Twenty-fifth water reactor safety information meeting: Proceedings. Volume 1: Plenary sessions; Pressure vessel research; BWR strainer blockage and other generic safety issues; Environmentally assisted degradation of LWR components; Update on severe accident code improvements and applications

International Nuclear Information System (INIS)

Monteleone, S.

1998-03-01

This three-volume report contains papers presented at the conference. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Japan, Norway, and Russia. The titles of the papers and the names of the authors have been updated and may differ from those that appeared in the final program of the meeting. This volume contains the following information: (1) plenary sessions; (2) pressure vessel research; (3) BWR strainer blockage and other generic safety issues; (4) environmentally assisted degradation of LWR components; and (5) update on severe accident code improvements and applications. Selected papers have been indexed separately for inclusion in the Energy Science and Technology Database

33 CFR 183.534 - Fuel filters and strainers.

Science.gov (United States)

2010-07-01

... (CONTINUED) BOATING SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Equipment Standards § 183.534 Fuel filters and strainers. If tested under § 183.590, each fuel filter and strainer, as installed in the boat...

Mechanical strainer unit

International Nuclear Information System (INIS)

Kraeling, J.B.; Netkowicz, R.J.; Schnall, I.H.

1983-01-01

The mechanical strainer unit is connected to a flanged conduit which originates in and extends out of a suppression chamber in a nuclear reactor. The strainer includes a plurality of centrally apertured plates positioned along a common central axis and in parallel and spaced relationship. The plates have a plurality of bores radially spaced about the central axis. Spacer means such as washers are positioned between adjacent plates to maintain the plates is spaced relationship and form communicating passages of a predetermined size to the central apertures. Connecting means such as bolts or studs extend through the aligned bores to maintain the unit in assembled relationship and secure the unit to the pipe. By employing perforated plates and blocking off certain of the communicating passages, a dual straining effect can be achieved

Strainer device for an emergency cooling system in a nuclear power plant

International Nuclear Information System (INIS)

Trybom, J.

1997-01-01

The invention relates to a strainer device for separating contaminants from water in an emergency cooling system for a nuclear power plant. The nuclear power plant has a wet-well for water in the emergency cooling system and the strainer device comprises at least one strainer device, which is arranged in the wet-well. According to the invention the strainer is suspended in a desired position in the wet-well by means of at least a group of at least three tie rods arranged at angles to each other, each tie rod being fixed at one end to the strainer and its other end to the container or an anchor ring joined thereto. (author) figs

Design and test of ASME strainer for primary cooling system in HANARO

International Nuclear Information System (INIS)

Park, Yong-Chul; Ryu, Jeong-Soo

1999-01-01

The ASME strainers have been newly installed at the suction side of each reactor coolant pump to get rid of the foreign materials which may damage the pump impeller or interfere with the coolant path of fuel flow tube or primary plate type heat exchanger. The strainer was designed in accordance with ASME SEC. III, DIV. 1, ND and the structural integrity was verified by seismic analysis. The screen was designed in accordance with the effective void area from the result of flow analysis for T-type strainer. After installation of the strainer, it was confirmed through the field test that the flow characteristics of primary cooling system were not adversely affected. The pressure loss coefficient was calculated by Darcy equation using the pressure difference through each strainer and the flow rate measured during the strainer performance test. And these are useful data to predict flow variations by the pressure difference. (author)

Chemical environment for strainers at loss of coolant conditions in a PWR

International Nuclear Information System (INIS)

Hermansson, H.P.; Erixon, S.

1997-02-01

The present report describes the chemical environment in the neighbourhood of the strainer as a function of time after a large to medium-sized LOCA has started in a PWR. It also outlines some of the possible consequences for strainer filtration throughout the LOCA process. The most important factor for strainer behaviour is the presence of material that could be filtered onto the strainer. Examples of materials which could cause problems at strainer filtration are insulation fibers, concrete, corrosion products, paints, organic materials etc. A felt of fibrous material will probably form rapidly due to mechanical filtration on the strainers after start of recirculation. The chemistry of the strainer environment is characterized by relatively high concentrations of boric acid, lithium hydroxide and phosphate in the short time frame. Dissolved concrete and pyrolytic, acidic products could be important after 24 h. pH will be high from the very beginning of the LOCA and thereafter increase due to dissolution of Na 3 PO 4 12H 2 O placed in baskets in the containment. Mechanically induced filtration would probably be the main cause of differential pressure build-up over the strainer felt as long as pH is high enough in the sump water. pH would remain high as long as large amounts of pyrolytic products are not formed. A high pH is essential to prevent fines and small particles to coagulate and deposit which will subsequently cause differential pressure build-up over the strainers. During the first time period of strainer filtration differential pressure build-up due to mechanically induced felt growth will occur. There could also be some contribution from positively charged or almost neutral fines and particles of mineral wool, Caposil, Minileit, and organic material if present. However, this is not foreseen as a major problem as positively charged particles should be in minority. If pyrolytic production of large amounts of acidic material starts, pH could drop

Development of an amphibious robot for visual inspection of APR1400 Npp IRWST strainer

International Nuclear Information System (INIS)

Jang, You Hyun; Kim, Jong Seog

2014-01-01

An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole

Development of an amphibious robot for visual inspection of APR1400 Npp IRWST strainer

Energy Technology Data Exchange (ETDEWEB)

Jang, You Hyun; Kim, Jong Seog [Korea Hydro Nuclear Power Central Research Institute, Daejeon (Korea, Republic of)

2014-06-15

An amphibious inspection robot system (hereafter AIROS) is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST) strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of installing sole

DEVELOPMENT OF AN AMPHIBIOUS ROBOT FOR VISUAL INSPECTION OF APR1400 NPP IRWST STRAINER ASSEMBLY

Directory of Open Access Journals (Sweden)

YOU HYUN JANG

2014-06-01

Full Text Available An amphibious inspection robot system (hereafter AIROS is being developed to visually inspect the in-containment refueling storage water tank (hereafter IRWST strainer in APR1400 instead of a human diver. Four IRWST strainers are located in the IRWST, which is filled with boric acid water. Each strainer has 108 sub-assembly strainer fin modules that should be inspected with the VT-3 method according to Reg. guide 1.82 and the operation manual. AIROS has 6 thrusters for submarine voyage and 4 legs for walking on the top of the strainer. An inverse kinematic algorithm was implemented in the robot controller for exact walking on the top of the IRWST strainer. The IRWST strainer has several top cross braces that are extruded on the top of the strainer, which can be obstacles of walking on the strainer, to maintain the frame of the strainer. Therefore, a robot leg should arrive at the position beside the top cross brace. For this reason, we used an image processing technique to find the top cross brace in the sole camera image. The sole camera image is processed to find the existence of the top cross brace using the cross edge detection algorithm in real time. A 5-DOF robot arm that has multiple camera modules for simultaneous inspection of both sides can penetrate narrow gaps. For intuitive presentation of inspection results and for management of inspection data, inspection images are stored in the control PC with camera angles and positions to synthesize and merge the images. The synthesized images are then mapped in a 3D CAD model of the IRWST strainer with the location information. An IRWST strainer mock-up was fabricated to teach the robot arm scanning and gaiting. It is important to arrive at the designated position for inserting the robot arm into all of the gaps. Exact position control without anchor under the water is not easy. Therefore, we designed the multi leg robot for the role of anchoring and positioning. Quadruped robot design of

Parametric Effects of Debris Source, Environments, and Design Options on the Overall Performance of ECCS Recirculation Sump

International Nuclear Information System (INIS)

Park, Jong Woon; Kim, Chang Hyun

2006-01-01

A primary safety issue regarding long-term recirculation core cooling following a LOCA (Loss of Coolant Accident) is that LOCA-generated debris may be transported to the recirculation sump screen, resulting in adverse blockage on the sump screen and deterioration of available NPSH (Net Positive Suction Head) of ECCS (Emergency Core Cooling System). USNRC identified this as Generic Safety Issue (GSI) 191 and issued the Generic Letter 04-02 to resolve the issue. The GL required that all PWR owners perform an engineering assessment of their containment recirculation sumps to ensure they will not suffer from excessive blockage. The guidance report (GR) for PWR sump performance evaluation has been developed by NEI (Nuclear Energy Institute) and approved by the USNRC. In Korea, Korea Hydro and Nuclear Power Company (KHNP) is performing the assessment of Kori unit 1 and planning for remaining plants in the near future. The objective of the assessment is to derive required plant modifications including insulation, sump screen, etc. To derive the cost-effective modification items, we have to get insight on the parametric effects of plant conditions and design. Therefore, the general effects of debris source, containment environments and debris interceptor on the performance of ECCS recirculation sump with respect to head loss are parametrically investigated

Een nieuwe marketingcategorie: de strainer

NARCIS (Netherlands)

drs. Frans van den Reep

2013-01-01

1 alinea column: De BCG-matrix is na zesendertig jaar eindelijk aan revisie toe. De question mark, star, cash cow en dog hebben er een vriendje bij: de strainer. ‘Het vergiet’ doet zich aan de marketingstrateeg misleidend voor als een van de usual suspects, waardoor hij denkt te moeten handelen

In the Wake of the Strainer Event at Barsebaeck 2. Considerable Improvements Effected in BWR's

Energy Technology Data Exchange (ETDEWEB)

Bento, Jean-Pierre [JPB Consulting, Nykoeping (Sweden)

2003-06-01

station owners; 2. All countries undertook comprehensive analyses; 3. Exhaustive experimentation was performed in many countries; 4. Remedial actions have been taken, both technical and organizational: a. In most boiling water reactors b. In a limited number of pressurised water reactors c. In a significant number of VVER and Candu reactors 5. Tests and analyses are still going on in certain countries, mainly dealing with PWR plants. In the countries covered by the study, thorough and exhaustive analyses have been carried out to determine the quantities of insulation materials that can brake loose in the event of a pipe rupture inside the containment. Analyses have included specific modelling of the transport of insulation, and other dislodged materials, in the containment, as well as pressure losses across the strainers. This work has often been done in parallel with extensive experimentation to reveal the physical and the transient aspects of strainer blockage. Mock-ups have been prepared in some places, and full-scale tests have been performed in the wet-wells of a number of plants. The results from all this work have been used, in the first place in boiling water reactors, but also in some pressurised water reactors, to produce optimised designs for new strainers, and choices for new insulation materials. The pressurised water plants that have so far been modified are those mainly using glass-fibre and mineral wool as thermal insulation on pipe work and components in the reactor containments. This was the case, in Sweden, where changes were made to Ringhals 2. Ringhals 3 and 4 have not been modified since they have mainly reflective metallic insulation around the larger components in the containment. The picture is not clear, however, in a number of countries where pressurised water reactors still have significant amounts of glass-fibre and mineral wool in the containment buildings. This is mainly the case for the PWRs in France, Japan and the US. A periodical cleanup

Diablo Canyon ECCS enhancements

International Nuclear Information System (INIS)

Lin, A.; Lee, T.P.; Walter, L.E.

2004-01-01

Diablo Canyon Power Plant (DCPP) operated by Pacific Gas and Electric Co. (PG and E) is a Westinghouse designed four loop plant. In recent years, several issues were identified regarding the compliance of the Emergency Core Cooling System (ECCS) surveillance tests to the ECCS analyses assumptions. These concerns are related mostly to the High Head Safety Injection (HHSI) and the Intermediate Head Safety Injection (IHSI) systems where the injection line throttle valves are adjusted during outage surveillance testing to ensure compliance with the Technical Specifications (TS). To resolve all of the identified issues PG and E performed an ECCS reanalysis and upgraded the ECCS surveillance test program and also had Westinghouse perform a containment reanalysis using their latest model. As a result of these plant specific enhancement efforts, DCPP widened the operating window for TS surveillance testing, lowered the ECCS pumps' acceptance performance curves, and re-gained Peak Clad Temperature (PCT) and containment peak pressure margins. These enhancements are generically applicable to other plants and are addressed in this paper. (author)

Method of controlling ECCS system in reactors

International Nuclear Information System (INIS)

Oohashi, Hideaki; Ikehara, Morihiko.

1982-01-01

Purpose: To eliminate the risk of misoperation and thereby improve the reliability of ECCS system upon accident. Method: ECCS system for nuclear reactor is automatically started by either of signals from a water level detector in a pressure vessel or from a pressure detector in a reactor container. Further, the ECCS system is started or stopped by the manual operation irrespective of the signals, and the signals from the pressure detector are isolated from the ECCS-starting signal by the contacts which actuate interlocked with the stopping operation of the manual operation switch. Then, after stopping the ECCS system by the manual operation, the ECCS system is started by the signals from the water level detector irrespective of the signals from the pressure detector. (Seki, T.)

Final report, BWR drywell debris transport Phenomena Identification and Ranking Tables (PIRTs)

International Nuclear Information System (INIS)

Wilson, G.E.; Boyack, B.E.; Leonard, M.T.; Williams, K.A.; Wolf, L.T.

1997-09-01

The Nuclear Regulatory Commission has issued a Regulatory Bulletin and accompanying Regulatory Guide (1.82, Rev. 2) which requires licensees of boiling water reactors to develop a specific plan of action (including hardware backfits, if necessary) to preclude the possibility of early emergency core cooling system strainer blockage following a postulated loss-of-coolant-accident. The postulated mechanism for strainer blockage is destruction of piping insulation in the vicinity of the break and subsequent transport of fragmented insulation to the wetwell. In the absence of more definitive information, the Regulatory Guide recommends that licensees assume a drywell debris transport fraction of 1.0. Accordingly, the Nuclear Regulatory Commission initiated research focused toward developing a technical basis to provide insights useful to regulatory oversight of licensee submittals associated with resolution of the postulated strainer blockage issue. Part of this program was directed towards experimental and analytical research leading to a more realistic specification of the debris transport through the drywell to the wetwell. To help focus this development into a cost effective effort, a panel, with broad based knowledge and experience, was formed to address the relative importance of the various phenomena that can be expected in plant response to postulated accidents that may produce strainer blockage. The resulting phenomena identification and ranking tables reported herein were used to help guide research. The phenomena occurring in boiling water reactors drywells was the specific focus of the panel, although supporting experimental data and calculations of debris transport fractions were considered

Update Knowledge Base for Long-term Core Cooling Reliability

International Nuclear Information System (INIS)

Agrell, Maria; Sandervag, Oddbjoern; Amri, Abdallah; ); Bang, Young S.; Blomart, Philippe; Broecker, Annette; Pointner, Winfried; Ganzmann, Ingo; Lenogue, Bruno; Guzonas, David; Herer, Christophe; Mattei, Jean-Marie; Tricottet, Matthieu; Masaoka, Hideaki; Soltesz, Vojtech; Tarkiainen, Seppo; Ui, Atsushi; Villalba, Cristina; Zigler, Gilbert

2013-11-01

This revision of the Knowledge Base for Emergency Core Cooling System Recirculation Reliability (NEA/CSNI/R (95)11) describes the current status (late 2012) of the knowledge base on emergency core cooling system (ECCS) and containment spray system (CSS) suction strainer performance and long-term cooling in operating power reactors. New reactors, such as the AP1000, EPR and APR1400 that are under construction in some Organization for Economic Co-operation and Development (OECD) member countries, are not addressed in detail in this revision. The containment sump (also known as the emergency or recirculation sump in pressurized water reactors (PWRs) and pressurized heavy water reactors (PHWRs) or the suppression pools or wet wells in boiling water reactors (BWRs)) and associated ECCS strainers are parts of the ECCS in both reactor types. All nuclear power plants (NPPs) are required to have an ECCS that is capable of mitigating a design basis accident (DBA). The containment sump collects reactor coolant, ECCS injection water, and containment spray solutions, if applicable, after a loss-of-coolant accident (LOCA). The sump serves as the water source to support long-term recirculation for residual heat removal, emergency core cooling, and containment atmosphere clean-up. This water source, the related pump suction inlets, and the piping between the source and inlets are important safety-related components. In addition, if fibrous material is deposited at the fuel element spacers, core cooling can be endangered. The performance of ECCS/CSS strainers was recognized many years ago as an important regulatory and safety issue. One of the primary concerns is the potential for debris generated by a jet of high-pressure coolant during a LOCA to clog the strainer and obstruct core cooling. The issue was considered resolved for all reactor types in the mid-1990s and the OECD/NEA/CSNI published report NEA/CSNI/R(95)11 in 1996 to document the state of knowledge of ECCS performance

Advanced DVI for ECC direct bypass mitigation

International Nuclear Information System (INIS)

Kwon, Tae-Soon; Song, Chul-Hwa; Baek, Won-Pil

2009-01-01

An ECC direct bypass fraction during a late reflood phase of a LBLOCA is strongly dependent on the characteristics of the cross flow and the geometrical configuration of a DVI in the downcomer of a pressurized light water reactor. The important design parameters of a DVI are the elevation, the azimuthal angle, and the separator to prevent a steam-water interaction. An ECC sub-channel to separate or to isolate an ECC water from a high-speed cross flow is one of the important design features to mitigate the ECC bypass phenomena. A dual core barrel cylinder as an ECC flow separator is located between a reactor vessel and a core barrel outer wall in the downcomer annulus. A new narrow gap between the core barrel and the additional dual core barrel plays the role of a downward ECC flow channel or an ECC flow separator in a high-speed cross flow field of the downcomer annulus. The flow zone around a broken cold leg in the downcomer annulus has the role of a high ECC direct bypass due to a strong suction force while the wake zone of a hot leg has the role of an ECC penetration. Thus, the relative azimuthal angle of the DVI nozzle from the broken cold leg is an important design parameter. A large azimuthal angle from a cold leg to a hot leg needs to avoid a high suction flow zone when an ECC water is being injected. The other enhancing mechanism of an ECC penetration is a grooved core barrel which has small rectangular-shaped grooves vertically arranged on the core barrel wall of the reactor vessel downcomer annulus. These grooves have the role for a generation of a vortex induced by a high-speed cross flow. Since the stagnant flow in a lateral direction and rotational vortex provides the pulling force of an ECC drop or film to flow down into the lower downcomer annulus by gravity, the ECC direct bypass fraction is reduced when compared to the current design of a smoothed wall. An open channel of grooves generates a stagnant vortex, while a closed channel of grooves

Evaluation of precipitates used in strainer head loss testing. Part I. Chemically generated precipitates

International Nuclear Information System (INIS)

Bahn, Chi Bum; Kasza, Ken E.; Shack, William J.; Natesan, Ken; Klein, Paul

2009-01-01

The purpose of the current program was to evaluate the properties of chemical precipitates proposed by industry that have been used in sump strainer head loss testing. Specific precipitates that were evaluated included aluminum oxyhydroxide (AlOOH) and sodium aluminum silicate (SAS) prepared according to the procedures in WCAP-16530-NP, along with precipitates formed from injecting chemicals into the test loop according to the procedure used by one sump strainer test vendor for U.S. pressurized water reactors. The settling rates of the surrogate precipitates are strongly dependent on their particle size and are reasonably consistent with those expected from Stokes' Law or colloid aggregation models. Head loss tests showed that AlOOH and SAS surrogates are quite effective in increasing the head loss across a perforated pump inlet strainer that has an accumulated fibrous debris bed. The characteristics of aluminum hydroxide precipitate using sodium aluminate were dependent on whether it was formed in high-purity or ordinary tap water and whether excess silicate was present or not.

CHEMICAL EFFECTS ON PWR SUMP STRAINER BLOCKAGE AFTER A LOSS-OF-COOLANT ACCIDENT: REVIEW ON U.S. RESEARCH EFFORTS

Directory of Open Access Journals (Sweden)

CHI BUM BAHN

2013-06-01

Full Text Available Industry- or regulatory-sponsored research activities on the resolution of Generic Safety Issue (GSI-191 were reviewed, especially on the chemical effects. Potential chemical effects on the head loss across the debris-loaded sump strainer under a post-accident condition were experimentally evidenced by small-scale bench tests, integrated chemical effects test (ICET, and vertical loop head loss tests. Three main chemical precipitates were identified by WCAP-16530-NP: calcium phosphate, aluminum oxyhydroxide, and sodium aluminum silicate. The former two precipitates were also identified as major chemical precipitates by the ICETs. The assumption that all released calcium would form precipitates is reasonable. CalSil insulation needs to be minimized especially in a plant using trisodium phosphate buffer. The assumption that all released aluminum would form precipitates appears highly conservative because ICETs and other studies suggest substantial solubility of aluminum at high temperature and inhibition of aluminum corrosion by silicate or phosphate. The industry-proposed chemical surrogates are quite effective in increasing the head loss across the debris-loaded bed and more effective than the prototypical aluminum hydroxide precipitates generated by in-situ aluminum corrosion. There appears to be some unresolved potential issues related to GSI-191 chemical effects as identified in NUREG/CR-6988. The United States Nuclear Regulatory Commission, however, concluded that the implications of these issues are either not generically significant or are appropriately addressed, although several issues associated with downstream in-vessel effects remain.

Emergency response guide-B ECCS guideline evaluation analyses for N reactor

International Nuclear Information System (INIS)

Chapman, J.C.; Callow, R.A.

1989-07-01

INEL conducted two ECCS analyses for Westinghouse Hanford. Both analyses will assist in the evaluation of proposed changes to the N Reactor Emergency Response Guide-B (ERG-B) Emergency Core System (ECCS) guideline. The analyses were a sensitivity study for reduced-ECCS flow rates and a mechanistically determined confinement steam source for a delayed-ECCS LOCA sequence. The reduced-ECCS sensitivity study established the maximum allowable reduction in ECCS flow as a function of time after core refill for a large break loss-of-coolant accident (LOCA) sequence in the N Reactor. The maximum allowable ECCS flow reduction is defined as the maximum flow reduction for which ECCS continues to provide adequate core cooling. The delayed-ECCS analysis established the liquid and steam break flows and enthalpies during the reflood of a hot core following a delayed ECCS injection LOCA sequence. A simulation of a large, hot leg manifold break with a seven-minute ECCS injection delay was used as a representative LOCA sequence. Both analyses were perform using the RELAP5/MOD2.5 transient computer code. 13 refs., 17 figs., 3 tabs

Design approach to local blockages

International Nuclear Information System (INIS)

Roychowdhury, D.G.; Govindarajan, S.; Chetal, S.C.; Bhoje, S.B.

2000-01-01

In LMFBR, whole core meltdown accident falls in residual risk category. Propagation of a local fault to whole core, however, needs attention. Subassembly accidents are divided into two categories, Design Basis and Beyond Design Basis accidents. Design Basis is further classified into four categories. All events affecting fuel pin performance are identified and categorised, Total Instantaneous Blockage has been identified as the envelope of all local faults and categorised as BDB event and the safety objective is to demonstrate that no damage will propagate beyond six neighbouring SA. A core catcher has been provided for retention of core debris and cooling it by natural convection. Local blockages may be active and passive. Active blockages can be detected by DND signal. For passive blockages, detection is difficult. Hence, development of a finite volume computer code based on the porous body formulation has been undertaken to define the maximum allowable defect. Experimental programmes have been undertaken to understand blockage mechanism, define maximum credible defect and the thermalhydraulic behaviour of SA with local blockages. Also an experimental programme with a totally blocked SA with a bundle of heated pins has been undertaken to understand the behaviour of the SA. (author)

Shear behavior of reinforced Engineered Cementitious Composites (ECC) beams

DEFF Research Database (Denmark)

Paegle, Ieva; Fischer, Gregor

2010-01-01

This paper describes an experimental investigation of the shear behavior of beams consisting of steel reinforced Engineered Cementitious Composites (ECC). Based on the strain hardening and multiple cracking behavior of ECC, this study investigates the extent to which ECC can improve the shear...... capacity of beams loaded primarily in shear and if ECC can partially or fully replace the conventional transverse steel reinforcement in beams. However, there is a lack of understanding of how the fibers affect the shear carrying capacity and deformation behavior of structural members if used either...

ECCS Operability With One or More Subsystem(s) Inoperable

International Nuclear Information System (INIS)

Swantner, Stephen R.; Andrachek, James D.

2002-01-01

Plant Technical Specifications are issued by the US NRC to ensure that safe nuclear power plant operation is maintained within the assumptions for parameters and Structures, Systems, and Components (SSCs) made in the plant safety analysis reports. The Technical Specifications are made up of Limiting Conditions for Operation (LCOs), which are the minimum set of requirements that must be met based on the assumptions of the safety analysis, Actions, which are the remedial or compensatory actions that must be taken if the LCO is not met, and Surveillance Requirements, that demonstrate that the LCO is met. The Technical Specification Actions contain Completion Times (CTs) which are the time within which remedial actions must be taken, in the event that the LCO is not met. The Improved Standard Technical Specifications (ISTS) for Westinghouse plants are contained in NUREG-1431, Revision 2. Condition A of Technical Specification 3.5.2 (ECCS- Operating) in NUREG-1431, Revision 2, allows components to be taken out of service for up to 72 hours, as long as 100% of the ECCS flow equivalent to a single Operable ECCS train exists. Condition A would allow, for example, the A train low head safety injection (LHSI) and the B train high head safety injection (HHSI) pumps to be taken out of service (for 72 hours) as long as it could be demonstrated that the remaining components could provide 100% train equivalent flow capacity. The 'cross-training' allowed by this Condition in the ISTS provides flexibility when performing routine pre-planned preventive maintenance and testing, as well as during emergent corrective maintenance and testing associated with random component inoperabilities. Without this flexibility, a unit would have to initiate a plant shutdown within 1 hour, if component(s) were inoperable in different trains. In order to implement this flexibility, the various combinations of components in opposite trains must be evaluated to determine whether 100% of the ECCS flow

Debris impact on emergency coolant recirculation - summary and conclusions

International Nuclear Information System (INIS)

Jain, Bhagwat; Hsia, Anthony; Armand, Yves; Mattei, Jean-Marie; Hyvaerinen, Juhani; Maqua, Michael; Puetter, Bernhard; Sandervaag, Oddbjoern; Vandewalle, Andre; Tombuyses, Beatrice; Pyy, Pekka; Royen, Jacques

2004-01-01

On 28 July 1992, a steam line safety relief valve inadvertently opened in the Barsebaeck-2 nuclear power plant in Sweden. The steam jet stripped fibrous insulation from adjacent piping system. Part of that insulation debris was transported to the wet-well pool and clogged the intake strainers for the drywell spray system after about one hour. Although the incident in itself was not very serious, it revealed a weakness in the defense-in-depth concept which under other circumstances could have led to the emergency core cooling system (ECCS) failing to provide recirculation water to the core. The Barsebaeck incident spurred immediate action on the part of regulators and utilities alike in several OECD countries. Research and development efforts of varying degrees of intensity were launched in many countries and in several cases resulted in findings that earlier strainer clogging data were incorrect because essential parameters and physical phenomena had not been recognized previously. Such efforts resulted in substantial back-fittings being carried out for BWRs and some PWRs in several OECD countries. An international workshop organised in Stockholm in 1994 under the auspices of CSNI revealed a rather confusing picture of the available knowledge base, examples of conflicting information and a wide range of interpretation of guidance for assessing BWR strainers and PWR sump screen performance contained in US NRC Regulatory Guide 1.82. An International Working Group was set up by the CSNI to establish an internationally agreed-upon knowledge base for assessing the reliability of ECC water recirculation systems. An initiative was taken by the CSNI in 1998 to revisit the subject. The general objective was to make an update of the knowledge base for strainer clogging, to review the latest phenomena for PWRs and to provide a survey of actions taken in member countries. New information contained in NUREG/CR-6771 indicated that the core damage frequency could increase by one

The microstructure of self-healed PVA ECC under wet and dry cycles

Directory of Open Access Journals (Sweden)

Jia Huan Yu

2010-06-01

Full Text Available Self-healing of ECC (Engineered Cementitious Composites subjected to cyclic wetting and drying regimes is investigated in this paper. ECC structures subjected to outdoor environmental conditions such as wind and rain runoff can be simulated by accelerated test method of wetting and drying cycles. Uniaxial tensile tests of ECC M45 and ECC 2.8FA specimen are conducted respectively. It is found that crack width of ECC 2.8FA is around 10 μm with increased amount of fly ash, while the crack width of ECC M45 is around 100 μm. New insights about the microstructure and chemical composition analysis of ECC specimens initially cracked to 2% strain and then self-healed under wet-dry cycles are presented.

Condensation during gravity driven ECC: Experiments with PACTEL

Energy Technology Data Exchange (ETDEWEB)

Munther, R.; Kalli, H. [Lappeenranta Univ. of Technology (Finland); Kouhia, J. [Technical Research Centre of Finland, Lappeenranta (Finland)

1995-09-01

This paper provides the results of the second series of gravity driven emergency core cooling (ECC) experiments with PACTEL (Parallel Channel Test Loop). The simulated accident was a small break loss-of-coolant accident (SBLOCA) with a break in a cold leg. The ECC flow was provided from a core makeup tank (CMT) located at a higher elevation than the main part of the primary system. The CMT was pressurized with pipings from the pressurizer and a cold leg. The tests indicated that steam condensation in the CMT can prevent ECC and lead to core uncovery.

Blockages in LMFBR fuel assemblies: a review

International Nuclear Information System (INIS)

Han, J.T.; Fontana, M.H.

1977-01-01

Experimental and analytical investigations performed in the United States, Germany, Great Britain, and Japan on the effects of partial flow blockages in liquid-metal fast breeder reactor fuel assemblies are reviewed and the results presented. Generalized models are developed from experimental data obtained for blockages of various sizes, shapes, and porosity, with and without pins, utilizing water and sodium as the coolant. Generally, the recirculating flow in the wake behind a blockage is a relatively effective heat transfer mechanism. Experiments where sodium boiling was made to occur behind the blockages indicate that boiling is stable for the configurations tested; these results are predicted by analytical models. Blockages at the inlet of fuel assemblies tend to have insignificant effects in the fuel assembly unless flow is reduced grossly and therefore would be detectable. Blockages in the heat generating zone have to be quite large to cause sodium boiling under normal reactor operating conditions

Blockages in LMFBR fuel assemblies: a review

Energy Technology Data Exchange (ETDEWEB)

Han, J T; Fontana, M H

1977-01-01

Experimental and analytical investigations performed in the United States, Germany, Great Britain, and Japan on the effects of partial flow blockages in liquid-metal fast breeder reactor fuel assemblies are reviewed and the results presented. Generalized models are developed from experimental data obtained for blockages of various sizes, shapes, and porosity, with and without pins, utilizing water and sodium as the coolant. Generally, the recirculating flow in the wake behind a blockage is a relatively effective heat transfer mechanism. Experiments where sodium boiling was made to occur behind the blockages indicate that boiling is stable for the configurations tested; these results are predicted by analytical models. Blockages at the inlet of fuel assemblies tend to have insignificant effects in the fuel assembly unless flow is reduced grossly and therefore would be detectable. Blockages in the heat generating zone have to be quite large to cause sodium boiling under normal reactor operating conditions.

75 FR 41241 - Draft Regulatory Guide; Issuance, Availability

Science.gov (United States)

2010-07-15

...: (301) 251-7404 or e-mail [email protected] . SUPPLEMENTARY INFORMATION: I. Introduction The U.S... analysis and testing applicable to Emergency Core Cooling System (ECCS) strainer performance and debris... provides text and image files of NRC's public documents. If you do not have access to ADAMS or if there are...

Numerical simulation of the insulation material transport to a PWR core under loss of coolant accident conditions

International Nuclear Information System (INIS)

Höhne, Thomas; Grahn, Alexander; Kliem, Sören; Rohde, Ulrich; Weiss, Frank-Peter

2013-01-01

Highlights: ► Detailed results of a numerical simulation of the insulation material transport to a PWR core are shown. ► The spacer grid is modeled as a strainer which completely retains the insulation material carried by coolant. ► The CFD calculations showed that the fibers at the upper spacer grid plane are not uniformly distributed. ► Furthermore the pressure loss does not exceed a critical limit. ► The PWR core coolablity can be guaranteed all the time during the transient. -- Abstract: In 1992, strainers on the suction side of the ECCS pumps in Barsebäck NPP Unit 2 became partially clogged with mineral wool because after a safety valve opened the steam impinged on thermally insulated equipment and released mineral wool. This event pointed out that strainer clogging is an issue in the course of a loss-of-coolant accident. Modifications of the insulation material, the strainer area and mesh size were carried out in most of the German NPPs. Moreover, back flushing procedures to remove the mineral wool from the strainers and differential pressure measurements were implemented to assure the performance of emergency core cooling during the containment sump recirculation mode. Nevertheless, it cannot be completely ruled out, that a limited amount of small fractions of the insulation material is transported into the RPV. During a postulated cold leg LOCA with hot leg ECC injection, the fibers enter the upper plenum and can accumulate at the fuel element spacer grids, preferably at the uppermost grid level. This effect might affect the ECC flow into the core and could result in degradation of core cooling. It was the aim of the numerical simulations presented to study where and how many mineral wool fibers are deposited at the upper spacer grid. The 3D, time dependent, multi-phase flow problem was modeled applying the CFD code ANSYS CFX. The CFD calculation does not yet include steam production in the core and also does not include re-suspension of the

Development of Calculation Algorithm for ECCS Kinematic Shock

Energy Technology Data Exchange (ETDEWEB)

Lee, Seung-Chan; Yoon, Duk-Joo; Ha, Sang-Jun [KHNP-CRI, Daejeon (Korea, Republic of)

2014-10-15

The void fraction of inverted U-pipes in front of SI(Safety Injection) pumps impact on the pipe system of ECCS(Emergency Core Cooling Systems). This phenomena is called as 'Kinematic Shock'. The purpose of this paper is to achieve the more exactly calculation when the kinematic shock is calculated by simplified equation. The behavior of the void packet of the ECCS pipes is illustrated by the simplified (other name is kinematic shock equation).. The kinematic shock is defined as the depth of total length of void clusters in the pipes of ECCS when the void cluster is continually reached along the part of pipes in vertical direction. In this paper, the simplified equation is evaluated by comparing calculation error each other.]. The more exact methods of calculating the depth of the kinematic shock in ECCS is achieved. The error of kinematic shock calculation is strongly depended on the calculation search gap and the order of Taylor's expansion. From this study, to select the suitable search gap and the suitable calculation order, differential root method, secant method, and Taylor's expansion form are compared one another.

Method and device for controlling ECCS

International Nuclear Information System (INIS)

Ikeda, Takashi; Kataoka, Yoshiyuki; Murase, Michio.

1986-01-01

Purpose: To accomplish reactor cooling without exposing fuel assemblies out of the coolant and also without inducing counter-current flow (CCFL) brake likely to be caused by excess injection of water even in case of malfunction of one system in a loss-of-coolant accident. Method: In a BWR type reactor having more than two independent ECCS, the lower plenum water level is measured and when the lower plenum is full of water, the ECCS are kept in a fully closed state, and reversely when the lower plenum is not full of water, more coolant than the lost quantity of water will be injected into the plenum at a higher pressure than a pressure at which fuel rods just begin to be exposed to the steam phase. The subcool energy of the emergency coolant to be injected is determined by the decay heat of the core and the change rate of a container pressure. However, the quantity of the emergency coolant is controlled such that the subcool energy will always become less than the overheating energy in the core range and the lower plenum range, thus improving safety and enabling the removal of a prior-art ECCS. (Kamimura, M.)

Evaluation of mispositioned ECCS valves

International Nuclear Information System (INIS)

Hill, R.A.; O'Brien, J.F.; McIntire, D.C.; Barlow, R.T.

1977-09-01

In October of 1975, Westinghouse submitted NS-CE-787, dated October 17, 1975, to the Nuclear Regulatory Commission (NRC) and entered into discussions with them concerning the spurious movement of certain motor-operated valves (MOV's) in the Emergency Core Cooling System (ECCS) to a position defeating the ECCS function at a time when this function is required. On November 25, 1975, the discussion turned to the possible movement of a manually controlled, motor-operated valve due to a fault in its electrical circuitry and the NRC staff expressed concerns about other possible failure modes that might lead to such a valve movement. The NRC meeting minutes document these concerns. This report is an item-by-item response to the concerns expressed by the NRC staff at that meeting and incorporates the original electrical fault analysis

Energy-dissipating and self-repairing SMA-ECC composite material system

International Nuclear Information System (INIS)

Li, Xiaopeng; Li, Mo; Song, Gangbing

2015-01-01

Structural component ductility and energy dissipation capacity are crucial factors for achieving reinforced concrete structures more resistant to dynamic loading such as earthquakes. Furthermore, limiting post-event residual damage and deformation allows for immediate re-operation or minimal repairs. These desirable characteristics for structural ‘resilience’, however, present significant challenges due to the brittle nature of concrete, its deformation incompatibility with ductile steel, and the plastic yielding of steel reinforcement. Here, we developed a new composite material system that integrates the unique ductile feature of engineered cementitious composites (ECC) with superelastic shape memory alloy (SMA). In contrast to steel reinforced concrete (RC) and SMA reinforced concrete (SMA-RC), the SMA-ECC beams studied in this research exhibited extraordinary energy dissipation capacity, minimal residual deformation, and full self-recovery of damage under cyclic flexural loading. We found that the tensile strain capacity of ECC, tailored up to 5.5% in this study, allows it to work compatibly with superelastic SMA. Furthermore, the distributed microcracking damage mechanism in ECC is critical for sufficient and reliable recovery of damage upon unloading. This research demonstrates the potential of SMA-ECC for improving resilience of concrete structures under extreme hazard events. (paper)

Fundamental water experiment on subassembly with porous blockage in 4 sub-channel geometry. Influence of flow on temperature distribution in the porous blockage

International Nuclear Information System (INIS)

Tanaka, Masa-aki; Kobayashi, Jun; Isozaki, Tadasi; Nishimura, Motohiko; Kamide, Hideki

1998-03-01

In the liquid metal cooled Fast Breeder Reactor, Local Fault incident is recognized as a key issue of the local subassembly accident. In terms of the reactor safety assessment, it is important to predict the velocity and temperature distributions not only in the fuel subassembly but also in the blockage accurately to evaluate the location of the hottest point and the maximum temperature. In this study, the experiment was performed with the 4 sub-channel geometry water test facility. Dimension is five times larger than that of a real FBR. The porous blockage is located at the center sub-channel in the test section and surrounded with three unplugged sub-channels. The blockages used in this study were, the solid metal, the porous medium consisted of metal spheres, the porous blockage with end plates covering the side or top faces of the blockage to prevent the horizontal and axial flows into the blockage. The experimental parameters were the heater output provided by the electrical heater in the simulated fuel pins and the flow rate. Temperature of the fluid was measured inside/outside the blockage and velocity profiles outside the blockage were measured. (J.P.N.)

Preliminary Evaluation Methodology of ECCS Performance for Design Basis LOCA Redefinition

International Nuclear Information System (INIS)

Kang, Dong Gu; Ahn, Seung Hoon; Seul, Kwang Won

2010-01-01

To improve their existing regulations, the USNRC has made efforts to develop the risk-informed and performance-based regulation (RIPBR) approaches. As a part of these efforts, the rule revision of 10CFR50.46 (ECCS Acceptance Criteria) is underway, considering some options for 4 categories of spectrum of break sizes, ECCS functional reliability, ECCS evaluation model, and ECCS acceptance criteria. Since the potential for safety benefits and unnecessary burden reduction from design basis LOCA redefinition is high relative to other options, the USNRC is proceeding with the rulemaking for design basis LOCA redefinition. An instantaneous break with a flow rate equivalent to a double ended guillotine break (DEGB) of the largest primary piping system in the plant is widely recognized as an extremely unlikely event, while redefinition of design basis LOCA can affect the existing regulatory practices and approaches. In this study, the status of the design basis LOCA redefinition and OECD/NEA SMAP (Safety Margin Action Plan) methodology are introduced. Preliminary evaluation methodology of ECCS performance for LOCA is developed and discussed for design basis LOCA redefinition

The prevalence and risks of early childhood caries (ECC) in Toronto, Canada.

Science.gov (United States)

Al-Jewair, Thikriat S; Leake, James L

2010-10-14

To determine the prevalence and risks of early childhood caries (ECC) among children less than 71 months of age in Toronto, Canada, and to evaluate the association between parental/caregiver depression and ECC. A secondary analysis of data previously collected by the Toronto Public Health as part of the 2003 Toronto Perinatal and Child Health Survey was performed. The 90-item survey was conducted over the telephone to 1,000 families with children from zero years (birth) to six years of age. Parents/caregivers were asked about factors related to the development and health of their children. For this study, only children younger than six years of age (less than 71 months) were included (n=833). The primary outcome of interest was self-reported and measured by the response to the question of whether a physician/dentist had ever told the parent/caregiver his/her child had ECC. The prevalence of ECC was 4.7 percent (37 of 791 children). The child's age, his/her history of dental visits, teeth brushing, the use of fluoridated toothpaste, the parent's/caregiver's depressive tendencies, the language spoken at home, and the household annual income were all significant in the bivariate analysis. Multiple logistic regression identified four factors associated with ECC: the child's age (being three years of age or older), having at least one parent/caregiver with depression, not speaking English at home, and having an annual household income less than $40,000 in Canadian dollars (CAD). While a child's age, home language, and household income are known risks for ECC, the finding that parental/caregiver depression may be related to ECC is new. Multiple risk factors are involved in the development of early childhood caries. Of particular importance are demographic (e.g., child's age), social (e.g., annual household income), and psychosocial factors (e.g., parental/caregiver depression) that are indirectly linked to ECC. More attention needs to be placed on understanding the role

Decision Support System for Blockage Management in Fire Service

Directory of Open Access Journals (Sweden)

Krasuski Adam

2014-08-01

Full Text Available In this article we present the foundations of a decision support system for blockage management in Fire Service. Blockage refers to the situation when all fire units are out and a new incident occurs. The approach is based on two phases: off-line data preparation and online blockage estimation. The off-line phase consists of methods from data mining and natural language processing and results in semantically coherent information granules. The online phase is about building the probabilistic models that estimate the block-age probability based on these granules. Finally, the selected classifier judges whether a blockage can occur and whether the resources from neighbour fire stations should be asked for assistance.

Heat transfer in tube bundles subjected to blockages. Pt. 1

International Nuclear Information System (INIS)

Khattab, M.; Mariy, A.; Habib, M.

1983-01-01

The present work is carried out on unblocked test section bundle, half blocked, single ballooning and four ballooning blockages. The hydro-thermal performance of the bundle, (4x4) stainless steel, under each of the previous cases are studied. It is found that the existance of blockages increases the eddies and swirling flow streams. Furthermore, the average heat transfer in a bundle without blockages is superior than that with blockages. The percentage decrease of the average heat transfer coefficient with blockages depends on the position and shape of the blockage. Correlations describing average heat transfer, pressure drop and friction factor are established. All experimental tests are carried out under non-boiling region. (orig.) [de

Review on the NEI Methodology of Debris Transport Analysis in Sump Blockage Issue for APR1400

International Nuclear Information System (INIS)

Kim, Jong Uk; Lee, Jeong Ik; Hong, Soon Joon; Lee, Byung Chul; Bang, Young Seok

2007-01-01

Since USNRC (United State Nuclear Regulatory Committee) initially addressed post-accident sump performance under Unresolved Safety Issue USI A-43, sump blockage issue has gone through GSI-191, Regulation Guide 1.82, Rev. 3 (RG. 1.82 Rev.3), and generic Letter 2004-02 for PWRs (Pressurized Water Reactors). As a response of these USNRC's activities, NEI 04-07 was issued in order to evaluate the post-accident performance of a plant's recirculation sump. The baseline methodology of NEI 04-07 is composed of break selection, debris generation, latent debris, debris transport, and head loss. In analytical refinement of NEI 04-07, computational fluid dynamic (CFD) is suggested for the evaluation of debris transport in emergency core cooling (ECC) recirculation mode as guided by RG. 1.82 Rev.3. In Korea nuclear industry also keeps step with international activities of this safety issue, with Kori 1 plant as a pioneering edge. Korean nuclear industry has been also pursuing development of an advanced PWR of APR1400, which incorporates several improved safety features. One of the key features, considering sump blockage issue, is the adoption of IRWST (In-containment Refueling Water Storage Tank). This device, as the acronym implies, changes the emergency core cooling water injection pattern. This fact makes us to review the applicability of NEI 04-07's methodology. In this paper we discuss the applicability of NEI 04- 07's methodology, and more over, new methodology is proposed. And finally the preliminary debris transport is analyzed

Advanced neutron source reactor probabilistic flow blockage assessment

International Nuclear Information System (INIS)

Ramsey, C.T.

1995-08-01

The Phase I Level I Probabilistic Risk Assessment (PRA) of the conceptual design of the Advanced Neutron Source (ANS) Reactor identified core flow blockage as the most likely internal event leading to fuel damage. The flow blockage event frequency used in the original ANS PRA was based primarily on the flow blockage work done for the High Flux Isotope Reactor (HFIR) PRA. This report examines potential flow blockage scenarios and calculates an estimate of the likelihood of debris-induced fuel damage. The bulk of the report is based specifically on the conceptual design of ANS with a 93%-enriched, two-element core; insights to the impact of the proposed three-element core are examined in Sect. 5. In addition to providing a probability (uncertainty) distribution for the likelihood of core flow blockage, this ongoing effort will serve to indicate potential areas of concern to be focused on in the preliminary design for elimination or mitigation. It will also serve as a loose-parts management tool

Holistic care patient with Early Childhood Caries (ECC: A case report

Directory of Open Access Journals (Sweden)

Intan Maulani

2016-06-01

Full Text Available Early Childhood Caries (ECC is a specific form of severe dental caries that affects infants and young children. ECC progresses rapidly in those who are at high risk, and often goes untreated. Children experiencing caries as infants or toddlers have a much greater probability of subsequent caries in both primary and permanent dentitions. This case showed management holistic care for children with ECC.A five year old boy patient accompanied with her parents were reported to the Pedodontic Clinic Padjadjaran University Dental Hospital with a chief complaint of decayed upper anterior teeth and pain in the molar teeth. Clinical examinations found dental caries almost all teeth in the maxilla and mandible. Based on panoramic radiograph, treatments that can be done are strip crown glass ionomer restorations, pulp treatments, extractions and fixed space maintainer. Patients diagnosed with severe ECC, patient and parents described on this type of caries. During treatment the patient was given oral hygiene instruction and recommend daily use of tooth mouse. After all treatment were completed, fluoride topical, and fissure sealants, recall check up after three months was scheduled. Holistic care needed in handling children with ECC.

A LOCA analysis for AHWR caused by ECCS header rupture

International Nuclear Information System (INIS)

Chatterjee, B.; Gawai, Amol; Gupta, S.K.; Kushwaha, H.S.

2000-01-01

Loss of coolant accident (LOCA) analyses for the proposed 750 MWth Advanced Heavy Water Reactor (AHWR), initiated by the rupture of 8 inch NB ECCS header has been carried out. This paper narrates the description of AHWR and associated ECCS, postulated scenario with which the analyses is carried out, results, discussion and conclusion

Nuclear safety - Topical issues

International Nuclear Information System (INIS)

1995-01-01

The following topical issues related to nuclear safety are discussed: steam generators; maintenance strategies; control rod drive nozzle cracks; core shrouds cracks; sump strainer blockage; fire protection; computer software important for safety; safety during shutdown; operational safety experience; external hazards and other site related issues. 5 figs, 5 tabs

Is 300 Seconds ACT Safe and Efficient during MiECC Procedures?

Science.gov (United States)

Bauer, Adrian; Hausmann, Harald; Schaarschmidt, Jan; Szlapka, Michal; Scharpenberg, Martin; Eberle, Thomas; Hasenkam, J Michael

2017-12-31

 The recommended minimum activated clotting time (ACT) level for cardiopulmonary bypass (CPB) of 480 seconds originated from investigations with bubble oxygenators and uncoated extracorporeal circulation (ECC) systems. Modern minimal invasive ECC (MiECC) systems are completely closed circuits containing a membrane oxygenator and a tip-to-tip surface coating. We hypothesized that surface coating and the "closed-loop" design allow the MiECC to safely run with lower ACT levels and that an ACT level of 300 seconds can be safely applied without thromboembolic complications. The aim of this study was to investigate the potential risks during application of reduced heparin levels in patients undergoing coronary surgery.  In this study, 68 patients undergoing coronary artery bypass grafting with MiECC were randomized to either the study group with an ACT target of 300 seconds or the control group with an ACT of 450 seconds. All other factors of MiECC remained unchanged.  The study group received significantly less heparin and protamine (heparin [international units] median [min-max], Red_AC: 32,800 [23,000-51,500] vs. Full_AC: 50,000 [35,000-65,000] p  ACT in the study group was significantly lower at the start of MiECC (mean ± standard deviation: study group 400 ± 112 vs. control group 633 ± 177; p  ACT levels were: study group 344 ± 60 versus control group 506 ± 80. In both groups, the values of the endogenous thrombin potential (ETP) decreased simultaneously. None of the study participants experienced thromboembolic complications.  Since no evidence of increased thrombin formation (ETP) was found from a laboratory standpoint, we concluded that the use of MiECC with a reduced anticoagulation strategy seems possible. This alternative anticoagulation strategy leads to significant reduction in dosages of both heparin and protamine. We can confidently move forward with investigating this anticoagulation concept. However, to

Core-power and decay-time limits for disabled automatic-actuation of LOFT ECCS

International Nuclear Information System (INIS)

Hanson, G.H.

1978-01-01

The Emergency Core Cooling System (ECCS) for the LOFT reactor may need to be disabled for modifications or repairs of hardware or instrumentation or for component testing during periods when the reactor system is hot and pressurized, or it may be desirable to enable the ECCS to be disabled without the necessity of cooling down and depressurizing the reactor. A policy involves disabling the automatic-actuation of the LOFT ECCS, but still retaining the manual actuation capability. Disabling of the automatic actuation can be safely utilized, without subjecting the fuel cladding to unacceptable temperatures, when the LOFT power decays to 33 kW; this power level permits a maximum delay of 20 minutes following a LOCA for the manual actuation of ECCS. For the operating power of the L2-2 Experiment, the required decay-periods (with operating periods of 40 and 2000 hours) are about 21 and 389 hours, respectively. With operating periods of 40 and 2000 hours at Core-I full power, the required decay-periods are about 42 and 973 hours, respectively. After these decay periods the automatic actuation of the LOFT ECCS can be disabled assuming a maximum delay of 20 minutes following a LOCA for the manual actuation of ECCS. The automatic and manual lineup of the ECCS may be waived if decay power is less than 11 kW

Core-power and decay-time limits for disabled automatic-actuation of LOFT ECCS

International Nuclear Information System (INIS)

Hanson, G.H.

1978-01-01

The Emergency Core Cooling System (ECCS) for the LOFT reactor may need to be disabled for modifications or repairs of hardware or instrumentation or for component testing during periods when the reactor system is hot and pressurized, or it may be desirable to enable the ECCS to be disabled without the necessity of cooling down and depressurizing the reactor. LTR 113-47 has shown that the LOFT ECCS can be safely bypassed or disabled when the total core power does not exceed 25 kW. A modified policy involves disabling the automatic actuation of the LOFT ECCS, but still retaining the manual activation capability. Disabling of the automatic actuation can be safely utilized, without subjecting the fuel cladding to unacceptable temperatures, when the LOFT power decays to 70 kW; this power level permits a maximum delay of 20 minutes following a LOCA for the manual actuation of ECCS

ECC cusp analysis

Energy Technology Data Exchange (ETDEWEB)

Pregliasco, R.G. (Centro Atomico Bariloche and CONICET, S.C. de Bariloche (Argentina)); Garibotti, C.R. (Centro Atomico Bariloche and CONICET, S.C. de Bariloche (Argentina)); Barrachina, R. (Centro Atomico Bariloche and CONICET, S.C. de Bariloche (Argentina))

1994-03-01

We measured the ionization double differential cross section for the H[sup +][yields]He 100 keV collision at the proximities of the ECC cusp and all around 0 . We propose an angular function expansion and a procedure for data analysis. We demonstrate that, in this way, the difficulties and shortcomings presented in the standard data processing are overcome. In our experimental results we distinguish the presence of characteristic shapes for the ionization depending on whether the module of the electron velocity is greater or smaller than the projectile velocity. (orig.)

In-situ Blockage Monitoring of Sensing Line

Directory of Open Access Journals (Sweden)

Aijaz Ahmed Mangi

2016-02-01

Full Text Available A reactor vessel level monitoring system measures the water level in a reactor during normal operation and abnormal conditions. A drop in the water level can expose nuclear fuel, which may lead to fuel meltdown and radiation spread in accident conditions. A level monitoring system mainly consists of a sensing line and pressure transmitter. Over a period of time boron sediments or other impurities can clog the line which may degrade the accuracy of the monitoring system. The aim of this study is to determine blockage in a sensing line using the energy of the composite signal. An equivalent Pi circuit model is used to simulate blockages in the sensing line and the system's response is examined under different blockage levels. Composite signals obtained from the model and plant's unblocked and blocked channels are decomposed into six levels of details and approximations using a wavelet filter bank. The percentage of energy is calculated at each level for approximations. It is observed that the percentage of energy reduces as the blockage level in the sensing line increases. The results of the model and operational data are well correlated. Thus, in our opinion variation in the energy levels of approximations can be used as an index to determine the presence and degree of blockage in a sensing line.

Measurement of blockage in deformed LWR multi-rod arrays

International Nuclear Information System (INIS)

Hindle, E.D.; Jones, C.; Whitty, S.

1983-01-01

This paper critically reviews the current methods used for measuring blockage in multi-rod arrays and discusses their application. A new definition which overcomes the deficiencies of the previous methods is proposed. Also examples of the application of automatic computerised techniques to directly measure rod strain, blockage, sub-channel blockage and perimeter changes from photographs of sections through deformed arrays are presented. (author)

Evaluation on Long-term Cooling of CANDU after Sump Blockage using MARS-KS

Energy Technology Data Exchange (ETDEWEB)

Yu, Seon Oh; Cho, Yong Jin [KINS, Daejeon (Korea, Republic of); Kim, Sung Joong [Hanyang University, Seoul (Korea, Republic of)

2016-05-15

There was a real incident that part of the fibrous insulation debris stripped by steam jet was transported to the pool and clogged the intake strainers of the drywell spray system, which revealed a weakness in the defense-in-depth concept which under other circumstances could have led to the ECCS failing to provide coolant to the core. Since the above Barseback-2 incident in 1992, lots of the international activities have been carried out to identify essential parameters and physical phenomena and to promote consensus on the technical issues, important for safety and possible paths for their resolution. In nuclear power plant under operation, if an unplanned reactor trip or a power reduction occurs, operators are required to maintain the reactor in a stable state according to emergency operating procedure (EOP) and to take diagnosis and appropriate mitigation actions if necessary. Subject to the EOP of Wolsong unit 1 (the first Korean PHWR NPP) under LOCA, intact or broken loops are diagnosed using the available plant information such as pressure and temperature of outlet headers. For the intact loop, effective long-term cooling is envisioned through the operation of shutdown cooling system as implemented in the EOP. In this work, the adequacy of long-term cooling during the recirculation phase of LOCA was evaluated under the postulated condition of the reduced flow path of the recirculation sump due to the inflow of substantial amount of debris released by the break flow with high energy. For the intact loop, although the incipience of boiling in the fuel channel was evaluated to occur, the effective long-term cooling can be achieved through the shutdown cooling system as guided in the EOP.

Urine Blockage in Newborns

Science.gov (United States)

... the ureter joins the kidney. Bladder outlet obstruction (BOO). BOO describes any blockage in the urethra or at ... urethral valves (PUV), the most common form of BOO seen in newborns and during prenatal ultrasound exams, ...

Influences of bipolar plate channel blockages on PEM fuel cell performances

International Nuclear Information System (INIS)

Heidary, Hadi; Kermani, Mohammad J.; Dabir, Bahram

2016-01-01

Highlights: • Effect of partial- or full-blockage of PEMFC flow channels is numerically studied. • The anode blockage does not show any positive effects on cell performance. • Full blockages, despite higher pressure drop, better enhance net electrical power. • Additions of blocks more than five do not improve the cell performance. • Full blockage of cathode channels with five blocks enhances the net power by 30%. - Abstract: In this paper, the effect of partial- or full-block placement along the flow channels of PEM fuel cells is numerically studied. Blockage in the channel of flow-field diverts the flow into the gas diffusion layer (GDL) and enhances the mass transport from the channel core part to the catalyst layer, which in turn improves the cell performance. By partial blockage, only a part of the channel flow is shut off. While in full blockage, in which the flow channel cross sections are fully blocked, the only avenue left for the continuation of the gas is to travel over the blocks via the porous zone (GDL). In this study, a 3D numerical model consisting of a 9-layer PEM fuel cell is performed. A wide spectrum of numerical studies is performed to study the influences of the number of blocks, blocks height, and anode/cathode-side flow channel blockage. The results show that the case of full blockage enhances the net electrical power more than that of the partial blockage, in spite of higher pressure drop. Performed studies show that full blockage of the cathode-side flow channels with five blocks along the 5 cm channel enhances the net power by 30%. The present work provides helpful guidelines to bipolar plate manufacturers.

The JAERI code system for evaluation of BWR ECCS performance

International Nuclear Information System (INIS)

Kohsaka, Atsuo; Akimoto, Masayuki; Asahi, Yoshiro; Abe, Kiyoharu; Muramatsu, Ken; Araya, Fumimasa; Sato, Kazuo

1982-12-01

Development of respective computer code system of BWR and PWR for evaluation of ECCS has been conducted since 1973 considering the differences of the reactor cooling system, core structure and ECCS. The first version of the BWR code system, of which developmental work started earlier than that of the PWR, has been completed. The BWR code system is designed to provide computational tools to analyze all phases of LOCAs and to evaluate the performance of the ECCS including an ''Evaluation Model (EM)'' feature in compliance with the requirements of the current Japanese Evaluation Guideline of ECCS. The BWR code system could be used for licensing purpose, i.e. for ECCS performance evaluation or audit calculations to cross-examine the methods and results of applicants or vendors. The BWR code system presented in this report comprises several computer codes, each of which analyzes a particular phase of a LOCA or a system blowdown depending on a range of LOCAs, i.e. large and small breaks in a variety of locations in the reactor system. The system includes ALARM-B1, HYDY-B1 and THYDE-B1 for analysis of the system blowdown for various break sizes, THYDE-B-REFLOOD for analysis of the reflood phase and SCORCH-B2 for the calculation of the fuel assembl hot plane temperature. When the multiple codes are used to analyze a broad range of LOCA as stated above, it is very important to evaluate the adequacy and consistency between the codes used to cover an entire break spectrum. The system consistency together with the system performance are discussed for a large commercial BWR. (author)

Gauging and Etude Radio exposures in Tartous Cement Factory and Naphtha Strainer of Banias

International Nuclear Information System (INIS)

Mala, T.; Soufan, A. A.; Bofroud, T.

2009-01-01

The radio activity level was measured in both Tartous cement factory and naphtha strainer of Banias by using an electronic strumming EPD produced by E urisy F rance company and digelerat-50 strumming produced by C ope E nglish Company. It was [0.090-0.097]μSv/h that is concert with the background level of radioactivity. Some samples were taken from different places at studying areas and the radioactivity was estimated by using Gamma-ray spectroscopy. (author)

Accomplishments of LOCA/ECCS experimental research at Japan Atomic Energy Research Institute

International Nuclear Information System (INIS)

Tasaka, Kanji; Murao, Yoshio; Koizumi, Yasuo

1984-01-01

Japan Atomic Energy Research Institute has investigated loss-of-coolant accident (LOCA)/emergency core cooling system (ECCS) from 1970. Major results of the LOCA/ECCS research are summarized in this report. ROSA-II program was LOCA/ECCS research for a pressurized water reactor (PWR) and ROSA-III program was for a boiling water reactor (BWR). The both test facilities were scaled at approximately 1/400 of the respective reference PWR and BWR. Large scale reflood test is research on reflood phenomena during a large break LOCA of PWR. The test facility is scaled at approximately 1/20 of the reference PWR and the research is still being continued. (author)

Transient response of small molten salt reactor at duct blockage accident

International Nuclear Information System (INIS)

Yamamoto, Takahisa; Mitachi, Koshi; Ikeuchi, Koji; Suzuki, Takashi

2005-01-01

This paper performed transient core analysis of a small Molten Salt Reactor (MSR) at the time of a duct blockage accident. The numerical model employed in this study consists of continuity and momentum conservation equations for fuel salt flow, two group diffusion equations for fast and thermal neutron fluxes, balance equations for six-group delayed neutron precursors and energy conservation equations for fuel salt and graphite moderator. The analysis shows that (1) the effective multiplication factor and reactor power after the blockage accident hardly change because of the self-control performance of the MSR, (2) fuel salt and graphite moderator temperatures rise at the blockage point and its vicinity, drastically but locally, (3) the highest temperature after the blockage accident is 1 363 K, very lower than the boiling point of fuel salt and melt point of reactor vessel, (4) fast and thermal neutron fluxes distributions after the blockage accident hardly change, and (5) delayed neutron precursors accumulate at the blockage point, especially 1st delayed neutron precursor due to is large decay constant. These results lead that the safety of MSR is assured in the blockage accident. (author)

Effects of debris generated by chemical reactions on head loss through emergency-core cooling-system strainers

International Nuclear Information System (INIS)

Howe, K.; Ghosh, A.; Maji, A.K.; Letellier, B.C.; Johns, R.; Chang, T.Y.

2004-01-01

The effect of debris generated during a loss of coolant accident (LOCA) on the emergency core cooling system (ECCS) strainers has been studied via numerous avenues over the last several years. The research described in this manuscript examines the generation and effect of secondary materials -- not debris generated in the LOCA itself, but materials created by chemical reactions between exposed surfaces/debris and cooling system water. The secondary materials studied in the research were corrosion products from exposed metallic surfaces and paint chips that may precipitate out of solution, with a focus on the corrosion products of aluminium, iron, and zinc. The processes of corrosion and leaching of metals with subsequent precipitation is important because: (1) the surface area of exposed metal inside containment represents a large potential source term, even for slow chemical reactions; the chemical composition of the cooling system water (boric acid, lithium, etc.) may affect corrosion or precipitation in ways that have not been studied thoroughly in the past; and (3) an eyewitness report of the presence of gelatinous material in the Three Mile Island containment pool after the 1979 accident suggests the formation of a secondary material that has not been examined under the generic safety issue (GSI)-191 research program. This research was limited in scope and consisted only of small-scale tests. Several key questions were investigated: (1) do credible corrosion mechanisms exist for leaching metal ions from bulk solid surfaces or from zinc-based paint chips, and if so, what are the typical rate constants? (2) can corrosion products accumulate in the containment pool water to the extent that they might precipitate as new chemical species at pH and temperatures levels that are relevant to the LOCA accident sequence? and (3) how do chemical precipitants affect the head loss across an existing fibrous debris bed? A full report of the research is available. (authors)

Application of Interfacial Propagation and Kinking Crack Concept to ECC/Concrete Overlay Repair System

Directory of Open Access Journals (Sweden)

Yaw ChiaHwan

2014-01-01

Full Text Available Research on the application of ultraductile engineered cementitious composite (ECC as overlay in the repair of deteriorated concrete structures is performed in this paper. Also, interfacial crack kinking and trapping mechanism experimentally observed in ECC/concrete overlay repair system are described by comparison of toughness and energy release rate. The mechanism involves cycles of extension, kinking, and arrest of interfacial crack into the overlay. Experimental testing of overlay repair system reveals significant improvements in load carrying capacity and ductility over conventional concrete overlay. The commonly observed overlay system failure mode of delamination or spalling is eliminated when ECC is applied. These failure modes are suppressed when ECC is used as an ideal and durable candidate overlay repair material.

Overcoming Blockages to Collective Innovation in Digital Infrastructures

DEFF Research Database (Denmark)

Rukanova, Boriana; Reuver, Mark; Henningsson, Stefan

2017-01-01

Decentralized digital technologies increasingly enable multiple organizations to co-create digital infrastructures. However, collective innovation processes often come to a stand-still because of conflicting interests and business models. While existing research suggests various factors that block...... collective innovation processes, there is still little understanding of how organizations can overcome these blockages. In this paper, we identify patterns that explain how organizations overcome blockages of collective innovation processes for digital infrastructures. We follow a processual approach...... and develop a conceptual framework based on collective action theory. We evaluate the framework through a longitudinal case study on mobile payment infrastructure development. We find various reconfiguration processes that organizations use to overcome blockages of collective innovation. Theoretically...

Measurement and analysis of the ECC cusp structure

Energy Technology Data Exchange (ETDEWEB)

Pregliasco, R.G.; Garibotti, C.R.; Barrachina, R.O. (Comision Nacional de Energia Atomica, San Carlos de Bariloche (Argentina). Centro Atomico Bariloche)

1994-03-28

We measured the electron capture to the continuum (ECC) peak in the ionization of He atoms by the collision of 50, 100 and 200 keV H[sup +] and 100 keV amu[sup -1]He[sup 2+]. We exhaustively scanned the double differential cross section between the angles -1.5[sup o] to 10[sup o] and within the velocities (1 [+-] 0.15)[upsilon][sub i] where [upsilon][sub i] is the impact velocity. We propose a new method for analysing the ECC structure which is independent of the spectrometer transmission function modellization and enables a direct comparison with the available theories. Furthermore, we distinguish two regimes for the ionization process, depending on whether the electron velocity is larger or smaller than the projectile velocity. (Author).

Physiological blockage in plants in response to postharvest stress

African Journals Online (AJOL)

Marcos

2013-03-13

Mar 13, 2013 ... response of the plant to cut stem (Ichimura et al., 1999). When the vessel is ... blockage due to microbial growth and blockage caused by formation of .... HQS) and chlorine, are used to assess its actions in the microorganisms ...

Noise-based Stego-ECC

Directory of Open Access Journals (Sweden)

Rahardjo Budi

2014-03-01

Full Text Available A novel method of inserting noise into stream of ciphered text is proposed. The goal of inserting noise is to increase the level of uncertainty, thus making it harder for an attacker to detect data and noise. This form of steganography is implemented using Elliptic Curve Cryptography (ECC. The process of embedding the noise to the message in the encryption process and removing the noise from the message in the decryption process is proposed in this work by modifying ElGamal to allow auto detection of data and noise.

Blockage-induced condensation controlled by a local reaction

Science.gov (United States)

Cirillo, Emilio N. M.; Colangeli, Matteo; Muntean, Adrian

2016-10-01

We consider the setup of stationary zero range models and discuss the onset of condensation induced by a local blockage on the lattice. We show that the introduction of a local feedback on the hopping rates allows us to control the particle fraction in the condensed phase. This phenomenon results in a current versus blockage parameter curve characterized by two nonanalyticity points.

A CFD analysis of flow blockage phenomena in ALFRED LFR demo fuel assembly

Energy Technology Data Exchange (ETDEWEB)

Di Piazza, Ivan, E-mail: ivan.dipiazza@enea.it [Italian National Agency for New Technologies, Energy and Sustainable Economic Development, C.R. ENEA Brasimone (Italy); Magugliani, Fabrizio [Ansaldo Nucleare, ANN, Corso Perrone n.25, Genova (Italy); Tarantino, Mariano [Italian National Agency for New Technologies, Energy and Sustainable Economic Development, C.R. ENEA Brasimone (Italy); Alemberti, Alessandro [Ansaldo Nucleare, ANN, Corso Perrone n.25, Genova (Italy)

2014-09-15

Highlights: • URANS simulations were performed on internal flow blockage in HLM fuel assemblies. • Comparison with RELAP results for foot blockage shows a very good agreement. • The temperature peak behind the blockage is dominant for large blockages. • A blockage of ∼15% leads to a maximum clad temperature around 800 °C in 3–4 s. • Local clad temperatures around 1000 °C are reached for blockages of 30% or more. - Abstract: A CFD study was carried out on fluid flow and heat transfer in the Lead-cooled Fuel Pin Bundle of the ALFRED LFR DEMO. In the context of GEN-IV heavy liquid metal-cooled reactors safety studies, the flow blockage in a fuel sub-assembly is considered one of the main issues to be addressed and the most important and realistic accident for LFR fuel assembly. The present paper is a first step toward a detailed analysis of such phenomena, and a CFD model and approach are presented to have a detailed thermo-fluid dynamic picture in the case of blockage. In particular the closed hexagonal, grid-spaced fuel assembly of the LFR ALFRED was modeled and computed. At this stage, the details of the spacer grids were not included, but a conservative analysis has been carried out based on the current main geometrical and physical features. Reactivity feedback, as well as axial power profile, were not included in this analysis. Results indicate that critical conditions, with clad temperatures around ∼900 °C, are reached with blockage larger than 30% in terms of area fraction. Two main effects can be distinguished: a local effect in the wake/recirculation region downstream the blockage and a global effect due to the lower mass flow rate in the blocked subchannels; the former effect gives rise to a temperature peak behind the blockage and it is dominant for large blockages (>20%), while the latter effect determines a temperature peak at the end of the active region and it is dominant for small blockages (<10%). The blockage area was placed at

Quorum sensing in the plant pathogen Erwinia carotovora subsp. carotovora: the role of expR(Ecc).

