WorldWideScience

Sample records for eas longitudinal development

  1. A Multi-Level Investigation into the Antecedents of Enterprise Architecture (EA) Assimilation in the U.S. Federal Government: A Longitudinal Mixed Methods Research Study

    Science.gov (United States)

    Makiya, George K.

    2012-01-01

    This dissertation reports on a multi-dimensional longitudinal investigation of the factors that influence Enterprise Architecture (EA) diffusion and assimilation within the U.S. federal government. The study uses publicly available datasets of 123 U.S. federal departments and agencies, as well as interview data among CIOs and EA managers within…

  2. Arrival time and incidence angle distributions of extensive air showers (EAS) muons

    International Nuclear Information System (INIS)

    Brancus, I.M.; Duma, M.; Vulpescu, B.; Foeller, M.; Rebel, H.; Voelker, G.; Chilingarian, A.A.

    1995-01-01

    The arrival time distributions of the muons can be related to the longitudinal EAS development and may provide additional information about the nature of the primary. Based on EAS simulations using the Monte-Carlo code CORSIKA, the correlations between arrival time and incidence angle distributions have been investigated in a case of a set of ideal detectors (10 m x 10 m) placed at various distances from the shower core. Applying advanced statistical techniques based on Bayes decision rule and non-parametric multivariate analysing methods it turns out that the correlations of muon arrival time and incidence angle at various separating distances of about 50 m exhibit promising features for mass discrimination (author)

  3. Investigation of EAS cores

    Directory of Open Access Journals (Sweden)

    Shaulov S.B.

    2017-01-01

    Full Text Available The development of nuclear-electromagnetic cascade models in air in the late forties have shown informational content of the study of cores of extensive air showers (EAS. These investigations were the main goal in different experiments which were carried out over many years by a variety of methods. Outcomes of such investigations obtained in the HADRON experiment using an X-ray emulsion chamber (XREC as a core detector are considered. The Ne spectrum of EAS associated with γ-ray families, spectra of γ-rays (hadrons in EAS cores and the Ne dependence of the muon number, ⟨Nμ⟩, in EAS with γ-ray families are obtained for the first time at energies of 1015–1017 eV with this method. A number of new effects were observed, namely, an abnormal scaling violation in hadron spectra which are fundamentally different from model predictions, an excess of muon number in EAS associated with γ-ray families, and the penetrating component in EAS cores. It is supposed that the abnormal behavior of γ-ray spectra and Ne dependence of the muon number are explained by the emergence of a penetrating component in the 1st PCR spectrum ‘knee’ range. Nuclear and astrophysical explanations of the origin of the penetrating component are discussed. The necessity of considering the contribution of a single close cosmic-ray source to explain the PCR spectrum in the knee range is noted.

  4. The time structure of the EAS muon component observed in the KASCADE experiment

    International Nuclear Information System (INIS)

    Brancus, I.M.; Badea, A.F.; Duma, M.; Vulpescu, B.; Rebel, H.; Haeusler, R.; Mathes, H.J.

    1998-01-01

    The determination of the chemical composition in the energy range of 10 15 eV is the scientific goal of the KASCADE (Karlsruhe Shower Core and Array Detector) experiment. Under this aspect, the temporal structure of the muon component of extended air showers (EAS) is of great interest for a detailed understanding of the EAS features, since the muon arrival time distribution maps the longitudinal EAS development via the time-of-flight of muons produced in large atmospheric heights and shows effects for mass discrimination of the EAS primaries. Using the muon detection and timing facilities of the KASCADE Central Detector, in particular the 'trigger' layer of 456 scintillation detectors and the position-sensitive large-area multiwire proportional chambers, installed under the hadron calorimeter, the muon arrival time distributions (E μ ≥ 2 GeV) registered relative to the arrival of the foremost muons have been measured. Their dependence on various shower quantities, the distance from the shower center R μ , the zenith angle Θ of shower incidence and muon shower content N μ tr (which is an identifier of the primary energy), have been studied. We characterize the single arrival time distribution by various different moments: the median Δτ 0.50 , the 1 st and the 3 rd quartiles (Δτ 0.25 and Δτ 0.75 ) which express different features of the distributions. The dependence of the measured median distributions on the distance from the shower center for a restricted Θ-range and averaged over the observed shower size spectrum is presented. The shapes can be approximated by a gamma probability distribution function. There are also displayed the mean values (Δτ 0.50 ) and the dispersion σ 0.50 of the median distributions, whose R μ -variations represent the (median) profile on the EAS muon disc. The theoretical interpretation of this kind of experimental results on the basis of Monte Carlo simulations of the EAS development is under progress. (authors)

  5. Business Architecture Development at Public Administration - Insights from Government EA Method Engineering Project in Finland

    Science.gov (United States)

    Valtonen, Katariina; Leppänen, Mauri

    Governments worldwide are concerned for efficient production of services to customers. To improve quality of services and to make service production more efficient, information and communication technology (ICT) is largely exploited in public administration (PA). Succeeding in this exploitation calls for large-scale planning which embraces issues from strategic to technological level. In this planning the notion of enterprise architecture (EA) is commonly applied. One of the sub-architectures of EA is business architecture (BA). BA planning is challenging in PA due to a large number of stakeholders, a wide set of customers, and solid and hierarchical structures of organizations. To support EA planning in Finland, a project to engineer a government EA (GEA) method was launched. In this chapter, we analyze the discussions and outputs of the project workshops and reflect emerged issues on current e-government literature. We bring forth insights into and suggestions for government BA and its development.

  6. NOAA Weather Radio - EAS Description

    Science.gov (United States)

    Non-Zero All Hazards Logo Emergency Alert Description Event Codes Fact Sheet FAQ Organization Search Search For Go NWS All NOAA Emergency Alert System (EAS) List of EAS Event Codes NWS EAS fact sheet What Management Agency (FEMA) and the NWS, implements the EAS at the federal level. The EAS is the nation's public

  7. Comparison of absolute intensity between EAS with gamma families and general EAS at Mount Norikura

    International Nuclear Information System (INIS)

    Mitsumune, T.; Nakatsuka, T.; Nishikawa, K.

    1985-01-01

    Gamma families with total energy greater than 10 TeV, found in the EX chamber which was cooperated with the EAS array, were combined with EAS triggered by big bursts. The absolute intensity of the size spectrum of these combined EAS was compared with that of general EAS obtained by AS trigger. The EAS with sizes greater than 2x1 million were always accompanied by gamma families with sigma E sub gamma H 10 TeV, n sub gamma, H 2 and Emin=3 TeV, although the rate of EAS accompaning such gamma families decreases rapidly as their sizes decrease

  8. Performance comparisons between PCA-EA-LBG and PCA-LBG-EA approaches in VQ codebook generation for image compression

    Science.gov (United States)

    Tsai, Jinn-Tsong; Chou, Ping-Yi; Chou, Jyh-Horng

    2015-11-01

    The aim of this study is to generate vector quantisation (VQ) codebooks by integrating principle component analysis (PCA) algorithm, Linde-Buzo-Gray (LBG) algorithm, and evolutionary algorithms (EAs). The EAs include genetic algorithm (GA), particle swarm optimisation (PSO), honey bee mating optimisation (HBMO), and firefly algorithm (FF). The study is to provide performance comparisons between PCA-EA-LBG and PCA-LBG-EA approaches. The PCA-EA-LBG approaches contain PCA-GA-LBG, PCA-PSO-LBG, PCA-HBMO-LBG, and PCA-FF-LBG, while the PCA-LBG-EA approaches contain PCA-LBG, PCA-LBG-GA, PCA-LBG-PSO, PCA-LBG-HBMO, and PCA-LBG-FF. All training vectors of test images are grouped according to PCA. The PCA-EA-LBG used the vectors grouped by PCA as initial individuals, and the best solution gained by the EAs was given for LBG to discover a codebook. The PCA-LBG approach is to use the PCA to select vectors as initial individuals for LBG to find a codebook. The PCA-LBG-EA used the final result of PCA-LBG as an initial individual for EAs to find a codebook. The search schemes in PCA-EA-LBG first used global search and then applied local search skill, while in PCA-LBG-EA first used local search and then employed global search skill. The results verify that the PCA-EA-LBG indeed gain superior results compared to the PCA-LBG-EA, because the PCA-EA-LBG explores a global area to find a solution, and then exploits a better one from the local area of the solution. Furthermore the proposed PCA-EA-LBG approaches in designing VQ codebooks outperform existing approaches shown in the literature.

  9. EA Training 2.0 Newsletter #3 - EA Active, Problem Based Learning Methodology

    DEFF Research Database (Denmark)

    Buus, Lillian; Ryberg, Thomas; Sroga, Magdalena

    2010-01-01

    The main products of the project are innovative, active problem-based learning methodology for EA education and training, EA courses for university students and private and public sector employees, and an Enterprise Architecture competence ontology including a complete specification of skills...

  10. Hydroelectric project EA's [environmental assessments]: The Magpie development in northern Ontario

    International Nuclear Information System (INIS)

    Ashwood, K.

    1992-01-01

    Great Lakes Power recently constructed a hydroelectric plant on the Magpie River near Wawa, Ontario. The project involved three main elements: construction of a 33 m high dam, a 15.5 MW power station, and a spillway at Steephill Falls; construction of a 3.5 m high overflow weir just above the crest of scenic Magpie Falls, creating a head pond to supply a 15 MW power plant; and construction of a weir and 15 MW power plant at Mission Falls. Although this was a private development and therefore not automatically subject to Ontario's Environmental Assessment Act, Great Lakes Power decided to conform with the act's requirements and undertook a comprehensive environmental assessment (EA). Environmental issues were focused on changes in hydrology and water quality, impacts on fisheries and natural resources, slope stability and erosion, socioeconomic impacts, impacts on heritage resources, and impacts on tourism and recreation. The project was approved subject to conditions which included implementation of mitigation and monitoring requirements outlined in the EA document. Environmental specialists worked closely with the engineers at the detailed design stage of the project, resulting in modifications to the preliminary design to minimize environmental impacts

  11. Reconceptualizing public participation in environmental assessment as EA civics

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, A. John, E-mail: jsincla@umanitoba.ca [Natural Resources Institute, University of Manitoba, Winnipeg, MB R3T 2N2 (Canada); Diduck, Alan P., E-mail: a.diduck@uwinnipeg.ca [Department of Environmental Studies and Sciences, University of Winnipeg, 515 Portage Avenue, Winnipeg R3B 2E9 (Canada)

    2017-01-15

    Notwithstanding the considerable attention placed on creating meaningful opportunities for public participation in environmental assessment (EA), many participants and those who have reviewed participation processes often find practice sorely wanting. This reality stands in stark juxtaposition to future environmental governance needs, which will require increased openness, deliberation and transdisciplinary knowledge in order to deal with environmental change that is ever more uncertain, complex and conflictual. In this paper, our purpose was to consider how to meet those needs through reconceptualizing public participation as EA civics, founded on an active citizen base, deliberative in nature and orientated toward learning. We do this through developing a new conceptual model of next generation participation processes that is relevant at multiple spatial scales and institutional levels, is applicable to the entire assessment cycle and spans temporal scales through feedback loops. Our EA civics model builds on the “civics approach” to environmental governance and “action civics” by extending their core ideas to participation in EA. We did this by conducting an integrative literature review (including numerous papers we have contributed over the years) and reflecting on our own experiences as EA participants. We apply current thinking on public participation design to our EA civics conceptualization and highlight important design features that have received scant attention. We conclude that EA civics holds promise for fairer and more robust participation processes if all aspects of the model are considered and the actions related to each are implemented. - Highlights: • Consideration of the ‘civics approach’ and ‘action civics’ in an EA context • Conceptualization of public participation as EA civics • Reflection on the EA civics as a model of participation suitable for next generation assessment.

  12. Reconceptualizing public participation in environmental assessment as EA civics

    International Nuclear Information System (INIS)

    Sinclair, A. John; Diduck, Alan P.

    2017-01-01

    Notwithstanding the considerable attention placed on creating meaningful opportunities for public participation in environmental assessment (EA), many participants and those who have reviewed participation processes often find practice sorely wanting. This reality stands in stark juxtaposition to future environmental governance needs, which will require increased openness, deliberation and transdisciplinary knowledge in order to deal with environmental change that is ever more uncertain, complex and conflictual. In this paper, our purpose was to consider how to meet those needs through reconceptualizing public participation as EA civics, founded on an active citizen base, deliberative in nature and orientated toward learning. We do this through developing a new conceptual model of next generation participation processes that is relevant at multiple spatial scales and institutional levels, is applicable to the entire assessment cycle and spans temporal scales through feedback loops. Our EA civics model builds on the “civics approach” to environmental governance and “action civics” by extending their core ideas to participation in EA. We did this by conducting an integrative literature review (including numerous papers we have contributed over the years) and reflecting on our own experiences as EA participants. We apply current thinking on public participation design to our EA civics conceptualization and highlight important design features that have received scant attention. We conclude that EA civics holds promise for fairer and more robust participation processes if all aspects of the model are considered and the actions related to each are implemented. - Highlights: • Consideration of the ‘civics approach’ and ‘action civics’ in an EA context • Conceptualization of public participation as EA civics • Reflection on the EA civics as a model of participation suitable for next generation assessment

  13. D1.1 Stakeholders Needs Regarding EA

    DEFF Research Database (Denmark)

    Ryberg, Thomas; Eleftheriou, Paraskevi; Maglavera, Stavroula

    2009-01-01

    The objective of this deliverable is to identify and document the competences (skills and knowledge) that employees of both private and public sector organisations need to acquire in order to be capable of developing an EA as well as the competences that university students need to acquire in a u...... competences comprising professional skills, personal skills and knowledge. Finally, three detailed lists of EA related competences are presented for the three target groups of the project i.e. private sector employees, public sector employees and university students....

  14. EAS experiment on board the Airbus A380

    International Nuclear Information System (INIS)

    Capdevielle, J.N.; Cohen, F.; Jedrzejczak, K.; Szabelska, B.; Szabelski, J.; Wibig, T.

    2006-01-01

    We consider taking the opportunity of about 10,000 hours of test flights of the Airbus A380, and to install in the passenger area detectors for high energy cosmic ray events. The altitude of 10 km (250 g/cm 2 ) presents the opportunity to measure EAS originating from heavy primaries to energies exceeding 10 7 GeV, and also the proton component beyond the energy of the knee arriving without interaction. At the flight altitude iron originated EAS are well developed and by registering their lateral distribution in the 70 meters long cabin it will be possible to distinguish them from proton originated EAS. The hadron component of EAS (registered as number of secondary hadrons produced in the detector) would help in discrimination and energy estimation. On the other hand, the detection of high energy protons (without EAS) would enable us to measure the high energy proton spectrum. The proton energy would be estimated via hadron multiplicity in single interactions inside the detector. We propose to use about 60 modules of 0.5 m 2 of active detectors with scintillators to detect E-M component and a carbon target with lead layer to detect the hadronic component via neutron registrations

  15. 47 CFR 11.31 - EAS protocol.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false EAS protocol. 11.31 Section 11.31... characters. FM or TV call signs must use a slash ASCII character number 47 (/) in lieu of a dash. (c) The EAS... the State EAS Mapbook. FIPS# State: AL 01 AK 02 AZ 04 AR 05 CA 06 CO 08 CT 09 DE 10 DC 11 FL 12 GA 13...

  16. Analysis of ethyl acrylate (EA) and acrylic acid (AA) residues from rat tissues following oral ea dosing

    International Nuclear Information System (INIS)

    Udinsky, J.R.; Frederick, C.B.

    1990-01-01

    Gavage dosing of rats with EA at high dose levels (100 or 200 mg/kg) has resulted in tumors at the dosing site, forestomach (FST), but no lesions of the glandular stomach (GST) or other remote tissues. Since previous in vitro studies have demonstrated that EA is very rapidly metabolized to AA and glutathione conjugates, EA and AA residues were analyzed 0-24 hr following gavage dosing of non-fasted F-344/N male rats with [1- 14 C]EA in corn oil at 10, 50, and 200 mg/kg. Analysis of total 14 C indicated that the dose solution was primarily in the FST at ≥5 min after dosing, although 14 C was detected in the GST, duodenum, and small intestine (attributed to distension of the FST and leakage from the FST to the GST). HPLC analysis of the gut contents, gut wall, liver, kidneys, lungs, and blood indicated that EA and AA could only be detected at ≥15 min in the FST and GST contents, and in the FST tissue. AA alone was detected in the GST tissue, duodenum tissue and contents, and small intestine tissue and contents. The minimum level of detection was 0.0005% of the dose. The remaining 14 C was primarily attributed to binding to the gut contents or bioincorporation of AA. The detection of EA and AA residues only in the upper gastrointestinal tract following gavage dosing is consistent with rapid detoxification of EA by hydrolysis and conjugation which prevents toxicity at sites remote form the site of dosing

  17. A new paradigm for Environmental Assessment (EA) in Korea

    International Nuclear Information System (INIS)

    Song, Young-Il; Glasson, John

    2010-01-01

    Over the last 30 years, Environmental Impact Assessment (EIA) in Korea has played an important role in decision-making processes particularly for environmentally sensitive projects. However, the EIA system alone has sometimes not been effective enough to ensure the successful resolution of environmental concerns. In order to compensate for the limitations of the EIA system, a new assessment system called Prior Environmental Review System (PERS), which is relevant to Strategic Environmental Assessment (SEA) in some aspects, was introduced in 1993. PERS aims to balance development and preservation by identifying possible environmental impacts of some administrative plans mainly related to development projects in the early stages of planning. However, PERS still appeared to have some weak points such as a limited range of subjects to be assessed, and weakness of tiering (or vertical integration) from PERS to EIA. Therefore, the necessity for reform of the Korean Environmental Assessment (EA) system, including PERS, was raised. In response, the Korean government sought to establish its policy direction for implementing SEA by enhancing the objectivity and expertise of PERS. The policy was approved by the National Assembly in May 2005, and went into effect in June 2006. The introduction of SEA, by enhancing PERS, provides a framework for a system of EA from the strategic level, including PPPs, to the project level. Yet, despite such improvements, some managerial and technical problems associated with subsequent EA implementation remain. This paper critically reviews the evolution of the EA system in Korea and suggests essential improvements for the current EA system based on experiences of implementation of both EIA and SEA since June 2006, in the context of international good practice.

  18. Synthesis and optimization of EA-MMA copolymer emulsion%EA-MMA共聚乳液合成工艺及优化

    Institute of Scientific and Technical Information of China (English)

    张成芬; 武玉民

    2011-01-01

    以丙烯酸乙酯(EA)和甲基丙烯酸甲酯(MMA)为共聚单体、过硫酸钾(KPS)为引发剂、十二烷基硫酸钠(SDS)和壬基酚聚氧乙烯醚(OP-10)为复合乳化剂,采用乳液聚合法合成出一种稳定的EA-MMA乳液.通过单因素试验法考察了乳化剂浓度、引发剂浓度、反应温度和反应时间等因素对乳液平均粒径和单体转化率的影响,并采用正交试验法进一步优选出制备EA-MMA乳液的最佳工艺条件.结果表明:当w(乳化剂)=2.0%、w(引发剂)=0.60%、反应时间为4 h和反应温度为80℃时,制成的EA-MMA乳液较稳定,并且单体转化率相对最高.%With ethyl acrylate(EA) and methyl methacrylate( MMA) as comonomers ,potassium persulfate(KPS)as initiator,and sodium dodecyl sulfate(SDS) and nonylphenol ethoxylates(OP-10) as composite emulsifier,a stable EA-MMA emulsion was synthesized by emulsion polymerization. The influences of some factor(such as emulsifier concentration,initiator concentration,reaction temperature and reaction time) on average particle size of emulsion and monomer conversion rate were investigated by single factor experiment method,then the optimal process conditions of preparing EA-MMA emulsion were preferred by orthogonal experiment method. The results showed that the EA-MMA emulsion had better stability and relatively highest monomer conversion rate when the mass fractions of emulsifier and initiator were 2.0％ and 0.60％ respectively,the reaction time and reaction temperature were 4 h and 80 ℃ respectively.

  19. 47 CFR 11.54 - EAS operation during a National Level emergency.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false EAS operation during a National Level emergency... SYSTEM (EAS) Emergency Operations § 11.54 EAS operation during a National Level emergency. (a) The EAS Operating Handbook summarizes the procedures to be followed upon receipt of a National level EAN or EAT...

  20. Classification of EA1-box proteins and new insights into their role during reproduction in grasses.

    Science.gov (United States)

    Uebler, Susanne; Márton, Mihaela L; Dresselhaus, Thomas

    2015-12-01

    EA1-box protein classification. Success in reproduction and vegetative development in flowering plants strongly depends on precise cell-to-cell signaling events mediated by secreted peptides.A small peptide family named as EA1-like (EAL) has been first described 10 years ago and includes EA1 involved in pollen tubes attraction by the female gametophyte and EAL1-regulating germ cell identity in maize. EALs consist of an N-terminal endoplasmic reticulum-targeting motif, the highly conserved EA1-box and a short C-terminal alanine-rich domain. Whereas EAL peptides are exclusively found in the Gramineae, the EA1-box is widely distributed throughout the plant kingdom. Based on in silico analysis and subcellular localization studies, we report here a new classification of EA1-box proteins in flowering plants. They can be distinguished into three protein classes: the already defined EAL proteins, the EAG (EA1-box glycine-rich) proteins and the EAC (EA1-box containing)proteins. While fusion proteins of EAL and EAC classes locate to the secretory pathway, EAGs are cytoplasmic and locate also to the nucleus. Moreover, we further show that the third EAL protein of Zea mays, EAL2, appears to be also involved in processes related to late embryogenic development as its peptide level increases after formation of leaf primordia. Immunohistochemical studies indicate its presence in the scutellar parenchyma and around the vasculature, where it is secreted to the extracellular space. In conclusion, the members of the maize EAL family possess very diverse functions during reproduction and it will now be exciting to elucidate the functions of EAGs and EACs in plants.

  1. EAS Telecommunications Certification Bodies (TCB)

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). A Telecommunication Certification Body (TCB) is an accredited product certification body with the authority to issue Grants of...

  2. EAS Equipment Authorization Grantee Registrations

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). Radio Frequency (RF) devices are required to be properly authorized under 47 CFR Part 2 prior to being marketed or imported...

  3. 47 CFR 90.691 - Emission mask requirements for EA-based systems.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emission mask requirements for EA-based systems. 90.691 Section 90.691 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... of Ea-Based Smr Systems in the 809-824/851-869 Mhz Band § 90.691 Emission mask requirements for EA...

  4. Isolation and characterization of new lignin streams derived from extractive-ammonia (EA) pretreatment

    Energy Technology Data Exchange (ETDEWEB)

    da Costa Sousa, Leonardo [Michigan State Univ., East Lansing, MI (United States); Foston, Marcus [Washington Univ., St. Louis, MO (United States); Bokade, Vijay [National Chemical Lab., Pune (India); Azarpira, Ali [Univ. of Wisconsin, Madison, WI (United States); Lu, Fachuang [Univ. of Wisconsin, Madison, WI (United States); Ragauskas, Arthur J. [Univ. of Tennessee, Knoxville, TN (United States); Ralph, John [Univ. of Wisconsin, Madison, WI (United States); Dale, Bruce [Michigan State Univ., East Lansing, MI (United States); Balan, Venkatesh [Michigan State Univ., East Lansing, MI (United States)

    2016-05-05

    One of the key challenges facing lignin conversion to fuels and chemicals is related to the level of carbohydrate and ash impurities found in extracted lignin. Structural modifications of lignin may also occur as a result of biomass pretreatment and harsh lignin extraction protocols. Extractive-Ammonia (EA) is a new pretreatment technology that uses liquid ammonia to cleave lignin–carbohydrate complexes, decrystallize cellulose, solubilize lignin, and selectively extract lignin from lignocellulosic biomass, enabling better utilization of both lignin and carbohydrate components in a biorefinery. The EA-based biorefinery produces two different lignin-rich streams, with different properties, that could potentially be upgraded to fuels and chemicals using green processes. Here, a water/ethanol-based fractionation method was developed to enrich the ammonia-soluble extractives, resulting in a major product stream containing 92% lignin. Detailed characterization of the various streams resulting from EA treatment, including compositional analysis, structural characterization by nuclear magnetic resonance (NMR) spectrometry, elemental analysis, molecular weight analysis, and thermo-gravimetric analysis provides a broad evaluation of the EA-derived lignin product stream structures and properties, assessing their potential for commercial applications. In conclusion, EA-derived lignins preserve much of lignin's functionality, including the sensitive β-aryl ether units. Furthermore, we observed nitrogen incorporation in the lignin-rich streams, notably due to the presence of hydroxycinnamoyl amides formed during ammonia pretreatment.

  5. Physical Properties and Evolutionary States of EA-type Eclipsing Binaries Observed by LAMOST

    Science.gov (United States)

    Qian, S.-B.; Zhang, J.; He, J.-J.; Zhu, L.-Y.; Zhao, E.-G.; Shi, X.-D.; Zhou, X.; Han, Z.-T.

    2018-03-01

    About 3196 EA-type binaries (EAs) were observed by LAMOST by 2017 June 16 and their spectral types were derived. Meanwhile, the stellar atmospheric parameters of 2020 EAs were determined. In this paper, those EAs are cataloged and their physical properties and evolutionary states are investigated. The period distribution of EAs suggests that the period limit of tidal locking for the close binaries is about 6 days. It is found that the metallicity of EAs is higher than that of EW-type binaries (EWs), indicating that EAs are generally younger than EWs and they are the progenitors of EWs. The metallicities of long-period EWs (0.4values of Log (g) are usually smaller than those of EAs. These support the evolutionary process that EAs evolve into long-period EWs through the combination of angular momentum loss (AML) via magnetic braking and case A mass transfer. For short-period EWs, their metallicities are lower than those of EAs, while their gravitational accelerations are higher. These reveal that they may be formed from cool short-period EAs through AML via magnetic braking with little mass transfer. For some EWs with high metallicities, they may be contaminated by material from the evolution of unseen neutron stars and black holes or they have third bodies that may help them to form rapidly through a short timescale of pre-contact evolution. The present investigation suggests that the modern EW populations may have formed through a combination of these mechanisms.

  6. Noise properties and cascadability of SOA-EA regenerators

    DEFF Research Database (Denmark)

    Öhman, Filip; Bischoff, Svend; Tromborg, Bjarne

    2002-01-01

    We suggest and analyse a new device containing concatenated pairs of semiconductor optical amplifiers (SOAs) and electroabsorption modulators (EAs). The device has regenerative properties and improves the cascadability of optical fibre links.......We suggest and analyse a new device containing concatenated pairs of semiconductor optical amplifiers (SOAs) and electroabsorption modulators (EAs). The device has regenerative properties and improves the cascadability of optical fibre links....

  7. Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA: Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment

    Directory of Open Access Journals (Sweden)

    Hester F. Shieh

    2018-01-01

    Full Text Available PurposeWe review outcomes of posterior tracheopexy for tracheomalacia in esophageal atresia (EA patients, comparing primary treatment at the time of initial EA repair versus secondary treatment.MethodsAll EA patients who underwent posterior tracheopexy from October 2012 to September 2016 were retrospectively reviewed. Clinical symptoms, tracheomalacia scores, and persistent airway intrusion were collected. Indication for posterior tracheopexy was the presence of clinical symptoms, in combination with severe tracheomalacia as identified on bronchoscopic evaluation, typically defined as coaptation in one or more regions of the trachea. Secondary cases were usually those with chronic respiratory symptoms who underwent bronchoscopic evaluation, whereas primary cases were those found to have severe tracheomalacia on routine preoperative dynamic tracheobronchoscopy at the time of initial EA repair.ResultsA total of 118 patients underwent posterior tracheopexy: 18 (15% primary versus 100 (85% secondary cases. Median (interquartile range age was 2 months (1–4 months for primary (22% type C and 18 months (8–40 months for secondary (87% type C cases (p < 0.001. There were statistically significant improvements in most clinical symptoms postoperatively for primary and secondary cases, with no significant differences in any postoperative symptoms between the two groups (p > 0.1. Total tracheomalacia scores improved significantly in primary (p = 0.013 and secondary (p < 0.001 cases. Multivariable Cox regression analysis indicated no differences in persistent airway intrusion requiring reoperation between primary and secondary tracheopexy adjusting for imbalances in age and EA type (p = 0.67.ConclusionPosterior tracheopexy is effective in treating severe tracheomalacia with significant improvements in clinical symptoms and degree of airway collapse on bronchoscopy. With no significant differences in outcomes between primary and

  8. EA follow-up in the Ghanaian mining sector: Challenges and opportunities

    International Nuclear Information System (INIS)

    Appiah-Opoku, Seth; Bryan, Hobson C.

    2013-01-01

    Environmental assessment (EA) follow-up provides a means for monitoring and evaluating the implementation of environmental impact studies. It is integral to the success or failure of a project or program. In spite of its importance, very little attention is given to the need for follow-up programs in most jurisdictions in Africa. Using a case study in the Ghanaian mining sector, this paper explores the challenges and opportunities within the country's EA process for an effective follow-up program. The paper is based on informal interviews, content analysis of relevant publications, official EA documents, and internet searches. The authors suggest a standard EA follow-up program to be formalized as an integral part of Ghana's environmental assessment policy. They also propose a follow-up process that harnesses existing opportunities within the country's EA system. This approach can be replicated in other African countries

  9. OneVA EA Vision and Strategy

    Data.gov (United States)

    Department of Veterans Affairs — The outcomes/goals supported by effective use of an EA are: Improved Service Delivery, Functional Integration, Resource Optimization and Authoritative Reference. VA...

  10. The Tunka-133 EAS Cherenkov light array: Status of 2011

    International Nuclear Information System (INIS)

    Berezhnev, S.F.; Besson, D.; Budnev, N.M.; Chiavassa, A.; Chvalaev, O.A.; Gress, O.A.; Dyachok, A.N.; Epimakhov, S.N.; Haungs, A.; Karpov, N.I.; Kalmykov, N.N.; Konstantinov, E.N.; Korobchenko, A.V.; Korosteleva, E.E.; Kozhin, V.A.; Kuzmichev, L.A.; Lubsandorzhiev, B.K.; Lubsandorzhiev, N.B.; Mirgazov, R.R.; Panasyuk, M.I.

    2012-01-01

    A new EAS Cherenkov light array, Tunka-133, with ∼1km 2 geometrical area has been installed at the Tunka Valley (50 km from Lake Baikal) in 2009. The array permits a detailed study of cosmic ray energy spectrum and mass composition in the energy range 10 16 –10 18 eV with a uniform method. We describe the array construction, DAQ and methods of the array calibration. The method of energy reconstruction and absolute calibration of measurements are discussed. The analysis of spatial and time structure of EAS Cherenkov light allows to estimate the depth of the EAS maximum X max . The results on the all particles energy spectrum and the mean depth of the EAS maximum X max vs. primary energy derived from the data of two winter seasons (2009–2011) are presented. Preliminary results of joint operation of the Cherenkov array with antennas for the detection of EAS radio signals are shown. Plans for future upgrades – deployment of remote clusters, radioantennas and a scintillator detector network and a prototype of the HiSCORE gamma-telescope – are discussed.

  11. EAS 2.948 Listed Test Firms

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). The following firms have submitted the information required by Section 2.948 of the FCC Rules for measuring devices subject to...

  12. 75 FR 33799 - EasTrans, LLC; Notice of Baseline Filing

    Science.gov (United States)

    2010-06-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-30-000] EasTrans, LLC; Notice of Baseline Filing June 8, 2010. Take notice that on June 4, 2010, EasTrans, LLC submitted a baseline filing of its Statement of Operating Conditions for services provided under section 311 of the...

  13. EAS primary particle parameter estimation with the complex Pamir-XXI detector array

    Directory of Open Access Journals (Sweden)

    Galkin V.I.

    2017-01-01

    Full Text Available Some new developments in EAS methods made in the framework of the Pamir-XXI project are presented. First, primary energy and direction definition accuracies by a network of fast scintillators are considered, optimum network cell size is defined for 10 PeV showers. Second, the same accuracies for a network of fast optical (Cherenkov detectors are considered for 30 TeV–10 PeV showers. Third, the possibilities of separation of EAS initiated by protons, nitrogen and iron nuclei of 1 and 10 PeV energies using a wide-angle Cherenkov telescope are discussed. Finally, the results of the extraction of 30–50 TeV gamma showers from the proton shower background with the same telescope are presented. Presumably, our developments can help in the study of PCR mass composition and ultra high energy gamma ray astronomy in other projects.

  14. Expert Advisor (EA) Evaluation System Using Web-based ELECTRE Method in Foreign Exchange (Forex) Market

    Science.gov (United States)

    Satibi; Widodo, Catur Edi; Farikhin

    2018-02-01

    This research aims to optimize forex trading profit automatically using EA but its still keep considering accuracy and drawdown levels. The evaluation system will classify EA performance based on trading market sessions (Sydney, Tokyo, London and New York) to determine the right EA to be used in certain market sessions. This evaluation system is a web-based ELECTRE methods that interact in real-time with EA through web service and are able to present real-time charts performance dashboard using web socket protocol communications. Web applications are programmed using NodeJs. In the testing period, all EAs had been simulated 24 hours in all market sessions for three months, the best EA is valued by its profit, accuracy and drawdown criteria that calculated using web-based ELECTRE method. The ideas of this research are to compare the best EA on testing period with collaboration performances of each best classified EA by market sessions. This research uses three months historical data of EUR/USD as testing period and other 3 months as validation period. As a result, performance of collaboration four best EA classified by market sessions can increase profits percentage consistently in testing and validation periods and keep securing accuracy and drawdown levels.

  15. Expert Advisor (EA Evaluation System Using Web-based ELECTRE Method in Foreign Exchange (Forex Market

    Directory of Open Access Journals (Sweden)

    Satibi Satibi

    2018-01-01

    Full Text Available This research aims to optimize forex trading profit automatically using EA but its still keep considering accuracy and drawdown levels. The evaluation system will classify EA performance based on trading market sessions (Sydney, Tokyo, London and New York to determine the right EA to be used in certain market sessions. This evaluation system is a web-based ELECTRE methods that interact in real-time with EA through web service and are able to present real-time charts performance dashboard using web socket protocol communications. Web applications are programmed using NodeJs. In the testing period, all EAs had been simulated 24 hours in all market sessions for three months, the best EA is valued by its profit, accuracy and drawdown criteria that calculated using web-based ELECTRE method. The ideas of this research are to compare the best EA on testing period with collaboration performances of each best classified EA by market sessions. This research uses three months historical data of EUR/USD as testing period and other 3 months as validation period. As a result, performance of collaboration four best EA classified by market sessions can increase profits percentage consistently in testing and validation periods and keep securing accuracy and drawdown levels.

  16. (1+1) EA on Generalized Dynamic OneMax

    DEFF Research Database (Denmark)

    Kötzing, Timo; Lissovoi, Andrei; Witt, Carsten

    2015-01-01

    . We get tight bounds both for the case of bit strings, as well as for the case of more than two values per position. Surprisingly, in the latter setting, the expected quality of the search point maintained by the (1+1) EA does not depend on the number of values per dimension....... using the modern tool of drift analysis. We extend these results to search spaces which allow for more than two values per dimension. Furthermore, we make an anytime analysis as suggested by Jansen and Zarges (2014), analyzing how closely the (1+1) EA can track the dynamically moving optimum over time...

  17. Impact of conservatism on the Ea process

    International Nuclear Information System (INIS)

    Pelletier, C.A.

    1985-01-01

    Although starting out with an admitted negative view of the impact of conservatism on the Ea process, the opposite conclusion is reached. Overall, the impact of the authors conservatism has been positive

  18. 47 CFR 11.33 - EAS Decoder.

    Science.gov (United States)

    2010-10-01

    ..., satellite, public switched telephone network, or any other source that uses the EAS protocol. (2) Valid..., analog radio and television broadcast stations, analog cable systems and wireless cable systems may... program data must be retained even with power removed. (7) Outputs. Decoders shall have the following...

  19. Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea

    Energy Technology Data Exchange (ETDEWEB)

    Poudel, Bhawana [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom); Bilbao, Daniel [EMBL, Mouse Biology Unit, Monterotondo (Italy); Sarathchandra, Padmini; Germack, Renee [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom); Rosenthal, Nadia [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom); Australian Regenerative Medicine Institute, Monash University, Melbourne (Australia); Santini, Maria Paola, E-mail: m.santini@imperial.ac.uk [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom)

    2011-12-16

    Highlights: Black-Right-Pointing-Pointer In this study, we explored the function of IGF-1Ea propeptide in inducing cardiogenesis of stem cells. Black-Right-Pointing-Pointer IGF-1Ea promoted cardiac mesodermal induction in uncommitted cells. Black-Right-Pointing-Pointer Under differentiation condition, IGF-1Ea increased expression of cardiac differentiation markers. Black-Right-Pointing-Pointer Furthermore, it promoted formation of finely organized sarcomeric structure. Black-Right-Pointing-Pointer IGF-1Ea propeptide may be a good candidate to improve production of cardiomyocytes from pluripotent cells. -- Abstract: The mechanism implicated in differentiation of endogenous cardiac stem cells into cardiomyocytes to regenerate the heart tissue upon an insult remains elusive, limiting the therapeutical goals to exogenous cell injection and/or gene therapy. We have shown previously that cardiac specific overexpression of the insulin-like growth factor 1 propeptide IGF-1Ea induces beneficial myocardial repair after infarct. Although the mechanism is still under investigation, the possibility that this propeptide may be involved in promoting stem cell differentiation into the cardiac lineage has yet to be explored. To investigate whether IGF-1Ea promote cardiogenesis, we initially modified P19 embryonal carcinoma cells to express IGF-1Ea. Taking advantage of their cardiomyogenic nature, we analyzed whether overexpression of this propeptide affected cardiac differentiation program. The data herein presented showed for the first time that constitutively overexpressed IGF-1Ea increased cardiogenic differentiation program in both undifferentiated and DMSO-differentiated cells. In details, IGF-1Ea overexpression promoted localization of alpha-actinin in finely organized sarcomeric structure compared to control cells and upregulated the cardiac mesodermal marker NKX-2.5 and the ventricular structural protein MLC2v. Furthermore, activated IGF-1 signaling promoted cardiac

  20. Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea

    International Nuclear Information System (INIS)

    Poudel, Bhawana; Bilbao, Daniel; Sarathchandra, Padmini; Germack, Renee; Rosenthal, Nadia; Santini, Maria Paola

    2011-01-01

    Highlights: ► In this study, we explored the function of IGF-1Ea propeptide in inducing cardiogenesis of stem cells. ► IGF-1Ea promoted cardiac mesodermal induction in uncommitted cells. ► Under differentiation condition, IGF-1Ea increased expression of cardiac differentiation markers. ► Furthermore, it promoted formation of finely organized sarcomeric structure. ► IGF-1Ea propeptide may be a good candidate to improve production of cardiomyocytes from pluripotent cells. -- Abstract: The mechanism implicated in differentiation of endogenous cardiac stem cells into cardiomyocytes to regenerate the heart tissue upon an insult remains elusive, limiting the therapeutical goals to exogenous cell injection and/or gene therapy. We have shown previously that cardiac specific overexpression of the insulin-like growth factor 1 propeptide IGF-1Ea induces beneficial myocardial repair after infarct. Although the mechanism is still under investigation, the possibility that this propeptide may be involved in promoting stem cell differentiation into the cardiac lineage has yet to be explored. To investigate whether IGF-1Ea promote cardiogenesis, we initially modified P19 embryonal carcinoma cells to express IGF-1Ea. Taking advantage of their cardiomyogenic nature, we analyzed whether overexpression of this propeptide affected cardiac differentiation program. The data herein presented showed for the first time that constitutively overexpressed IGF-1Ea increased cardiogenic differentiation program in both undifferentiated and DMSO-differentiated cells. In details, IGF-1Ea overexpression promoted localization of alpha-actinin in finely organized sarcomeric structure compared to control cells and upregulated the cardiac mesodermal marker NKX-2.5 and the ventricular structural protein MLC2v. Furthermore, activated IGF-1 signaling promoted cardiac mesodermal induction in undifferentiated cells independently of cell proliferation. This analysis suggests that IGF-1Ea may be a

  1. 47 CFR 11.32 - EAS Encoder.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EMERGENCY ALERT SYSTEM (EAS) Equipment Requirements § 11... operation. (vi) Indicator Display. The encoder shall be provided with a visual and/or aural indicator which... to +50 degrees C and a range of relative humidity of up to 95%. (c) Primary Supply Voltage Variation...

  2. Digitaalisen markkinointiviestinnän mahdollisuudet : Case Kelloliike EA Lahti Oy

    OpenAIRE

    Harmaala, Tiina

    2011-01-01

    TIIVISTELMÄ Harmaala, Tiina. 2011. Digitaalisen markkinointiviestinnän mahdollisuudet – Case Kelloliike EA Lahti Oy. Opinnäytetyö. Kemi-Tornion ammattikorkeakoulu. Kaupan ja kulttuurin toimiala. Sivuja 62. Opinnäytetyön tavoitteena on Kelloliike EA Lahti Oy:n digitaalisen markkinointiviestinnän suunnittelu. Tutkimuksessa tarkastelen digitaalista markkinointiviestintää integroidun markkinointiviestinnän näkökulmasta. Tutkimuksen tarkoituksena on selvittää toimeksiantajalle sen markkino...

  3. E+A galaxies in the SDSS. Stellar population and morphology

    Science.gov (United States)

    Leiva, R.; Galaz, G.

    2014-10-01

    Galaxies with E+A spectrum have deep Balmer absorption and no H_{α} and [OII] emission. This suggest recent star formation and the lack of ongoing star formation. With an E+A sample from the SDSS DR 7 (Aihara et al. 2011) we study the morphology with Galaxy Zoo 1 data and the star formation history fitting models from Bruzual & Charlot (2003). We found an underpopulation of spiral and disk like galaxies and an overpopulation of interacting galaxies, the last seems consistent with the scenario where, at low z, the interaction mechanism is responsible for at least part of the E+A galaxies. The star formation history (SFH) fits most of the spectra indicating an increased star formation around 2 Gyr in the past. Additional parameters like dust internal extinction need to be included to improve the fitting.

  4. Development of longitudinally excited CO2 laser

    Science.gov (United States)

    Masroon, N. S.; Tanaka, M.; Tei, M.; Uno, K.; Tsuyama, M.; Nakano, H.

    2018-05-01

    Simple, compact, and affordable discharged-pumped CO2 laser controlled by a fast high voltage solid state switch has been developed. In this study, longitudinal excitation scheme has been adapted for simple configuration. In the longitudinal excitation scheme, the discharge is produced along the direction of the laser axis, and the electrodes are well separated with a small discharge cross-section. Triggered spark gap switch is usually used to switch out the high voltage because of simple and low cost. However, the triggered spark gap operates in the arc mode and suffer from recovery problem causing a short life time and low efficiency for high repetition rate operation. As a result, there is now considerable interest in replacing triggered spark gap switch with solid state switches. Solid state switches have significant advantages compared to triggered spark gap switch which include longer service lifetime, low cost and stable high trigger pulse. We have developed simple and low cost fast high voltage solid state switch that consists of series connected-MOSFETs. It has been installed to the longitudinally excited CO2 laser to realize the gap switch less operation. Characteristics of laser oscillation by varying the discharge length, charging voltage, capacitance and gas pressure have been evaluated. Longer discharge length produce high power of laser oscillation. Optimum charging voltage and gas pressure were existed for longitudinally excited CO2 laser.

  5. Environmental Agents Service (EAS) Registry System of Records

    Data.gov (United States)

    Department of Veterans Affairs — The Environmental Agent Service (EAS) Registries is the information system encompassing the Ionizing Radiation Registry (IRR), the Agent Orange Registry (AOR), and...

  6. 7 CFR 1955.136 - Environmental Assessment (EA) and Environmental Impact Statement (EIS).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Environmental Assessment (EA) and Environmental Impact... Disposal of Inventory Property General § 1955.136 Environmental Assessment (EA) and Environmental Impact Statement (EIS). (a) Prior to a final decision on some disposal actions, an environmental assessment must be...

  7. Self-Adaptive Operator Scheduling using the Religion-Based EA

    DEFF Research Database (Denmark)

    Thomsen, Rene; Krink, Thiemo

    2002-01-01

    of their application is determined by a constant parameter, such as a fixed mutation rate. However, recent studies have shown that the optimal usage of a variation operator changes during the EA run. In this study, we combined the idea of self-adaptive mutation operator scheduling with the Religion-Based EA (RBEA......), which is an agent model with spatially structured and variable sized subpopulations (religions). In our new model (OSRBEA), we used a selection of different operators, such that each operator type was applied within one specific subpopulation only. Our results indicate that the optimal choice...

  8. Measurable difference in Cherenkov light between gamma and hadron induced EAS

    Energy Technology Data Exchange (ETDEWEB)

    Cabot, H.; Meynadier, Ch. [Universite de Perpignan, Groupe de Physique Fondamentale, Perpignan (France); Sobczynska, D. [Experimental Physics Department, University of Lodz, Lodz (Poland); Szabelska, B. [Soltan Institute for Nuclear Studies, Lodz (Poland); Szabelski, J. [Universite de Perpignan, Groupe de Physique Fondamentale, Perpignan (France)]|[Soltan Institute for Nuclear Studies, Lodz (Poland); Wibig, T. [Experimental Physics Department, University of Lodz, Lodz (Poland)

    1997-12-31

    We describe the possibly measurable difference in the Cherenkov light component of EAS induced by en electromagnetic particle (i.e. e{sup +}, e{sup -} or {gamma}) and induced by a hadron (i.e. proton or heavier nuclei) in TeV range. The method can be applied in experiments which use wavefront sampling method of EAS Cherenkov light detection (e.g. THEMISTOCLE, ASGAT). (author) 16 refs, 9 figs

  9. D2.1 - An EA Active, Problem Based Learning Methodology - EAtrain2

    DEFF Research Database (Denmark)

    Ryberg, Thomas; Georgsen, Marianne; Buus, Lillian

    This deliverable reports on the work undertaken in work package 2 with the key objective to develop a learning methodology for web 2.0 mediated Enterprise Architecture (EA) learning building on a problem based learning (PBL) approach. The deliverable reports not only on the methodology but also...... on the activities leading to its development (literature review, workshops, etc.) and on further outcomes of this work relevant to the platform specification and pilot courses preparation....

  10. Runtime analysis of the (1+1) EA on computing unique input output sequences

    DEFF Research Database (Denmark)

    Lehre, Per Kristian; Yao, Xin

    2010-01-01

    Computing unique input output (UIO) sequences is a fundamental and hard problem in conformance testing of finite state machines (FSM). Previous experimental research has shown that evolutionary algorithms (EAs) can be applied successfully to find UIOs for some FSMs. However, before EAs can...... in the theoretical analysis, and the variability of the runtime. The numerical results fit well with the theoretical results, even for small problem instance sizes. Together, these results provide a first theoretical characterisation of the potential and limitations of the (1 + 1) EA on the problem of computing UIOs....

  11. EAS selection in the EMMA underground array

    DEFF Research Database (Denmark)

    Sarkamo, J.; Bezrukov, L.; Enqvist, T.

    2013-01-01

    The first measurements of the Experiment with MultiMuon Array (EMMA) have been analyzed for the selection of the Extensive Air Showers (EAS). Test data were recorded with an underground muon tracking station and a satellite station separated laterally by 10 metres. Events with tracks distributed...

  12. CASA-MIA: A ''precision'' EAS detector

    International Nuclear Information System (INIS)

    Borione, A.; Cronin, J.W.; Covault, C.E.; Fick, B.E.; Gibbs, K.G.; Krimm, H.A.; McKay, T.A.; Mueller, D.; Newport, B.J.; Ong, R.A.; Rosenberg, L.J.; Catanese, M.; Green, K.D.; Matthews, J.; Nitz, D.F.; Sinclair, D.; van der Velde, J.C.; Kieda, D.

    1993-01-01

    The CASA-MIA detector was constructed to search for sources of UHE neutral radiation. As such it has established limits well below those of previously reported observations and of most contemporaneous detectors. In addition to its primary mission, however, CASA-MIA measures the lateral distribution of both electrons and muons in EAS throughout a range of energies and with a degree of sampling not previously available

  13. Optimal mutation rates for the (1+λ) EA on OneMax

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2016-01-01

    We study the (1 + λ) EA with mutation probability c/n, where c > 0 is a constant, on the ONEMAX problem. Using an improved variable drift theorem, we show that upper and lower bounds on the expected runtime of the (1+λ) EA obtained from variable drift theorems are at most apart by a small lower...... mutation rates for the (1+λ) EA for various parameter settings of c and λ and also for moderate sizes of n. This makes the need for potentially lengthy and costly experiments in order to optimize the parameters unnecessary. Interestingly, even for moderate n and not too small λ it turns out that mutation...... rates up to 10% larger than the asymptotically optimal rate 1/n minimize the expected runtime. However, in absolute terms the expected runtime does not change by much when replacing 1/n with the optimal mutation rate....

  14. Longitudinal trends in climate drive flowering time clines in North American Arabidopsis thaliana.

    Science.gov (United States)

    Samis, Karen E; Murren, Courtney J; Bossdorf, Oliver; Donohue, Kathleen; Fenster, Charles B; Malmberg, Russell L; Purugganan, Michael D; Stinchcombe, John R

    2012-06-01

    Introduced species frequently show geographic differentiation, and when differentiation mirrors the ancestral range, it is often taken as evidence of adaptive evolution. The mouse-ear cress (Arabidopsis thaliana) was introduced to North America from Eurasia 150-200 years ago, providing an opportunity to study parallel adaptation in a genetic model organism. Here, we test for clinal variation in flowering time using 199 North American (NA) accessions of A. thaliana, and evaluate the contributions of major flowering time genes FRI, FLC, and PHYC as well as potential ecological mechanisms underlying differentiation. We find evidence for substantial within population genetic variation in quantitative traits and flowering time, and putatively adaptive longitudinal differentiation, despite low levels of variation at FRI, FLC, and PHYC and genome-wide reductions in population structure relative to Eurasian (EA) samples. The observed longitudinal cline in flowering time in North America is parallel to an EA cline, robust to the effects of population structure, and associated with geographic variation in winter precipitation and temperature. We detected major effects of FRI on quantitative traits associated with reproductive fitness, although the haplotype associated with higher fitness remains rare in North America. Collectively, our results suggest the evolution of parallel flowering time clines through novel genetic mechanisms.

  15. Burnout development among dentists : a longitudinal study

    NARCIS (Netherlands)

    te Brake, H.; Smits, N.; Wicherts, J.M.; Gorter, R.C.; Hoogstraten, J.

    2008-01-01

    Knowledge on the development of burnout among dentists is important for purposes of prevention and intervention. Using a two-wave longitudinal design, this study examined the chronological sequence of the three dimensions of the Maslach Burnout Inventory: emotional exhaustion; depersonalization; and

  16. The Stellar Kinematics of E+A Galaxies in SDSS IV-MaNGA

    Science.gov (United States)

    Johnson, Amalya; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Kerrison, Nicole; Marinelli, Mariarosa; Melchert, Nancy; Ojanen, Winonah; Liu, Charles; SDSS-IV MaNGA

    2018-01-01

    E+A galaxies, hypothesized to be “transition” galaxies between the blue cloud and the red sequence, are valuable sources for studying the evolution of galaxies. Using data from the Sloan Digital Sky Survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, a large scale integral field spectroscopic survey of nearby galaxies from 3600 to 10300 Å, we identifed galaxies that exhibitted E+A characteristics within their optical spectra. We analyzed the 2,812 galaxies thus far observed by MaNGA to identify those that showed evidence of a starburst about 1 billion years ago, followed by cessation of star formation and quenching of the galaxy. Through this process we identifed 39 E+A galaxies by directly looking at the optical spectra and ensuring they exhibited the necessary properties of an E+A spectra, including a strong break at the 4000 Å mark, little to no Hα emission and absorption through the Balmer series, and a blue slope of the continuum past ~5000 Å as the flux decreases. We analyzed the stellar kinematics of these galaxies to determine whether or not they were fast or slow rotators, a proposed indicator of a major merger in their recent past. Using Voronoi binned graphs from the MaNGA Marvin database, we measured their stellar rotation curves in order to more clearly show the range of velocities within the galaxies. Among our 39 E+A candidates, all but two exhibited significant, orderly rotation across the galaxy, and 29 out of 39 of our galaxies show rotation faster than 30 km/s. With the caveat that our selection process was biased toward galaxies with orderly rotation, this prevalence of rotation challenges the belief that all E+A galaxies are created from major mergers. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  17. Electron attachment rate constant measurement by photoemission electron attachment ion mobility spectrometry (PE-EA-IMS)

    International Nuclear Information System (INIS)

    Su, Desheng; Niu, Wenqi; Liu, Sheng; Shen, Chengyin; Huang, Chaoqun; Wang, Hongmei; Jiang, Haihe; Chu, Yannan

    2012-01-01

    Photoemission electron attachment ion mobility spectrometry (PE-EA-IMS), with a source of photoelectrons induced by vacuum ultraviolet radiation on a metal surface, has been developed to study electron attachment reaction at atmospheric pressure using nitrogen as the buffer gas. Based on the negative ion mobility spectra, the rate constants for electron attachment to tetrachloromethane and chloroform were measured at ambient temperature as a function of the average electron energy in the range from 0.29 to 0.96 eV. The experimental results are in good agreement with the data reported in the literature. - Highlights: ► Photoemission electron attachment ion mobility spectrometry (PE-EA-IMS) was developed to study electron attachment reaction. ► The rate constants of electron attachment to CCl 4 and CHCl 3 were determined. ► The present experimental results are in good agreement with the previously reported data.

  18. The genome of the Erwinia amylovora phage PhiEaH1 reveals greater diversity and broadens the applicability of phages for the treatment of fire blight.

    Science.gov (United States)

    Meczker, Katalin; Dömötör, Dóra; Vass, János; Rákhely, Gábor; Schneider, György; Kovács, Tamás

    2014-01-01

    The enterobacterium Erwinia amylovora is the causal agent of fire blight. This study presents the analysis of the complete genome of phage PhiEaH1, isolated from the soil surrounding an E. amylovora-infected apple tree in Hungary. Its genome is 218 kb in size, containing 244 ORFs. PhiEaH1 is the second E. amylovora infecting phage from the Siphoviridae family whose complete genome sequence was determined. Beside PhiEaH2, PhiEaH1 is the other active component of Erwiphage, the first bacteriophage-based pesticide on the market against E. amylovora. Comparative genome analysis in this study has revealed that PhiEaH1 not only differs from the 10 formerly sequenced E. amylovora bacteriophages belonging to other phage families, but also from PhiEaH2. Sequencing of more Siphoviridae phage genomes might reveal further diversity, providing opportunities for the development of even more effective biological control agents, phage cocktails against Erwinia fire blight disease of commercial fruit crops.

  19. Spectrophotometric Properties of E+A Galaxies in SDSS-IV MaNGA

    Science.gov (United States)

    Marinelli, Mariarosa; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Johnson, Amalya; Kerrison, Nicole; Melchert, Nancy; Ojanen, Winonah; Weaver, Olivia; Liu, Charles; SDSS-IV MaNGA

    2018-01-01

    Quenched post-starburst galaxies, or E+A galaxies, represent a unique and informative phase in the evolution of galaxies. We used a qualitative rubric-based methodology, informed by the literature, to manually select galaxies from the SDSS-IV IFU survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) using the single-fiber spectra from the Sloan Digital Sky Survey Data Release 8. Of the 2,812 galaxies observed so far in MaNGA, we found 39 galaxies meeting our criteria for E+A classification. Spectral energy distributions of these 39 galaxies from the far-UV to the mid-infrared demonstrate a heterogeneity in our sample emerging in the infrared, indicating many distinct paths to visually similar optical spectra. We used SDSS-IV MaNGA Pipe3D data products to analyze stellar population ages, and found that 34 galaxies exhibited stellar populations that were older at 1 effective radius than at the center of the galaxy. Given that our sample was manually chosen based on E+A markers in the single-fiber spectra aimed at the center of each galaxy, our E+A galaxies may have only experienced their significant starbursts in the central region, with a disk of quenched or quenching material further outward. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  20. Adolescent psychosocial development: A review of longitudinal models and research.

    Science.gov (United States)

    Meeus, Wim

    2016-12-01

    This review used 4 types of longitudinal models (descriptive models, prediction models, developmental sequence models and longitudinal mediation models) to identify regular patterns of psychosocial development in adolescence. Eight patterns of adolescent development were observed across countries: (1) adolescent maturation in multiple developmental domains; (2) heterogeneous continuity of personal relationships; (3) good goes together with good, and bad with bad, across time in adolescence; (4) parents transmit values and behaviors to their adolescent children over time; (5) adolescent psychopathology leads to erosion of personal relationships with parents and peers; (6) adolescent psychopathology prevents adolescent independence from parents; (7) parental interference in personal issues of adolescents has counterproductive effects over time; (8) mood variability and (social and personal) uncertainty are mechanisms that maintain psychopathology in adolescence. Principles of life span developmental psychology are used to discuss adolescent maturation, and a developmental contextual perspective is used to discuss links between the various developmental patterns. Strengths and limitations of the various longitudinal models, and links between longitudinal and experimental research are discussed. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  1. Investigation of relative arrival time distributions of EAS electron and muon component with the KASCADE central detector

    International Nuclear Information System (INIS)

    Hafemann, W.; Haeusler, R.; Rebel, H.; Mathes, H.J.

    2000-01-01

    The central detector of the KASCADE experiment is equipped with two layers of scintillation detectors with different area coverage. The scintillators of both detector systems have a good timing resolution of about 1.6 ns. With these two arrangements we performed extensive measurements of the arrival time differences at different energy thresholds of the electron and the muon component of EAS. The observed time structure of the shower profile is classified according to different EAS parameters. We furthermore present an analysis and comparism based on detailed MC simulations of the shower development. This comparism shows good agreement between experimental data and the expected behaviour of the different time distributions. (orig.)

  2. 47 CFR 1.1311 - Environmental information to be included in the environmental assessment (EA).

    Science.gov (United States)

    2010-10-01

    ... a residential area, the EA must also address the impact of this lighting upon the residents. (2) A... concerning the proposal's environmental impact, if any. The EA shall deal specifically with any feature of... land utilized (e.g., deforestation, water diversion, wetland fill, or other extensive change of surface...

  3. The Czech longitudinal study of optimal development

    Czech Academy of Sciences Publication Activity Database

    Kebza, V.; Šolcová, Iva; Kodl, M.; Kernová, V.

    2012-01-01

    Roč. 47, Suppl. 1 (2012), s. 266-266 ISSN 0020-7594. [International Congress of Psychology /30./. 22.07.2012-27.07.2012, Cape Town] R&D Projects: GA ČR GAP407/10/2410 Institutional support: RVO:68081740 Keywords : optimal development * Prague longitudinal study Subject RIV: AN - Psychology

  4. Enrichment of Microbial Cultures for Hydrolysis of EA2192

    National Research Council Canada - National Science Library

    Rastogi, Vipin

    1998-01-01

    .... The enrichment was initiated using consortium adapted to biodegrade hydrolyzed vx (courtesy Dr. DeFrank). Based on NMR analysis, the concentration of EA2192 reduced from 120 ppm to 50 ppm in 48 hr of growth...

  5. [A sporadic case of episodic ataxia with nystagmus (EA-2)].

    Science.gov (United States)

    Namekawa, M; Takiyama, Y; Ueno, N; Nishizawa, M

    1998-05-01

    A 39-year-old man with episodic ataxia with nystagmus (EA-2) was reported. He showed intermittent cerebellar dysfunction, i.e., ataxia, nystagmus, dysarthria and vertigo, since he was 10 years old. Although this attack lasted for several hours, he was normal with exception of interictal nystagmus. His parents and sister showed no episodic ataxia. We ruled out the diseases, which may cause episodic ataxia, such as multiple sclerosis, vascular disorders, metabolic disorders and congenital anomalies. He was released from the attack by treatment with acetazolamide. EA-2 has been associated with mutations in the alpha 1A-voltage dependent calcium channel gene (CACNL1A4), which is also affected in familial hemiplegic migraine (FMH) and spinocerebellar ataxia type 6 (SCA6). In EA-2, frame-shift mutation leading to premature stop and splice-site mutation leading to truncated, non-functional channel protein have been reported. However, our patient did not have the mutations in the CACNL1A4 gene that were previously reported. In addition, our patient did not have an expanded CAG allele in the CACNL1A4 gene which is responsible for SCA6. Further examination is required to address whether a new mutation exists in the CACNL1A4 gene in our patient.

  6. A Combined group EA-PROMETHEE method for a supplier selection problem

    Directory of Open Access Journals (Sweden)

    Hamid Reza Rezaee Kelidbari

    2016-07-01

    Full Text Available One of the important decisions which impacts all firms’ activities is the supplier selection problem. Since the 1950s, several works have addressed this problem by treating different aspects and instances. In this paper, a combined multiple criteria decision making (MCDM technique (EA-PROMETHEE has been applied to implement a proper decision making. To this aim, after reviewing the theoretical background regarding to supplier selection, the extension analysis (EA is used to determine the importance of criteria and PROMETHEE for appraisal of suppliers based on the criteria. An empirical example illustrated the proposed approach.

  7. Time for a new approach to public participation in EA: Promoting cooperation and consensus for sustainability

    International Nuclear Information System (INIS)

    Doelle, Meinhard; Sinclair, A. John

    2006-01-01

    One of the fundamental challenges of project-based environmental assessments (EA) has been to deliver on the promise of meaningful public participation leading to decisions that put affected societies on the path to sustainability. The record to date has been less than promising, leading the authors to propose that it is time to consider a different approach to legislating public participation in project assessments, one that starts with the ultimate objective of cooperation and consensus building. The authors work back from this objective and propose an EA process specifically designed to encourage all participants to participate constructively. In the process, the authors identify how the proposed process will address various criticisms made of the traditional approach to EA by proponents, government officials and members of the public alike. Through a fundamental shift from process requirements to a focus on the outcomes of EA, the authors propose a way forward for project-based EA to deliver on the promise of becoming a central tool on the path to sustainability

  8. A New Kind of Void Soap-free P(MMA-EA-MAA) Latex Particles

    Institute of Scientific and Technical Information of China (English)

    Kai KANG; Cheng You KAN; Yi DU; Yu Zhong LI; De Shan LIU

    2005-01-01

    Soap-free P(MMA-EA-MAA) particles with narrow size distribution were synthesized by seeded emulsion polymerization of methyl methacrylate (MMA), ethyl acrylate (EA) and methacrylic acid (MAA), and large voids inside the particles were generated by alkali posttreatment in the presence of 2-butanone. Results indicated that the size of void and the particle volume were related with the amount of 2-butanone. The generation mechanism of voids was proposed.

  9. Post-Starburst Galaxies At The End of The E+A Phase

    Science.gov (United States)

    Liu, Charles; Marinelli, Mariarosa; Chang, Madeleine; Lyczko, Camilla; Vega Orozco, Cecilia; SDSS-IV Collaboration

    2018-06-01

    Post-starburst galaxies, once thought to be rare curiosities, are now recognized to represent a key phase in the galaxy evolution. The post-starburst, or E+A phase, should however not be considered as a single, short-lived phenomenon; rather, it is an extended evolutionary process that occurs a galaxy transitions from an actively star-forming system into a quiescent one. We present a study of nearby galaxies at or near the end of the E+A phase, wherein all star formation has been quenched, the fossilized stellar population of the most recent starburst is highly localized, and the remainder of the galaxy's stellar population is old and quiescent. The luminosity and stellar age distribution of these "end-phase E+As" can provide insights into the evolution of galaxies onto and within the red sequence, from active to passive systems. This work is supported by National Science Foundation grants to CUNY College of Staten Island and the American Museum of Natural History; the College of Staten Island Office of Academic Affairs; the Sherman Fairchild Science Pathways Scholars Program (SP^2) at Barnard College; and the Alfred P. Sloan Foundation.

  10. Developing a longitudinal cancer nursing education program in Honduras.

    Science.gov (United States)

    Sheldon, Lisa Kennedy; Wise, Barbara; Carlson, Julie R; Dowds, Cynthia; Sarchet, Vanessa; Sanchez, Jose Angel

    2013-12-01

    The present paper is a longitudinal study which aims to develop and deliver cancer nursing education conferences in Honduras using volunteer nurse educators. This program intends to (1) perform site assessments of work environments and resources for cancer care in Honduras, (2) develop cancer nursing education programs, (3) survey conference participants continuing education needs, (4) deliver cancer nursing education conferences, and (5) share data with local and global partners for future cancer programs. The study draws on a longitudinal program development with site assessments, data collection, and educational conferences at two time points. Assessments and surveys were used for conference development and delivery by volunteer nurse educators. Site assessments and conferences were delivered twice. Data were collected regarding assessments and surveys to inform program development. Survey data revealed that 65 % had internet access. Participants desired more information about handling of chemotherapy, symptom management, and palliative care. Volunteer nurse educators perform site assessments and develop educational programming for cancer nurses. Local and global partners should explore internet-based programs between site visits to create sustainable education programs.

  11. Trends in Governmental Enterprise Architecture: Reviewing National EA Programs

    DEFF Research Database (Denmark)

    Gøtze, John; Christiansen, Peter Engelund

    2007-01-01

    This article is the first in a series of three, where we will analyze and evaluate governmental enterprise architecture policies and practices from an international perspective. This first article presents the overall findings from an international study, we have made about governmental EA, and i...

  12. Inclusive pseudodata for eA collisions at the LHeC

    CERN Document Server

    Armesto, N

    2010-01-01

    I explain how the pseudodata for eA collisions are generated, for the reduced cross section, $F_2$, $F_L$ and the corresponding heavy flavor decompositions. I also discuss how the uncertainties are computed.

