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Sample records for ebd

  1. Evidence-Based Teaching Strategies for Students with EBD

    Science.gov (United States)

    Ryan, Joseph B.; Pierce, Corey D.; Mooney, Paul

    2008-01-01

    Students with emotional and behavioral disorders (EBD) struggle in school, perhaps more so than any other group of students. Whereas it is commonly recognized that these children and adolescents have severe social skills deficits, which impede development of meaningful relationships with peers and teachers, it is also true that students with EBD…

  2. Evidence-Based Social Skills Interventions for Students at Risk for EBD

    Science.gov (United States)

    Gresham, Frank

    2015-01-01

    Children and youth with or at risk for emotional and behavioral disorders (EBDs) present substantial challenges for schools, teachers, parents, and peers. Social skills interventions have been shown to be effective for this population. Meta-analytic reviews of this literature show that about 65% of students with EBD will improve when given social…

  3. Using Self-Regulated Strategy Development to Help High School Students with EBD Summarize Informational Text in Social Studies

    Science.gov (United States)

    Ennis, Robin Parks

    2016-01-01

    Students with emotional and behavioral disorders (EBD) often struggle to be effective writers. Self-regulated strategy development (SRSD) is one approach to writing instruction that has demonstrated success for students with EBD. However, there is little research exploring its utility to teach writing to students with EBD in social studies. The…

  4. The evidence-based dentistry champions: a grassroots approach to the implementation of EBD.

    Science.gov (United States)

    Frantsve-Hawley, Julie; Meyer, Daniel M

    2008-06-01

    In order for evidence-based dentistry (EBD) to become part of decision making in practice, the most current and comprehensive research findings must be translated into practice. The use of Champions, influential individuals to support the transfer of knowledge among their peers, is one effective approach used by others in the health care field to successfully implement science research into clinical care. With the success of Champions in other health care areas, the American Dental Association (ADA) and the Journal of Evidence-Based Dental Practice, through an educational grant from Procter and Gamble, have launched a novel program to develop Evidence-Based Dentistry Champions. The EBD Champion program is developing a network of oral health care workers who will disseminate information about the application of an evidence-based approach to dental care and will serve as resources and mentors to their colleagues. The primary mechanism for developing the network of EBD Champions is through 3 annual EBD Champion Conferences, the first of which will be held at the ADA Headquarters in Chicago, IL, on May 2 and 3, 2008. The EBD Champion will serve as a resource to the practitioners in their communities, providing a grassroots approach to facilitating the implementation of an evidence-based approach to providing dental care.

  5. A Review of Self-Regulated Strategy Development for Writing for Students with EBD

    Science.gov (United States)

    Sreckovic, Melissa A.; Common, Eric A.; Knowles, Meagan M.; Lane, Kathleen Lynne

    2014-01-01

    In this systematic review, we evaluated the evidence base of self-regulated strategy development (SRSD; Harris & Graham, 1992) for writing with students with and at risk for emotional or behavioral disorders (EBD). First, we evaluated the quality of studies identified (n 5 13) by applying the quality indicators for single case (Horner et al.,…

  6. Reflections and Perceptions: My Third of a Century in the Field of EBD.

    Science.gov (United States)

    Guetzloe, Eleanor

    2001-01-01

    A professor of special education specializing in students with emotional or behavioral disorders (EBD) reviews her career from 1966 to the present noting the influence of the literature, authorities, and Public Law 94-142. Changes during this time identified include more effective interventions and increasing danger from student weapons. She urges…

  7. Meeting the Diverse Needs of Students with EBD in Inclusive Science Classrooms

    Science.gov (United States)

    Watt, Sarah J.; Therrien, William J.; Kaldenberg, Erica R.

    2014-01-01

    This article reports that for students with emotional and behavioral disorders (EBD), difficulties in core academic skills may play a large role in student success or failure in science. Why? Comprehending science texts can be particularly problematic with their complex and often unknown vocabulary words. Another problem identified as an…

  8. K-12 Principal's Perceptions of Educational Programming for Students with Emotional and Behavioral Disorders (EBD)

    Science.gov (United States)

    Knuth, Richard; Beaudoin, Kathleen M.; Benner, Greg

    2007-01-01

    This study investigated school administrators' perceptions of the effectiveness of their programs serving students with emotional behavioral disorders (EBD). Specifically, the perceptions of principals in schools that provided self-contained programs were compared to the perceptions of principals in schools without self-contained programs. Also…

  9. Improving Mathematics Performance among Secondary Students with EBD: A Methodological Review

    Science.gov (United States)

    Mulcahy, Candace A.; Krezmien, Michael P.; Travers, Jason

    2016-01-01

    In this methodological review, the authors apply special education research quality indicators and standards for single case design to analyze mathematics intervention studies for secondary students with emotional and behavioral disorders (EBD). A systematic methodological review of literature from 1975 to December 2012 yielded 19 articles that…

  10. The effect of systematic academic instruction on behavioural and academic outcomes of students with EBD

    NARCIS (Netherlands)

    van der Kamp, Lidy; Pijl, Sip Jan; Post, Wendy J.; Bijstra, Jan O.; van den Bosch, Els J.

    2016-01-01

    This study aims to assess the impact of systematic academic instruction on academic progress and behavioural problems of students with emotional and/or behavioural disorders (EBD) in special education. Earlier studies have noted the importance of a systematic approach as well as the significance of

  11. Understanding Positive and Negative Communication Instances between Special Educators and Parents of High School Students with EBD

    Science.gov (United States)

    Mires, Carolyn B.

    2015-01-01

    Using a multiple case study methodology, interviews were conducted to examine current practices and perceptions of the communication practices of teachers working with high school students with emotional and behavioral disorders (EBD). These interviews involved questions about general communication instances which occurred each week, communication…

  12. Understanding Positive and Negative Communication Instances between Special Educators and Parents of High School Students with EBD

    Science.gov (United States)

    Mires, Carolyn B.

    2015-01-01

    Using a multiple case study methodology, interviews were conducted to examine current practices and perceptions of the communication practices of teachers working with high school students with emotional and behavioral disorders (EBD). These interviews involved questions about general communication instances which occurred each week, communication…

  13. Relationships of Aggression Subtypes and Peer Status among Aggressive Boys in General Education and Emotional/Behavioral Disorder (EBD) Classrooms

    Science.gov (United States)

    Useche, Ana Carolina; Sullivan, Amanda L.; Merk, Welmoet; Orobio de Castro, Bram

    2014-01-01

    This study examines the concurrent and longitudinal relationships between reactive and proactive aggression and children's peer status. Participants were 94 Dutch elementary school-aged boys in self-contained special education classrooms for students with emotional/behavioral disorders (EBD) and 47 boys with no disabilities in general education…

  14. Cost Effectiveness of the Instrumentalism in Occupational Therapy (IOT) Conceptual Model as a Guide for Intervention with Adolescents with Emotional and Behavioral Disorders (EBD)

    Science.gov (United States)

    Ikiugu, Moses N.; Anderson, Lynne

    2007-01-01

    The purpose of this paper was to demonstrate the cost-effectiveness of using the Instrumentalism in Occupational Therapy (IOT) conceptual practice model as a guide for intervention to assist teenagers with emotional and behavioral disorders (EBD) transition successfully into adulthood. The cost effectiveness analysis was based on a project…

  15. The "B" in EBD Is Not Just for Bullying

    Science.gov (United States)

    Kauffman, James M.

    2015-01-01

    Problems in defining emotional and behavioural difficulties of all types, including bullying, are discussed. Interactions among seeing, naming and communicating about these phenomena are considered. School and community characteristics of students with emotional and behavioural difficulties are touched upon. Major problems in definition and…

  16. Reintegrating Elementary Students with EBD from Alternative Placement to Public School

    Science.gov (United States)

    Avery-Sterud, Barbara

    2009-01-01

    Significant numbers of children with emotional and behavioral disorders receive services in settings other than general education, but it is expected they will return to a less restrictive environment. Reintegrating these students once they have completed treatment is a significant problem. Students can demonstrate improved behavior and…

  17. Four Supportive Pillars in Career Exploration and Development for Adolescents with LD and EBD

    Science.gov (United States)

    Trainor, Audrey A.; Smith, Shane Anthony; Kim, Sunyoung

    2012-01-01

    In addition to typical career development and vocational programs in general education, providing school-based programs that are directly linked to employment and career development for youth with learning and emotional and behavioral disabilities is a legally mandated service in special education. Several broad research-based strategies are…

  18. Classwide PBIS for Students with EBD: Initial Evaluation of an Integrity Tool

    Science.gov (United States)

    Jeffrey, Jennifer L.; McCurdy, Barry L.; Ewing, Sam; Polis, Dustin

    2009-01-01

    The purpose of this pilot project was to develop a tool and a process for providing performance feedback on evidence-based classroom management strategies to teachers of students in emotional support classrooms. The project was carried out with nine classroom teachers and descriptive results are discussed. Initial results found increases in…

  19. Considerations for the Placement of Youth with EBD in Alternative Education Programs

    Science.gov (United States)

    Atkins, Trent; Bartuska, Jamie

    2010-01-01

    Alternative education programs (also called alternative schools) first appeared on the American landscape in the 1960s. Despite the proliferation of these programs, a generic description of what constitutes an alternative education program, historically, has been elusive. Most alternative education programs have the general criteria of serving…

  20. Introduction to The Special Issue: Cognitive-Behavioral Interventions with Students with EBD

    Science.gov (United States)

    Mayer, Matthew; Lochman, John; Van Acker, Richard

    2005-01-01

    Significant progress has been made in developing models of social information processing, and cognitive-behavioral processes and related interventions. While there has been limited attention to cognitive-behavioral modification (CBM) in the special education literature, the majority of the contributions have come from the fields of school,…

  1. Systematic academic instruction for students with EBD: the construction and use of a tool for teachers

    NARCIS (Netherlands)

    Worp-van der Kamp, van der; Pijl, Sip Jan; Post, Wendy J.; Bijstra, Jan O.; Bosch, Els J. van der

    2015-01-01

    Educating students with behavioural, emotional and social difficulties requires a thorough systematic approach with the focus on academic instruction. This study addresses the development of a tool, consisting of two questionnaires, for measuring systematic academic instruction. The questionnaires c

  2. Using Reliable Change to Calculate Clinically Significant Progress in Children with EBD: A BHRS Program Evaluation

    Science.gov (United States)

    Thoder, Vincent J.; Hesky, James G.; Cautilli, Joseph D.

    2010-01-01

    Children often have complex emotional and behavioral disorders (ADHD, ODD, Depression, PTSD, etc.). A large amount of research exists in the behavioral treatment of children with these disorders regarding specific behavioral problems. Much less research exists for the treatment of comprehensive problematic behaviors that these children experience…

  3. A Meta-Analysis of Video-Modeling Based Interventions for Reduction of Challenging Behaviors for Students with EBD

    Science.gov (United States)

    Losinski, Mickey; Wiseman, Nicole; White, Sherry A.; Balluch, Felicity

    2016-01-01

    The current study examined the use of video modeling (VM)-based interventions to reduce the challenging behaviors of students with emotional or behavioral disorders. Each study was evaluated using Council for Exceptional Children's (CEC's) quality indicators for evidence-based practices. In addition, study effects were calculated along the three…

  4. Examination of the Relationship between Teacher Praise and Opportunities for Students with EBD To Respond to Academic Requests.

    Science.gov (United States)

    Sutherland, Kevin S.; Wehby, Joseph H.; Yoder, Paul J.

    2002-01-01

    This study examined the relationship between opportunities to respond (OTR) to academic requests and teacher praise in 20 classrooms for students with emotional and/or behavior disorders using time-window sequential analysis. Results suggest that: (1) a summary-level relationship represented by a significant positive correlation and (2) a…

  5. Classwide Teacher Implementation of Self-Regulated Strategy Development for Writing with Students with E/BD in a Residential Facility

    Science.gov (United States)

    Ennis, Robin Parks; Jolivette, Kristine; Terry, Nicole Patton; Fredrick, Laura D.; Alberto, Paul A.

    2015-01-01

    One promising intervention to support the writing skills of students with and at risk for emotional and behavioral disorders is self-regulated strategy development (SRSD). The purpose of this study was to extend this line of inquiry to a residential setting with teachers serving as interventionists and determine the effects of the SRSD using the…

  6. Supporting Early Adolescent Learning and Social Strengths: Promoting Productive Contexts for Students At-Risk for EBD during the Transition to Middle School

    Science.gov (United States)

    Farmer, Thomas W.; Hamm, Jill V.; Petrin, Robert A.; Robertson, Dylan; Murray, Robert A.; Meece, Judith L.; Brooks, Debbie Sprott

    2010-01-01

    This study involved a pilot examination of the impact of the Supporting Early Adolescent Learning and Social Strengths (SEALS) model on the 6th grade academic and social context following the transition to middle school. Two middle schools from a high poverty Appalachian school district were randomly assigned to the intervention and control…

  7. Pragmatic language and the child with emotional/behavioural difficulties (EBD): a pilot study exploring the interaction between behaviour and communication disability.

    Science.gov (United States)

    Mackie, Leila; Law, James

    2010-01-01

    The relationship between mental health, behaviour and language development is widely recognized in the literature. Recent advances in assessment tools allows one to consider the role of pragmatic language skills in this co-occurrence. This pilot study aimed to investigate (1) the level of association between pragmatic language difficulties and emotional/behavioural difficulties; and (2) what explanations there might there be for any such association. The roles of language, word decoding, and non-verbal cognitive ability and also socio-demographic factors are considered. Seventeen participants aged 7-11 years were identified from Educational Psychologist caseloads as having behaviour that is causing concern at school. Comparisons were made with 16 age- and sex-matched controls. Participants' language, literacy and non-verbal cognitive ability were assessed at school. Parents and teachers completed questionnaires investigating communication skills, behaviour and emotional wellbeing. No significant difference was found between the groups for non-verbal cognitive ability. However, children in the referred group were significantly more likely to have structural language, word decoding and pragmatic language difficulties and mothers with no further education beyond school. Taking a broad view of language skills to include structural language, pragmatic language and word decoding, 94% (n = 15) of referred children had significant difficulties with at least one of these three factors. The only factor not found on its own was structural language difficulties, indicating that on their own they are perhaps not associated with emotional/behavioural difficulties. The results of this pilot study have implications for how we view language and behaviour difficulties in primary schools. Future larger-scale research should consider the role of parenting factors, pragmatic language skills and literacy ability in the high co-existence rate of emotional/behavioural difficulties and language/communication needs.

  8. Effects of Sentence Instruction and Frequency Building to a Performance Criterion on Elementary-Aged Students with Behavioral Concerns and EBD

    Science.gov (United States)

    Datchuk, Shawn M.; Kubina, Richard M.; Mason, Linda H.

    2015-01-01

    Elementary-aged students with behavioral concerns and disabilities struggling to construct sentences stand a high likelihood for continued academic difficulty. Several studies have used sentence instruction with picture-word prompts to improve sentence level writing skills, including construction of simple sentences, syntax, capitalization, and…

  9. Pragmatic Language and the Child with Emotional/Behavioural Difficulties (EBD): A Pilot Study Exploring the Interaction between Behaviour and Communication Disability

    Science.gov (United States)

    Mackie, Leila; Law, James

    2010-01-01

    Introduction: The relationship between mental health, behaviour and language development is widely recognized in the literature. Recent advances in assessment tools allows one to consider the role of pragmatic language skills in this co-occurrence. Aims: This pilot study aimed to investigate (1) the level of association between pragmatic language…

  10. Pragmatic Language and the Child with Emotional/Behavioural Difficulties (EBD): A Pilot Study Exploring the Interaction between Behaviour and Communication Disability

    Science.gov (United States)

    Mackie, Leila; Law, James

    2010-01-01

    Introduction: The relationship between mental health, behaviour and language development is widely recognized in the literature. Recent advances in assessment tools allows one to consider the role of pragmatic language skills in this co-occurrence. Aims: This pilot study aimed to investigate (1) the level of association between pragmatic language…

  11. Eb&D: A new clustering approach for signed social networks based on both edge-betweenness centrality and density of subgraphs

    Science.gov (United States)

    Qi, Xingqin; Song, Huimin; Wu, Jianliang; Fuller, Edgar; Luo, Rong; Zhang, Cun-Quan

    2017-09-01

    Clustering algorithms for unsigned social networks which have only positive edges have been studied intensively. However, when a network has like/dislike, love/hate, respect/disrespect, or trust/distrust relationships, unsigned social networks with only positive edges are inadequate. Thus we model such kind of networks as signed networks which can have both negative and positive edges. Detecting the cluster structures of signed networks is much harder than for unsigned networks, because it not only requires that positive edges within clusters are as many as possible, but also requires that negative edges between clusters are as many as possible. Currently, we have few clustering algorithms for signed networks, and most of them requires the number of final clusters as an input while it is actually hard to predict beforehand. In this paper, we will propose a novel clustering algorithm called Eb &D for signed networks, where both the betweenness of edges and the density of subgraphs are used to detect cluster structures. A hierarchically nested system will be constructed to illustrate the inclusion relationships of clusters. To show the validity and efficiency of Eb &D, we test it on several classical social networks and also hundreds of synthetic data sets, and all obtain better results compared with other methods. The biggest advantage of Eb &D compared with other methods is that the number of clusters do not need to be known prior.

  12. Do Adolescents with Emotional and Behavioral Disturbances Attending Schools for Special Education Have Lower Expectations Regarding the Transition to Adulthood?

    Science.gov (United States)

    Margraf, Hannah; Pinquart, Martin

    2016-01-01

    Individuals with emotional and behavioral disturbances (EBD) and those attending special schools tend to have poorer adult outcomes than adolescents without EBD and peers from regular schools. Using a four-group comparison (students with or without EBD from special schools and students with or without EBD from regular schools), the present study…

  13. Characteristics of Successful Teachers of Students with Emotional Behavioral Disabilities: Teacher and Expert Perceptions

    Science.gov (United States)

    Delport, John

    2012-01-01

    This study used a mixed methods design to examine the characteristics--including competencies (i.e., knowledge and skills), and personal attributes--of successful teachers of students with E/BD. The characteristics were examined through the perceptions of teachers of students with E/BD (teachers who are expert in E/BD, n = 14, MEd Graduates…

  14. Balloon Dilatation for Corrosive Esophageal Strictures in Children: Radiologic and Clinical Outcomes

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    Youn, Byung Jae; Kim, Woo Sun; Cheon, Jung Eun; Kim, Wha Young; Shin, Su Mi; Kim, In One; Yeon, Kyung Mo [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2010-04-15

    We retrospectively evaluated the effectiveness of the esophageal balloon dilatation (EBD) in children with a corrosive esophageal stricture. The study subjects included 14 patients (M:F = 8:6, age range: 17-85 months) who underwent an EBD due to a corrosive esophageal stricture. The causative agents for the condition were glacial acetic acid (n = 9) and lye (n = 5). A total of 52 EBD sessions were performed in 14 patients (range 1-8 sessions). During the mean 15-month follow-up period (range 1-79 months), 12 patients (86%) underwent additional EBD due to recurrent esophageal stricture. Dysphagia improved after each EBD session and oral feeding was possible between EBD sessions. Long-term success (defined as dysphagia relief for at least 12 months after the last EBD) was achieved in two patients (14%). Temporary success of EBD (defined as dysphagia relief for at least one month after the EBD session) was achieved in 17 out of 52 sessions (33%). A submucosal tear of the esophagus was observed in two (4%) sessions of EBD. Only a limited number of children with corrosive esophageal strictures were considered cured by EBD. However, the outcome of repeated EBD was sufficient to allow the children to eat per os prior to surgical management.

  15. Librarians' roles in evidence-based dentistry education: a review of literature and a survey in North America.

    Science.gov (United States)

    Gu, Xiao-Mei

    2010-10-01

    This study describes the current roles of dental librarians in Evidence-based Dentistry (EBD) education including their perceptions of EBD and barriers to their involvement. A Web-based survey was distributed to the dental librarians in North America, with a 71% response rate. The results showed that the majority of dental librarians are playing multiple and diverse roles in EBD education. The most frequently cited barrier to their involvement is the low level of interest from the dental faculty/student/school. Most dental librarians felt competent in supporting EBD, although continuing education needs in both EBD and teaching skills were pointed out.

  16. Perceptions and practices of dental school faculty regarding evidence-based dentistry.

    Science.gov (United States)

    Marshall, Teresa A; Straub-Morarend, Cheryl L; Qian, Fang; Finkelstein, Michael W

    2013-02-01

    Successful integration of critical thinking and evidence-based dentistry (EBD) concepts throughout didactic and clinical dental curricula require faculty support. Critical thinking and EBD definitions and practice continue to evolve, and not all dental faculty members were exposed to such concepts during their education. The objective of this study was to understand faculty members' perspectives on both critical thinking and EBD. An online survey was designed to assess full- and part-time faculty members' understanding, practice and teaching of critical thinking and EBD, interest in and perceived significance of EBD, and perceived barriers to teaching critical thinking and EBD at one U.S. dental school. Forty-three faculty members completed the survey for a 41 percent response rate. Most respondents (46 percent) defined critical thinking as the use of evidence or the scientific method in decision making and EBD as clinical practice based on "science only" (39 percent) or "quality science only" (34 percent). Based on their individual definitions, over 75 percent of the respondents reported incorporating critical thinking into didactic and clinical teaching; 79 percent and 47 percent, respectively, reported incorporating EBD into their didactic and clinical teaching. While these faculty members confirmed the importance of teaching students EBD, they identified barriers to teaching as time, knowledge, and resources. These results, which reflect one school's efforts to understand faculty perceptions and practices of EBD, suggest that faculty training and resource support are necessary for successful curricular integration of critical thinking and EBD.

  17. Eco-effective design and evidence-based design: perceived synergy and conflict.

    Science.gov (United States)

    Shepley, Mardelle McCuskey; Baum, Mara; Ginsberg, Rachel; Rostenberg, Bill

    2009-01-01

    Eco-effective design (EED) and evidence-based design (EBD) are two powerful trends currently shaping healthcare architecture. EED addresses whether/how the design and operation of buildings improve ecological value and enhance human health. EBD addresses whether/how the design and operation of buildings support positive health outcomes in the built environment through a growing collection of solutions informed by research and practical knowledge. The primary hypothesis of this study was that EBD and EED are compatible approaches to health facility design, especially when addressing the impact of the environment on human health. To explore this hypothesis, healthcare facility administrators were surveyed regarding their perceptions of the relationship between EED and EBD. Input from focus groups and EED and EBD experts was used to formulate the administrator questionnaire. The study concluded that the relationship between EED and EBD typically was synergistic.

  18. The right hepatic artery syndrome

    Institute of Scientific and Technical Information of China (English)

    Kazumi Miyashita; Katsuya Shiraki; Takeshi Ito; Hiroki Taoka; Takeshi Nakano

    2005-01-01

    Various benign and malignant conditions could cause biliary obstruction. Compression of extrahepatic bile duct (EBD) by right hepatic artery was reported as a right hepatic artery syndrome but all cases were compressed EBD from stomach side. Our case compressed from dorsum was not yet reported, so it was thought to be a very rare case. We present here the first case of bile duct obstruction due to the compression of EBD from dorsum by right hepatic artery.

  19. Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM

    Science.gov (United States)

    Offidani, Massimo; Pégourie, Brigitte; De La Rubia, Javier; Garderet, Laurent; Laribi, Kamel; Bosi, Alberto; Marasca, Roberto; Laubach, Jacob; Mohrbacher, Ann; Carella, Angelo Michele; Singhal, Anil K.; Tsao, L. Claire; Lynch, Mark; Bleickardt, Eric; Jou, Ying-Ming; Robbins, Michael; Palumbo, Antonio

    2016-01-01

    In this proof-of-concept, open-label, phase 2 study, patients with relapsed/refractory multiple myeloma (RRMM) received elotuzumab with bortezomib and dexamethasone (EBd) or bortezomib and dexamethasone (Bd) until disease progression/unacceptable toxicity. Primary endpoint was progression-free survival (PFS); secondary/exploratory endpoints included overall response rate (ORR) and overall survival (OS). Two-sided 0.30 significance level was specified (80% power, 103 events) to detect hazard ratio (HR) of 0.69. Efficacy and safety analyses were performed on all randomized patients and all treated patients, respectively. Of 152 randomized patients (77 EBd, 75 Bd), 150 were treated (75 EBd, 75 Bd). PFS was greater with EBd vs Bd (HR, 0.72; 70% confidence interval [CI], 0.59-0.88; stratified log-rank P = .09); median PFS was longer with EBd (9.7 months) vs Bd (6.9 months). In an updated analysis, EBd-treated patients homozygous for the high-affinity FcγRIIIa allele had median PFS of 22.3 months vs 9.8 months in EBd-treated patients homozygous for the low-affinity allele. ORR was 66% (EBd) vs 63% (Bd). Very good partial response or better occurred in 36% of patients (EBd) vs 27% (Bd). Early OS results, based on 40 deaths, revealed an HR of 0.61 (70% CI, 0.43-0.85). To date, 60 deaths have occurred (28 EBd, 32 Bd). No additional clinically significant adverse events occurred with EBd vs Bd. Grade 1/2 infusion reaction rate was low (5% EBd) and mitigated with premedication. In patients with RRMM, elotuzumab, an immunostimulatory antibody, appears to provide clinical benefit without added clinically significant toxicity when combined with Bd vs Bd alone. Registered to ClinicalTrials.gov as NCT01478048. PMID:27091875

  20. Effects of a Summarizing Strategy on Written Summaries of Children with Emotional and Behavioral Disorders

    Science.gov (United States)

    Saddler, Bruce; Asaro-Saddler, Kristie; Moeyaert, Mariola; Ellis-Robinson, Tammy

    2017-01-01

    In this single-subject study, we examined the effects of a summarizing strategy on the written summaries of children with emotional and behavioral disorders (EBDs). Six students with EBDs in fifth and sixth grades learned a mnemonic-based strategy for summarizing taught through the self-regulated strategy development (SRSD) approach. Visual…

  1. The Effects of Self-Regulation Strategy Development on Written Expression of Students with Emotional/Behavioral Disabilities

    Science.gov (United States)

    Pannell, Ronald Howard

    2012-01-01

    This investigation examined the effects of self-regulated strategy development (SRSD) on the written expression of students with emotional and behavioral disabilities (EBD). The target students for this study were elementary students who receive special education services under the category of EBD. An AB Multiple Baseline Design (i.e., Baseline,…

  2. Lessons Learned from Implementing Self-Regulated Strategy Development with Students with Emotional and Behavioral Disorders in Alternative Educational Settings

    Science.gov (United States)

    Ennis, Robin Parks; Harris, Karen R.; Lane, Kathleen Lynne; Mason, Linda H.

    2014-01-01

    Self-regulated strategy development (SRSD) is an evidence-based intervention for use with students with emotional and behavioral disorders (EBD). To date, there are nine studies investigating SRSD in alternative education settings, including self-contained day and residential schools, with 113 students with EBD in grades 3 through 12. A brief…

  3. Existing Research and Future Directions for Self-Regulated Strategy Development with Students with and at Risk for Emotional and Behavioral Disorders

    Science.gov (United States)

    Ennis, Robin Parks; Jolivette, Kristine

    2014-01-01

    Students with emotional and behavioral disorders (E/BD) have academic deficits that affect their success in school. However, there are few research studies investigating what strategies work best for this population, especially in the area of writing. One promising intervention to support the writing skills of students with and at risk for E/BD is…

  4. Self-Regulated Strategy Development for Students with Emotional/Behavioral Disorders in a Residential School

    Science.gov (United States)

    Ennis, Robin Parks

    2013-01-01

    Students with emotional and behavioral disorders (E/BD) have academic deficits that affect their success in school; however, few researchers have investigated what strategies work best for this population, especially in the area of writing. One promising intervention to support the writing skills of students with and at-risk for E/BD is…

  5. Application of an efficient Bayesian discretization method to biomedical data

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    Gopalakrishnan Vanathi

    2011-07-01

    Full Text Available Abstract Background Several data mining methods require data that are discrete, and other methods often perform better with discrete data. We introduce an efficient Bayesian discretization (EBD method for optimal discretization of variables that runs efficiently on high-dimensional biomedical datasets. The EBD method consists of two components, namely, a Bayesian score to evaluate discretizations and a dynamic programming search procedure to efficiently search the space of possible discretizations. We compared the performance of EBD to Fayyad and Irani's (FI discretization method, which is commonly used for discretization. Results On 24 biomedical datasets obtained from high-throughput transcriptomic and proteomic studies, the classification performances of the C4.5 classifier and the naïve Bayes classifier were statistically significantly better when the predictor variables were discretized using EBD over FI. EBD was statistically significantly more stable to the variability of the datasets than FI. However, EBD was less robust, though not statistically significantly so, than FI and produced slightly more complex discretizations than FI. Conclusions On a range of biomedical datasets, a Bayesian discretization method (EBD yielded better classification performance and stability but was less robust than the widely used FI discretization method. The EBD discretization method is easy to implement, permits the incorporation of prior knowledge and belief, and is sufficiently fast for application to high-dimensional data.

