WorldWideScience

Sample records for early priming advances

  1. Early dynamics of the semantic priming shift

    Science.gov (United States)

    Lavigne, Frédéric; Chanquoy, Lucile; Dumercy, Laurent; Vitu, Françoise

    2013-01-01

    Semantic processing of sequences of words requires the cognitive system to keep several word meanings simultaneously activated in working memory with limited capacity. The real- time updating of the sequence of word meanings relies on dynamic changes in the associates to the words that are activated. Protocols involving two sequential primes report a semantic priming shift from larger priming of associates to the first prime to larger priming of associates to the second prime, in a range of long SOAs (stimulus-onset asynchronies) between the second prime and the target. However, the possibility for an early semantic priming shift is still to be tested, and its dynamics as a function of association strength remain unknown. Three multiple priming experiments are proposed that cross-manipulate association strength between each of two successive primes and a target, for different values of short SOAs and prime durations. Results show an early priming shift ranging from priming of associates to the first prime only to priming of strong associates to the first prime and all of the associates to the second prime. We investigated the neural basis of the early priming shift by using a network model of spike frequency adaptive cortical neurons (e.g., Deco & Rolls, 2005), able to code different association strengths between the primes and the target. The cortical network model provides a description of the early dynamics of the priming shift in terms of pro-active and retro-active interferences within populations of excitatory neurons regulated by fast and unselective inhibitory feedback. PMID:23717346

  2. Evidence for Early Morphological Decomposition: Combining Masked Priming with Magnetoencephalography

    Science.gov (United States)

    Lehtonen, Minna; Monahan, Philip J.; Poeppel, David

    2011-01-01

    Are words stored as morphologically structured representations? If so, when during word recognition are morphological pieces accessed? Recent masked priming studies support models that assume early decomposition of (potentially) morphologically complex words. The electrophysiological evidence, however, is inconsistent. We combined masked…

  3. Priming

    DEFF Research Database (Denmark)

    Conrath, Uwe; Beckers, Gerold J.M.; Flors, Victor

    2006-01-01

    Infection of plants by necrotizing pathogens or colonization of plant roots with certain beneficial microbes causes the induction of a unique physiological state called "priming." The primed state can also be induced by treatment of plants with various natural and synthetic compounds. Primed plants...... display either faster, stronger, or both activation of the various cellular defense responses that are induced following attack by either pathogens or insects or in response to abiotic stress. Although the phenomenon has been known for decades, most progress in our understanding of priming has been made...... over the past few years. Here, we summarize the current knowledge of priming in various induced-resistance phenomena in plants...

  4. Seed priming improves early seedling vigor, growth and productivity of spring maize

    Institute of Scientific and Technical Information of China (English)

    Hafeez ur Rehman; Hassan Iqbal; Shahzad M A Basra; Irfan Afzal; Muhammad Farooq; Abdul Wakeel; WANG Ning

    2015-01-01

    Potential of seed priming treatments in improving the performance of early planted maize was evaluated against timely planting. Seeds of maize hybrid FH-810 were soaked in water (hydropriming), CaCl2 (2.2%, osmopriming), moringa leaf extracts (MLE 3.3%, osmopriming) and salicylic acid (SA, 50 mg L–1, hormonal priming) each for 18 h. Untreated and hydroprimed seeds were taken as control. Seeds primed with SA took less time in emergence and had high vigor in early planted maize. Amongst treatments, hormonal priming, reduced the electrical conductivity, increased the leaf relative and chlorophyl contents fol owed by osmopriming with CaCl2 at seedling stage. Likewise, plant height, grain rows and 1 000-grain weight, grain and biological yield and harvest index were also improved by seed priming;however hormonal priming and osmopriming with MLE were more effective in this regard. Improved yield performance by hormonal priming or osmopriming with MLE in early planting primarily owed to increased leaf area index, crop growth and net assimilation rates, and maintenance of green leaf area at maturity. In conclusion, osmopriming with MLE and hormonal priming with SA were the most economical treatments in improving productivity of early planted spring maize through stimulation of early seedling growth at low temperature.

  5. Early, Equivalent ERP Masked Priming Effects for Regular and Irregular Morphology

    Science.gov (United States)

    Morris, Joanna; Stockall, Linnaea

    2012-01-01

    Converging evidence from behavioral masked priming (Rastle & Davis, 2008), EEG masked priming (Morris, Frank, Grainger, & Holcomb, 2007) and single word MEG (Zweig & Pylkkanen, 2008) experiments has provided robust support for a model of lexical processing which includes an early, automatic, visual word form based stage of morphological parsing…

  6. Early, Equivalent ERP Masked Priming Effects for Regular and Irregular Morphology

    Science.gov (United States)

    Morris, Joanna; Stockall, Linnaea

    2012-01-01

    Converging evidence from behavioral masked priming (Rastle & Davis, 2008), EEG masked priming (Morris, Frank, Grainger, & Holcomb, 2007) and single word MEG (Zweig & Pylkkanen, 2008) experiments has provided robust support for a model of lexical processing which includes an early, automatic, visual word form based stage of morphological parsing…

  7. Seed priming improves early seedling vigor, growth and productivity of spring maize

    Institute of Scientific and Technical Information of China (English)

    Hafeez ur Rehman[1; Hassan lqbal[1; Shahzad M A Basra[1; Irfan Afzal[1; Muhammad Farooq[2; Abdul Wakeel[3; WANG Ning[4

    2015-01-01

    Potential of seed priming treatments in improving the performance of early planted maize was evaluated against timely planting. Seeds of maize hybrid FH-810 were soaked in water (hydropriming), CaCI2 (2.2%, osmopriming), moringa leaf extracts (MLE 3.3%, osmopriming) and salicylic acid (SA, 50 mg L-1, hormonal priming) each for 18 h. Untreated and hydroprimed seeds were taken as control. Seeds primed with SA took less time in emergence and had high vigor in eady planted maize. Amongst treatments, hormonal priming, reduced the electrical conductivity, increased the leaf relative and chlorophyll contents followed by osmopriming with CaCI2 at seedling stage. Likewise, plant height, grain rows and 1 000-grain weight, grain and biological yield and harvest index were also improved by seed pdming; however hormonal priming and osmopriming with MLE were more effective in this regard. Improved yield performance by hormonal priming or osmopriming with MLE in early planting primarily owed to increased leaf area index, crop growth and net assimilation rates, and maintenance of green leaf area at maturity. In conclusion, osmopriming with MLE and hormonal priming with SA were the most economical treatments in improving productivity of early planted spring maize through stimulation of early seedling growth at low temperature.

  8. Emotional enhancement of perceptual priming is preserved in aging and early-stage Alzheimer's disease.

    Science.gov (United States)

    LaBar, Kevin S; Torpey, Dana C; Cook, Craig A; Johnson, Stephanie R; Warren, Lauren H; Burke, James R; Welsh-Bohmer, Kathleen A

    2005-01-01

    Perceptual priming for emotionally-negative and neutral scenes was tested in early-stage Alzheimer's disease (AD) patients and healthy younger, middle-aged and older adults. In the study phase, participants rated the scenes for their arousal properties. In the test phase, studied and novel scenes were initially presented subliminally, and the exposure duration was gradually increased until a valence categorization was made. The difference in exposure duration required to categorize novel versus studied items was the dependent measure of priming. Aversive content increased the magnitude of priming, an effect that was preserved in healthy aging and AD. Results from an immediate recognition memory test showed that the priming effects could not be attributable to enhanced explicit memory for the aversive scenes. These findings implicate a dissociation between the modulatory effect of emotion across implicit and explicit forms of memory in aging and early-stage AD.

  9. The temporal dynamics of early visual cortex involvement in behavioral priming.

    Directory of Open Access Journals (Sweden)

    Christianne Jacobs

    Full Text Available Transcranial magnetic stimulation (TMS allows for non-invasive interference with ongoing neural processing. Applied in a chronometric design over early visual cortex (EVC, TMS has proved valuable in indicating at which particular time point EVC must remain unperturbed for (conscious vision to be established. In the current study, we set out to examine the effect of EVC TMS across a broad range of time points, both before (pre-stimulus and after (post-stimulus the onset of symbolic visual stimuli. Behavioral priming studies have shown that the behavioral impact of a visual stimulus can be independent from its conscious perception, suggesting two independent neural signatures. To assess whether TMS-induced suppression of visual awareness can be dissociated from behavioral priming in the temporal domain, we thus implemented three different measures of visual processing, namely performance on a standard visual discrimination task, a subjective rating of stimulus visibility, and a visual priming task. To control for non-neural TMS effects, we performed electrooculographical recordings, placebo TMS (sham, and control site TMS (vertex. Our results suggest that, when considering the appropriate control data, the temporal pattern of EVC TMS disruption on visual discrimination, subjective awareness and behavioral priming are not dissociable. Instead, TMS to EVC disrupts visual perception holistically, both when applied before and after the onset of a visual stimulus. The current findings are discussed in light of their implications on models of visual awareness and (subliminal priming.

  10. The temporal dynamics of early visual cortex involvement in behavioral priming.

    Science.gov (United States)

    Jacobs, Christianne; de Graaf, Tom A; Goebel, Rainer; Sack, Alexander T

    2012-01-01

    Transcranial magnetic stimulation (TMS) allows for non-invasive interference with ongoing neural processing. Applied in a chronometric design over early visual cortex (EVC), TMS has proved valuable in indicating at which particular time point EVC must remain unperturbed for (conscious) vision to be established. In the current study, we set out to examine the effect of EVC TMS across a broad range of time points, both before (pre-stimulus) and after (post-stimulus) the onset of symbolic visual stimuli. Behavioral priming studies have shown that the behavioral impact of a visual stimulus can be independent from its conscious perception, suggesting two independent neural signatures. To assess whether TMS-induced suppression of visual awareness can be dissociated from behavioral priming in the temporal domain, we thus implemented three different measures of visual processing, namely performance on a standard visual discrimination task, a subjective rating of stimulus visibility, and a visual priming task. To control for non-neural TMS effects, we performed electrooculographical recordings, placebo TMS (sham), and control site TMS (vertex). Our results suggest that, when considering the appropriate control data, the temporal pattern of EVC TMS disruption on visual discrimination, subjective awareness and behavioral priming are not dissociable. Instead, TMS to EVC disrupts visual perception holistically, both when applied before and after the onset of a visual stimulus. The current findings are discussed in light of their implications on models of visual awareness and (subliminal) priming.

  11. Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time?

    Science.gov (United States)

    Chan, Tabitha Y; Tan, Poh Wee; Tang, Johann I

    2017-01-01

    Whole breast external beam radiotherapy (WBEBRT) is commonly used as an essential arm in the treatment management of women with early-stage breast cancer. Dosimetry planning for conventional WBEBRT typically involves a pair of tangential fields. Advancement in radiation technology and techniques has the potential to improve treatment outcomes with clinically meaningful long-term benefits. However, this advancement must be balanced with safety and improved efficacy. Intensity-modulated radiation therapy (IMRT) is an advanced technique that shows promise in improving the planning process and radiation delivery. Early data on utilizing IMRT for WBEBRT demonstrate more homogenous dose distribution with reduction in organs at risk doses. This translates to toxicities reduction. The two common descriptors for IMRT are forward-planning “fields in field” and inverse planning. Unlike IMRT for other organs, the aim of IMRT for breast planning is to achieve dose homogeneity and not organ conformality. The aim of this paper was to evaluate whether IMRT is ready for prime time based on these three points: 1) workload impact, 2) the clinical impact on the patient’s quality of life, and 3) the appropriateness and applicability to clinical practice.

  12. Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.

    Science.gov (United States)

    Johanns, Tanner M; Law, Calvin Y; Kalekar, Lokeshchandra A; O'Donnell, Hope; Ertelt, James M; Rowe, Jared H; Way, Sing Sing

    2011-04-01

    Typhoid fever is a systemic, persistent infection caused by host-specific strains of Salmonella. Although the use of antibiotics has reduced the complications associated with primary infection, recurrent infection remains an important cause of ongoing human morbidity and mortality. Herein, we investigated the impacts of antibiotic eradication of primary infection on protection against secondary recurrent infection. Using a murine model of persistent Salmonella infection, we demonstrate protection against recurrent infection is sustained despite early eradication of primary infection. In this model, protection is not mediated by CD4(+) or CD8(+) T cells because depletion of these cells either alone or in combination prior to rechallenge does not abrogate protection. Instead, infection followed by antibiotic-mediated clearance primes robust levels of Salmonella-specific antibody that can adoptively transfer protection to naïve mice. Thus, eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.

  13. Early priming minimizes the age-related immune compromise of CD8⁺ T cell diversity and function.

    Directory of Open Access Journals (Sweden)

    Sophie A Valkenburg

    2012-02-01

    Full Text Available The elderly are particularly susceptible to influenza A virus infections, with increased occurrence, disease severity and reduced vaccine efficacy attributed to declining immunity. Experimentally, the age-dependent decline in influenza-specific CD8(+ T cell responsiveness reflects both functional compromise and the emergence of 'repertoire holes' arising from the loss of low frequency clonotypes. In this study, we asked whether early priming limits the time-related attrition of immune competence. Though primary responses in aged mice were compromised, animals vaccinated at 6 weeks then challenged >20 months later had T-cell responses that were normal in magnitude. Both functional quality and the persistence of 'preferred' TCR clonotypes that expand in a characteristic immunodominance hierarchy were maintained following early priming. Similar to the early priming, vaccination at 22 months followed by challenge retained a response magnitude equivalent to young mice. However, late priming resulted in reduced TCRβ diversity in comparison with vaccination earlier in life. Thus, early priming was critical to maintaining individual and population-wide TCRβ diversity. In summary, early exposure leads to the long-term maintenance of memory T cells and thus preserves optimal, influenza-specific CD8(+ T-cell responsiveness and protects against the age-related attrition of naïve T-cell precursors. Our study supports development of vaccines that prime CD8(+ T-cells early in life to elicit the broadest possible spectrum of CD8(+ T-cell memory and preserve the magnitude, functionality and TCR usage of responding populations. In addition, our study provides the most comprehensive analysis of the aged (primary, secondary primed-early and secondary primed-late TCR repertoires published to date.

  14. Microglial priming and Alzheimer’s disease: a possible role for (early immune challenges and epigenetics?

    Directory of Open Access Journals (Sweden)

    Lianne Hoeijmakers

    2016-08-01

    Full Text Available Neuroinflammation is thought to contribute to Alzheimer’s disease (AD pathogenesis that is, to a large extent, mediated by microglia. Given the tight interaction between the immune system and the brain, peripheral immune challenges can profoundly affect brain function. Indeed, both preclinical and clinical studies have indicated that an aberrant inflammatory response can elicit behavioral impairments and cognitive deficits, especially when the brain is in a vulnerable state, e.g. during early development, as a result of aging, or under disease conditions like AD. However, how exactly peripheral immune challenges affect brain function and whether this is mediated by aberrant microglial functioning remains largely elusive. In this review, we hypothesize that; 1 systemic immune challenges occurring during vulnerable periods of life can increase the propensity to induce later cognitive dysfunction and accelerate AD pathology, and 2 that 'priming' of microglial cells is instrumental in mediating this vulnerability. We highlight how microglia can be primed by both neonatal infections as well as by aging, two periods of life during which microglial activity is known to be specifically upregulated. Lasting changes in (the ratios of specific microglial phenotypes can result in an exaggerated pro-inflammatory cytokine response to subsequent inflammatory challenges. While the resulting changes in brain function are initially transient, a continued and/or excess release of such pro-inflammatory cytokines can activate various downstream cellular cascades known to be relevant for AD. Finally, we discuss microglial priming and the aberrant microglial response as potential target for treatment strategies for AD.

  15. The early facilitatory effect of a peripheral spatially noninformative prime stimulus depends on target stimulus features

    Directory of Open Access Journals (Sweden)

    Azevedo E.L.

    2001-01-01

    Full Text Available We investigated the dependency of the early facilitatory effect of a prime stimulus (S1 on the physical characteristics of the target stimulus (S2. A go-no go reaction time paradigm was used. The S1 was a gray ring and the S2s were a white vertical line, a white horizontal line, a white cross and a white small ring, all inside a white ring with the same dimensions as the S1. S1 onset-S2 onset asynchrony was 100 ms. The stimuli appeared randomly in any one of the quadrants of a monitor screen. The S2 could occur at the same position as the S1 or at a different one. We observed a strong facilitatory effect when the vertical line or the horizontal line was the go stimulus and no effect when the cross was the go stimulus. These results show that the features of the target stimulus can be decisive for the appearance of the facilitatory effect of a peripheral spatially noninformative prime stimulus.

  16. The early facilitatory effect of a peripheral spatially noninformative prime stimulus depends on target stimulus features.

    Science.gov (United States)

    Azevedo, E L; Squella, S A; Ribeiro-do-Valle, L E

    2001-06-01

    We investigated the dependency of the early facilitatory effect of a prime stimulus (S1) on the physical characteristics of the target stimulus (S2). A go-no go reaction time paradigm was used. The S1 was a gray ring and the S2s were a white vertical line, a white horizontal line, a white cross and a white small ring, all inside a white ring with the same dimensions as the S1. S1 onset-S2 onset asynchrony was 100 ms. The stimuli appeared randomly in any one of the quadrants of a monitor screen. The S2 could occur at the same position as the S1 or at a different one. We observed a strong facilitatory effect when the vertical line or the horizontal line was the go stimulus and no effect when the cross was the go stimulus. These results show that the features of the target stimulus can be decisive for the appearance of the facilitatory effect of a peripheral spatially noninformative prime stimulus.

  17. Prime Knowledge about Primes

    Science.gov (United States)

    Eisenberg, Theodore

    2007-01-01

    Several proofs demonstrating that there are infinitely many primes, different types of primes, tests of primality, pseudo primes, prime number generators and open questions about primes are discussed in Section 1. Some of these notions are elaborated upon in Section 2, with discussions of the Riemann zeta function and how algorithmic complexity…

  18. Prime Slaughter

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2011-01-01

    Starting from the difficulty of creating playful representation of domain-specific abstract concepts, this study discusses the design of Prime Slaughter, a computer game aimed at facilitating individual sense-making of abstract mathematical concepts. Specifically the game proposes a transposition...... of primality and factorization into playful interactions, addressed to primary and early secondary school children. Taking into account individual needs expressed by children regarding play, during a participatory design processes aimed at enhancing learning in museums, Prime Slaughter allows for multiple...

  19. Prime Slaughter

    DEFF Research Database (Denmark)

    Valente, Andrea; Marchetti, Emanuela

    2011-01-01

    Starting from the difficulty of creating playful representation of domain-specific abstract concepts, this study discusses the design of Prime Slaughter, a computer game aimed at facilitating individual sense-making of abstract mathematical concepts. Specifically the game proposes a transposition...... of primality and factorization into playful interactions, addressed to primary and early secondary school children. Taking into account individual needs expressed by children regarding play, during a participatory design processes aimed at enhancing learning in museums, Prime Slaughter allows for multiple...

  20. Early-life Stress Impacts the Developing Hippocampus and Primes Seizure Occurrence: cellular, molecular, and epigenetic mechanisms

    Directory of Open Access Journals (Sweden)

    Li-Tung eHuang

    2014-02-01

    Full Text Available Early-life stress includes prenatal, postnatal, and adolescence stress. Early-life stress can affect the development of the hypothalamic-pituitary-adrenal (HPA axis, and cause cellular and molecular changes in the developing hippocampus that can result in neurobehavioral changes later in life. Epidemiological data implicate stress as a cause of seizures in both children and adults. Emerging evidence indicates that both prenatal and postnatal stress can prime the developing brain for seizures and an increase in epileptogenesis. This article reviews the cellular and molecular changes encountered during prenatal and postnatal stress, and assesses the possible link between these changes and increases in seizure occurrence and epileptogenesis in the developing hippocampus. In addititon, the priming effect of prenatal and postnatal stress for seizures and epileptogenesis is discussed. Finally, the roles of epigenetic modifications in hippocampus and HPA axis programming, early-life stress, and epilepsy are discussed.

  1. Early Exposures to Ecogenomics: Effects of Priming and Web Site Interactivity Among Adolescents

    NARCIS (Netherlands)

    Bos, Mark J.W.; Koolstra, Cees M.; Willems, J.T.J.M.

    2010-01-01

    In the context of public introductions to emerging technologies, this study examined effects of priming and Web site interactivity on adolescents’ attitude development and information processing. In a four (priming) by three (interactivity levels) experiment, participants (N = 273) were required to

  2. Effect of local allergen priming on early, late, delayed-phase, and epicutaneous skin reactions

    NARCIS (Netherlands)

    Weller, FR; Weller, MS; Jansen, HM; deMonchy, JGR

    1996-01-01

    Allergic disease is renected in a chronic inflammatory response to an allergen. It is thought that local allergen priming underlies this chronicity. To assess the effect of allergen priming on the amplitude and histologic effect of the allergic reaction, four sequential, intracutaneous skin tests we

  3. Early effects of emotion on word immediate repetition priming: electrophysiological and source localization evidence.

    Science.gov (United States)

    Méndez-Bértolo, Constantino; Pozo, Miguel A; Hinojosa, José A

    2011-12-01

    The processing of a stimulus benefits from the previous exposure of an identical stimulus, which is known as immediate repetition priming (IRP). Although several experimental manipulations modulate the size of this effect, the influence of affective information is still unclear. In order to explore the temporo-spatial characteristics of the interaction between emotion and IRP, event-related potentials (ERPs) to negative and neutral target words were measured during a lexical decision task in an IRP paradigm. Temporal and spatial versions of principal components analyses were used to detect and quantify those ERP components associated with IRP. A source localization procedure provided information on the neural origin of these components. Behavioural analyses showed that reaction times to repeated negative and neutral words differed from those to unrepeated negative and neutral words, respectively. However, the interaction between repetition and emotion was only marginally significant. In contrast, ERP analyses revealed specific IRP effects for negative words: Repeated negative words elicited reduced P120/enhanced N170 effects and weaker activation suppression in the left inferior frontal gyrus than did unrepeated negative words. These results suggest that a word's negative content captures attention interfering with IRP mechanisms, possibly at an early semantic stage of processing.

  4. Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

    Science.gov (United States)

    Ng, Ashley P; Hu, Yifang; Metcalf, Donald; Hyland, Craig D; Ierino, Helen; Phipson, Belinda; Wu, Di; Baldwin, Tracey M; Kauppi, Maria; Kiu, Hiu; Di Rago, Ladina; Hilton, Douglas J; Smyth, Gordon K; Alexander, Warren S

    2015-05-01

    Down syndrome (DS), with trisomy of chromosome 21 (HSA21), is the commonest human aneuploidy. Pre-leukemic myeloproliferative changes in DS foetal livers precede the acquisition of GATA1 mutations, transient myeloproliferative disorder (DS-TMD) and acute megakaryocytic leukemia (DS-AMKL). Trisomy of the Erg gene is required for myeloproliferation in the Ts(1716)65Dn DS mouse model. We demonstrate here that genetic changes specifically attributable to trisomy of Erg lead to lineage priming of primitive and early multipotential progenitor cells in Ts(1716)65Dn mice, excess megakaryocyte-erythroid progenitors, and malignant myeloproliferation. Gene expression changes dependent on trisomy of Erg in Ts(1716)65Dn multilineage progenitor cells were correlated with those associated with trisomy of HSA21 in human DS hematopoietic stem and primitive progenitor cells. These data suggest a role for ERG as a regulator of hematopoietic lineage potential, and that trisomy of ERG in the context of DS foetal liver hemopoiesis drives the pre-leukemic changes that predispose to subsequent DS-TMD and DS-AMKL.