Science.gov (United States)

Andersson, R A; Eriksson, A R; Heikinheimo, R; Mäe, A; Pirhonen, M; Kõiv, V; Hyytiäinen, H; Tuikkala, A; Palva, E T

2000-04-01

The production of the main virulence determinants of the plant pathogen Erwinia carotovora subsp. carotovora, the extracellular cell wall-degrading enzymes, is partly controlled by the diffusible signal molecule N-(3-oxohexanoyl)-L-homoserine lactone (OHHL). OHHL is synthesized by the product of the expI/carI gene. Linked to expI we found a gene encoding a putative transcriptional regulator of the LuxR-family. This gene, expR(Ecc), is transcribed convergently to the expI gene and the two open reading frames are partially overlapping. The ExpR(Ecc) protein showed extensive amino acid sequence similarity to the repressor EsaR from Pantoea stewartii subsp. stewartii (formerly Erwinia stewartii subsp. stewartii) and to the ExpR(Ech) protein of Erwinia chrysanthemi. Inactivation of the E. carotovora subsp. carotovora expR(Ecc) gene caused no decrease in virulence or production of virulence determinants in vitro. In contrast, there was a slight increase in the maceration capacity of the mutant strain. The effects of ExpR(Ecc) were probably mediated by changes in OHHL levels. Inactivation of expR(Ecc) resulted in increased OHHL levels during early logarithmic growth. In addition, overexpression of expR(Ecc) caused a clear decrease in the production of virulence determinants and part of this effect was likely to be caused by OHHL binding to ExpR(Ecc). ExpR(Ecc) did not appear to exhibit transcriptional regulation of expI, but the effect on OHHL was apparently due to other mechanisms.

Application of Engineered Cementitious Composites (ECC) in modular floor panels

DEFF Research Database (Denmark)

Lárusson, Lárus Helgi; Fischer, Gregor; Jönsson, Jeppe

2008-01-01

This paper describes the design, manufacturing, and structural behavior of a prefabricated floor panel consisting of a modular assembly of a thin-walled ECC slab and steel truss girders. The features of this composite structure include light weight, the modular manufacturing process...... concept introduced in this paper aims at improvements in the manufacturing process of the panels by casting the ECC slab separately and subsequently joining it with the steel trusses. The focus of this paper is on design and manufacturing of a prototype modular panel and on its structural behavior under...

On the energy shift the ECC cusp. Does the shift really exist?

International Nuclear Information System (INIS)

Sarkadi, L.; Barrachina, R.O.

2004-01-01

The cusplike 'electron capture to the continuum' (ECC) peak appearing in the spectrum of the forward emitted electrons in ion-atom collisions are generally thought to be a divergence. Recently Shah et al., however, claimed that 'the ECC cusp is indeed a cusp, and not a divergence smoothed by the experiment'. These authors measured the ECC cusp for collisions of 10- and 20-keV protons with H 2 and He, and found that the peak was shifted to lower velocity than its expected position. We also carried out CTMC calculations (for the case of 20-keV protons on He) by which we demonstrated that the shift really exists but its value depends on the angular window of the electron detection. (K.A.)

FLECHT-SEASET 21-rod bundle flow blockage heat transfer during reflood

International Nuclear Information System (INIS)

Loftus, M.; Hochreiter, L.; Lee, N.

1983-01-01

The effect of various flow blockage shapes and distributions during a PWR reflood was investigated using six 21-rod bundles with full length, internally heated, cosine power-shaped electrical rods. The flow blockage shapes, simulating the fuel rod clad ballooning, were made of thin-wall stainless steel tubes hydroformed into a short, concentric shape and along, nonconcentric shape. The blockage sleeves were distributed both coplanar, with all sleeves located at the same elevation, and non-coplanar. The initial and boundary conditions were varied to include parametric effects of pressure, inlet water temperature, and primarily, flooding rate. The initial mid-plane rod temperature was 871 0 C (1600 0 F) in all tests. Rod and vapor temperature measurements were made throughout the rod bundle with emphasis on the blockage region. The rod heat transfer downstream of the blockage was found to be greater for rods in a blocked bundle than for similar rods in an unblocked bundle. The heat transfer improvement decreases both with time after flood initiation and as the distance increased downstream of the blockage. The improvement in the heat transfer is attributed primarily to the breakup of the water droplets entrained in the steam flow. The smaller droplets subsequently evaporate and desuperheat the steam, which then improves the heat transfer between the rods and the steam in and downstream of the blockage zone

Historical information on ORNL proposals for ECCS testing

International Nuclear Information System (INIS)

1976-01-01

This document contains a compilation of the correspondence and preliminary report which the Oak Ridge National Laboratory submitted to the U.S. Atomic Energy Commission on the subject of in situ testing of emergency core cooling systems (ECCS) in pressurized water reactors. Most of the correspondence, which was prepared four to five years ago, deals with an ORNL proposal to evaluate the merits of conducting an in situ ECCS test in a full-scale commercial power plant. The end result of this work was to be a report in which the feasibility of conducting such an experiment would be discussed and a ''rough'' cost estimate provided. In support of this proposal, ORNL prepared a brief preliminary prospectus which identified some of the key questions that were to be addressed should the evaluation study be funded

Investigation of Characteristics of Impinging Jet for 1/5-Scale ECC injection

Energy Technology Data Exchange (ETDEWEB)

Shin, Byung Soo; Ko, Yung Joo; Bae, Hwang; Kwon, Tae Soon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2010-05-15

In ECCS of SMART reactor, safety injection pump discharges cooling water into the core to maintain the water level by filling the amount of loss of coolant under emergency situation such as SBLOCA. Once the ECCS starts to operate, the injected water will be impinged to the upper wall of core support barrel (CBS). And the water will fall along the wall forming liquid film or droplets as shown in Fig. 1(b) due to high Reynolds number. The breakup and film flow will be bypassed by high temperature and pressure steam-water mixture cross flow from RCP discharge into the atmosphere through broken injection nozzle. Then, the flow phenomena in the downcomer is very complex situation with including jet impingement, jet breakup, liquid entrainment, steam condensation, counter-current flow and etc. In this study, the hydraulic features of impinging jet were investigated through visualization for full scale test for simulation of SMART ECC jet and SWAT test of 1/5 simulated test for ECCS of SMART reactor and measurement of the film width. And the scaling method for SWAT test was discussed considering jet break up and other phenomena

ECC2K-130 on NVIDIA GPUs

NARCIS (Netherlands)

Bernstein, D.J.; Chen, H.-C.; Cheng, C.M.; Lange, T.; Niederhagen, R.F.; Schwabe, P.; Yang, B.Y.

2012-01-01

[Updated version of paper at Indocrypt 2010] A major cryptanalytic computation is currently underway on multiple platforms, including standard CPUs, FPGAs, PlayStations and GPUs, to break the Certicom ECC2K-130 challenge. This challenge is to compute an elliptic-curve discrete logarithm on a Koblitz

ECC2K-130 on NVIDIA GPUs

NARCIS (Netherlands)

Bernstein, D.J.; Chen, H.-C.; Cheng, C.M.; Lange, T.; Niederhagen, R.F.; Schwabe, P.; Yang, B.Y.; Gong, G.; Gupta, K.C.

2010-01-01

A major cryptanalytic computation is currently underway on multiple platforms, including standard CPUs, FPGAs, PlayStations and Graphics Processing Units (GPUs), to break the Certicom ECC2K-130 challenge. This challenge is to compute an elliptic-curve discrete logarithm on a Koblitz curve over $\\rm

Reflooding experiments on a 49-rod cluster containing a long 90% blockage

International Nuclear Information System (INIS)

Pearson, K.G.; Cooper, C.A.; Jowitt, D.; Kinneir, J.H.

1983-01-01

A series of reflooding experiments was performed on a model fuel assembly, containing a very severe partial blockage, in the THETIS rig. The assembly comprised 49 full length, electrically heated fuel rod simulators and the blockage was created by attaching thin-walled, preformed swellings to a group of 16 rods. Results are presented for single phase and forced reflooding experiments. The most important findings relate to the improvements in heat transfer created by spacer grids and the nature of the heat transfer processes within the blockage. Spacer grids are shown to improve heat transfer by increasing turbulence and also, when wet, by cooling the steam flowing through them. Liquid penetration evidently deteriorates as the rewetting front approaches the blockage, allowing the steam through the blockage to superheat strongly and giving rise to a late peak in cladding temperature. At low reflooding rates there is a temperature penalty associated with the blockage which becomes increasingly larger as the reflooding rate is reduced. The adequacy of cooling in this very severe blockage becomes questionable when the reflooding rate falls to about 2cm/s. (U.K.)

Direct ECC bypass phenomena in the MIDAS test facility during LBLOCA reflood phase

International Nuclear Information System (INIS)

Yun, B. J.; Kweon, T. S.; Ah, D. J.; Ju, I. C.; Song, C. H.; Park, J. K.

2001-01-01

This paper describes the experimental results of ECC Direct Bypass Phenomena in the downcomer during the late reflood phase of LBLOCA of the reactor that adopts Direct Vessel Injection as a ECC system. The experiments have been performed in MIDAS test facility using superheated steam and water. The test condition was determined, based on the preliminary analysis of TRAC code, from modified linear scaling method of 1/4.93 length scale. To measure the direct bypass fraction according to the nozzle location, separate effect tests have been performed in case of DVI-4(farthest from broken cold leg) injection, DVI-2(closest to broken cold leg) injection, and DVI-2 and 4 injection, respectively. Also the test was carried out varying the steam flow rate greatly to investigate the effect of steam flow rate on the direct bypass fraction of ECC water. Test results show that the direct bypass fraction of ECC water depends significantly on the injected steam mass flow rate. DVI-4 tests show that the direct bypass fraction increases drastically as the steam flow rate increases. However, in DVI-2 test most of the injected ECC water penetrates into lower downcomer. The direct bypass characteristic in each of DVI-2 and DVI-4 tests is reflected into the direct bypass characteristic curve of DVI-2 and 4 test. The steam condensation reaches to the theoretically allowable maximum value

An Experimental Evaluation of Blockage Corrections for Current Turbines

Science.gov (United States)

Ross, Hannah; Polagye, Brian

2017-11-01

Flow confinement has been shown to significantly alter the performance of turbines that extract power from water currents. These performance effects are related to the degree of constraint, defined by the ratio of turbine projected area to channel cross-sectional area. This quantity is referred to as the blockage ratio. Because it is often desirable to adjust experimental observations in water channels to unconfined conditions, analytical corrections for both wind and current turbines have been derived. These are generally based on linear momentum actuator disk theory but have been applied to turbines without experimental validation. This work tests multiple blockage corrections on performance and thrust data from a cross-flow turbine and porous plates (experimental analogues to actuator disks) collected in laboratory flumes at blockage ratios ranging between 10 and 35%. To isolate the effects of blockage, the Reynolds number, Froude number, and submergence depth were held constant while the channel width was varied. Corrected performance data are compared to performance in a towing tank at a blockage ratio of less than 5%. In addition to examining the accuracy of each correction, underlying assumptions are assessed to determine why some corrections perform better than others. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1256082 and the Naval Facilities Engineering Command (NAVFAC).

Blockage effects on the hydrodynamic performance of a marine cross-flow turbine.

Science.gov (United States)

Consul, Claudio A; Willden, Richard H J; McIntosh, Simon C

2013-02-28

This paper explores the influence of blockage and free-surface deformation on the hydrodynamic performance of a generic marine cross-flow turbine. Flows through a three-bladed turbine with solidity 0.125 are simulated at field-test blade Reynolds numbers, O(10(5)-10(6)), for three different cross-stream blockages: 12.5, 25 and 50 per cent. Two representations of the free-surface boundary are considered: rigid lid and deformable free surface. Increasing the blockage is observed to lead to substantial increases in the power coefficient; the highest power coefficient computed is 1.23. Only small differences are observed between the two free-surface representations, with the deforming free-surface turbine out-performing the rigid lid turbine by 6.7 per cent in power at the highest blockage considered. This difference is attributed to the increase in effective blockage owing to the deformation of the free surface. Hydrodynamic efficiency, the ratio of useful power generated to overall power removed from the flow, is found to increase with blockage, which is consistent with the presence of a higher flow velocity through the core of the turbine at higher blockage ratios. Froude number is found to have little effect on thrust and power coefficients, but significant influence on surface elevation drop across the turbine.

Preparation and evaluation of 68Ga-ECC as a PET renal imaging agent

International Nuclear Information System (INIS)

Mizaei, Alireza; Jaililan, Amir Reza; Mazidi, Mohammad; Aghanejad, Ayuob; Yousefnia, Hassan; Shabani, Gholamli; Ardaneh, Khosro; Geramifar, Patham; Beiki, Davood

2015-01-01

Development of a gallium-68-labeled renal tracer can be a good substitute for Tc-99m, a known SPECT tracer. In this study, effort was made to develop 68 Ga-ethylenecysteamine cysteine ( 68 Ga-ECC). Ga-ECC was prepared using generator-based 68 GaCl3 and ethylenecysteamine cysteine (ECC) at optimized conditions. Stability of the complex was checked in human serum followed by partition coefficient determination of the tracer. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 120 min. Ga-ECC was prepared at optimized conditions in 15 min at 90 °C (radiochemical purity ≈97 ± 0.88 % ITLC, >99 % HPLC, specific activity: 210 ± 5 GBq/mM). 68 Ga-ECC was a water-soluble complex based on partition coefficient data (log P; −1.378) and was stable in the presence of human serum for 2 h at 37 °C. The biodistribution of the tracer demonstrated high kidney excretion of the tracer in 10–20 min. The SUV max ratios of the liver to left kidney were 0.38 and 0.39 for 30 and 90 min, respectively, indicating high kidney uptake. Initial biodistribution results showed significant kidney and urinary excretion of the tracer comparable to that of the homologous 99m Tc compound. The complex could be a possible PET kidney imaging agent with a fast imaging time

Lightweight ECC based RFID authentication integrated with an ID verifier transfer protocol.

Science.gov (United States)

He, Debiao; Kumar, Neeraj; Chilamkurti, Naveen; Lee, Jong-Hyouk

2014-10-01

The radio frequency identification (RFID) technology has been widely adopted and being deployed as a dominant identification technology in a health care domain such as medical information authentication, patient tracking, blood transfusion medicine, etc. With more and more stringent security and privacy requirements to RFID based authentication schemes, elliptic curve cryptography (ECC) based RFID authentication schemes have been proposed to meet the requirements. However, many recently published ECC based RFID authentication schemes have serious security weaknesses. In this paper, we propose a new ECC based RFID authentication integrated with an ID verifier transfer protocol that overcomes the weaknesses of the existing schemes. A comprehensive security analysis has been conducted to show strong security properties that are provided from the proposed authentication scheme. Moreover, the performance of the proposed authentication scheme is analyzed in terms of computational cost, communicational cost, and storage requirement.

Thermohydraulic and thermal stress aspects of a porous blockage in an LMFBR fuel assembly

International Nuclear Information System (INIS)

Kuzay, T.M.; Marr, W.W.; Helenberg, H.W.; Ariman, T.; Wilson, R.E.; Pedersen, D.R.

1979-01-01

The current safety scenarios of Liquid Metal Fast Breeder Reactors (LMFBR) under local fault propagation include the study of a hypothetical accident initiated by the formation of an external debris porous blockage in a fuel subassembly. In this preliminary experimental and analytical investigation, a non-heat-generating porous blockage was postulated to cover 18 flow channels of a 37 pin Fast Test Reactor (FTR) type fuel subassembly. The axial extent of the blockage is 50 mm. The blockage material is stainless steel (SS 316) with 30 percent average porosity (percent void volume). The blockage and the pins were modeled with a finite element technique and the thermal field in the blockage was predicted. This thermal field was utilized to do a planar thermal stress analysis of the postulated blockage. To verify the analytical model and also to better understand the thermal-hydraulics of such a porous blockage out-of-pile tests were conducted in a sodium loop. Data from the out-of-pile tests was utilized to calibrate and improve the analytical model

An adapted blockage factor correlation approach in wind tunnel experiments of a Savonius-style wind turbine

International Nuclear Information System (INIS)

Roy, Sukanta; Saha, Ujjwal K.

2014-01-01

Highlights: • Significance of the blockage correction in wind tunnel experiments of Savonius-style wind turbine. • Adaptation of blockage factor correlations under open type test sections for blockage ratio of 21.16%. • Effectiveness of adapted correlations for smaller blockage ratios (BRs) of 16% and 12.25%. • Estimate the magnitude of the blockage correction under various loading conditions for each BR. • Variation of blockage correction factor with respect to tip speed ratio and BR. - Abstract: An investigation into the blockage correction effects in wind tunnel experiments of a small-scale wind energy conversion system in an open type test section is carried out. The energy conversion system includes a Savonius-style wind turbine (SSWT) and a power measurement assembly. As the available correlations for the closed type test sections may not be appropriate for the open test section under dynamic loading conditions, new correlations are adapted for the blockage correction factors with free stream wind speed, turbine rotational speed and variable load applied to the turbine to quantify the energy conversion coefficients more precisely. These are obtained for a blockage ratio of 21.16% through a comparison of present experimental data with those of established experimental data under dynamic loading conditions. Further, the accuracy of the adapted correlations is substantiated into the experiments with smaller blockage ratios of 16% and 12.25%. The relationships of the tip speed ratios and blockage ratios with the blockage correction factor are also discussed. Using these correlations, this study provides evidence of increase of blockage correction in the range 1–10% with the increase of both tip speed ratio and blockage ratio. The results also indicate that for blockage ratios approaching 10 and tip speed ratios below 0.5, the blockage effects are almost negligible in the open type test sections

Gonioscopic changes in conventional ECCE vs manual SICS: A comparative study

Directory of Open Access Journals (Sweden)

Surya Joseph, Sundararajan D, Rajvin Samuel Ponraj, Srinivasan M, Veluchamy

2014-04-01

Full Text Available The aim of the study is to observe and compare the Gonioscopic changes in the angle of the anterior chamber of the eye after surgeries namely; Conventional Extra capsular cataract extraction (ECCE with Posterior chamber Intraocular lens (PC IOL implantation, Manual Small incision Cataract Surgery with PCIOL implantation. The clinical study was undertaken after Institutional Ethical committee clearance, securing the inform consent, total number of 100 patients were enrolled in the study. 50 ECCE; 50 SICS consisting of 57 Males and 43 Females aged between 40 – 80yrs who were admitted and operated for Cataract at Meenakshi Medical college Hospital & Research institute. The following parameters are studied: Gonioscopic changes in the angle, namely the PAS formation in the quadrants, pigment dispersion in each of the methods. After this study, we arrive to a conclusion that complications in the angle of anterior chamber occur mostly in Conventional with insignificant change in manual SICS. So manual Small incision Cataract Surgery with PCIOL implantation is preferable over Conventional ECCE with PCIOL implantation.

LOFT ECC Pitot Tube and Thermocouple Rake Penetration thermal analysis

International Nuclear Information System (INIS)

Tolan, B.J.

1977-01-01

A thermal analysis of the LOFT ECC Pitot Tube and Thermocouple Rake Penetration was performed using COUPLE, a two-dimensional finite element computer code. Four transients which conservatively cover all transients the rake will be exposed to were included in this analysis in order to comply with the ASME Code Section III requirements. The transients conservatively cover hot and cold leg operation, and nuclear and nonnuclear operation. The four transients include the LOCE with ECC injection transient, the single control rod drop transient, the scram transient, and the heatup with 0 to 100% load change transient. Temperature distributions in the rake were obtained for each of the four transients and several plots of node temperatures vs. time are given

Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks

Science.gov (United States)

Belotserkovskii, Boris P.; Neil, Alexander J.; Saleh, Syed Shayon; Shin, Jane Hae Soo; Mirkin, Sergei M.; Hanawalt, Philip C.

2013-01-01

The ability of DNA to adopt non-canonical structures can affect transcription and has broad implications for genome functioning. We have recently reported that guanine-rich (G-rich) homopurine-homopyrimidine sequences cause significant blockage of transcription in vitro in a strictly orientation-dependent manner: when the G-rich strand serves as the non-template strand [Belotserkovskii et al. (2010) Mechanisms and implications of transcription blockage by guanine-rich DNA sequences., Proc. Natl Acad. Sci. USA, 107, 12816–12821]. We have now systematically studied the effect of the sequence composition and single-stranded breaks on this blockage. Although substitution of guanine by any other base reduced the blockage, cytosine and thymine reduced the blockage more significantly than adenine substitutions, affirming the importance of both G-richness and the homopurine-homopyrimidine character of the sequence for this effect. A single-strand break in the non-template strand adjacent to the G-rich stretch dramatically increased the blockage. Breaks in the non-template strand result in much weaker blockage signals extending downstream from the break even in the absence of the G-rich stretch. Our combined data support the notion that transcription blockage at homopurine-homopyrimidine sequences is caused by R-loop formation. PMID:23275544

A study of ECC water bypass reduction technology for an improvement of core cooling capability

International Nuclear Information System (INIS)

Song, C. G.; Kwon, T. S.; Yun, B. J.

2006-02-01

The research for the reduction of ECC water bypass fraction was mainly performed to develop the flow mechanisms that ECC water can penetrate more effectively into a lower downcomer. Evaluation were carried out for the effect of major parameters on the bypass of ECC water in the downcomer with DVI. The following various physical models were derived for the reduction of the bypass fraction of ECC water: models of changing DVI injection angle, models of rearranging relative angles of DVI nozzles, model of grooved-and-subchannel type core barrel, model of dual core barrel. CFD analysis and MARS design verification were performed for the derived models as a first step performance estimation. Through out air-water verification experiments, quantitative evaluation were performed for each model, and three most efficient models were suggested. Examination were carried out for the requirement of structural modification and the change in structural integrity due to the adoption of one of the schemes

Preparation and evaluation of {sup 68}Ga-ECC as a PET renal imaging agent

Energy Technology Data Exchange (ETDEWEB)

Mizaei, Alireza; Jaililan, Amir Reza; Mazidi, Mohammad; Aghanejad, Ayuob; Yousefnia, Hassan; Shabani, Gholamli; Ardaneh, Khosro [Radiation Application Research School, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of); Geramifar, Patham; Beiki, Davood [Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran (Iran, Islamic Republic of)

2015-09-15

Development of a gallium-68-labeled renal tracer can be a good substitute for Tc-99m, a known SPECT tracer. In this study, effort was made to develop {sup 68}Ga-ethylenecysteamine cysteine ({sup 68}Ga-ECC). Ga-ECC was prepared using generator-based {sup 68}GaCl3 and ethylenecysteamine cysteine (ECC) at optimized conditions. Stability of the complex was checked in human serum followed by partition coefficient determination of the tracer. The biodistribution of the tracer in rats was studied using tissue counting and PET/CT imaging up to 120 min. Ga-ECC was prepared at optimized conditions in 15 min at 90 °C (radiochemical purity ≈97 ± 0.88 % ITLC, >99 % HPLC, specific activity: 210 ± 5 GBq/mM). {sup 68}Ga-ECC was a water-soluble complex based on partition coefficient data (log P; −1.378) and was stable in the presence of human serum for 2 h at 37 °C. The biodistribution of the tracer demonstrated high kidney excretion of the tracer in 10–20 min. The SUV{sub max} ratios of the liver to left kidney were 0.38 and 0.39 for 30 and 90 min, respectively, indicating high kidney uptake. Initial biodistribution results showed significant kidney and urinary excretion of the tracer comparable to that of the homologous {sup 99m}Tc compound. The complex could be a possible PET kidney imaging agent with a fast imaging time.

Multi-dimensional analysis of the ECC behavior in the UPI plant Kori Unit 1

International Nuclear Information System (INIS)

Bae, Sungwon; Chung, Bub-Dong; Bang, Young Seok

2008-01-01

A multi-dimensional transient analysis during the LBLOCA of the Kori Unit 1 has been performed by using the MARS code. Based on 1-D nodalization of the Kori Unit 1, the reactor vessel nodalizations have been replaced by the multi-dimensional component. The multi-dimensional component for the reactor vessel is designed as 5 radial, 8 peripheral, and 21 vertical grids. It is assumed that the fuel assemblies are homogeneously distributed in inner 3 radial grids. The outer 1 radial grid region is modeled as the core bypass. The outer-model 1 radial grid is used for the downcomer region. The corresponding heat structures and fuels are modified to fit for the multi-dimensional reactor vessel model. The form drag coefficients for the upper plenum and the core have been designated as 0.6 and 9.39, respectively. The form drag coefficients for the radial and peripheral directions are assigned to the same on the assumption of homogeneous distribution of the flow obstacles. After obtaining the 102% power steady operation condition, cold leg LOCA simulation is performed during 400 second period. The multi-dimensional steady run results show no severe differences compared to the traditional 1-D nodalization results. After the ECC injection starts, a liquid pool is maintained at the upper plenum because the ECCS water can not overcome the upward gas flow that comes from the reactor core through the upper tie plate. The depth of ECCS water pool is predicted as about 20% of the total height from the upper tie plate and the center line of the hot leg pipe. At the vicinity region of the active ECCS show higher depth of liquid pool. The accumulated water flow rate passing the upper tie plate is calculated by the transient result. Much downward water flow is obtained at the outer-most region of upper plenum space. The downward flow dominant region is about 32.3% of the total upper tie plate area. The accumulated ECCS bypass ratio is predicted as 27.64% at 300 second. It is calculated

Experiments on injection performance of SMART ECC facility using SWAT

Energy Technology Data Exchange (ETDEWEB)

Cho, Young Il; Cho, Seok; Ko, Yung Joo; Min, Kyoung Ho; Shin, Yong Cheol; Kwon, Tae Soon; Yi, Sung Jae; Lee, Won Jae [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2012-05-15

SMART (System-integrated Modular Advanced ReacTor), an advanced integrated PWR is now in the under developing stages by KAERI. Such integral PWR excludes large-size piping of the primary system of conventional PWR and incorporates the SGs into RPV, which means no LBLOCA could occur in SMART. Therefore, the SBLOCA is considered as a major DBA (Design Basis Accident) in SMART and it is mainly analyzed by using TASS/SMR computer code. The TASS/SMR code should be validated using experimental data from both Integral Effect Test and Separate Effect Test facilities. To investigate injection performance of the ECC system, on SET facility, named as SWAT (SMART ECC Water Asymmetric Two-phase choking test facility), has been constructed at KAERI. The SWAT simulates the geometric configurations of the SG-side upper downcomer annulus and ECCSs of those of SMART. It is designed based on the modified linear scaling method with a scaling ratio of 1/5, to preserve the geometrical similarity and minimize gravitational distortion. The purpose of the SWAT tests is to investigate the safety injection performance, such as the ECC bypass in the downcomer and the penetration rate in the core during the SBLOCA, and hence to produce experimental data to validate and the prediction capability of safety analysis codes, TASS/SMR

Reassessment of debris ingestion effects on emergency core cooling-system pump performance

International Nuclear Information System (INIS)

Sciacca, F.W.; Rao, D.V.

2004-01-01

A study sponsored by the United States (US) Nuclear Regulatory Commission (NRC) was performed to reassess the effects of ingesting loss of coolant accident (LOCA) generated materials into emergency core cooling system (ECCS) pumps and the subsequent impact of this debris on the pumps' ability to provide long-term cooling to the reactor core. ECCS intake systems have been designed to screen out large post-LOCA debris materials. However, small-sized debris can penetrate these intake strainers or screens and reach critical pump components. Prior NRC-sponsored evaluations of possible debris and gas ingestion into ECCS pumps and attendant impacts on pump performance were performed in the early 1980's. The earlier study focused primarily on pressurised water reactor (PWR) ECCS pumps. This issue was revisited both to factor in our improved knowledge of LOCA generated debris and to address specifically both boiling water reactor (BWR) and PWR ECCS pumps. This study discusses the potential effects of ingested debris on pump seals, bearing assemblies, cyclone debris separators, and seal cooling water subsystems. This assessment included both near-term (less than one hour) and long-term (greater than one hour) effects introduced by the postulated LOCA. The work reported herein was performed during 1996-1997. (authors)

CFD analysis of blockage length on a partially blocked fuel rod

International Nuclear Information System (INIS)

Scuro, Nikolas Lymberis; Andrade, Delvonei Alves de; Angelo, Gabriel; Angelo, Edvaldo

2017-01-01

In LOCA accidents, fuel rods may balloon by the increasing of pressure difference between fuel rod and core vessel. With the balloon effect, the swelling can partially block the flow channel, affecting the coolability during reflood phase. In order to analyze the influence of blockage length after LOCA events, many numerical simulations using Ansys-CFX code have been done in steady state condition, characterizing the final phase of reflood. Peaks of temperature are observed in the middle of the fuel rod, followed by a temperature drop. This effect is justified by the increasing of heat transfer coefficient, originated from the high turbulence effects. Therefore, this paper considers a radial blockage of 90%, varying just the blockage length. This study observed that, for the same boundary conditions, the longer the blockage length originated after LOCA events, the higher are the central temperatures in the fuel rod. (author)

CFD analysis of blockage length on a partially blocked fuel rod

Energy Technology Data Exchange (ETDEWEB)

Scuro, Nikolas Lymberis; Andrade, Delvonei Alves de [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Engenharia Nuclear; Angelo, Gabriel [Centro Universitário FEI (UNIFEI), São Paulo, SP (Brazil). Dept. de Engenharia Mecânica; Angelo, Edvaldo, E-mail: nikolas.scuro@gmail.com, E-mail: delvonei@ipen.br, E-mail: gangelo@fei.edu.br, E-mail: eangelo@mackenzie.br [Universidade Presbiteriana Mackenzie, São Paulo, SP (Brazil). Escola da Engenharia. Grupo de Simulação Numérica

2017-07-01

In LOCA accidents, fuel rods may balloon by the increasing of pressure difference between fuel rod and core vessel. With the balloon effect, the swelling can partially block the flow channel, affecting the coolability during reflood phase. In order to analyze the influence of blockage length after LOCA events, many numerical simulations using Ansys-CFX code have been done in steady state condition, characterizing the final phase of reflood. Peaks of temperature are observed in the middle of the fuel rod, followed by a temperature drop. This effect is justified by the increasing of heat transfer coefficient, originated from the high turbulence effects. Therefore, this paper considers a radial blockage of 90%, varying just the blockage length. This study observed that, for the same boundary conditions, the longer the blockage length originated after LOCA events, the higher are the central temperatures in the fuel rod. (author)

Intricate and Cell Type-Specific Populations of Endogenous Circular DNA (eccDNA) in Caenorhabditis elegans and Homo sapiens.

Science.gov (United States)

Shoura, Massa J; Gabdank, Idan; Hansen, Loren; Merker, Jason; Gotlib, Jason; Levene, Stephen D; Fire, Andrew Z

2017-10-05

Investigations aimed at defining the 3D configuration of eukaryotic chromosomes have consistently encountered an endogenous population of chromosome-derived circular genomic DNA, referred to as extrachromosomal circular DNA (eccDNA). While the production, distribution, and activities of eccDNAs remain understudied, eccDNA formation from specific regions of the linear genome has profound consequences on the regulatory and coding capabilities for these regions. Here, we define eccDNA distributions in Caenorhabditis elegans and in three human cell types, utilizing a set of DNA topology-dependent approaches for enrichment and characterization. The use of parallel biophysical, enzymatic, and informatic approaches provides a comprehensive profiling of eccDNA robust to isolation and analysis methodology. Results in human and nematode systems provide quantitative analysis of the eccDNA loci at both unique and repetitive regions. Our studies converge on and support a consistent picture, in which endogenous genomic DNA circles are present in normal physiological states, and in which the circles come from both coding and noncoding genomic regions. Prominent among the coding regions generating DNA circles are several genes known to produce a diversity of protein isoforms, with mucin proteins and titin as specific examples. Copyright © 2017 Shoura et al.

Fuel temperature analysis method for channel-blockage accident in HTTR

International Nuclear Information System (INIS)

Maruyama, So; Fujimoto, Nozomu; Sudo, Yukio; Kiso, Yoshihiro; Hayakawa, Hitoshi

1994-01-01

During operation of the High Temperature Engineering Test Reactor (HTTR), coolability must be maintained without core damage under all postulated accident conditions. Channel blockage of a fuel element was selected as one of the design-basis accidents in the safety evaluation of the reactor. The maximum fuel temperature for such a scenario has been evaluated in the safety analysis and is compared to the core damage limits.For the design of the HTTR, an in-core thermal and hydraulic analysis code ppercase[flownet/trump] was developed. This code calculates fuel temperature distribution, not only for a channel blockage accident but also for transient conditions. The validation of ppercase[flownet/trump] code was made by comparison of the analytical results with the results of thermal and hydraulic tests by the Helium Engineering Demonstration Loop (HENDEL) multi-channel test rig (T 1-M ), which simulated one fuel column in the core. The analytical results agreed well with the experiments in which the HTTR operating conditions were simulated.The maximum fuel temperature during a channel blockage accident is 1653 C. Therefore, it is confirmed that the integrity of the core is maintained during a channel blockage accident. ((orig.))

A Secure-Enhanced Data Aggregation Based on ECC in Wireless Sensor Networks

Directory of Open Access Journals (Sweden)

Qiang Zhou

2014-04-01

Full Text Available Data aggregation is an important technique for reducing the energy consumption of sensor nodes in wireless sensor networks (WSNs. However, compromised aggregators may forge false values as the aggregated results of their child nodes in order to conduct stealthy attacks or steal other nodes’ privacy. This paper proposes a Secure-Enhanced Data Aggregation based on Elliptic Curve Cryptography (SEDA-ECC. The design of SEDA-ECC is based on the principles of privacy homomorphic encryption (PH and divide-and-conquer. An aggregation tree disjoint method is first adopted to divide the tree into three subtrees of similar sizes, and a PH-based aggregation is performed in each subtree to generate an aggregated subtree result. Then the forged result can be identified by the base station (BS by comparing the aggregated count value. Finally, the aggregated result can be calculated by the BS according to the remaining results that have not been forged. Extensive analysis and simulations show that SEDA-ECC can achieve the highest security level on the aggregated result with appropriate energy consumption compared with other asymmetric schemes.

Complete Flow Blockage of a Fuel Channel for Research Reactor

International Nuclear Information System (INIS)

Lee, Byeonghee; Park, Suki

2015-01-01

The CHF correlation suitable for narrow rectangular channels are implemented in RELAP5/MOD3.3 code for the analyses, and the behavior of fuel temperatures and MCHFR(minimum critical heat flux ratio) are compared between the original and modified codes. The complete flow blockage of fuel channel for research reactor is analyzed using original and modified RELAP5/MOD3.3 and the results are compared each other. The Sudo-Kaminaga CHF correlation is implemented into RELAP5/MOD3.3 for analyzing the behavior of fuel adjacent to the blocked channel. A flow blockage of fuel channels can be postulated by a foreign object blocking cooling channels of fuels. Since a research reactor with plate type fuel has isolated fuel channels, a complete flow blockage of one fuel channel can cause a failure of adjacent fuel plates by the loss of cooling capability. Although research reactor systems are designed to prevent foreign materials from entering into the core, partial flow blockage accidents and following fuel failures are reported in some old research reactors. In this report, an analysis of complete flow blockage accident is presented for a 15MW pool-type research reactor with plate type fuels. The fuel surface experience different heat transfer regime in the results from original and modified RELAP5/MOD3.3. By the discrepancy in heat transfer mode of two cases, a fuel melting is expected by the modified RELAP5/MOD3.3, whereas the fuel integrity is ensured by the original code

The Heat Exchanger for Passive Part ECCS of WWER-1000 on Base of the Thermo siphons

International Nuclear Information System (INIS)

Kirov, V.; Chulkin, O.

2008-01-01

One of NPP's systems providing safe operation is the system of emergency core cooling system (ECCS), which primary function in accidents is to flood the nuclear reactor core and to assure the sub critical condition and core cooling. At injection of cold water in reactor thermal stresses and thermal fatigue in the vessel cladding and constructional materials are arise. Low temperature of the water injected in reactor is a reason of occurrence of these undesirable consequences. Some variants of the water heating in accumulators of ECCS are considered. Now at Ukrainian NPPs the electrical heating in accumulators is used. Electrical heaters create the essential additional loading to diesel generators at imposing of two accidents - the large break and losses of power supplies on own needs. It is offered to use a heater in accumulators that working by a principle two-phase thermal siphon which advantages is: small dimensions, small delay and design reliability. In such heat exchanger the heating medium is a direct steam and the heated up medium is water with boric acid from accumulators of ECCS. Under requirements of the service regulations of ECCS accumulators it is necessary to guarantee injected water heating up to 90 ?? in case of a small break and to 150 ?? in case of the large break. Results of calculations for different external diameters of a tube of thermal siphon which have allowed to define the constructive sizes of heat exchanger, providing necessary conditions for required functioning of passive part ECCS are submitted The calculation and analysis of operating modes of the changed circuit of passive part ECCS for various accidents is carried out. The calculated pressure drop indicates that changes do not have essential influence on system work as a whole. Thus, the submitted decision provides the increase of reliability of ECCS at small and large breaks accidents, i.e. in all modes stipulated by the project.(author)

BREASTFEEDING AND EARLY CHILDHOOD CARIES (ECC SEVERITY OF CHILDREN UNDER THREE YEARS OLD IN DKI JAKARTA

Directory of Open Access Journals (Sweden)

Risqa Rina Darwita

2008-12-01

Full Text Available The prevalence and severity of caries in children under three years old are constantly increasing. One of the cause is the increase consumption of cariogenic carbohydrate. Breast milk have buffer capacity that eventually able to prevent caries. The aims of this research are to discover the correlation between breastfeeding with the severity of Early Childhood Caries (ECC in children under three years old, to provide information on prevalence and severity of caries in children under three years, and to explain factors influencing the incidence of ECC. This research designed cross sectionally and conducted upon 565 children aged 12-38 months, selected using multistage cluster random sampling. The ECC prevalence of children under three years in DKI Jakarta is 52.7%, with average score of def-t 2.85. Bivariate analysis showed that, variables which correlate with the level of ECC are; the way to deliver (p=0,012, frequency (p=0,002, duration (p=0,002, salivary buffer capacity (p=0.013, habitual consumption of sugary diet (p=0.005, child’s dental hygiene behavior (p=0.002, and mother’s education (p=0.001. Multivariate analysis showed that ECC can be explained by these variables: age, mother’s education, the way to deliver and frequency of breast milk complements/replacement of consumtions, child’s brushing habit, plaque pH, and salivary buffer capacity. Resulting determination coefficient 32.1%. There is no significant correlation between breastfeeding and the level of Early Childhood Caries (ECC. The role of protective qualities of breastfeeding are not shown because of bias in obtaining data influence the incidence of caries.

Transport and screen blockage characteristics of reflective metallic insulation materials

International Nuclear Information System (INIS)

Brocard, D.N.

1984-01-01

In the event of a LOCA within a nuclear power plant, it is possible for insulation debris to be generated by the break jet. Such debris has the potential for PWR sump screen (or BWR RHR suction inlet) blockage and thus can affect the long-term recirculation capability. In addition to the variables of break jet location and orientation, the types and quantities of debris which could be generated are dependent on the insulation materials employed. This experimental investigation was limited to reflective metallic insulation and components thereof. The study was aimed at determining the flow velocities needed to transport the insulation debris to the sump screens and the resulting modes of screen blockage. The tests revealed that thin metallic foils (0.0025 in. and 0.004 in.) could transport at low flow velocities, 0.2 to 0.5 ft/sec. Thicker foils (0.008 in.) transported at higher velocities, 0.4 to 0.8 ft/sec, and as fabricated half cylinder insulation units required velocities in excess of 1.0 ft/sec for transport. The tests also provided information on screen blockage patterns that showed blockage could occur at the lower portion of the screen as foils readily flipped on the screen when reaching it

Thermal hydraulic behavior of sub-assembly local blockage in China experiment fast reactor

International Nuclear Information System (INIS)

Yang Zhimin

2000-01-01

The geometrical parameter ratio of pitch to diameter of China Experiment Fast Reactor (CEFR) subassembly is 1,167. To address the thermal hydraulic behavior of subassembly local blockage which may be caused by deformation of cladding due to severe swelling and thermal stresses and by space swirl loosening etc., the porous numerical model and SIMPLE-P code used to solve Navier-Stokes and energy equations in porous medium was developed, and the bundle experiment with 19 pins with 24 subchannels blocked in the sodium coolant was carried on in China Institute of Atomic Energy (CIAE). The comparison of code predictions against experiments (including non-blockage and ten blockage conditions) seems well. The thermal hydraulic behavior of fuel subassembly with 61 fuel pins blockage of CEFR is calculated with SIMPLE-P code. The results indicate that the maximum temperature is 815 deg. C when the blockage area is about 37% (54 central subchannels are blocked). In this case the cladding won't be damaged and no sodium coolant boiling takes place. (author)

A survey of blockage measurement methods used in PWR multi-rod experiments

Energy Technology Data Exchange (ETDEWEB)

Hindle, E.D.; Jones, C.; Whitty, S. (AEA Reactor Services, Springfield (UK))

1986-05-01

The deformation characteristics of Zircaloy multi-rod arrays are being investigated in laboratory and in-reactor tests, and heat transfer experiments are being carried out on pre-deformed arrays. The primary objective is to demonstrate that cladding distension occurring under hypothetical loss-of-coolant accident (LOCA) conditions will not impede the PWR emergency coolant flow during the reflood stage to the extent that unacceptably high cladding temperatures are reached, i.e. that a coolable geometry is maintained. This Report critically reviews the current methods for measuring blockage in multi-rod arrays and discusses their application. A new definition which overcomes the deficiencies of the previous methods is proposed even though it still has drawbacks in the case of overall blockage measurement. A method for automatically measuring the individual rod strain, general cluster blockage sub-channel blockage and sub-channel perimeter changes is described and the results from a deformed array presented. (author).

A survey of blockage measurement methods used in PWR multi-rod experiments

International Nuclear Information System (INIS)

Hindle, E.D.; Jones, C.; Whitty, S.

1986-05-01

The deformation characteristics of Zircaloy multi-rod arrays are being investigated in laboratory and in-reactor tests, and heat transfer experiments are being carried out on pre-deformed arrays. The primary objective is to demonstrate that cladding distension occurring under hypothetical loss-of-coolant accident (LOCA) conditions will not impede the PWR emergency coolant flow during the reflood stage to the extent that unacceptably high cladding temperatures are reached, i.e. that a coolable geometry is maintained. This Report critically reviews the current methods for measuring blockage in multi-rod arrays and discusses their application. A new definition which overcomes the deficiencies of the previous methods is proposed even though it still has drawbacks in the case of overall blockage measurement. A method for automatically measuring the individual rod strain, general cluster blockage sub-channel blockage and sub-channel perimeter changes is described and the results from a deformed array presented. (author)

Comparison of allele frequency for HLA-DR and HLA-DQ between patients with ECC and caries-free children

Directory of Open Access Journals (Sweden)

Bagherian A

2008-03-01

Full Text Available Background: Early childhood caries (ECC is one of the most common diseases of childhood. The etiology of ECC is multifactorial and both genetic and environmental factors play important roles in the pathogenesis of the disease. Genetic variations in the hosts may contribute to changes in the risk for dental caries. Genetic factors such as human leukocyte antigen (HLA have recently been suggested as a predisposing factor. Aim: The aim of this study was to look for an association between HLA-DRB1 and HLA-DQB1 with ECC for developing new strategies for the diagnosis as well as the prevention of the disease. Design: In this study, we extracted the genomic DNAs from whole blood samples of 44 patients with ECC and 35 caries-free children by the salting-out method. We amplified the genomic DNA by PCR-SSP and then HLA-typing was performed for all alleles. Results: The results revealed a significant increase in the frequency of HLA-DRB1FNx0104 in the patient group (P = 0.019. The odds ratio for this allele was detected to be 10. The frequency of HLA-DQB1 alleles was not significantly different between the two groups. Conclusion: The above results suggest that HLA-DRB1FNx0104 is associated with the susceptibility to ECC. Thus HLA-DRB1FNx0104 detection as a molecular marker for early diagnosis of ECC may be recommended.

Air velocity profiles near sleeve blockages in an unheated 7 x 7 rod bundle. [PWR

Energy Technology Data Exchange (ETDEWEB)

Creer, J. M.; Bates, J. M.

1979-04-01

Local air velocity measurements were obtained with a laser Doppler anemometer near flow blockages in an unheated 7 x 7 rod bundle. Sleeve blockages were positioned on the center nine rods to create an area reduction of 90% in the center four subchannels of the bundle. Experimental results indicated that severe flow disturbances occurred downstream from the blockage cluster but showed only minor flow disturbances upstream from the blockage. Flow reversals were detected downstream from the blockage and persisted for approximately five subchannel hydraulic diameters. The air velocity profiles were in excellent agreement with water velocity data previously obtained at essentially the same Reynolds number. Subchannel average velocity predictions obtained with the COBRA computer program were in good agreement with subchannel average velocities estimated using the measured local velocity data.

Evaluation of ECC bypass data with a nonlinear constrained MLE technique

International Nuclear Information System (INIS)

Bishop, T.A.; Collier, R.P.; Kurth, R.E.

1980-01-01

Recently, Battelle's Columbus Laboratories have been involved in scale-model tests of emergency core cooling (ECC) systems for hypothesized loss-of-coolant accidents in pressurized water reactors (PWR). These tests are intended to increase our understanding of ECC bypass, which can occur when steam flow from the reactor core causes the emergency coolant to bypass the core and flow directly to the break. One objective of these experiments is the development of a correlation which relates the flow rate of water penetrating to the core to the steam flow rate. This correlation is derived from data obtained from a 2/15 scale model PWR at various ECC water injection rates, subcoolings, pressures, and steam flows. The general form of the correlation being studied is a modification of the correlation first proposed by Wallis. The correlation model is inherently nonlinear and implicit in form, and the model variables are all subject to error. Therefore, the usual nonlinear analysis techniques are inappropriate. A nonlinear constrained maximum-likelihood-estimation technique has been used to obtain estimates of the model parameters, and a Battelle-developed code, NLINMLE, has been used to analyze the data. The application of this technique is illustrated by sample calculations of estimates of the model parameters and their associated confidence intervals for selected experimental data sets. 5 figures, 7 tables

ECC delivery to lower plenum under downcomer injection part 2. RELAP5 assessment

International Nuclear Information System (INIS)

Bang, Young Seok; Shin, An Dong; Kim, Hho Jung

2000-01-01

In the present study, the capability of the thermal-hydraulic codes, RELAP5/MOD3.2.2 gamma, in predicting the steam-water interaction and the related ECC delivery to lower plenum under downcomer injection condition during refill phase is evaluated using the experimental data of the UPTF Test 21A. The facility is modeled in detail, and the test condition simulated for code calculations. The calculation result is compared with the applicable measurement data and discussed for the pressure response, ECC bypass behavior, lower plenum delivery, global water mass distribution, and local behavior in downcomer

UPTF-TRAM test A3. Turn-over of the hot-leg injected ECC in the steam generator direction

International Nuclear Information System (INIS)

Tenckhoff; Brand, B.; Weiss, P.

1993-06-01

The UPTF TRAM test A3 was a separate effects test to investigate the interaction between the hot leg-injected ECC and the single-phase or two-phase natural circulation in the hot leg in the case of an SBLOCA in a PWR. The experimental investigation of 7 runs was mainly concentrated on the following phenomena: - Transport of hot leg injected ECC water to the upper plenum or in the direction of steam generator, depending on the loop mass flow, -Utilization of the condensation potential of ECC water, - Mixing of the saturated water with the ECC water, - Effect of hot leg injection on the flow phenomena in the hot leg, - Effect of pressure (3 and 15 bar) on the scaling and hence the verification of the scaling concept applied. A preliminary evaluation of the test is presented in the Quick Look Report. (orig.) [de

Two-phase flow dynamics in ECC

International Nuclear Information System (INIS)

Albraaten, P.J.

1981-07-01

The present report summarizes the achievements within the project ''Two-phase Systems and ECC''. The results during 1978 - 1980 are accounted for in brief as they have been documented in earlier reports. The results during the first half of 1981 are accounted for in greater detail. They contain a new model for the Basset force and test runs with this model using the test code RISQUE. Furthermore, test runs have been performed with TRAC-PD2 MOD 1. This code was implemented on Edwards Pipe Blowdown experiment (a standard test case) and UC-Berkeley Reflooding experiment (a non-standard test case.) (Auth.)

Intercomparison of ozone measurements between Lidar and ECC-sondes

Energy Technology Data Exchange (ETDEWEB)

Grabbe, G.C. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Boesenberg, J. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Dier, H. [Meteorologisches Obs., Lindenberg (Germany); Goersdorf, U. [Meteorologisches Obs., Lindenberg (Germany); Matthias, V. [Max-Planck-Institut fuer Meteorologie, Hamburg (Germany); Peters, G. [Meteorologisches Obs., Lindenberg (Germany); Schaberl, T. [Hamburg Univ. (Germany). Meteorologisches Inst.; Senff, C. [Hamburg Univ. (Germany). Meteorologisches Inst.

1996-02-01

An intercomparison experiment for measurements of ozone vertical profiles in the lower troposphere was performed using a ground-based ozone DIAL (DIfferential Absorption Lidar) and ECC-sondes (Electrochemical Concentration Cell) attached to tethered as well as free flying balloons, which took place in June of 1994. The tethered balloon was used for ozone soundings in the planetary boundary layer up to an altitude of 500 m, while in the free troposphere free flying balloons were used. For the time series of up to 90 min obtained with the tethersondes both averages and standard deviations are compared. The mean difference for all measurements amounted to 3.5 {mu}g/m{sup 3} only, corresponding to 3.5%. For the instantaneous profiles compared to the free flying sondes the differences were only marginally larger, with a mean value of 3.6 {mu}g/m{sup 3} corresponding to 4.1%. With two exceptions all averages for a single profile stayed below 7 {mu}g/m{sup 3}. Larger individual excursions were observed. In some cases, in particular in regions of steep aerosol gradients at layer boundaries, most probably the lidar values cause the deviation, while in other cases the ECC-sonde is suspected to yield erroneous results. For the measured standard deviation those retrieved from DIAL measurements are generally larger than measured by the ECC-sondes, especially in regions of inhomogeneous aerosol distribution. For the measurements reported here, this is attributed to residual errors in the aerosol correction of the DIAL measurements. The general agreement found in this intercomparison is regarded as excellent, DIAL is proven to be a very valuable tool for detailed studies of the ozone distribution in the lower troposphere. (orig.)

Infertility caused by tubal blockage: An ayurvedic appraisal

Science.gov (United States)

Shukla (Upadhyaya), Kamayani; Karunagoda, Kaumadi; Dei, L. P.

2010-01-01

Tubal blockage is one of the most important factors for female infertility. This condition is not described in Ayurvedic classics, as the fallopian tube itself is not mentioned directly there. The present study is an effort to understand the disease according to Ayurvedic principles. Correlating fallopian tubes with the Artavavaha (Artava-bija-vaha) Srotas, its block is compared with the Sanga Srotodushti of this Srotas. Charak's opinion that the diseases are innumerable and newly discovered ones should be understood in terms of Prakriti, Adhishthana, Linga, and Aayatana, is followed, to describe this disease. An effort has been made to evaluate the role of all the three Doshas in producing blockage, with classification of the disease done as per the Dasha Roganika. PMID:22131704

ECCS evaluation of B and W's 205-FA NSS

International Nuclear Information System (INIS)

Lowe, R.J.; Anderson, G.E. Jr.; Dunn, B.M.

1975-06-01

The effectiveness of the ECCS for B and W's 205-fuel assembly plants is evaluated and shown to meet all the requirements of 10 CFR 50.46. The results of various sensitivity studies, a spectrum of breaks, and an analysis to determine allowable linear heat rates under 10 CFR 50.46 are presented. (14 references) (U.S.)

Effects of high temperature ECC injection on small and large break BWR LOCA simulation tests in ROSA-III program (RUNs 940 and 941)

International Nuclear Information System (INIS)

Suzuki, Mitsuhiro; Nakamura, Hideo; Kumamaru, Hiroshige; Anoda, Yoshinari; Yonomoto, Taisuke; Murata, Hideo; Tasaka, Kanji

1990-03-01

The ROSA-III program, of which principal results are summarized in a report of JAERI 1307, conducted small and large-break loss-of-coolant experiments (RUNs 940 and 941) with high water temperature of the emergency core cooling system (ECCS) are one of the parametric study with respect to the ECCS effect on core cooling. This report presents all the experiment results of these two tests and describes additional finding with respect to the hot ECC effects on core cooling phenomena. By comparing these two tests (water temperature of 393 K) with the standard ECC tests of RUNs 922 and 926 (water temperature of 313 K), it was found that the ECC subcooling variation had a small influence on the core cooling phenomena in 5 % small break tests but had larger influence on them in 200 % break tests. The ECC subcooling effects described in the previous report are reviewed and the temperature distribution in the pressure vessel is investigated for these four tests. (author)

Influence of leakage flow on the behaviour of gas behind a blockage in LMFBR subassembly geometry

International Nuclear Information System (INIS)

Fukuzawa, Y.

1980-07-01

Observations were made of the behaviour of gas behind a uniform porous 21% corner blockage within a pin-bundle of LMFBR subassembly geometry. The main parameter of the experiment was the leakage flow rate through the blockage. The behaviour of gas is significantly influenced by the leakage flow rate. The measured size and residence time of a gas cavity formed behind the blockage are shown and the mechanisms of the gas cavity dispersion by the leakage flow discussed by using a simple model of the liquid flow distribution behind the blockage. (orig.) [de

A study on design of the trip computer for ECCS based on dynamic safety system

International Nuclear Information System (INIS)

Kim, Seog Nam

2000-02-01

The Emergency Core Cooling system in current nuclear power plants typically has a considerable number of complex functions and largely cumbersome operator interfaces. Functions for initiation, switch-over between various phases of operation, interlocks, monitoring, and alarming are usually performed by relay and analog comparator logic which is difficult to maintain and test. To improve problems of an analog based ECC (Emergency Core Cooling) System, the trip computer for ECCS based on Dynamic Safety System is implemented. The Dynamic Safety System (DSS) is a computer based reactor protection system that has fail-safe nature and performs a dynamic self-testing. The most important feature of the DSS is the introduction of test signal that send the system into a tripped state. The test signals are interleaved between the plant signals to produce an output which switches between a tripped and health state. The dynamic operation is a key feature of the failsafe design of the system. In this thesis, a possible implementation of the DSS using PLC is presented for a CANDU reactor. ECC System of the CANDU Reactor is selected as the reference system. The function of the DSS is implemented In PLC with the CONCEPT language. CONCEPT was developed by GROUPE SCHNEIDER as a graphic user interface programming tool for the Quantum PLC. A MMI display for ECCS based on DSS is implemented with LOOKOUT as an object driven programming tool. The Validation test has been performed by S/W Input Simulator as per Validation Test Procedure. The result of the test was checked and displayed on the MMI display. From the test results, it is shown that the DSS based ECC System operates correctly in all conditions

A PWR reactor downcomer modification for reduction of ECC bypass flow during LOCA

International Nuclear Information System (INIS)

Popov, N.; Bosevski, T.

1986-01-01

The ECC bypass phenomenon in the PWR reactor down-comer, which delays the reactor vessel refilling, after cold leg large break LOCA accident, has been subject of analysis in this paper. In the paper, a particular construction modification of the reactor down-comer has been suggested by inserting vertical ribs, aimed to intensify the reactor ECC refilling following the LOCA accident, and to advance the thermal-hydraulics safety of post-accidental cooling of the PWR reactors. To verify the effectiveness of the suggested down-comer construction modification, some properly selected results, obtained by corresponding verified mathematical model, have been presented in this paper. (author)

Modeling of ECC materials using numerical formulations based on plasticity

DEFF Research Database (Denmark)

Dick-Nielsen, Lars; Stang, Henrik; Poulsen, Peter Noe

2006-01-01

scale it is shown that the cohesive law for a unidirectional fiber reinforced cementitious composite can be found through superposition of the cohesive law for mortar and the fiber bridging curve. On the meso scale I it is shown that the maximum crack opening observed during crack propagation in ECC...

Disease Management of Early Childhood Caries: ECC Collaborative Project.

Science.gov (United States)

Ng, Man Wai; Ramos-Gomez, Francisco; Lieberman, Martin; Lee, Jessica Y; Scoville, Richard; Hannon, Cindy; Maramaldi, Peter

2014-01-01

Until recently, the standard of care for early childhood caries (ECC) has been primarily surgical and restorative treatment with little emphasis on preventing and managing the disease itself. It is now recognized that surgical treatment alone does not address the underlying etiology of the disease. Despite costly surgeries and reparative treatment, the onset and progression of caries are likely to continue. A successful rebalance of risk and protective factors may prevent, slow down, or even arrest dental caries and its progression. An 18-month risk-based chronic disease management (DM) approach to address ECC in preschool children was implemented as a quality improvement (QI) collaborative by seven teams of oral health care providers across the United States. In the aggregate, fewer DM children experienced new cavitation, pain, and referrals to the operating room (OR) for restorative treatment compared to baseline historical controls. The teams found that QI methods facilitated adoption of the DM approach and resulted in improved care to patients and better outcomes overall. Despite these successes, the wide scale adoption and spread of the DM approach may be limited unless health policy and payment reforms are enacted to compensate providers for implementing DM protocols in their practice.

Occurrence of blockage in cut stems of Clematis L.

Directory of Open Access Journals (Sweden)

Agata Jędrzejuk

2013-04-01

Full Text Available During vase life of cut flowers obstructions in stem xylem vessels develop. Such obstructions may restrict water uptake in stems and its transport towards flowers, thus lowering their ornamental value and longevity. Clematis is a very attractive plant which can be used as a cut flower in floral compositions. However, nothing is known about the histochemical or cytolo- gical nature of xylem blockages occurring in cut stems of this plant. Observations carried out on Clematis cv. 'Solidarność' proved that tyloses appeared as a principal source of xylem blockage in cut stems. The preservative composed of 200 mg × dm-3 8-HQC (8-hydroxyquinolin citrate and 2% sucrose arre-sted development of xylem blockage, while the vessels in stems kept in water were filled with tyloses or an amorphic substance. PAS reaction proved that polysaccharides were present in the xylem occlusions, whereas no homogalacturonans were immunolocalized in tyloses using JIM 5 and JIM 7 antibodies. The present study provides new information on the origin of xylem occlusions in clematis and their development in two different vase solutions. Such information can be useful to develop pro- per postharvest treatments aiming to improve keeping qualities of this new cut flower.

Design and Development of Vision Based Blockage Clearance Robot for Sewer Pipes

Directory of Open Access Journals (Sweden)

Krishna Prasad Nesaian

2012-03-01

Full Text Available Robotic technology is one of the advanced technologies, which is capable of completing tasks at situations where humans are unable to reach, see or survive. The underground sewer pipelines are the major tools for the transportation of effluent water. A lot of troubles caused by blockage in sewer pipe will lead to overflow of effluent water, sanitation problems. So robotic vehicle that is capable of traveling at underneath effluent water determining blockage using ultrasonic sensors and clearing by means of drilling mechanism is done. In addition to that wireless camera is fixed which acts as a robot vision by which we can monitor video and capture images using MATLAB tool. Thus in this project a prototype model of underground sewer pipe blockage clearance robot with drilling type will be developed

Minimum containment pressure and its effect on ECCS performance of APR-1400

International Nuclear Information System (INIS)

Kim, In Goo; Bang, Young S.; Kim, Hho Jung

2004-01-01

The containment pressure has a strong effect on the late reheat behavior for a large break LOCA, associated with the DVI issue. The downcomer boiling, which occurs during the post-reflood phase, has a negative effect on core cooling for a LBLOCA. Because the downcomer boiling is enhanced as the containment pressure decreases, how to determine containment pressure is important to the evaluation of ECCS performance. In spite of its importance of containment pressure, there are few studies on the containment pressure and the interaction between RCS and containment thermal hydraulics. To have a better knowledge of the effect of containment pressure on APR-1400 ECCS performance, a parametric study for containment pressure has been carried out. Also, the interaction between RCS and containment behavior has been also investigated

Compendium of ECCS [Emergency Core Cooling Systems] research for realistic LOCA [loss-of-coolant accidents] analysis: Final report

International Nuclear Information System (INIS)

1988-12-01

In the United States, Emergency Core Cooling Systems (ECCS) are required for light water reactors (LWRs) to provide cooling of the reactor core in the event of a break or leak in the reactor piping or an inadvertent opening of a valve. These accidents are called loss-of-coolant accidents (LOCA), and they range from small leaks up to a postulated full break of the largest pipe in the reactor cooling system. Federal government regulations provide that LOCA analysis be performed to show that the ECCS will maintain fuel rod cladding temperatures, cladding oxidation, and hydrogen production within certain limits. The NRC and others have completed a large body of research which investigated fuel rod behavior and LOCA/ECCS performance. It is now possible to make a realistic estimate of the ECCS performance during a LOCA and to quantify the uncertainty of this calculation. The purpose of this report is to summarize this research and to serve as a general reference for the extensive research effort that has been performed. The report: (1) summarizes the understanding of LOCA phenomena in 1974; (2) reviews experimental and analytical programs developed to address the phenomena; (3) describes the best-estimate computer codes developed by the NRC; (4) discusses the salient technical aspects of the physical phenomena and our current understanding of them; (5) discusses probabilistic risk assessment results and perspectives, and (6) evaluates the impact of research results on the ECCS regulations. 736 refs., 412 figs., 66 tabs

Simultaneous algae-polluted water treatment and electricity generation using a biocathode-coupled electrocoagulation cell (bio-ECC).

Science.gov (United States)

Dong, Yue; Qu, Youpeng; Li, Chao; Han, Xiaoyu; Ambuchi, John J; Liu, Junfeng; Yu, Yanling; Feng, Yujie

2017-10-15

How to utilize electrocoagulation (EC) technology for algae-polluted water treatment in an energy-efficient manner remains a critical challenge for its widespread application. Herein, a novel biocathode-coupled electrocoagulation cell (bio-ECC) with sacrificial iron anode and nitrifying biocathode was developed. Under different solution conductivities (2.33±0.25mScm -1 and 4.94±0.55mScm -1 ), the bio-ECC achieved almost complete removal of algae cells. The maximum power densities of 8.41 and 11.33Wm -3 at corresponding current densities of 48.03Am -3 and 66.26Am -3 were obtained, with the positive energy balance of 4.52 and 7.44Wm -3 . In addition, the bio-ECC exhibited excellent NH 4 + -N removal performance with the nitrogen removal rates of 7.28mgL -1 h -1 and 6.77mgL -1 h -1 in cathode chamber, indicating the superiority of bio-ECC in NH 4 + -N removal. Pyrosequencing revealed that nitrifiers including Nitrospira, Nitrobacter, Nitrosococcus, and Nitrosomonas were enriched in biocathode. The removal mechanisms of algae in anode chamber were also explored by AFM and SEM-EDX tests. These results provide a proof-of-concept study of transferring energy-intensive EC process into an energy-neutral process with high-efficiency algae removal and electricity recovery. Copyright © 2017. Published by Elsevier B.V.

PWR FLECHT SEASET 21-rod bundle flow blockage task. Task plan report. FLECHT SEASET Program report No. 5

International Nuclear Information System (INIS)

Hochreiter, L.E.; Basel, R.A.; Dennis, R.J.; Lee, N.; Massie, H.W. Jr.; Loftus, M.J.; Rosal, E.R.; Valkovic, M.M.

1980-10-01

This report presents a descriptive plan of tests for the 21-Rod Bundle Flow Blockage Task of the Full-Length Emergency Cooling Heat Transfer Separate Effects and Systems Effects Test Program (FLECHT SEASET). This task will consist of forced and gravity reflooding tests utilizing electrical heater rods to simulate PWR nuclear core fuel rod arrays. All tests will be performed with a cosine axial power profile. These tests are planned to be used to determine effects of various flow blockage configurations (shapes and distributions) on reflooding behavior, to aid in development/assessment of computational models in predicting reflooding behavior of flow blockage configurations, and to screen flow blockage configurations for future 161-rod flow blockage bundle tests

Using ECC DRAM to Adaptively Increase Memory Capacity

OpenAIRE

Luo, Yixin; Ghose, Saugata; Li, Tianshi; Govindan, Sriram; Sharma, Bikash; Kelly, Bryan; Boroumand, Amirali; Mutlu, Onur

2017-01-01

Modern DRAM modules are often equipped with hardware error correction capabilities, especially for DRAM deployed in large-scale data centers, as process technology scaling has increased the susceptibility of these devices to errors. To provide fast error detection and correction, error-correcting codes (ECC) are placed on an additional DRAM chip in a DRAM module. This additional chip expands the raw capacity of a DRAM module by 12.5%, but the applications are unable to use any of this extra c...

Preestrita pihtimus : Friedrich Nietzsche ja tema substantsiaalne mina (Ecce homo) / Jaan Undusk

Index Scriptorium Estoniae

Undusk, Jaan, 1958-

1998-01-01

Varem ilmunud raamatu järelsõnana: Nietzsche, Friedrich. Ecce homo : kuidas saadakse selleks, mis ollakse / tlk. Jaan Undusk. Tallinn : Vagabund, 1996. Sisu: Poeetiline, filosoofiline, dionüüsiline kaanon ; Künism contra hulluskahtlus ; Antikristlik pihtimus ; Egoretoorika

Predictive Eco-Cruise Control (ECC) system : model development, modeling and potential benefits.

Science.gov (United States)

2013-02-01

The research develops a reference model of a predictive eco-cruise control (ECC) system that intelligently modulates vehicle speed within a pre-set speed range to minimize vehicle fuel consumption levels using roadway topographic information. The stu...

Advanced evaluation method of SG TSP BEC hole blockage rate

International Nuclear Information System (INIS)

Izumida, Hiroyuki; Nagata, Yasuyuki; Harada, Yutaka; Murakami, Ryuji

2003-01-01

In spite of the control of the water chemistry of SG secondary feed-water in PWR-SG, SG TSP BEC holes, which are the flow path of secondary water, are often clogged. In the past, the trending of BEC hole blockage rate has conducted by evaluating ECT original signals and visual inspections. However, the ECT original signals of deposits are diversified, it becomes difficult to analyze them with the existing evaluation method using the ECT original signals. In this regard, we have developed the secondary side visual inspection system, which enables the high-accuracy evaluation of BEC hole blockage rate, and new ECT signal evaluation method. (author)

Failure Mode and Effects Analysis (FMEA) of the Emergency Core Cooling System (ECCS) for a Westinghouse type 312, three loop pressurized water reactor

International Nuclear Information System (INIS)

Shopsky, W.E.

1977-01-01

The Emergency Core Cooling System (ECCS) is a Safeguards System designed to cool the core in the unlikely event of a Loss-of-Coolant Accident (LOCA) in the primary reactor coolant system as well as to provide additional shutdown capability following a steam break accident. The system is designed for a high reliability of providing emergency coolant and shutdown reactivity to the core for all anticipated occurrences of such accidents. The ECCS by performing its intended function assures that fuel and clad damage is minimized during accident conditions thus reducing release of fission products from the fuel. The ECCS is designed to perform its function despite sustaining a single failure by the judicious use of equipment and flow path redundancy within and outside the containment structure. By the use of an analytic tool, a Failure Mode and Effects Analysis (FMEA), it is shown that the ECCS is in compliance with the Single Failure Criterion established for active failures of fluid systems during short and long term cooling of the reactor core following a LOCA or steam break accident. An analysis was also performed with regards to passive failure of ECCS components during long-term cooling of the core following an accident. The design of the ECCS was verified as being able to tolerate a single passive failure during long-term cooling of the reactor core following an accident. The FMEA conducted qualitatively demonstrates the reliability of the ECCS (concerning active components) to perform its intended safety function

Blockage of mitochondrial calcium uniporter prevents iron accumulation in a model of experimental subarachnoid hemorrhage

Energy Technology Data Exchange (ETDEWEB)

Yan, Huiying [Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province (China); Hao, Shuangying; Sun, Xiaoyan [Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, 22 Hankou Road, Nanjing 210093, Jiangsu Province (China); Zhang, Dingding; Gao, Xin; Yu, Zhuang [Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province (China); Li, Kuanyu, E-mail: likuanyu@nju.edu.cn [Jiangsu Key Laboratory for Molecular Medicine, Medical School of Nanjing University, 22 Hankou Road, Nanjing 210093, Jiangsu Province (China); Hang, Chun-Hua, E-mail: hang_neurosurgery@163.com [Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province (China)

2015-01-24

Highlights: • Iron accumulation was involved in the acute phase following SAH. • Blockage of MCU could attenuate cellular iron accumulation following SAH. • Blockage of MCU could decrease ROS generation and improve cell energy supply following SAH. • Blockage of MCU could alleviate apoptosis and brain injury following SAH. - Abstract: Previous studies have shown that iron accumulation is involved in the pathogenesis of brain injury following subarachnoid hemorrhage (SAH) and chelation of iron reduced mortality and oxidative DNA damage. We previously reported that blockage of mitochondrial calcium uniporter (MCU) provided benefit in the early brain injury after experimental SAH. This study was undertaken to identify whether blockage of MCU could ameliorate iron accumulation-associated brain injury following SAH. Therefore, we used two reagents ruthenium red (RR) and spermine (Sper) to inhibit MCU. Sprague–Dawley (SD) rats were randomly divided into four groups including sham, SAH, SAH + RR, and SAH + Sper. Biochemical analysis and histological assays were performed. The results confirmed the iron accumulation in temporal lobe after SAH. Interestingly, blockage of MCU dramatically reduced the iron accumulation in this area. The mechanism was revealed that inhibition of MCU reversed the down-regulation of iron regulatory protein (IRP) 1/2 and increase of ferritin. Iron–sulfur cluster dependent-aconitase activity was partially conserved when MCU was blocked. In consistence with this and previous report, ROS levels were notably reduced and ATP supply was rescued; levels of cleaved caspase-3 dropped; and integrity of neurons in temporal lobe was protected. Taken together, our results indicated that blockage of MCU could alleviate iron accumulation and the associated injury following SAH. These findings suggest that the alteration of calcium and iron homeostasis be coupled and MCU be considered to be a therapeutic target for patients suffering from SAH.