  6. Themes and Dimensions of Emotional and Behavioral Disorders

    Science.gov (United States)

    Mustian, April L.; Cuenca-Sanchez, Yojanna

    2012-01-01

    Students with emotional and behavioral disorders (EBD) are one of the most underserved populations in today's schools (Kauffman, Mock, & Simpson, 2011). Many of these students also have additional disabilities in conjunction with an EBD identification, such as Learning Disabilities (LD), Attention Deficit Disorder (ADD), Attention Deficit…

  7. Investigation of a Multi-Component Intervention Addressing Mathematical Reasoning and Self-Regulation of Behavior for Students with Emotional/Behavioral Disabilities

    Science.gov (United States)

    Fisher, Marie B.

    2013-01-01

    For students with Emotional/Behavioral Disabilities (EBD), negative student outcomes are the poorest across disability categories, including high rates of school dropouts, unemployment and incarcerations. Mathematically, students with EBD receiving instruction in special education settings experience practices not consistent with recommendations…

  8. Self-Regulated Strategy Development for Students with Emotional/Behavioral Disorders in a Residential School

    Science.gov (United States)

    Ennis, Robin Parks

    2013-01-01

    Students with emotional and behavioral disorders (E/BD) have academic deficits that affect their success in school; however, few researchers have investigated what strategies work best for this population, especially in the area of writing. One promising intervention to support the writing skills of students with and at-risk for E/BD is…

  9. Severity of Academic Achievement and Social Skills Deficits

    Science.gov (United States)

    Bloom, Elana L.; Karagiannakis, Anastasia; Toste, Jessica R.; Heath, Nancy L.; Konstantinopoulos, Effie

    2007-01-01

    This study explored the differences in the rated social skills of elementary-aged students at-risk for emotional/behavioural disorders (E/BD) based on severity of academic difficulties. Teachers nominated students at-risk for E/BD who were classified into four groups of academic difficulty based on the Wide Range Achievement Test-3. Students,…

  10. Struggling Readers with Emotional and Behavioral Disorders and Their Teachers: Perceptions of Corrective Reading

    Science.gov (United States)

    McDaniel, Sara C.; Duchaine, Ellen L.; Jolivette, Kristine

    2010-01-01

    Students with emotional and behavioral disorders (E/BD) experience deficits in social, behavioral, and academic areas. Of great importance in the academic area is reading achievement. Students with E/BD who struggle with reading tend to have negative in-school and post-school outcomes. Due to the severity of potential outcomes, it is essential to…

  11. Academic Instruction and Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Hagaman, Jessica L.

    2012-01-01

    Students with emotional and behavioral disorders (EBD) are known to experience academic deficits across core subject areas such as reading and mathematics. Until recently, less attention had been paid to the academic deficits of students with EBD. This was due, in part, to a common belief that academic deficits could not be addressed until problem…

  12. Strategies and Procedures for Designing Proactive Interventions with a Culturally Diverse Population of Students with Emotional or Behavioral Disorders and Their Families/Caregivers. Fourth CCBD Mini-Library Series: Addressing the Diverse Needs of Children and Youth with Emotional/Behavioral Disorders--Programs That Work.

    Science.gov (United States)

    Campbell-Whatley, Gloria D.; Gardner, Ralph, III

    This monograph examines the special problems of students with emotional/behavioral disorders (E/BD) who are from culturally diverse backgrounds and offers strategies for designing appropriate interventions. In the introductory chapter, the student demographics in the E/BD category of special education are reviewed and efforts of one state,…

  13. Constant Time Delay: One Way to Provide Positive Behavioral Support for Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Stevens, Kay B.; Lingo, Amy S.

    2005-01-01

    Teachers of students with emotional and behavioral disorders (EBD) understand conceptually, emotionally, and legally the importance of using research-based procedures as well as positive behavioral supports. One way to provide positive behavioral support for students with EBD is constant time delay (CTD). CTD is an instructional delivery procedure…

  14. Existing Research and Future Directions for Self-Regulated Strategy Development with Students with and at Risk for Emotional and Behavioral Disorders

    Science.gov (United States)

    Ennis, Robin Parks; Jolivette, Kristine

    2014-01-01

    Students with emotional and behavioral disorders (E/BD) have academic deficits that affect their success in school. However, there are few research studies investigating what strategies work best for this population, especially in the area of writing. One promising intervention to support the writing skills of students with and at risk for E/BD is…

  15. The Influence of Professional Development for Special Education Teachers: Self-Regulated Strategy Development in Writing for Students with Emotional Behavioral Disorders

    Science.gov (United States)

    Liberty, Lisa M.

    2013-01-01

    Students with emotional behavioral disorders (EBD) are well known for their challenging, demanding, unpredictable, and difficult behaviors. Many students with EBD exhibit significant academic deficits, especially in writing. Writing instruction is challenging for teachers because they lack knowledge of the writing process, strategies, and…

  16. Defining Administrative Support and Its Relationship to the Attrition of Teachers of Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Cancio, Edward J.; Albrecht, Susan Fread; Johns, Beverley H.

    2013-01-01

    Special education faces serious shortages of teachers, and the area of special education teaching with the greatest shortage is in the field emotional and behavioral disorders (EBD). This study was conducted to identify the perceptions of current teachers of students with EBD on the definition of and the extent and importance of administrative…

  17. Effective Teachers for Students with Emotional/Behavioral Disorders: Active Ingredients Leading to Positive Teacher and Student Outcomes

    Science.gov (United States)

    Conroy, Maureen A.; Sutherland, Kevin S.

    2012-01-01

    Teachers of students with emotional/behavioral disorders (E/BD) have varied skills and abilities. Within the field there are some teachers, who teach students with E/BD by actively engaging them in learning tasks and who have few behavior problems in comparison to other teachers, who struggle with classroom management. Many researchers have found…

  18. Difficulties Associated with the Coding and Categorization of Students with Emotional and Behavioural Disabilities in Alberta

    Science.gov (United States)

    Wishart, Diane; Jahnukainen, Markku

    2010-01-01

    In Canada, there is a recent trend toward non-categorization of services of students with emotional and behavioural disabilities (EBD). Yet in Alberta, the coding of students with EBD provides opportunities to diagnose students' learning difficulties but is hindered in this process, in large part, by being tied into special needs funding. Current…

  19. How We Might Make Special Education for Students with Emotional or Behavioral Disorders Less Stigmatizing

    Science.gov (United States)

    Kauffman, James M.; Badar, Jeanmarie

    2013-01-01

    The authors note that identification as having emotional or behavioral disorders (EBD) is generally acknowledged to be stigmatizing. The stigma associated with identification as needing special education for EBD (or any other disability) could be reduced by talking in readily understood language about differences, accepting the reality of…

  20. The Fight Free Classroom.

    Science.gov (United States)

    Whedon, Craig K.; Bakken, Jeffrey P.; Fletcher, Reginald

    2000-01-01

    Describes implementation of the Fight Free Classroom intervention (designed to decrease fighting and aggressiveness by helping students take ownership of their behavior) in an urban elementary school that included students with emotional and behavioral disorders (EBD). Overall, aggressive acts among students with and without EBD decreased…

  1. Awareness, knowledge and practice of evidence-based dentistry amongst dentists in Kuwait.

    Science.gov (United States)

    Haron, I M; Sabti, M Y; Omar, R

    2012-02-01

    This study assessed the awareness, knowledge and practice of evidence-based dentistry (EBD) amongst dentists working in the public sector in Kuwait. Of the 150 randomly selected dentists from all five health districts in Kuwait who had originally been approached, 120 participated by completing a pre-tested, self-administered questionnaire (80% response rate). Whereas 60.9% of the group stated that they practice EBD most of the time, fewer (40.8%) had a reasonable understanding of EBD based upon tested knowledge scores of EBD-related topics. Clinical decisions appeared to be mostly based on the clinician's own judgment (73.3%) rather than on evidence-based sources such as PubMed (28.3%) or the Cochrane Library (6.7%). A number of within-group differences were noted, with women (Pevidence-based sources to remove some of the possible barriers to implementation of EBD.

  2. The winds of change revisited: progress towards building a culture of evidence-based dentistry.

    Science.gov (United States)

    Hinton, Robert J; McCann, Ann L; Schneiderman, Emet D; Dechow, Paul C

    2015-05-01

    In 2008, Texas A&M University Baylor College of Dentistry launched a comprehensive four-year curriculum in evidence-based dentistry (EBD) along with a series of faculty development initiatives to create an EBD culture. The aim of this study was to determine the institution's success in achieving this goal. The assessment tool used was the PEAK instrument, which measures respondents' EBD Practices, Experience, Attitudes, and Knowledge. Two EBD-trained classes of students and one class untrained in EBD (approximately 100 students in each class) were assessed annually. The faculty were assessed before and after completion of the initiative. Nearly all students responded, with samples ranging from 87 to 102; the faculty response rates were 53% (62/117) in 2009 and 66% in 2013 (81/123). In the results, the trained students scored significantly higher in knowledge than the untrained students at each of the first three PEAK administrations (p≤0.001). Regarding confidence in appraising a research report, the first trained group significantly gained in appropriate use of statistical tests (pdentistry (p<0.001). Faculty comfort level with reading peer-reviewed articles increased significantly from 2009 to 2013 (p=0.039). Faculty members who participated in the summer EBD Fundamentals course (n=28) had significantly higher EBD knowledge scores than those who did not participate (p=0.013), and their EBD attitudes and practices were more positive (p<0.05). Students and faculty trained in EBD were more knowledgeable and exhibited more positive attitudes, supporting a conclusion that the college has made substantial progress towards achieving an EBD culture.

  3. Evidence-based dentistry for you and me. The challenge of using a new educational tool.

    Science.gov (United States)

    Moskowitz, Elliott M

    2009-11-01

    Evidence-based dentistry (EBD) is a relatively new term in the dental profession. EBD has been the center of intense interest, discussion, confusion and concern for academics, dental practitioners and other interested health care communities. The term implies that sound, evidentially based information will help the clinician improve treatment outcomes in a more consistent and predictable manner. How does this new model of education differ from previous models? And how can the clinician use this new model in an effective and practical manner? There seems to be a number of questions about EBD that remain insufficiently answered. EBD demands that the dental practitioner become the premier educated consumer of relevant information. Accessing, appraising and applying new clinical information are key elements of the EBD process. While many colleagues embrace potential opportunities that dentistry might enjoy as a result of the judicious use of EBD, others have raised concerns about the possible misuse of such information that might be inappropriately interpreted to the detriment of the individual patient and dental profession. Clearly, EBD is a potentially powerful informational tool that must be used cautiously and wisely.

  4. Arabidopsis CDS blastp result: AK241795 [KOME

    Lifescience Database Archive (English)

    Full Text Available B from Staphylococcus aureus [GI:14020985]; T20K24.13 has been merged with T20K24.12 per suggestion of Dr. Kristian Axelsen (このメールアドレスはスパムボットから保護されています。閲覧するにはJavaScriptを有効にする必要があります。 document.getElementById('cloak5ebd35c5bdbcce6f50b57257847e6b8c').innerHTML = ''; var prefix = 'ma' + 'il' + 'to'; var path = 'hr' + 'ef' + '='; var addy5ebd35c5bdbcce6f50b57257847e6b8c = 'axe' + '@'; addy5ebd35c5bdbcce6f50b57257847e6b8c = addy5ebd35c5bdbcce6f50b57257847e6b8c + 'biobase' + '.' + 'dk'; var addy_text5ebd35c5bdbcce6f50b57257847e6b8c = 'axe' + '@' + 'biobase' + '.' + 'dk';document.getElementById('cloak5ebd35c5bdbcce6f50b57257847e6b8c').innerHTML += ''+addy_text5ebd35c5bdbcce6f50b57257847e6b8c+''; ) 5e-67 ...

  5. Implementation of evidence-based dentistry into practice: analysis of awareness, perceptions and attitudes of dentists in the World Dental Federation-European Regional Organization zone.

    Science.gov (United States)

    Yamalik, Nermin; Nemli, Secil Karakoca; Carrilho, Eunice; Dianiskova, Simona; Melo, Paulo; Lella, Anna; Trouillet, Joel; Margvelashvili, Vladimer

    2015-06-01

    Based on evidence-based dentistry (EBD) being a relatively new concept in dentistry, the attitudes, perceptions and level of awareness of dentists regarding EBD, and perceived barriers to its implementation into daily practice, were comparatively analysed in six countries of the FDI (World Dental Federation-Federation Dentaire Internationale)-European Regional Organization (ERO) zone (France, Georgia, Poland, Portugal, Slovakia and Turkey). For this purpose, a questionnaire, 'The Relationship Between Dental Practitioners and Universities', was developed by the FDI-ERO Working Group and applied by National Dental Associations (NDAs). A total of 850 valid responses were received, and cumulative data, comparisons between countries and potential impact of demographic variables were analysed. Regarding EBD, similar percentages of respondents reported that they 'know what it is' (32.8%) and 'they practice' (32.1%). Most respondents believed that 'EBD is beneficial' (89.1%); however, they had different thoughts regarding 'who actually benefited from EBD'. Of the participants, 60% believed that 'dentists experience difficulties in implementing EBD'. Although lack of time, lack of education and limited availability of evidence-based clinical guidelines were among the major barriers, there were differences among countries (P<0.05). Significant differences were also observed between countries regarding certain questions such as 'where EBD needed to be taught' (P<0.05), as both undergraduate and continuing education were suggested to be suitable. Age, practice mode and years of practice significantly affected many of the responses (P<0.05). There was a general, positive attitude toward EBD; however, there was also a clear demand for more information and support to enhance dentists' knowledge and use of EBD in everyday practice and a specific role for the NDAs.

  6. Human primordial germ cell-derived progenitors give rise to neurons and glia in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Teng, Yincheng [Department of Gynecology and Obstetrics, The 6th People' s Hospital, School of Medicine, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233 (China); Chen, Bin [Center for Developmental Biology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kong Jiang Road, Shanghai 200092 (China); Tao, Minfang, E-mail: Taomf@126.com [Department of Gynecology and Obstetrics, The 6th People' s Hospital, School of Medicine, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233 (China)

    2009-12-18

    We derived a cell population from cultured human primordial germ cells from early human embryos. The derivates, termed embryoid body-derived (EBD) cells, displayed an extensive capacity for proliferation and expressed a panel of markers in all three germ layers. Interestingly, EBD cells were also positive for markers of neural stem/progenitor cells, such as nestin and glial fibrillary acidic protein. When these cells were transplanted into the brain cavities of fetal sheep and postnatal NOD-SCID mice or nerve-degenerated tibialis anterior muscles, they readily gave rise to neurons or glial cells. To our knowledge, our data are the first to demonstrate that EBD cells can undergo further neurogenesis under suitable environments in vivo. Hence, with the abilities of extensive expansion, self-renewal, and differentiation, EBD cells may provide a useful donor source for neural stem/progenitor cells to be used in cell-replacement therapies for diseases of the nervous system.

  7. Enhanced Brine Dewatering System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of the Enhanced Brine Dewatering System (EBDS) is to provide a scalable means of completely recovering usable water from byproducts created by reverse...

  8. Exploring Self-Concept for Students with Emotional and/or Behavioral Disorders as They Transition from Elementary to Middle School and High School

    Directory of Open Access Journals (Sweden)

    Nicholas A. Gage

    2012-01-01

    Full Text Available Although significant research has been conducted around assessment and intervention for students with emotional and/or behavioral disorders (EBDs, few have investigated specifically how students with EBD self-report on their academic and social competence, or self-concept. Using a national longitudinal database, this study explored how students with EBD reported their self-concept in elementary school, how their reported self-concept changed as they transitioned to middle and high school, and, what factors influenced this change. Using latent growth modeling procedures, the study found that students with EBD reported high self-concept across time and that reported self-concept was most impacted by ethnicity (β=−.174 and urbanicity (β=−.113.

  9. Enhanced Brine Dewatering System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of the Enhanced Brine Dewatering System (EBDS) is to provide an easily scalable means of completely recovering usable water from byproducts created by...

  10. Electronic Brake-Force Distribution Control Methods of ABS-Equipped Vehicles During Cornering Braking

    Institute of Scientific and Technical Information of China (English)

    WANG Guo-ye; LIU Zhao-du; MA Yue-feng; QI Zhi-quan

    2007-01-01

    Based on the dynamics of ABS-equipped vehicles during cornering braking,the electronic brakeforce distribution (EBD) control methods of ABS-equipped vehicles during cornering braking are proposed.According to the dynamics and the tire model under tire adhesion limit,the stability acceptance criteria of vehicles during cornering braking are proposed.According to the stability acceptance criteria and the ABS control,the EBD control methods of ABS-equipped vehicles during cornering braking are implemented by adjusting the threshold values of tires slip independently.The vehicle states during cornering braking at two typical initial velocities of the vehicle are analyzed by the EBD control methods,whose results indicate the EBD control methods can improve the braking performances of the vehicle during cornering braking comparing with the ABS control.

  11. Drowned in information yet starved for knowledge; evidence-based dentistry, what's in it for me?

    Science.gov (United States)

    Gune, Abhijit

    2010-01-01

    A graduate of the ADA Evidence-based Dentistry Champions Conference explains what he has learned about the techniques of EBD literature and literature searches. EBD is the area of overlap among the literature, clinical experience, and patient characteristics. This paper focuses on evidence from the literature. Sources of summarized evidence are mentioned that can be accessed via the Internet, especially those that summarize evidence of the greatest research rigor that have been summarized systematically.

  12. Full-Length Structures of BenM and Two Variants Reveal Different Oligomerization Schemes for LysR-Type Transcriptional Regulators

    Energy Technology Data Exchange (ETDEWEB)

    Ruangprasert, Ajchareeya; Craven, Sarah H.; Neidle, Ellen L.; Momany, Cory (Georgia)

    2010-11-30

    BenM, a LysR-type transcriptional regulator (LTTR) from the bacterium Acinetobacter baylyi, responds synergistically to benzoate and cis,cis-muconate. With these effectors, BenM activates gene expression during benzoate consumption. Without effectors, BenM represses transcription. Here, X-ray crystallography was used to determine the full-length structures of BenM and two variants that activate transcription without benzoate or cis,cis-muconate: BenM(R156H) and BenM(E226K). Previous studies indicate that these regulators function as tetramers. Here, interconnections between subunits in the crystals prevented the formation of a closed oligomer and highlighted the inherent flexibility of this multidomain regulator. Nevertheless, analysis of subunit interfaces suggested the functional significance of key interactions. The structures of BenM and its variants were nearly identical, implying that transcriptional differences rely on factors beyond major conformational changes defined solely by sequence. Comparisons of BenM with other LTTRs, including unpublished structures in the Protein Data Bank, revealed extensive variation in the relative orientations of DNA-binding domains (DBDs) and effector-binding domains (EBDs). To form dimers, different LTTRs used similar interfaces between two EBDs, each containing two subdomains: EBD-I and EBD-II. Surprisingly, the dimers used three substantially different schemes to form higher-order oligomers. In one scheme used by BenM, oligomer assembly involved contacts between the EBD-II regions and the DBD regions of adjacent subunits. In another scheme, there were no contacts between the EBDs; only the DBDs were involved in tetramer formation. In the third scheme, the oligomer interface involved DBD and EBD-I/EBD-II contacts. These diverse schemes demonstrate novel variation in the oligomeric structures of individual LTTRs within this large and important family.

  13. AcEST: DK960973 [AcEST

    Lifescience Database Archive (English)

    Full Text Available s: (bits) Value tr|B6EBD6|B6EBD6_SOYBN Heat shock protein 90-2 OS=Glycine max PE... 199 9e-50 tr|Q8GT83|Q8GT83_GOSBA Fiber...0 >tr|Q8GT83|Q8GT83_GOSBA Fiber protein Fb9 (Fragment) OS=Gossypium barbadense PE=2 SV=1 Length = 176 Score

  14. AcEST: DK958269 [AcEST

    Lifescience Database Archive (English)

    Full Text Available t alignments: (bits) Value tr|B6EBD6|B6EBD6_SOYBN Heat shock protein 90-2 OS=Glycine max PE... 130 3e-29 tr|Q8GT83|Q8GT83_GOSBA Fiber...LSIDEDAGEA--DADMPPLEDADADAEGSKMEEVD 700 >tr|Q8GT83|Q8GT83_GOSBA Fiber protein Fb9 (Fragment) OS=Gossypium ba

  15. Integrating critical thinking and evidence-based dentistry across a four-year dental curriculum: a model for independent learning.

    Science.gov (United States)

    Marshall, Teresa A; Straub-Morarend, Cheryl L; Handoo, Nidhi; Solow, Catherine M; Cunningham-Ford, Marsha A; Finkelstein, Michael W

    2014-03-01

    Introducing critical thinking and evidence-based dentistry (EBD) content into an established dental curriculum can be a difficult and challenging process. Over the past three years, the University of Iowa College of Dentistry has developed and implemented a progressive four-year integrated critical thinking and EBD curriculum. The objective of this article is to describe the development and implementation process to make it available as a model for other dental schools contemplating introduction of critical thinking and EBD into their curricula. The newly designed curriculum built upon an existing problem-based learning foundation, which introduces critical thinking and the scientific literature in the D1 year, in order to expose students to the rationale and resources for practicing EBD in the D2 and D3 years and provide opportunities to practice critical thinking and apply the EBD five-step process in the D2, D3, and D4 years. All curricular content is online, and D3 and D4 EBD activities are integrated within existing clinical responsibilities. The curricular content, student resources, and student activities are described.

  16. DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.

    Science.gov (United States)

    Zhang, Pan-Pan; Wen, Ying; An, Jing; Yu, Ying-Xin; Wu, Ming-Hong; Zhang, Xin-Yu

    2012-09-18

    1,3-Butadiene (BD) is a carcinogenic air pollutant. Its bioactivation produces four major metabolites, i.e., 3,4-epoxy-1-butene (EB), 3,4-epoxy-1,2-butanediol (EBD), 1,2,3,4-diepoxybutane (DEB), and 3-butene-1,2-diol (BDD). Studies have been mostly focused on DEB due to its strong mutagenicity/carcinogenicity. In contrast, studies of genotoxicity of EB, EBD, and BDD have been limited. In particular, genotoxicity of EBD and BDD using strand breaks as the endpoint has not been investigated. To obtain a more complete understanding of BD toxicity, in the present study, we used comet assay to investigate DNA damage induced by EB, EBD, and BDD in human hepatocyte L02 cells, with the aim to determine their relative potencies, the types of DNA damage, and the possible pathway to form strand breaks. Using alkaline comet assay (pH>13), it was observed that EB and EBD caused similar concentration-dependent increases in DNA migration from 50 to 1000μM. However, BDD induced a statistically significant increase only at 1000μM, and the increase itself was very small. EBD was as potent as EB at lower concentrations (≤200μM), and was slightly less potent than EB at higher concentrations. The results indicated that these metabolites could generate strand breaks in cells with the rank order of the potencies being EB>≈EBD≫BDD. All three compounds failed to cause statistically significant increases in DNA migration in pre-lysed cells, suggesting that they did not produce strand breaks through chemical pathways under our experimental conditions. By using comet assays at pH 11.9 and pH 9, it was demonstrated that EB and EBD generated both single-strand breaks (SSB) and alkali-labile sites, but BDD produced only SSB. To our knowledge, this is the first report to investigate EBD- and BDD-induced strand breaks in cells. The results implied that EBD could play an important role in toxicity of BD.

  17. Evidence-Based Design and Research-Informed Design.

    Science.gov (United States)

    Peavey, Erin; Vander Wyst, Kiley B

    2017-01-01

    This article provides critical examination and comparison of the conceptual meaning and underlying assumptions of the concepts evidence-based design (EBD) and research-informed design (RID) in order to facilitate practical use and theoretical development. In recent years, EBD has experienced broad adoption, yet it has been simultaneously critiqued for rigidity and misapplication. Many practitioners are gravitating to the term RID to describe their method of integrating knowledge into the design process. However, the term RID lacks a clear definition and the blurring of terms has the potential to weaken advances made integrating research into practice. Concept analysis methods from Walker and Avant were used to define the concepts for comparison. Conceptual definitions, process descriptions, examples (i.e., model cases), and methods of evaluation are offered for EBD and RID. Although EBD and RID share similarities in meaning, the two terms are distinct. When comparing evidence based (EB) and research informed, EB is a broad base of information types (evidence) that are narrowly applied (based), while the latter references a narrow slice of information (research) that is broadly applied (informed) to create an end product of design. Much of the confusion between the use of the concepts EBD and RID arises out of differing perspectives between the way practitioners and academics understand the underlying terms. The authors hope this article serves to generate thoughtful dialogue, which is essential to the development of a discipline, and look forward to the contribution of the readership.

  18. Comparison of device structures for the dielectric breakdown measurement of hexagonal boron nitride

    Science.gov (United States)

    Hattori, Yoshiaki; Taniguchi, Takashi; Watanabe, Kenji; Nagashio, Kosuke

    2016-12-01

    Improving the film quality in the synthesis of large-area hexagonal boron nitride films (h-BN) for two-dimensional material devices remains a great challenge. The measurement of electrical breakdown dielectric strength (EBD) is one of the most important methods to elucidate the insulating quality of h-BN. In this work, the EBD of high quality exfoliated single-crystal h-BN was investigated using three different electrode structures under different environmental conditions to determine the ideal electrode structure and environment for EBD measurement. A systematic investigation revealed that EBD is not sensitive to contact force or electrode area but strongly depends on the relative humidity during measurement. Once the measurement environment is properly managed, it was found that the EBD values are consistent within experimental error regardless of the electrode structure, which enables the evaluation of the crystallinity of synthesized h-BN at the microscopic and macroscopic level by utilizing the three different electrode structures properly for different purposes.

  19. Professionalizing midwifery: exploring medically imagined labor rooms in rural Rajasthan.

    Science.gov (United States)

    Price, Sara

    2014-12-01

    In India, globalized flows of biomedical discourse like evidence-based delivery practices (EBDs) and new technologies are reshaping the field of reproductive health care. As iterations of evidence-based medicine shift, non-governmental organizations (NGOs) increasingly act as distributive agents for biomedical projects that equate modernized health care spaces and provider-care techniques with a marked improvement in the safety of birth outcomes. In this article, I examine how particular local iterations of EBDs are distributed to skilled birth attendants (SBAs) who have become sites for globalized projects aimed at reshaping their professional designation. I draw on data collected through in-depth ethnographic interviews with SBAs practicing in health centers around southern Rajasthan to explore the dynamics and tensions surrounding the professionalization of midwives and the increasing promotion of EBDs in institutional labor rooms.

  20. On the Performance of Spectrum Sensing Algorithms using Multiple Antennas

    CERN Document Server

    Liang, Ying-Chang; Zeng, Yonghong

    2010-01-01

    In recent years, some spectrum sensing algorithms using multiple antennas, such as the eigenvalue based detection (EBD), have attracted a lot of attention. In this paper, we are interested in deriving the asymptotic distributions of the test statistics of the EBD algorithms. Two EBD algorithms using sample covariance matrices are considered: maximum eigenvalue detection (MED) and condition number detection (CND). The earlier studies usually assume that the number of antennas (K) and the number of samples (N) are both large, thus random matrix theory (RMT) can be used to derive the asymptotic distributions of the maximum and minimum eigenvalues of the sample covariance matrices. While assuming the number of antennas being large simplifies the derivations, in practice, the number of antennas equipped at a single secondary user is usually small, say 2 or 3, and once designed, this antenna number is fixed. Thus in this paper, our objective is to derive the asymptotic distributions of the eigenvalues and condition...

  1. Effect of Endoscopic Balloon Dilation Treatment on the Quality of the Life%经内镜下气囊治疗对胆总管结石患者生存质量的影响

    Institute of Scientific and Technical Information of China (English)

    麻树人; 张宁; 潘汝明; 杨琳; 常丽亚; 袁爱娇

    2001-01-01

    Objective To evaluate the effect of endoscopic balloon dilation treatment on the quality of life (QOL) in patients with common bile duct stones . Method EBD of the sphincter of Oddi and removal of the stones by balloon , basket and mechanical lithotripcy were performed in 47 patients with common bile duct stones .The QOL of the patients before and after the treatment was scaled . Result The success rate of EBD for the treatment of common bile duct stones was 91.5% (43/47) in our group . The scales of QOL in 89.3% of patients after treatment were significant higher than before (p<0.05). Conclusion EBD for the treatment of common bile duct stones are possible ,effective and safe .