  5. Effects of Part- and Whole-Object Primes on Early MEG Responses to Mooney Faces and Houses.

    Science.gov (United States)

    Steinberg Lowe, Mara; Lewis, Gwyneth A; Poeppel, David

    2016-01-01

    Results from neurophysiological experiments suggest that face recognition engages a sensitive mechanism that is reflected in increased amplitude and decreased latency of the MEG M170 response compared to non-face visual targets. Furthermore, whereas recognition of objects (e.g., houses) has been argued to be based on individual features (e.g., door, window), face recognition may depend more on holistic information. Here we analyzed priming effects of component and holistic primes on 20 participants' early MEG responses to two-tone (Mooney) images to determine whether face recognition in this context engages "featural" or "configural" processing. Although visually underspecified, the Mooney images in this study elicited M170 responses that replicate the typical face vs. house effect. However, we found a distinction between holistic vs. component primes that modulated this effect dependent upon compatibility (match) between the prime and target. The facilitatory effect of holistic faces and houses for Mooney faces and houses, respectively, suggests that both Mooney face and house recognition-both low spatial frequency stimuli-are based on holistic information.

  6. Rutin-Mediated Priming of Plant Resistance to Three Bacterial Pathogens Initiating the Early SA Signal Pathway.

    Directory of Open Access Journals (Sweden)

    Wei Yang

    Full Text Available Flavonoids are ubiquitous in the plant kingdom and have many diverse functions, including UV protection, auxin transport inhibition, allelopathy, flower coloring and insect resistance. Here we show that rutin, a proud member of the flavonoid family, could be functional as an activator to improve plant disease resistances. Three plant species pretreated with 2 mM rutin were found to enhance resistance to Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Pseudomonas syringae pv. tomato strain DC3000 in rice, tobacco and Arabidopsis thaliana respectively. While they were normally propagated on the cultural medium supplemented with 2 mM rutin for those pathogenic bacteria. The enhanced resistance was associated with primed expression of several pathogenesis-related genes. We also demonstrated that the rutin-mediated priming resistance was attenuated in npr1, eds1, eds5, pad4-1, ndr1 mutants, and NahG transgenic Arabidopsis plant, while not in either snc1-11, ein2-5 or jar1 mutants. We concluded that the rutin-priming defense signal was modulated by the salicylic acid (SA-dependent pathway from an early stage upstream of NDR1 and EDS1.

  7. Rutin-Mediated Priming of Plant Resistance to Three Bacterial Pathogens Initiating the Early SA Signal Pathway.

    Science.gov (United States)

    Yang, Wei; Xu, Xiaonan; Li, Yang; Wang, Yingzi; Li, Ming; Wang, Yong; Ding, Xinhua; Chu, Zhaohui

    2016-01-01

    Flavonoids are ubiquitous in the plant kingdom and have many diverse functions, including UV protection, auxin transport inhibition, allelopathy, flower coloring and insect resistance. Here we show that rutin, a proud member of the flavonoid family, could be functional as an activator to improve plant disease resistances. Three plant species pretreated with 2 mM rutin were found to enhance resistance to Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Pseudomonas syringae pv. tomato strain DC3000 in rice, tobacco and Arabidopsis thaliana respectively. While they were normally propagated on the cultural medium supplemented with 2 mM rutin for those pathogenic bacteria. The enhanced resistance was associated with primed expression of several pathogenesis-related genes. We also demonstrated that the rutin-mediated priming resistance was attenuated in npr1, eds1, eds5, pad4-1, ndr1 mutants, and NahG transgenic Arabidopsis plant, while not in either snc1-11, ein2-5 or jar1 mutants. We concluded that the rutin-priming defense signal was modulated by the salicylic acid (SA)-dependent pathway from an early stage upstream of NDR1 and EDS1.

  8. Reading aloud in Persian: ERP evidence for an early locus of the masked onset priming effect.

    Science.gov (United States)

    Timmer, Kalinka; Vahid-Gharavi, Narges; Schiller, Niels O

    2012-07-01

    The current study investigates reading aloud words in Persian, a language that does not mark all its vowels in the script. Behaviorally, a masked onset priming effect (MOPE) was revealed for transparent words, with faster speech onset latencies in the phoneme-matching condition (i.e. phonological prime and target onset overlap; e.g. [symbol: see text] /sɒːl/; 'year' [symbol: see text] /sot/; 'voice') than the phoneme-mismatching condition (e.g. [symbol: see text] /tɒːb/ 'swing' - [symbol: see text] /sot/; 'voice'). For opaque target words (e.g. [symbol: see text] /solh/; 'peace'), no such effect was found. However, event-related potentials (ERPs) did reveal an amplitude difference between the two prime conditions in the 80-160 ms time window for transparent as well as opaque words. Only for the former, this effect continued into the 300-480 ms time window. This finding constrains the time course of the MOPE and suggests the simultaneous activation of both the non-lexical grapheme-to-phoneme and the lexical route in the dual-route cascaded (DRC) model. Copyright © 2012 Elsevier Inc. All rights reserved.

  9. G-CSF priming, clofarabine, and high dose cytarabine (GCLAC) for upfront treatment of acute myeloid leukemia, advanced myelodysplastic syndrome or advanced myeloproliferative neoplasm.

    Science.gov (United States)

    Becker, Pamela S; Medeiros, Bruno C; Stein, Anthony S; Othus, Megan; Appelbaum, Frederick R; Forman, Stephen J; Scott, Bart L; Hendrie, Paul C; Gardner, Kelda M; Pagel, John M; Walter, Roland B; Parks, Cynthia; Wood, Brent L; Abkowitz, Janis L; Estey, Elihu H

    2015-04-01

    Prior study of the combination of clofarabine and high dose cytarabine with granulocyte colony-stimulating factor (G-CSF) priming (GCLAC) in relapsed or refractory acute myeloid leukemia resulted in a 46% rate of complete remission despite unfavorable risk cytogenetics. A multivariate analysis demonstrated that the remission rate and survival with GCLAC were superior to FLAG (fludarabine, cytarabine, G-CSF) in the relapsed setting. We therefore initiated a study of the GCLAC regimen in the upfront setting in a multicenter trial. The objectives were to evaluate the rates of complete remission (CR), overall and relapse-free survival (OS and RFS), and toxicity of GCLAC. Clofarabine was administered at 30 mg m(-2) day(-1) × 5 and cytarabine at 2 g m(-2) day(-1) × 5 after G-CSF priming in 50 newly-diagnosed patients ages 18-64 with AML or advanced myelodysplastic syndrome (MDS) or advanced myeloproliferative neoplasm (MPN). Responses were assessed in the different cytogenetic risk groups and in patients with antecedent hematologic disorder. The overall CR rate was 76% (95% confidence interval [CI] 64-88%) and the CR + CRp (CR with incomplete platelet count recovery) was 82% (95% CI 71-93%). The CR rate was 100% for patients with favorable, 84% for those with intermediate, and 62% for those with unfavorable risk cytogenetics. For patients with an antecedent hematologic disorder (AHD), the CR rate was 65%, compared to 85% for those without an AHD. The 60 day mortality was 2%. Thus, front line GCLAC is a well-tolerated, effective induction regimen for AML and advanced myelodysplastic or myeloproliferative disorders.

  10. Brain potentials reveal semantic priming in both the 'active' and the 'non-attended' language of early bilinguals.

    Science.gov (United States)

    Martin, Clara D; Dering, Benjamin; Thomas, Enlli M; Thierry, Guillaume

    2009-08-01

    A key question in the study of bilingual functioning is whether both the languages known are active at all times or whether one language can be selectively inactivated when bilingual individuals are tuned to the other language. Psycholinguistic and neuroscientific investigations have provided inconsistent data regarding the level of semantic activation of the two languages, even in the case of highly proficient bilinguals. In the present study, highly proficient, early Welsh/English bilinguals were presented with words in both their languages and were required to make word length decisions on words in one language while disregarding words in the other. Participants were not explicitly told about the organization of the word stream in pairs manipulating (a) semantic relatedness, (b) language of the prime and (c) language of the target in a fully counterbalanced two-by-two-by-two design. We observed significant semantic priming for both English and Welsh target words, irrespective of the active language, and independent of performance in the low-level letter counting task. We conclude that accessing the meaning of a written word is automatic in the two languages even when fluent bilingual adults are instructed to disregard words in one of their languages.

  11. When the zebra loses its stripes: Semantic priming in early Alzheimer's disease and semantic dementia.

    Science.gov (United States)

    Laisney, Mickaël; Giffard, Bénédicte; Belliard, Serge; de la Sayette, Vincent; Desgranges, Béatrice; Eustache, Francis

    2011-01-01

    Patients suffering from Alzheimer's disease (AD) or semantic dementia (SD) both exhibit deficits on explicit tasks of semantic memory. Semantic priming (SP) paradigms provide a very pure and precise implicit measurement of semantic memory impairment, and a previous study of AD (Giffard et al., 2002) using one such paradigm revealed that AD patients in the initial stages of semantic deterioration presented an abnormally large priming effect (hyperpriming) in a category-coordinate condition, compared with controls. This astonishing phenomenon could stem from the specific loss of distinctive attributes that make it possible to distinguish between semantically close concepts, while attributes shared by different concepts belonging to a given category remain intact. To test this hypothesis and compare the degradation of semantic memory in AD and SD, we devised an SP paradigm in which word pairs had either a category-coordinate or an attribute relationship. In accordance with our hypothesis, we distinguished between shared (duck-feathers) versus distinctive attributes (zebra-stripes) and close (tiger-lion) versus distant (elephant-crocodile) category-coordinate relationships. This paradigm, together with two explicit semantic memory tasks (picture-naming and categorization), was administered to 16 AD and 8 SD patients and 30 elderly control subjects. The AD patients, at the very beginning of semantic deterioration, only displayed impaired SP effects in the distinctive attribute condition, whereas in the SD patients, who had more severe semantic deterioration, we observed an extinction of SP effects in both attribute conditions. In SD patients, we also report hyperpriming effects in both category-coordinate conditions. Our results suggest that semantic memory impairment follows the same course in both AD and SD, affecting distinctive attributes first and then shared ones. In accordance with distributed models of semantic memory, the loss of distinctive attributes leads

  12. Seed Priming Influence on Early Crop Growth, Phenological Development and Yield Performance of Linola (Linum usitatissimum L.)

    Institute of Scientific and Technical Information of China (English)

    Hafeez ur Rehman; Muhammad Qaiser Nawaz; Shahzad Maqsood Ahmed Basra; Irfan Afzal; Azra Yasmeen; Fayyaz ul-Hassan

    2014-01-01

    Reduced early crop growth and limited branching are amongst yield limiting factors of linola. Field response of seed priming treatments viz. 50 mmol L-1 salicylic acid (SA), 2.2%CaCl2 and 3.3%moringa leaf extract (MLE) including untreated dry and hydropriming controls was evaluated on early crop growth and yield performance of linola. Osmopriming with CaCl2 reduced emergence time and produced the highest seedling fresh and dry weights including Chl. a contents. Osmopriming with CaCl2 reduced crop branching and lfowering and maturity times and had the maximum plant height, number of branches, tillers, pods and seeds per pod followed by MLE. Increase in seed weight, biological and seed yields was 9.30, 34.16 and 39.49%, harvest index (4.12%) and oil contents (13.39%) for CaCl2 osmopriming. Positive relationship between emergence and seedling vigor traits, 100-seed weight, seed yield with maturity time, 100-seed weight and seed yield were found. The study concludes that seed osmopriming with CaCl2 or MLE can play signiifcant role to improve early crop growth and seed yields of linola.

  13. The Advanced Photon Source: Performance and results from early operation

    Energy Technology Data Exchange (ETDEWEB)

    Moncton, D.E. [Argonne National Lab., IL (United States). Advanced Photon Source

    1997-10-01

    The Advanced Photon Source at Argonne National Laboratory is now providing researchers with extreme-brilliance undulator radiation in the hard x-ray region of the spectrum. All technical facilities and components are operational and have met design specifications. Fourteen research teams, occupying 20 sectors on the APS experiment hall floor, are currently installing beamline instrumentation or actively taking data. An overview is presented for the first operational years of the Advanced Photon Source. Emphasis is on the performance of accelerators and insertion devices, as well as early scientific results and future plans.

  14. Honour and Fighting Social Advancement in the Early Modern Age

    Directory of Open Access Journals (Sweden)

    Gassmann Jürg

    2015-05-01

    Full Text Available The article considers the importance of military service in social advancement, here understood as filling the role of “prince” in feudal law and thus participating in the government of an estate, in the transition from the Late Middle Ages to the Renaissance or Early Modern Age. In the context of a city burgher or a petty noble or knight advancing into a government role, did honour require that the individual have experience in fighting – in war, military organisation and leadership? How did mercenaries figure? What role, if any, did Fechtmeister, Fechtbücher, Fechtschulen or Kriegsbücher play?

  15. How Streptomyces anulatus Primes Grapevine Defenses to Cope with Gray Mold: A Study of the Early Responses of Cell Suspensions

    Directory of Open Access Journals (Sweden)

    Parul Vatsa-Portugal

    2017-06-01

    Full Text Available Gray mold, caused by Botrytis cinerea, is one of the most destructive diseases of grapevine and is controlled with an intense application of fungicides. As alternatives to chemicals, beneficial microbes may promote plant health by stimulating the plant’s immune system. An actinomycete, Streptomyces anulatus S37, has been screened from the rhizosphere microbiome of healthy Vitis vinifera on the basis of its ability to promote grapevine growth and to induce resistance against various phytopathogens, including B. cinerea. However, molecular mechanisms involved locally after direct perception of these bacteria by plant cells still remain unknown. This study focuses on local defense events induced in grapevine cells during interactions with S. anulatus S37 before and after pathogen challenge. We demonstrated that S. anulatus S37 induced early responses including oxidative burst, extracellular alkalinization, activation of protein kinases, induction of defense gene expression and phytoalexin accumulation, but not the programmed cell death. Interestingly, upon challenge with the B. cinerea, the S. anulatus S37 primed grapevine cells for enhanced defense reactions with a decline in cell death. In the presence of the EGTA, a calcium channel inhibitor, the induced oxidative burst, and the protein kinase activity were inhibited, but not the extracellular alkalinization, suggesting that Ca2+ may also contribute upstream to the induced defenses. Moreover, desensitization assays using extracellular pH showed that once increased by S. anulatus S37, cells became refractory to further stimulation by B. cinerea, suggesting that grapevine cells perceive distinctly beneficial and pathogenic microbes.

  16. Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5+ Intestinal Stem Cells

    Directory of Open Access Journals (Sweden)

    Tae-Hee Kim

    2016-08-01

    Full Text Available Lgr5+ intestinal stem cells (ISCs drive epithelial self-renewal, and their immediate progeny—intestinal bipotential progenitors—produce absorptive and secretory lineages via lateral inhibition. To define features of early transit from the ISC compartment, we used a microfluidics approach to measure selected stem- and lineage-specific transcripts in single Lgr5+ cells. We identified two distinct cell populations, one that expresses known ISC markers and a second, abundant population that simultaneously expresses markers of stem and mature absorptive and secretory cells. Single-molecule mRNA in situ hybridization and immunofluorescence verified expression of lineage-restricted genes in a subset of Lgr5+ cells in vivo. Transcriptional network analysis revealed that one group of Lgr5+ cells arises from the other and displays characteristics expected of bipotential progenitors, including activation of Notch ligand and cell-cycle-inhibitor genes. These findings define the earliest steps in ISC differentiation and reveal multilineage gene priming as a fundamental property of the process.

  17. Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner.

    Science.gov (United States)

    Viviani, Barbara; Boraso, Mariaserena; Valero, Manuel; Gardoni, Fabrizio; Marco, Eva Maria; Llorente, Ricardo; Corsini, Emanuela; Galli, Corrado Lodovico; Di Luca, Monica; Marinovich, Marina; López-Gallardo, Meritxell; Viveros, Maria-Paz

    2014-01-01

    Challenges experienced in early life cause an enduring phenotypical shift of immune cells towards a sensitised state that may lead to an exacerbated reaction later in life and contribute to increased vulnerability to neurological diseases. Peripheral and central inflammation may affect neuronal function through cytokines such as IL-1. The extent to which an early life challenge induces long-term alteration of immune receptors organization in neurons has not been shown. We investigated whether a single episode of maternal deprivation (MD) on post-natal day (PND) 9 affects: (i) the synapse distribution of IL-1RI together with subunits of NMDA and AMPA receptors; and (ii) the interactions between IL-1RI and the GluN2B subunit of the NMDAR in the long-term, at PND 45. MD increased IL-1RI levels and IL-1RI interactions with GluN2B at the synapse of male hippocampal neurons, without affecting the total number of IL-1RI or NMDAR subunits. Although GluN2B and GluN2A were slightly but not significantly changed at the synapse, their ratio was significantly decreased in the hippocampus of the male rats who had experienced MD; the levels of the GluA1 and GluA2 subunits of the AMPAR were also decreased. These changes were not observed immediately after the MD episode. None of the observed alterations occurred in the hippocampus of the females or in the prefrontal cortex of either sex. These data reveal a long-term, sex-dependent modification in receptor organisation at the hippocampal post-synapses following MD. We suggest that this effect might contribute to priming hippocampal synapses to the action of IL-1β.

  18. Treatment strategies in early and advanced Parkinson disease.

    Science.gov (United States)

    Ossig, Christiana; Reichmann, Heinz

    2015-02-01

    The initiation of therapy in Parkinson disease (PD), altering the medication, adding new substances, and switching to alternative therapies throughout the disease is always a matter of debate. In the past, experts in PD have propagated different medication strategies. Even though there is no new medical treatment on the horizon, much has changed in consideration of the known treatments in the early and advanced therapy for PD. Therapeutic regimens have to be adapted and adjusted on a regular basis to accomplish the best medical care for the predominant symptom of the individual patient with PD. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. [Mechanism of tomato plants enhanced disease resistance against early blight primed by arbuscular mycorrhizal fungus Glomus versiforme].

    Science.gov (United States)

    Song, Yuan-yuan; Wang, Rui-long; Wei, Xiao-chen; Lu, Yong-jian; Tang, Zhao-yang; Wu, Guo-zhao; Su, Yi-juan; Zeng, Ren-sen

    2011-09-01

    Arbuscular mycorrhiza (AM) can not only improve host plants nutrient absorption, but also enhance their disease resistance. Taking the tomato (Lycopersicon esculentum) seedlings preinoculated with axbuscular mycorrhizal fungus (AMF) Glomus versiforme as test materials, this paper studied their protective enzyme activities and defense-related genes expression, and their resistance against a fungal pathogen Alternaria solani Sorauer which causes early blight. The seedlings pre-inoculated with AMF and later inoculated with A. solani showed significantly higher activities of superoxide dismutase (SOD) and peroxidase (POD) in leaves. The leaf SOD activity of the dually inoculated plants reached the maximum 18 h after pathogen inoculation, being 28.6%, 79.2% and 82.8% higher than that of the plants with G. versiforme inoculation alone, pathogen inoculation alone, and non-inoculation, and the Leaf POD activity reached the maximum 65 h after pathogen inoculation, being 762%, 18.3%, and 1710% higher, respectively. Real time RT-PCR analysis showed that dual inoculation with C. versiforme and A. solani strongly induced the expression of three defense-related genes. The transcript levels of pathogen-related protein (PR1), basic type beta-1,3-glucanase (PR-2), and chitinase (PR-3) in leaves were 9.67-, 8.54-, and 13.4-fold higher, as compared with the non-inoculation control, respectively. Bioassay showed that the disease incidence and disease index of the seedlings pre-inoculated with C. versiforme were reduced by 36.3% and 61.4%, respectively, as compared with the non-mycorrhizal control plants. These findings indicated that mycorrhizal colonization could induce stronger and quicker defense responses of host tomato plants, and priming could be an important mechanism of the enhanced disease resistance of mycorrhizal tomato plants.

  20. Advances in early diagnosis and therapy of pancreatic cancer

    Institute of Scientific and Technical Information of China (English)

    Qiang Xu; Tai-Ping Zhang; Yu-Pei Zhao

    2011-01-01

    BACKGROUND: Pancreatic cancer remains a devastating disease with a 5-year survival rate of less than 5%. Recent advances in diagnostic methods and therapeutic approaches have increased the possibility of improving the existing poor prognosis. DATA  SOURCES: English-language articles reporting early diagnosis and therapy of pancreatic cancer were searched from the MEDLINE and PubMed databases, Chinese-language articleswerefromCHKD(ChinaHospitalKnowledgeDatabase). RESULT: The current literature about pancreatic cancer was reviewed from three aspects: statistics, screening and early detection, and therapy. CONCLUSIONS: Early detection and screening of pancreatic cancer currently should be limited to high risk patients. Surgical resection is the only curative approach available, with some recent improvement in outcomes. Gemcitabine has been a standard treatment during the last decade. Gemcitabine-based combination treatment, especially combined with newer molecular targeted agents, is promising. The rationale for radiotherapy is controversial, but with the recent development of modern radiation delivery techniques, radiotherapy should be intensified. Patients with borderline pancreatic cancer could benefit from neoadjuvant therapy but more evidence is needed and the best neoadjuvant regimen is still to be determined.

  1. Advances in the microbial etiology and pathogenesis of early childhood caries.

    Science.gov (United States)

    Hajishengallis, E; Parsaei, Y; Klein, M I; Koo, H

    2017-02-01

    Early childhood caries (ECC) is one of the most prevalent infectious diseases affecting children worldwide. ECC is an aggressive form of dental caries, which, left untreated, can result in rapid and extensive cavitation in teeth (rampant caries) that is painful and costly to treat. Furthermore, it affects mostly children from impoverished backgrounds, and so constitutes a major challenge in public health. The disease is a prime example of the consequences arising from complex, dynamic interactions between microorganisms, host, and diet, leading to the establishment of highly pathogenic (cariogenic) biofilms. To date, there are no effective methods to identify those at risk of developing ECC or to control the disease in affected children. Recent advances in deep-sequencing technologies, novel imaging methods, and (meta)proteomics-metabolomics approaches provide an unparalleled potential to reveal new insights to illuminate our current understanding about the etiology and pathogenesis of the disease. In this concise review, we provide a broader perspective about the etiology and pathogenesis of ECC based on previous and current knowledge on biofilm matrix, microbial diversity, and host-microbe interactions, which could have direct implications for developing new approaches for improved risk assessment and prevention of this devastating and costly childhood health condition. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  2. Exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer.

    Science.gov (United States)

    Kang, Guhyun; Hwang, Woo Cheol; Do, In-Gu; Wang, Kai; Kang, So Young; Lee, Jeeyun; Park, Se Hoon; Park, Joon Oh; Kang, Won Ki; Jang, Jiryeon; Choi, Min-Gew; Lee, Jun Ho; Sohn, Tae Sung; Bae, Jae Moon; Kim, Sung; Kim, Min Ji; Kim, Seonwoo; Park, Cheol Keun; Kim, Kyoung-Mee

    2013-01-01

    Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes) and AGCs (3104 genes). A higher frequency of C>G transitions was observed in intestinal-type compared to diffuse-type carcinomas (P = 0.010). The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.

  3. mRNA Structural constraints on EBNA1 synthesis impact on in vivo antigen presentation and early priming of CD8+ T cells.

    Directory of Open Access Journals (Sweden)

    Judy T Tellam

    2014-10-01

    Full Text Available Recent studies have shown that virally encoded mRNA sequences of genome maintenance proteins from herpesviruses contain clusters of unusual structural elements, G-quadruplexes, which modulate viral protein synthesis. Destabilization of these G-quadruplexes can override the inhibitory effect on self-synthesis of these proteins. Here we show that the purine-rich repetitive mRNA sequence of Epstein-Barr virus encoded nuclear antigen 1 (EBNA1 comprising G-quadruplex structures, limits both the presentation of MHC class I-restricted CD8(+ T cell epitopes by CD11c(+ dendritic cells in draining lymph nodes and early priming of antigen-specific CD8(+ T-cells. Destabilization of the G-quadruplex structures through codon-modification significantly enhanced in vivo antigen presentation and activation of virus-specific T cells. Ex vivo imaging of draining lymph nodes by confocal microscopy revealed enhanced antigen-specific T-cell trafficking and APC-CD8(+ T-cell interactions in mice primed with viral vectors encoding a codon-modified EBNA1 protein. More importantly, these antigen-specific T cells displayed enhanced expression of the T-box transcription factor and superior polyfunctionality consistent with the qualitative impact of translation efficiency. These results provide an important insight into how viruses exploit mRNA structure to down regulate synthesis of their viral maintenance proteins and delay priming of antigen-specific T cells, thereby establishing a successful latent infection in vivo. Furthermore, targeting EBNA1 mRNA rather than protein by small molecules or antisense oligonucleotides will enhance EBNA1 synthesis and the early priming of effector T cells, to establish a more rapid immune response and prevent persistent infection.