  13. EAS vahendas mullu Harjumaale 47 miljonit krooni toetusi / Allar Korjas

    Index Scriptorium Estoniae

    Korjas, Allar

    2005-01-01

    Möödunud aastal jõudis EAS- i vahendusel alustavate ja tegutsevate ettevõtete ning regionaalse arengu toetamiseks Harjumaale 47,1 miljonit krooni. Tabel. Vt. samas: Aare Ets. Regionaalne koostöö Harjumaal on oluline

  14. Development of a longitudinal feedback cavity for the beam feedback system

    International Nuclear Information System (INIS)

    Huang Gang; Chen Huaibi; Huang Wenhui; Tong Dechun; Lin Yuzheng; Zhao Zhentang

    2003-01-01

    Longitudinal beam feedback system is widely used to damp coupling bunch instability. Kicker is one of the key components of the longitudinal feedback system. A prototype cavity of longitudinal feedback kicker is developed according to the parameter of BEPC II. The usage of nose cone in the kicker design increased the shunt impedance. In order to avoid the extra tapper in the storage ring, the racetrack shape beam pipe is applied in the kicker. The impedance and the bandwidth of the kicker is measured by the coaxial line impedance measurement platform and the result achieved the design goals

  15. MODELING AND DESIGN STUDY USING HFC-236EA AS AN ALTERNATIVE REFRIGERANT IN A CENTRIFUGAL COMPRESSOR

    Science.gov (United States)

    The report gives results of an investigation of the operation of a centrifugal compressor--part of a chlorofluorocarbon (CFC)-114 chiller installation--with the new refrigerant hydrofluorocarbon (HFC)-236ea, a proposed alternative to CFC-114. A large set of CFC-236ea operating da...

  16. Longitudinal changes in cortical thickness in autism and typical development.

    Science.gov (United States)

    Zielinski, Brandon A; Prigge, Molly B D; Nielsen, Jared A; Froehlich, Alyson L; Abildskov, Tracy J; Anderson, Jeffrey S; Fletcher, P Thomas; Zygmunt, Kristen M; Travers, Brittany G; Lange, Nicholas; Alexander, Andrew L; Bigler, Erin D; Lainhart, Janet E

    2014-06-01

    The natural history of brain growth in autism spectrum disorders remains unclear. Cross-sectional studies have identified regional abnormalities in brain volume and cortical thickness in autism, although substantial discrepancies have been reported. Preliminary longitudinal studies using two time points and small samples have identified specific regional differences in cortical thickness in the disorder. To clarify age-related trajectories of cortical development, we examined longitudinal changes in cortical thickness within a large mixed cross-sectional and longitudinal sample of autistic subjects and age- and gender-matched typically developing controls. Three hundred and forty-five magnetic resonance imaging scans were examined from 97 males with autism (mean age = 16.8 years; range 3-36 years) and 60 males with typical development (mean age = 18 years; range 4-39 years), with an average interscan interval of 2.6 years. FreeSurfer image analysis software was used to parcellate the cortex into 34 regions of interest per hemisphere and to calculate mean cortical thickness for each region. Longitudinal linear mixed effects models were used to further characterize these findings and identify regions with between-group differences in longitudinal age-related trajectories. Using mean age at time of first scan as a reference (15 years), differences were observed in bilateral inferior frontal gyrus, pars opercularis and pars triangularis, right caudal middle frontal and left rostral middle frontal regions, and left frontal pole. However, group differences in cortical thickness varied by developmental stage, and were influenced by IQ. Differences in age-related trajectories emerged in bilateral parietal and occipital regions (postcentral gyrus, cuneus, lingual gyrus, pericalcarine cortex), left frontal regions (pars opercularis, rostral middle frontal and frontal pole), left supramarginal gyrus, and right transverse temporal gyrus, superior parietal lobule, and

  17. Search for Anti-EA(D Antibodies in Subjects with an “Isolated VCA IgG” Pattern

    Directory of Open Access Journals (Sweden)

    Massimo De Paschale

    2010-01-01

    Full Text Available The presence of an “isolated viral capsid antigen (VCA IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. However, one alternative is to use an enzyme-linked immunosorbent assay (ELISA to detect anti-early antigen (EA antibodies, which can be found in about 85% of subjects with acute Epstein-Barr virus (EBV infections. The purpose of this work was to search for anti-EA(D antibodies in 130 samples with an isolated VCA IgG pattern at ELISA screening and classified as being indicative of past (102 cases or acute (28 cases infection on the basis of the immunoblotting results. Thirty-seven samples (28.5% were positive for anti-EA(D, of which 25 (89.3% had been classified by immunoblotting as indicating acute and 12 (11.8% past EBV infection. This difference was statistically significant (<.01. The results of our search for anti-EA(D antibodies correctly identified nearly 90% of acute (presence or past EBV infections (absence. When other tests are not available, the search for anti-EA antibodies may therefore be helpful in diagnosing patients with an isolated VCA IgG pattern at screening tests.

  18. Preequilibrium light particle emission in heavy ion collisions for E/A between 10 and 20 MeV/A

    International Nuclear Information System (INIS)

    Kailas, S.

    1989-01-01

    It is known that when two heavy ions collide, while the interaction process is dominated by nucleus-nucleus mean field effects at lower energies (E/A < 10Me V), the nucleon-nucleon collision aspects dominate at higher energies (E/A <100 MeV) . In the intermediate E/A region, both the above mentioned effects are important t o varying degrees. Many experiments have shown that when the incident energy excee ds 10 MeV/A, the complete fusion (CF) of target and projectile gives way to an inco mplete fusion (ICF) mechanism associated with preequilibrium light particle (PELP) emmi sion. This phenomenon becomes increasingly important as E increases and at E/A < 20 Me V, the cross section for PELP emission becomes comparable to the reaction cross section . Considerable progress has been made in the last decade towards understanding of ICF and PELP. In the present work, the review of this field is mainly restricted to E/A values lying between 10 and 20 MeV/A. (author). 27 refs., 5 figs

  19. Separation and properties of EA-rosette-forming lymphocytes in humans

    NARCIS (Netherlands)

    van Oers, M. H.; Zeijlemaker, W. P.; Schellekens, P. T.

    1977-01-01

    Human peripheral blood lymphocytes were separated into subpopulations enriched or depleted with respect to B lymphocytes (Ig-bearing cells), T lymphocytes, (cell forming rosettes with sheep erythrocytes: E-RFC) and Fc receptor-bearing lymphocytes (EA-RFC). From the distributions and recoveries of

  20. ACC/AHA guidelines superior to ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans

    DEFF Research Database (Denmark)

    Mortensen, Martin Bødtker; Nordestgaard, Børge G; Afzal, Shoaib

    2017-01-01

    Aim We compared the 2013 American College of Cardiology/American Heart Association (ACC/AHA) and the 2016 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on prevention of atherosclerotic cardiovascular disease (ASCVD) using different risk prediction models [US......-calibrated around decision thresholds for statin therapy. For a Class I recommendation, 42% of individuals qualified for statins using the ACC/AHA guidelines vs. 6% with the ESC/EAS guidelines. Using ACC/AHA- vs. ESC/EAS-defined statin eligibility led to a substantial gain in sensitivity (+62% for any ASCVD and+76......% for fatal ASCVD) with a smaller loss in specificity (-35% for any ASCVD and -36% for fatal ASCVD). Similar differences between the ACC/AHA and ESC/EAS guidelines were found for men and women separately, and for Class IIa recommendations. The sensitivity and specificity of a US-PCE risk of 5% were similar...

  1. 75 FR 62133 - Notice of Availability of Final Environmental Assessment (FINAL EA) and a Finding of No...

    Science.gov (United States)

    2010-10-07

    ... Availability of Final Environmental Assessment (FINAL EA) and a Finding of No Significant Impact (FONSI) for... of No Significant Impact (FONSI) for Land Purchase, Access Road Construction and Access Tunnel... Impact (FONSI) based on the Final Environmental Assessment (FINAL EA) for Land Purchase, Access Road...

  2. Membrane topology and identification of key residues of EaDAcT, a plant MBOAT with unusual substrate specificity.

    Science.gov (United States)

    Tran, Tam N T; Shelton, Jennifer; Brown, Susan; Durrett, Timothy P

    2017-10-01

    Euonymus alatus diacylglycerol acetyltransferase (EaDAcT) catalyzes the transfer of an acetyl group from acetyl-CoA to the sn-3 position of diacylglycerol to form 3-acetyl-1,2-diacyl-sn-glycerol (acetyl-TAG). EaDAcT belongs to a small, plant-specific subfamily of the membrane bound O-acyltransferases (MBOAT) that acylate different lipid substrates. Sucrose gradient density centrifugation revealed that EaDAcT colocalizes to the same fractions as an endoplasmic reticulum (ER)-specific marker. By mapping the membrane topology of EaDAcT, we obtained an experimentally determined topology model for a plant MBOAT. The EaDAcT model contains four transmembrane domains (TMDs), with both the N- and C-termini orientated toward the lumen of the ER. In addition, there is a large cytoplasmic loop between the first and second TMDs, with the MBOAT signature region of the protein embedded in the third TMD close to the interface between the membrane and the cytoplasm. During topology mapping, we discovered two cysteine residues (C187 and C293) located on opposite sides of the membrane that are important for enzyme activity. In order to identify additional amino acid residues important for acetyltransferase activity, we isolated and characterized acetyltransferases from other acetyl-TAG-producing plants. Among them, the acetyltransferase from Euonymus fortunei possessed the highest activity in vivo and in vitro. Mutagenesis of conserved amino acids revealed that S253, H257, D258 and V263 are essential for EaDAcT activity. Alteration of residues unique to the acetyltransferases did not alter the unique acyl donor specificity of EaDAcT, suggesting that multiple amino acids are important for substrate recognition. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  3. Projectile-like fragments from 129Xe+natCu reactions at E/A = 40 MeV

    International Nuclear Information System (INIS)

    Russ, D.E.; Mignerey, A.C.; Garcia-Solis, E.J.

    1996-01-01

    The bombarding of heavy nuclei with energetic heavy projectiles has been one of the most important experimental tools for nuclear science. At low beam energies, (E/A) beam 100 MeV, these mean field effects are less important and nucleon-nucleon interactions dominate. Within the intermediate energy region, the situation is less clear because of both the mean field and nucleon-nucleon effects contribute. There is no consensus on the theoretical treatment of nuclear reaction in the intermediate energy regime and statistical, dynamical, and hybrid models have been used with limited success. Previous studies of 136 Xe + 209 Bi at E/A = 28 MeV carried out at Michigan State University (MSU) have been well described by a damped reaction mechanism. On the other hand, 129 Xe + nat Cu at E/A = 50 MeV also at MSU has been compared with a hybrid model with reasonable success. In order to see a transition from a damped reaction mechanism to more fragmentation-like processes, an experiment was carried out at MSU using 129 Xe beams at E/A = 30, 40, 50, and 60 MeV. The targets were Cu, Sc, and Au. The current study only looks at the projectile-like fragments (PLF) detected in the Maryland Forward Array (MFA)

  4. Effects of the foliar-applied protein "Harpin(Ea)" (messenger) on tomatoes infected with Phytophthora infestans.

    Science.gov (United States)

    Fontanilla, M; Montes, M; De Prado, R

    2005-01-01

    The active ingredient in Messenger, is Harpin(Ea), a naturally occurring protein derived from Erwinia amylovora, a causal agent of fire blight. When Messenger is applied to a plant, the protein Harpin(Ea) binds foliar receptors to it. The receptors recognize the presence of Harpin(Ea), sending a signal that a pathogen is present, actually "tricking" the plant into thinking that it is under attack. This binding process triggers a cascade of responses affecting a global change of gene expressions, stimulating several distinct biochemical pathways within the plant responsible for growth and disease and insect resistance. The objective of this work is to characterize the development of an induced resistance against Phytophthora infestans. No effective treatment is currently available against this pathogenic agent, which causes the loss of complete harvests of different crops. Tomato plants with and without Messenger applications were inoculated with Phytophthora infestans in the same way. In addition, some plants with and without Messenger applications were not inoculated. Inoculated plants were symptomatologically checked for local and systemic symptoms. Evaluations of the number of tomatoes produced, with or without damage, and their growth, were also carried out. Based on the data obtained from the assays, significant changes were observed in the parameters measured due to Messenger treatment. The severe damage of this disease was reduced in the plants which received Messenger applications. These results open up new pathways in the control of diseases like Phytophthora infestans, in which effective means to combat them still do not exist, or these means are harmful to the environment.

  5. The Timing of Maternal Depressive Symptoms and Child Cognitive Development: A Longitudinal Study

    Science.gov (United States)

    Evans, Jonathan; Melotti, Roberto; Heron, Jon; Ramchandani, Paul; Wiles, Nicola; Murray, Lynne; Stein, Alan

    2012-01-01

    Background: Maternal depression is known to be associated with impairments in child cognitive development, although the effect of timing of exposure to maternal depression is unclear. Methods: Data collected for the Avon Longitudinal Study of Parents and Children, a longitudinal study beginning in pregnancy, included self-report measures of…

  6. Exotic geophysical phenomena observed in an environmental neutron flux study using EAS PRISMA detectors

    Directory of Open Access Journals (Sweden)

    Alekseenko Victor

    2017-01-01

    Full Text Available Some exotic geophysical events are observed by a global net of electron-neutron detectors (en-detectors developed in the framework of the PRISMA EAS project. Our en-detectors running both on the Earth's surface and underground are continuously measuring the environmental thermal neutron flux. Thermal neutrons are in equilibrium with media and are therefore sensitive to many geophysical phenomena, which are exotic for people studying ultra high-energy cosmic rays or carrying out low background experiments deep underground.

  7. Spectral Analysis, Synthesis, & Energy Distributions of Nearby E+A Galaxies Using SDSS-IV MaNGA

    Science.gov (United States)

    Weaver, Olivia A.; Anderson, Miguel Ricardo; Wally, Muhammad; James, Olivia; Falcone, Julia; Liu, Allen; Wallack, Nicole; Liu, Charles; SDSS Collaboration

    2017-01-01

    Utilizing data from the Mapping Nearby Galaxies at APO (MaNGA) Survey (MaNGA Product Launch-4, or MPL-4), of the latest generation of the Sloan Digital Sky Survey (SDSS-IV), we identified nine post-starburst (E+A) systems that lie within the Green Valley transition zone. We identify the E+A galaxies by their SDSS single fiber spectrum and u-r color, then confirmed their classification as post-starburst by coding/plotting methods and spectral synthesis codes (FIREFLY and PIPE3D), as well as with their Spectral Energy Distributions (SEDs) from 0.15 µm to 22 µm, using GALEX, SDSS, 2MASS, and WISE data. We produced maps of gaussian-fitted fluxes, equivalent widths, stellar velocities, metallicities and age. We also produced spectral line ratio diagrams to classify regions of stellar populations of the galaxies. We found that our sample of E+As retain their post-starburst properties across the entire galaxy, not just at their center. We detected matching a trend line in the ultraviolet and optical bands, consistent with the expected SEDs for an E+A galaxy, and also through the J, H and Ks bands, except for one object. We classified one of the nine galaxies as a luminous infrared galaxy, unusual for a post-starburst object. Our group seeks to further study stellar population properties, spectral energy distributions and quenching properties in E+A galaxies, and investigate their role in galaxy evolution as a whole. This work was supported by the Alfred P. Sloan Foundation via the SDSS-IV Faculty and Student Team (FAST) initiative, ARC Agreement #SSP483 to the CUNY College of Staten Island. This work was also supported by grants to The American Museum of Natural History, and the CUNY College of Staten Island through from National Science Foundation.

  8. Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018

    Directory of Open Access Journals (Sweden)

    Wang Shengyue

    2011-02-01

    Full Text Available Abstract Background Clostridium acetobutylicum, a gram-positive and spore-forming anaerobe, is a major strain for the fermentative production of acetone, butanol and ethanol. But a previously isolated hyper-butanol producing strain C. acetobutylicum EA 2018 does not produce spores and has greater capability of solvent production, especially for butanol, than the type strain C. acetobutylicum ATCC 824. Results Complete genome of C. acetobutylicum EA 2018 was sequenced using Roche 454 pyrosequencing. Genomic comparison with ATCC 824 identified many variations which may contribute to the hyper-butanol producing characteristics in the EA 2018 strain, including a total of 46 deletion sites and 26 insertion sites. In addition, transcriptomic profiling of gene expression in EA 2018 relative to that of ATCC824 revealed expression-level changes of several key genes related to solvent formation. For example, spo0A and adhEII have higher expression level, and most of the acid formation related genes have lower expression level in EA 2018. Interestingly, the results also showed that the variation in CEA_G2622 (CAC2613 in ATCC 824, a putative transcriptional regulator involved in xylose utilization, might accelerate utilization of substrate xylose. Conclusions Comparative analysis of C. acetobutylicum hyper-butanol producing strain EA 2018 and type strain ATCC 824 at both genomic and transcriptomic levels, for the first time, provides molecular-level understanding of non-sporulation, higher solvent production and enhanced xylose utilization in the mutant EA 2018. The information could be valuable for further genetic modification of C. acetobutylicum for more effective butanol production.

  9. Harlamov selgitab EAS-i nõukogule BNS-ist lahkumist / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2005-01-01

    Ettevõtluse Arendamise Sihtasutuse juhatuse esimehe kandidaadilt Oleg Harlamovilt, praeguselt majandus- ja kommunikatsiooniminister Edgar Savisaare nõunikult, plaanitakse küsida tema BNS-ist lahkumise kohta. Lisa: Varrak: EAS pole kellegi rahapump

  10. Mitigating effects of the home environment on inattention and overactivity in children adopted from Romanian orphanages: a longitudinal study

    OpenAIRE

    Audet, Karyn Nicole

    2008-01-01

    This longitudinal study examined the potential mitigating effects of the adoptive home environment on inattention and overactivity (I/O) in children adopted from Romanian orphanages. Three groups were studied: (1) Children who experienced at least 8 months of deprivation in an orphanage prior to being adopted to British Columbia (RO group), (2) Children adopted to British Columbia from Romanian orphanages prior to 4-months-of-age (EA group), and (3) Canadian born non-adopted children (CB grou...

  11. Prediction of the development of reading comprehension: a longitudinal study

    NARCIS (Netherlands)

    Verhoeven, L.T.W.; Leeuwe, J.F.J. van

    2008-01-01

    Specific effects of word decoding, vocabulary and listening comprehension abilities on the development of reading comprehension were longitudinally examined for a representative sample of 2143 Dutch children throughout the elementary school period. An attempt was made to test two theoretical

  12. Simulating the energy deposits of particles in the KASCADE-grande detector stations as a preliminary step for EAS event reconstruction

    International Nuclear Information System (INIS)

    Toma, G.; Brancus, I.M.; Mitrica, B.; Sima, O.; Rebel, H.; Haungs, A.

    2005-01-01

    The study of primary cosmic rays with energies higher than 10 14 eV is done mostly by indirect observation techniques such as the study of Extensive Air Showers (EAS). In the much larger framework effort of inferring data on the mass and energy of the primaries from EAS observables, the present study aims at developing a versatile method and software tool that will be used to reconstruct lateral particle densities from the energy deposits of particles in the KASCADE-Grande detector stations. The study has been performed on simulated events, by taking into account the interaction of the EAS components with the detector array (energy deposits). The energy deposits have been simulated using the GEANT code and then the energy deposits have been parametrized for different incident energies and angles of EAS particles. Thus the results obtained for simulated events have the same level of consistency as the experimental data. This technique will allow an increased speed of lateral particle density reconstruction when studying real events detected by the KASCADE-Grande array. The particle densities in detectors have been reconstructed from the energy deposits. A correlation between lateral particle density and primary mass and primary energy (at ∼600 m from shower core) has been established. The study puts great emphasis on the quality of reconstruction and also on the speed of the technique. The data obtained from the study on simulated events creates the basis for the next stage of the study, the study of real events detected by the KASCADE-Grande array. (authors)

  13. Estimation of primary cosmic ray characteristics with the help of EAS Cherenkov light

    International Nuclear Information System (INIS)

    Aleksandrov, L.; Brankova, M.; Kirov, I.; Mishev, A.; Stamenov, J.; Ushev, S.; Mavrodiev, S.

    1999-01-01

    A new method of estimating primary cosmic ray characteristics based on the registration and analysis of EAS Cherenkov light is proposed. The nature, energy and arrival direction of primaries are obtained as a solution of a nonlinear inverse problem. The applied mathematical model is created by analyzing 'Hotovo' telescope experimental data. The behaviour of model parameters is studied using CORSIKA code for the primary energy interval 30 GeV-3 TeV. This method could be applied successfully for a different kind of detector displacements of EAS arrays. Moreover, it is shown that the shower parameter estimation could be obtained more effectively and precisely in the case of detectors displacement according to a Spiral

  14. Factors contributing to the longitudinal development of social participation in individuals with cerebral palsy

    NARCIS (Netherlands)

    Tan, Siok Swan; van der Slot, Wilma M A; Ketelaar, Marjolijn; Becher, Jules G.; Dallmeijer, Annet J.; Smits, Dirk Wouter; Roebroeck, Marij E.

    2016-01-01

    Aims We aimed to determine factors associated with the longitudinal development of social participation in a Dutch population of individuals with Cerebral Palsy (CP) aged 1–24 years. Methods and procedures For this multicentre prospective longitudinal study, 424 individuals with CP aged 1–24 years

  15. Capacidades do Estado brasileiro e arquitetura institucional da EaD: da organização burocrática à autonomia inserida dos órgãos estatais

    Directory of Open Access Journals (Sweden)

    Daniela da Costa Britto Pereira Lima

    2018-04-01

    Full Text Available Resumo: O tema deste estudo é a arquitetura institucional da educação a distância (EaD no Brasil sob a ótica das capacidades do Estado no que se refere à organização burocrática. Seu objetivo geral é apresentar e discutir algumas das capacidades do Estado brasileiro para gerir sua política pública de EaD. A pesquisa é do tipo bibliográfica e de natureza empírica, com suporte teórico em Evans (1993, 1995, 2004. O estudo empírico considerou o mapeamento e a análise da arquitetura institucional da EaD no Brasil entre 2010 e 2013 (LIMA, 2013. Constata-se que o Estado precisa rever sua arquitetura institucional da EaD, visando desenvolver a sua capacidade de organização burocrática e autonomia inserida, para passar de um Estado intermediário para desenvolvimentista. Palavras-chave: Educação a distância; educação superior; capacidades do Estado; arquitetura institucional.   Abstract: The theme of this study is the institutional architecture of distance education - EaD - in Brazil, from the point of view of the state's capabilities, regarding the bureaucratic organization. Its general objective is to present and discuss some of the capabilities of the Brazilian State to manage it's public DE policy. The research is a bibliographical and empirical study, with theoretical support in Evans (1993, 1995, 2004. The empirical study considered the mapping and analysis of the institutional architecture of EaD in Brazil between 2010 and 2013 (LIMA, 2013. It concludes that the Brazilian State needs to reassess its DE institutional architecture as a means to develop its bureaucratic organization capacity and inserted autonomy, and as a condition to move from an intermediary State to a developed one. Keywords: distance education; higher education; State capacity; institutional architecture.   Resumen: El tema de este estudio es la arquitectura institucional de la educación a distancia (EaD en Brasil bajo la óptica de las capacidades

  16. Slow and fast light in SOA-EA structures for phased-array antennas

    DEFF Research Database (Denmark)

    Sales, S.; Öhman, Filip; Bermejo, A.

    We present an SOA-EA structure for controlling the phase and amplitude of optically fed phased-array antennas. Phase shifts of 40 degrees are obtained through slow and fast light effects by changing only the reverse voltage....

  17. Longitudinal MRI Study of Cortical Development through Early Childhood in Autism

    Science.gov (United States)

    Schumann, C.M.; Bloss, C.S.; Barnes, C. Carter; Wideman, G.M.; Carper, R.A.; Akshoomoff, N.; Pierce, K.; Hagler, D.; Schork, N.; Lord, C.; Courchesne, E.

    2010-01-01

    Cross-sectional MRI studies have long hypothesized that the brain in children with autism undergoes an abnormal growth trajectory that includes a period of early overgrowth; however this has never been confirmed by a longitudinal study. We carried out the first longitudinal study of brain growth in toddlers at the time symptoms of autism are becoming clinically apparent utilizing structural MRI scans at multiple time points beginning at 1.5 years up to 5 years of age. We collected 193 scans on 41 toddlers who received a confirmed diagnosis of Autistic Disorder at ~48 months of age and 44 typically developing controls. By 2.5 years of age, both cerebral gray and white matter was significantly enlarged in toddlers with Autistic Disorder, with the most severe enlargement occurring in frontal, temporal and cingulate cortices. In the longitudinal analyses, which we accounted for age and gender effect, we found that all regions (cerebral gray, cerebral white, frontal gray, temporal gray, cingulate gray, and parietal gray) except occipital gray developed at an abnormal growth rate in toddlers with Autistic Disorder that was mainly characterized by a quadratic age effect. Females with Autistic Disorder displayed a more pronounced abnormal growth profile in more brain regions than males with the disorder. Given that overgrowth clearly begins before 2 years of age, future longitudinal studies would benefit from inclusion of even younger populations as well as further characterization of genetic and other biomarkers in order to determine the underlying neuropathological processes causing the onset of autistic symptoms. PMID:20335478

  18. Evaluation of RSDL, M291 SDK, 0.5% Bleach, 1% Soapy Water and SERPACWA. Part 12: Challenge with EA1212 (GF, cyclosarin)

    Science.gov (United States)

    2016-01-01

    products in the haired guinea pig model following exposure to GF (EA1212). 15. SUBJECT TERMS decontamination, delayed decontamination, Reactive Skin...the four listed decontamination products in the haired guinea pig model following exposure to GF (EA1212). In all experiments, guinea pigs were close...the four listed decontamination products and SERPACWA in the haired guinea pig model following exposure to GF [cyclosarin, EA1212, Cyclohexyl

  19. 75 FR 61345 - Airworthiness Directives; Eclipse Aerospace, Inc. Model EA500 Airplanes

    Science.gov (United States)

    2010-10-05

    ... Airworthiness Directives; Eclipse Aerospace, Inc. Model EA500 Airplanes AGENCY: Federal Aviation Administration... service information identified in this AD, contact Eclipse Aerospace Incorporated, 2503 Clark Carr Loop... Kinney, Aerospace Engineer, Ft. Worth Aircraft Certification Office, FAA, 2601 Meacham Blvd., Fort Worth...

  20. 47 CFR 11.51 - EAS code and Attention Signal Transmission requirements.

    Science.gov (United States)

    2010-10-01

    ... interfere with other visual messages. (e) Analog class D non-commercial educational FM stations as defined in § 73.506 of this chapter, digital class D non-commercial educational FM stations, analog Low Power... Message (EOM) codes using the EAS Protocol. The Attention Signal must precede any emergency audio message...

  1. Searching saturation effects in inclusive and exclusive eA processes

    International Nuclear Information System (INIS)

    Goncalves, V.P.

    2016-01-01

    In this contribution we have discussed the search of saturation effects in inclusive and exclusive eA processes. In particular, we present a comparison between the linear and non-linear predictions for the nuclear structure functions as well as for the Deep Virtual Compton Scattering (DVCS) and vector meson production in future eA colliders. These results demonstrated that although the inclusive observables are sensitive to saturation effects, it is not yet possible to draw any firm conclusion concerning the QCD dynamics from inclusive quantities due to the large uncertainty present in the collinear predictions. In contrast, exclusive processes are promising observables to search saturation effects, due to the quadratic dependence on the forward scattering amplitude. In particular, the analysis of the nuclear DVCS and vector meson production demonstrated that the energy dependence of the differential cross sections are strongly modified with the increasing of the atomic mass number and that coherent cross section dominates at small t and the incoherent one at large t. Moreover, the number of dips at small t increases with the atomic number, with the position of the dips being almost independent of the model used to treat the dipole - proton interaction

  2. 47 CFR 11.55 - EAS operation during a State or Local Area emergency.

    Science.gov (United States)

    2010-10-01

    ..., earthquakes, heavy snows, icing conditions, widespread fires, etc. Man-made emergencies may include: toxic gas...) SDARS licensees and DBS providers may participate in EAS at the state and local level and make their...

  3. Headspace solid phase microextraction--GC/C-IRMS for delta13CVPDB measurements of mono-aromatic hydrocarbons using EA-IRMS calibration.

    Science.gov (United States)

    Ebongué, Véronique Woule; Geypens, Benny; Berglund, Michael; Taylor, Philip

    2009-03-01

    This work aims at comparing the delta(13)C(VPDB) of mono-aromatic hydrocarbons benzene, toluene, ethylbenzene and xylene isomers (BTEX) measured by elemental analyser (EA)-isotope ratio mass spectrometer (IRMS) with the delta(13)C(VPDB) measured on the same compounds by headspace solid phase microextraction - GC/C-IRMS (hSPME - GC/C-IRMS) with the final goal of using these compounds as internal standards on the latter system. The EA-IRMS measurements were done using calcium and lithium carbonate isotopic reference materials: NBS19 and L-SVEC for establishing the delta(13)C(VPDB) scale. The EA-IRMS measurements with helium dilution of a set of five reference materials (USGS40, USGS41, IAEA-CH-6, IAEA-CH-3 and IAEA-601) show systematic bias of 1 per thousand relative to their assigned values. This bias due to the dilution mechanism in the used ConfloII interface device could not be avoided. As the selected hydrocarbons: BTEX could not be analysed by EA-IRMS without helium dilution, their delta(13)C(VPDB) must be corrected from this observed bias using an external calibration. The CO(2) gas calibrated using EA-IRMS without helium dilution, was used as an in-house reference for the delta(13)C(VPDB) measurements of the BTEX by the hSPME - GC/C-IRMS system. The comparison made between the delta(13)C(VPDB) measured on the same BTEX compounds by EA-IRMS (with external calibration) and by hSPME - GC/C-IRMS techniques showed good agreement.

  4. Influence of wind on aerodynamic drag for the second case of the arrangement of the equipment on the LE 060EA locomotive bodywork

    Directory of Open Access Journals (Sweden)

    Sorin ARSENE

    2015-06-01

    Full Text Available The electric power supply equipment of electric railways vehicles of surface is placed on the their body. The arrangement of the equipment on the vehicle body determines the variation of the aerodynamic drag. The gusts of wind occurring during the vehicle movement result in additional requests. The case of the locomotive of type LE 060 EA 5100kW moving with the second driving position is analyzed in this paper. For this particular case the components ensemble of the power supply system was geometric modelled in 3D format at 1:1 scale. The resulted model was placed in air flow simulation software to determine the aerodynamic resistance. The wind influence is analyzed for five point values of its speed. The wind direction is simulated by eight point values of the angle that it makes to the longitudinal axis of the vehicle.

  5. A longitudinal study on gross motor development in children with learning disorders

    NARCIS (Netherlands)

    Westendorp, Marieke; Hartman, Esther; Houwen, Suzanne; Huijgen, Barbara C. H.; Smith, Joanne; Visscher, Chris

    This longitudinal study examined the development of gross motor skills, and sex-differences therein, in 7; to 11-years-old children with learning disorders (LD) and compared the results with typically developing children to determine the performance level of children with LD. In children with LD (n

  6. Ultrastructural changes in the membrane system of isolated chloroplasts of spinach under the influence of carbonic anhydrase inhibitors AA and EA

    Directory of Open Access Journals (Sweden)

    Marina V. Vodka

    2013-04-01

    Full Text Available The effects of carbonic anhydrase inhibitors (АА and EA on the membrane system of isolated chloroplasts of spinach were investigated. Under the influence of AA the considerable alterations in granal structure occurred, the thickness of the granal thylakoids increased by 36% and the interspace between thylakoids by 10% comparable with the control. As a result of EA treatment, the thickness of granal thylakoids enhanced by 31% and the interspace between thylakoids increased by 8% in comparison to the control. It was shown that structure of the granal system of the chloroplast was more sensitive to AA than EA. The data obtained can indicate a decrease in the activity of the thylakoid carbonic anhydrase, inhibition of electron transport and photosynthetic process as a whole in the presence of carbonic anhydrase inhibitors (AA and EA.

  7. 85 km Long Reach PON System Using a Reflective SOA-EA Modulator and Distributed Raman Fiber Amplification

    DEFF Research Database (Denmark)

    Tafur Monroy, Idelfonso; Öhman, Filip; Yvind, Kresten

    2006-01-01

    We report on a bidirectional 85 km long reach PON system supported by distributed fiber Raman amplification with a record 7.5 Gb/s remote carrier modulated upstream signal by employing a reflective SOA-EA monolithically integrated circuit......We report on a bidirectional 85 km long reach PON system supported by distributed fiber Raman amplification with a record 7.5 Gb/s remote carrier modulated upstream signal by employing a reflective SOA-EA monolithically integrated circuit...

  8. Impacts of the EA and SCA patterns on the 20th century NAO-winter precipitation relationship in Europe

    Science.gov (United States)

    Comas-Bru, Laia; McDermott, Frank

    2013-04-01

    Much of the 20th century multi-decadal variability in the NAO-winter precipitation relationship over the N. Atlantic / European sector can be ascribed to the combined effects of the North Atlantic Oscillation (NAO) and either the East Atlantic pattern (EA) or the Scandinavian pattern (SCA). The NAO, EA and SCA indices employed here are defined as the three leading vectors of the cross-correlation matrix calculated from monthly sea-level pressure anomalies for 138 complete winters from the 20CRv2 dataset (Compo et al., 2011). Winter precipitation data over Europe for the entire 20th century is derived from the high resolution CRU-TS3.1 climate dataset (Mitchell and Jones, 2005). Here we document for the first time, that different NAO/EA and NAO/SCA combinations systematically influence winter precipitation conditions in Europe as a consequence of NAO dipole migrations. We find that the zero-correlated line of the NAO-winter precipitation relationship migrates southwards when the EA is in the opposite phase to the NAO. This can be related to a south-westwards migration of the NAO dipole under these conditions, as shown by teleconnectivity maps. Similarly, a clockwise movement of the NAO-winter climate correlated areas occurs when the phase of the SCA is opposite to that of the NAO, reflecting a clockwise movement of the NAO dipole under these conditions. An important implication of these migrations is that they influence the spatial and temporal stationarity of climate-NAO relationships. As a result, the link between winter precipitation patterns and the NAO is not straightforward in some regions such as the southern UK, Ireland and France. For instance, much of the inter-annual variability in the N-S winter precipitation gradient in the UK, originally attributed to inter-annual and inter-decadal variability of the NAO, reflects the migration of the NAO dipole, linked to linear combinations of the NAO and the EA. Our results indicate that when the N-S winter

  9. Surface-water interface induces conformational changes critical for protein adsorption: Implications for monolayer formation of EAS hydrophobin

    Directory of Open Access Journals (Sweden)

    Kamron eLey

    2015-11-01

    Full Text Available The class I hydrophobin EAS is part of a family of small, amphiphilic fungal proteins best known for their ability to self-assemble into stable monolayers that modify the hydrophobicity of a surface to facilitate further microbial growth. These proteins have attracted increasing attention for industrial and biomedical applications, with the aim of designing surfaces that have the potential to maintain their clean state by resisting non-specific protein binding. To gain a better understanding of this process, we have employed all-atom molecular dynamics to study initial stages of the spontaneous adsorption of monomeric EAS hydrophobin on fully hydroxylated silica, a commonly used industrial and biomedical substrate. Particular interest has been paid to the Cys3-Cys4 loop, which has been shown to exhibit disruptive behavior in solution, and the Cys7-Cys8 loop, which is believed to be involved in the aggregation of EAS hydrophobin at interfaces. Specific and water mediated interactions with the surface were also analyzed. We have identified two possible binding motifs, one which allows unfolding of the Cys7-Cys8 loop due to the surfactant-like behavior of the Cys3-Cys4 loop, and another which has limited unfolding due to the Cys3-Cys4 loop remaining disordered in solution. We have also identified intermittent interactions with water which mediate the protein adsorption to the surface, as well as longer lasting interactions which control the diffusion of water around the adsorption site. These results have shown that EAS behaves in a similar way at the air-water and surface-water interfaces, and have also highlighted the need for hydrophilic ligand functionalization of the silica surface in order to prevent the adsorption of EAS hydrophobin.

  10. Applied longitudinal analysis

    CERN Document Server

    Fitzmaurice, Garrett M; Ware, James H

    2012-01-01

    Praise for the First Edition "". . . [this book] should be on the shelf of everyone interested in . . . longitudinal data analysis.""-Journal of the American Statistical Association   Features newly developed topics and applications of the analysis of longitudinal data Applied Longitudinal Analysis, Second Edition presents modern methods for analyzing data from longitudinal studies and now features the latest state-of-the-art techniques. The book emphasizes practical, rather than theoretical, aspects of methods for the analysis of diverse types of lo

  11. Optimal Mutation Rates for the (1+lambda) EA on OneMax Through Asymptotically Tight Drift Analysis

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2018-01-01

    We study the (1+) EA, a classical population-based evolutionary algorithm, with mutation probability c / n, where and are constant, on the benchmark function OneMax, which counts the number of 1-bits in a bitstring. We improve a well-established result that allows to determine the first hitting t...... that mutation rates up to 10% larger than the asymptotically optimal rate 1 / n minimize the expected runtime. However, in absolute terms the expected runtime does not change by much when replacing 1 / n with the optimal mutation rate....... drift is known. This reduces the analysis of expected optimization time to finding an exact expression for the drift. We then give an exact closed-form expression for the drift and develop a method to approximate it very efficiently, enabling us to determine approximate optimal mutation rates for the (1......+) EA for various parameter settings of c and and also for moderate sizes of n. This makes the need for potentially lengthy and costly experiments in order to optimize c for fixed n and for the optimization of OneMax unnecessary. Interestingly, even for moderate n and not too small it turns out...

  12. Characteristics of Ni-Cr-Fe laser clad layers on EA4T steel

    Science.gov (United States)

    Chen, Wenjing; Chen, Hui; Wang, Yongjing; Li, Congchen; Wang, Xiaoli

    2017-07-01

    The Ni-Cr-Fe metal powder was deposited on EA4T steel by laser cladding technology. The microstructure and chemical composition of the cladding layer were analyzed by optical microscopy (OM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The bonding ability between the cladding layer and the matrix was measured. The results showed that the bonding between the cladding layer and the EA4T steel was metallurgical bonding. The microstructure of cladding layer was composed of planar crystals, columnar crystals and dendrite, which consisted of Cr2Ni3, γ phase, M23C6 and Ni3B phases. When the powder feeding speed reached 4 g/min, the upper bainite occurred in the heat affected zone (HAZ). Moreover, the tensile strength of the joint increased, while the yield strength and the ductility decreased.

  13. Strength Pareto particle swarm optimization and hybrid EA-PSO for multi-objective optimization.

    Science.gov (United States)

    Elhossini, Ahmed; Areibi, Shawki; Dony, Robert

    2010-01-01

    This paper proposes an efficient particle swarm optimization (PSO) technique that can handle multi-objective optimization problems. It is based on the strength Pareto approach originally used in evolutionary algorithms (EA). The proposed modified particle swarm algorithm is used to build three hybrid EA-PSO algorithms to solve different multi-objective optimization problems. This algorithm and its hybrid forms are tested using seven benchmarks from the literature and the results are compared to the strength Pareto evolutionary algorithm (SPEA2) and a competitive multi-objective PSO using several metrics. The proposed algorithm shows a slower convergence, compared to the other algorithms, but requires less CPU time. Combining PSO and evolutionary algorithms leads to superior hybrid algorithms that outperform SPEA2, the competitive multi-objective PSO (MO-PSO), and the proposed strength Pareto PSO based on different metrics.

  14. The Role of Mediators in the Development of Longitudinal Mathematics Achievement Associations.

    Science.gov (United States)

    Watts, Tyler W; Duncan, Greg J; Chen, Meichu; Claessens, Amy; Davis-Kean, Pamela E; Duckworth, Kathryn; Engel, Mimi; Siegler, Robert; Susperreguy, Maria I

    2015-01-01

    Despite research demonstrating a strong association between early and later mathematics achievement, few studies have investigated mediators of this association. Using longitudinal data (n = 1,362), this study tested the extent to which mathematics self-concepts, school placement, executive functioning, and proficiency in fractions and division account for the association between mathematics achievement in first grade and at age 15. As hypothesized, a strong longitudinal association between first-grade and adolescent mathematics achievement was present (β = .36) even after controlling for a host of background characteristics, including cognitive skills and reading ability. The mediators accounted for 39% of this association, with mathematics self-concept, gifted and talented placement, and knowledge of fractions and division serving as significant mediators. © 2015 The Authors. Child Development © 2015 Society for Research in Child Development, Inc.

  15. An analytical framework for capacity development in EIA - The case of Yemen

    International Nuclear Information System (INIS)

    Loon, Louise van; Driessen, Peter P.J.; Kolhoff, Arend; Runhaar, Hens A.C.

    2010-01-01

    Most countries worldwide nowadays apply Environmental Assessment (EA) as an ex ante tool to evaluate environmental impacts of policies, plans, programmes, and projects. However, the application and performance of EA differ significantly. Scientific analysis of how EA performs mainly focuses on two levels: the micro (or project) level and the macro (or system) level. Macro level analysis usually focuses on institutions for EA and the organisation of stakeholder interaction in EA. This article proposes a more comprehensive framework for analysing EA systems that combines other approaches with a capacity approach and an explicit consideration of the context in which EA systems are developed and performed. In order to illustrate the value of our framework, we apply it to the Republic of Yemen, where over the last decades many EA capacity development programmes have been executed; however, EA performance has not substantially improved. The Yemen case study illustrates that the capacity development approach allows an understanding of the historical process, the stakeholders, the knowledge component, and the material and technical aspects of EA, but perhaps more important is a systemic understanding of the outcomes: problems are not isolated, but influence and even maintain each other. In addition, by taking into account the context characteristics, our framework allows for the assessment of the feasibility of capacity development programmes that aim at improving EA system performance.

  16. Determining the primary cosmic ray energy from the total flux of Cherenkov light measured at the Yakutsk EAS array

    International Nuclear Information System (INIS)

    Ivanov, A. A.; Knurenko, S. P.; Sleptsov, I. E.

    2007-01-01

    We present a method for determining the energy of the primary particle that generates an extensive air shower (EAS) of comic rays based on measuring the total flux of Cherenkov light from the shower. Applying this method to Cherenkov light measurements at the Yakutsk EAS array has allowed us to construct the cosmic ray energy spectrum in the range 10 15 - 3 x 10 19 eV

  17. EurEAs_Gplex--A new SNaPshot assay for continental population discrimination and gender identification.

    Science.gov (United States)

    Daca-Roszak, P; Pfeifer, A; Żebracka-Gala, J; Jarząb, B; Witt, M; Ziętkiewicz, E

    2016-01-01

    Assays that allow analysis of the biogeographic origin of biological samples in a standard forensic laboratory have to target a small number of highly differentiating markers. Such markers should be easy to multiplex and the assay must perform well in the degraded and scarce biological material. SNPs localized in the genome regions, which in the past were subjected to differential selective pressure in various populations, are the most widely used markers in the studies of biogeographic affiliation. SNPs reflecting biogeographic differences not related to any phenotypic traits are not sufficiently explored. The goal of our study was to identify a small set of SNPs not related to any known pigmentation/phenotype-specific genes, which would allow efficient discrimination between populations of Europe and East Asia. The selection of SNPs was based on the comparative analysis of representative European and Chinese/Japanese samples (B-lymphocyte cell lines), genotyped using the Infinium HumanOmniExpressExome microarray (Illumina). The classifier, consisting of 24 unlinked SNPs (24-SNP classifier), was selected. The performance of a 14-SNP subset of this classifier (14-SNP subclassifier) was tested using genotype data from several populations. The 14-SNP subclassifier differentiated East Asians, Europeans and Africans with ∼100% accuracy; Palestinians, representative of the Middle East, clustered with Europeans, while Amerindians and Pakistani were placed between East Asian and European populations. Based on these results, we have developed a SNaPshot assay (EurEAs_Gplex) for genotyping SNPs from the 14-SNP subclassifier, combined with an additional marker for gender identification. Forensic utility of the EurEAs_Gplex was verified using degraded and low quantity DNA samples. The performance of the EurEAs_Gplex was satisfactory when using degraded DNA; tests using low quantity DNA samples revealed a previously not described source of genotyping errors, potentially

  18. Lead-resistant Providencia alcalifaciens strain 2EA bioprecipitates Pb+2 as lead phosphate.

    Science.gov (United States)

    Naik, M M; Khanolkar, D; Dubey, S K

    2013-02-01

    A lead-resistant bacteria isolated from soil contaminated with car battery waste were identified as Providencia alcalifaciens based on biochemical characteristics, FAME profile and 16S rRNA sequencing and designated as strain 2EA. It resists lead nitrate up to 0·0014 mol l(-1) by precipitating soluble lead as insoluble light brown solid. Scanning electron microscopy coupled with energy-dispersive X-ray spectrometric analysis (SEM-EDX) and X-ray diffraction spectroscopy (XRD) revealed extracellular light brown precipitate as lead orthophosphate mineral, that is, Pb(9) (PO(4))(6) catalysed by phosphatase enzyme. This lead-resistant bacterial strain also demonstrated tolerance to high levels of cadmium and mercury along with multiple antibiotic resistance. Providencia alcalifaciens strain 2EA could be used for bioremediation of lead-contaminated environmental sites, as it can efficiently precipitate lead as lead phosphate. © 2012 The Society for Applied Microbiology.

  19. Measurement of organic carbon stable isotope composition of different soil types by EA-IRMS system

    International Nuclear Information System (INIS)

    Qi Biao; Ding Lingling; Cui Jiehua; Wang Yanhong

    2009-01-01

    Element analyzer-isotope ratio mass spectrometers (EA-IRMS) is a rapid and precise method for measuring stable carbon isotope. Pure CO 2 reference gas was calibrated via international standard-Urea, and the δ 13 C us PDB value of pure CO 2 is (-29.523 ± 0.0181)%. Stability and linearity of the EA-IRMS system, precision of δ 13 C measurement for samples were tested through experimental comparison. Moreover, determination method of organic carbon stable isotope in soil was based on the system. The EA-IRMS system had well linearity when ion intensity ranged from 1.0 to 7.0V, and it excelled the total linearity when the ion intensity was from 1.5 to 5.0V, and the accurate result of δ 13 C for sample analysis could be obtained with precision of 0.015%. If carbon content in sample is more than 5μg, the requirement for analyzing accurate result of δ 13 C could be achieved. The organic carbon stable isotope was measured in 18 different types soil samples, the average natural abundance of 13 C was 1.082%, and the organic carbon stable isotope composition was significantly different among different type soils. (authors)

  20. Restoration of longitudinal images.

    Science.gov (United States)

    Hu, Y; Frieden, B R

    1988-01-15

    In this paper, a method of restoring longitudinal images is developed. By using the transfer function for longitudinal objects, and inverse filtering, a longitudinal image may be restored. The Fourier theory and sampling theorems for transverse images cannot be used directly in the longitudinal case. A modification and reasonable approximation are introduced. We have numerically established a necessary relationship between just-resolved longitudinal separation (after inverse filtering), noise level, and the taking conditions of object distance and lens diameter. An empirical formula is also found to well-fit the computed results. This formula may be of use for designing optical systems which are to image longitudinal details, such as in robotics or microscopy.

  1. Special report. Update on EAS (electronic article surveillance) systems: protecting against patient wandering, infant abduction, property theft.

    Science.gov (United States)

    1993-10-01

    Concern about wandering patients and infant abduction on the part of hospitals has sparked renewed interest in Electronic Article Surveillance (EAS) systems. Such systems had their origins in department stores and libraries where they are almost universally used. They also have applications in hospitals for preventing the theft of supplies and equipment. A number of companies provide EAS products for the health care field. How do you select the system that is best for your needs? "Talk to users. Pick out a number of profit and non-profit hospitals to get their views," advises Ted Algaier, vice president, marketing and sales, Innovative Control Systems, Inc., Waukesha, WI. "Examine the history of the company or vendor to determine if it understands the health care market and find out if the product really works." In this report, we'll review a number of EAS systems currently on the market, and present information on how they work, how effective they are, and costs involved. Also included are comments from users who have installed such systems.

  2. Longitudinal categorical data analysis

    CERN Document Server

    Sutradhar, Brajendra C

    2014-01-01

    This is the first book in longitudinal categorical data analysis with parametric correlation models developed based on dynamic relationships among repeated categorical responses. This book is a natural generalization of the longitudinal binary data analysis to the multinomial data setup with more than two categories. Thus, unlike the existing books on cross-sectional categorical data analysis using log linear models, this book uses multinomial probability models both in cross-sectional and longitudinal setups. A theoretical foundation is provided for the analysis of univariate multinomial responses, by developing models systematically for the cases with no covariates as well as categorical covariates, both in cross-sectional and longitudinal setups. In the longitudinal setup, both stationary and non-stationary covariates are considered. These models have also been extended to the bivariate multinomial setup along with suitable covariates. For the inferences, the book uses the generalized quasi-likelihood as w...

  3. Ensino da oralidade em Língua Estrangeira na EaD através de programas de comunicação síncrona. L2 speech teaching in Distance Education (EaD through synchronous communication softwares

    Directory of Open Access Journals (Sweden)

    Estivalet, Gustavo L.

    2014-11-01

    Full Text Available From the increasing growth of foreign language courses in distance education (EaD, information and communication technology (TIC have been playing a key role for the success of teaching and learning of speaking skills. Hence, synchronous communication softwares such as MSN, GoogleTalk, Skype, Voip, Dim-Dim, VZO Chat, Facebook, among others, have become essential tools for developing this skill in the interaction between students and teachers. Thus, this paper a makes a brief theoretical review of these softwares’ use in teaching speaking skills, b evaluates their use in the UFSC undergraduate distance course on Literature – Bachelor in English Language Teaching, and c discusses the use of synchronous communication softwares for teaching foreign languages in distance education. The adopted methodology included 1 observation on the use of these softwares during the course, 2 a questionnaire answered by the students, and 3 interviews with the teachers. It was observed that these softwares were used mostly in evaluation situations and that there is a demand from the students for broader interaction in foreign language through these tools in a didactic manner. Therefore, in order to develop speaking skills in foreign language in distance education, it is necessary an effective teaching practice through synchronous communication softwares. A partir do grande crescimento dos cursos de línguas estrangeiras (LE na educação a distância (EaD, as tecnologias de informação e comunicação (TIC passaram a desempenhar um papel fundamental nos processos de ensino e aprendizagem da oralidade em LE. Logo, os programas de comunicação síncrona, como MSN, GoogleTalk, Skype, Voip, Dim-Dim, VZO Chat, Facebook, entre outros, tornaram-se ferramentas essenciais na interação entre alunos e professores no desenvolvimento dessa habilidade. Este artigo realiza a uma breve revisão teórica da utilização desses programas no ensino da oralidade em LE, b avalia

  4. U.H.E. γ-ray observations with the EAS-TOP array

    International Nuclear Information System (INIS)

    Aglietta, M.; Alessandro, B.; Arneodo, F.; Badino, G.; Bergamasco, L.; Castagnoli, C.; Castellina, A.; Cattadori, C.; Chiavassa, A.; Cini, G.; Piazzoli, B.D.; Fulgione, W.; Ghia, P.L.; Galeotti, P.; Mannocchi, G.; Morello, C.; Navarra, G.; Periale, L.; Riccati, L.; Saavedra, O.; Trinchero, G.C.; Vallania, P.; Vernetto, S.

    1991-01-01

    The EAS-TOP array at Gran Sasso (Italy) has been fully operating as a gamma-ray astronomy observatory since the beginning of 1989 (energy range 10 14 -10 17 eV). We present the results on search for gamma ray emission from candidate point sources in northern hemisphere obtained by data collected through 1989-1990. The UHE energy event observed from Crab Nebula on February 23rd, 1989, is also discussed

  5. A comparison of genotyping-by-sequencing analysis methods on low-coverage crop datasets shows advantages of a new workflow, GB-eaSy.

    Science.gov (United States)

    Wickland, Daniel P; Battu, Gopal; Hudson, Karen A; Diers, Brian W; Hudson, Matthew E

    2017-12-28

    Genotyping-by-sequencing (GBS), a method to identify genetic variants and quickly genotype samples, reduces genome complexity by using restriction enzymes to divide the genome into fragments whose ends are sequenced on short-read sequencing platforms. While cost-effective, this method produces extensive missing data and requires complex bioinformatics analysis. GBS is most commonly used on crop plant genomes, and because crop plants have highly variable ploidy and repeat content, the performance of GBS analysis software can vary by target organism. Here we focus our analysis on soybean, a polyploid crop with a highly duplicated genome, relatively little public GBS data and few dedicated tools. We compared the performance of five GBS pipelines using low-coverage Illumina sequence data from three soybean populations. To address issues identified with existing methods, we developed GB-eaSy, a GBS bioinformatics workflow that incorporates widely used genomics tools, parallelization and automation to increase the accuracy and accessibility of GBS data analysis. Compared to other GBS pipelines, GB-eaSy rapidly and accurately identified the greatest number of SNPs, with SNP calls closely concordant with whole-genome sequencing of selected lines. Across all five GBS analysis platforms, SNP calls showed unexpectedly low convergence but generally high accuracy, indicating that the workflows arrived at largely complementary sets of valid SNP calls on the low-coverage data analyzed. We show that GB-eaSy is approximately as good as, or better than, other leading software solutions in the accuracy, yield and missing data fraction of variant calling, as tested on low-coverage genomic data from soybean. It also performs well relative to other solutions in terms of the run time and disk space required. In addition, GB-eaSy is built from existing open-source, modular software packages that are regularly updated and commonly used, making it straightforward to install and maintain

  6. Positive parenting predicts the development of adolescent brain structure: A longitudinal study

    Directory of Open Access Journals (Sweden)

    Sarah Whittle

    2014-04-01

    Full Text Available Little work has been conducted that examines the effects of positive environmental experiences on brain development to date. The aim of this study was to prospectively investigate the effects of positive (warm and supportive maternal behavior on structural brain development during adolescence, using longitudinal structural MRI. Participants were 188 (92 female adolescents, who were part of a longitudinal adolescent development study that involved mother–adolescent interactions and MRI scans at approximately 12 years old, and follow-up MRI scans approximately 4 years later. FreeSurfer software was used to estimate the volume of limbic-striatal regions (amygdala, hippocampus, caudate, putamen, pallidum, and nucleus accumbens and the thickness of prefrontal regions (anterior cingulate and orbitofrontal cortices across both time points. Higher frequency of positive maternal behavior during the interactions predicted attenuated volumetric growth in the right amygdala, and accelerated cortical thinning in the right anterior cingulate (males only and left and right orbitofrontal cortices, between baseline and follow up. These results have implications for understanding the biological mediators of risk and protective factors for mental disorders that have onset during adolescence.

  7. A Longitudinal Study of Pragmatic Language Development in Three Children with Cochlear Implants

    Science.gov (United States)

    Dammeyer, Jesper

    2012-01-01

    Research has shown how cochlear implants (CIs), in children with hearing impairments, have improved speech perception and production, but very little is known about the children's pragmatic language development. During a 4-year longitudinal study of three children with CIs, certain aspects of pragmatic language development were observed in free…

  8. Maternal Weight Predicts Children's Psychosocial Development via Parenting Stress and Emotional Availability.

    Science.gov (United States)

    Bergmann, Sarah; Schlesier-Michel, Andrea; Wendt, Verena; Grube, Matthias; Keitel-Korndörfer, Anja; Gausche, Ruth; von Klitzing, Kai; Klein, Annette M

    2016-01-01

    Maternal obesity has been shown to be a risk factor for obesity in children and may also affect children's psychosocial outcomes. It is not yet clear whether there are also psycho-emotional mechanisms explaining the effects of maternal weight on young children's weight and psychosocial development. We aimed to evaluate whether maternal body mass index (BMI), mother-child emotional availability (EA), and maternal parenting stress are associated with children's weight and psychosocial development (i.e., internalizing/externalizing symptoms and social competence) and whether these predictors interact with each other. This longitudinal study included three assessment points (~11 months apart). The baseline sample consisted of N = 194 mothers and their children aged 5-47 months (M = 28.18, SD = 8.44, 99 girls). At t 1, we measured maternal weight and height to calculate maternal BMI. We videotaped mother-child interactions, coding them with the EA Scales (fourth edition). We assessed maternal parenting stress with the Parenting Stress Index (PSI) short form. At t 1 to t 3, we measured height and weight of children and calculated BMI-SDS scores. Children's externalizing and internalizing problems (t 1-t 3) and social competence (t 3, N = 118) were assessed using questionnaires: Child Behavior Checklist (CBCL 1.5-5), Strengths and Difficulties Questionnaire (SDQ: prosocial behavior), and a checklist for behavioral problems at preschool age (VBV 3-6: social-emotional competence). By applying structural equation modeling (SEM) and a latent regression analysis, we found maternal BMI to predict higher BMI-SDS and a poorer psychosocial development (higher externalizing symptoms, lower social competence) in children. Higher parenting stress predicted higher levels of externalizing and internalizing symptoms and lower social competence. Better maternal EA was associated with higher social competence. We found parenting stress to serve as a mediator in the association between

  9. Overcoming hybridization barriers by the secretion of the maize pollen tube attractant ZmEA1 from Arabidopsis ovules.

    Science.gov (United States)

    Márton, Mihaela L; Fastner, Astrid; Uebler, Susanne; Dresselhaus, Thomas

    2012-07-10

    A major goal of plant reproduction research is to understand and overcome hybridization barriers so that the gene pool of crop plants can be increased and improved upon. After successful pollen germination on a receptive stigma, the nonmotile sperm cells of flowering plants are transported via the pollen tube (PT) to the egg apparatus for the achievement of double fertilization. The PT path is controlled by various hybridization mechanisms probably involving a larger number of species-specific molecular interactions. The egg-apparatus-secreted polymorphic peptides ZmEA1 in maize and LURE1 and LURE2 in Torenia fournieri as well as TcCRP1 in T. concolor were shown to be required for micropylar PT guidance, the last step of the PT journey. We report here that ZmEA1 attracts maize PTs in vitro and arrests their growth at higher concentrations. Furthermore, it binds to the subapical region of maize PT tips in a species-preferential manner. To overcome hybridization barriers at the level of gametophytic PT guidance, we expressed ZmEA1 in Arabidopsis synergid cells. Secreted ZmEA1 enabled Arabidopsis ovules to guide maize PT in vitro in a species-preferential manner to the micropylar opening of the ovule. These results demonstrate that the egg-apparatus-controlled reproductive-isolation barrier of PT guidance can be overcome even between unrelated plant families. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Diet assessment in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil: Development of a food frequency questionnaire

    Directory of Open Access Journals (Sweden)

    Maria del Carmen Bisi Molina

    2013-04-01

    Full Text Available OBJECTIVE: The objective of this article is to present the development of the Food Frequency Questionaire used in the Longitudinal Study of Adult Health-Brazil and analyze how diet exposes individuals to cardiovascular diseases and type 2 diabetes Mellitus. METHODS: The Longitudinal Study of Adult Health-Brazil dietary assessment instrument is based on a previously validated Food Frequency Questionaire and the final list of items took into consideration a study done in the six Longitudinal Study of Adult Health-Brazil investigation centers. RESULTS: New foods/preparations were included in the Food Frequency Questionaire with their respective portions, totaling 114 items. The perspectives of dietary analysis and cardiovascular diseases and diabetes are presented in Longitudinal Study of Adult Health-Brazil. CONCLUSION: A new instrument was developed to cover the regional particularities of the study population.

  11. Integration of EA and IT service to improve performance at higher education organizations

    Directory of Open Access Journals (Sweden)

    Hermanto Agus

    2018-01-01

    Full Text Available One of the perceived benefits of the use of information technology is the increased accuracy and speed of information that greatly helped the operations of an institution or organization. Politeknik XYZ as one of the organizations / institutions in the field of education, now need to consider the strategic role of information technology in supporting academic activities and develop a wide range of academic services, especially for students. Accordingly, in this study has been carried out the planning and improvement of information technology services in accordance with EA and IT Service standards, based on analysis using ACMM maturity level. The end result of architectural planning and service enhancement developed with TOGAF and ITIL is to be used as a reference in the improvement the role of information systems and technology in supporting business process organizations at Polytechnic XYZ. This study demonstrates the importance of raising awareness of the interdependent relationship between architecture and quality of service management in the organization of information technology.

  12. HEAT TRANSFER EVALUATION OF HFC-236EA AND CFC-114 IN CONDENSATION AND EVAPORATION

    Science.gov (United States)

    The report gives results of a heat transfer evaluation of the refrigerants hexafluoropropane (HFC-236ea) and 1,1,2,2-dichloro-tetrafluoroethane (CFC-114). (NOTE: With the mandatory phase-out of chlorofluorocarbons (CFCs), as dictated by the Montreal Protocol and Clean Air Act Ame...

  13. Early Parenting and the Development of Externalizing Behavior Problems: Longitudinal Mediation Through Children's Executive Function.

    Science.gov (United States)

    Sulik, Michael J; Blair, Clancy; Mills-Koonce, Roger; Berry, Daniel; Greenberg, Mark

    2015-01-01

    Path analysis was used to investigate the longitudinal associations among parenting and children's executive function and externalizing behavior problems from 36 to 90 months of age in the Family Life Project (N = 1,115), a study of child development in the context of rural poverty. While controlling for stability in the constructs, semistructured observations of parenting prospectively predicted performance on a battery of executive function tasks and primary caregivers' reports of externalizing behavior. Furthermore, the association between early parenting and later externalizing behavior was longitudinally mediated by executive function, providing support for a process model in which sensitive parenting promotes children's self-regulation, which in turn reduces children's externalizing behavior. © 2015 The Authors. Child Development © 2015 Society for Research in Child Development, Inc.

  14. Testing of an automated online EA-IRMS method for fast and simultaneous carbon content and stable isotope measurement of aerosol samples

    Science.gov (United States)

    Major, István; Gyökös, Brigitta; Túri, Marianna; Futó, István; Filep, Ágnes; Hoffer, András; Molnár, Mihály

    2016-04-01

    Comprehensive atmospheric studies have demonstrated that carbonaceous aerosol is one of the main components of atmospheric particulate matter over Europe. Various methods, considering optical or thermal properties, have been developed for quantification of the accurate amount of both organic and elemental carbon constituents of atmospheric aerosol. The aim of our work was to develop an alternative fast and easy method for determination of the total carbon content of individual aerosol samples collected on prebaked quartz filters whereby the mass and surface concentration becomes simply computable. We applied the conventional "elemental analyzer (EA) coupled online with an isotope ratio mass spectrometer (IRMS)" technique which is ubiquitously used in mass spectrometry. Using this technique we are able to measure simultaneously the carbon stable isotope ratio of the samples, as well. During the developing process, we compared the EA-IRMS technique with an off-line catalytic combustion method worked out previously at Hertelendi Laboratory of Environmental Studies (HEKAL). We tested the combined online total carbon content and stable isotope ratio measurement both on standard materials and real aerosol samples. Regarding the test results the novel method assures, on the one hand, at least 95% of carbon recovery yield in a broad total carbon mass range (between 100 and 3000 ug) and, on the other hand, a good reproducibility of stable isotope measurements with an uncertainty of ± 0.2 per mill. Comparing the total carbon results obtained by the EA-IRMS and the off-line catalytic combustion method we found a very good correlation (R2=0.94) that proves the applicability of both preparation method. Advantages of the novel method are the fast and simplified sample preparation steps and the fully automated, simultaneous carbon stable isotope ratio measurement processes. Furthermore stable isotope ratio results can effectively be applied in the source apportionment

  15. Positive parenting predicts the development of adolescent brain structure: a longitudinal study.

    Science.gov (United States)

    Whittle, Sarah; Simmons, Julian G; Dennison, Meg; Vijayakumar, Nandita; Schwartz, Orli; Yap, Marie B H; Sheeber, Lisa; Allen, Nicholas B

    2014-04-01

    Little work has been conducted that examines the effects of positive environmental experiences on brain development to date. The aim of this study was to prospectively investigate the effects of positive (warm and supportive) maternal behavior on structural brain development during adolescence, using longitudinal structural MRI. Participants were 188 (92 female) adolescents, who were part of a longitudinal adolescent development study that involved mother-adolescent interactions and MRI scans at approximately 12 years old, and follow-up MRI scans approximately 4 years later. FreeSurfer software was used to estimate the volume of limbic-striatal regions (amygdala, hippocampus, caudate, putamen, pallidum, and nucleus accumbens) and the thickness of prefrontal regions (anterior cingulate and orbitofrontal cortices) across both time points. Higher frequency of positive maternal behavior during the interactions predicted attenuated volumetric growth in the right amygdala, and accelerated cortical thinning in the right anterior cingulate (males only) and left and right orbitofrontal cortices, between baseline and follow up. These results have implications for understanding the biological mediators of risk and protective factors for mental disorders that have onset during adolescence. Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. Software development for subsonic aircraft’s unsteady longitudinal stability derivatives calculation

    Directory of Open Access Journals (Sweden)

    Maričić Nikola

    2005-01-01

    Full Text Available Subsonic general configuration aircrafts’ unsteady longitudinal aerodynamic stability derivatives can be estimated using finite element methodology based on the Doublet Lattice Method (DLM, the Slender Body Theory (SBT and the Method of Images (MI. Applying this methodology, software DERIV is developed. The obtained results from DERIV are compared to NASTRAN examples HA21A and HA75H. A good agreement is achieved.