  2. Sparkling extreme-ultraviolet bright dots observed with Hi-C

    Energy Technology Data Exchange (ETDEWEB)

    Régnier, S.; Alexander, C. E.; Walsh, R. W. [Jeremiah Horrocks Institute, University of Central Lancashire, Preston, Lancashire, PR1 2HE (United Kingdom); Winebarger, A. R.; Cirtain, J. [NASA Marshall Space Flight Center, VP 62, Huntsville, AL 35812 (United States); Golub, L.; Korreck, K. E.; Weber, M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Mitchell, N.; Platt, S. [School of Computing, Engineering and Physical Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE (United Kingdom); De Pontieu, B.; Title, A. [Lockheed Martin Solar and Astrophysics Laboratory, 3251 Hanover Street, Palo Alto, CA 94304 (United States); Kobayashi, K. [Center for Space Plasma and Aeronomic Research, 320 Sparkman Dr, Huntsville, AL 35805 (United States); Kuzin, S. [Lebedev Physical Institute, Russian Academy of Sciences, Leninskii pr. 53, Moscow, 119991 (Russian Federation); DeForest, C. E. [Southwest Research Institute, 1050 Walnut Street Suite 300, Boulder, CO 80302 (United States)

    2014-04-01

    Observing the Sun at high time and spatial scales is a step toward understanding the finest and fundamental scales of heating events in the solar corona. The high-resolution coronal (Hi-C) instrument has provided the highest spatial and temporal resolution images of the solar corona in the EUV wavelength range to date. Hi-C observed an active region on 2012 July 11 that exhibits several interesting features in the EUV line at 193 Å. One of them is the existence of short, small brightenings 'sparkling' at the edge of the active region; we call these EUV bright dots (EBDs). Individual EBDs have a characteristic duration of 25 s with a characteristic length of 680 km. These brightenings are not fully resolved by the SDO/AIA instrument at the same wavelength; however, they can be identified with respect to the Hi-C location of the EBDs. In addition, EBDs are seen in other chromospheric/coronal channels of SDO/AIA, which suggests a temperature between 0.5 and 1.5 MK. Based on their frequency in the Hi-C time series, we define four different categories of EBDs: single peak, double peak, long duration, and bursty. Based on a potential field extrapolation from an SDO/HMI magnetogram, the EBDs appear at the footpoints of large-scale, trans-equatorial coronal loops. The Hi-C observations provide the first evidence of small-scale EUV heating events at the base of these coronal loops, which have a free magnetic energy of the order of 10{sup 26} erg.

  3. Language and reading comprehension in middle childhood predicts emotional and behaviour difficulties in adolescence for those with permanent childhood hearing loss.

    Science.gov (United States)

    Stevenson, Jim; Pimperton, Hannah; Kreppner, Jana; Worsfold, Sarah; Terlektsi, Emmanouela; Mahon, Merle; Kennedy, Colin

    2017-09-05

    Permanent childhood hearing loss (PCHL) is associated with an elevated level of emotional and behaviour difficulties (EBD). In children and adolescents with PCHL, EBD has been found to be linked to language ability in children with PCHL. The present study was designed to test whether childhood language and/or reading comprehension abilities of children with PCHL predict subsequent EBD in adolescence. Language comprehension (LC) and reading comprehension (RC) were measured at ages 6-10 years (Time 1) and 13-20 years (Time 2) in participants with PCHL who preferred to communicate using spoken language (n = 57) and a hearing comparison group (n = 38). EBD was measured at both time points by parent and by teacher ratings on the Strengths and Difficulties Questionnaire. Within the PCHL group there were negative correlations between EBD scores and concurrent LC and RC scores at Time 1 and at Time 2. Cross-lagged latent variable models fitted to the longitudinal data indicated that the associations between LC, RC and teacher-rated EBD were more likely to arise from the impact of LC and RC on behaviour rather than the other way around. In those with PCHL, poor language and reading comprehension in middle childhood increased the risk of emotional and behaviour difficulties at school in the teenage years. The results suggest that effective language and literacy interventions for children with hearing loss may also bring benefits to their mental health. © 2017 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

  4. Special Education Teacher Preparation in Classroom Management: Implications for Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Oliver, Regina M.; Reschly, Daniel J.

    2010-01-01

    Special education teachers' skills with classroom organization and behavior management affect the emergence and persistence of behavior problems as well as the success of inclusive practice for students with emotional and behavioral disorders (EBD). Adequate special education teacher preparation and strong classroom organization and behavior…

  5. Psychometric properties of the Arabic self-report version of the strengths and difficulties questionnaire.

    Science.gov (United States)

    Emam, Mahmoud Mohamed; Abu Hilal, Maher M; Kazem, Ali Mahdi; Alkharousi, Suad Juma

    2016-12-01

    Students in middle school tend to display emotional and behavioural difficulties (EBDs) compared to other forms of psychopathology. Early identification of EBDs is therefore a priority in order to prevent the chronic co-morbidity with other forms of psychopathology which may affect students' academic achievement. Assessment of EBDs has been traditionally undertaken via proxy reporting; but psychometrically rigorous instruments are needed so that children and adolescents can report on their own emotions and behaviours. Such need increases in the Omani context given the lack of EBDs adequate assessment instruments. In the current study the factor structure of the Arabic self-report version of the Strengths and Difficulties Questionnaire (A-SDQ) was examined in a sample of 815 middle school students (mean age=14 years). The study tested the SDQ original five-factor model which received considerable empirical support. Responses on the A-SDQ were compared to responses obtained via proxy reports from teachers and parents through confirmatory factor analyses (CFAs). Results showed a reasonable fit for the three informant forms. Nevertheless, there were differences in item loadings across the three informant forms. Additionally, participants' self-report responses were tested for invariance across gender. CFAs provided support to the invariance hypothesis for item loadings, indicating that the items were similarly valid indices of the five factors for males and females. Factor correlations, factor variances and item residuals were not invariant across gender.

  6. Class-Wide Function-Related Intervention Teams: Effects of Group Contingency Programs in Urban Classrooms

    Science.gov (United States)

    Kamps, Debra; Wills, Howard P.; Heitzman-Powell, Linda; Laylin, Jeff; Szoke, Carolyn; Petrillo, Tai; Culey, Amy

    2011-01-01

    The purpose of the study was to determine the effectiveness of the Class-Wide Function-related Intervention Teams (CW-FIT) program, a group contingency intervention for whole classes, and for students with disruptive behaviors who are at risk for emotional/behavioral disorders (EBD). The CW-FIT program includes four elements designed from…

  7. An Analysis of Job Satisfaction for Special Educators Who Instruct Students with Emotional/Behavioral Disorders: How Working Conditions Impact Commitment

    Science.gov (United States)

    Adkins, Beverly

    2009-01-01

    Teachers of students with emotional/behavioral disorders (E/BD) find that myriad concerns for effective teaching (e.g., salaries, increased paperwork, classroom management) challenge their ability to meet personal and professional needs. The push for certified teachers and limited training to work with students with special needs create stressors…

  8. Update on endoscopic management of gastric outlet obstruction in children

    Science.gov (United States)

    Chao, Hsun-Chin

    2016-01-01

    Endoscopic balloon dilatation (EBD) and surgical intervention are two most common and effective treatments for gastric outlet obstruction. Correction of gastric outlet obstruction without the need for surgery is an issue that has been tried to be resolved in these decades; this management has developed with EBD, advanced treatments like local steroid injection, electrocauterization, and stent have been added recently. The most common causes of pediatric gastric outlet obstruction are idiopathic hypertrophic pyloric stenosis, peptic ulcer disease followed by the ingestion of caustic substances, stenosis secondary to surgical anastomosis; antral web, duplication cyst, ectopic pancreas, and other rare conditions. A complete clinical, radiological and endoscopic evaluation of the patient is required to make the diagnosis, with complimentary histopathologic studies. EBD are used in exceptional cases, some with advantages over surgical intervention depending on each patient in particular and on the characteristics and etiology of the gastric outlet obstruction. Local steroid injection and electrocauterization can augment the effect of EBD. The future of endoscopic treatment seems to be aimed at the use of endoscopic electrocauterization and balloon dilatations.

  9. The Social, Emotional and Behavioural Difficulties of Primary School Children with Poor Attendance Records

    Science.gov (United States)

    Carroll, H. C. M.

    2013-01-01

    Two complementary studies of poor and better attenders are presented. To measure emotional and behavioural difficulties (EBD) different teacher-completed rating scales were employed, and to determine social difficulties, the studies used sociometry and some items from the scales. One study had a longitudinal design. It revealed that, after…

  10. What Are They Thinking? The Moral Judgment of Children with Emotional and Behavioral Disorders

    Science.gov (United States)

    Hardman, Elizabeth L.

    2015-01-01

    This study was conducted to describe the moral judgment of 12 third- through fifth-grade children with and without emotional and behavioral disorders (EBD) and to explore how feelings affected their thought processes. Data were gathered via three individually conducted moral dilemma interviews with each child participant. These procedures produced…

  11. The Effects of a Dog Reading Visitation Program on Academic Engagement Behavior in Three Elementary Students with Emotional and Behavioral Disabilities: A Single Case Design

    Science.gov (United States)

    Bassette, Laura A.; Taber-Doughty, Teresa

    2013-01-01

    Background: Children with emotional and behavioral disabilities (EBD) struggle with behavioral problems during reading activities in school. One way to address these concerns may be through dog reading programs which are increasing in popularity in schools and libraries. Preliminary anecdotal research suggests dog reading programs may improve…

  12. The Effects of Strategy Instruction for Writing and Revising Persuasive Quick Writes on Middle School Students with Emotional Behavioral Disorders

    Science.gov (United States)

    Cramer, Maryanne Mong

    2011-01-01

    A multiple baseline alternating treatment (A-B-C-D) design was used to evaluate the effectiveness of strategies for teaching persuasive writing and peer revision. Eight middle school students enrolled in an alternative program for students with emotional and behavioral disorders (EBD) received Self-Regulated Strategy Development (SRSD) instruction…

  13. Teaching Paragraph Composition to Students with Emotional/Behavioral Disorders Using the Simultaneous Prompting Procedure

    Science.gov (United States)

    Hudson, Tina Marlene; Hinkson-Lee, Kim; Collins, Belva

    2013-01-01

    The purpose of this study was to examine the effectiveness of the simultaneous prompting procedure in teaching paragraph composition to 4, 5th grade students identified with emotional behavioral disorder (EBD) and attention-deficit hyperactivity disorder (ADHD). The instructor taught students how to construct and proofread a 5-sentence paragraph…

  14. A Brief Social Skills Intervention to Reduce Challenging Classroom Behavior

    Science.gov (United States)

    McDaniel, Sara C.; Bruhn, Allison L.; Troughton, Leonard

    2017-01-01

    Social skills instruction has been recommended as a way of improving behavioral and social outcomes for students with emotional and behavioral disorders (EBD). A brief social skills intervention ("Stop and Think" (Knoff in "The stop & think social skills program," Sopris West, Longmont, CO, 2001) was used to extend the…

  15. Social Validation of Services for Youth with Emotional and Behavioral Disorders: A Comparative Study

    Science.gov (United States)

    Beaudoin, Kathleen M.; Knuth, Richard; Benner, Gregory J.

    2008-01-01

    This study investigated the perceptions of 302 building administrators regarding their building level programs serving students with emotional and behavioral disorders (EBD). Comparisons were made between administrators of schools that housed self-contained programs and administrators from schools without self-contained programs on factors…

  16. Sparkling EUV bright dots observed with Hi-C

    CERN Document Server

    Regnier, S; Walsh, R W; Winebarger, A R; Cirtain, J; Golub, L; Korreck, K E; Mitchell, N; Platt, S; Weber, M; De Pontieu, B; Title, A; Kobayashi, K; Kuzin, S; DeForest, C E

    2014-01-01

    Observing the Sun at high time and spatial scales is a step towards understanding the finest and fundamental scales of heating events in the solar corona. The Hi-C instrument has provided the highest spatial and temporal resolution images of the solar corona in the EUV wavelength range to date. Hi-C observed an active region on 11 July 2012, which exhibits several interesting features in the EUV line at 193\\AA: one of them is the existence of short, small brightenings ``sparkling" at the edge of the active region; we call these EUV Bright Dots (EBDs). Individual EBDs have a characteristic duration of 25s with a characteristic length of 680 km. These brightenings are not fully resolved by the SDO/AIA instrument at the same wavelength, however, they can be identified with respect to the Hi-C location of the EBDs. In addition, EBDs are seen in other chromospheric/coronal channels of SDO/AIA suggesting a temperature between 0.5 and 1.5 MK. Based on their frequency in the Hi-C time series, we define four different...

  17. The Effects of Positive Verbal Reinforcement on the Time Spent outside the Classroom for Students with Emotional and Behavioral Disorders in a Residential Setting

    Science.gov (United States)

    Kennedy, Christina; Jolivette, Kristine

    2008-01-01

    To more effectively instruct the entire class, teachers of students with emotional behavioral disorders (EBD) often choose to send students who display inappropriate behavior out of the room. A multiple baseline across settings was used to evaluate the effects of increasing teacher positive verbal reinforcement on the amount of time 2 students…

  18. What Are They Thinking? The Moral Judgment of Children with Emotional and Behavioral Disorders

    Science.gov (United States)

    Hardman, Elizabeth L.

    2015-01-01

    This study was conducted to describe the moral judgment of 12 third- through fifth-grade children with and without emotional and behavioral disorders (EBD) and to explore how feelings affected their thought processes. Data were gathered via three individually conducted moral dilemma interviews with each child participant. These procedures produced…

  19. Mindfulness for Students Classified with Emotional/Behavioral Disorder

    Science.gov (United States)

    Malow, Micheline S.; Austin, Vance L.

    2016-01-01

    A six-week investigation utilizing a standard mindfulness for adolescents curriculum and norm-based standardized resiliency scale was implemented in a self-contained school for students with Emotional/Behavioral Disorders (E/BD). Informal integration of mindfulness activities into a classroom setting was examined for ecological appropriateness and…

  20. Cartografía de especies de matorral de la reserva biológica de Doñana mediante el sistema hiperespectral aeroportado INTA-AHS. Implicaciones en el estudio y seguimiento del matorral de Doñana

    OpenAIRE

    Jiménez Michavila, Marcos

    2011-01-01

    Resumen de Tesis Doctoral, Área de Teledetección del INTA. Departamento de Ecología de la Universidad Autónoma de Madrid, Fecha: Julio 2011, Dirección: Antonio Pou (UAM), Ricardo Díaz-Delgado (EBD-CSIC).

  1. Social Skills Training in Natural Play Settings: Educating through the Physical Theory to Practice

    Science.gov (United States)

    Aljadeff-Abergel, Elian; Ayvazo, Shiri; Eldar, Eitan

    2012-01-01

    Social skills are prerequisite to academic performance and success in school. Training of these skills is particularly important for students with emotional and behavioral disorders (EBD) who have social deficits and struggle maintaining appropriate and accepted behavior in and outside of the classroom. Educating through the "physical" model is a…

  2. Phase distribution of products of radiation and post-radiation distillation of biopolymers: Cellulose, lignin and chitin

    Energy Technology Data Exchange (ETDEWEB)

    Ponomarev, A.V., E-mail: ponomarev@ipc.rssi.ru [A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninsky Prospect 31, 119991 Moscow (Russian Federation); Kholodkova, E.M.; Metreveli, A.K.; Metreveli, P.K.; Erasov, V.S.; Bludenko, A.V.; Chulkov, V.N. [A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninsky Prospect 31, 119991 Moscow (Russian Federation)

    2011-11-15

    Influence of both the absorbed dose and the dose rate of 8 MeV electron-beam radiation on destruction of microcrystalline cellulose, pine lignin and krill chitin was investigated. Two conversion modes were compared: (1) post-radiation distillation PRD and (2) electron-beam distillation EBD. Cellulose, chitin and lignin demonstrate different responses to irradiation and distillation in PRD and EBD modes. Treatment in EBD mode transforms biopolymers to organic liquid more productively than conventional dry distillation and treatment in PRD mode. Both radiation heating and an irradiation without heating intensify chitin and cellulose decomposition and distillation. At the same time lignin decaying rather efficiently in EBD mode appears to be insensitive to a preliminary irradiation in PRD mode up to a dose of 2.4 MGy. - Highlights: > Direct conversion of cellulose, chitin and lignin to organic liquid is intensified by electron-beam irradiation. > Alternative approach to bio-oil production. > Both electron-beam distillation mode and post-radiation distillation mode are effective for cellulose and chitin conversion. > Electron-beam distillation mode is preferable for lignin conversion. > Preliminary deep dehydration of biopolymers is realizable at low dose rates.

  3. Knowledge of evidence-based dentistry among academic dental practitioners of Bhopal, India: a preliminary survey

    Directory of Open Access Journals (Sweden)

    Aishwarya Singh

    2015-06-01

    Full Text Available This study aimed to characterize the knowledge of evidence-based dentistry (EBD among dental faculty members in the city of Bhopal in central India. A cross-sectional questionnaire was administered at two dental colleges in Bhopal City. All dental faculty members who were present on the day of the study and who agreed to participate were included in the study. A total of 50 dental faculty members returned the questionnaire. Six Likert-type questions were asked, and the percentages of various responses were used for analysis. Sixteen faculty members (32.0% strongly agreed that EBD is a process of making decisions based on scientifically proven evidence. Fifteen faculty members (30.0% strongly disagreed or disagreed with the item stating that the best and quickest way to find evidence is by reading textbooks or asking experienced colleagues. Thirteen faculty members (26.0% strongly agreed that EBD allows dentists to improve their scientific knowledge and clinical skills. It is recommended that EBD be included in undergraduate and postgraduate curricula and in intensive continuing dental education programs that are conducted for dental faculty members.

  4. Children with emotional and behavioral disorders in special education : Placement, progress, and family functioning

    NARCIS (Netherlands)

    Stoutjesdijk, Regina

    2014-01-01

    The studies described in this dissertation focus on children with emotional and behavioral disorders (EBD) in special education. It was found that poor academic performance, relational problems between children and caregivers, and the age at which youth care was involved for the first time predicted

  5. The Effects of Function-Based Self-Management Interventions on Student Behavior

    Science.gov (United States)

    Hansen, Blake D.; Wills, Howard P.; Kamps, Debra M.; Greenwood, Charles R.

    2014-01-01

    Children with emotional and behavioral disorders (E/BD) struggle to achieve social and academic outcomes. Many studies have demonstrated self-management interventions to be effective at reducing problem behavior and increasing positive social and academic behaviors. Functional behavior assessment (FBA) information may be used in designing…

  6. Social Skills Training and Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Casey, Kathryn J.

    2012-01-01

    There is a large body of literature suggesting that students with emotional and behavioral disorders (EBD) lack appropriate social skills, including deficits in building and maintaining interpersonal relationships, prosocial behaviors (e.g., sharing, helping, cooperation), and self-management strategies. While the literature shows small to modest…

  7. The innervation of rainbow trout (Oncorhynchus mykiss) liver: protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities.

    Science.gov (United States)

    Esteban, F J; Jiménez, A; Barroso, J B; Pedrosa, J A; del Moral, M L; Rodrigo, J; Peinado, M A

    1998-08-01

    We have explored the innervation of the rainbow trout (O. mykiss) liver using immunohistochemical procedures and light microscopy to detect in situ protein gene product 9.5 and neuronal nitric oxide synthase immunoreactivities (PGP-IR and NOS-IR). The results showed PGP-IR nerve fibres running with the extralobular biliary duct (EBD), hepatic artery (EHA) and portal vein (EPV) that form the hepatic hilum, as well as following the spatial distribution of the intrahepatic blood vessel and biliary channels. These nerve fibres appear as single varicose processes, thin bundles, or thick bundles depending on their diameter and location in the wall of the blood vessel or biliary duct. No PGP-IR fibres were detected in the liver parenchyma. NOS-IR nerve fibres were located only in the vessels and ducts that form the hepatic hilum (EBD, EHA, EPV); in addition, NOS-IR nerve cell bodies were found isolated or forming ganglionated plexuses in the peribiliary fibromuscular tissue of the EBD. No PGP-IR ganglionated plexuses were detected in the EBD. The location of the general (PGP-IR) and nitrergic (nNOS-IR) intrinsic nerves of the trout liver suggest a conserved evolutionary role of the nervous control of hepatic blood flow and hepatobiliary activity.

  8. Disproportionality of English Learners with Emotional and/or Behavioral Disorders: A Comparative Meta-Analysis with English Learners with Learning Disabilities

    Science.gov (United States)

    Gage, Nicholas; Gersten, Russell; Sugai, George; Newman-Gonchar, Rebecca

    2013-01-01

    Disproportionate representation of English learners in special education has been a longstanding and ongoing concern. However, research examining disproportionate representation of English learners receiving special education services for emotional and/or behavioral disorders (EBD) has been limited. To address this gap, a meta-analysis of…

  9. Social Skills Instruction for Urban Learners with Emotional and Behavioral Disorders: A Culturally Responsive and Computer-Based Intervention

    Science.gov (United States)

    Robinson-Ervin, Porsha; Cartledge, Gwendolyn; Musti-Rao, Shobana; Gibson, Lenwood, Jr.; Keyes, Starr E.

    2016-01-01

    This study examined the effects of culturally relevant/responsive, computer-based social skills instruction on the social skill acquisition and generalization of 6 urban African American sixth graders with emotional and behavioral disorders (EBD). A multiple-probe across participants design was used to evaluate the effects of the social skills…

  10. Stakeholders' Voices: Defining Needs of Students with Emotional and Behavioral Disorders Transitioning between School Settings

    Science.gov (United States)

    Buchanan, Rohanna; Nese, Rhonda N. T.; Clark, Miriam

    2016-01-01

    Students with emotional and behavioral disorders (EBD) too often do not receive adequate services or care in their school settings, particularly during transitions in educational placements. In addition, school support teams often struggle with creating transition plans that honor the needs of students with input from key stakeholders responsible…

  11. Intertextuelle und intramediale Bezüge als Orientierungsangebot – systematische Überlegungen und exemplarische Untersuchungen zu Verweisen auf das Fernsehangebot

    Directory of Open Access Journals (Sweden)

    Ben Bachmair

    2017-07-01

    Full Text Available Auch wenn das Internet sich weder so schnell noch so nachhaltig im Alltag und als Bestandteil von Massenkommunikation etablierte, wie es Ende der neunziger Jahre den Anschein hatte, so zeigt sich am Internet doch, was sich mit der Vernetzungs- und Verfügbarkeitslogik verändern könnte, die dem Internet zu eigen ist. Manuel Castells (2001 mit seiner Analyse des „Informationszeitalters“ und der als instrumentellem Netzwerk organisierten Gesellschaft skizziert die Umrisse, wie sich unsere Gesellschaft mit welcher Dynamik entwickelt. Er spricht von einer „informationeilen Entwicklungsweise“ (ebd., S. 17, die anders als die „agrarische“ oder die „industrielle“ auf das gesellschaftliche Verhältnis der Menschen zur Natur („Produktion“, zu sich selber („Erfahrung“, „kulturelle Identität“ und zu anderen (.Macht“ einwirkt. Einen Aspekt dieser „informationellen Entwicklungsweise“ beschreibt Castells mit dem Hinweis auf „globale Netzwerke der Instrumentalität“, die eine „unüberschaubare Anzahl virtueller Gemeinschaften“ hervorbringt (ebd., S. 23. Dabei konstituiert sich auch eine Art von Subjektivität, die sich im Moment als „zunehmende Distanz zwischen Globalisierung und Identität, zwischen dem Netz und dem Ich“ beschreiben lässt (ebd., S. 24. In dieser Spannung bekommt .Multimedia“ die Funktion einer „symbolischen Umwelt“ (ebd., S. 415.

  12. Functional Behavioral Assessment-Based Interventions for Students with or at Risk for Emotional and/or Behavioral Disorders in School: A Hierarchical Linear Modeling Meta-Analysis

    Science.gov (United States)

    Gage, Nicholas A.; Lewis, Timothy J.; Stichter, Janine P.

    2012-01-01

    Of the myriad practices currently utilized for students with disabilities, particularly students with or at risk for emotional and/or behavioral disorder (EBD), functional behavior assessment (FBA) is a practice with an emerging solid research base. However, the FBA research base relies on single-subject design (SSD) and synthesis has relied on…

  13. Individual and Systemic Approaches to Collaboration and Consultation on Behalf of Students with Emotional/Behavioral Disorders. From the Second CCBD Mini Library Series: Successful Interventions for the 21st Century.

    Science.gov (United States)

    Gable, Robert A.; Sugai, George; Lewis, Tim; Nelson, J. Ron; Cheney, Douglas; Safran, Stephen P.; Safran, Joan S.

    This monograph discusses using collaboration and consultation to teach children and youth with emotional and behavioral disorders (EBD) in the general education classroom. After an introductory chapter, Chapter 2, "Collaboration and Consultation: Promises and Limitations," compares collaboration and consultation as they relate to serving…

  14. Knowledge of evidence-based dentistry among academic dental practitioners of Bhopal, India: a preliminary survey.

    Science.gov (United States)

    Singh, Aishwarya; Saxena, Sudhanshu; Tiwari, Vidhatri; Tiwari, Utkarsh

    2015-01-01

    This study aimed to characterize the knowledge of evidence-based dentistry (EBD) among dental faculty members in the city of Bhopal in central India. A cross-sectional questionnaire was administered at two dental colleges in Bhopal City. All dental faculty members who were present on the day of the study and who agreed to participate were included in the study. A total of 50 dental faculty members returned the questionnaire. Six Likert-type questions were asked, and the percentages of various responses were used for analysis. Sixteen faculty members (32.0%) strongly agreed that EBD is a process of making decisions based on scientifically proven evidence. Fifteen faculty members (30.0%) strongly disagreed or disagreed with the item stating that the best and quickest way to find evidence is by reading textbooks or asking experienced colleagues. Thirteen faculty members (26.0%) strongly agreed that EBD allows dentists to improve their scientific knowledge and clinical skills. It is recommended that EBD be included in undergraduate and postgraduate curricula and in intensive continuing dental education programs that are conducted for dental faculty members.

  15. Endoscopic biliary drainage for patients with unresectable pancreatic cancer with obstructive jaundice who are to undergo gemcitabine chemotherapy

    Institute of Scientific and Technical Information of China (English)

    Osamu Takasawa; Naotaka Fujita; Go Kobayashi; Yutaka Noda; Kei Ito; Jun Horaguchi

    2006-01-01

    AIM: To assess optimum endoscopic biliary drainage (EBD) in cases with unresectable pancreatic cancer in the era of gemcitabine (GEM).METHODS: Thirty patients with unresectable pancreatic cancer, who presented with jaundice and underwent chemotherapy using GEM after EBD were included in this study (GEM group). Fifteen cases with the same clinical manifestation and stage of pancreatic cancer treated with EBD alone were also included as controls. A covered metallic stent (CMS) or a plastic stent (PS) was used for EBD. The mean survival time (MST) in each group,risk factors of survival time, type of stent used and associated survival time, occlusion rate of stent, patency period of stent, and risk factors of stent occlusion were evaluated.RESULTS: MST in the GEM group was longer than that in the control (9.9 mo vs 6.2 mo). In the GEM group,the survival time was not different between those who underwent metallic stenting and those who underwent plastic stenting. Stent occlusion occurred in 60% of the PS group and 7% of the CMS group. The median stent patency in the PS-GEM group and the CMS-GEM group was 5 mo and 7.5 mo, respectively. Use of a PS was the only risk factor of stent occlusion.CONCLUSION: A CMS is recommended in cases presenting with jaundice due to unresectable pancreatic cancer, since the use of a CMS makes it possible to continue chemotherapy using GEM without repetition of stent replacement.

  16. Cross-Setting Correspondence in Sociometric Nominations among Children with Attention-Deficit/Hyperactivity Disorder

    Science.gov (United States)

    Mikami, Amori Yee; Hoza, Betsy; Hinshaw, Stephen P.; Arnold, L. Eugene; Hechtman, Lily; Pelham, William E., Jr.

    2015-01-01

    Peer problems are common among children with emotional and behavioral disorders (EBD). However, the extent to which children's peer functioning varies across settings is unknown, as is the incremental power of peer functioning in different settings in predicting subsequent psychopathology. Participants were 57 children with…

  17. Psychometric properties of a shortened version of the Physical Self-Concept Questionnaire (PSQ-S).

    Science.gov (United States)

    Rodríguez-Fernández, Arantzazu; Axpe, Inge; Goñi, Alfredo

    2015-01-01

    The four-dimensional model of physical self-concept which differentiates the physical self-perceptions of ability, condition, attractiveness and strength is widely accepted. In the last two decades much research has been done on the physical self-concept and its relations with the psychological well-being/distress, anxiety disorders or Eating Behavior Disorders (EBD). To validate a shortened version of the Physical Self-Concept Questionnaire (PSQ-S) and verify its ability to discriminate between people with different levels of EBD. Responses of 1478 subjects between 13 and 21 years old to the shortened version of the PSQ were analyzed in order to check indexes of reliability and validity. Furthermore, the scores of 96 women aged 14 to 23 years old diagnosed of EBD were compared to 96 others without clinical diagnosis. The results indicate a reliability of 0.93 and confirm the tetrafactorial structure of the physical selfconcept. The highest physical self-concept is that of those without a clinical diagnosis of EBD. The Shortened-PSQ is a simple, reliable and suitable screening tool both for educational and clinical settings. It also provides a sufficient measure of physical self-concept for research purposes.

  18. Reflections on the Future of Council for Children with Behavioral Disorders: A Response to Colvin, Forness, and Nelson

    Science.gov (United States)

    Peck, Alec F.; Albrecht, Susan Fread; George, Cheryl L.; Mathur, Sarup R.; Paget, Mike; Ryan, Joseph B.; White, Richard B.; Baker, Diana

    2012-01-01

    In issue 37(1) of this journal, the authors published the findings of three studies addressing the status of Council for Children with Behavioral Disorders (CCBD) as an organization and of the field of special education for students with emotional and behavioral disorders (E/BD). In order to continue discussion of the status of CCBD, the editors…

  19. C-CARD: A Strategy to Improve Revising Behaviors

    Science.gov (United States)

    Saddler, Bruce; Asaro-Saddler, Kristie; Thomas, Job

    2015-01-01

    Students with emotional and behavioral disorders (EBD) often perform well below their peers across academic areas, with lower math and reading scores and higher school failure and grade retention rates (Reid, Gonzalez, Nordness, Trout, & Epstein, 2004). However, writing is the most significant academic deficit for these students (Austinner,…

  20. Using Comparison Peers as an Objective Measure of Social Validity: Recommendations for Researchers

    Science.gov (United States)

    Ennis, Robin Parks; Jolivette, Kristine; Fredrick, Laura D.; Alberto, Paul A.