  4. Exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer.

    Directory of Open Access Journals (Sweden)

    Guhyun Kang

    Full Text Available Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC, whereas the prognosis of patients with advanced gastric cancer (AGC remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes and AGCs (3104 genes. A higher frequency of C>G transitions was observed in intestinal-type compared to diffuse-type carcinomas (P = 0.010. The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.

  5. Early-onset age-related changes in dendritic cell subsets can impair antigen-specific T helper 1 (Th1) CD4 T cell priming.

    Science.gov (United States)

    Farazi, Michelle; Cohn, Zachary; Nguyen, Justine; Weinberg, Andrew D; Ruby, Carl E

    2014-08-01

    Decline in CD4 T cell immune responses is associated with aging. Although a number of immunological defects have been identified in elderly mice (>18 months old), a key early-onset immune defect at middle age could be a driver or contributor to defective CD4 T cell responses. Our studies demonstrate that age-related alterations in DC subsets within the priming environment of middle-aged mice (12 months old) correlate with and can directly contribute to decreases in antigen-specific CD4 T cell Th1 differentiation, which measured by T-bet and IFN-γ expression, was decreased significantly in T cells following VSV infection or s.c. immunization with a protein antigen in the context of immune stimulation via OX40. The deficient Th1 phenotype, observed following protein antigen challenge, was found to be the result of an age-related decrease in an inflammatory DC subset (CD11b+ Gr-1/Ly6C+) in the dLN that corresponded with T cell dysfunction. In the virus model, we observed significant changes in two DC subsets: mDCs and pDCs. Thus, different, early age-related changes in the DC profile in the priming environment can significantly contribute to impaired Th1 differentiation, depending on the type of immunological challenge. © 2014 Society for Leukocyte Biology.

  6. A priming dose of protons alters the early cardiac cellular and molecular response to 56Fe irradiation

    Science.gov (United States)

    Ramadan, Samy S.; Sridharan, Vijayalakshmi; Koturbash, Igor; Miousse, Isabelle R.; Hauer-Jensen, Martin; Nelson, Gregory A.; Boerma, Marjan

    2016-02-01

    Purpose: Recent evidence suggests that the heart may be injured by ionizing radiation at lower doses than was previously thought. This raises concerns about the cardiovascular risks from exposure to radiation during space travel. Since space travel is associated with exposure to both protons from solar particle events and heavy ions from galactic cosmic rays, we here examined the effects of a "priming" dose of protons on the cardiac cellular and molecular response to a "challenge" dose of 56Fe in a mouse model. Methods: Male C57BL/6 mice at 10 weeks of age were exposed to sham-irradiation, 0.1 Gy of protons (150 MeV), 0.5 Gy of 56Fe (600 MeV/n), or 0.1 Gy of protons 24 hours prior to 0.5 Gy of 56Fe. Hearts were obtained at 7 days post-irradiation and western-blots were used to determine protein markers of cardiac remodeling, inflammatory infiltration, and cell death. Results: Exposure to 56Fe caused an increase in expression of α-smooth muscle cell actin, collagen type III, the inflammatory cell markers mast cell tryptase, CD2 and CD68, the endothelial glycoprotein thrombomodulin, and cleaved caspase 3. Of all proteins investigated, protons at a dose of 0.1 Gy induced a small increase only in cleaved caspase 3 levels. On the other hand, exposure to protons 24 hours before 56Fe prevented all of the responses to 56Fe. Conclusions: This study shows that a low dose of protons may prime the heart to respond differently to a subsequent challenge dose of heavy ions. Further investigation is required to identify responses at additional time points, consequences for cardiac function, threshold dose levels, and mechanisms by which a proton priming dose may alter the response to heavy ions.

  7. The Advanced Technology Solar Telescope: design and early construction

    Science.gov (United States)

    McMullin, Joseph P.; Rimmele, Thomas R.; Keil, Stephen L.; Warner, Mark; Barden, Samuel; Bulau, Scott; Craig, Simon; Goodrich, Bret; Hansen, Eric; Hegwer, Steve; Hubbard, Robert; McBride, William; Shimko, Steve; Wöger, Friedrich; Ditsler, Jennifer

    2012-09-01

    The National Solar Observatory’s (NSO) Advanced Technology Solar Telescope (ATST) is the first large U.S. solar telescope accessible to the worldwide solar physics community to be constructed in more than 30 years. The 4-meter diameter facility will operate over a broad wavelength range (0.35 to 28 μm ), employing adaptive optics systems to achieve diffraction limited imaging and resolve features approximately 20 km on the Sun; the key observational parameters (collecting area, spatial resolution, spectral coverage, polarization accuracy, low scattered light) enable resolution of the theoretically-predicted, fine-scale magnetic features and their dynamics which modulate the radiative output of the sun and drive the release of magnetic energy from the Sun’s atmosphere in the form of flares and coronal mass ejections. In 2010, the ATST received a significant fraction of its funding for construction. In the subsequent two years, the project has hired staff and opened an office on Maui. A number of large industrial contracts have been placed throughout the world to complete the detailed designs and begin constructing the major telescope subsystems. These contracts have included the site development, AandE designs, mirrors, polishing, optic support assemblies, telescope mount and coudé rotator structures, enclosure, thermal and mechanical systems, and high-level software and controls. In addition, design development work on the instrument suite has undergone significant progress; this has included the completion of preliminary design reviews (PDR) for all five facility instruments. Permitting required for physically starting construction on the mountaintop of Haleakalā, Maui has also progressed. This paper will review the ATST goals and specifications, describe each of the major subsystems under construction, and review the contracts and lessons learned during the contracting and early construction phases. Schedules for site construction, key factory testing of

  8. New advances in understanding the heterohelicid planktic foraminifer early evolution

    Directory of Open Access Journals (Sweden)

    Marius Dan Georgescu

    2013-12-01

    Full Text Available Three Late Cretaceous lineages of heterohelicid planktic foraminifera, which evolved in the proximity of the Cenomanian/Turonian boundary, bring new data in understanding the group evolutionary history. Lunatriella Eicher and Worstell 1970a is a directional lineage of late Cenomanian-early Turonian age, which gradually develops peripheral backward extensions in the last-formed chambers. Steineckia Georgescu 2009a of the Turonian is the earliest heterohelicid lineage that evolved ornamentation consisting of pore mounds; a gap spanning the latest Turonian-early Santonian separates it from Laeviheterohelix Nederbragt 1991 of the late Santonian-Campanian, the second lineage that developed ornamentation consisting of pore mounds. Pseudoplanoglobulina Aliyulla 1977 evolved in the early Turonian and is the first heterohelicid lineage that developed multichamber growth in the adult stage; it became extinct in the Santonian. The three directional lineages show that the iterative and convergent evolution patterns occur extensively in the early heterohelicid history.

  9. Morphological Priming Effects on Children's Spelling

    Science.gov (United States)

    Rosa, Joao Manuel; Nunes, Terezinha

    2008-01-01

    Previous research has suggested that children in the early grades of primary school do not have much awareness of morphemes. In this study, a priming paradigm was used to try to detect early signs of morphological representation of stems through a spelling task presented to Portuguese children (N = 805; age range 6-9 years). Primes shared the stem…

  10. Sequential decays of the. Upsilon. prime prime

    Energy Technology Data Exchange (ETDEWEB)

    Heintz, U.; Kaarsberg, T.; Lee-Franzini, J.; Lovelock, D.M.J.; Narain, M.; Schamberger, R.D.; Willins, J.; Yanagisawa, C. (Department of Physics, State University of New York at Stony Brook, Stony Brook, New York 11794 (USA)); Franzini, P.; Tuts, P.M.; Kanekal, S.; Wu, Q. (Columbia University, New York, New York 10027 (USA))

    1991-03-25

    We have studied the decay chain {Upsilon}{prime}{prime}{r arrow}{chi}{sub {ital b}}{sup {prime}}({chi}{sub {ital b}}){gamma} {r arrow}{Upsilon}{prime}({Upsilon}){gamma}{gamma}{r arrow}{mu}{mu}({ital ee}){gamma}{gamma} with the CUSB II detector at the Cornell Electron Storage Ring. For a sample of 1.33{times}10{sup 6} {Upsilon}{prime}{prime}'s we find {approx}400 events. We measure branching ratios for {chi}{sub {ital b}{ital J}}{sup {prime}}{r arrow}{Upsilon}{prime}({Upsilon}){gamma} and, using calculated {ital E}1 rates, we derive total and hadronic widths of the {chi}{sub {ital b}}{sup {prime}} states. From these widths we obtain values of {alpha}{sub {ital s}} in the range between 0.13 and 0.21, in agreement with other determinations. We observe the suppressed decay {Upsilon}{prime}{prime}{r arrow}{chi}{sub {ital b}}{gamma}. The measured branching ratio suggests that relativistic effects are important. We also determine the branching ratios for {Upsilon}{prime}{prime}{r arrow}{Upsilon}{prime}{pi}{sup 0}{pi}{sup 0} to be (1.3{plus minus}0.4{plus minus}0.2)% and {Upsilon}{prime}{prime}{r arrow}{Upsilon}{pi}{sup 0}{pi}{sup 0} to be (1.8{plus minus}0.3{plus minus}0.2)%.

  11. Ultrasonography and magnetic resonance imaging in early rheumatoid arthritis: recent advances

    DEFF Research Database (Denmark)

    Østergaard, Mikkel; Døhn, Uffe M; Ejbjerg, Bo J;

    2006-01-01

    Efficient methods for diagnosis, monitoring, and prognostication are essential in early rheumatoid arthritis. Data on the value of ultrasonography and MRI are accumulating rapidly, fueling their increasing use in early rheumatoid arthritis. This review focuses on recent advances in the clinical a...... applications of these imaging modalities. Udgivelsesdato: 2006-Oct...

  12. Photodynamic therapy for locally advanced pancreatic cancer: early clinical results

    Science.gov (United States)

    Sandanayake, N. S.; Huggett, M. T.; Bown, S. G.; Pogue, B. W.; Hasan, T.; Pereira, S. P.

    2010-02-01

    Pancreatic adenocarcinoma ranks as the fourth most common cause of cancer death in the USA. Patients usually present late with advanced disease, limiting attempted curative surgery to 10% of cases. Overall prognosis is poor with one-year survival rates of less than 10% with palliative chemotherapy and/or radiotherapy. Given these dismal results, a minimally invasive treatment capable of local destruction of tumor tissue with low morbidity may have a place in the treatment of this disease. In this paper we review the preclinical photodynamic therapy (PDT) studies which have shown that it is possible to achieve a zone of necrosis in normal pancreas and implanted tumour tissue. Side effects of treatment and evidence of a potential survival advantage are discussed. We describe the only published clinical study of pancreatic interstitial PDT, which was carried out by our group (Bown et al Gut 2002), in 16 patients with unresectable locally advanced pancreatic adenocarcinoma. All patients had evidence of tumor necrosis on follow-up imaging, with a median survival from diagnosis of 12.5 months. Finally, we outline a phase I dose-escalation study of verteporfin single fibre PDT followed by standard gemcitabine chemotherapy which our group is currently undertaking in patients with locally advanced pancreatic cancer. Randomized controlled studies are also planned.

  13. Priming of antiherbivore defensive responses in plants

    Institute of Scientific and Technical Information of China (English)

    Jinwon Kim; Gary W.Felton

    2013-01-01

    Defense priming is defined as increased readiness of defense induction.A growing body of literature indicates that plants (or intact parts of a plant) are primed in anticipation of impending environmental stresses,both biotic and abiotic,and upon the following stimulus,induce defenses more quickly and strongly.For instance,some plants previously exposed to herbivore-inducible plant volatiles (HIPVs) from neighboring plants under herbivore attack show faster or stronger defense activation and enhanced insect resistance when challenged with secondary insect feeding.Research on priming of antiherbivore defense has been limited to the HIPV-mediated mechanism until recently,but significant advances were made in the past three years,including non-HIPV-mediated defense priming,epigenetic modifications as the molecular mechanism of priming,and others.It is timely to consider the advances in research on defense priming in the plantinsect interactions.

  14. Prime Mover

    DEFF Research Database (Denmark)

    Wagner, Michael Frederik

    2002-01-01

    The important issue of technological determinism is analysed in relation to various theoretical positions, and it is highlighted with a chain of empirical cases drawn form history. The fundamental questions to be considered is the nature of determinism in Karl Marx' philosophical work and the shi...... of modernism versus primitivism in historiography. This question is narrowed down to the discussion of the vertical water wheel as the prime mover in history. The problem is related to the abuse of technical development as an independent variable in general history....

  15. Prime Mover

    DEFF Research Database (Denmark)

    Wagner, Michael Frederik

    2002-01-01

    The important issue of technological determinism is analysed in relation to various theoretical positions, and it is highlighted with a chain of empirical cases drawn form history. The fundamental questions to be considered is the nature of determinism in Karl Marx' philosophical work and the shi...... of modernism versus primitivism in historiography. This question is narrowed down to the discussion of the vertical water wheel as the prime mover in history. The problem is related to the abuse of technical development as an independent variable in general history....

  16. Early skin toxicity predicts better outcomes, and early tumor shrinkage predicts better response after cetuximab treatment in advanced colorectal cancer.

    Science.gov (United States)

    Kogawa, T; Doi, A; Shimokawa, M; Fouad, T M; Osuga, T; Tamura, F; Mizushima, T; Kimura, T; Abe, S; Ihara, H; Kukitsu, T; Sumiyoshi, T; Yoshizaki, N; Hirayama, M; Sasaki, T; Kawarada, Y; Kitashiro, S; Okushiba, S; Kondo, H; Tsuji, Y

    2015-03-01

    Cetuximab-containing treatments for metastatic colorectal cancer have been shown to have higher overall response rates and longer progression-free and overall survival than other systemic therapies. Cetuximab-related manifestations, including severe skin toxicity and early tumor shrinkage, have been shown to be predictors of response to cetuximab. We hypothesized that early skin toxicity is a predictor of response and better outcomes in patients with advanced colorectal carcinoma. We retrospectively evaluated 62 patients with colorectal adenocarcinoma who had unresectable tumors and were treated with cetuximab in our institution. Skin toxicity grade was evaluated on each treatment day. Tumor size was evaluated using computed tomography prior to treatment and 4-8 weeks after the start of treatment with cetuximab.Patients with early tumor shrinkage after starting treatment with cetuximab had a significantly higher overall response rate (P = 0.0001). Patients with early skin toxicity showed significantly longer overall survival (P = 0.0305), and patients with higher skin toxicity grades had longer progression-free survival (P = 0.0168).We have shown that early tumor shrinkage, early onset of skin toxicity, and high skin toxicity grade are predictors of treatment efficacy and/or outcome in patients with advanced colorectal carcinoma treated with cetuximab.

  17. The cheetah Acinonyx pardinensis (Croizet et Jobert, 1828) s.l. at the hominin site of Dmanisi (Georgia) - A potential prime meat supplier in Early Pleistocene ecosystems

    Science.gov (United States)

    Hemmer, Helmut; Kahlke, Ralf-Dietrich; Vekua, Abesalom K.

    2011-09-01

    The fossil site of Dmanisi (southern Georgia) has yielded a significant amount of hominin remains dated to around 1.8 Ma, in addition to a rich contemporaneous faunal record. Based on topographic information combined with an updated list of the vertebrate faunal assemblage, the corresponding palaeo-landscape has been reconstructed. Over a distance of some kilometres the landscape pattern changed from that of a forested valley floor, to tree savannah and open grasslands, thus providing typical habitats for carnivores hunting in open spaces. Morphological analysis of the elements from a nearly complete cat's foreleg reveals the existence of a large and stoutly built cheetah, Acinonyx pardinensis (Croizet et Jobert, 1828) s.l., in the Dmanisi faunal assemblage. Body mass estimations based on the humerus and metacarpals point to a cat of around 100 kg. The amount of pure meat and associated leftovers produced by the cheetah's hunting activity available for other consumers has been estimated. Within Early Pleistocene ecosystems, the cheetah must be considered as a potential fresh prime meat supplier, above that of any other felid.

  18. Effects of Early Acceleration of Students in Mathematics on Taking Advanced Mathematics Coursework in High School

    Science.gov (United States)

    Ma, Xin

    2010-01-01

    Based on data from the Longitudinal Study of American Youth (LSAY), students were classified into high-, middle-, and low-ability students. The effects of early acceleration in mathematics on the most advanced mathematics coursework (precalculus and calculus) in high school were examined in each category. Results showed that although early…

  19. Effects of Early Acceleration of Students in Mathematics on Taking Advanced Mathematics Coursework in High School

    Science.gov (United States)

    Ma, Xin

    2010-01-01

    Based on data from the Longitudinal Study of American Youth (LSAY), students were classified into high-, middle-, and low-ability students. The effects of early acceleration in mathematics on the most advanced mathematics coursework (precalculus and calculus) in high school were examined in each category. Results showed that although early…

  20. Masked immediate-repetition-priming effect on the early lexical process in the bilateral anterior temporal areas assessed by neuromagnetic responses.

    Science.gov (United States)

    Fujimaki, Norio; Hayakawa, Tomoe; Ihara, Aya; Matani, Ayumu; Wei, Qiang; Terazono, Yasushi; Murata, Tsutomu

    2010-10-01

    A masked priming paradigm has been used to measure unconscious and automatic context effects on the processing of words. However, its spatiotemporal neural basis has not yet been clarified. To test the hypothesis that masked repetition priming causes enhancement of neural activation, we conducted a magnetoencephalography experiment in which a prime was visually presented for a short duration (50 ms), preceded by a mask pattern, and followed by a target word that was represented by a Japanese katakana syllabogram. The prime, which was identical to the target, was represented by another hiragana syllabogram in the "Repeated" condition, whereas it was a string of unreadable pseudocharacters in the "Unrepeated" condition. Subjects executed a categorical decision task on the target. Activation was significantly larger for the Repeated condition than for the Unrepeated condition at a time window of 150-250 ms in the right occipital area, 200-250 ms in the bilateral ventral occipitotemporal areas, and 200-250 ms and 200-300 ms in the left and right anterior temporal areas, respectively. These areas have been reported to be related to processing of visual-form/orthography and lexico-semantics, and the enhanced activation supports the hypothesis. However, the absence of the priming effect in the areas related to phonological processing implies that automatic phonological priming effect depends on task requirements. 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

  1. Global strategies for the treatment of early-stage and advanced cervical cancer.

    Science.gov (United States)

    Dueñas-González, Alfonso; Campbell, Sergio

    2016-02-01

    Recent peer-reviewed publications on the treatment of early, locally advanced and advanced cervical cancer patients are reviewed to gain insight into the main research done in the field. In early-stage patients where cure is offered to most patients, research focuses on more conservative or less morbid approaches to increase quality of life and reduce the treatment-related sexual dysfunction. No major advances have occurred for treating locally advanced disease since the introduction of concurrent chemoradiation, but efforts are directed to increase efficacy while reducing toxicity with the use of combination chemoradiation and modern radiation technologies. Molecular-targeted therapy and identification of targetable gene alterations as well as immunotherapy are actively pursued in patients with advanced disease. Although global statistics indicate a trend for decreased age-standardized incidence rates, social and economical factors impede the uptake of therapeutic advances achieved as many patients have no access even to basic resources for treating cancer. The adherence to quality indicators in delivery of optimized standard concurrent chemoradiation and adherence to guidelines in cervical cancer surgery must not be underestimated. Major efforts are needed in both the scientific and social aspects of cervical cancer treatment to reduce mortality.

  2. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis.

    Science.gov (United States)

    Björkegren, Johan L M; Hägg, Sara; Talukdar, Husain A; Foroughi Asl, Hassan; Jain, Rajeev K; Cedergren, Cecilia; Shang, Ming-Mei; Rossignoli, Aránzazu; Takolander, Rabbe; Melander, Olle; Hamsten, Anders; Michoel, Tom; Skogsberg, Josefin

    2014-02-01

    Plasma cholesterol lowering (PCL) slows and sometimes prevents progression of atherosclerosis and may even lead to regression. Little is known about how molecular processes in the atherosclerotic arterial wall respond to PCL and modify responses to atherosclerosis regression. We studied atherosclerosis regression and global gene expression responses to PCL (≥80%) and to atherosclerosis regression itself in early, mature, and advanced lesions. In atherosclerotic aortic wall from Ldlr(-/-)Apob (100/100) Mttp (flox/flox)Mx1-Cre mice, atherosclerosis regressed after PCL regardless of lesion stage. However, near-complete regression was observed only in mice with early lesions; mice with mature and advanced lesions were left with regression-resistant, relatively unstable plaque remnants. Atherosclerosis genes responding to PCL before regression, unlike those responding to the regression itself, were enriched in inherited risk for coronary artery disease and myocardial infarction, indicating causality. Inference of transcription factor (TF) regulatory networks of these PCL-responsive gene sets revealed largely different networks in early, mature, and advanced lesions. In early lesions, PPARG was identified as a specific master regulator of the PCL-responsive atherosclerosis TF-regulatory network, whereas in mature and advanced lesions, the specific master regulators were MLL5 and SRSF10/XRN2, respectively. In a THP-1 foam cell model of atherosclerosis regression, siRNA targeting of these master regulators activated the time-point-specific TF-regulatory networks and altered the accumulation of cholesterol esters. We conclude that PCL leads to complete atherosclerosis regression only in mice with early lesions. Identified master regulators and related PCL-responsive TF-regulatory networks will be interesting targets to enhance PCL-mediated regression of mature and advanced atherosclerotic lesions.

  3. Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis

    Science.gov (United States)

    Björkegren, Johan L. M.; Hägg, Sara; Jain, Rajeev K.; Cedergren, Cecilia; Shang, Ming-Mei; Rossignoli, Aránzazu; Takolander, Rabbe; Melander, Olle; Hamsten, Anders; Michoel, Tom; Skogsberg, Josefin

    2014-01-01

    Plasma cholesterol lowering (PCL) slows and sometimes prevents progression of atherosclerosis and may even lead to regression. Little is known about how molecular processes in the atherosclerotic arterial wall respond to PCL and modify responses to atherosclerosis regression. We studied atherosclerosis regression and global gene expression responses to PCL (≥80%) and to atherosclerosis regression itself in early, mature, and advanced lesions. In atherosclerotic aortic wall from Ldlr−/−Apob 100/100 Mttp flox/floxMx1-Cre mice, atherosclerosis regressed after PCL regardless of lesion stage. However, near-complete regression was observed only in mice with early lesions; mice with mature and advanced lesions were left with regression-resistant, relatively unstable plaque remnants. Atherosclerosis genes responding to PCL before regression, unlike those responding to the regression itself, were enriched in inherited risk for coronary artery disease and myocardial infarction, indicating causality. Inference of transcription factor (TF) regulatory networks of these PCL-responsive gene sets revealed largely different networks in early, mature, and advanced lesions. In early lesions, PPARG was identified as a specific master regulator of the PCL-responsive atherosclerosis TF-regulatory network, whereas in mature and advanced lesions, the specific master regulators were MLL5 and SRSF10/XRN2, respectively. In a THP-1 foam cell model of atherosclerosis regression, siRNA targeting of these master regulators activated the time-point-specific TF-regulatory networks and altered the accumulation of cholesterol esters. We conclude that PCL leads to complete atherosclerosis regression only in mice with early lesions. Identified master regulators and related PCL-responsive TF-regulatory networks will be interesting targets to enhance PCL-mediated regression of mature and advanced atherosclerotic lesions. PMID:24586211

  4. Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis.