  17. Proyecto de Obras de Urbanización de la UD-EA1 Tm Murcia

    OpenAIRE

    Lafuente Pérez, Antonio

    2016-01-01

    El presente proyecto tiene por objeto la construcción de las obras de urbanización (viales, zonas verdes y servicios de abastecimiento y saneamiento) de la UD-EA1 del PGOUM. Escuela de Ingeniería de Caminos y Minas Universidad Politécnica de Cartagena

  18. E+A Galaxy Properties and Post-Starburst Galaxy Evolution Data through SDSS-IV MaNGA and Illustris: A Co-Analysis

    Science.gov (United States)

    Ojanen, Winonah; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Johnson, Amalya; Kerrison, Nicole; Marinelli, Mariarosa; Melchert, Nancy; Liu, Charles; Sloan Collaboration, SDSS-IV MaNGA

    2018-01-01

    E+A galaxies (Elliptical + A-type stars) are post-starburst galaxies that have experienced a sudden quenching phase. Using previous research methods, 39 candidates out of 2,812 galaxies observed, or 1.4%, were selected from the SDSS-IV MaNGA survey. We then identified morphological characteristics of the 39 galaxies including stellar kinematics, Gini coefficient, gas density and distribution and stellar ages. To study the origin of how E+A galaxies evolved to their present state, galaxy simulation data from the Illustris simulation was utilized to identify similar quenched post-starburst candidates. Seven post-starburst candidates were identified through star formation rate histories of Illustris simulated galaxies. The evolution of these galaxies is studied from 0 to 13.8 billion years ago to identify what caused the starburst and quenching of the Illustris candidates. Similar morphological characteristics of Illustris post-starburst candidates are pulled from before, during, and post-starburst and compared to the same morphological characteristics of the E+A galaxies from SDSS-IV MaNGA. The characteristics and properties of the Illustris galaxies are used to identify the possible evolutionary histories of the observed E+A galaxies. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  19. Longitudinal motor development of "apparently normal" high-risk infants at 18 months, 3 and 5 years.

    Science.gov (United States)

    Goyen, Traci Anne; Lui, Kei

    2002-12-01

    Motor development appears to be more affected by premature birth than other developmental domains, however few studies have specifically investigated the development of gross and fine motor skills in this population. To examine longitudinal motor development in a group of "apparently normal" high-risk infants. Developmental follow-up clinic in a perinatal centre. Longitudinal observational cohort study. Fifty-eight infants born less than 29 weeks gestation and/or 1000 g and without disabilities detected at 12 months. Longitudinal gross and fine motor skills at 18 months, 3 and 5 years using the Peabody Developmental Motor Scales. The HOME scale provided information of the home environment as a stimulus for development. A large proportion (54% at 18 months, 47% at 3 years and 64% at 5 years) of children continued to have fine motor deficits from 18 months to 5 years. The proportion of infants with gross motor deficits significantly increased over this period (14%, 33% and 81%, pmotor development was positively influenced by the quality of the home environment. A large proportion of high-risk infants continued to have fine motor deficits, reflecting an underlying problem with fine motor skills. The proportion of infants with gross motor deficits significantly increased, as test demands became more challenging. In addition, the development of gross and fine motor skills appears to be influenced differently by the home environment.

  20. The cosmic ray proton, helium and CNO fluxes in the 100 TeV energy region from TeV muons and EAS atmospheric Cherenkov light observations of MACRO and EAS-TOP

    CERN Document Server

    Aglietta, M; Ambrosio, M; Antolini, R; Antonioli, P; Arneodo, F; Baldini, A; Barbarino, G C; Barish, B C; Battistoni, G; Becherini, Y; Bellotti, R; Bemporad, C; Bergamasco, L; Bernardini, P; Bertaina, M; Bilokon, H; Bower, C; Brigida, M; Bussino, S; Cafagna, F; Calicchio, M; Campana, D; Carboni, M; Caruso, R; Castagnoli, C; Castellina, A; Cecchini, S; Cei, F; Chiarella, V; Chiarusi, T; Chiavassa, A; Choudhary, B C; Cini, G; Coutu, S; Cozzi, M; De Cataldo, G; De Marzo, C; De Mitri, I; De Vincenzi, M; Dekhissi, H; Derkaoui, J; Di Credico, A; Di Sciascio, G; Erriquez, O; Favuzzi, C; Forti, C; Fulgione, W; Fusco, P; Galeotti, P; Ghia, P L; Giacomelli, G; Giannini, G; Giglietto, N; Giorgini, M; Grassi, M; Grillo, A; Guarino, F; Gustavino, C; Habig, A; Hanson, K; Heinz, R; Iacovacci, M; Iarocci, E; Katsavounidis, E; Katsavounidis, I; Kearns, E; Kim, H; Kyriazopoulou, S; Lamanna, E; Lane, C; Levin, D S; Lipari, P; Longley, N P; Longo, M J; Loparco, F; Maaroufi, F; Mancarella, G; Mandrioli, G; Mannocchi, G; Margiotta, A; Marini, A; Martello, D; Marzari-Chiesa, A; Mazziotta, M N; Michael, D G; Monacelli, P; Montaruli, T; Monteno, M; Morello, C; Mufson, S; Musser, J; Navarra, G; Nicolò, D; Nolty, R; Orth, C; Osteria, G; Palamara, O; Patera, V; Patrizii, L; Pazzi, R; Peck, C W; Perrone, L; Petrera, S; D'Ettorre-Piazzoli, B; Popa, V; Rainó, A; Reynoldson, J; Ronga, F; Saavedra, O; Satriano, C; Scapparone, E; Scholberg, K; Sciubba, A; Sioli, M; Sirri, G; Sitta, M; Spinelli, P; Spinetti, M; Spurio, M; Stamerra, A; Steinberg, R; Stone, J L; Sulak, L R; Surdo, A; Tarle, G; Togo, V; Trinchero, G C; Vakili, M; Valchierotti, S; Vallania, P; Vernetto, S; Vigorito, C; Walter, C W; Webb, R; 10.1016/j.astropartphys.2004.01.005

    2004-01-01

    The primary cosmic ray (CR) proton, helium and CNO fluxes in the energy range 80-300 TeV are studied at the National Gran Sasso Laboratories by means of EAS-TOP (Campo Imperatore, 2005 m a.s.l.) and MACRO (deep underground, 3100 m w.e., the surface energy threshold for a muon reaching the detector being E/sub mu //sup th/ approximately=1.3 TeV). The measurement is based on: (a) the selection of primaries based on their energy/nucleon (i.e., with energy/nucleon sufficient to produce a muon with energy larger than 1.3 TeV) and the reconstruction of the shower geometry by means of the muons recorded by MACRO in the deep underground laboratories; (b) the detection of the associated atmospheric Cherenkov light (C.l.) signals by means of the C.l. detector of EAS-TOP. The C.l. density at core distance r>100 m is directly related to the total primary energy E/sub 0/. Proton and helium ("p+He") and proton, helium and CNO ("p +He+CNO") primaries are thus selected at E/sub 0/ approximately=80 Te V, and at E/sub 0/ appro...

  1. Developing Enterprise Architecture Skills: A Developing Country Perspective

    OpenAIRE

    Shaanika , Irja; Iyamu , Tiko

    2014-01-01

    Part 1: Key Competencies for Educating ICT Professionals; International audience; Through different approaches, organisations strive to evolve their competitiveness, as well as their addressing their operational and strategic needs. Some organisations employ Enterprise Architecture (EA), to bridge the gap between the business and IT, and to providing strategic goals. However, there exists scarcity of EA Skills in many developing countries. This could be attributed to the uniqueness of the dis...

  2. Development of an automated desktop procedure for defining macro-reaches for river longitudinal profiles

    CSIR Research Space (South Africa)

    Dollar, LH

    2006-07-01

    Full Text Available This paper presents an automated desktop procedure for delineating river longitudinal profiles into macro-reaches for use in Ecological Reserve assessments and to aid freshwater ecosystem conservation planning. The procedure was developed for use...

  3. Oxygen isotope analysis of phosphate: improved precision using TC/EA CF-IRMS.

    Science.gov (United States)

    LaPorte, D F; Holmden, C; Patterson, W P; Prokopiuk, T; Eglington, B M

    2009-06-01

    Oxygen isotope values of biogenic apatite have long demonstrated considerable promise for paleothermometry potential because of the abundance of material in the fossil record and greater resistance of apatite to diagenesis compared to carbonate. Unfortunately, this promise has not been fully realized because of relatively poor precision of isotopic measurements, and exceedingly small size of some substrates for analysis. Building on previous work, we demonstrate that it is possible to improve precision of delta18O(PO4) measurements using a 'reverse-plumbed' thermal conversion elemental analyzer (TC/EA) coupled to a continuous flow isotope ratio mass spectrometer (CF-IRMS) via a helium stream [Correction made here after initial online publication]. This modification to the flow of helium through the TC/EA, and careful location of the packing of glassy carbon fragments relative to the hot spot in the reactor, leads to narrower, more symmetrically distributed CO elution peaks with diminished tailing. In addition, we describe our apatite purification chemistry that uses nitric acid and cation exchange resin. Purification chemistry is optimized for processing small samples, minimizing isotopic fractionation of PO4(-3) and permitting Ca, Sr and Nd to be eluted and purified further for the measurement of delta44Ca and 87Sr/86Sr in modern biogenic apatite and 143Nd/144Nd in fossil apatite. Our methodology yields an external precision of +/- 0.15 per thousand (1sigma) for delta18O(PO4). The uncertainty is related to the preparation of the Ag3PO4 salt, conversion to CO gas in a reversed-plumbed TC/EA, analysis of oxygen isotopes using a CF-IRMS, and uncertainty in constructing calibration lines that convert raw delta18O data to the VSMOW scale. Matrix matching of samples and standards for the purpose of calibration to the VSMOW scale was determined to be unnecessary. Our method requires only slightly modified equipment that is widely available. This fact, and the

  4. Letramentos acadêmicos e multimodalidade em contexto de EaD semipresencial

    OpenAIRE

    Komesu, Fabiana

    2012-01-01

    De uma perspectiva teórica enunciativo-discursiva, este artigo tem como objetivo discutir o processo de constituição do texto em contexto digital, de maneira particularizada, por meio da problematização de modos e recursos semióticos atualizados na produção acadêmica do universitário que utiliza computador com acesso à internet no processo de Educação a Distância (EaD) semipresencial. Interessa investigar como o modelo de letramentos acadêmicos pode ser articulado ao estudo da multimodalidade...

  5. Longitudinal charge nurse leadership development and evaluation.

    Science.gov (United States)

    Krugman, Mary; Heggem, Laura; Kinney, Lisa Judd; Frueh, Margaret

    2013-09-01

    The study's aim was to examine longitudinal outcomes of a leadership program for permanent and relief charge nurse from 1996 to 2012 using action research and Kouzes and Posner's The Leadership Challenge conceptual frameworks. Charge nurses hold significant oversight of patient safety, quality, and team functioning. This study contributes knowledge regarding charge nurse leadership and organization outcomes associated with these essential roles over time. Data were collected over 6 time periods using Kouzes and Posner's The Leadership Practices Inventory (LPI) and internally developed action research tools. Surveys were aligned with leadership and work environment changes to examine outcomes. Charge nurse leadership LPI mean ratings improved. Relief charge nurses reached similar LPI outcomes by 2012, with no statistical differences in mean or domain scores. Action research methods facilitated executive decision making during change processes. Demographics shifted with younger charge nurses with less practice experience serving as charge nurses in the most recent years. Charge nurse leadership reported significant gains despite institutional changes and uneven delivery of educational interventions.

  6. Maternal Weight Predicts Children's Psychosocial Development via Parenting Stress and Emotional Availability

    Science.gov (United States)

    Bergmann, Sarah; Schlesier-Michel, Andrea; Wendt, Verena; Grube, Matthias; Keitel-Korndörfer, Anja; Gausche, Ruth; von Klitzing, Kai; Klein, Annette M.

    2016-01-01

    Introduction: Maternal obesity has been shown to be a risk factor for obesity in children and may also affect children's psychosocial outcomes. It is not yet clear whether there are also psycho-emotional mechanisms explaining the effects of maternal weight on young children's weight and psychosocial development. We aimed to evaluate whether maternal body mass index (BMI), mother–child emotional availability (EA), and maternal parenting stress are associated with children's weight and psychosocial development (i.e., internalizing/externalizing symptoms and social competence) and whether these predictors interact with each other. Methods: This longitudinal study included three assessment points (~11 months apart). The baseline sample consisted of N = 194 mothers and their children aged 5–47 months (M = 28.18, SD = 8.44, 99 girls). At t1, we measured maternal weight and height to calculate maternal BMI. We videotaped mother–child interactions, coding them with the EA Scales (fourth edition). We assessed maternal parenting stress with the Parenting Stress Index (PSI) short form. At t1 to t3, we measured height and weight of children and calculated BMI–SDS scores. Children's externalizing and internalizing problems (t1–t3) and social competence (t3, N = 118) were assessed using questionnaires: Child Behavior Checklist (CBCL 1.5–5), Strengths and Difficulties Questionnaire (SDQ: prosocial behavior), and a checklist for behavioral problems at preschool age (VBV 3–6: social-emotional competence). Results: By applying structural equation modeling (SEM) and a latent regression analysis, we found maternal BMI to predict higher BMI–SDS and a poorer psychosocial development (higher externalizing symptoms, lower social competence) in children. Higher parenting stress predicted higher levels of externalizing and internalizing symptoms and lower social competence. Better maternal EA was associated with higher social competence. We found parenting stress to serve as

  7. Characterization of the Defense Waste Processing Facility (DWPF) Environmental Assessment (EA) glass Standard Reference Material. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Jantzen, C.M.; Bibler, N.E.; Beam, D.C.; Crawford, C.L.; Pickett, M.A.

    1993-06-01

    Liquid high-level nuclear waste at the Savannah River Site (SRS) will be immobilized by vitrification in borosilicate glass. The glass will be produced and poured into stainless steel canisters in the Defense Waste Processing Facility (DWPF). Other waste form producers, such as West Valley Nuclear Services (WVNS) and the Hanford Waste Vitrification Project (HWVP), will also immobilize high-level radioactive waste in borosilicate glass. The canistered waste will be stored temporarily at each facility for eventual permanent disposal in a geologic repository. The Department of Energy has defined a set of requirements for the canistered waste forms, the Waste Acceptance Product Specifications (WAPS). The current Waste Acceptance Primary Specification (WAPS) 1.3, the product consistency specification, requires the waste form producers to demonstrate control of the consistency of the final waste form using a crushed glass durability test, the Product Consistency Test (PCI). In order to be acceptable, a waste glass must be more durable during PCT analysis than the waste glass identified in the DWPF Environmental Assessment (EA). In order to supply all the waste form producers with the same standard benchmark glass, 1000 pounds of the EA glass was fabricated. The chemical analyses and characterization of the benchmark EA glass are reported. This material is now available to act as a durability and/or redox Standard Reference Material (SRM) for all waste form producers.

  8. Design and research on nuclear power plant EAS jet pump

    International Nuclear Information System (INIS)

    Chen Xingjiang; Fang Xiquan; Xie Jian; Yang Bin; Wang Xueling; Qi Yanli

    2014-01-01

    The jet pump is an important part of the PWR containment spray system. It will be performed the security functions under the accident conditions, which the containment spray system adds the right amount of sodium hydroxide through the jet pump to spray water. This paper describes the principle of jet pump. And the optimum structure dimensions were calculated according to the performance parameter and requirement of the jet pump. On the basis of foreign EAS jet pump design experience, the structure dimensions were modified according to the CFD analysis and performance test. Finally, the results of CFD analysis and performance test were provided. (authors)

  9. Automatic and integrated micro-enzyme assay (AIμEA) platform for highly sensitive thrombin analysis via an engineered fluorescence protein-functionalized monolithic capillary column.

    Science.gov (United States)

    Lin, Lihua; Liu, Shengquan; Nie, Zhou; Chen, Yingzhuang; Lei, Chunyang; Wang, Zhen; Yin, Chao; Hu, Huiping; Huang, Yan; Yao, Shouzhuo

    2015-04-21

    Nowadays, large-scale screening for enzyme discovery, engineering, and drug discovery processes require simple, fast, and sensitive enzyme activity assay platforms with high integration and potential for high-throughput detection. Herein, a novel automatic and integrated micro-enzyme assay (AIμEA) platform was proposed based on a unique microreaction system fabricated by a engineered green fluorescence protein (GFP)-functionalized monolithic capillary column, with thrombin as an example. The recombinant GFP probe was rationally engineered to possess a His-tag and a substrate sequence of thrombin, which enable it to be immobilized on the monolith via metal affinity binding, and to be released after thrombin digestion. Combined with capillary electrophoresis-laser-induced fluorescence (CE-LIF), all the procedures, including thrombin injection, online enzymatic digestion in the microreaction system, and label-free detection of the released GFP, were integrated in a single electrophoretic process. By taking advantage of the ultrahigh loading capacity of the AIμEA platform and the CE automatic programming setup, one microreaction column was sufficient for many times digestion without replacement. The novel microreaction system showed significantly enhanced catalytic efficiency, about 30 fold higher than that of the equivalent bulk reaction. Accordingly, the AIμEA platform was highly sensitive with a limit of detection down to 1 pM of thrombin. Moreover, the AIμEA platform was robust and reliable to detect thrombin in human serum samples and its inhibition by hirudin. Hence, this AIμEA platform exhibits great potential for high-throughput analysis in future biological application, disease diagnostics, and drug screening.

  10. Utility of 64-row MDCT in assessment of neonates with congenital EA and distal TEF

    Directory of Open Access Journals (Sweden)

    Hosam El-Deen Galal Mohamed El-Malah

    2015-12-01

    Conclusion: Preoperative MDCT scan with MPVR, 3D TL-VR of 64-row MDCT which is a noninvasive technique could provide more accurate information about the assessment of the origin of the fistula, the distal esophageal pouches and inter-pouch distance in neonates with EA and distal TEF.

  11. Reading in dyslexia across literacy development: A longitudinal study of effective connectivity.

    Science.gov (United States)

    Morken, Frøydis; Helland, Turid; Hugdahl, Kenneth; Specht, Karsten

    2017-01-01

    Dyslexia is a literacy disorder affecting the efficient acquisition of reading and writing skills. The disorder is neurobiological in origin. Due to its developmental nature, longitudinal studies of dyslexia are of essence. They are, however, relatively scarce. The present study took a longitudinal approach to cortical connectivity of brain imaging data in reading tasks in children with dyslexia and children with typical reading development. The participants were followed with repeated measurements through Pre-literacy (6 years old), Emergent Literacy (8 years old) and Literacy (12 years old) stages, using Dynamic Causal Modelling (DCM) when analysing functional magnetic resonance imaging (fMRI) data. Even though there are a few longitudinal studies on effective connectivity in typical reading, to our knowledge, no studies have previously investigated these issues in relation to dyslexia. We set up a model of a brain reading network involving five cortical regions (inferior frontal gyrus, precentral gyrus, superior temporal gyrus, inferior parietal lobule, and occipito-temporal cortex). Using DCM, connectivity measures were calculated for each connection in the model. These measures were further analysed using factorial ANOVA. The results showed that the difference between groups centred on connections going to and from the inferior frontal gyrus (two connections) and the occipito-temporal cortex (three connections). For all five connections, the typical group showed stable or decreasing connectivity measures. The dyslexia group, on the other hand, showed a marked up-regulation (occipito-temporal connections) or down-regulation (inferior frontal gyrus connections) from 6 years to 8 years, followed by normalization from 8 years to 12 years. We interpret this as a delay in the dyslexia group in developing into the Pre-literacy and Emergent literacy stages. This delay could possibly be detrimental to literacy development. By age 12, there was no statistically

  12. Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Enrique Gallego-Colon

    2015-01-01

    Full Text Available Strategies to limit damage and improve repair after myocardial infarct remain a major therapeutic goal in cardiology. Our previous studies have shown that constitutive expression of a locally acting insulin-like growth factor-1 Ea (IGF-1Ea propeptide promotes functional restoration after cardiac injury associated with decreased scar formation. In the current study, we investigated the underlying molecular and cellular mechanisms behind the enhanced functional recovery. We observed improved cardiac function in mice overexpressing cardiac-specific IGF-1Ea as early as day 7 after myocardial infarction. Analysis of gene transcription revealed that supplemental IGF-1Ea regulated expression of key metalloproteinases (MMP-2 and MMP-9, their inhibitors (TIMP-1 and TIMP-2, and collagen types (Col 1α1 and Col 1α3 in the first week after injury. Infiltration of inflammatory cells, which direct the remodelling process, was also altered; in particular there was a notable reduction in inflammatory Ly6C+ monocytes at day 3 and an increase in anti-inflammatory CD206+ macrophages at day 7. Taken together, these results indicate that the IGF-1Ea transgene shifts the balance of innate immune cell populations early after infarction, favouring a reduction in inflammatory myeloid cells. This correlates with reduced extracellular matrix remodelling and changes in collagen composition that may confer enhanced scar elasticity and improved cardiac function.

  13. Hours in non-parental child care are related to language development in a longitudinal cohort study

    NARCIS (Netherlands)

    Luijk, M.P.C.M.; Linting, M.; Henrichs, J.; Herba, C.M.; Verhage, M.L.; Schenk, J.J.; Arends, L.R.; Raat, H.; Jaddoe, V.W.V.; Hofman, A.; Verhulst, F.C.; Tiemeier, H.; Van IJzendoorn, M.H.

    2015-01-01

    Background: The effects of child care services on several domains of child development have been extensively investigated, but evidence regarding the effects of child care on language development remains inconclusive. Methods: Within a large-scale population-based study, we examined the longitudinal

  14. Development of Working Memory and Performance in Arithmetic: A Longitudinal Study with Children

    Science.gov (United States)

    López, Magdalena

    2014-01-01

    Introduction: This study has aimed to investigate the relationship between the development of working memory and performance on arithmetic activities. Method: We conducted a 3-year longitudinal study of a sample of 90 children, that was followed during the first, second and third year of primary school. All children were tested on measures of WM…

  15. HEAT TRANSFER EVALUATION OF HFC-236EA WITH HIGH PERFORMANCE ENHANCED TUBES IN CONDENSATION AND EVAPORATION

    Science.gov (United States)

    The report gives results of an evaluation of the heat transfer performance of pure hydrofluorocarbon (HFC)-236ea for high performance enhanced tubes which had not been previously used in Navy shipboard chillers. Shell-side heat transfer coefficient data are presented for condensa...

  16. Longitudinal Theory of Mind (ToM) Development From Preschool to Adolescence With and Without ToM Delay.

    Science.gov (United States)

    Peterson, Candida C; Wellman, Henry M

    2018-04-16

    Longitudinal tracking of 107 three- to-thirteen-year-olds in a cross-sequential design showed a 6-step theory of mind (ToM) sequence identified by a few past cross-sectional studies validly depicted longitudinal ToM development from early to middle childhood for typically developing (TD) children and those with ToM delays owing to deafness or autism. Substantively, all groups showed ToM progress throughout middle childhood. Atypical development was more extended and began and ended at lower levels than for TD children. Yet most children in all groups progressed over the study's mean 1.5 years. Findings help resolve theoretical debates about ToM development for children with and without delay and gain strength and weight via their applicability to three disparate groups varying in ToM timing and sequencing. © 2018 Society for Research in Child Development.

  17. Evaluation of RSDL, M291 SDK, 0.5 Bleach, 1% Soapy Water and SERPACWA: Part 11: Challenge with EA4243 (VR, Russian VX)

    Science.gov (United States)

    2016-01-01

    listed decontamination products in the haired guinea pig model following exposure to VR (Russian VX, EA4243). 15. SUBJECT TERMS decontamination...the efficacy of the barrier skin cream SERPACWA and the four listed decontamination products in the haired guinea pig model following exposure to VR...four listed decontamination products and SERPACWA in the haired guinea pig model following exposure to VR (Russian VX, EA4243, Soviet V-gas

  18. Assessing social-emotional development in children from a longitudinal perspective.

    Science.gov (United States)

    Denham, S A; Wyatt, T M; Bassett, H H; Echeverria, D; Knox, S S

    2009-01-01

    This paper provides an overview of methodological challenges related to the epidemiological assessment of social-emotional development in children. Because population-based studies involve large cohorts and are usually multicentre in structure, they have cost, participant burden and other specific issues that affect the feasibility of the types of measures that can be administered. Despite these challenges, accurate in-depth assessment of social-emotional functioning is crucial, based on its importance to child outcomes like mental health, academic performance, delinquency and substance abuse. Five dimensions of social-emotional development in children are defined: (1) social competence; (2) attachment; (3) emotional competence; (4) self-perceived competence; and (5) temperament/personality. Their measurement in a longitudinal study and associated challenges are discussed. Means of making valid, reliable assessments while at the same time minimising the multiple challenges posed in the epidemiological assessment of social-emotional development in children are reviewed.

  19. Limites e possibilidades do ensino à distância (EaD na educação permanente em saúde: revisão integrativa

    Directory of Open Access Journals (Sweden)

    Adriane das Neves Silva

    2015-04-01

    Full Text Available Trata-se de um estudo sobre o uso do ensino a distância (EaD como uma estratégia de ensino na educação permanente em saúde (EPS, que teve como objetivo identificar e analisar os limites e possibilidades do uso da EaD na EPS. Estudo de revisão integrativa. O resultado aponta que a EaD é uma estratégia inovadora possível e potencial para a EPS, facilitando o desenvolvimento da aprendizagem dentro ou fora da instituição de saúde, porém é evidente a escassez de pesquisas na área. As limitações para a realização dos programas estão relacionadas à variável tempo, preparação para lidar com as tecnologias e importância do tutor como facilitador da aprendizagem. Conclui-se que o uso da EaD tem tido uma importante contribuição para o desenvolvimento dos recursos humanos em saúde, seja no processo de formação e/ou no processo contínuo de conhecimento.

  20. EA-MC Neutronic Calculations on IAEA ADS Benchmark 3.2

    Energy Technology Data Exchange (ETDEWEB)

    Dahlfors, Marcus [Uppsala Univ. (Sweden). Dept. of Radiation Sciences; Kadi, Yacine [CERN, Geneva (Switzerland). Emerging Energy Technologies

    2006-01-15

    The neutronics and the transmutation properties of the IAEA ADS benchmark 3.2 setup, the 'Yalina' experiment or ISTC project B-70, have been studied through an extensive amount of 3-D Monte Carlo calculations at CERN. The simulations were performed with the state-of-the-art computer code package EA-MC, developed at CERN. The calculational approach is outlined and the results are presented in accordance with the guidelines given in the benchmark description. A variety of experimental conditions and parameters are examined; three different fuel rod configurations and three types of neutron sources are applied to the system. Reactivity change effects introduced by removal of fuel rods in both central and peripheral positions are also computed. Irradiation samples located in a total of 8 geometrical positions are examined. Calculations of capture reaction rates in {sup 129}I, {sup 237}Np and {sup 243}Am samples and of fission reaction rates in {sup 235}U, {sup 237}Np and {sup 243}Am samples are presented. Simulated neutron flux densities and energy spectra as well as spectral indices inside experimental channels are also given according to benchmark specifications. Two different nuclear data libraries, JAR-95 and JENDL-3.2, are applied for the calculations.

  1. 85 km long reach PON system using a reflective SOA-EA modulator and distributed Raman fiber amplification

    NARCIS (Netherlands)

    Tafur Monroy, I.; Öhman, F.; Yvind, K.; Kjaer, R.; Peucheret, C.; Koonen, A.M.J.; Jeppesen, P.

    2006-01-01

    We report on a bidirectional 85 km long reach PON system supported by distributed fiber Raman amplification with a record 7.5 Gb/s remote carrier modulated upstream signal by employing a reflective SOA-EA monolithically integrated circuit.

  2. Managing Innovation and Business Development Using Enterprise Architecture

    DEFF Research Database (Denmark)

    Tambo, Torben; Bækgaard, Lars

    2011-01-01

    technologies. In management of IT, it has become increasingly popular to use Enterprise Architecture (EA) as a method and supported by a series of formal frameworks. EA maps artifacts and motives against the business strategy. In this paper, MOT and EA are reviewed for their mutual potentials and issues. Two...... of well planned technological changes. Management of technology (MOT) addresses identification, selection, (long term) planning, designing, implementation and operation of technology based business development. Information Technology (IT) is a key enabler for a vast range of contemporary corporate...... case studies illustrate how enterprises can make major changes derived from business strategy observing both MOT and EA. This suggests a combined view inspired from the IT business’ dedication to EA using EA’s formalisms and the management orientation of MOT to improve understanding technological...

  3. A simulation study of Linsley's approach to infer elongation rate and fluctuations of the EAS maximum depth from muon arrival time distributions

    International Nuclear Information System (INIS)

    Badea, A.F.; Brancus, I.M.; Rebel, H.; Haungs, A.; Oehlschlaeger, J.; Zazyan, M.

    1999-01-01

    The average depth of the maximum X m of the EAS (Extensive Air Shower) development depends on the energy E 0 and the mass of the primary particle, and its dependence from the energy is traditionally expressed by the so-called elongation rate D e defined as change in the average depth of the maximum per decade of E 0 i.e. D e = dX m /dlog 10 E 0 . Invoking the superposition model approximation i.e. assuming that a heavy primary (A) has the same shower elongation rate like a proton, but scaled with energies E 0 /A, one can write X m = X init + D e log 10 (E 0 /A). In 1977 an indirect approach studying D e has been suggested by Linsley. This approach can be applied to shower parameters which do not depend explicitly on the energy of the primary particle, but do depend on the depth of observation X and on the depth X m of shower maximum. The distribution of the EAS muon arrival times, measured at a certain observation level relatively to the arrival time of the shower core reflect the pathlength distribution of the muon travel from locus of production (near the axis) to the observation locus. The basic a priori assumption is that we can associate the mean value or median T of the time distribution to the height of the EAS maximum X m , and that we can express T = f(X,X m ). In order to derive from the energy variation of the arrival time quantities information about elongation rate, some knowledge is required about F i.e. F = - ∂ T/∂X m ) X /∂(T/∂X) X m , in addition to the variations with the depth of observation and the zenith-angle (θ) dependence, respectively. Thus ∂T/∂log 10 E 0 | X = - F·D e ·1/X v ·∂T/∂secθ| E 0 . In a similar way the fluctuations σ(X m ) of X m may be related to the fluctuations σ(T) of T i.e. σ(T) = - σ(X m )· F σ ·1/X v ·∂T/∂secθ| E 0 , with F σ being the corresponding scaling factor for the fluctuation of F. By simulations of the EAS development using the Monte Carlo code CORSIKA the energy and angle

  4. Crack closure in near-threshold fatigue crack propagation in railway axle steel EA4T

    Czech Academy of Sciences Publication Activity Database

    Pokorný, Pavel; Vojtek, Tomáš; Náhlík, Luboš; Hutař, Pavel

    2017-01-01

    Roč. 185, NOV (2017), s. 2-19 ISSN 0013-7944 R&D Projects: GA MŠk(CZ) LQ1601 Institutional support: RVO:68081723 Keywords : Fatigue crack propagation * crack closure * EA4T * Railway axle Subject RIV: JL - Materials Fatigue, Friction Mechanics OBOR OECD: Audio engineering , reliability analysis Impact factor: 2.151, year: 2016

  5. 77 FR 33972 - Channel Spacing and Bandwidth Limitations for Certain Economic Area (EA)-based 800 MHz...

    Science.gov (United States)

    2012-06-08

    ..., 445 12th Street SW., Washington, DC 20554. The complete text may be purchased from the Commission's... regulatory parity between commercial wireless licensees, to consumers' benefit. Under this rule change, EA... begin, the specific locations of antenna sites, and effective radiated power (ERP) for each antenna site...

  6. A Qualitative Evaluation of Contact Centre Dietitian Support and Electronic Motivational Messaging for eaTracker My Goals Users.

    Science.gov (United States)

    Lieffers, Jessica R L; Haresign, Helen; Mehling, Christine; Arocha, Jose F; Hanning, Rhona M

    2018-06-01

    To conduct a qualitative evaluation of adjunct supports (brief motivational messaging regarding goals delivered by email/website, contact centre dietitian assistance) offered by EatRight Ontario (ERO) for users of a website-based nutrition/activity goal setting/tracking feature (eaTracker "My Goals"). One-on-one semi-structured interviews were conducted with My Goals users in Ontario (n = 18) and Alberta (n = 5) recruited via the eaTracker website and ERO contact centre dietitians (n = 5). Interview transcripts were analyzed using content analysis. Participants had mixed experiences and perspectives with ERO motivational messaging. Messages targeted towards specific goals (e.g., tips, recipes) were generally well-liked, and generic messages (e.g., eaTracker login reminders) were less useful. No interviewed users had contacted ERO dietitians regarding goals, and dietitians reported encountering few callers asking for assistance while using My Goals. Limited user knowledge was one explanation for this finding. Participants provided suggestions to enhance these supports. Electronic motivational messaging and contact centre dietitian assistance have the potential to support achievement of goals set with website-based features. When considering using electronic messaging, researchers and practitioners should consider message content and delivery tailoring. Marketing that focuses on how contact centre dietitians can assist website users with their goals is needed when services are used in naturalistic settings.

  7. Longitudinal interrelationships between frequent geographic relocation and personality development: results from the Amsterdam Growth and Health Longitudinal Study.

    Science.gov (United States)

    Lin, Kuan-Chia; Twisk, Jos W R; Rong, Jiin-Ru

    2011-04-01

    This study is part of the Amsterdam Growth and Health Longitudinal Study, which was undertaken to assess the long-term interrelationships between cumulative frequency of geographic relocation (CFGR) and the development of personality characteristics (i.e., Inadequacy, Rigidity, Social Inadequacy, Dominance, Self-sufficiency, Self-esteem, and Hostility). We found that participants who had more mobility experiences had lower consistency in their personality characteristics (the exception being Rigidity). Residential mobility from different life stages was positively associated with the continuity and change of Inadequacy and Dominance. In addition, young adults with higher Rigidity personality experienced fewer geographic moves during the transition from young adulthood to mid-life. Our study provides evidence that CFGR in different life stages may be associated with the development of personality characteristics from young adulthood to mid-life in different ways. Increased awareness of the potential interrelationships between frequent geographic relocation and personality development may have positive consequences for adult psychological health. © 2011 American Orthopsychiatric Association.

  8. Longitudinal development of number line estimation and mathematics performance in primary school children.

    Science.gov (United States)

    Friso-van den Bos, Ilona; Kroesbergen, Evelyn H; Van Luit, Johannes E H; Xenidou-Dervou, Iro; Jonkman, Lisa M; Van der Schoot, Menno; Van Lieshout, Ernest C D M

    2015-06-01

    Children's ability to relate number to a continuous quantity abstraction visualized as a number line is widely accepted to be predictive of mathematics achievement. However, a debate has emerged with respect to how children's placements are distributed on this number line across development. In the current study, different models were applied to children's longitudinal number placement data to get more insight into the development of number line representations in kindergarten and early primary school years. In addition, longitudinal developmental relations between number line placements and mathematical achievement, measured with a national test of mathematics, were investigated using cross-lagged panel modeling. A group of 442 children participated in a 3-year longitudinal study (ages 5-8 years) in which they completed a number-to-position task every 6 months. Individual number line placements were fitted to various models, of which a one-anchor power model provided the best fit for many of the placements at a younger age (5 or 6 years) and a two-anchor power model provided better fit for many of the children at an older age (7 or 8 years). The number of children who made linear placements also grew with age. Cross-lagged panel analyses indicated that the best fit was provided with a model in which number line acuity and mathematics performance were mutually predictive of each other rather than models in which one ability predicted the other in a non-reciprocal way. This indicates that number line acuity should not be seen as a predictor of math but that both skills influence each other during the developmental process. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Dynamical aspects of violent collisions in Ar + Ag reactions at E/A = 27 MeV

    International Nuclear Information System (INIS)

    Rivet, M.F.; Borderie, B.; Jouan, D.; Remaud, B.

    1988-01-01

    Intermediate-mass fragment studies were found to give an overview of the mechanisms involved in violent collisions between Ar and Ag at E/A = 27 MeV. A comparison is made with semi-classical calculations (Landau-Vlasov) which reproduce experimental observations well and sustain the persistence of dissipative processes at high incident relative velocity (∼ 0.2c)

  10. 33 CFR 230.7 - Actions normally requiring an Environmental Assessment (EA) but not necessarily an EIS.

    Science.gov (United States)

    2010-07-01

    .... (d) Construction and Operations and Maintenance. Changes in environmental impacts which were not considered in the project EIS or EA. Examples are changes in pool level operations, use of new disposal areas, location of bank protection works, etc. (e) Real Estate Management and Disposal Actions. (1) Disposal of a...

  11. Development of a longitudinal integrated clerkship at an academic medical center.

    Science.gov (United States)

    Poncelet, Ann; Bokser, Seth; Calton, Brook; Hauer, Karen E; Kirsch, Heidi; Jones, Tracey; Lai, Cindy J; Mazotti, Lindsay; Shore, William; Teherani, Arianne; Tong, Lowell; Wamsley, Maria; Robertson, Patricia

    2011-04-04

    In 2005, medical educators at the University of California, San Francisco (UCSF), began developing the Parnassus Integrated Student Clinical Experiences (PISCES) program, a year-long longitudinal integrated clerkship at its academic medical center. The principles guiding this new clerkship were continuity with faculty preceptors, patients, and peers; a developmentally progressive curriculum with an emphasis on interdisciplinary teaching; and exposure to undiagnosed illness in acute and chronic care settings. Innovative elements included quarterly student evaluation sessions with all preceptors together, peer-to-peer evaluation, and oversight advising with an assigned faculty member. PISCES launched with eight medical students for the 2007/2008 academic year and expanded to 15 students for 2008/2009. Compared to UCSF's traditional core clerkships, evaluations from PISCES indicated significantly higher student satisfaction with faculty teaching, formal didactics, direct observation of clinical skills, and feedback. Student performance on discipline-specific examinations and United States Medical Licensing Examination step 2 CK was equivalent to and on standardized patient examinations was slightly superior to that of traditional peers. Participants' career interests ranged from primary care to surgical subspecialties. These results demonstrate that a longitudinal integrated clerkship can be implemented successfully at a tertiary care academic medical center.

  12. Exogenous vs Endogenous Growth in the EU’s EaP and Central Asian Countries

    Directory of Open Access Journals (Sweden)

    Sharipov Ilkhom

    2016-12-01

    Full Text Available The main purpose of this paper is to determine and analyse the factors that affected economic growth in the EU’s Eastern Partnership and Central Asian countries in the 2000-2015 period. Economic growth is one of the main targets of economic policy of any country and influenced by various determinants. Of particular interest is the endogenous and exogenous nature of these factors. Having classified these factors into exogenous and endogenous ones, we examined and determined the significance and robustness of various factors influencing the economic growth in these countries, like investment, human capital, research and development, economic policies and macroeconomic conditions, openness to trade, geography, political factors and others. Correlation and factor analysis showed significance and strong association of GDP per capita with physical, human capital, and R&D in EaP countries and with natural resources and active population share in Central Asian countries.

  13. Intellectual development in Noonan syndrome: a longitudinal study.

    Science.gov (United States)

    Roelofs, Renée L; Janssen, Nikki; Wingbermühle, Ellen; Kessels, Roy P C; Egger, Jos I M

    2016-07-01

    Although cognitive impairments in adults with Noonan syndrome seem to be limited to a low-average intelligence and slower processing speed, studies in children with Noonan syndrome have demonstrated more extensive cognitive problems. These include deficits in language skills, memory, attention, and executive functioning. This longitudinal study is the first to investigate intellectual development in a group of individuals with Noonan syndrome. Sixteen patients with Noonan syndrome underwent intelligence assessment both in childhood and in adulthood, using Wechsler's intelligence scales. IQ scores and Wechsler standard scores achieved in childhood and adulthood were compared. Subsequently, verbal and performance IQ in childhood were used as predictors for adult IQ and index scores. Compared with childhood scores, adult full-scale IQ and performance IQ significantly increased. Adult performance IQ was higher than verbal IQ. Childhood performance IQ and verbal IQ together predicted all adult IQ and index scores, except for the processing speed index. Childhood IQ was a significant predictor of adult intelligence in patients with Noonan syndrome. Performance IQ advanced to a normal level in adulthood, while verbal IQ did not develop proportionately, resulting in a discrepancy between adult performance IQ and verbal IQ. This finding could suggest a delay in the development of executive functioning in patients with Noonan syndrome, which seems to be outgrown in adulthood.

  14. Using longitudinal mixed methods to study the development of professional behaviours during pharmacy work-based training.

    Science.gov (United States)

    Jee, Samuel D; Schafheutle, Ellen I; Noyce, Peter R

    2017-05-01

    Recent longitudinal investigations of professional socialisation and development of professional behaviours during work-based training are lacking. Using longitudinal mixed methods, this study aimed to explore the development of professional behaviours during a year of intensive work-based (pre-registration) training in pharmacy. Twenty trainee pharmacists and their tutors completed semi-structured interview and professional behaviour questionnaires at four time points during 2011/2012: months 1, 4 and 9 during training and 4 months after registration; tutors participated in months 1 and 9. Interviews were analysed thematically using template analysis, and questionnaires were analysed using ANOVA and t-tests. Self-assessed (trainee) and tutor ratings of all elements of professional behaviours measured in questionnaires (appearance, interpersonal/social skills, responsibility, communication skills) increased significantly from the start of pre-registration training to post-registration. Some elements, for example, communication skills, showed more change over time compared with others, such as appearance, and continued to improve post-registration. Qualitative findings highlighted the changing roles of trainees and learning experiences that appeared to facilitate the development of professional behaviours. Trainees' colleagues, and particularly tutors, played an essential part in trainees' development through offering support and role modelling. Trainees noted that they would have benefited from more responsibilities during training to ease the transition into practising as a responsible pharmacist. Longitudinal mixed methods can unpack the way in which professional behaviours develop during work-based training and allow researchers to examine changes in the demonstration of professional behaviours and how they occur. Identifying areas less prone to change allows for more focus to be given to supporting trainees in areas where there is a development need, such as

  15. The Relationship between Early Language, Cognitive and Social Development through a Longitudinal Study of Autistic Children.

    Science.gov (United States)

    Ogura, Tamiko

    The development of and relationship between early language, symbolic play, sensorimotor skills, and social development were examined in a longitudinal study conducted in Japan with two young autistic males who were observed from the approximate ages of 2 to 4 years in clinic, day care, and home settings. One child acquired speech; the other did…

  16. Differentiation of partial acylglycerols derived from different animal fats by EA-IRMS and GCMS techniques

    Energy Technology Data Exchange (ETDEWEB)

    Nina Naquiah, A.N.; Marikkar, J.M.N.; Shuhaimi, M.

    2016-07-01

    A study was carried out to compare partial acylglycerols of lard with those of chicken fat, beef fat and mutton fat using Gas Chromatography Mass Spectrometry (GC-MS) and Elemental Analysis–Isotope Ratio Mass Spectrometry (EA-IRMS). Mono- (MAG) and di-(DAG) acylglycerols of animal fats were prepared according to a chemical glycerolysis method and isolated using column chromatography. The fatty acid composition and δ13C carbon isotope ratio of MAG and DAG derived from individual animal fat were determined separately to establish their identity characteristics. The results showed that the δ13C values of MAG and DAG of lard were significantly different from those of MAG and DAG derived from chicken fat, beef fat and mutton fat. According to the loading plots based on a principle component analysis (PCA), fatty acids namely stearic, oleic and linoleic were the most discriminating parameters to distinctly identify MAG and DAG derived from different animal fats. This demonstrated that the EA-IRMS and the PCA of fatty acid data have considerable potential for discriminating MAG and DAG derived from lard from other animal fats for Halal authentication purposes. (Author)

  17. Health and aging: development of the Irish Longitudinal Study on Ageing health assessment.

    Science.gov (United States)

    Cronin, Hilary; O'Regan, Clare; Finucane, Ciaran; Kearney, Patricia; Kenny, Rose Anne

    2013-05-01

    To assist researchers planning studies similar to The Irish Longitudinal Study on Ageing (TILDA), concerning the development of the health assessment component, to promote use of the archived data set, to inform researchers of the methods employed, and to complement the accompanying article on normative values. Prospective, longitudinal study of older adults. Republic of Ireland. Eight thousand five hundred four community-dwelling adults who participated in wave 1 of the TILDA study. The main areas of focus for the TILDA health assessments are neurocardiovascular instability, locomotion, and vision. The article describes the scientific rationale for the choice of assessments and seeks to determine the potential advantages of incorporating novel biomeasures and technologies in population-based studies to advance understanding of aging-related disorders. The detailed description of the physical measures will facilitate cross-national comparative research and put into context the normative values outlined in the subsequent article. © 2013, Copyright the Authors Journal compilation © 2013, The American Geriatrics Society.

  18. Effect of smoking on EA and NOS expression as well as NO and ET-1 content in gingival tissue of patients with chronic periodontitis

    Directory of Open Access Journals (Sweden)

    Ying Feng

    2017-02-01

    Full Text Available Objective: To study the effect of smoking on EA and NOS expression as well as NO and ET-1 content in gingival tissue of patients with chronic periodontitis. Methods: Patients diagnosed with periodontitis in our hospital between May 2013 and March 2016 were selected to screen 72 cases of smokers and 80 cases of non-smokers who were enrolled in smoking group and non-smoking group respectively, periodontal tissue was collected to detect the expression of EA, NOS and NLRP3 inflammasome, and gingival crevicular fluid was collected to detect the content of ET-1, NO, inflammatory factors and MMPs. Results: EA expression and ET-1 content in gingival tissue of smoking group were significantly higher than those of nonsmoking group while NOS expression and NO content in gingival tissue were significantly lower than those of non-smoking group; NLRP3, ASC, Caspase-1, IL-1β and IL-18 expression in gingival tissue of smoking group were significantly higher than those of nonsmoking group, and IL-1β, IL-18, TNF-α, IFN-γ, MMP1, MMP8 and MMP13 content in gingival crevicular fluid were significantly higher than those of non-smoking group; NLRP3, ASC, Caspase-1, IL-1β and IL-18 expression as well as IL-1β, IL-18, TNF-α, IFN-γ, MMP1, MMP8 and MMP13 content were positively correlated with EA and ET-1, and negatively correlated with NOS and NO. Conclusion: Smoking can cause increased EA and ET-1 as well as decreased NOS and NO in gingival tissue of patients with chronic periodontitis, thus adjusting the expression of NLRP3 inflammasome and MMPs to periodontal tissue inflammation and structure damage.

  19. MMAS vs. Population-based EA on a family of dynamic fitness functions

    DEFF Research Database (Denmark)

    Lissovoi, Andrei; Witt, Carsten

    2014-01-01

    We study the behavior of a population-based EA and the Max-Min Ant System (MMAS) on a family of deterministically-changing fitness functions, where, in order to find the global optimum, the algorithms have to find specific local optima within each of a series of phases. In particular, we prove...... a Maze function extended over a finite alphabet of μ symbols, whereas population size μ-1 is not sufficient. Furthermore, we show that MMAS does not require additional modifications to track the optimum of the finite-alphabet Maze functions, and, using a novel drift statement to simplify the analysis...

  20. MMAS Versus Population-Based EA on a Family of Dynamic Fitness Functions

    DEFF Research Database (Denmark)

    Lissovoi, Andrei; Witt, Carsten

    2015-01-01

    We study the behavior of a population-based EA and the Max–Min Ant System (MMAS) on a family of deterministically-changing fitness functions, where, in order to find the global optimum, the algorithms have to find specific local optima within each of a series of phases. In particular, we prove...... function extended over a finite alphabet of μ symbols, whereas population size μ−1 is not sufficient. Furthermore, we show that MMAS does not require additional modifications to track the optimum of the finite-alphabet Maze functions, and, using a novel drift statement to simplify the analysis, reduce...

  1. A Longitudinal Investigation of Reading Development from Kindergarten to Grade Eight in a Spanish-Speaking Bilingual Population

    Science.gov (United States)

    Grimm, Ryan P.; Solari, Emily J.; Gerber, Michael M.

    2018-01-01

    This longitudinal study used latent growth curve modeling to investigate English literacy development in a sample of Spanish-speaking language minority students from third through eighth grade. This study also compared the sample's literacy development to the entire population of California students using state standardized test data. Second, this…

  2. Longitudinal adaptation in language development: a study of typically-developing children and children with ASD

    DEFF Research Database (Denmark)

    Weed, Ethan; Fusaroli, Riccardo; Fein, Deborah

    Background: Children with Autism Spectrum Disorder (ASD) often display distinctive language development trajectories (Tek et al., 2013). Because language-learning is a social endeavor, these trajectories could be partially grounded in the dynamics that characterize the children's social and lingu......Background: Children with Autism Spectrum Disorder (ASD) often display distinctive language development trajectories (Tek et al., 2013). Because language-learning is a social endeavor, these trajectories could be partially grounded in the dynamics that characterize the children's social......’s previous behavior. In this study, we tested this model of mutual influence in a longitudinal corpus (6 visits over 2 years), consisting of 30 minutes of controlled playful activities between parents and 66 children (33 ASD and 33 matched typically developing (TD), Goodwin et al. 2012). Methods: We first.......Results:Developmental trajectories: Our models described the developmental trajectories (0.3 ASD (β: from -1.14 to -0.86), with an interaction between the two (children with ASD showed shallower trajectories, β: -2.43 to -1...

  3. Development of a longitudinal integrated clerkship at an academic medical center

    Directory of Open Access Journals (Sweden)

    Ann Poncelet

    2011-04-01

    Full Text Available In 2005, medical educators at the University of California, San Francisco (UCSF, began developing the Parnassus Integrated Student Clinical Experiences (PISCES program, a year-long longitudinal integrated clerkship at its academic medical center. The principles guiding this new clerkship were continuity with faculty preceptors, patients, and peers; a developmentally progressive curriculum with an emphasis on interdisciplinary teaching; and exposure to undiagnosed illness in acute and chronic care settings. Innovative elements included quarterly student evaluation sessions with all preceptors together, peer-to-peer evaluation, and oversight advising with an assigned faculty member. PISCES launched with eight medical students for the 2007/2008 academic year and expanded to 15 students for 2008/2009. Compared to UCSF's traditional core clerkships, evaluations from PISCES indicated significantly higher student satisfaction with faculty teaching, formal didactics, direct observation of clinical skills, and feedback. Student performance on discipline-specific examinations and United States Medical Licensing Examination step 2 CK was equivalent to and on standardized patient examinations was slightly superior to that of traditional peers. Participants’ career interests ranged from primary care to surgical subspecialties. These results demonstrate that a longitudinal integrated clerkship can be implemented successfully at a tertiary care academic medical center.

  4. The development of a methodology to assess population doses from multiple sources and exposure pathways of radioactivity

    International Nuclear Information System (INIS)

    Hancox, J.; Stansby, S.; Thorne, M.

    2002-01-01

    The Environment Agency (EA) has new duties in accordance with the Basic Safety Standards Directive under which it is required to ensure that doses to individuals received from exposure to anthropogenic sources of radioactivity are within defined limits. In order to assess compliance with these requirements, the EA needs to assess the doses to members of the most highly exposed population groups ('critical' groups) from all relevant potential sources of anthropogenic radioactivity and all relevant potential exposure pathways to such radioactivity. The EA has identified a need to develop a methodology for the retrospective assessment of effective doses from multiple sources of radioactive materials and exposure pathways associated with those sources. Under contract to the EA, AEA Technology has undertaken the development of a suitable methodology as part of EA R and D Project P3-070. The methodology developed under this research project has been designed to support the EA in meeting its obligations under the Euratom Basic Safety Standards Directive and is consistent with UK and international approaches to radiation dosimetry and radiological protection. The development and trial application of the methodology is described in this report

  5. Developing longitudinal qualitative designs: lessons learned and recommendations for health services research.

    Science.gov (United States)

    Calman, Lynn; Brunton, Lisa; Molassiotis, Alex

    2013-02-06

    Longitudinal qualitative methods are becoming increasingly used in the health service research, but the method and challenges particular to health care settings are not well described in the literature.We reflect on the strategies used in a longitudinal qualitative study to explore the experience of symptoms in cancer patients and their carers, following participants from diagnosis for twelve months; we highlight ethical, practical, theoretical and methodological issues that need to be considered and addressed from the outset of a longitudinal qualitative study. Key considerations in undertaking longitudinal qualitative projects in health research, include the use of theory, utilizing multiple methods of analysis and giving consideration to the practical and ethical issues at an early stage. These can include issues of time and timing; data collection processes; changing the topic guide over time; recruitment considerations; retention of staff; issues around confidentiality; effects of project on staff and patients, and analyzing data within and across time. As longitudinal qualitative methods are becoming increasingly used in health services research, the methodological and practical challenges particular to health care settings need more robust approaches and conceptual improvement. We provide recommendations for the use of such designs. We have a particular focus on cancer patients, so this paper will have particular relevance for researchers interested in chronic and life limiting conditions.

  6. Differentiation of partial acylglycerols derived from different animal fats by EA-IRMS and GCMS techniques

    Directory of Open Access Journals (Sweden)

    Nina Naquiah, A. N.

    2016-06-01

    Full Text Available A study was carried out to compare partial acylglycerols of lard with those of chicken fat, beef fat and mutton fat using Gas Chromatography Mass Spectrometry (GC-MS and Elemental Analysis–Isotope Ratio Mass Spectrometry (EA-IRMS. Mono- (MAG and di-(DAG acylglycerols of animal fats were prepared according to a chemical glycerolysis method and isolated using column chromatography. The fatty acid composition and δ13C carbon isotope ratio of MAG and DAG derived from individual animal fat were determined separately to establish their identity characteristics. The results showed that the δ13C values of MAG and DAG of lard were significantly different from those of MAG and DAG derived from chicken fat, beef fat and mutton fat. According to the loading plots based on a principle component analysis (PCA, fatty acids namely stearic, oleic and linoleic were the most discriminating parameters to distinctly identify MAG and DAG derived from different animal fats. This demonstrated that the EA-IRMS and the PCA of fatty acid data have considerable potential for discriminating MAG and DAG derived from lard from other animal fats for Halal authentication purposes.Se realizó un estudio para comparar acilgliceroles parciales de la manteca de cerdo con las de grasa de pollo, grasa de vacuno y grasa de cordero utilizando cromatografía de gases-espectrometría de masas (GC-MS y análisis elemental de Isótopos-Espectrometría de Masas (EA-IRMS. Los mono- (MAG y di- (DAG acilgliceroles de grasas animales se prepararon mediante un método de glicerolisis química y se aislaron mediante cromatografía en columna. La composición de ácidos grasos y la relación isotópica de carbono δ13C de los MAG y DAG de las grasas de animales se determinan por separado para establecer sus características de identidad. Los resultados mostraron que los valores de δ13C de MAG y DAG de la manteca de cerdo fue significativamente diferente de los de MAG y DAG derivados de grasa

  7. Study on Soap-free P(MMA-EA-AA/MAA) Latex Particles With Narrow Size Distribution

    Institute of Scientific and Technical Information of China (English)

    K. Kang; C. Y. Kan; Y. Du; D. S. Liu

    2005-01-01

    @@ 1Introduction In the past decades, more and more studies have been focused on the synthesis of monodisperse particles with different diameter by special polymerization technique. In 1980' s, Ugelstad, et al[1] invented two-step swelling method to prepare monodisperse microsphere with large size more than 1 μm. In the following decade, Okubo and his coworkers[2] synthesized monodisperse crosslinked polymer particles above 3 μm using one-step dynamic swelling method. New method has been developed to produce particles more than 50 μm in diameter with a standard deviation of less than 2%[3]. Up to now, most of the monodisperse particles were usually prepared by polymerization of St in the presence of surfactants. In this presentation, sub-micro sized P (MMA-EA-AA/MAA) particles with narrow size distribution were prepared by seeded emulsion polymerization in the absence of any surfactant materials.

  8. Preventing Intellectual and Interactional Sequelae of Fetal Malnutrition: A Longitudinal Transactional, and Synergistic Approach to Development.

    Science.gov (United States)

    Zeskind, Philip Sanford; Ramey, Craig T.

    1981-01-01

    Presents longitudinal data regarding detrimental effects through 36 months of age on intellectual, behavioral, and social-interactional development in a nonsupportive caregiving environment, and the continuing amelioration of those effects in a supportive caregiving environment. Suggests that mothers of fetally malnourished infants may have had…

  9. Behavioral Inhibition as a Risk Factor for the Development of Childhood Anxiety Disorders: A Longitudinal Study

    NARCIS (Netherlands)

    P.E.H.M. Muris (Peter); A.M.L. van Brakel (Anna); A. Arntz (Arnoud); E. Schouten (Erik)

    2011-01-01

    textabstractThis longitudinal study examined the additive and interactive effects of behavioral inhibition and a wide range of other vulnerability factors in the development of anxiety problems in youths. A sample of 261 children, aged 5 to 8 years, 124 behaviorally inhibited and 137 control

  10. 47 CFR 90.699 - Transition of the upper 200 channels in the 800 MHz band to EA licensing.

    Science.gov (United States)

    2010-10-01

    ... are defined as the actual costs associated with providing a replacement system, such as equipment and... activities necessary for implementing the replacement facilities, including engineering and cost analysis of... equipment and analog replacement parts can be difficult to find. An EA licensee's obligation to pay...

  11. Diet, growth, and obesity development throughout childhood in the Avon Longitudinal Study of Parents and Children

    Science.gov (United States)

    Jones, Louise R.

    2015-01-01

    Publications from the Avon Longitudinal Study of Parents and Children covering diet, growth, and obesity development during childhood are reviewed. Diet was assessed by food frequency questionnaires and food records. Growth data were collected by routine measurements, and in standardized clinics, body fatness was assessed by bioelectrical impedance and DXA (dual-energy X-ray absorptiometry) scans. Diets changed dramatically during the preschool period with an increase in the intake of free (added) sugars (12.3% rising to 16.4% of energy) that remained similar until adolescence. This was due to increased intake of energy-dense, nutrient-poor foods. Two periods of rapid growth were identified; infancy and mid-childhood (ages 7–11 y) and both were associated with obesity development. Diets with high energy density were associated with increasing fat mass from mid-childhood until adolescence. Genetic and dietary factors showed independent associations with increasing adiposity. At all ages studied, there were dietary inequalities related to maternal educational attainment that may influence inequalities found in obesity development. The Avon Longitudinal Study of Parents and Children has provided valuable insights into how disparities in diet and growth may affect the development of ill health in adulthood. PMID:26395342

  12. Early Parenting and the Development of Externalizing Behavior Problems: Longitudinal Mediation through Children’s Executive Function

    Science.gov (United States)

    Sulik, Michael J.; Blair, Clancy; Mills-Koonce, Roger; Berry, Daniel; Greenberg, Mark

    2015-01-01

    Path analysis was used to investigate the longitudinal associations among parenting and children’s executive function and externalizing behavior problems from 36 to 90 months of age in the Family Life Project (N = 1,115), a study of child development in the context of rural poverty. While controlling for stability in the constructs, semi-structured observations of parenting prospectively predicted performance on a battery of executive function tasks and primary caregivers’ reports of externalizing behavior. Furthermore, the association between early parenting and later externalizing behavior was longitudinally mediated by executive function, providing support for a process model in which sensitive parenting promotes children’s self-regulation, which in turn reduces children’s externalizing behavior. PMID:26082032

  13. Prevalence of E/A wave fusion and A wave truncation in DDD pacemaker patients with complete AV block under nominal AV intervals.

    Directory of Open Access Journals (Sweden)

    Wolfram C Poller

    Full Text Available Optimization of the AV-interval (AVI in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB under the pre-programmed AVI. We manually optimized sub-optimal AVI.We analyzed 160 pacemaker patients with complete AVB, both in sinus rhythm (AV-sense; n = 129 and under atrial pacing (AV-pace; n = 31. Using Doppler analyses of the transmitral inflow we classified the nominal AVI as: a normal, b too long (E/A wave fusion or c too short (A wave truncation. In patients with a sub-optimal AVI, we performed manual optimization according to the recommendations of the American Society of Echocardiography.All AVB patients with atrial pacing exhibited a normal transmitral inflow under the nominal AV-pace intervals (100%. In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval (CI: 12.6-26.2%. A wave truncations were not observed in any patient. All patients with a complete E/A wave fusion achieved a normal transmitral inflow after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms.Given the rate of 19.4% (CI 12.6-26.2% of patients with a too long nominal AV-sense interval, automatic algorithms may prove useful in improving cardiac hemodynamics, especially in the subgroup of atrially triggered pacemaker patients with AV node diseases.

  14. Deeply inelastic collisions as a source of intermediate mass fragments at E/A = 27 MeV

    International Nuclear Information System (INIS)

    Borderie, B.; Montoya, M.; Rivet, M.F.; Jouan, D.; Cabot, C.; Fuchs, H.; Gardes, D.; Gauvin, H.; Jacquet, D.; Monnet, F.

    1988-01-01

    Intermediate-mass fragments detected in coincidence with heavy residues were measured in 40 Ar induced reactions on Ag at E/A = 27 MeV. From the observed characteristics, it is inferred that intermediate-mass fragments associated with the so-called intermediate-velocity source come mainly from deeply inelastic collisions occurring after or at the same time as preequilibrium particle emission. (orig.)

  15. Language development in deaf children’s interactions with deaf and hearing adults. A Dutch longitudinal study

    NARCIS (Netherlands)

    Klatter-Folmer, H.A.K.; Hout, R.W.N.M. van; Kolen, E.; Verhoeven, L.T.W.

    2006-01-01

    The language development of two deaf girls and four deaf boys in Sign Language of the Netherlands (SLN) and spoken Dutch was investigated longitudinally. At the start, the mean age of the children was 3;5. All data were collected in video-recorded semistructured conversations between individual

  16. Tracking the effects of dyslexia in reading and spelling development: A longitudinal study of Greek readers.

    Science.gov (United States)

    Diamanti, Vassiliki; Goulandris, Nata; Stuart, Morag; Campbell, Ruth; Protopapas, Athanassios

    2018-05-01

    In this study, we followed Greek children with and without dyslexia for 18 months, assessing them twice on a battery of phonological, reading, and spelling tasks, aiming to document the relative progress achieved and to uncover any specific effects of dyslexia in the development of reading and spelling beyond the longitudinal associations among variables that are observed in typical readers. A wide-ranging match was achieved between the dyslexic group and the younger reading-matched comparison group, enabling longitudinal comparisons on essentially identical initial performance profiles. Group differences were found in the development of tasks relying on phonological processing skill, such as phoneme deletion in pseudowords, pseudoword reading accuracy and time, as well as in graphemic spelling accuracy. The results confirm findings from cross-sectional studies of reading difficulty in the relatively transparent Greek orthography and are consistent with a phonological processing deficit underlying and reciprocally interacting with underdevelopment of reading and spelling skills in the impaired population. Copyright © 2018 John Wiley & Sons, Ltd.

  17. Differentiation of lard, chicken fat, beef fat and mutton fat by GCMS and EA-IRMS techniques.

    Science.gov (United States)

    Ahmad Nizar, Nina Naquiah; Nazrim Marikkar, Jalaldeen Mohamed; Hashim, Dzulkifly Mat

    2013-01-01

    A study was conducted to differentiate lard, chicken fat, beef fat and mutton fat using Gas Chromatography Mass Spectrometry (GC-MS) and Elemental Analyzer-Isotope Ratio Mass Spectrometry (EA-IRMS). The comparison of overall fatty acid data showed that lard and chicken fat share common characteristics by having palmitic, oleic and linoleic acid as major fatty acids while beef and mutton fats shared common characteristics by possessing palmitic, stearic and oleic acid as major fatty acids. The direct comparisons among the fatty acid data, therefore, may not be suitable for discrimination of different animal fats. When the fatty acid distributional data was subjected to Principle Component Analysis (PCA), it was demonstrated that stearic, oleic and linoleic acids as the most discriminating parameters in the clustering of animal fats into four subclasses. The bulk carbon analysis of animal fats using EA-IRMS showed that determination of the carbon isotope ratios (δ¹³C) would be a good indicator for discriminating lard, chicken fat, beef fat and mutton fat. This would lead to a faster and more efficient method to ascertain the source of origin of fats used in food products.