    2013-01-01

    In this article, students with challenging behaviors (SWCB) in a classroom may include those with attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), emotional and behavioral disorders (E/BD), intellectual disabilities, learning disabilities, and those at risk of these disabilities. These students may present…

  1. Function-Based Planning for Young Children at Risk for Emotional and Behavioral Disorders

    Science.gov (United States)

    Nahgahgwon, Kari N.; Umbreit, John; Liaupsin, Carl J.; Turton, Amina M.

    2010-01-01

    This study examined the efficacy of function-based intervention for young children at-risk for emotional and behavioral disorders (EBD) in inclusive environments. Participants were two kindergarten students and one first-grade student, all of whom exhibited chronic disruptive behavior in the classroom despite previous interventions implemented…

  2. Classroom-Based Functional Analysis and Intervention for Students with Emotional/Behavioral Disorders

    Science.gov (United States)

    Wright-Gallo, Glenna L.; Higbee, Thomas S.; Reagon, Kara A.; Davey, Bryan J.

    2006-01-01

    We conducted functional analyses of disruptive behavior in a classroom setting for two students of typical intelligence with emotional/behavioral disorders (E/BD) using the classroom teacher to implement functional analysis conditions. The functional analyses suggested that both participants' disruptive behavior was maintained by escape from task…

  3. Review of Video Modeling with Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Baker, Sonia D.; Lang, Russell; O'Reilly, Mark

    2009-01-01

    Students with emotional and behavioral disorders (EBD) often engage in behavior that is disruptive in the classroom, impedes educational progress, and inhibits peer relationships. Video modeling has been demonstrated to be an effective intervention for other challenging populations (e.g., autism) and has been identified as a feasible intervention…

  4. Review of Video Modeling with Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Baker, Sonia D.; Lang, Russell; O'Reilly, Mark

    2009-01-01

    Students with emotional and behavioral disorders (EBD) often engage in behavior that is disruptive in the classroom, impedes educational progress, and inhibits peer relationships. Video modeling has been demonstrated to be an effective intervention for other challenging populations (e.g., autism) and has been identified as a feasible intervention…

  5. Behavior Modification/Traditional Techniques for Students with Emotional and Behavioral Disorders

    Science.gov (United States)

    Mooney, Paul; Ryan, Joseph B.; Gunter, Philip L.; Denny, R. Kenton

    2012-01-01

    In addressing positive general education teaching practices for use with students with or at risk for emotional and behavioral disorders (EBD), the chapter emphasizes teacher behavior change research that has been informed by applied behavior analytic (ABA) principles. Its central theme is that general education teachers can access research…

  6. BEST in CLASS: A Classroom-Based Model for Ameliorating Problem Behavior in Early Childhood Settings

    Science.gov (United States)

    Vo, Abigail; Sutherland, Kevin S.; Conroy, Maureen A.

    2012-01-01

    As more young children enter school settings to attend early childhood programs, early childhood teachers and school psychologists have been charged with supporting a growing number of young children with chronic problem behaviors that put them at risk for the development of emotional/behavioral disorders (EBDs). There is a need for effective,…

  7. Changing Attitudes: Supporting Teachers in Effectively Including Students with Emotional and Behavioural Difficulties in Mainstream Education

    Science.gov (United States)

    Scanlon, Geraldine; Barnes-Holmes, Yvonne

    2013-01-01

    Pupils with emotional and behavioural difficulties (EBD) are often considered the most challenging group to manage within mainstream education. The challenges perceived by teachers may be due, in part, to negative attitudes towards this cohort of pupils, which may exacerbate feelings of inadequacy and impact negatively upon direct interactions…

  8. Working Conditions as Risk or Resiliency Factors for Teachers of Students with Emotional and Behavioral Disabilities

    Science.gov (United States)

    Albrecht, Susan Fread; Johns, Beverley H.; Mounsteven, Joyce; Olorunda, Olufunmilola

    2009-01-01

    This pilot study examined working conditions reported by special education teachers of students with emotional and behavioral disorders (EBD) to identify factors common to teachers likely to leave their positions within the next 2 years and factors common to those likely to stay. Survey responses from an international sample of 776 teachers and…

  9. Social Skills Training in Natural Play Settings: Educating through the Physical Theory to Practice

    Science.gov (United States)

    Aljadeff-Abergel, Elian; Ayvazo, Shiri; Eldar, Eitan

    2012-01-01

    Social skills are prerequisite to academic performance and success in school. Training of these skills is particularly important for students with emotional and behavioral disorders (EBD) who have social deficits and struggle maintaining appropriate and accepted behavior in and outside of the classroom. Educating through the "physical" model is a…

  10. Scaffolding dynamics and the emergence of problematic learning trajectories

    NARCIS (Netherlands)

    Steenbeek, Henderien; Jansen, Louise; van Geert, Paul

    2012-01-01

    This study aims at examining problematic learning trajectories of students with emotional behavioral disorders (EBD) by means of a longitudinal and time serial (micro genetic) study of individual instruction sessions during arithmetic lessons. Micro genetic analysis techniques were applied on the va

  11. Teacher-Mediated Instructional Strategies for Students with Emotional or Behavioral Disorders

    Science.gov (United States)

    Hirn, Regina Gilkey; Park, Kristy L.

    2012-01-01

    Students with emotional and behavioral disorders (E/BD) may exhibit both learning and behavioral needs that affect the teacher's ability to provide effective instruction. Extending beyond simple academic content knowledge, effective teacher-based interventions include preventive and predictive actions that manage the disruptive behaviors often…

  12. The Effects of Function-Based Self-Management Interventions on Student Behavior

    Science.gov (United States)

    Hansen, Blake D.; Wills, Howard P.; Kamps, Debra M.; Greenwood, Charles R.

    2014-01-01

    Children with emotional and behavioral disorders (E/BD) struggle to achieve social and academic outcomes. Many studies have demonstrated self-management interventions to be effective at reducing problem behavior and increasing positive social and academic behaviors. Functional behavior assessment (FBA) information may be used in designing…

  13. Capacity and Opportunity: Predicting Engagement for Middle School Students with Behavioral Disorders

    Science.gov (United States)

    Herron, Marsha Dempsey; Martin, Jim

    2015-01-01

    This study examined the capacity and opportunity scores of 36 middle school students with emotional and behavioral disorders (EBD) on the student version of the "American Institutes for Research (AIR) Self-Determination Scale" across three school engagement factors: grade point averages (GPA), school absences, and frequency of school…

  14. The Influence of Schooling on the Aspirations of Young People with Special Educational Needs

    Science.gov (United States)

    Casey, Lorraine; Davies, Peter; Kalambouka, Afroditi; Nelson, Nick; Boyle, Bill

    2006-01-01

    The authors investigate the effect of schooling on the aspirations of young people designated as having mild learning difficulties (MLD) or emotional and behavioural difficulties (EBD) in the first large-scale study of its kind in England. Data were collected from parents and their 15/16 year-old children in the final year of their compulsory…

  15. Direct Observation of Teacher and Student Behavior in School Settings: Trends, Issues and Future Directions

    Science.gov (United States)

    Lewis, Timothy J.; Scott, Terrance M.; Wehby, Joseph H.; Wills, Howard P.

    2014-01-01

    Across the modern history of the field of special education and emotional/behavioral disorders (EBD), direct observation of student and educator behavior has been an essential component of the diagnostic process, student progress monitoring, and establishing functional and statistical relationships within research. This article provides an…

  16. Reading Instruction for Youth with Emotional and Behavioral Disorders in a Juvenile Correctional Facility

    Science.gov (United States)

    Allen-DeBoer, Robyn A.; Malmgren, Kimber W.; Glass, Mary-Elizabeth

    2006-01-01

    This study examined the effects of a systematic, phonics-based reading intervention on the oral reading fluency and accuracy of adolescents with emotional and behavioral disorders (EBD) receiving educational services in a juvenile correctional facility. A multiple-baseline design across four participants was used to calculate the effect of daily,…

  17. Educating Juveniles with Disabilities in Correctional Settings. Fifth CCBD Mini-Library Series: Meeting the Diverse Needs of Children and Youth with E/BD--Evidence-Based Programs and Practices.

    Science.gov (United States)

    Gagnon, Joseph Calvin; Mayer, Matthew J.

    This monograph addresses issues in the appropriate education of children and youth with disabilities, especially emotional and/or behavioral disorders, who are in juvenile correctional facilities. An introductory chapter considers the characteristics of students with E/BD in the public schools; educational services in juvenile corrections; and…

  18. Special Education Teachers' Perceptions of Students with Emotional Impairments and Their Same-Sex Behaviors: A Multiple Case Study

    Science.gov (United States)

    Arrieta, Stefanie A.; Palladino, John M.

    2014-01-01

    Although recent trends in educational research have addressed the educational plight of LGBT [lesbian, gay, bi-sexual, transgender, and queer/questioning] students, a dearth of literature exists about the subpopulation of LGBT youth with disabilities, namely those with verified emotional-behavior disorders (EBDs). Discussions throughout what…

  19. Effects of Oral Reading Fluency on Students with Emotional and Behavioral Disorders' Latency to Continue Reading

    Science.gov (United States)

    Vostal, Brooks R.; Lee, David L.

    2015-01-01

    Adolescents with Emotional and Behavioral Disorders (EBD) present deficits in literacy skills, in part because their disruptive behaviors interfere with task engagement. Antecedent manipulations, such as those based on behavioral momentum theory, can increase students' contact with reinforcement, leading to greater task engagement. This study…

  20. Role Models, Approaches to Studying, and Self-Efficacy in Forensic and Mainstream High School Students: A Pilot Study

    Science.gov (United States)

    Skidmore, Michael; Dede, Yemi U.; Moneta, Giovanni B.

    2009-01-01

    This study investigated the relationships between role models, approaches to studying, and self-efficacy in students attending a high school specialising in educating those with emotional and behavioural difficulties (EBD, n = 30) and students attending a mainstream high school (n = 41) in the UK. Types and quantity of role models held by students…

  1. A Response to Kauffman's The Devaluation of Special Education

    Science.gov (United States)

    Mostert, Mark P.

    2004-01-01

    Kauffman indicts the President's Commission on Excellence in Special Education (PCESE) for sometimes implying the opposite of its stated aim of helping children in special education, including students with EBD, as he believes does the No Child Left Behind act (NCLB, 2002). This response addresses (a) two pivotal, but implied aspects the PCESE and…

  2. Collecting Behavioral Data in General Education Settings: A Primer for Behavioral Data Collection

    Science.gov (United States)

    Lee, David L.; Vostal, Brooks; Lylo, Brooke; Hua, Youjia

    2011-01-01

    Recent trends toward the inclusion of students with disabilities mean that a majority of students with emotional and behavioral disorders (EBD) now spend at least 40% of their day in general education settings. With this change in location, teachers in general education settings are now asked to perform tasks that were not given much emphasis…

  3. Making the case for evidence-based design in healthcare: a descriptive case study of organizational decision making.

    Science.gov (United States)

    Shoemaker, Lorie K; Kazley, Abby Swanson; White, Andrea

    2010-01-01

    The aim of this study was to describe the organizational decision-making process used in the selection of evidence-based design (EBD) concepts, the criteria used to make these decisions, and the extent to which leadership style may have influenced the decision-making process. Five research questions were formulated to frame the direction of this study, including: (1) How did healthcare leaders learn of innovations in design? (2) How did healthcare leaders make decisions in the selection of healthcare design concepts? (3) What criteria did healthcare leaders use in the decision-making process? (4) How did healthcare leaders consider input from the staff in design decisions? and (5) To what extent did the leadership style of administrators affect the outcomes of the decision-making process? Current issues affecting healthcare in the community led the principal investigator's organization to undertake an ambitious facilities expansion project. As part of its planning process, the organization learned of EBD principles that seemingly had a positive impact on patient care and safety and staff working conditions. Although promising, a paucity of empirical research addressed the cost/benefit of incorporating many EBD concepts into one hospital setting, and there was no research that articulated the organizational decision-making process used by healthcare administrators when considering the use of EBD in expansion projects. A mixed-method, descriptive, qualitative, single-case study and quantitative design were used to address the five research questions. The Systems Research Organizing Model provided the theoretical framework. A variety of data collection methods was used, including interviews of key respondents, the review of documentary evidence, and the Multifactor Leadership Questionnaire. A participatory process was used throughout the design decision phases, involving staff at all levels of the organization. The Internet and architects facilitated learning about

  4. Refractory strictures despite steroid injection after esophageal endoscopic resection

    Science.gov (United States)

    Hanaoka, Noboru; Ishihara, Ryu; Uedo, Noriya; Takeuchi, Yoji; Higashino, Koji; Akasaka, Tomofumi; Kanesaka, Takashi; Matsuura, Noriko; Yamasaki, Yasushi; Hamada, Kenta; Iishi, Hiroyasu

    2016-01-01

    Background: Although steroid injection prevents stricture after esophageal endoscopic submucosal dissection (ESD), some patients require repeated sessions of endoscopic balloon dilation (EBD). We investigated the risk for refractory stricture despite the administration of steroid injections to prevent stricture in patients undergoing esophageal ESD. Refractory stricture was defined as the requirement for more than three sessions of EBD to resolve the stricture. In addition, the safety of steroid injections was assessed based on the rate of complications. Patients and methods: We analyzed data from 127 consecutive patients who underwent esophageal ESD and had mucosal defects with a circumferential extent greater than three-quarters of the esophagus. To prevent stricture, steroid injection was performed. EBD was performed whenever a patient had symptoms of dysphagia. Results: The percentage of patients with a tumor circumferential extent greater than 75 % was significantly higher in those with refractory stricture than in those without stricture (P = 0.001). Multivariate analysis adjusted for age, sex, history of radiation therapy, tumor location, and tumor diameter showed that a tumor circumferential extent greater than 75 % was an independent risk factor for refractory stricture (adjusted odds ratio [OR] 5.49 [95 %CI 1.91 – 15.84], P = 0.002). Major adverse events occurred in 3 patients (2.4 %): perforation during EBD in 2 patients and delayed perforation after EBD in 1 patient. The patient with delayed perforation underwent esophagectomy because of mediastinitis. Conclusions: A tumor circumferential extent greater than 75 % is an independent risk factor for refractory stricture despite steroid injections. The development of more extensive interventions is warranted to prevent refractory stricture. PMID:27004256

  5. Nanolaminates: increasing dielectric breakdown strength of composites.

    Science.gov (United States)

    Fillery, Scott P; Koerner, Hilmar; Drummy, Lawrence; Dunkerley, Erik; Durstock, Michael F; Schmidt, Daniel F; Vaia, Richard A

    2012-03-01

    Processable, low-cost, high-performance hybrid dielectrics are enablers for a vast array of green technologies, including high-temperature electrical insulation and pulsed power capacitors for all-electric transportation vehicles. Maximizing the dielectric breakdown field (E(BD)), in conjunction with minimization of leakage current, directly impacts system performance because of the field's quadratic relationship with electrostatic energy storage density. On the basis of the extreme internal interfacial area and ultrafine morphology, polymer-inorganic nanocomposites (PNCs) have demonstrated modest increases in E(BD) at very low inorganic loadings, but because of insufficient control of the hierarchal morphology of the blend, have yielded a precipitous decline in E(BD) at intermediate and high inorganic volume fractions. Here in, we demonstrate that E(BD) can be increased up to these intermediate inorganic volume fractions by creating uniform one-dimensional nanocomposites (nanolaminates) rather than blends of spherical inorganic nanoparticles and polymers. Free standing nanolaminates of highly aligned and dispersed montmorillonite in polyvinyl butyral exhibited enhancements in E(BD) up to 30 vol % inorganic (70 wt % organically modified montmorillonite). These relative enhancements extend up to five times the inorganic fraction observed for random nanoparticle dispersions, and are anywhere from two to four times greater than observed at comparable volume fraction of nanoparticles. The breakdown characteristics of this model system suggested a trade-off between increased path tortuosity and polymer-deficient structural defects. This implies that an idealized PNC morphology to retard the breakdown cascade perpendicular to the electrodes will occur at intermediate volume fractions and resemble a discotic nematic phase where highly aligned, high-aspect ratio nanometer thick plates are uniformly surrounded by nanoscopic regions of polymer.

  6. Mirror neuron dysfunction and ego-boundary disturbances in schizophrenia: A transcranial magnetic stimulation study

    Directory of Open Access Journals (Sweden)

    Rakshathi Basavaraju

    2015-01-01

    Full Text Available Background: Ego-boundary disturbance (EBD is a unique symptom cluster characterized by passivity experiences (involving thoughts, actions, emotions and sensations attributed by patients to some external agency. The neurobiology of these "first rank" symptoms is poorly understood. Aberrant mirror neuron activation may explain impaired self-monitoring and agency attribution underlying these symptoms. We aim to study mirror neuron activity (MNA in schizophrenia patients with and without EBD using transcranial magnetic stimulation (TMS. Materials and Methods: 50 right-handed schizophrenia patients (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition were evaluated using the Mini-International Neuropsychiatric Interview and the Positive and Negative Syndrome Scale. They completed a TMS experiment to assess putative premotor MNA. Motor evoked potential (MEP was recorded in the right first dorsal interosseous muscle (FDI with (a 120% of resting motor threshold (RMT, (b stimulus intensity set to evoke MEP of motor threshold 1 mV amplitude (MT1, (c two paired pulse paradigms (short- and long interval intra-cortical inhibition. These were done in three states: Actual observation of an action using the FDI, virtual-observation (video of this action and resting state. The percent change of MEP from resting to action-observation states formed the measure of putative MNA. Results: MNA measured using MT1 and 120% RMT paradigms was significantly lower in the 18 patients with EBD (thought-broadcast/withdrawal/insertion, made-act/impulse/affect and somatic passivity than the 32 patients without EBD (t = 2.431, P = 0.020; t = 2.051, P = 0.04 respectively for the two paradigms. The two groups did not differ on age, gender, education and total symptom scores. Conclusion: Schizophrenia patients with EBD have lower premotor MNA. This highlights the role of MNA dysfunction in the pathophysiology of this unique and intriguing symptom cluster in

  7. Evidence-Based Dentistry: The Next Frontier in Translational and Trans-National Dental Practice

    Directory of Open Access Journals (Sweden)

    Reem Ajaj

    2011-04-01

    Full Text Available Evidence-Based Dentistry (EBD is a systematic approach for ob-taining the best available clini-cally relevant scientific evidence with the ultimate goal and intent of increasing effectiveness and efficacy in clinical decision-making. EBD pursues optimizing both the patient’s benefit through the best utilization of dentist’s experience and clinical expertise, and on making full use of the most reliable and va-lid research outcomes. EBD is initiated by the patient-dentist interaction, which is translated into a patient-centered P.I.C.O. question. The resulting literature bibliome is assessed and quantified for the level and quality of the evidence by means of fully validated and reli-able instruments based on common standard criteria of research methodology, design and statistical analysis. The outcomes are evaluated by acceptable sampling analysis, Such that studies, whose flaws have been identified to result potentially into misleading infor-mation to the patients and/or practitioner may be judiciously removed from further consideration". The research synthesis process tests for overarching statistical sig-nificance among non-heterogeneous outcomes, and yields a consensus of the best available evidence. The systematic nature of the re-search review and synthesis that characterizes EBD is reported in the literature as “systematic reviews”, “complex systematic reviews”, or “clinically relevant complex systematic reviews”. Thus the reported best available evidence ensures patient-centered clinical decision for interventions of the highest possible effectiveness and effi-cacy. EBD contrasts with traditional dentistry based on the evidence for its systematic stringency, coupled with its fundamental validity as a patient-centered optimization of clinical modes of interventions.

  8. Mirror neuron dysfunction and ego-boundary disturbances in schizophrenia: a transcranial magnetic stimulation study.

    Science.gov (United States)

    Basavaraju, Rakshathi; Mehta, Urvakhsh Meherwan; Thirthalli, Jagadisha; Gangadhar, Bangalore N

    2015-01-01

    Ego-boundary disturbance (EBD) is a unique symptom cluster characterized by passivity experiences (involving thoughts, actions, emotions and sensations) attributed by patients to some external agency. The neurobiology of these "first rank" symptoms is poorly understood. Aberrant mirror neuron activation may explain impaired self-monitoring and agency attribution underlying these symptoms. We aim to study mirror neuron activity (MNA) in schizophrenia patients with and without EBD using transcranial magnetic stimulation (TMS). 50 right-handed schizophrenia patients (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) were evaluated using the Mini-International Neuropsychiatric Interview and the Positive and Negative Syndrome Scale. They completed a TMS experiment to assess putative premotor MNA. Motor evoked potential (MEP) was recorded in the right first dorsal interosseous muscle (FDI) with (a) 120% of resting motor threshold (RMT), (b) stimulus intensity set to evoke MEP of motor threshold 1 mV amplitude (MT1), (c) two paired pulse paradigms (short- and long interval intra-cortical inhibition). These were done in three states: Actual observation of an action using the FDI, virtual-observation (video) of this action and resting state. The percent change of MEP from resting to action-observation states formed the measure of putative MNA. MNA measured using MT1 and 120% RMT paradigms was significantly lower in the 18 patients with EBD (thought-broadcast/withdrawal/insertion, made-act/impulse/affect and somatic passivity) than the 32 patients without EBD (t = 2.431, P = 0.020; t = 2.051, P = 0.04 respectively for the two paradigms). The two groups did not differ on age, gender, education and total symptom scores. Schizophrenia patients with EBD have lower premotor MNA. This highlights the role of MNA dysfunction in the pathophysiology of this unique and intriguing symptom cluster in schizophrenia.

  9. Achalasia: advances in treatment.

    Science.gov (United States)

    Schoenberg, Markus Bo; Vassiliou, Melina Catherine; von Renteln, Daniel

    2014-09-01

    Achalasia is a primary esophageal motility disorder, which shows distinct clinical, manometric, radiologic, and pathologic features. Available treatment strategies are pharmacological, endoscopic or surgical. In the past decades preferred treatment has alternated between surgical myotomy (presently Laparoscopic Heller Myotomy [LHM]) and endoscopic balloon dilation (EBD). While surgical myotomy promises superior long-term results and significantly less retreatment, endoscopic balloon dilation is initially far less invasive and yields comparable results after redilation. Peroral Endoscopic Myotomy (POEM) aims to combine the minimal invasive approach through the mouth with the better long-term results after LHM. Initial findings in the literature point to comparable success-rates after POEM and LHM. In the literature complication rates are similar to those obtained after surgery. This new interventional technique should be subject to randomized controlled trials and compared to EBD and LHM.

  10. 2nd International Workshop on Evidence-Based Technology Enhanced Learning

    CERN Document Server

    Gennari, Rosella; Marenzi, Ivana; Mascio, Tania; Prieta, Fernando

    2013-01-01

    Research on Technology Enhanced Learning (TEL) investigates how information and communication technologies can be designed in order to support pedagogical activities. The Evidence Based Design (EBD) of a system bases its decisions on empirical evidence and effectiveness. The evidence-based TEL workshop (ebTEL) brings together TEL and EBD.   The first edition of ebTEL collected contributions in the area of TEL from computer science, artificial intelligence, evidence-based medicine, educational psychology and pedagogy. Like the previous edition, this second edition, ebTEL’13, wants to be a forum in which TEL researchers and practitioners alike can discuss innovative evidence-based ideas, projects, and lessons related to TEL.   The workshop took place in Salamanca, Spain, on May 22nd-24th 2013.  

  11. Using architecture and technology to promote improved quality of life for military service members with traumatic brain injury.

    Science.gov (United States)

    Pasquina, Paul F; Pasquina, Lavinia Fici; Anderson-Barnes, Victoria C; Giuggio, Jeffrey S; Cooper, Rory A

    2010-02-01

    Today, injured service members are surviving wounds that would have been fatal in previous wars. A recent RAND report estimates that approximately 320,000 service members may have experienced a traumatic brain injury (TBI) during deployment, and it is not uncommon for a soldier to sustain multiple associated injuries such as limb loss, paralysis, sensory loss, and psychological damage. As a result, many military service members and their families face significant challenges returning to a high quality of independent life. The architectural concepts of universal design (UD) and evidence-based design (EBD) are gaining interest as an integral part of the rehabilitation process of veterans with TBI. This article examines the possibilities presented by UD and EBD in accordance with the Americans with Disabilities Act of 1990, in terms of high-end building and interior design quality, and possible technological options for individuals with disabilities.

  12. Using the experience-based design approach to improve orthodontic care.

    Science.gov (United States)

    Ellis, Pamela E; Silverton, Sarah

    2014-12-01

    The experience-based design (ebd) approach is a method of measuring patient experience, which deliberately draws out subjective, emotional and personal feelings of the patients using a service. We describe how the experience-based design approach has been used to measure the experiences of teenage patients at orthodontic consultation appointments in a district general hospital. This has allowed us to identify the points in the patient's journey where they experience most anxiety and nervousness and to target service improvements in these areas. We found the ebd approach effective in measuring patient experience in a teenage patient population. We demonstrate how the service improvements implemented have reduced negative feelings during new patient consultations.

  13. Evidence Locator: sources of evidence-based dentistry information.

    Science.gov (United States)

    Frantsve-Hawley, Julie

    2008-09-01

    Multiple resources are available to help practitioners access the latest scientific evidence. Evidence-based dentistry (EBD) is an approach to clinical decision making that incorporates the most current and comprehensive scientific evidence with the practitioner's judgment and the patient's needs and preferences. One challenge in implementing this approach is access to evidence, and there are multiple online resources that can be used in this endeavor. This article presents the Evidence Locator, a list of Web sites that provide access to "secondary sources" of evidence. Such "secondary sources" are typically summaries of systematic reviews and evidence-based clinical recommendations or guidelines. Also presented is a list of other Web sites that may be useful to the practitioner in implementing EBD.

  14. Primer of statistics in dental research: part I.

    Science.gov (United States)

    Shintani, Ayumi

    2014-01-01

    Statistics play essential roles in evidence-based dentistry (EBD) practice and research. It ranges widely from formulating scientific questions, designing studies, collecting and analyzing data to interpreting, reporting, and presenting study findings. Mastering statistical concepts appears to be an unreachable goal among many dental researchers in part due to statistical authorities' limitations of explaining statistical principles to health researchers without elaborating complex mathematical concepts. This series of 2 articles aim to introduce dental researchers to 9 essential topics in statistics to conduct EBD with intuitive examples. The part I of the series includes the first 5 topics (1) statistical graph, (2) how to deal with outliers, (3) p-value and confidence interval, (4) testing equivalence, and (5) multiplicity adjustment. Part II will follow to cover the remaining topics including (6) selecting the proper statistical tests, (7) repeated measures analysis, (8) epidemiological consideration for causal association, and (9) analysis of agreement.

  15. LOS MODELOS DE ADQUISICIÓN Y ENSEÑANZA EN UNA SEGUNDA LENGUA, Y LA HIPÓTESIS DEL FILTRO AFECTIVO DE KRASHEN

    OpenAIRE

    Hamdan Al Shehri

    2012-01-01

    Theories of acquisition and learning in second language and Krashen’s affective filter hypothesis. There has been considerable research on some factors influencing academic performance of students based on emotional and behavioural disabilities/disorders (EBD) regarding academic achievement. Stephen Krashen tackles this problem from his theory of second language acquisition, called the monitor hypothesis, where he considers up to nine different hypotheses, among which, is the affective fil...

  16. Children with emotional and behavioral disorders in special education: Placement, progress, and family functioning

    OpenAIRE

    Stoutjesdijk, Regina

    2014-01-01

    The studies described in this dissertation focus on children with emotional and behavioral disorders (EBD) in special education. It was found that poor academic performance, relational problems between children and caregivers, and the age at which youth care was involved for the first time predicted placement in a more restrictive special educational setting over placement in a regular school. No differences in progress outcomes regarding behavioral functioning and academic performance of chi...

  17. Evidence-Based and Value-Based Decision Making About Healthcare Design: An Economic Evaluation of the Safety and Quality Outcomes.

    Science.gov (United States)

    Zadeh, Rana; Sadatsafavi, Hessam; Xue, Ryan

    2015-01-01

    This study describes a vision and framework that can facilitate the implementation of evidence-based design (EBD), scientific knowledge base into the process of the design, construction, and operation of healthcare facilities and clarify the related safety and quality outcomes for the stakeholders. The proposed framework pairs EBD with value-driven decision making and aims to improve communication among stakeholders by providing a common analytical language. Recent EBD research indicates that the design and operation of healthcare facilities contribute to an organization's operational success by improving safety, quality, and efficiency. However, because little information is available about the financial returns of evidence-based investments, such investments are readily eliminated during the capital-investment decision-making process. To model the proposed framework, we used engineering economy tools to evaluate the return on investments in six successful cases, identified by a literature review, in which facility design and operation interventions resulted in reductions in hospital-acquired infections, patient falls, staff injuries, and patient anxiety. In the evidence-based cases, calculated net present values, internal rates of return, and payback periods indicated that the long-term benefits of interventions substantially outweighed the intervention costs. This article explained a framework to develop a research-based and value-based communication language on specific interventions along the planning, design and construction, operation, and evaluation stages. Evidence-based and value-based design frameworks can be applied to communicate the life-cycle costs and savings of EBD interventions to stakeholders, thereby contributing to more informed decision makings and the optimization of healthcare infrastructures. © The Author(s) 2015.