Transcription blockage by stable H-DNA analogs in vitro.

Science.gov (United States)

Pandey, Shristi; Ogloblina, Anna M; Belotserkovskii, Boris P; Dolinnaya, Nina G; Yakubovskaya, Marianna G; Mirkin, Sergei M; Hanawalt, Philip C

2015-08-18

DNA sequences that can form unusual secondary structures are implicated in regulating gene expression and causing genomic instability. H-palindromes are an important class of such DNA sequences that can form an intramolecular triplex structure, H-DNA. Within an H-palindrome, the H-DNA and canonical B-DNA are in a dynamic equilibrium that shifts toward H-DNA with increased negative supercoiling. The interplay between H- and B-DNA and the fact that the process of transcription affects supercoiling makes it difficult to elucidate the effects of H-DNA upon transcription. We constructed a stable structural analog of H-DNA that cannot flip into B-DNA, and studied the effects of this structure on transcription by T7 RNA polymerase in vitro. We found multiple transcription blockage sites adjacent to and within sequences engaged in this triplex structure. Triplex-mediated transcription blockage varied significantly with changes in ambient conditions: it was exacerbated in the presence of Mn(2+) or by increased concentrations of K(+) and Li(+). Analysis of the detailed pattern of the blockage suggests that RNA polymerase is sterically hindered by H-DNA and has difficulties in unwinding triplex DNA. The implications of these findings for the biological roles of triple-stranded DNA structures are discussed. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Statistical analysis and definition of blockages-prediction formulae for the wastewater network of Oslo by evolutionary computing.

Science.gov (United States)

Ugarelli, Rita; Kristensen, Stig Morten; Røstum, Jon; Saegrov, Sveinung; Di Federico, Vittorio

2009-01-01

Oslo Vann og Avløpsetaten (Oslo VAV)-the water/wastewater utility in the Norwegian capital city of Oslo-is assessing future strategies for selection of most reliable materials for wastewater networks, taking into account not only material technical performance but also material performance, regarding operational condition of the system.The research project undertaken by SINTEF Group, the largest research organisation in Scandinavia, NTNU (Norges Teknisk-Naturvitenskapelige Universitet) and Oslo VAV adopts several approaches to understand reasons for failures that may impact flow capacity, by analysing historical data for blockages in Oslo.The aim of the study was to understand whether there is a relationship between the performance of the pipeline and a number of specific attributes such as age, material, diameter, to name a few. This paper presents the characteristics of the data set available and discusses the results obtained by performing two different approaches: a traditional statistical analysis by segregating the pipes into classes, each of which with the same explanatory variables, and a Evolutionary Polynomial Regression model (EPR), developed by Technical University of Bari and University of Exeter, to identify possible influence of pipe's attributes on the total amount of predicted blockages in a period of time.Starting from a detailed analysis of the available data for the blockage events, the most important variables are identified and a classification scheme is adopted.From the statistical analysis, it can be stated that age, size and function do seem to have a marked influence on the proneness of a pipeline to blockages, but, for the reduced sample available, it is difficult to say which variable it is more influencing. If we look at total number of blockages the oldest class seems to be the most prone to blockages, but looking at blockage rates (number of blockages per km per year), then it is the youngest class showing the highest blockage rate

Development of CANDU ECCS performance evaluation methodology and guides

Energy Technology Data Exchange (ETDEWEB)

Bang, Kwang Hyun; Park, Kyung Soo; Chu, Won Ho [Korea Maritime Univ., Jinhae (Korea, Republic of)

2003-03-15

The objectives of the present work are to carry out technical evaluation and review of CANDU safety analysis methods in order to assist development of performance evaluation methods and review guides for CANDU ECCS. The applicability of PWR ECCS analysis models are examined and it suggests that unique data or models for CANDU are required for the following phenomena: break characteristics and flow, frictional pressure drop, post-CHF heat transfer correlations, core flow distribution during blowdown, containment pressure, and reflux rate. For safety analysis of CANDU, conservative analysis or best estimate analysis can be used. The main advantage of BE analysis is a more realistic prediction of margins to acceptance criteria. The expectation is that margins demonstrated with BE methods would be larger that when a conservative approach is applied. Some outstanding safety analysis issues can be resolved by demonstration that accident consequences are more benign than previously predicted. Success criteria for analysis and review of Large LOCA can be developed by top-down approach. The highest-level success criteria can be extracted from C-6 and from them, the lower level criteria can be developed step-by-step, in a logical fashion. The overall objectives for analysis and review are to verify radiological consequences and frequency are met.

Disease Management of Early Childhood Caries: ECC Collaborative Project

Directory of Open Access Journals (Sweden)

Man Wai Ng

2014-01-01

Full Text Available Until recently, the standard of care for early childhood caries (ECC has been primarily surgical and restorative treatment with little emphasis on preventing and managing the disease itself. It is now recognized that surgical treatment alone does not address the underlying etiology of the disease. Despite costly surgeries and reparative treatment, the onset and progression of caries are likely to continue. A successful rebalance of risk and protective factors may prevent, slow down, or even arrest dental caries and its progression. An 18-month risk-based chronic disease management (DM approach to address ECC in preschool children was implemented as a quality improvement (QI collaborative by seven teams of oral health care providers across the United States. In the aggregate, fewer DM children experienced new cavitation, pain, and referrals to the operating room (OR for restorative treatment compared to baseline historical controls. The teams found that QI methods facilitated adoption of the DM approach and resulted in improved care to patients and better outcomes overall. Despite these successes, the wide scale adoption and spread of the DM approach may be limited unless health policy and payment reforms are enacted to compensate providers for implementing DM protocols in their practice.

Studies on the effects of blockage upon LWR emergency core cooling systems

International Nuclear Information System (INIS)

Fairbairn, S.A.; Piggott, B.D.G.

1985-01-01

Ballooning of the zircaloy cladding of PWR fuel pins could occur during certain postulated Loss of Coolant Accidents. This report describes experimental data obtained in a 44-rod bundle with and without a localized coplanar blockage under conditions relevant to the reflood phase of a LOCA. The aim of the work is to provide a data base for modelling dispersed flow heat transfer around a local blockage. This work concentrates on the thermohydraulic aspects of the ballooning problem by use of pre-formed balloon shapes attached to the rods of an electrically heated rod bundle. The various thermohydraulic effects are investigated separately, as far as possible, in a unique series of tests of increasing complexity proceeding from single to two phase conditions as follows: isothermal air flow tests, used to infer the single phase mass flow distribution; steady state steam flow tests, used to quantify single phase heat transfer; steam and droplet tests, in which a dispersed flow of well specified inlet conditions is created by injecting water droplets into the subchannel centres between the rods with a co-current steam flow; and finally, conventional reflood tests. The first part makes an extensive presentation of all the data obtained for an undistorted bundle and a bundle containing a centrally placed 4x4 array of balloon shapes (approximately 50 mm long, solid) which create a 90% subchannel blockage at their centre elevations. In part 2 tests on two blockage shapes each producing 90% subchannel blockage are described. The first shape is composed of thick walled sleeves (1.0 to 2.5 mm) and the second of sleeves with a more realistic thermal capacity being only about 0.3 mm thick. 48 refs., 335 figs.

Compressive Sensing for Blockage Detection in Vehicular Millimeter Wave Antenna Arrays

KAUST Repository

Eltayeb, Mohammed E.; Al-Naffouri, Tareq Y.; Heath, Robert W.

2017-01-01

The radiation pattern of an antenna array depends on the excitation weights and the geometry of the array. Due to mobility, some vehicular antenna elements might be subjected to full or partial blockages from a plethora of particles like dirt, salt, ice, and water droplets. These particles cause absorption and scattering to the signal incident on the array, and as a result, change the array geometry. This distorts the radiation pattern of the array mostly with an increase in the sidelobe level and decrease in gain. In this paper, we propose a blockage detection technique for millimeter wave vehicular antenna arrays that jointly estimates the locations of the blocked antennas and the attenuation and phase-shifts that result from the suspended particles. The proposed technique does not require the antenna array to be physically removed from the vehicle and permits real-time array diagnosis. Numerical results show that the proposed technique provides satisfactory results in terms of block detection with low detection time provided that the number of blockages is small compared to the array size.

Compressive Sensing for Blockage Detection in Vehicular Millimeter Wave Antenna Arrays

KAUST Repository

Eltayeb, Mohammed E.

2017-02-07

The radiation pattern of an antenna array depends on the excitation weights and the geometry of the array. Due to mobility, some vehicular antenna elements might be subjected to full or partial blockages from a plethora of particles like dirt, salt, ice, and water droplets. These particles cause absorption and scattering to the signal incident on the array, and as a result, change the array geometry. This distorts the radiation pattern of the array mostly with an increase in the sidelobe level and decrease in gain. In this paper, we propose a blockage detection technique for millimeter wave vehicular antenna arrays that jointly estimates the locations of the blocked antennas and the attenuation and phase-shifts that result from the suspended particles. The proposed technique does not require the antenna array to be physically removed from the vehicle and permits real-time array diagnosis. Numerical results show that the proposed technique provides satisfactory results in terms of block detection with low detection time provided that the number of blockages is small compared to the array size.

On the energy shift of the ECC cusp. Does the shift really exist?

International Nuclear Information System (INIS)

Barrachina, R.O.; Sarkadi, L.

2004-01-01

Full text: The cusplike 'electron capture to the continuum' (ECC) peak appearing in the spectrum of the forward emitted electrons in ion-atom collisions is generally thought to be a divergence. The peak is centered at electron velocity that matches that of the projectile. Recently Illescas et al. [1] claimed, however, that 'the cusp is not a divergence smoothed by the experiment, and is slightly shifted from the impact-velocity value'. In a subsequent work Shah et al. [2] measured the ECC cusp for collisions of 10- and 20- keV protons with H2 and He, and found that the peak was indeed shifted to a velocity below its expected position. Their classical trajectory Monte Carlo (CTMC) calculations reproduced the observation well. In the present work we demonstrate by our CTMC calculations (made for the case of 20-keV protons on He) that the intensity, width and position of the ECC cusp do depend on the experimental conditions by which the electrons are detected (first of all, the acceptance angle of the electron spectrometer). We also present experimental data for this collision system. While the latter data are well reproduced by our CTMC calculations, neither the theoretical results, nor the experimental data of the present work support of the findings of Shah et al. [2]. At the same time, analyzing the problem in the framework of the general final-state interaction theory of cusp formation [3], we concluded that 'rigorously' speaking Shah et al. [2] are right when they state that the ECC cusp is not a divergence. The divergence is smeared out by the scattering of the projectile. However, this effect is negligibly small at the lowest energy that was considered in their paper, 10 keV. At this impact energy the projectile motion is smeared within an angular region Δθ th ∼ 0.06 deg, which is much smaller than the acceptance angle of the experiment, Δθ exp ∼ 1.5 deg

Scaling and design report of ECC performance test facility (SWAT) of SMART

International Nuclear Information System (INIS)

Cho, Seok; Ko, Yong Ju; Cho, Young Il; Kim, Jeong Tak; Choi, Nam Hyun; Shin Yong Chul; Park, Choon Kyong; Kwon, Tae Soon; Lee, Sung Jae

2010-12-01

SWAT (SMART ECC Water Asymmetric Two-phase choking test facility) was designed by 1/5 scaling ratio using the modified linear scaling method. The design characteristics of the SMART such that the elevation of RCP suction nozzles is the same with that of the ECC injection nozzles are maintained to reduce a distortion caused by the gravitational effect. Thermal hydraulic phenomena in a test facility designed by the modified linear scaling method can be simulated more accurately than those by the full-height and reduced area scaling method. The main part of the test section is SG-side upper down-comer. The boundary conditions are saturated steam and water flow condition and drain flow rate to control the collapsed water level in the down-comer. The test data of the SWAT can produce the well-defined boundary condition to validate the thermal hydraulic analysis code for the SMART

Scaling and design report of ECC performance test facility (SWAT) of SMART

Energy Technology Data Exchange (ETDEWEB)

Cho, Seok; Ko, Yong Ju; Cho, Young Il; Kim, Jeong Tak; Choi, Nam Hyun; Shin Yong Chul; Park, Choon Kyong; Kwon, Tae Soon; Lee, Sung Jae [KAERI, Daejeon (Korea, Republic of)

2010-12-15

SWAT (SMART ECC Water Asymmetric Two-phase choking test facility) was designed by 1/5 scaling ratio using the modified linear scaling method. The design characteristics of the SMART such that the elevation of RCP suction nozzles is the same with that of the ECC injection nozzles are maintained to reduce a distortion caused by the gravitational effect. Thermal hydraulic phenomena in a test facility designed by the modified linear scaling method can be simulated more accurately than those by the full-height and reduced area scaling method. The main part of the test section is SG-side upper down-comer. The boundary conditions are saturated steam and water flow condition and drain flow rate to control the collapsed water level in the down-comer. The test data of the SWAT can produce the well-defined boundary condition to validate the thermal hydraulic analysis code for the SMART

Effect of a blockage length on the coolability during reflood in a 2 × 2 rod bundle with a 90% partially blocked region

Energy Technology Data Exchange (ETDEWEB)

Kim, Kihwan, E-mail: kihwankim@kaeri.re.kr [Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Yuseong-Gu, Daejeon 34057 (Korea, Republic of); Kim, Byung-Jae, E-mail: byoungjae@kaeri.re.kr [School of Mechanical Engineering, Chungnam National University, 99 Daehak-ro, Yuseoung-Gu, Daejeon 34134 (Korea, Republic of); Choi, Hae-Seob, E-mail: hschoi@kaeri.re.kr [Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Yuseong-Gu, Daejeon 34057 (Korea, Republic of); Moon, Sang-Ki, E-mail: skmoon@kaeri.re.kr [Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Yuseong-Gu, Daejeon 34057 (Korea, Republic of); Song, Chul-Hwa, E-mail: chsong@kaeri.re.kr [Korea Atomic Energy Research Institute, Daeduk-daero 989-111, Yuseong-Gu, Daejeon 34057 (Korea, Republic of)

2017-02-15

Highlights: • This test was conducted to understand the effect of blockage length on the coolability. • Reflood tests were conducted with blockage simulators for various reflood rates. • The coolability in the downstream of the blockage region is significantly enhanced. - Abstract: If fuel rods are ballooned or rearranged during the reflood phase of a large break loss-of-coolant accident (LBLOCA) in a pressurized-water reactor (PWR), the transient heat transfer behavior is entirely different with those of the intact fuel rods owing to the deformed blockage region. The coolability in the blocked region depends on a complex two-phase heat transfer with various thermal hydraulic conditions. In addition, the blockage characteristics, such as the blockage ratio, length, shape, and configurations, are also significant factors affecting the coolability. In the present study, reflood experiments were carried out to understand the effect of the blockage length upon the coolability by varying the reflooding rates. The experiments were performed in electrically heated 2 × 2 rod bundles with blockage simulators having the same blockage ratio but different blockage lengths. The characteristics of quenching and heat transfer were evaluated to investigate the influence of the blockage region on the coolability. The droplet behaviors were also observed by measuring the droplets velocity and size near the blockage region. The coolability in the downstream region of the blockage was significantly enhanced, owing to the reduced flow area of the sub-channel, intensification of turbulence, and the entrained droplets in the blockage region.

ECCS analysis of B and W's 177-FA lowered-loop NSS

International Nuclear Information System (INIS)

Jones, R.C.; Biller, J.R.; Dunn, B.M.

1975-06-01

The effectiveness for the ECCS for B and W's 177-FA Lowered-Loop NSS is shown to meet the five criteria of 10 CFR 50.46. A spectrum analysis is performed and the worst case is used to establish allowable linear heat rates as a function of elevation in the core. (U.S.)

Development of an Infection-Responsive Fluorescent Sensor for the Early Detection of Urinary Catheter Blockage.

Science.gov (United States)

Milo, Scarlet; Acosta, Florianne B; Hathaway, Hollie J; Wallace, Laura A; Thet, Naing T; Jenkins, A Toby A

2018-03-23

Formation of crystalline biofilms following infection by Proteus mirabilis can lead to encrustation and blockage of long-term indwelling catheters, with serious clinical consequences. We describe a simple sensor, placed within the catheter drainage bag, to alert of impending blockage via a urinary color change. The pH-responsive sensor is a dual-layered polymeric "lozenge", able to release the self-quenching dye 5(6)-carboxyfluorescein in response to the alkaline urine generated by the expression of bacterial urease. Sensor performance was evaluated within a laboratory model of the catheterized urinary tract, infected with both urease positive and negative bacterial strains under conditions of established infection, achieving an average "early warning" of catheter blockage of 14.5 h. Signaling only occurred following infection with urease positive bacteria. Translation of these sensors into a clinical environment would allow appropriate intervention before the occurrence of catheter blockage, a problem for which there is currently no effective control method.

Study of Impact Damage in PVA-ECC Beam under Low-Velocity Impact Loading Using Piezoceramic Transducers and PVDF Thin-Film Transducers.

Science.gov (United States)

Qi, Baoxin; Kong, Qingzhao; Qian, Hui; Patil, Devendra; Lim, Ing; Li, Mo; Liu, Dong; Song, Gangbing

2018-02-24

Compared to conventional concrete, polyvinyl alcohol fiber reinforced engineering cementitious composite (PVA-ECC) offers high-strength, ductility, formability, and excellent fatigue resistance. However, impact-induced structural damage is a major concern and has not been previously characterized in PVA-ECC structures. We investigate the damage of PVA-ECC beams under low-velocity impact loading. A series of ball-drop impact tests were performed at different drop weights and heights to simulate various impact energies. The impact results of PVA-ECC beams were compared with mortar beams. A combination of polyvinylidene fluoride (PVDF) thin-film sensors and piezoceramic-based smart aggregate were used for impact monitoring, which included impact initiation and crack evolution. Short-time Fourier transform (STFT) of the signal received by PVDF thin-film sensors was performed to identify impact events, while active-sensing approach was utilized to detect impact-induced crack evolution by the attenuation of a propagated guided wave. Wavelet packet-based energy analysis was performed to quantify failure development under repeated impact tests.

Development of multi-dimensional analysis method for porous blockage in fuel subassembly. Numerical simulation for 4 subchannel geometry water test

International Nuclear Information System (INIS)

Tanaka, Masa-aki; Kamide, Hideki

2001-02-01

This investigation deals with the porous blockage in a wire spacer type fuel subassembly in Fast Breeder Reactors (FBR's). Multi-dimensional analysis method for a porous blockage in a fuel subassembly is developed using the standard k-ε turbulence model with the typical correlations in handbooks. The purpose of this analysis method is to evaluate the position and the magnitude of the maximum temperature, and to investigate the thermo-hydraulic phenomena in the porous blockage. Verification of this analysis method was conducted based on the results of 4-subchannel geometry water test. It was revealed that the evaluation of the porosity distribution and the particle diameter in a porous blockage was important to predict the temperature distribution. This analysis method could simulate the spatial characteristic of velocity and temperature distributions in the blockage and evaluate the pin surface temperature inside the porous blockage. Through the verification of this analysis method, it is shown that this multi-dimensional analysis method is useful to predict the thermo-hydraulic field and the highest temperature in a porous blockage. (author)

Exploring relationships of catheter-associated urinary tract infection and blockage in people with long-term indwelling urinary catheters.

Science.gov (United States)

Wilde, Mary H; McMahon, James M; Crean, Hugh F; Brasch, Judith

2017-09-01

To describe and explore relationships among catheter problems in long-term indwelling urinary catheter users, including excess healthcare use for treating catheter problems. Long-term urinary catheter users experience repeated problems with catheter-related urinary tract infection and blockage of the device, yet little has been reported of the patterns and relationships among relevant catheter variables. Secondary data analysis was conducted from a sample in a randomised clinical trial, using data from the entire sample of 202 persons over 12 months' participation. Descriptive statistics were used to characterise the sample over time. Zero-inflated negative binomial models were employed for logistic regressions to evaluate predictor variables of the presence/absence and frequencies of catheter-related urinary tract infection and blockage. Catheter-related urinary tract infection was marginally associated with catheter blockage. Problems reported at least once per person in the 12 months were as follows: catheter-related urinary tract infection 57%, blockage 34%, accidental dislodgment 28%, sediment 87%, leakage (bypassing) 67%, bladder spasms 59%, kinks/twists 42% and catheter pain 49%. Regression analysis demonstrated that bladder spasms were significantly related to catheter-related urinary tract infection and sediment amount, and catheter leakages were marginally significantly and positively related to catheter-related urinary tract infection. Frequencies of higher levels of sediment and catheter leakage were significantly associated with higher levels of blockage, and being female was associated with fewer blockages. Persons who need help with eating (more disabled) were also more likely to have blockages. Catheter-related urinary tract infection and blockage appear to be related and both are associated with additional healthcare expenditures. More research is needed to better understand how to prevent adverse catheter outcomes and patterns of problems in

Transcriptional blockages in a cell-free system by sequence-selective DNA alkylating agents.

Science.gov (United States)

Ferguson, L R; Liu, A P; Denny, W A; Cullinane, C; Talarico, T; Phillips, D R

2000-04-14

There is considerable interest in DNA sequence-selective DNA-binding drugs as potential inhibitors of gene expression. Five compounds with distinctly different base pair specificities were compared in their effects on the formation and elongation of the transcription complex from the lac UV5 promoter in a cell-free system. All were tested at drug levels which killed 90% of cells in a clonogenic survival assay. Cisplatin, a selective alkylator at purine residues, inhibited transcription, decreasing the full-length transcript, and causing blockage at a number of GG or AG sequences, making it probable that intrastrand crosslinks are the blocking lesions. A cyclopropylindoline known to be an A-specific alkylator also inhibited transcription, with blocks at adenines. The aniline mustard chlorambucil, that targets primarily G but also A sequences, was also effective in blocking the formation of full-length transcripts. It produced transcription blocks either at, or one base prior to, AA or GG sequences, suggesting that intrastrand crosslinks could again be involved. The non-alkylating DNA minor groove binder Hoechst 33342 (a bisbenzimidazole) blocked formation of the full-length transcript, but without creating specific blockage sites. A bisbenzimidazole-linked aniline mustard analogue was a more effective transcription inhibitor than either chlorambucil or Hoechst 33342, with different blockage sites occurring immediately as compared with 2 h after incubation. The blockages were either immediately prior to AA or GG residues, or four to five base pairs prior to such sites, a pattern not predicted from in vitro DNA-binding studies. Minor groove DNA-binding ligands are of particular interest as inhibitors of gene expression, since they have the potential ability to bind selectively to long sequences of DNA. The results suggest that the bisbenzimidazole-linked mustard does cause alkylation and transcription blockage at novel DNA sites. in addition to sites characteristic of

Closure Report for Corrective Action Unit 230: Area 22 Sewage Lagoons and Corrective Action Unit 320: Area 22 Desert Rock Airport Strainer Box Nevada Test Site, Nevada

Energy Technology Data Exchange (ETDEWEB)

D. S. Tobiason

2001-07-01

This Closure Report (CR) describes the remediation activities performed and the results of verification sampling conducted at Corrective Action Unit (CAU) 230, Area 22 Sewage Lagoons and CAU 320, Area 22 Desert Rock Airport Strainer Box. The CAU is currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO, 1996). The CAU is located in Area 22 of the Nevada Test Site (NTS) (Figure 1) and consists of the following Corrective Action Sites (CASs): 22-03-01- Sewage Lagoon (CAU 230); and 22-99-01- Strainer Box (CAU 320). Included with CAS 22-99-01 is a buried Imhoff tank and a sludge bed. These CAUs will be collectively referred to in this plan as the Area 22 Sewage Lagoons site. Site characterization activities were done during September 1999. Characterization of the manholes associated with the septic system leading to the Imhoff tank was done during March 2000. The results of the characterization presented in the Corrective Action Decision Document (CADD) indicated that only the sludge bed (CAS 22-99-01) contained constituents of concern (COC) above action levels and required remediation (U.S. Department of Energy, Nevada Operations Office [DOE/NV], 2000a).

Mechanical interaction of Engineered Cementitious Composite (ECC) reinforced with Fiber Reinforced Polymer (FRP) rebar in tensile loading

DEFF Research Database (Denmark)

Lárusson, Lárus Helgi; Fischer, Gregor; Jönsson, Jeppe

2010-01-01

This paper introduces a preliminary study of the composite interaction of Engineered Cementitious Composite (ECC), reinforced with Glass Fiber Reinforced Polymer (GFRP) rebar. The main topic of this paper will focus on the interaction of the two materials (ECC and GFRP) during axial loading......, particularly in post cracking phase of the concrete matrix. The experimental program carried out in this study examined composite behavior under monotonic and cyclic loading of the specimens in the elastic and inelastic deformation phases. The stiffness development of the composite during loading was evaluated...

Performance Tests for Bubble Blockage Device

International Nuclear Information System (INIS)

Ha, Kwang Soon; Wi, Kyung Jin; Park, Rae Joon; Wan, Han Seong

2014-01-01

Postulated severe core damage accidents have a high threat risk for the safety of human health and jeopardize the environment. Versatile measures have been suggested and applied to mitigate severe accidents in nuclear power plants. To improve the thermal margin for the severe accident measures in high-power reactors, engineered corium cooling systems involving boiling-induced two-phase natural circulation have been proposed for decay heat removal. A boiling-induced natural circulation flow is generated in a coolant path between a hot vessel wall and cold coolant reservoir. In general, it is possible for some bubbles to be entrained in the natural circulation loop. If some bubbles entrain in the liquid phase flow passage, flow instability may occur, that is, the natural circulation mass flow rate may be oscillated. A new device to block the entraining bubbles is proposed and verified using air-water test loop. To avoid bubbles entrained in the natural circulation flow loop, a new device was proposed and verified using an air-water test loop. The air injection and liquid circulation loop was prepared, and the tests for the bubble blockage devices were performed by varying the geometry and shape of the devices. The performance of the bubble blockage device was more effective as the area ratio of the inlet to the down-comer increased, and the device height decreased. If the device has a rim to generate a vortex zone, the bubbles will be most effectively blocked

Effects of thermohydraulics on clad ballooning, flow blockage and coolability in a LOCA

International Nuclear Information System (INIS)

Erbacher, F.J.; Neitzel, H.J.; Wiehr, K.

1983-01-01

Thermohydraulic boundary conditions have a dominating effect on clad ballooning, flow blockage and coolability: Increasing heat transfer to the fluid decreases the total circumferential strain; Countercurrent flow in a combined injection leads to a relatively small flow blockage; Burst claddings exhibit premature quenching. Differences in the test results obtained in several countries are mainly due to different thermohydraulic test conditions; all test data are consistent with the understanding elaborated within the REBEKA program. Core coolability in a LOCA can be maintained. (author)

Comparison of allele frequency for HLA-DR and HLA-DQ between patients with ECC and caries-free children

OpenAIRE

Bagherian A; Nematollahi H; Afshari J; Moheghi N

2008-01-01

Background: Early childhood caries (ECC) is one of the most common diseases of childhood. The etiology of ECC is multifactorial and both genetic and environmental factors play important roles in the pathogenesis of the disease. Genetic variations in the hosts may contribute to changes in the risk for dental caries. Genetic factors such as human leukocyte antigen (HLA) have recently been suggested as a predisposing factor. Aim: The aim of this study was to look for an association between HLA-D...

Factors predisposing to early childhood caries (ECC) in children of pre-school age in the city of Zagreb, Croatia.

Science.gov (United States)

Lulić-Dukić, O; Jurić, H; Dukić, W; Glavina, D

2001-06-01

The aim of this study was to investigate factors predisposing to early childhood caries (ECC) in pre-school children in the city of Zagreb, Croatia. The investigation was carried out on the sample of 145 children (77 boys and 68 girls) aged between 2 and 5 years, including clinical examination of dental status and survey on the habits among the parents. The overall prevalence of ECC was 30%: in girls it was 25%, and in boys 48%. The study on the risk factors was designed as a classic case-control study. The mean value of dmfs index among the cases amounted to 8.6, in comparison to 5.2 in the control group (pteeth-brushing habit after first 24 months did (p importance of early introduction of teeth-brushing and giving up the nightly consumption of sweet beverages in prevention of ECC.

A provably-secure ECC-based authentication scheme for wireless sensor networks.

Science.gov (United States)

Nam, Junghyun; Kim, Moonseong; Paik, Juryon; Lee, Youngsook; Won, Dongho

2014-11-06

A smart-card-based user authentication scheme for wireless sensor networks (in short, a SUA-WSN scheme) is designed to restrict access to the sensor data only to users who are in possession of both a smart card and the corresponding password. While a significant number of SUA-WSN schemes have been suggested in recent years, their intended security properties lack formal definitions and proofs in a widely-accepted model. One consequence is that SUA-WSN schemes insecure against various attacks have proliferated. In this paper, we devise a security model for the analysis of SUA-WSN schemes by extending the widely-accepted model of Bellare, Pointcheval and Rogaway (2000). Our model provides formal definitions of authenticated key exchange and user anonymity while capturing side-channel attacks, as well as other common attacks. We also propose a new SUA-WSN scheme based on elliptic curve cryptography (ECC), and prove its security properties in our extended model. To the best of our knowledge, our proposed scheme is the first SUA-WSN scheme that provably achieves both authenticated key exchange and user anonymity. Our scheme is also computationally competitive with other ECC-based (non-provably secure) schemes.

A Provably-Secure ECC-Based Authentication Scheme for Wireless Sensor Networks

Science.gov (United States)

Nam, Junghyun; Kim, Moonseong; Paik, Juryon; Lee, Youngsook; Won, Dongho

2014-01-01

A smart-card-based user authentication scheme for wireless sensor networks (in short, a SUA-WSN scheme) is designed to restrict access to the sensor data only to users who are in possession of both a smart card and the corresponding password. While a significant number of SUA-WSN schemes have been suggested in recent years, their intended security properties lack formal definitions and proofs in a widely-accepted model. One consequence is that SUA-WSN schemes insecure against various attacks have proliferated. In this paper, we devise a security model for the analysis of SUA-WSN schemes by extending the widely-accepted model of Bellare, Pointcheval and Rogaway (2000). Our model provides formal definitions of authenticated key exchange and user anonymity while capturing side-channel attacks, as well as other common attacks. We also propose a new SUA-WSN scheme based on elliptic curve cryptography (ECC), and prove its security properties in our extended model. To the best of our knowledge, our proposed scheme is the first SUA-WSN scheme that provably achieves both authenticated key exchange and user anonymity. Our scheme is also computationally competitive with other ECC-based (non-provably secure) schemes. PMID:25384009

A Provably-Secure ECC-Based Authentication Scheme for Wireless Sensor Networks

Directory of Open Access Journals (Sweden)

Junghyun Nam

2014-11-01

Full Text Available A smart-card-based user authentication scheme for wireless sensor networks (in short, a SUA-WSN scheme is designed to restrict access to the sensor data only to users who are in possession of both a smart card and the corresponding password. While a significant number of SUA-WSN schemes have been suggested in recent years, their intended security properties lack formal definitions and proofs in a widely-accepted model. One consequence is that SUA-WSN schemes insecure against various attacks have proliferated. In this paper, we devise a security model for the analysis of SUA-WSN schemes by extending the widely-accepted model of Bellare, Pointcheval and Rogaway (2000. Our model provides formal definitions of authenticated key exchange and user anonymity while capturing side-channel attacks, as well as other common attacks. We also propose a new SUA-WSN scheme based on elliptic curve cryptography (ECC, and prove its security properties in our extended model. To the best of our knowledge, our proposed scheme is the first SUA-WSN scheme that provably achieves both authenticated key exchange and user anonymity. Our scheme is also computationally competitive with other ECC-based (non-provably secure schemes.

Closure Report for Corrective Action Unit 230: Area 22 Sewage Lagoons and Corrective Action Unit 320: Area 22 Desert Rock Airport Strainer Box Nevada Test Site, Nevada; TOPICAL

International Nuclear Information System (INIS)

D. S. Tobiason

2001-01-01

This Closure Report (CR) describes the remediation activities performed and the results of verification sampling conducted at Corrective Action Unit (CAU) 230, Area 22 Sewage Lagoons and CAU 320, Area 22 Desert Rock Airport Strainer Box. The CAU is currently listed in Appendix III of the Federal Facility Agreement and Consent Order (FFACO, 1996). The CAU is located in Area 22 of the Nevada Test Site (NTS) (Figure 1) and consists of the following Corrective Action Sites (CASs): 22-03-01- Sewage Lagoon (CAU 230); and 22-99-01- Strainer Box (CAU 320). Included with CAS 22-99-01 is a buried Imhoff tank and a sludge bed. These CAUs will be collectively referred to in this plan as the Area 22 Sewage Lagoons site. Site characterization activities were done during September 1999. Characterization of the manholes associated with the septic system leading to the Imhoff tank was done during March 2000. The results of the characterization presented in the Corrective Action Decision Document (CADD) indicated that only the sludge bed (CAS 22-99-01) contained constituents of concern (COC) above action levels and required remediation (U.S. Department of Energy, Nevada Operations Office[DOE/NV], 2000a)

Assessment of some interfacial shear correlations in a model of ECC bypass flow in PWR reactor downcomer

International Nuclear Information System (INIS)

Popov, N.K.; Rohatgi, U.S.

1987-01-01

The bypass/refill process in the PWR reactor downcomer, following a large rupture of a cold leg coolant supply pipe, is a complicated thermo-hydraulic two-phase flow phenomenon. Mathematical modeling of such phenomena is always accompanied with a difficult task of selection of suitable constitutive correlations. In a typically hydrodynamic phenomenon, like ECC refill process of the reactor lower plenum is considered, the phasic interfacial friction is the most influential constitutive correlation. Therefore, assessment of the well-known widely-used interfacial friction constitutive correlations in the model of ECC bypass/refill process, is the subject of this paper

The E.C.C. programme in the field of radioactive wastes

International Nuclear Information System (INIS)

Orlowski, S.

1976-01-01

After a description of the aims of the E.C.C. in the field of radioactive wastes, the contents and the structure of the programme developed for this purpose as well as its time schedule and financing, are presented. The state of work progress and the first results of the actions taken, whose application is marked by an active cooperation of numerous national experts are quoted [fr

PHEBUS FPT-1 simulation by using MELCOR and primary blockage model exploration

Energy Technology Data Exchange (ETDEWEB)

Wang, Jun [Institite of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); College of Engineering, The University of Wisconsin-Madison, Madison 53706 (United States); Wang, Chen [College of Engineering, The University of Wisconsin-Madison, Madison 53706 (United States); Department of Engineering Physics, Tsinghua University, Beijing 100084 (China); Corradini, Michael L.; Haskin, Troy [College of Engineering, The University of Wisconsin-Madison, Madison 53706 (United States); Tian, Wenxi; Su, Guanghui [Institite of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China); Qiu, Suizheng, E-mail: szqiu@mail.xjtu.edu.cn [Institite of Nuclear Science and Technology, Xi’an Jiaotong University, Xi’an 710049 (China)

2016-10-15

Highlights: • Flow channel blockage model is expected to be the key parameter for hydrogen generation calculation. • Flow channel blockage situation is studied in this work. • MELCOR is used as the tool, and PHEBUS FPT1 is used as benchmark. • Model sensitivity analysis on hydrogen generation will be done in next step. - Abstract: Recently, MAAP and MELCOR research teams completed a set of accident simulations to reconstruct the Fukushima-Daiichi accident in order to better understand severe accident progression. One result from this work is that the predicted hydrogen generation in MELCOR is notably more than that in MAAP. The fuel rod degradation process (i.e., debris formation and blockage models) may be responsible for this difference and opportunity exists to understand the key reasons for the difference. To examine this hypothesis, in this paper, the PHEBUS FPT1 experiment is selected as a benchmark test and MELCOR is used as the analysis tool. MELCOR calculation results are compared with PHEBUS FPT1 data to verify our model. Based on the validation of a nominal MELCOR simulation of the FPT1 test, we use the volume fractions of each component to visualize the debris-blockage geometric arrangement for PHEBUS FPT1 as the fuel degradation event proceeds. Cloud figures for the volume fractions of each component such as flow volume fraction, cladding volume fraction, fuel rod volume fraction, supporting material volume fraction, non-supporting material volume fraction and debris bed porosity fraction are shown in this paper. The results provide us with a visualized approach for improving our understanding of core degradation.

PHEBUS FPT-1 simulation by using MELCOR and primary blockage model exploration

International Nuclear Information System (INIS)

Wang, Jun; Wang, Chen; Corradini, Michael L.; Haskin, Troy; Tian, Wenxi; Su, Guanghui; Qiu, Suizheng

2016-01-01

Highlights: • Flow channel blockage model is expected to be the key parameter for hydrogen generation calculation. • Flow channel blockage situation is studied in this work. • MELCOR is used as the tool, and PHEBUS FPT1 is used as benchmark. • Model sensitivity analysis on hydrogen generation will be done in next step. - Abstract: Recently, MAAP and MELCOR research teams completed a set of accident simulations to reconstruct the Fukushima-Daiichi accident in order to better understand severe accident progression. One result from this work is that the predicted hydrogen generation in MELCOR is notably more than that in MAAP. The fuel rod degradation process (i.e., debris formation and blockage models) may be responsible for this difference and opportunity exists to understand the key reasons for the difference. To examine this hypothesis, in this paper, the PHEBUS FPT1 experiment is selected as a benchmark test and MELCOR is used as the analysis tool. MELCOR calculation results are compared with PHEBUS FPT1 data to verify our model. Based on the validation of a nominal MELCOR simulation of the FPT1 test, we use the volume fractions of each component to visualize the debris-blockage geometric arrangement for PHEBUS FPT1 as the fuel degradation event proceeds. Cloud figures for the volume fractions of each component such as flow volume fraction, cladding volume fraction, fuel rod volume fraction, supporting material volume fraction, non-supporting material volume fraction and debris bed porosity fraction are shown in this paper. The results provide us with a visualized approach for improving our understanding of core degradation.

Modifying the ECC-based grouping-proof RFID system to increase inpatient medication safety.

Science.gov (United States)

Ko, Wen-Tsai; Chiou, Shin-Yan; Lu, Erl-Huei; Chang, Henry Ker-Chang

2014-09-01

RFID technology is increasingly used in applications that require tracking, identification, and authentication. It attaches RFID-readable tags to objects for identification and execution of specific RFID-enabled applications. Recently, research has focused on the use of grouping-proofs for preserving privacy in RFID applications, wherein a proof of two or more tags must be simultaneously scanned. In 2010, a privacy-preserving grouping proof protocol for RFID based on ECC in public-key cryptosystem was proposed but was shown to be vulnerable to tracking attacks. A proposed enhancement protocol was also shown to have defects which prevented proper execution. In 2012, Lin et al. proposed a more efficient RFID ECC-based grouping proof protocol to promote inpatient medication safety. However, we found this protocol is also vulnerable to tracking and impersonation attacks. We then propose a secure privacy-preserving RFID grouping proof protocol for inpatient medication safety and demonstrate its resistance to such attacks.

Strategies for safe exploitation of fresh water through multi-strainer skimming wells in saline groundwater areas

International Nuclear Information System (INIS)

Alam, M.M.; Jaffery, H.M.; Hanif, M.

2005-01-01

Indus Basin of Pakistan to develop strategies for the safe exploitation of fresh upper groundwater layer through multi-strainer skimming wells in the areas having deeper saline groundwater. Results of detailed investigations are given in this paper. A methodology was designed for investigations and to study the movement of saline-fresh water interface. For this purpose deep observation wells were installed and water samples from various depths over a period of wells operational hours have been collected. Water quality of these samples was tested to evaluate the movement of saline-fresh water interface. Results indicated that there exists a relatively fresh water aquifer above the depth of 20m. Relatively impervious layer and clay lenses of variable thickness exists at various locations in the area. There is relatively less contribution from the lower aquifer as compared to the lateral movement of water to the well above the impervious layers. The skimming wells were operated for a different number of hours and water quality evaluated. The results show that the quality and quantity of the pumped groundwater can be improved with intermittent pumping for 4-6 hours per day under drought conditions and recovery of the water-table is quick. Moreover, the intermittent pumping maintained a minimum suction lift that helped get a relatively good discharge. Continuous long term pumping proved to be dangerous which can cause saline water intrusion. It is recommended to avoid long term pumping of skimming wells. Intermittent short hours operation can be helpful for safe exploitation of fresh water and make skimming well operation more cost effective. It is further added that 4-6 strainers make these skimming wells cost effective as compared to having a large number of strainers in a skimming well. (author)

Three-Dimensional, Numerical Investigation of Flow and Heat Transfer in Rectangular Channels Subject to Partial Blockage

KAUST Repository

Salama, Amgad; El-Amin, Mohamed; Sun, Shuyu

2014-01-01

Numerical simulation of flow and heat transfer in two adjacent channels is conducted with one of the channels partially blocked. This system simulates typical channels of a material testing reactor. The blockage is assumed due to the buckling of one of the channel plates inward along its width. The blockage ratio considered in this work is defined as the ratio between the cross-sectional area of the blocked and the unblocked channel. In this work, we consider a blockage ratio of approximately 40%. However, the blockage is different along the width of the channel, ranging from 0% at the end of the channel to 90% in the middle. The channel walls are sandwiching volumetric heat sources that vary spatially as chopped cosine functions. Interesting patterns are highlighted and investigated. The reduction in the flow area of one channel results in the flow redistributing among the two channels according to the changes in their hydraulic conductivities. The results of the numerical simulations show that the maximum wall temperature in the blocked channel is well below the boiling temperature at the operating pressure.

Three-Dimensional, Numerical Investigation of Flow and Heat Transfer in Rectangular Channels Subject to Partial Blockage

KAUST Repository

Salama, Amgad

2014-08-25

Numerical simulation of flow and heat transfer in two adjacent channels is conducted with one of the channels partially blocked. This system simulates typical channels of a material testing reactor. The blockage is assumed due to the buckling of one of the channel plates inward along its width. The blockage ratio considered in this work is defined as the ratio between the cross-sectional area of the blocked and the unblocked channel. In this work, we consider a blockage ratio of approximately 40%. However, the blockage is different along the width of the channel, ranging from 0% at the end of the channel to 90% in the middle. The channel walls are sandwiching volumetric heat sources that vary spatially as chopped cosine functions. Interesting patterns are highlighted and investigated. The reduction in the flow area of one channel results in the flow redistributing among the two channels according to the changes in their hydraulic conductivities. The results of the numerical simulations show that the maximum wall temperature in the blocked channel is well below the boiling temperature at the operating pressure.

A model of gas cavity breakup behind a blockage in fast breeder reactor subassembly geometry

International Nuclear Information System (INIS)

Fukuzawa, Y.

1980-05-01

A semi-empirical model has been developed to describe the transient behaviour of a gas cavity due to breakup behind a blockage in Liquid Metal Fast Breeder Reactor subassembly geometry. The main mechanisms assumed for gas cavity breakup in the present model are as follows: The gas cavity is broken up by the pressure fluctuation at the interface due to turbulence in the liquid. The centrifugal force on the liquid opposes breakup. The model is able to describe experimental results on the transient behaviour of a gas cavity due to breakup after the termination of gas injection. On the basis of the present model the residence time of a gas cavity behind a blockage in sodium is predicted and the dependence of the residence time on blockage size is discussed. (orig.) [de

Physiological blockage in plants in response to postharvest stress ...

African Journals Online (AJOL)

Flowers have been designed primarily for cutting because of the diversity of shapes, colors and also durability. However, ornamental plants are used in floral arrangements in vases and have limited shelf-life. Thus, this study showed that one of the factors contributing to this limitation is the physiological blockage that occurs ...

Preliminary validation of the MATRA-LMR-FB code for the flow blockage in a subassembly

International Nuclear Information System (INIS)

Jeong, H. Y.; Ha, K. S.; Kwon, Y. M.; Chang, W. P.; Lee, Y. B.; Heo, S.

2005-01-01

To analyze the flow blockage in a subassembly of a Liquid Metal-cooled Reactor (LMR), the MATRA-LMR-FB code has been developed and validated for the existing experimental data. Compared to the MATRA-LMR code, which had been successfully applied for the core thermal-hydraulic design of KALIMER, the MATRA-LMR-FB code includes some advanced modeling features. Firstly, the Distributed Resistance Model (DRM), which enables a very accurate description of the effects of wire-wrap and blockage in a flow path, is developed for the MATRA-LMR-FB code. Secondly, the hybrid difference method is used to minimize the numerical diffusion especially at the low flow region such as recirculating wakes after blockage. In addition, the code is equipped with various turbulent mixing models to describe the active mixing due to the turbulent motions as accurate as possible. For the validation of the MATRA-LMR-FB code the ORNL THORS test and KOS 169-pin test are analyzed. Based on the analysis results for the temperature data, the accuracy of the code is evaluated quantitatively. The MATRA-LMR-FB code predicts very accurately the exit temperatures measured in the subassembly with wire-wrap. However, the predicted temperatures for the experiment with spacer grid show some deviations from the measured. To enhance the accuracy of the MATRA-LMR-FB for the flow path with grid spacers, it is suggested to improve the models for pressure loss due to spacer grid and the modeling method for blockage itself. The developed MATRA-LMR-FB code is evaluated to be applied to the flow blockage analysis of KALIMER-600 which adopts the wire-wrapped subassemblies

Development of a wall-shear-stress sensor and measurements in mini-channels with partial blockages

Science.gov (United States)

Afara, Samer; Medvescek, James; Mydlarski, Laurent; Baliga, Bantwal R.; MacDonald, Mark

2014-05-01

The design, construction, operation and validation of a wall-shear-stress sensor, and measurements obtained using this sensor in air flows downstream of partial blockages in a mini-channel are presented. The sensor consisted of a hot wire mounted over a small rectangular slot and operated using a constant-temperature anemometer. It was used to investigate flows similar to those within the mini-channels inside notebook computers. The overall goal of the present work was to develop a sensor suitable for measurements of the wall-shear stress in such flows, which can be used to validate corresponding numerical simulations, as the latter are known to be often surprisingly inaccurate. To this end, measurements of the wall-shear stress, and the corresponding statistical moments and power spectral densities, were obtained at different distances downstream of the partial blockage, with blockage ratios of 39.7, 59.2, and 76.3 %. The Reynolds number (based on average velocity and hydraulic diameter) ranged from 100 to 900. The results confirmed the presence of unsteadiness, separation, reattachment, and laminar-turbulent transition in the ostensibly laminar flow of air in mini-channels with partial blockages. The present results demonstrate why accurate numerical predictions of cooling air flows in laptop and notebook computers remain a challenging task.

Upon local blockage formations in LMFBR fuel rod bundles with wire-wrapped spacers

International Nuclear Information System (INIS)

Minden, C. v.; Schultheiss, G.F.

1982-01-01

A theoretical and experimental study, to improve understanding of local particle depositions in a wire-wrapped LMFBR fuel bundle, has been performed. Theoretical considerations show, that a preferentially axial process of particle depositions occurs. The experiments confirm this and clarify that the blockages arise near the particle source and settle at the spatially arranged minimum gaps in the bundle. The results suggest that, considering flow reduction, cooling and DND-detection, such fuel particle blockages are less dangerous. With reference to these safety-relevant factors, wire-wrapped LMFBR fuel bundles seem to gain advantages compared to the grid design. (orig.) [de

Conclusions Drawn from the Investigation of LOCA-Induced Insulation Debris Generation and its Impact on Emergency Core Cooling (ECC) at German NPPs - Approach Taken by / Perspective of The German TSO (TuV)

International Nuclear Information System (INIS)

Huber, J.

2004-01-01

Initiated by the Barsebaeck incident in 1992 and the following activities related to the LOCA-induced insulation debris generation and its impact on emergency core cooling, investigations on German PWRs and BWRs were performed in these areas. The investigations on the German BWRs were carried out in detail immediately after the Barsebaeck incident in the years 1992 through 1994. Detailed investigations on the German PWRs started after the issue of the OECD report in 1996. Therefore the investigations on the impact of LOCA-induced insulation debris generation on strainer plugging carried out in Germany in the last years were focused mainly on the German PWRs. In the framework of these investigations of the German PWRs, the relevant parameters and phenomena were investigated in detail by the plant owners in the years from 1997 through 1999. The results were summarised in reports for each plant. The main results of the investigations conducted by the plant owners were that the plant owners considered backfitting in German PWRs is not necessary to guarantee emergency core cooling following a LOCA with insulation debris generation. As the technical support organisation for the German Bavarian and Hessian state authority, the TUV Suddeutschland was called upon to examine these investigations and the conclusions drawn by the plant owners. We compared each of the parameters and phenomena against the state of knowledge. The results of our examination in 1999 showed that the investigations of the plant owners were generally correct, but we stated also, that due to existing uncertainties, further investigations are necessary to validate the results. To meet these demands, the plant owners installed a working group for planning and performing newer, more realistic large-scale experiments (scaling factor 1:4) to investigate the transport mechanism of the insulation material within the containment sump, the head loss at the strainers and to estimate the amount of insulation

ECCE Toolkit: Prototyping Sensor-Based Interaction

Directory of Open Access Journals (Sweden)

Andrea Bellucci

2017-02-01

Full Text Available Building and exploring physical user interfaces requires high technical skills and hours of specialized work. The behavior of multiple devices with heterogeneous input/output channels and connectivity has to be programmed in a context where not only the software interface matters, but also the hardware components are critical (e.g., sensors and actuators. Prototyping physical interaction is hindered by the challenges of: (1 programming interactions among physical sensors/actuators and digital interfaces; (2 implementing functionality for different platforms in different programming languages; and (3 building custom electronic-incorporated objects. We present ECCE (Entities, Components, Couplings and Ecosystems, a toolkit for non-programmers that copes with these issues by abstracting from low-level implementations, thus lowering the complexity of prototyping small-scale, sensor-based physical interfaces to support the design process. A user evaluation provides insights and use cases of the kind of applications that can be developed with the toolkit.

Identification of partial blockages in pipelines using genetic algorithms

Indian Academy of Sciences (India)

A methodology to identify the partial blockages in a simple pipeline using genetic algorithms for non-harmonic flows is presented in this paper. A sinusoidal flow generated by the periodic on-and-off operation of a valve at the outlet is investigated in the time domain and it is observed that pressure variation at the valve is ...

Experimental study of blockage of monochromatic waves by counter currents

NARCIS (Netherlands)

Suastika, I.K.

1999-01-01

Blockage of waves by a current can occur if waves are propagating on a spatially varying opposing current in which the velocity is increasing in the wave propagation direction. The ongoing waves become shorter and steeper while they are propagating against the current. Blocking occurs at the

Factors Predisposing to Early Childhood Caries (ECC) in Children of Pre-School Age in the City of Zagreb, Croatia

OpenAIRE

Lulić-Dukić, O.; Jurić, H.; Dukić, W.; Glavina, D.

2001-01-01

The aim of this study was to investigate factors predisposing to early childhood caries (ECC) in pre-school children in the city of Zagreb, Croatia. The investigation was carried out on the sample of 145 children (77 boys and 68 girls) aged between 2 and 5 years, including clinical examination of dental status and survey on the habits among the parents. The overall prevalence of ECC was 30%: in girls it was 25%, and in boys 48%. The study on the risk factors was designed as a c...

Design Development of SMART ECC Water Asymmetric Two-phase choking test facility

Energy Technology Data Exchange (ETDEWEB)

Cho, Young Il; Cho, Seok; Ko, Yung Joo; Shin, Yong Cheol; Kwon, Tae Soon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2011-05-15

SMART pressurized water reactor type is different from the existing integral NSSS commercial pressurized water reactor system which is equipped with the main features. In addition RCS piping is removed and the feature of the SBLOCA is a major design break accident. The TASS / SMR code is analyzed SMART SBLOCA. In order to verify analysis code, SMART analysis for verification of conservatism is promoting using data for experiments with Integral Effect Test and Separate Effect. In this paper, the design feature of the SWAT (SMART ECC Water Asymmetric Two-phase choking test facility) is described. SWAT is linearly reduced to a 1/5 ratio while the geometrical shape is conserved. In major shape of SMART ECC injection performance test, distortions which caused by gravitational effects are minimized. Because both the emergency core cooling water injection nozzle height and the break nozzle height match the RCP Suction Nozzle height in test section of the main forms. The main part of the test section is SG-side upper down-comer. The boundary conditions are saturated steam and water flow condition and drain flow rate to control the collapsed water level in the down-comer

Temperature fluctuation of sodium in annular flow channel heated by single-pin with blockage

International Nuclear Information System (INIS)

Miyazaki, Keiji; Kimura, Jiro; Ogawa, Masuro; Okada, Toshio

1978-01-01

Root mean square (RMS) value and power spectral density (PSD) of temperature fluctuation were measured with use of forced-circulating sodium in an annular channel (6.5 mm I.D., 20mm O.D.) with concentric disk to simulate blockage (about 80%) of sodium flow. The experimental range of the heat flux was 40 -- 150 W/cm 2 and the bulk flow velocity 0.14--0.41m/sec (Re=7.7x10 3 --2.3x10 4 ) under a temperature of 500--800 0 C. The RMS value measured at the exit of heating section (150mm downstream from the blockage) is larger by a factor of 2 -- 3 than that in the wake (10 -- 20mm downstream from the blockage), marking a few deg.C for a heat flux of 105W/cm 2 and a flow velocity of 0.27m/sec. The RMS value is proportional to the wall-to-bulk-fluid temperature difference in heat transfer, presenting the similar dependence on the heat flux and flow velocity. The fluctuations of temperature are greatly attenuated in the upper unheated section where the radial temperature gradient is absent, and consequently it is suggested that the fluctuations of temperature should be caused by the local turbulence of flow, such as a vortex street due to blockage in the present experiment, under the presence of large gradient of temperature near the heating surface. (auth.)

Ionic charge transport between blockages: Sodium cation conduction in freshly excised bulk brain tissue

Energy Technology Data Exchange (ETDEWEB)

Emin, David, E-mail: emin@unm.edu [Department of Physics and Astronomy, University of New Mexico, Albuquerque, NM 87131 (United States); Akhtari, Massoud [Semple Institutes for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 (United States); Ellingson, B. M. [Department of Radiology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 (United States); Mathern, G. W. [Department of Neurosurgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 (United States)

2015-08-15

We analyze the transient-dc and frequency-dependent electrical conductivities between blocking electrodes. We extend this analysis to measurements of ions’ transport in freshly excised bulk samples of human brain tissue whose complex cellular structure produces blockages. The associated ionic charge-carrier density and diffusivity are consistent with local values for sodium cations determined non-invasively in brain tissue by MRI (NMR) and diffusion-MRI (spin-echo NMR). The characteristic separation between blockages, about 450 microns, is very much shorter than that found for sodium-doped gel proxies for brain tissue, >1 cm.

A new paradigm for the reversible blockage of whisker sensory transmission.

Science.gov (United States)

Gener, Thomas; Reig, Ramon; Sanchez-Vives, Maria V

2009-01-30

The objective of this study was to explore a paradigm that would allow a temporary deprivation of whisker information lasting for a few hours. An additional requirement was to be non-invasive in order to be usable in awake chronically implanted rats without inducing stress. With that aim, electrophysiological recordings from the barrel cortex of anesthetized rats were obtained. The pressure of an air-puff (5-10 ms) delivered to the whiskers was adjusted to evoke a consistent response of around 100 microV (extracellular) or approximately 5 mV (intracellular) in the contralateral cortex. Lidocaine was then locally applied in different forms (cream, local injection, aerosol, drops) and concentrations (2-10%) to the base of the whiskers. The stimulus-induced response was monitored once every 5s for several hours (3-6h) in order to characterize its course of action. Local injection of lidocaine induced the fastest and most complete blockage, but was ruled out for being invasive. Out of the remaining forms of application, a lidocaine drop (0.4 ml, 10%) to the base of the whiskers was found to induce a reliable blockage (to an average 9% the original response). The maximum effect was reached after 150-200 min, and the response was totally recovered approximately 300 min after lidocaine application. This characterization should be useful to induce an efficient, short term and reversible blockage of whisker sensory transmission in both anesthetized and awake preparations, while not causing stress in an awake animal.

Experimental results of the SMART ECC injection performance with reduced scale of test facility

Energy Technology Data Exchange (ETDEWEB)

Cho, Young Il; Cho, Seok; Ko, Yung Joo; Shin, Yong Cheol; Kwon, Tae Soon [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2011-05-15

SMART pressurized water reactor type is different from the existing integral NSSS commercial pressurized water reactor system which is equipped with the main features. In addition, RCS piping is removed and the feature of the SBLOCA is a major design break accident. SWAT (SMART ECC Water Asymmetric Two-phase choking test facility) test facility is to simulate the 2 inch SBLOCA of the SMART using with reduced scale. The Test was performed to produce experimental data for the validation of the TASS/SMR-S thermal hydraulic analysis code, and to investigate the related thermal hydraulic phenomena in the down-comer region during the 2 inch SBLOCA of the safety inject line. The particular phenomena for the observation are ECC bypass and multi-dimensional flow characteristics to verify the effectiveness and performance of the safety injection system. In this paper, the corresponding steady state test conditions, including initial and boundary conditions along with major measuring parameters, and related experimental results were described

Adapted ECC ozonesonde for long-duration flights aboard boundary-layer pressurised balloons

Science.gov (United States)

Gheusi, François; Durand, Pierre; Verdier, Nicolas; Dulac, François; Attié, Jean-Luc; Commun, Philippe; Barret, Brice; Basdevant, Claude; Clenet, Antoine; Derrien, Solène; Doerenbecher, Alexis; El Amraoui, Laaziz; Fontaine, Alain; Hache, Emeric; Jambert, Corinne; Jaumouillé, Elodie; Meyerfeld, Yves; Roblou, Laurent; Tocquer, Flore

2016-12-01

Since the 1970s, the French space agency CNES has developed boundary-layer pressurised balloons (BLPBs) with the capability to transport lightweight scientific payloads at isopycnic level and offer a quasi-Lagrangian sampling of the lower atmosphere over very long distances and durations (up to several weeks).Electrochemical concentration cell (ECC) ozonesondes are widely used under small sounding balloons. However, their autonomy is limited to a few hours owing to power consumption and electrolyte evaporation. An adaptation of the ECC sonde has been developed specifically for long-duration BLPB flights. Compared to conventional ECC sondes, the main feature is the possibility of programming periodic measurement sequences (with possible remote control during the flight). To increase the ozonesonde autonomy, the strategy has been adopted of short measurement sequences (2-3 min) regularly spaced in time (e.g. every 15 min). The rest of the time, the sonde pump is turned off. Results of preliminary ground-based tests are first presented. In particular, the sonde was able to provide correct ozone concentrations against a reference UV-absorption ozone analyser every 15 min for 4 days. Then we illustrate results from 16 BLBP flights launched over the western Mediterranean during three summer field campaigns of the ChArMEx project (http://charmex.lsce.ipsl.fr): TRAQA in 2012, and ADRIMED and SAFMED in 2013. BLPB drifting altitudes were in the range 0.25-3.2 km. The longest flight lasted more than 32 h and covered more than 1000 km. Satisfactory data were obtained when compared to independent ozone measurements close in space and time. The quasi-Lagrangian measurements allowed a first look at ozone diurnal evolution in the marine boundary layer as well as in the lower free troposphere. During some flight segments, there was indication of photochemical ozone production in the marine boundary layer or even in the free troposphere, at rates ranging from 1 to 2 ppbv h -1, which

Effects of sleeve blockages on axial velocity and intensity of turbulence in an unheated 7 x 7 rod bundle

International Nuclear Information System (INIS)

Creer, J.M.; Rowe, D.S.; Bates, J.M.; Sutey, A.M.

1976-01-01

An experimental study is described which was performed to investigate the turbulent flow phenomena near postulated sleeve blockages in a model nuclear fuel rod bundle. The sleeve blockages were characteristic of fuel clad ''swelling'' or ''ballooning'' which could occur during loss-of-coolant accidents (LOCA) in pressurized water reactors. The study was conducted to provide information relative to the flow phenomena near postulated blockages to support detailed safety analyses of LOCAs. The results of the study are especially useful for verification of the hydraulic treatment of reactor core computer programs such as COBRA

MICROORGANISMS FOUND IN SECONDARY CATARACT MATERIAL OF ECCE PATIENTS, A STUDY WITH SEM AND TEM

NARCIS (Netherlands)

KALICHARAN, D; JONGEBLOED, WL; LOS, LI; WORST, JGF

1993-01-01

Globular secondary cataract material, removed from 24 patients with ECCE after ophthalmic cleaning of the anterior capsule, were investigated with SEM and TEM. Besides spherical, somewhat oval shaped bodies of various shape and size comparable with those found in cataractous lenses, (an)aerobic

Molten Fuel Mass Assessment for Channel Flow Blockage Event in CANDU6

International Nuclear Information System (INIS)

Lee, Kwang Ho; Kim, Yong Bae; Choi, Hoon; Park, Dong Hwan

2011-01-01

In CANDU6, a fuel channel flow blockage causes a sudden reduction of flow through the blocked channel. Depending on the severity of the blockage, the reduced flow through the channel can result in severe heat up of the fuel, hence possibly leading to pressure tube and calandria tube failure. If the calandria tube does not fail the fuel and sheath would continue to heat up, and ultimately melting could occur. Eventually, molten material runs down onto the pressure tube. Even a thin layer of molten material in contact with the pressure tube causes the pressure tube and calandreia tube to heat up rapidly. The thermal transient is so rapid that failure temperatures are reached quickly. After channel failure, the contents of the channel, consisting of superheated coolant, fission products and possibly overheated of molten fuel, are rapidly discharged into the moderator. Fuel discharged into the moderator is quenched and cooled. The rapid discharge of hot fuel and coolant into the calandria causes the moderator pressure and temperature to increase, which may cause damage to some in-core components. Thus, the assessment results of molten fuel mass are inputs to the in-core damage analysis. In this paper, the analysis methodology and results of molten fuel mass assessment for the channel flow blockage event are presented

Blockage effects on viscous fluid flow and heat transfer past a magnetic obstacle in a duct

International Nuclear Information System (INIS)

Zhang Xi-Dong; Huang Hu-Lin

2013-01-01

The effect of lateral walls on fluid flow and heat transfer is investigated when a fluid passes a magnetic obstacle. The blockage ratio β that represents the ratio between the width of external magnet M y and the spanwise width L y is employed to depict the effect. The finite volume method (FVM) based on the PISO algorithm is applied for the blockage ratios of 0.2, 0.3, and 0.4. The results show that the value of Strouhal number St increases as the blockage ratio β increases, and for small β, the variation of St is very small when the interaction parameter and Reynolds number are increasing. Moreover, the cross-stream mixing induced by the magnetic obstacle can enhance the wall-heat transfer and the maximum value of the overall heat transfer increment is about 50.5%

Empirical investigation of wind farm blockage effects in Horn Rev 1 offshore wind farm

DEFF Research Database (Denmark)

Mitraszewski, Karol; Hansen, Kurt Schaldemose; Nygaard, Nicolai

We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds and stabi......We present an empirical study of wind farm blockage effects based on Horns Rev 1 SCADA data. The mean inflow non-uniformities in wind speed are analyzed by calculating the mean power outputs of turbines located along the outer edges of the farm for different wind directions, wind speeds...

Combined group ECC protection and subgroup parity protection

Science.gov (United States)

Gara, Alan G.; Chen, Dong; Heidelberger, Philip; Ohmacht, Martin

2013-06-18

A method and system are disclosed for providing combined error code protection and subgroup parity protection for a given group of n bits. The method comprises the steps of identifying a number, m, of redundant bits for said error protection; and constructing a matrix P, wherein multiplying said given group of n bits with P produces m redundant error correction code (ECC) protection bits, and two columns of P provide parity protection for subgroups of said given group of n bits. In the preferred embodiment of the invention, the matrix P is constructed by generating permutations of m bit wide vectors with three or more, but an odd number of, elements with value one and the other elements with value zero; and assigning said vectors to rows of the matrix P.

Comprehensive Oral Health Care to Reduce the Incidence of Severe Early Childhood Caries (s-ECC) in Urban China.

Science.gov (United States)

Si, Yan; Guo, Yan; Yuan, Chao; Xu, Tao; Zheng, Shu Guo

2016-03-01

To explore the effectiveness of comprehensive oral health care to reduce the caries incidence for children with severe early childhood caries (s-ECC) in an urban area in China. A total of 357 children aged 3 to 4 years old and diagnosed with s-ECC were recruited in this randomised controlled, single-blinded clinical trial for 1 year. Children of two different kindergarten classes were enrolled in this study and randomly divided into a test group (205 children) and a control group (152 children). The test group received comprehensive oral health care, which included: oral health examination, oral health education, topical fluoride application and dental treatment, and the children in the control group only received the oral health examination. The evaluation of the oral health questionnaire for parents was also performed. An evaluation was carried out at the time of recruitment and 1 year later to explore the effectiveness of the comprehensive oral health care model. The differences in decayed teeth (dt), decayed tooth surfaces (ds), filled teeth (ft), filled tooth surfaces (fs) and the ratio of ft /(dt + ft) between the two groups were statistically significant (P comprehensive oral health care program reduces and prevents caries amongst children with s-ECC.

Prosthetic Oral Rehabilitation of a Child With S-ECC: A Case Report with Histopathologic Analysis.

Science.gov (United States)

Tannure, P N; Moraes, G G; Borba, McU; Abrahão, A; Andrade, Mtrc; Fidalgo, Tks

2015-01-01

The aim of this case report is to describe the treatment planning of a young child with severe early childhood caries (S-ECC) as well as the prosthetic rehabilitation technique. A 3-year-old female child was referred to the pediatric dentistry clinic with the chief complaint of tooth pain, difficulty in eating and recurrent hospitalizations caused by dental infections. The mother reported intermittent episodes of fever and recurrent swelling of child's face. The girl presented angular cheilitis and was referred to a dietitian. The treatment plain consisted on a behavior changes in oral hygiene habits, exodontias of all primary teeth and oral rehabilitation with a prosthesis. The extracted teeth with periapical lesions were submitted to histopathologic analysis (hematoxilin and eosin staining) and revealed an inflammatory infiltrate. The aesthetic requirement of children with S-ECC has been a challenge to pediatric dentists. In the present case, the oral rehabilitation provided for the children better aesthetic, nutrition, phonation, and functional conditions.

Complete genome sequences of Escherichia coli strains 1303 and ECC-1470 isolated from bovine mastitis

NARCIS (Netherlands)

Leimbach, Andreas; Poehlein, Anja; Witten, Anika; Scheutz, Flemming; Schukken, Ynte|info:eu-repo/dai/nl/075051907; Daniel, Rolf; Dobrindt, Ulrich

2016-01-01

Escherichia coli is the leading causative agent of acute bovine mastitis. Here, we report the complete genome sequence of E. coli O70:H32 strain 1303, isolated from an acute case of bovine mastitis, and E. coli Ont:Hnt strain ECC-1470, isolated from a persistent infection.

Effects of the blockage ratio of a valve disk on loss coefficient in a butterfly valve

International Nuclear Information System (INIS)

Rho, Hyung Joon; Lee, Jee Keun; Choi, Hee Joo

2008-01-01

The loss coefficient of the butterfly valve which allows partial opening of the valve at closed position and is applicable to the small-sized pipe system with the diameter of 1 inch was measured for the variation of the valve disk blockage ratio. Two different types of the valve disk configuration to adjust the blockage ratio were considered. One was the solid type valve disk of which the diameter was changed into the smaller size rather than the pipe diameter, and the other was the perforate type valve disk on which some holes were perforated. The results from two types of valve disk were compared to identify their characteristics in the loss coefficient distributions. The loss coefficient and the controllable angle of the valve disk were decreased exponentially with the decrease of the blockage ratio. In addition, the perforate valve disk had the effect on the higher loss coefficient rather than the solid type valve disk

Numerical study of hot-leg ECC injection into the upper plenum of a pressurized water reactor

International Nuclear Information System (INIS)

Daly, B.J.; Torrey, M.D.; Rivard, W.C.

1981-01-01

In certain pressurized water reactor (PWR) designs, emergency core coolant (ECC) is injected through the hot legs into the upper plenum. The condensation of steam on this subcooled liquid stream reduces the pressure in the hot legs and upper plenum and thereby affects flow conditions throughout the reactor. In the present study, we examine countercurrent steam-water flow in the hot leg to determine the deceleration of the ECC flow that results from an adverse pressure gradient and from momentum exchange from the steam by interfacial drag and condensation. For the parameters examined in the study, water flow reversal is observed for a pressure drop of 22 to 32 mBar over the 1.5 m hot leg. We have also performed a three-dimensional study of subcooled water injection into air and steam environments of the upper plenum. The ECC water is deflected by an array of cylindrical guide tubes in its passage through the upper plenum. Comparisons of the air-water results with data obtained in a full scale experiment shows reasonable agreement, but indicates that there may be too much resistance to horizontal flow about the columns because of the use of a stair-step representation of the cylindrical guide tube cross section. Calculations of flow past single columns of stair-step, square and circular cross section do indicate excessive water deeentrainment by the noncircular column. This has prompted the use of an arbitrary mesh computational procedure to more accuratey represent the circular cross-section guide tubes. 15 figures

Performance-based ECCS cladding acceptance criteria: A new simulation approach

International Nuclear Information System (INIS)

Zoino, A.; Alfonsi, A.; Rabiti, C.; Szilard, R.H.; Giannetti, F.; Caruso, G.