    Directory of Open Access Journals (Sweden)

    Johan L M Björkegren

    2014-02-01

    Full Text Available Plasma cholesterol lowering (PCL slows and sometimes prevents progression of atherosclerosis and may even lead to regression. Little is known about how molecular processes in the atherosclerotic arterial wall respond to PCL and modify responses to atherosclerosis regression. We studied atherosclerosis regression and global gene expression responses to PCL (≥80% and to atherosclerosis regression itself in early, mature, and advanced lesions. In atherosclerotic aortic wall from Ldlr(-/-Apob (100/100 Mttp (flox/floxMx1-Cre mice, atherosclerosis regressed after PCL regardless of lesion stage. However, near-complete regression was observed only in mice with early lesions; mice with mature and advanced lesions were left with regression-resistant, relatively unstable plaque remnants. Atherosclerosis genes responding to PCL before regression, unlike those responding to the regression itself, were enriched in inherited risk for coronary artery disease and myocardial infarction, indicating causality. Inference of transcription factor (TF regulatory networks of these PCL-responsive gene sets revealed largely different networks in early, mature, and advanced lesions. In early lesions, PPARG was identified as a specific master regulator of the PCL-responsive atherosclerosis TF-regulatory network, whereas in mature and advanced lesions, the specific master regulators were MLL5 and SRSF10/XRN2, respectively. In a THP-1 foam cell model of atherosclerosis regression, siRNA targeting of these master regulators activated the time-point-specific TF-regulatory networks and altered the accumulation of cholesterol esters. We conclude that PCL leads to complete atherosclerosis regression only in mice with early lesions. Identified master regulators and related PCL-responsive TF-regulatory networks will be interesting targets to enhance PCL-mediated regression of mature and advanced atherosclerotic lesions.

  5. Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment.

    Science.gov (United States)

    Novak, Iona; Morgan, Cathy; Adde, Lars; Blackman, James; Boyd, Roslyn N; Brunstrom-Hernandez, Janice; Cioni, Giovanni; Damiano, Diane; Darrah, Johanna; Eliasson, Ann-Christin; de Vries, Linda S; Einspieler, Christa; Fahey, Michael; Fehlings, Darcy; Ferriero, Donna M; Fetters, Linda; Fiori, Simona; Forssberg, Hans; Gordon, Andrew M; Greaves, Susan; Guzzetta, Andrea; Hadders-Algra, Mijna; Harbourne, Regina; Kakooza-Mwesige, Angelina; Karlsson, Petra; Krumlinde-Sundholm, Lena; Latal, Beatrice; Loughran-Fowlds, Alison; Maitre, Nathalie; McIntyre, Sarah; Noritz, Garey; Pennington, Lindsay; Romeo, Domenico M; Shepherd, Roberta; Spittle, Alicia J; Thornton, Marelle; Valentine, Jane; Walker, Karen; White, Robert; Badawi, Nadia

    2017-09-01

    Cerebral palsy describes the most common physical disability in childhood and occurs in 1 in 500 live births. Historically, the diagnosis has been made between age 12 and 24 months but now can be made before 6 months' corrected age. To systematically review best available evidence for early, accurate diagnosis of cerebral palsy and to summarize best available evidence about cerebral palsy-specific early intervention that should follow early diagnosis to optimize neuroplasticity and function. This study systematically searched the literature about early diagnosis of cerebral palsy in MEDLINE (1956-2016), EMBASE (1980-2016), CINAHL (1983-2016), and the Cochrane Library (1988-2016) and by hand searching. Search terms included cerebral palsy, diagnosis, detection, prediction, identification, predictive validity, accuracy, sensitivity, and specificity. The study included systematic reviews with or without meta-analyses, criteria of diagnostic accuracy, and evidence-based clinical guidelines. Findings are reported according to the PRISMA statement, and recommendations are reported according to the Appraisal of Guidelines, Research and Evaluation (AGREE) II instrument. Six systematic reviews and 2 evidence-based clinical guidelines met inclusion criteria. All included articles had high methodological Quality Assessment of Diagnostic Accuracy Studies (QUADAS) ratings. In infants, clinical signs and symptoms of cerebral palsy emerge and evolve before age 2 years; therefore, a combination of standardized tools should be used to predict risk in conjunction with clinical history. Before 5 months' corrected age, the most predictive tools for detecting risk are term-age magnetic resonance imaging (86%-89% sensitivity), the Prechtl Qualitative Assessment of General Movements (98% sensitivity), and the Hammersmith Infant Neurological Examination (90% sensitivity). After 5 months' corrected age, the most predictive tools for detecting risk are magnetic resonance imaging (86

  6. ON ALMOST PRIME SUBMODULES

    Institute of Scientific and Technical Information of China (English)

    Hani A. Khashan

    2012-01-01

    In this article,we define almost prime submodules as a new generalization of prime and weakly prime submodules of unitary modules over a commutative ring with identity.We study some basic properties of almost prime submodules and give some characterizations of them,especially for (finitely generated faithful) multiplication modules.

  7. Investigation of a Modern Incipient Stromatolite from Obsidian Pool Prime, Yellowstone National Park: Implications for Early Lithification in the Formation of Light-Dark Stromatolite Laminae

    Science.gov (United States)

    Corsetti, F. A.; Berelson, W.; Pepe-Ranney, C. P.; Mata, S. A.; Spear, J. R.

    2016-12-01

    Stromatolites have been defined multiple ways, but the presence of lamination is common to all definitions. Despite this commonality, the origin of the lamination in many ancient stromatolites remains vague. Lamination styles vary, but sub-mm light-dark couplets are common in many ancient stromatolites. Here, we investigate an actively forming incipient stromatolite from Obsidian Pool Prime (OPP), a hot spring in Yellowstone National Park, to better understand the formation of light-dark couplets similar to many ancient stromatolites in texture and structure. In the OPP stromatolites, a dense network of layer-parallel bundles of cyanobacterial filaments (a dark layer) is followed by an open network of layer-perpendicular or random filaments (a light layer) that reflect a diurnal cycle in the leading edge of the microbial mat that coats the stromatolite's surface. Silica crust encases the cyanobacterial filaments maintaining the integrity of the lamination. Bubbles formed via oxygenic photosynthesis are commonly trapped within the light layers, indicating that lithification occurs rapidly before the bubbles can collapse. The filamentous, non-heterocystous stromatoite-building cyanobacterium from OPP is most closely related to a stromatolite-building cyanobacterium from a hot spring in Japan. Once built, "tenants" from multiple microbial phyla move into the structure, mixing and mingling to produce a complicated integrated biogeochemical signal that may be difficult to untangle in ancient examples. While the cyanobacterial response to the diurnal cycle has been previously implicated in the formation of light-dark couplets, the OPP example highlights the importance of early lithification in maintaining the fabric. Thus, the presence of light-dark couplets and bubble structures may indicate very early lithification and therefore a certain degree of mineral saturation in the ancient ocean or other aquatic system, and that bubble structures, if present, may be evidence

  8. Motor Priming in Neurorehabilitation

    OpenAIRE

    Stoykov, Mary Ellen; Madhavan, Sangeetha

    2015-01-01

    Priming is a type of implicit learning wherein a stimulus prompts a change in behavior. Priming has been long studied in the field of psychology. More recently, rehabilitation researchers have studied motor priming as a possible way to facilitate motor learning. For example, priming of the motor cortex is associated with changes in neuroplasticity that are associated with improvements in motor performance. Of the numerous motor priming paradigms under investigation, only a few ...

  9. Motor Priming in Neurorehabilitation

    OpenAIRE

    Stoykov, Mary Ellen; Madhavan, Sangeetha

    2015-01-01

    Priming is a type of implicit learning wherein a stimulus prompts a change in behavior. Priming has been long studied in the field of psychology. More recently, rehabilitation researchers have studied motor priming as a possible way to facilitate motor learning. For example, priming of the motor cortex is associated with changes in neuroplasticity that are associated with improvements in motor performance. Of the numerous motor priming paradigms under investigation, only a few ...

  10. The temporal dynamics of visual object priming.

    Science.gov (United States)

    Ko, Philip C; Duda, Bryant; Hussey, Erin P; Mason, Emily J; Ally, Brandon A

    2014-11-01

    Priming reflects an important means of learning that is mediated by implicit memory. Importantly, priming occurs for previously viewed objects (item-specific priming) and their category relatives (category-wide priming). Two distinct neural mechanisms are known to mediate priming, including the sharpening of a neural object representation and the retrieval of stimulus-response mappings. Here, we investigated whether the relationship between these neural mechanisms could help explain why item-specific priming generates faster responses than category-wide priming. Participants studied pictures of everyday objects, and then performed a difficult picture identification task while we recorded event-related potentials (ERP). The identification task gradually revealed random line segments of previously viewed items (Studied), category exemplars of previously viewed items (Exemplar), and items that were not previously viewed (Unstudied). Studied items were identified sooner than Unstudied items, showing evidence of item-specific priming, and importantly Exemplar items were also identified sooner than Unstudied items, showing evidence of category-wide priming. Early activity showed sustained neural suppression of parietal activity for both types of priming. However, these neural suppression effects may have stemmed from distinct processes because while category-wide neural suppression was correlated with priming behavior, item-specific neural suppression was not. Late activity, examined with response-locked ERPs, showed additional processes related to item-specific priming including neural suppression in occipital areas and parietal activity that was correlated with behavior. Together, we conclude that item-specific and category-wide priming are mediated by separate, parallel neural mechanisms in the context of the current paradigm. Temporal differences in behavior are determined by the timecourses of these distinct processes.

  11. Reversing Early Retirement in Advanced Welfare Economies A Paradigm Shift to Overcome Push and Pull Factors

    Directory of Open Access Journals (Sweden)

    Dr. Bernhard Ebbinghaus

    2013-12-01

    Full Text Available Recent reform efforts of advanced welfare states have attempted to reverse trends in early retirement and increase the statutory retirement age. This paradigm shift often occurred against the protest of unions, fi rms and their employees. As a consequence of expanding welfare states and as response to economic challenges since the 1970s early exit from work has become a widespread practice. Early retirement has been part of Continental Europe’s welfare without work problem, while the Scandinavian welfare states, the Anglophone liberal economies and the Japanese welfare society were able to maintain higher levels of employment for older workers. Since the 1990s, an international consensus to reverse early exit from work emerged among international organisations and national policy experts. Based on a comparative historical analysis of selected OECD countries, this study analyses the cross-national variations in the institutionalisation of early exit regimes and its recent reversal using macro-indictors on early exit trends and stylised information on institutional arrangements. Comparing the interaction of social policy and economic institutions, it reviews the cross-national differences in welfare state “pull” and economic “push” factors that have contributed to early exit from work and discusses the likely impact of welfare retrenchment and assesses the importance of “retention” factors such as activation policies for decreasing early exit from work.

  12. An early and enduring advanced technology originating 71,000 years ago in South Africa.

    Science.gov (United States)

    Brown, Kyle S; Marean, Curtis W; Jacobs, Zenobia; Schoville, Benjamin J; Oestmo, Simen; Fisher, Erich C; Bernatchez, Jocelyn; Karkanas, Panagiotis; Matthews, Thalassa

    2012-11-22

    There is consensus that the modern human lineage appeared in Africa before 100,000 years ago. But there is debate as to when cultural and cognitive characteristics typical of modern humans first appeared, and the role that these had in the expansion of modern humans out of Africa. Scientists rely on symbolically specific proxies, such as artistic expression, to document the origins of complex cognition. Advanced technologies with elaborate chains of production are also proxies, as these often demand high-fidelity transmission and thus language. Some argue that advanced technologies in Africa appear and disappear and thus do not indicate complex cognition exclusive to early modern humans in Africa. The origins of composite tools and advanced projectile weapons figure prominently in modern human evolution research, and the latter have been argued to have been in the exclusive possession of modern humans. Here we describe a previously unrecognized advanced stone tool technology from Pinnacle Point Site 5-6 on the south coast of South Africa, originating approximately 71,000 years ago. This technology is dominated by the production of small bladelets (microliths) primarily from heat-treated stone. There is agreement that microlithic technology was used to create composite tool components as part of advanced projectile weapons. Microliths were common worldwide by the mid-Holocene epoch, but have a patchy pattern of first appearance that is rarely earlier than 40,000 years ago, and were thought to appear briefly between 65,000 and 60,000 years ago in South Africa and then disappear. Our research extends this record to ~71,000 years, shows that microlithic technology originated early in South Africa, evolved over a vast time span (~11,000 years), and was typically coupled to complex heat treatment that persisted for nearly 100,000 years. Advanced technologies in Africa were early and enduring; a small sample of excavated sites in Africa is the best explanation for any

  13. Efficient Prime Counting and the Chebyshev Primes

    Directory of Open Access Journals (Sweden)

    Michel Planat

    2013-01-01

    Full Text Available The function where is the logarithm integral and the number of primes up to is well known to be positive up to the (very large Skewes' number. Likewise, according to Robin's work, the functions and , where and are Chebyshev summatory functions, are positive if and only if Riemann hypothesis (RH holds. One introduces the jump function at primes and one investigates , , and . In particular, , and for . Besides, for any odd , an infinite set of the so-called Chebyshev primes. In the context of RH, we introduce the so-called Riemann primes as champions of the function (or of the function . Finally, we find a good prime counting function , that is found to be much better than the standard Riemann prime counting function.

  14. Task-Dependent Masked Priming Effects in Visual Word Recognition

    OpenAIRE

    Sachiko eKinoshita; Dennis eNorris

    2012-01-01

    A method used widely to study the first 250 ms of visual word recognition is masked priming: These studies have yielded a rich set of data concerning the processes involved in recognizing letters and words. In these studies, there is an implicit assumption that the early processes in word recognition tapped by masked priming are automatic, and masked priming effects should therefore be invariant across tasks. Contrary to this assumption, masked priming effects are modulated by the task goal...

  15. Prime mover progress

    Energy Technology Data Exchange (ETDEWEB)

    Hennagir, T.

    1995-05-01

    Manufacturers continue to upgrade fluidized bed and steam technologies to meet more stringent emission, efficiency and service challenges from global power market customers. Offshore, suppliers are being pushed to provide quality, low-cost production and significant local competitive presence in nearly all international markets. The ability to meet customer and regulatory demands for emissions across different global market segments remains a priority for prime mover suppliers as they develop environmental technical improvements. Products initially developed for the more stringent European regulations are now finding a market in the US. In developing countries, demand continues for utility-size boiler products, but pollution control equipment costs remain a parallel consideration. Industry improvements to steam cycle equipment, namely turbines, continue to reap benefits in terms of efficiency and operational flexibility. Boiler and steam manufacturers` response to global markets remains right on target as product development strategies are constantly adjusted and analyzed to reach an optimum marketing mix. Innovation and advances in prime mover power equipment technology remain a mainstay of suppliers` ability to meet the needs of a changing, competitive clientele.

  16. The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors.

    Science.gov (United States)

    Mille, Frédéric; Tamayo-Orrego, Lukas; Lévesque, Martin; Remke, Marc; Korshunov, Andrey; Cardin, Julie; Bouchard, Nicolas; Izzi, Luisa; Kool, Marcel; Northcott, Paul A; Taylor, Michael D; Pfister, Stefan M; Charron, Frédéric

    2014-10-13

    During cerebellar development, Sonic hedgehog (Shh) signaling drives the proliferation of granule cell precursors (GCPs). Aberrant activation of Shh signaling causes overproliferation of GCPs, leading to medulloblastoma. Although the Shh-binding protein Boc associates with the Shh receptor Ptch1 to mediate Shh signaling, whether Boc plays a role in medulloblastoma is unknown. Here, we show that BOC is upregulated in medulloblastomas and induces GCP proliferation. Conversely, Boc inactivation reduces proliferation and progression of early medulloblastomas to advanced tumors. Mechanistically, we find that Boc, through elevated Shh signaling, promotes high levels of DNA damage, an effect mediated by CyclinD1. High DNA damage in the presence of Boc increases the incidence of Ptch1 loss of heterozygosity, an important event in the progression from early to advanced medulloblastoma. Together, our results indicate that DNA damage promoted by Boc leads to the demise of its own coreceptor, Ptch1, and consequently medulloblastoma progression.

  17. Orofacial hereditary haemorrhagic telangiectasia: high power diode laser in early and advanced lesion treatment

    Science.gov (United States)

    Tempesta, Angela; Franco, Simonetta; Miccoli, Simona; Suppressa, Patrizia; De Falco, Vincenzo; Crincoli, Vito; Lacaita, Mariagrazia; Giuliani, Michele; Favia, Gianfranco

    2014-01-01

    Hereditary Haemorrhagic Telangiectasia (HHT) is a muco-cutaneous inherited disease. Symptoms are epistaxis, visceral arterio-venous malformations, multiple muco-cutaneous telangiectasia with the risk of number increasing enlargement, bleeding, and super-infection. The aim of this work is to show the dual Diode Laser efficacy in preventive treatment of Early Lesions (EL < 2mm) and therapeutic treatment of Advanced Lesions (AL < 2mm). 21 patients affected by HHT with 822 muco-cutaneous telangiectatic nodules have been treated in several sessions with local anaesthesia and cooling of treated sites. EL preventive treatment consists of single Laser impulse (fibre 320) in ultrapulsed mode (2 mm single point spot). AL therapeutic treatment consists of repeated Laser impulses in pulsed mode (on 200ms / off 400ms). According to the results, Diode Laser used in pulsed and ultra-pulsed mode is very effective as noninvasive treatment both in early and advanced oral and perioral telangiectasia.

  18. Neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer: early outcome and technical impact on toxicity

    OpenAIRE

    Wang, Chia-Chun; Liang, Jin-Tung; Tsai, Chiao-Ling; Chen, Yu-Hsuan; Lin, Yu-Lin; Shun, Chia-Tung; Cheng, Jason Chia-Hsien

    2014-01-01

    Background We aimed to evaluate early clinical and pathological results for treating locally advanced rectal cancer with bevacizumab and neoadjuvant concurrent chemoradiotherapy using the technique of prone-position volumetric modulated arc therapy and to compare the toxicity of volumetric modulated arc therapy with that of supine-position four-field box radiotherapy. Methods Twelve patients with stage IIA to IVA rectal adenocarcinoma, treated with neoadjuvant concurrent chemoradiotherapy (45...

  19. Early Advanced LIGO binary neutron-star sky localization and parameter estimation

    CERN Document Server

    Berry, C P L; Farr, W M; Haster, C-J; Mandel, I; Middleton, H; Singer, L P; Urban, A L; Vecchio, A; Vitale, S; Cannon, K; Graff, P B; Hanna, C; Mohapatra, S; Pankow, C; Price, L R; Sidery, T; Veitch, J

    2016-01-01

    2015 will see the first observations of Advanced LIGO and the start of the gravitational-wave (GW) advanced-detector era. One of the most promising sources for ground-based GW detectors are binary neutron-star (BNS) coalescences. In order to use any detections for astrophysics, we must understand the capabilities of our parameter-estimation analysis. By simulating the GWs from an astrophysically motivated population of BNSs, we examine the accuracy of parameter inferences in the early advanced-detector era. We find that sky location, which is important for electromagnetic follow-up, can be determined rapidly (~5 s), but that sky areas may be hundreds of square degrees. The degeneracy between component mass and spin means there is significant uncertainty for measurements of the individual masses and spins; however, the chirp mass is well measured (typically better than 0.1%).

  20. Sequential experiments with primes

    CERN Document Server

    Caragiu, Mihai

    2017-01-01

    With a specific focus on the mathematical life in small undergraduate colleges, this book presents a variety of elementary number theory insights involving sequences largely built from prime numbers and contingent number-theoretic functions. Chapters include new mathematical ideas and open problems, some of which are proved in the text. Vector valued MGPF sequences, extensions of Conway’s Subprime Fibonacci sequences, and linear complexity of bit streams derived from GPF sequences are among the topics covered in this book. This book is perfect for the pure-mathematics-minded educator in a small undergraduate college as well as graduate students and advanced undergraduate students looking for a significant high-impact learning experience in mathematics.

  1. Priming analogical reasoning with false memories.

    Science.gov (United States)

    Howe, Mark L; Garner, Sarah R; Threadgold, Emma; Ball, Linden J

    2015-08-01

    Like true memories, false memories are capable of priming answers to insight-based problems. Recent research has attempted to extend this paradigm to more advanced problem-solving tasks, including those involving verbal analogical reasoning. However, these experiments are constrained inasmuch as problem solutions could be generated via spreading activation mechanisms (much like false memories themselves) rather than using complex reasoning processes. In three experiments we examined false memory priming of complex analogical reasoning tasks in the absence of simple semantic associations. In Experiment 1, we demonstrated the robustness of false memory priming in analogical reasoning when backward associative strength among the problem terms was eliminated. In Experiments 2a and 2b, we extended these findings by demonstrating priming on newly created homonym analogies that can only be solved by inhibiting semantic associations within the analogy. Overall, the findings of the present experiments provide evidence that the efficacy of false memory priming extends to complex analogical reasoning problems.

  2. Plasma matrix metalloproteinase 9 as an early surrogate biomarker of advanced colorectal neoplasia.

    Science.gov (United States)

    Gimeno-García, Antonio Z; Triñanes, Javier; Quintero, Enrique; Salido, Eduardo; Nicolás-Pérez, David; Adrián-de-Ganzo, Zaida; Alarcón-Fernández, Onofre; Abrante, Beatriz; Romero, Rafael; Carrillo, Marta; Ramos, Laura; Alonso, Inmaculada; Ortega, Juan; Jiménez, Alejandro

    2016-01-01

    Matrix metalloproteinases (MMPs) are overexpressed at different stages of colorectal carcinogenesis and could serve as early surrogate biomarkers of colorectal neoplasia. To assess the utility of plasma MMP2 and MMP9 levels in the detection of advanced colorectal neoplasia and their correlation with tissue levels. We analysed blood and tissue samples from patients with non-advanced adenomas (n=25), advanced adenomas (n=25), colorectal cancer (n=25) and healthy controls (n=75). Plasma and tissue gelatinase levels were determined by Luminex XMAP technology and gelatin zymography. Receiver operating characteristic (ROC) curve analysis was used to calculate the optimum cut-off for the detection of advanced colorectal neoplasia. Plasma MMP2 levels were similar between groups whatever the type of lesion. Plasma MMP9 levels were significantly higher in patients with neoplastic lesions than in healthy controls (median 292.3ng/ml vs. 139.08ng/ml, P<0.001). MMP9 levels were also higher in colorectal cancer than in non-advanced adenomas (median 314.6ng/ml vs. 274.3ng/ml, P=0.03). There was a significant correlation between plasma and tissue levels of MMP9 (r=0.5, P<0.001). The plasma MMP9 cut-off range with the highest diagnostic accuracy was between 173ng/ml and 204ng/ml (AUC=0.80 [95% CI: 0.72-0.86], P<0.001; sensitivity, 80-86% and specificity, 57-67%). Plasma MMP9 could be a surrogate biomarker for the early detection of advanced colorectal neoplasia, although its diagnostic performance could be increased by combination with other biomarkers. Copyright © 2015 Elsevier España, S.L.U. y AEEH y AEG. All rights reserved.

  3. Lung Cancer Workshop XI: Tobacco-Induced Disease: Advances in Policy, Early Detection and Management.

    Science.gov (United States)

    Mulshine, James L; Avila, Rick; Yankelevitz, David; Baer, Thomas M; Estépar, Raul San Jose; Ambrose, Laurie Fenton; Aldigé, Carolyn R

    2015-05-01

    The Prevent Cancer Foundation Lung Cancer Workshop XI: Tobacco-Induced Disease: Advances in Policy, Early Detection and Management was held in New York, NY on May 16 and 17, 2014. The two goals of the Workshop were to define strategies to drive innovation in precompetitive quantitative research on the use of imaging to assess new therapies for management of early lung cancer and to discuss a process to implement a national program to provide high quality computed tomography imaging for lung cancer and other tobacco-induced disease. With the central importance of computed tomography imaging for both early detection and volumetric lung cancer assessment, strategic issues around the development of imaging and ensuring its quality are critical to ensure continued progress against this most lethal cancer.