  18. Classroom-BasedFunctional Analysis and Intervention for Students with Emotional/Behavioral Disorders

    OpenAIRE

    Wright-Gallo, G. L.; Higbee, Thomas S.; Reagon, K. A.; Davey, B. J.

    2006-01-01

    We conducted functional analyses of disruptive behavior in a classroom setting for two students of typical intelligence with emotional/behavioral disorders (E/BD) using the classroom teacher to implement functional analysis conditions. The functional analyses suggested that both participants' disruptive behavior was maintained by escape from task demands and access to attention. Based on this information, we implemented a DRA procedure in which participants could request either escape or atte...

  19. Introduction to the basics of evidence-based dentistry: concepts and skills.

    Science.gov (United States)

    Forrest, Jane L

    2009-09-01

    The purpose of this section of the ADA Champions Pre-Conference is to review the basics of Evidence-based dentistry (EBD), research designs and levels of evidence, and identify the skills necessary for clinicians to efficiently use an evidence-based approach in practice. This session of the pre-conference preceded the session on the skills needed to define a clinical question and search for the evidence to answer that question.

  20. Brzdové systémy motorových vozidel

    OpenAIRE

    Brychta, Jan

    2015-01-01

    This bachelor thesis deal with the current state in construction and development trends of cars brake systems. The introduction shows the development and reason for using of brake systems for trucks. Furthermore, the general division and current trends in brake systems, such as EBS - Electronic Braking System with subsystems: EPB - Electro - Pneumatic Brake, ABS - Anti-lock Braking System, ASR - Anti-Slip Regula-tion, ESP - Electronic Stability Program, EBD - Electronic Brakeforce Distributio...

  1. Research in dentistry: Question, search and studies design.

    OpenAIRE

    Pedro Aravena

    2012-01-01

    Evidence-based dentistry (EBD) concept has caused great impact and interest in the field of dentistry. For its development is important to use research protocols and study designs according to the research problem. The aim of this review is to present basic aspects for the start of a quantitative research in dentistry.It presents the topics necessary to transform a research problem to a question with clinical approach. Then, concepts about finding relevant scientific articles in the electroni...

  2. Interaction of wall shear stress magnitude and gradient in the prediction of arterial macromolecular permeability.

    Science.gov (United States)

    LaMack, Jeffrey A; Himburg, Heather A; Li, Xue-Mei; Friedman, Morton H

    2005-04-01

    Large spatial shear stress gradients have anecdotally been associated with early atherosclerotic lesion susceptibility in vivo and have been proposed as promoters of endothelial cell dysfunction in vitro. Here, experiments are presented in which several measures of the fluid dynamic shear stress, including its gradient, at the walls of in vivo porcine iliac arteries, are correlated against the transendothelial macromolecular permeability of the vessels. The fluid dynamic measurements are based on postmortem vascular casts, and permeability is measured from Evans blue dye (EBD) uptake. Time-averaged wall shear stress (WSS), as well as a new parameter termed maximum gradient stress (MGS) that describes the spatial shear stress gradient due to flow acceleration at a given point, are mapped for each artery and compared on a point-by-point basis to the corresponding EBD patterns. While there was no apparent relation between MGS and EBD uptake, a composite parameter, WSS(-0.11) MGS(0.044), was highly correlated with permeability. Notwithstanding the small exponents, the parameter varied widely within the region of interest. The results suggest that sites exposed to low wall shear stresses are more likely to exhibit elevated permeability, and that this increase is exacerbated in the presence of large spatial shear stress gradients.

  3. Antifungal Activity and Nail Permeation of Nail Lacquer Containing Piper regnellii (Miq. C. CD. var. pallescens (C. DC. Yunck (Piperaceae Leave Extracts and Derivatives

    Directory of Open Access Journals (Sweden)

    Andrea Mayumi Koroishi

    2010-06-01

    Full Text Available The dermatophytes are filamentous fungi that cause cutaneous fungal infections because they use keratin as a nutrient source. For this study the antidermatophyte activity of the extracts and derivates from leaves of Piper regnellii was analyzed. From the dichloromethane extract (EBD neolignans such as eupomatenoid-3 and eupomatenoid-5 were obtained, and it was submitted to fractionation to remove the green residue, designated as the chloroform fraction (FF. Extracts, chloroform fraction and compounds were tested against Trichophyton rubrum ATCC 28189 to determine the minimum inhibitory concentration (MIC. The chloroform fraction was incorporated to nail lacquer that was analyzed by photoacoustic spectroscopy, in vitro assay and scanning electronic microscopy. For antifungal activity in solid medium the dichloromethane extract and chloroform fraction were used. The compounds eupomatenoid-3 and eupomatenoid-5 were less active than the dichloromethane extract against T. rubrum. EBD and FF showed moderate activity in hyphal growth inhibition in solid medium and EBD did not link to ergosterol. Nail lacquer containing the chloroform fraction showed good penetration through the nail as determined by photoacoustic spectroscopy. From in vitro studies it was observed that nail lacquer concentrations above 20 mg/mL prevented the growth of fungi, but concentrations up to 2.5 inhibited the growth. Scanning electronic microscopy was used to confirm the in vitro nail lacquer activity results. The specie P. regnellii showed great antifungal activity against T. rubrum, and nail lacquer containing its chloroform fraction has great potential to treat onychomycosis caused by these microorganisms.

  4. Making the Case for Practice-Based Research and the Imperative Role of Design Practitioners.

    Science.gov (United States)

    Freihoefer, Kara; Zborowsky, Terri

    2017-04-01

    The purpose of this article is to justify the need for evidence-based design (EBD) in a research-based architecture and design practice. This article examines the current state of practice-based research (PBR), supports the need for EBD, illustrates PBR methods that can be applied to design work, and explores how findings can be used as a decision-making tool during design and as a validation tool during postoccupancy. As a result, design professions' body of knowledge will advance and practitioners will be better informed to protect the health, safety, and welfare of the society. Furthermore, characteristics of Friedman's progressive research program are used as a framework to examine the current state of PBR in design practice. A modified EBD approach is proposed and showcased with a case study of a renovated inpatient unit. The modified approach demonstrates how a highly integrated project team, especially the role of design practitioners, contributed to the success of utilizing baseline findings and evidence in decision-making throughout the design process. Lastly, recommendations and resources for learning research concepts are provided for practitioners. It is the role of practitioners to pave the way for the next generation of design professionals, as the request and expectation for research become more prevalent in design practice.

  5. Endoscopic biliary drainage for choledocholithiasis in a patient with aplastic anemia before hematological engraftment after allogeneic transplantation.

    Science.gov (United States)

    Okada, Kohei; Hashino, Satoshi; Takahata, Mutsumi; Onozawa, Masahiro; Kahata, Kaoru; Kondo, Takeshi; Imamura, Masahiro; Asaka, Masahiro

    2009-05-01

    A 30-year-old man was diagnosed with severe aplastic anemia in 1997. He received mPSL pulse therapy and was treated with ATG and cyclosporine, resulting in remission and exacerbation; however, his pancytopenia gradually progressed and transfusions were required. He was referred to our hospital for further treatment by allogeneic bone marrow transplantation (allo-BMT). Before allo-BMT, he suffered febrile neutropenia. His white blood cell count was asymptomatic stones in his gallbladder (GB) and common bile duct (CBD) by a screening test before allo-BMT, we decided to remove the stones after BMT because of his severe neutropenia. He underwent allo-BMT from an HLA-matched unrelated donor after conditioning with a reduced-intensity regimen. On day 9 after BMT, he developed acute obstructive suppurative cholangitis. Germ-free care was transiently stopped and endoscopic biliary drainage (EBD) was performed for the stones in the common bile duct. Engraftment of WBC was confirmed on day 24, and the stones were removed using endoscopic sphincterotomy on day 57 after confirmation of platelet recovery. We could perform EBD safely before hematological engraftment. A strategy for the management of asymptomatic stones of the GB and CBD has not yet been established. The possibility of removing stones before BMT should therefore be considered. Consideration should also be given to the possibility of improving acute obstructive suppurative cholangitis by EBD and antibiotics before hematological engraftment in such cases when stones cannot be removed before BMT.

  6. Creating an evidence-based dentistry culture at Baylor College of Dentistry: the winds of change.

    Science.gov (United States)

    Hinton, Robert J; Dechow, Paul C; Abdellatif, Hoda; Jones, Daniel L; McCann, Ann L; Schneiderman, Emet D; D'Souza, Rena

    2011-03-01

    In the early years of the new millennium, the National Institute of Dental and Craniofacial Research of the National Institutes of Health began funding Oral Health Research Education Grants using the R25 mechanism to promote the application of basic and clinical research findings to clinical training and to encourage students to pursue careers in oral health research. This report describes the impact of an R25 grant awarded to the Texas A&M Health Science Center's Baylor College of Dentistry (BCD) on its curriculum and faculty development efforts. At BCD, the R25 grant supports a multipronged initiative that employs clinical research as a vehicle for acquainting both students and faculty with the tools of evidence-based dentistry (EBD). New coursework and experiences in all four years of the curriculum plus a variety of faculty development offerings are being used to achieve this goal. Progress on these fronts is reflected in a nascent EBD culture characterized by increasing participation and buy-in by students and faculty. The production of a new generation of dental graduates equipped with the EBD skill set as well as a growing nucleus of faculty members who can model the importance of evidence-based practice is of paramount importance for the future of dentistry.

  7. Evidence-based dentistry as it relates to dental materials.

    Science.gov (United States)

    Bayne, Stephen C; Fitzgerald, Mark

    2014-01-01

    Evidence-based dentistry (EBD) is reviewed in depth to underscore the limitations for evidence-based dental materials information that exist at this time. Anecdotal estimates of evidence for dental practice are in the range of 8 percent to 10 percent. While the process of evaluating the literature base for dental evidence began 20 years ago, it was not practical to implement it until high-speed wireless connections, open access to journals, and omnipresent connections via smart phones became a reality. EBD includes five stages of information collection and analysis, starting with a careful definition of a clinical question using the PICO(T) approach. Clinical evidence in randomized control trials is considered the best. Clinical trial perspectives (prospective, cross-sectional, retrospective) and outcome designs (RCTs, SCTs, CCTs, cohort studies, case-control studies) are quite varied. Aggregation techniques (including meta-analyses) allow meaningful combinations of clinical data from trials with similar designs but with fewer rigors. Appraisals attempt to assess the entire evidence base without bias and answer clinical questions. Varying intensities to these approaches, Cochrane Collaboration, ADA-EBD Library, UTHSCSA CATs Library, are used to answer questions. Dental materials evidence from clinical trials is infrequent, short-term, and often not compliant with current guidelines (registration, CONSORT, PRISMA). Reports in current evidence libraries indicate less than 5 percent of evidence is related to restorative dental materials.

  8. The evidence-based dentistry initiative at Baylor College of Dentistry.

    Science.gov (United States)

    Jones, Daniel L; Hinton, Robert J; Dechow, Paul C; Abdellatif, Hoda; McCann, Ann L; Schneiderman, Emet D; D'Souza, Rena

    2011-02-01

    This report describes the impact of an R25 Oral Health Research Education Grant awarded to the Texas A&M Health Science Center-Baylor College of Dentistry (BCD) to promote the application of basic and clinical research findings to clinical training and encourage students to pursue careers in oral health research. At Baylor, the R25 grant supports a multi-pronged initiative that employs clinical research as a vehicle for acquainting both students and faculty with the tools of evidence-based dentistry (EBD). New coursework and experiences in all 4 years of the curriculum plus a variety of faculty development offerings are being used to achieve this goal. Progress on these fronts is reflected in a nascent "EBD culture" characterized by increasing participation and buy-in by students and faculty. The production of a new generation of dental graduates equipped with the EBD skill set as well as a growing nucleus of faculty who can model the importance of evidence-based practice is of paramount importance for the future of dentistry.

  9. An approach to define semantics for BPM systems interoperability

    Science.gov (United States)

    Rico, Mariela; Caliusco, María Laura; Chiotti, Omar; Rosa Galli, María

    2015-04-01

    This article proposes defining semantics for Business Process Management systems interoperability through the ontology of Electronic Business Documents (EBD) used to interchange the information required to perform cross-organizational processes. The semantic model generated allows aligning enterprise's business processes to support cross-organizational processes by matching the business ontology of each business partner with the EBD ontology. The result is a flexible software architecture that allows dynamically defining cross-organizational business processes by reusing the EBD ontology. For developing the semantic model, a method is presented, which is based on a strategy for discovering entity features whose interpretation depends on the context, and representing them for enriching the ontology. The proposed method complements ontology learning techniques that can not infer semantic features not represented in data sources. In order to improve the representation of these entity features, the method proposes using widely accepted ontologies, for representing time entities and relations, physical quantities, measurement units, official country names, and currencies and funds, among others. When the ontologies reuse is not possible, the method proposes identifying whether that feature is simple or complex, and defines a strategy to be followed. An empirical validation of the approach has been performed through a case study.

  10. Introducing evidence-based dentistry to dental students using histology.

    Science.gov (United States)

    Lallier, Thomas E

    2014-03-01

    The expansion of evidence-based dentistry (EBD) is essential to the continued growth and development of the dental profession. Expanding EBD requires increased emphasis on critical thinking skills during dental education, as noted in the American Dental Education Association's Competencies for the New General Dentist. In order to achieve this goal, educational exercises must be introduced to increase the use of critical thinking skills early in the dental curriculum, with continued reinforcement as students progress through subsequent years. Described in this article is one approach to increasing student exposure to critical thinking during the early basic science curriculum-specifically, within the confines of a traditional histology course. A method of utilizing the medical and dental research literature to reinforce and enliven the concepts taught in histology is described, along with an approach for using peer-to-peer presentations to demonstrate the tools needed to critically evaluate research studies and their presentation in published articles. This approach, which could be applied to any basic science course, will result in a stronger foundation on which students can build their EBD and critical thinking skills.

  11. A Dynamic Programming Algorithm For (1,2)-Exemplar Breakpoint Distance.

    Science.gov (United States)

    Wei, Zhexue; Zhu, Daming; Wang, Lusheng

    2015-07-01

    The exemplar breakpoint distance problem is motivated by finding conserved sets of genes between two genomes. It asks to find respective exemplars in two genomes to minimize the breakpoint distance between them. If one genome has no repeated gene (called trivial genome) and the other has genes repeating at most twice, it is referred to as the (1, 2)-exemplar breakpoint distance problem, EBD(1, 2) for short. Little has been done on algorithm design for this problem by now. In this article, we propose a parameter to describe the maximum physical span between two copies of a gene in a genome, and based on it, design a fixed-parameter algorithm for EBD(1, 2). Using a dynamic programming approach, our algorithm can take O(4(s)n(2)) time and O(4(s)n) space to solve an EBD(1, 2) instance that has two genomes of n genes where the second genome has each two copies of a gene spanning at most s copies of the genes. Our algorithm can also be used to compute the maximum adjacencies between two genomes. The algorithm has been implemented in C++. Simulations on randomly generated data have verified the effectiveness of our algorithm. The software package is available from the authors.

  12. Evidence-based dentistry.

    Science.gov (United States)

    Chambers, David W

    2010-01-01

    Both panegyric and criticism of evidence-based dentistry tend to be clumsy because the concept is poorly defined. This analysis identifies several contributions to the profession that have been made under the EBD banner. Although the concept of clinicians integrating clinical epidemiology, the wisdom of their practices, and patients' values is powerful, its implementation has been distorted by a too heavy emphasis of computerized searches for research findings that meet the standards of academics. Although EBD advocates enjoy sharing anecdotal accounts of mistakes others have made, faulting others is not proof that one's own position is correct. There is no systematic, high-quality evidence that EBD is effective. The metaphor of a three-legged stool (evidence, experience, values, and integration) is used as an organizing principle. "Best evidence" has become a preoccupation among EBD enthusiasts. That overlong but thinly developed leg of the stool is critiqued from the perspectives of the criteria for evidence, the difference between internal and external validity, the relationship between evidence and decision making, the ambiguous meaning of "best," and the role of reasonable doubt. The strongest leg of the stool is clinical experience. Although bias exists in all observations (including searches for evidence), there are simple procedures that can be employed in practice to increase useful and objective evidence there, and there are dangers in delegating policy regarding allowable treatments to external groups. Patient and practitioner values are the shortest leg of the stool. As they are so little recognized, their integration in EBD is problematic and ethical tensions exist where paternalism privileges science over patient's self-determined best interests. Four potential approaches to integration are suggested, recognizing that there is virtually no literature on how the "seat" of the three-legged stool works or should work. It is likely that most dentists

  13. Evidence-Based Design in Nederlandse ziekenhuizen: Ruimtelijke kwaliteiten die van invloed zijn op het welbevinden en de gezondheid van patiënten

    Directory of Open Access Journals (Sweden)

    Marie Helene Herweijer-van Gelder

    2016-04-01

    Full Text Available SubjectEvidence-Based Design in hospitals.ProblemWhat role can Evidence-Based Design have in the design of better hospitals?PurposeTo determine spatial (or: concrete qualities, scientifically proven to have a positive influence on the health and well being of patients and staff, in order to offer the architect a helping hand for designing better hospitals. These measures are drawn from research that has been done in the framework of Evidence-Based Design (EBD, which can be perceived as the scientific variant of the healing environment.RelevanceIn the Dutch media the term healing environment is often used by architects, representatives of hospitals and researchers. Everyone provides their own content (colour, nature, treatment, hospitality, etc. to this collective concept. The determination of concrete design elements, with a proven positive effect for patients, can contribute to the design of better care environments.Method and approachLiterature research and case studies.EBD → elements → checklist → case studies in field research↑ ---------- analysis ---------- ↑Spatial measures were selected from scientific articles from Evidence-Based Design research that are applicable for an architect. Only those measures were selected for which the effect has been proven sufficiently. The selection was based on scientific articles that have been validated by EBD expert teams. The measures in this study cover waiting rooms, consultation rooms, nursing departments, patient rooms and day treatment areas.The measures have an effect on:A positive contribution to the health of patients (chapter 3;A positive contribution to the well being (less anxiety, stress of patients (chapter 4;A positive contribution to the efficiency and effectiveness of staff (chapter 5. The literature research gives information on how physical environmental interventions can contribute to the problems of the patient (such as lack of sleep. The selected measures are gathered in

  14. 收入公平、教育、生态-幸福效率与环境造成的疾病负担的实证分析%AN EMPIRICAL TEST ON INCOME EQUALITY,ECO-HAPPINESSEFFICIENCY AND ENVIRONMENTAL BURDEN OF DISEASE

    Institute of Scientific and Technical Information of China (English)

    刘桂芳; 刘雅晴

    2012-01-01

    研究了经济增长方式对人们健康的影响,选用环境造成的疾病负担作为应变量,实证分析了该指标与收入、收入公平、教育、生态-幸福效率等自变量的关系,从理论的角度证明了经济增长是环境造成的疾病负担减轻的一个必要条件,但更强调了其他变量(收入公平、教育、生态-幸福效率)与应变量的相关关系.研究表明:社会分配越公平、教育普及程度和生态-幸福效率越高,环境造成的疾病负担越低,从而证明了一个国家的经济发展方式对国民健康有实质的影响.%This paper mainly study the way how the economic growth mode put effects on human health. We uses EBD (Environmental Burden of Disease) as the dependant variable, empirically tests the relationship between EBD and income, income distribution, eco-happiness-efficiency and education. It theorizes that economic growth is a necessary condition for reducing environmental burden of disease, but it also stresses that other variables, such as income distribution, education, and eco-happiness-efficiency, have close association with EBD. At last, we make the conclusion that more equitable income distribution, higher eco-happiness-efficiency and more universal education will lead to the lower level of environmental burden of disease, which implies that the way a country boosts its economy can impose essential impact on people's health.

  15. International Workshop on Evidence-Based Technology Enhanced Learning

    CERN Document Server

    Gennari, Rosella; Marenzi, Ivana; Prieta, Fernando; Rodríguez, Juan

    2012-01-01

    Research on Technology Enhanced Learning (TEL) investigates how information and communication technologies can be designed in order to support pedagogical activities. The workshop proceedings collects contributions concerning evidence based TEL systems, like their design following EBD principles as well as studies or best practices that educators, education stakeholders or psychologists used to diagnose or improve their students' learning skills, including students with specific difficulties. The international ebTEL’12 workshop wants to be a forum in which TEL researchers and practitioners alike can discuss ideas, projects, and lessons related to ebTEL. The workshop takes place in Salamanca, Spain, on March 28th-30th 2012.  

  16. Quantification of biventricular myocardial function using cardiac magnetic resonance feature tracking, endocardial border delineation and echocardiographic speckle tracking in patients with repaired tetralogy of fallot and healthy controls

    Directory of Open Access Journals (Sweden)

    Kempny Aleksander

    2012-05-01

    Full Text Available Abstract Background Parameters of myocardial deformation have been suggested to be superior to conventional measures of ventricular function in patients with tetralogy of Fallot (ToF, but have required non-routine, tagged cardiovascular magnetic resonance (CMR techniques. We assessed biventricular myocardial function using CMR cine-based feature tracking (FT and compared it to speckle tracking echocardiography (STE and to simple endocardial border delineation (EBD. In addition, the relation between parameters of myocardial deformation and clinical parameters was assessed. Methods Overall, 28 consecutive adult patients with repaired ToF (age 40.4 ± 13.3 years underwent standard steady-state-free precession sequence CMR, echocardiography, and cardiopulmonary exercise testing. In addition, 25 healthy subjects served as controls. Myocardial deformation was assessed by CMR based FT (TomTec Diogenes software, CMR based EBD (using custom written software and STE (TomTec Cardiac Performance Analysis software. Results Feature tracking was feasible in all subjects. A close agreement was found between measures of global left (LV and right ventricular (RV global strain. Interobserver agreement for FT and STE was similar for longitudinal LV global strain, but FT showed better inter-observer reproducibility than STE for circumferential or radial LV and longitudinal RV global strain. Reproducibility of regional strain on FT was, however, poor. The relative systolic length change of the endocardial border measured by EBD yielded similar results to FT global strain. Clinically, biventricular longitudinal strain on FT was reduced compared to controls (P 2-slope. Conclusions Although neither the inter-study reproducibility nor accuracy of FT software were investigated, and its inter-observer reproducibility for regional strain calculation was poor, its calculations of global systolic strain showed similar or better inter-oberver reproducibility than those

  17. A new species of Aphis Linnaeus, 1758 (Hem. Aphididae collected on Gymnophyton Clos (Apiaceae in Argentina

    Directory of Open Access Journals (Sweden)

    Sara I. López Ciruelos

    2017-02-01

    Full Text Available Aphis cuyana López Ciruelos & Ortego, sp. n. (Aphididae, Aphidinae is described from apterous and alate viviparous females collected on Gymnophyton polycephalum (Apiaceae in localities of the Argentinean provinces of La Rioja, San Juan and Mendoza. A table with differences of the apterous viviparous females of the new species from the species of Aphis and its close genera Andinaphis and Protaphis known in South America is presented. http://urn:lsid:zoobank.org:pub:4834FEF4-171C-4EBD-BF91-2137B517491E

  18. Effects of buffer layer and thermal annealing on the performance of hybrid Cu2S/PVK electrically bistable devices

    Science.gov (United States)

    Li, Xu; Lu, Yue; Guan, Li; Li, Jiantao; Wang, Yichao; Dong, Guoyi; Tang, Aiwei; Teng, Feng

    2016-09-01

    Hybrid organic/inorganic electrically bistable devices (EBDs) based on Cu2S/PVK nanocomposites have been fabricated by using a simple spin-coating method. An obvious electrical bistability is observed in the current-voltage (I-V) characteristics of the devices, and the presence of the buffer layer and the annealing process have an important effect on the enhancement of the ON/OFF current ratios. Different electrical conduction mechanisms are responsible for the charge switching of the devices in the presence and absence of the buffer layer.

  19. Sphincterotomy with endoscopic biliary drainage for severe acute cholangitis: a meta-analysis

    Science.gov (United States)

    Sawas, Tarek; Arwani, Noura; Al Halabi, Shadi; Vargo, John

    2017-01-01

    Aims To investigate the role of endoscopic sphincterotomy (ES) with endoscopic biliary drainage (EBD) in acute severe obstructive cholangitis management by performing a meta-analysis of controlled trials. Method We searched PubMed and Embase for controlled studies that compared endoscopic drainage with ES versus Non-ES in acute obstructive cholangitis. Two reviewers selected the studies and extracted the data. Disagreement was addressed by a third reviewer. Heterogeneity of the studies was analyzed by Cochran’s Q statistics. A Mantel–Haenszel risk ratio was calculated utilizing a random effects model. Results Four controlled studies met our inclusion criteria with 392 participants (201 ES, 191 Non-ES). The outcomes were drainage insertion success rate, drainage effectiveness, post drainage pancreatitis, bleeding, procedure duration, perforation, cholecystitis, and 30-day mortality. Drainage insertion success rate was identical in both groups (RR: 1.00, 95 %CI% 0.96 – 1.04). Effective drainage was not significantly different (RR: 1.11, 95 %CI 0.73 – 1.7). There was no significant difference in the incidence of pancreatitis post EBD between the ES and Non-ES groups at 3 % and 4 %, respectively (RR: 0.73, 95 %CI 0.24 – 2.27). However, there was a significant increase in post EBD bleeding with ES compared to Non-ES (RR: 8.58, 95 %CI 2.03 – 36.34). Thirty-day mortality was similar between ES and Non-ES groups at 0.7 % and 1 %, respectively (RR: 0.5, 95 %CI 0.05 – 5.28). Conclusion Our findings show that EBD without ES is an effective drainage technique and carries less risk for post procedure bleeding. Patients who are critically ill and have coagulopathy should be spared from undergoing ES in the acute phase. PMID:28229129

  20. Developing evidence-based dentistry skills: how to interpret randomized clinical trials and systematic reviews.

    Science.gov (United States)

    Kiriakou, Juliana; Pandis, Nikolaos; Madianos, Phoebus; Polychronopoulou, Argy

    2014-10-30

    Decision-making based on reliable evidence is more likely to lead to effective and efficient treatments. Evidence-based dentistry was developed, similarly to evidence-based medicine, to help clinicians apply current and valid research findings into their own clinical practice. Interpreting and appraising the literature is fundamental and involves the development of evidence-based dentistry (EBD) skills. Systematic reviews (SRs) of randomized controlled trials (RCTs) are considered to be evidence of the highest level in evaluating the effectiveness of interventions. Furthermore, the assessment of the report of a RCT, as well as a SR, can lead to an estimation of how the study was designed and conducted.

  1. The challenge, access, risks, and deficits of evidence-based dentistry.

    Science.gov (United States)

    Niederman, Richard; Richards, Derek

    2010-01-01

    The ultimate goal of evidence-based health care (EBH) and evidence-based dentistry (EBD) is the improvement of health of our patients, our practices, and our families. The mechanics of balancing these in the face of overwhelming and increasing information is a challenge. With this challenge come the benefits of access to knowledge that can improve health, the legal risks for inattention, and arguments to the contrary. This conceptual introduction does not provide the truth--it provides one viewpoint. Clinicians will need to decide for themselves if and when they might (or might not) chose to embrace an evidence-based approach to healthcare improvement.

  2. Metalliferous sediment and a silica-hematite deposit within the Blanco fracture zone, Northeast Pacific

    Science.gov (United States)

    Hein, J.R.; Clague, D.A.; Koski, R.A.; Embley, R.W.; Dunham, R.E.

    2008-01-01

    A Tiburon ROV dive within the East Blanco Depression (EBD) increased the mapped extent of a known hydrothermal field by an order of magnitude. In addition, a unique opal-CT (cristobalite-tridymite)-hematite mound was discovered, and mineralized sediments and rock were collected and analyzed. Silica-hematite mounds have not previously been found on the deep ocean floor. The light-weight rock of the porous mound consists predominantly of opal-CT and hematite filaments, rods, and strands, and averages 77.8% SiO2 and 11.8% Fe2O3. The hematite and opal-CT precipitated from a low-temperature (???115?? C), strongly oxidized, silica- and iron-rich, sulfur-poor hydrothermal fluid; a bacterial mat provided the framework for precipitation. Samples collected from a volcaniclastic rock outcrop consist primarily of quartz with lesser plagioclase, smectite, pyroxene, and sulfides; SiO2 content averages 72.5%. Formation of these quartz-rich samples is best explained by cooling in an up-flow zone of silica-rich hydrothermal fluids within a low permeability system. Opal-A, opal-CT, and quartz mineralization found in different places within the EBD hydrothermal field likely reflects decreasing silica saturation and increasing temperature of the mineralizing fluid with increasing silica crystallinity. Six push cores recovered gravel, coarse sand, and mud mineralized variously by Fe or Mn oxides, silica, and sulfides. Total rare-earth element concentrations are low for both the rock and push core samples. Ce and Eu anomalies reflect high and low temperature hydrothermal components and detrital phases. A remarkable variety of types of mineralization occur within the EBD field, yet a consistent suite of elements is enriched (relative to basalt and unmineralized cores) in all samples analyzed: Ag, Au, S, Mo, Hg, As, Sb, Sr, and U; most samples are also enriched in Cu, Pb, Cd, and Zn. On the basis of these element enrichments, the EBD hydrothermal field might best be described as a base

  3. Comparison of two stochastic techniques for reliable urban runoff prediction by modeling systematic errors

    DEFF Research Database (Denmark)

    Del Giudice, Dario; Löwe, Roland; Madsen, Henrik;

    2015-01-01

    provide probabilistic predictions of wastewater discharge in a similarly reliable way, both for periods ranging from a few hours up to more than 1 week ahead of time. The EBD produces more accurate predictions on long horizons but relies on computationally heavy MCMC routines for parameter inferences......In urban rainfall-runoff, commonly applied statistical techniques for uncertainty quantification mostly ignore systematic output errors originating from simplified models and erroneous inputs. Consequently, the resulting predictive uncertainty is often unreliable. Our objective is to present two...