  18. Developing critical thinking disposition and emotional intelligence of nursing students: a longitudinal research.

    Science.gov (United States)

    Kaya, Hülya; Şenyuva, Emine; Bodur, Gönül

    2017-01-01

    Emotional Intelligence is considered as an important characteristic of nurses that can affect the quality of their work including clinical decision-making, critical thinking, evidence and knowledge use in practice. The study is aimed to determine nursing students' critical thinking disposition and emotional intelligence in an academic year. A longitudinal design. The focus population of this longitudinal study consists of 197 freshman students studying at a faculty of nursing. Asymmetrical cluster sampling method was used to determine sample group and all the students registered in the first year were included in scope of the study. Information Form, California Critical Thinking Disposition Scale and Emotional Intelligence Assessment Scale were used for data collection. SPSS version 11.5 was used for data analysis. Nursing students have a low level of critical thinking disposition and intermediate level of emotional intelligence both at the beginning and end of academic year. There was no statistically significant difference in both skills at the beginning and end of year. There was a statistically significant difference between students' critical thinking disposition and emotional intelligence at the beginning of academic year. There was a positive correlation at a medium level between students' critical thinking disposition and emotional intelligence at the beginning and end of academic year. In light of these results, it is that suggested the study should be prolonged as longitudinal because development of both skills require a long time. The current study holds importance that it sheds light on other relevant studies and nursing education programs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Characterising the Development of the Understanding of Human Body Systems in High-School Biology Students--A Longitudinal Study

    Science.gov (United States)

    Snapir, Zohar; Eberbach, Catherine; Ben-Zvi-Assaraf, Orit; Hmelo-Silver, Cindy; Tripto, Jaklin

    2017-01-01

    Science education today has become increasingly focused on research into complex natural, social and technological systems. In this study, we examined the development of high-school biology students' systems understanding of the human body, in a three-year longitudinal study. The development of the students' system understanding was evaluated…

  20. Language Development in Context: A Longitudinal Study of Typically-Developing Children and Children with ASD

    DEFF Research Database (Denmark)

    Fusaroli, Riccardo; Weed, Ethan; Fein, Deborah

    Background: Children with Autism Spectrum Disorder (ASD) often display distinctive language development trajectories (Tek et al., 2013). Because language-learning is a social endeavor, these trajectories could be partially grounded in the dynamics that characterize the children's social and lingu......Background: Children with Autism Spectrum Disorder (ASD) often display distinctive language development trajectories (Tek et al., 2013). Because language-learning is a social endeavor, these trajectories could be partially grounded in the dynamics that characterize the children's social...... and linguistic interactions (Waurlamont et al., 2014). Objectives: We investigate language development trajectories and interpersonal linguistic adaptation over time in a longitudinal corpus of parent-child interactions. Methods: Participants included 66 children, 33 with ASD (MA=33 months at visit 1) and 33 TD...... (linear β: -160, -39; quadratic: 22.92, 5.32), group (β: 332, 100.16), severity (β: -27, -8) and Mullen (β: -6, -1.6). Time significantly interacts with Mullen scores (linear β: 7.4, 1.92; quadratic β: -0.84, -0.2). Children with ASD showed shallower trajectories; higher Mullen scores were associated...

  1. Environmental assessment for sustainable development: process, actors and practice

    International Nuclear Information System (INIS)

    Andre, P.; Delisle, C.E.; Reveret, J.-P.

    2003-01-01

    Multiple environmental problems afflict our contemporary world and have been the subject of discussions during many international meetings. All declarations resulting from these meetings insist on including environmental problems and on environmental assessment (EA) as an important tool to achieve this. This book aims to reach three objectives. First, it introduces EA to people from different disciplines, and therefore it opens up the perspective of new disciplinary horizons. Second, the authors discuss EA as a socio-political process rather than emphasizing methodologies. Third, this book draws mainly on the experience in Francophone countries which is still poorly disseminated. This book focusses on process and actors. Thus, the subject matter is divided into five major parts: the history and major issues of EA from a sustainable development perspective (Chapters 1 to 3); the actors, i.e. the Project Proponent and consulting firms, the public, the decision maker and international actors (Chapters 4 to 7); methods and tools including public participation (Chapters 8 and 9); processes in practice through step by step processes in practice and case studies (Chapters 10 and 11); and, finally, recent and upcoming developments in EA, including elements of strategic environmental assessment (Chapters 12 and 13). An index facilitates searching for information. The reader is also invited to consult the book's website

  2. REDES TECNOLÓGICAS APLICADAS EM EaD

    Directory of Open Access Journals (Sweden)

    Suélly Lima dos Santos

    2011-08-01

    Full Text Available Com o advento da internet e o aparecimento das novas tecnologias educacionais, conjunto de informações e comunicações (telefone, internet, rádio, vídeo, computador e televisão, ultrapassaram as fronteiras das quatro paredes da sala de aula, surgindo ambientes virtuais direcionadas à ampliação da participação dos serviços públicos relacionados ao ensino. À educação e à formação técnica e profissional permitiu-se o aumento da interatividade através da tecnologia, promovendo maneiras de acesso ao aluno utilizando computadores e/ou dispositivos móveis que viabiliza a Educação à Distância (EaD. Devido o grande crescimento do ensino à distância, as instituições já utilizam redes de dados para ampliar o acesso de aprendizagem. Com este espantoso aumento das redes, e da acelerada transmissão de informações aprender como elas funcionam é muito importante, além do mais usando a própria tecnologia para este fim. Como conclusão deste trabalho as mudanças relâmpadas da grande disponibilidade de dados no ambiente virtual é de enorme valia para o processo ensino-aprendizado.

  3. Parameterized Linear Longitudinal Airship Model

    Science.gov (United States)

    Kulczycki, Eric; Elfes, Alberto; Bayard, David; Quadrelli, Marco; Johnson, Joseph

    2010-01-01

    A parameterized linear mathematical model of the longitudinal dynamics of an airship is undergoing development. This model is intended to be used in designing control systems for future airships that would operate in the atmospheres of Earth and remote planets. Heretofore, the development of linearized models of the longitudinal dynamics of airships has been costly in that it has been necessary to perform extensive flight testing and to use system-identification techniques to construct models that fit the flight-test data. The present model is a generic one that can be relatively easily specialized to approximate the dynamics of specific airships at specific operating points, without need for further system identification, and with significantly less flight testing. The approach taken in the present development is to merge the linearized dynamical equations of an airship with techniques for estimation of aircraft stability derivatives, and to thereby make it possible to construct a linearized dynamical model of the longitudinal dynamics of a specific airship from geometric and aerodynamic data pertaining to that airship. (It is also planned to develop a model of the lateral dynamics by use of the same methods.) All of the aerodynamic data needed to construct the model of a specific airship can be obtained from wind-tunnel testing and computational fluid dynamics

  4. Cohort profile: the Motorik-Modul Longitudinal Study: physical fitness and physical activity as determinants of health development in German children and adolescents.

    Science.gov (United States)

    Wagner, Matthias O; Bös, Klaus; Jekauc, Darko; Karger, Claudia; Mewes, Nadine; Oberger, Jennifer; Reimers, Anne K; Schlenker, Lars; Worth, Annette; Woll, Alexander

    2014-10-01

    The Motorik-Modul (MoMo) Longitudinal Study aims to contribute to long-term improvement in the health of German children and adolescents by focusing on: (i) the development of physical fitness and physical activity (including period effects); (ii) the individual and physical/social environmental determinants of the development of physical fitness and physical activity; and (iii) the impact of physical fitness and physical activity on the development of physical and mental health. The MoMo Longitudinal Study began with a nationwide representative sample of 4529 children and adolescents who ranged in age from 4-17 years at the study baseline (2003-2006). The first survey wave of the MoMo Longitudinal Study was conducted between 2009 and 2012, with two subsequent survey waves to be conducted between 2014 and 2016 and 2018 and 2020, respectively. The MoMo Longitudinal Study includes a physical fitness test profile, a physical activity questionnaire, and subjective and objective measures of health from the German Health Interview and Examination Survey (KiGGS). Data access is provided on request (alexander.woll@kit.edu). For further information, including a complete list of publications please visit www.motorik-modul.de. Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2013; all rights reserved.

  5. Northeast Empire Limited Partnership No. 2 Alternative Energy, Inc. and Maine Public Service Company (Docket No. EA-95): Environmental Assessment

    International Nuclear Information System (INIS)

    1992-05-01

    This environmental assessment (EA) has been prepared in connection with the application (the Application) by Alternative Energy, Inc. (AEI), Northeast Empire Limited Partnership number-sign 2 (the Partnership) and Maine Public Service Company (MPS and, collectively with AEI and the Partnership, the Applicants), filed on January 6, 1992, for authorization to transmit electric energy to a foreign country. The electric energy to be exported would be produced by a 39-megawatt (MW), wood-fired powerplant (the Project) to be developed by AEI and to be built by the Partnership in Ashland, Maine, which is located in MPS' service territory. In the Application, the Applicants requested authorization for MPS to transmit electricity generated by the Project from Maine through New Brunswick, Canada, on route back to the US for domestic use by Central Maine Power Company (MP). The need to cross the US -Canadian border arises due to the geography of the area and to facilitate access to an existing transmission line. None of the power will be used in Canada. This EA addresses the environmental impacts associated with the export of electric energy and the connected actions which are expected to result from the authorization of those exports. The electricity would be exported over cross-border transmission facilities maintained between MPS and New Brunswick Power Corporation (NB Power). No new cross-border facilities, and no modification of any existing cross-border facilities, are required in connection with the proposed action

  6. Longitudinal Brain Development of Numerical Skills in Typically Developing Children and Children with Developmental Dyscalculia

    Directory of Open Access Journals (Sweden)

    Ursina McCaskey

    2018-01-01

    Full Text Available Developmental dyscalculia (DD is a learning disability affecting the acquisition of numerical-arithmetical skills. Studies report persistent deficits in number processing and aberrant functional activation of the fronto-parietal numerical network in DD. However, the neural development of numerical abilities has been scarcely investigated. The present paper provides a first attempt to investigate behavioral and neural trajectories of numerical abilities longitudinally in typically developing (TD and DD children. During a study period of 4 years, 28 children (8–11 years were evaluated twice by means of neuropsychological tests and a numerical order fMRI paradigm. Over time, TD children improved in numerical abilities and showed a consistent and well-developed fronto-parietal network. In contrast, DD children revealed persistent deficits in number processing and arithmetic. Brain imaging results of the DD group showed an age-related activation increase in parietal regions (intraparietal sulcus, pointing to a delayed development of number processing areas. Besides, an activation increase in frontal areas was observed over time, indicating the use of compensatory mechanisms. In conclusion, results suggest a continuation in neural development of number representation in DD, whereas the neural network for simple ordinal number estimation seems to be stable or show only subtle changes in TD children over time.

  7. Longitudinal Brain Development of Numerical Skills in Typically Developing Children and Children with Developmental Dyscalculia.

    Science.gov (United States)

    McCaskey, Ursina; von Aster, Michael; Maurer, Urs; Martin, Ernst; O'Gorman Tuura, Ruth; Kucian, Karin

    2017-01-01

    Developmental dyscalculia (DD) is a learning disability affecting the acquisition of numerical-arithmetical skills. Studies report persistent deficits in number processing and aberrant functional activation of the fronto-parietal numerical network in DD. However, the neural development of numerical abilities has been scarcely investigated. The present paper provides a first attempt to investigate behavioral and neural trajectories of numerical abilities longitudinally in typically developing (TD) and DD children. During a study period of 4 years, 28 children (8-11 years) were evaluated twice by means of neuropsychological tests and a numerical order fMRI paradigm. Over time, TD children improved in numerical abilities and showed a consistent and well-developed fronto-parietal network. In contrast, DD children revealed persistent deficits in number processing and arithmetic. Brain imaging results of the DD group showed an age-related activation increase in parietal regions (intraparietal sulcus), pointing to a delayed development of number processing areas. Besides, an activation increase in frontal areas was observed over time, indicating the use of compensatory mechanisms. In conclusion, results suggest a continuation in neural development of number representation in DD, whereas the neural network for simple ordinal number estimation seems to be stable or show only subtle changes in TD children over time.

  8. Development of white matter microstructure in relation to verbal and visuospatial working memory—A longitudinal study

    Science.gov (United States)

    Fjell, Anders M.; Tamnes, Christian K.; Grydeland, Håkon; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sampaio-Baptista, Cassandra; Andersson, Jesper; Johansen-Berg, Heidi; Walhovd, Kristine B.

    2018-01-01

    Working memory capacity is pivotal for a broad specter of cognitive tasks and develops throughout childhood. This must in part rely on development of neural connections and white matter microstructure maturation, but there is scarce knowledge of specific relations between this and different aspects of working memory. Diffusion tensor imaging (DTI) enables us to study development of brain white matter microstructure. In a longitudinal DTI study of 148 healthy children between 4 and 11 years scanned twice with an on average 1.6 years interval, we characterized change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD) in 10 major white matter tracts hypothesized to be of importance for working memory. The results showed relationships between change in several tracts and change in visuospatial working memory. Specifically, improvement in visuospatial working memory capacity was significantly associated with decreased MD, RD and AD in inferior longitudinal fasciculus (ILF), inferior fronto-occipital fasciculus (IFOF) and uncinate fasciculus (UF) in the right hemisphere, as well as forceps major (FMaj). No significant relationships were found between change in DTI metrics and change in verbal working memory capacity. These findings yield new knowledge about brain development and corresponding working memory improvements in childhood. PMID:29689058

  9. Diet, growth, and obesity development throughout childhood in the Avon Longitudinal Study of Parents and Children.

    Science.gov (United States)

    Emmett, Pauline M; Jones, Louise R

    2015-10-01

    Publications from the Avon Longitudinal Study of Parents and Children covering diet, growth, and obesity development during childhood are reviewed. Diet was assessed by food frequency questionnaires and food records. Growth data were collected by routine measurements, and in standardized clinics, body fatness was assessed by bioelectrical impedance and DXA (dual-energy X-ray absorptiometry) scans. Diets changed dramatically during the preschool period with an increase in the intake of free (added) sugars (12.3% rising to 16.4% of energy) that remained similar until adolescence. This was due to increased intake of energy-dense, nutrient-poor foods. Two periods of rapid growth were identified; infancy and mid-childhood (ages 7-11 y) and both were associated with obesity development. Diets with high energy density were associated with increasing fat mass from mid-childhood until adolescence. Genetic and dietary factors showed independent associations with increasing adiposity. At all ages studied, there were dietary inequalities related to maternal educational attainment that may influence inequalities found in obesity development. The Avon Longitudinal Study of Parents and Children has provided valuable insights into how disparities in diet and growth may affect the development of ill health in adulthood. © The Author(s) 2015. Published by Oxford University Press on behalf of the International Life Sciences Institute.

  10. Development of white matter microstructure in relation to verbal and visuospatial working memory-A longitudinal study.

    Science.gov (United States)

    Krogsrud, Stine K; Fjell, Anders M; Tamnes, Christian K; Grydeland, Håkon; Due-Tønnessen, Paulina; Bjørnerud, Atle; Sampaio-Baptista, Cassandra; Andersson, Jesper; Johansen-Berg, Heidi; Walhovd, Kristine B

    2018-01-01

    Working memory capacity is pivotal for a broad specter of cognitive tasks and develops throughout childhood. This must in part rely on development of neural connections and white matter microstructure maturation, but there is scarce knowledge of specific relations between this and different aspects of working memory. Diffusion tensor imaging (DTI) enables us to study development of brain white matter microstructure. In a longitudinal DTI study of 148 healthy children between 4 and 11 years scanned twice with an on average 1.6 years interval, we characterized change in fractional anisotropy (FA), mean (MD), radial (RD) and axial diffusivity (AD) in 10 major white matter tracts hypothesized to be of importance for working memory. The results showed relationships between change in several tracts and change in visuospatial working memory. Specifically, improvement in visuospatial working memory capacity was significantly associated with decreased MD, RD and AD in inferior longitudinal fasciculus (ILF), inferior fronto-occipital fasciculus (IFOF) and uncinate fasciculus (UF) in the right hemisphere, as well as forceps major (FMaj). No significant relationships were found between change in DTI metrics and change in verbal working memory capacity. These findings yield new knowledge about brain development and corresponding working memory improvements in childhood.

  11. WH-EA: An Evolutionary Algorithm for Wiener-Hammerstein System Identification

    Directory of Open Access Journals (Sweden)

    J. Zambrano

    2018-01-01

    Full Text Available Current methods to identify Wiener-Hammerstein systems using Best Linear Approximation (BLA involve at least two steps. First, BLA is divided into obtaining front and back linear dynamics of the Wiener-Hammerstein model. Second, a refitting procedure of all parameters is carried out to reduce modelling errors. In this paper, a novel approach to identify Wiener-Hammerstein systems in a single step is proposed. This approach is based on a customized evolutionary algorithm (WH-EA able to look for the best BLA split, capturing at the same time the process static nonlinearity with high precision. Furthermore, to correct possible errors in BLA estimation, the locations of poles and zeros are subtly modified within an adequate search space to allow a fine-tuning of the model. The performance of the proposed approach is analysed by using a demonstration example and a nonlinear system identification benchmark.

  12. A longitudinal study of lexical development in children learning Vietnamese and English.

    Science.gov (United States)

    Pham, Giang; Kohnert, Kathryn

    2014-01-01

    This longitudinal study modeled lexical development among children who spoke Vietnamese as a first language (L1) and English as a second language (L2). Participants (n = 33, initial mean age of 7.3 years) completed a total of eight tasks (four in each language) that measured vocabulary knowledge and lexical processing at four yearly time points. Multivariate hierarchical linear modeling was used to calculate L1 and L2 trajectories within the same model for each task. Main findings included (a) positive growth in each language, (b) greater gains in English resulting in shifts toward L2 dominance, and (c) different patterns for receptive and expressive domains. Timing of shifts to L2 dominance underscored L1 skills that are resilient and vulnerable to increases in L2 proficiency. © 2013 The Authors. Child Development © 2013 Society for Research in Child Development, Inc.

  13. Development of materialism in adolescence: The longitudinal role of life satisfaction among Chinese youths

    OpenAIRE

    Ku, L.

    2014-01-01

    The present research tests the longitudinal role of life satisfaction on materialism among Chinese adolescents, and provides empirical evidence to support the theorisation that materialism develops as compensation for dissatisfaction with life. Study 1 establishes that the negative relationship between life satisfaction and materialism is present and similar among the younger (N = 516; M = 12.94 years) and the older adolescents (N = 531; M = 16.57 years). A two-wave survey (Study 2) finds no ...

  14. Mass yield distributions for the reactions Ca+Ca, Nb+Nb and Ca+Ca at E/A=800 MeV in the molecular-dynamical model

    International Nuclear Information System (INIS)

    Kiselev, S.M.

    1987-01-01

    Mass yield distributions obtained on the basis of the molecular-dynamical model are presented for the Ca+Ca, Nb+Nb reactions at E/A=400 MeV and Ca+Ca reaction at E/A=800 MeV. For the fragments with masses upto quarter of the mass of initial nucleus the model predicts a power law for mass spectra with almost the same value of the exponent. Such the behaviour is roughly a result of the superposition of the fireball breakup and the disintegration of spectator regions rather than the evidence of a liquid-gas-like phase transition in hot nuclear matter

  15. Multigap resistive plate chambers for EAS study in the EEE Project

    CERN Document Server

    An, S; Badalà, A; Zichichi, A

    2007-01-01

    The EEE (Extreme Energy Events) Project, conceived by its leader Antonino Zichichi, is an experiment to study very high-energetic air showers (EAS) through the detection of the shower's muon component using a network of tracking detectors, installed in Italian high schools. The single tracking telescope is composed of three large area () Multi-gap Resistive Plate Chambers (MRPCs). The data collected by the telescopes will be used for studies of air showers and also for the search of time correlations between sites which are far apart. The first telescope, recently installed in the Liceo B. Touschek in Grottaferrata (Rome), is successfully running, and other telescopes are going to be installed in a short time in other towns, opening up the way for the first search of long-distance coincidences over a total area of .

  16. 3α-breakup-induced dynamical polarization potential of 12C at E/A >= 10 MeV

    International Nuclear Information System (INIS)

    Kubono, S.; Sugitani, M.; Tanaka, M.H.; Morita, K.; Sakuragi, Y.; Kamimura, M.

    1985-06-01

    The important role of the 3α-breakup processes to the optical potential of 12 C at E/A >= 10 MeV has been shown by observing directly the excitation of the 7.65-MeV 0 2 + state which breaks into 3α clusters. The 3α-breakup processes also explain well the previously unknown reduction factor for the exit-channel real potential for the same state. (author)

  17. Development of Nurses' Professional Competence Early in Their Career: A Longitudinal Study.

    Science.gov (United States)

    Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

    2017-01-01

    Research on newly graduated nurses' competence development and associated factors is relatively scarce. Data for this longitudinal, descriptive, correlation study were collected during 2012-2014 from 318 Finnish nurses to explore their competence development during the first 3 years after graduation and to estimate the extent to which given work-related factors predicted change in competence. Data were analyzed using NCSS 10 statistical software. Nurses' initially fairly high level of competence showed an increase in the third year, as measured by the Nurse Competence Scale. Empowerment increased minimally, whereas perceptions of practice environment, ethical climate, and occupational commitment decreased. Willingness to leave the profession and dissatisfaction with current job and nursing profession increased. Empowerment, satisfaction with current job and quality of care, time from graduation, and work experience explained 25.6% of the change in competence. Competence development was modest but increasing. Willingness to leave the profession was concerning. Factors enhancing or preventing competence development need further studying and developing proactive interventions. J Contin Educ Nurs. 2017;48(1):29-39. Copyright 2017, SLACK Incorporated.

  18. Risky business: Correlation and causation in longitudinal studies of skill development.

    Science.gov (United States)

    Bailey, Drew H; Duncan, Greg J; Watts, Tyler; Clements, Doug H; Sarama, Julie

    2018-01-01

    Developmental theories often posit that changes in children's early psychological characteristics will affect much later psychological, social, and economic outcomes. However, tests of these theories frequently yield results that are consistent with plausible alternative theories that posit a much smaller causal role for earlier levels of these psychological characteristics. Our article explores this issue with empirical tests of skill-building theories, which predict that early boosts to simpler skills (e.g., numeracy or literacy) or behaviors (e.g., antisocial behavior or executive functions) support the long-term development of more sophisticated skills or behaviors. Substantial longitudinal associations between academic or socioemotional skills measured early and then later in childhood or adolescence are often taken as support of these skill-building processes. Using the example of skill-building in mathematics, we argue that longitudinal correlations, even if adjusted for an extensive set of baseline covariates, constitute an insufficiently risky test of skill-building theories. We first show that experimental manipulation of early math skills generates much smaller effects on later math achievement than the nonexperimental literature has suggested. We then conduct falsification tests that show puzzlingly high cross-domain associations between early math and later literacy achievement. Finally, we show that a skill-building model positing a combination of unmeasured stable factors and skill-building processes can reproduce the pattern of experimental impacts on children's mathematics achievement. Implications for developmental theories, methods, and practice are discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  19. Motor Development and Physical Activity: A Longitudinal Discordant Twin-Pair Study.

    Science.gov (United States)

    Aaltonen, Sari; Latvala, Antti; Rose, Richard J; Pulkkinen, Lea; Kujala, Urho M; Kaprio, Jaakko; Silventoinen, Karri

    2015-10-01

    Previous longitudinal research suggests that motor proficiency in early life predicts physical activity in adulthood. Familial effects including genetic and environmental factors could explain the association, but no long-term follow-up studies have taken into account potential confounding by genetic and social family background. The present twin study investigated whether childhood motor skill development is associated with leisure-time physical activity levels in adulthood independent of family background. Altogether, 1550 twin pairs from the FinnTwin12 study and 1752 twin pairs from the FinnTwin16 study were included in the analysis. Childhood motor development was assessed by the parents' report of whether one of the co-twins had been ahead of the other in different indicators of motor skill development in childhood. Leisure-time physical activity (MET·h·d) was self-reported by the twins in young adulthood and adulthood. Statistical analyses included conditional and ordinary linear regression models within twin pairs. Using all activity-discordant twin pairs, the within-pair difference in a sum score of motor development in childhood predicted the within-pair difference in the leisure-time physical activity level in young adulthood (P men and women.

  20. An enhanced rate of tidal disruptions in the centrally overdense E+A galaxy NGC 3156

    OpenAIRE

    Stone, Nicholas C.; van Velzen, Sjoert

    2016-01-01

    Time domain optical surveys have discovered roughly a dozen candidate stellar tidal disruption flares in the last five years, and future surveys like the {\\it Large Synoptic Survey Telescope} will likely find hundreds to thousands more. These tidal disruption events (TDEs) present an interesting puzzle: a majority of the current TDE sample is hosted by rare post-starburst galaxies, and tens of percent are hosted in even rarer E+A galaxies, which make up $\\sim 0.1\\%$ of all galaxies in the loc...

  1. Self-Esteem Development across the Life Span: A Longitudinal Study with a Large Sample from Germany

    Science.gov (United States)

    Orth, Ulrich; Maes, Jürgen; Schmitt, Manfred

    2015-01-01

    The authors examined the development of self-esteem across the life span. Data came from a German longitudinal study with 3 assessments across 4 years of a sample of 2,509 individuals ages 14 to 89 years. The self-esteem measure used showed strong measurement invariance across assessments and birth cohorts. Latent growth curve analyses indicated…

  2. Análise da utilização das tecnologias da informação e comunicação na educação a distância (EaD.

    Directory of Open Access Journals (Sweden)

    Carla Simone Pires

    2017-02-01

    Full Text Available A EaD se caracteriza por docentes e discentes fisicamente separados, conectados por TICs. No Brasil a EaD não é recente, entretanto, tem aumentado nos últimos anos devido a políticas públicas e à evolução das TICs, entretanto, a sua aplicação normalmente tem foco na economia de recursos. Apesar das dificuldades encontradas, é tendência mundial e converge para o uso de tecnologias. Neste sentido, TICs podem causar inclusão/exclusão social, dependendo de como sua utilização é planejadas. O mesmo ocorre com processos avaliativos, que mostram fragilidades. Os resultados permitem concluir que a transição para EaD não apresenta mudanças de práticas pedagógicas. Apesar disto, tem importante papel social, uma vez que vem suprir demandas reprimidas no que tange o acesso à educação superior, além de incentivar o desenvolvimento de municípios com Baixos Índice de Desenvolvimento Humano (IDH e Índice de Desenvolvimento da Educação Básica (IDEB. Ainda, mostra a necessidade de redimensionar as práticas de ensino (reinventando usos para TICs na transição entre ensino presencial e EaD, possibilitando que a EaD assuma sua função social na educação brasileira. Neste sentido,  Este trabalho teve como objetivo fazer um estudo analítico do contexto da Educação a Distância (EaD no Brasil, as práticas pedagógicas usadas e o papel das Tecnologias de Informação (TICs neste processo.

  3. Observation of lateral substructures in EAS by measurement of the time distribution of atmospheric Cerenkov light

    International Nuclear Information System (INIS)

    Bosia, G.; Navarra, G.; Saavedra, O.

    1975-01-01

    The lateral structure of EAS is derived from the arrival time distribution of atmospheric Cerenkov light assuming a strict correlation between time structure and lateral particle distribution. Results of the Pic du Midi experiment are presented. Substructures in the time distribution of the Cerenkov light can be related to structures in the lateral density distribution of electrons. The frequency (a few %) of substructures can be explained within conventional models of high energy interactions. (orig.) [de

  4. The longitudinal development of social and executive functions in late adolescence and early adulthood

    Directory of Open Access Journals (Sweden)

    Sophie Jane Taylor

    2015-09-01

    Full Text Available Our earlier work suggests that executive functions and social cognition show protracted development into late adolescence and early adulthood (Taylor, Barker, Heavey and McHale, 2013. However, it remains unknown whether these functions develop linearly or non-linearly corresponding to dynamic changes to white matter density at these age ranges. Executive functions are particularly in demand during the transition to independence and autonomy associated with this age range (Ahmed and Miller, 2011. Previous research examining executive function (Romine and Reynolds, 2005 and social cognition (Dumontheil, Apperly and Blakemore, 2010 in late adolescence has utilised a cross sectional design. The current study employed a longitudinal design with 58 participants aged 17, 18 and 19 years completing social cognition and executive function tasks, Wechsler Abbreviated Scale of Intelligence (Wechsler, 1999, Positive and Negative Affect Schedule (Watson, Clark and Tellegen, 1988 and Hospital Anxiety and Depression Scale (Zigmond and Snaith, 1983 at Time 1 with follow up testing 12 to 16 months later. Inhibition, rule detection, strategy generation and planning executive functions and emotion recognition with dynamic stimuli showed longitudinal development between time points. Self-report empathy and emotion recognition functions using visual static and auditory stimuli were stable by age 17 whereas concept formation declined between time points. The protracted development of some functions may reflect continued brain maturation into late adolescence and early adulthood including synaptic pruning (Sowell, Thompson, Tessner and Toga, 2001 and changes to functional connectivity (Stevens, Kiehl, Pearlson and Calhouln, 2007 and/or environmental change. Clinical implications, such as assessing the effectiveness of rehabilitation following Head Injury, are discussed.

  5. Optimization of on-line hydrogen stable isotope ratio measurements of halogen- and sulfur-bearing organic compounds using elemental analyzer-chromium/high-temperature conversion isotope ratio mass spectrometry (EA-Cr/HTC-IRMS).

    Science.gov (United States)

    Gehre, Matthias; Renpenning, Julian; Geilmann, Heike; Qi, Haiping; Coplen, Tyler B; Kümmel, Steffen; Ivdra, Natalija; Brand, Willi A; Schimmelmann, Arndt

    2017-03-30

    Accurate hydrogen isotopic analysis of halogen- and sulfur-bearing organics has not been possible with traditional high-temperature conversion (HTC) because the formation of hydrogen-bearing reaction products other than molecular hydrogen (H 2 ) is responsible for non-quantitative H 2 yields and possible hydrogen isotopic fractionation. Our previously introduced, new chromium-based EA-Cr/HTC-IRMS (Elemental Analyzer-Chromium/High-Temperature Conversion Isotope Ratio Mass Spectrometry) technique focused primarily on nitrogen-bearing compounds. Several technical and analytical issues concerning halogen- and sulfur-bearing samples, however, remained unresolved and required further refinement of the reactor systems. The EA-Cr/HTC reactor was substantially modified for the conversion of halogen- and sulfur-bearing samples. The performance of the novel conversion setup for solid and liquid samples was monitored and optimized using a simultaneously operating dual-detection system of IRMS and ion trap MS. The method with several variants in the reactor, including the addition of manganese metal chips, was evaluated in three laboratories using EA-Cr/HTC-IRMS (on-line method) and compared with traditional uranium-reduction-based conversion combined with manual dual-inlet IRMS analysis (off-line method) in one laboratory. The modified EA-Cr/HTC reactor setup showed an overall H 2 -recovery of more than 96% for all halogen- and sulfur-bearing organic compounds. All results were successfully normalized via two-point calibration with VSMOW-SLAP reference waters. Precise and accurate hydrogen isotopic analysis was achieved for a variety of organics containing F-, Cl-, Br-, I-, and S-bearing heteroelements. The robust nature of the on-line EA-Cr/HTC technique was demonstrated by a series of 196 consecutive measurements with a single reactor filling. The optimized EA-Cr/HTC reactor design can be implemented in existing analytical equipment using commercially available material and

  6. Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice

    Science.gov (United States)

    Sharpton, Thomas; Lyalina, Svetlana; Luong, Julie; Pham, Joey; Deal, Emily M.; Armour, Courtney; Gaulke, Christopher; Sanjabi, Shomyseh

    2017-01-01

    ABSTRACT The gut microbiome is linked to inflammatory bowel disease (IBD) severity and altered in late-stage disease. However, it is unclear how gut microbial communities change over the course of IBD development, especially in regard to function. To investigate microbiome-mediated disease mechanisms and discover early biomarkers of IBD, we conducted a longitudinal metagenomic investigation in an established mouse model of IBD, where damped transforming growth factor β (TGF-β) signaling in T cells leads to peripheral immune activation, weight loss, and severe colitis. IBD development is associated with abnormal gut microbiome temporal dynamics, including damped acquisition of functional diversity and significant differences in abundance trajectories for KEGG modules such as glycosaminoglycan degradation, cellular chemotaxis, and type III and IV secretion systems. Most differences between sick and control mice emerge when mice begin to lose weight and heightened T cell activation is detected in peripheral blood. However, levels of lipooligosaccharide transporter abundance diverge prior to immune activation, indicating that it could be a predisease indicator or microbiome-mediated disease mechanism. Taxonomic structure of the gut microbiome also significantly changes in association with IBD development, and the abundances of particular taxa, including several species of Bacteroides, correlate with immune activation. These discoveries were enabled by our use of generalized linear mixed-effects models to test for differences in longitudinal profiles between healthy and diseased mice while accounting for the distributions of taxon and gene counts in metagenomic data. These findings demonstrate that longitudinal metagenomics is useful for discovering the potential mechanisms through which the gut microbiome becomes altered in IBD. IMPORTANCE IBD patients harbor distinct microbial communities with functional capabilities different from those seen with healthy people

  7. Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice.

    Science.gov (United States)

    Sharpton, Thomas; Lyalina, Svetlana; Luong, Julie; Pham, Joey; Deal, Emily M; Armour, Courtney; Gaulke, Christopher; Sanjabi, Shomyseh; Pollard, Katherine S

    2017-01-01

    The gut microbiome is linked to inflammatory bowel disease (IBD) severity and altered in late-stage disease. However, it is unclear how gut microbial communities change over the course of IBD development, especially in regard to function. To investigate microbiome-mediated disease mechanisms and discover early biomarkers of IBD, we conducted a longitudinal metagenomic investigation in an established mouse model of IBD, where damped transforming growth factor β (TGF-β) signaling in T cells leads to peripheral immune activation, weight loss, and severe colitis. IBD development is associated with abnormal gut microbiome temporal dynamics, including damped acquisition of functional diversity and significant differences in abundance trajectories for KEGG modules such as glycosaminoglycan degradation, cellular chemotaxis, and type III and IV secretion systems. Most differences between sick and control mice emerge when mice begin to lose weight and heightened T cell activation is detected in peripheral blood. However, levels of lipooligosaccharide transporter abundance diverge prior to immune activation, indicating that it could be a predisease indicator or microbiome-mediated disease mechanism. Taxonomic structure of the gut microbiome also significantly changes in association with IBD development, and the abundances of particular taxa, including several species of Bacteroides , correlate with immune activation. These discoveries were enabled by our use of generalized linear mixed-effects models to test for differences in longitudinal profiles between healthy and diseased mice while accounting for the distributions of taxon and gene counts in metagenomic data. These findings demonstrate that longitudinal metagenomics is useful for discovering the potential mechanisms through which the gut microbiome becomes altered in IBD. IMPORTANCE IBD patients harbor distinct microbial communities with functional capabilities different from those seen with healthy people. But is

  8. Systematics of complex fragment emission from La induced reactions at E/A = 47 MeV

    International Nuclear Information System (INIS)

    Kehoe, W.L.; Mignerey, A.C.; Bradley, S.

    1989-03-01

    Complex fragment (Z > 2) emission was studied in the reverse kinematics reactions of 139 La on 27 Al and /sup nat./Cu at a bombarding energy of E/A = 47 MeV. Experimental results from inclusive and coincidence measurements for two- and three-fold complex fragments events are presented. Measured cross sections and Z 1 -Z 2 correlations show a predominately binary-decay process for the La + Al reaction, while the La + Cu reaction is dominated by multi-body decay. 18 refs., 9 figs., 1 tab

  9. Search for EAS radio-emission at the Tien-Shan shower installation at a height of 3340 m above sea level

    Science.gov (United States)

    Beisenova, A.; Boos, E.; Haungs, A.; Sadykov, T.; Salihov, N.; Shepetov, A.; Tautayev, Y.; Vildanova, L.; Zhukov, V.

    2017-06-01

    The complex EAS installation of the Tien Shan mountain cosmic ray station which is situated at a height of 3340 m above sea level includes the scintillation and Cherenkov detectors of charged shower particles, an ionization calorimeter and a set of neutron detectors for registering the hadronic component of the shower, and a number of underground detectors of the penetrative EAS component. Now it is intended to expand this installation with a promising method for detecting the radio-emission generated by the particles of the developing shower. The facility for radio-emission detection consists of a three crossed dipole antennae, one being set vertically, and another two - mutually perpendicularly in a horizontal plane, all of them being connected to a three-channel radio-frequency amplifier of German production. By the passage of an extensive air shower, which is defined by a scintillation shower detector system, the output signal of antenna amplifier is digitized by a fast multichannel DT5720 ADC of Italian production, and kept within computer memory. The further analysis of the detected signal anticipates its operation according to a special algorithm and a search for the pulse of radio-emission from the shower. A functional test of the radio-installation is made with artificial signals which imitate those of the shower, and with the use of a N1996A type wave analyzer of Agilent Technologies production. We present preliminary results on the registration of extensive air shower emission at the Tien Shan installation which were collected during test measurements held in Summer 2016.

  10. Characteristics of EAS and primary particle mass composition in the energy region of 1017-3.1019 eV by Yakutsk data

    International Nuclear Information System (INIS)

    Knurenko, S.P.; Egorova, V.P.; Ivanov, A.A.; Kolosov, V.A.; Makarov, I.T.; Petrov, Z.E.; Sleptsov, I.Ye.; Struchkov, G.G.

    2006-01-01

    In this work the data of the Yakutsk complex EAS array and their comparison with calculation in the case of primary nuclei of different chemical elements are presented. The calculation by QGSJET model have been used interpreting experimental data

  11. Variable selection and estimation for longitudinal survey data

    KAUST Repository

    Wang, Li

    2014-09-01

    There is wide interest in studying longitudinal surveys where sample subjects are observed successively over time. Longitudinal surveys have been used in many areas today, for example, in the health and social sciences, to explore relationships or to identify significant variables in regression settings. This paper develops a general strategy for the model selection problem in longitudinal sample surveys. A survey weighted penalized estimating equation approach is proposed to select significant variables and estimate the coefficients simultaneously. The proposed estimators are design consistent and perform as well as the oracle procedure when the correct submodel was known. The estimating function bootstrap is applied to obtain the standard errors of the estimated parameters with good accuracy. A fast and efficient variable selection algorithm is developed to identify significant variables for complex longitudinal survey data. Simulated examples are illustrated to show the usefulness of the proposed methodology under various model settings and sampling designs. © 2014 Elsevier Inc.

  12. Longitudinal development of cortical thickness, folding, and fiber density networks in the first 2 years of life.

    Science.gov (United States)

    Nie, Jingxin; Li, Gang; Wang, Li; Shi, Feng; Lin, Weili; Gilmore, John H; Shen, Dinggang

    2014-08-01

    Quantitatively characterizing the development of cortical anatomical networks during the early stage of life plays an important role in revealing the relationship between cortical structural connection and high-level functional development. The development of correlation networks of cortical-thickness, cortical folding, and fiber-density is systematically analyzed in this article to study the relationship between different anatomical properties during the first 2 years of life. Specifically, longitudinal MR images of 73 healthy subjects from birth to 2 year old are used. For each subject at each time point, its measures of cortical thickness, cortical folding, and fiber density are projected to its cortical surface that has been partitioned into 78 cortical regions. Then, the correlation matrices for cortical thickness, cortical folding, and fiber density at each time point can be constructed, respectively, by computing the inter-regional Pearson correlation coefficient (of any pair of ROIs) across all 73 subjects. Finally, the presence/absence pattern (i.e., binary pattern) of the connection network is constructed from each inter-regional correlation matrix, and its statistical and anatomical properties are adopted to analyze the longitudinal development of anatomical networks. The results show that the development of anatomical network could be characterized differently by using different anatomical properties (i.e., using cortical thickness, cortical folding, or fiber density). Copyright © 2013 Wiley Periodicals, Inc.

  13. Effect of medium components and culture conditions in Bacillus subtilis EA-CB0575 spore production.

    Science.gov (United States)

    Posada-Uribe, Luisa F; Romero-Tabarez, Magally; Villegas-Escobar, Valeska

    2015-10-01

    Bacillus subtilis spores have important biotechnological applications; however, achieving both, high spore cell densities and sporulation efficiencies in fermentation, is poorly reported. In this study, medium components and culture conditions were optimized with different statistical methods to increase spore production of the plant growth promoting rhizobacteria B. subtilis EA-CB0575. Key medium components were determined with Plackett-Burman (PB) design, and the optimum concentration levels of two components (glucose, MgSO4·7H2O) were optimized with a full factorial and central composite design, achieving 1.37 × 10(9) CFU/mL of spore cell density and 93.5 % of sporulation efficiency in shake flask. The optimized medium was used to determine the effect of culture conditions on spore production at bioreactor level, finding that maintaining pH control did not affect significantly spore production, while the interaction of agitation and aeration rates had a significant effect on spore cell density. The overall optimization generated a 17.2-fold increase in spore cell density (8.78 × 10(9) CFU/mL) and 1.9-fold increase in sporulation efficiency (94.2 %) compared to that of PB design. These results indicate the potential of B. subtilis EA-CB0575 to produce both, high spore cell densities and sporulation efficiencies, with very low nutrient requirements and short incubation period which can represent savings of process production.

  14. A longitudinal study on gross motor development in children with learning disorders.

    Science.gov (United States)

    Westendorp, Marieke; Hartman, Esther; Houwen, Suzanne; Huijgen, Barbara C H; Smith, Joanne; Visscher, Chris

    2014-02-01

    This longitudinal study examined the development of gross motor skills, and sex-differences therein, in 7- to 11-years-old children with learning disorders (LD) and compared the results with typically developing children to determine the performance level of children with LD. In children with LD (n=56; 39 boys, 17 girls), gross motor skills were assessed with the Test of Gross Motor Development-2 and measured annually during a 3-year period. Motor scores of 253 typically developing children (125 boys, 112 girls) were collected for references values. The multilevel analyses showed that the ball skills of children with LD improved with age (p50). Boys had higher ball skill scores than girls (p=.002) and these differences were constant over time. Typically developing children outperformed the children with LD on the locomotor skills and ball skills at all ages, except the locomotor skills at age 7. Children with LD develop their ball skills later in the primary school-period compared to typically developing peers. However, 11 year-old children with LD had a lag in locomotor skills and ball skills of at least four and three years, respectively, compared to their peers. Copyright © 2013 Elsevier Ltd. All rights reserved.

  15. After the Fall: The Dust and Gas in E+A Post-starburst Galaxies

    Science.gov (United States)

    Smercina, A.; Smith, J. D. T.; Dale, D. A.; French, K. D.; Croxall, K. V.; Zhukovska, S.; Togi, A.; Bell, E. F.; Crocker, A. F.; Draine, B. T.; Jarrett, T. H.; Tremonti, C.; Yang, Yujin; Zabludoff, A. I.

    2018-03-01

    The traditional picture of post-starburst galaxies as dust- and gas-poor merger remnants, rapidly transitioning to quiescence, has been recently challenged. Unexpected detections of a significant interstellar medium (ISM) in many post-starburst galaxies raise important questions. Are they truly quiescent, and if so, what mechanisms inhibit further star formation? What processes dominate their ISM energetics? We present an infrared spectroscopic and photometric survey of 33 E+A post-starbursts selected by the Sloan Digital Sky Survey, aimed at resolving these questions. We find compact, warm dust reservoirs with high PAH abundances and total gas and dust masses significantly higher than expected from stellar recycling alone. Both polycyclic aromatic hydrocarbon (PAH)/total infrared (TIR) and dust-to-burst stellar mass ratios are seen to decrease with post-burst age, indicative of the accumulating effects of dust destruction and an incipient transition to hot, early-type ISM properties. Their infrared spectral properties are unique, with dominant PAH emission, very weak nebular lines, unusually strong H2 rotational emission, and deep [C II] deficits. There is substantial scatter among star formation rate (SFR) indicators, and both PAH and TIR luminosities provide overestimates. Even as potential upper limits, all tracers show that the SFR has typically experienced a decline of more than two orders of magnitude since the starburst and that the SFR is considerably lower than expected given both their stellar masses and molecular gas densities. These results paint a coherent picture of systems in which star formation was, indeed, rapidly truncated, but in which the ISM was not completely expelled, and is instead supported against collapse by latent or continued injection of turbulent or mechanical heating. The resulting aging burst populations provide a “high-soft” radiation field that seemingly dominates the E+A galaxies’ unusual ISM energetics.

  16. Maternal weight predicts children’s psychosocial development via parenting stress and emotional availability

    Directory of Open Access Journals (Sweden)

    Sarah Bergmann

    2016-08-01

    Full Text Available Introduction: Maternal obesity has been shown to be a risk factor for obesity in children and may also affect children’s psychosocial outcomes. It is not yet clear whether there are also psycho-emotional mechanisms explaining the effects of maternal weight on young children’s weight and psychosocial development. We aimed to evaluate whether maternal body mass index (BMI, mother-child emotional availability (EA and maternal parenting stress are associated with children’s weight and psychosocial development (i.e. internalizing/externalizing symptoms and social competence and whether these predictors interact with each other. Methods: This longitudinal study included 3 assessment points (approx. 11 months apart. The baseline sample consisted of N=194 mothers and their children aged 5 to 47 months (M=28.18, SD=8.44, 99 girls. At t1, we measured maternal weight and height to calculate maternal BMI. We videotaped mother-child interactions, coding them with the Emotional Availability Scales (4th edition. We assessed maternal parenting stress with the Parenting Stress Index (PSI short form. At t1 to t3, we measured height and weight of children and calculated BMI-SDS scores. Children’s externalizing and internalizing problems (t1-t3 and social competence (t3, N=118 were assessed using questionnaires: Child Behavior Checklist (CBCL1, 5-5, Strength and Difficulties Questionnaire (SDQ: prosocial behavior and a checklist for behavioral problems at preschool age (VBV 3-6: social-emotional competence. Results: By applying structural equation modeling (SEM and a latent regression analysis, we found maternal BMI to predict higher BMI-SDS and a poorer psychosocial development (higher externalizing symptoms, lower social competence in children. Higher parenting stress predicted higher levels of externalizing and internalizing symptoms and lower social competence. Better maternal EA was associated with higher social competence. We found parenting stress to

  17. Selective attention relates to the development of executive functions in 2,5- to 3-year-olds : A longitudinal study

    NARCIS (Netherlands)

    Veer, Ilona M.; Luyten, Hans; Mulder, Hanna; van Tuijl, Cathy; Sleegers, Peter J.C.

    2017-01-01

    To study the central role of selective attention in the early development of executive functions (EFs), longitudinal relationships between selective attention, working memory, and simple response inhibition were explored. Selective attention, working memory, and simple response inhibition were

  18. Electron-Muon Identification by Atmospheric Shower and Electron Beam in a New EAS Detector Concept

    Science.gov (United States)

    Iori, M.; Denizli, H.; Yilmaz, A.; Ferrarotto, F.; Russ, J.

    2015-03-01

    We present results demonstrating the time resolution and μ/e separation capabilities of a new concept for an EAS detector capable of measuring cosmic rays arriving with large zenith angles. This kind of detector has been designed to be part of a large area (several square kilometer) surface array designed to measure ultra high energy (10-200 PeV) τ neutrinos using the Earth-skimming technique. A criterion to identify electron-gammas is also shown and the particle identification capability is tested by measurements in coincidence with the KASKADE-GRANDE experiment in Karlsruhe, Germany.

  19. Population Size vs. Mutation Strength for the (1+λ) EA on OneMax

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2015-01-01

    The (1+1) EA with mutation probability c/n, where c>0 is an arbitrary constant, is studied for the classical OneMax function. Its expected optimization time is analyzed exactly (up to lower order terms) as a function of c and λ. It turns out that 1/n is the only optimal mutation probability if λ......=o(ln n ln ln n/ln ln ln n), which is the cut-off point for linear mnspeed-up. However, if λ is above this cut-off point then the standard mutation probability 1/n is no longer the only optimal choice. Instead, the expected number of generations is (up to lower order terms) independent of c...

  20. A longitudinal examination of maternal, family, and area-level experiences of racism on children's socioemotional development: Patterns and possible explanations.

    Science.gov (United States)

    Bécares, Laia; Nazroo, James; Kelly, Yvonne

    2015-10-01

    The association between experienced racial discrimination and poor health is now well documented, particularly among adult populations. However, longitudinal studies of the association between racism and child health are limited, and evidence on how racial discrimination experienced by members of children's immediate environment impact on child development, and the mechanisms by which this occurs, is scarce. We examined the longitudinal association between maternal, family, and area-level experiences of racial discrimination, and children's socioemotional development. We proposed that exposure to racial discrimination would be detrimental to children's socioemotional development via two mother-centred stress pathways: a worsening in maternal mental health, and an increase in harsh parenting practices. Data on ethnic minority mothers and their children were drawn from waves 3 to 5 (2006-2012) of the UK Millennium Cohort Study. Results of longitudinal path analyses show a strong association between maternal and family experiences of racial discrimination in wave 3, and a worsening in mother's mental health in wave 4. Maternal and family experiences of racial discrimination at wave 3 had an indirect effect on children's socioemotional development at wave 5. This occurred mainly via a worsening in mother's mental health, although some events of racial discrimination experienced by the mother and other family members also impacted negatively on children's socioemotional development via an increase in harsh parenting practices. We found a direct effect of maternal and family experiences of racial discrimination on children's socioemotional development. Our findings document the harm of growing up in a racist environment on the socioemotional development of children, and provide some evidence for the role of mother-centred stress mechanisms in linking vicarious exposure to racial discrimination to children's socioemotional development. Copyright © 2015 The Authors

  1. OJKO-project: Longitudinal study on the development of young children with a serious cognitive and motor developmental delay

    NARCIS (Netherlands)

    Colla, Stephy; Van Keer, Ines; Schalen, Gertruud Henrike; van der Putten, Annette; Visser, Linda; Maes, Bea; Vlaskamp, Carla; van der Meulen, Bieuwe

    2015-01-01

    Recently, a longitudinal project on the development of children with a serious cognitive and motor developmental delay has started in Belgium and the Netherlands. The aims of this study are to evaluate the cognitive, motor, communicative and social-emotional abilities of young children with a severe

  2. Longitudinal coupled-bunch instability studies in the PS

    CERN Document Server

    Damerau, H

    2017-01-01

    The main longitudinal limitation for LHC-type beams inthe PS are coupled-bunch instabilities. A dedicated proto-typefeedbacksystemusingaFinemetcavityasalongitudinalkicker has been installed. Extensive tests with beam havebeen performed to explore the intensity reach with this feed-back. The maximum intensity with nominal longitudinalemittance at PS extraction has been measured, as well as theemittance required to keep the beam longitudinally stableat the design intensity for the High-Luminosity LHC (HL-LHC). A higher-harmonic cavity is a complementary op-tion to extend the intensity reach beyond the capabilities ofthe coupled-bunch feedback. Preliminary machine develop-ment (MD) studies operating one20MHzor one40MHzRF system as a higher harmonic at the flat-top indicate thebeneficial effect on longitudinal beam stability

  3. Suppression of Longitudinal Coupled-Bunch Instabilities at the KEK-PF

    International Nuclear Information System (INIS)

    Obina, T.; Tobiyama, M.; Honda, T.; Tadano, M.; Flanagan, J.W.; Mitsuhashi, T.; Cheng, W.X.; Fox, J.D.; Teytelman, D.

    2012-01-01

    A bunch-by-bunch feedback system has been developed to suppress longitudinal coupled-bunch instabilities at the KEK-PF. A longitudinal kicker based on a DAFNE-type overdamped cavity has been designed and installed in the ring, and a general purpose signal processor, called iGp, has been developed by the collaboration of the KEK, SLAC, and INFN-LNF. The entire feedback loop has been closed by the end of June 2007, and the feedback system has successfully suppressed the longitudinal dipole-mode instabilities up to 430 mA.

  4. Effects of ballet training of children in Turkey on foot anthropometric measurements and medial longitudinal arc development.

    Science.gov (United States)

    Ozdinc, Sevgi Anar; Turan, Fatma Nesrin

    2016-07-01

    To investigate the effects of ballet training on foot structure and the formation of the medial longitudinal arc in childhood, and the association of body mass index with structural change secondary to ballet training. This study was conducted at Öykü Ballet and Dance School and Trakya University, Edirne, Turkey, from September 2007 to November 2008, and comprised girl students who were taking ballet classes, and a group of those who were not taking such who acted as the controls. Static footprints of both feet of all participants were taken with an ink paedogram. Parameters evaluated from footprints included foot length, metatarsal width, heel width and medial longitudinal arch. The relationship between the parameters, the ballet starting age, training duration and body mass index was investigated. Of the 67 participants, there were 36(53.7%) in the experimental group and 31(48.3%) in the control group. The difference between age, height, weight and body mass index between the two groups was insignificant (p>0.05). The average ballet starting age was 6.47±1.55 years and duration was 4.36±2.002 years. Positive correlations were found between body mass index and foot length, metatarsal width, heel width, medial longitudinal arch contact width and halluxvalgus angle; between ballet starting age and metatarsal width, heel width; between duration of training and foot length, metatarsal width and hallux valgus angle (p?0.05 each). Evidence supporting the education in children on foot anthropometric measurements and medial longitudinal arc development could not be found.

  5. Serial-order short-term memory predicts vocabulary development: evidence from a longitudinal study.

    Science.gov (United States)

    Leclercq, Anne-Lise; Majerus, Steve

    2010-03-01

    Serial-order short-term memory (STM), as opposed to item STM, has been shown to be very consistently associated with lexical learning abilities in cross-sectional study designs. This study investigated longitudinal predictions between serial-order STM and vocabulary development. Tasks maximizing the temporary retention of either serial-order or item information were administered to kindergarten children aged 4 and 5. At age 4, age 5, and from age 4 to age 5, serial-order STM capacities, but not item STM capacities, were specifically associated with vocabulary development. Moreover, the increase of serial-order STM capacity from age 4 to age 5 predicted the increase of vocabulary knowledge over the same time period. These results support a theoretical position that assumes an important role for serial-order STM capacities in vocabulary acquisition.

  6. Framing the ecosystem concept through a longitudinal study of developments in science and policy.

    Science.gov (United States)

    Aggestam, Filip

    2015-08-01

    This paper examines how scientific literature and policy documents frame the ecosystem concept and how these frames have shaped scientific dialogue and policy making over time. This was achieved by developing a frame typology, as a basis for organizing relevant value expressions, to assess how different frames have altered perspectives of the ecosystem concept. The frame typology and analysis is based on a semi-grounded and longitudinal document analysis of scientific literature and policy documents using the ecosystem concept. Despite changing discourses and public priorities (e.g., cultural constructs of biodiversity) both science and policy documents are characterized by stable value systems that have not changed substantially since the 1930s. These value systems were defined based on ethical principles that delineate 6 core frames: humans first, dual systems, eco-science, eco-holism, animals first, and multicentrism. Specific crises (e.g., climate change) and cross-disciplinary uptake and re-uptake of, for example, the ecosystem services concept, have brought new perspectives to the forefront of public discourse. These developments triggered changes in the core frames that, rather than being value based, are based on how the ecosystem is conceptualized under fixed value systems and over time. Fourteen subframes were developed to reflect these longitudinal changes. There are as such clear framing effects in both scientific literature and in policy. Ecosystem research is for instance often characterized by unstated value judgments even though the scientific community does not make these explicit. In contrast, policy documents are characterized by clear value expressions but are principally management driven and human centered. © 2015 Society for Conservation Biology.

  7. Sequential Progressions in a Theory of Mind Scale: Longitudinal Perspectives

    Science.gov (United States)

    Wellman, Henry M.; Fuxi, Fang; Peterson, Candida C.

    2011-01-01

    Consecutive re-testings of 92 U.S. preschoolers (n = 30), Chinese preschoolers (n = 31), and deaf children (n = 31) examined whether the sequences of development apparent in cross-sectional results with a theory-of-mind scale also appeared in longitudinal assessment. Longitudinal data confirmed that theory-of-mind progressions apparent in cross-sectional scaling data also characterized longitudinal sequences of understanding for individual children. The match between cross-sectional and longitudinal sequences appeared for children who exhibit different progressions across cultures (U.S. vs. China) and for children with substantial delays (deaf children of hearing parents). Moreover, greater scale distances reflected larger longitudinal age differences. PMID:21428982

  8. Development of sedentary behavior across childhood and adolescence: longitudinal analysis of the Gateshead Millennium Study

    OpenAIRE

    Janssen, Xanne; Mann, Kay D.; Basterfield, Laura; Parkinson, Kathryn N.; Pearce, Mark S.; Reilly, Jessica K.; Adamson, Ashley J.; Reilly, John J.

    2016-01-01

    Background In many parts of the world policy and research interventions to modify sedentary behavior of children and adolescents are now being developed. However, the evidence to inform these interventions (e.g. how sedentary behavior changes across childhood and adolescence) is limited. This study aimed to assess longitudinal changes in sedentary behavior, and examine the degree of tracking of sedentary behavior from age 7y to 15y. Methods Participants were part of the Gateshead Millennium S...

  9. Do you see my growth? : Two longitudinal studies on personality development from childhood to young adulthood from multiple perspectives

    NARCIS (Netherlands)

    Luan, Z.; Hutteman, R.; Denissen, J.J.A.; Asendorpf, J.B.; van Aken, M.A.G.

    2017-01-01

    Personality developmental studies typically rely on single reporter data, while multi-informant studies are rare. In two longitudinal studies, the present investigation examined inter-judge differences in the development of the Big Five personality traits from childhood to young adulthood. Study 1

  10. A Longitudinal Study of Adolescent Adjustment Following Family Transitions

    Science.gov (United States)

    Ruschena, Eda; Prior, Margot; Sanson, Ann; Smart, Diana

    2005-01-01

    Background: This study examined the impact of family transitions, that is, parental separation, divorce, remarriage and death, upon the lives of Australian children and adolescents in a longitudinal study of temperament and development. Methods: Using longitudinal and concurrent questionnaire data, outcomes for young people experiencing…

  11. A psychology based approach for longitudinal development in cognitive robotics

    Directory of Open Access Journals (Sweden)

    James eLaw

    2014-01-01

    Full Text Available A major challenge in robotics is the ability to learn, from novel experiences, new behaviour that is useful for achieving new goals and skills. Autonomous systems must be able to learn solely through the environment, thus ruling out a priori task knowledge, tuning, extensive training, or other forms of pre-programming. Learning must also be cumulative and incremental, as complex skills are built on top of primitive skills. Additionally, it must be driven by intrinsic motivation because formative experience is gained through autonomous activity, even in the absence of extrinsic goals or tasks. This paper presents an approach to these issues through robotic implementations inspired by the learning behaviour of human infants. We describe an approach to developmental learning and present results from a demonstration of longitudinal development on an iCub humanoid robot. The results cover the rapid emergence of staged behaviour, the role of constraints in development, the effect of bootstrapping between stages, and the use of a schema memory of experiential fragments in learning new skills. The context is a longitudinalexperiment in which the robot advanced from uncontrolled motor babbling to skilled hand/eyeintegrated reaching and basic manipulation of objects. This approach offers promise for furtherfast and effective sensory-motor learning techniques for robotic learning.

  12. Preliminary Studies of the Demonstration Plant of the Energy Amplifier (EA) by LAESA

    International Nuclear Information System (INIS)

    Abanades, A.; Nunez-Lagos, R.; Perez-Navarro, A.; Rubio, J.A.

    1998-01-01

    On July 1997, an international company named LAESA has finished its foundational period, with the headquarters in Zaragoza. The main initial goal of the company is, based on the conceptual design of an Energy Amplifier from C. Rubbia and collaborators, to take the necessary steps for developing the engineering design and the construction of a demonstration unit of EA (approx 100 MWt in its first phase and 250 MWt in the second one). The company will be mainly charged of the technical aspects required by the construction of the prototype and its funding comes both from private and public capital, as well as the selling of services. The prototype intends to use a final accelerator current of approx 12 mA and a beam energy close to 400 MeV. The construction period is expected to be 5 to t years and the initial emphasis of the installation is to demonstrate its capability for a massive incineration of long lived radioactive waste, with the corresponding energy generation. The necessary development to prepare de engineering design is being the subject of a R and D programme in Spain. Other countries with or without companies inside LAESA are also carrying on other Rand D programmes. The expected planning foresees an integrated R and D programme, a first version of the engineering design and the initial contacts both with the Spanish Nuclear Regulatory Commission, as well as the Spanish Environmental authorities. During the Conference, the status of the engineering design will be shown. (Author) 3 refs

  13. Intimacy development in late adolescence: Longitudinal associations with perceived parental autonomy support and adolescents' self-worth.

    Science.gov (United States)

    Van Petegem, Stijn; Brenning, Katrijn; Baudat, Sophie; Beyers, Wim; Zimmer-Gembeck, Melanie J

    2018-03-21

    The present longitudinal study tested for the role of perceived parental autonomy-support and late adolescents' self-worth in their intimacy development. A sample of 497 Belgian late adolescents (M age  = 17.9, 43.5% girls) participated in this two-wave study. Results indicated that perceived autonomy-supportive parenting did not relate significantly to change in adolescents' experienced intimacy (in terms of closeness and mutuality), but was associated with a decrease in unmitigated agency (an excessive focus on the self) and unmitigated communion (an excessive focus on the other) across time. Adolescents' self-worth predicted an increase in experienced intimacy and a decrease in unmitigated agency and communion, and the initial level of experienced intimacy predicted an increase in self-worth. Finally, results suggested that adolescents' self-worth may mediate some of the longitudinal relations between perceived parental autonomy-support and adolescents' intimate functioning. No evidence was found for moderation by romantic involvement, gender or age. Copyright © 2018. Published by Elsevier Ltd.

  14. Longitudinal development of muons in large air showers studies from the arrival time distributions measured at 900m above sea level

    Science.gov (United States)

    Kakimoto, F.; Tsuchimoto, I.; Enoki, T.; Suga, K.; Nishi, K.

    1985-01-01

    The arrival time distributions of muons with energies above 1.0GeV and 0.5GeV have been measured in the Akeno air-shower array to study the longitudinal development of muons in air showers with primary energies in the range 10 to the 17th power to 10 to the 18th power ev. The average rise times of muons with energies above 1.0GeV at large core distances are consistent with those expected from very high multiplicity models and, on the contrary, with those expected from the low multiplicity models at small core distances. This implies that the longitudinal development at atmospheric depth smaller than 500 cm square is very fast and that at larger atmospheric depths is rather slow.

  15. Bayesian Nonparametric Longitudinal Data Analysis.

    Science.gov (United States)

    Quintana, Fernando A; Johnson, Wesley O; Waetjen, Elaine; Gold, Ellen

    2016-01-01

    Practical Bayesian nonparametric methods have been developed across a wide variety of contexts. Here, we develop a novel statistical model that generalizes standard mixed models for longitudinal data that include flexible mean functions as well as combined compound symmetry (CS) and autoregressive (AR) covariance structures. AR structure is often specified through the use of a Gaussian process (GP) with covariance functions that allow longitudinal data to be more correlated if they are observed closer in time than if they are observed farther apart. We allow for AR structure by considering a broader class of models that incorporates a Dirichlet Process Mixture (DPM) over the covariance parameters of the GP. We are able to take advantage of modern Bayesian statistical methods in making full predictive inferences and about characteristics of longitudinal profiles and their differences across covariate combinations. We also take advantage of the generality of our model, which provides for estimation of a variety of covariance structures. We observe that models that fail to incorporate CS or AR structure can result in very poor estimation of a covariance or correlation matrix. In our illustration using hormone data observed on women through the menopausal transition, biology dictates the use of a generalized family of sigmoid functions as a model for time trends across subpopulation categories.

  16. Sustainable development in Indian mines through environmental audit

    International Nuclear Information System (INIS)

    Badrinath, S.D.; Raman, N.S.

    1994-01-01

    Mining in India has been diversifying into progressively more capital intensive and energy intensive areas which are degrading the quality of environment. Considering the future environmental and energy scenarios, the impact the mining has on environmental quality and occupational health/safety of mine workers, Environmental Audit (EA) deserves to be adopted as a pre-requisite for sustainable development and environmental management of Indian mines. EA is a structured and comprehensive mechanism for ensuring that the mining activities do not adversely affect the environmental quality and the economy of mining sector improves as a consequence of improved process and energy effectiveness as also the occupational health and safety. This paper emphasizes that the successful EA program investigates all possibilities of energy saving, material saving and water budgeting through conservation of resources to protection of environment. The paper presents the various options for environmental management in mining industry, including reactive control measures on one hand and anticipative/preventive strategies on the other. The paper also reviews the EA skills and audit protocols along with a discussion of key audit techniques. 12 refs., 5 figs

  17. Getting Personal with Teacher Burnout: A Longitudinal Study on the Development of Burnout Using a Person-Based Approach

    Science.gov (United States)

    Hultell, Daniel; Melin, Bo; Gustavsson, J. Petter

    2013-01-01

    Studies have suggested that teachers' burnout levels are stable over time. This might be because longitudinal studies on burnout have mainly used a variable-based approach. The purpose of this study was to determine if a person-based approach could provide a more multifaceted perspective to the development of teacher burnout. 816 beginning…

  18. ELECTRON–MUON IDENTIFICATION BY ATMOSPHERIC SHOWER AND ELECTRON BEAM IN A NEW EAS DETECTOR CONCEPT

    Energy Technology Data Exchange (ETDEWEB)

    Iori, M. [“Sapienza” Univeristy of Rome, Piazzale A. Moro 5, Rome I-00185 (Italy); Denizli, H.; Yilmaz, A. [Abant Izzet Baysal University, Bolu 14280 (Turkey); Ferrarotto, F. [Istituto Nazionale di Fisica Nucleare (INFN)—Sezione di Roma, Rome I-00185 (Italy); Russ, J., E-mail: Maurizio.Iori@roma1.infn.it [Carnegie-Mellon University, Pittsburgh, PA 15213 (United States)

    2015-03-10

    We present results demonstrating the time resolution and μ/e separation capabilities of a new concept  for an EAS detector capable of measuring cosmic rays arriving with large zenith angles. This kind of detector has been designed to be part of a large area (several square kilometer) surface array designed to measure ultra high energy (10–200 PeV) τ neutrinos using the Earth-skimming technique. A criterion to identify electron-gammas is also shown and the particle identification capability is tested by measurements in coincidence with the KASKADE-GRANDE experiment in Karlsruhe, Germany.

  19. Longitudinal beam compression for heavy-ion inertial fusion

    International Nuclear Information System (INIS)

    Ho, D.D.M.; Brandon, S.T.