  4. Almost Graded Prime Ideals

    Directory of Open Access Journals (Sweden)

    Ameer Jaber

    2008-01-01

    Full Text Available Problem Statement: Graded commutative ring with unity over an abelian group were introduced by many authors such as T. Y. Lam and C. T. C. Wall, and almost prime ideals over commutative rings with unity were introduced by S.M. Batwadeker and P.K. Sharma, and this forced us to try to extend the theory of almost and n-almost prime ideals to the graded case. Approach: We develop the theory of almost and n-almost prime ideals to the graded case. Results: We extended some basic results about almost and n-almost prime ideals to the graded case, and then we gave a relationship between n-almost graded prime ideals and weakly graded prime ideals. Conclusion: The extended results about almost and n-almost graded prime ideals allow us to classify further properties about almost graded prime ideals. 2000 AMS Mathematics Subject Classification: 13 A 02.

  5. Task-Dependent Masked Priming Effects in Visual Word Recognition

    Science.gov (United States)

    Kinoshita, Sachiko; Norris, Dennis

    2012-01-01

    A method used widely to study the first 250 ms of visual word recognition is masked priming: These studies have yielded a rich set of data concerning the processes involved in recognizing letters and words. In these studies, there is an implicit assumption that the early processes in word recognition tapped by masked priming are automatic, and masked priming effects should therefore be invariant across tasks. Contrary to this assumption, masked priming effects are modulated by the task goal: For example, only word targets show priming in the lexical decision task, but both words and non-words do in the same-different task; semantic priming effects are generally weak in the lexical decision task but are robust in the semantic categorization task. We explain how such task dependence arises within the Bayesian Reader account of masked priming (Norris and Kinoshita, 2008), and how the task dissociations can be used to understand the early processes in lexical access. PMID:22675316

  6. Task-dependent masked priming effects in visual word recognition.

    Science.gov (United States)

    Kinoshita, Sachiko; Norris, Dennis

    2012-01-01

    A method used widely to study the first 250 ms of visual word recognition is masked priming: These studies have yielded a rich set of data concerning the processes involved in recognizing letters and words. In these studies, there is an implicit assumption that the early processes in word recognition tapped by masked priming are automatic, and masked priming effects should therefore be invariant across tasks. Contrary to this assumption, masked priming effects are modulated by the task goal: For example, only word targets show priming in the lexical decision task, but both words and non-words do in the same-different task; semantic priming effects are generally weak in the lexical decision task but are robust in the semantic categorization task. We explain how such task dependence arises within the Bayesian Reader account of masked priming (Norris and Kinoshita, 2008), and how the task dissociations can be used to understand the early processes in lexical access.

  7. Potential of advanced photoplethysmography sensing for noninvasive vascular diagnostics and early screening

    Science.gov (United States)

    Spigulis, Janis; Kukulis, Indulis; Fridenberga, Eva; Venckus, Girts

    2002-06-01

    Advanced sensor device for shape analysis of the tissue- reflected mean single period photoplethysmography (SPPPG) signals has been designed and clinically tested. The SPPPG signal shape reveals individual features of the patient's cardio-vascular state. Clinical studies of several patient groups (e.g. diabetes mellitus, atherosclerosis obliterans, Raynaud's syndrome) made possible to specify components of the SPPPG signal that are sensitive to the corresponding organic or functional pathologies. Comparison of the right and left arm finger SPPPG signal shapes, for instance, appears to be efficient tool for early screening of unilateral atherosclerosis obliterans.

  8. Linolenic acid prevents early and advanced glycation end-products (AGEs) modification of albumin.

    Science.gov (United States)

    Prasanna, Govindarajan; Saraswathi, N T

    2017-02-01

    In this study, we report the protective effects of linolenic acid towards the formation of early (HbA1c) and advanced glycation end-products (AGEs) based on fluorescence, circular dichroism, confocal microscopy and molecular interaction studies. Linolenic acid was found to be a potent inhibitor of AGEs formed by both glucose and fructose. The HbA1c (early glycation product) level was found to be reduced to 7.4% when compared to glycated control (8.4%). Similarly, linolenic acid also inhibited the methylglyoxal mediated AGEs formation. Circular dichroism spectroscopy studies suggested that the protective effect of linolenic acid for the helical structure of albumin. The molecular interaction studies showed that linolenic acid interacts with arginine residues of albumin with high affinity. Results suggested linolenic acid to be a potent antiglycation compound and also it could be a better lead compound for AGE inhibition.

  9. [Advancement in the research of early detection of bacterial nucleic acid in molecular diagnosis of sepsis].

    Science.gov (United States)

    Liu, Xiao; Ren, Hui; Peng, Dai-zhi

    2013-04-01

    Early diagnosis of sepsis helps make effective clinical decisions and improve the survival rate of patients with severe infection. However, the timely and accurate diagnosis of sepsis is still a great challenge in clinic. In order to settle the very problem, the scientists in the world have made a lot of exploration and research in the field of rapid molecular identification of pathogens. Nowadays, the nucleic acid detection of sepsis is mainly composed of 3 types of methodological strategies, either based on positive blood culture, single colonies, or directly on blood specimens. This paper presents a comprehensive overview of advances in the research of early detection of bacterial nucleic acid as molecular diagnosis of sepsis.

  10. Priming of plant resistance by natural compounds. Hexanoic acid as a model

    Directory of Open Access Journals (Sweden)

    Paz eAranega Bou

    2014-10-01

    Full Text Available Some alternative control strategies of currently emerging plant diseases are based on the use of resistance inducers. This review highlights the recent advances made in the characterization of natural compounds that induce resistance by a priming mechanism. These include vitamins, chitosans, oligogalacturonides, volatile organic compounds, azelaic and pipecolic acid, among others. Overall, other than providing novel disease control strategies that meet environmental regulations, natural priming agents are valuable tools to help unravel the complex mechanisms underlying the induced resistance phenomenon. The data presented in this review reflect the novel contributions made from studying these natural plant inducers, with special emphasis placed on hexanoic acid (Hx, proposed herein as a model tool for this research field. Hx is a potent natural priming agent of proven efficiency in a wide range of host plants and pathogens. It can early activate broad-spectrum defenses by inducing callose deposition and the SA and JA pathways. Later it can prime pathogen-specific responses according to the pathogen’s lifestyle. Interestingly, Hx primes redox-related genes to produce an anti-oxidant protective effect, which might be critical for limiting the infection of necrotrophs. Our Hx-induced resistance (Hx-IR findings also strongly suggest that it is an attractive tool for the molecular characterization of the plant alarmed state, with the added advantage of it being a natural compound.

  11. Randomised clinical trial of early specialist palliative care plus standard care versus standard care alone in patients with advanced cancer

    DEFF Research Database (Denmark)

    Groenvold, Mogens; Petersen, Morten Aagaard; Damkier, Anette

    2017-01-01

    BACKGROUND: Beneficial effects of early palliative care have been found in advanced cancer, but the evidence is not unequivocal. AIM: To investigate the effect of early specialist palliative care among advanced cancer patients identified in oncology departments. SETTING/PARTICIPANTS: The Danish...... Palliative Care Trial (DanPaCT) (ClinicalTrials.gov NCT01348048) is a multicentre randomised clinical trial comparing early referral to a specialist palliative care team plus standard care versus standard care alone. The planned sample size was 300. At five oncology departments, consecutive patients...

  12. Advances in Bio-Optical Imaging for the Diagnosis of Early Oral Cancer

    Directory of Open Access Journals (Sweden)

    Ivan Keogh

    2011-07-01

    Full Text Available Oral cancer is among the most common malignancies worldwide, therefore early detection and treatment is imperative. The 5-year survival rate has remained at a dismal 50% for the past several decades. The main reason for the poor survival rate is the fact that most of the oral cancers, despite the general accessibility of the oral cavity, are not diagnosed until the advanced stage. Early detection of the oral tumors and its precursor lesions may be the most effective means to improve clinical outcome and cure most patients. One of the emerging technologies is the use of non-invasive in vivo tissue imaging to capture the molecular changes at high-resolution to improve the detection capability of early stage disease. This review will discuss the use of optical probes and highlight the role of optical imaging such as autofluorescence, fluorescence diagnosis (FD, laser confocal endomicroscopy (LCE, surface enhanced Raman spectroscopy (SERS, optical coherence tomography (OCT and confocal reflectance microscopy (CRM in early oral cancer detection. FD is a promising method to differentiate cancerous lesions from benign, thus helping in the determination of adequate resolution of surgical resection margin. LCE offers in vivo cellular imaging of tissue structures from surface to subsurface layers and has demonstrated the potential to be used as a minimally invasive optical biopsy technique for early diagnosis of oral cancer lesions. SERS was able to differentiate between normal and oral cancer patients based on the spectra acquired from saliva of patients. OCT has been used to visualize the detailed histological features of the oral lesions with an imaging depth down to 2–3 mm. CRM is an optical tool to noninvasively image tissue with near histological resolution. These comprehensive diagnostic modalities can also be used to define surgical margin and to provide a direct assessment of the therapeutic effectiveness.

  13. An ERP investigation of orthographic priming with superset primes.

    Science.gov (United States)

    Ktori, Maria; Midgley, Katherine; Holcomb, Phillip J; Grainger, Jonathan

    2015-01-12

    Prime stimuli formed by inserting unrelated letters in a given target word (called "superset" primes) provide a means to modify the relative positions of the letters shared by prime and target. Here we examined the time-course of superset priming effects in an ERP study using the sandwich-priming paradigm. We compared the effects of superset primes formed by the insertion of unrelated letters (e.g., maurkdet-MARKET), or by the insertion of hyphens (e.g., ma-rk-et-MARKET), with identity priming (e.g., market-MARKET), all measured relative to unrelated control primes. Behavioral data revealed significantly greater priming in the hyphen-insert condition compared with the letter-insert condition. In the ERP signal, letter-insert priming emerged later than hyphen-insert priming and produced a reversed priming effect in the N400 time-window compared with the more typical N400 priming effects seen for both hyphen-insert priming and identity priming. The different pattern of priming effects seen for letter-insert primes and hyphen-insert primes suggests that compared with identity priming, letter superset priming reflects the joint influence of: (1) a disruption in letter position information, and (2) an inhibitory influence of mismatching letters.

  14. Dynamics of structural priming

    OpenAIRE

    Malhotra, Gaurav

    2009-01-01

    This thesis is about how our syntactic choice changes with linguistic experience. Studies on syntactic priming show that our decisions are influenced by sentences that we have recently heard or recently spoken. They also show that not all sentences have an equal amount of influence; that repetition of verbs increases priming (the lexical-boost effect) and that some verbs are more susceptible to priming than others. This thesis explores how and why syntactic decisions change with time and what...

  15. Priming semantico e museografia

    OpenAIRE

    Annalisa Banzi

    2012-01-01

    Il priming è una tipologia di memoria implicita che facilita l’apprendimento di stimoli di diversa natura (stimoli visivi, semantici, etc.). Un allestimento museale che adotti strumenti basati sul priming potrebbe aiutare il pubblico a selezionare i contenuti relativi agli oggetti esposti. In questo articolo viene descritta l’applicazione del priming semantico allo spazio museale. Questa operazione in prima battutta potrebbe essere letta come una mancanza di fiducia nelle capacità cognitive d...

  16. Live imaging of X chromosome reactivation dynamics in early mouse development can discriminate naïve from primed pluripotent stem cells.

    Science.gov (United States)

    Kobayashi, Shin; Hosoi, Yusuke; Shiura, Hirosuke; Yamagata, Kazuo; Takahashi, Saori; Fujihara, Yoshitaka; Kohda, Takashi; Okabe, Masaru; Ishino, Fumitoshi

    2016-08-15

    Pluripotent stem cells can be classified into two distinct states, naïve and primed, which show different degrees of potency. One difficulty in stem cell research is the inability to distinguish these states in live cells. Studies on female mice have shown that reactivation of inactive X chromosomes occurs in the naïve state, while one of the X chromosomes is inactivated in the primed state. Therefore, we aimed to distinguish the two states by monitoring X chromosome reactivation. Thus far, X chromosome reactivation has been analysed using fixed cells; here, we inserted different fluorescent reporter gene cassettes (mCherry and eGFP) into each X chromosome. Using these knock-in 'Momiji' mice, we detected X chromosome reactivation accurately in live embryos, and confirmed that the pluripotent states of embryos were stable ex vivo, as represented by embryonic and epiblast stem cells in terms of X chromosome reactivation. Thus, Momiji mice provide a simple and accurate method for identifying stem cell status based on X chromosome reactivation.

  17. Prime tight frames

    DEFF Research Database (Denmark)

    Lemvig, Jakob; Miller, Christopher; Okoudjou, Kasso A.

    2014-01-01

    to suggest effective analysis and synthesis computation strategies for such frames. Finally, we describe all prime frames constructed from the spectral tetris method, and, as a byproduct, we obtain a characterization of when the spectral tetris construction works for redundancies below two.......We introduce a class of finite tight frames called prime tight frames and prove some of their elementary properties. In particular, we show that any finite tight frame can be written as a union of prime tight frames. We then characterize all prime harmonic tight frames and use thischaracterization...

  18. F1000 prime reports

    National Research Council Canada - National Science Library

    F1000 Prime is a revolutionary post-publication peer review service that comprehensively and systematically highlights and recommends the most interesting articles published in the biomedical sciences...

  19. Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods

    Directory of Open Access Journals (Sweden)

    Ahmed R

    2014-03-01

    Full Text Available Rafay Ahmed,1 Matthew J Oborski,2 Misun Hwang,1 Frank S Lieberman,3 James M Mountz11Department of Radiology, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; 3Department of Neurology and Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12–15 months for glioblastomas and 2–5 years for anaplastic gliomas. However, recent advances in imaging and quantitative analysis of image data have led to earlier diagnosis of tumors and tumor response to therapy, providing oncologists with a greater time window for therapy management. In addition, improved understanding of tumor biology, genetics, and resistance mechanisms has enhanced surgical techniques, chemotherapy methods, and radiotherapy administration. After proper diagnosis and institution of appropriate therapy, there is now a vital need for quantitative methods that can sensitively detect malignant glioma response to therapy at early follow-up times, when changes in management of nonresponders can have its greatest effect. Currently, response is largely evaluated by measuring magnetic resonance contrast and size change, but this approach does not take into account the key biologic steps that precede tumor size reduction. Molecular imaging is ideally suited to measuring early response by quantifying cellular metabolism, proliferation, and apoptosis, activities altered early in treatment. We expect that successful integration of quantitative imaging biomarker assessment into the early phase of clinical trials could provide a novel approach for testing new therapies

  20. Priming Ability Emotional Intelligence

    Science.gov (United States)

    Schutte, Nicola S.; Malouff, John M.

    2012-01-01

    Two studies examined whether priming self-schemas relating to successful emotional competency results in better emotional intelligence performance. In the first study participants were randomly assigned to a successful emotional competency self-schema prime condition or a control condition and then completed an ability measure of emotional…

  1. Priming Ability Emotional Intelligence

    Science.gov (United States)

    Schutte, Nicola S.; Malouff, John M.

    2012-01-01

    Two studies examined whether priming self-schemas relating to successful emotional competency results in better emotional intelligence performance. In the first study participants were randomly assigned to a successful emotional competency self-schema prime condition or a control condition and then completed an ability measure of emotional…

  2. Discovery: Prime Numbers

    Science.gov (United States)

    de Mestre, Neville

    2008-01-01

    Prime numbers are important as the building blocks for the set of all natural numbers, because prime factorisation is an important and useful property of all natural numbers. Students can discover them by using the method known as the Sieve of Eratosthenes, named after the Greek geographer and astronomer who lived from c. 276-194 BC. Eratosthenes…

  3. Building Numbers from Primes

    Science.gov (United States)

    Burkhart, Jerry

    2009-01-01

    Prime numbers are often described as the "building blocks" of natural numbers. This article shows how the author and his students took this idea literally by using prime factorizations to build numbers with blocks. In this activity, students explore many concepts of number theory, including the relationship between greatest common factors and…

  4. Recognizing plant defense priming

    NARCIS (Netherlands)

    Martinez-Medina, A.; Flors, V.; Heil, M.; Mauch-Mani, B.; Pieterse, C.M.J.; Pozo, M.J.; Ton, J.; Van Dam, N.M.; Conrath, U.

    2016-01-01

    Defense priming conditions diverse plant species for the superinduction of defense, often resulting in enhanced pest and disease resistance and abiotic stress tolerance. Here, we propose a guideline that might assist the plant research community in a consistent assessment of defense priming in plant

  5. The semantic priming project.

    Science.gov (United States)

    Hutchison, Keith A; Balota, David A; Neely, James H; Cortese, Michael J; Cohen-Shikora, Emily R; Tse, Chi-Shing; Yap, Melvin J; Bengson, Jesse J; Niemeyer, Dale; Buchanan, Erin

    2013-12-01

    Speeded naming and lexical decision data for 1,661 target words following related and unrelated primes were collected from 768 subjects across four different universities. These behavioral measures have been integrated with demographic information for each subject and descriptive characteristics for every item. Subjects also completed portions of the Woodcock-Johnson reading battery, three attentional control tasks, and a circadian rhythm measure. These data are available at a user-friendly Internet-based repository ( http://spp.montana.edu ). This Web site includes a search engine designed to generate lists of prime-target pairs with specific characteristics (e.g., length, frequency, associative strength, latent semantic similarity, priming effect in standardized and raw reaction times). We illustrate the types of questions that can be addressed via the Semantic Priming Project. These data represent the largest behavioral database on semantic priming and are available to researchers to aid in selecting stimuli, testing theories, and reducing potential confounds in their studies.

  6. Differential precision of corneal Pentacam HR measurements in early and advanced keratoconus.

    Science.gov (United States)

    Flynn, Tom H; Sharma, Daya P; Bunce, Catey; Wilkins, Mark R

    2016-09-01

    Serial Scheimpflug corneal tomography to monitor the progression of keratoconus has become standard practice in most countries where corneal cross-linking is available. The tomographic definitions of progression are, however, poorly defined. The aims of this study were: (a) to estimate the 95% limits of intraobserver and interobserver agreement of corneal shape parameters on Pentacam in patients with keratoconus and (b) to investigate whether these limits of agreement varied according to disease severity. 96 adult patients with keratoconus and no corneal scarring or history of previous surgery were recruited from a corneal clinic in a tertiary ophthalmology hospital. One eye of each subject was scanned twice by each of the two observers with the Pentacam HR. 95% limits of intraobserver and interobserver agreement for K1, K2, Kmax and corneal thickness at the thinnest corneal location (TCT) were calculated. Reproducibility of keratometry measures was better for early keratoconus than advanced keratoconus. In patients of Pentacam-derived Krumeich stage 1 or 2, the 95% limits of interobserver agreement for Kmax were from -0.90 to 1.01. In patients of Pentacam-derived Krumeich stage >2, the 95% limits of interobserver agreement for Kmax were from -3.71 to 3.86. Keratometric measurements on Pentacam HR are less reproducible in advanced keratoconus than in early keratoconus. In patients of Pentacam-derived Krumeich stage 1 or 2, an increase in K1, K2 or Kmax of more than 1 dioptre is likely to represent the real change in the corneal shape. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  7. Prime Submodules and Flat Modules

    Institute of Scientific and Technical Information of China (English)

    A.AZIZI

    2007-01-01

    In this paper, some characterizations of prime submodules in fiat modules and, particularly,in free modules are given. Furthermore, the height of prime submodules and some saturated chain of prime submodules are also given.

  8. [A case of early gastric cancer completely responding to adjuvant chemotherapy for advanced colon cancer].

    Science.gov (United States)

    Tanaka, Ryo; Kameyama, Hitoshi; Nakano, Mae; Ichikawa, Hiroshi; Hanyu, Takaaki; Nakano, Masato; Ishikawa, Takashi; Shimada, Yoshifumi; Sakata, Jun; Kobayashi, Takashi; Kosugi, Shinichi; Minagawa, Masahiro; Koyama, Yu; Wakai, Toshifumi

    2014-11-01

    A 70-year-old man was referred to our hospital with ascending colon cancer (cT3N1M0, Stage IIIa), which was found during examinations following a positive fecal occult blood test. The patient was also diagnosed with early gastric cancer (cT1a, N0, M0, Stage IA)during a preoperative gastroscopy examination. A laparoscopically assisted right colectomy and D3 lymphadenectomy was performed for the ascending colon cancer. The postoperative pathological diagnosis was Stage IIIb (pT3N2), he was administered in combination with capecitabine plus oxaliplatin (CapeOX) as adjuvant chemotherapy before the treatment for the colon cancer. After 6 months of adjuvant chemotherapy, we were unable to detect any gastric lesions at the same location using gastroscopy, and so diagnosed a clinical complete response. A follow-up gastroscopy 6 months later showed the same findings. The patient has had no recurrence of gastric cancer for 18 months after the initial operation. He will continue to be followed up closely using gastroscopy. In this case, CapeOX as adjuvant chemotherapy for advanced colon cancer was also effective for early gastric cancer.

  9. A Relation between Prime Numbers and Twin Prime Numbers

    OpenAIRE

    2001-01-01

    Every mathematician has been concerned with prime numbers, and has metwith mysterious surprises about them. Besides intuition, using empirical methods has an important role to findrelations between prime numbers. A relation between any prime numberand any twin prime number has been obtained.

  10. Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults.

    Science.gov (United States)

    Bisson, Gregory P; Ramchandani, Ritesh; Miyahara, Sachiko; Mngqibisa, Rosie; Matoga, Mitch; Ngongondo, McNeil; Samaneka, Wadzanai; Koech, Lucy; Naidoo, Kogieleum; Rassool, Mohammed; Kirui, Fredrick; Banda, Peter; Mave, Vidya; Kadam, Dileep; Leger, Paul; Henostroza, German; Manabe, Yukari C; Bao, Jing; Kumwenda, Johnstone; Gupta, Amita; Hosseinipour, Mina C

    2017-07-24

    Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear. We used data from a multi-site randomized trial comparing empiric versus preventive TB therapy in HIV-infected adults initiating ART with CD4 counts <50 cells/mm to evaluate risk factors for death within 48 weeks after ART initiation. Cox proportional hazards models were fit to evaluate characteristics present at baseline and at 4 weeks after ART initiation, including the week 4 CD4 cell response and new opportunistic infections (OIs). Of 850 enrolled, the median pre-ART CD4 count was 18 cells/mm and 67 (7.9%) died. Baseline risk factors for death included lymphadenopathy, lower CD4 count, lower serum albumin, high white blood cell (WBC) count, elevated neutrophil percent, and lower hemoglobin. Among 746 participants with data at week 4, the median changes in CD4 count and viral load for those who died (n = 43) vs. survived were 26 vs. 56 cells/mm and -2.7 vs. -2.7 log10 copies/mL, respectively. Each 20 cell/mm lower change in week 4 CD4 count was associated with a 20% increased risk of post week-4 mortality (adj. HR 1.20, 1.01-1.42, p = .038). Evidence of active infection and sub-optimal immunologic response during the first month of ART are associated with death in the first year after ART initiation in those with advanced HIV disease taking TB preventative therapy. Strategies to reduce early mortality in this population warrant further investigation.

  11. Early experience with digital advance care planning and directives, a novel consumer-driven program.

    Science.gov (United States)

    Fine, Robert L; Yang, Zhiyong; Spivey, Christy; Boardman, Bonnie; Courtney, Maureen

    2016-07-01

    Barriers to traditional advance care planning (ACP) and advance directive (AD) creation have limited the promise of ACP/AD for individuals and families, the healthcare team, and society. Our objectives were to determine the results of a digital ACP/AD through which consumers create, store, locate, and retrieve their ACP/AD at no charge and with minimal physician involvement, and the ACP/AD can be integrated into the electronic health record. The authors chose 900 users of MyDirectives, a digital ACP/AD tool, to achieve proportional representation of all 50 states by population size and then reviewed their responses. The 900 participants had an average age of 50.8 years (SD = 16.6); 84% of the men and 91% of the women were in self-reported good health when signing their ADs. Among the respondents, 94% wanted their physicians to consult a supportive and palliative care team if they were seriously ill; nearly 85% preferred cessation of life-sustaining treatments during their final days; 76% preferred to spend their final days at home or in a hospice; and 70% would accept attempted cardiopulmonary resuscitation in limited circumstances. Most respondents wanted an autopsy under certain conditions, and 62% wished to donate their organs. In conclusion, analysis of early experience with this ACP/AD platform demonstrates that individuals of different ages and conditions can engage in an interrogatory process about values, develop ADs that are more nuanced than traditional paper-based ADs in reflecting those values, and easily make changes to their ADs. Online ADs have the potential to remove barriers to ACP/AD and thus further improve patient-centered end-of-life care.