2017-01-01

Highlights: • A new methodology to demonstrate compliance with the new ECCS acceptance criteria is described. • A wide spectrum of fuel rod initial burnup states can be analysed in the design phase. • The coupled suite PHISICS/RELAP5-3D has been used in the analyses. • A demo simulation of the equilibrium cycle, load-following and a LOCA analysis has been performed. - Abstract: The U.S. Nuclear Regulatory Commission is currently proposing rulemaking to revise the Loss Of Coolant Accident (LOCA) and therefore the Emergency Core Cooling System (ECCS) acceptance criteria, to include the effects of higher burnup on cladding performance as well as to address other technical issues. As motivated by the new rule, the need to use advanced cladding designs may be a result. A loss of operational margin may result due to the more restrictive cladding embrittlement criteria. Initial and future compliance with the rule may significantly increase vendor workload and licensee cost, as a spectrum of fuel rod initial burnup states may need to be analyzed to demonstrate compliance. Consequently, there will be an increased focus on licensee decision making related to LOCA analysis to minimize cost and impact, and to manage margin. The study here presented has been part of a big project used to investigate technical issues and approaches for future industrial applications within the Risk-Informed Safety Margin Characterization (RISMC) Pathway. Specifically, the primary aim of this study is to lay out a roadmap to demonstrate the application of the new methodology. The present analysis shows a simplified version of the methodology of an industrial application on the Core Design and the Multi-Cycle Analysis.

Experiences with a high-blockage model tested in the NASA Ames 12-foot pressure wind tunnel

Science.gov (United States)

Coder, D. W.

1984-01-01

Representation of the flow around full-scale ships was sought in the subsonic wind tunnels in order to a Hain Reynolds numbers as high as possible. As part of the quest to attain the largest possible Reynolds number, large models with high blockage are used which result in significant wall interference effects. Some experiences with such a high blockage model tested in the NASA Ames 12-foot pressure wind tunnel are summarized. The main results of the experiment relating to wind tunnel wall interference effects are also presented.

Validation of attenuation, beam blockage, and calibration estimation methods using two dual polarization X band weather radars

Science.gov (United States)

Diederich, M.; Ryzhkov, A.; Simmer, C.; Mühlbauer, K.

2011-12-01

The amplitude a of radar wave reflected by meteorological targets can be misjudged due to several factors. At X band wavelength, attenuation of the radar beam by hydro meteors reduces the signal strength enough to be a significant source of error for quantitative precipitation estimation. Depending on the surrounding orography, the radar beam may be partially blocked when scanning at low elevation angles, and the knowledge of the exact amount of signal loss through beam blockage becomes necessary. The phase shift between the radar signals at horizontal and vertical polarizations is affected by the hydrometeors that the beam travels through, but remains unaffected by variations in signal strength. This has allowed for several ways of compensating for the attenuation of the signal, and for consistency checks between these variables. In this study, we make use of several weather radars and gauge network measuring in the same area to examine the effectiveness of several methods of attenuation and beam blockage corrections. The methods include consistency checks of radar reflectivity and specific differential phase, calculation of beam blockage using a topography map, estimating attenuation using differential propagation phase, and the ZPHI method proposed by Testud et al. in 2000. Results show the high effectiveness of differential phase in estimating attenuation, and potential of the ZPHI method to compensate attenuation, beam blockage, and calibration errors.

Risk-based assessment of the allowable outage times for the unit 1 leningrad nuclear power plant ECCS components

International Nuclear Information System (INIS)

Koukhar, Sergey; Vinnikov, Bronislav

2009-01-01

Present paper describes a method for risk - informed assessment of the Allowable Outage Times (AOTs). The AOT is the time, when components of a safety system allowed to be out of service during power operation or during shutdown operation off a plant. If the components are not restored during the time, the plant in operation must be shut down or the plant in a given shutdown mode has to go to safer shutdown mode. Application of the method is also provided for the equipment of the Unit 1 Leningrad NPP ECCS components. For solution of the problem it is necessary to carry out two series of computations using a Living PSA model, level 1. In the first series of the computations the core damage frequency (CDFb) for the base configuration of the plant is determined (there is no equipment out of service). Here the symbol 'b' means the base configuration of a plant. In the second series of the computations the core damage frequency (CDFi) for the configuration of the plant with the component (which is out of service) is calculated. That is here CDFi is determined for the failure probability of the component equal to 1.0 (component 'i' is unavailable). Then it is necessary to determine so called Risk Increase Factor (RIF) using the following ratio: RIFi = CDFi / CDFb. At last the AOT is calculated with the help of the ratio: AOTi = Tppr / RIFi, where Tppr is a period of time between two Planned Preventive Repairs (PPRs). 1. Using the risk based approach the AOTs were calculated for a set of the components of the Unit 1 Leningrad NPP ECCS components. 2. The main conclusion from the analysis is that the current deterministic AOTs for the ECCS components are conservative and should be extended. 3. The risk based extension of the AOTs for the ECCS components can prevent the Unit 1 Leningrad NPP to enter into the operating modes with increased risk. (author)

Audit of ECCS Availability for CANDU Reactors with an extended O/H interval

Energy Technology Data Exchange (ETDEWEB)

Choi, Jong Soo [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2011-10-15

KINS conducts regulatory periodic inspections of the safety and performance of each nuclear installation during the planned outage every 20 months, pursuant to the Atomic Energy Act. For CANDU reactors, planned outage or overhaul (O/H) have been performed every 15 months. KHNP has been making efforts to extend the O/H intervals of CANDU reactors into 20 months since 2001. Low ECCS availability is one of the regulatory pending issues in the related licensing

Air-water flooding in multirod channels: effects of spacer grids and blockages

International Nuclear Information System (INIS)

Cha, Jong Hee; Jun, Hyung Gil

1993-01-01

This paper presents the experimental results on flooding of countercurrent flow in vertical multirod channels, which consists of falling water film and upward air flow. In particular, the effects of spacer grids, with and without mixing vane, and of blockage in the multirod bundle on the behaviour of flooding were investigated. The 5 x 5 zircaloy tube bundle was used for the test section. The comparison of previous analytical models and empirical correlations with present data on flooding showed that the existing models and correlations predict much higher flooding curves. The spacer grid causes the lower flooding air flow rate to compare with the bare rod bundle. However, the mixing spacer grids need a higher flooding air flow rate for a constant liquid flow rate than the spacer grids without mixing vanes. The bundle containing blockages has the highest flooding air flow rate among the bundles with spacer grids and blokages. Empirical flooding correlations for the three types of test section have been made. (Author)

Modified ECC ozone sonde for long-duration flights aboard isopicnic drifting balloons

Science.gov (United States)

Gheusi, Francois; Durand, Pierre; Verdier, Nicolas; Dulac, François; Attié, Jean-Luc; Commun, Philippe; Barret, Brice; Basdevant, Claude; Clénet, Antoine; Fontaine, Alain; Jambert, Corinne; Meyerfeld, Yves; Roblou, Laurent; Tocquer, Flore

2015-04-01

Since few years, the French space agency CNES has developed boundary-layer pressurized balloons (BLPB) with the capability to transport scientific payloads at isopicnic level over very long distances and durations (up to several weeks in absence of navigation limits). However, the autonomy of conventional electrochemical concentration cell (ECC) ozone sondes, that are widely used for tropospheric and stratospheric soundings, is limited to few hours due to power consumption and electrolyte evaporation (owing to air bubbling in the cathode solution). In collaboration with the French research community, CNES has developed a new ozone payload suited for long duration flights aboard BLPB. The mechanical elements (Teflon pump and motor) and the electrochemical cell of conventional ECC sondes have been kept but the electronic implementation is entirely new. The main feature is the possibility of programming periodic measurement sequences -- with possible remote control during the flight. To increase the ozone sonde autonomy, a strategy has been adopted of short measurement sequences (typically 2-3 min) regularly spaced in time (e.g. every 15 min, which is usually sufficient for air quality studies). The rest of the time, the sonde is at rest (pump motor off). The response time of an ECC sonde to an ozone concentration step is below one minute. Consequently, the measurement sequence is typically composed of a one-minute spin-up period after the pump has been turned on, followed by a one- to two-minute acquisition period. All time intervals can be adjusted before and during the flight. Results of a preliminary ground-based test in spring 2012 are first presented. The sonde provided correct ozone concentrations against a reference UV analyzer every 15 minutes during 4 days. Then we illustrate results from 16 BLBP flights launched in the low troposphere over the Mediterranean during summer field campaings in 2012 and 2013 (TRAQA and ChArMEx programmes). BLPB drifting

Simulation of strain-hardening in ECC uniaxial test specimen by use of a damage mechanics formulation

DEFF Research Database (Denmark)

Dick-Nielsen, Lars; Stang, Henrik; Poulsen, Peter Noe

2006-01-01

scale it is shown that the cohesive law for a unidirectional fiber reinforced cementitious composite can be found through superposition of the cohesive law for mortar and the fiber bridging curve. On the meso scale I it is shown that the maximum crack opening observed during crack propagation in ECC...

EDF steam generators fleet: In-operation monitoring of TSP blockage and tube fouling

Energy Technology Data Exchange (ETDEWEB)

Bertrand, P.; Gay, N.; Crinon, R. [Electricite De France (France)

2012-07-01

EDF operates 58 Pressurized Water Reactors in France. In the mid 2000‟s some of them have been affected by Steam Generators (SG) Tube Support Plates (TSP) blockage and U-tubes external surface fouling with iron oxides deposits due to corrosion of secondary-side components. These issues have been tackled by a global maintenance strategy of chemical cleanings and a method for in-operation monitoring of fouling and TSP blockage has been developed and is implemented since mid 2009. This monitoring is aimed at giving information for SG maintenance planning as regards non destructive examinations and chemical cleaning. This paper will first remind of the physical reasons of fouling and TSP blockage and identify the resulting stakes regarding safety and availability along with the action levers available to control both phenomena. Then details will be given on how in-operation monitoring of fouling and TSP blockage is carried out, using measurements of Wide Range water Level (WRL) and SG steam pressure during thermally stabilized periods. Information will also be given on how those data are analyzed and shared as well at a local as at a corporate level to participate in the planning of SG inspection and maintenance operations. Finally, possible refinements will be discussed, notably regarding the issue of WRL measurements reliability and the possibility to use the analysis of SG dynamic behavior during power transients to assess the TSP blockage ratio. In terms of „issues requiring discussion‟, the following are operational issues currently being investigated by EDF: 1. SG pressure can have quite large variations during one operating cycle (notably after a plant trip) and from one cycle to the other and generally pressure tends to decrease on a long-term basis. How can such variations be explained? What are the solutions to moderate/stop the pressure loss? 2. On some of the SG-models operated by EDF, hard curative Chemical Cleaning of the U-tubes didn't bring

Wound-induced and bacteria-induced xylem blockage in roses, Astilbe and Viburnum

NARCIS (Netherlands)

Loubaud, M.; Doorn, van W.G.

2004-01-01

We previously concluded that the xylem blockage that prevents water uptake into several cut flowers is mainly due to the presence of bacteria, whilst in chrysanthemum and Bouvardia we observed a xylem occlusion that was mainly due to a wound-reaction of the plant. We have further tested which of

Shutdown cooling temperature perturbation test for analysis of potential flow blockages

International Nuclear Information System (INIS)

Handbury, J.; Newman, C.; Shynot, T.

1996-01-01

This paper details the methods and results of the 'shutdown cooling test' in October 1995. This novel test was conducted at PLGS while the reactor was shutdown and shutdown cooling (SDC) waster was recirculating to find potential channel blockages resulting from the introduction of wood debris. This test discovered most of the channels that contained major wood and metal debris. (author)

Safety evaluation report on Westinghouse Electric Company ECCS evaluation model for plants equipped with upper head injection

International Nuclear Information System (INIS)

Lauben, G.N.; Wagner, N.H.; Israel, S.L.; McPherson, G.D.; Hodges, M.W.

1978-04-01

For plants which include an ice condenser containment concept, Westinghouse has planned an additional safety system known as the upper head injection (UHI) system to augment the emergency core cooling system. This system is comprised of additional accumulator tanks and piping arranged to supply cooling water to the top of the core during the blowdown period following a postulated large-break loss-of-coolant accident (LOCA). The objective of UHI is to add to the core cooling provided by the conventional emergency core cooling system (ECCS) and so permit operation at linear heat rates comparable to those permitted in plants utilizing the dry containment concept. In this way, plants which include the UHI system would have greater operating flexibility while still meeting the acceptance criteria as defined in paragraph 50.46 of 10 CFR Part 50. This review is concerned with those changes to the Westinghouse ECCS evaluation model that have been proposed for the UHI-LOCA model

Observations of the behaviour of gas in the wake behind a corner blockage in fast breeder reactor subassembly geometry

International Nuclear Information System (INIS)

Fukuzawa, Y.

1979-07-01

Observations were made of gas behaviour in the wake behind a 21% corner blockage in the subassembly geometry of a liquid metal fast breeder reactor. The test section used represented one half of the reactor fuel subassembly, divided along the vertical plane of symmetry through the blockage. A glass wall occupied the position of this plane. Water was allowed to flow between glass rods simulating fuel pins, the velocity being changed from 1.2 to 4.5 m/s. Argon was injected into the wake or into the flow upstream of the blockage, the injection rate being changed from 1 to 230 Ncm 3 /s (standard temperature and pressure). From the present experiment, the following is evident: The gas is accumulated in the wake behind the blockage, forming a gas cavity. The flow patterns of the two-phase mixture in the wake are classified into three types, depending on the liquid velocity. In the lower velocity range, a gas cavity cannot be present at rest, rising up through the wake as a single bubble due to buoyancy. In the higher velocity range, the gas cavity is broken up by the liquid flow forces, only small gas bubbles circulating in the wake. In the velocity range in between, the gas cavity is present in the wake. The cavity size depends on the gas injection rate and on the liquid velocity. From the results, the possibility of fuel failure caused by fission gas release at a blockage in the fast breeder reactor can be considered to depend on the operating conditions of the reactor, specially on the coolant velocity. (orig.) [de

Steady-state thermal hydraulic analysis and flow channel blockage accident analysis of JRR-3 silicide core

International Nuclear Information System (INIS)

Kaminaga, Masanori

1997-03-01

JRR-3 is a light water moderated and cooled, beryllium and heavy water reflected pool type research reactor using low enriched uranium (LEU) plate-type fuels. Its thermal power is 20 MW. The core conversion program from uranium-aluminum (UAl x -Al) dispersion type fuel (aluminide fuel) to uranium-silicon-aluminum (U 3 Si 2 -Al) dispersion type fuel (silicide fuel) is currently conducted at the JRR-3. This report describes about the steady-state thermal hydraulic analysis results and the flow channel blockage accident analysis result. In JRR-3, there are two operation mode. One is high power operation mode up to 20 MW, under forced convection cooling using the primary and the secondary cooling systems. The other is low power operation mode up to 200 kW, under natural circulation cooling between the reactor core and the reactor pool without the primary and the secondary cooling systems. For the analysis of the flow channel blockage accident, COOLOD code was used. On the other hand, steady-state thermal hydraulic analysis for both of the high power operation mode under forced convection cooling and low power operation under natural convection cooling, COOLOD-N2 code was used. From steady-state thermal hydraulic analysis results of both forced and natural convection cooling, fuel temperature, minimum DNBR etc. meet the design criteria and JRR-3 LEU silicide core has enough safety margin under normal operation conditions. Furthermore, flow channel blockage accident analysis results show that one channel flow blockage accident meet the safety criteria for accident conditions which have been established for JRR-3 LEU silicide core. (author)

How to prevent ripening blockage in 1-MCP-treated 'Conference' pears.

Science.gov (United States)

Chiriboga, Maria-Angeles; Schotsmans, Wendy C; Larrigaudière, Christian; Dupille, Eve; Recasens, Inmaculada

2011-08-15

Some European pear varieties treated with 1-methylcyclopropene (1-MCP) often remain 'evergreen', meaning that their ripening process is blocked and does not resume after removal from cold storage. In this work this was confirmed also to be the case in 'Conference' pears. To reverse the blockage of ripening 1-MCP treatments combined with external exogenous ethylene were tested. 1-MCP treatment of 'Conference' pears is very effective in delaying ripening and, more specifically, softening. The same 1-MCP concentration in different experimental years caused a different response. The higher dose of 1-MCP (600 nL L⁻¹) always resulted in irreversible blockage of ripening, whereas the behaviour of fruit receiving a lower dose (300 nL L⁻¹) depended on the year, and this did not depend on maturity at harvest or on storage conditions. Simultaneous exposure to 1-MCP and exogenous ethylene significantly affected fruit ripening, allowing significant softening to occur but at a lower rate compared with control fruit. The application of exogenous ethylene and 1-MCP simultaneously after harvest permitted restoration of the ripening process after storage in 'Conference' pears, extending the possibility of marketing and consumption. Copyright © 2011 Society of Chemical Industry.

Analysis and modeling of flow blockage-induced steam explosion events in the High-Flux Isotope Reactor

International Nuclear Information System (INIS)

Taleyarkhan, R.P.; Georgevich, V.; Lestor, C.W.; Gat, U.; Lepard, B.L.; Cook, D.H.; Freels, J.; Chang, S.J.; Luttrell, C.; Gwaltney, R.C.; Kirkpatrick, J.

1993-01-01

This paper provides a perspective overview of the analysis and modeling work done to evaluate the threat from steam explosion loads in the High-Flux Isotope Reactor during flow blockage events. The overall workscope included modeling and analysis of core melt initiation, melt propagation, bounding and best-estimate steam explosion energetics, vessel failure from fracture, bolts failure from exceedance of elastic limits, and finally, missile evolution and transport. Aluminum ignition was neglected. Evaluations indicated that a thermally driven steam explosion with more than 65 MJ of energy insertion in the core region over several miliseconds would be needed to cause a sufficiently energetic missile with a capacity to cause early confinement failure. This amounts to about 65% of the HFIR core mass melting and participating in a steam explosion. Conservative melt propagation analyses have indicated that at most only 24% of the HFIR core mass could melt during flow blockage events under full-power conditions. Therefore, it is judged that the HFIR vessel and top head structure will be able to withstand loads generated from thermally driven steam explosions initiated by any credible flow blockage event. A substantial margin to safety was demonstrated

Analytical evaluation of local fault in sodium cooled small fast reactor (4S). Preliminary evaluation of partial blockage in coolant channel

International Nuclear Information System (INIS)

Nishimura, Satoshi; Ueda, Nobuyuki

2007-01-01

Local faults are fuel failures that result from heat removal imbalance within a single subassembly especially in FBRs. Although the occurrence frequency of local faults is quite low, the licensing body required local faults evaluations in previous FBR plants to confirm the potential for the occurrence of severe fuel subassembly failure and its propagation. A conceptual design of 4S (Super-Safe, Small and Simple) is a sodium cooled fast reactor, which aims at an application to dispersed energy source and long core lifetime. It has a dense arrangement of fuel pins to achieve a long lifetime. Therefore, from the viewpoint of thermal hydraulics, the 4S reactor is considered to have more potential for coolant boiling and fuel pin failure caused by formation of local blockage, comparing these potential in the conventional FBRs. The objective of the present study is to evaluate the effect of local blockage on the coolant flow pattern and temperature rise in the 4S-type fuel subassembly under the normal operation condition. A series of three-dimensional thermal-hydraulic analysis in a single subassembly with local blockage was conducted by the commercialized CFD code 'PHOENICS'. Analytical results show that the peak coolant temperature behind the blockage rises with increasing the blockage area, however, the coolant boiling does not occur under the present analytical conditions. On the other hand, it is found that the liquid phase formation caused by eutectic reactions will occur between the metallic fuel and the cladding under the local blockage condition. However, the penetration rate of liquid phase at fuel-cladding interface is quit low. Therefore, it is expected that rapid fuel pin failure and its propagation to surrounding pins due to liquid phase formation will not occur. (author)

Method of injecting cooling water in emergency core cooling system (ECCS) of PWR type reactor

International Nuclear Information System (INIS)

Sobajima, Makoto; Adachi, Michihiro; Tasaka, Kanji; Suzuki, Mitsuhiro.

1979-01-01

Purpose: To provide a cooling water injection method in an ECCS, which can perform effective cooling of the reactor core. Method: In a method of injecting cooling water in an ECCS as a countermeasure against a rupture accident of a pwr type reactor, cooling water in the first pressure storage injection system is injected into the upper plenum of the reactor pressure vessel at a set pressure of from 50 to 90 atg. and a set temperature of from 80 to 200 0 C, cooling water in the second pressure storage injection system is injected into the lower plenum of the reactor pressure vessel at a pressure of from 25 to 60 atg. which is lower than the set pressure and a temperature less than 60 0 C, and further in combination with these procedures, cooling water of less than 60 0 C is injected into a high-temperature side piping, in the high-pressure injection system of upstroke of 100 atg. by means of a pump and the low-pressure injection system of upstroke of 20 atg. also by means of a pump, thereby cooling the reactor core. (Aizawa, K.)

Exxon Nuclear Company ECCS evaluation of a 2-loop Westinghouse PWR with dry containment using the ENC WREM-II ECCS model. Large break example problem

International Nuclear Information System (INIS)

Krajicek, J.E.

1977-01-01

This document is presented as a demonstration of the ENC WREM-II ECCS model calculational procedure applied to a Westinghouse 2-loop PWR with a dry containment (R. E. Ginna plant, for example). The hypothesized Loss-of-Coolant Accident (LOCA) investigated was a split break with an area equal to twice the pipe cross-sectional area. The break was assumed to occur in one pump discharge pipe (DECLS break). The analyses involved calculations using the ENC WREM-II model. The following codes were used: RELAP4-EM/ENC26A for blowdown and hot channel analyses, RELAP4-EM FLOOD/ENC26A for core reflood analysis, CONTEMPT LT/22 modified for containment backpressure analysis, and TOODEE2/APR77 for heatup analysis

Incorporating Indigenous Knowledge and Practice into ECCE: A Comparison of Programs in The Gambia, Senegal and Mali

Science.gov (United States)

Soudee, Alicia Ranck

2009-01-01

Early Childhood Development (ECD) has emerged as a theme in international and African dialogue on education in recent years. UNESCO's Division of Basic Education Early Childhood promotes an integrated approach to Early Childhood Care and Education (ECCE) policy development and review. The study examines how this is implemented in three West…

Analysis of Post-LOCA Core Inlet Blockage to Evaluate In-vessel Downstream Effect in APR1400

International Nuclear Information System (INIS)

Bang, Young Seok

2015-01-01

The method was developed to have a conservatism to cover the uncertainty of analysis and the acceptance is judged by the representative bounding estimation. However, the important safety parameters such as the available driving head need to be confirmed by the plant specific calculation. Also an interaction between the debris induced head loss and the core flow rate needs to be explained because the head loss induced by debris in actual condition may reduce the core inflow rate faster. To confirm the safety parameters, in this study, thermal-hydraulic response considering the core inlet blockage (CIB) by debris during LTCC process following a double-ended guillotine break of cold leg (CLB), one of hot leg (HLB) and one of intermediate leg (ILB) of the APR1400 were calculated, respectively. MARS-KS 1.3 code has been used. The CIB has been modeled by the closure of valves to the core in exponential manner with time to observe the behavior near the complete blockage. To understand the effect of core inlet blockage (CIB) during a long term core cooling (LTCC) phase following a loss-of-coolant accident (LOCA) in the light of in-vessel downstream effect (IDE) of Generic Safety Issue (GSI) 191, double-ended guillotine break of hot leg (HLB), one of cold leg (CLB) and one of intermediate leg (ILB) were calculated, respectively. And the important safety parameters such as the available driving head and the head loss due to debris were calculated using MARS-KS code and discussed in comparison with the WCAP method. As a result, a little delayed heatup behavior of the fuel cladding was found for all the cases, which due to the redistribution of flow within the core after blockage

Analysis of Post-LOCA Core Inlet Blockage to Evaluate In-vessel Downstream Effect in APR1400

Energy Technology Data Exchange (ETDEWEB)

Bang, Young Seok [Korea Institute of Nuclear Safety, Daejeon (Korea, Republic of)

2015-10-15

The method was developed to have a conservatism to cover the uncertainty of analysis and the acceptance is judged by the representative bounding estimation. However, the important safety parameters such as the available driving head need to be confirmed by the plant specific calculation. Also an interaction between the debris induced head loss and the core flow rate needs to be explained because the head loss induced by debris in actual condition may reduce the core inflow rate faster. To confirm the safety parameters, in this study, thermal-hydraulic response considering the core inlet blockage (CIB) by debris during LTCC process following a double-ended guillotine break of cold leg (CLB), one of hot leg (HLB) and one of intermediate leg (ILB) of the APR1400 were calculated, respectively. MARS-KS 1.3 code has been used. The CIB has been modeled by the closure of valves to the core in exponential manner with time to observe the behavior near the complete blockage. To understand the effect of core inlet blockage (CIB) during a long term core cooling (LTCC) phase following a loss-of-coolant accident (LOCA) in the light of in-vessel downstream effect (IDE) of Generic Safety Issue (GSI) 191, double-ended guillotine break of hot leg (HLB), one of cold leg (CLB) and one of intermediate leg (ILB) were calculated, respectively. And the important safety parameters such as the available driving head and the head loss due to debris were calculated using MARS-KS code and discussed in comparison with the WCAP method. As a result, a little delayed heatup behavior of the fuel cladding was found for all the cases, which due to the redistribution of flow within the core after blockage.

Experimental investigation of pressure and blockage effects on combustion limits in H2-air-steam mixtures

International Nuclear Information System (INIS)

Sherman, M.P.; Berman, M.; Beyer, R.F.

1993-06-01

Experiments with hydrogen-air-steam mixtures, such as those found within a containment system following a reactor accident, were conducted in the Heated Detonation Tube (43 cm diameter and 12 m long) to determine the region of benign combustion; i.e., the region between the flammability limits and the deflagration-to-detonation transition limits. Obstacles were used to accelerate the flame; these include 30% blockage ratio annular rings, and alternate rings and disks of 60% blockage ratio. The initial conditions were 110 degree C and one or three atmospheres pressure. A benign burning region exists for rich mixtures, but is generally smaller than for lean mixtures. Effects of the different obstacles and of the different pressures are discussed

Results of postirradiation examination of the in-pile blockage experiments MOL-7C/4 and MOL-7C/5

International Nuclear Information System (INIS)

Weimar, P.; Schleisiek, K.

1991-01-01

The Mol-7C in-pile local blockage experiments are performed in the BR-2 reactor at Mol, Belgium as a joint project of Kernforchungszentrum Karlsruhe (KfK) and Studiecentrum voor Kernenergie/Centre d'Etude de l'Energie Nuclearire-Mol. The main objective is to investigate the consequences of local cooling disturbances in liquid-metal-cooled reactor (LMR) fuel subassemblies. In the tests Mol-7C/4 and MOL-7C/5, fuel pins from KNK II are used with a burnup of 5 and 1.7%, respectively. An active central porous blockage is used to simulate the cooling disturbance. During irradiation, the blockage causes significant local damage, including melting of cladding and fuel. Extensive postirradiation examinations (PIE) are performed to investigate the extent of damage. In this paper a description and interpretation of results of the destructive PIE performed at the Hot Cells Laboratory at KfK is given, along with some conclusions related to LMR safety

Experiment data report for Semiscale Mod-1 Test S-05-2 (alternate ECC injection test)

International Nuclear Information System (INIS)

Feldman, E.M.; Collins, B.L.; Sackett, K.E.

1977-02-01

Recorded test data are presented for Test S-05-2 of the Semiscale Mod-1 alternate emergency core coolant (ECC) injection test series. This test is one of several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-2 was conducted from an initial cold leg fluid temperature of 545 0 F and an initial pressure of 2263 psia. A simulated double-ended offset shear cold leg break was used to investigate core and system response to a depressurization and reflood transient with ECC injection at the intact loop pump suction and broken loop cold leg. A reduced lower plenum volume was used for this test to more accurately represent the lower plenum of a PWR, based on system volume scaling. System flow was set to achieve a core fluid temperature differential of 65 0 F at a core power level of 1.44 MW. The flow resistance of the intact loop was based on core area scaling. An electrically heated core with a slightly peaked radial power profile was used in the pressure vessel to simulate the predicted surface heat flux of nuclear fuel rods during a loss-of-coolant accident

Assessment of human effective absorbed dose of 67 Ga-ECC based on biodistribution rat data.

Science.gov (United States)

Shanehsazzadeh, Saeed; Yousefnia, Hassan; Lahooti, Afsaneh; Zolghadri, Samaneh; Jalilian, Amir Reza; Afarideh, Hossien

2015-02-01

In a diagnostic context, determination of absorbed dose is required before the introduction of a new radiopharmaceutical to the market to obtain marketing authorization from the relevant agencies. In this work, the absorbed dose of [67 Ga]-ethylenecysteamine cysteine [(67 Ga)ECC] to human organs was determined by using distribution data for rats. For biodistribution data, the animals were sacrificed by CO2 asphyxiation at selected times after injection (0.5, 2 and 48 h, n = 3 for each time interval), then the tissue (blood, heart, lung, brain, intestine, feces, skin, stomach, kidneys, liver, muscle and bone) were removed. The absorbed dose was determined by Medical Internal Radiation Dose (MIRD) method after calculating cumulated activities in each organ. Our prediction shows that a 185-MBq injection of (67)Ga-ECC into the humans might result in an estimated absorbed dose of 0.029 mGy in the whole body. The highest absorbed doses are observed in the spleen and liver with 33.766 and 16.847 mGy, respectively. The results show that this radiopharmaceutical can be a good SPECT tracer since it can be produced easily and also the absorbed dose in each organ is less than permitted absorbed dose.

Local blockage of EMMPRIN impedes pressure ulcers healing in a rat model.

Science.gov (United States)

Zhao, Xi-Lan; Luo, Xiao; Wang, Ze-Xin; Yang, Guo-Li; Liu, Ji-Zhong; Liu, Ya-Qiong; Li, Ming; Chen, Min; Xia, Yong-Mei; Liu, Jun-Jie; Qiu, Shu-Ping; Gong, Xiao-Qing

2015-01-01

Excessive extracellular matrix degradation caused by the hyperfunction of matrix metalloproteinases (MMPs) has been implicated in the failure of pressure ulcers healing. EMMPRIN, as a widely expressed protein, has emerged as an important regulator of MMP activity. We hypothesize that EMMPRIN affects the process of pressure ulcer healing by modulating MMP activity. In the rat pressure ulcer model, the expression of EMMPRIN in ulcers detected by Western blot was elevated compared with that observed in normal tissue. To investigate the role of EMMPRIN in regulating ulcer healing, specific antibodies against EMMPRIN were used via direct administration on the pressure ulcer. Local blockage of EMMPRIN resulted in a poor ulcer healing process compared with control ulcers, which was the opposite of our expectation. Furthermore, inhibiting EMMPRIN minimally impacted MMP activity. However, the collagen content in the pressure ulcer was reduced in the EMMPRIN treated group. Angiogenesis and the expression of angiogenic factors in pressure ulcers were also reduced by EMMPRIN local blockage. The results in the present study indicate a novel effect of EMMPRIN in the regulation of pressure ulcer healing by controlling the collagen contents and angiogenesis rather than MMPs activity.

Feeding practice among 6-36 months old in Tanzania and Uganda: reliability and relationship with early childhood caries, ECC.

Science.gov (United States)

Masumo, Ray; Bardsen, Asgeir; Mashoto, Kijakazi; Åstrøm, Anne Nordrehaug

2013-09-01

To assess the reproducibility of caregivers' responses to dietary recall from birth and 24-h dietary recall with respect to infants' intake of sugared snacks and to assess whether those assessment methods provide comparable results for groups of infants. Re-test reliability and clinical covariates of time to first exposure of sugared snacks and time to termination of breastfeeding were also examined. It was hypothesized that time to first exposure/termination would vary according to socio-demographic profile and ECC. Interviews and clinical oral examinations were carried out in Kampala and Manyara, including 1221 and 816 child-caregiver pairs. Reproducibility was assessed using Cohen's kappa and Intra Class Correlation Coefficient, ICC. Adjusted Cox regression was used to model time to first exposure of sugared snacks and time to termination of breastfeeding. Cohen's kappa for intake of sugar items ranged from 0.40-1.0, with no differences observed between average intakes at test-re-test. Mean sugar score based on 24-h recall increased significantly by increasing quartiles of the sugar score based on recall from birth. Cox regression revealed that the odds ratio, OR, for early exposure to various sugared snacks and the ORs for early termination of breastfeeding were significantly smaller in infants with than without ECC. Fair-to-good reproducibility was established. Infant's sugar consumption emerge as early as 6 months of age. Survival of any breastfeeding and non-exposure to sugared snacks was most prolonged among infants with ECC. This has implications for interventions needed to improve feeding habits of infants and toddlers.

Nietzsche como destino da filosofia e da humanidade? interpretação contextual do § 1 do capítulo "por que sou um destino", de ecce homo

Directory of Open Access Journals (Sweden)

Werner Stegmaier

2010-01-01

Full Text Available The following translation is a reduced and revised version of the paper Schicksal Nietzsche? Zu Nietzsches Selbsteinschätzung als Schicksal der Philosophie und der Menschheit (Ecce Homo, Warum ich ein Schicksal bin §1" - originally published in Nietzsche-Studien 37 (2008 - which was specially prepared to be presented in lecture organized by the Grupo de Pesquisa Spinoza & Nietzsche (Spinoza & Nietzsche research group - SpiN, in the Universidade Federal do Rio de Janeiro (Rio de Janeiro's Federal University, on September 14, 2009. In the text, the autor employs his own philological-hermeneutical methodology, which is called contextual interpretation, in the purpose to clarify the concepts of the first aphorism from "Why I am a destiny", from Ecce Homo, in its own context, in the context of Ecce Homo and in the context of the entire work from Nietzsche.

A Novel Method for Borehole Blockage Removal and Experimental Study on a Hydraulic Self-Propelled Nozzle in Underground Coal Mines

Directory of Open Access Journals (Sweden)

Zhaolong Ge

2016-08-01

Full Text Available When coal bed methane (CBM drainage boreholes cross fractured, soft, or water-swelling strata, they collapse and block frequently. Borehole blockages result in a rapid decrease in CBM extraction ability, which leads to a reduction in CBM output and threatens coal mine safety production. To solve these problems, a novel method that uses a self-propelled water-jet nozzle to dredge blocked boreholes in coal seams has been proposed on the basis of the existing technology. Based on a theoretical analysis of the reason for borehole caving and the theory of blockage removal, we optimized the nozzle inlet pressure and selected an appropriate high-pressure resin pipe. A field experiment on the blockage removal of blocked CBM drainage boreholes using the proposed method was run in the Fengchun coal mine, Qijiang, Chongqing, southwest China. In this field trial, the time spent to unblock a borehole varied between 18.52 and 34.98 min, which is much shorter than using a drilling rig. After blockage removal, the average pure volume of the methane drainage of a single borehole was increased from 0.03 L/min to ~1.91–7.30 L/min, and the methane drainage concentration of a single borehole increased from 5% to ~44%–85%. The extraction effect increased significantly.

French studies on local blockages in LMFBR fuel subassemblies

International Nuclear Information System (INIS)

Girard, C.; Jolas, P.; Seiler, J.M.

1979-08-01

This paper reviews experimental and theoretical studies done in FRANCE on the problem of partial subassembly blockages. The priorities are defined and the development of the French program in the European context is presented. Results of the out of pile experiments performed at CEA and EDF in single and two phases flow are given. A description of the main codes used to interpret these experiments is then shortly reviewed. It is found that the thermal behavior in single phase may be calculated with good precision, and that a simple semi-empirical formula can predict with good accuracy the number of channels blocked that lead to sodium boiling

Influence of blockage effect on measurement by vane anemometers

Directory of Open Access Journals (Sweden)

Sluse Jan

2017-01-01

Full Text Available The article deals with influence of blockage effect caused by vane anemometer in the wind tunnel by measurement via this anemometer. The influences will be represented by correction coefficient. The first part of this article is focused on the design of the impeller of vane anemometers. The impellers are printed on 3D printer with variable parameters. The anemometer is fixed in an open section of the wind tunnel with closed loop and the velocity profile is measured by Laser Doppler velocimetry (LDV in front and behind it for all impellers. The experimental data are compared with the numerical simulation in OpenFOAM. The results are correction coefficients.

Local flow blockage analysis with checkerboard configuration in a wire wrapped fuel subassembly using the ASFRE code

International Nuclear Information System (INIS)

Nishimura, Masahiro; Fukano, Yoshitaka

2014-01-01

Local fault (LF) has been historically considered as one of the possible causes of severe accidents in sodium-cooled fast reactors because fuel pins are generally densely arranged in the fuel subassemblies (FSAs) in this type of reactors. Local flow blockage (LB) has been one of the dominant initiators of LFs. Therefore evaluations were performed on LBs in the past safety licensing assuming a planar and impermeable blockage of 66% of the total flow area at an FSA for the Japanese prototype fast breeder reactor. A conservative evaluation revealed that fuel pin damage propagation would be limited within a restricted area of the reactor core, even assuming such a hypothetical initiating event. In the newly formulated regulatory requirements, however, after the accident at the Fukushima Dai-ichi nuclear power plant, best estimate (BE) safety analyses on the basis of state-of-the-art knowledge are being required for beyond design basis accidents. A deterministic and BE evaluation therefore based on the most-recent knowledge was newly performed in this study for revalidation of the above-mentioned historical background using the ASFRE code, whereas the LF accidents would not be identified as a representative accident sequence from a viewpoint of both its frequencies and consequences. Nominal power and flow rate without safety margins were assumed for the analyses in order to make the accidental conditions to be realistic. A most likely and realistic blockage configuration was newly proposed and employed based on the existing experimental data in accordance with the BE concept mentioned above. The aforementioned blockage configuration was excessively conservative on a state-of-the-art knowledge basis. The most-recent experimental studies clarified that LBs due to foreign substances would be formed by accumulating the steel fragments of certain sizes trapped along the wrapping wires. This leads to an LB in a checkerboard configuration for an FSA of wire spacer type, which

Studies on the effects of blockage upon LWR emergency core cooling systems

International Nuclear Information System (INIS)

Fairbairn, S.A.; Piggott, B.D.G.

1985-01-01

Ballooning of the zircaloy cladding of PWR fuel pins could occur during a conservatively calculated large break LOCA. This report is Part 3 of three reports which describe the experimental data obtained in a 44 rod bundle with and without localised coplanar blockages under conditions relevant to the reflood phase of a LOCA. The various thermohydraulic effects are investigated separately, as far as possible, in a unique series of tests of increasing complexity proceeding from single to two phase conditions as follows: isothermal air flow tests, used to infer single phase mass flow distribution; steady state steam flow tests, used to quantify single phase heat transfer; steam and drop tests, in which a dispersed flow of well specified inlet conditions is created by injecting water drops into the subchannel centres between the rods with a co-current steam flow; and finally conventional reflood tests. This report makes an extensive presentation of data obtained from a bundle containing a centrally placed 4 x 4 array of balloon shapes. The balloon sleeves were hydraulically formed to give a wall thickness of 0.325 mm typical of reactor fuel pin balloons. They were 196 mm long with a maximum subchannel blockage of 61% over a 175 mm length. 6 refs., 15 tabl., 134 figs.

Modeling of the hERG K+ Channel Blockage Using Online Chemical Database and Modeling Environment (OCHEM).

Science.gov (United States)

Li, Xiao; Zhang, Yuan; Li, Huanhuan; Zhao, Yong

2017-12-01

Human ether-a-go-go related gene (hERG) K+ channel plays an important role in cardiac action potential. Blockage of hERG channel may result in long QT syndrome (LQTS), even cause sudden cardiac death. Many drugs have been withdrawn from the market because of the serious hERG-related cardiotoxicity. Therefore, it is quite essential to estimate the chemical blockage of hERG in the early stage of drug discovery. In this study, a diverse set of 3721 compounds with hERG inhibition data was assembled from literature. Then, we make full use of the Online Chemical Modeling Environment (OCHEM), which supplies rich machine learning methods and descriptor sets, to build a series of classification models for hERG blockage. We also generated two consensus models based on the top-performing individual models. The consensus models performed much better than the individual models both on 5-fold cross validation and external validation. Especially, consensus model II yielded the prediction accuracy of 89.5 % and MCC of 0.670 on external validation. This result indicated that the predictive power of consensus model II should be stronger than most of the previously reported models. The 17 top-performing individual models and the consensus models and the data sets used for model development are available at https://ochem.eu/article/103592. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Investigation of flow blockage in a fuel channel with the ASSERT subchannel code

International Nuclear Information System (INIS)

Harvel, G.D.; Dam, R.; Soulard, M.

1996-01-01

On behalf of New Brunswick Power, a study was undertaken to determine if safe operation of a CANDU-6 reactor can be maintained at low reactor powers with the presence of debris in the fuel channels. In particular, the concern was to address if a small blockage due to the presence of debris would cause a significant reduction in dryout powers, and hence, to determine the safe operation power level to maintain dryout margins. In this work the NUCIRC(1,2), ASSERT-IV(3), and ASSERT-PV(3) computer codes are used in conjunction with a pool boiling model to determine the safe operation power level which maintains dryout safety margins. NUCIRC is used to provide channel boundary conditions for the ASSERTcodes and to select a representative channel for analysis. This pool boiling model is provided as a limiting lower bound analysis. As expected, the ASSERT results predict higher CHF ratios than the pool boiling model. In general, the ASSERT results show that as the model comes closer to modelling a complete blockage it reduces toward, but does not reach the pool boiling model. (author)

Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis.

Science.gov (United States)

Mizutani, Nobuaki; Nabe, Takeshi; Shimazu, Masaji; Yoshino, Shin; Kohno, Shigekatsu

2012-03-01

Ganoderma lucidum (GL), an oriental medical mushroom, has been used in Asia for the prevention and treatment of a variety of diseases. However, the effect of GL on allergic rhinitis has not been well defined. The current study describes the inhibitory effect of GL on the biphasic nasal blockage and nasal hyperresponsiveness induced by repeated antigen challenge in a guinea pig model of allergic rhinitis. Intranasally sensitized guinea pigs were repeatedly challenged by inhalation of Japanese cedar pollen once every week. Ganoderma lucidum was orally administered once daily for 8 weeks from the time before the first challenge. The treatment with GL dose-dependently inhibited the early and late phase nasal blockage at the fifth to ninth antigen challenges. Furthermore, nasal hyperresponsiveness to intranasally applied leukotriene D₄ on 2 days after the eighth antigen challenge was also inhibited by the treatment with GL. However, Cry j 1-specific IgE antibody production was not affected by the treatment. In conclusion, we demonstrated that the pollen-induced biphasic nasal blockage and nasal hyperresponsiveness were suppressed by the daily treatment with GL in the guinea pig model of allergic rhinitis. These results suggest that GL may be a useful therapeutic drug for treating patients with allergic rhinitis. Copyright © 2011 John Wiley & Sons, Ltd.

Quick Look Report of the SMART ECC injection performance test I3

Energy Technology Data Exchange (ETDEWEB)

Cho, Seok; Ko, Yong Ju; Cho, Young Il; Kim, Jeong Tak; Choi, Nam Hyun; Park, Choon Kyong; Kwon, Tae Soon; Lee, Sung Jae [KAERI, Daejeon (Korea, Republic of)

2010-12-15

The objective of this report is to describe test results of the Test I3 simulating the 2 inch SBLOCA of the SMART using the SWAT test facility. The Test I3 was performed to produce experimental data for the validation of the TASS/SMR-S thermal hydraulic analysis code, and to investigate the related thermal hydraulic phenomena in the down-comer region during the 2 inch SBLOCA of the safety inject line. The particular phenomena for the observation are ECC bypass and multi-dimensional flow characteristics to verify the effectiveness and performance of the safety injection system. In this report, the corresponding steady state test conditions, including initial and boundary conditions along with major measuring parameters, and related experimental results were described

Strong transcription blockage mediated by R-loop formation within a G-rich homopurine-homopyrimidine sequence localized in the vicinity of the promoter.

Science.gov (United States)

Belotserkovskii, Boris P; Soo Shin, Jane Hae; Hanawalt, Philip C

2017-06-20

Guanine-rich (G-rich) homopurine-homopyrimidine nucleotide sequences can block transcription with an efficiency that depends upon their orientation, composition and length, as well as the presence of negative supercoiling or breaks in the non-template DNA strand. We report that a G-rich sequence in the non-template strand reduces the yield of T7 RNA polymerase transcription by more than an order of magnitude when positioned close (9 bp) to the promoter, in comparison to that for a distal (∼250 bp) location of the same sequence. This transcription blockage is much less pronounced for a C-rich sequence, and is not significant for an A-rich sequence. Remarkably, the blockage is not pronounced if transcription is performed in the presence of RNase H, which specifically digests the RNA strands within RNA-DNA hybrids. The blockage also becomes less pronounced upon reduced RNA polymerase concentration. Based upon these observations and those from control experiments, we conclude that the blockage is primarily due to the formation of stable RNA-DNA hybrids (R-loops), which inhibit successive rounds of transcription. Our results could be relevant to transcription dynamics in vivo (e.g. transcription 'bursting') and may also have practical implications for the design of expression vectors. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Effect of Local Nasal Immunotherapy on Nasal Blockage in Pollen-Induced Allergic Rhinitis of Guinea Pigs

Directory of Open Access Journals (Sweden)

Takeshi Nabe

2008-01-01

Conclusions: Local nasal immunotherapy may be clinically useful for allergic nasal blockage associated with nasal hyperresponsiveness. The mechanisms responsible for this effectiveness might not be related to IgE production. Additionally, the effectiveness for nasal tissue was dissociated from that seen for the ocular tissue.

Experimental and numerical investigation on heat transfer augmentation in a circular tube under forced convection with annular differential blockages/inserts

Science.gov (United States)

Waghole, D. R.

2018-01-01

Investigation on heat transfer by generating turbulence in the fluid stream inside the circular tube is an innovative area of research for researchers. Hence, many techniques are been investigated and adopted for enhancement of heat transfer rate to reduce the size and the cost of the heat exchanger/circular tube. In the present study the effect of differential solid ring inserts /turbulators on heat transfer, friction factor of heat exchanger/circular tube was evaluated through experimentally and numerically. The experiments were conducted in range of 3000 ≤Re≤ 6500 and annular blockages 0 ≤ɸ≤50 %. The heat transfer rate was higher for differential combination of inserts as compared to tube fitted with uniform inserts. The maximum heat transfer was obtained by the use of differential metal circular ring inserts/blockages. From this study, Nusselt number, friction factor and enhancement factor are found as 2.5-3.5 times, 12% - 50.5% and 155% - 195%, respectively with water. Finally new possible correlations for predicting heat transfer and friction factor in the flow of water through the circular tube with differential blockages/inserts are proposed.

The development of code for the analysis of the flow blockage of rod bundles of LMR

International Nuclear Information System (INIS)

Ha, Q. S.; Jeong, H. Y.; Jang, W. P.; Lee, Y. B.

2003-01-01

A partial flow blockage within a fuel assembly in liquid metal reactor may result in localized boiling or a failure of the fuel cladding. Thus, the precise analysis for the phenomenon is required for a safe design of LMR. To take account of the effects of the surfaces of rod and wire spacer on the fluid, the distributed resistance model was implemented into the MATRA-LMR code, which is important to the analysis for flow blockage. Also central differencing scheme for the velocities is used in the flow with the lRel less than 2 and for the enthalpies with the lPel less than 2. Diffusion terms are added to the equations of momentum and energy. The validation calculation was carried out against to the experiment of FFM series tests and the results using MATRA-LMR with the distributed resistance model and above hybrid scheme well agree with the experimental data

Analysis and modeling of flow-blockage-induced steam explosion events in the high-flux isotope reactor

International Nuclear Information System (INIS)

Taleyarkhan, R.P.; Georgevich, V.; Nestor, C.W.; Gat, U.; Lepard, B.L.; Cook, D.H.; Freels, J.; Chang, S.J.; Luttrell, C.; Gwaltney, R.C.

1994-01-01

This article provides a perspective overview of the analysis and modeling work done to evaluate the threat from steam explosion loads in the High-Flux Isotope Reactor (HFIR) during flow blockage events. The overall work scope included modeling and analysis of core-melt initiation, melt propagation, bounding and best-estimate steam explosion energetics, vessel failure from fracture, bolts failure from exceedance of elastic limits, and, finally, missile evolution and transport. Aluminum ignition was neglected. Evaluations indicated that a thermally driven steam explosion with more than 65 MJ of energy insertion in the core region over several milliseconds would be needed to cause a sufficiently energetic missile with a capacity to cause early confinement failure. This amounts to about 65% of the HFIR core mass melting and participating in a steam explosion. Conservative melt propagation analyses have indicated that at most only 24% of the HFIR core mass could melt during flow blockage events under full-power conditions. 19 refs., 11 figs

Study on safety analysis of VVER-1200/V491 in scenario of Loss of Coolant Accidents along with partly failure of ECCS using RELAP5 code

International Nuclear Information System (INIS)

Hoang Minh Giang; Ha Thi Anh Dao; Hoang Tan Hung; Bui Thi Hoa; Nguyen Thi Tu Oanh; Dinh Anh Tuan; Pham Tuan Nam

2017-01-01

The advanced VVER-1200/V491 reactor designed with passive safety systems to deal with design extension conditions is primarily selected as priority candidate for Ninh Thuan 1 nuclear power plant project. So that, in order to enhance competence of nuclear safety and toward participation on review Safety Analysis Report (SAR) of Ninh Thuan nuclear Power project the study on safety analysis of VVER-1200/V491 in scenario of Loss of Coolant Accidents along with partly failure of ECCS is implemented. As requirement of the study, the input deck file of VVER-1200/V491 for RELAP5 and analysis report for some special case of LOCAs along with partly failure of ECCS are issued. (author)

Assessment of compliance with regulatory requirements for a best estimate methodology for evaluation of ECCS

Energy Technology Data Exchange (ETDEWEB)

Lee, Un Chul; Jang, Jin Wook; Lim, Ho Gon; Jeong, Ik [Seoul National Univ., Seoul (Korea, Republic of); Sim, Suk Ku [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

2000-03-15

Best estimate methodology for evaluation of ECCS proposed by KEPCO(KREM) os using thermal-hydraulic best-estimate code and the topical report for the methodology is described that it meets the regulatory requirement of USNRC regulatory guide. In this research the assessment of compliance with regulatory guide. In this research the assessment of compliance with regulatory requirements for the methodology is performed. The state of licensing procedure of other countries and best-estimate evaluation methodologies of Europe is also investigated, The applicability of models and propriety of procedure of uncertainty analysis of KREM are appraised and compliance with USNRC regulatory guide is assessed.

Industry Application ECCS / LOCA Integrated Cladding/Emergency Core Cooling System Performance: Demonstration of LOTUS-Baseline Coupled Analysis of the South Texas Plant Model

Energy Technology Data Exchange (ETDEWEB)

Zhang, Hongbin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Szilard, Ronaldo [Idaho National Lab. (INL), Idaho Falls, ID (United States); Epiney, Aaron [Idaho National Lab. (INL), Idaho Falls, ID (United States); Parisi, Carlo [Idaho National Lab. (INL), Idaho Falls, ID (United States); Vaghetto, Rodolfo [Texas A & M Univ., College Station, TX (United States); Vanni, Alessandro [Texas A & M Univ., College Station, TX (United States); Neptune, Kaleb [Texas A & M Univ., College Station, TX (United States)

2017-06-01

Under the auspices of the DOE LWRS Program RISMC Industry Application ECCS/LOCA, INL has engaged staff from both South Texas Project (STP) and the Texas A&M University (TAMU) to produce a generic pressurized water reactor (PWR) model including reactor core, clad/fuel design and systems thermal hydraulics based on the South Texas Project (STP) nuclear power plant, a 4-Loop Westinghouse PWR. A RISMC toolkit, named LOCA Toolkit for the U.S. (LOTUS), has been developed for use in this generic PWR plant model to assess safety margins for the proposed NRC 10 CFR 50.46c rule, Emergency Core Cooling System (ECCS) performance during LOCA. This demonstration includes coupled analysis of core design, fuel design, thermalhydraulics and systems analysis, using advanced risk analysis tools and methods to investigate a wide range of results. Within this context, a multi-physics best estimate plus uncertainty (MPBEPU) methodology framework is proposed.

Two neural network based strategies for the detection of a total instantaneous blockage of a sodium-cooled fast reactor

International Nuclear Information System (INIS)

Martinez-Martinez, Sinuhe; Messai, Nadhir; Jeannot, Jean-Philippe; Nuzillard, Danielle

2015-01-01

The total instantaneous blockage (TIB) of an assembly in the core of a sodium-cooled fast reactor (SFR) is investigated. Such incident could appear as an abnormal rise in temperature on the assemblies neighbouring the blockage. Its detection relies on a dataset of temperature measurements of the assemblies making up the core of the French Phenix Nuclear Reactor. The data are provided by the French Commission of Atomic and Alternatives Energies (CEA). Here, two strategies are proposed depending on whether the sensor measurement of the suspected assembly is reliable or not. The proposed methodology implements a time-lagged feed-forward neural (TLFFN) Network in order to predict the one-step-ahead temperature of a given assembly. The incident is declared if the difference between the predicted process and the actual one exceeds a threshold. In these simulated conditions, the method is efficient to detect small gradients as expected in reality. - Highlights: • We study the total instantaneous blockage (TIB) of a sodium-cooled fast reactor. • The TIB symptom is simulated as an abrupt rise on temperature (0.1–1 °C/s). • The goal is to improve the early detection of the incident. • Two strategies laying on neural networks are proposed. • TIB is detected in 3 s for 1 °C/s and 18–21 s for 0.1 °C/s

Guideline on in-service testing (IST) of ECCS for nuclear power stations in Japan

International Nuclear Information System (INIS)

Yamashita, N.; Honjin, M.; Yamazaki, M.; Iwami, H.

2001-01-01

In Japan, METI (Ministry of Economy, Trade and Industry) periodic inspections are conducted every 13 months in accordance with the EUIL (Electric Utility Industry Law) for light water reactors. On the other hand, during operation, many kinds of function tests are conducted in accordance with Technical Specifications or utilities voluntary test procedures. However, these maintenance activities during outages are in other respects considered too costly and more than necessary because of its predetermined maintenance interval and its old-fashioned full scope maintenance menu. In these circumstances, the ASME O and M Codes and Standards, which are applied to nuclear power plants in the United States, came to be one of the issues to be considered among Japanese utilities. This is because the ASME O and M Codes and Standards, which are developed to verify the operational readiness of equipment or systems by condition based maintenance or performance testing without overhauls, will be considered to suggest a rational alternative to our existing maintenance activities. Because there had been no standard for function tests other than the METI inspection procedures in Japan, activities started for the development of Japanese Operation and Maintenance Guideline (hereinafter called the Japanese OM Guideline or the Guideline) for function tests and condition monitoring. The Japanese OM Guideline is not proclaimed for regulatory use, but the long-term objective is to provide a substantial basis to change the current maintenance activities including regulatory inspection. The Guideline is composed of five parts, which are general requirements, pumps, valves, snubbers and ECCS systems. This paper gives a summary of the ECCS part of the Japanese OM Guideline, in particular, focusing on the differences between the Guideline and the ASME O and M Standards, and topics or discussion during their establishment. (author)

Evaluation of precipitates used in strainer head loss testing: Part II. Precipitates by in situ aluminum alloy corrosion

International Nuclear Information System (INIS)

Bahn, Chi Bum; Kasza, Ken E.; Shack, William J.; Natesan, Ken; Klein, Paul

2011-01-01

Graphical abstract: Display Omitted Research highlights: → Sump strainer head loss testing to evaluate chemical effects. → Aluminum hydroxide precipitates by in situ Al alloy corrosion caused head loss. → Intermetallic particles released from Al alloy can also cause significant head loss. → When evaluating Al effect on head loss, intermetallics should be considered. - Abstract: Vertical loop head loss tests were performed with 6061 and 1100 aluminum (Al) alloy plates immersed in borated solution at pH = 9.3 at room temperature and 60 o C. The results suggest that the potential for corrosion of an Al alloy to result in increased head loss across a glass fiber bed may depend on its microstructure, i.e., the size distribution and number density of intermetallic particles that are present in Al matrix and FeSiAl ternary compounds, as well as its Al release rate. Per unit mass of Al removed from solution, the WCAP-16530 aluminum hydroxide (Al(OH) 3 ) surrogate was more effective in increasing head loss than the Al(OH) 3 precipitates formed in situ by corrosion of Al alloy. However, in choosing a representative amount of surrogate for plant specific testing, consideration should be given to the potential for additional head losses due to intermetallic particles and the apparent reduction in the effective solubility of Al(OH) 3 when intermetallic particles are present.

A Secure ECC-based RFID Mutual Authentication Protocol to Enhance Patient Medication Safety.

Science.gov (United States)

Jin, Chunhua; Xu, Chunxiang; Zhang, Xiaojun; Li, Fagen

2016-01-01

Patient medication safety is an important issue in patient medication systems. In order to prevent medication errors, integrating Radio Frequency Identification (RFID) technology into automated patient medication systems is required in hospitals. Based on RFID technology, such systems can provide medical evidence for patients' prescriptions and medicine doses, etc. Due to the mutual authentication between the medication server and the tag, RFID authentication scheme is the best choice for automated patient medication systems. In this paper, we present a RFID mutual authentication scheme based on elliptic curve cryptography (ECC) to enhance patient medication safety. Our scheme can achieve security requirements and overcome various attacks existing in other schemes. In addition, our scheme has better performance in terms of computational cost and communication overhead. Therefore, the proposed scheme is well suitable for patient medication systems.

AN ANALYSIS OF STUDENTS’ SPEAKING ABILITY IN ENGLISH CONVERSATION CLUB (ECC PROGRAM AT THE 3rd SEMESTER

Directory of Open Access Journals (Sweden)

M. Fadhly Farhy Abbas

2017-07-01

Full Text Available This research is based on students’ speaking ability who had followed the EnglishConversation Club (ECC program especially for the third semester of English Department. Thepurpose of this study was to analyze the students’ speaking ability at the 3rd semester in the EnglishConversation Club FKIP UNILAK Pekanbaru. The type of the research was mixed method in typeof explanatory design. The number of participant was 53 students. The researcher used twoinstruments, those were test and interview. In analyzing the data, it used in descriptive statistics.The result of the analysis showed that the average score of 3rd semester students’ speaking abilitywas 45.42. It can be concluded that the students’ speaking ability was categorized into failed . Thescore of Standard Deviation was 7.02, Variance was 49.30, and Range was 36 points . It meansthat the students’ speaking ability was homogeneous. According to the Z-Score, it can be seen that49.06% students’ ability was higher than average and 50.94% students ability was below theaverage. In conclusion, the students’ ability in learning speaking English was failed, it had beenaffected by some factors, those were lack of vocabulary, grammar and motivation. It was supportedby the interview, eventhough the students’ perception to English Conversation Club (ECCprogram was positive, but in fact, the students’ frequency to speak English was seldom, they wereless practice speaking English everyday.Keywords : Speaking , English Conversation Club (ECC

Safety design/analysis and scenario for prevention of CDA with ECCS in lead-bismuth-cooled fast reactor

International Nuclear Information System (INIS)

Minoru, Takahashi; Vaclav, Dostal; Abu Khalid, Rivai; Novitrian; Yumi, Yamada

2007-01-01

Safety design has been developed to show safety feature of Pb-Bi-cooled direct contact boiling water small fast reactor (PBWFR). The core is designed to have negative void reactivity even if the entire core and upper plenum are voided by steam intrusion from above. In-vessel type control rod driving mechanisms are used to prevent control rods from accidental ejection due to high pressure in the reactor vessel. In cases of coolant leakage from reactor vessel and feed water pipes, Pb-Bi coolant level in the reactor vessel is kept at the required level for decay heat removal by means of closed type guard vessel. Dual pipes are adopted to avoid leak of water in the feedwater system. Pump trip in feedwater systems initiates loss of coolant flow (LOF) event, although there is no concern of loss of flow accident due to primary pump trip. Injection of high pressure water slows down the flow-coast-down of feedwater at the LOF event. It has been evaluated that the fuel temperature is kept lower than safety limits at the unprotected loss of flow and heat sink (ATWS). A scenario for prevention of the core disruptive accident (CDA) with the emergency core cooling system (ECCS) is examined. The reactor becomes super-critical when the reactor vessel is filled with water. It is necessary to use water with boric acid for the ECC system, and additional backup rods for sub-critical core in water injection. (authors)

Detection blockages and valve statues in natural gas pipelines

Energy Technology Data Exchange (ETDEWEB)

Dawson, Karl; Short, Gordon; Wang, Xuesong [Pipeline Engineering Ltd, North Yorkshire, (United Kingdom); Lennox, Barry; Lewis, Keith; Turner, John [University of Manchester, Manchester, (United Kingdom); Lewis, Chris [BP exploration, Aberdeen, (United Kingdom)

2010-07-01

Detecting features in pipelines containing flowing gas is difficult. This paper investigated a patented acoustic reflectometry technique for detecting defects in gas pipelines. The basic concept of this technique is to inject a pulse of sound into a pipeline and then measure the reflections produced while the signal travels along the length of the pipe. A modification in the internal section of the pipe will produce a reflection which, given with the speed of sound in the gas within the pipeline, provides the location of the feature. Laboratory tests on a 16m rigid PVC pipe and two field trials were undertaken to test this new method. The results showed that acoustic reflectometry can be used to identify features resulting from blockages and leakages. The field tests demonstrated that the method is capable of surveying both small and large diameter pipelines with lengths up to 10 km.

Water modelling studies of blockage with discrete permeabilities in an 11 pin geometry

International Nuclear Information System (INIS)

Robinson, D.P.

1977-06-01

A linear array of 11 pins, representing a radial section through a 325 pin bundle, has been used to investigate the effect of discrete permeabilities on the wake geometry behind a local blockage in water. Three series of experiments were performed in each of which a different position of the permeability was considered. The complex wake geometries, visualised by the injection of air, are shown to be controlled by the position of, and flowrate through the permeability. Good agreement is shown between the experimental flow patterns and predictions by SABRE 1. (author)

Scaled experiments using the helium technique to study the vehicular blockage effect on longitudinal ventilation control in tunnels

DEFF Research Database (Denmark)

Alva, Wilson Ulises Rojas; Jomaas, Grunde; Dederichs, Anne

2015-01-01

A model tunnel (1:30 compared to a standard tunnel section) with a helium-air smoke mixture was used to study the vehicular blockage effect on longitudinal ventilation smoke control. The experimental results showed excellent agreement with full-scale data and confirmed that the critical velocity...

Visualization of tumor blockage and rerouting of lymphatic drainage in penile cancer patients by use of SPECT/CT.

Science.gov (United States)

Leijte, Joost A P; van der Ploeg, Iris M C; Valdés Olmos, Renato A; Nieweg, Omgo E; Horenblas, Simon

2009-03-01

The reliability of sentinel node biopsy is dependent on the accurate visualization and identification of the sentinel node(s). It has been suggested that extensive metastatic involvement of a sentinel node can lead to blocked inflow and rerouting of lymph fluid to a "neo-sentinel node" that may not yet contain tumor cells, causing a false-negative result. However, there is little evidence to support this hypothesis. Recently introduced hybrid SPECT/CT scanners provide both tomographic lymphoscintigraphy and anatomic detail. Such a scanner enabled the present study of the concept of tumor blockage and rerouting of lymphatic drainage in patients with palpable groin metastases. Seventeen patients with unilateral palpable and cytologically proven metastases in the groin underwent bilateral conventional lymphoscintigraphy and SPECT/CT before sentinel node biopsy of the contralateral groin. The pattern of lymphatic drainage in the 17 palpable groin metastases was evaluated for signs of tumor blockage or rerouting. On the CT images, the palpable node metastases could be identified in all 17 groins. Four of the 17 palpable node metastases (24%) showed uptake of radioactivity on the SPECT/CT images. In 10 groins, rerouting of lymphatic drainage to a neo-sentinel node was seen; one neo-sentinel node was located in the contralateral groin. A complete absence of lymphatic drainage was seen in the remaining 3 groins. The concept of tumor blockage and rerouting was visualized in 76% of the groins with palpable metastases. Precise physical examination and preoperative ultrasound with fine-needle aspiration cytology may identify nodes with considerable tumor invasion at an earlier stage and thereby reduce the incidence of false-negative results.

Assessment of fuel damage of pool type research reactor in the case of fuel plates blockage

Energy Technology Data Exchange (ETDEWEB)

Jalil, Jafari; Samad, Khakshournia [AEOI, Karegar Ave. School of R and D of Nuclear Reactors and Accelerators, Teheran (Iran, Islamic Republic of); D' Auria, F. [Pisa Univ., DIMNP (Italy)

2007-07-01

Tehran Research Reactor (TRR) is a pool type 5 MW research reactor. It is assumed that external objects or debris that may fall down to reactor core cause obstruction of coolant flow through one of the fuel assemblies. Thermal hydraulic analysis of this event, using the RELAP5 system code has been studied. The reported transient is related to the partial and total obstruction of a single Fuel Element (FE) cooling channel of 27 FE equilibrium core of TRR. Such event constitutes a severe accident for this type of reactor since it may lead to local dryout and eventually to loss of the FE integrity. Two scenarios are analysed to emphasize the severity of the accident. The first one is a partial blockage of an average FE considering four different obstruction levels: 25%, 50%, 75% and 97% of nominal flow area. The second one is an extreme scenario consisting of total blockage of the same FE. This study constitutes the first step of a larger work which consists of performing a 3-dimensional simulation using the Best Estimate coupled code technique. However, as a first approach the instantaneous reactor power is derived through the point kinetic calculation included in the RELAP5 code. Main results obtained from the RELAP5 calculations are as following. First, in the case of flow blockage under 97% of the nominal flow area of an average FE, only an increase of the coolant and clad temperatures is observed without any consequences for the integrity of the FE. The mass flow rate remains sufficient to cool the clad safely. Secondly, in the case of total obstruction of the nominal flow area, it is seen that transient turns out to be a severe accident due to the dryout conditions are reached shortly and melting of the cladding occurs. Thirdly, the use of the point kinetic approach leads to conservative results. A best estimate simulation of such kind of transients requires the use of 3-dimensional kinetic calculations, which could be done using the current Coupled Codes

Blockage of progestin physiology disrupts ovarian differentiation in XX Nile tilapia (Oreochromis niloticus)

International Nuclear Information System (INIS)

Zhou, Linyan; Luo, Feng; Fang, Xuelian; Charkraborty, Tapas; Wu, Limin; Wei, Jing; Wang, Deshou

2016-01-01

Previous studies indicated that maturation inducing hormone, 17α, 20β-Dihydroxy-4-pregnen-3-one (DHP), probably through nuclear progestin receptor (Pgr), might be involved in spermatogenesis and oogenesis in fish. To further elucidate DHP actions in teleostean ovarian differentiation, we analyzed the expression of pgr in the ovary of Nile tilapia (Oreochromis niloticus), and performed RU486 (a synthetic Pgr antagonist) treatment in XX fish from 5 days after hatching (dah) to 120dah. Tilapia Pgr was abundantly expressed in the follicular cells surrounding oocytes at 30 and 90dah. Continuous RU486 treatment led to the blockage of oogenesis and masculinization of somatic cells in XX fish. Termination of RU486 treatment and maintenance in normal condition resulted in testicular differentiation, and estrogen compensation in RU486-treated XX fish successfully restored oogenesis. In RU486-treated XX fish, transcript levels of female dominant genes were significantly reduced, while male-biased genes were evidently augmented. Meanwhile, both germ cell mitotic and meiotic markers were substantially reduced. Consistently, estrogen production levels were significantly declined in RU486-treated XX fish. Taken together, our data further proved that DHP, possibly through Pgr, might be essential in the ovarian differentiation and estrogen production in fish. - Highlights: • DHP plays a critical role in early stage oogenesis of XX tilapia. • Blockage of DHP actions by RU486 treatment led to masculinization and/or sex reversal in XX tilapia. • Both DHP and estrogen are indispensable for ovarian differentiation.

