earth's largest calderas form as the ground collapses during immense volcanic eruptions, when hundreds to thousands of cubic kilometres of magma are explosively withdrawn from the Earth's crust over a period of days to weeks. Continuing long after such great eruptions, the resulting calderas often exhibit pronounced unrest, with frequent earthquakes, alternating uplift and subsidence of the ground, and considerable heat and mass flux. Because many active and extinct calderas show evidence for repetition of large eruptions, such systems demand detailed scientific study and monitoring. Two calderas in North America, Yellowstone (Wyoming) and Long Valley (California), are in areas of youthful tectonic complexity. Scientists strive to understand the signals generated when tectonic, volcanic and hydrothermal (hot ground water) processes intersect. One obstacle to accurate forecasting of large volcanic events is humanity's lack of familiarity with the signals leading up to the largest class of volcanic eruptions. Accordingly, it may be difficult to recognize the difference between smaller and larger eruptions. To prepare ourselves and society, scientists must scrutinize a spectrum of volcanic signals and assess the many factors contributing to unrest and toward diverse modes of eruption.

  17. Design and Evaluation of Novel Textile Wearable Systems for the Surveillance of Vital Signals

    Directory of Open Access Journals (Sweden)

    Isabel G. Trindade

    2016-09-01

    Full Text Available This article addresses the design, development, and evaluation of T-shirt prototypes that embed novel textile sensors for the capture of cardio and respiratory signals. The sensors are connected through textile interconnects to either an embedded custom-designed data acquisition and transmission unit or to snap fastener terminals for connection to external monitoring devices. The performance of the T-shirt prototype is evaluated in terms of signal-to-noise ratio amplitude and signal interference caused by baseline wander and motion artefacts, through laboratory tests with subjects in standing and walking conditions. Performance tests were also conducted in a hospital environment using a T-shirt prototype connected to a commercial three-channel Holter monitoring device. The textile sensors and interconnects were realized with the assistance of an industrial six-needle digital embroidery tool and their resistance to wear addressed with normalized tests of laundering and abrasion. The performance of these wearable systems is discussed, and pathways and methods for their optimization are highlighted.

  18. Design and Evaluation of Novel Textile Wearable Systems for the Surveillance of Vital Signals.

    Science.gov (United States)

    Trindade, Isabel G; Machado da Silva, José; Miguel, Rui; Pereira, Madalena; Lucas, José; Oliveira, Luís; Valentim, Bruno; Barreto, Jorge; Santos Silva, Manuel

    2016-09-24

    This article addresses the design, development, and evaluation of T-shirt prototypes that embed novel textile sensors for the capture of cardio and respiratory signals. The sensors are connected through textile interconnects to either an embedded custom-designed data acquisition and transmission unit or to snap fastener terminals for connection to external monitoring devices. The performance of the T-shirt prototype is evaluated in terms of signal-to-noise ratio amplitude and signal interference caused by baseline wander and motion artefacts, through laboratory tests with subjects in standing and walking conditions. Performance tests were also conducted in a hospital environment using a T-shirt prototype connected to a commercial three-channel Holter monitoring device. The textile sensors and interconnects were realized with the assistance of an industrial six-needle digital embroidery tool and their resistance to wear addressed with normalized tests of laundering and abrasion. The performance of these wearable systems is discussed, and pathways and methods for their optimization are highlighted.

  19. Towards a Continuous Biometric System Based on ECG Signals Acquired on the Steering Wheel

    Directory of Open Access Journals (Sweden)

    João Ribeiro Pinto

    2017-09-01

    Full Text Available Electrocardiogram signals acquired through a steering wheel could be the key to seamless, highly comfortable, and continuous human recognition in driving settings. This paper focuses on the enhancement of the unprecedented lesser quality of such signals, through the combination of Savitzky-Golay and moving average filters, followed by outlier detection and removal based on normalised cross-correlation and clustering, which was able to render ensemble heartbeats of significantly higher quality. Discrete Cosine Transform (DCT and Haar transform features were extracted and fed to decision methods based on Support Vector Machines (SVM, k-Nearest Neighbours (kNN, Multilayer Perceptrons (MLP, and Gaussian Mixture Models - Universal Background Models (GMM-UBM classifiers, for both identification and authentication tasks. Additional techniques of user-tuned authentication and past score weighting were also studied. The method’s performance was comparable to some of the best recent state-of-the-art methods (94.9% identification rate (IDR and 2.66% authentication equal error rate (EER, despite lesser results with scarce train data (70.9% IDR and 11.8% EER. It was concluded that the method was suitable for biometric recognition with driving electrocardiogram signals, and could, with future developments, be used on a continuous system in seamless and highly noisy settings.

  20. Towards a Continuous Biometric System Based on ECG Signals Acquired on the Steering Wheel.

    Science.gov (United States)

    Pinto, João Ribeiro; Cardoso, Jaime S; Lourenço, André; Carreiras, Carlos

    2017-09-28

    Electrocardiogram signals acquired through a steering wheel could be the key to seamless, highly comfortable, and continuous human recognition in driving settings. This paper focuses on the enhancement of the unprecedented lesser quality of such signals, through the combination of Savitzky-Golay and moving average filters, followed by outlier detection and removal based on normalised cross-correlation and clustering, which was able to render ensemble heartbeats of significantly higher quality. Discrete Cosine Transform (DCT) and Haar transform features were extracted and fed to decision methods based on Support Vector Machines (SVM), k-Nearest Neighbours (kNN), Multilayer Perceptrons (MLP), and Gaussian Mixture Models - Universal Background Models (GMM-UBM) classifiers, for both identification and authentication tasks. Additional techniques of user-tuned authentication and past score weighting were also studied. The method's performance was comparable to some of the best recent state-of-the-art methods (94.9% identification rate (IDR) and 2.66% authentication equal error rate (EER)), despite lesser results with scarce train data (70.9% IDR and 11.8% EER). It was concluded that the method was suitable for biometric recognition with driving electrocardiogram signals, and could, with future developments, be used on a continuous system in seamless and highly noisy settings.