  12. An evaluation of early or delayed adjuvant chemotherapy in premenopausal patients with advances breast cancer undergoing oophorectomy: a later analysis.

    Science.gov (United States)

    Ahmann, D L; Green, S J; Bisel, H F; Ingle, J N; Hahn, R G; Lee, R A; Edmonson, J H

    1982-08-01

    In 1977 we reported our results of an ongoing randomized clinical trial evaluating early or delayed adjuvant chemotherapy utilizing 5-flourouracil, cytoxan and prednisone in premenopausal patients with recurrent or advanced breast cancer. At that time the group receiving early systemic chemotherapy was shown to have an improved progression-free interval and appeared to have a trend toward improved survival. The results of subsequent analysis after over 4 more years of follow-up indicate however, that while early employment of systemic chemotherapy does indeed prolong the progression-free interval, and while this advantage has been maintained, there is no survival advantage shown for either group of patients.

  13. Early α-fetoprotein response predicts survival in patients with advanced hepatocellular carcinoma treated with sorafenib

    Directory of Open Access Journals (Sweden)

    Lee SH

    2015-04-01

    in AFP responders than in non-responders (72.1% vs 47.0%, respectively; P=0.007. In a sub-group with SD, OS (median 12.7 vs 5.8 months, respectively and PFS (median 9.1 vs 3.7 months, respectively were significantly longer in AFP responders than in non-responders (all P<0.05. Conclusion: Early AFP response may be useful for predicting survival in patients with advanced HCC treated with sorafenib. Keywords: α-fetoprotein, hepatocellular carcinoma, response, prognosis, treatment outcome, sorafenib

  14. Imaging in the evaluation and follow-up of early and advanced breast cancer: When, why, and how often?

    Science.gov (United States)

    Bychkovsky, Brittany L; Lin, Nancy U

    2017-02-01

    Imaging in the evaluation and follow-up of patients with early or advanced breast cancer is an important aspect of cancer care. The role of imaging in breast cancer depends on the goal and should only be performed to guide clinical decisions. Imaging is valuable if a finding will change the course of treatment and improve outcomes, whether this is disease-free survival, overall survival or quality-of-life. In the last decade, imaging is often overused in oncology and contributes to rising healthcare costs. In this context, we review the data that supports the appropriate use of imaging for breast cancer patients. We will discuss: 1) the optimal use of staging imaging in both early (Stage 0-II) and locally advanced (Stage III) breast cancer, 2) the role of surveillance imaging to detect recurrent disease in Stage 0-III breast cancer and 3) how patients with metastatic breast cancer should be followed with advanced imaging.

  15. An evaluation of early or delayed adjuvant chemotherapy in premenopausal patients with advanced breast cancer undergoing oophorectomy.

    Science.gov (United States)

    Ahmann, D L; O'Connell, M J; Hahn, R G; Bisel, H F; Lee, R A; Edmonson, J H

    1977-08-18

    We treated randomly 75 premenopausal patients with advanced breast cancer with combination chemotherapy (5-fluorouracil, cyclophosphamide and prednisone), either as an early adjunct to oophorectomy or as a delayed treatment upon appearance of progressive metastatic disease after operation. The group receiving early systemic chemotherapy enjoyed an improved response rate, an improved survival rate and, most importantly, an improved progression-free interval (median of 53 versus 17 weeks). With the exclusion of the group with early (within three weeks after oophorectomy) progression, the progression-free intervals had a median duration of 77 weeks in the early-treatment group versus 33 weeks in the control group. The early-progression group did exceedingly poorly, although systemic chemotherapy was employed at that juncture, having a median survival of 22 weeks as compared to 144 weeks in the immediate-treatment group and 105 weeks in the control group.

  16. Application of Advanced Wide Area Early Warning Systems with Adaptive Protection

    Energy Technology Data Exchange (ETDEWEB)

    Blumstein, Carl [Univ. of California, Berkeley, CA (United States); Cibulka, Lloyd [Univ. of California, Berkeley, CA (United States); Thorp, James [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Centeno, Virgilio [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); King, Roger [Mississippi State Univ., Mississippi State, MS (United States); Reeves, Kari [Mississippi State Univ., Mississippi State, MS (United States); Ashrafi, Frank [Southern California Edison Co., Rosemead, CA (United States); Madani, Vahid [Pacific Gas & Electric Co., San Francisco, CA (United States)

    2014-09-30

    Recent blackouts of power systems in North America and throughout the world have shown how critical a reliable power system is to modern societies, and the enormous economic and societal damage a blackout can cause. It has been noted that unanticipated operation of protection systems can contribute to cascading phenomena and, ultimately, blackouts. This project developed and field-tested two methods of Adaptive Protection systems utilizing synchrophasor data. One method detects conditions of system stress that can lead to unintended relay operation, and initiates a supervisory signal to modify relay response in real time to avoid false trips. The second method detects the possibility of false trips of impedance relays as stable system swings “encroach” on the relays’ impedance zones, and produces an early warning so that relay engineers can re-evaluate relay settings. In addition, real-time synchrophasor data produced by this project was used to develop advanced visualization techniques for display of synchrophasor data to utility operators and engineers.

  17. Formation of early and advanced Maillard reaction products correlates to the ripening of cheese.

    Science.gov (United States)

    Spanneberg, Robert; Salzwedel, Grit; Glomb, Marcus A

    2012-01-18

    The present study deals with the characterization of the ripening of cheese. A traditional German acid curd cheese was ripened under defined conditions at elevated temperature, and protein and amino acid modifications were investigated. Degree of proteolysis and analysis of early [Amadori compound furosine (6)] and advanced [N(ε)-carboxymethyllysine (4), N(ε)-carboxyethyllysine (5)] Maillard reaction products confirmed the maturation to proceed from the rind to the core of the cheese. Whereas 6 was decreased, 4 and 5 increased over time. Deeper insight into the Maillard reaction during the ripening of cheese was achieved by the determination of selected α-dicarbonyl compounds. Especially methylglyoxal (2) showed a characteristic behavior during storage of the acid curd cheese. Decrease of this reactive structure was directly correlated to the formation of 5. To extend the results of experimental ripening to commercial cheeses, different aged Gouda types were investigated. Maturation times of the samples ranged from 6 to 8 weeks (young) to more than 1 year (aged). Again, increase of 5 and decrease of 2 were able to describe the ripening of this rennet coagulated cheese. Therefore, both chemical parameters are potent markers to characterize the degree of maturation, independent of coagulation.

  18. Heterologous Prime-Boost Vaccination

    OpenAIRE

    Lu, Shan

    2009-01-01

    An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost. Heterologous prime-boost represents a new way of immunization and will stimulate better understanding on the...

  19. The Set of Prime Numbers

    CERN Document Server

    Iovane, Gerardo

    2007-01-01

    In this work we show that the prime distribution is deterministic. Indeed the set of prime numbers P can be expressed in terms of two subsets of N using three specific selection rules, acting on two sets of prime candidates. The prime candidates are obtained in terms of the first perfect number. The asymptotic behaviour is also considered. We obtain for the first time an explicit relation for generating the full set P of prime numbers smaller than n or equal to n.

  20. Effect of low-dose cytarabine, homoharringtonine and granulocyte colony-stimulating factor priming regimen on patients with advanced myelodysplastic syndrome or acute myeloid leukemia transformed from myelodysplastic syndrome.

    Science.gov (United States)

    Wu, Lingyun; Li, Xiao; Su, Jiying; Chang, Chunkang; He, Qi; Zhang, Xi; Xu, Li; Song, Luxi; Pu, Quan

    2009-09-01

    A total of 32 patients (25 with advanced MDS and 7 with t-AML) were enrolled in this study to evaluate the efficacy and toxicity of the low-dose cytarabine and homoharringtonine in combination with granulocyte colony-stimulating factor (G-CSF) (CHG protocol) in patients with advanced myelodysplastic syndromes (MDS) or MDS-transformed acute myeloid leukemia (t-AML). All the patients were administered the CHG regimen comprising low-dose cytarabine (25 mg/day, intravenous continuous infusion, days 1-14), homoharringtonine (1 mg/day, intravenous continuous infusion, days 1-14), and G-CSF (300 microg/day, subcutaneous injection, days 0-14, interrupted when the peripheral white blood cell count reached >20 x 10(9)/L). The overall response rate was 71.9% after the administration of one course of the CHG regimen. Of the 32 patients, 15 (46.9%) achieved complete remission (CR) and 8 (25%) achieved partial remission (PR). This regimen was followed by a post-remission therapy that included conventional chemotherapy, when CR was achieved. Of the patients with CR who just received post-remission regimens as homoharringtonine and cytarabine (HA) and daunorubicin and cytarabine (DA) 6 relapsed rapidly and just had a mean 6.1 months of CR. Otherwise, the other 8 out of 14 patients with CR alternatively received subsequent chemotherapy, which combined mitoxantrone, idarubicin, pirarubicin, or aclarubicin with cytarabine. The mean CR duration of the 8 patients had reached 10.6 months, and 5 of the 8 still kept a continuous CR. The median overall survival (OS) was 18.2 months. There were no statistically significant differences for CR, PR, and OS when the patients were grouped by age, blasts in bone marrow, and karyotypes, respectively. No treatment-related deaths were observed. Myelosuppression was mild to moderate, and no severe non-hematological toxicity was observed. Thus, a CHG priming regimen as an induction therapy was well tolerated and effective in patients with advanced MDS

  1. Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA decline.

    Science.gov (United States)

    Kilby, J Michael; Lee, Ha Youn; Hazelwood, J Darren; Bansal, Anju; Bucy, R Patterson; Saag, Michael S; Shaw, George M; Acosta, Edward P; Johnson, Victoria A; Perelson, Alan S; Goepfert, Paul A

    2008-05-11

    Compare the initial phases of virologic decay when acute/early and advanced HIV-infected adults are administered the same treatment regimen. Mathematical modeling of a previously completed prospective treatment pilot study involving treatment-naive patients with early and advanced immunosuppression. We analyzed data from a treatment protocol in which 18 individuals with acute or recent HIV-1 seroconversion and six patients with advanced AIDS were administered the same four-drug antiretroviral regimen. Initial treatment responses were compared by fitting a mathematical model to frequent viral load measurements in order to calculate the first and second phase kinetics of viral clearance, and also by comparing viral load suppression over 24 weeks. Patients were also comprehensively compared in terms of protease inhibitor drug levels, HIV-specific immune responses at baseline, and the presence of drug resistance-conferring mutations. There was no statistically meaningful difference in first phase clearance of comparable high-level viremia in the two groups, whether protease inhibitor levels were inserted into the model or 100% antiviral drug effectiveness was assumed. In contrast, acute/early patients had inferior sustained responses than advanced patients, reflecting erratic adherence. Despite many years of intervening immune destruction, the initial virologic decay on therapy appears to be the same at the extremes of the HIV disease spectrum.

  2. Reversing Early Retirement in Advanced Welfare EconomiesA Paradigm Shift to Overcome Push and Pull Factors

    Directory of Open Access Journals (Sweden)

    Bernhard Ebbinghaus

    2013-12-01

    Full Text Available Recent reform efforts of advanced welfare states have attempted to reverse trends in early retirement and increase the statutory retirement age. This paradigm shift often occurred against the protest of unions, firms and their employees. As a consequence of expanding welfare states and as response to economic challenges since the 1970s early exit from work has become a widespread practice. Early retirement has been part of Continental Europe’s welfare without work problem, while the Scandinavian welfare states, the Anglophone liberal economies and the Japanese welfare society were able to maintain higher levels of employment for older workers. Since the 1990s, an international consensus to reverse early exit from work emerged among international organisations and national policy experts. Based on a comparative historical analysis of selected OECD countries, this study analyses the cross-national variations in the institutionalisation of early exit regimes and its recent reversal using macro-indictors on early exit trends and stylised information on institutional arrangements. Comparing the interaction of social policy and economic institutions, it reviews the cross-national differences in welfare state “pull” and economic “push” factors that have contributed to early exit from work and discusses the likely impact of welfare retrenchment and assesses the importance of “retention” factors such as activation policies for decreasing early exit from work.

  3. Efficient prime counting and the Chebyshev primes

    CERN Document Server

    Planat, Michel

    2011-01-01

    The function $\\epsilon(x)=li(x)-\\pi(x)$ is known to be positive up to the (very large) Skewes' number. Besides, according to Robin's work, the functions $\\epsilon_{\\theta}(x)=li[\\theta(x)]-\\pi(x)$ and $\\epsilon_{\\psi}(x)=li[\\psi(x)]-\\pi(x)$ are positive if and only if Riemann hypothesis (RH) holds (the first and the second Chebyshev function are $\\theta(x)=\\sum_{p \\le x} \\log p$ and $\\psi(x)=\\sum_{n=1}^x \\Lambda(n)$, respectively, $li(x)$ is the logarithmic integral, $\\mu(n)$ and $\\Lambda(n)$ are the M\\"obius and the Von Mangoldt functions). Negative jumps in the above functions $\\epsilon$, $\\epsilon_{\\theta}$ and $\\epsilon_{\\psi}$ may potentially occur only at $x+1 \\in \\mathcal{P}$ (the set of primes). One denotes $j_p=li(p)-li(p-1)$ and one investigates the jumps $j_p$, $j_{\\theta(p)}$ and $j_{\\psi(p)}$. In particular, $j_p1$ for $p<10^{11}$. Besides, $j_{\\psi(p)}<1$ for any odd $p \\in \\mathcal{Ch}$, an infinite set of so-called {\\it Chebyshev primes} with partial list ${109, 113, 139, 181, 197, 199, ...

  4. Multisensory Flavor Priming

    DEFF Research Database (Denmark)

    Dijksterhuis, Garmt Bernard

    2016-01-01

    Flavor is multisensory; several interacting sensory systems-taste, smell, and mouthfeel-together comprise "flavor," making it a cognitively constructed percept rather than a bottom-up sensory one. In this chapter, some of the complications this entails for flavor priming are introduced, along...... with a taxonomy of different priming situations. In food-related applications of flavor, both bottom-up (sensory) as well as top-down (expectations) processes are at play. Most of the complex interactions that this leads to take place outside the awareness of the perceiving subject. A model is presented where...... many, past and current, aspects (sensory, surroundings, social, somatic, sentimental) of a (flavor) perception, together result in the perception of a flavor, its liking. or its choice. This model borrows on ideas from priming, situated/embodied cognition, and (food-related) perception....

  5. Early Detection of Ovarian Cancer with Conventional and Contrast-Enhanced Transvaginal Sonography: Recent Advances and Potential Improvements

    Directory of Open Access Journals (Sweden)

    Arthur C. Fleischer

    2012-01-01

    Full Text Available Recently, there have been several major technical advances in the sonographic diagnosis of ovarian cancer in its early stages. These include improved assessment of tumor morphology with transvaginal sonography (TVS, and detection and characterization of tumor neovascularity with transvaginal color Doppler sonography (TV-CDS and contrast-enhanced transvaginal sonography (CE-TVS. This paper will discuss and illustrate these improvements and describe how they enhance detection of early-stage ovarian cancer. Our initial experience with parametric mapping of CE-TVS will also be mentioned.

  6. Early life exposure to chronic intermittent Hypoxia Primes Increased Susceptibility to Hypoxia-Induced Weakness in Rat Sternohyoid Muscle during adulthood.

    LENUS (Irish Health Repository)

    McDonald, Fiona B

    2016-03-01

    Intermittent hypoxia is a feature of apnea of prematurity (AOP), chronic lung disease, and sleep apnea. Despite the clinical relevance, the long-term effects of hypoxic exposure in early life on respiratory control are not well defined. We recently reported that exposure to chronic intermittent hypoxia (CIH) during postnatal development (pCIH) causes upper airway muscle weakness in both sexes, which persists for several weeks. We sought to examine if there are persistent sex-dependent effects of pCIH on respiratory muscle function into adulthood and\\/or increased susceptibility to re-exposure to CIH in adulthood in animals previously exposed to CIH during postnatal development. We hypothesized that pCIH would cause long-lasting muscle impairment and increased susceptibility to subsequent hypoxia. Within 24 h of delivery, pups and their respective dams were exposed to CIH: 90 s of hypoxia reaching 5% O2 at nadir; once every 5 min, 8 h per day for 3 weeks. Sham groups were exposed to normoxia in parallel. Three groups were studied: sham; pCIH; and pCIH combined with adult CIH (p+aCIH), where a subset of the pCIH-exposed pups were re-exposed to the same CIH paradigm beginning at 13 weeks. Following gas exposures, sternohyoid and diaphragm muscle isometric contractile and endurance properties were examined ex vivo. There was no apparent lasting effect of pCIH on respiratory muscle function in adults. However, in both males and females, re-exposure to CIH in adulthood in pCIH-exposed animals caused sternohyoid (but not diaphragm) weakness. Exposure to this paradigm of CIH in adulthood alone had no effect on muscle function. Persistent susceptibility in pCIH-exposed airway dilator muscle to subsequent hypoxic insult may have implications for the control of airway patency in adult humans exposed to intermittent hypoxic stress during early life.

  7. Early Life Exposure to Chronic Intermittent Hypoxia Primes Increased Susceptibility to Hypoxia-Induced Weakness in Rat Sternohyoid Muscle During Adulthood

    Directory of Open Access Journals (Sweden)

    Fiona B Mcdonald

    2016-03-01

    Full Text Available Intermittent hypoxia is a feature of apnea of prematurity, chronic lung disease and sleep apnea. Despite the clinical relevance, the long-term effects of hypoxic exposure in early life on respiratory control are not well defined. We recently reported that exposure to chronic intermittent hypoxia (CIH during postnatal development (pCIH causes upper airway muscle weakness in both sexes, which persists for several weeks. We sought to examine if there are persistent sex-dependent effects of pCIH on respiratory muscle function into adulthood and/or increased susceptibility to re-exposure to CIH in adulthood in animals previously exposed to CIH during postnatal development. We hypothesized that pCIH would cause long-lasting muscle impairment and increased susceptibility to subsequent hypoxia. Within 24 hours of delivery, pups and their respective dams were exposed to CIH: 90s of hypoxia reaching 5% O2 at nadir; once every 5 min, 8 hrs per day for 3 weeks. Sham groups were exposed to normoxia in parallel. Three groups were studied: sham; pCIH; and pCIH combined with adult CIH (p+aCIH, where a subset of the pCIH-exposed pups were re-exposed to the same CIH paradigm beginning at 13 weeks. Following gas exposures, sternohyoid and diaphragm muscle isometric contractile and endurance properties were examined ex vivo. There was no apparent lasting effect of pCIH on respiratory muscle function in adults. However, in both males and females, re-exposure to CIH in adulthood in pCIH-exposed animals caused sternohyoid (but not diaphragm weakness. Exposure to this paradigm of CIH in adulthood alone had no effect on muscle function. Persistent susceptibility in pCIH-exposed airway dilator muscle to subsequent hypoxic insult may have implications for the control of airway patency in adult humans exposed to intermittent hypoxic stress during early life.

  8. Adding irrelevant information to the content prime reduces the prime-induced unmasking effect on speech recognition.

    Science.gov (United States)

    Wu, Meihong; Li, Huahui; Gao, Yayue; Lei, Ming; Teng, Xiangbin; Wu, Xihong; Li, Liang

    2012-01-01

    Presenting the early part of a nonsense sentence in quiet improves recognition of the last keyword of the sentence in a masker, especially a speech masker. This priming effect depends on higher-order processing of the prime information during target-masker segregation. This study investigated whether introducing irrelevant content information into the prime reduces the priming effect. The results showed that presenting the first four syllables (not including the second and third keywords) of the three-keyword target sentence in quiet significantly improved recognition of the second and third keywords in a two-talker-speech masker but not a noise masker, relative to the no-priming condition. Increasing the prime content from four to eight syllables (including the first and second keywords of the target sentence) further improved recognition of the third keyword in either the noise or speech masker. However, if the last four syllables of the eight-syllable prime were replaced by four irrelevant syllables (which did not occur in the target sentence), all the prime-induced speech-recognition improvements disappeared. Thus, knowing the early part of the target sentence mainly reduces informational masking of target speech, possibly by helping listeners attend to the target speech. Increasing the informative content of the prime further improves target-speech recognition probably by reducing the processing load. The reduction of the priming effect by adding irrelevant information to the prime is not due to introducing additional masking of the target speech. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Prospects for early localization of gravitational-wave signals from compact binary coalescences with advanced detectors

    OpenAIRE

    Manzotti, Alessandro; Dietz, Alexander

    2012-01-01

    A leading candidate source of detectable gravitational waves is the inspiral and merger of pairs of stellar-mass compact objects. The advanced LIGO and advanced Virgo detectors will allow scientists to detect inspiral signals from more massive systems and at earlier times in the detector band, than with first generation detectors. The signal from a coalescence of two neutron stars is expected to stay in the sensitive band of advanced detectors for several minutes, thus allowing detection befo...

  10. The significance of early changes in serum alkaline-phosphatase levels following endocrine treatment in patients with advanced prostate cancer

    Directory of Open Access Journals (Sweden)

    Aditya Pareek

    2000-01-01

    Conclusions: A significant proportion of patients with advanced carcinoma of the prostate have flare in SAP le-vels soon after initiating the treatment. We confirm that the flare activity in SAP levels is a negative prognostic indicator and it is possible to identify early treatment fail-ures by frequent measurements of SAP levels during first 6 weeks of commencing the therapy. The significance of SAP fare and androgen resistance is discussed.

  11. Detecting Priming News Events

    CERN Document Server

    Wu, Di; Yu, Jeffrey Xu; Liu, Zheng

    2012-01-01

    We study a problem of detecting priming events based on a time series index and an evolving document stream. We define a priming event as an event which triggers abnormal movements of the time series index, i.e., the Iraq war with respect to the president approval index of President Bush. Existing solutions either focus on organizing coherent keywords from a document stream into events or identifying correlated movements between keyword frequency trajectories and the time series index. In this paper, we tackle the problem in two major steps. (1) We identify the elements that form a priming event. The element identified is called influential topic which consists of a set of coherent keywords. And we extract them by looking at the correlation between keyword trajectories and the interested time series index at a global level. (2) We extract priming events by detecting and organizing the bursty influential topics at a micro level. We evaluate our algorithms on a real-world dataset and the result confirms that ou...

  12. Sums of many primes

    CERN Document Server

    Languasco, Alessandro

    2011-01-01

    Assuming that the Generalized Riemann Hypothesis (GRH) holds, we prove an explicit formula for the number of representations of an integer as a sum of $k\\geq 5$ primes. Our error terms in such a formula improve by some logarithmic factors an analogous result by Friedlander-Goldston.

  13. PrimeFaces blueprints

    CERN Document Server

    Jonna, Sudheer

    2014-01-01

    If you are a Java developer with experience of frontend UI development, and want to take the plunge to develop stunning UI applications with the most popular JSF framework, PrimeFaces, then this book is for you. For those with entrepreneurial aspirations, this book will provide valuable insights into how to utilize successful business models.

  14. On Particles and Primes

    CERN Document Server

    Knill, Oliver

    2016-01-01

    Primes in the two complete associative normed division algebras C and H have affinities with structures seen in the standard model of particle physics. On the integers in the two algebras, there are two equivalence relations: a strong one, related to a U(1) and SU(3) symmetry allowing to permute and switch signs of the coordinates of the integers, as well as a weak relation with origins from units U(1),SU(2) in the algebra. Weak equivalence classes within the strong equivalence classes of odd primes in C case relate to leptons, the inert ones being neutrino like, and the split ones resembling electron-positron pairs. In the H case, for odd primes, the equivalence classes come in groups of two or three, leading to a caricature of hadrons featuring either mesons built by a quark pair or then baryons obtained by quark triplets. We can now list for every rational prime p all these particles and attach fractional charges to its constituents.