    1991-01-01

    A scheme is described for compressing a heavy-ion beam longitudinally in such a way that the compressed pulse has uniform line-charge density and longitudinal momentum. Attaining these conditions will be important in the final focusing of a beam on a small fuel capsule in an inertial confinement fusion reactor. The longitudinal dynamics can be approximately described by a one-dimensional (1-D) fluid model for charged particles. Recognizing the similarity between the 1-D charged particle equations of motion and the 1-D equations for ideal-gas flow permits us to calculate the evolution of the line-charge density and velocity profile using self-similar solutions and the method of characteristics, developed for unsteady supersonic gas dynamics, for different regions along the beam. Simple physical arguments show that although the longitudinal and transverse temperatures vary along the beam following the adiabatic laws, no substantial longitudinal and transverse emittance growth is to be expected. Particle-in-cell simulations confirm all the physical arguments. The compressed beam has negligible longitudinal momentum spread and can therefore avoid chromatic aberrations in final focus. (author) 24 refs., 5 figs., 1 tab

  20. Explaining the increasing heritability of cognitive ability across development: a meta-analysis of longitudinal twin and adoption studies.

    Science.gov (United States)

    Briley, Daniel A; Tucker-Drob, Elliot M

    2013-09-01

    Genes account for increasing proportions of variation in cognitive ability across development, but the mechanisms underlying these increases remain unclear. We conducted a meta-analysis of longitudinal behavioral genetic studies spanning infancy to adolescence. We identified relevant data from 16 articles with 11 unique samples containing a total of 11,500 twin and sibling pairs who were all reared together and measured at least twice between the ages of 6 months and 18 years. Longitudinal behavioral genetic models were used to estimate the extent to which early genetic influences on cognition were amplified over time and the extent to which innovative genetic influences arose with time. Results indicated that in early childhood, innovative genetic influences predominate but that innovation quickly diminishes, and amplified influences account for increasing heritability following age 8 years.

  1. Early Parenting and the Development of Externalizing Behavior Problems: Longitudinal Mediation through Children’s Executive Function

    OpenAIRE

    Sulik, Michael J.; Blair, Clancy; Mills-Koonce, Roger; Berry, Daniel; Greenberg, Mark

    2015-01-01

    Path analysis was used to investigate the longitudinal associations among parenting and children’s executive function and externalizing behavior problems from 36 to 90 months of age in the Family Life Project (N = 1,115), a study of child development in the context of rural poverty. While controlling for stability in the constructs, semi-structured observations of parenting prospectively predicted performance on a battery of executive function tasks and primary caregivers’ reports of external...

  2. Rate Constant and Temperature Dependence for the Reaction of Hydroxyl Radicals with 2-Flouropropane (FC-281ea) and Comparison with an Estimated Rate Constant

    Science.gov (United States)

    DeMore, W.; Wilson, E., Jr.

    1998-01-01

    Relative rate experiments were used to measure the rate constant and temperature dependence of the reaction of OH radicals with 2-fluoropropane (HFC-281ea), using ethane, propane, ethyl chloride as reference standards.

  3. English as a Foreign Language Spelling Development: A Longitudinal Study

    Science.gov (United States)

    Kahn-Horwitz, Janina; Sparks, Richard L.; Goldstein, Zahava

    2012-01-01

    English as a foreign language (EFL) spelling was examined longitudinally three times (4th, 9th, 12th grades) during 9 years of EFL study among Hebrew first language (L1) students. The study examined the impact of L1 literacy variables including phonemic awareness, word attack, and spelling on EFL spelling and the relationship between EFL literacy…

  4. Weaving leadership longitudinally: a qualitative study on faculty development

    OpenAIRE

    Joyce, Pauline

    2015-01-01

    Purpose The purpose of this study was to explore if faculty who undertake teacher preparation, which has a leadership intervention across each module, are better prepared to take on educational leadership roles. Methods A cross sectional qualitative approach was used as part of a longitudinal evaluation of a program. The aim was to explore the perceptions of a purposive sample across three cohorts of students. Data was collected via semi-structured interviews and were analyzed by thema...

  5. Stable Carbon Isotope Ratio (δ13C Measurement of Graphite Using EA-IRMS System

    Directory of Open Access Journals (Sweden)

    Andrius Garbaras

    2015-06-01

    Full Text Available δ13C values in non-irradiated natural graphite were measured. The measurements were carried out using an elemental analyzer combined with stable isotope ratio mass spectrometer (EA-IRMS. The samples were prepared with ground and non-ground graphite, the part of which was mixed with Mg (ClO42. The best combustion of graphite in the oxidation furnace of the elemental analyzer was achieved when the amount of pulverized graphite ranged from 200 to 490 µg and the mass ratio C:Mg(ClO42 was approximately 1:10. The method for the graphite burning avoiding the isotope fractionation is proposed.DOI: http://dx.doi.org/10.5755/j01.ms.21.2.6873

  6. New aspects in nucleon-nucleus collisions and EAS properties around 10(6) GeV

    International Nuclear Information System (INIS)

    Capdevielle, J.N.; Gawin, J.

    1985-01-01

    At energies higher than 2 x 10 to the 5 GeV, very little information exists on detailed properties of nucleon-nucleon collision; the rare elements are coming from jets and as nondirect improvements from gamma-ray families. The results exhibit some conflicting features, or at least, very large fluctuations like copious production of gamma rays in opposition to Centauro-like events, which suggest that phase transition to quark-gluon plasma occurs in nucleus-nucleus collisions and even in nucleon-nucleus collision. The multicluster phenomenological model (MPM) is extrapolated for EAS simulation up to 5 x 10 to the 6 GeV to put in evidence some significant deviation between experimental data and prediction

  7. Team development and team performance. Responsibilities, responsiveness and results : A longitudinal study of teamwork at Volvo Trucks Umeå

    NARCIS (Netherlands)

    Kuipers, B.

    2005-01-01

    A three-year longitudinal study of more than 150 self-managing work teams was carried out at Volvo Trucks Umea, Sweden. Data obtained by this study were used to test a model about the performance effects of team development, answering the following research questions: (1) how can the team

  8. Surface-Layer (S-Layer) Proteins Sap and EA1 Govern the Binding of the S-Layer-Associated Protein BslO at the Cell Septa of Bacillus anthracis

    Science.gov (United States)

    Kern, Valerie J.; Kern, Justin W.; Theriot, Julie A.; Schneewind, Olaf

    2012-01-01

    The Gram-positive pathogen Bacillus anthracis contains 24 genes whose products harbor the structurally conserved surface-layer (S-layer) homology (SLH) domain. Proteins endowed with the SLH domain associate with the secondary cell wall polysaccharide (SCWP) following secretion. Two such proteins, Sap and EA1, have the unique ability to self-assemble into a paracrystalline layer on the surface of bacilli and form S layers. Other SLH domain proteins can also be found within the S layer and have been designated Bacillus S-layer-associated protein (BSLs). While both S-layer proteins and BSLs bind the same SCWP, their deposition on the cell surface is not random. For example, BslO is targeted to septal peptidoglycan zones, where it catalyzes the separation of daughter cells. Here we show that an insertional lesion in the sap structural gene results in elongated chains of bacilli, as observed with a bslO mutant. The chain length of the sap mutant can be reduced by the addition of purified BslO in the culture medium. This complementation in trans can be explained by an increased deposition of BslO onto the surface of sap mutant bacilli that extends beyond chain septa. Using fluorescence microscopy, we observed that the Sap S layer does not overlap the EA1 S layer and slowly yields to the EA1 S layer in a growth-phase-dependent manner. Although present all over bacilli, Sap S-layer patches are not observed at septa. Thus, we propose that the dynamic Sap/EA1 S-layer coverage of the envelope restricts the deposition of BslO to the SCWP at septal rings. PMID:22609927

  9. A Longitudinal Study of Lexical Development in Children Learning Vietnamese and English

    Science.gov (United States)

    Pham, Giang; Kohnert, Kathryn

    2013-01-01

    This longitudinal study modeled lexical development among children who spoke Vietnamese as a first language (L1) and English as a second language (L2). Participants (n=33, initial mean age of 7.3 years) completed a total of eight tasks (four in each language) that measured vocabulary knowledge and lexical processing at four yearly time points. Multivariate hierarchical linear modeling was used to calculate L1 and L2 trajectories within the same model for each task. Main findings included (a) positive growth in each language, (b) greater gains in English resulting in shifts toward L2 dominance, and (c) different patterns for receptive and expressive domains. Timing of shifts to L2 dominance underscored L1 skills that are resilient and vulnerable to increases in L2 proficiency. PMID:23869741

  10. Longitudinal observations of globally distributed design teams: The impacts on Product Development

    DEFF Research Database (Denmark)

    Taylor, Thomas Paul; Ahmed-Kristensen, Saeema

    2015-01-01

    Factors impacting the success of Product Development (PD) projects are intensified when teams are distributed globally, making it a challenging task for project management to deal with effects on time, cost and quality. It is important for project management to understand when challenges......, such as communication difficulties, a lack of common vision between team members or issues related to documentation, may occur during PD projects, enabling them to take the necessary preventative action (Edmondson and Nembhard, 2009). When investigating factors impacting the success of PD, the majority of research...... studies of globally distributed design teams in PD projects. This paper aims to contribute to the further understanding of the factors impacting the success of PD projects when teams are distributed globally. With the results from a longitudinal observational study over 8 months, the factors impacting...

  11. Longitudinal muscle dysfunction in achalasia esophagus and its relevance.

    Science.gov (United States)

    Mittal, Ravinder K; Hong, Su Jin; Bhargava, Valmik

    2013-04-01

    Muscularis propria of the esophagus is organized into circular and longitudinal muscle layers. Goal of this review is to summarize the role of longitudinal muscle in physiology and pathophysiology of esophageal sensory and motor function. Simultaneous manometry and ultrasound imaging that measure circular and longitudinal muscle contraction respectively reveal that during peristalsis 2 layers of the esophagus contract in perfect synchrony. On the other hand, during transient relaxation of the lower esophageal sphincter (LES), longitudinal muscle contracts independently of circular muscle. Recent studies provide novel insights, i.e., longitudinal muscle contraction of the esophagus induces LES relaxation and possibly descending relaxation of the esophagus. In achalasia esophagus and other motility disorders there is discoordination between the 2 muscle layers. Longitudinal muscle contraction patterns are different in the recently described three types of achalasia identified by high-resolution manometry. Robust contraction of the longitudinal muscle in type II achalasia causes pan-esophageal pressurization and is the mechanism of whatever little esophageal emptying that take place in the absence of peristalsis and impaired LES relaxation. It may be that preserved longitudinal muscle contraction is also the reason for superior outcome to medical/surgical therapy in type II achalasia esophagus. Prolonged contractions of longitudinal muscles of the esophagus is a possible mechanism of heartburn and "angina like" pain seen in esophageal motility disorders and possibly achalasia esophagus. Novel techniques to record longitudinal muscle contraction are on the horizon. Neuro-pharmacologic control of circular and longitudinal muscles is different, which provides an important opportunity for the development of novel pharmacological therapies to treat sensory and motor disorders of the esophagus.

  12. Longitudinal heritability of childhood aggression

    NARCIS (Netherlands)

    Porsch, R.M.P.; Middeldorp, C.M.; Cherny, S.S.; Krapohl, E.; van Beijsterveldt, C.E.M.; Loukola, A.; Korhonen, T.; Pulkkinen, L.; Corley, R.P.; Rhee, S.; Kaprio, J.; Rose, R.; Hewitt, J.K.; Sham, P.; Plomin, R.; Boomsma, D.I.; Bartels, M.

    2016-01-01

    The genetic and environmental contributions to the variation and longitudinal stability in childhood aggressive behavior were assessed in two large twin cohorts, the Netherlands Twin Register (NTR), and the Twins Early Development Study (TEDS; United Kingdom). In NTR, maternal ratings on aggression

  13. A Study of E+A Galaxies Through SDSS-MaNGA Integral Field Spectroscopy

    Science.gov (United States)

    Wally, Muhammad; Weaver, Olivia A.; Anderson, Miguel Ricardo; Liu, Allen; Falcone, Julia; Wallack, Nicole Lisa; James, Olivia; Liu, Charles

    2017-01-01

    We outline the selection process and analysis of sixteen E+A galaxies observed by the Mapping Nearby Galaxies at the Apache Point Observatory (MaNGA) survey as a part of the fourth generation of the Sloan Digital Sky Survey (SDSS-IV). We present their Integral field spectroscopy and analyze their spatial distribution of stellar ages, metallicities and other stellar population properties. We can potentially study the variation in these properties as a function of redshift. This work was supported by the Alfred P. Sloan Foundation via the SDSS-IV Faculty and Student Team (FAST) initiative, ARC Agreement #SSP483 to the CUNY College of Staten Island. This work was also supported by grants to The American Museum of Natural History, and the CUNY College of Staten Island through The National Science Foundation.

  14. Sailuotong Prevents Hydrogen Peroxide (H2O2-Induced Injury in EA.hy926 Cells

    Directory of Open Access Journals (Sweden)

    Sai Wang Seto

    2017-01-01

    Full Text Available Sailuotong (SLT is a standardised three-herb formulation consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus designed for the management of vascular dementia. While the latest clinical trials have demonstrated beneficial effects of SLT in vascular dementia, the underlying cellular mechanisms have not been fully explored. The aim of this study was to assess the ability and mechanisms of SLT to act against hydrogen peroxide (H2O2-induced oxidative damage in cultured human vascular endothelial cells (EAhy926. SLT (1–50 µg/mL significantly suppressed the H2O2-induced cell death and abolished the H2O2-induced reactive oxygen species (ROS generation in a concentration-dependent manner. Similarly, H2O2 (0.5 mM; 24 h caused a ~2-fold increase in lactate dehydrogenase (LDH release from the EA.hy926 cells which were significantly suppressed by SLT (1–50 µg/mL in a concentration-dependent manner. Incubation of SLT (50 µg/mL increased superoxide dismutase (SOD activity and suppressed the H2O2-enhanced Bax/Bcl-2 ratio and cleaved caspase-3 expression. In conclusion, our results suggest that SLT protects EA.hy916 cells against H2O2-mediated injury via direct reduction of intracellular ROS generation and an increase in SOD activity. These protective effects are closely associated with the inhibition of the apoptotic death cascade via the suppression of caspase-3 activation and reduction of Bax/Bcl-2 ratio, thereby indicating a potential mechanism of action for the clinical effects observed.

  15. Longitudinal stability of the folding pattern of the anterior cingulate cortex during development

    Directory of Open Access Journals (Sweden)

    A. Cachia

    2016-06-01

    Full Text Available Prenatal processes are likely critical for the differences in cognitive ability and disease risk that unfold in postnatal life. Prenatally established cortical folding patterns are increasingly studied as an adult proxy for earlier development events – under the as yet untested assumption that an individual's folding pattern is developmentally fixed. Here, we provide the first empirical test of this stability assumption using 263 longitudinally-acquired structural MRI brain scans from 75 typically developing individuals spanning ages 7 to 32 years. We focus on the anterior cingulate cortex (ACC – an intensely studied cortical region that presents two qualitatively distinct and reliably classifiable sulcal patterns with links to postnatal behavior. We show – without exception–that individual ACC sulcal patterns are fixed from childhood to adulthood, at the same time that quantitative anatomical ACC metrics are undergoing profound developmental change. Our findings buttress use of folding typology as a postnatally-stable marker for linking variations in early brain development to later neurocognitive outcomes in ex utero life.

  16. Teaching Technology Longitudinally to Virtual Children

    Science.gov (United States)

    Matthews, Lynley

    2010-01-01

    Children of Generation Y are entering our schooling system. These children have always known instant communication and the internet. They possess basic skills in using technology, but they still need to develop a deeper understanding of technology. Teaching longitudinally will increase the learner's confidence and develop a deeper understanding.…

  17. Carta Acuerdo Dirección de EaD - y Dirección SeDiCI

    OpenAIRE

    Universidad Nacional de La Plata; Dirección de Educación a Distancia, Innovación en el aula y TIC (EAD)

    2012-01-01

    Establecer un marco de colaboración técnica entre la Dirección de Educación a Distancia Innovación en el aula y TIC (EaD) y el Servicio de Difusión de la Creación Intelectual (SeDiCI) de la UNLP, de modo de potenciar el desarrollo de actividades conjuntas en temas de interés común, aprovechando al máximo los recursos humanos y de infraestructura con los que cuentan. En este contexto crear un Repositorio Abierto de Objetos de Aprendizaje (OA) que permita integrar la producción de la UNLP y ...

  18. Final Environmental Assessment (EA) for Modification of Airspace Units R-3008A/B/C from Visual Flight Rules (VFR) to VFR-Instrument Flight Rules (IFR) at Moody Air Force Base, Georgia

    Science.gov (United States)

    2015-09-30

    RULES ( IFR ) AT MOODY AIR FORCE BASE, GEORGIA September 2015 Finding of No Significant Impact Modification of Airspace Units R-3008A/B/C from...Interactions with Federally- Recognized Tribes. These tribal governments were also consulted regarding impacts to Final EA for VFR- IFR in R-3008A/B/C at Moody...analysis would focus on impacts to these Final EA for VFR- IFR in R-3008A/B/C at Moody AFB September 2015 2-5 resources from proposed activities

  19. Use of Diffusion Spectrum imaging in preliminary longitudinal evaluation of Amyotrophic Lateral Sclerosis: development of an imaging biomarker

    Directory of Open Access Journals (Sweden)

    Kumar eAbhinav

    2014-04-01

    Full Text Available Previous diffusion tensor imaging (DTI studies have shown white matter pathology in ALS, predominantly in the motor pathways. Further these studies have shown that DTI can be used longitudinally to track pathology over time, making white matter pathology a candidate as an outcome measure in future trials. DTI has demonstrated application in group studies, however its derived indices, for example fractional anisotropy, are susceptible to partial volume effects, making its role questionable in examining individual progression. We hypothesize that changes in the white matter are present in ALS beyond the motor tracts, and that the affected pathways and associated pattern of disease progression can be tracked longitudinally using automated diffusion connectometry analysis. Connectometry analysis is based on diffusion spectrum imaging (DSI and overcomes the limitations of a conventional tractography approach and DTI. The identified affected white matter tracts can then be assessed in a targeted fashion using High definition fiber tractography (a novel white matter MR imaging technique. Changes in quantitative and qualitative markers over time could then be correlated with clinical progression.We illustrate these principles towards developing an imaging biomarker for demonstrating individual progression, by presenting results for five ALS patients, including with longitudinal data in two. Preliminary analysis demonstrated a number of changes bilaterally and asymmetrically in motoric and extramotoric white matter pathways. Further the limbic system was also affected possibly explaining the cognitive symptoms in ALS. In the two longitudinal subjects, the white matter changes were less extensive at baseline, although there was evidence of disease progression in a frontal pattern with a relatively spared postcentral gyrus, consistent with the known pathology in ALS.

  20. Bidirectional Associations between Bedtime Parenting and Infant Sleep: Parenting Quality, Parenting Practices, and their Interaction

    Science.gov (United States)

    Philbrook, Lauren E.; Teti, Douglas M.

    2016-01-01

    In keeping with transactional conceptualizations of infant sleep development (Sadeh et al., 2010), the present study examined longitudinal, bidirectional linkages between bedtime parenting (direct observations of parenting practices and quality) and infant sleep across the first six months postpartum. In doing so, we also drew from Darling and Steinberg's (1993) conceptual model to examine parenting quality as a moderator of linkages between specific bedtime practices and infant sleep. Multilevel model analyses revealed that the strongest increases in infant nighttime sleep across the first six months occurred among infants of mothers who engaged in low levels of nursing at bedtime. Within-person linkages between mothers' emotional availability (EA) at bedtime, infant distress, and infant sleep were found, such that at time points when mothers were more emotionally available, infants were less distressed and slept more throughout the night. Several moderating effects of maternal EA on linkages between parenting practices and infant sleep were obtained that were consistent with predictions from Darling and Steinberg (1993). Higher maternal EA in combination with less close contact at bedtime was associated with more infant sleep across the night on average, and higher EA in combination with fewer arousing bedtime activities predicted more rapid increases in infant sleep with age. Finally, there was evidence of infant-driven effects, as higher infant nighttime distress predicted lower EA at subsequent time points. Results showcased the complex, reciprocal interplay between parents and infants in the development of infant sleep patterns and parenting behavior during the first six months postpartum. PMID:27010601

  1. Letramentos acadêmicos e multimodalidade em contexto de EaD semipresencial

    Directory of Open Access Journals (Sweden)

    Fabiana Komesu

    2012-07-01

    Full Text Available De uma perspectiva teórica enunciativo-discursiva, este artigo tem como objetivo discutir o processo de constituição do texto em contexto digital, de maneira particularizada, por meio da problematização de modos e recursos semióticos atualizados na produção acadêmica do universitário que utiliza computador com acesso à internet no processo de Educação a Distância (EaD semipresencial. Interessa investigar como o modelo de letramentos acadêmicos pode ser articulado ao estudo da multimodalidade, considerando-se que em ambiente eletrônico o universitário tem, por hipótese, acesso “ilimitado” a todo e qualquer texto, não apenas ao chamado “verbal”, comumente atribuído ao elemento gráfico. O conjunto do material é formado de textos produzidos por alunos do Curso de Pedagogia semipresencial da Universidade Virtual do Estado de São Paulo (UNIVESP no ano de 2010.Palavras-chave: Escrita. Letramentos. Discurso. Educação a distância. Internet.

  2. Low modulation bias InGaN-based integrated EA-modulator-laser on semipolar GaN substrate

    KAUST Repository

    Shen, Chao

    2015-10-06

    In summary, we demonstrated the monolithic integration of electroabsorption modulator with laser diode and measured DC and AC modulation characteristics of the device, which is grown on (2021̅) plane GaN substrate. By alternating the modulation voltage at −3.5 V and 0 V, we achieve the laser output power of < 1.5 mW to > 9 mW, respectively, leading to ∼8.1 dB On/Off ratio. Our results clearly show that a low power consumption modulator can be achieved with semipolar EA-modulator compared to that of the c-plane devices.

  3. Low modulation bias InGaN-based integrated EA-modulator-laser on semipolar GaN substrate

    KAUST Repository

    Shen, Chao; Leonard, John; Pourhashemi, Arash; Oubei, Hassan M.; Alias, Mohd Sharizal; Ng, Tien Khee; Nakamura, Shuji; DenBaars, Steven P.; Speck, James S.; Alyamani, Ahmed Y.; Eldesouki, Munir M.; Ooi, Boon S.

    2015-01-01

    In summary, we demonstrated the monolithic integration of electroabsorption modulator with laser diode and measured DC and AC modulation characteristics of the device, which is grown on (2021̅) plane GaN substrate. By alternating the modulation voltage at −3.5 V and 0 V, we achieve the laser output power of < 1.5 mW to > 9 mW, respectively, leading to ∼8.1 dB On/Off ratio. Our results clearly show that a low power consumption modulator can be achieved with semipolar EA-modulator compared to that of the c-plane devices.

  4. A longitudinal study of occlusal caries in Newark New Jersey school children: relationship between initial dental finding and the development of new lesions

    Science.gov (United States)

    Markowitz, Kenneth; Fairlie, Karen; Ferrandiz, Javier; Nasri-Heir, Cibele

    2012-01-01

    Objective Dental caries is a significant public health problem especially amongst children from low-income backgrounds. This longitudinal study examined the development of new occlusal caries in 227 Newark, NJ children ages 10–18. The role of previous caries experience and the presence of occlusal white and dark lesions in predicting the development of new lesions were examined. Design At each visit, the patient’s teeth were given a visual-tactile examination and the subject’s decayed; missing and filled (DMFS) score was determined. Next, molars lacking probeable caries or restorations were examined using transillumination for occlusal white and dark spots. This examination was repeated periodically. A Cox proportional hazard was used to analyze data concerning the development of new occusal caries in molars. Results The longitudinal data indicates that patients who were caries free at visit-1 developed significantly fewer occlusal caries during the longitudinal study. The hazard ratio for subjects who had first-visit caries was 2.27 compared to caries free subjects. Intact molars with occlusal white or dark lesions had caries hazard ratios of 0.78 and 1.49 respectively, compared to molars lacking initial color changes. Conclusion Having a prior caries history places the subject at increased risk of developing future caries. Teeth with dark lesions but not white lesions are at significantly increased risk for developing decay. White lesions may represent remineralizing or slowly progressing lesions. The results of this study can help identify patients and tooth surfaces at risk for future occlusal decay. PMID:22841633

  5. Study of the peripheral projectile-like fragments from the reaction 129Xe on 27Al, natCu, 139La and 165Ho, at E/A = 50 MeV

    International Nuclear Information System (INIS)

    Garcia-Solis, E.J.; Russ, D.E.; Madani, H.

    1996-01-01

    There are several reaction mechanisms identified for peripheral heavy-ion collisions. For low bombarding energies (E/A ∼ 10 MeV) the predominant reaction channel is the deep-inelastic reaction mechanism. In this process, the projectile and target form a rotating binary system, interchanging nucleons and angular momentum until they separate. At higher bombarding energies (E/A ∼ 50 to 100 MeV) incomplete fusion is thought to be the prevailing reaction channel. In this type of interaction part of the projectile merges with the target during the collision. Finally, for energies greater than 100 MeV/A, the main reaction channel is characterized by the formation of a highly-excited separate fragment (fireball) produced during the overlap between the projectile and the target. The data set studied was from an experiment designed to characterize the projectile-like products of the 27 Al, nat Cu, 139 La, and 165 Ho reactions at E/A = 50 MeV, which was performed at the Michigan State University Super Cyclotron Laboratory (MSU-NSCL). The Maryland Forward Array (MFA), was used to measure projectile-like fragments in coincidence with target-like fragments and light-charge particles in the MSU 4π detector

  6. Physical Activity and Personality Development over Twenty Years: Evidence from Three Longitudinal Samples.

    Science.gov (United States)

    Stephan, Yannick; Sutin, Angelina R; Luchetti, Martina; Bosselut, Grégoire; Terracciano, Antonio

    2018-04-01

    A physically inactive lifestyle is associated with maladaptive patterns of personality development over relatively short follow-up periods. The present study extends existing research by examining whether this association persists over 20 years. Participants (total N = 8,723) were drawn from the Wisconsin Longitudinal Study Graduates and Siblings samples and the Midlife in the United States Study. Controlling for demographic factors and disease burden, baseline physical inactivity was related to steeper declines in conscientiousness in all three samples and a meta-analysis (β=-.06). The meta-analysis further showed that lower physical activity was associated with declines in openness (β=-.05), extraversion (β=-.03), and agreeableness (β=-.03). These findings provide evidence that a physically inactive lifestyle is associated with long-term detrimental personality trajectories.

  7. Longitudinal-bending mode micromotor using multilayer piezoelectric actuator.

    Science.gov (United States)

    Yao, K; Koc, B; Uchino, K

    2001-07-01

    Longitudinal-bending mode ultrasonic motors with a diameter of 3 mm were fabricated using stacked multilayer piezoelectric actuators, which were self-developed from hard lead zirconate titanate (PZT) ceramic. A bending vibration was converted from a longitudinal vibration with a longitudinal-bending coupler. The motors could be bidirectionally operated by changing driving frequency. Their starting and braking torque were analyzed based on the transient velocity response. With a load of moment of inertia 2.5 x 10(-7) kgm2, the motor showed a maximum starting torque of 127.5 microNm. The braking torque proved to be a constant independent on the motor's driving conditions and was roughly equivalent to the maximum starting torque achievable with our micromotors.

  8. Representaciones culturales de países hispanohablantes: una mirada a los recursos visuales en el contexto de EaD

    Directory of Open Access Journals (Sweden)

    Leandra Cristina de Oliveira

    2017-09-01

    Full Text Available Con vistas a la relevancia de la discusión sobre cultura en la Lingüística Aplicada, tanto en el ámbito de la enseñanza de lengua materna como de lengua extranjera, direccionamos el diálogo sobre el tema a la enseñanza de español en la Educación a Distancia (EaD. Observando el Curso de Letras Español de la Universidad Federal de Santa Catarina, en la modalidad EaD, objetivamos discutir las representaciones culturales de los países hispanohablantes en las imágenes del Ambiente virtual de la asignatura Lengua Española I. Consonante al objetivo, asentamos la siguiente cuestión: ¿en qué medida las representaciones culturales en las imágenes analizadas contribuyen para la desconstrucción de concepciones reduccionistas y estereotipadas sobre los países hispanohablantes? La respuesta a esta cuestión procede del análisis de las imágenes introductorias de los tópicos de la asignatura citada, fundamentada en bases teóricas de estudios culturales, con especial atención a los conceptos de cultura, identidad y diferencia.

  9. Real-Time Engagement Area Development Program (READ-Pro)

    National Research Council Canada - National Science Library

    Burger, Joseph

    2002-01-01

    The Real Time Engagement Area Development Program (READ-Pro) is a PC-based prototype system which provides company-level commanders with real-time operational analysis tools to develop ENGAGEMENT AREAS(EA) for direct fire (DF) systems...

  10. Development of Inflammatory Bowel Disease Is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice

    OpenAIRE

    Sharpton, T; Lyalina, S; Luong, J; Pham, J; Deal, EM; Armour, C; Gaulke, C; Sanjabi, S; Pollard, KS

    2017-01-01

    ABSTRACT The gut microbiome is linked to inflammatory bowel disease (IBD) severity and altered in late-stage disease. However, it is unclear how gut microbial communities change over the course of IBD development, especially in regard to function. To investigate microbiome-mediated disease mechanisms and discover early biomarkers of IBD, we conducted a longitudinal metagenomic investigation in an established mouse model of IBD, where damped transforming growth factor ? (TGF-?) signaling in T ...

  11. Development of Inflammatory Bowel Disease is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice

    OpenAIRE

    Luong, Julie; Sharpton, Thomas; Pollard, Katherine; Sanjabi, Shomyseh; Gaulke, Christopher; Armour, Courtney; Deal, Emily; Pham, Joey; Loung, Julie; Lyalina, Svetlana; Sharpton, Thomas

    2017-01-01

    The gut microbiome is linked to inflammatory bowel disease (IBD) severity and altered in late stage disease. However, it is unclear how gut microbial communities change over the course of IBD development, especially in regards to function. To investigate microbiome mediated disease mechanisms and discover early biomarkers of IBD, we conducted a longitudinal metagenomic investigation in an established mouse model of IBD, where dampened TGF-β signaling in T cells leads to peripheral immune acti...

  12. Sequential Progressions in a Theory-of-Mind Scale: Longitudinal Perspectives

    Science.gov (United States)

    Wellman, Henry M.; Fang, Fuxi; Peterson, Candida C.

    2011-01-01

    Consecutive retestings of 92 U.S. preschoolers (n = 30), Chinese preschoolers (n = 31), and deaf children (n = 31) examined whether the sequences of development apparent in cross-sectional results with a theory-of-mind scale also appeared in longitudinal assessment. Longitudinal data confirmed that theory-of-mind progressions apparent in…

  13. Modelling, simulation and applications of longitudinal train dynamics

    Science.gov (United States)

    Cole, Colin; Spiryagin, Maksym; Wu, Qing; Sun, Yan Quan

    2017-10-01

    Significant developments in longitudinal train simulation and an overview of the approaches to train models and modelling vehicle force inputs are firstly presented. The most important modelling task, that of the wagon connection, consisting of energy absorption devices such as draft gears and buffers, draw gear stiffness, coupler slack and structural stiffness is then presented. Detailed attention is given to the modelling approaches for friction wedge damped and polymer draft gears. A significant issue in longitudinal train dynamics is the modelling and calculation of the input forces - the co-dimensional problem. The need to push traction performances higher has led to research and improvement in the accuracy of traction modelling which is discussed. A co-simulation method that combines longitudinal train simulation, locomotive traction control and locomotive vehicle dynamics is presented. The modelling of other forces, braking propulsion resistance, curve drag and grade forces are also discussed. As extensions to conventional longitudinal train dynamics, lateral forces and coupler impacts are examined in regards to interaction with wagon lateral and vertical dynamics. Various applications of longitudinal train dynamics are then presented. As an alternative to the tradition single wagon mass approach to longitudinal train dynamics, an example incorporating fully detailed wagon dynamics is presented for a crash analysis problem. Further applications of starting traction, air braking, distributed power, energy analysis and tippler operation are also presented.

  14. A Study of the Factors Associated with Risk for Development of Pressure Ulcers: A Longitudinal Analysis.

    Science.gov (United States)

    Thomas, Elizebeth; Vinodkumar, Sudhaya; Mathew, Silvia; Setia, Maninder Singh

    2015-01-01

    Pressure ulcers (PUs) are prevalent in hospitalized patients; they may cause clinical, psychological, and economic problems in these patients. Previous studies are cross-sectional, have used pooled data, or cox-regression models to assess the risk for developing PU. However, PU risk scores change over time and models that account for time varying variables are useful for cohort analysis of data. The present longitudinal study was conducted to compare the risk of PU between surgical and nonsurgical patients, and to evaluate the factors associated with the development of these ulcers over a period of time. We evaluated 290 hospitalized patients over a 4 months period. The main outcomes for our analysis were: (1) Score on the pressure risk assessment scale; and (2) the proportion of individuals who were at severe risk for developing PUs. We used random effects models for longitudinal analysis of the data. The mean PU score was significantly higher in the nonsurgical patients compared with surgical patients at baseline (15.23 [3.86] vs. 9.33 [4.57]; P 20 at baseline and were considered as being at high-risk for PU; the proportion was significantly higher among the nonsurgical patients compared with the surgical patients (14% vs. 4%, P = 0.003). In the adjusted models, there was no difference for severe risk for PU between surgical and nonsurgical patients (odds ratios [ORs]: 0.37, 95% confidence interval [CI]: 0.01-12.80). An additional day in the ward was associated with a significantly higher likelihood of being at high-risk for PU (OR: 1.47, 95% CI: 1.16-1.86). There were no significant differences between patients who were admitted for surgery compared with those who were not. An additional day in the ward, however, is important for developing a high-risk score for PU on the monitoring scale, and these patients require active interventions.

  15. The longitudinal development of showers induced by high-energy hadrons in an iron-sampling calorimeter

    CERN Document Server

    Milke, J; Apel, W D; Badea, F; Bekk, K; Bercuci, A; Bertaina, M; Blümer, H; Bozdog, H; Büttner, C; Chiavassa, A; Daumiller, K; Di Pierro, F; Dolla, P; Engel, R; Engler, J; Fessler, F; Ghia, P L; Gils, H J; Glasstetter, R; Haungs, A; Heck, D; Hörandel, J R; Kampert, K H; Klages, H O; Kolotaev, Yu; Maier, G; Mathes, H J; Mayer, H J; Mitrica, B; Morello, C; Müller, M; Navarra, G; Obenland, R; Oehlschläger, J; Ostapchenko, S; Over, S; Petcu, M; Plewnia, S; Rebel, H; Risse, A; Roth, M; Schieler, H; Scholz, J; Stümpert, M; Thouw, T; Toma, G; Trinchero, G C; Ulrich, H; Valchierotti, S; Van Buren, J; Walkowiak, W; Weindl, A; Wochele, J; Zabierowski, J; Zagromski, S; Zimmermann, D

    2005-01-01

    Occasionally cosmic-ray induced air showers result in single, unaccompanied hadrons at ground level. Such events are investigated with the 300 m2 hadron calorimeter of the KASCADE-Grande experiment. It is an iron sampling calorimeter with a depth of 11 hadronic interaction lengths read out by warm-liquid ionization chambers. The longitudinal shower development is discussed as function of energy up to 30 TeV and the results are compared with simulations using the GEANT/FLUKA code. In addition, results of test measurements at a secondary particle beam of the Super Proton Synchrotron at CERN up to 350 GeV are discussed.

  16. Night awakening in infancy: Developmental stability and longitudinal associations with psychomotor development.

    Science.gov (United States)

    Mäkelä, Tiina E; Peltola, Mikko J; Nieminen, Pirkko; Paavonen, E Juulia; Saarenpää-Heikkilä, Outi; Paunio, Tiina; Kylliäinen, Anneli

    2018-03-29

    Fragmented sleep is common in infancy. Although night awakening is known to decrease with age, in some infants night awakening is more persistent and continues into older ages. However, the influence of fragmented sleep on development is poorly known. In the present study, the longitudinal relationship between fragmented sleep and psychomotor development (Bayley Scales of Infant and Toddler Development [Bayley-III]; Bayley, 2009) was investigated in infants with (≥3 night awakenings, n = 81) and without fragmented sleep (≤1 night awakening, n = 70) within the CHILD-SLEEP birth cohort at 8 and 24 months of age. Differences in parent-reported (Brief Infant Sleep Questionnaire [BISQ]) sleep parameters were studied at 8, 18, and 24 months of age. Group differences in night awakening were stable across all assessment points. Infants with fragmented sleep slept less in total than infants without fragmented sleep and they did not compensate their nocturnal sleep during daytime. Additionally, infants with fragmented sleep spent more time awake at night than infants without fragmented sleep. However, psychomotor development did not differ between infants with and without fragmented sleep at 8 or 24 months of age. Our findings indicate that early onset fragmented sleep did not have a negative effect on psychomotor development within the first 2 years despite the differences in sleep length among infants with and without fragmented sleep. In the future, more specific domains of cognitive development and various factors affecting sleep fragmentation should be taken into account when studying the developmental effects of night awakening in infancy. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  17. Exploring Longitudinal Risk-return Relationships

    DEFF Research Database (Denmark)

    Andersen, Torben J.; Bettis, Richard A.

    2015-01-01

    We study a longitudinal fit model of adaptation and its association with the longitudinal risk-return relationship. The model allows the firm to adjust its position in response to partial learning about a changing environment characterized by two path-dependent processes—a random walk and a stoch......We study a longitudinal fit model of adaptation and its association with the longitudinal risk-return relationship. The model allows the firm to adjust its position in response to partial learning about a changing environment characterized by two path-dependent processes—a random walk...... can lead to the inverse longitudinal risk-return relationships observed empirically. We discuss this apparent paradox and the possible resolution between mindless and conscious behavior as plausible causes of the longitudinal Bowman Paradox....

  18. Body Size at Birth, Physical Development and Cognitive Outcomes in Early Childhood: Evidence from the Longitudinal Survey of Australian Children

    Science.gov (United States)

    Ulker, Aydogan

    2016-01-01

    Using a rich sample created from the Longitudinal Survey of Australian Children, we investigate the extent to which the relationship between body size at birth and early childhood cognitive skills is mediated by physical development indicators. Consistent with existing evidence from other countries, we find a significant relationship between body…

  19. Frontoparietal Structural Connectivity in Childhood Predicts Development of Functional Connectivity and Reasoning Ability: A Large-Scale Longitudinal Investigation.

    Science.gov (United States)

    Wendelken, Carter; Ferrer, Emilio; Ghetti, Simona; Bailey, Stephen K; Cutting, Laurie; Bunge, Silvia A

    2017-08-30

    Prior research points to a positive concurrent relationship between reasoning ability and both frontoparietal structural connectivity (SC) as measured by diffusion tensor imaging (Tamnes et al., 2010) and frontoparietal functional connectivity (FC) as measured by fMRI (Cocchi et al., 2014). Further, recent research demonstrates a link between reasoning ability and FC of two brain regions in particular: rostrolateral prefrontal cortex (RLPFC) and the inferior parietal lobe (IPL) (Wendelken et al., 2016). Here, we sought to investigate the concurrent and dynamic, lead-lag relationships among frontoparietal SC, FC, and reasoning ability in humans. To this end, we combined three longitudinal developmental datasets with behavioral and neuroimaging data from 523 male and female participants between 6 and 22 years of age. Cross-sectionally, reasoning ability was most strongly related to FC between RLPFC and IPL in adolescents and adults, but to frontoparietal SC in children. Longitudinal analysis revealed that RLPFC-IPL SC, but not FC, was a positive predictor of future changes in reasoning ability. Moreover, we found that RLPFC-IPL SC at one time point positively predicted future changes in RLPFC-IPL FC, whereas, in contrast, FC did not predict future changes in SC. Our results demonstrate the importance of strong white matter connectivity between RLPFC and IPL during middle childhood for the subsequent development of both robust FC and good reasoning ability. SIGNIFICANCE STATEMENT The human capacity for reasoning develops substantially during childhood and has a profound impact on achievement in school and in cognitively challenging careers. Reasoning ability depends on communication between lateral prefrontal and parietal cortices. Therefore, to understand how this capacity develops, we examined the dynamic relationships over time among white matter tracts connecting frontoparietal cortices (i.e., structural connectivity, SC), coordinated frontoparietal activation

  20. Development and Validation of a Risk Scale for Emergence Agitation After General Anesthesia in Children: A Prospective Observational Study.

    Science.gov (United States)

    Hino, Maai; Mihara, Takahiro; Miyazaki, Saeko; Hijikata, Toshiyuki; Miwa, Takaaki; Goto, Takahisa; Ka, Koui

    2017-08-01

    Emergence agitation (EA) is a common complication in children after general anesthesia. The goal of this 2-phase study was (1) to develop a predictive model (EA risk scale) for the incidence of EA in children receiving sevoflurane anesthesia by performing a retrospective analysis of data from our previous study (phase 1) and (2) to determine the validity of the EA risk scale in a prospective observational cohort study (phase 2). Using data collected from 120 patients in our previous study, logistic regression analysis was used to predict the incidence of EA in phase 1. The optimal combination of the predictors was determined by a stepwise selection procedure using Akaike information criterion. The β-coefficient for the selected predictors was calculated, and scores for predictors determined. The predictive ability of the EA risk scale was assessed by a receiver operating characteristic (ROC) curve, and the area under the ROC curve (c-index) was calculated with a 95% confidence interval (CI). In phase 2, the validity of the EA risk scale was confirmed using another data set of 100 patients (who underwent minor surgery under general anesthesia). The ROC curve, the c-index, the best cutoff point, and the sensitivity and specificity at the point were calculated. In addition, we calculated the gray zone, which ranges between the two points where sensitivity and specificity, respectively, become 90%. In phase 1, the final model of the multivariable logistic regression analysis included the following 4 predictors: age (logarithm odds ratios [OR], -0.38; 95% CI, -0.81 to 0.00), Pediatric Anesthesia Behavior score (logarithm OR, 0.65; 95% CI, -0.09 to 1.40), anesthesia time (logarithm OR, 0.60; 95% CI, -0.18 to 1.19), and operative procedure (logarithm OR, 2.53; 95% CI, 1.30-3.75 for strabismus surgery and logarithm OR, 2.71; 95% CI, 0.99-4.45 for tonsillectomy). The EA risk scale included these 4 predictors and ranged from 1 to 23 points. In phase 2, the incidence of EA

  1. Statistical methods for longitudinal data with agricultural applications

    DEFF Research Database (Denmark)

    Anantharama Ankinakatte, Smitha

    The PhD study focuses on modeling two kings of longitudinal data arising in agricultural applications: continuous time series data and discrete longitudinal data. Firstly, two statistical methods, neural networks and generalized additive models, are applied to predict masistis using multivariate...... algorithm. This was found to compare favourably with the algorithm implemented in the well-known Beagle software. Finally, an R package to apply APFA models developed as part of the PhD project is described...

  2. Energy balance-related behavioural patterns in 5-year-old children and the longitudinal association with weight status development in early childhood

    NARCIS (Netherlands)

    Gubbels, J.S.; Kremers, S.P.J.; Goldbohm, R.A.; Stafleu, A.; Thijs, C.

    2012-01-01

    Objective The current study examined clustering of dietary intake and activity behaviours (i.e. physical activity (PA) and sedentary behaviour) in 5-year-old children, as well as the longitudinal association with BMI and overweight development. Design Principal component analysis (PCA) was used to

  3. Energy balance-related behavioural patterns in 5-year-old children and the longitudinal association with weight status development in early childhood

    NARCIS (Netherlands)

    Gubbels, J.S.; Kremers, S.P.; Goldbohm, R.A.; Stafleu, A.

    2012-01-01

    OBJECTIVE: The current study examined clustering of dietary intake and activity behaviours (i.e. physical activity (PA) and sedentary behaviour) in 5-year-old children, as well as the longitudinal association with BMI and overweight development.DESIGN: Principal component analysis (PCA) was used to

  4. Longitudinal research and data collection in primary care.

    Science.gov (United States)

    van Weel, Chris

    2005-01-01

    This article reviews examples of and experience with longitudinal research in family medicine. The objective is to use this empirical information to formulate recommendations for improving longitudinal research. The article discusses 3 longitudinal studies from the Nijmegen academic family practice research network: 1 on the prognosis of depression and 1 each on the prognosis of and outcomes of care for type 2 diabetes mellitus. The Nijmegen network has recorded all episodes of morbidity encountered in Dutch family medicine since 1971 in a stable practice population. This network's experience is evaluated to identify lessons that may help other practice-based research networks (PBRNs) in pursuing longitudinal research. In terms of external conditions (conditions related to the general setting), the stability of a population and a high level of continuity of care substantially enhance the ability to perform longitudinal research. In terms of internal conditions (conditions related to the PBRN), motivation of family physicians and their staff to conduct ongoing data collection, and their ownership of the data are key for success. Other critical internal conditions include standardization of data; collection of data by clinician-friendly means; training of family physicians and their staff in data collection, as well as meetings for discussion of this task; provision of feedback to practices on the research findings; use of standard procedures to promote adherence to data collection; availability of facilities for regular measurement of patients' health status or chart review; and use of mechanisms for tracking patients who leave the practice area. Insight from existing experience suggests that longitudinal research can be enhanced in PBRNs. The best way forward is to build longitudinal data collection by drawing on lessons from successful studies. Primary care research policy should advocate for a role of longitudinal research and stimulate its development in PBRNs

  5. Carbon-13 composition of bulk dry wines by irm-EA/MS and irm-13C NMR: An indicator of vine water status

    Directory of Open Access Journals (Sweden)

    Guyon Francois

    2017-01-01

    Full Text Available Measurements performed on a set of 32 authentic wines (not submitted to any oenological treatment and their ethanol, recovered by distillation, show high correlation between δ13C of bulk wine and its ethanol. These measurements were performed by isotope ratio monitoring by mass spectrometry coupled to an elemental analyzer (irm-EA/MS. Then a series of wines produced by vines of which water status was assessed during the growing season with predawn leaf water potential measurements, was studied by irm-EA/MS. As expected δ13C is correlated to vine water status conditions, as a result of stomatal closure. The ethanol of these specific wines was also analyzed by isotope ratio monitoring and by nuclear magnetic resonance (irm-13C NMR to determine carbon-13 composition on the two specific sites of the ethanol skeleton. If these measurements confirm the correlation between 13C composition and vine growth conditions, the 13C stereospecific information does not make vine water status assessment more precise.

  6. Physical Activity and Personality Development over Twenty Years: Evidence from Three Longitudinal Samples

    Science.gov (United States)

    Stephan, Yannick; Sutin, Angelina R.; Luchetti, Martina; Bosselut, Grégoire; Terracciano, Antonio

    2018-01-01

    A physically inactive lifestyle is associated with maladaptive patterns of personality development over relatively short follow-up periods. The present study extends existing research by examining whether this association persists over 20 years. Participants (total N = 8,723) were drawn from the Wisconsin Longitudinal Study Graduates and Siblings samples and the Midlife in the United States Study. Controlling for demographic factors and disease burden, baseline physical inactivity was related to steeper declines in conscientiousness in all three samples and a meta-analysis (β=−.06). The meta-analysis further showed that lower physical activity was associated with declines in openness (β=−.05), extraversion (β=−.03), and agreeableness (β=−.03). These findings provide evidence that a physically inactive lifestyle is associated with long-term detrimental personality trajectories. PMID:29651189

  7. Smoking is associated with impaired bone mass development in young adult men: a 5-year longitudinal study.

    Science.gov (United States)

    Rudäng, Robert; Darelid, Anna; Nilsson, Martin; Nilsson, Staffan; Mellström, Dan; Ohlsson, Claes; Lorentzon, Mattias

    2012-10-01

    It has previously been shown that smoking is associated with reduced bone mass and increased fracture risk, but no longitudinal studies have been published investigating altered smoking behavior at the time of bone mass acquisition. The aim of this study was to investigate the development of bone density and geometry according to alterations in smoking behavior in a 5-year, longitudinal, population-based study of 833 young men, age 18 to 20 years (baseline). Furthermore, we aimed to examine the cross-sectional, associations between current smoking and parameters of trabecular microarchitecture of the radius and tibia, using high-resolution peripheral quantitative computed tomography (HR-pQCT), in young men aged 23 to 25 years (5-year follow-up). Men who had started to smoke since baseline had considerably smaller increases in areal bone mineral density (aBMD) at the total body (mean ± SD, 0.020 ± 0.047 mg/cm(2) versus 0.043 ± 0.040 mg/cm(2) , p young adulthood have poorer development of their aBMD at clinically important sites such as the spine and hip than nonsmokers, possibly due to augmented loss of trabecular density and impaired growth of cortical cross-sectional area. Copyright © 2012 American Society for Bone and Mineral Research.

  8. Causal mediation analysis for longitudinal data with exogenous exposure

    OpenAIRE

    Bind, M.-A. C.; Vanderweele, T. J.; Coull, B. A.; Schwartz, J. D.

    2015-01-01

    Mediation analysis is a valuable approach to examine pathways in epidemiological research. Prospective cohort studies are often conducted to study biological mechanisms and often collect longitudinal measurements on each participant. Mediation formulae for longitudinal data have been developed. Here, we formalize the natural direct and indirect effects using a causal framework with potential outcomes that allows for an interaction between the exposure and the mediator. To allow different type...

  9. Longitudinal Study of the Social Network Influences on the Leadership and Professional Military Development of Cadets at the U.S. Air Force Academy

    National Research Council Canada - National Science Library

    Packard, Gary

    1999-01-01

    .... Using a longitudinal design over an academic year (August 1997 to May 1998), the study examined the differences in the composition of cadet social groups and their influence on leadership development in two cadet squadrons...

  10. High-precision determination of 18O/16O ratios of silver phosphate by EA-pyrolysis-IRMS continuous flow technique.

    Science.gov (United States)

    Lécuyer, Christophe; Fourel, François; Martineau, François; Amiot, Romain; Bernard, Aurélien; Daux, Valérie; Escarguel, Gilles; Morrison, John

    2007-01-01

    A high-precision, and rapid on-line method for oxygen isotope analysis of silver phosphate is presented. The technique uses high-temperature elemental analyzer (EA)-pyrolysis interfaced in continuous flow (CF) mode to an isotopic ratio mass spectrometer (IRMS). Calibration curves were generated by synthesizing silver phosphate with a 13 per thousand spread in delta(18)O values. Calibration materials were obtained by reacting dissolved potassium dihydrogen phosphate (KH(2)PO(4)) with water samples of various oxygen isotope compositions at 373 K. Validity of the method was tested by comparing the on-line results with those obtained by classical off-line sample preparation and dual inlet isotope measurement. In addition, silver phosphate precipitates were prepared from a collection of biogenic apatites with known delta(18)O values ranging from 12.8 to 29.9 per thousand (V-SMOW). Reproducibility of +/- 0.2 per thousand was obtained by the EA-Py-CF-IRMS method for sample sizes in the range 400-500 microg. Both natural and synthetic samples are remarkably well correlated with conventional (18)O/(16)O determinations. Silver phosphate is a very stable material and easy to degas and, thus, could be considered as a good candidate to become a reference material for the determination of (18)O/(16)O ratios of phosphate by high-temperature pyrolysis. Copyright 2006 John Wiley & Sons, Ltd.

  11. Longitudinal halo in beam bunches with self-consistent 6-D distributions

    International Nuclear Information System (INIS)

    Gluckstern, R. L.; Fedotov, A. V.; Kurennoy, S. S.; Ryne, R. D.

    1998-01-01

    We have explored the formation of longitudinal and transverse halos in 3-D axisymmetric beam bunches by starting with a self-consistent 6-D phase space distribution. Stationary distributions allow us to study the halo development mechanism without being obscured by beam redistribution and its effect on halo formation. The beam is then mismatched longitudinally and/or transversely, and we explore the rate, intensity and spatial extent of the halos which form, as a function of the beam charge and the mismatches. We find that the longitudinal halo forms first because the longitudinal tune depression is more severe than the transverse one for elongated bunches and conclude that it plays a major role in halo formation

  12. MENTAL STATE LANGUAGE DEVELOPMENT: THE LONGITUDINAL ROLES OF ATTACHMENT AND MATERNAL LANGUAGE.

    Science.gov (United States)

    Becker Razuri, Erin; Hiles Howard, Amanda R; Purvis, Karyn B; Cross, David R

    2017-05-01

    Maternal mental state language is thought to influence children's mental state language and sociocognitive understanding (e.g., theory of mind), but the mechanism is unclear. The current study examined the longitudinal development of mental state language in mother-child interactions. The methodology included assessments of the child and/or mother-child dyad at six time points between 12 to 52 months of the child's age. Measures determined child's attachment style and language abilities, and mental state language used by mother and child during a block-building task. Results showed that (a) mental state talk, including belief and desire language, increased over time; (b) there were differences between the type of mental state words used by the mother in insecure versus secure dyads; (c) there were differences in patterns of mental state words used in both mothers and children in insecure versus secure dyads; and (d) attachment appeared to exert a consistent influence over time. © 2017 Michigan Association for Infant Mental Health.

  13. Bidirectional associations between bedtime parenting and infant sleep: Parenting quality, parenting practices, and their interaction.

    Science.gov (United States)

    Philbrook, Lauren E; Teti, Douglas M

    2016-06-01

    In keeping with transactional conceptualizations of infant sleep development (Sadeh, Tikotzky, & Scher, 2010), the present study was an examination of longitudinal, bidirectional linkages between bedtime parenting (through direct observations of parenting practices and quality) and infant sleep across the first 6 months postpartum. In doing so, we also drew from Darling and Steinberg's (1993) conceptual model to examine parenting quality as a moderator of linkages between specific bedtime practices and infant sleep. Multilevel model analyses revealed that the strongest increases in infant nighttime sleep across the first 6 months occurred among infants of mothers who engaged in low levels of nursing at bedtime. Within-person linkages between mothers' emotional availability (EA) at bedtime, infant distress, and infant sleep were found, such that at time points when mothers were more emotionally available, infants were less distressed and slept more throughout the night. Several moderating effects of maternal EA on linkages between parenting practices and infant sleep were obtained that were consistent with predictions from Darling and Steinberg (1993). Higher maternal EA in combination with less close contact at bedtime was associated with more infant sleep across the night on average, and higher EA in combination with fewer arousing bedtime activities predicted more rapid increases in infant sleep with age. Finally, there was evidence of infant-driven effects, as higher infant nighttime distress predicted lower EA at subsequent time points. Results showcased the complex, reciprocal interplay between parents and infants in the development of infant sleep patterns and parenting behavior during the first 6 months postpartum. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  14. Uncovering the factors that can support and impede post-disaster EIA practice in developing countries: The case of Aceh Province, Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Gore, Tom; Fischer, Thomas B., E-mail: fischer@liverpool.ac.uk

    2014-01-15

    The close relationship between environmental degradation and the occurrence and severity of disaster events has in recent years raised the profile of environmental assessment (EA) in the disaster management field. EA has been identified as a potentially supportive tool in the global effort to reduce disaster risk. As a component of this, attention has been brought specifically to the importance of the application of EA in the aftermath of disaster events in order to help prevent recurrence and promote sustainability. At the same time, however, it has also been recognised that post-disaster environments may be unfavourable to such practices. Looking at the practice of environmental impact assessment (EIA), this paper reports on a study which sought to identify more specifically the factors which can both support and hinder such practice following disaster events in a developing country context. Analysing the situation in Aceh Province, Indonesia, after the impact of two tsunamigenic earthquakes in late 2004 and early 2005, it is concluded that if EIA is to have a central role in the post-disaster period, pre-disaster preparation could be a key. -- Highlights: • Close relationship between environmental degradation and occurrence/severity of disaster events has raised profile of EA. • EA as a potentially supportive tool in the global effort to reduce disaster risk • Application of EA in the aftermath of disaster events to help prevent recurrence and promote sustainability • The paper looks at factors which can both support and hinder EA following disaster events in a developing country context. • We analyse the situation in Aceh Province, Indonesia, after the impact of two tsunamigenic earthquakes in 2004 and 2005.

  15. A Longitudinal Study of Child Siblings and Theory of Mind Development

    Science.gov (United States)

    McAlister, Anna; Peterson, Candida

    2007-01-01

    This study tested a sample of 63 children twice in a longitudinal design over 14 months to examine their theory-of-mind (ToM) understanding in relation to their number of child-aged siblings (1-12 years). Age-appropriate batteries of ToM tests emphasising false belief were given at the start of the study, when children had a mean age of 4-2…

  16. Longitudinal Losses Due to Breathing Mode Excitation in Radiofrequency Linear Accelerators

    OpenAIRE

    Channell, Paul J.

    2010-01-01

    Transverse breathing mode oscillations in a particle beam can couple energy into longitudinal oscillations in a bunch of finite length and cause significant losses. We develop a model that illustrates this effect and explore the dependence on mismatch size, space-charge tune depression, longitudinal focusing strength, bunch length, and RF bucket length.

  17. A Multi-Institutional Longitudinal Faculty Development Program in Humanism Supports the Professional Development of Faculty Teachers.

    Science.gov (United States)

    Branch, William T; Frankel, Richard M; Hafler, Janet P; Weil, Amy B; Gilligan, MaryAnn C; Litzelman, Debra K; Plews-Ogan, Margaret; Rider, Elizabeth A; Osterberg, Lars G; Dunne, Dana; May, Natalie B; Derse, Arthur R

    2017-12-01

    The authors describe the first 11 academic years (2005-2006 through 2016-2017) of a longitudinal, small-group faculty development program for strengthening humanistic teaching and role modeling at 30 U.S. and Canadian medical schools that continues today. During the yearlong program, small groups of participating faculty met twice monthly with a local facilitator for exercises in humanistic teaching, role modeling, and related topics that combined narrative reflection with skills training using experiential learning techniques. The program focused on the professional development of its participants. Thirty schools participated; 993 faculty, including some residents, completed the program.In evaluations, participating faculty at 13 of the schools scored significantly more positively as rated by learners on all dimensions of medical humanism than did matched controls. Qualitative analyses from several cohorts suggest many participants had progressed to more advanced stages of professional identity formation after completing the program. Strong engagement and attendance by faculty participants as well as the multimodal evaluation suggest that the program may serve as a model for others. Recently, most schools adopting the program have offered the curriculum annually to two or more groups of faculty participants to create sufficient numbers of trained faculty to positively influence humanistic teaching at the institution.The authors discuss the program's learning theory, outline its curriculum, reflect on the program's accomplishments and plans for the future, and state how faculty trained in such programs could lead institutional initiatives and foster positive change in humanistic professional development at all levels of medical education.

  18. SYMPTOM PRESENTATIONS AND CLASSIFICATION OF AUTISM SPECTRUM DISORDER IN EARLY CHILDHOOD: APPLICATION TO THE DIAGNOSTIC CLASSIFICATION OF MENTAL HEALTH AND DEVELOPMENTAL DISORDERS OF INFANCY AND EARLY CHILDHOOD (DC:0-5).

    Science.gov (United States)

    Soto, Timothy; Giserman Kiss, Ivy; Carter, Alice S

    2016-09-01

    Over the past 5 years, a great deal of information about the early course of autism spectrum disorder (ASD) has emerged from longitudinal prospective studies of infants at high risk for developing ASD based on a previously diagnosed older sibling. The current article describes early ASD symptom presentations and outlines the rationale for defining a new disorder, Early Atypical Autism Spectrum Disorder (EA-ASD) to accompany ASD in the new revision of the ZERO TO THREE Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (DC:0-5) (in press) alternative diagnostic classification manual. EA-ASD is designed to identify children who are 9 to 36 months of age presenting with a minimum of (a) two social-communication symptoms and (b) one repetitive and restricted behavior symptom as well as (c) evidence of impairment, with the intention of providing these children with appropriately tailored services and improving the likelihood of optimizing their development. © 2016 Michigan Association for Infant Mental Health.

  19. EA 18G Growler Aircraft (EA 18G)

    Science.gov (United States)

    2015-12-01

    10051.9 N/A 13186.9 8636.4 11550.1 15672.4 1 APB Breach Confidence Level Confidence Level of cost estimate for current APB: 50% The current...estimate recommendation aims to provide sufficient resources to execute the program under normal conditions, encountering average levels of technical...TY $M) Initial PAUC Development Estimate Changes PAUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 93.573 4.150 1.442 -0.319 0.947 -0.348

  20. Deep-inelastic final states in a space-time description of shower development and hadronization

    International Nuclear Information System (INIS)

    Ellis, J.

    1996-06-01

    We extend a quantum kinetic approach to the description of hadronic showers in space, time and momentum space to deep-inelastic ep collisions, with particular reference to experiments at HERA. We follow the history of hard scattering events back to the initial hadronic state and forward to the formation of colour-singlet pre-hadronic clusters and their decays into hadrons. The time evolution of the space-like initial-state shower and the time-like secondary partons are treated similarly, and cluster formation is treated using a spatial criterion motivated by confinement and a non-perturbative model for hadronization. We calculate the time evolution of particle distributions in rapidity, transverse and longitudinal space. We also compare the transverse hadronic energy flow and the distribution of observed hadronic masses with experimental data from HERA, finding encouraging results, and discuss the background to large-rapidity-gap events. The techniques developed in this paper may be applied in the future to more complicated processes such as eA, pp, pA and AA collisions. (orig.)

  1. Deep-inelastic final states in a space-time description of shower development and hadronization

    International Nuclear Information System (INIS)

    Ellis, J.; Geiger, K.; Kowalski, H.

    1996-01-01

    We extend a quantum kinetic approach to the description of hadronic showers in space, time, and momentum space to deep-inelastic ep collisions, with particular reference to experiments at DESY HERA. We follow the history of hard scattering events back to the initial hadronic state and forward to the formation of color-singlet prehadronic clusters and their decays into hadrons. The time evolution of the spacelike initial-state shower and the timelike secondary partons are treated similarly, and cluster formation is treated using a spatial criterion motivated by confinement and a nonperturbative model for hadronization. We calculate the time evolution of particle distributions in rapidity, transverse, and longitudinal space. We also compare the transverse hadronic energy flow and the distribution of observed hadronic masses with experimental data from HERA, finding encouraging results, and discuss the background to large-rapidity-gap events. The techniques developed in this paper may be applied in the future to more complicated processes such as eA, pp, pA, and AA collisions. copyright 1996 The American Physical Society

  2. The Development of Case Studies as a Method within a Longitudinal Study of Special Educational Needs Provision in the Republic of Ireland

    Science.gov (United States)

    Rose, Richard; Shevlin, Michael

    2016-01-01

    When developing case studies within a longitudinal study of special educational needs provision within the Republic of Ireland, the authors were conscious of the critiques of the use of this approach within educational research. The difficulties associated with generalisation, challenges of ensuring trustworthiness and the possibilities of…

  3. A Semiparametric Marginalized Model for Longitudinal Data with Informative Dropout

    Directory of Open Access Journals (Sweden)

    Mengling Liu

    2012-01-01

    Full Text Available We propose a marginalized joint-modeling approach for marginal inference on the association between longitudinal responses and covariates when longitudinal measurements are subject to informative dropouts. The proposed model is motivated by the idea of linking longitudinal responses and dropout times by latent variables while focusing on marginal inferences. We develop a simple inference procedure based on a series of estimating equations, and the resulting estimators are consistent and asymptotically normal with a sandwich-type covariance matrix ready to be estimated by the usual plug-in rule. The performance of our approach is evaluated through simulations and illustrated with a renal disease data application.

  4. Technology, Learning, and the Classroom: Longitudinal Evaluation of a Faculty Development Model

    Science.gov (United States)

    Kaminski, Karen; Bolliger, Doris

    2012-01-01

    Technology, Learning, and the Classroom, a workshop designed to jump-start faculty's use of instructional technology in face-to-face classrooms, was offered as a week-long intensive workshop and once-a-week session over a semester. Faculty were interviewed five years after participation to determine the longitudinal effects, differences in opinion…

  5. Longitudinal changes in white matter microstructure after heavy cannabis use

    Directory of Open Access Journals (Sweden)

    Mary P. Becker

    2015-12-01

    Full Text Available Diffusion tensor imaging (DTI studies of cannabis users report alterations in brain white matter microstructure, primarily based on cross-sectional research, and etiology of the alterations remains unclear. We report findings from longitudinal voxelwise analyses of DTI data collected at baseline and at a 2-year follow-up on 23 young adult (18–20 years old at baseline regular cannabis users and 23 age-, sex-, and IQ-matched non-using controls with limited substance use histories. Onset of cannabis use was prior to age 17. Cannabis users displayed reduced longitudinal growth in fractional anisotropy in the central and parietal regions of the right and left superior longitudinal fasciculus, in white matter adjacent to the left superior frontal gyrus, in the left corticospinal tract, and in the right anterior thalamic radiation lateral to the genu of the corpus callosum, along with less longitudinal reduction of radial diffusion in the right central/posterior superior longitudinal fasciculus, corticospinal tract, and posterior cingulum. Greater amounts of cannabis use were correlated with reduced longitudinal growth in FA as was relatively impaired performance on a measure of verbal learning. These findings suggest that continued heavy cannabis use during adolescence and young adulthood alters ongoing development of white matter microstructure, contributing to functional impairment.

  6. Longitudinal MRI evaluation of intracranial development and vascular characteristics of breast cancer brain metastases in a mouse model.