Blockage of progestin physiology disrupts ovarian differentiation in XX Nile tilapia (Oreochromis niloticus)

Energy Technology Data Exchange (ETDEWEB)

Zhou, Linyan; Luo, Feng; Fang, Xuelian [Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, 400715 (China); Charkraborty, Tapas [South Ehime Fisheries Research Center, Ehime University, Ainan, 798-4206 (Japan); Wu, Limin; Wei, Jing [Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, 400715 (China); Wang, Deshou, E-mail: wdeshou@swu.edu.cn [Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, School of Life Sciences, Southwest University, Chongqing, 400715 (China)

2016-04-22

Previous studies indicated that maturation inducing hormone, 17α, 20β-Dihydroxy-4-pregnen-3-one (DHP), probably through nuclear progestin receptor (Pgr), might be involved in spermatogenesis and oogenesis in fish. To further elucidate DHP actions in teleostean ovarian differentiation, we analyzed the expression of pgr in the ovary of Nile tilapia (Oreochromis niloticus), and performed RU486 (a synthetic Pgr antagonist) treatment in XX fish from 5 days after hatching (dah) to 120dah. Tilapia Pgr was abundantly expressed in the follicular cells surrounding oocytes at 30 and 90dah. Continuous RU486 treatment led to the blockage of oogenesis and masculinization of somatic cells in XX fish. Termination of RU486 treatment and maintenance in normal condition resulted in testicular differentiation, and estrogen compensation in RU486-treated XX fish successfully restored oogenesis. In RU486-treated XX fish, transcript levels of female dominant genes were significantly reduced, while male-biased genes were evidently augmented. Meanwhile, both germ cell mitotic and meiotic markers were substantially reduced. Consistently, estrogen production levels were significantly declined in RU486-treated XX fish. Taken together, our data further proved that DHP, possibly through Pgr, might be essential in the ovarian differentiation and estrogen production in fish. - Highlights: • DHP plays a critical role in early stage oogenesis of XX tilapia. • Blockage of DHP actions by RU486 treatment led to masculinization and/or sex reversal in XX tilapia. • Both DHP and estrogen are indispensable for ovarian differentiation.

Influence of partial blockage of a BWR bundle on heat transfer, cladding temperature, and quenching during bottom flooding or top spraying under simulated LOCA conditions

International Nuclear Information System (INIS)

Brand, B.; Gaul, H.P.; Sarkar, J.

1982-01-01

In a test facility with two parallel boiling water reactor fuel assemblies, experiments were carried out with top spray and bottom flooding, simulating loss-of-coolant accident (LOCA) conditions. The flow area restriction, caused by the ballooning of fuel rod cladding within one of the bundles, was provided by blockage plates, which had reductions of 37% in one case and in a second series 70% of the flow area. Test parameters were system pressure (1, 5, and 10 bars), spray (0.68 and 1.02 m 3 /h) and flooding rates (1.5,2, and 3.3 cm/s), power input (520 and 614 kW), and the initial cladding temperature (600 and 800 0 C at midplane) of the heaters. The test results showed no significant variations from those without blockage, except in the blocked region. An enhancement of heat transfer was observed in a close region downstream from the blockage in cases such as bottom flooding and top spray tests. The results will serve the purpose of code verification for reactor LOCA analysis

Correlated electron capture in the impact parameter and final projectile charge-state dependence of ECC cusp production in 0.53 MeV u-1 F8+ + Ne

International Nuclear Information System (INIS)

Skutlartz, A.; Hagmann, S.; Schmidt-Boecking, H.

1988-01-01

The impact parameter dependence of ECC cusp electron production in collisions of fast, highly charged ions with atoms is investigated by measuring the scattered projectiles in coincidence with cusp electrons emitted at 0 0 with respect to the beam axis. The absolute probabilities for ECC cusp production show a maximum at b ≅ 0.10 au, decrease strongly for smaller impact parameters and more gently toward larger impact parameters. In addition the final charge state of the scattered projectile is also determined simultaneously for each collision event. The probabilities, as a function of the projectile final charge state, are large for the case where at least one or more electrons are simultaneously captured into bound states of the projectile, but are surprisingly small for collisions in which a projectile did not capture an electron into a bound state. (author)

Percolation blockage: A process that enables melt pond formation on first year Arctic sea ice

Science.gov (United States)

Polashenski, Chris; Golden, Kenneth M.; Perovich, Donald K.; Skyllingstad, Eric; Arnsten, Alexandra; Stwertka, Carolyn; Wright, Nicholas

2017-01-01

Melt pond formation atop Arctic sea ice is a primary control of shortwave energy balance in the Arctic Ocean. During late spring and summer, the ponds determine sea ice albedo and how much solar radiation is transmitted into the upper ocean through the sea ice. The initial formation of ponds requires that melt water be retained above sea level on the ice surface. Both theory and observations, however, show that first year sea ice is so highly porous prior to the formation of melt ponds that multiday retention of water above hydraulic equilibrium should not be possible. Here we present results of percolation experiments that identify and directly demonstrate a mechanism allowing melt pond formation. The infiltration of fresh water into the pore structure of sea ice is responsible for blocking percolation pathways with ice, sealing the ice against water percolation, and allowing water to pool above sea level. We demonstrate that this mechanism is dependent on fresh water availability, known to be predominantly from snowmelt, and ice temperature at melt onset. We argue that the blockage process has the potential to exert significant control over interannual variability in ice albedo. Finally, we suggest that incorporating the mechanism into models would enhance their physical realism. Full treatment would be complex. We provide a simple temperature threshold-based scheme that may be used to incorporate percolation blockage behavior into existing model frameworks.

Experiment data report for Semiscale Mod-1 Test S-05-1 (alternate ECC injection test)

International Nuclear Information System (INIS)

Feldman, E.M.; Patton, M.L. Jr.; Sackett, K.E.

1977-02-01

Recorded test data are presented for Test S-05-1 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-1 was conducted from initial conditions of 2263 psia and 544 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the vessel lower plenum to simulate emergency core coolant injection in a PWR, with the flow rate based on system volume scaling

Stress analysis for CANDU reactor structure assembly following a postulated p/t, c/t rupture after flow blockage

Energy Technology Data Exchange (ETDEWEB)

Soliman, S A; Lee, T; Ibrahim, A M; Hodgson, S [Atomic Energy of Canada Ltd., Saskatoon, SK (Canada)

1996-12-31

This paper describes the collapse load calculations for the reactor structure assembly under the postulated fuel channel flow blockage Level D (faulted) loading condition. Under the flow blockage condition, the primary coolant flow path is obstructed between the inlet and outlet feeder connections to the headers. This, in turn, is postulated to cause the pressure tube and calandria tube to rupture and release hot molten fuel into the moderator, producing a hydrodynamic transient within the calandria shell. The most severe hydrodynamic loads occur within a fraction of a second (0.14 second). The peak pressure for the limiting case scenario for Level D condition is 120 psig, due to a single channel failure event. Under this accident condition, it is shown that the reactor structure assembly can withstand the pressure transient and the structural integrity of the core is assured. A finite element model is generated and used to calculate the minimum collapse load. The ANSYS code is used with element type Stif-43 for elastic/plastic, large deformation and small strain analysis. (author). 1 ref., 3 tabs., 9 figs.

Stress analysis for CANDU reactor structure assembly following a postulated p/t, c/t rupture after flow blockage

International Nuclear Information System (INIS)

Soliman, S.A.; Lee, T.; Ibrahim, A.M.; Hodgson, S.

1995-01-01

This paper describes the collapse load calculations for the reactor structure assembly under the postulated fuel channel flow blockage Level D (faulted) loading condition. Under the flow blockage condition, the primary coolant flow path is obstructed between the inlet and outlet feeder connections to the headers. This, in turn, is postulated to cause the pressure tube and calandria tube to rupture and release hot molten fuel into the moderator, producing a hydrodynamic transient within the calandria shell. The most severe hydrodynamic loads occur within a fraction of a second (0.14 second). The peak pressure for the limiting case scenario for Level D condition is 120 psig, due to a single channel failure event. Under this accident condition, it is shown that the reactor structure assembly can withstand the pressure transient and the structural integrity of the core is assured. A finite element model is generated and used to calculate the minimum collapse load. The ANSYS code is used with element type Stif-43 for elastic/plastic, large deformation and small strain analysis. (author). 1 ref., 3 tabs., 9 figs

FPGA implementation of PCI to CAMAC interface for Embedded CAMAC Controller (ECC)

International Nuclear Information System (INIS)

Jha, K.; Behere, Anita; Ghodgaonkar, M.D.

2005-01-01

CAMAC controllers are used for control systems and nuclear physics experiments. Control applications need more number of physically distributed crates with regular scanning of all the parameters, the control being with a centralized computer. On the other hand, nuclear physics experiments need a high throughput with a large number of parameters in one or more crates. The nature of events is random hence buffering of data in LIST mode acquisition is needed. For a large number of parameters, this translates to high transfer rate. Hence it is essential that the CAMAC readout time is minimized and also the data transfer speed is improved to achieve maximum effective throughput. The ECC is designed to achieve these objectives using an embedded controller with PC architecture having PCI bus as interface for add on logic. The PCI Add-on to CAMAC interface protocol has been implemented in an AL TERA FPGA and all the functionality coded in VHDL. This paper discusses the design aspects of the FPGA implementation of the PCI to CAMAC interface. (author)

Effect of extradural blockage upon glucose and urea kinetics in surgical patients

Energy Technology Data Exchange (ETDEWEB)

Shaw, J.H.; Galler, L.; Holdaway, I.M.; Holdaway, C.M.

1987-09-01

We have determined the metabolic effects induced by the use of extradural blockage with 0.5 per cent bupivacaine hydrochloride in a group of surgical patients. Turnover rates of glucose and urea were determined isotopically using radioisotopes and studies were performed both in the basal state and during total parenteral nutrition. In the basal state, extradural blockade resulted in a decrease in the turnover rates of both glucose and urea. In addition, when extradural blockade was instituted while the patients were receiving total parenteral nutrition, there was also a significant fall in glucose turnover. We conclude that the use of extradural blockade is effective as a means of conserving bodily resources in surgical patients both in the basal state and during total parenteral nutrition.

Effect of extradural blockage upon glucose and urea kinetics in surgical patients

International Nuclear Information System (INIS)

Shaw, J.H.; Galler, L.; Holdaway, I.M.; Holdaway, C.M.

1987-01-01

We have determined the metabolic effects induced by the use of extradural blockage with 0.5 per cent bupivacaine hydrochloride in a group of surgical patients. Turnover rates of glucose and urea were determined isotopically using radioisotopes and studies were performed both in the basal state and during total parenteral nutrition. In the basal state, extradural blockade resulted in a decrease in the turnover rates of both glucose and urea. In addition, when extradural blockade was instituted while the patients were receiving total parenteral nutrition, there was also a significant fall in glucose turnover. We conclude that the use of extradural blockade is effective as a means of conserving bodily resources in surgical patients both in the basal state and during total parenteral nutrition

Preliminary test conditions for KNGR SBLOCA DVI ECCS performance test

International Nuclear Information System (INIS)

Bae, Kyoo Whan; Song, Jin Ho; Chung, Young Jong; Sim, Suk Ku; Park, Jong Kyun

1999-03-01

The Korean Next Generation Reactor (KNGR) adopts 4-train Direct Vessel Injection (DVI) configuration and injects the safety injection water directly into the downcomer through the 8.5'' DVI nozzle. Thus, the thermal hydraulic phenomena such as ECCS mixing and bypass are expected to be different from those observed in the cold leg injection. In order to investigate the realistic injection phenomena and modify the analysis code developed in the basis of cold leg injection, thermal hydraulic test with the performance evaluation is required. Preliminarily, the sequence of events and major thermal hydraulic phenomena during the small break LOCA for KNGR are identified from the analysis results calculated by the CEFLASH-4AS/REM. It is shown from the analysis results that the major transient behaviors including the core mixture level are largely affected by the downcomer modeling. Therefore, to investigate the proper thermal hydraulic phenomena occurring in the downcomer with limited budget and time, the separate effects test focusing on this region is considered to be effective and the conceptual test facility based on this recommended. For this test facility the test initial and boundary conditions are developed using the CEFLASH-4AS/REM analysis results that will be used as input for the preliminary test requirements. The final test requirements will be developed through the further discussions with the test performance group. (Author). 10 refs., 18 tabs., 4 figs

Numerical simulation of fuel assembly thermohydraulics of fast reactors with the partial blockage of cross section under the coolant

International Nuclear Information System (INIS)

Zhukov, A.V.; Sorokin, A.P.

2000-01-01

The problems of numerical modeling of thermohydraulics in assembly of fuel elements of fast reactors with the partial blockage of cross-section under the coolant are considered. The information about existing codes constructed on use of subchannel technique and model of porous body are presented. The results of calculation obtained by these codes are presented. (author)

Safety verification for the ECCS driven by the electrically 4 trains during LBLOCA reflood phase using ATLAS

International Nuclear Information System (INIS)

Park, Yusun; Park, Hyun-sik; Kang, Kyoung-ho; Choi, Nam-hyun; Min, Kyoung-ho; Choi, Ki-yong

2014-01-01

Highlights: • Safety improvement by adopting 4 train emergency core cooling system was validated experimentally. • General thermal hydraulic behaviors of the system during LBLOCA reflood phase were successfully demonstrated. • Key parameters such as the liquid levels, the PCTs, the quenching time, and the ECC bypass ratios were investigated. • Asymmetric effects of the different combination of safety injection were negligible during the reflood period. - Abstract: The APR1400 is equipped with four safety injection pumps driven by two emergency diesel generators. However, the design has been changed so that the four safety injection pumps are driven by 4 emergency diesel generators during the design certification process from the U.S. NRC. Thus, 4 safety injection pumps (SIPs) are completely independent electrically and mechanically and three safety injection pumps are available in a single failure condition. This design change could have a certain effects on the thermal-hydraulic phenomenon occurring in the downcomer region during the late reflood phase of a large break loss of coolant accident (LBLOCA). Thus, in this study, a verification experiment for the reflood phase of a LBLOCA was performed to evaluate the core cooling performance of the 4 train emergency core cooling system (ECCS) with an assumption of a single failure. And the different combinations of three SIPs positions were tested to investigate the asymmetric effects on the reactor core cooling performance. The overall experimental results revealed the typical thermal–hydraulic trends expected to occur during the reflood phase of a large-break LOCA scenario for the APR1400. Experiment with the injection of three SIPs showed a faster core quenching time and lower bypass ratio than that of the case in which two SIPs were injected. The RPV wall temperature distributions showed the similar trend in spite of the different SIP combinations

Experiment data report for Semiscale Mod-1 Test S-05-5 (alternate ECC injection test)

International Nuclear Information System (INIS)

Collins, B.L.; Patton, M.L. Jr.; Sackett, K.E.

1977-04-01

Recorded test data are presented for Test S-05-5 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-5 was conducted from initial conditions of 2263 psia and 537 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg of the intact and broken loops to simulate emergency core coolant injection in a PWR. The upper plenum was vented through a reflood bypass line interconnecting the hot and cold legs of the broken loop

Large break LOCA analysis for retrofitted ECCS at MAPS using modified computer code ATMIKA

International Nuclear Information System (INIS)

Singhal, Mukesh; Khan, T.A.; Yadav, S.K.; Pramod, P.; Rammohan, H.P.; Bajaj, S.S.

2002-01-01

Full text: Computer code ATMIKA which has been used for thermal hydraulic analysis is based on unequal velocity equal temperature (UVET) model. Thermal hydraulic transient was predicted using three conservation equations and drift flux model. The modified drift flux model is now able to predict counter current flow and the relative velocity in vertical channel more accurately. Apart from this, stratification model is also introduced to predict the fuel behaviour under stratified condition. Many more improvements were carried out with respect to solution of conservation equation, heat transfer package and frictional pressure drop model. All these modifications have been well validated with published data on RD-12/RD-14 experiments. This paper describes the code modifications and also deals with the application of the code for the large break LOCA analysis for retrofitted emergency core cooling system (ECCS) being implemented at Madras Atomic Power Station (MAPS). This paper also brings out the effect of accumulator on stratification and fuel behaviour

RBMK fuel channel blockage analysis by MCNP5, DRAGON and RELAP5-3D codes

International Nuclear Information System (INIS)

Parisi, C.; D'Auria, F.

2007-01-01

The aim of this work was to perform precise criticality analyses by Monte-Carlo code MCNP5 for a Fuel Channel (FC) flow blockage accident, considering as calculation domain a single FC and a 3x3 lattice of RBMK cells. Boundary conditions for MCNP5 input were derived by a previous transient calculation by state-of-the-art codes HELIOS/RELAP5-3D. In a preliminary phase, suitable MCNP5 models of a single cell and of a small lattice of RBMK cells were set-up; criticality analyses were performed at reference conditions for 2.0% and 2.4% enriched fuel. These analyses were compared with results obtained by University of Pisa (UNIPI) using deterministic transport code DRAGON and with results obtained by NIKIET Institute using MCNP4C. Then, the changes of the main physical parameters (e.g. fuel and water/steam temperature, water density, graphite temperature) at different time intervals of the FC blockage transient were evaluated by a RELAP5-3D calculation. This information was used to set up further MCNP5 inputs. Criticality analyses were performed for different systems (single channel and lattice) at those transient' states, obtaining global criticality versus transient time. Finally the weight of each parameter's change (fuel overheating and channel voiding) on global criticality was assessed. The results showed that reactivity of a blocked FC is always negative; nevertheless, when considering the effect of neighboring channels, the global reactivity trend reverts, becoming slightly positive or not changing at all, depending in inverse relation to the fuel enrichment. (author)

Simulation of channel blockage for the IEA-R1 research reactor using RELAP/MOD 3

International Nuclear Information System (INIS)

Oliveira, Eduardo C.F. de; Castrillo, Lazara Silveira

2015-01-01

Research reactors have great importance in the area of nuclear technology, such as radioisotope production, research in nuclear physics, development of new technologies and staff training for reactor operation. The IEA-R1 is a Brazilian research reactor type pool, located at the IPEN (Instituto de Pesquisas Energeticas e Nucleares). In this work is simulated with computer code RELAP5 / MOD 3.3.2 gamma, the effect caused by partial and complete blockage of a channel in MTR fuel element of the IEA-R1 core, in order to analyzed the thermal hydraulic parameters on adjacent channels. (author)

Simulation of channel blockage for the IEA-R1 research reactor using RELAP/MOD 3

Energy Technology Data Exchange (ETDEWEB)

Oliveira, Eduardo C.F. de; Castrillo, Lazara Silveira, E-mail: ecfoliveira@hotmail.com, E-mail: lazara.castrillo@upe.br [Universidade de Pernambuco (UPE), Recife, PE (Brazil). Escola Politecnica de Pernambuco

2015-07-01

Research reactors have great importance in the area of nuclear technology, such as radioisotope production, research in nuclear physics, development of new technologies and staff training for reactor operation. The IEA-R1 is a Brazilian research reactor type pool, located at the IPEN (Instituto de Pesquisas Energeticas e Nucleares). In this work is simulated with computer code RELAP5 / MOD 3.3.2 gamma, the effect caused by partial and complete blockage of a channel in MTR fuel element of the IEA-R1 core, in order to analyzed the thermal hydraulic parameters on adjacent channels. (author)

Pressure vessel fracture studies pertaining to a PWR LOCA-ECC thermal shock: experiments TSE-1 and TSE-2

International Nuclear Information System (INIS)

Cheverton, R.D.

1976-09-01

The LOCA-ECC Thermal Shock Program was established to investigate the potential for flaw propagation in pressurized-water reactor (PWR) vessels during injection of emergency core coolant following a loss-of-coolant accident. Studies thus far have included fracture mechanics analyses of typical PWRs, the design and construction of a thermal shock test facility, determination of material properties for test specimens, and two thermal shock experiments with 0.53-m-OD (21-in.) by 0.15-m-wall (6-in.) cylindrical test specimens. The PWR calculations indicated that under some circumstances crack propagation could be expected and that experiments should be conducted for cracks that would have the potential for propagation at least halfway through the wall

Estimated net value and uncertainty for automating ECCS switchover at PWRs

International Nuclear Information System (INIS)

Walsh, B.; Brideau, J.; Comes, L.; Darby, J.; Guttmann, H.; Sciacca, F.; Souto, F.; Thomas, W.; Zigler, G.

1996-02-01

Question for resolution of Generic Safety Issue No. 24 is whether or not PWRs that currently rely on a manual system for ECCS switchover to recirculation should be required to install an automatic system. Risk estimates are obtained by reevaluating the contributions to core damage frequencies (CDFs) associated with failures of manual and semiautomatic switchover at a representative PWR. This study considers each separate instruction of the corresponding emergency operating procedures (EOPs), the mechanism for each control, and the relation of each control to its neighbors. Important contributions to CDF include human errors that result in completely coupled failure of both trains and failure to enter the required EOP. It is found that changeover to a semiautomatic system is not justified on the basis of cost-benefit analysis: going from a manual to a semiautomatic system reduces the CDF by 1.7 x 10 -5 per reactor-year, but the probability that the net cost of the modification being less than $1, 000 per person-rem is about 20% without license renewal. Scoping analyses, using optimist assumptions, were performed for a changeover to a semiautomatic system with automatic actuation and to a fully automatic system; in these cases the probability of a net cost being less than $1,000/person-rem is about 50% without license renewal and over 95% with license renewal

EDF feedback on recent EPRI SGOG SG chemical cleanings applications for TSP blockage reduction and heat transfer recover

International Nuclear Information System (INIS)

Dijoux, M.; De Bouvier, O.; Mercier, S.; Pages, D.; Bretelle, J.-L.; Leclercq, P.; Mermillod, A.

2010-01-01

Between 2007 and 2008, six Steam Generators Chemical Cleanings (SGCC) with the inhibitor free high temperature process were applied on EDF PWR units. The main goal was to reduce the excessive Tube Support Plate blockages observed on several units of the EDF fleet and the consequences on wide range levels and the risk of tube cracks. The heat transfer recovery was the second objective. Despite the correct results obtained, the corrosion impact of the high temperature process on internal metallic surfaces, higher than expected, and the environmental issues led EDF to move to a new cleaning process. The low temperature process developed by EPRI SGOG and applied for many years was selected for the same purpose. Some qualification laboratory tests were performed by Dominion Engineering Inc (DEI) to demonstrate the innocuousness an the efficiency of the process to achieve these goals. The EPRI SGOG process was then applied seven times by Westinghouse on the EDF units Cruas 3, Cruas 2, Belleville 1, Cattenom 1, Cattenom 3, Chinon B3 and Cattenom 4 between 2008 and 2010. All these units operate from the initial start at low AVT pH 25 o C (9,2) in the secondary circuit. Due to copper presence in the deposits to remove, the cleaning sequence 'Copper - Iron - Copper steps' was performed each time. After a short description of the process, including the specific adaptation in France, lessons learned are reported in this paper in the following areas: process monitoring, corrosion, efficiency, liquid and gaseous wastes, chemical pollution during start-up. Based on the 3 first applications in 2008, some modifications of the process were implemented, particularly for the copper step. For the units cleaned, 1100 to 4500 kg of deposits per SG have been removed, including TS sludge lancing. The reduction of TSP blockages was satisfying. The effect on steam pressure improvement and the wide range level is then discussed. The paper concludes on EDF perspectives for soft

Chemical preventive remedies for steam generators fouling and tube support plate blockages

International Nuclear Information System (INIS)

Alves Vieira, M.; Mayos, M.; Coquio, N.; Fourcroy, H.; Battesti, P.

2010-01-01

In 2006, EDF identified on several PWR units broached hole blockage on the upper Steam Generator (SG) Tube Support Plates (TSP). TSP blockage often occurs in association with secondary fouling. The units with copper alloys materials are more affected due the applied low pH 25 o C (9.20) all volatile treatment (AVT). Carbon steels materials are less protected against flow accelerated corrosion (FAC) and therefore more corrosion products enter the SGs through the final feed water (FFW). In parallel of chemical cleanings to remove oxides deposits in SGs, EDF has defined a strategy to improve operating conditions. It mainly relies on the removal of copper alloys materials to implement a high pH AVT (9.60) as a preventive remedy. However for some plants, copper alloys removal is not straightforward due to environmental constraints. EDF must indeed manage the implementation of a biocide treatment needed in closed loop cooling systems (as copper has a bacteriostatic effect on micro-organisms) and more generally must comply with discharge authorisations for chemical conditioning reagents or biocide reagent. An alternative conditioning was tested on the Dampierre 4 unit in 2007/2008 during 6 months to assess if operating at 9.40 was acceptable regarding the impacts on copper alloys materials. The perspective would be to implement it in the units where no biocide treatment can be applied on a short term. In parallel, other chemical conditionings or additives will be implemented or tested. First of all, EDF will carry out a trial test with APA in order to assess its efficiency on the removal of oxides deposits through SG blowdown. On the other hand, AVT with high pH ethanolamine (ETA) will be implemented as an alternative of ammonia and morpholine conditioning on some chosen plants. Ethanolamine is selected as a way to mitigate FAC kinetics in two-phase flow areas (reheaters or moisture heater separator) or to limit liquid releases. This paper provides the lessons of the

Systematic evaluation program review of NRC Safety Topic VI-7.3 associated with the electrical, instrumentation and control portions of the ECCS actuation system for the Dresden II Nuclear Power Plant

International Nuclear Information System (INIS)

St Leger-Barter, G.

1980-11-01

This report documents the technical evaluation and review of NRC Safety Topic VI-7.A.3, associated with the electrical, instrumentation, and control portions of the classification of the ECCS actuation system for the Dresden II nuclear power plant, using current licensing criteria

Modeling of the acoustic boiling noise of sodium during an assembly blockage in sodium-cooled reactors

International Nuclear Information System (INIS)

Vanderhaegen, M.

2013-01-01

In the framework of the fourth generation of nuclear reactors safety requirements, the acoustic boiling detection is studied to detect subassembly blockages. Boiling, that might occur during subassembly blockages and that can lead to clad failure, generates hydrodynamic noise that can be related to the two-phase flow. A bubble dynamics study shows that the sound source during subassembly boiling is condensation. This particular phenomenon generates most noise as a high subcooling is present in the subassembly and because of the high thermal diffusivity of sodium. This result leads to an estimate of the form of the acoustic spectrum that will be filtered and amplified during propagation inside the liquid. And even though it is unlikely that bubbles will be present inside the subassembly, due to the very gradual temperature profile at the wall and due to the geometry that leads to a strong confinement of the vapor, the historical bubble dynamics approach gives some insight in previous measurements. Additionally, some hypotheses can be disproved. These theoretical ideas are validated with a small water experiment, yet it also shows that a simple experience in sodium doesn't lead to a better knowledge of the acoustic source. A theoretical analysis also revealed that a realistic experiment with a simulant fluid, such as water or mercury, isn't representative. A similar conclusion is obtained when studying cavitation as a simulant acoustic source. As such, the acoustic detection of boiling, in comparison with other detection systems, isn't sufficiently developed yet to be applied as a reactor protective system. (author) [fr

Exxon Nuclear WREM-based NJP-BWR ECCS evaluation model and example application to the Oyster Creek Plant

International Nuclear Information System (INIS)

Krysinski, T.L.; Bjornard, T.A.; Steves, L.H.

1975-01-01

A proposed integrated ECCS model for non-jet pump boiling water reactors is presented, using the RELAP4-EM/BLOWDOWN and RELAP4-EM/SMALL BREAK portions of the Exxon Nuclear WREM-based Generic PWR Evaluation Model coupled with the ENC NJP-BWR Fuel Heatup Model. The results of the application of the proposed model to Oyster Creek are summarized. The results of the break size sensitivity study using the proposed model for the Oyster Creek Plant are presented. The application of the above results yielded the MAPLHGR curves. Included are a description of the proposed non-jet pump boiling water reaction evaluation model, justification of its conformance with TOCFR50, Appendix K, the adopted Oyster Creek plant model, and results of the analysis and sensitivity studies. (auth)

Experiment data report for Semiscale Mod-1 Test S-05-3 (alternate ECC injection test)

International Nuclear Information System (INIS)

Feldman, E.M.; Patton, M.L. Jr.; Sackett, K.E.

1977-03-01

Recorded test data are presented for Test S-05-3 of the Semiscale Mod-1 alternate ECC injection test series. These tests are among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor (PWR) system. Test S-05-3 was conducted from initial conditions of 2263 psia and 545 0 F to investigate the response of the Semiscale Mod-1 system to a depressurization and reflood transient following a simulated double-ended offset shear of the cold leg broken loop piping. During the test, cooling water was injected into the cold leg sides of the intact and broken loops and into the vessel upper plenum to simulate emergency core coolant injection in a PWR. For Test S-05-3, specifically the effects of upper plenum coolant injection on core thermal and system response were being investigated

Thermal-Hydraulic Analysis of Coolant Flow Decrease in Fuel Channels of Smolensk-3 RBMK during GDH Blockage Event

International Nuclear Information System (INIS)

Costa, A. L.; Cherubini, M.; D'Auria, F.; Giannotti, W.; Moskalev, A.

2007-01-01

One of the transients that have received considerable attention in the safety evaluation of RBMK reactors is the partial break of a group distribution header (GDH). The coolant flow rate blockage in one GDH might lead to excessive heat-up of the pressure tubes and can result in multiple fuel channels (FC) ruptures. In this work, the GDH flow blockage transient has been studied considering the Smolensk-3 RBMK NPP (nuclear power plant). In the RBMK, each GDH distributes coolant to 40-43 FC. To investigate the behavior of each FC belonging to the damaged GDH and to have a more realistic trend, one (affected) GDH has been schematised with its forty-two FC, one by one. The calculations were performed using the 0-D NK (neutron kinetic) model of the RELAP5-3.3 stand-alone code. The results show that, during the event, the mass flow rate is disturbed differently according to the power distribution established for each FC in the schematization. The start time of the oscillations in mass flow rate depends strongly on the attributed power to each FC. It was also observed that, during the event, the fuel channels at higher thermal power values tend to undergo first cladding rupture leaving the reactor to scram and safeguarding all the other FCs connected to the affected GDH.

A robust ECC based mutual authentication protocol with anonymity for session initiation protocol.

Science.gov (United States)

Mehmood, Zahid; Chen, Gongliang; Li, Jianhua; Li, Linsen; Alzahrani, Bander

2017-01-01

Over the past few years, Session Initiation Protocol (SIP) is found as a substantial application-layer protocol for the multimedia services. It is extensively used for managing, altering, terminating and distributing the multimedia sessions. Authentication plays a pivotal role in SIP environment. Currently, Lu et al. presented an authentication protocol for SIP and profess that newly proposed protocol is protected against all the familiar attacks. However, the detailed analysis describes that the Lu et al.'s protocol is exposed against server masquerading attack and user's masquerading attack. Moreover, it also fails to protect the user's identity as well as it possesses incorrect login and authentication phase. In order to establish a suitable and efficient protocol, having ability to overcome all these discrepancies, a robust ECC-based novel mutual authentication mechanism with anonymity for SIP is presented in this manuscript. The improved protocol contains an explicit parameter for user to cope the issues of security and correctness and is found to be more secure and relatively effective to protect the user's privacy, user's masquerading and server masquerading as it is verified through the comprehensive formal and informal security analysis.

A robust ECC based mutual authentication protocol with anonymity for session initiation protocol.

Directory of Open Access Journals (Sweden)

Zahid Mehmood

Full Text Available Over the past few years, Session Initiation Protocol (SIP is found as a substantial application-layer protocol for the multimedia services. It is extensively used for managing, altering, terminating and distributing the multimedia sessions. Authentication plays a pivotal role in SIP environment. Currently, Lu et al. presented an authentication protocol for SIP and profess that newly proposed protocol is protected against all the familiar attacks. However, the detailed analysis describes that the Lu et al.'s protocol is exposed against server masquerading attack and user's masquerading attack. Moreover, it also fails to protect the user's identity as well as it possesses incorrect login and authentication phase. In order to establish a suitable and efficient protocol, having ability to overcome all these discrepancies, a robust ECC-based novel mutual authentication mechanism with anonymity for SIP is presented in this manuscript. The improved protocol contains an explicit parameter for user to cope the issues of security and correctness and is found to be more secure and relatively effective to protect the user's privacy, user's masquerading and server masquerading as it is verified through the comprehensive formal and informal security analysis.

Water-hammer in the cold leg during an SBLOCA due to cold ECCS injection

International Nuclear Information System (INIS)

Ortiz, M.G.; Ghan, L.S.

1991-01-01

Water-hammer might occur in the cold leg of pressurized water reactors (PWR) during small break loss-of-coolant accidents (SBLOCA's), when cold emergency core cooling system (ECCS) water is injected into a pipe that may be partially filled with saturated steam. The water may mix with the steam and cause it to condense abruptly. Depending on the flow regime present, slugs of liquid may then be accelerated towards each other or against the piping structure. The possibility of this phenomenon is of concern to us because it may become a dominant phenomenon and change the character of the transient. In performing the code scaling, applicability, and uncertainty study (CSAU) on a SBLOCA scenario, we had to examine the possibility that the transient being analyzed could experience water-hammer and thus depart from the scope of the study. Two criteria for water-hammer initiation were investigated and tested using a RELAP5/MOD3 simulation of the transient. Our results indicated a very low likelihood of occurrence of the phenomenon. 8 refs., 6 figs

β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

Directory of Open Access Journals (Sweden)

Zhang Dong

2011-11-01

Full Text Available Abstract Background Smoking and stress, pancreatic cancer (PanCa risk factors, stimulate nitrosamine 4-(methylnitrosamino-1-(3-pyridyl-1-butanone (NNK and catecholamines production respectively. NNK and catecholamine bind the β-adrenoceptors and induce PanCa cell proliferation; and we have previously suggested that β-adrenergic antagonists may suppress proliferation and invasion and stimulate apoptosis in PanCa. To clarify the mechanism of apoptosis induced by β2-adrenergic antagonist, we hypothesize that blockage of the β2-adrenoceptor could induce G1/S phase arrest and apoptosis and Ras may be a key player in PanCa cells. Results The β1 and β2-adrenoceptor proteins were detected on the cell surface of PanCa cells from pancreatic carcinoma specimen samples by immunohistochemistry. The β2-adrenergic antagonist ICI118,551 significantly induced G1/S phase arrest and apoptosis compared with the β1-adrenergic antagonist metoprolol, which was determined by the flow cytometry assay. β2-adrenergic antagonist therapy significantly suppressed the expression of extracellular signal-regulated kinase, Akt, Bcl-2, cyclin D1, and cyclin E and induced the activation of caspase-3, caspase-9 and Bax by Western blotting. Additionally, the β2-adrenergic antagonist reduced the activation of NFκB in vitro cultured PanCa cells. Conclusions The blockage of β2-adrenoceptor markedly induced PanCa cells to arrest at G1/S phase and consequently resulted in cell death, which is possibly due to that the blockage of β2-adrenoceptor inhibited NFκB, extracellular signal-regulated kinase, and Akt pathways. Therefore, their upstream molecule Ras may be a key factor in the β2-adrenoceptor antagonist induced G1/S phase arrest and apoptosis in PanCa cells. The new pathway discovered in this study may provide an effective therapeutic strategy for PanCa.

Verification of LOCA/ECCS analysis codes ALARM-B2 and THYDE-B1 by comparison with RELAP4/MOD6/U4/J3

International Nuclear Information System (INIS)

Shimizu, Takashi

1982-08-01

For a verification study of ALARM-B2 code and THYDE-B1 code which are the component of the JAERI code system for evaluation of BWR ECCS performance, calculations for typical small and large break LOCA in BWR were done, and compared with those by RELAP4/MOD6/U4/J3 code. This report describes the influences of differences between the analytical models incorporated in the individual code and the problems identified by this verification study. (author)

Numerical Experimentation to Develop Design and Operational Parameters for Skimming Wells: A Case Study of the Chaj Doab of Punjab, Pakistan

Directory of Open Access Journals (Sweden)

Muhammad Aslam

2015-07-01

Full Text Available In the present study, MODFLOW-MT3D groundwater model was employed to perform numerical experimentation to develop design and operational parameters for SW (Skimming Wells based on hydrogeology and groundwater salinity conditions of Chaj Doab, Punjab, Pakistan. Numerical experimentation resulted in: (i a 1-strainer SW with discharge of 14 l/s (litres per second and penetration of 30% resulted in more saltwater upconing at 8 hours/day well operation compared to that occurred at 4 hours/day operation; (ii a 1-strainer well with penetration of 30% and operation of 8 hours/day caused higher saltwater upconing at 14 l/s discharge compared to that at 9 l/s discharge; (iii a 4-strainer well with penetration of 30% and operation of 8 hours/day also caused more saltwater upconing at 14 l/s well discharge compared to that at 9 l/s discharge. Similar trend was found for a 8- strainer well; and (iv 1- or 4- or 8-strainer well with 30-60% penetration, 9-14 l/s discharge and 4-8 hours/day operation could provide pumped groundwater of salinity less than 1000 ppm. Considering hydro-chemical performance and costs of wells, a 4-strainer well with 30% penetration, 9- 14 l/s discharge and 4-8 hours/day operation is recommended to skim groundwater of salinity less than 1000 ppm in Chaj Doab of Punjab, Pakistan

Safety measure S 05 'Sump clogging risk'

International Nuclear Information System (INIS)

Murani, J.

1997-01-01

This paper dealt with the safety measure S 05 'Sump clogging risk'. Problem specification contains: (1) to determine the effective strainer surface needed to be available in order to assure sufficient coolant volumes for a reliable operation of emergency systems; (2) to determine quantity and structure of insulation material which can be dislodged and can induce strained clogging; (3) to verify properties of insulation material with regard to its thermal degradation as a result of a long-term reactor unit operation; (4) to design and erect strainers so to assure sufficient congestion of emergency pump intake lines in post-accident regimes; (5) to design seismically resistant strainers with a capability to resist dynamic impacts from adjacent piping; (6) to assure monitoring of the strainer condition in real time with signals sent to the main control room

Evaluation of chemical phenomena that could have an effect on the performance of recirculation strainers in a Ringhals PWR

International Nuclear Information System (INIS)

Liljenzin, Jan-Olov

2005-01-01

An evaluation has been made of the various chemical phenomena that could have an effect on the performance of recirculation strainers after a LOCA in a PWR. Values of pH and concentrations in the water at the bottom of the containment have been calculated as functions of time and temperature for a postulated LOCA. The behaviour of glass wool insulation, its dissolution, and precipitation of amorphous silic acid have been evaluated. Also the corrosion of galvanized surfaces has been considered. Dissolution of zinc by hot boric acid solution can lead to a later precipitation of amorphous zinc hydroxide or phosphate when pH increases and temperature drops. Also a possible growth of microorganisms is discussed. A rough classification of the various phenomena possible along a simplified time scale yields the following conclusions: Hours after the beginning of the LOCA: Precipitation of zinc hydroxide and/or phosphate. Dissolution of glass wool giving rise to an increasing concentration of silic acid in the water. Days after the beginning of the LOCA: Continued dissolution of glass wool and increasing concentration of silica in the water. Perhaps a precipitation of phosphates or carbonates of the metal ions released during dissolution of glass wool. Weeks after the beginning of the LOCA: Continued slow dissolution of glass wool leading to a risk of precipitation of amorphous silica. Perhaps a precipitation of phosphates or carbonates of the metal ions released during dissolution of glass wool. Initial growth of microorganisms in the water and on surfaces after mutations and adaptation to the existing environment. Months after the beginning of the LOCA: Continued slow dissolution of glass wool leading to a risk of precipitation of amorphous silica. Perhaps a precipitation of phosphates or carbonates of the metal ions released during dissolution of glass wool. Continued growth of adapted microorganisms

Temperature fluctuations: an assessment of their use in the detection of fast reactor coolant blockages

International Nuclear Information System (INIS)

Greef, C.P.

1979-01-01

The temperature noise technique for the detection of local blockages in fast reactor subassemblies is discussed. The main factors involved in an assessment of the technique are outlined and the experimental and theoretical work that has been carried out at BNL on the various aspects of the problem is described. It is concluded that blockings appreciably smaller than those predicted to produce boiling should be detectable against a background noise level due to subassembly power tilts, on a time scale giving protection against rapidly developing incidents. Further work required to increase confidence in the application of the technique to the reactor is outlined, including measurements in fully representative geometries, data from sodium rigs and further information on reactor background noise levels. (Auth.)

Blockage of the pyrimidine biosynthetic pathway affects riboflavin production in Ashbya gossypii.

Science.gov (United States)

Silva, Rui; Aguiar, Tatiana Q; Domingues, Lucília

2015-01-10

The Ashbya gossypii riboflavin biosynthetic pathway and its connection with the purine pathway have been well studied. However, the outcome of genetic alterations in the pyrimidine pathway on riboflavin production by A. gossypii had not yet been assessed. Here, we report that the blockage of the de novo pyrimidine biosynthetic pathway in the recently generated A. gossypii Agura3 uridine/uracil auxotrophic strain led to improved riboflavin production on standard agar-solidified complex medium. When extra uridine/uracil was supplied, the production of riboflavin by this auxotroph was repressed. High concentrations of uracil hampered this (and the parent) strain growth, whereas excess uridine favored the A. gossypii Agura3 growth. Considering that the riboflavin and the pyrimidine pathways share the same precursors and that riboflavin overproduction may be triggered by nutritional stress, we suggest that overproduction of riboflavin by the A. gossypii Agura3 may occur as an outcome of a nutritional stress response and/or of an increased availability in precursors for riboflavin biosynthesis, due to their reduced consumption by the pyrimidine pathway. Copyright © 2014 Elsevier B.V. All rights reserved.

Protection system for minimizing the consequences of a flow blockage incident at a pool-type research reactor

International Nuclear Information System (INIS)

de Vries, J.W.; van Dam, H.; Gysler, G.

1990-01-01

Safety analysis activities were performed for the HOR, a pool-type research reactor with plate-type fuel elements and a maximum licensed power of 3 MW. Following internationally accepted guidelines, a wide variety of possible process disturbances has been considered. For the HOR the most aggravating accident conditions could result from a sudden flow blockage of cooling channels. If this event occurs in the high power density region of the core, a decrease of the hot channel flow either causes flow reversal or prompts burnout. Unless the reactor is scrammed in time, the fuel plates will heat up rapidly and local melting will occur with possible propagation of voiding and burnout to adjacent channels. In the analysis, melting of the cladding has been considered by using a simplified model approach. The number of voided coolant channels, as well as the propagation rate of fuel plates reaching locally the melting temperature, were calculated for different conditions of operation. In order to reduce the risk of a fuel melt accident occurring at the HOR, the protection system features a special design option. The system recognizes cooling channel voiding by detection of a sudden decrease of neutron flux. In the present work, it has been shown that a flow blockage incident can be detected in the early stages of development. Also, in accordance with the results of experimental tests, it can be concluded that in many cases melting of fuel plates will be effectively prevented. If such an accident occurs on a very fast time scale, at least the radiological consequences are significantly mitigated by preventing propagation, thus limiting the number of molten fuel plates

Experimental evaluation of blockage ratio and plenum evacuation system flow effects on pressure distribution for bodies of revolution in 0.1 scale model test section of NASA Lewis Research Center's proposed altitude wind tunnel

Science.gov (United States)

Burley, Richard R.; Harrington, Douglas E.

1987-01-01

An experimental investigation was conducted in the slotted test section of the 0.1-scale model of the proposed Altitude Wind Tunnel to evaluate wall interference effects at tunnel Mach numbers from 0.70 to 0.95 on bodies of revolution with blockage rates of 0.43, 3, 6, and 12 percent. The amount of flow that had to be removed from the plenum chamber (which surrounded the slotted test section) by the plenum evacuation system (PES) to eliminate wall interference effects was determined. The effectiveness of tunnel reentry flaps in removing flow from the plenum chamber was examined. The 0.43-percent blockage model was the only one free of wall interference effects with no PES flow. Surface pressures on the forward part of the other models were greater than interference-free results and were not influenced by PES flow. Interference-free results were achieved on the aft part of the 3- and 6-percent blockage models with the proper amount of PES flow. The required PES flow was substantially reduced by opening the reentry flaps.

Experimental study of the reflooding of a constricted tube in the REFLEX rig

International Nuclear Information System (INIS)

Denham, M.K.; Elliott, D.F.; Britton-Jones, K.A.

1982-08-01

The Winfrith experimental programme in support of the PWR is focussed on fuel thermal and hydraulic performance under hypothetical accident conditions, and includes studies of reflooding heat transfer of single tubes and fuel rod clusters under simulated accident conditions, aimed at improving understanding of the processes involved and providing data for code development and validation. The work described is part of a study of the possible effects of clad ballooning on ECCS effectiveness. During a large loss of coolant accident the primary circuit will depressurise and the core will overheat. The Zircaloy fuel cladding may swell, partially blocking the coolant passages by the formation of local ''balloons''. An experiment was carried out in the REFLEX single tube reflooding rig, to study, in a simple geometry, the effect of the partial blockage of the tube on the fluid flow and heat transfer during reflooding. The blockage consisted of a tapering entrance with a flow area 60 percent less than the unconstricted tube, and a tapering exit. The flow could be viewed through windows. 66 refloods were carried out over a pressure range of 1 to 4 bar. Results of these tests are presented. (U.K.)

The Sump Screen Clogging Issue in Belgium from the Standpoint of the Authorized Inspection Organisation (AIO) (AVN)

International Nuclear Information System (INIS)

Tombuyses, B.; Gelder, P. de; Vandewalle, A.

2004-01-01

All Belgian NPPs are PWRs. These PWRs have different containment designs and different sump designs. The four most recent units took RG 1.82 rev. 0 into account for the recirculation sump design. Several improvements were made in the framework of the first Periodic Safety Review to the oldest units such as enlargement of the sumps strainer in 1985, taking into account the requirements of RG 1.82 rev. 0. The problem of recirculation sump screen clogging due to the accumulation of insulation debris after an accident was also identified as a safety issue in the first Periodic Safety Review for Doel 3 and Tihange 2 and the second Periodic Safety Review for Doel 1 and 2 and Tihange 1, that started in the nineties. One of the purposes of the Periodic Safety Review being the justification of the safety level of the power plants with regard to the most recent safety rules and practices, the licensee was asked to review the characteristics of the sump strainers according to the revision 1 of the RG 1.82 (which referred to Nureg 0897 rev. 1). Later on, the Barsebaeck incident and the events leading to the NRC IN 93-34 showed that the conclusions of Nureg 0897 could underestimate the potential for loss of NPSH of the ECCS- and CSS-pumps. The issue was further examined and the AIO asked the licensee to continue efforts to recollect information. After issuance of the results from the parametric evaluation for pressurised water reactor recirculation sump performance (GSI-191) performed by LANL under NRC contract, the AIO asked the Belgian licensee in August 2002 to increase its efforts to investigate and to solve this issue. The requirements to the Licensee and the corresponding action plan as approved by the AIO are presented. Some significant lessons learned from the implementation of this action plan are discussed. (authors)

Repeated peritoneal catheter blockage caused by neurocysticercosis following ventriculoperitoneal shunt placement for hydrocephalus

Directory of Open Access Journals (Sweden)

Zhi Hua Li

2018-01-01

Full Text Available Cerebral cysticercosis is common, but the possibility for repeated occurrence of peritoneal catheter blockage caused by neurocysticercosis (NCC after two revisions following ventriculoperitoneal shunt placement for hydrocephalus is unusual. Herein, we describe one rare case in which peritoneal catheter revision was performed two times unsuccessfully. Endoscopic cysternostomy rather than peritoneal catheter adjustment was performed successfully, and histopathological examination of excised cystic samples confirmed NCC in our hospital. The present case highlights the need for awareness of NCC as a possible etiology of hydrocephalus, especially in developing countries. Uncommon findings in both lateral ventricles following low-field magnetic resonance imaging scans as well as the rarity of this infection involved in unusual location play important roles in misdiagnosis and incorrect treatment for hydrocephalus; thus, endoscopic cysternostomy, rather than multiple shunt adjustment of the peritoneal end, is recommended in the selected patient. To the best of our knowledge, this is the first report describing the misdiagnosis and inappropriate treatment of hydrocephalus caused by cerebral cysticercosis in China.

14 CFR 25.977 - Fuel tank outlet.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel tank outlet. 25.977 Section 25.977... STANDARDS: TRANSPORT CATEGORY AIRPLANES Powerplant Fuel System § 25.977 Fuel tank outlet. (a) There must be a fuel strainer for the fuel tank outlet or for the booster pump. This strainer must— (1) For...

14 CFR 29.977 - Fuel tank outlet.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel tank outlet. 29.977 Section 29.977... STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Fuel System § 29.977 Fuel tank outlet. (a) There must be a fuel strainer for the fuel tank outlet or for the booster pump. This strainer must— (1) For...

Using Proteomics to 1) Identify the Bone Marrow Homing Receptors Expressed on Human Hematopoietic Stem Cells and 2) Elucidate Critical Signaling Pathways Responsible for the Blockage of Hematopoietic Differentiation in Leukemia

KAUST Repository

Chin, Chee J.

2011-01-01

Successful hematopoiesis requires the trafficking of hematopoietic stem/progenitor cells (HSPCs) to their bone marrow (BM) niche, where they can differentiate to produce all blood lineages. Leukemia arises when there is a blockage of differentiation

14 CFR 23.977 - Fuel tank outlet.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel tank outlet. 23.977 Section 23.977... tank outlet. (a) There must be a fuel strainer for the fuel tank outlet or for the booster pump. This... damage any fuel system component. (b) The clear area of each fuel tank outlet strainer must be at least...

Functional blockage of EMMPRIN ameliorates atherosclerosis in apolipoprotein E-deficient mice.

Science.gov (United States)

Liu, Hong; Yang, Li-xia; Guo, Rui-wei; Zhu, Guo-Fu; Shi, Yan-Kun; Wang, Xian-mei; Qi, Feng; Guo, Chuan-ming; Ye, Jin-shan; Yang, Zhi-hua; Liang, Xing

2013-10-09

Extracellular matrix metalloproteinase inducer (EMMPRIN), a 58-kDa cell surface glycoprotein, has been identified as a key receptor for transmitting cellular signals mediating metalloproteinase activities, as well as inflammation and oxidative stress. Clinical evidence has revealed that EMMPRIN is expressed in human atherosclerotic plaque; however, the relationship between EMMPRIN and atherosclerosis is unclear. To evaluate the functional role of EMMPRIN in atherosclerosis, we treated apolipoprotein E-deficient (ApoE(-/-)) mice with an EMMPRIN function-blocking antibody. EMMPRIN was found to be up-regulated in ApoE(-/-) mice fed a 12-week high-fat diet in contrast to 12 weeks of normal diet. Administration of a function-blocking EMMPRIN antibody (100 μg, twice per week for 4 weeks) to ApoE(-/-) mice, starting after 12 weeks of high-fat diet feeding caused attenuated and more stable atherosclerotic lesions, less reactive oxygen stress generation on plaque, as well as down-regulation of circulating interleukin-6 and monocyte chemotactic protein-1 in ApoE(-/-) mice. The benefit of EMMPRIN functional blockage was associated with reduced metalloproteinases proteolytic activity, which delayed the circulating monocyte transmigrating into atherosclerotic lesions. EMMPRIN antibody intervention ameliorated atherosclerosis in ApoE(-/-) mice by the down-regulation of metalloproteinase activity, suggesting that EMMPRIN may be a viable therapeutic target in atherosclerosis. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

REBEKA bundle experiments

International Nuclear Information System (INIS)

Wiehr, K.

1988-05-01

This report is a summary of experimental investigations describing the fuel rod behavior in the refilling and reflooding phase of a loss-of-coolant accident of a PWR. The experiments were performed with 5x5 and 7x7 rod bundles, using indirectly electrically heated fuel rod simulators of full length with original PWR-KWU-geometry, original grid spacers and Zircaloy-4-claddings (Type Biblis B). The fuel rod simulators showed a cosine shaped axial power profile in 7 steps and continuous, respectively. The results describe the influence of the different parameters such as bundle size on the maximum coolant channel blockage, that of the cooling on the size of the circumferential strain of the cladding (azimuthal temperature distribution) a cold control rod guide thimble and the flow direction (axial temperature distribution) on the resulting coolant channel blockage. The rewetting behavior of different fuel rod simulators including ballooned and burst Zircaloy claddings is discussed as well as the influence of thermocouples on the cladding temperature history and the rewetting behavior. All results prove the coolability of a PWR in the case of a LOCA. Therefore, it can be concluded that the ECC-criteria established by licensing authorities can be fulfilled. (orig./HP) [de

Experiment data report for semiscale Mod-1 test S-04-1 (baseline ECC test)

International Nuclear Information System (INIS)

Crapo, H.S.; Collins, B.L.; Sackett, K.E.

1976-09-01

Recorded test data are presented for Test S-04-1 of the Semiscale Mod-1 Baseline ECC Test Series. This test is among several Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor system. Test S-04-1 was conducted from an initial cold leg fluid temperature of 542 0 F and an initial pressure of 2,263 psia. A simulated double-ended offset shear cold leg break was used to investigate the system response to a depressurization and reflood transient using system volume scaled coolant injection parameters. System flow was set to achieve a core fluid temperature differential of 66 0 F at a full core power of 1.6 MW. The flow resistance of the intact loop was based on core area scaling. An electrically heated core with a flat radial power profile was used in the pressure vessel to simulate the effects of a nuclear core. During system depressurization, core power was reduced from the initial level of 1.6 MW in such a manner as to simulate the surface heat flux response of nuclear fuel rods until such time that departure from nucleate boiling might occur. Blowdown to the pressure suppression system was accompanied by simulated emergency core cooling injection into both the intact and broken loops. Coolant injection was continued until test termination at 200 seconds after initiation of blowdown

Estimative of core damage frequency in IPEN's IEA-R1 research reactor (PSA level 1) due to the initiating event of loss of coolant caused by large rupture in the pipe of the primary circuit

International Nuclear Information System (INIS)

Hirata, Daniel Massami

2009-01-01

This work applies the methodology of probabilistic safety assessment level 1 to the research reactor IEA-R1 IPEN-CNEN/SP. Two categories of identified initiating events of accidents in the reactor are studied: loss of flow and loss of primary coolant. Among the initiating events, blockage of flow channel and loss of cooling fluid by major pipe rupture in the primary circuit are chosen for a detailed analysis. The event tree technique is used to analyze the evolution of the accident, including the actuation or the fail of actuation of the safety systems and the reactor damages. Using the fault tree the reliability of the following reactor safety systems is evaluated: reactor shutdown system, isolation of the reactor pool, emergency core cooling system (ECCS) and the electric system. Estimative for the frequency of damage to the reactor core and the probability of failure of the analyzed systems are calculated. The estimated values for the frequencies of core damage are within the expected margins and are of the same order of magnitude as those found for similar reactors. The reliability of the reactor shutdown system, isolation of the reactor pool and ECCS are satisfactory for the conditions these systems are required. However, for the electric system it is suggested an upgrade to increase its reliability. (author)

2D Temperature Analysis of Energy and Exergy Characteristics of Laminar Steady Flow across a Square Cylinder under Strong Blockage

Directory of Open Access Journals (Sweden)

M. Ozgun Korukcu

2015-05-01

Full Text Available Energy and exergy characteristics of a square cylinder (SC in confined flow are investigated computationally by numerically handling the steady-state continuity, Navier-Stokes and energy equations in the Reynolds number range of Re = 10–50, where the blockage ratio (β = B/H is kept constant at the high level of β = 0.8. Computations indicated for the upstream region that, the mean non-dimensional streamwise (u/Uo and spanwise (v/Uo velocities attain the values of u/Uo = 0.840®0.879 and v/Uo = 0.236®0.386 (Re = 10®50 on the front-surface of the SC, implying that Reynolds number and blockage have stronger impact on the spanwise momentum activity. It is determined that flows with high Reynolds number interact with the front-surface of the SC developing thinner thermal boundary layers and greater temperature gradients, which promotes the thermal entropy generation values as well. The strict guidance of the throat, not only resulted in the fully developed flow character, but also imposed additional cooling; such that the analysis pointed out the drop of duct wall (y = 0.025 m non-dimensional temperature values (ζ from ζ = 0.387®0.926 (Re = 10®50 at xth = 0 mm to ζ = 0.002®0.266 at xth = 40 mm. In the downstream region, spanwise thermal disturbances are evaluated to be most inspectable in the vortex driven region, where the temperature values show decrease trends in the spanwise direction. In the corresponding domain, exergy destruction is determined to grow with Reynolds number and decrease in the streamwise direction (xds = 0®10 mm. Besides, asymmetric entropy distributions as well were recorded due to the comprehensive mixing caused by the vortex system.

Equivalence of the blockage of ureter and the action of the urethane in {sup 99m}Tc-DMSA biodistribution in rats

Energy Technology Data Exchange (ETDEWEB)

Martins, Patricia de A.; Fukumori, Neuza T.O.; Matsuda, Margareth M.N.; Vicente, Irene; Silva, Laercio da; Evedove, Sueli D.; Muramoto, Emiko [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mails: patyosborne@yahoo.com; ntfukumo@ipen.br; lsilva@ipen.br; mmatsusa@ipen.br; sevedove@yahoo.com

2007-07-01

The indication of the United States Pharmacopoeia (USP) for biological control of {sup 99m}Tc-DMSA is the experiment in rats with ureter occlusion. Urethane has a vessel constriction action in the urinary system and keeps the eliminatory mechanism functioning through glomerular filtration. The objective of this work is to show that the use of urethane in animals without blockage of ureteres has total credibility, even if the expressed value of the renal retention does not correspond to 40% injected dose (I.D.) related in the literature. The experiments were performed in 2 groups of 12 rats each, the first using urethane and the second, urethane and blockage of ureter. Four lots of DMSA were labeled with 10 mCi/3 mL of {sup 99m}Tc solution, and 300 {mu}Ci/0.1 mL was injected intravenously in each animal. After one hour, they were sacrificed and kidneys, bladder, liver, spleen and carcass were taken out for determination of the retained radiation in function of the injected dose. The USP establishes two parameters for the metabolism of {sup 99m}Tc-DMSA: renal retention equal or higher than 40% and kidneys/liver plus spleen relation equal or higher than 6. In animals whose ureteres were obstructed, it was clearly observed that the urine was not transferred from kidneys to bladder 0.05 {+-} 0.35% I.D., while the first group presented 0.50 {+-} 6.50 % I.D. The kidneys/liver plus spleen relation were above 6 for both. Considering the deviation, all results were in the USP limit of acceptability, and for routine evaluation, urethane can be used without surgical intervention. (author)

Risk-Informed Margin Management (RIMM) Industry Applications IA1 - Integrated Cladding ECCS/LOCA Performance Analysis - Problem Statement

Energy Technology Data Exchange (ETDEWEB)

Szilard, Ronaldo Henriques [Idaho National Lab. (INL), Idaho Falls, ID (United States); Youngblood, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Frepoli, Cesare [Idaho National Lab. (INL), Idaho Falls, ID (United States); Yurko, Joseph P. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Swindlehurst, Gregg [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhang, Hongbin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhao, Haihua [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bayless, Paul D. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Curtis L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2015-04-01

The U. S. NRC is currently proposing rulemaking designated as “10 CFR 50.46c” to revise the LOCA/ECCS acceptance criteria to include the effects of higher burnup on cladding performance as well as to address some other issues. The NRC is also currently resolving the public comments with the final rule expected to be issued in the summer of 2016. The impact of the final 50.46c rule on the industry will involve updating of fuel vendor LOCA evaluation models, NRC review and approval, and licensee submittal of new LOCA evaluations or reanalyses and associated technical specification revisions for NRC review and approval. The rule implementation process, both industry and NRC activities, is expected to take 5-10 years following the rule effective date. The need to use advanced cladding designs is expected. A loss of operational margin will result due to the more restrictive cladding embrittlement criteria. Initial and future compliance with the rule may significantly increase vendor workload and licensee cost as a spectrum of fuel rod initial burnup states may need to be analyzed to demonstrate compliance. Consequently there will be an increased focus on licensee decision making related to LOCA analysis to minimize cost and impact, and to manage margin.

Model for melt blockage (slug) relocation and physico-chemical interactions during core degradation under severe accident conditions

International Nuclear Information System (INIS)

Veshchunov, M.S.; Shestak, V.E.

2008-01-01

The model describing massive melt blockage (slug) relocation and physico-chemical interactions with steam and surrounding fuel rods of a bundle is developed on the base of the observations in the CORA tests. Mass exchange owing to slug oxidation and fuel rods dissolution is described by the previously developed 2D model for the molten pool oxidation. Heat fluxes in oxidising melt along with the oxidation heat effect at the melt relocation front are counterbalanced by the heat losses in the surrounding media and the fusion heat effect of the Zr claddings attacked by the melt. As a result, the slug relocation velocity is calculated from the heat flux matches at the melt propagation front (Stefan problem). A numerical module simulating the slug behaviour is developed by tight coupling of the heat and mass exchange modules. The new model demonstrates a reasonable capability to simulate the main features of the massive slug behaviour observed in the CORA-W1 test

PNA binding to the non-template DNA strand interferes with transcription, suggesting a blockage mechanism mediated by R-loop formation.

Science.gov (United States)

Belotserkovskii, Boris P; Hanawalt, Philip C

2015-11-01

Peptide Nucleic Acids (PNAs) are artificial DNA mimics with superior nucleic acid binding capabilities. T7 RNA polymerase (T7 RNAP) transcription upon encountering PNA bound to the non-template DNA strand was studied in vitro. A characteristic pattern of blockage signals was observed, extending downstream from the PNA binding site, similar to that produced by G-rich homopurine-homopyrimidine (hPu-hPy) sequences and likely caused by R-loop formation. Since blocked transcription complexes in association with stable R-loops may interfere with replication and in some cases trigger apoptosis, targeted R-loop formation might be employed to inactivate selected cells, such as those in tumors, based upon their unique complement of expressed genes. © 2014 The Authors. Molecular Carcinogenesis published by Wiley Periodicals, Inc.

Numerical study of the influence of flow blockage on the aerodynamic coefficients of models in low-speed wind tunnels

Science.gov (United States)

Bui, V. T.; Kalugin, V. T.; Lapygin, V. I.; Khlupnov, A. I.

2017-11-01

With the use of ANSYS Fluent software and ANSYS ICEM CFD calculation grid generator, the flows past a wing airfoil, an infinite cylinder, and 3D blunted bodies located in the open and closed test sections of low-speed wind tunnels were calculated. The mathematical model of the flows included the Reynolds equations and the SST model of turbulence. It was found that the ratios between the aerodynamic coefficients in the test section and in the free (unbounded) stream could be fairly well approximated with a piecewise-linear function of the blockage factor, whose value weakly depended on the angle of attack. The calculated data and data gained in the analysis of previously reported experimental studies proved to be in a good agreement. The impact of the extension of the closed test section on the airfoil lift force is analyzed.

THE AZERBAIJANI OFFICIAL State DISCOURSE ON THE ARMENIANAZERBAIjANI CONFLICT: BLOCKAGES TO PEACE

Directory of Open Access Journals (Sweden)

Lavinia BADULESCU

2018-05-01

Full Text Available The intractable conflict between Armenia and Azerbaijan, the first in a series of inter-ethnic wars to arise in the final years of the Soviet Union, has lasted for three decades and has gone through several violent episodes inflicting widespread death and destruction. Against the background of a long period of tried-and-failed resolution attempts, the conflict has led to the fostering of grievances, prejudice, long-lasting societal trauma and victimhood. Starting from these considerations, this paper seeks to emphasize the way in which, in the official state discourse, the Azerbaijani leaders concentrate mainly on their own traumas and victim status. This type of discourse sets off a unilateral solution to the conflict, considered the only right option, thus preventing any dialogue with the Armenian side, and implicitly any resolution of the conflict. From a methodological perspective, I have selected several official speeches belonging to the Azerbaijani leaders between 1994-2016 and held at various national and international forums. The content analysis of the Azerbaijani official speeches will be complemented by the data collected through semi-structured interviews with Azerbaijani experts in the field of International Relations during a field research to Azerbaijan. The paper concludes that trauma and victimhood as reflected in the official Azerbaijani state discourse function as blockages to peace and hinder any changes in the way Azerbaijani leaders represent the conflict and its resolution.

Experiment data report for semiscale Mod-1 test S-04-2 (baseline ECC test)

International Nuclear Information System (INIS)

Crapo, H.S.; Collins, B.L.; Sackett, K.E.

1976-09-01

Recorded test data are presented for Test S-04-2 of the Semiscale Mod-1 Baseline ECC test series. This test is among Semiscale Mod-1 experiments conducted to investigate the thermal and hydraulic phenomena accompanying a hypothesized loss-of-coolant accident in a pressurized water reactor system. Test S-04-2 was conducted from an initial cold leg fluid temperature of 542 0 F and an initial pressure of 2,263 psia. A simulated double-ended offset shear cold leg break was used to investigate the system response to a depressurization and reflood transient using emergency core coolant injection parameters based on downcomer volume scaling. System flow was set to achieve a core fluid temperature differential of 66 0 F at a full core power of 1.6 MW. The flow resistance of the intact loop was based on core area scaling. An electrically heated core with a flat radial power profile was used in the pressure vessel to simulate the effects of a nuclear core. During system depressurization, core power was reduced from the initial level of 1.6 MW to simulate the surface heat flux response of nuclear fuel rods until such sime that departure from nucleate boiling might occur. Blowdown to the pressure suppression system was accompanied by simulated emergency core coolant injection into both the intact and broken loops. Coolant injection was continued until test termination at 200 seconds after initiation of blowdown. The purpose of the report is to make available the uninterpreted data from Test S-04-2 for future data analysis and test results reporting activities. The data, presented in the form of graphs in engineering units, have been analyzed only to the extent necessary to assure that they are reasonable and consistent

Chemical processes of galvanized steel corrosion in the post-LOCA phase of a PWR and the prevention of sump screen clogging

International Nuclear Information System (INIS)

Hoffmann, W.; Kryk, H.

2012-09-01

The Emergency Core Coolant System has to remove the decay heat in case of a Loss of Coolant Accident (LOCA). Therefore, the emergency core cooling pumps recirculate the fluid from the sump back into the primary circuit. Sump strainers are mounted at the pump inlets to retain particles and fibrous insulation material. A fiber bed formed on strainers may act as an additional debris filter. However, a critical increase of pressure drop generated by debris or corrosion products could cause a failure of emergency cooling. Problems of insulation materials NUKON R (fiberglass) or CalSil and Aluminium may appear if containment spray systems using alkaline additives are installed. In such cases, dissolution / precipitation reactions resulting from insulation materials were observed, which increase the risk of sump screen blockage. In German NPPs, there are no containments spray systems, and insulation consists of more resistant materials like mineral wool (rock wool) and stainless steel. However, large scale experiments from AREVA have shown that sump screen clogging may be initiated by boric acid containing For generic investigations of galvanized steel corrosion behaviour under post-LOCA conditions, the down-scaled test facility KorrVA was designed consisting of a loop with trickle section (location of LOCA), bath section (sump), horizontal strainer and circulation pump. The low coolant volume (60 L) permits an easy and efficient purification between the experiments including complete removal of corrosion products. About 90 experiments were carried out with galvanized steel gratings and galvanized steel coupons in boric acid media in order to determine corrosion mechanisms depending on different experimental conditions like temperature, water chemistry and hydrodynamic conditions (flow impact, simulated by different nozzles). Practically, the fiber bed was prepared during a preliminary stage with the aim to separate effects of fiber bed formation on sump strainer clogging

Avaliação da resistência a fadiga dos Engineered Cementitious Composites (ecc, reforçados com fibra de polipropileno e produzidos com adição de cinza de casca de arroz

Directory of Open Access Journals (Sweden)

Alceu Lopes de Freitas Júnior

2017-07-01

Full Text Available O Engineered Cementitious Composites - ECC – é um tipo especial de compósito cimentício de alto desempenho reforçado com fibra, cuja principal característica é a alta ductilidade. O traço de ECC é composto por cimento, material pozolânico, agregado miúdo e fibras. Este estudo avaliou a resistência à fadiga de traços de Engineered Cementitious Composites reforçados com fibras de polipropileno - PPECC – e cuja composição da matriz cimentícia tenha a incorporação de cinza de casca de arroz como material suplementar. Para isto, foram produzidos corpos de prova com substrato de concreto para pavimento e overlay com o traço de PPECC desenvolvido. Os corpos de prova foram submetidos aos ensaios de flexão a quatro pontos (estático e cíclico. Compararam-se os resultados obtidos no ensaio estático dos traços de PPECC com os resultados obtidos neste mesmo ensaio com corpos de prova produzidos somente por concreto para pavimento. Foram analisados os resultados dos ensaios cíclicos em diferentes intervalos de tensões. Com os resultados variação da tensão x números de ciclos, obtidos no ensaio cíclico, foi avaliado o comportamento à fadiga do compósito.

A photographic portrait of Father Benignus Wanat, discalced Carmelite, with Christ’s head Ecce Homo in the background

Directory of Open Access Journals (Sweden)

Inga Platowska-Sapetowa

2016-12-01

Full Text Available This photographic memory of the late Father Benignus Józef Wanat OCD is based upon a high quality photo, anonymously posted and found accidentally on Facebook on 11 April 2013 after his funeral. Investigations established that the photographer, Jacek Praśkiewicz, is a photographer from Kielce. Additionally, the work includes a descriptive analysis of various aspects of several works of art: a psycho-physical description of the character portrayed its settings and lighting, a description of the ceremonial costume used and its symbolic elements. It has been established that the photo was taken at a celebration of an anniversary held on 12 December 2008. What is crucial to emphasise is this: the relationship of the portrayed person (Fr Benignus Józef Wanat OCD with the portrait’s background, which uses a fragmented image of Christ Ecce Homo, which is of unknown provenance. This latter aspect included a description of the work which is very important, because it shows the supporting facts taken from the biography of Father Benignus, corroborated by the statements of witnesses, of his imitative attitude to Christ, in relation to God-Man suffering in humble silence and bringing aid to his fellow human even to the extent of the sacrifice of his life. [Translatio by Fr E. Wanat SDS

Characterization of primary coolant purification system samples for assay of spent ion exchanger radionuclide inventor

International Nuclear Information System (INIS)

Sajin Prasad, S.; Pant, Amar; Sharma, Ranjit; Pal, Sanjit

2018-01-01

The primary coolant system water of a research reactor contains various fission and activation products and the water is circulated continuously through ion exchange resin cartridges, to reduce the radioactive ionic impurity present in it. The coolant purification system comprises of an ion exchange cooler, two micro filters, and a battery of six ion exchanger beds, associated valves, piping and instrumentation (Heavy water System Operating manual, 2014). The spent cartridge is finally disposed off as active solid waste which contains predominantly long lived fission and activation products. The heavy water coolant is also used to cool the structural assemblies after passing through primary heat exchanger and a metallic strainer, which accumulates the fission and activation products. When there is a reduction of coolant flow through these strainers, they are removed for cleaning and decontamination. This paper describes the characterization of ion exchange resin samples and liquid effluent generated during ultra sonic decontamination of strainer. The results obtained can be used as a methodology for the assay of the spent ion exchanger cartridges radionuclide inventory, during its disposal

R and D program for French sodium fast reactor: On the description and detection of sodium boiling phenomena during sub-assembly blockages

International Nuclear Information System (INIS)

Vanderhaegen, M.; Paumel, K.; Seiler, J. M.; Tourin, A.; Jeannot, J. P.; Rodriguez, G.