  4. Implementing healthcare excellence: the vital role of the CEO in evidence-based design.

    Science.gov (United States)

    Zimring, Craig; Augenbroe, Godfried L; Malone, Eileen B; Sadler, Blair L

    2008-01-01

    This paper explores the role of the chief executive officer (CEO) in evidence-based design (EBD), discussing the internal and external challenges that a CEO faces, such as demands for increased quality, safety, patient-and-family-centeredness, increased revenue, and reduced cost. Based on a series of interviews and case studies and the experience of the authors as researchers, consultants, and CEOs, this paper provides a model for EBD and recommends actions that a CEO can undertake to create an effective project over the life cycle of a building. TOPICAL HEADINGS: Evidence-Based Design: A Performance-Based Approach to Achieving Key Goals; Key Approaches to Executing Evidence-Based Design; Overcoming Barriers to Innovation: The CEO's Vital Role in Implementing Evidence-Based Design The CEO bears special responsibility for successful facility project implementation. Only the CEO possesses the responsibility and authority to articulate the strategy, vision, goals, and resource constraints that frame every project. With the support of their boards, CEOs set the stage for the transformation of an organization's culture and fuel clinical and business process reengineering by encouraging and, if necessary, forcing collaboration between the strong disciplinary and departmental divisions found in healthcare systems.

  5. An experimental and theoretical investigation into the ``worm-hole'' effect

    Science.gov (United States)

    Zhao, Liang; Su, Jiancang; Zhang, Xibo; Pan, Yafeng; Wang, Limin; Fang, Jinpeng; Sun, Xu; Li, Rui; Zeng, Bo; Cheng, Jie

    2013-08-01

    On a nanosecond time scale, solid insulators abnormally fail in bulk rather than on surface, which is termed as the "worm-hole" effect. By using a generator with adjustable output pulse width and dozens of organic glass (PMMA) and polystyrene (PS) samples, experiments to verify this effect are conducted. The results show that under short pulses of 10 ns, all the samples fail due to bulk breakdown, whereas when the pulse width is tuned to a long pulse of 7 μs, the samples fail as a result of surface flashover. The experimental results are interpreted by analyzing the conditions for the bulk breakdown and the surface flashover. It is found that under short pulses, the flashover threshold would be as high as the bulk breakdown strength (EBD) and the flashover time delay (td) would be longer than the pulse width (τ), both of which make the dielectrics' cumulative breakdown occur easily; whereas under long pulses, that Ef is much lower than EBD and td is smaller than τ is advantageous to the occurrence of the surface flashover. In addition, a general principle on solid insulation design under short pulse condition is proposed based on the experimental results and the theoretical analysis.

  6. Fundamentals in Biostatistics for Investigation in Pediatric Dentistry: Part II -Biostatistical Methods.

    Science.gov (United States)

    Pozos-Guillén, Amaury; Ruiz-Rodríguez, Socorro; Garrocho-Rangel, Arturo

    The main purpose of the second part of this series was to provide the reader with some basic aspects of the most common biostatistical methods employed in health sciences, in order to better understand the validity, significance and reliability of the results from any article on Pediatric Dentistry. Currently, as mentioned in the first paper, Pediatric Dentists need basic biostatistical knowledge to be able to apply it when critically appraise a dental article during the Evidence-based Dentistry (EBD) process, or when participating in the development of a clinical study with dental pediatric patients. The EBD process provides a systematic approach of collecting, review and analyze current and relevant published evidence about oral health care in order to answer a particular clinical question; then this evidence should be applied in everyday practice. This second report describes the most commonly used statistical methods for analyzing and interpret collected data, and the methodological criteria to be considered when choosing the most appropriate tests for a specific study. These are available to Pediatric Dentistry practicants interested in reading or designing original clinical or epidemiological studies.

  7. Intraparenchymal ultrasound application and improved distribution of infusate with convection-enhanced delivery in rodent and nonhuman primate brain.

    Science.gov (United States)

    Mano, Yui; Saito, Ryuta; Haga, Yoichi; Matsunaga, Tadao; Zhang, Rong; Chonan, Masashi; Haryu, Shinya; Shoji, Takuhiro; Sato, Aya; Sonoda, Yukihiko; Tsuruoka, Noriko; Nishiyachi, Keisuke; Sumiyoshi, Akira; Nonaka, Hiroi; Kawashima, Ryuta; Tominaga, Teiji

    2016-05-01

    OBJECT Convection-enhanced delivery (CED) is an effective drug delivery method that delivers high concentrations of drugs directly into the targeted lesion beyond the blood-brain barrier. However, the drug distribution attained using CED has not satisfactorily covered the entire targeted lesion in tumors such as glioma. Recently, the efficacy of ultrasound assistance was reported for various drug delivery applications. The authors developed a new ultrasound-facilitated drug delivery (UFD) system that enables the application of ultrasound at the infusion site. The purpose of this study was to demonstrate the efficacy of the UFD system and to examine effective ultrasound profiles. METHODS The authors fabricated a steel bar-based device that generates ultrasound and enables infusion of the aqueous drug from one end of the bar. The volume of distribution (Vd) after infusion of 10 ml of 2% Evans blue dye (EBD) into rodent brain was tested with different frequencies and applied voltages: 252 kHz/30 V; 252 kHz/60 V; 524 kHz/13 V; 524 kHz/30 V; and 524 kHz/60 V. In addition, infusion of 5 mM gadopentetate dimeglumine (Gd-DTPA) was tested with 260 kHz/60 V, the distribution of which was evaluated using a 7-T MRI unit. In a nonhuman primate (Macaca fascicularis) study, 300 μl of 1 mM Gd-DTPA/EBD was infused. The final distribution was evaluated using MRI. Two-sample comparisons were made by Student t-test, and 1-way ANOVA was used for multiple comparisons. Significance was set at p < 0.05. RESULTS After infusion of 10 μl of EBD into the rat brain using the UFD system, the Vds of EBD in the UFD groups were significantly larger than those of the control group. When a frequency of 252 kHz was applied, the Vd of the group in which 60 V was applied was significantly larger than that of the group in which 30 V was used. When a frequency of 524 kHz was applied, the Vd tended to increase with application of a higher voltage; however, the differences were not significant (1-way

  8. Influence of blood-brain barrier permeability on O-(2-{sup 18}F-fluoroethyl)-L-tyrosine uptake in rat gliomas

    Energy Technology Data Exchange (ETDEWEB)

    Stegmayr, Carina; Bandelow, Ulrike; Oliveira, Dennis; Lohmann, Philipp; Willuweit, Antje; Galldiks, Norbert; Luebke, Joachim H.R. [Institute of Neuroscience and Medicine, Forschungszentrum Juelich, Juelich (Germany); Filss, Christian; Ermert, Johannes; Langen, Karl-Josef [Institute of Neuroscience and Medicine, Forschungszentrum Juelich, Juelich (Germany); RWTH/University Hospital Aachen, Department of Nuclear Medicine and Neurology, Aachen (Germany); Shah, N. Jon [Institute of Neuroscience and Medicine, Forschungszentrum Juelich, Juelich (Germany); RWTH/University Hospital Aachen, Department of Nuclear Medicine and Neurology, Aachen (Germany); Juelich-Aachen Research Alliance (JARA) - Section JARA-Brain, Aachen (Germany)

    2017-03-15

    O-(2-{sup 18}F-fluoroethyl)-L-tyrosine ({sup 18}F-FET) is an established tracer for the diagnosis of brain tumors with PET. This study investigates the influence of blood-brain barrier (BBB) permeability on {sup 18}F-FET uptake in two rat glioma models and one human xenograft model. F98 glioma, 9L gliosarcoma or human U87 glioblastoma cells were implanted into the striatum of 56 Fischer or RNU rats. Thereafter, animals were divided into a control group and a group receiving injections of the glucocorticoid dexamethasone (Dex). After 12-13 days of tumor growth animals received injection of Evans blue dye (EBD) to visualize BBB disturbance and underwent {sup 18}F-FET PET followed by autoradiography. Time activity curves, standardized uptake values (SUV) and Tumor-to-brain ratios (TBR) of {sup 18}F-FET uptake [18-61 min post injection (p.i.)] were evaluated using a volume-of-Interest (VOI) analysis. BBB disturbance was quantitatively evaluated by EBD fluorescence. The membrane gaps of blood vessel endothelial tight junctions were measured using electron microscopy to visualize ultrastructural BBB alterations in one untreated and one Dex treated F98 glioma. Data were analyzed by two-way ANOVAs. In Dex treated animals EBD extravasation was significantly reduced in 9L (P < 0.001) and U87 (P = 0.008) models and showed a trend in F98 models (P = 0.053). In contrast, no significant differences of {sup 18}F-FET uptake were observed between Dex treated animals and control group except a decrease of the TBR in the 9L tumor model in PET (P < 0.01). Ultrastructural evaluation of tumor blood vessel endothelia revealed significant reduction of the cleft diameter between endothelial cells after Dex treatment in F98 model (P = 0.010). Despite a considerable reduction of BBB permeability in rat gliomas after Dex treatment, no relevant changes of {sup 18}F-FET uptake were noted in this experimental study. Thus, {sup 18}F-FET uptake in gliomas appears to be widely independent of the

  9. (32)P-postlabelling analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro.

    Science.gov (United States)

    Zhao, C; Koskinen, M; Hemminki, K

    2000-01-01

    Butadiene monoepoxide (BMO), epoxybutanediol (EBD) and diepoxybutane (DEB) are reactive metabolites of 1,3-butadiene (BD), an important industrial chemical classified as a probable human carcinogen. The covalent interactions of these metabolites with DNA lead to the formation of DNA adducts which may induce mutations or other types of DNA damage, resulting in tumour formation. In the present study, two pairs of diastereomeric N-1-BMO-adenine adducts were identified in the reaction of BMO with 2´-deoxyadenosine-5´-monophosphate (5´-dAMP). The major products formed by reacting EBD with 2´-deoxyguanosine-5´-monophosphate (5´-dGMP) were characterized as diastereomeric N-7-(2´,3´,4´-trihydroxybut-1´-yl)-5´-dGMP by UV and electrospray mass spectrometry. The formation of N-7-BMO-guanine adducts (1´-carbon, 60; 2´carbon, 54/10(4) nucleotides) in BMO-treated DNA was about four times higher than that of N-1-BMO-adenine adducts (1´-carbon, 20; 2´-carbon, 8.7/10(4) nucleotides). However, the recovery of N-1-BMO-adenine adducts in DNA (45 ± 5%) was two times higher than that of N-7-guanine adducts (20 ± 4%) by 32P-postlabelling analysis. Using the 32P-postlabelling/ HPLC assay, N-1-BMO-adenine, N-7-BMO-guanine and N-7-EBDguanine adducts were detected in BMO- or DEB-treated DNA and in liver DNA of rats exposed to BD by inhalation. The amount of N-7-EBD-guanine adducts (11/10(8) nucleotides) in rat liver was about three-fold higher than N-7-BMO-guanine adducts (4.0/10(8) nucleotides). The novel finding of N-1-BMO-adenine adducts formed in vivo may contribute to the understanding of the mechanisms of BD carcinogenic action.

  10. Synthesis and Tribological Studies of Branched Alcohol Derived Epoxidized Biodiesel

    Directory of Open Access Journals (Sweden)

    Qinggong Ren

    2015-09-01

    Full Text Available The optimization and kinetics of the ring-opening reaction of an epoxidized biodiesel (epoxidized rapeseed oil methyl ester (EBD with 2-ethyl hexanol (2-EH were studied. The determined optimum conditions were 4:1 2-EH/oil molar ratio, 90 °C, 18 h, and 7 wt % of Amberlyst D001 (dry catalyst; the product’s oxirane oxygen content was 0.081% with 38.32 mm2/s viscosity at 40 °C. The catalyst retained its high catalytic power after recycling five times. Furthermore, the determined non-catalyzed activation energy was 76 kJ·mol−1 and 54 kJ·mol−1 with the D001 resin catalyst. The product’s chemical structure was investigated through FT-IR and 1H NMR. The viscosity, flash point, pour point, and anti-wear properties of the product were improved compared with those of epoxidized biodiesel.

  11. Designing for 'meaningful' patient experience using Xperience-based designing (XbD): A new twist on a familiar approach

    DEFF Research Database (Denmark)

    Coxon, Ian Robert

    2013-01-01

    . In this paper we present ways to address this gap with a number of new twists on established Experience based Design practices (EbD) that have gained popularity in the UK and other parts of the world (NHS, 2013; Cain, 1998). At the Experience-based Designing Centre (XbDC) we are currently working within...... the larger Danish the Patient@Home research and development project. We base our design perspective on deep phenomenal understanding of patient experience beyond what is said and immediately observed, working only with the meaning level in data. We utilise immersive embodiments (always with an edge...... to practitioners who value the patient experience as an important aspect of designing-4-health in terms of products, services and systems...

  12. [Chronic hepatitis non-A, non-B hepatitis: a clinical and morphologic study].

    Science.gov (United States)

    da Silva, L C; Coêlho, M E; Pessôa, M G; Carrilho, F J; Cançado, E L; Muszkat, R M; da Fonseca, L E; Antonelli, R; Alves, V A; Gayotto, L C

    1989-01-01

    Few data on chronic non-A, non-B hepatitis (NANB-CH) have been published so far in our country. We have studied 85 patients classified into four groups: I. post-transfusional (PT), 35 patients (41.2%); II. risk group (GR), including health professionals and drug addicts, 11 (12.9%); III. sporadic with a well defined beginning (EBD), 19 (22.4%) and IV. sporadic with ill-defined beginning (END), 20 (23.5%). The mean age in group I was significantly higher than in groups II and III. A polyphasic pattern of serum aminotransferases and severe histological forms were observed in all groups. It is concluded that the way of infection has probably no prognostic importance.

  13. AKTIVITAS ANTIOKSIDAN EKSTRAK BIJI DUWET (Syzygium cumini Linn. PADA PEROKSIDASI LIPIDA SECARA IN VITRO

    Directory of Open Access Journals (Sweden)

    Rohadi Rohadi

    2016-04-01

    Full Text Available All parts of Syzygium cumini Linn. (duwet were widely used for medicinal plant in the treatment of various deseases. The seed extract was used to lower blood glucose. Cumini's seed had higher phenolic fractions than others. It were prepared by extracted of duwet seed "Genthong" varieties, using various extractants such as 85% ethyl acetate, 50% methanol and 50% ethanol. Duwet seed extract collected then was determined of phenolics compound and antioxidant activity assayed by measuring 2,2-diphenyl-1-picrylhydrazylradical (DPPH scavenging activity, reducing Ferric ion (Fe3+ power and inhibition of linoleic acid oxidation. The objective was to select one of the extractant which gave highest yield and polyphenolic content and its stronger antioxidant activity. Extractant 50% methanol gave highest the extract yields was 16.29 % (db. and phenolics compounds of extract was composed: total phenolic 45.99±0.25 g-GAE/100 g-extract; total flavonoid 2.28±0.07 g-QE/100 g-extract and total tannin 26.9±0.07 g-TAE/100 g-extract. All of extract exhibited strong on behalf of RSA-DPPH assay 87-95% (100  g-mL-l and reducing power, nevertheless in inhibition of linoleic acid oxidation was moderate 49-55% (400  g-mL-l. Keywords: Syzygium cumini Linn, seed, antioxidant, extraction   ABSTRAK Tanaman duwet (Syzygium cumini Linn. pada semua kompartemennya dimanfaatkan masyarakat untuk pengobatan suatu penyakit. Ekstrak bijinya dimanfaatkan untuk penurun gula darah. Bijinya merupakan bagian tanaman yang kaya senyawa polifenol. Fraksi kaya senyawa fenolik dipreparasi dengan mengekstraksi biji duwet varietas "Genthong", dengan tiga jenis ekstraktan; etil acetat 85%, metanol 50% dan etanol 50%. Ekstrak biji duwet (EBD yang diperoleh dianalisis kelompok senyawa fenolik dan aktivitas antioksidan menggunakan metode uji penangkapan radikal DPPH (2,2-diphenil 1-picrylhydrazyl, uji reduksi ion Feri (ferric reduction antioxidant power-FRAP dan uji penghambatan peroksidasi

  14. [Toxic megacolon presenting as Crohn's disease].

    Science.gov (United States)

    Sánchez Yubero, S; López Gil, A; Pérez Rojo, J A; Kessler Saiz, P

    1999-11-01

    We introduce a young patient, without history of inflammatory bowel disease (I.B.D.) who started with an acute gastroenteritis, which in the following days progressed to a toxic megacolon. The patient had come to hospital with nausea, vomiting, fever and liquid, explosive diarrhoea without pathologic products. There was no clinical remission with astringent diet, hydroelectrolitic reposition and antidiarrheic opiates. The patient was admitted in hospital when he had blood in the diarrhoea. This progressed to a toxic megacolon in three days and the patient had to be operated on urgently. The surgeons found perforations in the colon and the pathologists diagnosed Crohn disease. Even without previous E.B.D. history we reached the diagnosis from the clinical and analytical data and the plain abdominal radiology. It was impossible to confirm the diagnosis with a colonoscopy because of the high risk of perforation. In cases like this, early surgery may save the life of the patient.

  15. Biliary tuberculosis causing cicatricial stenosis after oral anti-tuberculosis therapy

    Institute of Scientific and Technical Information of China (English)

    Tomohisa Iwai; Mitsuhiro Kida; Yoshiki Kida; Nobuaki Shikama; Akitaka Shibuya; Katsunori Saigenji

    2006-01-01

    A 36-year-old Philippine woman presented with dark urine and yellow sclera. Endoscopic retrograde cholangiopancreatography (ERCP) confirmed dilatation of the intrahepatic bile ducts and also showed an irregular stricture of the common hepatic duct at the liver hilum. Histological examination of biopsies from the bile duct revealed epithelioid cell granulomas and caseous necrosis. Tubercle bacilli were then detected on polymerase chain reaction (PCR) testing of the bile, giving the diagnosis of biliary tuberculosis. Although microbiological cure was confirmed, the patient developed cicatricial stenosis of the hepatic duct. She underwent repeated treatments with endoscopic biliary drainage (EBD) tubes and percutaneous transhepatic biliary drainage (PTBD) tubes, and the stenosis was corrected after 6 years. We present a case of tuberculous biliary stricture, a condition that requires careful differentiation from the more common malignancies and needs long-term follow-up due to the risk of posttreatment cicatricial stenosis, although it is rare.

  16. LOS MODELOS DE ADQUISICIÓN Y ENSEÑANZA EN UNA SEGUNDA LENGUA, Y LA HIPÓTESIS DEL FILTRO AFECTIVO DE KRASHEN

    Directory of Open Access Journals (Sweden)

    Hamdan Al Shehri

    2012-05-01

    There has been considerable research on some factors influencing academic performance of students based on emotional and behavioural disabilities/disorders (EBD regarding academic achievement. Stephen Krashen tackles this problem from his theory of second language acquisition, called the monitor hypothesis, where he considers up to nine different hypotheses, among which, is the affective filter hypothesis. This academic paper proposes a study of this hypothesis considering the impediment to learning caused by negative emotional responses to one’s environment, in two different sections; approaches and methods in language teaching by one hand, and theories of acquisition and learning in second language by another, whereupon we suggest some activities, which seem to assuage these effects.

  17. The American Dental Association's Center for Evidence-Based Dentistry: a critical resource for 21st century dental practice.

    Science.gov (United States)

    Frantsve-Hawley, Julie; Jeske, Arthur

    2011-02-01

    Through its website (http:// www.ada.org/prof/resources/ebd/index.asp), the American Dental Association's Center for Evidence-Based Dentistry offers dental health professionals access to systematic reviews of oral health-related research findings, as well as Clinical Recommendations, which summarize large bodies of scientific evidence in the form of practice recommendations, e.g., the use of professionally-applied topical fluoride and pit-and-fissure sealants. Another feature of the site of great practical importance to the practicing dentist is the Critical Summary, which is a concise review of an individual systematic review's methodology and findings, as well as the importance and context of the outcomes, and the strengths and weaknesses of the systematic review and its implications for dental practice.

  18. 应用循证牙医学提高决策合理性

    Institute of Scientific and Technical Information of China (English)

    杨涛; 杨逸芬; 苏剑生

    2003-01-01

    @@ 1967年,由加拿大麦克玛斯大学的David Sackett教授首先提出循证医学(evidence based medicine,EBM)的概念,经历几十年的反复验证和不断完善,其科学性和有效性得到国内外临床医师的公认,并迅速渗透到医学领域的各个分支学科.1990年,在罗彻斯特举行的"第21次国际修复学专题讨论会"上,与会学者一致认为修复学和口腔医学文献需要根本性提高,这次会议促进了循证牙医学(evidence based dentistry,EBD)的进程.

  19. Why be an evidence-based dentistry champion?

    Science.gov (United States)

    Clarkson, Jan E; Bonetti, Debbie

    2009-09-01

    Evidence-based dentistry champions are committed to improving the quality, effectiveness, and appropriateness of dental care through the application of evidence-based principles and tools. They share knowledge and skills to promote evidence-based dentistry (EBD) in practice, guiding colleagues, patients and policy makers in the application of critical thinking skills and evidence-based decision-making. Being an evidence-based champion requires furthering an understanding of the full process and the challenges of evidence based dentistry, including the development of an evidence base, evidence synthesis and summary, the creation of best practice guidelines, as well as evidence implementation. Efforts to improve the quality, effectiveness, and appropriateness of dental care need to occur at, and be coordinated across, multiple levels of dentistry, including the patient, clinician, team, organization, and policy.

  20. American Dental Association's Resources to Support Evidence-Based Dentistry.

    Science.gov (United States)

    Aravamudhan, K; Frantsve-Hawley, Julie

    2009-09-01

    Time and access have often been cited as barriers to implementing Evidence-Based Dentistry (EBD). This paper describes a new web-based resource launched by the American Dental Association to enable practitioners to incorporate evidence into treatment planning. The website offers a database of systematic reviews, critical summaries of systematic reviews, evidence-based clinical recommendations and links to external resources to enable practitioners to access evidence at the point of care. In addition the site offers an online space for clinicians to suggest clinical scenarios where evidence is lacking. This could potentially be a source of topics to drive future research. With the explosion in the use of information technology within a dental office, this web-site will serve as the one-stop resource for credible scientific information for practitioners.

  1. Designing for 'meaningful' patient experience using Xperience-based designing (XbD): A new twist on a familiar approach

    DEFF Research Database (Denmark)

    Coxon, Ian Robert

    2013-01-01

    requires a heavy reliance on welfare technology solutions currently being developed that promote outpatient self-management and home-care. In the rush to accomplish these admirable goals the patient experience of existing and proposed services and products in most cases, has been largely overlooked....... In this paper we present ways to address this gap with a number of new twists on established Experience based Design practices (EbD) that have gained popularity in the UK and other parts of the world (NHS, 2013; Cain, 1998). At the Experience-based Designing Centre (XbDC) we are currently working within...... (experiential knowledge exchange) with various stakeholders (patients, therapists and technology manufacturers) so as to begin designing activities such as co-creation workshops. Applying such methods has resulted in new and useful outcomes in projects investigating patient experiences such as disability...

  2. [Social network analysis and eating disorders: a study concerning blogs].

    Science.gov (United States)

    Bastianelli, Alessia; Spoto, Andrea; Vidotto, Giulio

    2011-01-01

    This study is aimed at analyzing the structure of relations among blogs referring to Eating Disorders (ED). Through the use Of Social Network Analysis (SNA) we investigated both the groups and their structure in order to study the social processes within the network. A formal analysis of the ED blogs' characteristics has been carried out. This analysis provided us with information about network Centrality and Cohesion parameters. Results allow us to highlight the most relevant blogs in the network. Even if the extremely variable nature of the blogs does not allow to have a precise picture of the blogosphere referring to ED, this first attempt to apply SNA in this field allowed us to suggest interesting remarks about EBD both from the research and from the social perspective.

  3. Smart Textiles in Humanistic Hospital Design

    DEFF Research Database (Denmark)

    Mogensen, Jeppe; Fisker, Anna Marie; Poulsen, Søren Bolvig

    2014-01-01

    of some of the stakeholders involved in the design process? Relating to the Danish scene of hospital design, we introduce the research project “Smart Textiles in Future Hospitals”, stating the overall hypothesis that textiles in hospital interiors possess an unexploited architectural potential in relation......Hospitalised patients’ healing process, supported by stimulating architecture. In this regard, we address focus on the potential influence of the design principle, discussing how healing architecture may contribute in making the future hospital institutions more responsive to human needs. The main...... purpose of this paper is thus to present a review of healing architecture, by considering some of the challenges in the operational use of the design principle. Associated with the methodology of evidence-based design (EBD), we in this regard question, if these challenges derive from conflicting paradigms...

  4. Fundamentals in Biostatistics for Research in Pediatric Dentistry: Part I - Basic Concepts.

    Science.gov (United States)

    Garrocho-Rangel, J A; Ruiz-Rodríguez, M S; Pozos-Guillén, A J

    The purpose of this report was to provide the reader with some basic concepts in order to better understand the significance and reliability of the results of any article on Pediatric Dentistry. Currently, Pediatric Dentists need the best evidence available in the literature on which to base their diagnoses and treatment decisions for the children's oral care. Basic understanding of Biostatistics plays an important role during the entire Evidence-Based Dentistry (EBD) process. This report describes Biostatistics fundamentals in order to introduce the basic concepts used in statistics, such as summary measures, estimation, hypothesis testing, effect size, level of significance, p value, confidence intervals, etc., which are available to Pediatric Dentists interested in reading or designing original clinical or epidemiological studies.

  5. Blood immunological parameters upon hypoxic-ischemic injuries of central nervous system in newborns and infants

    Directory of Open Access Journals (Sweden)

    Gulomjan Khalimbetov

    2012-05-01

    Full Text Available The paper studies interrelation between immune system condition and circulating concentrations of neuropeptides and neuron-specific enolase (NSE upon perinatal pathology in newborns and infants. Reactivity of cytokine and interleukin links of immune systems was found varying in newborns and infants with CNS hypoxic-ischemic pathology, accompanied by psychomotor retardation, a psycho-speech disorder, emotional and behavioral disorders (EBD and paroxysmal syndrome. At admission irrespectively of a syndrome type in the patients with CNS hypoxic-ischemic pathology, as compared with the patients in the control group, circulating TNF-α and IL-1 were found increased by 3.4-4.1 and 6.4-7.9 times, respectively. Release of S100 protein and NSE seems to be the underlying mechanism for enhancement of synthesis and/or release of TNF-α and IL-1 into circulation of patients with CNS hypoxic-ischemic pathology.

  6. Research in dentistry: Question, search and studies design.

    Directory of Open Access Journals (Sweden)

    Pedro Aravena

    2012-12-01

    Full Text Available Evidence-based dentistry (EBD concept has caused great impact and interest in the field of dentistry. For its development is important to use research protocols and study designs according to the research problem. The aim of this review is to present basic aspects for the start of a quantitative research in dentistry.It presents the topics necessary to transform a research problem to a question with clinical approach. Then, concepts about finding relevant scientific articles in the electronic databases available on the Internet. It also presents observational and experimental research designs, their classification and topics for your choice. These elements represents simple and clear recommendations for research in dentistry.

  7. Bis-butanediol-mercapturic acid (bis-BDMA) as a urinary biomarker of metabolic activation of butadiene to its ultimate carcinogenic species.

    Science.gov (United States)

    Kotapati, Srikanth; Sangaraju, Dewakar; Esades, Amanda; Hallberg, Lance; Walker, Vernon E; Swenberg, James A; Tretyakova, Natalia Y

    2014-06-01

    Human carcinogen 1,3-butadiene (BD) undergoes metabolic activation to 3,4-epoxy-1-butene (EB), hydroxymethylvinyl ketone (HMVK), 3,4-epoxy-1,2-butanediol (EBD) and 1,2,3,4-diepoxybutane (DEB). Among these, DEB is by far the most genotoxic metabolite and is considered the ultimate carcinogenic species of BD. We have shown previously that BD-exposed laboratory mice form 8- to 10-fold more DEB-DNA adducts than rats exposed at the same conditions, which may be responsible for the enhanced sensitivity of mice to BD-mediated cancer. In the present study, we have identified 1,4-bis-(N-acetyl-L-cystein-S-yl)butane-2,3-diol (bis-BDMA) as a novel DEB-specific urinary biomarker. Isotope dilution high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry was employed to quantify bis-BDMA and three other BD-mercapturic acids, 2-(N-acetyl-L-cystein-S-yl)-1-hydroxybut-3-ene/1-(N-acetyl-L-cystein-S-yl)-2-hydroxy-but-3-ene (MHBMA, from EB), 4-(N-acetyl-L-cystein-S-yl)-1,2-dihydroxybutane (DHBMA, from HMVK) and 4-(N-acetyl-L-cystein-S-yl)-1,2,3-trihydroxybutane (THBMA, from EBD), in urine of confirmed smokers, occupationally exposed workers and BD-exposed laboratory rats. Bis-BDMA was formed in a dose-dependent manner in urine of rats exposed to 0-200 p.p.m. BD by inhalation, although it was a minor metabolite (1%) as compared with DHBMA (47%) and THBMA (37%). In humans, DHBMA was the most abundant BD-mercapturic acid excreted (93%), followed by THBMA (5%) and MHBMA (2%), whereas no bis-BDMA was detected. These results reveal significant differences in metabolism of BD between rats and humans.