    Directory of Open Access Journals (Sweden)

    Heling Zhou

    Full Text Available Longitudinal MRI was applied to monitor intracranial initiation and development of brain metastases and assess tumor vascular volume and permeability in a mouse model of breast cancer brain metastases. Using a 9.4T system, high resolution anatomic MRI and dynamic susceptibility contrast (DSC perfusion MRI were acquired at different time points after an intracardiac injection of brain-tropic breast cancer MDA-MB231BR-EGFP cells. Three weeks post injection, multifocal brain metastases were first observed with hyperintensity on T2-weighted images, but isointensity on T1-weighted post contrast images, indicating that blood-tumor-barrier (BTB at early stage of brain metastases was impermeable. Follow-up MRI revealed intracranial tumor growth and increased number of metastases that distributed throughout the whole brain. At the last scan on week 5, T1-weighted post contrast images detected BTB disruption in 160 (34% of a total of 464 brain metastases. Enhancement in some of the metastases was only seen in partial regions of the tumor, suggesting intratumoral heterogeneity of BTB disruption. DSC MRI measurements of relative cerebral blood volume (rCBV showed that rCBV of brain metastases was significantly lower (mean= 0.89±0.03 than that of contralateral normal brain (mean= 1.00±0.03; p<0.005. Intriguingly, longitudinal measurements revealed that rCBV of individual metastases at early stage was similar to, but became significantly lower than that of contralateral normal brain with tumor growth (p<0.05. The rCBV data were concordant with histological analysis of microvascular density (MVD. Moreover, comprehensive analysis suggested no significant correlation among tumor size, rCBV and BTB permeability. In conclusion, longitudinal MRI provides non-invasive in vivo assessments of spatial and temporal development of brain metastases and their vascular volume and permeability. The characteristic rCBV of brain metastases may have a diagnostic value.

  7. Políticas Públicas de Educação no Brasil: A Utilização da EaD Como Instrumento de Inclusão Social

    Directory of Open Access Journals (Sweden)

    José Matias Pereira

    2010-08-01

    Full Text Available The present article searchs to analyze - from the debate on the theory and the concept of education in the distance - the possibilities of intensive use of the EaD, in the context of the new public politics of education, as instrument of social inclusion in Brazil. It is verified, in this analysis that education in the distance, in a context where the continued learning started to be part in the life of the people, is presented as an important tool in the process of construction of public politics of education in the country. We conclude that, in the management of the public politics of education in the distance in Brazil must be advanced in the consistent construction of one arcabouço institucional and in the generation of stimulatons to the research in EaD, with sight to contribute for an increasing social inclusion in the country.

  8. Intelligent control for braking-induced longitudinal vibration responses of floating-type railway bridges

    Science.gov (United States)

    Qu, Wei-Lian; Qin, Shun-Quan; Tu, Jian-Weia; Liu, Jia; Zhou, Qiang; Cheng, Haibin; Pi, Yong-Lin

    2009-12-01

    This paper presents an intelligent control method and its engineering application in the control of braking-induced longitudinal vibration of floating-type railway bridges. Equations of motion for the controlled floating-type railway bridges have been established based on the analysis of the longitudinal vibration responses of floating-type railway bridges to train braking and axle-loads of moving trains. For engineering applications of the developed theory, a full-scale 500 kN smart magnetorheologic (MR) damper has been designed, fabricated and used to carry out experiments on the intelligent control of braking-induced longitudinal vibration. The procedure for using the developed intelligent method in conjunction with the full-scale 500 kN MR dampers has been proposed and used to control the longitudinal vibration responses of the deck of floating-type railway bridges induced by train braking and axle-loads of moving trains. This procedure has been applied to the longitudinal vibration control of the Tian Xingzhou highway and railway cable-stayed bridge over the Yangtze River in China. The simulated results have shown that the intelligent control system using the smart MR dampers can effectively control the longitudinal response of the floating-type railway bridge under excitations of braking and axle-loads of moving trains.

  9. Intelligent control for braking-induced longitudinal vibration responses of floating-type railway bridges

    International Nuclear Information System (INIS)

    Qu, Wei-Lian; Tu, Jian-Weia; Liu, Jia; Zhou, Qiang; Qin, Shun-Quan; Cheng, Haibin; Pi, Yong-Lin

    2009-01-01

    This paper presents an intelligent control method and its engineering application in the control of braking-induced longitudinal vibration of floating-type railway bridges. Equations of motion for the controlled floating-type railway bridges have been established based on the analysis of the longitudinal vibration responses of floating-type railway bridges to train braking and axle-loads of moving trains. For engineering applications of the developed theory, a full-scale 500 kN smart magnetorheologic (MR) damper has been designed, fabricated and used to carry out experiments on the intelligent control of braking-induced longitudinal vibration. The procedure for using the developed intelligent method in conjunction with the full-scale 500 kN MR dampers has been proposed and used to control the longitudinal vibration responses of the deck of floating-type railway bridges induced by train braking and axle-loads of moving trains. This procedure has been applied to the longitudinal vibration control of the Tian Xingzhou highway and railway cable-stayed bridge over the Yangtze River in China. The simulated results have shown that the intelligent control system using the smart MR dampers can effectively control the longitudinal response of the floating-type railway bridge under excitations of braking and axle-loads of moving trains

  10. A Short-Term Longitudinal Study of Memorial Development during Early Grade School.

    Science.gov (United States)

    Kunzinger, Edward L., III

    1985-01-01

    Overt rehearsal and free recall performance was analyzed longitudinally in two experimental testing sessions at 7 and later at 9 years of age. Measures of short- and long-term memory recall, and two measures of input processing were obtained. Significant increases between age levels were exhibited by all variables except short-term memory.…

  11. The recruitment of patients to trials in head and neck cancer: a qualitative study of the EaStER trial of treatments for early laryngeal cancer.

    Science.gov (United States)

    Hamilton, D W; de Salis, I; Donovan, J L; Birchall, M

    2013-08-01

    We aimed to investigate the factors contributing to poor recruitment to the EaStER trial "Early Stage glottic cancer: Endoscopic excision or Radiotherapy" feasibility study. We performed a prospective qualitative assessment of the EaStER trial at three centres to investigate barriers to recruitment and implement changes. Methods used included semi-structured interviews, focus groups and audio-recordings of recruitment encounters. First, surgeons and recruiters did not all accept the primary outcome as the rationale for the trial. Surgeons did not always adhere to the trial eligibility criteria leading to variations between centres in the numbers of "eligible" patients. Second, as both treatments were considered equally successful, recruiters and patients focused on the pragmatics of the different trial arms, favouring surgery over radiotherapy. The lack of equipoise was reflected in the way recruiters presented trial information. Third, patient views, beliefs and preferences were not fully elicited or addressed by recruiters. Fourth, in some centres, logistical issues made trial participation difficult. This qualitative research identified several major issues that explained recruitment difficulties. While there was insufficient time to address these in the EaStER trial, several factors would need to be addressed to launch further RCTs in head and neck cancer. These include the need for clear ongoing agreement among recruiting clinicians regarding details in the study protocol; an understanding of the logistical issues hindering recruitment at individual centres; and training recruiters to enable them to explain the need for randomisation and the rationale for the RCT to patients.

  12. Two-proton correlation functions for equilibrium and non-equilibrium emission

    International Nuclear Information System (INIS)

    Gong, W.G.; Gelbke, C.K.; Carlin, N.; De Souza, R.T.; Kim, Y.D.; Lynch, W.G.; Murakami, T.; Poggi, G.; Sanderson, D.; Tsang, M.B.; Xu, H.M.; Michigan State Univ., East Lansing; Fields, D.E.; Kwiatkowski, K.; Planeta, R.; Viola, V.E. Jr.; Yennello, S.J.; Indiana Univ., Bloomington; Indiana Univ., Bloomington; Pratt, S.

    1990-01-01

    Two-proton correlation functions are compared for equilibrium and non-equilibrium emission processes investigated, respectively, in ''reverse kinematics'' for the reactions 129 Xe+ 27 Al and 129 Xe+ 122 Sn at E/A=31 MeV and in ''forward kinematics'' for the reaction 14 N+ 197 Au at E/A=75 MeV. Observed differences in the shapes of the correlation functions are understood in terms of the different time scales for equilibrium and preequilibrium emission. Transverse and longitudinal correlation functions are very similar. (orig.)

  13. Development of an Engineering Soil Database

    Science.gov (United States)

    2017-12-27

    ER D C TR 1 7- 15 Rapid Airfield Damage Recovery (RADR) Program Development of an Engineering Soil Database En gi ne er R es ea rc...distribution is unlimited. The US Army Engineer Research and Development Center (ERDC) solves the nation’s toughest engineering and environmental...challenges. ERDC develops innovative solutions in civil and military engineering , geospatial sciences, water resources, and environmental sciences

  14. Nonlinear Cascade Strategy for Longitudinal Control of Electric Vehicle.

    Science.gov (United States)

    El Majdoub, K; Giri, F; Ouadi, H; Chaoui, F Z

    2014-01-01

    The problem of controlling the longitudinal motion of front-wheels electric vehicle (EV) is considered making the focus on the case where a single dc motor is used for both front wheels. Chassis dynamics are modelled applying relevant fundamental laws taking into account the aerodynamic effects and the road slope variation. The longitudinal slip, resulting from tire deformation, is captured through Kiencke's model. Despite its highly nonlinear nature the complete model proves to be utilizable in longitudinal control design. The control objective is to achieve a satisfactory vehicle speed regulation in acceleration/deceleration stages, despite wind speed and other parameters uncertainty. An adaptive controller is developed using the backstepping design technique. The obtained adaptive controller is shown to meet its objectives in presence of the changing aerodynamics efforts and road slope.

  15. Time-dependent efficacy of longitudinal biomarker for clinical endpoint.

    Science.gov (United States)

    Kolamunnage-Dona, Ruwanthi; Williamson, Paula R

    2018-06-01

    Joint modelling of longitudinal biomarker and event-time processes has gained its popularity in recent years as they yield more accurate and precise estimates. Considering this modelling framework, a new methodology for evaluating the time-dependent efficacy of a longitudinal biomarker for clinical endpoint is proposed in this article. In particular, the proposed model assesses how well longitudinally repeated measurements of a biomarker over various time periods (0,t) distinguish between individuals who developed the disease by time t and individuals who remain disease-free beyond time t. The receiver operating characteristic curve is used to provide the corresponding efficacy summaries at various t based on the association between longitudinal biomarker trajectory and risk of clinical endpoint prior to each time point. The model also allows detecting the time period over which a biomarker should be monitored for its best discriminatory value. The proposed approach is evaluated through simulation and illustrated on the motivating dataset from a prospective observational study of biomarkers to diagnose the onset of sepsis.

  16. Longitudinal mediators of achievement in mathematics and reading in typical and atypical development.

    Science.gov (United States)

    Barnes, Marcia A; Raghubar, Kimberly P; English, Lianne; Williams, Jeffrey M; Taylor, Heather; Landry, Susan

    2014-03-01

    Longitudinal studies of neurodevelopmental disorders that are diagnosed at or before birth and are associated with specific learning difficulties at school-age provide one method for investigating developmental precursors of later-emerging academic disabilities. Spina bifida myelomeningocele (SBM) is a neurodevelopmental disorder associated with particular problems in mathematics, in contrast to well-developed word reading. Children with SBM (n=30) and typically developing children (n=35) were used to determine whether cognitive abilities measured at 36 and 60 months of age mediated the effect of group on mathematical and reading achievement outcomes at 8.5 and 9.5 years of age. A series of multiple mediator models showed that: visual-spatial working memory at 36 months and phonological awareness at 60 months partially mediated the effect of group on math calculations, phonological awareness partially mediated the effect of group on small addition and subtraction problems on a test of math fluency, and visual-spatial working memory mediated the effect of group on a test of math problem solving. Groups did not differ on word reading, and phonological awareness was the only mediator for reading fluency and reading comprehension. The findings are discussed with reference to theories of mathematical development and disability and with respect to both common and differing cognitive correlates of math and reading. Copyright © 2013 Elsevier Inc. All rights reserved.

  17. Longitudinal muscle of the esophagus: its role in esophageal health and disease.

    Science.gov (United States)

    Mittal, Ravinder K

    2013-07-01

    The muscularis propria of the esophagus is organized into circular and longitudinal muscle layers. The function of the longitudinal muscle and its role in bolus propulsion are not clear. The goal of this review is to summarize what is known of the role of the longitudinal muscle in health, as well as in sensory and motor disorders of the esophagus. Simultaneous manometry and ultrasound imaging reveal that, during peristalsis, the two muscle layers of the esophagus contract in perfect synchrony. On the contrary, during transient lower esophageal sphincter (LES) relaxation, longitudinal muscle contracts independent of the circular muscle. Recent studies have provided novel insights into the role of the longitudinal muscle in LES relaxation and descending relaxation of the esophagus. In certain diseases (e.g. some motility disorders of the esophagus), there is discoordination between the two muscle layers, which likely plays an important role in the genesis of dysphagia and delayed esophageal emptying. There is close temporal correlation between prolonged contractions of the longitudinal muscles of the esophagus and esophageal 'angina-like' pain. Novel techniques to record longitudinal muscle contraction are reviewed. Longitudinal muscles of the esophagus play a key role in the physiology and pathophysiology of esophageal sensory and motor function. Neuro-pharmacologic controls of circular and longitudinal muscle are different, which provides an opportunity for the development of novel pharmacological therapies in the treatment of esophageal sensory and motor disorders.

  18. The longitudinal effects of physical activity and dietary calcium on bone mass accrual across stages of pubertal development.

    Science.gov (United States)

    Lappe, Joan M; Watson, Patrice; Gilsanz, Vicente; Hangartner, Thomas; Kalkwarf, Heidi J; Oberfield, Sharon; Shepherd, John; Winer, Karen K; Zemel, Babette

    2015-01-01

    Childhood and adolescence are critical periods of bone mineral content (BMC) accrual that may have long-term consequences for osteoporosis in adulthood. Adequate dietary calcium intake and weight-bearing physical activity are important for maximizing BMC accrual. However, the relative effects of physical activity and dietary calcium on BMC accrual throughout the continuum of pubertal development in childhood remains unclear. The purpose of this study was to determine the effects of self-reported dietary calcium intake and weight-bearing physical activity on bone mass accrual across the five stages of pubertal development in a large, diverse cohort of US children and adolescents. The Bone Mineral Density in Childhood study was a mixed longitudinal study with 7393 observations on 1743 subjects. Annually, we measured BMC by dual-energy X-ray absorptiometry (DXA), physical activity and calcium intake by questionnaire, and pubertal development (Tanner stage) by examination for up to 7 years. Mixed-effects regression models were used to assess physical activity and calcium intake effects on BMC accrual at each Tanner stage. We found that self-reported weight-bearing physical activity contributed to significantly greater BMC accrual in both sexes and racial subgroups (black and nonblack). In nonblack males, the magnitude of the activity effect on total body BMC accrual varied among Tanner stages after adjustment for calcium intake; the greatest difference between high- and low-activity boys was in Tanner stage 3. Calcium intake had a significant effect on bone accrual only in nonblack girls. This effect was not significantly different among Tanner stages. Our findings do not support differential effects of physical activity or calcium intake on bone mass accrual according to maturational stage. The study demonstrated significant longitudinal effects of weight-bearing physical activity on bone mass accrual through all stages of pubertal development. © 2014 American

  19. Political and social determinants of life expectancy in less developed countries: a longitudinal study

    Directory of Open Access Journals (Sweden)

    Lin Ro-Ting

    2012-01-01

    Full Text Available Abstract Background This study aimed to examine the longitudinal contributions of four political and socioeconomic factors to the increase in life expectancy in less developed countries (LDCs between 1970 and 2004. Methods We collected 35 years of annual data for 119 LDCs on life expectancy at birth and on four key socioeconomic indicators: economy, measured by log10 gross domestic product per capita at purchasing power parity; educational environment, measured by the literacy rate of the adult population aged 15 years and over; nutritional status, measured by the proportion of undernourished people in the population; and political regime, measured by the regime score from the Polity IV database. Using linear mixed models, we analyzed the longitudinal effects of these multiple factors on life expectancy at birth with a lag of 0-10 years, adjusting for both time and regional correlations. Results The LDCs' increases in life expectancy over time were associated with all four factors. Political regime had the least influence on increased life expectancy to begin with, but became significant starting in the 3rd year and continued to increase, while the impact of the other socioeconomic factors began strong but continually decreased over time. The combined effects of these four socioeconomic and political determinants contributed 54.74% - 98.16% of the life expectancy gains throughout the lag periods of 0-10 years. Conclusions Though the effect of democratic politics on increasing life expectancy was relatively small in the short term when compared to the effects of the other socioeconomic factors, the long-term impact of democracy should not be underestimated.

  20. [Specific language impairment and electroencephalogram: which recommendations in clinical practice? A cohort of 24 children].

    Science.gov (United States)

    Billard, C; Hassairi, I; Delteil, F

    2010-04-01

    Electroencephalographic recording (electroencephalogram [EEG]) is frequent in specific language impairment (SLI), whereas the relations between epileptiform activity (EA) and language disorders remain uncertain and the therapeutic approach undetermined. The aim of this prospective study was to clarify EEG indications and interpretation in SLI. We present a prospective study of cognitive (speech-language measures, psychological assessments) and electroencephalographic data on 24 children (20 males, 4 females; mean age: 4 years 5 months; range: 3 years to 4 years 8 months) with a diagnosis of SLI, defined as a pathologic score on at least 2 speech-language measures and IQ performance of at least 80 points, within epileptic seizures. All participants had an EEG after partial deprivation of sleep at night. When nonsporadic EA was found, 24-h EEG was performed. Antiepileptic treatment was prescribed depending on the frequency of discharges and the SLI profile. The follow-up lasted 2 years. All patients reached stage II sleep during their EEG. Seven children had abnormal electroencephalography results, including 5 children with EA. Two patients with mixed SLI prevailing on expression presented a left centrotemporal spike focus on EEG becoming subcontinuous during sleep. In the first case, the language progressed without antiepileptic treatment. The 2nd case was treated with ethosuximide; the EEG normalized on subsequent recordings, but the language disorder remained severe. The lexical and syntactic understanding and syntactic production scores were not different for children presented EA (5 cases) or without (19 cases) (Wilcoxon's test). Finally, the progression of the various linguistic skills was similar whether or not the children had EA (pactivity is more frequent in SLI than in normal children. It can be seen in all types of SLI but preferentially in the mixed forms. The longitudinal systematic evaluation of all the children with or without EA has never been

  1. Development and Validation of a HPLC-UV Method for the Evaluation of Ellagic Acid in Liquid Extracts of Eugenia uniflora L. (Myrtaceae Leaves and Its Ultrasound-Assisted Extraction Optimization

    Directory of Open Access Journals (Sweden)

    Paulo Isaac Dias Assunção

    2017-01-01

    Full Text Available A simple HPLC-UV method has been developed and validated for the quantification of ellagic acid (EA in ethanol extracts of Eugenia uniflora L. (Myrtaceae leaves. The ultrasound-assisted extraction (UAE optimization was performed using a Box Behnken design (33 combined with response surface methodology to study the effects of the ethanol concentration (%, w/w, extraction time (minutes, and temperature (°C on the EA concentration. The optimized results showed that the highest extraction yield of EA by UAE was 26.0 μg mL−1 when using 44% (w/w ethanol as the solvent, 22 minutes as the extraction time, and 59°C as the extraction temperature. The concentration of EA in relation to the predicted value was 93.7%  ±  0.4. UAE showed a strong potential for EA extraction.

  2. Development and Validation of a HPLC-UV Method for the Evaluation of Ellagic Acid in Liquid Extracts of Eugenia uniflora L. (Myrtaceae) Leaves and Its Ultrasound-Assisted Extraction Optimization.

    Science.gov (United States)

    Assunção, Paulo Isaac Dias; da Conceição, Edemilson Cardoso; Borges, Leonardo Luiz; de Paula, Joelma Abadia Marciano

    2017-01-01

    A simple HPLC-UV method has been developed and validated for the quantification of ellagic acid (EA) in ethanol extracts of Eugenia uniflora L. (Myrtaceae) leaves. The ultrasound-assisted extraction (UAE) optimization was performed using a Box Behnken design (3 3 ) combined with response surface methodology to study the effects of the ethanol concentration (%, w/w), extraction time (minutes), and temperature (°C) on the EA concentration. The optimized results showed that the highest extraction yield of EA by UAE was 26.0  μ g mL -1 when using 44% (w/w) ethanol as the solvent, 22 minutes as the extraction time, and 59°C as the extraction temperature. The concentration of EA in relation to the predicted value was 93.7%  ±  0.4. UAE showed a strong potential for EA extraction.

  3. A study of the HEB longitudinal dynamics

    International Nuclear Information System (INIS)

    Larson, D.J.

    1993-12-01

    A study of the High Energy Booster (HEB) longitudinal dynamics is presented. Full derivations of ramp dependent longitudinal variables are given. The formulas assume that the input magnetic field and beam longitudinal emittance are known as a function of time, and that either the rf voltage or the rf bucket area are known as a function of time. Once these three inputs are specified, the formulas can be used to calculate values for all other longitudinal dynamics variables. The formulas have been incorporated into a single computer code named ELVIRA: Evaluation of Longitudinal Variables in Relativistic Accelerators. The ELVIRA code is documented here in detail. The ELVIRA code is used under two initial longitudinal emittance assumptions to plot ramp functions for the longitudinal dynamics design of the HEB as of May 5, 1992

  4. Revised analysis of the (1+1) EA for the minimum spanning tree problem

    DEFF Research Database (Denmark)

    Witt, Carsten

    2014-01-01

    We revisit the classical analysis of the (1+1) EA for the minimum spanning tree problem in the case that nothing is known about the weights of the underlying graph. Here the original upper bound on the expected running time by Neumann and Wegener [Theor. Comput. Sci. 378(1), 32-40, 2007], which...... depends on the largest weight of the graph, is of no use. The best upper bound available before in this case is due to Reichel and Skutella [FOGA 2009, 21-28] and is of order O(m3 \\log n), where m is the number of edges and n the number of vertices. Using an adaptive drift analysis, we show the improved...... bound O(m2 (sqrt{c(G)} + \\log n)), where c(G) is the circumference (length of the longest cycle) of the graph. This is only by an asymptotic factor of at most sqrt{n}/\\log n away from the classical lower bound. Furthermore, an alternative fitness function leading to the bound O(m2\\log n) is proposed...

  5. Ellagic Acid: A Logical Lead for Drug Development?

    Science.gov (United States)

    Shakeri, Abolfazl; Zirak, Mohammad Reza; Sahebkar, Amirhossein

    2018-01-01

    Naturally occurring polyphenols are the subject of increasing attention due to their potent antioxidant activity and their marked effects on the prevention of various oxidative stress-associated diseases such as cancer. Ellagic acid (EA) is an herbal polyphenol that is structurally a condensed dimer of gallic acid. This review aims to provide a comprehensive and updated overview on the biological activities of EA and potential therapeutic applications. EA is found in fruits and nuts, either in the combined form with hexahydroxydiphenic acid or in the bound form (ellagitannins). EA exhibits many biological properties such as antioxidant, anti-diabetic, anticancer and apoptosis-inducing activities. These biological and pharmacological properties are relevant to the treatment of several human diseases. Owing to its multiple mechanisms of action, EA represents a potential therapeutic agent against human diseases particularly cancer. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. Substance Use as a Longitudinal Predictor of the Perpetration of Teen Dating Violence

    Science.gov (United States)

    Temple, Jeff R.; Shorey, Ryan C.; Fite, Paula; Stuart, Gregory L.; Le, Vi Donna

    2013-01-01

    The prevention of teen dating violence is a major public health priority. However, the dearth of longitudinal studies makes it difficult to develop programs that effectively target salient risk factors. Using a school-based sample of ethnically diverse adolescents, this longitudinal study examined whether substance use (alcohol, marijuana, and…

  7. Global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa based on atmospheric observations

    Science.gov (United States)

    Vollmer, M. K.; Miller, B. R.; Rigby, M. L.; Reimann, S.; Muhle, J.; Agage, Soge, Snu Members, Kopri Members

    2010-12-01

    We report on the atmospheric measurements and global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc (CH3CH2CF2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). These measurements are from in-situ observations at stations of AGAGE (Advanced Global Atmospheric Gases Experiment) and SOGE (System for Observations of Halogenated Greenhouse Gases in Europe), and from the Korean station Gosan. We also report on flask sample measurements from the Antarctic stations King Sejong and Troll, and extend our records back to the 1970s using archived air samples of both hemispheres. All data are used in a global 12-box 2-dimensional atmospheric transport model to derive global abundances and emission estimates. All four HFCs have strongly increased in the atmosphere in recent years with growth rates at nearly 10 %, resulting in dry air mole fractions at the end of 2009 of 0.49 ppt for HFC-365mfc, 1.00 ppt for HFC-245fa, and 0.51 ppt for HFC-227ea. HFC-236fa, for which we report the first atmospheric measurements, is less abundant and has grown to 0.069 ppt at the end of 2009. Our model results show rapidly growing emissions of HFC-365mfc and HFC-245fa after 2002 but surprisingly these have now started to decline to globally 2.7 kt/yr (HFC-365mfc) and 6.1 kt/yr (HFC-245fa). On the other hand HFC-227ea and HFC-236fa show uninterrupted growth in their emissions of 2.5 kt/yr and 0.2 kt/yr at the end of 2009.

  8. [Early Intervention and Cognitive Development: A Longitudinal Study with Psychologically Stressed Mother-Child-Dyad during Early Childhood].

    Science.gov (United States)

    Zwönitzer, Annabel; Ziegenhain, Ute; Bovenschen, Ina; Pillhofer, Melanie; Spangler, Gottfried; Gerlach, Jennifer; Gabler, Sandra; Kindler, Heinz; Fegert, Jörg M; Künster, Anne Katrin

    2016-01-01

    Early intervention programs aiming at developing parents’ relationship and parenting skills and supporting young families have become increasingly established in Germany throughout the last decade. The present longitudinal study analyzed 53 children and their mothers receiving early intervention due to their psychosocially highly challenging life situations and personal circumstances. The children were examined at birth and at an age of twelve months as well as between ages two and four. The results revealed that the child’s cognitive development could be predicted by both maternal sensitivity and mother’s psychosocial stress. However, the amount, type, and intensity of early intervention did not have any effect on the child’s development. In terms of the effectiveness of early interventions the results implicate that interventions seems to be offered in an unspecific manner and does not contribute to an improvement of the child’s developmental status.

  9. Multiple Kernel Learning with Random Effects for Predicting Longitudinal Outcomes and Data Integration

    Science.gov (United States)

    Chen, Tianle; Zeng, Donglin

    2015-01-01

    Summary Predicting disease risk and progression is one of the main goals in many clinical research studies. Cohort studies on the natural history and etiology of chronic diseases span years and data are collected at multiple visits. Although kernel-based statistical learning methods are proven to be powerful for a wide range of disease prediction problems, these methods are only well studied for independent data but not for longitudinal data. It is thus important to develop time-sensitive prediction rules that make use of the longitudinal nature of the data. In this paper, we develop a novel statistical learning method for longitudinal data by introducing subject-specific short-term and long-term latent effects through a designed kernel to account for within-subject correlation of longitudinal measurements. Since the presence of multiple sources of data is increasingly common, we embed our method in a multiple kernel learning framework and propose a regularized multiple kernel statistical learning with random effects to construct effective nonparametric prediction rules. Our method allows easy integration of various heterogeneous data sources and takes advantage of correlation among longitudinal measures to increase prediction power. We use different kernels for each data source taking advantage of the distinctive feature of each data modality, and then optimally combine data across modalities. We apply the developed methods to two large epidemiological studies, one on Huntington's disease and the other on Alzheimer's Disease (Alzheimer's Disease Neuroimaging Initiative, ADNI) where we explore a unique opportunity to combine imaging and genetic data to study prediction of mild cognitive impairment, and show a substantial gain in performance while accounting for the longitudinal aspect of the data. PMID:26177419

  10. Participation in the special supplemental nutrition program for women, infants, and children is not associated with early childhood socioemotional development: Results from a longitudinal cohort study

    Directory of Open Access Journals (Sweden)

    Abigail Arons, MPAff

    2016-12-01

    Full Text Available Socioemotional development in early childhood has long-term impacts on health status and social outcomes, and racial and socioeconomic disparities in socioemotional skills emerge early in life. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC is an early childhood nutrition intervention with the potential to ameliorate these disparities. Our objective was to assess the impact of WIC on early socioemotional development in a longitudinal study. We examined the association between WIC participation and scores on the Brief Infant Toddler Social Emotional Assessment (BITSEA in 327 predominantly African American mother–child dyads who were participants in the longitudinal Conditions Affecting Neurocognitive Development in Early Life (CANDLE Study (Memphis, TN. To account for selection bias, we used within-child fixed effects to model the variability in each child's BITSEA scores over two measurement occasions (ages 12 and 24 months. Final models were adjusted for time-varying characteristics including child age, maternal stress, mental health, child abuse potential, marital status, and food stamp participation. In fully adjusted models, we found no statistically significant effect of WIC on change in socioemotional development (β = 0.22 [SD = 0.39] and β = −0.58 [SD = 0.79] for BITSEA Competence and Problem subdomains, respectively. Using rigorous methods and a longitudinal study design, we found no significant association between WIC and socioemotional development in a high needs population. This finding suggests that early childhood interventions that more specifically target socioemotional development are necessary if we are to reduce racial disparities in socioemotional skills and prevent poor social and health outcomes across the life course.

  11. Mybs in mouse hair follicle development

    Czech Academy of Sciences Publication Activity Database

    Veselá, Barbora; Švandová, Eva; Šmarda, J.; Matalová, Eva

    2014-01-01

    Roč. 46, č. 5 (2014), s. 352-355 ISSN 0040-8166 R&D Projects: GA ČR GCP302/12/J059 Institutional support: RVO:67985904 Keywords : hair follicle * stem cells * c-Myb * B-Myb * development Subject RIV: EA - Cell Biology Impact factor: 1.252, year: 2014

  12. A Longitudinal Study on Mathematics Teaching Efficacy: Which Factors (Un)Support the Development?

    Science.gov (United States)

    Isiksal-Bostan, Mine

    2016-01-01

    The aim of this longitudinal study was to examine prospective teachers' mathematics teaching efficacy belief during their enrollment in teacher education program and at the end of their first year of teaching. In addition, the factors that enhance or inhibit participants' efficacy belief and how these factors affect their mathematics teaching…

  13. Longitudinal myelitis associated with yellow fever vaccination.

    Science.gov (United States)

    Chaves, M; Riccio, P; Patrucco, L; Rojas, J I; Cristiano, E

    2009-07-01

    Severe adverse reaction to yellow fever (YF) vaccine includes the yellow fever vaccine-associated neurotropic disease. This terminology includes postvaccinal encephalitis, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. The objective of this communication is to report a patient who received a YF vaccine in Argentina and subsequently developed longitudinal myelitis with a symptom that had previously gone unreported in the literature. A 56-year-old man began with progressive paraparesia, urinary retention, and constipation 48 h previous to admission. The patient received YF vaccine 45 days prior to the onset of the symptoms. There was no history of other immunization or relevant condition. MR of the spine showed longitudinal intramedullary hyperintense signal (D5-12) without gadolinium enhancement. A high concentration of YFV-specific IgM vaccine antibody was found in the cerebrospinal fluid (CSF). Serological tests for other flavivirus were negative. A diagnosis of longitudinal myelitis without encephalitis associated with YF vaccine was performed and symptoms improved 5 days later. This is the first report dealing with longitudinal myelitis as a serious adverse event associated with YF vaccination in which confirmation of the presence of antibodies in CSF was found. To date, it is also the first report with serological confirmation in Argentina and in South America. We consider that the present investigation will raise awareness in the region in the reporting of adverse events related to YF vaccine and improve our knowledge of adverse reactions to the vaccine.

  14. Development of left ventricular longitudinal speckle tracking echocardiography in very low birth weight infants with and without bronchopulmonary dysplasia during the neonatal period.

    Directory of Open Access Journals (Sweden)

    Christoph Czernik

    Full Text Available OBJECTIVES: In preterm infants, postnatal myocardial adaptation may be complicated by bronchopulmonary dysplasia (BPD. We aimed to describe the development of left ventricular function by serial 2D, Doppler, and speckle tracking echocardiography (2D-STE in infants with and without BPD during the neonatal period and compare these to anthropometric and conventional hemodynamic parameters. STUDY DESIGN: Prospective echocardiography on day of life (DOL 1, 7, 14, and 28 in 119 preterm infants 10% were seen for the apical segment. While anthropometric parameters show rapid development during the first 4 weeks of life, the speckle tracking parameters did not differ statistically significantly during the neonatal period. Infants with and without BPD differed significantly (p<0.001 in the development of anthropometric parameters, conventional hemodynamic parameters except for heart rate, and 2D-STE parameters: global longitudinal systolic strain rate (GLSSR and longitudinal systolic strain for the mid left wall (LSSR. The largest differences were seen at DOL 1 and 7 in GLSSR (p<0.001 and in LSSR (p<0.01. CONCLUSIONS: Reproducible 2D-STE measurements are possible in preterm infants <1500 g. Cardiac deformation reveals early (DOL 1 and 7 ventricular changes (GLSSR and LSSR in very low birth weight infants who develop BPD.

  15. The development of multitasking in children aged 7-12years: Evidence from cross-sectional and longitudinal data.

    Science.gov (United States)

    Yang, Tian-Xiao; Xie, Weizhen; Chen, Chu-Sheng; Altgassen, Mareike; Wang, Ya; Cheung, Eric F C; Chan, Raymond C K

    2017-09-01

    This study investigated the development of multitasking ability across childhood. A sample of 65 typically developing children aged 7, 9, and 11years completed two multitasking tests across three time points within a year. Cross-sectional and longitudinal data consistently indicated continuous linear growth in children's multitasking ability. By the age of 12years, children could effectively perform a simple multitasking scenario comprising six equally important tasks, although their ability to strategically organize assorted tasks with varied values and priorities in a complex multitasking setting had not reached proficiency yet. Cognitive functions underlying a complex multitasking scenario varied in their developmental trajectories. Retrospective memory developed continuously from 7 to 12years of age, suggesting its supporting role in the development of multitasking. Planning skills developed slowly and showed practice effects for older children but not for younger children. The ability to adhere to plans also developed slowly, and children of all age groups benefited from practice. This study offers a preliminary benchmark for future comparison with clinical populations and may help to inform the development of targeted interventions. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. On Longitudinal Spectral Coherence

    DEFF Research Database (Denmark)

    Kristensen, Leif

    1979-01-01

    It is demonstrated that the longitudinal spectral coherence differs significantly from the transversal spectral coherence in its dependence on displacement and frequency. An expression for the longitudinal coherence is derived and it is shown how the scale of turbulence, the displacement between ...... observation sites and the turbulence intensity influence the results. The limitations of the theory are discussed....

  17. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.

    Science.gov (United States)

    Subbarao, Padmaja; Anand, Sonia S; Becker, Allan B; Befus, A Dean; Brauer, Michael; Brook, Jeffrey R; Denburg, Judah A; HayGlass, Kent T; Kobor, Michael S; Kollmann, Tobias R; Kozyrskyj, Anita L; Lou, W Y Wendy; Mandhane, Piushkumar J; Miller, Gregory E; Moraes, Theo J; Pare, Peter D; Scott, James A; Takaro, Tim K; Turvey, Stuart E; Duncan, Joanne M; Lefebvre, Diana L; Sears, Malcolm R

    2015-10-01

    The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  18. Heat partition in the E/A=8.5 MeV 74Ge+165Ho reaction

    International Nuclear Information System (INIS)

    Kwiatkowski, K.; Planeta, R.; Zhou, S.H.; Viola, V.E.; Breuer, H.; McMahan, M.A.; Mignerey, A.C.

    1990-01-01

    The excitation-energy distribution of projectilelike fragments formed in the E/A=8.5 MeV 74 Ge+ 165 Ho reaction has been obtained by applying a statistical evaporation calculation to the difference between primary fragment mass yields derived from kinematic coincidence measurements and directly measured yields. A gradual transition from approximate equipartition of excitation energy for small energy losses to a division that favors the targetlike fragment for highly damped events is observed, in agreement with previous measurements. For a given energy loss, heat partition is found to correlate with the direction of net nucleon transfer. The variances of the excitation-energy distributions are shown to increase monotonically as a function of energy loss. The average data are compared with predictions of the nucleon exchange transport model. The results suggest that energy-loss mechanisms in addition to nucleon exchange may be important in the early stages of the collision

  19. Assessment of left ventricular deformation in patients with Ebstein’s anomaly by cardiac magnetic resonance tissue tracking

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xi; Zhang, Qin [Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Yang, Zhi-gang, E-mail: yangzg666@163.com [Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Shi, Ke; Xu, Hua-yan [Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Xie, Lin-jun [Department of Radiology, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, Sichuan 610041 (China); Jiang, Li; Diao, Kai-yue [Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041 (China); Guo, Ying-kun [Department of Radiology, West China Second University Hospital, Sichuan University, 20# Section 3 South Renmin Road, Chengdu, Sichuan 610041 (China)

    2017-04-15

    Purpose: The aim of this study was to clarify the feasibility of myocardial strain using cardiovascular magnetic resonance (CMR) for the evaluation of left ventricular (LV) deformation in patients with Ebstein’s anomaly (EA). Materials and methods: We recruited 32 patients with EA and 30 controls for CMR examination and measured LV function, dimension and tissue tracking parameters (the global and regional radial, circumferential and longitudinal peak strain), together with the right ventricle (RV) dimension. LV strain parameters were compared among the controls, patients with preserved LV ejection fraction (LVEF; ≥55%), and patients with reduced LVEF (<55%). Pearson’s correlation was used to evaluate relationships between tissue tracking parameters with the RVEDD/LVEDD index and LVEF. An ROC analysis was also performed to determine whether the cut-off values for PS could be used to differentiate LV dysfunction between patients with EA and controls. The intraclass correlation coefficient (ICC) was used to assess the inter- and intra-observer variability. Results: The global strain parameters all decreased significantly in the EA group compared with the control group (all P < 0.05). Furthermore, the global radial and circumferential peak strain (PS) were obviously even lower in the reduced LVEF group than the strain measured in preserved LVEF groups (28.64% vs. 37.39%, p < 0.05; and −8.20% vs. −17.89%; p < 0.05; respectively). The regional strain abnormalities in EA patients were mainly involved in basal and middle segments. The results also demonstrated a significant correlation between the ratio of the RV end-diastolic dimension to the LV end-diastolic dimension (RVEDD/LVEDD index) with the global circumferential PS (r = 0.508) and the longitudinal PS (r = 0.474), as well as a good correlation between radial PS and LVEF (r = 0.465). The ICCs for intra- and inter-observer variability were 0.797–0.904 and 0.701–0.896. Conclusions: LV strain serves an

  20. Longitudinal Research with Latent Variables

    CERN Document Server

    van Montfort, Kees; Satorra, Albert

    2010-01-01

    This book combines longitudinal research and latent variable research, i.e. it explains how longitudinal studies with objectives formulated in terms of latent variables should be carried out, with an emphasis on detailing how the methods are applied. Because longitudinal research with latent variables currently utilizes different approaches with different histories, different types of research questions, and different computer programs to perform the analysis, the book is divided into nine chapters. Starting from some background information about the specific approach, short history and the ma

  1. Hadronic cosmic ray interactions near the LHC energy region and in the UHE domain of giant EAS

    Energy Technology Data Exchange (ETDEWEB)

    Capdevielle, J.N. [AstroParticule et Cosmologie (APC), College de France, 75 - Paris (France)

    2005-07-01

    The fluctuations of ray families simulated with CORSIKA in the energy region 3.10{sup 15} - 10{sup 17} eV on the basis of standard Lns collider physics exhibits alignments of secondaries in the stratosphere and at ground level. The remarkable event recorded on the Concorde does not fit well however those cases. The possible hints of new mechanisms, especially the valence diquark breaking, are considered. Observing that the extrapolation of the original cosmic ray primary spectrum derived from the size spectrum measured in the Akeno classical EAS array coincides with the spectrum measured recently by the Hires Stereo experiment, we point out a possible overestimation of the primary energy in inclined showers of the surface arrays like AGASA. (author)

  2. Which emotional regulatory strategy makes Chinese adolescents happier? A longitudinal study

    NARCIS (Netherlands)

    Sang, B.; Deng, X.; Luan, Z.

    2014-01-01

    Growing interest in emotion regulation is reflected in the studies of cognitive and social development. However, the extant studies mainly highlight how emotion regulation develops based on a western value system. This study utilised a longitudinal design to examine the development of emotion

  3. Theory and simulations of radiation friction induced enhancement of laser-driven longitudinal fields

    Science.gov (United States)

    Gelfer, E. G.; Fedotov, A. M.; Weber, S.

    2018-06-01

    We consider the generation of a quasistatic longitudinal electric field by intense laser pulses propagating in a transparent plasma with radiation friction (RF) taken into account. For both circular and linear polarization of the driving pulse we develop a 1D analytical model of the process, which is valid in a wide range of laser and plasma parameters. We define the parameter region where RF results in an essential enhancement of the longitudinal field. The amplitude and the period of the generated longitudinal wave are estimated and optimized. Our theoretical predictions are confirmed by 1D and 2D PIC simulations. We also demonstrate numerically that RF should substantially enhance the longitudinal field generated in a plasma by a 10 PW laser such as ELI Beamlines.

  4. Evidence that morphine and opioid peptides do not share a common pathway with adenosine in inhibiting acetylcholine release from isolated intestine.

    Science.gov (United States)

    Vizi, E S; Somogyi, G T; Magyar, K

    1981-12-01

    1 The release of acetylcholine from guinea-pig ileal isolated longitudinal muscle strip with intact Auerbach's plexus was measured by bioassay and by a radioisotope technique. 2 Normorphine (5 x 10(-7)M) and D-Met2, Pro5-enkephalinamide (D-Met, Pro-EA) reduced the release of acetylcholine. Theophylline, an adenosine antagonist, failed to prevent the inhibitory effect of normorphine or D-Met, Pro-EA. 3 Theophylline (1.7 x 10(-4)M) by itself enhanced the twitch responses to field stimulation (0.1 Hz) but did not prevent the inhibitory effect of normorphine and D-Met, Pro-EA. 4 From the results it can be concluded that morphine and opioid peptides do not share a common pathway with adenosine in inhibiting acetylcholine release from axon terminals of Auerbach's plexus.

  5. Longitudinal joint specifications and performance.

    Science.gov (United States)

    2012-08-01

    Deterioration of longitudinal joints is widely recognized as one of the major factors contributing to failure of asphalt pavements. Finding : ways to improve the durability of longitudinal joints will lead to improved service lives and lower life cyc...

  6. Photometric solution and frequency analysis of the oEA system EW Boo

    International Nuclear Information System (INIS)

    Zhang, X. B.; Wang, K.; Luo, Y. P.

    2015-01-01

    We present the first photometric solution and frequency analysis of the neglected oscillating Algol-type (oEA) binary EW Boo. B- and V-band light curves of the star were obtained on 11 nights in 2014. Using the Wilson–Devinney code, the eclipsing light curves were synthesized and the first photometric solution was derived for the binary system. The results reveal that EW Boo could be a semi-detached system with the less-massive secondary component filling its Roche lobe. By subtracting the eclipsing light changes from the data, we obtained the intrinsic pulsating light curves of the hotter, massive primary component. Frequency analysis of residual light shows multi-mode pulsation with the dominant period at 0.01909 days. A preliminary mode identification suggests that the star could be pulsating in non-radial (l = 1) modes. The long-term orbital period variation of the system was also investigated for the first time. An improved orbital period and new ephemerides of the eclipsing binary are given. The O−C analysis indicates a secular period increasing at a rate of dP/dt=2.9×10 −7 days yr −1 , which could be interpreted as mass transfer from the cooler secondary to the primary component.

  7. Comparative Study on Theoretical and Machine Learning Methods for Acquiring Compressed Liquid Densities of 1,1,1,2,3,3,3-Heptafluoropropane (R227ea via Song and Mason Equation, Support Vector Machine, and Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Hao Li

    2016-01-01

    Full Text Available 1,1,1,2,3,3,3-Heptafluoropropane (R227ea is a good refrigerant that reduces greenhouse effects and ozone depletion. In practical applications, we usually have to know the compressed liquid densities at different temperatures and pressures. However, the measurement requires a series of complex apparatus and operations, wasting too much manpower and resources. To solve these problems, here, Song and Mason equation, support vector machine (SVM, and artificial neural networks (ANNs were used to develop theoretical and machine learning models, respectively, in order to predict the compressed liquid densities of R227ea with only the inputs of temperatures and pressures. Results show that compared with the Song and Mason equation, appropriate machine learning models trained with precise experimental samples have better predicted results, with lower root mean square errors (RMSEs (e.g., the RMSE of the SVM trained with data provided by Fedele et al. [1] is 0.11, while the RMSE of the Song and Mason equation is 196.26. Compared to advanced conventional measurements, knowledge-based machine learning models are proved to be more time-saving and user-friendly.

  8. Evaluation of longitudinal loading of tank trains during motion in longitudinal changes of gradient

    Directory of Open Access Journals (Sweden)

    S.V. Myamlin

    2013-06-01

    Full Text Available Purpose. To research the tank train longitudinal loading during motion by track sections with changes of gradient. The trains of different length that consist of bogie tank wagons should be examined. Influence of cargo type on longitudinal loading of train during motion in concave section of track should be evaluated. Methodology. The level of the largest longitudinal forces was estimated by mathematical simulation. It was assumed that change of gradient is formed by two grades with baffle platforms, length 50 meters, so that the algebraic difference of limiting grades vary from 10‰ to 40‰, pitch 10‰. The initial speeds were 40, 60, 80, 100, 120 km/h. For evaluation of the longitudinal loading the regulating braking and motion "by coasting" was considered. For evaluation of buffing loads the entry to the concave gradient change of expanded train is considered, and in order to determine the quasi-static forces the compressed train is considered. Findings. As a result of calculations the dependencies of maximal longitudinal forces in the trains on the cargo type, the algebraic difference of the grades, the number of tank wagons, the initial speed, motion modes, and initial gaps condition in the train were obtained. Originality. The longitudinal loading of freight cars of different length formed by the similar bogie tank wagons with one locomotive was obtained. The locomotive is placed in the train head during motion in concave track sections with various algebraic difference of the grades "on coasting" and during the regulating braking mode. The obtained results can be used for parameters standardization of profile elevation of the track. Practical value. The obtained results show that during operation of tank trains on track sections of complex breakage the most dangerous is regulating braking of preliminary compressed trains during entering on concave parts of track. Level of the greatest buffing and quasi-static longitudinal forces is

  9. RADON reconstruction in longitudinal phase space

    International Nuclear Information System (INIS)

    Mane, V.; Peggs, S.; Wei, J.

    1997-01-01

    Longitudinal particle motion in circular accelerators is typically monitoring by one dimensional (1-D) profiles. Adiabatic particle motion in two dimensional (2-D) phase space can be reconstructed with tomographic techniques, using 1-D profiles. A computer program RADON has been developed in C++ to process digitized mountain range data and perform the phase space reconstruction for the AGS, and later for Relativistic Heavy Ion Collider (RHIC)

  10. Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats

    Directory of Open Access Journals (Sweden)

    Hye Suk Hwang

    2011-01-01

    Full Text Available Using spontaneously hypertensive rats (SHR, this study investigated whether electroacupuncture (EA could reduce early stage hypertension by examining nitric oxide (NO levels in plasma and nitric oxide synthase (NOS levels in the mesenteric resistance artery. EA was applied to the acupuncture point Governor Vessel 20 (GV20 or to a non-acupuncture point in the tail twice weekly for 3 weeks under anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY rats, blood pressure was determined the day after EA treatment by the tail-cuff method. We measured plasma NO concentration, and evaluated endothelial NO syntheses (eNOS and neuronal NOS (nNOS protein expression in the mesenteric artery. Systolic blood pressure (SBP and diastolic blood pressure (DBP were lower after 3 weeks of GV20 treatment than EA at non-acupuncture point and no treatment control in SHR. nNOS expression by EA was significantly different between both WKY and no treatment SHR control, and EA at GV20 in SHR. eNOS expression was significantly high in EA at GV 20 compared with no treatment control. In conclusion, EA could attenuate the blood pressure elevation of SHR, along with enhancing NO/NOS activity in the mesenteric artery in SHR.

  11. Joint two-part Tobit models for longitudinal and time-to-event data.

    Science.gov (United States)

    Dagne, Getachew A

    2017-11-20

    In this article, we show how Tobit models can address problems of identifying characteristics of subjects having left-censored outcomes in the context of developing a method for jointly analyzing time-to-event and longitudinal data. There are some methods for handling these types of data separately, but they may not be appropriate when time to event is dependent on the longitudinal outcome, and a substantial portion of values are reported to be below the limits of detection. An alternative approach is to develop a joint model for the time-to-event outcome and a two-part longitudinal outcome, linking them through random effects. This proposed approach is implemented to assess the association between the risk of decline of CD4/CD8 ratio and rates of change in viral load, along with discriminating between patients who are potentially progressors to AIDS from patients who do not. We develop a fully Bayesian approach for fitting joint two-part Tobit models and illustrate the proposed methods on simulated and real data from an AIDS clinical study. Copyright © 2017 John Wiley & Sons, Ltd.

  12. Longitudinal in vivo MR imaging of live earthworms.

    Science.gov (United States)

    Budán, Ferenc; Kovács, Noémi; Engelmann, Péter; Horváth, Ildikó; Veres, Dániel S; Németh, Péter; Szigeti, Krisztián; Máthé, Domokos

    2014-11-01

    Earthworm (Oligochaeta, Lumbricidae) species are used widely in eco-toxicological tests especially with contaminated soils. These long-term tests are reliable, but a high sample size is needed. Magnetic resonance imaging (MRI) can produce fast, robust, sensitive, and longitudinal morphological results using a small sample size. Performing longitudinal in vivo examinations of earthworms using MRI requires the need for anesthetics to completely avoid earthworm's moving. Our goal was to develop a simple and non-invasive method to anesthetize earthworms for in vivo longitudinal imaging studies. We investigated a number of different anesthesia methods and found that propan-2-ol and its vapor was optimal. We used a commercial sequential nanoScan® PET/MRI system (Mediso Ltd, Hungary, Budapest) to explore feasibility of MR imaging in immobilized earthworms. It was possible to visualize via micro MRI the brain, gastrointestinal tract, seminal vesicles, calciferous gland (Morren gland), and main blood vessels of the circulatory system. Our findings show the possibilities to examine changes in morphology using MRI of certain organs using a reversible, long-term immobilization method. © 2014 Wiley Periodicals, Inc.

  13. Estimates of post-acceleration longitudinal bunch compression

    International Nuclear Information System (INIS)

    Judd, D.L.

    1977-01-01

    A simple analytic method is developed, based on physical approximations, for treating transient implosive longitudinal compression of bunches of heavy ions in an accelerator system for ignition of inertial-confinement fusion pellet targets. Parametric dependences of attainable compressions and of beam path lengths and times during compression are indicated for ramped pulsed-gap lines, rf systems in storage and accumulator rings, and composite systems, including sections of free drift. It appears that for high-confidence pellets in a plant producing 1000 MW of electric power the needed pulse lengths cannot be obtained with rings alone unless an unreasonably large number of them are used, independent of choice of rf harmonic number. In contrast, pulsed-gap lines alone can meet this need. The effects of an initial inward compressive drift and of longitudinal emittance are included

  14. Can enterprise architectures reduce failure in development projects?

    NARCIS (Netherlands)

    Janssen, M.F.W.H.A.; Klievink, B.

    2012-01-01

    Purpose: Scant attention has been given to the role of enterprise architecture (EA) in relationship to risk management in information system development projects. Even less attention has been given to the inter-organizational setting. The aim of this paper is to better understand this relationship.

  15. Thoracic posterior longitudinal ligament ossification in a fixed population; longitudinal radiological observations

    International Nuclear Information System (INIS)

    Ono, Minoru; Russell, W.J.; Kudo, Sho.

    1984-05-01

    All lateral chest radiographs of 34 persons with posterior longitudinal ligament ossification (PLLO) in the thoracic spine were reviewed for date of its onset and its progress. These observations spanned as long as 18 years. Upper mid-thoracic PLLO first appeared under the age of 40, then increased in extent in the vertical axis until the age of 50. Lower thoracic PLLO occurred later than upper mid-thoracic PLLO. In the lower thoracic and lumbar regions, degeneration of the vertebrae and discs apparently were focal factors which triggered the development of thoracic PLLO. PLLO apparently developed in a different way in the upper and mid-thoracic regions, where the vertebrae and discs were unremarkable at the time of its initial appearance, and degenerative abnormalities did not predispose to it. (author)

  16. Study of the decay of hot nuclear systems formed in Au-induced reactions at E/A=60 MeV

    International Nuclear Information System (INIS)

    Delis, D.N.; Colonna, N.; Sui, Q.; Tso, K.

    1993-01-01

    Multifragment production was measured for the 197 Au + 12 C, 27 Al, 51 V, 63 Cu and 197 Au reactions at E/A= 60 MeV. Comparison of experimental observables to calculations with a dynamical code coupled to a statistical model indicates agreement with some features of the experimental data. Furthermore the logarithms of the branching ratios for binary, ternary, quaternary, and quinary decays plotted as a function of E -1/2 show a linear dependence that ,strongly suggests a statistical competition between the various multifraigment channels. Finally, by utilizing the momentum tensor, the shape of the most central events in momentum space has been determined

  17. Fitting the Fractional Polynomial Model to Non-Gaussian Longitudinal Data

    Directory of Open Access Journals (Sweden)

    Ji Hoon Ryoo

    2017-08-01

    Full Text Available As in cross sectional studies, longitudinal studies involve non-Gaussian data such as binomial, Poisson, gamma, and inverse-Gaussian distributions, and multivariate exponential families. A number of statistical tools have thus been developed to deal with non-Gaussian longitudinal data, including analytic techniques to estimate parameters in both fixed and random effects models. However, as yet growth modeling with non-Gaussian data is somewhat limited when considering the transformed expectation of the response via a linear predictor as a functional form of explanatory variables. In this study, we introduce a fractional polynomial model (FPM that can be applied to model non-linear growth with non-Gaussian longitudinal data and demonstrate its use by fitting two empirical binary and count data models. The results clearly show the efficiency and flexibility of the FPM for such applications.

  18. A Gaussian mixture clustering model for characterizing football players using the EA Sports' FIFA video game system. [Modelo basado en agrupamiento de mixturas Gaussianas para caracterizar futbolistas utilizando el sistema de videojuegos FIFA de EA Sports].

    Directory of Open Access Journals (Sweden)

    César Soto-Valero

    2017-07-01

    Full Text Available The generation and availability of football data has increased considerably last decades, mostly due to its popularity and also because of technological advances. Gaussian mixture clustering models represents a novel approach to exploring and analyzing performance data in sports. In this paper, we use principal components analysis in conjunction with a model-based Gaussian clustering method with the purpose of characterizing professional football players. Our model approach is tested using 40 attributes from EA Sports' FIFA video game series system, corresponding to 7705 European players. Clustering results reveal a clear distinction among different performance indicators, representing four different roles in the team. Players were labeled according to these roles and a gradient tree boosting model was used for ranking attributes regarding to its importance. We found that the dribbling skill is the most discriminating variable among the different clustered players’ profiles. Resumen En las últimas décadas se ha visto un incremento considerable en la generación y disponibilidad de datos de fútbol, esto se debe fundamentalmente a la popularidad de este deporte así como a los avances tecnológicos realizados en este campo. Los modelos de agrupamiento basados en mixturas Gaussianas representan un enfoque novedoso para explorar y analizar datos de desempeño deportivo. En el presente trabajo, se lleva a cabo una caracterización de jugadores profesionales de fútbol utilizando técnicas de análisis de componentes principales y agrupamiento basados en mixturas Gaussianas. El modelo presentado es comprobado utilizando datos del sistema de videojuegos FIFA de EA Sports, dichos datos representan 40 atributos correspondientes a 7705 futbolistas europeos. Los resultados del agrupamiento revelan una clara distinción entre algunos indicadores de desempeño, los cuales corresponden a cuatro roles diferentes en el equipo. Consecuentemente, los

  19. Fostering marginalized youths' political participation: longitudinal roles of parental political socialization and youth sociopolitical development.

    Science.gov (United States)

    Diemer, Matthew A

    2012-09-01

    This study examines the roles of parental political socialization and the moral commitment to change social inequalities in predicting marginalized youths' (defined here as lower-SES youth of color) political participation. These issues are examined by applying structural equation modeling to a longitudinal panel of youth. Because tests of measurement invariance suggested racial/ethnic heterogeneity, the structural model was fit separately for three racial/ethnic groups. For each group, parental political socialization: discussion predicted youths' commitment to produce social change and for two groups, longitudinally predicted political participation. This study contributes to the literature by examining civic/political participation among disparate racial/ethnic groups, addresses an open scholarly question (whether youths' commitment to create social change predicts their "traditional" participation), and emphasizes parents' role in fostering marginalized youths' civic and political participation.

  20. Longitudinal compression of heavy-ion beams with minimum requirements on final focus

    International Nuclear Information System (INIS)

    Ho, D.D.M.; Bangerter, R.O.; Mark, J.W.K.; Brandon, S.T.; Lee, E.P.

    1986-01-01

    A method is developed to compress a heavy-ion beam longitudinally in such a way that the compressed pulse has a constant line-charge density profile and uniform longitudinal momentum. These conditions may be important from the standpoint of final focusing. By realizing the similarity of the equations that describe the 1-D charged-particle motion to the equations that describe 1-D ideal gas flow, the evolution of lambda and the velocity tilt can be calculated using the method of characteristics developed for unsteady supersonic gasdynamics. Particle simulations confirm the theory. Various schemes for pulse shaping have been investigated

  1. Environmental Assessment and Finding of No Significant Impact: The Nevada Test Site Development Corporations's Desert Rock Sky Park at the Nevada Test Site

    Energy Technology Data Exchange (ETDEWEB)

    N/A

    2000-03-01

    The United States Department of Energy has prepared an Environmental Assessment (DOE/EA-1300) (EA) which analyzes the potential environmental effects of developing operating and maintaining a commercial/industrial park in Area 22 of the Nevada Test Site, between Mercury Camp and U.S. Highway 95 and east of Desert Rock Airport. The EA evaluates the potential impacts of infrastructure improvements necessary to support fill build out of the 512-acre Desert Rock Sky Park. Two alternative actions were evaluated: (1) Develop, operate and maintain a commercial/industrial park in Area 22 of the Nevada Test Site, and (2) taking no action. The purpose and need for the commercial industrial park are addressed in Section 1.0 of the EA. A detailed description of the proposed action and alternatives is in section 2.0. Section 3.0 describes the affected environment. Section 4.0 the environmental consequences of the proposed action and alternative. Cumulative effects are addressed in Section 5.0. Mitigation measures are addressed in Section 6.0. The Department of Energy determined that the proposed action of developing, operating and maintaining a commercial/industrial park in Area 22 of the Nevada Test Site would best meet the needs of the agency.

  2. Longitudinal study of spatial working memory development in young children.

    Science.gov (United States)

    Tsujii, Takeo; Yamamoto, Eriko; Masuda, Sayako; Watanabe, Shigeru

    2009-05-27

    This study longitudinally compared activity in the frontal cortex during a spatial working memory task between 5-year-old and 7-year-old children using near-infrared spectroscopy. Eight children participated in this study twice, once at 5 years and once at 7 years of age. Behavioral analysis showed that older children performed the working memory task more precisely and more rapidly than younger children. Near-infrared spectroscopy analysis showed that right hemisphere dominance was observed in older children, whereas no hemispheric difference was apparent in younger children. Children with strengthened lateralization showed improved performance from 5 to 7 years. We therefore offer the first demonstration of the developmental changes in frontal cortical activation during spatial working memory tasks during the preschool period.

  3. Longitudinal Space Charge in the SPS

    CERN Document Server

    Lasheen, Alexandre

    2016-01-01

    Longitudinal instabilities due to the SPS beam coupling impedance are a major issue for future projects and it is essential to have an accurate SPS impedance model to study them. The longitudinal space charge effect can be modelled by a pure reactive impedance and should also be included in simulations as it may have an impact at low energy. In this Note, the effect of the longitudinal space charge in the SPS is evaluated by taking into account the variation of the transverse beam size and vacuum chamber geometry along the ring. Scaling laws are used to investigate what are the most important parameters for the evaluation of the longitudinal space charge impedance.

  4. Cross-Sectional Analysis of Longitudinal Mediation Processes.

    Science.gov (United States)

    O'Laughlin, Kristine D; Martin, Monica J; Ferrer, Emilio

    2018-01-01

    Statistical mediation analysis can help to identify and explain the mechanisms behind psychological processes. Examining a set of variables for mediation effects is a ubiquitous process in the social sciences literature; however, despite evidence suggesting that cross-sectional data can misrepresent the mediation of longitudinal processes, cross-sectional analyses continue to be used in this manner. Alternative longitudinal mediation models, including those rooted in a structural equation modeling framework (cross-lagged panel, latent growth curve, and latent difference score models) are currently available and may provide a better representation of mediation processes for longitudinal data. The purpose of this paper is twofold: first, we provide a comparison of cross-sectional and longitudinal mediation models; second, we advocate using models to evaluate mediation effects that capture the temporal sequence of the process under study. Two separate empirical examples are presented to illustrate differences in the conclusions drawn from cross-sectional and longitudinal mediation analyses. Findings from these examples yielded substantial differences in interpretations between the cross-sectional and longitudinal mediation models considered here. Based on these observations, researchers should use caution when attempting to use cross-sectional data in place of longitudinal data for mediation analyses.

  5. Prenatal Development of Crocodylus niloticus niloticus Laurenti, 1768

    Czech Academy of Sciences Publication Activity Database

    Peterka, Miroslav; Sire, J. Y.; Hovořáková, Mária; Procházka, Jan; Fougeirol, L.; Peterková, Renata; Viriot, L.

    2010-01-01

    Roč. 314, č. 5 (2010), s. 353-368 ISSN 1552-5007 R&D Projects: GA ČR(CZ) GA304/07/0223 Institutional research plan: CEZ:AV0Z50390512 Keywords : crocodile s * prenatal development Subject RIV: EA - Cell Biology Impact factor: 2.373, year: 2010

  6. Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder.

    Science.gov (United States)

    McLaughlin, Kristine; Travers, Brittany G; Dadalko, Olga I; Dean, Douglas C; Tromp, Do; Adluru, Nagesh; Destiche, Daniel; Freeman, Abigail; Prigge, Molly D; Froehlich, Alyson; Duffield, Tyler C; Zielinski, Brandon A; Bigler, Erin D; Lange, Nicholas; Anderson, Jeff S; Alexander, Andrew L; Lainhart, Janet E

    2018-03-01

    The thalamus is a key sensorimotor relay area that is implicated in autism spectrum disorder (ASD). However, it is unknown how the thalamus and white-matter structures that contain thalamo-cortical fiber connections (e.g., the internal capsule) develop from childhood into adulthood and whether this microstructure relates to basic motor challenges in ASD. We used diffusion weighted imaging in a cohort-sequential design to assess longitudinal development of the thalamus, and posterior- and anterior-limbs of the internal capsule (PLIC and ALIC, respectively) in 89 males with ASD and 56 males with typical development (3-41 years; all verbal). Our results showed that the group with ASD exhibited different developmental trajectories of microstructure in all regions, demonstrating childhood group differences that appeared to approach and, in some cases, surpass the typically developing group in adolescence and adulthood. The PLIC (but not ALIC nor thalamus) mediated the relation between age and finger-tapping speed in both groups. Yet, the gap in finger-tapping speed appeared to widen at the same time that the between-group gap in the PLIC appeared to narrow. Overall, these results suggest that childhood group differences in microstructure of the thalamus and PLIC become less robust in adolescence and adulthood. Further, finger-tapping speed appears to be mediated by the PLIC in both groups, but group differences in motor speed that widen during adolescence and adulthood suggest that factors beyond the microstructure of the thalamus and internal capsule may contribute to atypical motor profiles in ASD. Autism Res 2018, 11: 450-462. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Microstructure of the thalamus, a key sensory and motor brain area, appears to develop differently in individuals with autism spectrum disorder (ASD). Microstructure is important because it informs us of the density and organization of different brain tissues. During

  7. The Israeli EA-FEL Upgrade Towards Long Pulse Operation for Ultra-High Resolution Single Pulse Coherent Spectroscopy

    CERN Document Server

    Gover, A; Kanter, M; Kapilevich, B; Litvak, B; Peleg, S; Socol, Y; Volshonok, M

    2005-01-01

    The Israeli Electrostatic Accelerator FEL (EA-FEL) is now being upgraded towards long pulse (1005s) operation and ultra-high resolution (10(-6)) single pulse coherent spectroscopy. We present quantitative estimations regarding the applications of controlled radiation chirp for spectroscopic applications with pulse-time Fourier Transform limited spectral resolution. Additionally, we describe a novel extraction-efficiency-improving scheme based on increase of accelerating voltage (boosting) after saturation is achieved. The efficiency of the proposed scheme is confirmed by theoretical and numerical calculations. The latter are performed using software, based on 3D space-frequency domain model. The presentation provides an overview of the upgrade status: the high-voltage terminal is being reconfigured to accept the accelerating voltage boost system; a new broad band low-loss resonator is being manufactured; multi-stage depressed collector is assembled.

  8. Relationship of working mothers' parenting style and consistency to early childhood development: a longitudinal investigation.

    Science.gov (United States)

    Tong, Lian; Shinohara, Ryoji; Sugisawa, Yuka; Tanaka, Emiko; Maruyama, Akiko; Sawada, Yuko; Ishi, Yukiko; Anme, Tokie

    2009-10-01

    This paper is a report of a longitudinal study of the relationship of working mothers' parenting style to their children's social competence and vocabulary/ motor/intellectual development. With an increasing number of women choosing to remain in the workforce after starting a family, there has been a concomitant increase in use of non-parental childcare facilities to help look after the child while the mother is at work. This increase in non-parental care has led to a dramatic change in the traditional child-rearing environment. Long-term investigations were conducted over a period of 2 years in 41 Japanese government-licensed childcare facilities. Child development was evaluated by childcare professionals and parenting style was assessed by questionnaire. A total of 504 children and their mothers participated in the study. Data collection was carried out in 2004 and 2006. We found that the changes in parenting style were statistically significantly related to children's development after 2 years. For instance, changes in the parent-child playing routine contributed to the child's social competence (odds ratio = 11.088). Variation in working mothers' disciplinary practices was also associated with children's vocabulary development after 2 years (odds ratio = 2246). Working mothers should increase interactions with their children in their free time to reduce the risk of developmental delay. Daily childcare support provided by family members or social organizations for long-term working mothers is helpful in mediating the negative relationship of mothers' working with children's development.