2011-01-01

In support of the French ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration) reactor program, which aims to demonstrate the industrial applicability of sodium fast reactors with an increased level of safety demonstration and availability compared to the past French sodium fast reactors, emphasis is placed on reactor instrumentation. It is in this framework that CEA studies continuous core monitoring to detect as early as possible the onset of sodium boiling. Such a detection system is of particular interest due to the rapid progress and the consequences of a Total Instantaneous Blockage (TIB) at a subassembly inlet, where sodium boiling intervenes in an early phase. In this paper, the authors describe all the particularities which intervene during the different boiling stages and explore possibilities for their detection. (authors)

Evaluation of the long duration efficiency of the ECC storage facility of Cogema La Hague plant

International Nuclear Information System (INIS)

Baganz, C.; Bouland, P.; Breton, E.

2004-01-01

The ECC facility of Cogema La Hague has been designed in view of the storage of 24000 CSD-C type containers produced by the ACC facility. It comprises a reception and unloading unit, and a modular storage unit (alveoles). The safety of the facility is based on: a controlled ventilation (low pressurization rooms, controlled atmosphere, heat and toxic gases evacuation), a construction ensuring the static confinement, the sub-criticality and the radiological protection, and the possibility of natural ventilation of the alveoles (earthquake-dimensioned equipments). On the basis of these safety functions, the conformability of the facility with respect to long duration has been analyzed considering three aspects of the facility: the infrastructure, the waste packages and the ventilation system. In normal operation, a foreseeable service life of at least 100 years is established: simpleness and accessibility of ventilation systems, no significant corrosion of packages, durability of the reinforced concrete structure. The demonstration of a service life greater than 100 years would require the improvement of our knowledge about concretes in terms of experience feedback. The behaviour of the facility in terms of loss of technical mastery has been considered too. The scenario retained for this situation is the prolonged stoppage (several months or years) of the nuclear ventilation after a 100 years of disposal. After this period of time, both the thermal power and the hydrogen generation from waste packages will have significantly diminished, allowing a loss of technical mastery era of several years with no impact on concretes integrity. However, during long situations of non-controlled atmosphere, the corrosion behaviour of stainless steels is not predictable. (J.S.)

R&D Plan for RISMC Industry Application #1: ECCS/LOCA Cladding Acceptance Criteria

Energy Technology Data Exchange (ETDEWEB)

Szilard, Ronaldo Henriques [Idaho National Lab. (INL), Idaho Falls, ID (United States); Zhang, Hongbin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Epiney, Aaron Simon [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tu, Lei [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-04-01

The Nuclear Regulatory Commission (NRC) is finalizing a rulemaking change that would revise the requirements in 10 CFR 50.46. In the proposed new rulemaking, designated as 10 CFR 50.46c, the NRC proposes a fuel performance-based equivalent cladding reacted (ECR) criterion as a function of cladding hydrogen content before the accident (pre-transient) in order to include the effects of higher burnup on cladding performance as well as to address other technical issues. A loss of operational margin may result due to the more restrictive cladding embrittlement criteria. Initial and future compliance with the rule may significantly increase vendor workload and licensee costs as a spectrum of fuel rod initial burnup states may need to be analyzed to demonstrate compliance. The Idaho National Laboratory (INL) has initiated a project, as part of the DOE Light Water Reactor Sustainability Program (LWRS), to develop analytical capabilities to support the industry in the transition to the new rule. This project is called the Industry Application 1 (IA1) within the Risk-Informed Safety Margin Characterization (RISMC) Pathway of LWRS. The general idea behind the initiative is the development of an Integrated Evaluation Model (IEM). The motivation is to develop a multiphysics framework to analyze how uncertainties are propagated across the stream of physical disciplines and data involved, as well as how risks are evaluated in a LOCA safety analysis as regulated under 10 CFR 50.46c. This IEM is called LOTUS which stands for LOCA Toolkit for US, and it represents the LWRS Program’s response to the proposed new rule making. The focus of this report is to complete an R&D plan to describe the demonstration of the LOCA/ECCS RISMC Industry Application # 1 using the advanced RISMC Toolkit and methodologies. This report includes the description and development plan for a RISMC LOCA tool that fully couples advanced MOOSE tools already in development in order to characterize and optimize

Blockage of High-Affinity Choline Transporter Increases Visceral Hypersensitivity in Rats with Chronic Stress

Science.gov (United States)

2018-01-01

Background Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1) is of crucial importance in choline uptake system. However, involvement of CHT1 in visceral hypersensitivity remains unknown. The research aimed to study the CHT1 expression in dorsal root ganglions (DRGs) and the role of CHT1 in visceral hypersensitivity. Methods Repetitive water avoidance stress (WAS) was used to induce visceral hypersensitivity in rats. Colorectal distension (CRD) was determined, and the abdominal withdrawal reflex (AWR) and threshold intensity data were recorded to measure the visceral sensitivity. After intraperitoneal injection of hemicholinium-3 (HC-3), the specific inhibitor of CHT1, CRD data were also recorded. The CHT1 expression of DRGs was investigated by Western blotting, immunohistochemistry, and quantitative RT-PCR. Acetylcholine levels in the DRGs were detected by the assay kit. Results Repetitive WAS increased the AWR score of CRD at high distension pressure and decreased the mean threshold of rats. The CHT1 expression and acetylcholine concentration of DRG were significantly increased in WAS rats. After the administration of HC-3, the AWR score in WAS group was significantly increased at higher distension pressure while the threshold intensity was significantly reduced compared to the normal saline group. Acetylcholine concentration was significantly lower than the normal saline rats. Conclusion Our research firstly reports that CHT1 is overexpressed in noninflammatory visceral hypersensitivity, and blockage of CHT1 can enhance the visceral hypersensitivity. CHT1 may play an inhibitory role in visceral hypersensitivity. PMID:29849603

Corrective Action Investigation Plan for Corrective Action Unit 230: Area 22 Sewage Lagoons and Corrective Action Unit 320: Area 22 Desert Rock Airport Strainer Box, Nevada Test Site, Nevada

International Nuclear Information System (INIS)

1999-01-01

This Corrective Action Investigation Plan contains the U.S. Department of Energy, Nevada Operation Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 230/320 under the Federal Facility Agreement and Consent Order. Corrective Action Unit 230 consists of Corrective Action Site (CAS) 22-03-01, Sewage Lagoon; while CAU 320 consists of CAS 22-99-01, Strainer Box. These CAUs are referred to as CAU 230/320 or the Sewage Lagoons Site. The Sewage Lagoons Site also includes an Imhoff tank, sludge bed, and associated buried sewer piping. Located in Area 22, the site was used between 1951 to 1958 for disposal of sanitary sewage effluent from the historic Camp Desert Rock Facility at the Nevada Test Site in Nevada. Based on site history, the contaminants of potential concern include volatile organic compounds (VOCs), semivolatile organic compounds, total petroleum hydrocarbons (TPH), and radionuclides. Vertical migration is estimated to be less than 12 feet below ground surface, and lateral migration is limited to the soil immediately adjacent to or within areas of concern. The proposed investigation will involve a combination of field screening for VOCs and TPH using the direct-push method and excavation using a backhoe to gather soil samples for analysis. Gamma spectroscopy will also be conducted for waste management purposes. Sampling locations will be biased to suspected worst-case areas including the nearby sludge bed, sewage lagoon inlet(s) and outlet(s), disturbed soil surrounding the lagoons, surface drainage channel south of the lagoons, and the area near the Imhoff tank. The results of this field investigation will support a defensible evaluation of corrective action alternatives in the corrective action decision document

Blockage of migration routes by dam construction: can migratory fish find alternative routes?

Directory of Open Access Journals (Sweden)

Rosimeire Ribeiro Antonio

Full Text Available The present study explored the interaction between the upriver migration of fish and the blockage of their migration routes by dam construction. Specifically, we studied (i the capacity of migratory fish to locate alternative routes in the presence of an obstacle, and (ii the behavior of the fish after they were artificially transferred to the reservoir. With the use of the mark-recapture technique (tagging, the study was carried out near Porto Primavera Dam (UHE Engenheiro Sérgio Motta between 1994 and 1999, a period prior to the closure of the floodgates and the installation and operation of the fish pass facilities. The fish were caught in the dam forebay downstream, marked with LEA type tags, and released upstream (5113 individuals; 14 species and downstream (1491; 12 from the dam. The recaptures were carried out by local professional and amateur fishermen. A total of 188 individuals (2.8% were recaptured, mostly the curimba Prochilodus lineatus. Nearly half of the recaptures downstream occurred in tributaries, especially in the Paranapanema River, indicating that in the presence of an obstacle the fish are able to locate alternative migration routes. The remainder stayed in the main channel of the Paraná River, at a mean distance of less than 50 km from the release point. Of the fish released upriver from the dam, approximately half were recaptured downriver. Although the river was only partly dammed, the movement of the fish downriver suggests that they became disoriented after being transferred. Those that remained upriver avoided the reservoir and moved, rather rapidly, toward the lotic stretches farther upstream. From these results it is clear that, in the course of the decision process in installing fish passes, it is necessary to take into account the existence of spawning and nursery areas downriver and upriver from the reservoir.

R and D on early detection of the Total Instantaneous Blockage for 4. Generation Reactors - Inventory of non-nuclear methods investigated by the CEA

International Nuclear Information System (INIS)

Paumel, K.; Jeannot, J.-P.; Vanderhaegen, M.; Massacret, N.; Jeanne, T.; Laffont, G.

2013-06-01

In the safety analysis for the core of the 4. Generation Reactors, the Total Instantaneous Blockage (TIB) is a hypothetic accident scenario involving the melting of the blocked subassembly with a risk of propagation to the neighbouring subassemblies. To avoid this latter consequence a detection system has to scram the reactor. For Superphenix or EFR project a Delayed Neutron Detection Integrated (DND I) was considered as efficient to limit the melting to the first neighbouring subassemblies. Nonetheless for the CFV core the objective of improving the safety leads to limit the melting to the blocked subassembly. For this purpose, the CEA has launched a program development to find a new detection method. This paper provides a brief review of the feedback of R and D, progress and program on the various early non-nuclear detection methods investigated by the CEA: - Temperature measurement at the subassemblies outlet by thermocouples. The advantage of this method is that it will require no additional instrumentation to that already present for continuous monitoring. - Temperature measurement at the subassemblies outlet by Optical Fibers Bragg Grating (OFBG). This technology has the electromagnetic immunity, compactness and short response time. - Temperature measurement at the subassemblies outlet by ultrasound. The measuring point is located closer to the head subassembly and the response time could be shorter. - Acoustic detection of sodium boiling. Boiling occurs early in the accident progress and the area to be monitored may be covered by few sensors. - Subassemblies loss of flow detection by eddy-current flowmeters. This method seems logically the easiest and the most immediate method to detect a blockage. To date, none of these methods has been fully demonstrated to be feasible. It should be noted that temperature measurement methods will probably consist of the detection of a low increase rate using specific signal processing. These methods have been compared

Determining of the Parking Manoeuvre and the Taxi Blockage Adjustment Factor for the Saturation Flow Rate at the Outlet Legs of Signalized Intersections: Case Study from Rasht City (Iran)

Science.gov (United States)

Behbahani, Hamid; Jahangir Samet, Mehdi; Najafi Moghaddam Gilani, Vahid; Amini, Amir

2017-10-01

The presence of taxi stops within the area of signalized intersections at the outlet legs due to unnatural behaviour of the taxis, sudden change of lanes, parking manoeuvres activities and stopping the vehicle to discharge or pick up the passengers have led to reduction of saturation flow rate at the outlet leg of signalized intersections and increased delay as well as affecting the performance of a crossing lane. So far, in term of evaluating effective adjustment factors on saturation flow rate at the inlet legs of the signalized intersections, various studies have been carried out, however; there has not been any studies on effective adjustment factors on saturation flow rate at the inlet legs. Hence, the evaluating of the traffic effects of unique behaviours on the saturation flow rate of the outlet leg is very important. In this research the parking manoeuvre time and taxi blockage time were evaluated and analyzed based on the available lane width as well as determining the effective adjustment factors on the saturation flow rate using recording related data at four signalized intersections in Rasht city. The results show that the average parking manoeuvre time is a function of the lane width and is increased as the lane width is reduced. Also, it is suggested to use the values of 7.37 and 11.31 seconds, respectively for the average parking manoeuvre time and the average blockage time of taxies at the outlet legs of signalized intersections for the traffic designing in Rasht city.

Blockage of High-Affinity Choline Transporter Increases Visceral Hypersensitivity in Rats with Chronic Stress

Directory of Open Access Journals (Sweden)

Chen Zhao

2018-01-01

Full Text Available Background. Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1 is of crucial importance in choline uptake system. However, involvement of CHT1 in visceral hypersensitivity remains unknown. The research aimed to study the CHT1 expression in dorsal root ganglions (DRGs and the role of CHT1 in visceral hypersensitivity. Methods. Repetitive water avoidance stress (WAS was used to induce visceral hypersensitivity in rats. Colorectal distension (CRD was determined, and the abdominal withdrawal reflex (AWR and threshold intensity data were recorded to measure the visceral sensitivity. After intraperitoneal injection of hemicholinium-3 (HC-3, the specific inhibitor of CHT1, CRD data were also recorded. The CHT1 expression of DRGs was investigated by Western blotting, immunohistochemistry, and quantitative RT-PCR. Acetylcholine levels in the DRGs were detected by the assay kit. Results. Repetitive WAS increased the AWR score of CRD at high distension pressure and decreased the mean threshold of rats. The CHT1 expression and acetylcholine concentration of DRG were significantly increased in WAS rats. After the administration of HC-3, the AWR score in WAS group was significantly increased at higher distension pressure while the threshold intensity was significantly reduced compared to the normal saline group. Acetylcholine concentration was significantly lower than the normal saline rats. Conclusion. Our research firstly reports that CHT1 is overexpressed in noninflammatory visceral hypersensitivity, and blockage of CHT1 can enhance the visceral hypersensitivity. CHT1 may play an inhibitory role in visceral hypersensitivity.

Comparison of Candida species isolated from children with and without early childhood caries: A descriptive cross-sectional study

Directory of Open Access Journals (Sweden)

M S Beena

2017-01-01

Full Text Available Background: Early childhood caries (ECC is characterized by the presence of one or more decayed, missing (due to caries, or filled teeth surfaces in any primary tooth, in a child below 6 years of age. Although ECC is primarily associated with high levels of maternal Streptococcus mutans, there has been an increased interest in finding the relationship between oral fungal flora and dental caries. Objective: The aim of the study is to identify and characterize the Candida species and to compare the candidal isolates in children with ECC and without ECC. Materials and Methods: The study was conducted on children below 6 years of age, who were categorized into ECC and non-ECC groups of fifty children each. Samples were collected using sterile cotton swabs and were inoculated on Sabouraud's Dextrose Agar and incubated at 37°C for 24 h. Candidal colonies were isolated, species identified and virulence factors tested for both ECC and non-ECC groups. Results: The candidal carriage among the ECC children was found to be 84%, which was significantly higher than the non-ECC group of 24%. Candida albicans and non-albicans Candida (NAC were isolated in both ECC and non-ECC groups. Phospholipase production was significantly high in ECC group whereas hemolysin production and germ tube formation showed no significant difference between the two groups. Conclusion: A significant correlation was found between the presence of Candida and ECC. NAC also plays an important role in the development of ECC. The virulence factors such as phospholipase may be responsible for the pathogenicity of Candida in the development of ECC.

Pressure vessel fracture studies pertaining to a PWR LOCA-ECC thermal shock: experiments TSE-3 and TSE-4 and update of TSE-1 and TSE-2 analysis

International Nuclear Information System (INIS)

Cheverton, R.D.; Bolt, S.E.

1977-01-01

The LOCA-ECC Thermal Shock Program was established to investigate the potential for flaw propagation in pressurized-water reactor (PWR) vessels during injection of emergency core coolant following a loss-of-coolant accident. Studies thus far have included fracture mechanics analyses of typical PWRs, the design and construction of a thermal shock test facility, determination of material properties for test specimens, and four thermal shock experiments with 0.53-m-OD (21-in.) by 0.15-m-wall (6-in.) cylindrical test specimens. In the first experiment, initiation was not expected and did not occur, although there was a small amount of subcritical crack growth. In the second experiment, initiation of a semicircular flaw took place as expected; the final length along the surface was about four times the initial length, but there was no radial growth. The third and fourth experiments were similar, and the long axial flaw initiated in good agreement with predictions

The repeated-bout effect: influence on biceps brachii oxygenation and myoelectrical activity.

Science.gov (United States)

Muthalib, Makii; Lee, Hoseong; Millet, Guillaume Y; Ferrari, Marco; Nosaka, Kazunori

2011-05-01

This study investigated biceps brachii oxygenation and myoelectrical activity during and following maximal eccentric exercise to better understand the repeated-bout effect. Ten men performed two bouts of eccentric exercise (ECC1, ECC2), consisting of 10 sets of 6 maximal lengthening contractions of the elbow flexors separated by 4 wk. Tissue oxygenation index minimum amplitude (TOI(min)), mean and maximum total hemoglobin volume by near-infrared spectroscopy, torque, and surface electromyography root mean square (EMG(RMS)) during exercise were compared between ECC1 and ECC2. Changes in maximal voluntary isometric contraction (MVC) torque, range of motion, plasma creatine kinase activity, muscle soreness, TOI(min), and EMG(RMS) during sustained (10-s) and 30-repeated isometric contraction tasks at 30% (same absolute force) and 100% MVC (same relative force) for 4 days postexercise were compared between ECC1 and ECC2. No significant differences between ECC1 and ECC2 were evident for changes in torque, TOI(min), mean total hemoglobin volume, maximum total hemoglobin volume, and EMG(RMS) during exercise. Smaller (P < 0.05) changes and faster recovery of muscle damage markers were evident following ECC2 than ECC1. During 30% MVC tasks, TOI(min) did not change, but EMG(RMS) increased 1-4 days following ECC1 and ECC2. During 100% MVC tasks, EMG(RMS) did not change, but torque and TOI(min) decreased 1-4 days following ECC1 and ECC2. TOI(min) during 100% MVC tasks and EMG(RMS) during 30% MVC tasks recovered faster (P < 0.05) following ECC2 than ECC1. We conclude that the repeated-bout effect cannot be explained by altered muscle activation or metabolic/hemodynamic changes, and the faster recovery in muscle oxygenation and activation was mainly due to faster recovery of force.

THE EFFECT OF HERBAL ESSENTIAL OIL IN PRESERVATIVE SOLUTION, ON QUANTITATIVE, VASE LIFE, BACTERIA-INDUCED STEM XYLEM BLOCKAGE OF LISIANTHUS VAR. ECHO

Directory of Open Access Journals (Sweden)

Farzaneh Pourianejad

2014-06-01

Full Text Available In this study the effect of essential oil taken from medicinal plant as antibacterial components in preservative solution of Lisianthus var. Echo (Eustoma grandiflorum was investigated. The test was done with application of preservative solution. Cut flowers were treated with different concentrations of Thyme (Thymus vulgaris, Spearmint (Mentha spicata and Lavender (Lavandula officinalis essential oil in addition to Sucrose 2.5%. The results showed that there was the longest time in vase life with Thyme in 50 ppm (15.6 days and the control treatment showed the shortest vase life (11.6 days. Moreover, Thyme with 50 ppm had the highest effect on relative fresh weight and solution uptake. In addition, bacteria-induced stem xylem blockage, extracted from the end of stem, was cultured in NA medium culture with several concentrations of essential oil. The result showed that in pure concentration (100% inhibition was completed and in various concentrations of essential oil the bacterial population was reduced.

Simulation of a severe accident at a typical PWR due to break of a hot leg ECCS line using MELCOR code

Energy Technology Data Exchange (ETDEWEB)

Lee, Seung Min; Sabundjian, Gaianê, E-mail: smlee@ipen.br, E-mail: gdjian@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2017-11-01

The aim of this work was to simulate a severe accident at a typical PWR caused by break in Emergency Core Cooling System (ECCS) line of a hot leg using the MELCOR code. The nodalization of this typical PWR was elaborated by the Global Research for Safety (GRS) and provided to the CNEN for analysis of the severe accidents at the Angra 2, which is similar to that PWR. Although both of them are not identical the results obtained for that typical PWR may be valuable because of the lack of officially published calculation for Angra 2. Relevant parameters such as pressure, temperature and water level in various control volumes after the break in the hot leg were calculated as well as degree of core degradation and hydrogen concentration in containment. The result obtained in this work could be considered satisfactory in the sense that the physical phenomena reproduced by the simulation were in general very reasonable, and most of the events occurred within acceptable time intervals. However, the uncertainty analysis was not carried out in this work. Furthermore, this scenario could be used as a base for the study of the effectiveness of some preventive or/and mitigating measures of Severe Accident Management (SAMG) by adding associated conditions for each measure in its input. (author)

Simulation of a severe accident at a typical PWR due to break of a hot leg ECCS line using MELCOR code

International Nuclear Information System (INIS)

Lee, Seung Min; Sabundjian, Gaianê

2017-01-01

The aim of this work was to simulate a severe accident at a typical PWR caused by break in Emergency Core Cooling System (ECCS) line of a hot leg using the MELCOR code. The nodalization of this typical PWR was elaborated by the Global Research for Safety (GRS) and provided to the CNEN for analysis of the severe accidents at the Angra 2, which is similar to that PWR. Although both of them are not identical the results obtained for that typical PWR may be valuable because of the lack of officially published calculation for Angra 2. Relevant parameters such as pressure, temperature and water level in various control volumes after the break in the hot leg were calculated as well as degree of core degradation and hydrogen concentration in containment. The result obtained in this work could be considered satisfactory in the sense that the physical phenomena reproduced by the simulation were in general very reasonable, and most of the events occurred within acceptable time intervals. However, the uncertainty analysis was not carried out in this work. Furthermore, this scenario could be used as a base for the study of the effectiveness of some preventive or/and mitigating measures of Severe Accident Management (SAMG) by adding associated conditions for each measure in its input. (author)

Analysis and prevention of water hammer for the emergency core cooling system

International Nuclear Information System (INIS)

Zhao Jun

2008-01-01

Emergency core cooling system (ECCS) is an engineered safety feature of nuclear power plant. If the water hammer happens during ECCS injection, the piping system may be broken. It will cause loss of ECC system and affect the safety of reactor core. Based on the functions and characteristics of ECCS and the theory of water hammer, the paper analyzed the potential risk of water hammer in ECCS in Qinshan III, and proposed modifications to prevent the water-hammer damage during ECCS injection. (authors)

Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation

Directory of Open Access Journals (Sweden)

Y. Denizot

1996-01-01

Full Text Available Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB with extracorporeal circulation (ECC. Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 patients undergoing CPB with ECC. Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 ± 0.7 IU/μg protein and 24th (8.6 ± 0.8 IU/μg protein postoperative hour compared with pre-ECC values (4.9 ± 0.5 IU/μg protein. A deep thrombocytopenia was found during ECC and until the 24th postoperative hour. A drop of leukocyte counts was found during ECC followed by an increase after ECC weaning. While no correlation was found between M-CSF concentrations and the leukocyte counts, M-CSF values were positively correlated with platelet counts only before and during ECC. Thus, M-CSF is not implicated in the thrombocytopenia and the leukopenia generated during CPB with ECC. However the elevated levels of M-CSFa few hours after the end of ECC might play a role in the inflammatory process often observed after CPB.

Thermal-hydraulics analysis of a PWR reactor using zircaloy and carbide silicon reinforced with type S fibers as fuel claddings: Simulation of a channel blockage transient

Energy Technology Data Exchange (ETDEWEB)

Matuck, Vinicius; Ramos, Mario C.; Faria, Rochkhudson B.; Reis, Patricia A.L.; Costa, Antonella L.; Pereira, Claubia, E-mail: rochkdefaria@yahoo.com.br, E-mail: matuck747@gmail.com, E-mail: patricialire@yahoo.com.br, E-mail: marc5663@gmail.com, E-mail: antonella@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte (Brazil). Departamento de Engenharia Nuclear

2017-11-01

A detailed thermal-hydraulic reactor model using as reference data from the Angra 2 Final Safety Analysis Report (FSAR) has been developed and SiC reinforced with Hi-Nicalon type S fibers (SiC HNS) was used as fuel cladding. The goal is to compare its behavior from the thermal viewpoint with the Zircaloy, at the steady- state and transient conditions. The RELAP-3D was used to perform the thermal-hydraulic analysis and a blockage transient has been investigated at full power operation. The transient considered is related to total obstruction of a core cooling channel of one fuel assembly. The calculations were performed using a point kinetic model. The reactor behavior after this transient was analyzed and the time evolution of cladding and coolant temperatures mass flow and void fraction are presented. (author)

Modeling and analysis framework for core damage propagation during flow-blockage-initiated accidents in the Advanced Neutron Source reactor at Oak Ridge National Laboratory

International Nuclear Information System (INIS)

Kim, S.H.; Taleyarkhan, R.P.; Navarro-Valenti, S.; Georgevich, V.

1995-01-01

This paper describes modeling and analysis to evaluate the extent of core damage during flow blockage events in the Advanced Neutron Source (ANS) reactor planned to be built at ORNL. Damage propagation is postulated to occur from thermal conduction between dmaged and undamaged plates due to direct thermal contact. Such direct thermal contact may occur beause of fuel plate swelling during fission product vapor release or plate buckling. Complex phenomena of damage propagation were modeled using a one-dimensional heat transfer model. A parametric study was done for several uncertain variables. The study included investigating effects of plate contact area, convective heat transfer coefficient, thermal conductivity on fuel swelling, and initial temperature of the plate being contacted by the damaged plate. Also, the side support plates were modeled to account for their effects of damage propagation. Results provide useful insights into how variouss uncertain parameters affect damage propagation

Diet and caries-associated bacteria in severe early childhood caries.

Science.gov (United States)

Palmer, C A; Kent, R; Loo, C Y; Hughes, C V; Stutius, E; Pradhan, N; Dahlan, M; Kanasi, E; Arevalo Vasquez, S S; Tanner, A C R

2010-11-01

Frequent consumption of cariogenic foods and bacterial infection are risk factors for early childhood caries (ECC). This study hypothesized that a short diet survey focused on frequency of foods, categorized by putative cariogenicity, would differentiate severe ECC (S-ECC) from caries-free children. Children's diets were obtained by survey and plaque bacteria detected by PCR from 72 S-ECC and 38 caries-free children. S-ECC children had higher scores for between-meal juice (p cariogenicity (p cariogenicity scores. Food frequency, putative cariogenicity, and S. mutans were associated with S-ECC individually and in combination.

Repeated blood flow restriction induces muscle fiber hypertrophy.

Science.gov (United States)

Sudo, Mizuki; Ando, Soichi; Kano, Yutaka

2017-02-01

We recently developed an animal model to investigate the effects of eccentric contraction (ECC) and blood flow restriction (BFR) on muscle tissue at the cellular level. This study clarified the effects of repeated BFR, ECC, and BFR combined with ECC (BFR+ECC) on muscle fiber hypertrophy. Male Wistar rats were assigned to 3 groups: BFR, ECC, and BFR+ECC. The contralateral leg in the BFR group served as a control (CONT). Muscle fiber cross-sectional area (CSA) of the tibialis anterior was determined after the respective treatments for 6 weeks. CSA was greater in the BFR+ECC group than in the CONT (P muscle fiber hypertrophy at the cellular level. Muscle Nerve 55: 274-276, 2017. © 2016 Wiley Periodicals, Inc.

A study on transient heat transfer of the EU-ABWR external core catcher using the phase-change effective convectivity model

International Nuclear Information System (INIS)

Tran Chi Thanh; Nguyen Viet Hung; Tahara, Mika; Kojima, Yoshihiro; Hamazaki, Ryoichi; Kudinov, Pavel

2015-01-01

In advanced designs of Nuclear Power Plants (NPPs), for mitigation of severe accident consequences, on the one hand, the In-Vessel Retention (IVR) concept has been implemented. On the other hand in other new NPP designs (Generation III and III+) with large power reactors, the External Core Catcher (ECC) has been widely adopted. Assessment of ECC design robustness is largely based on analysis of heat transfer of a melt pool formed in the ECC. Transient heat transfer analysis of an ECC is challenging due to (i) uncertainty in the in-vessel accident progression and subsequent vessel failure modes; (ii) long transient, (iii) high Rayleigh number and complex flows involving phase change of the melt pool formed in an ECC. The present paper is concerned with analysis of transient melt pool heat transfer in the ECC of new Advanced Boiling Water Reactor (ABWR) designed by Toshiba Corporation (Japan). According to the ABWR severe accident management strategy, the ECC is initially dry. In order to prevent steam explosion flooding is initiated after termination of melt relocation from the vessel. The ECC full of melt is cooled from the top directly by water and from the bottom through the ECC walls. In order to assess sustainability of the ECC, heat transfer simulation of a stratified melt pool formed in the ECC is carried out. The problem addressed in this work is heat flux distribution at ECC boundaries when cooling is applied (i) from the bottom, (ii) from the top and from the bottom. To perform melt pool heat transfer simulation, we employ Phase-change Effective Convectivity Model (PECM) which was originally developed as a computationally efficient, sufficiently accurate, 2D/3D accident analysis tools for simulation of transient melt pool heat transfer in the reactor lower plenum. Thermal loads from the melt pool to ECC boundaries are determined for selected ex-vessel accident scenarios. Performance of the ECC, efficiency of severe accident management (SAM) measures and

Evaluation of possible associated factors for early childhood caries and severe early childhood caries: a multicenter cross-sectional survey

NARCIS (Netherlands)

Özen, B.; van Strijp, A.J.P.; Özer, L.; Olmus, H.; Genc, A.; Cehreli, S.B.

2016-01-01

Objectives: The present study evaluated associated factors for developing early childhood caries (ECC) and Severe-ECC (S-ECC) in a group of children aged 24–71 months. Potential positive effects of early dental visit on formation of ECC is investigated as well. Study Design: This was a multicenter,

Considerations for Probabilistic Analyses to Assess Potential Changes to Large-Break LOCA Definition for ECCS Requirements

International Nuclear Information System (INIS)

Wilkowski, G.; Rudland, D.; Wolterman, R.; Krishnaswamy, P.; Scott, P.; Rahman, S.; Fairbanks, C.

2002-01-01

The U.S.NRC has undertaken a study to explore changes to the body of Part 50 of the U.S. Federal Code of Regulations, to incorporate risk-informed attributes. One of the regulations selected for this study is 10 CFR 50.46, A cceptance Criteria for Emergency Core Cooling Systems for Light-Water Nuclear Power Reactors . These changes will potentially enhance safety and reduce unnecessary burden on utilities. Specific attention is being paid to redefining the maximum pipe break size for LB-LOCA by determining the spectrum of pipe diameter (or equivalent opening area) versus failure probabilities. In this regard, it is necessary to ensure that all contributors to probabilistic failures are accounted for when redefining ECCS requirements. This paper describes initial efforts being conducted for the U.S.NRC on redefining the LB-LOCA requirements. Consideration of the major contributors to probabilistic failure, and deterministic aspects for modeling them, are being addressed. At this time three major contributors to probabilistic failures are being considered. These include: (1) Analyses of the failure probability from cracking mechanisms that could involve rupture or large opening areas from either through-wall or surface flaws, whether the pipe system was approved for leak-before-break (LBB) or not. (2) Future degradation mechanisms, such as recent occurrence of PWSCC in PWR piping need to be included. This degradation mechanism was not recognized as being an issue when LBB was approved for many plants or when the initial risk-informed inspection plans were developed. (3) Other indirect causes of loss of pressure-boundary integrity than from cracks in the pipe system also should be included. The failure probability from probabilistic fracture mechanics will not account for these other indirect causes that could result in a large opening in the pressure boundary: i.e., failure of bolts on a steam generator manway, flanges, and valves; outside force damage from the

The influence of magnetostatic interactions in exchange-coupled composite particles

DEFF Research Database (Denmark)

Vokoun, D.; Beleggia, Marco; De Graef, M.

2010-01-01

Exchange-coupled composite (ECC) particles are the basic constituents of ECC magnetic recording media. We examine and compare two types of ECC particles: (i) core-shell structures, consisting of a hard-magnetic core and a coaxial soft-magnetic shell and (ii) conventional ECC particles, with a hard-magnetic...... core topped by a soft cylindrical element. The model we present describes the magnetic response of the two ECC particle types, taking into account all significant magnetic contributions to the energy landscape. Special emphasis is given to the magnetostatic (dipolar) interaction energy. We find...... that both the switching fields and the zero-field energy barrier depend strongly on the particle geometry. A comparison between the two types reveals that core-shell ECC particles are more effective in switching field reduction, while conventional ECC particles maintain a larger overall figure of merit....

Positive detection of exfoliated colon cancer cells on linear stapler cartridges was associated with depth of tumor invasion and preoperative bowel preparation in colon cancer.

Science.gov (United States)

Ikehara, Kishiko; Endo, Shungo; Kumamoto, Kensuke; Hidaka, Eiji; Ishida, Fumio; Tanaka, Jun-Ichi; Kudo, Shin-Ei

2016-08-31

The aim of this study was to investigate exfoliated cancer cells (ECCs) on linear stapler cartridges used for anastomotic sites in colon cancer. We prospectively analyzed ECCs on linear stapler cartridges used for anastomosis in 100 colon cancer patients who underwent colectomy. Having completed the functional end-to-end anastomosis, the linear stapler cartridges were irrigated with saline, which was collected for cytological examination and cytological diagnoses were made by board-certified pathologists based on Papanicolaou staining. The detection rate of ECCs on the linear stapler cartridges was 20 %. Positive detection of ECCs was significantly associated with depth of tumor invasion (p = 0.012) and preoperative bowel preparation (p = 0.003). There were no marked differences between ECC-positive and ECC-negative groups in terms of the operation methods, tumor location, histopathological classification, and surgical margins. Since ECCs were identified on the cartridge of the linear stapler used for anastomosis, preoperative mechanical bowel preparation using polyethylene glycol solution and cleansing at anastomotic sites using tumoricidal agents before anastomosis may be necessary to decrease ECCs in advanced colon cancer.

Assessing the thermal-hydraulic behaviour of steam generators in a CANDU-6 type NPP in the event of MSSV blockage on the open-setting

International Nuclear Information System (INIS)

Dinca, Elena

2004-01-01

This work aims at achieving an analysis regarding the thermal-hydraulic behaviour of a CANDU-6 type NPP in the event of the blockage on open-setting of an MSSV (Main Steam Safety Valve) for steam relief from steam generators. The systems studied are main steam and feedwater mixture in the secondary circuit, particularly being analyzed the behaviour of the steam generators as well as the primary heat transfer and the control system of heavy water pressure and inventory in the primary system. One supposes that the MSSV blockage occurs directly after its opening in the event of an accident that led to the a steam pressure rise in the steam generators up to the threshold value of MSSV o penning. The analysis was applied to two events of initiation which lead to MSSV o penning, namely a Class IV loss of electric supply and loss of vacuum in turbine condenser. In the simulation of the events selected for analysis a long elapse of time is supposed (3600 seconds) and no operator intervention while the NPP is operating at rating power and equilibrium fuel regime. Each of the two events were analyzed for two distinct sets of conditions of event initiation and evolution. The study was focussed on the behaviour of NPP, particularly of the steam generators, and on the estimation of the amount of water in the secondary circuit released into the atmosphere during the event. The analysis is of deterministic type and supplies information required by the Probabilistic Safety Assessment (PSA) applied to nuclear facilities in establishing the operation procedures and documentation. The analysis was based on design data for a CANDU-6 NPP and the HYDN3 code for thermal-hydraulic computation in CANDU type NPPs. In the paper there are presented the analysis, methodology, models, hypotheses and the input data as well as the analyzed cases. Within the computing code some models were developed to allow simulating the event sequences chosen for analyses. The results are plotted and

Shear crack formation and propagation in reinforced Engineered Cementitious Composites

DEFF Research Database (Denmark)

Paegle, Ieva; Fischer, Gregor

2011-01-01

capacity of beams loaded primarily in shear. The experimental program consists of ECC with short randomly distributed polyvinyl alcohol (PVA) fiber beams with different stirrup arrangements and conventional reinforced concrete (R/C) counterparts for comparison. The shear crack formation mechanism of ECC......This paper describes an experimental investigation of the shear behaviour of beams consisting of steel reinforced Engineered Cementitious Composites (R/ECC). Based on the strain hardening and multiple cracking behaviour of ECC, this study investigates the extent to which ECC influences the shear...

Prevalence and Data Availability of Early Childhood Caries in 193 United Nations Countries, 2007-2017.

Science.gov (United States)

El Tantawi, Maha; Folayan, Morenike O; Mehaina, Mohamed; Vukovic, Ana; Castillo, Jorge L; Gaffar, Balgis O; Arheiam, Arheiam; Al-Batayneh, Ola B; Kemoli, Arthur M; Schroth, Robert J; Lee, Gillian H M

2018-06-21

To assess the relationship between health care system and economic factors and early childhood caries (ECC) data availability and prevalence. We estimated ECC data for 193 United Nations countries from studies published between 2007 and 2017. We obtained other variables from the World Health Organization and the World Bank databases. We assessed association with ECC data availability by using logistic regression and with ECC prevalence by using linear regression. We included 190 publications from 88 (45.6%) countries. The mean ECC prevalence was 23.8% and 57.3% in children younger than 36 months and children aged 36 to 71 months, respectively. The odds of ECC data availability were significantly higher for countries with more physicians and more dentists. In children younger than 36 months, ECC prevalence was associated with universal health coverage (B = -6.56). In children aged 36 to 71 months, it was associated with growth of gross national income (B = 0.27). Countries with more physicians and more dentists were more likely to have ECC data. Among those with data, countries with higher economic growth had higher ECC prevalence. (Am J Public Health. Published online ahead of print June 21, 2018: e1-e7. doi:10.2105/AJPH.2018.304466).

The effects of a repeated bout of eccentric exercise on indices of muscle damage and delayed onset muscle soreness.

Science.gov (United States)

Paddon-Jones, D; Muthalib, M; Jenkins, D

2000-03-01

This study examined markers of muscle damage following a repeated bout of maximal isokinetic eccentric exercise performed prior to full recovery from a previous bout. Twenty non-resistance trained volunteers were randomly assigned to a control (CON, n=10) or experimental (EXP, n=10) group. Both groups performed 36 maximal isokinetic eccentric contractions of the elbow flexors of the non-dominant arm (ECC1). The EXP group repeated the same eccentric exercise bout two days later (ECC2). Total work and peak eccentric torque were recorded during each set of ECC1 and ECC2. Isometric torque, delayed onset muscle soreness (DOMS), flexed elbow angle and plasma creatine kinase (CK) activity were measured prior to and immediately following ECC1 and ECC2. at 24h intervals for 7 days following ECC1 and finally on day 11. In both groups, all dependent variables changed significantly during the 2 days following ECC1. A further acute post-exercise impairment in isometric torque (30 +/- 5%) and flexed elbow angle (20 +/- 4%) was observed following ECC2 (p0.05). These findings suggest that when maximal isokinetic eccentric exercise is repeated two days after experiencing of contraction-induced muscle damage, the recovery time course is not significantly altered.

A novel minimal invasive mouse model of extracorporeal circulation.

Science.gov (United States)

Luo, Shuhua; Tang, Menglin; Du, Lei; Gong, Lina; Xu, Jin; Chen, Youwen; Wang, Yabo; Lin, Ke; An, Qi

2015-01-01

Extracorporeal circulation (ECC) is necessary for conventional cardiac surgery and life support, but it often triggers systemic inflammation that can significantly damage tissue. Studies of ECC have been limited to large animals because of the complexity of the surgical procedures involved, which has hampered detailed understanding of ECC-induced injury. Here we describe a minimally invasive mouse model of ECC that may allow more extensive mechanistic studies. The right carotid artery and external jugular vein of anesthetized adult male C57BL/6 mice were cannulated to allow blood flow through a 1/32-inch external tube. All animals (n = 20) survived 30 min ECC and subsequent 60 min observation. Blood analysis after ECC showed significant increases in levels of tumor necrosis factor α, interleukin-6, and neutrophil elastase in plasma, lung, and renal tissues, as well as increases in plasma creatinine and cystatin C and decreases in the oxygenation index. Histopathology showed that ECC induced the expected lung inflammation, which included alveolar congestion, hemorrhage, neutrophil infiltration, and alveolar wall thickening; in renal tissue, ECC induced intracytoplasmic vacuolization, acute tubular necrosis, and epithelial swelling. Our results suggest that this novel, minimally invasive mouse model can recapitulate many of the clinical features of ECC-induced systemic inflammatory response and organ injury.

A Novel Minimal Invasive Mouse Model of Extracorporeal Circulation

Directory of Open Access Journals (Sweden)

Shuhua Luo

2015-01-01

Full Text Available Extracorporeal circulation (ECC is necessary for conventional cardiac surgery and life support, but it often triggers systemic inflammation that can significantly damage tissue. Studies of ECC have been limited to large animals because of the complexity of the surgical procedures involved, which has hampered detailed understanding of ECC-induced injury. Here we describe a minimally invasive mouse model of ECC that may allow more extensive mechanistic studies. The right carotid artery and external jugular vein of anesthetized adult male C57BL/6 mice were cannulated to allow blood flow through a 1/32-inch external tube. All animals (n=20 survived 30 min ECC and subsequent 60 min observation. Blood analysis after ECC showed significant increases in levels of tumor necrosis factor α, interleukin-6, and neutrophil elastase in plasma, lung, and renal tissues, as well as increases in plasma creatinine and cystatin C and decreases in the oxygenation index. Histopathology showed that ECC induced the expected lung inflammation, which included alveolar congestion, hemorrhage, neutrophil infiltration, and alveolar wall thickening; in renal tissue, ECC induced intracytoplasmic vacuolization, acute tubular necrosis, and epithelial swelling. Our results suggest that this novel, minimally invasive mouse model can recapitulate many of the clinical features of ECC-induced systemic inflammatory response and organ injury.

Human or monitor feedback to improve mask ventilation during simulated neonatal cardiopulmonary resuscitation.

Science.gov (United States)

Binder, Corinna; Schmölzer, Georg M; O'Reilly, Megan; Schwaberger, Bernhard; Urlesberger, Berndt; Pichler, Gerhard

2014-03-01

To investigate if external chest compressions (ECC) increase mask leak, and if human or technical feedback improves mask ventilation during simulated neonatal cardiopulmonary resuscitation (CPR). In this observational study, 32 participants delivered positive pressure ventilation (PPV) to a modified, leak-free manikin via facemask. Mask leak, tidal volume (VT), positive end expiratory pressure (PEEP) and respiratory rate (RR) were measured with a respiratory function monitor (RFM). Participants had to perform four studies. In the first study, participants performed PPV alone as baseline. Thereafter, three studies were performed in random order. In the PPV+ECC+manometer group, participants had to observe the manometer while the RFM was covered; in the PPV+ECC+RFM group, the RFM was used while the manometer was covered; and in the PPV+ECC+verbal feedback group, the RFM and manometer were covered while a team leader viewed the RFM and provided verbal feedback to the participants. Median (IQR) mask leak of all studies was 15% (5-47%). Comparing the studies, PPV+ECC+RFM and PPV+ECC+verbal feedback had significantly less mask leak than PPV+ECC+manometer. Mean (SD) VT of all studies was 9.5±3.5 mL. Comparing all studies, PPV+ECC+RFM had a significantly higher VT than PPV and PPV+ECC+manometer. As well, PPV+ECC+verbal feedback had a significantly higher VT than PPV. PEEP and RR were within our target, mean (SD) PEEP was 6±2 cmH2O and RR was 36±13/min. During simulated neonatal CPR, ECCs did not influence mask leak, and a RFM and verbal feedback were helpful methods to reduce mask leak and increase VT significantly.

Phosphate, urea and creatinine clearances: haemodialysis adequacy assessed by weekly monitoring.

Science.gov (United States)

Debowska, Malgorzata; Wojcik-Zaluska, Alicja; Ksiazek, Andrzej; Zaluska, Wojciech; Waniewski, Jacek

2015-01-01

The specific distribution of phosphate and the control mechanisms for its plasma level makes phosphate kinetics during haemodialysis (HD) considerably different from those of urea and creatinine and makes the quantitative evaluation of adequacy of phosphate removal difficult. We propose the application of equivalent continuous clearance (ECC) as a phosphate adequacy parameter and compare it with ECC for creatinine and urea. Three consecutive dialysis sessions were evaluated for 25 patients on maintenance HD. Concentrations of phosphate, urea and creatinine in plasma were measured every 1h during the treatment and 45 min after, and every 30 min in dialysate. ECC was calculated using the removed solute mass assessed in dialysate and weekly solute profile in plasma. Similar calculations were performed also for the midweek dialysis session only. Different versions of the reference concentration for ECC were applied. ECC with peak average reference concentration was 5.4 ± 1.0 for phosphate, 7.0 ± 1.0 for urea and 4.7 ± 1.0 mL/min for creatinine. ECC for urea and creatinine were well correlated in contrast to the correlations of ECC for phosphate versus urea and creatinine. Midweek ECC were higher than weekly ECC, but they were well correlated for urea and creatinine, but only weakly for phosphate. HD adequacy monitoring for phosphate may be performed using ECC, but it is less predictable than similar indices for urea and creatinine. The values of ECC for phosphate are within the range expected for its molecular size compared with those for urea and creatinine. © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

The effect of differing support surfaces on the efficacy of chest compressions using a resuscitation manikin model.

Science.gov (United States)

Tweed, M; Tweed, C; Perkins, G D

2001-11-01

External chest compression (ECC) efficacy is influenced by factors including the surface supporting the patient. Air-filled support surfaces are deflated for cardiopulmonary resuscitation, with little evidence to substantiate this. We investigated the effect that differing support surfaces had on ECC efficacy using a CPR manikin model. Four participants carried out four cycles of ECC with an assistant ventilating. The subjects were blinded to the seven support surfaces and the order was randomised. For each participant/surface combination, ECC variables and the participants' perceptions were measured. Participants produced effective ECC with the manikin on the floor (mean proportion correct, 94.5%; mean depth, 42.5 mm). Compared with the floor: the proportion of correct ECC was less for the overlay inflated (PCPR.

Experimental study of pressure drops through LOCA-generated debris deposited on a fuel assembly

Energy Technology Data Exchange (ETDEWEB)

Suh, Jeong Kwan, E-mail: jksuh@khnp.co.kr [KHNP Central Research Institute, 1312-70 Yuseong-daero, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Kim, Jae Won; Kwon, Sun Guk; Lee, Jae Yong [KHNP Central Research Institute, 1312-70 Yuseong-daero, Yuseong-gu, Daejeon 305-343 (Korea, Republic of); Cho, Hyoung Kyu; Park, Goon Cherl [Department of Nuclear Engineering, Seoul National University, Seoul 151-742 (Korea, Republic of)

2015-08-15

Highlights: • In-vessel downstream effect tests were performed in the presence of LOCA-generated debris. • Available driving heads under each LOCA scenario were verified using experimental data. • Fibrous debris was prepared to satisfy the length distribution obtained from the bypass test. • Limiting test conditions were identified through sensitivity studies. - Abstract: Under post loss-of-coolant accident (LOCA) conditions, it is postulated that debris can be generated and transported to the containment sump strainer. Some of the debris may pass through the strainer and could challenge the long-term core cooling capability of the plant. To address this safety issue, in-vessel downstream effect tests for the advanced power reactor (APR) 1400 were performed. Fibrous debris is the most crucial material in terms of causing pressure drops, and was prepared in this study to satisfy the fiber length distribution obtained through a strainer bypass test. Sensitivity studies on pressure drops through LOCA-generated debris deposited on a fuel assembly were performed to evaluate the effects of water chemistry and fiber length distribution. The pressure drops with debris laden pure water were substantially less than those with debris laden ordinary tap water. The experiment with fiber length distribution suggested by WCAP-16793 showed lower pressure drops than those with the APR1400 specific fiber length distribution. All the experimental results showed that the pressure drops in the mock-up fuel assembly were less than the available driving head at each LOCA scenario.

Development of selective medium for IMP-type carbapenemase-producing Enterobacteriaceae in stool specimens.

Science.gov (United States)

Yamamoto, Norihisa; Kawahara, Ryuji; Akeda, Yukihiro; Shanmugakani, Rathina Kumar; Yoshida, Hisao; Hagiya, Hideharu; Hara, Naohiro; Nishi, Isao; Yukawa, Satomi; Asada, Rumiko; Sasaki, Yumi; Maeda, Kazuhiro; Sakamoto, Noriko; Hamada, Shigeyuki; Tomono, Kazunori

2017-03-24

Identification of carbapenemase-producing Enterobacteriaceae (CPE) in faecal specimens is challenging. This fact is particularly critical because low-level carbapenem-resistant organisms such as IMP-producing CPE are most prevalent in Japan. We developed a modified selective medium more suitable for IMP-type CPE. Fifteen reference CPE strains producing different types of β-lactamases were used to evaluate the commercially available CHROMagar KPC and chromID CARBA as well as the newly prepared MC-ECC medium (CHROMagar ECC supplemented with meropenem, cloxacillin, and ZnSO 4 ) and M-ECC medium (CHROMagar ECC supplemented with meropenem and ZnSO 4 ). A total of 1035 clinical samples were then examined to detect CPE using chromID CARBA and M-ECC medium. All tested strains producing NDM-, KPC-, and OXA-48-carbapenemases were successfully cultured in the media employed. Although most of the IMP-positive strains did not grow in CHROMagar KPC, chromID CARBA, or MC-ECC, all tested strains grew on M-ECC. When faecal samples were applied to the media, M-ECC medium allowed the best growth of IMP-type CPE with a significantly higher sensitivity (99.3%) than that of chromID CARBA (13.9%). M-ECC medium was determined as the most favourable selective medium for the detection of IMP-type CPE as well as other types of CPE.

Effects of Streptomycin Administration on Increases in Skeletal Muscle Fiber Permeability and Size Following Eccentric Muscle Contractions.

Science.gov (United States)

Hayao, Keishi; Tamaki, Hiroyuki; Nakagawa, Kouki; Tamakoshi, Keigo; Takahashi, Hideaki; Yotani, Kengo; Ogita, Futoshi; Yamamoto, Noriaki; Onishi, Hideaki

2018-06-01

The purpose of this study was to investigate the preventive effect of streptomycin (Str) administration on changes in membrane permeability and the histomorphological characteristics of damaged muscle fibers following eccentric contraction (ECC ). Eighteen 7-week-old male Fischer 344 rats were randomly assigned to three groups: control (Cont), ECC, and ECC with Str (ECC + Str). The tibialis anterior (TA) muscles in both ECC groups were stimulated electrically and exhibited ECC. Evans blue dye (EBD), a marker of muscle fiber damage associated with increased membrane permeability, was injected 24 hr before TA muscle sampling. The number of EBD-positive fibers, muscle fiber cross-sectional area (CSA), and roundness were determined via histomorphological analysis. The ECC intervention resulted in an increased fraction of EBD-positive fibers, a larger CSA, and decreased roundness. The fraction of EBD-positive fibers was 79% lower in the ECC + Str group than in the ECC group. However, there was no difference in the CSA and roundness of the EBD-positive fibers between the two ECC groups. These results suggest that Str administration can reduce the number of myofibers that increase membrane permeability following ECC, but does not ameliorate the extent of fiber swelling in extant EBD-positive fibers. Anat Rec, 301:1096-1102, 2018. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.

Resource Utilization Associated with Extracardiac Co-morbid Conditions Following Congenital Heart Surgery in Infancy.

Science.gov (United States)

Tuomela, Krista E; Gordon, John B; Cassidy, Laura D; Johaningsmeir, Sarah; Ghanayem, Nancy S

2017-06-01

Congenital heart disease (CHD) is often associated with chronic extracardiac co-morbid conditions (ECC). The presence of ECC has been associated with greater resource utilization during the operative period; however, the impact beyond hospital discharge has not been described. This study sought to understand the scope of chronic ECC in infants with CHD as well as to describe the impact of ECC on resource utilization after discharge from the index cardiac procedure. IRB approved this retrospective study of infants Whitney Rank Sum Test with p < 0.05 considered significant. ECC occurred in 55% (481/876) of infants. Median STAT score was higher in the group with ECC (3 vs. 2, p < 0.001). Resource utilization after discharge from the index procedure as defined by median hospital charges (78 vs. 10 K, p < 0.001 and unplanned hospital days 4 vs. 0, p < 0.001) was higher in those with ECC, and increased with the greater number of ECC, even after accounting for surgical complexity. STAT score and the presence of multiple ECC were associated with higher resource utilization following the index cardiac surgical procedure. These data may be helpful in deciding which children might benefit from a cardiac complex care program that partners families and providers to improve health and decrease healthcare costs.

the use of integrated soil fertility approach in the improvement of soil

African Journals Online (AJOL)

Sammy

improvement of soil texture and structure, thus boosters food production in the ecological region. ... the farm (Strainer 1984, Nicholaida et al 1985, Juo 1987, Renand et al 1997, ... degraded each year, due principally to water and wind erosion.

Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood.

Science.gov (United States)

Colombo, Natália Helena; Pereira, Jesse Augusto; da Silva, Márjully Eduardo Rodrigues; Ribas, Laís Fernanda Fonseca; Parisotto, Thaís Manzano; Mattos-Graner, Renata de Oliveira; Smith, Daniel J; Duque, Cristiane

2016-07-01

Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. 36-60 month-old children were grouped into Caries-Free (CF, n=19), Early Childhood Caries (ECC, n=17) and Severe Early Childhood Caries (S-ECC, n=21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. Copyright © 2016 Elsevier Ltd. All rights reserved.

Combined deficiencies of 25-hydroxyvitamin D and anemia in preschool children with severe early childhood caries: A case-control study.

Science.gov (United States)

Deane, Shannon; Schroth, Robert J; Sharma, Atul; Rodd, Celia

2018-05-01

Severe early childhood caries (S-ECC) is common and has adverse affects on children's health. Children with S-ECC have been shown to have anemia or vitamin D deficiency. No studies have assessed the presence of combined deficiencies with S-ECC. The purpose of our study was to examine whether those with S-ECC had a higher prevalence of combined anemia and low 25-hydroxyvitamin D (25(OH)D) compared to controls. Covariates associated with elevated parathyroid hormone (PTH), previously noted in S-ECC, were examined. This is a re-analyses of a previously described cross-sectional case-control study; data were collected between 2009 and 2011. Children with S-ECC were recruited on the day of dental surgery and controls from the community. Blood was drawn for complete blood count, ferritin, 25(OH)D and PTH. Families completed a questionnaire. A total of 266 children participated (S-ECC n=144); the mean age was 40.8 ± 14.1 months. Children with S-ECC were more likely to have low 25(OH)D, hemoglobin, elevated PTH or iron-deficiency anemia compared to controls. Significant differences between groups were seen for a combined deficiency of low hemoglobin (<110 g/L) and 25(OH)D < 50 nmol/L; controls 0/114 versus S-ECC 15/140 (P<0.001). In an adjusted regression model, PTH was negatively associated with 25(OH)D (P<0.001) and higher income (P<0.02); it was positively associated with less regular milk consumption (P=0.001). Combined deficiencies of vitamin D and anemia are more prevalent in children with S-ECC; the etiology remains unclear. A detailed diet history is key in those with S-ECC to assess risks for deficiencies.

Comparison between maximal lengthening and shortening contractions for biceps brachii muscle oxygenation and hemodynamics.

Science.gov (United States)

Muthalib, Makii; Lee, Hoseong; Millet, Guillaume Y; Ferrari, Marco; Nosaka, Kazunori

2010-09-01

Eccentric contractions (ECC) require lower systemic oxygen (O2) and induce greater symptoms of muscle damage than concentric contractions (CON); however, it is not known if local muscle oxygenation is lower in ECC than CON during and following exercise. This study compared between ECC and CON for changes in biceps brachii muscle oxygenation [tissue oxygenation index (TOI)] and hemodynamics [total hemoglobin volume (tHb)=oxygenated-Hb+deoxygenated-Hb], determined by near-infrared spectroscopy over 10 sets of 6 maximal contractions of the elbow flexors of 10 healthy subjects. This study also compared between ECC and CON for changes in TOI and tHb during a 10-s sustained and 30-repeated maximal isometric contraction (MVC) task measured immediately before and after and 1-3 days following exercise. The torque integral during ECC was greater (P<0.05) than that during CON by approximately 30%, and the decrease in TOI was smaller (P<0.05) by approximately 50% during ECC than CON. Increases in tHb during the relaxation phases were smaller (P<0.05) by approximately 100% for ECC than CON; however, the decreases in tHb during the contraction phases were not significantly different between sessions. These results suggest that ECC utilizes a lower muscle O2 relative to O2 supply compared with CON. Following exercise, greater (P<0.05) decreases in MVC strength and increases in plasma creatine kinase activity and muscle soreness were evident 1-3 days after ECC than CON. Torque integral, TOI, and tHb during the sustained and repeated MVC tasks decreased (P<0.01) only after ECC, suggesting that muscle O2 demand relative to O2 supply during the isometric tasks was decreased after ECC. This could mainly be due to a lower maximal muscle mass activated as a consequence of muscle damage; however, an increase in O2 supply due to microcirculation dysfunction and/or inflammatory vasodilatory responses after ECC is recognized.

Modeling and analysis framework for core damage propagation during flow-blockage-initiated accidents in the advanced neutron source reactor at Oak Ridge National Laboratory

Energy Technology Data Exchange (ETDEWEB)

Kim, S.H.; Taleyarkhan, R.P.; Navarro-Valenti, S.; Georgevich, V. [Oak Ridge National Lab., TN (United States)

1995-09-01

This paper describes modeling and analysis to evaluate the extent of core damage during flow blockage events in the Advanced Neutron Source (ANS) reactor planned to be built at the Oak Ridge National Laboratory (ORNL). Damage propagation is postulated to occur from thermal conduction between damaged and undamaged plates due to direct thermal contact. Such direct thermal contact may occur because of fuel plate swelling during fission product vapor release or plate buckling. Complex phenomena of damage propagation were modeled using a one-dimensional heat transfer model. A scoping study was conducted to learn what parameters are important for core damage propagation, and to obtain initial estimates of core melt mass for addressing recriticality and steam explosion events. The study included investigating the effect of the plate contact area, the convective heat transfer coefficient, thermal conductivity upon fuel swelling, and the initial temperature of the plate being contacted by the damaged plate. Also, the side support plates were modeled to account for their effects on damage propagation. The results provide useful insights into how various uncertain parameters affect damage propagation.

Identification of Caries Risk Determinants in Toddlers: Results of the GUSTO Birth Cohort Study.

Science.gov (United States)

Un Lam, C; Khin, L W; Kalhan, A C; Yee, R; Lee, Y S; Chong, M F-F; Kwek, K; Saw, S M; Godfrey, K; Chong, Y S; Hsu, C-Y

2017-01-01

The aim of this study was to identify risk determinants leading to early childhood caries (ECC) and visible plaque (VP) in toddlers. Data for mother-child pairs participating in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort were collected from pregnancy to toddlerhood. Oral examinations were performed in 543 children during their clinic visit at 24 months to detect ECC and VP. Following logistic regression, ECC and VP were jointly regressed as primary and secondary outcomes, respectively, using the bivariate probit model. The ECC prevalence was 17.8% at 2 years of age, with 7.3% of children having a VP score >1. ECC was associated with nighttime breastfeeding (3 weeks) and biological factors, including Indian ethnicity (lower ECC rate), higher maternal childbearing age and existing health conditions, maternal plasma folate brushing frequency, lower parental perceived importance of baby teeth, and weaning onto solids. Interestingly, although a higher frequency of dental visits and toothbrushing were associated with lower plaque accumulation, they were associated with increased ECC risk, suggesting that these established caries-risk factors may be a consequence rather than the cause of ECC. In conclusion, Indian toddlers may be less susceptible to ECC, compared to Chinese and Malay toddlers. The study also highlights a problem-driven utilization pattern of dental services (care sought for treatment) in Singapore, in contrast to the prevention-driven approach (care sought to prevent disease) in Western countries. © 2017 S. Karger AG, Basel.

Interactive Real-time Simulation of a Nuclear Reactor Emergency Core Cooling System on a Desktop Computer

International Nuclear Information System (INIS)

Muncharoen, C.; Chanyotha, S.; Bereznai, G.

1998-01-01

The simulation of the Emergency Core Cooling System for a 900 MW nuclear power plant has been developed by using object oriented programming language. It is capable of generating code that executes in real-time on a PENTIUM 100 or equivalent personal computer. Graphical user interface ECCS screens have been developed using Lab VIEW to allow interactive control of ECCS. The usual simulator functions, such as freeze, run, iterate, have been provided, and a number of malfunctions may be activated. A large pipe break near the reactor inlet header has been simulated to verify the response of the ECCS model. LOCA detection, ECC initiation, injection and recovery phased are all modeled, and give results consistent with safety analysis data for a 100% break. With stand alone ECCS simulation, the changes of flow and pressure in ECCS can be observed. The operator can study operational procedures and get used to LOCA in case of the LOCA. Practicing with malfunction, the operator will improve problem solving skills and gain a deeper comprehension of ECCS

Implementation of Pollard Rho attack on elliptic curve cryptography over binary fields

Science.gov (United States)

Wienardo, Yuliawan, Fajar; Muchtadi-Alamsyah, Intan; Rahardjo, Budi

2015-09-01

Elliptic Curve Cryptography (ECC) is a public key cryptosystem with a security level determined by discrete logarithm problem called Elliptic Curve Discrete Logarithm Problem (ECDLP). John M. Pollard proposed an algorithm for discrete logarithm problem based on Monte Carlo method and known as Pollard Rho algorithm. The best current brute-force attack for ECC is Pollard Rho algorithm. In this research we implement modified Pollard Rho algorithm on ECC over GF (241). As the result, the runtime of Pollard Rho algorithm increases exponentially with the increase of the ECC key length. This work also presents the estimated runtime of Pollard Rho attack on ECC over longer bits.

Simulation of a large break loss of coolant (LBLOCA), without actuation of the emergency injection systems (ECCS) for a BWR-5; Simulacion de un escenario de perdida de refrigerante grande (LBLOCA), sin actuacion de los sistemas de inyeccion de emergencia (ECCS) para un reactor BWR-5

Energy Technology Data Exchange (ETDEWEB)

Cardenas V, J.; Mugica R, C. A.; Lopez M, R., E-mail: jaime.cardenas@cnsns.gob.mx [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Barragan 779, Col. Narvarte, 03020 Ciudad de Mexico (Mexico)

2015-09-15

In this paper the analysis of scenario for the loss of coolant case was realized with break at the bottom of a recirculation loop of a BWR-5 with containment type Mark II and a thermal power of 2317 MWt considering that not have coolant injection. This in order to observe the speed of progression of the accident, the phenomenology of the scenario, the time to reach the limit pressure of containment venting and the amount of radionuclides released into the environment. This simulation was performed using the MELCOR code version 2.1. The scenario posits a break in one of the shear recirculation loops. The emergency core cooling system (ECCS) and the reactor core isolation cooling (Rcic) have not credit throughout the event, which allowed achieve greater severity on scenario. The venting of the primary containment was conducted via valve of 30 inches instead of the line of 24 inches of wet well, this in order to have a larger area of exhaust of fission products directly to the reactor building. The venting took place when the pressure in the primary containment reached the 4.5 kg/cm{sup 2} and remained open for the rest of the scenario to maximize the amount released of radionuclides to the atmosphere. The safety relief valves were considered functional they do not present mechanical failure or limit their ability to release pressure due to the large number of performances in safety mode. The results of the analysis covers about 48 hours, time at which the accident evolution was observed; behavior of level, pressure in the vessel and the fuel temperature profile was analyzed. For progression of the scenario outside the vessel, the pressure and temperature of the primary containment, level and temperature of the suppression pool, the hydrogen accumulation in the container and the radionuclides mass released into the atmosphere were analyzed. (Author)

Evaluating Early Case Capture of Pediatric Cancers in Seven Central Cancer Registries in the United States, 2013.

Science.gov (United States)

Puckett, Mary; Neri, Antonio; Rohan, Elizabeth; Clerkin, Castine; Underwood, J Michael; Ryerson, A Blythe; Stewart, Sherri L

2016-01-01

Cancer is the second-leading cause of death in children, but incidence data are not available until two years after diagnosis, thereby delaying data dissemination and research. An early case capture (ECC) surveillance program was piloted in seven state cancer registries to register pediatric cancer cases within 30 days of diagnosis. We sought to determine the quality of ECC data and understand pilot implementation. We used quantitative and qualitative methods to evaluate ECC. We assessed data quality by comparing demographic and clinical characteristics from the initial ECC submission to a resubmission of ECC pilot data and to the most recent year of routinely collected cancer data for each state individually and in aggregate. We conducted telephone focus groups with registry staff to determine ECC practices and difficulties in August and September 2013. Interviews were recorded, transcribed, and coded to identify themes. Comparing ECC initial submissions with submissions for all states, ECC data were nationally representative for age (9.7 vs. 9.9 years) and sex (673 of 1,324 [50.9%] vs. 42,609 of 80,547 [52.9%] male cases), but not for primary site (472 of 1,324 [35.7%] vs. 27,547 of 80,547 [34.2%] leukemia/lymphoma cases), behavior (1,219 of 1,324 [92.1%] vs. 71,525 of 80,547 [88.8%] malignant cases), race/ethnicity (781 of 1,324 [59.0%] vs. 64,518 of 80,547 [80.1%] white cases), or diagnostic confirmation (1,233 of 1,324 [93.2%] vs. 73,217 of 80,547 [90.9%] microscopically confirmed cases). When comparing initial ECC data with resubmission data, differences were seen in race/ethnicity (808 of 1,324 [61.1%] vs. 1,425 of 1,921 [74.2%] white cases), primary site (475 of 1,324 [35.9%] vs. 670 of 1,921 [34.9%] leukemia/lymphoma cases), and behavior (1,215 of 1,324 [91.8%] vs. 1,717 of 1,921 [89.4%] malignant cases). Common themes from focus group analysis included implementation challenges and facilitators, benefits of ECC, and utility of ECC data. ECC provided data

Effects of contraction mode and stimulation frequency on electrical stimulation-induced skeletal muscle hypertrophy.

Science.gov (United States)

Ashida, Yuki; Himori, Koichi; Tatebayashi, Daisuke; Yamada, Ryotaro; Ogasawara, Riki; Yamada, Takashi

2018-02-01

We compared the skeletal muscle hypertrophy resulting from isometric (Iso) or eccentric (Ecc) electrical stimulation (ES) training with different stimulation frequencies. Male Wistar rats were assigned to the Iso and Ecc groups. These were divided into three further subgroups that were stimulated at 10 Hz (Iso-10 and Ecc-10), 30 Hz (Iso-30 and Ecc-30), or 100 Hz (Iso-100 and Ecc-100). In experiment 1, the left plantarflexor muscles were stimulated every other day for 3 wk. In experiment 2, mammalian target of rapamycin complex 1 (mTORC1) signaling was investigated 6 h after one bout of ES. The contralateral right muscle served as a control (non-ES). Ecc contractions comprised forced dorsiflexion combined with ES. The peak torque and torque-time integral during ES were higher in the Ecc group than that in the Iso group in all stimulation frequencies examined. The gastrocnemius muscle weight normalized to body weight in ES side was increased compared with the non-ES side by 6, 7, and 17% in the Ecc-30, Iso-100, and Ecc-100 groups, respectively, with a greater gain in Ecc-100 than the Ecc-30 and Iso-100 groups. The p70S6K (Thr389) phosphorylation level was higher in the Ecc-30 and -100 than in the Iso-30 and -100 groups, respectively. The peak torque and torque-time integral were highly correlated with the magnitude of increase in muscle mass and the phosphorylation of p70S6K. These data suggest that ES-induced muscle hypertrophy and mTORC1 activity are determined by loading intensity and volume during muscle contraction independent of the contraction mode. NEW & NOTEWORTHY Eccentric contraction and high-frequency stimulation (HFS) are regarded as an effective way to increase muscle mass by electrical stimulation (ES) training. However, little is known about whether muscle hypertrophy is affected by contraction mode and stimulation frequency in ES training. Here, we provide the evidence that muscle hypertrophy and mammalian target of rapamycin complex 1 activity are

Prevalence, and early childhood caries risk indicators in preschool children in suburban Nigeria.