  15. Learning PrimeFaces extensions development

    CERN Document Server

    Jonna, Sudheer

    2014-01-01

    This book provides a step by step approach that explains the most important extension components and their features. All the major features are explained by using the JobHub application with supporting screenshots.If you are an intermediate to advanced level user (or developer) who already has a basic working knowledge of PrimeFaces, then this book is for you.The only thing you need to know is Java Server Faces(JSF).

  16. The priming of basic combinatory responses in MEG.

    Science.gov (United States)

    Blanco-Elorrieta, Esti; Ferreira, Victor S; Del Prato, Paul; Pylkkänen, Liina

    2017-09-21

    Priming has been a powerful tool for the study of human memory and especially the memory representations relevant for language. However, although it is well established that lexical access can be primed, we do not know exactly what types of computations can be primed above the word level. This work took a neurobiological approach and assessed the ways in which the complex representation of a minimal combinatory phrase, such as red boat, can be primed, as evidenced by the spatiotemporal profiles of magnetoencephalography (MEG) signals. Specifically, we built upon recent progress on the neural signatures of phrasal composition and tested whether the brain activities implicated for the basic combination of two words could be primed. In two experiments, MEG was recorded during a picture naming task where the prime trials were designed to replicate previously reported combinatory effects and the target trials to test whether those combinatory effects could be primed. The manipulation of the primes was successful in eliciting larger activity for adjective-noun combinations than single nouns in left anterior temporal and ventromedial prefrontal cortices, replicating prior MEG studies on parallel contrasts. Priming of similarly timed activity was observed during target trials in anterior temporal cortex, but only when the prime and target shared an adjective. No priming in temporal cortex was observed for single word repetition and two control tasks showed that the priming effect was not elicited if the prime pictures were simply viewed but not named. In sum, this work provides evidence that very basic combinatory operations can be primed, with the necessity for some lexical overlap between prime and target suggesting combinatory conceptual, as opposed to syntactic processing. Both our combinatory and priming effects were early, onsetting between 100 and 150ms after picture onset and thus are likely to reflect the very earliest planning stages of a combinatory message

  17. Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry.

    Science.gov (United States)

    Kim, Nam Ah; Jin, Jing Hui; Kim, Kyung-Hee; Lim, Dae Gon; Cheong, Heesun; Kim, Yun Hwan; Ju, Woong; Kim, Seung Cheol; Jeong, Seong Hoon

    2016-05-01

    Ovarian cancer is recognized with high mortality due to asymptomatic nature of the disease and difficulties in diagnosing early stage of the cancer. The present study evaluates the use of differential scanning calorimetry (DSC) in differentiating the severity of ovarian cancer from healthy women. 47 diseased women were subdivided into four stages with respect to clinical relevance and severity. Stages I-II were regarded as early stages and stages III-IV were regarded as advanced stages. The two average transition temperatures (T m ) increased with disease severity from 64.84 and 70.32 °C (healthy) to 68.46 and 75.24 °C (stage IV), respectively. T m were increased depending on clinical groups. In addition, the change in heat capacity was also dependent on the disease severity. To further support and investigate the nature of the proposed interactions, matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis is employed. The results suggest the differences in peptide expression between early and advanced stage of ovarian cancer, affected abundant proteins in plasma. The combined DSC and MS approach was supportive in identifying a unique signature of ovarian cancer stages, and demonstrates the potential of DSC as a complementary diagnostic tool in the evaluation of early stage ovarian cancer.

  18. Chen's Theorem with Small Primes

    Institute of Scientific and Technical Information of China (English)

    Ying Chun CAI

    2002-01-01

    Let N be a sufficiently large even integer. In this paper it is proved that the equationN = p + P2, p ≤ N0.95,is solvable, where p denotes a prime and P2 denotes an almost prime with at most two prime factors.

  19. Chen's Theorem with Small Primes

    Institute of Scientific and Technical Information of China (English)

    Yingjie LI; Yingchun CAI

    2011-01-01

    Let N be a sufficiently large even integer. Let p denote a prime and P2 denote an almost prime with at most two prime factors. In this paper, it is proved that the equation N - p+ P2 (p ≤ AT0.945) is solvable.

  20. Superficial Priming in Episodic Recognition

    Science.gov (United States)

    Dopkins, Stephen; Sargent, Jesse; Ngo, Catherine T.

    2010-01-01

    We explored the effect of superficial priming in episodic recognition and found it to be different from the effect of semantic priming in episodic recognition. Participants made recognition judgments to pairs of items, with each pair consisting of a prime item and a test item. Correct positive responses to the test item were impeded if the prime…

  1. Masked Repetition Priming Using Magnetoencephalography

    Science.gov (United States)

    Monahan, Philip J.; Fiorentino, Robert; Poeppel, David

    2008-01-01

    Masked priming is used in psycholinguistic studies to assess questions about lexical access and representation. We present two masked priming experiments using MEG. If the MEG signal elicited by words reflects specific aspects of lexical retrieval, then one expects to identify specific neural correlates of retrieval that are sensitive to priming.…

  2. Rhizosphere priming: a nutrient perspective

    Science.gov (United States)

    Rhizosphere priming is the change in decomposition of soil organic matter (SOM) caused by root activity. Rhizosphere priming plays a crucial role in soil carbon (C) dynamics and their response to global climate change. Rhizosphere priming may be affected by soil nutrient availability, but rhizospher...

  3. Cantor Primes as Prime-Valued Cyclotomic Polynomials

    CERN Document Server

    Salas, Christian

    2012-01-01

    Cantor primes are primes p such that 1/p belongs to the middle-third Cantor set. One way to look at them is as base-3 analogues of the famous Mersenne primes, which encompass all base-2 repunit primes, i.e., primes consisting of a contiguous sequence of 1's in base 2 and satisfying an equation of the form p + 1 = 2^q. The Cantor primes encompass all base-3 repunit primes satisfying an equation of the form 2p + 1 = 3^q, and I show that in general all Cantor primes > 3 satisfy a closely related equation of the form 2pK + 1 = 3^q, with the base-3 repunits being the special case K = 1. I use this to prove that the Cantor primes > 3 are exactly the prime-valued cyclotomic polynomials of the form $\\Phi_s(3^{s^j}) \\equiv 1$ (mod 4). Significant open problems concern the infinitude of these, making Cantor primes perhaps more interesting than previously realised.

  4. The Effect of Salt Priming on the Performance of Differentially Matured Cucumber (Cucumis sativus Seeds

    Directory of Open Access Journals (Sweden)

    Kazem GHASSEMI-GOLEZANI

    2008-08-01

    Full Text Available The influence of salt priming (3% KNO3 for 3 days and 1% NaCl for 2 days at 20 degree on germination, seedling emergence and seedling dry weight of two Iranian cucumber cultivars of Basmenj and Varamin harvested at 25, 35 and 45 days after anthesis (DAA was investigated in an unheated glasshouse. Seed germination and seedling emergence and growth were significantly affected by seed maturity and priming. Maximum advantage of priming seedling vigour was observed in seeds harvested at 25 DAA. Smaller effects of priming were also seen in the decreased mean germination and emergence times and increased seedling dry weight of seeds harvested at 35 and 45 DAA. Priming reduced percentage of seeds that germinated, but failed to emerge. In all cases, KNO3 priming was more effective than NaCl priming. Therefore, KNO3 priming can be used to improve cucumber seedling emergence and establishment, particularly in early spring sowings at low temperatures.

  5. Profiling of Altered Metabolomic States in Nicotiana tabacum Cells Induced by Priming Agents

    Science.gov (United States)

    Mhlongo, Msizi I.; Steenkamp, Paul A.; Piater, Lizelle A.; Madala, Ntakadzeni E.; Dubery, Ian A.

    2016-01-01

    Metabolomics has developed into a valuable tool for advancing our understanding of plant metabolism. Plant innate immune defenses can be activated and enhanced so that, subsequent to being pre-sensitized, plants are able to launch a stronger and faster defense response upon exposure to pathogenic microorganisms, a phenomenon known as priming. Here, three contrasting chemical activators, namely acibenzolar-S-methyl, azelaic acid and riboflavin, were used to induce a primed state in Nicotiana tabacum cells. Identified biomarkers were then compared to responses induced by three phytohormones—abscisic acid, methyljasmonate, and salicylic acid. Altered metabolomes were studied using a metabolite fingerprinting approach based on liquid chromatography and mass spectrometry. Multivariate data models indicated that these inducers cause time-dependent metabolic perturbations in the cultured cells and revealed biomarkers of which the levels are affected by these agents. A total of 34 metabolites were annotated from the mass spectral data and online databases. Venn diagrams were used to identify common biomarkers as well as those unique to a specific agent. Results implicate 20 cinnamic acid derivatives conjugated to (i) quinic acid (chlorogenic acids), (ii) tyramine, (iii) polyamines, or (iv) glucose as discriminatory biomarkers of priming in tobacco cells. Functional roles for most of these metabolites in plant defense responses could thus be proposed. Metabolites induced by the activators belong to the early phenylpropanoid pathway, which indicates that different stimuli can activate similar pathways but with different metabolite fingerprints. Possible linkages to phytohormone-dependent pathways at a metabolomic level were indicated in the case of cells treated with salicylic acid and methyljasmonate. The results contribute to a better understanding of the priming phenomenon and advance our knowledge of cinnamic acid derivatives as versatile defense metabolites. PMID

  6. Semantic priming of familiar songs.

    Science.gov (United States)

    Johnson, Sarah K; Halpern, Andrea R

    2012-05-01

    We explored the functional organization of semantic memory for music by comparing priming across familiar songs both within modalities (Experiment 1, tune to tune; Experiment 3, category label to lyrics) and across modalities (Experiment 2, category label to tune; Experiment 4, tune to lyrics). Participants judged whether or not the target tune or lyrics were real (akin to lexical decision tasks). We found significant priming, analogous to linguistic associative-priming effects, in reaction times for related primes as compared to unrelated primes, but primarily for within-modality comparisons. Reaction times to tunes (e.g., "Silent Night") were faster following related tunes ("Deck the Hall") than following unrelated tunes ("God Bless America"). However, a category label (e.g., Christmas) did not prime tunes from within that category. Lyrics were primed by a related category label, but not by a related tune. These results support the conceptual organization of music in semantic memory, but with potentially weaker associations across modalities.

  7. Subliminal Semantic Priming in Speech

    Science.gov (United States)

    Tillmann, Barbara; Perrin, Fabien

    2011-01-01

    Numerous studies have reported subliminal repetition and semantic priming in the visual modality. We transferred this paradigm to the auditory modality. Prime awareness was manipulated by a reduction of sound intensity level. Uncategorized prime words (according to a post-test) were followed by semantically related, unrelated, or repeated target words (presented without intensity reduction) and participants performed a lexical decision task (LDT). Participants with slower reaction times in the LDT showed semantic priming (faster reaction times for semantically related compared to unrelated targets) and negative repetition priming (slower reaction times for repeated compared to semantically related targets). This is the first report of semantic priming in the auditory modality without conscious categorization of the prime. PMID:21655277

  8. Subliminal semantic priming in speech.

    Directory of Open Access Journals (Sweden)

    Jérôme Daltrozzo

    Full Text Available Numerous studies have reported subliminal repetition and semantic priming in the visual modality. We transferred this paradigm to the auditory modality. Prime awareness was manipulated by a reduction of sound intensity level. Uncategorized prime words (according to a post-test were followed by semantically related, unrelated, or repeated target words (presented without intensity reduction and participants performed a lexical decision task (LDT. Participants with slower reaction times in the LDT showed semantic priming (faster reaction times for semantically related compared to unrelated targets and negative repetition priming (slower reaction times for repeated compared to semantically related targets. This is the first report of semantic priming in the auditory modality without conscious categorization of the prime.

  9. QuakeUp: An advanced tool for a network-based Earthquake Early Warning system

    Science.gov (United States)

    Zollo, Aldo; Colombelli, Simona; Caruso, Alessandro; Elia, Luca; Brondi, Piero; Emolo, Antonio; Festa, Gaetano; Martino, Claudio; Picozzi, Matteo

    2017-04-01

    The currently developed and operational Earthquake Early warning, regional systems ground on the assumption of a point-like earthquake source model and 1-D ground motion prediction equations to estimate the earthquake impact. Here we propose a new network-based method which allows for issuing an alert based upon the real-time mapping of the Potential Damage Zone (PDZ), e.g. the epicentral area where the peak ground velocity is expected to exceed the damaging or strong shaking levels with no assumption about the earthquake rupture extent and spatial variability of ground motion. The platform includes the most advanced techniques for a refined estimation of the main source parameters (earthquake location and magnitude) and for an accurate prediction of the expected ground shaking level. The new software platform (QuakeUp) is under development at the Seismological Laboratory (RISSC-Lab) of the Department of Physics at the University of Naples Federico II, in collaboration with the academic spin-off company RISS s.r.l., recently gemmated by the research group. The system processes the 3-component, real-time ground acceleration and velocity data streams at each station. The signal quality is preliminary assessed by checking the signal-to-noise ratio both in acceleration, velocity and displacement and through dedicated filtering algorithms. For stations providing high quality data, the characteristic P-wave period (τ_c) and the P-wave displacement, velocity and acceleration amplitudes (P_d, Pv and P_a) are jointly measured on a progressively expanded P-wave time window. The evolutionary measurements of the early P-wave amplitude and characteristic period at stations around the source allow to predict the geometry and extent of PDZ, but also of the lower shaking intensity regions at larger epicentral distances. This is done by correlating the measured P-wave amplitude with the Peak Ground Velocity (PGV) and Instrumental Intensity (I_MM) and by mapping the measured and

  10. Coastal glaciers advanced onto Jameson Land, East Greenland during the late glacial–early Holocene Milne Land Stade

    Directory of Open Access Journals (Sweden)

    Helena Alexanderson

    2014-01-01

    Full Text Available We report on 10Be and optically stimulated luminescence ages from moraines and glaciolacustrine sediments on eastern Jameson Land, East Greenland. Sampled landforms and sediment are associated with advances of outlet glaciers from the local Liverpool Land ice cap situated in the coastal Scoresby Sund region. Previous studies have tentatively correlated these advances with the Milne Land Stade moraines, which are prominent moraine sets deposited by mountain glaciers in the inner Scoresby Sund region. Recent constraints on the formation of the outer and inner of these moraines have suggested two advances of local glaciers, one prior to or during the Younger Dryas and another during the Preboreal. In this paper, we test the correlation of the Liverpool Land glacial advance with the Milne Land Stade. Our results show that outlet glaciers from the Liverpool Land ice cap reached ice-marginal positions marked by moraines in east-facing valleys on Jameson Land sometime during late glacial–early Holocene time (ca. 13–11 Kya. This confirms the correlation of these moraines with the Milne Land Stade moraines described elsewhere in the Scoresby Sund region.

  11. Reversible Motor Paralysis and Early Cardiac Rehabilitation in Patients With Advanced Heart Failure Receiving Left Ventricular Assist Device Therapy.

    Science.gov (United States)

    Amao, Rie; Imamura, Teruhiko; Nakahara, Yasuo; Noguchi, Satoko; Kinoshita, Osamu; Yamauchi, Haruo; Ono, Minoru; Haga, Nobuhiko

    2016-12-02

    Advanced heart failure (HF) is sometimes complicated with brain impairment because of a microthrombosis caused by decreased left ventricular contraction or reduced brain circulation. Some patients may recover after left ventricular assist device (LVAD) implantation. However, little is known about the perioperative therapeutic strategy in patients suffering from such complications, particularly from a cardiac rehabilitation viewpoint. We report on a 58-year-old male patient with a previous history of poliomyelitis and a light paralysis in the left upper extremity, who suffered left hemiplegia with no evidence of stroke after hemodynamic deterioration. The combination therapy of perioperative cardiac rehabilitation and LVAD therapy improved his left hemiplegia as well as activities of daily living, and the patient was discharged on foot on postoperative day 72 after briefing the family on LVAD home management. Early initiation of cardiac rehabilitation before LVAD implantation may be a key for the smooth discharge and resocialization of patients suffering from brain impairment complicated with advanced HF.

  12. A study to assess the feasibility of introducing early palliative care in ambulatory patients with advanced lung cancer

    Directory of Open Access Journals (Sweden)

    Jayita Kedar Deodhar

    2017-01-01

    Full Text Available Purpose: Early palliative care is beneficial in advanced lung cancer patients. We aimed to assess the feasibility of introducing early palliative care in ambulatory advanced lung cancer patients in an Indian tertiary cancer center. Methodology: In a longitudinal, single–arm, and single-center study, fifty patients were recruited and followed up every 3–4 weeks for 6 months, measuring the symptom burden using Edmonton Symptom Assessment Scale (ESAS and quality of life (QoL with European Organization for Research and Treatment of Cancer-QoL tools. The primary end point of feasibility was that at least 60% of the patients should complete 50% of the planned palliative care visits and over 50% of the patients should complete QoL questionnaires. Analysis was done using Statistical Package for the Social Sciences version 20. Results: Twenty-four of fifty patients (48% completed the planned follow-up visits. All patients completed the questionnaires at baseline and 31 (62% at their follow-up visits. The patients' main reasons for not following up in the hospital palliative care clinic were logistics and fatigue. Tiredness, pain, and appetite loss were the highest rated symptoms at baseline (ESAS scores 3, 2.2, and 2.1, respectively. Improvement in pain and anxiety scores at follow-up visits 1 and 2 was significant (P < 0.05. Scores on QoL functioning scales improved during the follow-up period. Conclusions: We did not meet the feasibility criteria for the introduction of early palliative care in our advanced lung cancer patients in a resource-limited country.

  13. Quantitation of oxidized triglyceride monomers and dimers as an useful measurement for early and advanced stages of oxidation

    Directory of Open Access Journals (Sweden)

    Márquez-Ruiz, G.

    1996-04-01

    Full Text Available Quantitation of oxidized triglyceride monomers and dimers is reported as a good measurement for early and advanced stages of oxidation. Applicability of this approach to follow-up oxidation was tested in samples of trilinolein and methyl linoleate stored at either room temperature or 60°C for different periods of time. Oxidized monomers, dimers and polymers were determined in 50 mg-samples by adding monostearin as internal standard and applying a combination of adsorption chromatography, using silica cartridges, followed by high-performance size-exclusion chromatography. Additionally, peroxide values and tocopherol contents were measured. Results showed that a significant rise of dimeric compounds denoted the end of the induction period while oxidized monomers were the only group of compounds showing a progressive increase during the early stages of oxidation.

  14. Supportive care in early rehabilitation for advanced-stage radiated head and neck cancer patients

    NARCIS (Netherlands)

    Leeuw, J.A.M. de; Berg, M.G. van den; Achterberg, T. van; Merkx, M.A.W.

    2013-01-01

    Objective To investigate the health-related quality of life (HRQoL) and supportive follow-up care needs 1 month posttreatment for patients with advanced-stage (stage III or IV) radiated head and neck cancer (HNC) who were treated with curative intent. Study Design An exploratory, descriptive analysi

  15. Early Experiences After Adopting a Quality Improvement Portfolio Into the Academic Advancement Process.

    Science.gov (United States)

    Sehgal, Niraj L; Neeman, Naama; King, Talmadge E

    2017-01-01

    Academic medical centers (AMCs) and their academic departments are increasingly assuming leadership in the education, science, and implementation of quality improvement (QI) and patient safety efforts. Fostering, recognizing, and promoting faculty leading these efforts is challenging using traditional academic metrics for advancement. The authors adapted a nationally developed QI portfolio, adopted it into their own department's advancement process in 2012, and tracked its utilization and impact over the first two years of implementation. Sixty-seven QI portfolios were submitted with 100% of faculty receiving their requested academic advancement. Women represented 60% of the submitted portfolios, while the Divisions of General Internal Medicine and Hospital Medicine accounted for 60% of the submissions. The remaining 40% were from faculty in 10 different specialty divisions. Faculty attitudes about the QI portfolio were overwhelmingly positive, with 83% agreeing that it "was an effective tool for helping to better recognize faculty contributions in QI work" and 85% agreeing that it "was an effective tool for elevating the importance of QI work in our department." The QI portfolio was one part of a broader effort to create opportunities to recognize and support faculty involved in improvement work. Further adapting the tool to ensure that it complements-rather than duplicates-other elements of the advancement process is critical for continued utilization by faculty. This will also drive desired dissemination to other departments locally and other AMCs nationally who are similarly committed to cultivating faculty career paths in systems improvement.

  16. Postural and Object-Oriented Experiences Advance Early Reaching, Object Exploration, and Means-End Behavior

    Science.gov (United States)

    Lobo, Michele A.; Galloway, James C.

    2008-01-01

    The effects of 3 weeks of social (control), postural, or object-oriented experiences on 9- to 21-week-old infants' (N = 42) reaching, exploration, and means-end behaviors were assessed. Coders recorded object contacts, mouthing, fingering, attention, and affect from video. Postural and object-oriented experiences advanced reaching, haptic…

  17. Influence of Temporal Expectations on Response Priming by Subliminal Faces

    Science.gov (United States)

    Guex, Raphael; Vuilleumier, Patrik

    2016-01-01

    Unconscious processes are often assumed immune from attention influence. Recent behavioral studies suggest however that the processing of subliminal information can be influenced by temporal attention. To examine the neural mechanisms underlying these effects, we used a stringent masking paradigm together with fMRI to investigate how temporal attention modulates the processing of unseen (masked) faces. Participants performed a gender decision task on a visible neutral target face, preceded by a masked prime face that could vary in gender (same or different than target) and emotion expression (neutral or fearful). We manipulated temporal attention by instructing participants to expect targets to appear either early or late during the stimulus sequence. Orienting temporal attention to subliminal primes influenced response priming by masked faces, even when gender was incongruent. In addition, gender-congruent primes facilitated responses regardless of attention while gender-incongruent primes reduced accuracy when attended. Emotion produced no differential effects. At the neural level, incongruent and temporally unexpected primes increased brain response in regions of the fronto-parietal attention network, reflecting greater recruitment of executive control and reorienting processes. Congruent and expected primes produced higher activations in fusiform cortex, presumably reflecting facilitation of perceptual processing. These results indicate that temporal attention can influence subliminal processing of face features, and thus facilitate information integration according to task-relevance regardless of conscious awareness. They also suggest that task-congruent information between prime and target may facilitate response priming even when temporal attention is not selectively oriented to the prime onset time. PMID:27764124

  18. Recruitment and Early Retention of Women with Advanced Breast Cancer in a Complementary and Alternative Medicine Trial

    Directory of Open Access Journals (Sweden)

    Alla Sikorskii

    2011-01-01

    Full Text Available More than 80% of women with breast cancer are now reported to be using complementary and alternative medicine (CAM therapies during conventional treatment. A randomized clinical trial (RCT of reflexology with late stage breast cancer patients serves as the data source for this article. The purposes were to investigate: (i reasons for refusal to participate in a RCT of reflexology; (ii the differences between those who completed the baseline interview and those who dropped out before baseline; and (iii the utility of the Palliative Prognostic Score (PPS as a prognostic screening tool in minimizing early attrition (before baseline from the trial. Eligible women (N = 400 approached at 12 cancer centers in the Midwest had advanced breast cancer, were on chemotherapy or hormonal therapy, and had a PPS of 11 or less. Comparisons of those who dropped out early (N = 33 to those who stayed in the trial (N = 240 were carried out using Wilcoxon rank, t-, chi-squared and Fisher's exact tests. The reasons of being “too sick” or “overwhelmed” were given by less than 12% of the women who refused to participate. There was a higher early dropout rate among black women compared to other (primarily white women (P = .01. Cancer recurrence and metastasis, age, and the PPS were not predictive of early retention of women. Specialized techniques may be needed to ensure black women remain in the trial once consented. Women with advanced disease were likely to enter and remain in the trial despite deterioration in health.