  9. Development of numerical processing in children with typical and dyscalculic arithmetic skills—a longitudinal study

    Science.gov (United States)

    Landerl, Karin

    2013-01-01

    Numerical processing has been demonstrated to be closely associated with arithmetic skills, however, our knowledge on the development of the relevant cognitive mechanisms is limited. The present longitudinal study investigated the developmental trajectories of numerical processing in 42 children with age-adequate arithmetic development and 41 children with dyscalculia over a 2-year period from beginning of Grade 2, when children were 7; 6 years old, to beginning of Grade 4. A battery of numerical processing tasks (dot enumeration, non-symbolic and symbolic comparison of one- and two-digit numbers, physical comparison, number line estimation) was given five times during the study (beginning and middle of each school year). Efficiency of numerical processing was a very good indicator of development in numerical processing while within-task effects remained largely constant and showed low long-term stability before middle of Grade 3. Children with dyscalculia showed less efficient numerical processing reflected in specifically prolonged response times. Importantly, they showed consistently larger slopes for dot enumeration in the subitizing range, an untypically large compatibility effect when processing two-digit numbers, and they were consistently less accurate in placing numbers on a number line. Thus, we were able to identify parameters that can be used in future research to characterize numerical processing in typical and dyscalculic development. These parameters can also be helpful for identification of children who struggle in their numerical development. PMID:23898310

  10. A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species

    International Nuclear Information System (INIS)

    Large, Martin; Reichert, Sebastian; Hehlgans, Stephanie; Fournier, Claudia; Rödel, Claus; Rödel, Franz

    2014-01-01

    A discontinuous dose response relationship is a major characteristic of the anti-inflammatory effects of low-dose X-irradiation therapy. Although recent data indicate an involvement of a variety of molecular mechanisms in these characteristics, the impact of reactive oxygen species (ROS) production to give rise or contribute to these phenomena in endothelial cells (EC) remains elusive. HUVEC derived immortalized EA.hy926 cells were stimulated by tumor necrosis factor-α (TNF-α, 20 ng/ml) 4 h before irradiation with doses ranging from 0.3 to 1 Gy. To analyse DNA repair capacity, phospho-histone H2AX foci were assayed at 1 h, 4 h and 24 h after irradiation. ROS production and superoxide dismutase (SOD) activity were analysed by fluorometric 2′,7′-dichlorodihydrofluorescein-diacetate (H2DCFDA) and colorimetric assays. A functional impact of ROS on γH2AX production was analysed by treatment with the scavenger N-acetyl-L-cysteine (NAC). Irrespective of stimulation by TNF-α, EA.hy926 cells revealed a linear dose response characteristic of γH2AX foci detection at 1 h and 4 h after irradiation. By contrast, we observed a discontinuity in residual γH2AX foci detection at 24 h after irradiation with locally elevated values following a 0.5 Gy exposure that was abolished by inhibition of ROS by NAC. Moreover, SOD protein expression was significantly decreased at doses of 0.5 Gy and 0.7 Gy concomitant with a reduced SOD activity. These data implicate a non-linear regulation of ROS production and SOD activity in EA.hy926 EC following irradiation with doses < 1 Gy that may contribute to a discontinuous dose-response relationship of residual γH2AX foci detection

  11. Spatial distribution and longitudinal development of deep cortical sulcal landmarks in infants.

    Science.gov (United States)

    Meng, Yu; Li, Gang; Lin, Weili; Gilmore, John H; Shen, Dinggang

    2014-10-15

    Sulcal pits, the locally deepest points in sulci of the highly convoluted and variable cerebral cortex, are found to be spatially consistent across human adult individuals. It is suggested that sulcal pits are genetically controlled and have close relationships with functional areas. To date, the existing imaging studies of sulcal pits are mainly focused on adult brains, yet little is known about the spatial distribution and temporal development of sulcal pits in the first 2 years of life, which is the most dynamic and critical period of postnatal brain development. Studying sulcal pits during this period would greatly enrich our limited understandings of the origins and developmental trajectories of sulcal pits, and would also provide important insights into many neurodevelopmental disorders associated with abnormal cortical foldings. In this paper, by using surface-based morphometry, for the first time, we systemically investigated the spatial distribution and temporal development of sulcal pits in major cortical sulci from 73 healthy infants, each with three longitudinal 3T MR scans at term birth, 1 year, and 2 years of age. Our results suggest that the spatially consistent distributions of sulcal pits in major sulci across individuals have already existed at term birth and this spatial distribution pattern keeps relatively stable in the first 2 years of life, despite that the cerebral cortex expands dramatically and the sulcal depth increases considerably during this period. Specially, the depth of sulcal pits increases regionally heterogeneously, with more rapid growth in the high-order association cortex, including the prefrontal and temporal cortices, than the sensorimotor cortex in the first 2 years of life. Meanwhile, our results also suggest that there exist hemispheric asymmetries of the spatial distributions of sulcal pits in several cortical regions, such as the central, superior temporal and postcentral sulci, consistently from birth to 2 years of age

  12. A Multimodal Imaging Approach for Longitudinal Evaluation of Bladder Tumor Development in an Orthotopic Murine Model.

    Directory of Open Access Journals (Sweden)

    Chantal Scheepbouwer

    Full Text Available Bladder cancer is the fourth most common malignancy amongst men in Western industrialized countries with an initial response rate of 70% for the non-muscle invasive type, and improving therapy efficacy is highly needed. For this, an appropriate, reliable animal model is essential to gain insight into mechanisms of tumor growth for use in response monitoring of (new agents. Several animal models have been described in previous studies, but so far success has been hampered due to the absence of imaging methods to follow tumor growth non-invasively over time. Recent developments of multimodal imaging methods for use in animal research have substantially strengthened these options of in vivo visualization of tumor growth. In the present study, a multimodal imaging approach was addressed to investigate bladder tumor proliferation longitudinally. The complementary abilities of Bioluminescence, High Resolution Ultrasound and Photo-acoustic Imaging permit a better understanding of bladder tumor development. Hybrid imaging modalities allow the integration of individual strengths to enable sensitive and improved quantification and understanding of tumor biology, and ultimately, can aid in the discovery and development of new therapeutics.

  13. The development condition of longitudinal channels of a Lower Cretaceous formation and its perspective for sandstone type uranium deposits in the Erlian basin, northern China

    International Nuclear Information System (INIS)

    Qin, M.; Xu, Q.; Liu, W.; Song, J.; Chen, D.; Wei, S.

    2014-01-01

    The palaeochannel, which is classified as basal and interformational types on the basis of geological setting, is an important host for the sandstone type uranium deposit. Diversities exist in development conditions and uranium minerogenetic potential of the two types of palaeochanneles. The Erlian basin, about 105 km"2 and adjacent to channel-type uranium deposit provinces in Russia and Mongolia, is one of main uraniferous basins in the north of China. It is significant to research into development conditions of palaeochannels for uranium mineral exploration in the Erlian basin. 1. Geological background: The Erlian basin consists of five depressions which divide the basin and form alternations with uplifts and depressions. Sedimentary capping strata of the basin mainly is the Lower Cretaceous Bayanhua group (K1b) which consists of the Aershan group (K1ba), Tenger group (K1bt) and Saihan group (K1bs) from bottom to top. The Saihan group, which is the product in the phase of depression, is the most important uranous strata in the Erlian basin. 2. Development characteristic and condition of the longitudinal palaeochannel of the Saihan formation: Large-scale longitudinal multi-palaeochannels are identified in the center and northeast of the basin, such as the QiHaRiGeTu-SaiHanGaoBi palaeochannel (CH01), BaYanWuLa palaeochannel (CH02) and GaoLiHan palaeochanne l(CH03), et al., which character the length from several 10s of km to 100 km, width of several 10s of km and thickness of sand bodies from 20 m to 130 m, more or less. Palaeochannels of the Saihan formation are interformational type because the underlay is argillite at the top of the Tenggeer formation. Restrictive geological environments and conditions are necessary to form longitudinal channels and mainly are as follows: (1) the basin in the sustained step of depression; (2) sharp gradient (>5°?) in parts of sub-depressions and sufficient sedimentary supply from the upstream; (3) elongate erosional lowlands or

  14. Which emotional regulatory strategy makes Chinese adolescents happier? A longitudinal study.

    Science.gov (United States)

    Sang, Biao; Deng, Xinmei; Luan, Ziyan

    2014-12-01

    Growing interest in emotion regulation is reflected in the studies of cognitive and social development. However, the extant studies mainly highlight how emotion regulation develops based on a western value system. This study utilised a longitudinal design to examine the development of emotion regulation and explored the contributions of different regulatory strategies to emotion experience regarding the early adolescent development period in a Chinese population. A total of 303 Chinese adolescents (age range = 10-14 years) were followed up in a three-phase longitudinal study for 3 years. In each phase of the study, participants completed Adolescents Emotion Regulation Questionnaire and Daily Emotion Scale. Results of hierarchical linear regressions revealed that Chinese adolescents reported more down-regulation. Down-regulation is more effective than up-regulation in enhancing desirable emotion experience and reducing undesirable emotion experience during adolescents' development. Also, the adaptive functions of emotional regulatory strategies in Chinese background were discussed. © 2014 International Union of Psychological Science.

  15. Composite marginal quantile regression analysis for longitudinal adolescent body mass index data.

    Science.gov (United States)

    Yang, Chi-Chuan; Chen, Yi-Hau; Chang, Hsing-Yi

    2017-09-20

    Childhood and adolescenthood overweight or obesity, which may be quantified through the body mass index (BMI), is strongly associated with adult obesity and other health problems. Motivated by the child and adolescent behaviors in long-term evolution (CABLE) study, we are interested in individual, family, and school factors associated with marginal quantiles of longitudinal adolescent BMI values. We propose a new method for composite marginal quantile regression analysis for longitudinal outcome data, which performs marginal quantile regressions at multiple quantile levels simultaneously. The proposed method extends the quantile regression coefficient modeling method introduced by Frumento and Bottai (Biometrics 2016; 72:74-84) to longitudinal data accounting suitably for the correlation structure in longitudinal observations. A goodness-of-fit test for the proposed modeling is also developed. Simulation results show that the proposed method can be much more efficient than the analysis without taking correlation into account and the analysis performing separate quantile regressions at different quantile levels. The application to the longitudinal adolescent BMI data from the CABLE study demonstrates the practical utility of our proposal. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  16. An Evaluation of PET Based on Longitudinal Data.

    Science.gov (United States)

    Mandeville, Garrett K.

    Although teacher inservice programs based on Madeline Hunter's Program for Effective Teaching (PET) have become very popular in U.S. schools, there is little evidence that the Hunter model ultimately results in increased student achievement. This longitudinal study attempts to evaluate the effects of Hunter-based staff development programs on…

  17. Ultrastructure, development, and homology of insect embryonic cuticles

    Czech Academy of Sciences Publication Activity Database

    Konopová, Barbora; Zrzavý, Jan

    2005-01-01

    Roč. 264, č. 3 (2005), s. 339-362 ISSN 0362-2525 R&D Projects: GA ČR(CZ) GD206/03/H034 Institutional research plan: CEZ:AV0Z50070508 Keywords : embryonic development * cuticle * metamorphosis Subject RIV: EA - Cell Biology Impact factor: 1.421, year: 2005

  18. Longitudinal change in the neural bases of adolescent social self-evaluations: effects of age and pubertal development.

    Science.gov (United States)

    Pfeifer, Jennifer H; Kahn, Lauren E; Merchant, Junaid S; Peake, Shannon J; Veroude, Kim; Masten, Carrie L; Lieberman, Matthew D; Mazziotta, John C; Dapretto, Mirella

    2013-04-24

    Self-evaluations undergo significant transformation during early adolescence, developing in parallel with the heightened complexity of teenagers' social worlds. Intuitive theories of adolescent development, based in part on animal work, suggest that puberty is associated with neural-level changes that facilitate a "social reorientation" (Nelson et al., 2005). However, direct tests of this hypothesis using neuroimaging are limited in humans. This longitudinal fMRI study examined neurodevelopmental trajectories associated with puberty, self-evaluations, and the presumed social reorientation during the transition from childhood to adolescence. Participants (N = 27, mean age = 10.1 and 13.1 years at time points one and two, respectively) engaged in trait evaluations of two targets (the self and a familiar fictional other), across two domains of competence (social and academic). Responses in ventromedial PFC increased with both age and pubertal development during self-evaluations in the social domain, but not in the academic domain. These results suggest that changes in social self-evaluations are intimately connected with biology, not just peer contexts, and provide important empirical support for the relationship between neurodevelopment, puberty, and social functioning.

  19. Charge correlations in the breakup of gold projectiles in reactions at E/A=600 MeV

    International Nuclear Information System (INIS)

    Kreutz, P.

    1992-09-01

    In the present thesis the charge correlations in the breakup of gold projectiles in heavy ion collisions at an incident energy of E/A=600 MeV were studied. Thereby it has been proved that the sum of the charges from the projectile source under exclusion of the protons (Z bound ) is saliently suited for the classification of the nuclear reactions. At large values of Z bound we fins fission and spallation reactions. For smaller values of Z bound we observe events with an increasing number of medium-heavy fragments. Thereby the multifragment events appear in the Dalitz diagrams as a continuation of more symmetric becoming spallation events. In reactions with Z bound ≅ 35 the conditions for the formation of medium-heavy fragments are optimal and the multifragment events represent the dominating exit channel. A mean multiplicity of the medium-heavy fragments of ≅ 4 is reached. (orig./HSI) [de

  20. The Interplay of Population Size and Mutation Probability in the (1+λ) EA on OneMax

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2017-01-01

    The ((Formula presented.)) EA with mutation probability c / n, where (Formula presented.) is an arbitrary constant, is studied for the classical OneMax function. Its expected optimization time is analyzed exactly (up to lower order terms) as a function of c and (Formula presented.). It turns out...... that 1 / n is the only optimal mutation probability if (Formula presented.), which is the cut-off point for linear speed-up. However, if (Formula presented.) is above this cut-off point then the standard mutation probability 1 / n is no longer the only optimal choice. Instead, the expected number...... of generations is (up to lower order terms) independent of c, irrespectively of it being less than 1 or greater. The theoretical results are obtained by a careful study of order statistics of the binomial distribution and variable drift theorems for upper and lower bounds. Experimental supplements shed light...

  1. Correction of longitudinal errors in accelerators for heavy-ion fusion

    International Nuclear Information System (INIS)

    Sharp, W.M.; Callahan, D.A.; Barnard, J.J.; Langdon, A.B.; Fessenden, T.J.

    1993-01-01

    Longitudinal space-charge waves develop on a heavy-ion inertial-fusion pulse from initial mismatches or from inappropriately timed or shaped accelerating voltages. Without correction, waves moving backward along the beam can grow due to the interaction with their resistivity retarded image fields, eventually degrading the longitudinal emittance. A simple correction algorithm is presented here that uses a time-dependent axial electric field to reverse the direction of backward-moving waves. The image fields then damp these forward-moving waves. The method is demonstrated by fluid simulations of an idealized inertial-fusion driver, and practical problems in implementing the algorithm are discussed

  2. Atmospheric histories and global emissions of the anthropogenic hydrofluorocarbons HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa

    Science.gov (United States)

    Vollmer, Martin K.; Miller, Benjamin R.; Rigby, Matthew; Reimann, Stefan; Mühle, Jens; Krummel, Paul B.; O'Doherty, Simon; Kim, Jooil; Rhee, Tae Siek; Weiss, Ray F.; Fraser, Paul J.; Simmonds, Peter G.; Salameh, Peter K.; Harth, Christina M.; Wang, Ray H. J.; Steele, L. Paul; Young, Dickon; Lunder, Chris R.; Hermansen, Ove; Ivy, Diane; Arnold, Tim; Schmidbauer, Norbert; Kim, Kyung-Ryul; Greally, Brian R.; Hill, Matthias; Leist, Michael; Wenger, Angelina; Prinn, Ronald G.

    2011-04-01

    We report on ground-based atmospheric measurements and emission estimates of the four anthropogenic hydrofluorocarbons (HFCs) HFC-365mfc (CH3CF2CH2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). In situ measurements are from the global monitoring sites of the Advanced Global Atmospheric Gases Experiment (AGAGE), the System for Observations of Halogenated Greenhouse Gases in Europe (SOGE), and Gosan (South Korea). We include the first halocarbon flask sample measurements from the Antarctic research stations King Sejong and Troll. We also present measurements of archived air samples from both hemispheres back to the 1970s. We use a two-dimensional atmospheric transport model to simulate global atmospheric abundances and to estimate global emissions. HFC-365mfc and HFC-245fa first appeared in the atmosphere only ˜1 decade ago; they have grown rapidly to globally averaged dry air mole fractions of 0.53 ppt (in parts per trillion, 10-12) and 1.1 ppt, respectively, by the end of 2010. In contrast, HFC-227ea first appeared in the global atmosphere in the 1980s and has since grown to ˜0.58 ppt. We report the first measurements of HFC-236fa in the atmosphere. This long-lived compound was present in the atmosphere at only 0.074 ppt in 2010. All four substances exhibit yearly growth rates of >8% yr-1 at the end of 2010. We find rapidly increasing emissions for the foam-blowing compounds HFC-365mfc and HFC-245fa starting in ˜2002. After peaking in 2006 (HFC-365mfc: 3.2 kt yr-1, HFC-245fa: 6.5 kt yr-1), emissions began to decline. Our results for these two compounds suggest that recent estimates from long-term projections (to the late 21st century) have strongly overestimated emissions for the early years of the projections (˜2005-2010). Global HFC-227ea and HFC-236fa emissions have grown to average values of 2.4 kt yr-1

  3. A retrospective analysis of real-world use of the eaTracker® My Goals website by adults from Ontario and Alberta, Canada.

    Science.gov (United States)

    Lieffers, Jessica R L; Haresign, Helen; Mehling, Christine; Hanning, Rhona M

    2016-09-15

    Little is known about use of goal setting and tracking tools within online programs to support nutrition and physical activity behaviour change. In 2011, Dietitians of Canada added "My Goals," a nutrition and physical activity behaviour goal setting and tracking tool to their free publicly available self-monitoring website (eaTracker® ( http://www.eaTracker.ca/ )). My Goals allows users to: a) set "ready-made" SMART (Specific, Measurable, Attainable, Realistic, Time-related) goals (choice of n = 87 goals from n = 13 categories) or "write your own" goals, and b) track progress using the "My Goals Tracker." The purpose of this study was to characterize: a) My Goals user demographics, b) types of goals set, and c) My Goals Tracker use. Anonymous data on all goals set using the My Goals feature from December 6/2012-April 28/2014 by users ≥19y from Ontario and Alberta, Canada were obtained. This dataset contained: anonymous self-reported user demographic data, user set goals, and My Goals Tracker use data. Write your own goals were categorized by topic and specificity. Data were summarized using descriptive statistics. Multivariate binary logistic regression was used to determine associations between user demographics and a) goal topic areas and b) My Goals Tracker use. Overall, n = 16,511 goal statements (75.4 % ready-made; 24.6 % write your own) set by n = 8,067 adult users 19-85y (83.3 % female; mean age 41.1 ± 15.0y, mean BMI 28.8 ± 7.6kg/m(2)) were included for analysis. Overall, 33.1 % of ready-made goals were from the "Managing your Weight" category. Of write your own goal entries, 42.3 % were solely distal goals (most related to weight management); 38.6 % addressed nutrition behaviour change (16.6 % had unspecific general eating goals); 18.1 % addressed physical activity behaviour change (47.3 % had goals without information on exercise amount and type). Many write your own goals were poor quality (e.g., non-specific (e.g., missing

  4. Longitudinal dynamics of laser-cooled fast ion beams

    DEFF Research Database (Denmark)

    Weidemüller, M.; Eike, B.; Eisenbarth, U.

    1999-01-01

    We present recent results of our experiments on laser cooling of fast stored ion beams at the Heidelberg Test Storage Ring. The longitudinal motion of the ions is directly cooled by the light pressure force, whereas efficient transverse cooling is obtained indirectly by longitudinal-transverse co......We present recent results of our experiments on laser cooling of fast stored ion beams at the Heidelberg Test Storage Ring. The longitudinal motion of the ions is directly cooled by the light pressure force, whereas efficient transverse cooling is obtained indirectly by longitudinal....... When applying laser cooling in square-well buckets over long time intervals, hard Coulomb collisions suddenly disappear and the longitudinal temperature drops by about a factor of three. The observed longitudinal behaviour of the beam shows strong resemblance with the transition to an Coulomb...

  5. Longitudinal beam dynamics at transition crossing

    Energy Technology Data Exchange (ETDEWEB)

    Bogacz, S.A.

    1991-11-01

    A brief outline of the longitudinal single particle dynamics at transition is presented in terms of phase-space mappings. Simple quantitative prediction about the phase-space dilution is made. More realistic simulation (ESME) of the transition crossing is carried out (including various collective and single particle effects contributing to the longitudinal emittance blow up). The simulation takes into account the longitudinal space-charge force (bunch length oscillation), the transverse space-charge (the Umstaetter effect) and finally the dispersion of the momentum compaction factor (the Johnsen effect). As a result of this simulation one can separate relative strengths of the above mechanisms and study their individual effects on the longitudinal phase-space evolution, especially filamentation of the bunch and formation of a galaxy-like'' pattern. 7 refs., 2 figs.

  6. Loading Conditions and Longitudinal Strength

    DEFF Research Database (Denmark)

    Sørensen, Herman

    1995-01-01

    Methods for the calculation of the lightweight of the ship.Loading conditions satisfying draught, trim and intact stability requirements and analysis of the corresponding stillwater longitudinal strength.......Methods for the calculation of the lightweight of the ship.Loading conditions satisfying draught, trim and intact stability requirements and analysis of the corresponding stillwater longitudinal strength....

  7. Specific language impairment as a maturational lag: evidence from longitudinal data on language and motor development.

    Science.gov (United States)

    Bishop, D V; Edmundson, A

    1987-08-01

    Longitudinal language-test data on 87 language-impaired children assessed at the ages of four, 4 1/2 and 5 1/2 years were converted to age-equivalent scores to compare the rates of development of children who recover from early language delay with those who have more persisting problems. On most measures, over the 18-month period all the children progressed by about 18 months. Thus although children with good and poor outcomes were distinguished in terms of initial level of performance, they did not differ in rate of progress. Speed on a peg-moving task was closely related to language performance. Children who had a good outcome after early language delay had significantly impaired scores at four years, but subsequently were indistinguishable from a control group. Quantitative but not qualitative differences in peg-moving performance were found for children with good and poor outcomes. No association was found between presumptive aetiological factors and language or pegboard performance. These findings are interpreted in terms of a theory which attributes specific language impairment to a maturational lag in neurological development.

  8. Longitudinal Diagnostics for Short Electron Beam Bunches

    Energy Technology Data Exchange (ETDEWEB)

    Loos, H.; /SLAC

    2010-06-11

    Single-pass free electron lasers require high peak currents from ultra-short electron bunches to reach saturation and an accurate measurement of bunch length and longitudinal bunch profile is necessary to control the bunch compression process from low to high beam energy. The various state-of-the-art diagnostics methods from ps to fs time scales using coherent radiation detection, RF deflection, and other techniques are presented. The use of linear accelerators as drivers for free electron lasers (FEL) and the advent of single-pass (SASE) FELs has driven the development of a wide range of diagnostic techniques for measuring the length and longitudinal distribution of short and ultra-short electron bunches. For SASE FELs the radiation power and the length of the undulator needed to achieve saturation depend strongly on the charge density of the electron beam. In the case of X-ray FELs, this requires the accelerator to produce ultra-high brightness beams with micron size transverse normalized emittances and peak currents of several kA through several stages of magnetic bunch compression. Different longitudinal diagnostics are employed to measure the peak current and bunch profile along these stages. The measurement techniques can be distinguished into different classes. Coherent methods detect the light emitted from the beam by some coherent radiation process (spectroscopic measurement), or directly measure the Coulomb field traveling with the beam (electro-optic). Phase space manipulation techniques map the time coordinate onto a transverse dimension and then use conventional transverse beam diagnostics (transverse deflector, rf zero-phasing). Further methods measure the profile or duration of an incoherent light pulse emitted by the bunch at wavelengths much shorted than the bunch length (streak camera, fluctuation technique) or modulate the electron beam at an optical wavelength and then generate a narrow bandwidth radiation pulse with the longitudinal profile of

  9. Longitudinal Profiles of Adaptive Behavior in Fragile X Syndrome

    Science.gov (United States)

    Quintin, Eve-Marie; Jo, Booil; Lightbody, Amy A.; Hazlett, Heather Cody; Piven, Joseph; Hall, Scott S.; Reiss, Allan L.

    2014-01-01

    OBJECTIVE: To examine longitudinally the adaptive behavior patterns in fragile X syndrome. METHOD: Caregivers of 275 children and adolescents with fragile X syndrome and 225 typically developing children and adolescents (2–18 years) were interviewed with the Vineland Adaptive Behavior Scales every 2 to 4 years as part of a prospective longitudinal study. RESULTS: Standard scores of adaptive behavior in people with fragile X syndrome are marked by a significant decline over time in all domains for males and in communication for females. Socialization skills are a relative strength as compared with the other domains for males with fragile X syndrome. Females with fragile X syndrome did not show a discernible pattern of developmental strengths and weaknesses. CONCLUSIONS: This is the first large-scale longitudinal study to show that the acquisition of adaptive behavior slows as individuals with fragile X syndrome age. It is imperative to ensure that assessments of adaptive behavior skills are part of intervention programs focusing on childhood and adolescence in this condition. PMID:25070318

  10. Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial Development

    Czech Academy of Sciences Publication Activity Database

    Celá, Petra; Hampl, Marek; Shylo, N.; Christopher, K. J.; Kavková, M.; Landová, Marie; Zikmund, T.; Weatherbee, S. D.; Kaiser, J.; Buchtová, Marcela

    2018-01-01

    Roč. 97, č. 1 (2018), s. 108-117 ISSN 0022-0345 R&D Projects: GA ČR(CZ) GB14-37368G; GA MŠk EF15_003/0000460 Institutional support: RVO:67985904 Keywords : craniofacial anomalies * growth/development * mineralized tissue/development * orofacial clefts * cell signaling Subject RIV: EA - Cell Biology Impact factor: 4.755, year: 2016

  11. Searching for gluon number fluctuations effects in eA collisions

    Energy Technology Data Exchange (ETDEWEB)

    Kugeratski, M. S. [Universidade Federal de Santa Catarina, Campus Joinville, Rua Presidente Prudente de Moraes, 406, CEP 89218-000, Joinville, SC (Brazil); Gonçalves, V. P.; Santana Amaral, J. T. de [Instituto de Física e Matemática, Universidade Federal de Pelotas, Caixa Postal 354, CEP 96010-900, Pelotas, RS (Brazil)

    2014-11-11

    We propose to investigate the gluon number fluctuations effects in deep inelastic electron-ion scattering at high energies. We estimate the nuclear structure function F{sub 2}{sup A}(x,Q{sup 2}), as well the longitudinal and charm contributions, using a generalization for nuclear targets of the Golec-Biernat-Wusthoff (GBW) model which describes the electron proton HERA data. Here we consider that the nucleus at high energies acts as an amplifier of the physics of high parton densities. For a first investigation we study the scattering with Ca and Pb nuclei. Our preliminary results predict that the effects of gluon number fluctuations are small in the region of the future electron ion collider.

  12. Longitudinal research and data collection in primary care.

    NARCIS (Netherlands)

    Weel, C. van

    2005-01-01

    PURPOSE: This article reviews examples of and experience with longitudinal research in family medicine. The objective is to use this empirical information to formulate recommendations for improving longitudinal research. METHODS: The article discusses 3 longitudinal studies from the Nijmegen

  13. Stability and change in adult personality over 6 years: findings from the Victoria Longitudinal Study.

    Science.gov (United States)

    Small, Brent J; Hertzog, Christopher; Hultsch, David F; Dixon, Roger A

    2003-05-01

    Data from the Victoria Longitudinal Study were used to examine the 6-year longitudinal stability of personality in older adults. Personality was measured with the NEO Personality Inventory. The longitudinal sample consisted of 223 adults initially ranging from 55 to 85 years of age. Longitudinal confirmatory factor analyses were used to examine the stability of individual differences in change over time, and the stability of the longitudinal factor structure. The results indicated both substantial stability at the level of individual differences in change, as well as significant individual differences in change that were related to age and gender. Finally, the factor structure of personality was invariant over time but did not approximate simple structure for the five dimensions of personality. Our study of 6-year personality development provided both (a). a confirmation of early significant stability findings and (b). unique evidence for significant individual differences in late adulthood.

  14. Revisiting the Dedifferentiation Hypothesis with Longitudinal Multi-Cohort Data

    Science.gov (United States)

    de Frias, Cindy M.; Lovden, Martin; Lindenberger, Ulman; Nilsson, Lars-Goran

    2007-01-01

    The present longitudinal multi-cohort study examines whether interindividual variability in cognitive performance and change increases in old age, and whether associations among developments of different cognitive functions increase with adult age. Multivariate multiple-group latent growth modeling was applied to data from narrow cohorts separated…

  15. Longitudinal Bidirectional Relations between Adolescents' Sympathy and Prosocial Behavior

    Science.gov (United States)

    Carlo, Gustavo; Padilla-Walker, Laura M.; Nielson, Matthew G.

    2015-01-01

    Despite the importance of understanding sympathy and prosocial behaviors, research on the development of these tendencies in adolescence remains relatively sparse. In the present study, we examined age trends and bidirectional longitudinal relations in sympathy and prosocial behaviors across early to middle adolescents. Participants were 500…

  16. Correlations of light particles in the reaction 40Ar on 197Au at E/A=200 MeV

    International Nuclear Information System (INIS)

    Kunde, G.J.

    1990-08-01

    For the study of small-angle correlations of light particles an experiment at the SATURNE synchrotron with 40 Ar on 197 Au at an incident energy of E/A=200 MeV was performed. A hodoscope consisting of an 8x8 matrix of silicon-cesium iodide detectors was applied under a mean angle of 40 degrees. The evaluation of the coincident particle information was performed via correlation functions, which were determined for systems with Z ≤ = 3. For three different fragments emission temperatures were measured via the determination of population ratios for particle-unstable states. Furthermore by means of p-p correlations the reaction volume was studied. The results are: For 5 Li a mean emission temperature of 6.4 -1.0 1.1 MeV resulted, for 4 He a mean emission temperature of 5.4 -1.2 +1.8 MeV was found. The temperature of 2.3 -0.2 0.6 MeV determined for 8 Be is strongly influenced by feeding. For the states at 21.1 and 22.1 MeV in 4 He a dependence of the temperature on the kinetic sum energy of the coincident particles was found, a temperature growth with increasing sum energy of about 3 MeV over the measured range of the sum energies resulted. Via p-p correlations a source radius of 5.8 ± 0.3 fm was determined. The correction for protons from sequential decays leads to radii, which are about 1 fm smaller. The radii and radius ratios for different ranges of the sum energy of the protons were analyzed. The measured emission temperatures are about 1 MeV higher than the values for the same system at E/A = 60 MeV. The temperatures correspond in the model of the statistical multifragmentation to an excitation energy of about 2 GeV, while they follow in the model of the sequential fragment emission for an excitation energy of about 1 GeV. (orig.) [de

  17. Longitudinal Alterations of Frontoparietal and Frontotemporal Networks Predict Future Creative Cognitive Ability.

    Science.gov (United States)

    Chen, Qunlin; Beaty, Roger E; Wei, Dongtao; Yang, Junyi; Sun, Jiangzhou; Liu, Wei; Yang, Wenjing; Zhang, Qinglin; Qiu, Jiang

    2018-01-01

    Creative cognition is important to academic performance and career success during late adolescence and adulthood. However, there is a lack of longitudinal data on whether brain structural development could predict improvements in creative thinking, and how such changes interact with other cognitive abilities to support creative performance. Here we examined longitudinal alterations of brain structure and their relation to creative cognitive ability in a sample of 159 healthy young adults who were scanned using magnetic resonance imaging 2-3 times over the course of 3 years. The most robust predictor of future creative ability was the right dorsolateral prefrontal cortex (DLPFC), which in conjunction with baseline creative capacity showed a 31% prediction rate. Longitudinal analysis revealed that slower decreases in gray matter density within left frontoparietal and right frontotemporal clusters predicted enhanced creative ability. Moreoever, the relationship between longitudinal alterations within frontal-related clusters and improved creative ability was moderated by the right DLPFC and working memory ability. We conclude that continuous goal-directed planning and accumulated knowledge are implemented in the right DLPFC and temporal areas, respectively, which in turn support longitudinal gains in creative cognitive ability. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  18. A longitudinal multilevel CFA-MTMM model for interchangeable and structurally different methods

    Science.gov (United States)

    Koch, Tobias; Schultze, Martin; Eid, Michael; Geiser, Christian

    2014-01-01

    One of the key interests in the social sciences is the investigation of change and stability of a given attribute. Although numerous models have been proposed in the past for analyzing longitudinal data including multilevel and/or latent variable modeling approaches, only few modeling approaches have been developed for studying the construct validity in longitudinal multitrait-multimethod (MTMM) measurement designs. The aim of the present study was to extend the spectrum of current longitudinal modeling approaches for MTMM analysis. Specifically, a new longitudinal multilevel CFA-MTMM model for measurement designs with structurally different and interchangeable methods (called Latent-State-Combination-Of-Methods model, LS-COM) is presented. Interchangeable methods are methods that are randomly sampled from a set of equivalent methods (e.g., multiple student ratings for teaching quality), whereas structurally different methods are methods that cannot be easily replaced by one another (e.g., teacher, self-ratings, principle ratings). Results of a simulation study indicate that the parameters and standard errors in the LS-COM model are well recovered even in conditions with only five observations per estimated model parameter. The advantages and limitations of the LS-COM model relative to other longitudinal MTMM modeling approaches are discussed. PMID:24860515

  19. Predicting longitudinal trajectories of health probabilities with random-effects multinomial logit regression.

    Science.gov (United States)

    Liu, Xian; Engel, Charles C

    2012-12-20

    Researchers often encounter longitudinal health data characterized with three or more ordinal or nominal categories. Random-effects multinomial logit models are generally applied to account for potential lack of independence inherent in such clustered data. When parameter estimates are used to describe longitudinal processes, however, random effects, both between and within individuals, need to be retransformed for correctly predicting outcome probabilities. This study attempts to go beyond existing work by developing a retransformation method that derives longitudinal growth trajectories of unbiased health probabilities. We estimated variances of the predicted probabilities by using the delta method. Additionally, we transformed the covariates' regression coefficients on the multinomial logit function, not substantively meaningful, to the conditional effects on the predicted probabilities. The empirical illustration uses the longitudinal data from the Asset and Health Dynamics among the Oldest Old. Our analysis compared three sets of the predicted probabilities of three health states at six time points, obtained from, respectively, the retransformation method, the best linear unbiased prediction, and the fixed-effects approach. The results demonstrate that neglect of retransforming random errors in the random-effects multinomial logit model results in severely biased longitudinal trajectories of health probabilities as well as overestimated effects of covariates on the probabilities. Copyright © 2012 John Wiley & Sons, Ltd.

  20. Decay patterns of target-like and projectile-like nuclei in 84Kr+197Au, natU reactions at E/A=150 MeV

    International Nuclear Information System (INIS)

    Quednau, B.M.; Galin, J.; Ledoux, X.; Crema, E.; Gebauer, B.; Hilscher, D.; Jahnke, U.; Jacquet, D.; Leray, S.; and others.

    1996-01-01

    The reactions 84 Kr+ 197 Au and 84 Kr+ nat U were studied at E/A=150 MeV employing the large-volume neutron multiplicity filter ORION at SATURNE. The observed correlations between the atomic number of projectile-like nuclei and neutron multiplicity indicate large excitation energies in the primary projectile- and target-like fragments. Angular correlations between the fission fragments of the U-like nucleus and the projectile-like fragments show a memory of the reaction plane, however no indications of spin effects are found. (author)

  1. Influence of combined impact and cyclic loading on the overall fatigue life of forged steel, EA4T

    Energy Technology Data Exchange (ETDEWEB)

    Malekzadeh, A.; Hadidi-Moud, S.; Farhangdoost, Kh [Ferdowsi University of Mashhad, Mashhad (Iran, Islamic Republic of)

    2017-03-15

    The performance of forged steel, EA4T, used in rail industry, under simulated in service conditions, i.e. combined impact - cyclic loading, was investigated through a comprehensive experimental programme. The standard Paris-Erdogan fatigue design curve parameters, m and C, were calibrated to account for the effect of the impact component of loading. A minimum threshold for impact load component, identified in the experiments, was also incorporated in the proposed empirical model. Comparison with experimental findings indicated that this “modified” Fatigue design curve could predict the fatigue life of pre impact loaded specimens with sufficient accuracy. It was therefore suggested that the modified model may be used as a novel design tool for predicting the overall fatigue life of components made of this material under the specified combined impact and fatigue loading conditions.

  2. Does age at the time of elective cardiac surgery or catheter intervention in children influence the longitudinal development of psychological distress and styles of coping of parents?

    NARCIS (Netherlands)

    Utens, Elisabeth M.; Versluis-den Bieman, Herma J.; Witsenburg, Maarten; Bogers, Ad J. J. C.; Hess, John; Verhulst, Frank C.

    2002-01-01

    To assess the influence of age at a cardiac procedure of children, who underwent elective cardiac surgery or interventional cardiac catheterisation for treatment of congenital cardiac defects between 3 months and 7 years of age, on the longitudinal development of psychological distress and styles of

  3. Personality factors and breast cancer development: a prospective longitudinal study.

    Science.gov (United States)

    Bleiker, E M; van der Ploeg, H M; Hendriks, J H; Adèr, H J

    1996-10-16

    It has been estimated that approximately 25% of all breast cancers in women can be explained by currently recognized somatic (i.e., hereditary and physiologic) risk factors. It has also been hypothesized that psychological factors may play a role in the development of breast cancer. We investigated the extent to which personality factors, in addition to somatic risk factors, may be associated with the development of primary breast cancer. We employed a prospective, longitudinal study design. From 1989 through 1990, a personality questionnaire was sent to all female residents of the Dutch city of Nijmegen who were 43 years of age or older. This questionnaire was sent as part of an invitation to participate in a population-based breast cancer screening program. Women who developed breast cancer among those who returned completed questionnaires were compared with women without such a diagnosis in regard to somatic risk factors and personality traits, including anxiety, anger, depression, rationality, anti-emotionality (i.e., an absence of emotional behavior or a lack of trust in one's own feelings), understanding, optimism, social support, and the expression and control of emotions. Conditional logistic regression analysis was used to identify variables that could best explain group membership (i.e., belonging to the case [breast cancer] or the control [without disease] group). Personality questionnaires were sent to 28 940 women, and 9705 (34%) were returned in such a way that they could be used for statistical analyses. Among the 9705 women who returned useable questionnaires, 131 were diagnosed with breast cancer during the period from 1989 through 1994. Seven hundred seventy-one age-matched control subjects (up to six per case patient) were selected for the analyses. Three variables were found to be statistically significantly associated with an increased risk of breast cancer: 1) having a first-degree family member with breast cancer (versus not having an

  4. 46 CFR 154.176 - Longitudinal contiguous hull structure.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Longitudinal contiguous hull structure. 154.176 Section... Equipment Hull Structure § 154.176 Longitudinal contiguous hull structure. (a) The longitudinal contiguous hull structure of a vessel having cargo containment systems without secondary barriers must meet the...

  5. Development of numerical processing in children with typical and dyscalculic arithmetic skills – a longitudinal study

    Directory of Open Access Journals (Sweden)

    Karin eLanderl

    2013-07-01

    Full Text Available Numerical processing has been demonstrated to be closely associated with arithmetic skills, however, our knowledge on the development of the relevant cognitive mechanisms is limited. The present longitudinal study investigated the developmental trajectories of numerical processing in 42 children with age-adequate arithmetic development and 41 children with dyscalculia over a two-year period from beginning of Grade 2, when children were 7;6 years old, to beginning of Grade 4. A battery of numerical processing tasks (dot enumeration, non-symbolic and symbolic comparison of one- and two-digit numbers, physical comparison, number line estimation was given five times during the study (beginning and middle of each school year. Efficiency of numerical processing was a very good indicator of development in numerical processing while within-task effects remained largely constant and showed low long-term stability before middle of Grade 3. Children with dyscalculia showed less efficient numerical processing reflected in specifically prolonged response times. Importantly, they showed consistently larger slopes for dot enumeration in the subitizing range, an untypically large compatibility effect when processing two-digit numbers, and they were consistently less accurate in placing numbers on a number line. Thus, we were able to identify parameters that can be used in future research to characterize numerical processing in typical and dyscalculic development. These parameters can also be helpful for identification of children who struggle in their numerical development.

  6. Development of the Ethmoidal Structures of the Endocranium in Discoglossus pictus (Anura: Discoglossidae)

    Czech Academy of Sciences Publication Activity Database

    Královec, K.; Roček, Zbyněk; Žáková, P.; Mužáková, V.

    2010-01-01

    Roč. 271, č. 9 (2010), s. 1078-1093 ISSN 0362-2525 Institutional research plan: CEZ:AV0Z30130516 Keywords : Anura * Discoglossidae * Discoglossus * development * cranium Subject RIV: EA - Cell Biology Impact factor: 1.773, year: 2010

  7. Longitudinal vocabulary development in Australian urban Aboriginal children: Protective and risk factors.

    Science.gov (United States)

    Short, K; Eadie, P; Descallar, J; Comino, E; Kemp, L

    2017-11-01

    Vocabulary is a key component of language that can impact on children's future literacy and communication. The gap between Australian Aboriginal and non-Aboriginal children's reading and academic outcomes is well reported and similar to Indigenous/non-Indigenous gaps in other nations. Determining factors that influence vocabulary acquisition over time and may be responsive to treatment is important for improving Aboriginal children's communication and academic outcomes. To determine what factors influence Australian urban Aboriginal children's receptive vocabulary acquisition and whether any of these are risks or protective for vocabulary development. One hundred thirteen Aboriginal children in South Western Sydney from the longitudinal birth cohort Gudaga study were assessed on The Peabody Picture Vocabulary Test multiple times: 3 years, just prior to school entry, at the end of the first and second years of formal schooling. Multilevel models were used to determine the effects of 13 fixed and manipulable maternal, child, and family variables drawn from previous research. Higher maternal education was found to be protective at 3 years and over time. The number of children in urban Australian Aboriginal households made an impact on vocabulary development and this varied over time. From 3 to 6 years, those with early poor non-verbal cognitive skills had vocabulary skills that remained below those with stronger non-verbal skills at 3 years. Girls exhibit an earlier advantage in vocabulary acquisition, but this difference is not sustained after 4 years of age. The risk and protective factors for vocabulary development in Australian Aboriginal children are similar to those identified in other studies with some variation related to the number of children in the home. In this limited set of predictors, maternal education, gender, non-verbal cognitive skills, and the number of children in households were all shown to impact on the acquisition of vocabulary to 3

  8. Sample size determination for mediation analysis of longitudinal data.

    Science.gov (United States)

    Pan, Haitao; Liu, Suyu; Miao, Danmin; Yuan, Ying

    2018-03-27

    Sample size planning for longitudinal data is crucial when designing mediation studies because sufficient statistical power is not only required in grant applications and peer-reviewed publications, but is essential to reliable research results. However, sample size determination is not straightforward for mediation analysis of longitudinal design. To facilitate planning the sample size for longitudinal mediation studies with a multilevel mediation model, this article provides the sample size required to achieve 80% power by simulations under various sizes of the mediation effect, within-subject correlations and numbers of repeated measures. The sample size calculation is based on three commonly used mediation tests: Sobel's method, distribution of product method and the bootstrap method. Among the three methods of testing the mediation effects, Sobel's method required the largest sample size to achieve 80% power. Bootstrapping and the distribution of the product method performed similarly and were more powerful than Sobel's method, as reflected by the relatively smaller sample sizes. For all three methods, the sample size required to achieve 80% power depended on the value of the ICC (i.e., within-subject correlation). A larger value of ICC typically required a larger sample size to achieve 80% power. Simulation results also illustrated the advantage of the longitudinal study design. The sample size tables for most encountered scenarios in practice have also been published for convenient use. Extensive simulations study showed that the distribution of the product method and bootstrapping method have superior performance to the Sobel's method, but the product method was recommended to use in practice in terms of less computation time load compared to the bootstrapping method. A R package has been developed for the product method of sample size determination in mediation longitudinal study design.

  9. Total Survey Error for Longitudinal Surveys

    NARCIS (Netherlands)

    Lynn, Peter; Lugtig, P.J.

    2016-01-01

    This article describes the application of the total survey error paradigm to longitudinal surveys. Several aspects of survey error, and of the interactions between different types of error, are distinct in the longitudinal survey context. Furthermore, error trade-off decisions in survey design and

  10. Tomographic Measurements of Longitudinal Phase Space Density

    CERN Document Server

    Hancock, S; McIntosh, E; Metcalf, M

    1999-01-01

    Tomography : the reconstruction of a two-dimensional image from a series of its one-dimensional projections is now a very broad topic with a wealth of algorithms for the reconstruction of both qualitative and quantitative images. One of the simplest algorithms has been modified to take into account the non-linearity of large-amplitude synchrotron motion in a particle accelerator. This permits the accurate reconstruction of longitudinal phase space density from one-dimensional bunch profile data. The algorithm was developed in Mathematica TM in order to exploit the extensive built-in functions and graphics. Subsequently, it has been recoded in Fortran 90 with the aim of reducing the execution time by at least a factor of one hundred. The choice of Fortran 90 was governed by the desire ultimately to exploit parallel architectures, but sequential compilation and execution have already largely yielded the required gain in speed. The use of the method to produce longitudinal phase space plots, animated sequences o...

  11. Longitudinal development of subtraction performance in elementary school.

    Science.gov (United States)

    Artemenko, Christina; Pixner, Silvia; Moeller, Korbinian; Nuerk, Hans-Christoph

    2017-10-05

    A major goal of education in elementary mathematics is the mastery of arithmetic operations. However, research on subtraction is rather scarce, probably because subtraction is often implicitly assumed to be cognitively similar to addition, its mathematical inverse. To evaluate this assumption, we examined the relation between the borrow effect in subtraction and the carry effect in addition, and the developmental trajectory of the borrow effect in children using a choice reaction paradigm in a longitudinal study. In contrast to the carry effect in adults, carry and borrow effects in children were found to be categorical rather than continuous. From grades 3 to 4, children became more proficient in two-digit subtraction in general, but not in performing the borrow operation in particular. Thus, we observed no specific developmental progress in place-value computation, but a general improvement in subtraction procedures. Statement of contribution What is already known on this subject? The borrow operation increases difficulty in two-digit subtraction in adults. The carry effect in addition, as the inverse operation of borrowing, comprises categorical and continuous processing characteristics. What does this study add? In contrast to the carry effect in adults, the borrow and carry effects are categorical in elementary school children. Children generally improve in subtraction performance from grades 3 to 4 but do not progress in place-value computation in particular. © 2017 The British Psychological Society.

  12. Evaluating the effectiveness of British Columbia's environmental assessment process for first nations' participation in mining development

    International Nuclear Information System (INIS)

    Baker, Douglas C.; McLelland, James N.

    2003-01-01

    This paper applies effectiveness as a criterion to measure the participation of First Nations' participation in British Columbia's environmental assessment process. Effectiveness is reviewed as a means to measure policy implementation and an expanded framework is proposed to measure effectiveness. The framework is applied to three case studies in north-central British Columbia to measure the effectiveness of First Nations' participation in the EA process for mining development. All three cases failed to achieve procedural, substantive, and transactive efficacy and thereby failed to meet overall policy effectiveness. The policies used by the British Columbia government, including the relatively recent Environmental Assessment Act (1995), reflect a poor integration of First Nations people in the EA decision-making process with respect to mine development

  13. STATISTICAL GROWTH MODELING OF LONGITUDINAL DT-MRI FOR REGIONAL CHARACTERIZATION OF EARLY BRAIN DEVELOPMENT.

    Science.gov (United States)

    Sadeghi, Neda; Prastawa, Marcel; Fletcher, P Thomas; Gilmore, John H; Lin, Weili; Gerig, Guido

    2012-01-01

    A population growth model that represents the growth trajectories of individual subjects is critical to study and understand neurodevelopment. This paper presents a framework for jointly estimating and modeling individual and population growth trajectories, and determining significant regional differences in growth pattern characteristics applied to longitudinal neuroimaging data. We use non-linear mixed effect modeling where temporal change is modeled by the Gompertz function. The Gompertz function uses intuitive parameters related to delay, rate of change, and expected asymptotic value; all descriptive measures which can answer clinical questions related to growth. Our proposed framework combines nonlinear modeling of individual trajectories, population analysis, and testing for regional differences. We apply this framework to the study of early maturation in white matter regions as measured with diffusion tensor imaging (DTI). Regional differences between anatomical regions of interest that are known to mature differently are analyzed and quantified. Experiments with image data from a large ongoing clinical study show that our framework provides descriptive, quantitative information on growth trajectories that can be directly interpreted by clinicians. To our knowledge, this is the first longitudinal analysis of growth functions to explain the trajectory of early brain maturation as it is represented in DTI.

  14. Internato Longitudinal

    Directory of Open Access Journals (Sweden)

    Marcelo Marcos Piva Demarzo

    Full Text Available O internato médico tem gerado recorrente debate frente às transformações curriculares em andamento no País. A despeito das discussões, um modelo de internato consonante com essas mudanças ainda não foi consistentemente delineado. Neste ensaio, trazemos uma proposta de matriz estruturante para o internato médico. Propomos que o internato médico seja realizado durante os seis anos do curso, de forma longitudinal, tendo como eixo estruturante a clínica da Atenção Básica (AB. Esse modelo de "internato longitudinal" prevê a introdução progressiva na prática clínica, iniciando-se pela AB nos dois primeiros anos, acrescentando-se progressivamente os ambulatórios de especialidades, os estágios hospitalares e demais atividades práticas, alcançando-se, dessa forma, o rol de diversidade e complexidade previsto para o egresso da escola médica.

  15. A new visualization and conceptualization of categorical longitudinal development: Measurement invariance and change

    Directory of Open Access Journals (Sweden)

    Jan eBoom

    2015-03-01

    Full Text Available The Overlapping Waves Model (OWM is a metaphor introduced by Siegler in 1996 to illustrate a typical sequence of increasing and decreasing use of strategies during development. Going beyond metaphor, a new model synthesized from Latent Growth Modeling (LGM and Item Response Theory (IRT will be presented to analyze such categorical longitudinal data. Use of strategies can be scored as a variable with only a few ordinal categories. IRT provides the means to relate the usage of strategies to position on an underlying developmental dimension. LGM allows to model movement of individuals along this dimension, acknowledging individual differences both in starting point and in speed of progress. Measuring and modeling such strategy development requires that at each time point the same categories are used, in the sense that item difficulties must remain invariant over time. Whether discrimination can be relaxed is still an issue. The problem that had to be solved was disentangling the between-person-individual differences from real intra-individual developmental differences. Figures with polytomous or multi-category Item Characteristic Curves (ICC's resemble the OWM in many respects. However, such figures are usually taken to represent inter-individual differences, whereas the OWM usually represents development (so intra-individual differences, and we cannot have both at the same time. The solution came from creating a framework with ability differences on one axis and the effect of time on another axis, resulting in a 3-D model. These (orthogonal dimensions make it possible to adequately conceptualize measurement invariance in this complex context.As the result is difficult to conceptualize without extensive visualization, special 3-D figures will be used to illustrate and a dynamic (rotatable and scalable version will be made available as Computable Document Format object (Mathematica. The model was successfully applied in several microgenetic studies.

  16. Summary of longitudinal instabilities workshop

    Energy Technology Data Exchange (ETDEWEB)

    Chasman, R.

    1976-01-01

    A five-day ISABELLE workshop on longitudinal instabilities was held at Brookhaven, August 9-13, 1976. About a dozen outside accelerator experts, both from Europe and the U.S.A., joined the local staff for discussions of longitudinal instabilities in ISABELLE. An agenda of talks was scheduled for the first day of the workshop. Later during the week, a presentation was given on the subject ''A more rigorous treatment of Landau damping in longitudinal beam instabilities''. A few progress meetings were held in which disagreements regarding calculations of coupling impedances were clarified. A summary session was held on the last day. Heavy emphasis was put on single bunched beam instabilities in the microwave region extending above the cut-off frequency of the ISABELLE vacuum chamber.

  17. High-frequency electroacupuncture versus carprofen in an incisional pain model in rats

    Directory of Open Access Journals (Sweden)

    F.M. Teixeira

    2012-12-01

    Full Text Available The objective of the present study was to compare the effect of electroacupuncture (EA and carprofen (CP on postoperative incisional pain using the plantar incision (PI model in rats. A 1-cm longitudinal incision was made through skin, fascia and muscles of a hind paw of male Wistar rats and the development of mechanical and thermal hypersensitivity was determined over 4 days using the von Frey and Hargreaves methods, respectively. Based on the experimental treatments received on the third postoperative day, the animals were divided into the following groups: PI+CP (CP, 2 mg/kg, po; PI+EAST36 (100-Hz EA applied bilaterally at the Zusanli point (ST36; PI+EANP (EA applied to a non-acupoint region; PI+IMMO (immobilization only; PI (vehicle. In the von Frey test, the PI+EAST36 group had higher withdrawal force thresholds in response to mechanical stimuli than the PI, PI+IMMO and PI+EANP groups at several times studied. Furthermore, the PI+EAST36 group showed paw withdrawal thresholds in response to mechanical stimuli that were similar to those of the PI+CP group. In the Hargreaves test, all groups had latencies higher than those observed with PI. The PI+EAST36 group was similar to the PI+IMMO, PI+EANP and PI+CP groups. We conclude that 100-Hz EA at the ST36 point, but not at non-acupoints, can reduce mechanical nociception in the rat model of incisional pain, and its effectiveness is comparable to that of carprofen.

  18. High-frequency electroacupuncture versus carprofen in an incisional pain model in rats

    International Nuclear Information System (INIS)

    Teixeira, F.M.; Castro, L.L.; Ferreira, R.T.; Pires, P.A.; Vanderlinde, F.A.; Medeiros, M.A.

    2012-01-01

    The objective of the present study was to compare the effect of electroacupuncture (EA) and carprofen (CP) on postoperative incisional pain using the plantar incision (PI) model in rats. A 1-cm longitudinal incision was made through skin, fascia and muscles of a hind paw of male Wistar rats and the development of mechanical and thermal hypersensitivity was determined over 4 days using the von Frey and Hargreaves methods, respectively. Based on the experimental treatments received on the third postoperative day, the animals were divided into the following groups: PI+CP (CP, 2 mg/kg, po); PI+EAST36 (100-Hz EA applied bilaterally at the Zusanli point (ST36)); PI+EANP (EA applied to a non-acupoint region); PI+IMMO (immobilization only); PI (vehicle). In the von Frey test, the PI+EAST36 group had higher withdrawal force thresholds in response to mechanical stimuli than the PI, PI+IMMO and PI+EANP groups at several times studied. Furthermore, the PI+EAST36 group showed paw withdrawal thresholds in response to mechanical stimuli that were similar to those of the PI+CP group. In the Hargreaves test, all groups had latencies higher than those observed with PI. The PI+EAST36 group was similar to the PI+IMMO, PI+EANP and PI+CP groups. We conclude that 100-Hz EA at the ST36 point, but not at non-acupoints, can reduce mechanical nociception in the rat model of incisional pain, and its effectiveness is comparable to that of carprofen

  19. High-frequency electroacupuncture versus carprofen in an incisional pain model in rats.

    Science.gov (United States)

    Teixeira, F M; Castro, L L; Ferreira, R T; Pires, P A; Vanderlinde, F A; Medeiros, M A

    2012-12-01

    The objective of the present study was to compare the effect of electroacupuncture (EA) and carprofen (CP) on postoperative incisional pain using the plantar incision (PI) model in rats. A 1-cm longitudinal incision was made through skin, fascia and muscles of a hind paw of male Wistar rats and the development of mechanical and thermal hypersensitivity was determined over 4 days using the von Frey and Hargreaves methods, respectively. Based on the experimental treatments received on the third postoperative day, the animals were divided into the following groups: PI+CP (CP, 2 mg/kg, po); PI+EAST36 (100-Hz EA applied bilaterally at the Zusanli point (ST36)); PI+EANP (EA applied to a non-acupoint region); PI+IMMO (immobilization only); PI (vehicle). In the von Frey test, the PI+EAST36 group had higher withdrawal force thresholds in response to mechanical stimuli than the PI, PI+IMMO and PI+EANP groups at several times studied. Furthermore, the PI+EAST36 group showed paw withdrawal thresholds in response to mechanical stimuli that were similar to those of the PI+CP group. In the Hargreaves test, all groups had latencies higher than those observed with PI. The PI+EAST36 group was similar to the PI+IMMO, PI+EANP and PI+CP groups. We conclude that 100-Hz EA at the ST36 point, but not at non-acupoints, can reduce mechanical nociception in the rat model of incisional pain, and its effectiveness is comparable to that of carprofen.

  20. High-frequency electroacupuncture versus carprofen in an incisional pain model in rats

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, F.M.; Castro, L.L.; Ferreira, R.T.; Pires, P.A.; Vanderlinde, F.A.; Medeiros, M.A. [Departamento de Ciências Fisiológicas, Universidade Federal Rural do Rio de Janeiro, Rio de Janeiro, RJ (Brazil)

    2012-08-24

    The objective of the present study was to compare the effect of electroacupuncture (EA) and carprofen (CP) on postoperative incisional pain using the plantar incision (PI) model in rats. A 1-cm longitudinal incision was made through skin, fascia and muscles of a hind paw of male Wistar rats and the development of mechanical and thermal hypersensitivity was determined over 4 days using the von Frey and Hargreaves methods, respectively. Based on the experimental treatments received on the third postoperative day, the animals were divided into the following groups: PI+CP (CP, 2 mg/kg, po); PI+EAST36 (100-Hz EA applied bilaterally at the Zusanli point (ST36)); PI+EANP (EA applied to a non-acupoint region); PI+IMMO (immobilization only); PI (vehicle). In the von Frey test, the PI+EAST36 group had higher withdrawal force thresholds in response to mechanical stimuli than the PI, PI+IMMO and PI+EANP groups at several times studied. Furthermore, the PI+EAST36 group showed paw withdrawal thresholds in response to mechanical stimuli that were similar to those of the PI+CP group. In the Hargreaves test, all groups had latencies higher than those observed with PI. The PI+EAST36 group was similar to the PI+IMMO, PI+EANP and PI+CP groups. We conclude that 100-Hz EA at the ST36 point, but not at non-acupoints, can reduce mechanical nociception in the rat model of incisional pain, and its effectiveness is comparable to that of carprofen.

  1. Keeping secrets from parents: Longitudinal associations of secrecy in adolescence

    NARCIS (Netherlands)

    Frijns, T.; Finkenauer, C.; Vermulst, A.A.; Engels, R.C.M.E.

    2005-01-01

    A 2-wave survey study among 1173 10-14-year-olds tested the longitudinal contribution of secrecy from parents to psychosocial and behavioral problems in adolescence. Additionally, it investigated a hypothesized contribution of secrecy from parents to adolescent development by examining its relation

  2. Effects of Team and Organizational Commitment--A Longitudinal Study

    Science.gov (United States)

    Neininger, Alexandra; Lehmann-Willenbrock, Nale; Kauffeld, Simone; Henschel, Angela

    2010-01-01

    Retention management, i.e., keeping qualified employees, is a top priority for contemporary organizations. Commitment, and especially team commitment, can be the key to mastering this challenge. There is a lack of longitudinal research concerning the development and the direction of the effects of team commitment over time. In a longitudinal…

  3. Talented football players' development of achievement motives, volitional components, and self-referential cognitions: A longitudinal study.

    Science.gov (United States)

    Feichtinger, Philip; Höner, Oliver

    2015-01-01

    Adolescence is regarded as a key developmental phase in the course of talented football players' careers. The present study focuses on early adolescent players' development of achievement motives, volitional components, and self-referential cognitions. Based on the multidimensional and dynamic nature of talent, the development of multifaceted personality characteristics is an important issue in the context of sports talent research. According to previous findings in psychology, personality characteristics' development is defined by both stability and change, and the current study analyses four different types: differential stability (I), mean-level change (II), individual-level change (III), and structural stability (IV). The sample consists of 151 male players in the talent development programme of the German Football Association. Psychological diagnostics of the personality characteristics are implemented across longitudinal sections over a time period of three seasons, from the U12 to U14 age classes. The results reveal that the personality characteristics show (I) moderate test-retest correlations over one-year intervals (.43 ≤ rtt ≤ .62), and lower coefficients for a two-year period (.26 ≤ rtt ≤ .53). (II) Most of the personality characteristics' mean values differ significantly across the age classes with small effect sizes (.01 ≤ [Formula: see text] ≤ .03). (III) Only minor individual-level changes in the football players' development are found. (IV) The personality characteristics' associations within a two-factor structure do not stay invariant over time. From the results of the present study, conclusions are drawn regarding the talent identification and development process.

  4. δ15N measurement of organic and inorganic substances by EA-IRMS: a speciation-dependent procedure.

    Science.gov (United States)

    Gentile, Natacha; Rossi, Michel J; Delémont, Olivier; Siegwolf, Rolf T W

    2013-01-01

    Little attention has been paid so far to the influence of the chemical nature of the substance when measuring δ(15)N by elemental analysis (EA)-isotope ratio mass spectrometry (IRMS). Although the bulk nitrogen isotope analysis of organic material is not to be questioned, literature from different disciplines using IRMS provides hints that the quantitative conversion of nitrate into nitrogen presents difficulties. We observed abnormal series of δ(15)N values of laboratory standards and nitrates. These unexpected results were shown to be related to the tailing of the nitrogen peak of nitrate-containing compounds. A series of experiments were set up to investigate the cause of this phenomenon, using ammonium nitrate (NH(4)NO(3)) and potassium nitrate (KNO(3)) samples, two organic laboratory standards as well as the international secondary reference materials IAEA-N1, IAEA-N2-two ammonium sulphates [(NH(4))(2)SO(4)]-and IAEA-NO-3, a potassium nitrate. In experiment 1, we used graphite and vanadium pentoxide (V(2)O(5)) as additives to observe if they could enhance the decomposition (combustion) of nitrates. In experiment 2, we tested another elemental analyser configuration including an additional section of reduced copper in order to see whether or not the tailing could originate from an incomplete reduction process. Finally, we modified several parameters of the method and observed their influence on the peak shape, δ(15)N value and nitrogen content in weight percent of nitrogen of the target substances. We found the best results using mere thermal decomposition in helium, under exclusion of any oxygen. We show that the analytical procedure used for organic samples should not be used for nitrates because of their different chemical nature. We present the best performance given one set of sample introduction parameters for the analysis of nitrates, as well as for the ammonium sulphate IAEA-N1 and IAEA-N2 reference materials. We discuss these results considering the

  5. Development of a two-beam high-current ion accelerator based on Doppler effect. Final report (1994)

    International Nuclear Information System (INIS)

    Ivanov, B.I.; Yegorov, A.M.

    1995-03-01

    This Final Report presents the results of work accomplished in accordance with the Scope of Work to the Purchase Order No 4596310. The amount of works includes the following items: 1. Start of the manufacture of the Experimental Accelerating Stand (EAS)-the section for proton acceleration from 5 MeV to 8 MeV, in which RF fields are excited by an electron beam at the anomalous Doppler effect. 2. Theoretical investigation and computer simulation of field excitation and ion acceleration in the EAS. Under item 1, the EAS manufacturing is begun. To present time, a pedestal for the EAS and a stainless steel vacuum chamber for RF resonator are made (length of the chamber is about 180 cm, diameter is about 40 cm). Besides, parts of the EAS resonator with the acceleration structure are manufactured, and its assembly is begun. Under item 2, it is realized three works: calculation of increment and frequency shift of the EAS resonator excited by electron beam, calculation of the solenoid for creation of magnetic field with required spatial distribution, and theoretical investigation and computer simulation of ion acceleration in the EAS. 14 figs., 16 refs

  6. Use of missing data methods in longitudinal studies: the persistence of bad practices in developmental psychology.

    Science.gov (United States)

    Jelicić, Helena; Phelps, Erin; Lerner, Richard M

    2009-07-01

    Developmental science rests on describing, explaining, and optimizing intraindividual changes and, hence, empirically requires longitudinal research. Problems of missing data arise in most longitudinal studies, thus creating challenges for interpreting the substance and structure of intraindividual change. Using a sample of reports of longitudinal studies obtained from three flagship developmental journals-Child Development, Developmental Psychology, and Journal of Research on Adolescence-we examined the number of longitudinal studies reporting missing data and the missing data techniques used. Of the 100 longitudinal studies sampled, 57 either reported having missing data or had discrepancies in sample sizes reported for different analyses. The majority of these studies (82%) used missing data techniques that are statistically problematic (either listwise deletion or pairwise deletion) and not among the methods recommended by statisticians (i.e., the direct maximum likelihood method and the multiple imputation method). Implications of these results for developmental theory and application, and the need for understanding the consequences of using statistically inappropriate missing data techniques with actual longitudinal data sets, are discussed.