Science.gov (United States)

Folayan, Morenike O; Kolawole, Kikelomo A; Oziegbe, Elizabeth O; Oyedele, Titus; Oshomoji, Olusegun V; Chukwumah, Nneka M; Onyejaka, Nneka

2015-06-30

Early Childhood Caries (ECC) is defined as the presence of caries lesion in an primary tooth in children below the age of 71 months. It is a significant public health problem with consequences for the growth and development of affected children. The objective of this study was to determine the prevalence and ECC risk indicators in a suburban population in Nigeria. The data of 497 children aged 6 months to 71 months who were recruited through a household survey conducted in Ile-Ife, Nigeria was analysed for prevalence of ECC and risk indicators. Information on children's ages, sex, socioeconomic status, tooth brushing habits, sugary snacks consumption, use of fluoridated toothpaste, birth rank, infant-feeding practices, breastfeeding practices, maternal age at childbirth, and maternal knowledge of oral health was obtained. Children's oral hygiene and caries status was also determined. Risk factors associated with ECC were determined using logistic regression analysis. Thirty-three (6.6%) children had ECC. Four (0.8%) had severe ECC. The four risk indicators for ECC were the child's gender, mothers' knowledge of oral health, consumption of sugary snacks in between meals more than three times a day, and the child's oral hygiene status. Females (PR: -0.06; 95% CI: -0.01- -0.01; p = 0.02), and children with mothers who had good knowledge of oral health (PR: -0.06; 95% CI: -0.11--0.008; p = 0.02) were less likely to have ECC. Children who consumed sugary snacks in between meals three times a day or more (PR: 0.05; CI: 0.003 - 0.01; P = 0.04) and children with fair oral hygiene (PR: 0.05; 95% CI: 0.005-0.10; p = 0.03) were more likely to have ECC. The prevalence of ECC in the study population was low. Promoting good oral hygiene practices and enhancing mothers' knowledge of oral health may help reduce further, the risk for ECC in the study population.

A methodology for the estimation of release of fission products during LOCA with loss of ECCS

International Nuclear Information System (INIS)

Lele, H.G.; Majumdar, P.; Mukhopadhyay, D.; Gupta, S.K.; Venkat Raj, V.

2002-01-01

A Loss of Coolant Accident (LOCA) in a nuclear reactor along with the failure of the Emergency Core Cooling System can cause sustained voiding of the core. In such a situation the core experiences very low flow which leads to poor heat removal from the reactor core. The heat to be removed from the core includes stored heat, heat generated due to metal water reaction at high temperatures, decay heat etc. The poor heat removal leads to heating of the fuel pins to high temperatures. The heating of fuel pins is further enhanced due to metal-water reaction at high temperatures. These high temperatures of the fuel pins can lead to fission product release, which is transported into the Primary Heat Transport (PHT) system and can enter the containment through the break. Analysis is involved due to the complexity of the system and the phenomena to be simulated. In this paper a multistage analysis methodology is presented that involves the development and application of a number of computer programs to model the various phenomena involved. The computer code PHTACT computes the activity release from the fuel as a function of fuel temperatures and cladding oxidation, its distribution into the PHT system and release into the containment. Computation of thermal hydraulic parameters during LOCA is done using the thermal hydraulic analysis code RELAP5. The detailed simulation of fuel pin temperatures is done using computer code HT/MOD4. The convective boundary conditions required for the code are obtained from RELAP5. Creep deformation is considered in the computation of dimensional changes of the coolant channel and estimation of flow blockage due to clad ballooning. The progression of various reaction layers due to high temperature reaction between fuel and clad and clad and steam is also computed, which affects the structural strength of the clad. Different approaches are possible and analysis can be carried out in different phases depending upon the complexities to be

Role of calpain in eccentric contraction-induced proteolysis of Ca2+-regulatory proteins and force depression in rat fast-twitch skeletal muscle.

Science.gov (United States)

Kanzaki, Keita; Watanabe, Daiki; Kuratani, Mai; Yamada, Takashi; Matsunaga, Satoshi; Wada, Masanobu

2017-02-01

The aim of this study was to examine the in vivo effects of eccentric contraction (ECC) on calpain-dependent proteolysis of Ca 2+ -regulatory proteins and force production in fast-twitch skeletal muscles. Rat extensor digitorum longus muscles were exposed to 200 repeated ECC in situ and excised immediately [recovery 0 (REC0)] or 3 days [recovery 3 (REC3)] after cessation of ECC. Calpain inhibitor (CI)-treated rats were intraperitoneally injected with MDL-28170 before ECC and during REC3. Tetanic force was markedly reduced at REC0 and remained reduced at REC3. CI treatment ameliorated the ECC-induced force decline but only at REC3. No evidence was found for proteolysis of dihydropyridine receptor (DHPR), junctophilin (JP)1, JP2, ryanodine receptor (RyR), sarcoplasmic reticulum Ca 2+ -ATPase (SERCA)1a, or junctional face protein-45 at REC0. At REC3, ECC resulted in decreases in DHPR, JP1, JP2, RyR, and SERCA1a. CI treatment prevented the decreases in DHPR, JP1, and JP2, whereas it had little effect on RyR and SERCA1a. These findings suggest that DHPR, JP1, and JP2, but not RyR and SERCA1a, undergo calpain-dependent proteolysis in in vivo muscles subjected to ECC and that impaired function of DHPR and/or JP might cause prolonged force deficits with ECC. NEW & NOTEWORTHY Calpain-dependent proteolysis is one of the contributing factors to muscle damage that occurs with eccentric contraction (ECC). It is unclear, however, whether calpains account for proteolysis of Ca 2+ -regulatory proteins in in vivo muscles subjected to ECC. Here, we provide evidence that dihydropyridine receptor and junctophilin, but not ryanodine receptor and sarcoplasmic reticulum Ca 2+ -ATPase, undergo calpain-dependent proteolysis. Copyright © 2017 the American Physiological Society.

ECCS control circuit

International Nuclear Information System (INIS)

Sato, Takashi.

1986-01-01

Purpose: To afford a sufficient margin to pressure vibrations upon starting of an automatic depressurization system by dispersing pressure vibration in suppression water due to the opening action of an automatic releaf valve in the automatic depressurization system thereby reducing the dynamic load exerted to the surface of the suppression walls. Constitution: Upon occurrence of loss of coolant accidents, an automatic releaf valve for automatic depressurization is opened to deliver the steams in the pressure vessel into the suppression pool. Since a plurality of automatic releaf valves have usually been disposed, if they are opened simultaneously, excess dynamic loads are exerted due to the pressure vibrations to the wall surface of the suppression pool. In this invention, a control circuit is disposed such that the opening timing for each of the automatic releaf valves is deviated upon occurrence of a driving signal for the automatic depressurization system to thereby disperse the pressure vibrations in the suppression water. (Kamimura, M.)

Less counseling on Early Childhood Caries transmission by dentists

Science.gov (United States)

Milgrom, Peter; Huebner, Colleen E.; Mancl, Lloyd; Garson, Gayle; Grembowski, David

2013-01-01

Objective High levels of Streptococcus mutans on teeth of young children are predictive of Early Childhood Caries (ECC). Transmission from mother-to-child is common and studies have demonstrated treatment of the mother results in less ECC. The objective of this study was to determine how dentists have adopted the practice of counseling about ECC. Methods In 2006 as part of a larger study on dental care for pregnant women, we surveyed 829 general dentists in Oregon. The questionnaire contained questions to capture the extent to which general dentists have adopted counseling pregnant women about ECC transmission, to describe personal and practice characteristics, and examine how dentists' views on the ease of adopting of new procedures related to ECC counseling. Multivariate logistic regression was used to identify separate and additive effects of demographic and practice characteristics, attitudes, and beliefs. Results The adjusted odds of a dentist who strongly believed in the link between mothers and babies and provided ECC counseling were 1.60 (95% CI 1.3-2.0, P<0.01). The odds of a dentist who reported discussing ECC with staff members and provided counseling were 2.7 (95% CI 1.7-4.3, P<0.01). Male dentists were less likely to counsel patients than female dentists (Adjusted OR = 0.5, 95% CI 0.3-1.0, p<0.05). Conclusions The strongest predictors of counseling patients about ECC were dentists' belief in the evidence of caries transmission and dentists' discussion of ECC during staff meetings. PMID:22970775

Counseling on Early Childhood Caries transmission by dentists.

Science.gov (United States)

Milgrom, Peter; Huebner, Colleen E; Mancl, Lloyd; Garson, Gayle; Grembowski, David

2013-01-01

High levels of Streptococcus mutans on teeth of young children are predictive of Early Childhood Caries (ECC). Transmission from mother-to-child is common and studies have demonstrated treatment of the mother results in less ECC. The objective of this study was to determine how dentists have adopted the practice of counseling about ECC. In 2006 as part of a larger study on dental care for pregnant women, we surveyed 829 general dentists in Oregon. The questionnaire contained questions to capture the extent to which general dentists have adopted counseling pregnant women about ECC transmission, to describe personal and practice characteristics, and examine how dentists' views on the ease of adopting of new procedures related to ECC counseling. Multivariate logistic regression was used to identify separate and additive effects of demographic and practice characteristics, attitudes, and beliefs. The adjusted odds of a dentist who strongly believed in the link between mothers and babies and provided ECC counseling were 1.60 (95% CI 1.3-2.0, P<0.01). The odds of a dentist who reported discussing ECC with staff members and provided counseling were 2.7 (95% CI 1.7-4.3, P<0.01). Male dentists were less likely to counsel patients than female dentists (Adjusted OR=0.5, 95% CI 0.3-1.0, p<0.05). The strongest predictors of counseling patients about ECC were dentists' belief in the evidence of caries transmission and dentists' discussion of ECC during staff meetings. © 2012 American Association of Public Health Dentistry.

Simulation of a large break loss of coolant (LBLOCA), without actuation of the emergency injection systems (ECCS) for a BWR-5

International Nuclear Information System (INIS)

Cardenas V, J.; Mugica R, C. A.; Lopez M, R.

2015-09-01

In this paper the analysis of scenario for the loss of coolant case was realized with break at the bottom of a recirculation loop of a BWR-5 with containment type Mark II and a thermal power of 2317 MWt considering that not have coolant injection. This in order to observe the speed of progression of the accident, the phenomenology of the scenario, the time to reach the limit pressure of containment venting and the amount of radionuclides released into the environment. This simulation was performed using the MELCOR code version 2.1. The scenario posits a break in one of the shear recirculation loops. The emergency core cooling system (ECCS) and the reactor core isolation cooling (Rcic) have not credit throughout the event, which allowed achieve greater severity on scenario. The venting of the primary containment was conducted via valve of 30 inches instead of the line of 24 inches of wet well, this in order to have a larger area of exhaust of fission products directly to the reactor building. The venting took place when the pressure in the primary containment reached the 4.5 kg/cm 2 and remained open for the rest of the scenario to maximize the amount released of radionuclides to the atmosphere. The safety relief valves were considered functional they do not present mechanical failure or limit their ability to release pressure due to the large number of performances in safety mode. The results of the analysis covers about 48 hours, time at which the accident evolution was observed; behavior of level, pressure in the vessel and the fuel temperature profile was analyzed. For progression of the scenario outside the vessel, the pressure and temperature of the primary containment, level and temperature of the suppression pool, the hydrogen accumulation in the container and the radionuclides mass released into the atmosphere were analyzed. (Author)

[Influence of social environment on caries prevalence in early childhood].

Science.gov (United States)

Tusek, Ivan; Carević, Momir; Tusek, Jasmina

2011-01-01

Early childhood caries (ECC) is a special form of caries that affects decideous teeth with rapid progression and numerous complications. The aim of the study was to define the prevalence of ECC in children of the South Backa area, the importance of social environment for the prevalence and severity of ECC, and define the model for its prevention. The survey was the cross-sectional analytical study in the 10% sample of children, aged 13-64 months, different sex, social status and human environment. Severity and prevalence of ECC were assessed by dental check-ups. The epidemiological data were obtained by the interview of parents. The tests of significant statistical differences were performed by the analysis variance and chi2 (p family (46.9%) and in part-time employed mothers (47.2%) who had only elementary education (59.3%) and were poorly informed about oral health. The highest prevalence (47.1%) of ECC was found in children whose parents had the lowest income per month. Type 1 of ECC was the most presented one (75.0%). The higher prevalence and more severe ECC were found in the third and the next born male child from rural environment.

A comparative evaluation of bifidobacteria levels in early childhood caries and severe early childhood caries

Directory of Open Access Journals (Sweden)

Suraj Nair

2017-01-01

Full Text Available Background: Bifidobacteria levels in saliva were found to be significantly correlated in adults with dental caries but less information available in the literature regarding its role in children. Aim: The aim is to compare the salivary levels of Bifidobacteria in children who are caries free with that of early childhood caries (ECC and severe ECC (S-ECC. Materials and Methods: Saliva was collected using the tongue-loop method from a total of 60 children between the age group of 3–5 years and they were further divided into 3 groups. In addition, the age and gender of the children, sugar amount in diet, sugar frequency in diet, were recorded. Results: Bifidobacteria was isolated from all the three groups, but more were from S-ECC, followed by ECC and very few cases of caries-free children and was found to statistically significant (P < 0.001. Salivary levels of Bifidobacteria were significantly correlated with amount of sugar in the diet and frequency of sugar consumption. Conclusions: Salivary levels of Bifidobacteria were significantly associated with S-ECC and ECC, followed by caries free group. In future, it can be used as a salivary marker for caries risk assesment.

Muscle conduction velocity, surface electromyography variables, and echo intensity during concentric and eccentric fatigue.

Science.gov (United States)

Gonzalez-Izal, Miriam; Lusa Cadore, Eduardo; Izquierdo, Mikel

2014-03-01

Concentric (CON) and eccentric (ECC) contractions may involve different mechanisms related to changes in sarcolemma status and the consequent alteration of action potential transmission along muscle fibers. Muscle conduction velocity (CV), surface electromyography signal (sEMG), muscle quality, and blood lactate concentrations were analyzed during CON and ECC actions. Compared with ECC, the CON protocol resulted in greater muscle force losses, blood lactate concentrations, and changes in sEMG parameters. Similar reductions in CV were detected in both protocols. Higher echo intensity values were observed 2 days after ECC due to greater muscle damage. The effects of the muscle damage produced by ECC exercise on the transmission of action potentials along muscle fibers (measured as the CV) may be comparable with the effects of hydrogen accumulation produced by CON exercise (related to greater lactate concentrations), which causes greater force loss and change in other sEMG variables during CON than during ECC actions.

9 CFR 590.520 - Breaking room facilities.

Science.gov (United States)

2010-01-01

..., clean towels or other facilities for drying hands, odorless soap, and containers for used towels. Hand... egg products are not acceptable as liquid egg buckets. (g) A suitable container conspicuously identified shall be provided for the disposal of rejected liquid. (h) Strainers, filters, or centrifugal...

Strengthening masonry infill panels using engineered cementitious composites

DEFF Research Database (Denmark)

Dehghani, Ayoub; Fischer, Gregor; Nateghi Alahi, Fariborz

2015-01-01

for ECC in order to assess its distinctive mechanical properties such as tensile stress–strain behavior and multiple cracking. To investigate the influence of a thin layer of ECC on plain masonry in terms of changes in stiffness, strength, and deformability, small scale tests have been conducted...... and strength properties, including the post-peak softening behavior in view of seismic applications. The obtained resultsindicate that the proposed ECC-strengthening technique can effectively increase the shear capacity of masonry panels, improve their deformability, enhance their energy absorption capacity......, and prevent the brittle failure mode. Furthermore, the superior deformability of ECC is clearly reflected by cracks development in the ECC layer, which was monitored by a high resolution camera and was analyzed using Digital Image Correlation (DIC) technique....

Influence of social environment on caries prevalence in early childhood

Directory of Open Access Journals (Sweden)

Tušek Ivan

2011-01-01

Full Text Available Introduction. Early childhood caries (ECC is a special form of caries that affects decideous teeth with rapid progression and numerous complications. Objective. The aim of the study was to define the prevalence of ECC in children of the South Bačka area, the importance of social environment for the prevalence and severity of ECC, and define the model for its prevention. Methods. The survey was the cross-sectional analytical study in the 10% sample of children, aged 13-64 months, different sex, social status and human environment. Severity and prevalence of ECC were assessed by dental check-ups. The epidemiological data were obtained by the interview of parents. The tests of significant statistical differences were performed by the analysis variance and χ2 (p<0.05 test, as well as interdependence of ECC and single characteristics that could be a predictor of the disease by the logistic regression. Results. The prevalence of ECC was 30.5%. The highest disease frequency was found in children of male sex (35.1%, out of kindergardens (54.2%, in the third and the next born child in the family (46.9% and in part-time employed mothers (47.2% who had only elementary education (59.3% and were poorly informed about oral health. The highest prevalence (47.1% of ECC was found in children whose parents had the lowest income per month. Type 1 of ECC was the most presented one (75.0%. Conclusion. The higher prevalence and more severe ECC were found in the third and the next born male child from rural environment.

Extrachromosomal circles of satellite repeats and 5S ribosomal DNA in human cells

Directory of Open Access Journals (Sweden)

Cohen Sarit

2010-03-01

Full Text Available Abstract Background Extrachomosomal circular DNA (eccDNA is ubiquitous in eukaryotic organisms and was detected in every organism tested, including in humans. A two-dimensional gel electrophoresis facilitates the detection of eccDNA in preparations of genomic DNA. Using this technique we have previously demonstrated that most of eccDNA consists of exact multiples of chromosomal tandemly repeated DNA, including both coding genes and satellite DNA. Results Here we report the occurrence of eccDNA in every tested human cell line. It has heterogeneous mass ranging from less than 2 kb to over 20 kb. We describe eccDNA homologous to human alpha satellite and the SstI mega satellite. Moreover, we show, for the first time, circular multimers of the human 5S ribosomal DNA (rDNA, similar to previous findings in Drosophila and plants. We further demonstrate structures that correspond to intermediates of rolling circle replication, which emerge from the circular multimers of 5S rDNA and SstI satellite. Conclusions These findings, and previous reports, support the general notion that every chromosomal tandem repeat is prone to generate eccDNA in eukryoric organisms including humans. They suggest the possible involvement of eccDNA in the length variability observed in arrays of tandem repeats. The implications of eccDNA on genome biology may include mechanisms of centromere evolution, concerted evolution and homogenization of tandem repeats and genomic plasticity.

Application of fundamental principles to mineral scale reduction : case studies

Science.gov (United States)

Peter W. Hart; Alan W. Rudie

2005-01-01

This paper will present several successful case studies where scale has been eliminated in mills including calcium carbonate scale in a white liquor strainer, calcium oxalate scale in the D0 stage, enzymatic treatment of brown stock to eliminate oxalate scale, and control of barium sulfate scale.

Coil-springs used as mechanical filter. Modification of the bottom tie plate of a fuel assembly

International Nuclear Information System (INIS)

Nylund, O.

1993-01-01

Describes an improved design of the bottom tie plate of a fuel assembly. The improvement of the design is an arrangement of horizontal channels holding coil-springs and crossing the vertical channels for the cooling water. The coil-springs work as strainers for the cooling water

Chronic Disease Management Strategies of Early Childhood Caries: Support from the Medical and Dental Literature.

Science.gov (United States)

Edelstein, Burton L; Ng, Man Wai

2015-01-01

An Institute of Medicine report places chronic disease management (CDM) as an intervention on a treatment spectrum between prevention and acute care. CDM commonly focuses on conditions in which patient self-care efforts are significant. Framing early childhood caries (ECC) as such a chronic condition invites dentistry to reconsider its approach to caries management and shift gears from a strictly surgical approach to one that also incorporates a medical approach. This paper's purpose was to explore the definition of and concepts inherent in CDM. An explanatory model is introduced to describe the multiple factors that influence ECC-CDM strategies. Reviewed literature suggests that early evidence from ECC-CDM interventions, along with results of pediatric asthma and diabetes CDM, supports CDM of ECC as a valid approach that is independent of both prevention and repair. Early results of ECC-CDM endeavors have demonstrated a reduction in rates of new cavitation, dental pain, and referral to the operating room compared to baseline rates. ECC-CDM strategies hold strong promise to curtail caries activity while complementing dental repair when needed, thereby reducing disease progression and cavity recurrence. Institutionalizing ECC-CDM will both require and benefit from evolving health care delivery and financing systems that reward positive health outcomes.

Renin angiotensin system blockage associates with insertion/deletion polymorphism of angiotensin-converting enzyme in patients with hypertensive emergency.

Science.gov (United States)

Vilela-Martin, José F; Vaz-de-Melo, Renan O; Cosenso-Martin, Luciana N; Kuniyoshi, Cristina H; Yugar-Toledo, Juan C; Pinhel, Marcela A S; de Souza, Gisele F; Souza, Dorotéia R S; Pimenta, Eduardo; Moreno, Heitor; Cipullo, José P

2013-09-01

Hypertensive crisis (HC) stands out as a form of acute elevation of blood pressure (BP). It can manifest itself as hypertensive emergency (HE) or hypertensive urgency (HU), which is usually accompanied with levels of diastolic BP ≥120 mmHg. Angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism may influence manifestations of HC. Thus, this study evaluated the influence of ACE I/D polymorphism in individuals with HC. A total of 187 patients admitted with HC (HU [n=69] and HE [n=118]) and 75 normotensive individuals were included in the study. Peripheral blood was drawn for a biochemical and genetic analysis of the ACE I/D polymorphism by Polymerase Chain Reaction. HC group showed higher systolic BP, body mass index (BMI), glycemia, creatinine, and lower high-density lipoprotein (HDL) cholesterol compared with normotensive individuals. The use of renin-angiotensin system (RAS) blockers was more frequent in the HU group than in the HE group (p=0.020). The II genotype was more predominant in normotensive and HU individuals than among HE individuals (18.7%, 11.6%, and 2.5%, respectively; p=0.004). Higher BMI and glycemia were associated with HC in the logistic regression model. ACE II genotype (odds ratio [OR] 0.14; 95% confidence interval [CI] 0.04-0.51) and HDL cholesterol were protective for the development of HE. ACE II genotype was present in the HU group, compared with the HE group (OR 0.18; 95% CI 0.04-0.88). This study shows an association between the low prevalence of ACE I/D polymorphism II genotype and a greater occurrence of HE in Brazilian individuals. The lower blockage of RAS, which was detected in the HE group, may interact with the low frequency of II genotype, conferring an increased risk for HE.

Multi-location gram-positive and gram-negative bacterial protein subcellular localization using gene ontology and multi-label classifier ensemble.

Science.gov (United States)

Wang, Xiao; Zhang, Jun; Li, Guo-Zheng

2015-01-01

It has become a very important and full of challenge task to predict bacterial protein subcellular locations using computational methods. Although there exist a lot of prediction methods for bacterial proteins, the majority of these methods can only deal with single-location proteins. But unfortunately many multi-location proteins are located in the bacterial cells. Moreover, multi-location proteins have special biological functions capable of helping the development of new drugs. So it is necessary to develop new computational methods for accurately predicting subcellular locations of multi-location bacterial proteins. In this article, two efficient multi-label predictors, Gpos-ECC-mPLoc and Gneg-ECC-mPLoc, are developed to predict the subcellular locations of multi-label gram-positive and gram-negative bacterial proteins respectively. The two multi-label predictors construct the GO vectors by using the GO terms of homologous proteins of query proteins and then adopt a powerful multi-label ensemble classifier to make the final multi-label prediction. The two multi-label predictors have the following advantages: (1) they improve the prediction performance of multi-label proteins by taking the correlations among different labels into account; (2) they ensemble multiple CC classifiers and further generate better prediction results by ensemble learning; and (3) they construct the GO vectors by using the frequency of occurrences of GO terms in the typical homologous set instead of using 0/1 values. Experimental results show that Gpos-ECC-mPLoc and Gneg-ECC-mPLoc can efficiently predict the subcellular locations of multi-label gram-positive and gram-negative bacterial proteins respectively. Gpos-ECC-mPLoc and Gneg-ECC-mPLoc can efficiently improve prediction accuracy of subcellular localization of multi-location gram-positive and gram-negative bacterial proteins respectively. The online web servers for Gpos-ECC-mPLoc and Gneg-ECC-mPLoc predictors are freely accessible

Higher body mass index associated with severe early childhood caries.

Science.gov (United States)

Davidson, Katherine; Schroth, Robert J; Levi, Jeremy A; Yaffe, Aaron B; Mittermuller, Betty-Anne; Sellers, Elizabeth A C

2016-08-20

Severe Early Childhood Caries (S-ECC) is an aggressive form of tooth decay in preschool children affecting quality of life and nutritional status. The purpose was to determine whether there is an association between Body Mass Index (BMI) and S-ECC. Children with S-ECC were recruited on the day of their slated dental surgery under general anesthesia. Age-matched, caries-free controls were recruited from the community. All children were participating in a larger study on nutrition and S-ECC. Analysis was restricted to children ≥ 24 months of age. Parents completed a questionnaire and heights and weights were recorded. BMI scores and age and gender adjusted BMI z-scores and percentiles were calculated. A p-value ≤ 0.05 was significant. Two hundred thirty-five children were included (141 with S-ECC and 94 caries-free). The mean age was 43.3 ± 12.8 months and 50.2 % were male. Overall, 34.4 % of participants were overweight or obese. Significantly more children with S-ECC were classified as overweight or obese when compared to caries-free children (p = 0.038) and had significantly higher mean BMI z-scores than caries-free children (0.78 ± 1.26 vs. 0.22 ± 1.36, p = 0.002). Those with S-ECC also had significantly higher BMI percentiles (69.0 % ± 29.2 vs. 56.8 % ± 31.7, p = 0.003). Multiple linear regression analyses revealed that BMI z-scores were significantly and independently associated with S-ECC and annual household income as were BMI percentiles. Children with S-ECC in our sample had significantly higher BMI z-scores than caries-free peers.

Parental Factors Influencing the Development of Early Childhood Caries in Developing Nations: A Systematic Review

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Nayanjot Kaur Rai

2018-03-01

Full Text Available BackgroundEarly childhood caries (ECC is one of the most prevalent and chronic conditions of childhood. Various factors including biological and dietary factors along with an overlay of parental social factors have been found to be associated with the progression of ECC. The objective of this systematic review is to synthesize available literature and to identify parent-level proximal and distal risk factors associated with the development of ECC in developing nations.MethodsStudies conducted in developing nations, published between 2005 and 2017 in English, that included children younger than 6 years and examined ECC were included. The outcome of interest were parental risk factors, which included parental knowledge, behavior, attitudes, sense of coherence (SOC, stress, socioeconomic status (SES, education, and breastfeeding duration. The studies were retrieved from MEDLINE, Ovid Medline, and PubMed.ResultsThe search yielded 325 studies, of which 18 were considered eligible for inclusion in this review. Ten studies found maternal education, and seven studies found parental education to be significantly associated with ECC. SES was significantly associated with ECC in 13 studies in the form of annual household income and occupation level. Four studies observed the significant association between oral health knowledge and attitudes with ECC, whereas only two studies found maternal attitude to be associated with ECC. Breastfeeding duration was a significant risk factor in four studies. One study each found significant associations of SOC, parental distress, and secondary smoke with ECC.ConclusionTo date, most of the researches done in developing countries have reported distal parental factors such as income and education being significant risk factors in caries development compared to proximal risk factors in low-income groups. Only a few studies analyzed the psychosocial and behavioral factors. Interventions could be designed to improve

Utilization of Local Ingredients for the Production of High-Early-Strength Engineered Cementitious Composites

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Hanwen Deng

2018-01-01

Full Text Available The rapid repair and retrofitting of existing transportation infrastructure requires dimensional stability and ductile repair material that can obtain sufficiently high strength in a few hours to accommodate the large loading and deformation at an early age. Engineering cementitious composites (ECCs is a class representative of the new generation of high-performance fiber-reinforced cement-based composites (HPFRCC with medium fiber content. The unique properties of tremendous ductility and tight multiple crack behavior indicate that ECC can be used as an effective retrofit material. The wide application of this material in China will require the use of all local ingredients. In this study, based on Chinese domestic ingredients, including matrix materials and all fibers, high-early-strength ECC (HES-ECC was designed under the guidance of strain-hardening criterion of ECC. The matrix properties and fiber/matrix interfacial micromechanics properties were obtained from three-point-bending test and single-fiber pullout test. The mechanical properties of HES-ECC were achieved by direct tensile test. The experimental results show that HES-ECC was successfully developed by using all Chinese materials. When using the domestic PVA fiber at 2%, the strength requirement can be achieved but only a low ductility. When using the domestic PE fiber at 0.8%, the strength and deformation requirement both can be obtained. The HES-ECC developed in this study exhibited compressive strength of more than 25 MPa within 6 hours, and an ultimate tensile strength of 5-6 MPa and tensile strain capacity of 3-4% after 60 days. Moreover, the cost of using domestic fiber can be largely reduced compared with using imported fiber, up to 70%; it is beneficial to the promotion of these high-early-strength ECCs in the Chinese market.

Impact of physical fitness and biometric data on the quality of external chest compression: a randomised, crossover trial

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Russo Sebastian G

2011-11-01

Full Text Available Abstract Background During circulatory arrest, effective external chest compression (ECC is a key element for patient survival. In 2005, international emergency medical organisations changed their recommended compression-ventilation ratio (CVR from 15:2 to 30:2 to acknowledge the vital importance of ECC. We hypothesised that physical fitness, biometric data and gender can influence the quality of ECC. Furthermore, we aimed to determine objective parameters of physical fitness that can reliably predict the quality of ECC. Methods The physical fitness of 30 male and 10 female healthcare professionals was assessed by cycling and rowing ergometry (focussing on lower and upper body, respectively. During ergometry, continuous breath-by-breath ergospirometric measurements and heart rate (HR were recorded. All participants performed two nine-minute sequences of ECC on a manikin using CVRs of 30:2 and 15:2. We measured the compression and decompression depths, compression rates and assessed the participants' perception of exhaustion and comfort. The median body mass index (BMI; male 25.4 kg/m2 and female 20.4 kg/m2 was used as the threshold for subgroup analyses of participants with higher and lower BMI. Results HR during rowing ergometry at 75 watts (HR75 correlated best with the quality of ECC (r = -0.57, p 75, the compression depth decreased over time, beginning after four minutes for the 15:2 CVR and after three minutes for the 30:2 CVR. Although found to be more exhausting, a CVR of 30:2 was rated as being more comfortable. Conclusion The quality of the ECC and fatigue can both be predicted by BMI and physical fitness. An evaluation focussing on the upper body may be a more valid predictor of ECC quality than cycling based tests. Our data strongly support the recommendation to relieve ECC providers after two minutes.

Listening to the Voice of the Customer.

Science.gov (United States)

Schauerman, Sam; And Others

One of the major tenets of Total Quality Management (TQM) is that organizations need to adopt a strong customer focus. At El Camino College (ECC) in Torrance, California, a matrix was developed to identify and describe ECC's direct and indirect internal and external customers. ECC then applied Quality Function Deployment (QFD), a strategic tool…

Predicted VO2max and effectiveness of external chest compression by Chinese nurses.

Science.gov (United States)

Ho, Leo S T; Jones, Alice Y M; Rainer, Timothy H

2017-08-01

The aims of this study were to assess the influence of sex and body position on external chest compression (ECC) to a manikin by Chinese nurses and to determine the relationship between rescuer's predicted VO2max and ECC depth. A total of 40 nurses performed ECC on a manikin for 5 min in the standing (S) and bed-mount kneeling (K) position, then completed a Chester step-test, in 3 separate days. The rate and depth of compressions and oxygen consumption during ECC were measured. Mean compression rate recorded was above 100/min in both positions throughout ECC. Mean compression depth for male participants was more than 38 mm for 5 min in the K-position but only 3 min in the S-position. Female participants achieved this compression depth for less than 90 s in the K-position but not at all in the S-position. Irrespective of sex, the K-position appears to facilitate effective ECC. The relationship between aerobic fitness of female nurses and their ability to perform effective cardiopulmonary resuscitation warrants further investigation.

Experiment data of ROSA-III integral test Run 7341

International Nuclear Information System (INIS)

Anoda, Yoshinari; Soda, Kunihisa; Tasaka, Kanji

1983-02-01

This report presents the test data of Run 7341 in the single failure test series of the ROSA-III program to conduct the system effect test concerning the response of a BWR during a LOCA with the ECC injection. The ROSA-III test facility is a volumetrically scaled (1/424) system of the BWR/6 with an electrically heated core and the scaled ECCS. Run 7341 is a double-ended break test at the recirculation pump inlet with the assumption that all ECCS function as designed. The test is initiated with the steam dome pressure of 7.28 MPa, the lower plenum subcooling of 11.0 K, the core inlet flow rate of 15.3 kg/s, and the core heat generation rate of 3.55 MW and proceeded as planned. The whole core is quenched after the ECCS actuation and the maximum fuel cladding temperature is 810 K. The effectiveness of ECC injection has been clarified from the comparison of the test results with those of the other test in the series without ECCS. (author)

The acute response of pericytes to muscle-damaging eccentric contraction and protein supplementation in human skeletal muscle.

Science.gov (United States)

De Lisio, Michael; Farup, Jean; Sukiennik, Richard A; Clevenger, Nicole; Nallabelli, Julian; Nelson, Brett; Ryan, Kelly; Rahbek, Stine K; de Paoli, Frank; Vissing, Kristian; Boppart, Marni D

2015-10-15

Skeletal muscle pericytes increase in quantity following eccentric exercise (ECC) and contribute to myofiber repair and adaptation in mice. The purpose of the present investigation was to examine pericyte quantity in response to muscle-damaging ECC and protein supplementation in human skeletal muscle. Male subjects were divided into protein supplement (WHY; n = 12) or isocaloric placebo (CHO; n = 12) groups and completed ECC using an isokinetic dynamometer. Supplements were consumed 3 times/day throughout the experimental time course. Biopsies were collected prior to (PRE) and 3, 24, 48, and 168 h following ECC. Reflective of the damaging protocol, integrin subunits, including α7, β1A, and β1D, increased (3.8-fold, 3.6-fold and 3.9-fold, respectively, P muscle-damaging ECC increases α7β1 integrin content in human muscle, yet pericyte quantity is largely unaltered. Future studies should focus on the capacity for ECC to influence pericyte function, specifically paracrine factor release as a mechanism toward pericyte contribution to repair and adaptation postexercise. Copyright © 2015 the American Physiological Society.

Comparative molecular analysis of early and late cancer cachexia-induced muscle wasting in mouse models.

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Sun, Rulin; Zhang, Santao; Lu, Xing; Hu, Wenjun; Lou, Ning; Zhao, Yan; Zhou, Jia; Zhang, Xiaoping; Yang, Hongmei

2016-12-01

Cancer-induced muscle wasting, which commonly occurs in cancer cachexia, is characterized by impaired quality of life and poor patient survival. To identify an appropriate treatment, research on the mechanism underlying muscle wasting is essential. Thus far, studies on muscle wasting using cancer cachectic models have generally focused on early cancer cachexia (ECC), before severe body weight loss occurs. In the present study, we established models of ECC and late cancer cachexia (LCC) and compared different stages of cancer cachexia using two cancer cachectic mouse models induced by colon-26 (C26) adenocarcinoma or Lewis lung carcinoma (LLC). In each model, tumor-bearing (TB) and control (CN) mice were injected with cancer cells and PBS, respectively. The TB and CN mice, which were euthanized on the 24th day or the 36th day after injection, were defined as the ECC and ECC-CN mice or the LCC and LCC-CN mice. In addition, the tissues were harvested and analyzed. We found that both the ECC and LCC mice developed cancer cachexia. The amounts of muscle loss differed between the ECC and LCC mice. Moreover, the expression of some molecules was altered in the muscles from the LCC mice but not in those from the ECC mice compared with their CN mice. In conclusion, the molecules with altered expression in the muscles from the ECC and LCC mice were not exactly the same. These findings may provide some clues for therapy which could prevent the muscle wasting in cancer cachexia from progression to the late stage.

Magnetic properties of soft layer/FePt-MgO exchange coupled composite Perpendicular recording media

Institute of Scientific and Technical Information of China (English)

Yin Jin-Hua; Takao Suzuki; Pan Li-Qing

2008-01-01

The magnetic properties of exchange coupled composite(ECC)media that are composed of perpendicular magnetic recording media FePt-MgO and two kinds of soft layers have been studied by using an x-ray diffractometer,a polar Kerr magneto-optical system(PMOKE)and a vibrating sample magnetometer(VSM).The results show that ECC media can reduce the coercivities of perpendicular magnetic recording media FePt-MgO.The ECC media with granular-type soft layers have weaker exchange couplings between magnetic grains and the magnetization process,for ECC media of this kind mainly follow the Stoner-Wohlfarth model.

Generation of scenarios from calibrated ensemble forecasts with a dual ensemble copula coupling approach

DEFF Research Database (Denmark)

Ben Bouallègue, Zied; Heppelmann, Tobias; Theis, Susanne E.

2016-01-01

the original ensemble forecasts. Based on the assumption of error stationarity, parametric methods aim to fully describe the forecast dependence structures. In this study, the concept of ECC is combined with past data statistics in order to account for the autocorrelation of the forecast error. The new...... approach, called d-ECC, is applied to wind forecasts from the high resolution ensemble system COSMO-DE-EPS run operationally at the German weather service. Scenarios generated by ECC and d-ECC are compared and assessed in the form of time series by means of multivariate verification tools and in a product...

Early childhood caries in preschool children of gram panchayat Anoo, Hamirpur, Himachal Pradesh

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Shikha Dogra

2018-01-01

Full Text Available Aim and Objectives: A study on prevalence and associated etiological factors of ECC. This study aimed to find the prevalence of ECC and the associated factors among preschool children in Anoo village, Hamirpur district (H.P. Materials and Methods: A sample of 65 children of age between 1 to 5 years was selected from anganwadi units of Anoo village. Dental caries was recorded and information regarding risk factors for caries was obtained through a questionnaire given to mothers or caretakers. Result: The prevalence of ECC was 55.38% and there was a strong association of ECC with some of the risk factors studied. Conclusion: The study emphasizes the need of dental health programs in preschool children. Increasing the awareness regarding maintaining good oral hygiene and encouraging the intake of healthy snacks in children can reduce ECC in concerned population.

Parenting style and oral health practices in early childhood caries: a case-control study.

Science.gov (United States)

Dabawala, Suhel; Suprabha, Baranya S; Shenoy, Ramya; Rao, Arathi; Shah, Nachiket

2017-03-01

There is a need to carry out controlled investigations regarding risk factors for early childhood caries (ECC). To study the type of parenting style and oral health practices as risk factors among children with ECC in an Indian preschool population. Two hundred and eleven children with ECC and equal number of controls participated in this case-control study. A questionnaire was answered by parents regarding oral health practices such as oral hygiene methods, feeding habits, daily sugar intake, and dental attendance pattern along with socioeconomic and demographic status. The parenting style was determined using Parenting Styles Dimension Questionnaire (PSDQ) index. Data were statistically analyzed using chi-square test and multiple logistic regression analysis. Risk factors associated with ECC were higher birth order, lower socioeconomic status, non-use of fluoridated toothpaste, breast/bottle feeding for more than one year, presence of formula milk or milk with sugar in the feeding bottle while falling asleep, higher sweet scores in the diet chart, and visiting dentist only when a problem was perceived. Majority of parents of children with and without ECC had authoritative parenting style. Improper oral health practices are the risk factors for ECC. The association of parenting style with ECC could not be confirmed. © 2016 BSPD, IAPD and John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Model of excitation-contraction coupling of rat neonatal ventricular myocytes.

Science.gov (United States)

Korhonen, Topi; Hänninen, Sandra L; Tavi, Pasi

2009-02-01

The neonatal rat ventricular myocyte culture is one of the most popular experimental cardiac cell models. To our knowledge, the excitation-contraction coupling (ECC) of these cells, i.e., the process linking the electrical activity to the cytosolic Ca2+ transient and contraction, has not been previously analyzed, nor has it been presented as a complete system in detail. Neonatal cardiomyocytes are in the postnatal developmental stage, and therefore, the features of their ECC differ vastly from those of adult ventricular myocytes. We present the first complete analysis of ECC in these cells by characterizing experimentally the action potential and calcium signaling and developing the first mathematical model of ECC in neonatal cardiomyocytes that we know of. We show that in comparison to adult cardiomyocytes, neonatal cardiomyocytes have long action potentials, heterogeneous cytosolic Ca2+ signals, weaker sarcoplasmic reticulum Ca2+ handling, and stronger sarcolemmal Ca2+ handling, with a significant contribution by the Na+/Ca2+ exchanger. The developed model reproduces faithfully the ECC of rat neonatal cardiomyocytes with a novel description of spatial cytosolic [Ca2+] signals. Simulations also demonstrate how an increase in the cell size (hypertrophy) affects the ECC in neonatal cardiomyocytes. This model of ECC in developing cardiomyocytes provides a platform for developing future models of cardiomyocytes at different developmental stages.

Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation.

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Stefanie Krajewski

Full Text Available Extracorporeal circulation (ECC and hypothermia are used to maintain stable circulatory parameters and improve the ischemia tolerance of patients in cardiac surgery. However, ECC and hypothermia induce activation mechanisms in platelets and leukocytes, which are mediated by the platelet agonist ADP and the phosphoinositide-3-kinase (PI3K p110β. Under clinical conditions these processes are associated with life-threatening complications including thromboembolism and inflammation. This study analyzes effects of ADP receptor P(2Y(12 and P(2Y(1 blockade and PI3K p110β inhibition on platelets and granulocytes during hypothermic ECC. Human blood was treated with the P(2Y(12 antagonist 2-MeSAMP, the P(2Y(1 antagonist MRS2179, the PI3K p110β inhibitor TGX-221, combinations thereof, or PBS and propylene glycol (controls. Under static in vitro conditions a concentration-dependent effect regarding the inhibition of ADP-induced platelet activation was found using 2-MeSAMP or TGX-221. Further inhibition of ADP-mediated effects was achieved with MRS2179. Next, blood was circulated in an ex vivo ECC model at 28°C for 30 minutes and various platelet and granulocyte markers were investigated using flow cytometry, ELISA and platelet count analysis. GPIIb/IIIa activation induced by hypothermic ECC was inhibited using TGX-221 alone or in combination with P(2Y blockers (p<0.05, while no effect of hypothermic ECC or antiplatelet agents on GPIIb/IIIa and GPIbα expression and von Willebrand factor binding was observed. Sole P(2Y and PI3K blockade or a combination thereof inhibited P-selectin expression on platelets and platelet-derived microparticles during hypothermic ECC (p<0.05. P(2Y blockade alone or combined with TGX-221 prevented ECC-induced platelet-granulocyte aggregate formation (p<0.05. Platelet adhesion to the ECC surface, platelet loss and Mac-1 expression on granulocytes were inhibited by combined P(2Y and PI3K blockade (p<0.05. Combined blockade of P

The efficacy and safety of dual blockage of the renin-angiotensin-aldosterone system in patients with type 2 diabetes, hypertension and obesity without renal dysfunction

Directory of Open Access Journals (Sweden)

2012-09-01

Full Text Available The purpose of the study was to evaluate the clinical efficacy and safety of dual RAAS blockage during treatment with angiotensin-converting enzyme (ACE inhibitors in combination with a direct renin inhibitor (PIR aliskiren versus combination therapy with ACE inhibitors and angiotensin receptor blocker II (ARB valsartan in patients with type 2 diabetes mellitus (T2DM, arterial hypertension (AH and obesity, without renal dysfunction. Materials and methods. The study included 26 patients with T2DM (10 men and 16 women, mean age 59,0±6,2 years with inadequate control of blood pressure (over 130 and/or 80 mm Hg on prior antihypertensive therapy and without renal dysfunctions (glomerular filtration rate (GFR> 60 ml/min/1, 73 m2 and the of albumin/creatinine (A/C ratio in the morning urine sample <10 mg/mol. After screening with the continuation of the initial therapy, including ACE inhibitors, 14 patients were added aliskiren 150–300 mg/day, 12 patients – valsartan 80–160 mg/day. Evaluation of the treatment effectiveness in terms of blood pressure (mean of three consecutive measurements in the sitting position and the parameters of renal function (serum creatinine and potassium, GFR, A/C ratio in the urine was performed at 4, 12 and 24 weeks of therapy. Results. In the group of patients treated with aliskiren, after 4 weeks of treatment a significant decrease in systolic and diastolic blood pressure (SBP and DBP, respectively was noted as compared to baseline: 146,1 and 138,9 mm Hg, p<0,05, 87,1 and 81,1 mm Hg, p <0,05, respectively; with systolic BP after 24 weeks of treatment decreased to 127,8 (-18,2 mm Hg, p<0,05, diastolic BP to 75,0 (-12, 1 mm Hg, p<0,05, the target blood pressure (≤130/80 mm Hg was achieved in 83% of patients. The group of patients treated with valsartan, after 4 weeks of therapy showed a significant reduction in systolic BP 148 and 141,6 mm Hg, p <0,05, diastolic BP - to 85,8 and 81,7 mm Hg, p=0,059; after 24 weeks

46 CFR 169.231 - Definitions relating to hull examinations.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Definitions relating to hull examinations. 169.231... hull examinations. As used in the part— (a) Drydock examination means hauling out a vessel or placing a... and all through-hull fittings, sea chests, sea valves, sea strainers, and valves for the emergency...

Rice weevil response to basil oil fumigation

Science.gov (United States)

Basil oil, Ocimum basilicum L., is a volatile plant essential oil that is known to have insecticidal activity against stored product pests such as rice weevil, Sitophilus oryzae (L.). Basil oil was diluted in acetone and applied to a sponge held inside a tea strainer for fumigations in containers wi...

Design and Micromagnetic Simulation of Fe/L10-FePt/Fe Trilayer for Exchange Coupled Composite Bit Patterned Media at Ultrahigh Areal Density

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Warunee Tipcharoen

2015-01-01

Full Text Available Exchange coupled composite bit patterned media (ECC-BPM are one candidate to solve the trilemma issues, overcome superparamagnetic limitations, and obtain ultrahigh areal density. In this work, the ECC continuous media and ECC-BPM of Fe/L10-FePt/Fe trilayer schemes are proposed and investigated based on the Landau-Lifshitz-Gilbert equation. The switching field, Hsw, of the hard phase in the proposed continuous ECC trilayer media structure is reduced below the maximum write head field at interlayer exchange coupling between hard and soft phases, Aex, higher than 20 pJ/m and its value is lower than that for continuous L10-FePt single layer media and L10-FePt/Fe bilayer. Furthermore, the Hsw of the proposed ECC-BPM is lower than the maximum write head field with exchange coupling coefficient between neighboring dots of 5 pJ/m and Aex over 10 pJ/m. Therefore, the proposed ECC-BPM trilayer has the highest potential and is suitable for ultrahigh areal density magnetic recording technology at ultrahigh areal density. The results of this work may be gainful idea for nanopatterning in magnetic media nanotechnology.

Analysis on applicable error-correcting code strength of storage class memory and NAND flash in hybrid storage

Science.gov (United States)

Matsui, Chihiro; Kinoshita, Reika; Takeuchi, Ken

2018-04-01

A hybrid of storage class memory (SCM) and NAND flash is a promising technology for high performance storage. Error correction is inevitable on SCM and NAND flash because their bit error rate (BER) increases with write/erase (W/E) cycles, data retention, and program/read disturb. In addition, scaling and multi-level cell technologies increase BER. However, error-correcting code (ECC) degrades storage performance because of extra memory reading and encoding/decoding time. Therefore, applicable ECC strength of SCM and NAND flash is evaluated independently by fixing ECC strength of one memory in the hybrid storage. As a result, weak BCH ECC with small correctable bit is recommended for the hybrid storage with large SCM capacity because SCM is accessed frequently. In contrast, strong and long-latency LDPC ECC can be applied to NAND flash in the hybrid storage with large SCM capacity because large-capacity SCM improves the storage performance.

Review of evaluation on ecological carrying capacity: The progress and trend of methodology

Science.gov (United States)

Wang, S. F.; Xu, Y.; Liu, T. J.; Ye, J. M.; Pan, B. L.; Chu, C.; Peng, Z. L.

2018-02-01

The ecological carrying capacity (ECC) has been regarded as an important reference to indicate the level of regional sustainable development since the very beginning of twenty-first century. By a brief review of the main progress in ECC evaluation methodologies in recent five years, this paper systematically discusses the features and differences of these methods and expounds the current states and future development trend of ECC methodology. The result shows that further exploration in terms of the dynamic, comprehensive and intelligent assessment technologies needs to be provided in order to form a unified and scientific ECC methodology system and to produce a reliable basis for environmental-economic decision-makings.

PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor

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Leyla Esfandiari

2016-07-01

Full Text Available A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL depending on cellular rRNA levels. The development of a rapid, sensitive, and cost-effective nucleic acid detection platform is sought for the detection of pathogenic microbes in food, water and body fluids. Since 16S rRNA sequences are species specific and are present at high copy number in viable cells, these nucleic acids offer an attractive target for microbial pathogen detection schemes. Here, target 16S rRNA of E. coli at 10 fM concentration was detected against a total RNA background using a conceptually simple approach based on electromechanical signal transduction, whereby a step change reduction in ionic current through a pore indicates blockage by an electrophoretically mobilized bead-peptide nucleic acid probe conjugate hybridized to target nucleic acid. We investigated the concentration detection limit for bacterial species-specific 16S rRNA at 1 pM to 1 fM and found a limit of detection of 10 fM for our device, which is consistent with our previous finding with single-stranded DNA of similar length. In addition, no false positive responses were obtained with control RNA and no false negatives with target 16S rRNA present down to the limit of detection (LOD of 10 fM. Thus, this detection scheme shows promise for integration into portable, low-cost systems for rapid detection of pathogenic microbes in food, water and body fluids.

Lung Transplantation in Cystic Fibrosis and the Impact of Extracorporeal Circulation.

Science.gov (United States)

Jauregui, Alberto; Deu, Maria; Romero, Laura; Roman, Antonio; Moreno, Antonio; Armengol, Manuel; Solé, Juan

2018-03-10

Lung disease is the major cause of death among cystic fibrosis (CF) patients, affecting 80% of the population. The impact of extracorporeal circulation (ECC) during transplantation has not been fully clarified. This study aimed to evaluate the outcomes of lung transplantation for CF in a single center, and to assess the impact of ECC on survival. We performed a retrospective observational study of all trasplanted CF patients in a single center between 1992 and 2011. During this period, 64 lung transplantations for CF were performed. Five- and 10-year survival of trasplanted patients was 56.7% and 41.3%, respectively. Pre-transplantation supplemental oxygen requirements and non-invasive mechanical ventilation (NIMV) do not seem to affect survival (P=.44 and P=.63, respectively). Five- and 10-year survival among patients who did not undergo ECC during transplantation was 75.69% and 49.06%, respectively, while in those did undergo ECC during the procedure, 5- and 10-year survival was 34.14% and 29.87%, respectively (P=.001). PaCO 2 is an independent risk factor for the need for ECC. The survival rates of CF patients undergoing lung transplantation in our hospital are similar to those described in international registries. Survival is lower among patients receiving ECC during the procedure. PaCO 2 is a risk factor for the need for ECC during lung transplantation. Copyright © 2018 SEPAR. Publicado por Elsevier España, S.L.U. All rights reserved.

Novel Antihypertensive Prodrug from Grape Seed Proanthocyanidin Extract via Acid-Mediated Depolymerization in the Presence of Captopril: Synthesis, Process Optimization, and Metabolism in Rats.

Science.gov (United States)

Cui, Can; Shi, Ailong; Bai, Shuang; Yan, Pengyu; Li, Qing; Bi, Kaishun

2018-04-11

Grape seed extract contains a high content of proanthocyanidins that can be depolymerized into C-4-substituted (epi)catechin derivatives in the presence of nucleophiles. However, the biological and medicinal values of depolymerization products have been rarely investigated. Recently, we developed a novel depolymerization product (-)-epicatechin-4β- S-captopril methyl ester (ECC) derived from the reaction of grape seed proanthocyanidin extract with captopril in the presence of acidified methanol. A central composite design was employed to select the most appropriate depolymerization temperature and time to obtain the target product ECC with a high yield. A total of 16 metabolites of ECC in rat urine, feces, and plasma were identified using liquid chromatography quadrupole time-of-flight tandem mass spectrometry. The in vivo results suggested that ECC could release captopril methyl ester and epicatechin, followed by the generation of further metabolites captopril and epicatechin sulfate conjugates. Therefore, ECC may be used as a potential prodrug with synergistic or additive hypotensive effects.

Comparison of concentric and eccentric bench press repetitions to failure.

Science.gov (United States)

Kelly, Stephen B; Brown, Lee E; Hooker, Steven P; Swan, Pamela D; Buman, Matthew P; Alvar, Brent A; Black, Laurie E

2015-04-01

Eccentric muscle actions (ECC) are characterized by muscle lengthening, despite actin-myosin crossbridge formation. Muscles acting eccentrically are capable of producing higher levels of force compared with muscles acting concentrically. The purpose of this study was to determine whether ECC bench press yields greater strength than concentric (CON) as determined by 1 repetition maximum (1RM). Additionally, a comparison was made examining differences in the number of repetitions to failure at different relative intensities of 1RM. Thirty healthy men (age = 24.63 ± 5.6 years) were tested for 1RM in CON and ECC bench press and the number of repetitions completed at 60, 70, 80, and 90% 1RM. For CON repetitions, the weight was mechanically lowered to the chest, and the participant pressed it up until the elbows were fully extended. The ECC bench press consisted of lowering a barbell from a fully extended elbow position to the chest in a continuous controlled manner for 3 seconds as determined by electronic metronome. Paired t-tests showed that ECC 1RM (115.99 ± 31.08 kg) was significantly (p ≤ 0.05) greater than CON 1RM (93.56 ± 26.56 kg), and the number of repetitions completed at 90% 1RM was significantly (p ≤ 0.05) greater in ECC (7.67 ± 3.24) as compared with CON (4.57 ± 2.21). There were no significant differences in number of completed repetitions during CON and ECC bench press at 60, 70, and 80% 1RM. These data indicate that ECC actions yield increased force capabilities (∼120%) as compared with CON in the bench press and may be less prone to fatigue, especially at higher intensities. These differences suggest a need to develop unique strategies for training eccentrically.

WHO Global Consultation on Public Health Intervention against Early Childhood Caries.

Science.gov (United States)

Phantumvanit, Prathip; Makino, Yuka; Ogawa, Hiroshi; Rugg-Gunn, Andrew; Moynihan, Paula; Petersen, Poul Erik; Evans, Wendell; Feldens, Carlos Alberto; Lo, Edward; Khoshnevisan, Mohammad H; Baez, Ramon; Varenne, Benoit; Vichayanrat, Tippanart; Songpaisan, Yupin; Woodward, Margaret; Nakornchai, Siriruk; Ungchusak, Chantana

2018-01-30

Early Childhood Caries (ECC) is prevalent around the world, but in particular the disease is growing rapidly in low- and middle-income countries in parallel with changing diet and lifestyles. In many countries, ECC is often left untreated, a condition which leads to pain and adversely affects general health, growth and development, and quality of life of children, their families and their communities. Importantly, ECC is also a global public health burden, medically, socially and economically. In many countries, a substantial number of children require general anaesthesia for the treatment of caries in their primary teeth (usually extractions), and this has considerable cost and social implications. A WHO Global Consultation with oral health experts on "Public Health Intervention against Early Childhood Caries" was held on 26-28 January 2016 in Bangkok (Thailand) to identify public health solutions and to highlight their applicability to low- and middle-income countries. After a 3-day consultation, participants agreed on specific recommendations for further action. National health authorities should develop strategies and implement interventions aimed at preventing and controlling ECC. These should align with existing international initiatives such as the Sixtieth World Health Assembly Resolution WHA 60.17 Oral health: action plan for promotion and integrated disease prevention, WHO Guideline on Sugars and WHO breastfeeding recommendation. ECC prevention and control interventions should be integrated into existing primary healthcare systems. WHO public health principles must be considered when tackling the effect of social determinants in ECC. Initiatives aimed at modifying behaviour should focus on families and communities. The involvement of communities in health promotion, and population-directed and individual fluoride administration for the prevention and control of ECC is essential. Surveillance and research, including cost-effectiveness studies, should be

Status of Issues in U.S. Edge-Plasma Research and Priority Topics for the Next Five Years

International Nuclear Information System (INIS)

Bateman, G.; Chang, C.; Fenstermacher, M.; Guzdar, P.; Hahm, T.S.; Krasheninnikov, S.; Kritz, A.; Rognlien, T D.; Schnack, D.; Schultz, D.; Snyder, P.; Stotler, D.; Terry, J.; Ulrickson, M.; Bolton, C.

2005-01-01

The Edge Coordinating Committee (ECC) was formed in July 14-15, 2004 when OFES Theory Team invited 14 plasma researchers to a two-day meeting in Germantown, MD to discuss the state of edge-plasma research in the U.S. with a focus on theory and modeling (see http://www.mfescience.org/ecc/ ecc/). At that time, OFES tasked the ECC with providing, in about a six month period, a report on the present status of key issues in this area together with a roadmap of what range of activities should be undertaken in the next five years to resolve these issues. This document is a response to that charge. Future edge-plasma research described here is assumed to fit into a budget constraint of a ''flat budget,'' with some additional activities cited for budget increases of as much as 50%. To obtain some measure of the relative fraction of OFES Theory funding presently devoted to edge plasma research, the OFES Theory Team informally surveyed funded work they support in this area at National Labs, Universities, and industry. John Mandrekas reported to us that approximately 10% of the present budget goes to edge-physics areas at 10 institutions, for a total of ∼$2.5M each year. While not explicitly estimated, we note that there are also important edge plasma projects in the Plasma Technology program, especially related to plasma/material sputtering interactions, near-surface plasma chemistry and transport, and impurity transport. Likewise, the Confinement Program has important efforts in interpreting edge-plasma data through modeling codes. This initial status/roadmap work of the ECC is complimentary to the Fusion Energy Science Sciences Advisory Committee (FESAC) Panel on Program Priorities (see http://www.mfescience.org/fesac/ fesac/). This Panel is charged with identifying major science and technology issues for all of controlled fusion and also with recommending campaigns to address these issues. The Panel has organized their report along six thematic areas, one of which

Parâmetros reprodutivo e metabólico de vacas da raça Guzerá suplementadas no pré e pós-parto Reproductive and metabolic parameters of Guzerá cows supplemented in pre and postpartum

Directory of Open Access Journals (Sweden)

Marcelo Marcondes de Godoy

2004-02-01

Full Text Available Foram utilizadas 30 vacas da raça Guzerá (10 por tratamento, suplementadas no pré-parto (PRE, pós-parto (POS e sem suplementação (SS com os objetivos de avaliar no pós-parto as variações do peso corporal (PC, do escore de condição corporal (ECC (1 = muito magra a 9 = muito gorda e dos níveis plasmáticos de colesterol total (NPCT, o índice de prenhez (IP até 112 dias pós-parto e a viabilidade econômica dos tratamentos PRE e POS, que constou de 1 kg/dia/animal de concentrado (16% PB; 3000 kcal ED/kg. O PC e o ECC foram obtidos a cada 28 dias, e colheitas de sangue semanalmente para análise dos NPCT até 112 dias pós-parto. O PC e o ECC tiveram interação dias pós-parto x tratamento. O tratamento PRE aumentou o PC e o ECC das vacas ao parto: 477,80 kg e 6,20 respectivamente, em comparação com os tratamentos POS e SS de 453,37 kg e 5,5; 447,57 kg e 5,28, respectivamente. O PC e o ECC do tratamento PRE foi superior de 28 a 84 dias comparado ao SS, enquanto o tratamento POS foi superior apenas de 84 a 112 dias pós-parto. O tratamento POS não diferiu do PRE no PC de 56 a 112 dias pós-parto e no ECC de 28 a 112 dias pós-parto. O tratamento POS proporcionou aumento do PC e ECC das vacas, já os tratamentos PRE e SS perderam PC e ECC até 112 dias pós-parto. O PC e ECC dos tratamentos PRE, POS e SS aos 112 dias pós-parto foram de 457,79 kg e 5,38; 461,87 kg e 5,66; 436,57 kg e 4,78, respectivamente. Os NPCT tiveram efeito dos dias pós-parto, mas não de tratamento, aumentando com os dias pós-parto. Os IP não foram influenciados pelos tratamentos PRE, POS e SS com 50,00; 62,20 e 57,14%, respectivamente. Economicamente a suplementação não foi viável.Thirty Guzera cows (10 by treatment, supplemented in the prepartum (PRE and postpartum (POS and without supplementation (SS were used to evaluate, in the postpartum, the variation of body weight (BW, body condition score (BCS (1 = very thin to 9 = very fat and levels of serum

Electron capture to the continuum from atomic hydrogen

International Nuclear Information System (INIS)

Glass, G.A.; Engar, P.; Berry, S.D.; Breinig, M.; Deserio, R.; Elston, S.B.; Sellin, I.A.

1984-01-01

The first known measurement of the differential cross section for electron capture to the continuum(ECC) from atomic hydrogen is presented. A 12 MeV beam of C 6+ ions traversed a static target of atomic hydrogen produced by an electron impact heated dissociation oven. The resulting ECC spectrum was obtained with a channel electron multiplier detector mounted at the exit of a 160 0 spherical sector electrostatic spectrometer with an angular acceptance of 2 0 . The ECC spectrum clearly shows the asymmetry generally associated with ECC spectra from gaseous targets. The ratio of the singly differential cross section of H to that of H 2 was found to be 0.80. 16 references, 3 figures

14 CFR 27.977 - Fuel tank outlet.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fuel tank outlet. 27.977 Section 27.977... STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Fuel System § 27.977 Fuel tank outlet. (a) There must be a fuel stainer for the fuel tank outlet or for the booster pump. This strainer must— (1) For...

Managing Early Childhood Caries for Young Children in China

Directory of Open Access Journals (Sweden)

Kitty Jieyi Chen

2018-01-01

Full Text Available The latest national survey found that 70% of 5-year-old children in China had dental caries. The prevalence of early childhood caries (ECC may not only be attributed to poor oral hygiene and unhealthy diet, but also to limited access to and availability of dental care. The prevailing preventive measures adopted by industrialised countries for ECC management are neither practical nor affordable in China. Hence, an alternative approach to ECC management is necessary. Atraumatic restorative treatment (ART has been advocated because the simple and short operative time renders ART affordable. However, the success rate of ART in restoring anterior primary teeth is unfavourable. Although there is no water fluoridation in China, topical fluorides may be used to manage ECC. Tooth brushing with fluoride toothpaste is effective for caries control, but not all toothpastes in China are fluoridated. Professionally applied fluorides such as sodium fluoride varnish can be a cost-effective treatment for managing the high prevalence of ECC in China. Silver diamine fluoride (SDF at 38% is suggested to be effective in arresting ECC in China. It can be a simple, non-invasive and low-cost treatment. However, it stains caries black. Children and their parents must be well informed before SDF treatment.

Pre design processing of waste of ex-resin without materials matrix from nuclear power plant type PWR 1000 MW

International Nuclear Information System (INIS)

Cerdas Tarigan

2010-01-01

Have been done pre design processing of waste ex-resin without capacities matrix materials from nuclear power plant type PWR 1000 MW During the time radioactive waste of ex-resin processed to use process of immobilization use matrix materials like mixture cement and epoxy resin and then conditioning. This process is not effective and efficient because end result volume of end product bigger than volume early operation system and maintenance of its installation more difficult. To overcome this created a design of technology processing of waste of ex- resin without matrix materials through process of strainer, drying and conditioning represent technological innovation newly processing of radioactive waste of ex-resin. Besides this process more effective and efficient, volume of end product waste much more small from volume early and operation system and maintenance of its easier installation. Pre design is expected to be used as a basis to make conceptual of pre design installation of strainer, drying and conditioning for the processing of waste of ex-resin from nuclear power plant type PWR 1000 MW. (author)

Weigh Station and Grid Plate Testing

International Nuclear Information System (INIS)

PAJUNEN, A.L.

2000-01-01

The purpose of this test is to verify that the Shortened Fuel Canister Hook with Certified Scale (i.e. Weigh Station) can be used to weigh an empty canister from the Canister Well and the empty Primary Cleaning Machine (PCM) Strainer Basket from the process table. Drawing H-1-84835, ''Canister Handling Hook for Fuel Retrieval System Process Table,'' provides details of the Shortened Fuel Canister Hook. It is also necessary to verify that the grid plate can be lifted and tilted over a canister in the canister well. This testing shall be performed before N Reactor fuel is processed through the FRS in Phase 3. The Phase 3 Test will repeatedly weigh fuel and scrap canisters and the PCM strainer basket containing N Reactor fuel (Pajunen, et. al, 2000). Advance testing of this weigh station will ensure that accurate fuel weight data can be recorded in the Phase 3 Test. This document satisfies the requirements EN-6-031-00, ''Testing Process'' for a test plan, test specification and test procedure

Nitric oxide : An ally in extracorporeal circulation?

OpenAIRE

Melki, Vilyam

2016-01-01

Many complications associated with heart surgery are due to the negative effects of extracorporeal circulation (ECC). Some of these complications may be attributed to ECC-induced activation of inflammation and coagulation pathways. The inflammatory reaction may be caused by the interaction of blood components with air and the artificial surfaces of the ECC, from substances produced due to ischaemia-reperfusion injury of the heart and lungs, and from increased release of endotoxin from ischemi...

Within and between population variation in epidermal club cell investment in a freshwater prey fish: a cautionary tale for evolutionary ecologists.

Directory of Open Access Journals (Sweden)

Aditya K Manek

Full Text Available Many prey fishes possess large club cells in their epidermis. The role of these cells has garnered considerable attention from evolutionary ecologists. These cells likely form part of the innate immune system of fishes, however, they also have an alarm function, releasing chemical cues that serve to warn nearby conspecifics of danger. Experiments aimed at understanding the selection pressures leading to the evolution of these cells have been hampered by a surprisingly large intraspecific variation in epidermal club cell (ECC investment. The goal of our current work was to explore the magnitude and nature of this variation in ECC investment. In a field survey, we documented large differences in ECC investment both within and between several populations of minnows. We then tested whether we could experimentally reduce variation in mean ECC number by raising fish under standard laboratory conditions for 4 weeks. Fish from different populations responded very differently to being held under standard laboratory conditions; some populations showed an increase in ECC investment while others remained unchanged. More importantly, we found some evidence that we could reduce within population variation in ECC investment through time, but could not reduce among-population variation in mean ECC investment. Given the large variation we observed in wild fish and our limited ability to converge mean cell number by holding the fish under standard conditions, we caution that future studies may be hard pressed to find subtle effects of various experimental manipulations; this will make elucidating the selection pressures leading to the evolution of the cells challenging.

Quantification of Operational Learning in Minimal Invasive Extracorporeal Circulation.

Science.gov (United States)

Anastasiadis, Kyriakos; Antonitsis, Polychronis; Asteriou, Christos; Argiriadou, Helena; Deliopoulos, Apostolos; Konstantinou, Dimitrios; Grosomanidis, Vassilios; Tossios, Paschalis

2017-07-01

Minimal invasive extracorporeal circulation (MiECC) has initiated important new efforts within science and technology towards a more physiologic perfusion. In this study, we aim to investigate the learning curve of our center regarding MiECC. We studied a series of 150 consecutive patients who underwent elective coronary artery bypass grafting by the same surgical team during the initial phase of MiECC application. Patients were randomly assigned into two groups. Group A (n = 75) included patients operated on MiECC, while group B (n = 75) included patients operated with conventional cardiopulmonary bypass (cCPB). The primary end-point of the study was to identify whether there is a learning curve when operating on MiECC. The following parameters were unrelated with increasing experience, even though the results favored MiECC use: reduced CPB duration (102.9 ± 25 vs. 122.2 ± 33 min, P learning applied to postoperative hematocrit and hemoglobin levels (R 2  = 0.098, P = 0.006). We identified that advantages of MiECC technology in terms of reduced hemodilution and improved end-organ protection and clinical outcome are evident from the first patient. Optimal results are obtained with 50 cases; this refers mainly to significant reduction in the need for intraoperative blood transfusion. Teamwork from surgeons, anesthesiologists, and perfusionists is of paramount importance in order to maximize the clinical benefits from this technology. © 2016 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

Flexibility training and the repeated-bout effect: priming interventions prior to eccentric training of the knee flexors.

Science.gov (United States)

Leslie, Andrew W; Lanovaz, Joel L; Andrushko, Justin W; Farthing, Jonathan P

2017-10-01

Both the repeated-bout effect and increased flexibility have been linked to reduced muscle damage, fatigue, and strength loss after intense eccentric exercise. Our purpose was to compare the eccentric-training (ECC) response after first priming the muscles with either static flexibility training or a single intense bout of eccentric exercise. Twenty-five participants were randomly assigned to flexibility training (n = 8; 3×/week; 30 min/day), a single bout of intense eccentric exercise (n = 9), or no intervention (control; n = 8) during a 4-week priming phase, prior to completing a subsequent 4-week period of eccentric training of the knee flexors. Testing was completed prior to the priming phase, before ECC, during acute ECC (0 h, 24 h, and 48 h after bouts 1 and 4), and after ECC. Measures included muscle thickness (MT; via ultrasound); isometric, concentric, and eccentric strength; muscle power (dynamometer); electromyography; range of motion; optimal angle of peak torque; and soreness (visual analog scale). Flexibility training and single-bout groups had 47% less soreness at 48 h after the first bout of ECC compared with control (p training group had 10% less soreness at 48 h after the fourth ECC bout compared with both the single-bout and control groups (p training group (-9%) after the fourth ECC bout compared with control (-19%; p training may be more effective than a single session of eccentric exercise in reducing adverse symptoms during the acute stages of eccentric training; however, these benefits did not translate into greater performance after training.