  8. Methods for Assessment of Burden of Climate Change-Related Diseases%气候变化相关疾病负担的评估方法

    Institute of Scientific and Technical Information of China (English)

    王金娜; 姜宝法

    2012-01-01

    Climate change has had significant impact on human health,with increased burden of disease,so,researches on impacts of climate change to population burden of disease appears to be particularly important.Most of the researches used the method of environmental burden of disease (EBD),which included the indicator of the disability adjusted life years (DALYs) and the application of comparative risk assessment methods (CRA).This paper reviewed the relevant researches both at home and abroad to find the methods for estimating aggregate disease burdens attributable to climate change.Three steps should be included in the study: (1) to calculate the DALYs of the baseline year,(2) to get the population attributable fraction (PAF) by the application of CRA methods.(3) attributable burden=PAFxtotal burden.%气候变化已经明显影响到人类的健康,造成疾病负担的加重,因此,开展气候变化对人群疾病负担影响的研究显得尤为重要.目前气候变化疾病负担的评估主要应用了环境疾病负担(EBD)的评估方法,主要为伤残调整寿命年(DALY)的计算和风险评估模型(CRA)的应用.该文综述了国内外气候变化疾病负担评估的基本方法,通过计算基准年的DALY值、应用CRA模型来计算归因分值(PAF)、总的疾病负担与归因分值的乘积等一系列步骤,最终得出归因于气候变化的疾病负担.

  9. Evidence-based dentistry and clinical implementation by third-year dental students.

    Science.gov (United States)

    Teich, Sorin T; Demko, Catherine A; Lang, Lisa A

    2013-10-01

    Over the last two decades, the concept of evidence-based medicine (EBM) has become the standard of medical care. Defined by Sackett et al. as "the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients," EBM recognizes that the practitioner should combine individual clinical expertise with the best available external evidence for optimal care. Consideration of the patient's needs and preferences is also an integral component of the clinical application. Dental educators have to account for the fact that not all dental treatment outcomes have been researched with randomized clinical trials. Dogmas in dentistry still exist regarding restorative treatments and methods taught to next generations of practitioners, while limited evidence is available. The purpose of this study was to determine how third-year dental students at one U.S. dental school select articles to provide supportive evidence related to treatment planning. The results show that knowledge provided in a three-week course in evidence-based dentistry (EBD) for first-year dental students was not efficiently applied when the students reached their third year. A significant percentage of the students perceived the use of literature as not beneficial for sustaining clinical aspects of a treatment plan, and they did not use appropriate tools to access best available resources. As a result of these findings, the article proposes incorporation of specific learning objectives related to EBD principles throughout the curriculum and a simplified method to search for best available evidence that has the advantage of not requiring knowledge and training in rigorous formulation of clinical questions.

  10. Effects of the treatment with different fluids on alveolar epithelium barrier in rats with acute lung injury%不同液体治疗对急性肺损伤大鼠肺泡上皮细胞屏障功能的影响

    Institute of Scientific and Technical Information of China (English)

    魏洪霞; 杨毅; 邱海波; 郭涛; 赵明明; 陈秋华

    2009-01-01

    目的 观察不同液体治疗对急性肺损伤(ALI)大鼠肺泡上皮细胞屏障功能的影响.方法 ①与对照组比较,LPS组、NS组肺损伤评分明显升高(P均0.05),且后3组间比较差异也无统计学意义.②与对照组比较,LPS组、NS组肺W/D比值明显升高(P均0.05).⑤各组肺泡上皮细胞凋亡指数(AI)明显高于对照组(P均0.05).结论 胶体液较NS更能改善ALI大鼠肺泡上皮通透性,保护上皮细胞屏障功能.%Objective To observe the effects of different fluids on alveolar epithelium barrier in rats with acute lung injury (ALI). Methods Thirty-six Sprague-Dawley (SD) rats were randomly assigned into six groups with 6 rats in each group. ALI was induced by intravenous injection of lipopolysaccharide(LPS). Rats in all treatment groups were given different fluids and sacrificed after 4 hours. Evans blue dye (EBD) was injected via the femoral vein 30 minutes before death. Tracheobronchial tree was washed with normal saline (NS) after death, and broncho-alveolar lavage fluid (BALF) was collected. Leakage of EBD from blood into BALF (alveolar epithelial permeability) and wet/dry (W/D) ratio were measured. The mRNA expression of surfactant protein-C (SP-C) was assessed by reverse transcription-polymerase chain reaction (RT-PCR). Alveolar epithelium apoptosis was detected by terminal deoxynucleotidyl transferase-mediated dUTP biotin nick end labeling (TUNEL). Lung injury was evaluated by Smith lung injury score. Results ①Lung injury scores in LPS and NS groups were significantly higher than in control group (both P0.05). No significant difference was found among the latter three groups. ②W/D ratio in LPS and NS groups were significantly higher than that in control group (both P0.05). ⑤Apoptosis index (AI) of alveolar epithelial cell in all the treatment groups were significantly higher than that in control group (all P<0.05). Compared with NS group, AI were noticeably lower in ALB and HES groups (both P<0

  11. Transcription factor-based biosensors enlightened by the analyte.

    Directory of Open Access Journals (Sweden)

    Raul eFernandez-Lopez

    2015-07-01

    Full Text Available Whole cell biosensors (WCBs have multiple applications for environmental monitoring, detecting a wide range of pollutants. WCBs depend critically on the sensitivity and specificity of the transcription factor (TF used to detect the analyte. We describe the mechanism of regulation and the structural and biochemical properties of TF families that are used, or could be used, for the development of environmental WCBs. Focusing on the chemical nature of the analyte, we review TFs that respond to aromatic compounds (XylS-AraC, XylR-NtrC and LysR, metal ions (MerR, ArsR, DtxR, Fur and NikR or antibiotics (TetR and MarR. Analyzing the structural domains involved in DNA recognition, we highlight the similitudes in the DNA binding domains (DBDs of these TF families. Opposite to DBDs, the wide range of analytes detected by TFs results in a diversity of structures at the effector binding domain (EBD. The modular architecture of TFs opens the possibility of engineering TFs with hybrid DNA and effector specificities. Yet, the lack of a crisp correlation between structural domains and specific functions makes this a challenging task.

  12. Cu passivation for integration of gap-filling ultralow-k dielectrics

    Science.gov (United States)

    Zhang, Liping; de Marneffe, Jean-Francois; Lesniewska, Alicja; Verdonck, Patrick; Heylen, Nancy; Murdoch, Gayle; Croes, Kristof; Boemmels, Juergen; Tokei, Zsolt; De Gendt, Stefan; Baklanov, Mikhail R.

    2016-12-01

    For Cu/low-k interconnects, the reversed damascene is an alternative integration approach where the metal wires are patterned first and then the spacing filled with a flowable dielectric. In this paper, the replacement of a sacrificial template by gap-filling ultralow-k dielectrics is studied, focusing on yield and transport performance ("replacement dielectric" scheme). On non-passivated copper, the low-k curing processes induce severe damage to the metal lines, leading to the degraded electrical properties. This is confirmed by chemical inspection on the blanket Cu films and morphological inspection on patterned structures. In order to avoid Cu oxidation and out-diffusion at elevated temperature, Cu passivation by plasma-enhanced chemical vapor deposition SiCN is proposed and studied in detail. The inter-metal dielectric properties of replacement low-k are evaluated by resistance-capacitance and IV measurements using a Meander-Fork structure. By tuning the passivation layer thickness and ultraviolet curing time, high electrical yield is obtained with integrated porous low-k showing promising effective k-values (keff) and breakdown voltages (Ebd), confirming the interest of this specific integration scheme.

  13. Making generic tutorials content specific: recycling evidence-based practice (EBP) tutorials for two disciplines.

    Science.gov (United States)

    Jeffery, Keven M; Maggio, Lauren; Blanchard, Mary

    2009-01-01

    Librarians at the Boston University Medical Center constructed two interactive online tutorials, "Introduction to EBM" and "Formulating a Clinical Question (PICO)," for a Family Medicine Clerkship and then quickly repurposed the existing tutorials to support an Evidence-based Dentistry course. Adobe's ColdFusion software was used to populate the tutorials with course-specific content based on the URL used to enter each tutorial, and a MySQL database was used to collect student input. Student responses were viewable immediately by course faculty on a password-protected Web site. The tutorials ensured that all students received the same baseline training and allowed librarians to tailor a subsequent library skills workshop to student tutorial answers. The tutorials were well-received by the medical and dental schools and have been added to mandatory first-year Evidence-based Medicine (EBM) and Evidence-based Dentistry (EBD) courses, meaning that every medical and dental student at BUMC will be expected to complete these tutorials.

  14. Simple Clinical Score to Predict 24-Week Survival Times in Patients with Inoperable Malignant Distal Biliary Obstruction as a Tool for Selecting Palliative Metallic or Plastic Stents.

    Science.gov (United States)

    Sripongpun, Pimsiri; Attasaranya, Siriboon; Chamroonkul, Naichaya; Sookpaisal, Theerapong; Khow-Ean, Uthai; Siripun, Aroon; Kongkamol, Chanon; Piratvisuth, Teerha; Ovartlarnporn, Bancha

    2017-01-17

    Endoscopic biliary drainage (EBD) is the mainstay treatment for inoperable malignant distal biliary obstruction (MDBO). Some authorities suggest that metallic stents are more cost-effective than plastic stents in patients with expected survival of at least 6 months. However, studies attempting to define the predictive factors for such survival times are limited. This study aims to develop a scoring system for predicting a survival time of clinical, laboratory, and imaging data were retrieved. The survival time data were retrieved from the medical records and Thailand's civil registration database. Multivariate Cox regression model coefficients were used in the development of a survival time prediction scoring system. Ninety-eight patients were included. The overall median survival was 17.6 weeks. Fifty-seven (58.1%) survived Clinical Score (SCS) was calculated from (2× liver metastasis) + (1× pancreatic cancer) - (2× ampullary cancer) - (1× cholangiocarcinoma), when 1 and 0 were used for the presence and absence of each factor, respectively. The cutoff value of the score ≥0 had a sensitivity and specificity of 0.77 and 0.63, respectively, for predicting a survival time of system from this study may be beneficial for clinicians to select the appropriate stents in endoscopic biliary drainage in inoperable MDBO patients.

  15. Measurement Of The Neutral Lambda-bottom Decaying To Positive Lambda-charm Negavtive Pion Branching Ratio

    CERN Document Server

    Le, Y

    2004-01-01

    We present a measurement of the L0b→L+ cp- branching ratio in pp¯ collisions at s = 1.96 TeV using 65 pb−1 data collected by the Collider Detector at FermiLab (CDF). The measurement starts from reconstructing two decay modes: L0b→L+ cp-,where L+c→p K- p+ B&d1;0→D+ p-,where D+→p+K- p +. We obtained 96 ± 13 L0b and 321 ± 22 B¯0 candidates from the CDF Run II Two-Track Hadronic Trigger data sample. The relative branching ratio of the two decays is then measured based on the equation: fLbfd BRLb→L +cp- BRB&d1;0 →D+p- =BRD+→Kpp BRL+ c→pKp NLbNB&d1; 0eB&d1; 0eLb . The measurement gives fLbfd BRLb→L +cp- BRB&d1;0 →D+p- =0.66±0.11stat ±0.09syst ±0.18BR . The L0b→L+ cp- branching ratio is then extracted, giving BRL0 b→L+cp- =6.6±1.2 stat.±0.9 syst.&plus...

  16. Development of analytical methods for the gas chromatographic determination of 1,2-epoxy-3-butene, 1,2:3,4-diepoxybutane, 3-butene-1,2-diol, 3,4-epoxybutane-1,2-diol and crotonaldehyde from perfusate samples of 1,3-butadiene exposed isolated mouse and rat livers

    Energy Technology Data Exchange (ETDEWEB)

    Bhowmik, S.; Schuster, A.; Filser, J.G.

    2003-07-01

    Mutagenicity and carcinogenicity of 1,3-butadiene (BD) highly probably results from epoxide metabolites as 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB) and 3,4-epoxybutane-1,2-diol (EBD). A further metabolite crotonaldehyde (CA) has also been discussed to be relevant. So far, in BD exposed rodents only EB and DEB concentrations had been quantified. However, the methods used were either not very sensitive or instrumentally expensive. Therefore, the goal of the present work was to establish simple analytical methods selective and sensitive enough to determine all of these compounds and a further secondary BD intermediate, 3-butene-1,2-diol (B-diol), in BD exposed rodent livers. The once-through perfused liver system was chosen for testing the applicability of the methods to be developed, since it enables BD exposures of this quantitatively most relevant metabolising organ near to the in-vivo situation. All the metabolites were extracted from the aqueous perfusion medium and analysed using a gas chromatograph equipped with a mass selective detector (GC/MS) in the PCI mode. (orig.)

  17. Electron beam exposure mechanisms in hydrogen silsesquioxane investigated by vibrational spectroscopy and in-situ electron beam induced desorption

    Energy Technology Data Exchange (ETDEWEB)

    Olynick, D.L.; Cord, B.; Schipotinin, A.; Ogletree, D.F.; Schuck, P.J.

    2009-11-13

    Hydrogen Silsesquioxane (HSQ) is used as a high-resolution resist with resolution down below 10nm half-pitch. This material or materials with related functionalities could have widespread impact in nanolithography and nanoscience applications if the exposure mechanism was understood and instabilities controlled. Here we have directly investigated the exposure mechanism using vibrational spectroscopy (both Raman and Fourier transform Infrared) and electron beam desorption spectrocscopy (EBDS). In the non-networked HSQ system, silicon atoms sit at the corners of a cubic structure. Each silicon is bonded to a hydrogen atom and bridges 3 oxygen atoms (formula: HSiO3/2). For the first time, we have shown, via changes in the Si-H2 peak at ~;;2200 cm -1 in the Raman spectra and the release of SiHx products in EBID, that electron-bam exposed materials crosslinks via a redistribution reaction. In addition, we observe the release of significantly more H2 than SiH2 during EBID, which is indicative of additional reaction mechanisms. Additionally, we compare the behavior of HSQ in response to both thermal and electron-beam induced reactions.

  18. Membrane Sealant Poloxamer P188 Protects Against Isoproterenol Induced Cardiomyopathy in Dystrophin Deficient Mice

    Directory of Open Access Journals (Sweden)

    Sali Arpana

    2011-05-01

    Full Text Available Abstract Background Cardiomyopathy in Duchenne muscular dystrophy (DMD is an increasing cause of death in patients. The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle. Treatment of cardiomyocyte membrane instability could help prevent cardiomyopathy. Methods Three month old female mdx mice were exposed to the β1 receptor agonist isoproterenol subcutaneously and treated with the non-ionic tri-block copolymer Poloxamer P188 (P188 (460 mg/kg/dose i.p. daily. Cardiac function was assessed using high frequency echocardiography. Tissue was evaluated with Evans Blue Dye (EBD and picrosirius red staining. Results BL10 control mice tolerated 30 mg/kg/day of isoproterenol for 4 weeks while death occurred in mdx mice at 30, 15, 10, 5 and 1 mg/kg/day within 24 hours. Mdx mice tolerated a low dose of 0.5 mg/kg/day. Isoproterenol exposed mdx mice showed significantly increased heart rates (p Conclusions This model suggests that chronic intermittent intraperitoneal P188 treatment can prevent isoproterenol induced cardiomyopathy in dystrophin deficient mdx mice.

  19. "Evidence-based dentistry in oral surgery: could we do better?".

    Science.gov (United States)

    Nocini, Pier Francesco; Verlato, Giuseppe; Frustaci, Andrea; de Gemmis, Antonio; Rigoni, Giovanni; De Santis, Daniele

    2010-07-16

    Evidence-based Dentistry (EBD), like Evidence-based Medicine (EBM), was born in order to seek the "best available research evidence" in the field of dentistry both in research and clinical routine.BUT EVIDENCE IS NOT CLEARLY MEASURABLE IN ALL FIELDS OF HEALTHCARE: in particular, while drug effect is rather independent from clinician's characteristics, the effectiveness of surgical procedures is strictly related to surgeon's expertise, which is difficult to quantify. The research problems of dentistry have a lot in common with other surgical fields, where at the moment the best therapeutic recommendations and guidelines originates from an integration of evidence-based medicine and data from consensus conferences.To cope with these problems, new instruments have been developed, aimed at standardizing clinical procedures (CAD-CAM technology) and at integrating EBM achievements with the opinions of expert clinicians (GRADE System).ONE THING WE HAVE TO REMEMBER HOWEVER: it is necessary to use the instruments developed by evidence-based medicine but is impossible to produce sound knowledge without considering clinical expertise and quality of surgical procedures simultaneously. Only in this way we will obtain an evidence-based dentistry both in dental research and clinical practice, which is up to third millennium standards.

  20. Hyperthermia of magnetic nanoparticles allows passage of sodium fluorescein and Evans blue dye across the blood-retinal barrier.

    Science.gov (United States)

    Tabatabaei, Seyed Nasrollah; Tabatabaei, Maryam Sadat; Girouard, Hélène; Martel, Sylvain

    2016-09-01

    The blood-retina barrier (BRB) is a biological barrier consisting of tightly interconnected endothelial cells inside the retinal vascular network that protects the neural tissue from harmful pathogens and neurotoxic molecules circulating in the bloodstream. Unfortunately, with regard to retinoblastoma, this barrier also prevents systemically administered therapeutics reaching the retinal tissue. In this study we introduce a novel technique to locally and transiently increase BRB permeability for drug delivery using hyperthermia of magnetic nanoparticles (MNPs). An alternating current (AC) magnetic field was used to induce hyperthermia of locally injected MNPs in the left ophthalmic artery of a rat model. To improve adherence on the surface of the endothelium, commercially available MNPs coated with human transferrin glycoproteins were used. After hyperthermia we assessed the extravasation of systemically injected sodium fluorescein (NaF) as well as Evans blue dye (EBD) into the retinal tissue. Spectrofluorometry and fluorescent microscopy image analysis show a significant increase of dye penetration in the retina where hyperthermia of MNPs was applied. Our proposed new technique can allow both small and large dye molecules to cross the BRB. While the results are preliminary and thorough evaluation of the retinal tissue following hyperthermia is necessary, this technique has the potential to be an effective mean for the treatment of various diseases such as retinoblastoma.

  1. An Evaluation of Single-Case Reading Intervention Study Quality for Students With and At Risk for Emotional and Behavioral Disorders.

    Science.gov (United States)

    McKenna, John William; Kim, Min Kyung; Shin, Mikyung; Pfannenstiel, Kathleen

    2017-04-01

    Researchers have noted the lack of research to guide reading practice for students with and at risk for emotional and behavioral disorders (EBD). Although comprehensive syntheses have identified promising practices and areas for future research, none have evaluated the rigor of studies according to quality indicators. The current study evaluated the extant single-case reading intervention research for this student population according to the What Works Clearinghouse (WWC) standards. Thirty studies met article selection criteria, 20 (66.6%) of which had at least one dependent variable that did not meet design standards. Study findings suggest a need for researchers to employ stronger designs and place a greater emphasis on investigating the effects of reading instructional practices in inclusive settings. Overall, two reading interventions were identified as potentially promising: cognitive mapping and a listening while reading accommodation. Furthermore, findings suggest that it may be advantageous to embed behavioral strategies within reading interventions. Study limitations include the exclusive use of single-case design studies and a reliance on visual analysis to determine intervention effectiveness.

  2. Alleviation of Kainic Acid-Induced Brain Barrier Dysfunction by 4-O-Methylhonokiol in In Vitro and In Vivo Models

    Directory of Open Access Journals (Sweden)

    Jin-Yi Han

    2015-01-01

    Full Text Available This experiment was designed to investigate whether 4-O-methylhonokiol (MH, a principal ingredient of Magnolia (M. officinalis bark, alleviated acute intraperitoneal (i.p. kainic acid- (KA- induced brain blood barrier dysfunction (BBBD via pathological examination and cytological analyses of the brain tissues of mice. KA (10–30 mg/kg time- and dose-dependently increased the water content of brain tissues and induced edema and encephalopathy. However, pretreatment with MH (5 and 20 mg/kg, i.p. significantly reduced the water content of the brain compared to that observed in the KA control group. Furthermore, MH significantly and dose-dependently reversed the remarkable variations in evan’s blue dye (EBD staining and malondialdehyde (MDA levels that were induced by KA (10 mg/kg, i.p.. MH also decreased the elevated seizure scores that were induced by KA (10 mg/kg, i.p. in mice in a manner similar to scavengers such as DMTU and trolox. Additionally, MH significantly scavenged intracellular ROS and Ca2+ within hippocampal cells. The tight junction seals mediated by claudin (Cld-5 were also found to be modulated by MH. MH efficiently reduced 1,1-diphenyl-2-picrylhydrazyl (DPPH (IC50, 52.4 mM and •OH with an electron spin resonance (ESR signal rate constant of 4×109 M-1·S-1, which is close to the reactivity of the vitamin E analog trolox. Taken together, these results suggest that MH may enhance radical scavenging in lipid and hydrophobic environments, which may be important for the physiological activity of the barrier.

  3. High throughput HPLC-ESI(-)-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation.

    Science.gov (United States)

    Kotapati, Srikanth; Esades, Amanda; Matter, Brock; Le, Chap; Tretyakova, Natalia

    2015-11-05

    1,3-Butadiene (BD) is an important industrial and environmental carcinogen present in cigarette smoke, automobile exhaust, and urban air. The major urinary metabolites of BD in humans are 2-(N-acetyl-L-cystein-S-yl)-1-hydroxybut-3-ene/1-(N-acetyl-L-cystein-S-yl)-2-hydroxybut-3-ene (MHBMA), 4-(N-acetyl-L-cystein-S-yl)-1,2-dihydroxybutane (DHBMA), and 4-(N-acetyl-L-cystein-S-yl)-1,2,3-trihydroxybutyl mercapturic acid (THBMA), which are formed from the electrophilic metabolites of BD, 3,4-epoxy-1-butene (EB), hydroxymethyl vinyl ketone (HMVK), and 3,4-epoxy-1,2-diol (EBD), respectively. In the present work, a sensitive high-throughput HPLC-ESI(-)-MS/MS method was developed for simultaneous quantification of MHBMA and DHBMA in small volumes of human urine (200 μl). The method employs a 96 well Oasis HLB SPE enrichment step, followed by isotope dilution HPLC-ESI(-)-MS/MS analysis on a triple quadrupole mass spectrometer. The validated method was used to quantify MHBMA and DHBMA in urine of workers from a BD monomer and styrene-butadiene rubber production facility (40 controls and 32 occupationally exposed to BD). Urinary THBMA concentrations were also determined in the same samples. The concentrations of all three BD-mercapturic acids and the metabolic ratio (MHBMA/(MHBMA+DHBMA+THBMA)) were significantly higher in the occupationally exposed group as compared to controls and correlated with BD exposure, with each other, and with BD-hemoglobin biomarkers. This improved high throughput methodology for MHBMA and DHBMA will be useful for future epidemiological studies in smokers and occupationally exposed workers.

  4. Critical review of the building downwash algorithms in AERMOD.

    Science.gov (United States)

    Petersen, Ron L; Guerra, Sergio A; Bova, Anthony S

    2017-08-01

    The only documentation on the building downwash algorithm in AERMOD (American Meteorological Society/U.S. Environmental Protection Agency Regulatory Model), referred to as PRIME (Plume Rise Model Enhancements), is found in the 2000 A&WMA journal article by Schulman, Strimaitis and Scire. Recent field and wind tunnel studies have shown that AERMOD can overpredict concentrations by factors of 2 to 8 for certain building configurations. While a wind tunnel equivalent building dimension study (EBD) can be conducted to approximately correct the overprediction bias, past field and wind tunnel studies indicate that there are notable flaws in the PRIME building downwash theory. A detailed review of the theory supported by CFD (Computational Fluid Dynamics) and wind tunnel simulations of flow over simple rectangular buildings revealed the following serious theoretical flaws: enhanced turbulence in the building wake starting at the wrong longitudinal location; constant enhanced turbulence extending up to the wake height; constant initial enhanced turbulence in the building wake (does not vary with roughness or stability); discontinuities in the streamline calculations; and no method to account for streamlined or porous structures. This paper documents theoretical and other problems in PRIME along with CFD simulations and wind tunnel observations that support these findings. Although AERMOD/PRIME may provide accurate and unbiased estimates (within a factor of 2) for some building configurations, a major review and update is needed so that accurate estimates can be obtained for other building configurations where significant overpredictions or underpredictions are common due to downwash effects. This will ensure that regulatory evaluations subject to dispersion modeling requirements can be based on an accurate model. Thus, it is imperative that the downwash theory in PRIME is corrected to improve model performance and ensure that the model better represents reality.

  5. Safety of immediate endoscopic sphincterotomy in acutesuppurative cholangitis caused by choledocholithiasis

    Institute of Scientific and Technical Information of China (English)

    2016-01-01

    AIM To examine the safety of immediate endoscopicsphincterotomy (EST) in patients with acute suppurativecholangitis (ASC) caused by choledocholithiasis, ascompared with elective EST.METHODS: Patients with ASC due to choledocholithiasiswere allocated to two groups: Those who underwent ESTimmediately and those who underwent EBD followed byEST 1 wk later because they were under anticoagulanttherapy, had a coagulopathy (international normalizedratio 〉 1.3, partial thromboplastin time greater thantwice that of control), or had a platelet count 〈 50000× 103/μL. One of four trainees [200-400 cases of endoscopicretrograde cholangiopancreatography (ERCP)]supervised by a specialist (〉 10000 cases of ERCP)performed the procedures. The success and complicationrates associated with EST in each group were examined.RESULTS: Of the 87 patients with ASC, 59 were in theimmediate EST group and 28 in the elective EST group.EST was successful in all patients in both groups. Therewere no complications associated with EST in either groupof patients, although white blood cell count, C-reactive protein, total bilirubin, and serum concentrations of liverenzymes just before EST were significantly higher in theimmediate EST group than in the elective EST group.CONCLUSION: Immediate EST can be as safe as electiveEST for patients with ASC associated with choledocholithiasisprovided they are not under anticoagulanttherapy, or donot have a coagulopathy or a platelet count 〈 50000 ×103/μL. Moreover, the procedure was safely performed by atrainee under the supervision of an experienced specialist.

  6. Structural basis for NHERF1 PDZ domain binding.

    Science.gov (United States)

    Mamonova, Tatyana; Kurnikova, Maria; Friedman, Peter A

    2012-04-10

    The Na(+)/H(+) exchange regulatory factor-1 (NHERF1) is a scaffolding protein that possesses two tandem PDZ domains and a carboxy-terminal ezrin-binding domain (EBD). The parathyroid hormone receptor (PTHR), type II sodium-dependent phosphate cotransporter (Npt2a), and β2-adrenergic receptor (β2-AR), through their respective carboxy-terminal PDZ-recognition motifs, individually interact with NHERF1 forming a complex with one of the PDZ domains. In the basal state, NHERF1 adopts a self-inhibited conformation, in which its carboxy-terminal PDZ ligand interacts with PDZ2. We applied molecular dynamics (MD) simulations to uncover the structural and biochemical basis for the binding selectivity of NHERF1 PDZ domains. PDZ1 uniquely forms several contacts not present in PDZ2 that further stabilize PDZ1 interactions with target ligands. The binding free energy (ΔG) of PDZ1 and PDZ2 with the carboxy-terminal, five-amino acid residues that form the PDZ-recognition motif of PTHR, Npt2a, and β2-AR was calculated and compared with the calculated ΔG for the self-association of NHERF1. The results suggest that the interaction of the PTHR, β2-adrenergic, and Npt2a involves competition between NHERF1 PDZ domains and the target proteins. The binding of PDZ2 with PTHR may also compete with the self-inhibited conformation of NHERF1, thereby contributing to the stabilization of an active NHERF1 conformation. © 2012 American Chemical Society

  7. Controlled fabrication of advanced functional structures on the nanoscale by means of electron beam-induced processing

    Science.gov (United States)

    Schmidt, Sebastian W.; Foucher, Johann; Penzkofer, Christian; Irmer, Bernd

    2013-05-01

    The controlled deposition of materials by means of electron beam induced processing (EBIP) is a well-established patterning method, which allows for the fabrication of nanostructures with high spatial resolution in a highly precise and flexible manner. Applications range from the production of ultrathin coatings and nanoscaled conductivity probes to super sharp atomic force microscopy (AFM) tips, to name but a few. The latter are typically deposited at the very end of silicon or silicon-nitride tips, which are fabricated with MEMS technologies. EBIP therefore provides the unique ability to converge MEMS to NEMS in a highly controllable way, and thus represents an encouraging opportunity to refine or even develop further MEMS-based features with advanced functionality and applicability. In this paper, we will present and discuss exemplary application solutions, where we successfully applied EBIP to overcome dimensional and/or functional limitations. We therefore show the fabrication stability and accuracy of "T-like-shaped" AFM tips made from high density, diamond-like carbon (HDC/DLC) for the investigation of undercut structures on the base of CDR30-EBD tips. Such aggressive CD-AFM tip dimensions are mandatory to fulfill ITRS requirements for the inspection of sub-28nm nodes, but are unattainable with state-of-art Si-based MEMS technologies today. In addition to that, we demonstrate the ability of EBIP to realize field enhancement in sensor applications and the fabrication of cold field emitters (CFE). For example: applying the EBIP approach allows for the production of CFEs, which are characterized by considerably enhanced imaging resolution compared to standard thermal field emitters and stable operation properties at room temperature without the need for periodic cathode flashing - unlike typical CFEs. Based on these examples, we outline the strong capabilities of the EBIP approach to further downscale functional structures in order to meet future demands in the

  8. Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice.