  7. Preliminary Results Regarding the Present Morphometric Characters of Thermal Rudd, Scardinius racovitzai Müller 1958 from Pețea Spring Natural Reserve

    Directory of Open Access Journals (Sweden)

    Grigoraş Gabriela

    2015-12-01

    Full Text Available The precarious temperature regime, associated with the negative influence of other environmental and biotic factors, represents a major risk for the survival of the thermal rudd from the lake Ochiul Mare, located in the Pârâul Peţea natural reserve. Therefore, a complex morphometric and body geometry analysis was conducted on specimens collected in 2013 in order to define the variability of the present population. The relatively small sample size is due to legislative restrictions on collecting endangered species, so statistical methods of analysis were applied to increase confidence in the assertions.

  8. Preschool Phonological and Morphological Awareness As Longitudinal Predictors of Early Reading and Spelling Development in Greek.

    Science.gov (United States)

    Diamanti, Vassiliki; Mouzaki, Angeliki; Ralli, Asimina; Antoniou, Faye; Papaioannou, Sofia; Protopapas, Athanassios

    2017-01-01

    Different language skills are considered fundamental for successful reading and spelling acquisition. Extensive evidence has highlighted the central role of phonological awareness in early literacy experiences. However, many orthographic systems also require the contribution of morphological awareness. The goal of this study was to examine the morphological and phonological awareness skills of preschool children as longitudinal predictors of reading and spelling ability by the end of first grade, controlling for the effects of receptive and expressive vocabulary skills. At Time 1 preschool children from kindergartens in the Greek regions of Attika, Crete, Macedonia, and Thessaly were assessed on tasks tapping receptive and expressive vocabulary, phonological awareness (syllable and phoneme), and morphological awareness (inflectional and derivational). Tasks were administered through an Android application for mobile devices (tablets) featuring automatic application of ceiling rules. At Time 2 one year later the same children attending first grade were assessed on measures of word and pseudoword reading, text reading fluency, text reading comprehension, and spelling. Complete data from 104 children are available. Hierarchical linear regression and commonality analyses were conducted for each outcome variable. Reading accuracy for both words and pseudowords was predicted not only by phonological awareness, as expected, but also by morphological awareness, suggesting that understanding the functional role of word parts supports the developing phonology-orthography mappings. However, only phonological awareness predicted text reading fluency at this age. Longitudinal prediction of reading comprehension by both receptive vocabulary and morphological awareness was already evident at this age, as expected. Finally, spelling was predicted by preschool phonological awareness, as expected, as well as by morphological awareness, the contribution of which is expected to

  9. Preschool Phonological and Morphological Awareness As Longitudinal Predictors of Early Reading and Spelling Development in Greek

    Directory of Open Access Journals (Sweden)

    Vassiliki Diamanti

    2017-11-01

    Full Text Available Different language skills are considered fundamental for successful reading and spelling acquisition. Extensive evidence has highlighted the central role of phonological awareness in early literacy experiences. However, many orthographic systems also require the contribution of morphological awareness. The goal of this study was to examine the morphological and phonological awareness skills of preschool children as longitudinal predictors of reading and spelling ability by the end of first grade, controlling for the effects of receptive and expressive vocabulary skills. At Time 1 preschool children from kindergartens in the Greek regions of Attika, Crete, Macedonia, and Thessaly were assessed on tasks tapping receptive and expressive vocabulary, phonological awareness (syllable and phoneme, and morphological awareness (inflectional and derivational. Tasks were administered through an Android application for mobile devices (tablets featuring automatic application of ceiling rules. At Time 2 one year later the same children attending first grade were assessed on measures of word and pseudoword reading, text reading fluency, text reading comprehension, and spelling. Complete data from 104 children are available. Hierarchical linear regression and commonality analyses were conducted for each outcome variable. Reading accuracy for both words and pseudowords was predicted not only by phonological awareness, as expected, but also by morphological awareness, suggesting that understanding the functional role of word parts supports the developing phonology–orthography mappings. However, only phonological awareness predicted text reading fluency at this age. Longitudinal prediction of reading comprehension by both receptive vocabulary and morphological awareness was already evident at this age, as expected. Finally, spelling was predicted by preschool phonological awareness, as expected, as well as by morphological awareness, the contribution of which is

  10. Developing a Shuffled Complex-Self Adaptive Hybrid Evolution (SC-SAHEL) Framework for Water Resources Management and Water-Energy System Optimization

    Science.gov (United States)

    Rahnamay Naeini, M.; Sadegh, M.; AghaKouchak, A.; Hsu, K. L.; Sorooshian, S.; Yang, T.

    2017-12-01

    Meta-Heuristic optimization algorithms have gained a great deal of attention in a wide variety of fields. Simplicity and flexibility of these algorithms, along with their robustness, make them attractive tools for solving optimization problems. Different optimization methods, however, hold algorithm-specific strengths and limitations. Performance of each individual algorithm obeys the "No-Free-Lunch" theorem, which means a single algorithm cannot consistently outperform all possible optimization problems over a variety of problems. From users' perspective, it is a tedious process to compare, validate, and select the best-performing algorithm for a specific problem or a set of test cases. In this study, we introduce a new hybrid optimization framework, entitled Shuffled Complex-Self Adaptive Hybrid EvoLution (SC-SAHEL), which combines the strengths of different evolutionary algorithms (EAs) in a parallel computing scheme, and allows users to select the most suitable algorithm tailored to the problem at hand. The concept of SC-SAHEL is to execute different EAs as separate parallel search cores, and let all participating EAs to compete during the course of the search. The newly developed SC-SAHEL algorithm is designed to automatically select, the best performing algorithm for the given optimization problem. This algorithm is rigorously effective in finding the global optimum for several strenuous benchmark test functions, and computationally efficient as compared to individual EAs. We benchmark the proposed SC-SAHEL algorithm over 29 conceptual test functions, and two real-world case studies - one hydropower reservoir model and one hydrological model (SAC-SMA). Results show that the proposed framework outperforms individual EAs in an absolute majority of the test problems, and can provide competitive results to the fittest EA algorithm with more comprehensive information during the search. The proposed framework is also flexible for merging additional EAs, boundary

  11. Sex differences in the development of emotion circuitry in adolescents at risk for substance abuse: a longitudinal fMRI study.

    Science.gov (United States)

    Hardee, Jillian E; Cope, Lora M; Munier, Emily C; Welsh, Robert C; Zucker, Robert A; Heitzeg, Mary M

    2017-06-01

    There is substantial evidence for behavioral sex differences in risk trajectories for alcohol and substance use, with internalizing factors such as negative affectivity contributing more to female risk. Because the neural development of emotion circuitry varies between males and females across adolescence, it represents a potential mechanism by which underlying neurobiology contributes to risk for substance use. Longitudinal functional magnetic resonance imaging was conducted in males and females (n = 18 each) with a family history of alcohol use disorders starting at ages 8-13 years. Participants performed an affective word task during functional magnetic resonance imaging at 1- to 2-year intervals, covering the age range of 8.5-17.6 years (3-4 scans per participant). Significant age-related sex differences were found in the right amygdala and right precentral gyrus for the negative vs neutral word condition. Males showed a significant decrease in both amygdala and precentral gyrus activation with age, whereas the response in females persisted. The subjective experience of internalizing symptomatology significantly increased with age for females but not for males. Taken together, these results reveal sex differences in negative affect processing in at-risk adolescents, and offer longitudinal neural evidence for female substance use risk through internalizing pathways. © The Author (2017). Published by Oxford University Press.

  12. A retrospective analysis of real-world use of the eaTracker® My Goals website by adults from Ontario and Alberta, Canada

    Directory of Open Access Journals (Sweden)

    Jessica R. L. Lieffers

    2016-09-01

    Full Text Available Abstract Background Little is known about use of goal setting and tracking tools within online programs to support nutrition and physical activity behaviour change. In 2011, Dietitians of Canada added “My Goals,” a nutrition and physical activity behaviour goal setting and tracking tool to their free publicly available self-monitoring website (eaTracker® ( http://www.eaTracker.ca/ . My Goals allows users to: a set “ready-made” SMART (Specific, Measurable, Attainable, Realistic, Time-related goals (choice of n = 87 goals from n = 13 categories or “write your own” goals, and b track progress using the “My Goals Tracker.” The purpose of this study was to characterize: a My Goals user demographics, b types of goals set, and c My Goals Tracker use. Methods Anonymous data on all goals set using the My Goals feature from December 6/2012-April 28/2014 by users ≥19y from Ontario and Alberta, Canada were obtained. This dataset contained: anonymous self-reported user demographic data, user set goals, and My Goals Tracker use data. Write your own goals were categorized by topic and specificity. Data were summarized using descriptive statistics. Multivariate binary logistic regression was used to determine associations between user demographics and a goal topic areas and b My Goals Tracker use. Results Overall, n = 16,511 goal statements (75.4 % ready-made; 24.6 % write your own set by n = 8,067 adult users 19-85y (83.3 % female; mean age 41.1 ± 15.0y, mean BMI 28.8 ± 7.6kg/m2 were included for analysis. Overall, 33.1 % of ready-made goals were from the “Managing your Weight” category. Of write your own goal entries, 42.3 % were solely distal goals (most related to weight management; 38.6 % addressed nutrition behaviour change (16.6 % had unspecific general eating goals; 18.1 % addressed physical activity behaviour change (47.3 % had goals without information on exercise amount and type. Many write your own

  13. Esophageal atresia: long-term interdisciplinary follow-up

    Directory of Open Access Journals (Sweden)

    Lidia B. Giúdici

    2016-07-01

    Full Text Available Background: We provide protocolized interdisciplinary follow-up to babies born with Esophageal Atresia (EA. There are few reports in Argentina about follow-up of EA patients.Objective: To describe outcomes in follow-up of EA patients at 1, 3 and 6 years old and to compare outcomes at age 1 with those at age 6.Methods: Prospective, longitudinal, analytic study of the cohort of babies born with EA, admitted to the follow-up program from 11/01/03 to 10/31/14. Follow-up includes: growth (weight > 10th centile, WHO, neurology-psychomotor development, audiology, vision, genetic, mental health, surgical reintervention, phonostomatology, language, pulmonology, re-hospitalization for clinical causes, lost to follow-up. Outcomes were described at age 1, 3 and 6. We included all EA patients who had reached age 1 at the start of this study.Results: 27 babies were admitted; 30% had long-gap EA; 18% presented VACTERL association; 23 children met inclusion criteria. Genetics  was assessed in 18 newborns (78%; a chromosomal map was performed in 11 babies; 3 had an abnormal karyotype. Mental health: 5/14 of the assessed children showed problems. Phonostomatology: 11 newborns checked (6 required treatment, 4 recovered at age 1. Pulmonologist evaluated 18 babies (7 with recurrent wheezing, 6 with moderate tracheomalacia. Gastroenterology and endoscopy: 80% presented gastroesophageal reflux (GER grade 3-4, and 50% showed a pathologic pHmetry. Lost to follow-up: age 1, 2 (8%; age 3, 3 (17%; age 6, 3 (23%. Normal outcomes observed are the following. Age 1 – growth: 81%; neurologic-psychomotor developmental index (NPDI: 76%; audiology: 95%; vision: 85%; language: 62%; re-hospitalization for clinical causes: 38%; surgical reinterventions: 47%. Age 3 – growth: 78%; NPDI: 50%; audiology: 93%; vision: 93%; language: 43%; re-hospitalization: 35%; surgical reinterventions: 14%. Age 6 – growth: 50%; NPDI: 30%; audiology: 90%; vision: 40%; language: 50%; re

  14. Crush analysis of the foam-filled bitubal circular tube under oblique impact

    Science.gov (United States)

    Djamaluddin, F.; Abdullah, S.; Arrifin, A. K.; Nopiah, Z. M.

    2018-02-01

    This paper presents crashworthiness analysis of bitubal cylindrical tubes under different impact angular. The numerical solution of double cylindrical tubes are determined by finite element analysis (FEA). Moreover, the structure was impacted by mass block as impactor respect to longitudinal direction of the tubes. The model of structure was developed by non-linear ABAQUS sofware with variations of load angle and dimensions of tube. The outcome of this study is the respons parameters such as the peak crusing force (PCF), energy absorption (EA) and specific energy absorption (SEA), thus it can be expected this tube as the great energy absorber.

  15. Study of CSR longitudinal bunch compression cavity

    International Nuclear Information System (INIS)

    Yin Dayu; Li Peng; Liu Yong; Xie Qingchun

    2009-01-01

    The scheme of longitudinal bunch compression cavity for the Cooling Storage Ring (CSR)is an important issue. Plasma physics experiments require high density heavy ion beam and short pulsed bunch,which can be produced by non-adiabatic compression of bunch implemented by a fast compression with 90 degree rotation in the longitudinal phase space. The phase space rotation in fast compression is initiated by a fast jump of the RF-voltage amplitude. For this purpose, the CSR longitudinal bunch compression cavity, loaded with FINEMET-FT-1M is studied and simulated with MAFIA code. In this paper, the CSR longitudinal bunch compression cavity is simulated and the initial bunch length of 238 U 72+ with 250 MeV/u will be compressed from 200 ns to 50 ns.The construction and RF properties of the CSR longitudinal bunch compression cavity are simulated and calculated also with MAFIA code. The operation frequency of the cavity is 1.15 MHz with peak voltage of 80 kV, and the cavity can be used to compress heavy ions in the CSR. (authors)

  16. Azimuthal asymmetries of the charged particle densities in EAS in the range of KASCADE-Grande

    International Nuclear Information System (INIS)

    Sima, O.; Morariu, C.; Manailescu, C.; Rebel, H.; Haungs, A.

    2009-03-01

    The reconstruction of Extended Air Showers (EAS) observed by ground level particle detectors is based on the characteristics of observables like particle lateral density (PLD), arrival time signals etc. Lateral densities, inferred from detector data, are usually parameterized by applying various lateral distribution functions (LDF). The LDFs are used in turn for evaluating quantities like the total number of particles, the density at particular radial distances. Typical expressions for LDFs anticipate azimuthal symmetry of the density around the shower axis. The deviations of the particle lateral density from this assumption are smoothed out in the case of compact arrays like KASCADE, but not in the case of arrays like Grande, which only sample a smaller part of the azimuthal variation. In this report we discuss the origin of the asymmetry: geometric, attenuation and geomagnetic effects. Geometric effects occur in the case of inclined showers, due to the fact that the observations are made in a plane different from the intrinsic shower plane. Hence the projection procedure from the observational plane to the relevant normal shower plane plays a significant role. Attenuation effects arise from the differences between the distances travelled by particles that reach the ground at the same radial coordinate but with various azimuthal positions in the case of inclined showers. The influence of the geomagnetic field distorts additionally the charged particle distributions in a way specific to the geomagnetic location. Based on dedicated CORSIKA simulations we have evaluated the magnitude of the effects. Focused to geometric and attenuation effects, procedures for minimizing the effects of the azimuthal asymmetry of lateral density in the intrinsic shower plane were developed. The consequences of the reconstruction of the charge particle sizes determined with the Grande array are also discussed and a procedure for practical application of restoring the azimuthal symmetry

  17. Microarray analysis of mandible regionalization during mouse development

    Czech Academy of Sciences Publication Activity Database

    Langová, Petra; Balková, Simona; Buchtová, Marcela

    2015-01-01

    Roč. 159, Suppl 1 (2015), S24-S24 ISSN 1213-8118. [Morphology 2015. International Congress of the Czech Anatomical Society /49./. Lojda Symposium on Histochemistry /52./. 06.09.2015-08.09.2015, Olomouc] R&D Projects: GA ČR GB14-37368G Institutional support: RVO:67985904 Keywords : mouse development Subject RIV: EA - Cell Biology

  18. A Longitudinal Analysis of Television Advertising Effects on Adolescents.

    Science.gov (United States)

    Moore, Roy L.; Moschis, George P.

    A longitudinal study examined both the short term and the long term effects of television advertising on the development of adolescents' consumption-related orientations. Questionnaires were administered to 556 adolescents in a number of schools in a southern state; a second wave of questionnaires was administered to a subsample of 230 of these…

  19. Longitudinal and transverse structure functions in decaying nearly homogeneous and isotropic turbulence

    International Nuclear Information System (INIS)

    Ahmad Imtiaz; Lu Zhi-Ming; Liu Yu-Lu

    2014-01-01

    Streamwise evolution of longitudinal and transverse velocity structure functions in a decaying homogeneous and nearly isotropic turbulence is reported for Reynolds numbers Re λ up to 720. First, two theoretical relations between longitudinal and transverse structure functions are examined in the light of recently derived relations and the results show that the low-order transverse structure functions can be well approximated by longitudinal ones within the sub-inertial range. Reconstruction of fourth-order transverse structure functions with a recently proposed relation by Grauer et al. is comparatively less valid than the relation already proposed by Antonia et al. Secondly, extended self-similarity methods are used to measure the scaling exponents up to order eight and the streamwise evolution of scaling exponents is explored. The scaling exponents of longitudinal structure functions are, at first location, close to Zybin's model, and at the fourth location, close to She—Leveque model. No obvious trend is found for the streamwise evolution of longitudinal scaling exponents, whereas, on the contrary, transverse scaling exponents become slightly smaller with the development of a steamwise direction. Finally, the stremwise variation of the order-dependent isotropy ratio indicates the turbulence at the last location is closer to isotropic than the other three locations. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  20. Impact of videogame play on the brain's microstructural properties: cross-sectional and longitudinal analyses

    Science.gov (United States)

    Takeuchi, H; Taki, Y; Hashizume, H; Asano, K; Asano, M; Sassa, Y; Yokota, S; Kotozaki, Y; Nouchi, R; Kawashima, R

    2016-01-01

    Videogame play (VGP) has been associated with numerous preferred and non-preferred effects. However, the effects of VGP on the development of microstructural properties in children, particularly those associated with negative psychological consequences of VGP, have not been identified to date. The purpose of this study was to investigate this issue through cross-sectional and longitudinal prospective analyses. In the present study of humans, we used the diffusion tensor imaging mean diffusivity (MD) measurement to measure microstructural properties and examined cross-sectional correlations with the amount of VGP in 114 boys and 126 girls. We also assessed correlations between the amount of VGP and longitudinal changes in MD that developed after 3.0±0.3 (s.d.) years in 95 boys and 94 girls. After correcting for confounding factors, we found that the amount of VGP was associated with increased MD in the left middle, inferior and orbital frontal cortex; left pallidum; left putamen; left hippocampus; left caudate; right putamen; right insula; and thalamus in both cross-sectional and longitudinal analyses. Regardless of intelligence quotient type, higher MD in the areas of the left thalamus, left hippocampus, left putamen, left insula and left Heschl gyrus was associated with lower intelligence. We also confirmed an association between the amount of VGP and decreased verbal intelligence in both cross-sectional and longitudinal analyses. In conclusion, increased VGP is directly or indirectly associated with delayed development of the microstructure in extensive brain regions and verbal intelligence. PMID:26728566

  1. Impact of videogame play on the brain's microstructural properties: cross-sectional and longitudinal analyses.

    Science.gov (United States)

    Takeuchi, H; Taki, Y; Hashizume, H; Asano, K; Asano, M; Sassa, Y; Yokota, S; Kotozaki, Y; Nouchi, R; Kawashima, R

    2016-12-01

    Videogame play (VGP) has been associated with numerous preferred and non-preferred effects. However, the effects of VGP on the development of microstructural properties in children, particularly those associated with negative psychological consequences of VGP, have not been identified to date. The purpose of this study was to investigate this issue through cross-sectional and longitudinal prospective analyses. In the present study of humans, we used the diffusion tensor imaging mean diffusivity (MD) measurement to measure microstructural properties and examined cross-sectional correlations with the amount of VGP in 114 boys and 126 girls. We also assessed correlations between the amount of VGP and longitudinal changes in MD that developed after 3.0±0.3 (s.d.) years in 95 boys and 94 girls. After correcting for confounding factors, we found that the amount of VGP was associated with increased MD in the left middle, inferior and orbital frontal cortex; left pallidum; left putamen; left hippocampus; left caudate; right putamen; right insula; and thalamus in both cross-sectional and longitudinal analyses. Regardless of intelligence quotient type, higher MD in the areas of the left thalamus, left hippocampus, left putamen, left insula and left Heschl gyrus was associated with lower intelligence. We also confirmed an association between the amount of VGP and decreased verbal intelligence in both cross-sectional and longitudinal analyses. In conclusion, increased VGP is directly or indirectly associated with delayed development of the microstructure in extensive brain regions and verbal intelligence.

  2. Simultaneous maximum a posteriori longitudinal PET image reconstruction

    Science.gov (United States)

    Ellis, Sam; Reader, Andrew J.

    2017-09-01

    Positron emission tomography (PET) is frequently used to monitor functional changes that occur over extended time scales, for example in longitudinal oncology PET protocols that include routine clinical follow-up scans to assess the efficacy of a course of treatment. In these contexts PET datasets are currently reconstructed into images using single-dataset reconstruction methods. Inspired by recently proposed joint PET-MR reconstruction methods, we propose to reconstruct longitudinal datasets simultaneously by using a joint penalty term in order to exploit the high degree of similarity between longitudinal images. We achieved this by penalising voxel-wise differences between pairs of longitudinal PET images in a one-step-late maximum a posteriori (MAP) fashion, resulting in the MAP simultaneous longitudinal reconstruction (SLR) method. The proposed method reduced reconstruction errors and visually improved images relative to standard maximum likelihood expectation-maximisation (ML-EM) in simulated 2D longitudinal brain tumour scans. In reconstructions of split real 3D data with inserted simulated tumours, noise across images reconstructed with MAP-SLR was reduced to levels equivalent to doubling the number of detected counts when using ML-EM. Furthermore, quantification of tumour activities was largely preserved over a variety of longitudinal tumour changes, including changes in size and activity, with larger changes inducing larger biases relative to standard ML-EM reconstructions. Similar improvements were observed for a range of counts levels, demonstrating the robustness of the method when used with a single penalty strength. The results suggest that longitudinal regularisation is a simple but effective method of improving reconstructed PET images without using resolution degrading priors.

  3. Longitudinal single-bunch instabilities

    International Nuclear Information System (INIS)

    Migliorati, M.; Palumbo, L.; Rome Univ. La Sapienza, Rome

    2001-02-01

    After introducing the concepts of longitudinal wakefield and coupling impedance, it is reviewed the theory of longitudinal single-bunch collective effects in storage rings. From the Fokker-Planck equation it is first derived the stationary solution describing the natural single-bunch regime, and then treat the problem of microwave instability, showing the different approaches used for estimating the threshold current. The lecture is ended with the semi-empirical laws that allow everyone to obtain the single-bunch behaviour above threshold, and with a description of the simulation codes that are now reliable tools for investigating all these effects

  4. LIA longitudinal coupling impedance

    International Nuclear Information System (INIS)

    Faltens, A.

    1980-01-01

    The beam generated fields enter into the problems of waveform generation and longitudinal stability. In the former, provision must be made for the longitudinally defocusing forces due to the space charge and the beam loading effects on the accelerating voltage due to the current of a presumably known bunch. In the latter, the concern is for the growth of unintentional perturbations to unacceptably large values through the interaction of the charge and current fluctuations with the rest of the beam and the surrounding structures. These beam generated electric fields may be related to the beam current through a coupling impedance

  5. Longitudinal beam dynamics

    International Nuclear Information System (INIS)

    Tecker, F

    2014-01-01

    The course gives a summary of longitudinal beam dynamics for both linear and circular accelerators. After discussing different types of acceleration methods and synchronism conditions, it focuses on the particle motion in synchrotrons

  6. Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model.

    Science.gov (United States)

    Gao, Y H; Li, C W; Wang, J Y; Tan, L H; Duanmu, C L; Jing, X H; Chang, X R; Liu, J L

    2017-06-01

    Increasing evidence supports that acupuncture intervention is an effective approach for intraoperative and postoperative pain. Neuron-microglia crosstalk, mediated by the purinergic P2X7 receptor (R)/fractalkine/CX3CR1 cascade in the spinal cord dorsal horn, plays a pivotal role in pain processing. However, its involvement in the analgesic effect of electroacupuncture (EA) remains unclear. In this study, a rat neck-incision pain model was established by making a longitudinal incision along the midline of the neck and subsequent repeated mechanical stimulation. EA stimulation was applied to bilateral LI18, LI4-PC6, or ST36-GB34. The thermal pain threshold, cervicospinal ATP concentration, expression levels of purinergic P2XR and P2YR subunits mRNAs, and fractalkine, CX3CR1 and p38 MAPK proteins, were detected separately. The neck incision induced strong thermal hyperalgesia and upregulation of spinal ATP within 48 h. No significant change was found in thermal hyperalgesia after a single session of EA intervention. However, a single session of EA dramatically enhanced the neck incision-induced upregulation of ATP and upregulated the expression of P2X7R, which was reversed by two sessions of EA. Two sessions of EA at bilateral LI18 or LI4-PC6 attenuated hyperalgesia significantly, accompanied with downregulation of P2X7R/fractalkine/ CX3CR1 signaling after three sessions of EA. EA stimulation of LI18 or LI4-PC6 alleviates thermal hyperalgesia in neck-incision pain rats, which may be associated with its effects in regulating the neck incision-induced increase of ATP and P2X7R and subsequently suppressing fractalkine/CX3CR1 signaling in the cervical spinal cord.

  7. Methodological developments in qualitative longitudinal research: the advantages and challenges of regular telephone contact with participants in a qualitative longitudinal interview study.

    Science.gov (United States)

    Carduff, Emma; Murray, Scott A; Kendall, Marilyn

    2015-04-11

    Qualitative longitudinal research is an evolving methodology, particularly within health care research. It facilitates a nuanced understanding of how phenomena change over time and is ripe for innovative approaches. However, methodological reflections which are tailored to health care research are scarce. This article provides a synthesised and practical account of the advantages and challenges of maintaining regular telephone contact between interviews with participants in a qualitative longitudinal study. Participants with metastatic colorectal cancer were interviewed at 3 time points over the course of a year. Half the group also received monthly telephone calls to explore the added value and the feasibility of capturing change as close to when it was occurring as possible. The data gathered from the telephone calls added context to the participants' overall narrative and informed subsequent interviews. The telephone calls meant we were able to capture change close to when it happened and there was a more evolved, and involved, relationship between the researcher and the participants who were called on a monthly basis. However, ethical challenges were amplified, boundaries of the participant/researcher relationship questioned, and there was the added analytical burden. The telephone calls facilitated a more nuanced understanding of the illness experience to emerge, when compared with the interview only group. The findings suggest that intensive telephone contact may be justified if retention is an issue, when the phenomena being studied is unpredictable and when participants feel disempowered or lack control. These are potential issues for research involving participants with long-term illness.

  8. Poverty and Child Development: A Longitudinal Study of the Impact of the Earned Income Tax Credit

    Science.gov (United States)

    Hamad, Rita; Rehkopf, David H.

    2016-01-01

    Although adverse socioeconomic conditions are correlated with worse child health and development, the effects of poverty-alleviation policies are less understood. We examined the associations of the Earned Income Tax Credit (EITC) on child development and used an instrumental variable approach to estimate the potential impacts of income. We used data from the US National Longitudinal Survey of Youth (n = 8,186) during 1986–2000 to examine effects on the Behavioral Problems Index (BPI) and Home Observation Measurement of the Environment inventory (HOME) scores. We conducted 2 analyses. In the first, we used multivariate linear regressions with child-level fixed effects to examine the association of EITC payment size with BPI and HOME scores; in the second, we used EITC payment size as an instrument to estimate the associations of income with BPI and HOME scores. In linear regression models, higher EITC payments were associated with improved short-term BPI scores (per $1,000, β = −0.57; P = 0.04). In instrumental variable analyses, higher income was associated with improved short-term BPI scores (per $1,000, β = −0.47; P = 0.01) and medium-term HOME scores (per $1,000, β = 0.64; P = 0.02). Our results suggest that both EITC benefits and higher income are associated with modest but meaningful improvements in child development. These findings provide valuable information for health researchers and policymakers for improving child health and development. PMID:27056961

  9. Longitudinal Control for Mengshi Autonomous Vehicle via Cloud Model

    Science.gov (United States)

    Gao, H. B.; Zhang, X. Y.; Li, D. Y.; Liu, Y. C.

    2018-03-01

    Dynamic robustness and stability control is a requirement for self-driving of autonomous vehicle. Longitudinal control method of autonomous is a key technique which has drawn the attention of industry and academe. In this paper, we present a longitudinal control algorithm based on cloud model for Mengshi autonomous vehicle to ensure the dynamic stability and tracking performance of Mengshi autonomous vehicle. An experiments is applied to test the implementation of the longitudinal control algorithm. Empirical results show that if the longitudinal control algorithm based Gauss cloud model are applied to calculate the acceleration, and the vehicles drive at different speeds, a stable longitudinal control effect is achieved.

  10. Mathematics, Language, and Learning: A Longitudinal Study of Elementary Teachers and Their Mathematics Teaching Practices

    OpenAIRE

    Yeh, Cathery

    2016-01-01

    Elementary school mathematics has gained increased attention in the last few decades. A growing field of research has studied the programmatic design and development of elementary mathematics teaching in teacher education, however, few studies have examined longitudinally the mathematics teaching of novice elementary teachers. Existing longitudinal studies on elementary mathematics teaching have generally focused on the effects of teacher preparation on their beginning practices and have exam...

  11. Ring RF and longitudinal dynamics in the SNS

    International Nuclear Information System (INIS)

    Blaskiewicz, M.; Brennan, J.M.; Brodowski, J.; Delong, J.; Meth, M.; Onillon, E.; Zaltsman, A.

    2000-01-01

    Average beam currents of 40 A will be present in the Spallation Neutron Source. Even though the entire cycle time is only one synchrotron oscillation the longitudinal phase space determines peak beam current and momentum spread. Both factors play a role in space charge and instability dynamics. Longitudinal simulations with beam loading and longitudinal space charge have been done in the design phase

  12. Boosted Multivariate Trees for Longitudinal Data

    Science.gov (United States)

    Pande, Amol; Li, Liang; Rajeswaran, Jeevanantham; Ehrlinger, John; Kogalur, Udaya B.; Blackstone, Eugene H.; Ishwaran, Hemant

    2017-01-01

    Machine learning methods provide a powerful approach for analyzing longitudinal data in which repeated measurements are observed for a subject over time. We boost multivariate trees to fit a novel flexible semi-nonparametric marginal model for longitudinal data. In this model, features are assumed to be nonparametric, while feature-time interactions are modeled semi-nonparametrically utilizing P-splines with estimated smoothing parameter. In order to avoid overfitting, we describe a relatively simple in sample cross-validation method which can be used to estimate the optimal boosting iteration and which has the surprising added benefit of stabilizing certain parameter estimates. Our new multivariate tree boosting method is shown to be highly flexible, robust to covariance misspecification and unbalanced designs, and resistant to overfitting in high dimensions. Feature selection can be used to identify important features and feature-time interactions. An application to longitudinal data of forced 1-second lung expiratory volume (FEV1) for lung transplant patients identifies an important feature-time interaction and illustrates the ease with which our method can find complex relationships in longitudinal data. PMID:29249866

  13. Preliminary results of a test of a longitudinal phase-space monitor

    International Nuclear Information System (INIS)

    Kikutani, Eiji; Funakoshi, Yoshihiro; Kawamoto, Takashi; Mimashi, Toshihiro

    1994-01-01

    A prototype of a longitudinal phase-space monitor has been developed in TRISTAN Main Ring at KEK. The principle of the monitor and its basic components are explained. Also a result of a preliminary beam test is given. (author)

  14. Does oral language underpin the development of later behavior problems? A longitudinal meta-analysis.

    Science.gov (United States)

    Chow, Jason C; Ekholm, Erik; Coleman, Heather

    2018-05-24

    The purpose of this article is to estimate the overall weighted mean effect of the relation between early language skills and later behavior problems in school-aged children. A systematic literature search yielded 19,790 unduplicated reports, and a structured search strategy and identification procedure yielded 25 unique data sets, with 114 effect sizes for analysis. Eligible reports were then coded, and effect sizes were extracted and synthesized via robust variance estimation and random-effects meta-analytic techniques. The overall correlation between early language and later behavior problems was negative and small (r = -.14, 95% confidence interval [CI] [-.16, -.11]), and controlling for demographic variables did not reduce the magnitude of the inverse relationship between language skill and problem behavior (r = -.16). Moderator analyses identified receptive language, parent-reported behavior measures, gender, and age as significant predictors of the association between language and behavior. This article corroborates the consistent findings of previous meta-analytic and longitudinal studies and further identifies areas, particularly around measurement, for future research. Furthermore, prospective longitudinal evaluations of the relations between language deficits and behavior problems with different types of measures (teacher-/parent-report, direct assessment, classroom observation) is warranted. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  15. Ethnic Differences in Peripheral Skeletal Development Among Urban South African Adolescents: A Ten-Year Longitudinal pQCT Study.

    Science.gov (United States)

    Schoenbuchner, Simon M; Pettifor, John M; Norris, Shane A; Micklesfield, Lisa K; Prentice, Ann; Ward, Kate A

    2017-12-01

    There are no longitudinal pQCT data of bone growth and development from sub-Saharan Africa, where rapid environmental, societal, and economic transitions are occurring, and where fracture rates are predicted to rise. The aim of this study was to compare skeletal development in black and white South African adolescents using longitudinal data from the Birth to Twenty study. The Birth to Twenty Bone Health subcohort consisted of 543 adolescents (261 [178 black] girls, 282 [201 black] boys). Annual pQCT measurements of the radial and tibial metaphysis and diaphysis were obtained between ages 12 and 22 years (distal metaphysis: cross-sectional area [CSA] and trabecular bone mineral density [BMD]; diaphysis: total and cortical CSA, cortical BMD, and polar stress-strain index [SSIp]). Age at peak height velocity (APHV) was calculated to account for differences in maturational timing between ethnic groups and sexes. Mixed-effects models were used to describe trajectories for each pQCT outcome. Likelihood-ratio tests were used to summarize the overall difference in trajectories between black and white participants within each sex. APHV (mean ± SD years) was similar in black (11.8 ± 0.8) and white (12.2 ± 1.0) girls, but delayed in black (14.2 ± 1.0) relative to white boys (13.3 ± 0.8). By 4 years post-APHV, white adolescents had significantly greater cortical CSA and SSIp than black adolescents at the radius. There were no significant differences at the radial metaphysis but there was some divergence, such that black adolescents had greater radial trabecular BMD by the end of follow-up. At the tibia, white adolescents had lower diaphyseal CSA and SSIp, and greater metaphyseal CSA. There was no ethnic difference in tibial trabecular BMD. There are ethnic differences in bone growth and development, independent of maturation, in South African adolescents. This work gives new insights into the possible etiology of childhood fractures, which occur most

  16. Longitudinal and bulk viscosities of Lennard-Jones fluids

    Science.gov (United States)

    Tankeshwar, K.; Pathak, K. N.; Ranganathan, S.

    1996-12-01

    Expressions for the longitudinal and bulk viscosities have been derived using Green Kubo formulae involving the time integral of the longitudinal and bulk stress autocorrelation functions. The time evolution of stress autocorrelation functions are determined using the Mori formalism and a memory function which is obtained from the Mori equation of motion. The memory function is of hyperbolic secant form and involves two parameters which are related to the microscopic sum rules of the respective autocorrelation function. We have derived expressions for the zeroth-, second-and fourth- order sum rules of the longitudinal and bulk stress autocorrelation functions. These involve static correlation functions up to four particles. The final expressions for these have been put in a form suitable for numerical calculations using low- order decoupling approximations. The numerical results have been obtained for the sum rules of longitudinal and bulk stress autocorrelation functions. These have been used to calculate the longitudinal and bulk viscosities and time evolution of the longitudinal stress autocorrelation function of the Lennard-Jones fluids over wide ranges of densities and temperatures. We have compared our results with the available computer simulation data and found reasonable agreement.

  17. The ONS Longitudinal Study--a prestigious past and a bright future.

    Science.gov (United States)

    Goldring, Shayla; Newman, Jim

    2010-01-01

    This issue of Population Trends includes a number of articles and reports resulting from research based on the ONS Longitudinal Study (ONS LS). They have been drawn together in one issue to highlight the value of this type of study for demographic research.2009 marked the 35th anniversary of the establishment of the ONS LS. The study now contains data from the last four censuses (1971 to 2001), linked to vital events data since 1971, for a sample of one per cent of the population of England and Wales.More recently, sister studies have been established in Scotland and Northern Ireland. The Scottish Longitudinal Study (SLS) started with 1991 Census data and the Northern Ireland Longitudinal Study (NILS)started with 2001 Census data.The lead article in this issue comes from an exemplar project that was established to explore how to utilise the three studies to carry out UK-wide longitudinal analysis. Two different methods were used to analyse socio-economic and country level differences in health and mortality across the studies. The article summarises the results of this analysis, reports on the relative strengths of the different methods used, and draws attention to a number of new resources that have been developed by the project researchers as aids to using all three studies.This is an excellent example of collaborative working across the UK, involving researchers from the Centre for Longitudinal Study Information and User Support (CeLSIUS) at the London School of Hygiene and Tropical Medicine, the Longitudinal Studies Centre - Scotland (LSCS) at the University of St.Andrews and the Northern Ireland Longitudinal Study - Research Support Unit (NILS-RSU) at Queen's University Belfast. The project also involved collaboration between ONS, the General Register Office for Scotland (GROS) and the Northern Ireland Statistics and Research Agency (NISRA) to ensure the secure transfer and handling of data from the three studies so that it could be brought together in one

  18. Imitation (rather than core language) predicts pragmatic development in young children with ASD: a preliminary longitudinal study using CDI parental reports.

    Science.gov (United States)

    Miniscalco, Carmela; Rudling, Maja; Råstam, Maria; Gillberg, Christopher; Johnels, Jakob Åsberg

    2014-01-01

    Research in the last decades has clearly pointed to the important role of language and communicative level when trying to understand developmental trajectories in children with autism spectrum disorders (ASD). The purpose of this longitudinal study was to investigate whether (1) core language skills, measured as expressive vocabulary and grammar, and/or (2) pre-linguistic social-communicative skills, including gestures and imitation abilities, drive pragmatic language development in young children with ASD. We examined correlates and longitudinal predictors of pragmatic growth in a sample of 34 children with Autism spectrum disorder (ASD), whose parents were given parts of two MacArthur Communicative Developmental Inventories (CDI: Words & Gestures and CDI: Words & Sentences) for completion at two time points (at time 1 the mean child age was 41 months, and at time 2 it was 54 months). A novel feature in this study is that the relevant parts from both CDI forms were included at both time points, allowing us to examine whether pre-linguistic social-communication skills (e.g. imitation and gesturing) and/or core language skills (i.e. grammar and vocabulary) predict pragmatic language growth. The results show that basically all pre-linguistic, linguistic and pragmatic skills were associated concurrently. When controlling for possible confounders and for the autoregressive effect, imitation skills predicted pragmatic growth over time, whereas core language did not. This could only have been shown by the use of both CDI forms. This preliminary study may be of both conceptual and methodological importance for research in the field of language and communication development in ASD. Imitation may play a pivotal role in the development of subsequent conversational pragmatic abilities in young children with ASD. Future research should be directed at unravelling the mechanisms underlying this association. © 2014 Royal College of Speech and Language Therapists.

  19. Estimators for longitudinal latent exposure models: examining measurement model assumptions.

    Science.gov (United States)

    Sánchez, Brisa N; Kim, Sehee; Sammel, Mary D

    2017-06-15

    Latent variable (LV) models are increasingly being used in environmental epidemiology as a way to summarize multiple environmental exposures and thus minimize statistical concerns that arise in multiple regression. LV models may be especially useful when multivariate exposures are collected repeatedly over time. LV models can accommodate a variety of assumptions but, at the same time, present the user with many choices for model specification particularly in the case of exposure data collected repeatedly over time. For instance, the user could assume conditional independence of observed exposure biomarkers given the latent exposure and, in the case of longitudinal latent exposure variables, time invariance of the measurement model. Choosing which assumptions to relax is not always straightforward. We were motivated by a study of prenatal lead exposure and mental development, where assumptions of the measurement model for the time-changing longitudinal exposure have appreciable impact on (maximum-likelihood) inferences about the health effects of lead exposure. Although we were not particularly interested in characterizing the change of the LV itself, imposing a longitudinal LV structure on the repeated multivariate exposure measures could result in high efficiency gains for the exposure-disease association. We examine the biases of maximum likelihood estimators when assumptions about the measurement model for the longitudinal latent exposure variable are violated. We adapt existing instrumental variable estimators to the case of longitudinal exposures and propose them as an alternative to estimate the health effects of a time-changing latent predictor. We show that instrumental variable estimators remain unbiased for a wide range of data generating models and have advantages in terms of mean squared error. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  20. Creating a longitudinal integrated clerkship with mutual benefits for an academic medical center and a community health system.

    Science.gov (United States)

    Poncelet, Ann Noelle; Mazotti, Lindsay A; Blumberg, Bruce; Wamsley, Maria A; Grennan, Tim; Shore, William B

    2014-01-01

    The longitudinal integrated clerkship is a model of clinical education driven by tenets of social cognitive theory, situated learning, and workplace learning theories, and built on a foundation of continuity between students, patients, clinicians, and a system of care. Principles and goals of this type of clerkship are aligned with primary care principles, including patient-centered care and systems-based practice. Academic medical centers can partner with community health systems around a longitudinal integrated clerkship to provide mutual benefits for both organizations, creating a sustainable model of clinical training that addresses medical education and community health needs. A successful one-year longitudinal integrated clerkship was created in partnership between an academic medical center and an integrated community health system. Compared with traditional clerkship students, students in this clerkship had better scores on Clinical Performance Examinations, internal medicine examinations, and high perceptions of direct observation of clinical skills.Advantages for the academic medical center include mitigating the resources required to run a longitudinal integrated clerkship while providing primary care training and addressing core competencies such as systems-based practice, practice-based learning, and interprofessional care. Advantages for the community health system include faculty development, academic appointments, professional satisfaction, and recruitment.Success factors include continued support and investment from both organizations' leadership, high-quality faculty development, incentives for community-based physician educators, and emphasis on the mutually beneficial relationship for both organizations. Development of a longitudinal integrated clerkship in a community health system can serve as a model for developing and expanding these clerkship options for academic medical centers.

  1. Child regulative temperament as a mediator of parenting in the development of depressive symptoms: a longitudinal study from early childhood to preadolescence.

    Science.gov (United States)

    Pitzer, Martina; Esser, Guenter; Schmidt, Martin H; Hohm, Erika; Banaschewski, Tobias; Laucht, Manfred

    2017-05-01

    Child temperament as well as parenting behaviors have been linked to adolescent depression. Beyond their main effects, the interplay between these factors is of interest. For example, in an interactive model, a differential susceptibility of temperamental variants to parenting has been suggested. However, so far, the differential susceptibility hypothesis has mostly been studied with a focus on externalizing disorders. On the other hand, parenting may shape the child's temperament and vice versa in a transactional process. In a prospective, longitudinal at-risk sample (163 boys, 176 girls), we assessed emotional (easy-difficult) and regulative (self-control) temperament at ages 4.5, and 8 years, respectively, as well as parenting quality at age 4.5 years using the HOME inventory. Hierarchical linear regression analysis was used to investigate the prediction of depressive symptoms at age 11, measured by the Child Depression Inventory, including interaction terms between the temperament variable and parenting. We additionally tested whether parenting was mediated by child temperament. As previously reported, both self-control and parenting were longitudinally associated with preadolescent depressive symptoms. There were no interactive effects between temperament and parenting. However, the effects of parenting were partly mediated by self-control. Our data do not support a differential susceptibility of temperamental variants in the development of preadolescent depression. However, our results are in line with the assumption that parenting may shape young children's temperament, with positive parenting in the early childhood fostering the development of regulative temperament.

  2. Longitudinal emission tomography of thyroid and heart

    International Nuclear Information System (INIS)

    Giessen, J.W. van.

    1986-01-01

    In this thesis three devices are discussed for longitudinal emission tomography, one of which has been developed for myocardial imaging and the other two for thyroid imaging. Longitudinal emission tomography is a technique which enables three-dimensional reconstruction of the radioactivity distribution within an organ from two-dimensional distributions on a detector surface. In Ch. 1 a general survey is given of the clinical environment in which the devices will be used. Ch. 2 discusses a well-known technique for myocardial imaging: seven-pinhole tomography. In Ch. 3 this technique is applied to imaging of the thyroid. Three different reconstruction methods have been applied to the data collected with the system (from phantoms as well as from patients) and the results have been evaluated. Ch. 4 discusses simulation studies which were carried out in order to investigate the potentialities of a time-coded aperture (TCA) system designed for thyroid tomography. In Ch. 5 a prototype is tested of the time coded aperture in a clinical environment. The last chapter presents a comparison between the (thyroid) 7P collimator and the TCA device. (Auth.)

  3. Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors.

    Science.gov (United States)

    Lee, Jung-Rok; Appelmann, Iris; Miething, Cornelius; Shultz, Tyler O; Ruderman, Daniel; Kim, Dokyoon; Mallick, Parag; Lowe, Scott W; Wang, Shan X

    2018-01-01

    Cancer proteomics is the manifestation of relevant biological processes in cancer development. Thus, it reflects the activities of tumor cells, host-tumor interactions, and systemic responses to cancer therapy. To understand the causal effects of tumorigenesis or therapeutic intervention, longitudinal studies are greatly needed. However, most of the conventional mouse experiments are unlikely to accommodate frequent collection of serum samples with a large enough volume for multiple protein assays towards single-object analysis. Here, we present a technique based on magneto-nanosensors to longitudinally monitor the protein profiles in individual mice of lymphoma models using a small volume of a sample for multiplex assays. Methods: Drug-sensitive and -resistant cancer cell lines were used to develop the mouse models that render different outcomes upon the drug treatment. Two groups of mice were inoculated with each cell line, and treated with either cyclophosphamide or vehicle solution. Serum samples taken longitudinally from each mouse in the groups were measured with 6-plex magneto-nanosensor cytokine assays. To find the origin of IL-6, experiments were performed using IL-6 knock-out mice. Results: The differences in serum IL-6 and GCSF levels between the drug-treated and untreated groups were revealed by the magneto-nanosensor measurement on individual mice. Using the multiplex assays and mouse models, we found that IL-6 is secreted by the host in the presence of tumor cells upon the drug treatment. Conclusion: The multiplex magneto-nanosensor assays enable longitudinal proteomic studies on mouse tumor models to understand tumor development and therapy mechanisms more precisely within a single biological object.

  4. Time Perspective and Identity Formation: Short-Term Longitudinal Dynamics in College Students

    Science.gov (United States)

    Luyckx, Koen; Lens, Willy; Smits, Ilse; Goossens, Luc

    2010-01-01

    Planning for the future and developing a personalized identity are conceived of as important developmental tasks that adolescents and emerging adults are confronted with on the pathway to adulthood. The present study set out to examine whether both tasks develop in tandem by using a short-term longitudinal dataset consisting of 371 college…

  5. Foundational Elements of Applied Simulation Theory: Development and Implementation of a Longitudinal Simulation Educator Curriculum.

    Science.gov (United States)

    Chiu, Michelle; Posner, Glenn; Humphrey-Murto, Susan

    2017-01-27

    Simulation-based education has gained popularity, yet many faculty members feel inadequately prepared to teach using this technique. Fellowship training in medical education exists, but there is little information regarding simulation or formal educational programs therein. In our institution, simulation fellowships were offered by individual clinical departments. We recognized the need for a formal curriculum in educational theory. Kern's approach to curriculum development was used to develop, implement, and evaluate the Foundational Elements of Applied Simulation Theory (FEAST) curriculum. Needs assessments resulted in a 26-topic curriculum; each biweekly session built upon the previous. Components essential to success included setting goals and objectives for each interactive session and having dedicated faculty, collaborative leadership and administrative support for the curriculum. Evaluation data was collated and analyzed annually via anonymous feedback surveys, focus groups, and retrospective pre-post self-assessment questionnaires. Data collected from 32 fellows over five years of implementation showed that the curriculum improved knowledge, challenged thinking, and was excellent preparation for a career in simulation-based medical education. Themes arising from focus groups demonstrated that participants valued faculty expertise and the structure, practicality, and content of the curriculum. We present a longitudinal simulation educator curriculum that adheres to a well-described framework of curriculum development. Program evaluation shows that FEAST has increased participant knowledge in key areas relevant to simulation-based education and that the curriculum has been successful in meeting the needs of novice simulation educators. Insights and practice points are offered for educators wishing to implement a similar curriculum in their institution.

  6. Parenting Style and Behavior as Longitudinal Predictors of Adolescent Alcohol Use.

    Science.gov (United States)

    Minaie, Matin Ghayour; Hui, Ka Kit; Leung, Rachel K; Toumbourou, John W; King, Ross M

    2015-09-01

    Adolescent alcohol use is a serious problem in Australia and other nations. Longitudinal data on family predictors are valuable to guide parental education efforts. The present study tested Baumrind's proposal that parenting styles are direct predictors of adolescent alcohol use. Latent class modeling was used to investigate adolescent perceptions of parenting styles and multivariate regression to examine their predictive effect on the development of adolescent alcohol use. The data set comprised 2,081 secondary school students (55.9% female) from metropolitan Melbourne, Australia, who completed three waves of annual longitudinal data starting in 2004. Baumrind's parenting styles were significant predictors in unadjusted analyses, but these effects were not maintained in multivariate models that also included parenting behavior dimensions. Family influences on the development of adolescent alcohol use appear to operate more directly through specific family management behaviors rather than through more global parenting styles.

  7. Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer's Disease Spectrum: Development of the Classifier and Longitudinal Evaluation.

    Science.gov (United States)

    Lee, Jin San; Kim, Changsoo; Shin, Jeong-Hyeon; Cho, Hanna; Shin, Dae-Seock; Kim, Nakyoung; Kim, Hee Jin; Kim, Yeshin; Lockhart, Samuel N; Na, Duk L; Seo, Sang Won; Seong, Joon-Kyung

    2018-03-07

    To develop a new method for measuring Alzheimer's disease (AD)-specific similarity of cortical atrophy patterns at the individual-level, we employed an individual-level machine learning algorithm. A total of 869 cognitively normal (CN) individuals and 473 patients with probable AD dementia who underwent high-resolution 3T brain MRI were included. We propose a machine learning-based method for measuring the similarity of an individual subject's cortical atrophy pattern with that of a representative AD patient cohort. In addition, we validated this similarity measure in two longitudinal cohorts consisting of 79 patients with amnestic-mild cognitive impairment (aMCI) and 27 patients with probable AD dementia. Surface-based morphometry classifier for discriminating AD from CN showed sensitivity and specificity values of 87.1% and 93.3%, respectively. In the longitudinal validation study, aMCI-converts had higher atrophy similarity at both baseline (p < 0.001) and first year visits (p < 0.001) relative to non-converters. Similarly, AD patients with faster decline had higher atrophy similarity than slower decliners at baseline (p = 0.042), first year (p = 0.028), and third year visits (p = 0.027). The AD-specific atrophy similarity measure is a novel approach for the prediction of dementia risk and for the evaluation of AD trajectories on an individual subject level.

  8. Longitudinal drop-out and weighting against its bias

    Directory of Open Access Journals (Sweden)

    Steffen C. E. Schmidt

    2017-12-01

    Full Text Available Abstract Background The bias caused by drop-out is an important factor in large population-based epidemiological studies. Many studies account for it by weighting their longitudinal data, but to date there is no detailed final approach for how to conduct these weights. Methods In this study we describe the observed longitudinal bias and a three-step longitudinal weighting approach used for the longitudinal data in the MoMo baseline (N = 4528, 4–17 years and wave 1 study with 2807 (62% participants between 2003 and 2012. Results The most meaningful drop-out predictors were socioeconomic status of the household, socioeconomic characteristics of the mother and daily TV usage. Weighting reduced the bias between the longitudinal participants and the baseline sample, and also increased variance by 5% to 35% with a final weighting efficiency of 41.67%. Conclusions We conclude that a weighting procedure is important to reduce longitudinal bias in health-oriented epidemiological studies and suggest identifying the most influencing variables in the first step, then use logistic regression modeling to calculate the inverse of the probability of participation in the second step, and finally trim and standardize the weights in the third step.

  9. Tooth-bone morphogenesis during postnatal stages of mouse first molar development

    Czech Academy of Sciences Publication Activity Database

    Lungová, V.; Radlanski, R.J.; Tucker, A. S.; Renz, H.; Míšek, Ivan; Matalová, Eva

    2011-01-01

    Roč. 218, č. 6 (2011), s. 699-716 ISSN 0021-8782 R&D Projects: GA ČR GC524/08/J032; GA MZd(CZ) NT11420 Institutional research plan: CEZ:AV0Z50450515 Keywords : apoptosis * dentition * development Subject RIV: EA - Cell Biology Impact factor: 2.370, year: 2011

  10. Longitudinal feedback system for PEP

    International Nuclear Information System (INIS)

    Allen, M.A.; Cornacchia, M.; Millich, A.

    1979-02-01

    Whether the wide bandwidth longitudinal feedback system described in this paper is made to act on the individual modes in frequency domain or on the individual bunches in time domain, it represents a clean and efficient way of damping the longitudinal oscillations without influencing other beam parameters such as bunch shape or synchrotron frequency distribution. The frequency domain feedback presents the advantage of providing information on which modes are unstable and on their risetimes, which may be helpful in locating dangerous resonators in the ring

  11. Continuity of Genetic and Environmental Influences on Cognition across the Life Span: A Meta-Analysis of Longitudinal Twin and Adoption Studies

    Science.gov (United States)

    Tucker-Drob, Elliot M.; Briley, Daniel A.

    2014-01-01

    The longitudinal rank-order stability of cognitive ability increases dramatically over the lifespan. Multiple theoretical perspectives have proposed that genetic and/or environmental mechanisms underlie the longitudinal stability of cognition, and developmental trends therein. However, the patterns of stability of genetic and environmental influences on cognition over the lifespan largely remain poorly understood. We searched for longitudinal studies of cognition that reported raw genetically-informative longitudinal correlations or parameter estimates from longitudinal behavior genetic models. We identified 150 combinations of time points and measures from 15 independent longitudinal samples. In total, longitudinal data came from 4,538 monozygotic twin pairs raised together, 7,777 dizygotic twin pairs raised together, 34 monozygotic twin pairs raised apart, 78 dizygotic twin pairs raised apart, 141 adoptive sibling pairs, and 143 non-adoptive sibling pairs, ranging in age from infancy through late adulthood. At all ages, cross-time genetic correlations and shared environmental correlations were substantially larger than cross-time nonshared environmental correlations. Cross-time correlations for genetic and shared environmental components were low during early childhood, increased sharply over child development, and remained relatively high from adolescence through late adulthood. Cross-time correlations for nonshared environmental components were low across childhood and increased gradually to moderate magnitudes in adulthood. Increasing phenotypic stability over child development was almost entirely mediated by genetic factors. Time-based decay of genetic and shared environmental stability was more pronounced earlier in child development. Results are interpreted in reference to theories of gene-environment interaction and correlation. PMID:24611582

  12. Prediction in Child Development: A Longitudinal Study of Adoptive and Nonadoptive Families. The Delaware Family Study.

    Science.gov (United States)

    Hoopes, Janet L.

    A longitudinal study was conducted to determine factors predicting successful adoptions before placement and to identify differences and similarities between adoptive and biological families. Data collected on both adopted children and on their adoptive families before placement was related to data collected on the same children and families 6…

  13. Longitudinal fluctuations and decorrelation of anisotropic flow

    Energy Technology Data Exchange (ETDEWEB)

    Pang, Long-Gang [Frankfurt Institute for Advanced Studies, Ruth-Moufang-Strasse 1, 60438 Frankfurt am Main (Germany); Petersen, Hannah [Frankfurt Institute for Advanced Studies, Ruth-Moufang-Strasse 1, 60438 Frankfurt am Main (Germany); Institute for Theoretical Physics, Goethe University, Max-von-Laue-Strasse 1, 60438 Frankfurt am Main (Germany); GSI Helmholtzzentrum für Schwerionenforschung, Planckstr. 1, 64291 Darmstadt (Germany); Qin, Guang-You [Key Laboratory of Quark & Lepton Physics (MOE) and Institute of Particle Physics, Central China Normal University, Wuhan 430079 (China); Roy, Victor [Institute for Theoretical Physics, Goethe University, Max-von-Laue-Strasse 1, 60438 Frankfurt am Main (Germany); Wang, Xin-Nian [Key Laboratory of Quark & Lepton Physics (MOE) and Institute of Particle Physics, Central China Normal University, Wuhan 430079 (China); Nuclear Science Division MS70R0319, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2016-12-15

    We investigate the decorrelation of 2nd and 3rd order anisotropic flow for charged particles in two different pseudo rapidity (η) windows by varying the pseudo rapidity gap, in an event-by-event (3+1)D ideal hydrodynamic model, with fluctuating initial conditions from A Multi-Phase Transport (AMPT) model. We visualize the parton distribution at initial state for Pb+Pb collisions at LHC and Au+Au collisions at RHIC, and demonstrate the longitudinal fluctuations originating from the asymmetry between forward and backward going participants, the fluctuations of the string length and the fluctuations due to finite number of partons at different beam energies. The decorrelation of anisotropic flow of final hadrons with large η gaps is found to originate from the spatial decorrelation along the longitudinal direction in the AMPT initial conditions through hydrodynamic evolution. The agreement between our results and recent CMS data in most centralities suggests that the string-like mechanism of initial parton production in AMPT model captures the initial longitudinal fluctuation that is responsible for the measured decorrelation of anisotropic flow in Pb+Pb collisions at LHC. Our predictions for Au+Au collisions at the highest RHIC energy show stronger longitudinal decorrelation than at LHC, indicating larger longitudinal fluctuations at lower beam energies.

  14. Parental education and family income affect birthweight, early longitudinal growth and body mass index development differently.

    Science.gov (United States)

    Bramsved, Rebecka; Regber, Susann; Novak, Daniel; Mehlig, Kirsten; Lissner, Lauren; Mårild, Staffan

    2018-01-07

    This study investigated the effects of two parental socio-economic characteristics, education and income, on growth and risk of obesity in children from birth to 8 years of age. Longitudinal growth data and national register-based information on socio-economic characteristics were available for 3,030 Swedish children. The development of body mass index (BMI) and height was compared in groups dichotomised by parental education and income. Low parental education was associated with a higher BMI from 4 years of age, independent of income, immigrant background, maternal BMI and smoking during pregnancy. Low family income was associated with a lower birthweight, but did not independently predict BMI development. At 8 years of age, children from less educated families had a three times higher risk of obesity, independent of parental income. Children whose parents had fewer years of education but high income had significantly higher height than all other children. Parental education protected against childhood obesity, even after adjusting for income and other important parental characteristics. Income-related differences in height, despite similar BMIs, raise questions about body composition and metabolic risk profiles. The dominant role of education underscores the value of health literacy initiatives for the parents of young children. ©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  15. Posterior longitudinal ligament status in cervical spine bilateral facet dislocations

    International Nuclear Information System (INIS)

    Carrino, John A.; Manton, Geoffrey L.; Morrison, William B.; Flanders, Adam E.; Vaccaro, Alex R.; Schweitzer, Mark E.

    2006-01-01

    It is generally accepted that cervical spine bilateral facet dislocation results in complete disruption of the posterior longitudinal ligament. The goal of this study was to evaluate the integrity of numerous spine-stabilizing structures by MRI, and to determine if any associations between injury patterns exist with respect to the posterior longitudinal ligament status. Retrospective case series. A retrospective review was performed of 30 cervical spine injury subjects with bilateral facet dislocation. Assessment of 1.5T MRI images was carried out for: intervertebral disc disruption, facet fracture, and ligamentous disruption. Statistical analyses were performed to evaluate for associations between various injury patterns and posterior longitudinal ligament status. The frequency of MRI abnormalities was: anterior longitudinal ligament disruption (26.7%), disc herniation or disruption (90%), posterior longitudinal ligament disruption (40%), facet fracture (63.3%) and disruption of the posterior column ligament complex (97%). There were no significant associations between injury to the posterior longitudinal ligament and other structures. Compared to surgical reports, MRI was accurate for determining the status for 24 of 26 ligaments (three of three anterior longitudinal ligament, seven of nine posterior longitudinal ligament, and 14 of 14 posterior column ligament complex) but generated false negatives in two instances (in both MRI showed an intact posterior longitudinal ligament that was torn at surgery). (orig.)

  16. Residents' perceptions of an integrated longitudinal curriculum: a qualitative study.

    Science.gov (United States)

    Lubitz, Rebecca; Lee, Joseph; Hillier, Loretta M

    2015-01-01

    The purpose of this study was to explore family medicine residents' perceptions of a newly restructured integrated longitudinal curriculum. A purposeful sample of 16 family medicine residents participated in focus group interviews conducted from a grounded theory perspective to identify the characteristics of this training model that contribute to and that challenge learning. Eight key themes were identified: continuity of care, relevance to family medicine, autonomy, program-focused preparation, professional development as facilitated by role modeling, patient volume, clarity of expectations for learners, and logistics. Positive learning experiences were marked by high levels of autonomy, continuity, and relevance to family medicine. Less favorable learning experiences were characterized by limited opportunities for continuity of care, limited relevance to family medicine practice and unclear expectations for the resident's role. Family physician-led learning experiences contributed to residents' understanding of the full scope of family medicine practice, more so than specialist-led experiences. The logistics of implementing the integrated block were challenging and negatively impacted continuity and learning. This study suggests that an integrated longitudinalized family medicine block training model has the potential to support the principles of a longitudinal integrated competency-based curriculum to effectively prepare residents for family medicine practice.

  17. Existence of longitudinal waves in pre-stressed anisotropic elastic ...

    Indian Academy of Sciences (India)

    waves is truly longitudinal. Longitudinal wave in an anisotropic elastic medium is defined as the wave motion in which the particle motion (i.e., the. Keywords. General anisotropy; elastic stiffness; pre-stress; group velocity; ray direction; longitudinal waves; polarization. J. Earth Syst. Sci. 118, No. 6, December 2009, pp. 677– ...

  18. Does labour epidural slow the progress of labour and lead to complications? Obstetricians' perception working in private and public sector teaching hospitals in a developing country.

    Science.gov (United States)

    Sohaib, Muhammad; Ismail, Samina

    2015-12-01

    Obstetricians play a major role in the decision making for provision of analgesia for the woman in labour. As epidural analgesia (EA) is the most preferred technique, it is important to know obstetricians' perception regarding its effect on progress of labour and associated complications. The 6 months cross-sectional study included 114 obstetricians from teaching hospitals. After informed consent, obstetricians were asked to fill a predesigned questionnaire containing 13 close ended questions regarding their perception on the effect of EA on progress of labour, EA complications and whether they would recommend EA to their patients or not. Other variables included age, gender, training in EA, practice type and hospital settings (private or public sector). Majority of the obstetricians had the perception of EA prolonging the first stage (89.5%) and second stage (98.2%) of labour, increasing the rate of caesarean section (87.7%), instrumental delivery (58.8%) and increasing the incidence of backache (85.5%). None of the obstetricians received any formal training in EA. Majority (84.2%) were not sure if they would recommend EA to their patients. When these responses were compared between public and private sector, a statistically higher percentage (P sector obstetricians had negative perception of EA. Perception of obstetrician regarding EA is contrary to the current evidence. There is a need to introduce formal curriculum on EA in obstetric training program and conduct regular refresher courses.

  19. Does labour epidural slow the progress of labour and lead to complications? Obstetricians′ perception working in private and public sector teaching hospitals in a developing country

    Directory of Open Access Journals (Sweden)

    Muhammad Sohaib

    2015-01-01

    Full Text Available Background and Aims: Obstetricians play a major role in the decision making for provision of analgesia for the woman in labour. As epidural analgesia (EA is the most preferred technique, it is important to know obstetricians′ perception regarding its effect on progress of labour and associated complications. Methods: The 6 months cross-sectional study included 114 obstetricians from teaching hospitals. After informed consent, obstetricians were asked to fill a predesigned questionnaire containing 13 close ended questions regarding their perception on the effect of EA on progress of labour, EA complications and whether they would recommend EA to their patients or not. Other variables included age, gender, training in EA, practice type and hospital settings (private or public sector. Results: Majority of the obstetricians had the perception of EA prolonging the first stage (89.5% and second stage (98.2% of labour, increasing the rate of caesarean section (87.7%, instrumental delivery (58.8% and increasing the incidence of backache (85.5%. None of the obstetricians received any formal training in EA. Majority (84.2% were not sure if they would recommend EA to their patients. When these responses were compared between public and private sector, a statistically higher percentage (P < 0.001 of public sector obstetricians had negative perception of EA. Conclusion: Perception of obstetrician regarding EA is contrary to the current evidence. There is a need to introduce formal curriculum on EA in obstetric training program and conduct regular refresher courses.

  20. Mother and adolescent expressed emotion and adolescent internalizing and externalizing symptom development : A six-year longitudinal study

    NARCIS (Netherlands)

    Hale, William W.; Crocetti, Elisabetta; Nelemans, Stefanie A.; Branje, Susan J. T.; van Lier, Pol A. C.; Koot, Hans M.; Meeus, W.H.J.

    2016-01-01

    In expressed emotion (EE) theory, it is held that high EE household environments enhance adolescent psychopathological distress. However, no longitudinal study has been conducted to examine if either the mother's EE or the adolescent's perception of EE predicts adolescent internalizing and

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