Quantitative assessment of salivary oral bacteria according to the severity of dental caries in childhood.

Science.gov (United States)

Colombo, Natália H; Kreling, Paula F; Ribas, Laís F F; Pereira, Jesse A; Kressirer, Christine A; Klein, Marlise I; Tanner, Anne C R; Duque, Cristiane

2017-11-01

This study aimed to assess differences in selected oral bacteria in children according to the severity of dental caries. One hundred and thirty-six children, 36-60 months old were divided into three groups according to caries status: caries-free (CF) (n=47), early childhood caries (ECC) (n=40) and severe-early childhood caries (S-ECC) (n=49). Saliva was collected for detection and quantification of selected oral streptococci, Actinomyces naeslundii, Lactobacillus spp., Bifidobacterium spp., and Scardovia wiggsiae by quantitative-polymerase chain reaction. The results showed that the detection and quantitative levels of S. mutans, S. sobrinus, Bifidobacterium spp. and S. wiggsiae were significantly higher in S-ECC children compared to CF and ECC children, while for S. salivarius were significantly higher in CF compared to ECC and S-ECC children. There was no statistical difference among the clinical groups for S. mitis, S. oralis, A. naeslundii and Lactobacillus spp. levels and detection. S-ECC children had a lower monthly family income, started tooth brushing later and were breastfeed for a longer duration compared to CF children. S. mutans levels were positively correlated with S. wiggsiae and Bifidobacterium spp. levels, lower mother's education and child bottle-feeding before sleeping and negatively correlated with S. salivarius. It was concluded that in addition to S. mutans, other bacterial species, including bifidobacteria, Scardovia wiggsiae and S. sobrinus, are associated with severity of early childhood caries, although their role in the progress of dental caries remains unclear. Copyright © 2017 Elsevier Ltd. All rights reserved.

Evaluating the impact of a community developed collaborative project for the prevention of early childhood caries: the Healthy Smile Happy Child project.

Science.gov (United States)

Schroth, Robert J; Edwards, Jeanette M; Brothwell, Douglas J; Yakiwchuk, Carol A; Bertone, Mary F; Mellon, Bernadette; Ward, Jennifer; Ellis, Marion; Hai-Santiago, Khalida; Lawrence, Herenia P; Moffatt, Michael E

2015-01-01

To determine the effectiveness of the Healthy Smile Happy Child (HSHC) project, a community-developed initiative promoting early childhood oral health in Manitoba, Canada. Specific aims were to assess improvements in caregiver knowledge, attitudes, and behaviours relating to early childhood oral health, and the burden of early childhood caries (ECC) and severe ECC (S-ECC). A serial cross-sectional study design was selected to contrast findings following the Healthy Smile Happy Child (HSHC) campaign in four communities with the previous baseline data. One community was a remote First Nation in northern Manitoba and another was a rural First Nation in southern Manitoba. The other two communities were urban centres, one of which was located in northern Manitoba. A community-development approach was adopted for the project to foster community solutions to address ECC. Goals of the HSHC program were to promote the project in each community, use existing community-based programs and services to deliver the oral health promotion and ECC prevention activities, and recruit and train natural leaders to assist in program development and to deliver the ECC prevention program. The HSHC coordinator worked with communities to develop a comprehensive list of potential strategies to address ECC. Numerous activities occurred in each community to engage members and increase their knowledge of early childhood oral health and ultimately lead them to adopt preventive oral health practices for their young children. Children under 71 months of age and their primary caregivers participated in this follow-up study. A -value ≤0.05 was statistically significant. 319 children (mean age 38.2±18.6 months) and their primary caregivers participated. Significant improvements in caregiver knowledge and attitudes were observed following the HSHC campaign, including that baby teeth are important (98.8%), that decay involving primary teeth can impact on health (94.3%), and the importance of a dental

Key technology for treating slack coal blockage in CBM recovery: A case study from multi-lateral horizontal wells in the Qinshui Basin

Directory of Open Access Journals (Sweden)

Yong Yang

2016-01-01

Full Text Available Due to the nature of coal bed, slack coal production is inevitable in gas recovery sby water drainage. When coalbed methane (CBM wells are reentered after low energy exploitation and shut-in, the negative effect of slack coal production on productivity of CBM is irreversible. In this paper, the CBM occurrence characteristics and multi-lateral horizontal well trajectory in the Qinshui Basin, Shanxi Province, were analyzed. In the multi-lateral horizontal wells, the expected gas production rate could not be reached and the production rate after shut-in maintenance could not restore to the level before shut-in. The reason for these issues is that migration pathways in the reservoirs are blocked by slack coal deposits, while formation water and slack coal deposit accumulated at the troughs of horizontal sections enlarge the resistance for gas to flow into the bottom hole. Furthermore, three key technologies to deal with slack coal blockage were proposed. Firstly, CBM horizontal well trajectory should follow the principle of keeping the wellbores smooth and updip instead of being “wavy”, on the premise of guaranteeing CBM drilling rate. Secondly, the cavities of production wells, as an important part of multi-lateral horizontal wells, are capable of settling sand, and can be used for gas–liquid–solid separation. And thirdly, a tree-like horizontal well with its main hole set on stable seam top or floor, provides a stable well flushing passage for coal powder. This research provides a useful attempt in solving the problem of slack coal production in gas recovery by water drainage.

33 CFR 183.590 - Fire test.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Fire test. 183.590 Section 183... SAFETY BOATS AND ASSOCIATED EQUIPMENT Fuel Systems Tests § 183.590 Fire test. (a) A piece of equipment is... A2” hoses and hose clamps are tested in a fire chamber. (2) Fuel filters, strainers, and pumps are...

J.P. Marais,* D.L. Figenschou and G.A.J. Woodley Kikuyu grass ...

African Journals Online (AJOL)

6,5 h after the first daily feeding, using the suction strainer technique of Raun & Burroughs (1962). Rumen fluid samples were analysed for ammonia and the mean value of the three samples was taken as a measure of the overall rumen ammonia content. During the next four days of the collection period, the grass intake ...

Highly accurate fluorogenic DNA sequencing with information theory-based error correction.

Science.gov (United States)

Chen, Zitian; Zhou, Wenxiong; Qiao, Shuo; Kang, Li; Duan, Haifeng; Xie, X Sunney; Huang, Yanyi

2017-12-01

Eliminating errors in next-generation DNA sequencing has proved challenging. Here we present error-correction code (ECC) sequencing, a method to greatly improve sequencing accuracy by combining fluorogenic sequencing-by-synthesis (SBS) with an information theory-based error-correction algorithm. ECC embeds redundancy in sequencing reads by creating three orthogonal degenerate sequences, generated by alternate dual-base reactions. This is similar to encoding and decoding strategies that have proved effective in detecting and correcting errors in information communication and storage. We show that, when combined with a fluorogenic SBS chemistry with raw accuracy of 98.1%, ECC sequencing provides single-end, error-free sequences up to 200 bp. ECC approaches should enable accurate identification of extremely rare genomic variations in various applications in biology and medicine.

The effect of different accentuated eccentric load levels in eccentric-concentric loading contractions on acute neuromuscular, growth hormone and blood lactate responses during a hypertrophic protocol

OpenAIRE

Ojasto, Timo

2007-01-01

When accentuated load is applied during the eccentric (ECC) phase of eccentric-concentric (ECC-CON) contractions, it is defined as dynamic accentuated external resistance (DAER) exercise. This study monitored acute neuromuscular responses, growth hormone (GH) and blood lactate (La) concentrations to find out the most efficient ECC-CON loading strategy for muscle hypertrophy by employing various DAER resistances in the bench-press. Male subjects (age=32.4±4.3years, n=11) were assigned as subje...

Nutrient accumulation and biomass production of alfafa after soil amendment with silicates

Directory of Open Access Journals (Sweden)

Angélica Cristina Fernandes Deus

2014-06-01

Full Text Available Studies on the use of silicate correctives in agriculture show that they have great potential to improve soil chemical characteristics, however, little information is available on the reactivity rates of their particle-size fractions. This study investigated whether the reactivity rates obtained experimentally could be considered in the calculation of ECC (effective calcium carbonate for soil liming, promoting adequate development of alfalfa plants. Six treatments were evaluated in the experiment, consisting of two slag types applied in two rates. The experimental ECC was used to calculate one of the rates and the ECC determined in the laboratory was used to calculate the other. Rates of limestone and wollastonite were based on the ECC determined in laboratory. The rates of each soil acidity corretive were calculated to increase the base saturation to 80%. The treatments were applied to a Rhodic Hapludox and an Alfisol Ferrudalfs. The methods for ECC determination established for lime can be applied to steel slag. The application of slag corrected soil acidity with consequent accumulation of Ca, P, and Si in alfalfa, favoring DM production.

Different Muscle Action Training Protocols on Quadriceps-Hamstrings Neuromuscular Adaptations.

Science.gov (United States)

Ruas, Cassio V; Brown, Lee E; Lima, Camila D; Gregory Haff, G; Pinto, Ronei S

2018-05-01

The aim of this study was to compare three specific concentric and eccentric muscle action training protocols on quadriceps-hamstrings neuromuscular adaptations. Forty male volunteers performed 6 weeks of training (two sessions/week) of their dominant and non-dominant legs on an isokinetic dynamometer. They were randomly assigned to one of four groups; concentric quadriceps and concentric hamstrings (CON/CON, n=10), eccentric quadriceps and eccentric hamstrings (ECC/ECC, n=10), concentric quadriceps and eccentric hamstrings (CON/ECC, n=10), or no training (CTRL, n=10). Intensity of training was increased every week by decreasing the angular velocity for concentric and increasing it for eccentric groups in 30°/s increments. Volume of training was increased by adding one set every week. Dominant leg quadriceps and hamstrings muscle thickness, muscle quality, muscle activation, muscle coactivation, and electromechanical delay were tested before and after training. Results revealed that all training groups similarly increased MT of quadriceps and hamstrings compared to control (p0.05). These findings suggest that different short-term muscle action isokinetic training protocols elicit similar muscle size increases in hamstrings and quadriceps, but not for other neuromuscular variables. Nevertheless, effect sizes indicate that CON/ECC and ECC/ECC may elicit the greatest magnitude of change in muscle hypertrophy. © Georg Thieme Verlag KG Stuttgart · New York.

Countermovement jump height: gender and sport-specific differences in the force-time variables.

Science.gov (United States)

Laffaye, Guillaume; Wagner, Phillip P; Tombleson, Tom I L

2014-04-01

The goal of this study was to assess (a) the eccentric rate of force development, the concentric force, and selected time variables on vertical performance during countermovement jump, (b) the existence of gender differences in these variables, and (c) the sport-specific differences. The sample was composed of 189 males and 84 females, all elite athletes involved in college and professional sports (primarily football, basketball, baseball, and volleyball). The subjects performed a series of 6 countermovement jumps on a force plate (500 Hz). Average eccentric rate of force development (ECC-RFD), total time (TIME), eccentric time (ECC-T), Ratio between eccentric and total time (ECC-T:T) and average force (CON-F) were extracted from force-time curves and the vertical jumping performance, measured by impulse momentum. Results show that CON-F (r = 0.57; p differ between both sexes (p differ, showing a similar temporal structure. The best way to jump high is to increase CON-F and ECC-RFD thus minimizing the ECC-T. Principal component analysis (PCA) accounted for 76.8% of the JH variance and revealed that JH is predicted by a temporal and a force component. Furthermore, the PCA comparison made among athletes revealed sport-specific signatures: volleyball players revealed a temporal-prevailing profile, a weak-force with large ECC-T:T for basketball players and explosive and powerful profiles for football and baseball players.

Validation of an early childhood caries risk assessment tool in a low-income Hispanic population.

Science.gov (United States)

Custodio-Lumsden, Christie L; Wolf, Randi L; Contento, Isobel R; Basch, Charles E; Zybert, Patricia A; Koch, Pamela A; Edelstein, Burton L

2016-03-01

There is a recognized need for valid risk assessment tools for use by both dental and nondental personnel to identify young children at risk for, or with, precavitated stages of early childhood caries (i.e., early stage decalcifications or white spot lesions).The aim of this study is to establish concurrent criterion validity of "MySmileBuddy" (MSB), a novel technology-assisted ECC risk assessment and behavioral intervention tool against four measures of ECC activity: semi-quantitative assays of salivary mutans streptococci levels, visible quantity of dental plaque, visual evidence of enamel decalcifications, and cavitation status (none, ECC, severe ECC). One hundred eight children 2-6 years of age presenting to a pediatric dental clinic were recruited from a predominantly Spanish-speaking, low-income, urban population. All children received a comprehensive oral examination and saliva culture for assessment of ECC indicators. Their caregivers completed the iPad-based MSB assessment in its entirety (15-20 minutes). MSB calculated both diet and comprehensive ECC risk scores. Associations between all variables were determined using ordinal logistic regression. MSB diet risk scores were significantly positively associated with salivary mutans (P valid risk assessment tool for identifying children with early precursors of cavitations but does not add value in identifying children with extant lesions. © 2015 American Association of Public Health Dentistry.

Early childhood caries in preschool children of Kosovo - a serious public health problem

Directory of Open Access Journals (Sweden)

Meqa Kastriot

2010-12-01

Full Text Available Abstract Background Even though it has been widely studied, early childhood caries (ECC remains a serious public health problem, especially in countries where there is no national program of oral health assessment and no genuine primary oral health care, such as in Kosovo. The purpose of this study was to assess the prevalence of ECC and analyze caries risk factors. Methods The subjects were 1,008 preschool children, selected by stratified random cluster sampling, in the municipality of Prishtina, capital of Kosovo. Data were collected through clinical examination and interviews. Dmft data were recorded according to WHO criteria. Bacterial examination (CRT bacteria test and plaque test of Greene-Vermillion were used. Results The mean dmft of preschool children was found to be 5.8. The prevalence of ECC was 17.36%, with a mean dmft of 11 ± 3.6. Streptococcus mutans prevalence in ECC children was 98%. A significant correlation between dmft and S mutans counts (≥105 CFU/mL saliva was demonstrated. A correlation was also found between daily sweets consumption and dmft in children with ECC (P P Conclusion The prevalence of ECC was high among preschool children in the municipality of Kosovo. We recommend increasing parents' knowledge of proper feeding habits and oral health practices, and increasing preschool children's accessibility to dental services.

The Association between Cariogenic Factors and the Occurrence of Early Childhood Caries in Children from Salem District of India.

Science.gov (United States)

Stephen, Arokiaraj; Krishnan, Ramesh; Chalakkal, Paul

2017-07-01

Various aetiological factors for Early Childhood Caries (ECC) have been suggested in literature, but the role of each factor has been disputed in various studies. To evaluate the association between ECC and its related factors in children between three to six years of age, from rural, semi-urban and urban schools in the district of Salem (India). The study consisted of children between three to six years of age, selected randomly from schools in semi-urban, urban and rural schools at Salem. Questionnaire (comprising of the factors associated with ECC) and parental consent forms were sent to each of the parents of the school children. Filled questionnaires and parental consent forms were obtained from a total of 2771 children, out of which 1771 were boys and 1000 were girls. Clinical examination for ECC was carried out according to the WHO criteria, by a single examiner and an assistant to eliminate inter-examiner variability. Statistical analysis was carried out using the student's independent t-test and ANOVA (one way analysis of variance). Out of a total of 2771 children examined, only 443 (315 boys and 128 girls) children were found to have ECC (16 %). Significant correlations were found between the occurrence of ECC and various factors like age of parents, number of siblings, on-demand breast feeding and bottle feeding habits and sweetened pacifier use. However, factors such as age and gender of the child, type of birth and duration of pregnancy, had no significant correlation with the occurrence of ECC. The need for educating parents on the ill effects of improper breast feeding and bottle feeding habits is important.

Impact of early childhood caries and its treatment under general anesthesia on orofacial function and quality of life : A prospective comparative study.

Science.gov (United States)

Collado, V; Pichot, H; Delfosse, C; Eschevins, C; Nicolas, E; Hennequin, M

2017-05-01

Early Childhood Caries (ECC) has become a major public health concern worldwide, mostly affecting children from disadvantaged families in increasingly severe forms. This condition has been frequently reported to alter children's nutrition, growth and general development. It negatively impacts their quality of life, through painful episodes and severe eating difficulties. While this period is crucial for oral praxes development, the impact of dental state on oro-facial functions is poorly documented. This study evaluated the impact of ECC and its treatment under general anesthesia on oro-facial functions and quality of life in pre-school children. The dysfunction and quality of life scores from 25 children with ECC were evaluated before treatment (T0), one month (T1) and three months after treatment (T2), using the Nordic Orofacial Test-Screening (NOT-S) and the Early Childhood Oral Health Impact Scale (ECOHIS), respectively, in comparison with 16 caries-free children. The number and extent of inter-arch dental contacts were also observed. The pre-operative higher NOT-S score observed in children with ECC decreased to reach the control level at T2. The mastication item was the most affected in the ECC group throughout the study. Their mean ECOHIS score also significantly decreased post-operatively and differences remaining between both groups were no longer clinically relevant. In addition, in children with ECC, values of functional inter-arch surfaces tended to increase over the follow-up period. Oro-facial functions and quality of life, altered by ECC, could be restored through a conservative treatment approach. Relations between dental state, orofacial functions and particularly chewing, and nutrition should be investigated further.

Effect of alpha amylase on early childhood caries: a matched case-control study

OpenAIRE

Mojarad, Farzad; Department of Pediatric Dentistry, School of Dentistry, Hamadan University of Medical Sciences, Hamadan; Fazlollahifar, Samira; Department of Pediatric Dentistry, School of Dentistry, Hamadan University of Medical Sciences, Hamadan; Poorolajal, Jalal; Research Center for Health Sciences, Department of Epidemiology & Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan; Hajilooi, Mehrdad; Department of Pathology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan

2013-01-01

Objectives: There are a few studies addressing the relationship between salivary alpha-amylase and dental caries. This study was implemented in order to investigate the effect of salivary alpha-amylase level on early childhood caries (ECC).Materials and Methods: In this matched case-control study, which was carried out from November 2011 to March 2012 in Hamadan City, the west of Iran, mean levels of salivary alpha-amylase of 84 ECC-active cases were compared to that of 84 ECC-free controls u...

Prevalence and risk factors of caregiver reported Severe Early Childhood Caries in Manitoba First Nations children: results from the RHS Phase 2 (2008–2010

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Robert J. Schroth

2013-08-01

Full Text Available Objectives. The high prevalence and severity of caries among Canadian First Nations children is a growing concern. Dental surgery in hospital is often necessary to treat the signs of decay but does not address the underlying factors contributing to its development. The purpose of this study was to determine the prevalence and risk factors of caregiver-reported Baby Bottle Tooth Decay (BBTD, or Severe Early Childhood Caries (S-ECC, among preschool children recruited in Phase 2 of the First Nations Regional Longitudinal Health Survey (RHS. Study Design. Cross-sectional study including interviews with caregivers. Methods. This study was limited to data from Manitoba First Nations participating in the RHS Phase 2 (2008–10. Data were restricted to caregiver interviews for their child <72 months of age. The main variable of interest was caregiver-reported BBTD, an antecedent term for S-ECC. Data analysis included descriptive statistics and bivariate analyses; p≤0.05 was significant. Results. Overall, caregivers of 431 preschool children responded. According to caregiver reports, 102/410 (24.9% children had S-ECC. Further, 65.0% responded that their child had already undergone treatment for caries. Children with S-ECC were significantly older than those without. S-ECC was also associated with paternal education levels and employment status, and maternal smoking during pregnancy. Breastfed children were less likely to have S-ECC, while consuming drink crystal beverages in bottles, and daily intake of soft drinks, juice, sweets and fast food were associated with increased risk. Those who reported that healthcare services were not available and were not culturally appropriate were significantly more likely to have children with S-ECC. Conclusions. Caregiver reports suggest that nearly 1 in every 4 children has been affected by S-ECC. Identified risk factors for Manitoba First Nations children included age, education and employment, dietary practices

ROSA-III 200% double-ended break integral test RUN 901

International Nuclear Information System (INIS)

Nakamura, Hideo; Tasaka, Kanji; Koizumi, Yasuo; Anoda, Yoshinari; Kumamaru, Hiroshige; Murata, Hideo; Suzuki, Mitsuhiro; Shiba, Masayoshi

1984-02-01

This report presents the experimental data of RUN 901, a 200% double-ended break test at the recirculation pump suction line with the ROSA-III test facility. The ROSA-III test facility is a volumetrically scaled (1/424) system of the BWR/6. The facility has the electrically heated core, the break simulator and the scaled ECCS (Emergency Core Cooling System). The MSIV closure and the ECCS actuation were tripped by the liquid level in the upper downcomer. The channel inlet flows were measured by differential pressure transducers installed at the channel inlet orifices of the fuel assembly No.4. The PCT (Peak Cladding Temperature) was 780 K occured during the blowdown phase in RUN 901. The whole core was quenched after the ECCS actuation and the effectiveness of ECCS has been confirmed. (author)

Best estimate small break LOCA analysis for KNGR SIS optimization

International Nuclear Information System (INIS)

Song, JIn Ho; Lim, Hong Sik; Bae, Kyoo Hwan; Lee, Joon

1996-01-01

The KNGR has an advanced ECCS design feature which employs four mechanically-separated SI trains where each train consisting of one HPSI pump and one SIT injects ECC water directly into the reactor vessel downcomer annulus. To demonstrate that the KNGR ECCS design features meet the EPRI ALWR requirements of no core uncovery for a break of up to 6 inch diameter, small break LOCA cases with various break sizes were analyzed using a best-estimate analytical procedure. Two kinds of break locations are considered: cold leg and DVI line breaks. It was observed that the KNGR ECCS design can tolerate a cold leg break of up to 10 inches with no core uncovery. However, since DVI line break with 6 inch diameter undergoes slight core uncovery, further investigation is required for KNGR SIS optimization

Progress in Early Childhood Caries and Opportunities in Research, Policy, and Clinical Management

DEFF Research Database (Denmark)

Garcia, Raul; Borrelli, Belinda; Dhar, Vineet

2015-01-01

The 2014 Early Childhood Caries Conference encompassed evidence-based reviews on the state of the science regarding early childhood carries (ECC) epidemiology, etiology, prevention, and disease management. The purpose of this paper was to discuss the work presented at the conference and identify...... means to prevent and manage ECC. Analyses of studies indicate that some approaches, such as chlorhexidine, iodine, and remineralizing agents, have not shown consistent findings in preventing ECC. However, evidence exists to yield recommendations in some areas. There are useful risk assessment indicators...... opportunities in research, policy, and clinical management that may improve early childhood caries outcomes and lower costs of care. While great progress has been made since the 1997 ECC Conference, there remains a paucity of high-quality evidence from randomized controlled trials on what are the most effective...

Pressure tube type reactors

International Nuclear Information System (INIS)

Komada, Masaoki.

1981-01-01

Purpose: To increase the safety of pressure tube type reactors by providing an additional ECCS system to an ordinary ECCS system and injecting heavy water in the reactor core tank into pressure tubes upon fractures of the tubes. Constitution: Upon fractures of pressure tubes, reduction of the pressure in the fractured tubes to the atmospheric pressure in confirmed and the electromagnetic valve is operated to completely isolate the pressure tubes from the fractured portion. Then, the heavy water in the reactor core tank flows into and spontaneously recycles through the pressure tubes to cool the fuels in the tube to prevent their meltdown. By additionally providing the separate ECCS system to the ordinary ECCS system, fuels can be cooled upon loss of coolant accidents to improve the safety of the reactors. (Moriyama, K.)

Innovation in pediatric clinical education: application of the essential competencies.

Science.gov (United States)

Kenyon, Lisa K; Birkmeier, Marisa; Anderson, Deborah K; Martin, Kathy

2015-01-01

At the Section on Pediatrics Education Summit in July 2012, consensus was achieved on 5 essential core competencies (ECCs) that represent a knowledge base essential to all graduates of professional physical therapist education programs. This article offers suggestions for how clinical instructors (CIs) might use the ECCs to identify student needs and guide student learning during a pediatric clinical education experience. Pediatric CIs potentially might choose to use the ECCs as a reference tool in clinical education to help (1) organize and develop general, clinic-specific clinical education objectives, (2) develop and plan individualized student learning experiences, (3) identify student needs, and (4) show progression of student learning from beginner to intermediate to entry level. The ECCs may offer CIs insights into the role of pediatric clinical education in professional physical therapist education.

Experimental investigation of debris effects on pump operation and comparison with existing wear models

International Nuclear Information System (INIS)

Lewis, D.

2010-01-01

During a Loss of Coolant Accident (LOCA) the emergency core cooling system (ECCS), comprised of several pumping systems, must provide cooling water to the reactor core. Initially, during an LOCA pumps are operated with clean water delivered from the storage tanks. After a certain time the water is recycled from the containment sump through the ECCS. This recycled water contains debris, both particulate and fibrous, that has collected in the containment sumps and passed through the strainers. The debris passing through the pumps will affect the pump performance. Previous tests, considering the effect of pumping debris, produced a model for predicting the wear in the pumps. This article and the objective of recent testing provide additional data which will improve prediction methods for performance degradation as a result of pumping foreign material. Experiments were performed on a small two stage pump with back to back impellers and a central bushing to obtain data and facilitate qualification of other pumps for these injections services. Various material combinations for pump internals, particle sizes and particle concentrations from 100 to 10000 ppm were examined. A total of six tests with more than 360 hours of run time were performed. At various points during each test, the pump was opened and dimensional measurements were taken. Pump hydraulic performance was measured during each segment of the various tests. Samples of the fluid were also taken at various times during the testing. The pump successfully ran without seizing during all modes of operation for all runs. Other incidents did occur including multiple failures involving wear through piping during the 10000 ppm run at which time the test was stopped before reaching the planned total run time. Pump seizure after shut down occurred after one of the tests. Hydraulic performance results showed a slight degradation in the developed head for all cases but one. That one case having a fine grain debris

AED (Automated External Defibrillator) Programs: Questions and Answers

Science.gov (United States)

... In Schools Training Kits RQI AHA Blended Learning & eLearning Guide AHA Instructors ECC Educational Conferences Programs CPR ... In Schools Training Kits RQI AHA Blended Learning & eLearning Guide AHA Instructors ECC Educational Conferences Programs CPR ...

Hands-Only CPR

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... In Schools Training Kits RQI AHA Blended Learning & eLearning Guide AHA Instructors ECC Educational Conferences Programs CPR ... In Schools Training Kits RQI AHA Blended Learning & eLearning Guide AHA Instructors ECC Educational Conferences Programs CPR ...

CPR Facts and Stats

Science.gov (United States)

... In Schools Training Kits RQI AHA Blended Learning & eLearning Guide AHA Instructors ECC Educational Conferences Programs CPR ... In Schools Training Kits RQI AHA Blended Learning & eLearning Guide AHA Instructors ECC Educational Conferences Programs CPR ...

JO OLE MIARON", PG WAHOME' AND IM MAPENAY' 1 Depurtnient ...

African Journals Online (AJOL)

passed through a coffee strainer. While stirring the filtrate. a drop was transferred to the Counting. Chamber of the McMaster slide. The slide was left for 3 min to allow the eggs to rise to the top of the slide. The slide was examined under low power (x 100 objective) and eggs were counted and identified under the microscope ...

Assessment Analysis and Forecasting for Security Early Warning of Energy Consumption Carbon Emissions in Hebei Province, China

Directory of Open Access Journals (Sweden)

Yi Liang

2017-03-01

Full Text Available Against the backdrop of increasingly serious global climate change and the development of the low-carbon economy, the coordination between energy consumption carbon emissions (ECCE and regional population, resources, environment, economy and society has become an important subject. In this paper, the research focuses on the security early warning of ECCE in Hebei Province, China. First, an assessment index system of the security early warning of ECCE is constructed based on the pressure-state-response (P-S-R model. Then, the variance method and linearity weighted method are used to calculate the security early warning index of ECCE. From the two dimensions of time series and spatial pattern, the security early warning conditions of ECCE are analyzed in depth. Finally, with the assessment analysis of the data from 2000 to 2014, the prediction of the security early warning of carbon emissions from 2015 to 2020 is given, using a back propagation neural network based on a kidney-inspired algorithm (KA-BPNN model. The results indicate that: (1 from 2000 to 2014, the security comprehensive index of ECCE demonstrates a fluctuating upward trend in general and the trend of the alarm level is “Severe warning”–“Moderate warning”–“Slight warning”; (2 there is a big spatial difference in the security of ECCE, with relatively high-security alarm level in the north while it is relatively low in the other areas; (3 the security index shows the trend of continuing improvement from 2015 to 2020, however the security level will remain in the state of “Semi-secure” for a long time and the corresponding alarm is still in the state of “Slight warning”, reflecting that the situation is still not optimistic.

Early Childhood Caries and Body Mass Index in Young Children from Low Income Families

Directory of Open Access Journals (Sweden)

Maria Goretti Queiroz

2013-03-01

Full Text Available The relationship between early childhood caries (ECC and obesity is controversial. This cross-sectional survey investigated this association in children from low-income families in Goiania, Goias, Brazil and considered the role of several social determinants. A questionnaire examining the characteristics of the children and their families was administered to the primary caregiver during home visits. In addition, children (approximately 6 years of age had their height, weight, and tooth condition assessed. The primary ECC outcome was categorized as one of the following: caries experience (decayed, missing, filled tooth: “dmft” index > 0, active ECC (decayed teeth > 0, or active severe ECC (decayed teeth ≥ 6. Descriptive, bivariate and logistic regression analyses were conducted. The participants in the current study consisted of 269 caregiver-child dyads, 88.5% of whom were included in the Family Health Program. Caregivers were mostly mothers (67.7%, were 35.3 ± 10.0 years old on average and had 9.8 ± 3.1 years of formal education. The mean family income was 2.3 ± 1.5 times greater than the Brazilian minimum wage. On average, the children in the current study were 68.7 ± 3.8 months old. Of these, 51.7% were boys, 23.4% were overweight or obese, 45.0% had active ECC, and 17.1% had severe ECC. The average body mass index (BMI of the children was 15.9 ± 2.2, and their dmft index was 2.5 ± 3.2. BMI was not associated with any of the three categories of dental caries (p > 0.05. In contrast, higher family incomes were significantly associated with the lack of caries experience in children (OR 1.22, 95%CI 1.01–1.50, but the mother’s level of education was not significantly associated with ECC.

[Reliability of endocervical curettage after conservative treatment of intraepithelial neoplasia of the cervix].

Science.gov (United States)

Lecointre, L; Akladios, C-Y; Averous, G; Lefebvre, F; Baulon, E; Thoma, V; Fender, M; Baldauf, J-J

2015-02-01

To evaluate the reliability of endocervical curettage (ECC) in patients previously treated for CIN. Retrospective analysis of data from 85 patients between January 1985 and December 2011 who received an ECC during monitoring after treatment of CIN. The reliability of the ECC was evaluated by comparison with the final histological analysis of the surgical specimen or the data for subsequent cyto-colpo-histological follow-up. Patients were referred to colposcopy either within the immediate post-treatment monitoring (n=42), meanly 9.7±5.3 months after treatment, or if cytological abnormalities were detected during long-term monitoring, meanly 78.6±52.4 months after treatment. Colposcopy was unsatisfactory in 75.3% of patients and normal colposcopic findings were found in 80% of patients. A perfect agreement between the ECC and the endocervical final diagnosis was noted in 68 patients (80%). For the diagnosis of severe cervical lesions (CIN 2+) ECC had a sensitivity of 86.2% (68.3-96.1), a specificity of 94.6% (85.1-98.9) and positive and negative predictive values of 61.4% (47.6-74.0) and 93% (83.0-98.1), respectively. The high sensitivity and negative predictive value of ECC for the diagnosis of severe post-therapeutic endocervical lesions avoid iterative treatment without increasing the risk of progression of a lesion to cancer. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

EFFECT OF HEAT PRECONDITIONING BY MICROWAVE HYPERTHERMIA ON HUMAN SKELETAL MUSCLE AFTER ECCENTRIC EXERCISE

Directory of Open Access Journals (Sweden)

Norio Saga

2008-03-01

Full Text Available The purpose of this study was to clarify whether heat preconditioning results in less eccentric exercise-induced muscle damage and muscle soreness, and whether the repeated bout effect is enhanced by heat preconditioning prior to eccentric exercise. Nine untrained male volunteers aged 23 ± 3 years participated in this study. Heat preconditioning included treatment with a microwave hyperthermia unit (150 W, 20 min that was randomly applied to one of the subject's arms (MW; the other arm was used as a control (CON. One day after heat preconditioning, the subjects performed 24 maximal isokinetic eccentric contractions of the elbow flexors at 30°·s-1 (ECC1. One week after ECC1, the subjects repeated the procedure (ECC2. After each bout of exercise, maximal voluntary contraction (MVC, range of motion (ROM of the elbow joint, upper arm circumference, blood creatine kinase (CK activity and muscle soreness were measured. The subjects experienced both conditions at an interval of 3 weeks. MVC and ROM in the MW were significantly higher than those in the CON (p < 0.05 for ECC1; however, the heat preconditioning had no significant effect on upper arm circumference, blood CK activity, or muscle soreness following ECC1 and ECC2. Heat preconditioning may protect human skeletal muscle from eccentric exercise-induced muscle damage after a single bout of eccentric exercise but does not appear to promote the repeated bout effect after a second bout of eccentric exercise

Quantitative real-time polymerase chain reaction for Streptococcus mutans and Streptococcus sobrinus in dental plaque samples and its association with early childhood caries.

Science.gov (United States)

Choi, Eun-Jung; Lee, Sung-Hoon; Kim, Young-Jae

2009-03-01

Streptococcus mutans and Streptococcus sobrinus are closely associated with the development of early childhood caries (ECC). Recently, quantitative real-time polymerase chain reaction (qRT-PCR) has been used for rapid and accurate quantification of these bacterial species. This study aims to detect quantitatively the levels of S. mutans and S. sobrinus in plaque samples by qRT-PCR, and to assess their association with the prevalence of ECC in Korean preschool children. One hundred and five children (71 months old or younger) were examined and classified into three groups (caries-free, ECC, severe ECC). Dental plaque samples were collected and qRT-PCR was conducted using oligonucleotide primers specific for glucosyltransferase gene (S. mutans-gtfB, S. sobrinus-gtfU) and universal primer. Pearson's correlation test was conducted to evaluate the relationship between the dmfs (decayed, missing, or filled surfaces primary teeth) scores and the microbiological findings. There was a significant difference between the levels of S. mutans and S. sobrinus in the plaque samples of the three groups (P plaque samples. The children with higher ratio of S. sobrinus to S. mutans in their dental plaque showed higher incidence of ECC.

Emergency core cooling system

International Nuclear Information System (INIS)

Ando, Masaki.

1987-01-01

Purpose: To actuate an automatic pressure down system (ADS) and a low pressure emergency core cooling system (ECCS) upon water level reduction of a nuclear reactor other than loss of coolant accidents (LOCA). Constitution: ADS in a BWR type reactor is disposed for reducing the pressure in a reactor container thereby enabling coolant injection from a low pressure ECCS upon LOCA. That is, ADS has been actuated by AND signal for a reactor water level low signal and a dry well pressure high signal. In the present invention, ADS can be actuated further also by AND signal of the reactor water level low signal, the high pressure ECCS and not-operation signal of reactor isolation cooling system. In such an emergency core cooling system thus constituted, ADS operates in the same manner as usual upon LOCA and, further, ADS is operated also upon loss of feedwater accident in the reactor pressure vessel in the case where there is a necessity for actuating the low pressure ECCS, although other high pressure ECCS and reactor isolation cooling system are not operated. Accordingly, it is possible to improve the reliability upon reactor core accident and mitigate the operator burden. (Horiuchi, T.)

Cold leg condensation tests. Task C. Steam--water interaction tests

International Nuclear Information System (INIS)

Brodrick, J.R.; Loiselle, V.

1974-03-01

A report is presented of tests to determine the condensation efficiency of ECC water injected into a quality fluid mixture flowing through the cold leg. In particular, a specific objective was to determine if the mixture of ECC water and quality fluid reached thermodynamic equilibrium before exiting the cold leg. Further, the stability of the ECC water/quality fluid interaction would be assessed by interpretation of thermocouple records and utilization of a section of cold leg piping with view ports to film the interaction whenever possible. The cold leg condensation tests showed complete condensation of the 5 lbm/sec steam quality mixtures in the cold leg by the ECC water flows of the test matrix. The cold leg exit fluid temperature remained below the saturation temperature and had good agreement with the predicted cold leg outlet temperature, calculated assuming total condensation. (U.S.)

Finite element beam flexural properties of cement composites of fiber reinforced PVA

Science.gov (United States)

Yang, Chengzhi; Pei, Changchun

2018-05-01

In this paper, the initial cracking state and the mid span bending moment and deflection of ECC beam under different PVA fiber and fly ash mixing rate are studied by finite element simulation analysis. The results show that the bending moment of the ECC beam increases with the increase of the PVA fiber content, and the deflection decreases. When the ratio of PVA fiber is 1.5%, the middle bending moment is the largest and the deflection is the least. With the increase of fly ash content, the mid span bending moment of ECC beam increases first and then decreases. When the fly ash ratio is 60%, the middle bending moment is the largest and the deflection is the least. Through the study, the formula for calculating the flexural capacity of the cross section suitable for ECC beams is derived.

Metallic insulation transport and strainer clogging tests

International Nuclear Information System (INIS)

Hyvaerinen, J.; Hongisto, O.

1994-06-01

Experiments to probe the transport and clogging properties of metallic (metal reflective) insulation have been carried out in order to provide data for evaluation of their influence on the emergency core cooling and containment spray systems of the Finnish boiling water reactors in the event of a design basis accident. The specific metallic insulation tested was DARMET, provided by Darchem Engineering Ltd. The inner foils of Darmet are dimped. Available literature on the metallic insulation performance under design basis accident conditions has been reviewed. On the basis of the review a parametric approach has been chosen for the transport and clogging experiments. This approach involves testing a wide size range of various shapes of foil pieces. Five sets of experiments have been carried out. The first three sets investigate transport properties of the foil pieces, starting from sedimentation in stagnant waste pool and proceeding to transport in horizontal and vertically circulating flows. The clogging experiments have been addressed the differential pressures obtained due to accumulation of both pure and metallic and a mixture of metallic and fibrous (mineral wool) depris. (4 refs., 24 figs., 2 tabs.)

Classical description of the electron capture to the continuum cusp formation in ion-atom collisions

International Nuclear Information System (INIS)

Illescas, Clara; Pons, B.; Riera, A.

2002-01-01

Classical calculations are used to describe the dynamics of the electron capture to the continuum (ECC) cusp formation in H + +He collisions. We illustrate the frontier character of the ECC electrons between capture and ionization, and confirm that it is a temporary capture, through projectile focusing, that is responsible for the ECC cusp. Furthermore, the cusp is not a divergence smoothed by the experiment, and is slightly shifted from the impact-velocity value because of the residual pull from the target after ionization. This shift is larger the smaller the nuclear velocity

Study on the distribution of streaming potential while groundwater pumping up; Chikasui no kumiage ni tomonau ryudo den`i hassei ni kansuru kento

Energy Technology Data Exchange (ETDEWEB)

Sato, H; Shima, H; Sakurai, K [OYO Corp., Tokyo (Japan)

1997-10-22

This paper describes effectiveness of water channel prospecting by means of streaming potential method. To investigate the distribution of streaming potential on the ground surface while groundwater pumping up, some laboratory experiments were performed. A system was constructed, in which fluid is flowed in an experimental cistern from its both ends and self-flowed through a strainer pipe fixed for flowing out the fluid at the center of the cistern. Streaming potential with the flowing of the fluid was observed. Positive streaming potential waveform was generated with the flowing of the fluid, and the potential increased with approaching the strainer pipe. A groundwater pumping test facility was used as a field test site. There was a positive maximal point of potential distribution at about 30 m far from the pumping well in the southeast direction. The potential gradually decreased in the eastern part from the maximal point. The potential steeply decreased in the northwest direction from the pumping well. From these experiments, it was found that the groundwater flow and underground structures can be reflected by the distribution of streaming potential, and that the present method is effective for water channel prospecting. 3 refs., 8 figs.

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

DEFF Research Database (Denmark)

Møller, Henrik D.; Bojsen, Rasmus Kenneth; Tachibana, Chris

2016-01-01

Extrachromosomal circular DNAs (eccDNAs) are common genetic elements in Saccharomyces cerevisiae and are reported in other eukaryotes as well. EccDNAs contribute to genetic variation among somatic cells in multicellular organisms and to evolution of unicellular eukaryotes. Sensitive methods...

Medline Plus

Full Text Available ... the blockage, then a catheter designed for lesion cutting is advanced across the blockage site. A low- ... is exposed to the cutter. The cutter spins, cutting away pieces of the blockage. These lesion pieces ...

Changes in central corneal thickness and endothelial cell count pediatric cataract surgery

International Nuclear Information System (INIS)

Memon, M.N.

2015-01-01

To evaluate the mean changes in Central Corneal Thickness (CCT) and Endothelial Cell Count (ECC) in eyes after pediatric cataract surgery with foldable intraocular lens using scleral tunnel incision micro-surgical technique. Study Design: Qausi experimental study. Place and Duration of Study: Department of Pediatric Ophthalmology and Strabismus, Al-Shifa Trust Eye Hospital, Rawalpindi, from May 2011 to March 2012. Methodology: Fifty-two eyes of 37 children with pediatric cataract were included in the study. Extracapsular Cataract Extraction (ECE) with foldable Intra Ocular Lens (IOL) implantation using sclera tunnel incision was performed in all children. Endothelial Cell Count (ECC) and Central Corneal Thickness (CCT) were recorded before surgery and 1 month, 3 months and 6 months after surgery and the effect of currently practiced surgical technique on ECC and CCTwas evaluated. Results: The mean age at the time of surgery was 8.8 ± 2.7 years (range: 4 to 15 years). The postoperative ECC and CCT were significantly different from the pre-operative values. Mean pre-operative ECC was 3175.3 ± 218.4 cell/mm2 and in first postoperative month the mean ECC was 3113.4 ± 210.8 cell/mm2 (p<0.0001). In the 3rd and 6th month postoperative means ECC were 3052 ± 202.5 cell/mm2 (p<0.0001) and 3015 ±190.6 cell/mm2 (p<0.0001), respectively. The mean cell loss at first postoperative month was 1.95% and at 3rd and 6th postoperative month were 3.9% and 5.05%, respectively. Mean pre-operative CCT was 514 ± 49.9 micro m and first postoperative mean CCT after 1 month was 524.1 ± 25 micro m (p = 0.084). After the 3rd and 6th months postoperative, mean CCT were 527.3 ± 24.6 micro m, and 530 ± 24.5 micro m, respectively. Third and 6th months postoperative means were significantly higher than baseline CCT, p = 0.024 and 0.007, respectively. Conclusion: Endothelial cell loss with closed chamber micro-surgical technique using scleral tunnel incision is within acceptable limits and

Phenomenological interpretation of the shear behavior of reinforced Engineered Cementitious Composite beams

DEFF Research Database (Denmark)

Paegle, Ieva; Fischer, Gregor

2016-01-01

This paper describes an experimental investigation of the shear behavior of beams consisting of steel Reinforced Engineered Cementitious Composites (R/ECC). This study investigates and quantifies the effect of ECC's strain hardening and multiple cracking behavior on the shear capacity of beams...

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

DEFF Research Database (Denmark)

Møller, Henrik D.; Bojsen, Rasmus Kenneth; Tachibana, Chris

2016-01-01

Extrachromosomal circular DNAs (eccDNAs) are common genetic elements in Saccharomyces cerevisiae and are reported in other eukaryotes as well. EccDNAs contribute to genetic variation among somatic cells in multicellular organisms and to evolution of unicellular eukaryotes. Sensitive methods for d...

Draft pilot report - Approaches to the resolution of safety issues

International Nuclear Information System (INIS)

2006-01-01

The purpose of this report is to present in a concise form how some safety matters associated with currently operating light water reactors have been addressed. The issues discussed in this report are common to member countries with currently operating LWRs (PWR, BWR, VVER) and, as such, have wide interest in the nuclear safety community. Accordingly, this report can serve as a reference for researchers, regulations and others (e.g., industry) interested in understanding the approach and status of issues. This report should also be useful for knowledge transfer by documenting what has been done or is planned regarding selected safety matters and as a source for identifying reference material containing additional detail. The issues addressed in this report should not be viewed as questioning the safety of operating reactors, which have reached very high operational safety record, but rather as areas where uncertainty in knowledge exists, where safety assessment has been based on conservative assumptions, and where regulatory decisions need, or will need to be confirmed. Thus, the development of sound technical bases through continuing research will improve the current knowledge and allow for more realistic safety assessment. The safety issues discussed in this initial version of the report are: - design basis accident spectrum; - severe accident issues; - reactor pressure vessel integrity; - hydrogen control; - containment integrity; - accident management; - station blackout; - high burnup fuel; - power up-rates; - ECCS strainer clogging; - boron dilution. For each issue, the scope of the issue is defined, its status discussed and planned work or research described, including schedule. This pilot version of the report is limited to input from nine countries (Belgium, Czech Republic, Finland, France, Germany, Japan, Korea, Sweden and the U.S.). An overview of this information for each issue by country is provided in the table. This document does not contain a

Development of explicit solution scheme for the MATRA-LMR code and test calculation

International Nuclear Information System (INIS)

Jeong, H. Y.; Ha, K. S.; Chang, W. P.; Kwon, Y. M.; Jeong, K. S.

2003-01-01

The local blockage in a subassembly of a liquid metal reactor is of particular importance because local sodium boiling could occur at the downstream of the blockage and integrity of the fuel clad could be threatened. The explicit solution scheme of MATRA-LMR code is developed to analyze the flow blockage in a subassembly of a liquid metal cooled reactor. In the present study, the capability of the code is extended to the analysis of complete blockage of one or more subchannels. The results of the developed solution scheme shows very good agreement with the results obtained from the implicit scheme for the experiments of flow channel without any blockage. The applicability of the code is also evaluated for two typical experiments in a blocked channel. Through the sensitivity study, it is shown that the explicit scheme of MATRA-LMR predicts the flow and temperature profile after blockage reasonably if the effect of wire is suitably modeled. The simple assumption in wire-forcing function is effective for the un-blocked case or for the case of blockage with lower velocity. A different type of wire-forcing function describing the velocity reduction after blockage or an accurate distributed resistance model is required for more improved predictions

Exercise Based- Pain Relief Program

DEFF Research Database (Denmark)

Zadeh, Mahdi Hossein

in the current study was to use exercise induced- muscle damage followed by ECC as an acute pain model and observe its effects on the sensitivity of the nociceptive system and blood supply in healthy subjects. Then, the effect of a repeated bout of the same exercise as a healthy pain relief strategy......Exercise-based pain management programs are suggested for relieving from musculoskeletal pain; however the pain experienced after unaccustomed, especially eccentric exercise (ECC) alters people´s ability to participate in therapeutic exercises. Subsequent muscle pain after ECC has been shown...... to cause localized pressure pain and hyperalgesia. A prior bout of ECC has been repeatedly reported to produce a protective adaptation known as repeated bout effect (RBE). One of the main scopes of the current project was to investigate the adaptations by which the RBE can be resulted from. The approach...

Analysis of a total flow blockage of a Fuel Assembly in a typical MTR Research Reactor by RELAP5/MOD3.3

International Nuclear Information System (INIS)

Adorni, M.; Salah, A.B.; Di Maro, B.; Pierro, F.; D'Auria, F.; Hamidouche, T.

2004-01-01

The lack of full understanding of complex mechanisms connected with the interaction between thermal-hydraulics and neutronics still challenge the design and the operation of nuclear reactors by the adoption of conservative safety limits. The recent availability of powerful computer and computational techniques together with the continuing increase in operational experience imposes the revisiting of those areas and eventually the identification of design/safety requirements that can be relaxed [1]. Currently, the enlarged commercial exploitation of nuclear Research Reactors (RR) has increased the consideration to their corresponding safety issues. Almost all of the safety analyses have so far been performed using conservative computational tools [2]. Nowadays, the application of Best-Estimate (BE) methods constitutes a real necessity in order to increase their commercial productivity. In this framework, an attempt is made to apply the BE technique to perform a safety evaluation under research reactors operational conditions. In fact, this technique has been largely verified and validated for power reactors using coupled system thermal-hydraulic and three-dimensional neutron kinetics [1]. For this purpose, as typical representative of research reactors, the IAEA 10 MW MTR Research Reactors problem [3] is considered. The system thermal-hydraulic RELAP5 [4] code was developed to simulate transient scenarios in Power reactors such PWR, BWR, VVER, etc. However, only limited work was performed to access the applicability of the code to Research Reactors operating conditions (low pressure, mass flow rates, power, etc) [5]. Previous works performed in this field are reported in [5], [6] and [7]. In this framework, total and partial blockage of a single Fuel Assembly cooling channel are investigated. As a first attempt the calculations are performed by applying the BE thermal-hydraulic system code RELAP5 alone using its point kinetic model to derive the instantaneous core

The reliability of jump kinematics and kinetics in children of different maturity status.

Science.gov (United States)

Meylan, Cesar M P; Cronin, John B; Oliver, Jon L; Hughes, Michael G; McMaster, D Travis

2012-04-01

The purpose of this study was to determine the reliability of eccentric (ECC) and concentric (CON) kinematic and kinetic variables thought to be critical to jump performance during bilateral vertical countermovement jump (VCMJ) and horizontal countermovement jump (HCMJ) across children of different maturity status. Forty-two athletic male and female participants between 9 and 16 years of age were divided into 3 maturity groups according to peak height velocity (PHV) offset (Post-PHV, At-PHV, and Pre-PHV) and percent of predicted adult stature. All the participants performed 3 VCMJ and HCMJ trials and the kinematics, and kinetics of these jumps were measured via a force plate over 3 testing sessions. In both jumps, vertical CON mean and peak power and jump height or distance were the most reliable measures across all groups (change in the mean [CM] = -5.4 to 6.2%; coefficient of variation [CV] = 2.1-9.4%; Intraclass correlation coefficient [ICC] = 0.82-0.98), whereas vertical ECC mean power was the only ECC variable with acceptable reliability for both jumps (CM = -0.7 to 10.1%; CV = 5.2-15.6%; ICC = 0.74-0.97). A less mature state was "likely" to "very likely" to reduce the reliability of the HCMJ ECC kinetics and kinematics. These findings suggested that movement variability is associated with the ECC phase of CMJs, especially in Pre-PHV during the HCMJ. Vertical CON mean and peak power and ECC mean power were deemed reliable and appropriate to be used in children as indicators of jump and stretch-shortening cycle performance.

Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1 during coronary artery bypass surgery

Directory of Open Access Journals (Sweden)

Orsel Isabelle

2007-09-01

Full Text Available Abstract Background This study was conducted to follow plasma concentrations of sFlt-1 and sKDR, two soluble forms of the vascular endothelial growth factor (VEGF receptor in patients undergoing coronary artery bypass graft (CABG surgery with extracorporeal circulation (ECC. Methods Plasma samples were obtained before, during and after surgery in 15 patients scheduled to undergo CABG. Levels of sFlt-1 and KDR levels were investigated using specific ELISA. Results A 75-fold increase of sFlt-1 was found during cardiac surgery, sFlt-1 levels returning to pre-operative values at the 6th post-operative hour. In contrast sKDR levels did not change during surgery. The ECC-derived sFlt-1 was functional as judge by its inhibitory effect on the VEGF mitogenic response in human umbilical vein endothelial cells (HUVECs. Kinetic experiments revealed sFlt-1 release immediately after the beginning of ECC suggesting a proteolysis of its membrane form (mFlt-1 rather than an elevated transcription/translation process. Flow cytometry analysis highlighted no effect of ECC on the shedding of mFlt-1 on platelets and leukocytes suggesting vascular endothelial cell as a putative cell source for the ECC-derived sFlt-1. Conclusion sFlt-1 is released during CABG with ECC. It might be suggested that sFlt-1 production, by neutralizing VEGF and/or by inactivating membrane-bound Flt-1 and KDR receptors, might play a role in the occurrence of post-CABG complication.

A Plastic Damage Mechanics Model for Engineered Cementitious Composites

DEFF Research Database (Denmark)

Dick-Nielsen, Lars; Stang, Henrik; Poulsen, Peter Noe

2007-01-01

This paper discusses the establishment of a plasticity-based damage mechanics model for Engineered Cementitious Composites (ECC). The present model differs from existing models by combining a matrix and fiber description in order to describe the behavior of the ECC material. The model provides...

Characterization of the population structure, drug resistance mechanisms and plasmids of the community-associated Enterobacter cloacae complex in China

NARCIS (Netherlands)

Zhou, Kai; Yu, Wei; Cao, Xiaoli; Shen, Ping; Lu, Haifeng; Luo, Qixia; Rossen, John W. A.; Xiao, Yonghong

Objectives: To investigate the population structure, drug resistance mechanisms and plasmids of community-associated Enterobacter cloacae complex (CA-ECC) isolates in China. Methods: Sixty-two CA-ECC isolates collected from 31 hospitals across China were typed by hsp60 typing and MLST. ESBL and

Engineered cementitious composites with low volume of cementitious materials

NARCIS (Netherlands)

Zhou, J.; Quian, S.; Van Breugel, K.

2010-01-01

Engineered cementitious composite (ECC) is an ultra ductile cement-based material reinforced with fibers. It is characterized by high tensile ductility and tight crack width control. Thanks to the excellent performance, ECC is emerging in broad applications to enhance the loading capacity and the

Cost-effectiveness analysis of cataract surgery with intraocular lens implantation: extracapsular cataract extraction versus phacoemulsification

Directory of Open Access Journals (Sweden)

Mohd R.A. Manaf

2007-03-01

Full Text Available A randomized single blinded clinical trial to compare the cost-effectiveness of cataract surgery between extracapsular cataract extraction (ECCE and phacoemulsification (PEA was conducted at Hospital Universiti Kebangsaan Malaysia (HUKM from March 2000 until August 2001. The cost of a cataract surgery incurred by hospital, patients and households were calculated preoperatively, one week, two months (for both techniques and six months (for ECCE only. Effectiveness of cataract surgery was assessed using Visual Function 14 (VF-14, quality of life measurement specifically for vision. The cost analysis results from each 50 subjects of ECCE and PEA group showed that average cost for one ECCE after six months post-operation is USD 458 (± USD 72 and for PEA is USD 528 (± USD 125. VF-14 score showed a significant increased after a week, two months and six months post-operation compared to the score before operation for both techniques (p<0.001. However, there was no significant difference between them (p = 0.225. This study indicated that ECCE is more cost effective compared to PEA with cost per one unit increment of VF-14 score of USD 14 compared to USD 20 for PEA. (Med J Indones 2007; 16:25-31 Keywords: cataract, cost-effectiveness, extracapsular cataract extraction, phacoemulsification, visual function 14

Prevalence of early childhood caries and its risk factors in 18-72 month old children in Salem, Tamil Nadu.

Science.gov (United States)

Stephen, Arokiaraj; Krishnan, Ramesh; Ramesh, Maya; Kumar, Vasaviah Suresh

2015-01-01

Early childhood caries (ECC) is one of the most common dental diseases among the preschoolers, leading to suboptimal health. A study was planned to evaluate the prevalence of ECC in preschool children in the age group between 18 and 72 months and its relationship with parent's education and socioeconomic status of the family. This cross-sectional study was conducted among 2771 children selected randomly, in the age group 18-72 months and attending playschools and primary schools in urban, semi-urban, and rural areas of Salem, Tamil Nadu. A modified Winter et al. questionnaire and a proforma were used for collecting information on each child. The completed questionnaire and proformas were statistically analyzed and evaluated. The statistical analysis was done using Student's t-test and analysis of variance (ANOVA) to obtain mean values. The prevalence of ECC in Salem was 16% with a mean dfs of 5.23 ± 1. Prevalence was high among the children of low socioeconomic status group and the children of working mothers, with a mean dfs of 10.47. The prevalence of ECC was 16% in Salem, Tamil Nadu. ECC was seen more in children of working mothers, lower parental education, and lower socioeconomic groups.

Development of Ecoefficient Engineered Cementitious Composites Using Supplementary Cementitious Materials as a Binder and Bottom Ash Aggregate as Fine Aggregate

Directory of Open Access Journals (Sweden)

Jin Wook Bang

2015-01-01

Full Text Available The purpose of this study is to develop ecoefficient engineered cementitious composites (ECC using supplementary cementitious materials (SCMs, including fly ash (FA and blast furnace slag (SL as a binder material. The cement content of the ECC mixtures was replaced by FA and SL with a replacement rate of 25%. In addition, the fine aggregate of the ECC was replaced by bottom ash aggregate (BA with a substitution rate of 10%, 20%, and 30%. The influences of ecofriendly aggregates on fresh concrete properties and on mechanical properties were experimentally investigated. The test results revealed that the substitution of SCMs has an advantageous effect on fresh concrete’s properties; however, the increased water absorption and the irregular shape of the BA can potentially affect the fresh concrete’s properties. The substitution of FA and SL in ECC led to an increase in frictional bond at the interface between PVA fibers and matrix, improved the fiber dispersion, and showed a tensile strain capacity ranging from 3.3% to 3.5%. It is suggested that the combination of SCMs (12.5% FA and 12.5% SL and the BA aggregate with the substitution rate of 10% can be effectively used in ECC preparation.

Salivary Cortisol as a Biomarker to Explore the Role of Maternal Stress in Early Childhood Caries

Directory of Open Access Journals (Sweden)

Sharat Chandra Pani

2013-01-01

Full Text Available Objective. To compare salivary cortisol levels of children with ECC and their mothers with those of caries free children from a similar sociodemographic cohort. Design. Sixty-four college-educated, working mothers from middle income families with no history of anxiety disorders and their first born children aged between 48 and 71 months were included in the study. Salivary cortisol levels were analyzed using electrochemiluminescence (ECL immunoassay. Statistical Analyses. Significance of difference between the cortisol levels of children with ECC and control children and of their mothers was analyzed using the Student’s t- test. The intraclass correlation coefficient was used to measure the significance of correlation of cortisol levels between the mother and the child with logistic regression to explore possible associations. Results. Mothers of children with ECC had significantly higher levels of salivary cortisol ( than mothers of caries free children. The salivary cortisol levels of children with ECC were significantly higher than caries free children (. A significant correlation existed between the salivary cortisol level of the mother and that of the child (. Conclusion. While salivary cortisol levels of the child seem to have a direct impact on the incidence of ECC, maternal stress seems to have an indirect effect.

Instrumentation in the Rapsodie test circuits of 1 and 10 MW - flow-meters, manometers, level indicators, blockage indicators; L'instrumentation dans les cilicuits d'essais rapsodie 1 et 10 MW - debitmetres, manometres, indicateurs de niveau, indicateurs de bouchage

Energy Technology Data Exchange (ETDEWEB)

Lisle, J.P. de; Lions, N [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-07-01

The main measuring instruments, which operate in the presence of liquid metals and which have been developed by the liquid metal section over the last few years, are electromagnetic flowmeters, differential manometers, level indicators and blockage indicators. We give here results obtained with these instruments during trial, in the 1 and 10 MW test circuits, together with the conclusions drawn about their possible use in the reactor Rapsodie, The flow rate measurements are carried out using electromagnetic flow meters with permanent magnets. We have studied more particularly the reliability of these instruments. The measurements matte show that the induction in the space between the poles is very constant with time and in the presence of the prevailing demagnetization phenomena to which the magnets are subjected. The differential manometers placed in the test circuits are very accurate. It is nevertheless necessary to carry out some technological modifications on them in order that they may operate satisfactorily over long periods. The continuous and discontinuous level-indicators tried out operate on the principle of a change in resistance. Studies carried out on the test loops of the reliability and of the accuracy of this equipment have shown the existence of phenomena convected with the condensation of sodium vapour on the upper parts of the reservoir, and have shown the importance of the condensed deposits when the oxygen content of the covering gas is appreciable. From the various blockage indicators tried out, the one chosen for equipping the reactor circuits is an automatic model with continuous recording. The development and testing of this apparatus has been going on for one year on an industrial scale circuit and has made it possible to show clearly an effect of a double blockage temperature. (authors) [French] Les principaux instruments de mesure, fonctionnant en presence de metal liquide, qui ont ete developpes et mis au point a la Section des Metaux

78 FR 18375 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Science.gov (United States)

2013-03-26

... Pike, Rockville, Maryland. Thursday, April 11, 2013, Conference Room T2-B1, 11545 Rockville Pike..., ``Westinghouse BWR ECCS Evaluation Model: Supplement 5--Application to the ABWR,'' Revision 0 (Open/Closed)--The...-17116-P, ``Westinghouse BWR Emergency Core Coolant System (ECCS) Evaluation Model: Supplement 5,'' and...

Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study.

Science.gov (United States)

Yamini, Goli; Kalu, Nnanya; Nestorovich, Ekaterina M

2016-11-15

Nearly all the cationic molecules tested so far have been shown to reversibly block K⁺ current through the cation-selective PA 63 channels of anthrax toxin in a wide nM-mM range of effective concentrations. A significant increase in channel-blocking activity of the cationic compounds was achieved when multiple copies of positively charged ligands were covalently linked to multivalent scaffolds, such as cyclodextrins and dendrimers. Even though multivalent binding can be strong when the individual bonds are relatively weak, for drug discovery purposes we often strive to design multivalent compounds with high individual functional group affinity toward the respective binding site on a multivalent target. Keeping this requirement in mind, here we perform a single-channel/single-molecule study to investigate kinetic parameters of anthrax toxin PA 63 channel blockage by second-generation (G2) poly(amido amine) (PAMAM) dendrimers functionalized with different surface ligands, including G2-NH₂, G2-OH, G2-succinamate, and G2-COONa. We found that the previously reported difference in IC 50 values of the G2-OH/PA 63 and G2-NH₂/PA 63 binding was determined by both on- and off-rates of the reversible dendrimer/channel binding reaction. In 1 M KCl, we observed a decrease of about three folds in k o n and a decrease of only about ten times in t r e s with G2-OH compared to G2-NH₂. At the same time for both blockers, k o n and t r e s increased dramatically with transmembrane voltage increase. PAMAM dendrimers functionalized with negatively charged succinamate, but not carboxyl surface groups, still had some residual activity in inhibiting the anthrax toxin channels. At 100 mV, the on-rate of the G2-succinamate binding was comparable with that of G2-OH but showed weaker voltage dependence when compared to G2-OH and G2-NH₂. The residence time of G2-succinamate in the channel exhibited opposite voltage dependence compared to G2-OH and G2-NH₂, increasing with the cis

Early Childhood Caries

Directory of Open Access Journals (Sweden)

Yumiko Kawashita

2011-01-01

Full Text Available Dental caries is one of the most common childhood diseases, and people continue to be susceptible to it throughout their lives. Although dental caries can be arrested and potentially even reversed in its early stages, it is often not self-limiting and progresses without proper care until the tooth is destroyed. Early childhood caries (ECC is often complicated by inappropriate feeding practices and heavy infection with mutans streptococci. Such children should be targeted with a professional preventive program that includes oral hygiene instructions for mothers or caregivers, along with fluoride and diet counseling. However, these strategies alone are not sufficient to prevent dental caries in high-risk children; prevention of ECC also requires addressing the socioeconomic factors that face many families in which ECC is endemic. The aim of this paper is to systematically review information about ECC and to describe why many children are suffering from dental caries.

Social and Behavioral Determinants for Early Childhood Caries among Preschool Children in India

Directory of Open Access Journals (Sweden)

Mitali Jain

2015-06-01

Full Text Available Background and aims. Early Childhood Caries (ECC is a public health problem with biological, social and behavioural determinants and the notion that the principal etiology is inappropriate feeding modalities is no longer tenable. Hence this study was undertaken to assess the relationship between ECC and socio-demographic factors, dietary habits, oral hygiene habits and parental characteristics. Materials and methods. The study involved a dental examination of 1400 children aged 0‒71 months, recording caries using Gruebbel’s deft index and a structured questionnaire to interview parents or caretakers. The tabulated data was statis-tically analyzed using t-test and ANOVA at 5% level of significance. Results. The variables significantly associated with ECC were age (P0.05. Conclusion. ECC is preventable and manageable with proper information and skills. It is important for healthcare profes-sionals, family physicians and parents to be cognizant of the involved risk factors as their preventive efforts represent the first line of defense.

Air contamination during hemodialysis should be minimized.

Science.gov (United States)

Stegmayr, Bernd

2017-04-01

During preparation of the hemodialysis (HD) extracorporeal circuit (ECC) a priming solution is used to remove air from the tubes and dialyzer. Ultra sound techniques have verified micro embolic signals (MES) in the ECC that may derive from clots or gas embolies. In vitro studies could clarify that embolies of air develop within the ECC and also pass the safety systems such as air traps and enter the venous line that goes into the patient. Clinical studies have confirmed the presence of MES within the ECC that pass into the return-venous-line during conventional HD without inducing an alarm. In addition, studies confirmed that such MES were present within the AV fistula and subclavian vein, but also detected within the carotid artery. Autopsy studies revealed the presence of gas embolies surrounded by clots within the lung but also brain and myocardial tissue. This review will focus on how the MES develop and measures of how the exposure can be limited. © 2016 International Society for Hemodialysis.

Factors associated with the development of early childhood caries among Brazilian preschoolers

Directory of Open Access Journals (Sweden)

Patrícia Corrêa-Faria

Full Text Available The aim of this study was to assess the prevalence of early childhood caries (ECC in children and investigate the influence of sociodemographic variables, quality of oral hygiene and child-related aspects. A cross-sectional study was carried out with 593 children aged three to five years. Data were collected through clinical examinations and interviews with parents. Interviews with parents of the children were conducted to acquire information on sociodemographic aspects, breastfeeding, bottle feeding and harmful oral habits. Statistical analysis involved the chi-square test and the Poisson regression. The prevalence of ECC was 53.6%. The occurrence of ECC was greater among children with unsatisfactory oral hygiene (PR: 2.95; 95% CI: 2.42-3.60 and those from a family with a lower monthly household income (PR: 1.62; 95% CI: 1.24-2.10. In conclusion, unsatisfactory oral hygiene and monthly income exerted an influence on the occurrence of ECC among preschoolers.

The effect of a polyurethane coating incorporating both a thrombin inhibitor and nitric oxide on hemocompatibility in extracorporeal circulation

Science.gov (United States)

Major, Terry C.; Brisbois, Elizabeth J.; Jones, Anna M.; Zanetti, Margaux E.; Annich, Gail M.; Bartlett, Robert H.; Handa, Hitesh

2014-01-01

Nitric oxide (NO) releasing (NORel) materials have been extensively investigated to create localized increases in NO concentration by the proton driven diazeniumdiolate-containing polymer coatings and demonstrated to improve extracorporeal circulation (ECC) hemocompatibility. In this work, the NORel polymeric coating composed of a diazeniumdiolated dibutylhexanediamine (DBHD-N2O2)-containing hydrophobic Elast-eon™ (E2As) polyurethane was combined with a direct thrombin inhibitor, argatroban (AG), and evaluated in a 4 h rabbit thrombogenicity model without systemic anticoagulation. In addition, the immobilizing of argatroban to E2As polymer was achieved by either a polyethylene glycol-containing (PEGDI) or hexane methylene (HMDI) diisocyanate linker. The combined polymer film was coated on the inner walls of ECC circuits to yield significantly reduced ECC thrombus formation compared to argatroban alone ECC control after 4 h blood exposure (0.6 ± 0.1 AG/HMDI/NORel vs 1.7 ± 0.2 cm2 AG/HMDI control). Platelet count (2.8 ± 0.3 AG/HMDI/NORel vs 1.9 ± 0.1 × 108/ml AG/HMDI control) and plasma fibrinogen levels were preserved after 4 h blood exposure with both the NORel/argatroban combination and the AG/HMDI control group compared to baseline. Platelet function as measured by aggregometry remained near normal in both the AG/HMDI/NORel (63 ± 5%) and AG/HMDI control (58 ± 7%) groups after 3 h compared to baseline (77 ± 1%). Platelet P-selectin mean fluorescence intensity (MFI) as measured by flow cytometry also remained near baseline levels after 4 h on ECC to ex vivo collagen stimulation (16 ± 3 AG/HMDI/NORel vs 11 ± 2 MFI baseline). These results suggest that the combined AG/HMDI/NORel polymer coating preserves platelets in blood exposure to ECCs to a better degree than AG/PEGDI/NORel, NORel alone or AG alone. These combined antithrombin, NO-mediated antiplatelet effects were shown to improve thromboresistance of the AG/HMDI/NORel polymer-coated ECCs and move

Blockage of upper airway

Science.gov (United States)

... throat swell closed, including allergic reactions to a bee sting , peanuts, antibiotics (such as penicillin), and blood ... The following methods may help prevent an obstruction: Eat slowly and chew food completely. Do not drink ...