    Directory of Open Access Journals (Sweden)

    Diego C Reino

    Full Text Available Injurious non-microbial factors released from the stressed gut during shocked states contribute to the development of acute lung injury (ALI and multiple organ dysfunction syndrome (MODS. Since Toll-like receptors (TLR act as sensors of tissue injury as well as microbial invasion and TLR4 signaling occurs in both sepsis and noninfectious models of ischemia/reperfusion (I/R injury, we hypothesized that factors in the intestinal mesenteric lymph after trauma hemorrhagic shock (T/HS mediate gut-induced lung injury via TLR4 activation.The concept that factors in T/HS lymph exiting the gut recreates ALI is evidenced by our findings that the infusion of porcine lymph, collected from animals subjected to global T/HS injury, into naïve wildtype (WT mice induced lung injury. Using C3H/HeJ mice that harbor a TLR4 mutation, we found that TLR4 activation was necessary for the development of T/HS porcine lymph-induced lung injury as determined by Evan's blue dye (EBD lung permeability and myeloperoxidase (MPO levels as well as the induction of the injurious pulmonary iNOS response. TRIF and Myd88 deficiency fully and partially attenuated T/HS lymph-induced increases in lung permeability respectively. Additional studies in TLR2 deficient mice showed that TLR2 activation was not involved in the pathology of T/HS lymph-induced lung injury. Lastly, the lymph samples were devoid of bacteria, endotoxin and bacterial DNA and passage of lymph through an endotoxin removal column did not abrogate the ability of T/HS lymph to cause lung injury in naïve mice.Our findings suggest that non-microbial factors in the intestinal mesenteric lymph after T/HS are capable of recreating T/HS-induced lung injury via TLR4 activation.

  9. Treatment with GH receptor antagonist in acromegaly: effect on cardiac arrhythmias.

    Science.gov (United States)

    Auriemma, Renata S; Pivonello, Rosario; De Martino, Maria Cristina; Cudemo, Giuseppe; Grasso, Ludovica F S; Galdiero, Mariano; Perone, Ylenia; Colao, Annamaria

    2013-01-01

    To evaluate the effects of short- and long-term treatment with pegvisomant (PEG) on arrhythmias in acromegalic patients resistant to long-term, high-dose therapy with somatostatin analogs (SA). Thirteen patients entered the study. all patients started peg at initial dose of 10MG daily and then titrated to 5MG every 6 weeks on the basis of IGF1. A standard 24-H electrocardiography registration was performed in all patients at baseline and after 6 AND 18 months of PEG to evaluate: mean (HR), maximum (MHR), and minimum (mHR) heart rate; pauses number (P) and duration (PD); supraventricular episodes (SEs) number and duration (SED); and ventricular ectopic beats (EB) number and duration (EBD). Left ventricular mass (LVM) was also evaluated by standard echocardiography. A slight but not significant decrease in HR, MHR, and mHR was observed after 6-month PEG, whereas a significant decrease in HR (P=0.03), MHR (P=0.05), and mHR (P=0.05) was found after 18-month PEG compared with baseline. LVM significantly (P=0.05) correlated with MRH (r=-0.50) after short-term treatment, and with HR (r=-0.54) and mHR (r=-0.55) after long-term treatment. Long-term PEG induced the complete recovery of arrhythmias recorded at baseline in one patient and the improvement of rhythm disorders developed after 6-month therapy in another patient. The prevalence of conduction disturbances passed from 15 to 7.7% after long-term PEG. Long-term treatment with PEG reduces HR, MHR, and mHR and improves rhythm abnormalities in acromegaly.

  10. سنجش آگاهی، دانش و نگرش در زمینه دندانپزشکی مبتنی بر شواهد در دانشجویان دندانپزشکی دانشگاه علوم پزشکی مشهد

    Directory of Open Access Journals (Sweden)

    محبوبه دهقانی

    2016-03-01

    یافته ها: میزان مشارکت دانشجویان 84 درصد بود. میانگین نمره آگاهی دانشجویان 8/4±6/25 از حداکثر ممکن 50، میانگین نمره دانش خود ارزیاب 8±8/28 از حداکثر ممکن 45 و میانگین نمره نگرش 3/5±5/42 از حداکثر ممکن 60 بود. 53 درصد آنها میزان آشنایی خیلی کم/ کمی با دندانپزشکی مبتنی بر شواهد گزارش کردند. در بخش آگاهی، 46 درصد پاسخ ها، گزینه هیچ/کم بود. در قسمت دانش خود ارزیاب، یک سوم پاسخ ها، گزینه عدم فهم واژه/فهم کم بود. در حالی که در بخش نگرش، 56 درصد پاسخ ها، گزینه موافقم/کاملاً موافقم بود. نتیجه گیری: دانشجویان مورد بررسی نگرش نسبتاً خوبی در مورد دندانپزشکی مبتنی بر شواهد (EBD داشتند؛ اما آگاهی و دانش کافی در زمینه EBD را کسب نکرده بودند. ظاهراً آموزش مباحث EBD توجه بیشتری را می طلبد و شاید نیاز به اصلاح کوریکولوم آموزشی باشد.

  11. Ortodontia baseada em evidência científica: incorporando ciência na prática clínica Scientific evidence-based orthodontics: incorporating science within clinic practice

    Directory of Open Access Journals (Sweden)

    Maria Tereza Scardua Mariano

    2009-06-01

    Full Text Available O objetivo deste artigo é despertar o ortodontista e conscientizá-lo sobre a importância da tomada de decisão baseada em evidência científica no cuidado aos pacientes. Serão descritos os passos essenciais para a prática da Odontologia baseada em evidência (OBE, assim como os princípios da ciência e da pesquisa. Existem caminhos adequados para a busca da informação de qualidade, sendo esses a única garantia de encontrar artigos válidos. Na seleção de artigos científicos, o primeiro passo é definir o seu desenho, pois para cada dúvida clínica há um delineamento adequado capaz de respondê-la. Dessa maneira, questões sobre tratamento, etiologia, diagnóstico, prognóstico ou prevenção só podem ser respondidas por um artigo que tenha sido delineado para tal. O conhecimento da alocação randomizada, do mascaramento e do grupo-controle é fundamental para que possamos realizar uma leitura crítica dos artigos científicos, reconhecendo os que merecem credibilidade. Em meio a tantas publicações, precisamos definir, com segurança, o que deve ser incorporado ao nosso conhecimento e o que deve ser incorporado à prática clínica, mudando a nossa conduta. Desse modo, poderemos oferecer aos nossos pacientes opções terapêuticas mais consistentes e previsíveis.The aim of this article is to warn the orthodontist about the importance of making decision based on scientific evidence when taking care of the patients. It describes the main steps for the Dentistry practices based in evidence (EBD as well as the science and research principles. There are adequate ways for the search of quality information. While selecting the scientific articles, the first step would be defining its design, since for each question there is an adequate delineation able to answer it. Questions about treatment, etiology, diagnostic, prognostic or prevention could be answered in the article if it has been delineated for that. Understanding the meaning

  12. Anesthesia-Induced Hypothermia Attenuates Early-Phase Blood-Brain Barrier Disruption but Not Infarct Volume following Cerebral Ischemia.

    Science.gov (United States)

    Liu, Yu-Cheng; Lee, Yu-Da; Wang, Hwai-Lee; Liao, Kate Hsiurong; Chen, Kuen-Bao; Poon, Kin-Shing; Pan, Yu-Ling; Lai, Ted Weita

    2017-01-01

    Blood-brain barrier (BBB) disruption is thought to facilitate the development of cerebral infarction after a stroke. In a typical stroke model (such as the one used in this study), the early phase of BBB disruption reaches a peak 6 h post-ischemia and largely recovers after 8-24 h, whereas the late phase of BBB disruption begins 48-58 h post-ischemia. Because cerebral infarct develops within 24 h after the onset of ischemia, and several therapeutic agents have been shown to reduce the infarct volume when administered at 6 h post-ischemia, we hypothesized that attenuating BBB disruption at its peak (6 h post-ischemia) can also decrease the infarct volume measured at 24 h. We used a mouse stroke model obtained by combining 120 min of distal middle cerebral arterial occlusion (dMCAo) with ipsilateral common carotid arterial occlusion (CCAo). This model produced the most reliable BBB disruption and cerebral infarction compared to other models characterized by a shorter duration of ischemia or obtained with dMCAO or CCAo alone. The BBB permeability was measured by quantifying Evans blue dye (EBD) extravasation, as this tracer has been shown to be more sensitive for the detection of early-phase BBB disruption compared to other intravascular tracers that are more appropriate for detecting late-phase BBB disruption. We showed that a 1 h-long treatment with isoflurane-anesthesia induced marked hypothermia and attenuated the peak of BBB disruption when administered 6 h after the onset of dMCAo/CCAo-induced ischemia. We also demonstrated that the inhibitory effect of isoflurane was hypothermia-dependent because the same treatment had no effect on ischemic BBB disruption when the mouse body temperature was maintained at 37°C. Importantly, inhibiting the peak of BBB disruption by hypothermia had no effect on the volume of brain infarct 24 h post-ischemia. In conclusion, inhibiting the peak of BBB disruption is not an effective neuroprotective strategy, especially in comparison

  13. Atividade antiproliferativa dos extratos e da fração orgânica obtidos das folhas de Virola sebifera Aubl. (Myristicaceae Antiproliferative activity of extracts and fractions from Virola sebifera Aubl. leaves (Myristicaceae

    Directory of Open Access Journals (Sweden)

    Carina Denny

    2007-12-01

    Full Text Available As cascas de Virola sebifera (Myristicaceae são utilizadas por populações indígenas amazônicas em preparações alucinógenas, nas quais foram encontrados alcalóides como a dimetiltriptamina e seus derivados. Considerando a enorme importância dos alcalóides isolados de plantas na terapêutica do câncer e a presença desses compostos em espécies de Virola, o presente trabalho teve por objetivo o estudo da atividade antiproliferativa em cultura de células tumorais humanas de extratos e da fração orgânica, obtidos das folhas de Virola sebifera. O extrato bruto diclorometânico (EBD foi considerado o mais ativo, com seletividade principalmente para a linhagem de pulmão (NCI-460 - IC50: 4,46 µg/mL e para a fração orgânica (FO obtida por extração ácido-base - IC50; 6,91 µg/mL. A atividade observada possivelmente pode ser atribuída a alcalóides ou compostos nitrogenados que foram evidenciados pelo corante Dragendorff. Assim, a purificação da FO será necessária a fim de comprovar a presença de compostos nitrogenados, através de isolamento e determinação estrutural, bem como a participação desses compostos na atividade antiproliferativa observada.Barks of Virola sebifera (Myristicaceae used by Amazonian Indian communities in hallucinogenic snuff preparations have yielded dimethyltryptamine and derivatives. Considering the importance of the alkaloids isolated from plants for the development of chemotherapy, and the presence of these compounds in several Virola species, the scope of this work was to evaluate the antiproliferative activity of the extracts and the organic fraction from Virola sebifera leaves. The crude dichloromethane extract was the most active with selectivity for lung line (NCI-460 - IC50: 4.46 µg/mL, as well as the organic fraction (OF - IC50: 6.91 µg/mL. The observed activity could probably be attributed to alkaloids or nitrogen compounds that were evidenced by the Dragendorff reagent. However, the

  14. Levantamento das atitudes e crenças dos ortodontistas com relação à disfunção têmporo-mandibular e dor orofacial Survey of attitudes and beliefs of orthodontists regarding temporomandibular disfunction and orofacial pain

    Directory of Open Access Journals (Sweden)

    Estephan José Moana Filho

    2005-08-01

    of the most recent and validated articles pertinent to the theme and also the use of the Evidence-Based Dentistry(EBD as a way for professionals acquire self-sufficiency in the critical appraisal of the available literature.

  15. Processing-property relationships in epoxy resin/titanium dioxide nanocomposites

    Energy Technology Data Exchange (ETDEWEB)

    Polyzos, Georgios [ORNL; Tuncer, Enis [ORNL; Sauers, Isidor [ORNL; More, Karren Leslie [ORNL

    2010-01-01

    obtained from conventional, ex situ synthesis that requires high shear mixing of the organic and inorganic phases. Using the ex situ technique, we synthesized TiO{sub 2} particles (also {le}5nm in diameter) in a polyethylene glycol solution - see Figure 1(c) - and subsequently mixed them with the resin. The mixing process, even at low concentrations (1% by weight), resulted in the formation of aggregates of several hundred nanometers in size. We performed optical, thermomechanical, and electrical measurements of systems with similar weight fractions of TiO{sub 2} to evaluate the impact of particle size and dispersion on the macroscopic properties of the nanocomposite. In agreement with the TEM images, UV-visible transmittance spectra show the same optical properties for the unfilled resin and in situ nanocomposite owing to the small particle-cluster size. Because of the formation of clusters of comparable size to the wavelength of light in the visible range, the ex situ specimen showed decreased transmittance, producing an opaque composite. Moreover, we found that creating large and weak interfaces between the phases degrades the macroscopic thermomechanical and electrical properties of the specimen. The in situ nanocomposite exhibited superior mechanical performance compared to both the unfilled resin and ex situ nanocomposite over the entire temperature range. Notably, at the lowest measured temperature (-145 C), the increase in the storage modulus (G') relative to that of the unfilled resin is approximately 30%. Furthermore, the in situ technique did not degrade the thermodynamic properties of the polymer network. The glass-transition temperature (T{sub g}) remains unchanged. In contrast, the ex situ nanocomposite displayed a 55% relative decrease in Tg because of the formation of weak and large interfaces. This morphology is also associated with significant degradation of dielectric properties under high electric fields. The dielectric-breakdown strength (EBD) of

  16. Five-year examination of utilization and drug cost outcomes associated with benefit design changes including reference pricing for proton pump inhibitors in a state employee health plan.

    Science.gov (United States)

    Johnson, Jill T; Neill, Kathryn K; Davis, Dwight A

    2011-04-01

    The Arkansas State Employee Benefits Division (EBD) is a self-insured program comprising public school and other state employees, their spouses, and dependents. Previous research published in JMCP (2006) showed drug cost savings of $2.20 per member per month (PMPM; 37.6%) or annualized savings of $3.4 million associated with a benefit design change and coverage of the proton pump inhibitor (PPI) omeprazole over-the-counter (OTC) beginning in March 2004. On May 1, 2005, brand esomeprazole was excluded from coverage, with current users grandfathered for 4 months until September 2005. Reference pricing for PPIs, including esomeprazole but excluding generic omeprazole, was implemented on September 1, 2005, and the beneficiary cost share for all PPIs except generic omeprazole was determined from comparison of the PPI actual price to the $0.90 omeprazole OTC reference price per unit. To examine PPI utilization and drug costs before and after (a) excluding esomeprazole from coverage (with grandfathering current users) and (b) implementing a therapeutic maximum allowable cost (TMAC), or reference-pricing benefit design, for the PPI class in a large state employee health plan with fairly stable enrollment of approximately 127,500 members in 2005 through 2008 and approximately 128,000 members in 2009 Q1. The pharmacy claims database for the EBD was used to examine utilization and cost data for PPIs in a longitudinal analysis for the 61-month period from March 1, 2004, through March 31, 2009. Pharmacy claims data were compared for the period 14 months prior to esomeprazole exclusion (preperiod), 4 months during the esomeprazole exclusion (postperiod 1), and the ensuing 43 months of PPI reference pricing (postperiod 2). PPI cost and utilization data for the intervention group of approximately 127,500 beneficiaries were compared with a group of 122 self-insured employers with a total of nearly 1 million beneficiaries whose pharmacy benefits did not include reference pricing for

  17. [Clinical observation of treating 62 patients with severe aplastic anemia failing in immunosuppressive therapy by integrative medicine].

    Science.gov (United States)

    Su, Er-yun; Fang, Yu-hua; Chen, Hui-shu

    2012-12-01

    To explore treatment methods for patients with severe aplastic anemia (SAA) failing in immunosuppressive therapy (IST). Totally 62 SAA patients failing in IST were treated by integrative medicine (IM). The treatment course was divided into three stages: the critical emergency stage, the improvement stage, and the recovery stage. In the critical emergency stage, patients were treated with Lingyang Yigui Decoction (LYD, consisting of 1.2 g antelope horn, 6 g coptis chinensis, 12 g stir-baked Fructus Gardeniae, 30 g rehmannia rhizoma, 50 g lalang grass rhizome, 9 g amur corktree bark, 12 g Cortex Moutan, 9 g ass-hide gelatin, 30 g red date, 6 g prepared licorice root, etc.) and Erzhi Busui Decoction (EBD, consisting of 120 g glossy privet fruit, 100 g eclipta prostrata, 24 g prepared Gold Theragran, 12 g fructus lycii, 90 g rehmannia rhizoma, 60 g astragalus, 9 g Angelica sinensis, 9 g ass-hide gelatin, 30 g honeysuckle flower, 12 g lotus plumule, and so on) alternatively, one dose daily, decocted twice, taken in two portions. Meanwhile, 50 mg Testosterone Propionate was intramuscularly injected every other day to the improvement stage. Those with fever were treated with LYD by adding 60 g gypsum, 60 g common anemarrhena, 30 g dandelion, 30 g bittersweet herb, 30 g blackend swallowwort root and rhizome, 15 g hemsley rockvine root tuber, and so on. In the improvement stage patients were treated with Jixueteng Compound (Jixueteng Zhengyang Decoction was administered to those of Shen-yang deficiency syndrome: consisting of 100 g spatholobus suberectus, 60 g astragalus, 3 g red ginseng, 12 g psoralea corylifolia, 18 g dodder seed, 12 g angelica, 18 g Herba Epimedii, 6 g common fenugreek seed, 24 g Gold Theragran, 30 g glossy privet fruit, 30 g eclipta prostrata, 6 g dried human placenta, and so on). Meanwhile, 50 mg Testosterone Propionate was intramuscularly injected every other day. Jixueteng Yijing Decoction was administered to those of Shen-yin deficiency syndrome

  18. Hauptschülers’ Conceptions of Work – An Exclusion from the Subjective Dissolution of Boundaries?/Hauptschüler und ihre Vorstellung von Arbeit – eine Ausgrenzung von der subjektivierten Entgrenzung?

    Directory of Open Access Journals (Sweden)

    Carolin Kölzer

    2011-10-01

    sich die Erfahrungen, die Hauptschüler mit Arbeit sammeln, einseitig auf atypische, unsichere Beschäftigungsverhältnisse mit hohem Prekaritätsrisiko konzentrieren sowie auf Normalarbeitsverhältnisse, beschränkt auf Berufe mit niedrigem Status, schlechter Bezahlung und hohen Gesundheitsrisiken. Privilegierte Tätigkeiten mit hohem Subjektivierungsgrad bleiben ihnen meist vorenthalten. Diese institutionell und sozial erzeugte eher einseitige Erfahrungskonzentration verursacht daher im Prozess der emotionalen Konditionierung einen eher engen Arbeitsbegriff. Gleichzeitig stellt Subjektivierung zusammen mit ihren Entgrenzungsphänomenenzunehmend eine „generelle Anforderungsstruktur an alle Beschäftigten“ (Lohr, Nickel 2005, 217 dar. Um sich auf „Arbeitsanforderungen mit höherem Gehalt an subjektiven Flexibilitäts- und Selbstgestaltungspotenzialen einzustellen“ (ebd., 221, – so meine These – bedarf es allerdings vorab einer differenzierteren Vorstellung von Arbeit, insbesondere ein Bewusstsein für die Subjektivierung von Erwerbsarbeit mit ihren Entgrenzungsphänomenen. Doch treten die befragten Hauptschüler mit einer eher einseitigen, negativen und vorwiegend fordistisch geprägten Perspektive auf Arbeit in den Lernprozess und später wahrscheinlich auch in den Arbeitsmarkt ein, wenn es Schule und Unterricht nicht gelingt, diese Vorstellungen zu erweitern und zu differenzieren. Insofern kann von einer Ausgrenzung von subjektiver Entgrenzung aufgrund eines unzureichenden Arbeitsbegriffes und einer mit aktuellen Anforderungen wenig kompatiblen Arbeitseinstellung gesprochen werden.

  19. Rainfall spatiotemporal variability relation to wetlands hydroperiods

    Science.gov (United States)

    Serrano-Hidalgo, Carmen; Guardiola-Albert, Carolina; Fernandez-Naranjo, Nuria

    2017-04-01

    hydroperiods of wetlands present in Doñana natural space. Key issues: spatiotemporal variability, geostatistics, hydroperiod, wetlands. References: Cifuentes, V., García, M.A., Checa, M.J. & Escudero, R. (2015). Estimación por teledetección de la superficie de la lámina de agua y los niveles de profundidad de las lagunas en los humedales de la Campiña Andaluza Central incluidos en la demarcación hidrográfica del Guadalquivir. Teledetección: Humedales y Espacios Protegidos. Presented in XVI Congreso de la Asociación Española de Teledetección. pp. 322-325. Sevilla 21-23 octubre 2015. http://ocs.ebd.csic.es/index.php/AET/2015/schedConf/presentations Díaz-Delgado, R., Carro, F., Herruzo, F. Q., Osuna, A., & Baena, M. (2016). Contribución del seguimiento ecológico a largo plazo a la investigación y la gestión en la plataforma LTSER-Doñana. Revista Ecosistemas, 25(1), 9-18. Pebesma, E. (2012). spacetime: Spatio-temporal data in r. Journal of Statistical Software, 51(7), 1-30.

  20. Seeding Experiment of Liquid Carbon Dioxide for Enhancing Winter-time Precipitation in Saga Prefecture,Northern Kyushu,Japan

    Science.gov (United States)

    Wakimizu, K.; Nishiyama, K.; Tomine, K.; Maki, T.; Suzuki, Y.; Morita, O.

    2012-12-01

    Many droughts (shortage of water) have broken out by extreme small amount rainfall in recent Japan. So far,in order to prevent these droughts,artificial rainfall methods with 'AgI' or 'dry ice' have been widely used in Japan. However,these methods have many problems,which a large amount of overcooling liquid in the cumulus cloud was not able to be converted into precipitation efficiently. So as to solve these problems,new artificial rainfall method using liquid carbon dioxide (LC) was proposed by Fukuta (1996). This new method consists of the generation of ice particles by homogeneous nucleation using LC and the subsequent more effective growth for ice particles without competition process. And, this method is called 'Low-Level Penetration Seeding of Homogeneous Ice Nucleant (LOLEPSHIN)' ; this induces a 'Roll-up Expansion of Twin Horizontal Ice-crystal Thermals (RETHIT)' and a subsequent 'Falling growth-Induced Lateral Air Spreading (FILAS)'. This LC method was applied to thin super-cooled cumulus clouds in Saga prefecture, Northern Kyushu, Japan on February 4,2006. The seeding airplane took off the Atugi Airport in Kanagawa Prefecture toward the Iki Island around 0830JST. Many cloud bands were cofirmed in the flight going to the experimental area and the cloud base temperature was approximately -9C (1200m). Scince some young developing thin cumuli were found over the Iki Island, LC seeding to these clouds was carried out two times from 0841JST until 0919JST penetrating the -9C (1200m) altitude. The first precipitation seeding ebded in failure. The second penetration seeding was done for 115 seconds around 0917JST. This penetration led to success of developing one artificial echo (Echo I) in the leeward side of the Iki Island. Eco I moved from NNW to SSW. The maximum area of Echo I were 48km2 (at 1033JST) and first comfirmed by the Kyushu University radar (KU radar) at 1006JST (46 min. after LC seeding) around Mt.Sefuri in Saga Prefecture. It can be inferred that

  1. Transtorno do comportamento alimentar em atletas de elite de nado sincronizado Eating disorders in elite synchronized swimmers

    Directory of Open Access Journals (Sweden)

    Talita Adão Perini

    2009-02-01

    Full Text Available OBJETIVOS: O objetivo do presente estudo foi identificar a presença de transtorno do comportamento alimentar (TCA ou síndromes precursoras e o grau de distorção da imagem corporal em atletas de elite de nado sincronizado. Essa modalidade é considerada de risco para desenvolvimento de TCA por valorizar, além de outros aspectos, a leveza e beleza de movimentos que, de certa forma, estão associados a baixa massa corporal. MÉTODOS: Foram avaliadas 27 atletas de nado sincronizado, sendo 19 da categoria juniores (15,6 ± 0,8 anos e oito da categoria de seniores (19,0 ± 1,3 anos que compunham a seleção brasileira na época do estudo (2000. Um grupo de 32 adolescentes não-atletas (15,0 ± 1,6 anos foi usado para comparação com as atletas. Os procedimentos metodológicos adotados foram: aplicação de três instrumentos de auto-relato, validados. 1 EAT-26 - presença de comportamentos alimentares inadequados; 2 BITE - presença de atitudes sugestivas de bulimia nervosa; e 3 BSQ - insatisfação da auto-imagem corporal. RESULTADOS: Embora tanto o grupo de atletas, quanto o de não-atletas tenham apresentado parâmetros antropométricos compatíveis com padrões saudáveis para a idade e sexo, os resultados evidenciam a presença de insatisfação com a auto-imagem corporal e a adoção de práticas patológicas de controle da massa corporal, sobretudo entre atletas da categoria juniores e entre as adolescentes não-atletas. CONCLUSÕES: Os resultados encontrados no presente estudo retratam uma tendência mundial de preocupação com a aparência entre adolescentes capaz de levá-las à adoção de condutas não-saudáveis.OBJECTIVES: The aim of the present study was to identify the Eating Behavior Disorder (EBD or precursory syndromes and the level of distortion of the body image of elite synchronized swimming athletes. This sport modality is considered of risk for development of eating disorders for valuing, among other aspects, the

  2. Clinical Observation of Treating 62 Patients with Severe Aplastic Anemia Failing in Immunosuppressive Therapy by Integrative Medicine%中西医结合治疗62例免疫抑制治疗无效的重型再生障碍性贫血临床观察

    Institute of Scientific and Technical Information of China (English)

    苏尔云; 方玉华; 陈辉树

    2012-01-01

    patients failing in IST were treated by integrative medicine (IM). The treatment course was divided into three stages: the critical emergency stage, the improvement stage, and the recovery stage. In the critical emergency stage, patients were treated with Lingyang Yigui Decoction (LYD, consisting of 1. 2 g antelope horn, 6 g coptis chinensis, 12 g stir-baked Fructus Gar-deniae, 30 g rehmannia rhizoma, 50 g lalang grass rhizome, 9 g amur corktree bark, 12 g Cortex Moutan, 9 g ass-hide gelatin, 30 g red date, 6 g prepared licorice root, etc.) and Erzhi Busui Decoction (EBD, consisting of 120 g glossy privet fruit, 100 g eclipta prostrata, 24 g prepared Gold Theragran, 12 g fructus lycii, 90 g rehmannia rhizoma, 60 g astragalus, 9 g Angelica sinensis, 9 g ass-hide gelatin, 30 g honeysuckle flower, 12 g lotus plumule, and so on) alternatively, one dose daily, decocted twice, taken in two portions. Meanwhile, 50 mg Testosterone Propionate was intramuscularly injected every other day to the improvement stage. Those with fever were treated with LYD by adding 60 g gypsum, 60 g common anemarrhena, 30 g dandelion, 30 g bittersweet herb, 30 g blackend swallowwort root and rhizome, 15 g hemsley rockvine root tuber, and so on. In the improve-ment stage patients were treated with Jixueteng Compound (Jixueteng Zhengyang Decoction was administered to those of Shen-yang deficiency syndrome: consisting of 100 g spatholobus suberectus, 60 g astragalus, 3 g red ginseng, 12 g psoralea corylifolia, 18 g dodder seed, 12 g angelica, 18 g Herba Epimedii, 6 g common fenugreek seed, 24 g Gold Theragran, 30 g glossy privet fruit, 30 g eclipta prostrata, 6 g dried human placenta, and so on). Meanwhile, 50 mg Testosterone Propionate was intramuscularly injected every other day. Jixueteng Yi-jing Decoction was administered to those of Shen-yin deficiency syndrome: consisting of 100 g glossy privet fruit, 100 g eclipta prostrata, 90 g rehmannia rhizoma, 30 g spatholobus suberectus, 12 g dodder seed, 6 g