  19. Hyperspectral remote sensing for advanced detection of early blight (Alternaria solani) disease in potato (Solanum tuberosum) plants

    Science.gov (United States)

    Atherton, Daniel

    Early detection of disease and insect infestation within crops and precise application of pesticides can help reduce potential production losses, reduce environmental risk, and reduce the cost of farming. The goal of this study was the advanced detection of early blight (Alternaria solani) in potato (Solanum tuberosum) plants using hyperspectral remote sensing data captured with a handheld spectroradiometer. Hyperspectral reflectance spectra were captured 10 times over five weeks from plants grown to the vegetative and tuber bulking growth stages. The spectra were analyzed using principal component analysis (PCA), spectral change (ratio) analysis, partial least squares (PLS), cluster analysis, and vegetative indices. PCA successfully distinguished more heavily diseased plants from healthy and minimally diseased plants using two principal components. Spectral change (ratio) analysis provided wavelengths (490-510, 640, 665-670, 690, 740-750, and 935 nm) most sensitive to early blight infection followed by ANOVA results indicating a highly significant difference (p < 0.0001) between disease rating group means. In the majority of the experiments, comparisons of diseased plants with healthy plants using Fisher's LSD revealed more heavily diseased plants were significantly different from healthy plants. PLS analysis demonstrated the feasibility of detecting early blight infected plants, finding four optimal factors for raw spectra with the predictor variation explained ranging from 93.4% to 94.6% and the response variation explained ranging from 42.7% to 64.7%. Cluster analysis successfully distinguished healthy plants from all diseased plants except for the most mildly diseased plants, showing clustering analysis was an effective method for detection of early blight. Analysis of the reflectance spectra using the simple ratio (SR) and the normalized difference vegetative index (NDVI) was effective at differentiating all diseased plants from healthy plants, except for the

  20. Early

    Directory of Open Access Journals (Sweden)

    Kamel Abd Elaziz Mohamed

    2014-04-01

    Conclusion: Early PDT is recommended for patients who require prolonged tracheal intubation in the ICU as outcomes like the duration of mechanical ventilation length of ICU stay and hospital stay were significantly shorter in early tracheostomy.

  1. On the fractal distribution of primes and prime-indexed primes by the binary image analysis

    Science.gov (United States)

    Cattani, Carlo; Ciancio, Armando

    2016-10-01

    In this paper, the distribution of primes and prime-indexed primes (PIPs) is studied by mapping primes into a binary image which visualizes the distribution of primes. These images show that the distribution of primes (and PIPs) is similar to a Cantor dust, moreover the self-similarity with respect to the order of PIPs (already proven in Batchko (2014)) can be seen as an invariance of the binary images. The index of primes plays the same role of the scale for fractals, so that with respect to the index the distribution of prime-indexed primes is characterized by the self-similarity alike any other fractal. In particular, in order to single out the scale dependence, the PIPs fractal distribution will be evaluated by limiting to two parameters, fractal dimension (δ) and lacunarity (λ), that are usually used to measure the fractal nature. Because of the invariance of the corresponding binary plots, the fractal dimension and lacunarity of primes distribution are invariant with respect to the index of PIPs.

  2. Difference between consecutive primes

    Institute of Scientific and Technical Information of China (English)

    贾朝华

    1995-01-01

    Suppose that B is a sufficiently large positive constant, ε is a sufficiently small positive constant, X and N are sufficiently large. It is mainly proved that i) for the positive integers n, Xprime number; ii) if A = N1/2+s, then the even numbers in the interval (N, N+A), except for 0(Alog-B N) values, are all Goldbach numbers.

  3. Improving the Data Quality of Advanced LIGO Based on Early Engineering Run Results

    CERN Document Server

    Nuttall, L K; Areeda, J; Betzwieser, J; Dwyer, S; Effler, A; Fisher, R P; Fritschel, P; Kissel, J S; Lundgren, A P; Macleod, D M; Martynov, D; McIver, J; Mullavey, A; Sigg, D; Smith, J R; Vajente, G; Williamson, A R; Wipf, C C

    2015-01-01

    The Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors have completed their initial upgrade phase and will enter the first observing run in late 2015, with detector sensitivity expected to improve in future runs. Through the combined efforts of on-site commissioners and the Detector Characterization group of the LIGO Scientific Collaboration, interferometer performance, in terms of data quality, at both LIGO observatories has vastly improved from the start of commissioning efforts to present. Advanced LIGO has already surpassed Enhanced LIGO in sensitivity, and the rate of noise transients, which would negatively impact astrophysical searches, has improved. Here we give details of some of the work which has taken place to better the quality of the LIGO data ahead of the first observing run.

  4. Localization of generic gravitational-wave transients with the early advanced LIGO and Virgo detectors

    CERN Document Server

    Essick, Reed; Katsavounidis, Erik; Vedovato, Gabriele; Klimenko, Sergey

    2014-01-01

    The Laser Interferometer Gravitational wave Observatory (LIGO) and Virgo, advanced ground-based gravitational-wave detectors, will begin collecting science data in 2015. With first detections expected to follow, it is important to quantify how well generic gravitational-wave transients can be localized on the sky. This is crucial for correctly identifying electromagnetic counterparts as well as understanding gravitational-wave physics and source populations. We present a study of sky localization capabilities for two search and parameter estimation algorithms: coherent WaveBurst, a maximum likelihood algorithm operating in close to real-time, and LALInferenceBurst, a Markov chain Monte Carlo parameter estimation algorithm developed to recover generic transient signals with latency of a few hours. Furthermore, we focus on the first few years of the advanced detector era, when we expect to only have two (2015) and later three (2016) operational detectors, all below design sensitivity. These detector configurati...

  5. Early Childhood Bilingualism Leads to Advances in Executive Attention: Dissociating Culture and Language

    Science.gov (United States)

    Yang, Sujin; Yang, Hwajin; Lust, Barbara

    2011-01-01

    This study investigated whether early especially efficient utilization of executive functioning in young bilinguals would transcend potential cultural benefits. To dissociate potential cultural effects from bilingualism, four-year-old U.S. Korean-English bilingual children were compared to three monolingual groups--English and Korean monolinguals…

  6. Exploring Early Reading Instructional Strategies to Advance the Print Literacy Development of Adolescent SLIFE

    Science.gov (United States)

    Montero, M. Kristiina; Newmaster, Sharon; Ledger, Stephanie

    2014-01-01

    The research presented in this article examines the English language and print literacy development of adolescent refugee students with limited and interrupted formal education (SLIFE) aged 14 to 21. The aim of this research was to determine if and how teaching early reading strategies to secondary ESL/ELD teachers could improve students'…

  7. Transanal endoscopic microsurgery for advanced polyps and early cancers in the rectum-Long-term outcome

    DEFF Research Database (Denmark)

    Al-Najami, Issam; Rancinger, Carl Philip; Larsen, Morten Kobaek;

    2016-01-01

    Transanal endoscopic microsurgery (TEM) allows for the resection of large adenomas and early stage cancers in the rectum. The rate of complications and recurrence for malignant tumors compared with benign tumors has been questioned.The objective of our study was to analyze the outcome after TEM p...

  8. Onboarding Experiences: An Examination of Early Institutional Advancement Professionals' Decisions

    Science.gov (United States)

    Radosh, Meghan E.

    2013-01-01

    Onboarding is a new employee orientation process that is designed to formalize and socialize new hires to an organization, or in this case higher education institutions. The onboarding experience that many new employees have can shape employee views and first impressions of their new employer, and shape their early career path to stay or leave…

  9. Transanal endoscopic microsurgery for advanced polyps and early cancers in the rectum-Long-term outcome

    DEFF Research Database (Denmark)

    Al-Najami, Issam; Rancinger, Carl Philip; Larsen, Morten Kobaek

    2016-01-01

    Transanal endoscopic microsurgery (TEM) allows for the resection of large adenomas and early stage cancers in the rectum. The rate of complications and recurrence for malignant tumors compared with benign tumors has been questioned.The objective of our study was to analyze the outcome after TEM p...

  10. Psychotherapy Augmentation through Preconscious Priming

    OpenAIRE

    Borgeat, François; O’Connor, Kieron; Amado, Danielle; St-Pierre-Delorme, Marie-Ève

    2013-01-01

    Objective: To test the hypothesis that repeated preconscious (masked) priming of personalized positive cognitions could augment cognitive change and facilitate achievement of patients’ goals following a therapy. Methods: Twenty social phobic patients (13 women) completed a 36-weeks study beginning by 12 weeks of group behavioral therapy. After the therapy, they received 6 weeks of preconscious priming and 6 weeks of a control procedure in a randomized cross-over design. The Priming conditi...

  11. Early Student Support for Application of Advanced Multi-Core Processor Technologies to Oceanographic Research

    Science.gov (United States)

    2016-05-07

    vehicle changes that can impact a deployment. The following sections explore the current state-of-the- art research in the areas described above and how...Student Support for Appl ication of Advanced Multi-Core Processor N00014-12-1-0298 Technologies to Oceanographic Research Sb. GRANT NUMBER Sc...and configuration based on resource availability. When a device is discovered that has failed or isn’t performing as expected, it is removed from

  12. Transposed-Letter Priming Effects with Masked Subset Primes: A Re-Examination of the "Relative Position Priming Constraint"

    Science.gov (United States)

    Stinchcombe, Eric J.; Lupker, Stephen J.; Davis, Colin J.

    2012-01-01

    Three experiments are reported investigating the role of letter order in orthographic subset priming (e.g., "grdn"-GARDEN) using both the conventional masked priming technique as well as the sandwich priming technique in a lexical decision task. In all three experiments, subset primes produced priming with the effect being considerably…

  13. Transposed-Letter Priming Effects with Masked Subset Primes: A Re-Examination of the "Relative Position Priming Constraint"

    Science.gov (United States)

    Stinchcombe, Eric J.; Lupker, Stephen J.; Davis, Colin J.

    2012-01-01

    Three experiments are reported investigating the role of letter order in orthographic subset priming (e.g., "grdn"-GARDEN) using both the conventional masked priming technique as well as the sandwich priming technique in a lexical decision task. In all three experiments, subset primes produced priming with the effect being considerably…

  14. Bones, breasts, and bisphosphonates: rationale for the use of zoledronic acid in advanced and early breast cancer

    Directory of Open Access Journals (Sweden)

    Allan Lipton

    2011-03-01

    Full Text Available Allan LiptonMilton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, USAAbstract: Bisphosphonates inhibit osteoclast-mediated bone resorption, thereby inhibiting the release of growth factors necessary to promote cancer cell growth, differentiation, and tumor formation in bone. These agents have demonstrated efficacy for delaying the onset and reducing the incidence of skeletal-related events in the advanced breast cancer setting, and have been shown to prevent cancer therapy-induced bone loss in the early breast cancer setting. Emerging clinical data indicate that the role of bisphosphonates in advanced and early breast cancer is evolving. Retrospective analyses and recent clinical trial data show that zoledronic acid may improve outcomes in some patients with breast cancer. Data from ABCSG-12 and ZO-FAST suggest that zoledronic acid may improve disease-free survival in the adjuvant breast cancer setting in postmenopausal women or women with endocrine therapy-induced menopause, and recent data from a predefined subset of the AZURE trial added to the anticancer story. However, the overall negative AZURE trial also raises questions about the role of bisphosphonates as an anticancer agent in patients with breast cancer. Overall, these data suggest that the addition of zoledronic acid to established anticancer regimens may have potential anticancer benefits in specific patient populations, although more studies are required to define its role.Keywords: anticancer, adjuvant therapy, bone metastasis, skeletal, zoledronic acid

  15. Neuroimaging correlates of negative priming.

    Science.gov (United States)

    Steel, C; Haworth, E J; Peters, E; Hemsley, D R; Sharma, T; Gray, J A; Pickering, A; Gregory, L; Simmons, A; Bullmore, E T; Williams, S C

    2001-11-16

    Many theoretical accounts of selective attention and memory retrieval include reference to active inhibitory processes, such as those argued to underlie the negative priming effect. fMRI was used in order to investigate the areas of cortical activation associated with Stroop interference, Stroop facilitation and Stroop negative priming tasks. The most significant activation within the negative priming task was within the inferior parietal lobule, left temporal lobe and frontal lobes. Areas of cortical activation are discussed with reference to theoretical accounts of the negative priming effect.

  16. Seed priming: state of the art and new perspectives.

    Science.gov (United States)

    Paparella, S; Araújo, S S; Rossi, G; Wijayasinghe, M; Carbonera, D; Balestrazzi, Alma

    2015-08-01

    Priming applied to commercial seed lots is widely used by seed technologists to enhance seed vigour in terms of germination potential and increased stress tolerance. Priming can be also valuable to seed bank operators who need improved protocols of ex situ conservation of germplasm collections (crop and native species). Depending on plant species, seed morphology and physiology, different priming treatments can be applied, all of them triggering the so-called 'pre-germinative metabolism'. This physiological process takes place during early seed imbibition and includes the seed repair response (activation of DNA repair pathways and antioxidant mechanisms), essential to preserve genome integrity, ensuring proper germination and seedling development. The review provides an overview of priming technology, describing the range of physical-chemical and biological treatments currently available. Optimised priming protocols can be designed using the 'hydrotime concept' analysis which provides the theoretical bases for assessing the relationship between water potential and germination rate. Despite the efforts so far reported to further improve seed priming, novel ideas and cutting-edge investigations need to be brought into this technological sector of agri-seed industry. Multidisciplinary translational research combining digital, bioinformatic and molecular tools will significantly contribute to expand the range of priming applications to other relevant commercial sectors, e.g. the native seed market.

  17. Prime injections and quasipolarities

    Directory of Open Access Journals (Sweden)

    Octavio Alberto Agustín-Aquino

    2014-05-01

    Full Text Available Let $p$ be a prime number. Consider the injection\\[ \\iota:\\mathbb{Z}/n\\mathbb{Z}\\to\\mathbb{Z}/pn\\mathbb{Z}:x\\mapsto px, \\]and the elements $e^{u}.v:=(u,v\\in \\mathbb{Z}/n\\mathbb{Z}\\rtimes \\mathbb{Z}/n\\mathbb{Z}^{\\times}$ and$e^{w}.r:=(w,r\\in \\mathbb{Z}/pn \\mathbb{Z}\\rtimes \\mathbb{Z}/pn\\mathbb{Z}^{\\times}$. Suppose that $e^{u}.v\\in\\mathbb{Z}/n\\mathbb{Z}\\rtimes \\mathbb{Z}/n\\mathbb{Z}^{\\times}$ is seen as an automorphism of $\\mathbb{Z}/n\\mathbb{Z}$defined by $e^{u}.v(x=vx+u$; then $e^{u}.v$ is a \\emph{quasipolarity} if it is an involution without fixed points.In this brief note we give an explicit formula for the number of quasipolarities of $\\mathbb{Z}/n\\mathbb{Z}$ interms of the prime decomposition of $n$, and we prove sufficient conditions such that $(e^{w}.r\\circ \\iota=\\iota\\circ (e^{u}.v$, where $e^{w}.r$ and $e^{u}.v$ are quasipolarities.

  18. Investigating Home Primes and Their Families

    Science.gov (United States)

    Herman, Marlena; Schiffman, Jay

    2014-01-01

    The process of prime factor splicing to generate home primes raises opportunity for conjecture and exploration. The notion of "home primes" is relatively new in the chronicle of mathematics. Heleen (1996-97) first described a procedure called "prime factor splicing" (PFS). The exploration of home primes is interesting and…

  19. Primes, Geometry and Condensed Matter

    Directory of Open Access Journals (Sweden)

    Al Rabeh R. H.

    2009-07-01

    Full Text Available Fascination with primes dates back to the Greeks and before. Primes are named by some "the elementary particles of arithmetic" as every nonprime integer is made of a unique set of primes. In this article we point to new connections between primes, geometry and physics which show that primes could be called "the elementary particles of physics" too. This study considers the problem of closely packing similar circles/spheres in 2D/3D space. This is in effect a discretization process of space and the allowable number in a pack is found to lead to some unexpected cases of prime configurations which is independent of the size of the constituents. We next suggest that a non-prime can be considered geometrically as a symmetric collection that is separable (factorable into similar parts- six is two threes or three twos for example. A collection that has no such symmetry is a prime. As a result, a physical prime aggregate is more difficult to split symmetrically resulting in an inherent stability. This "number/physical" stability idea applies to bigger collections made from smaller (prime units leading to larger stable prime structures in a limitless scaling up process. The distribution of primes among numbers can be understood better using the packing ideas described here and we further suggest that differing numbers (and values of distinct prime factors making a nonprime collection is an important factor in determining the probability and method of possible and subsequent disintegration. Disintegration is bound by energy conservation and is closely related to symmetry by Noether theorems. Thinking of condensed matter as the packing of identical elements, we examine plots of the masses of chemical elements of the periodic table, and also those of the elementary particles of physics, and show that prime packing rules seem to play a role in the make up of matter. The plots show convincingly that the growth of prime numbers and that of the masses of

  20. Primes, Geometry and Condensed Matter

    Directory of Open Access Journals (Sweden)

    Al Rabeh R. H.

    2009-07-01

    Full Text Available Fascination with primes dates back to the Greeks and before. Primes are named by some “the elementary particles of arithmetic” as every nonprime integer is made of a unique set of primes. In this article we point to new connections between primes, geometry and physics which show that primes could be called “the elementary particles of physics” too. This study considers the problem of closely packing similar circles / spheres in 2D / 3D space. This is in effect a discretization process of space and the allowable num- ber in a pack is found to lead to some unexpected cases of prime configurations which is independent of the size of the constituents. We next suggest that a non-prime can be considered geometrically as a symmetric collection that is separable (factorable into similar parts- six is two threes or three twos for example. A collection that has no such symmetry is a prime. As a result, a physical prime aggregate is more difficult to split symmetrically resulting in an inherent stability. This “number / physical” stability idea applies to bigger collections made from smaller (prime units leading to larger sta- ble prime structures in a limitless scaling up process. The distribution of primes among numbers can be understood better using the packing ideas described here and we further suggest that differing numbers (and values of distinct prime factors making a nonprime collection is an important factor in determining the probability and method of possible and subsequent disintegration. Disintegration is bound by energy conservation and is closely related to symmetry by Noether theorems. Thinking of condensed matter as the packing of identical elements, we examine plots of the masses of chemical elements of the periodic table, and also those of the elementary particles of physics, and show that prime packing rules seem to play a role in the make up of matter. The plots show con- vincingly that the growth of prime numbers and that

  1. Priming the Secure Attachment Schema: Effects on Emotion Information Processing

    Directory of Open Access Journals (Sweden)

    Panoraia Andriopoulos

    2015-04-01

    Full Text Available The present study examined the effects of secure schema activation on selective attention towards attachment-related and emotional information. Seventy two participants were randomly allocated into two conditions–subliminal priming of mental representations of supportive attachment figures (a Picasso sketch of a mother holding a baby and looking into his eyes and a no priming condition followed by an administration of a dot probe task that included positive and negative attachment-related and emotion words. The results showed that the activation of the secure prime in conjunction with chronic attachment orientations affected the processing of positive and negative attachment-unrelated emotional information. Results highlight relationships between higher-order processes of the attachment system (attachment schema activation with early stage information processing (selective attention as assessed by the dot probe task. Methodological issues are discussed with reference to the priming method used and the traditional version of the dot-probe task.

  2. Helicobacter pylori infection is an independent risk factor of early and advanced colorectal neoplasm.

    Science.gov (United States)

    Kim, Tae Jun; Kim, Eun Ran; Chang, Dong Kyung; Kim, Young-Ho; Baek, Sun-Young; Kim, Kyunga; Hong, Sung Noh

    2017-06-01

    The role of Helicobacter pylori (H. pylori) in the development of colorectal neoplasm remains controversial. We examined the association between H. pylori infection and colorectal neoplasm in a large sample of healthy participants who underwent screening colonoscopy. A cross-sectional study of 8916 men, who participated in a regular health-screening examination that included an H. pylori-specific immunoglobulin G antibody test and colonoscopy, was conducted to evaluate the association between H. pylori and colorectal neoplasm. Multivariable analyses adjusted for age, body mass index, smoking status, alcohol intake, regular exercise, regular aspirin use, and family history of colorectal cancer showed that the odds ratio (OR) (95% confidence interval [CI]) for any adenoma and advanced neoplasm was 1.32 (1.07-1.61) and 1.90 (1.05-3.56) in participants with H. pylori infection and without H. pylori infection, respectively. The association persisted after further adjustment for inflammatory markers or metabolic variables including fasting blood glucose, triglycerides, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol. Regarding the location, a positive association was confined to cases with proximal adenomas and was observed similarly in all the evaluated subgroups. In a large-scale study, carefully controlled for confounding factors, involving asymptomatic participants without a history of colonoscopy, H. pylori infection was significantly associated with the risk of any colorectal adenoma and advanced colorectal neoplasm. Prospective studies are necessary to determine whether H. pylori eradication can reduce this risk. © 2017 John Wiley & Sons Ltd.

  3. Almost primes in short intervals

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this paper,we prove that the short interval(x-x101/232,x] contains at least an almost prime P2 for sufficiently large x,where P2 denotes an integer having at most two prime factors counted with multiplicity.

  4. Immediate Priming and Cognitive Aftereffects

    Science.gov (United States)

    Huber, David E.

    2008-01-01

    Three forced-choice perceptual word identification experiments tested the claim that transitions from positive to negative priming as a function of increasing prime duration are due to cognitive aftereffects. These aftereffects are similar in nature to perceptual aftereffects that produce a negative image due to overexposure and habituation to a…

  5. PrimeFaces beginner's guide

    CERN Document Server

    Reddy, K Siva Prasad

    2013-01-01

    A guide for beginner's with step-by-step instructions and an easy-to-follow approach.PrimeFaces Beginners Guide is a simple and effective guide for beginners, wanting to learn and implement PrimeFaces in their JSF-based applications. Some basic JSF and jQuery skills are required before you start working through the book.

  6. Repetition priming from moving faces.

    Science.gov (United States)

    Lander, Karen; Bruce, Vicki

    2004-06-01

    Recent experiments have suggested that seeing a familiar face move provides additional dynamic information to the viewer, useful in the recognition of identity. In four experiments, repetition priming was used to investigate whether dynamic information is intrinsic to the underlying face representations. The results suggest that a moving image primes more effectively than a static image, even when the same static image is shown in the prime and the test phases (Experiment 1). Furthermore, when moving images are presented in the test phase (Experiment 2), there is an advantage for moving prime images. The most priming advantage is found with naturally moving faces, rather than with those shown in slow motion (Experiment 3). Finally, showing the same moving sequence at prime and test produced more priming than that found when different moving sequences were shown (Experiment 4). The results suggest that dynamic information is intrinsic to the face representations and that there is an advantage to viewing the same moving sequence at prime and test.

  7. Rhizosphere priming: a nutrient perspective.

    Science.gov (United States)

    Dijkstra, Feike A; Carrillo, Yolima; Pendall, Elise; Morgan, Jack A

    2013-01-01

    Rhizosphere priming is the change in decomposition of soil organic matter (SOM) caused by root activity. Rhizosphere priming plays a crucial role in soil carbon (C) dynamics and their response to global climate change. Rhizosphere priming may be affected by soil nutrient availability, but rhizosphere priming itself can also affect nutrient supply to plants. These interactive effects may be of particular relevance in understanding the sustained increase in plant growth and nutrient supply in response to a rise in atmospheric CO2 concentration. We examined how these interactions were affected by elevated CO2 in two similar semiarid grassland field studies. We found that an increase in rhizosphere priming enhanced the release of nitrogen (N) through decomposition of a larger fraction of SOM in one study, but not in the other. We postulate that rhizosphere priming may enhance N supply to plants in systems that are N limited, but that rhizosphere priming may not occur in systems that are phosphorus (P) limited. Under P limitation, rhizodeposition may be used for mobilization of P, rather than for decomposition of SOM. Therefore, with increasing atmospheric CO2 concentrations, rhizosphere priming may play a larger role in affecting C sequestration in N poor than in P poor soils.

  8. Rhizosphere priming: a nutrient perspective

    Directory of Open Access Journals (Sweden)

    Feike Auke Dijkstra

    2013-07-01

    Full Text Available Rhizosphere priming is the change in decomposition of soil organic matter (SOM caused by root activity. Rhizosphere priming plays a crucial role in soil carbon (C dynamics and their response to global climate change. Rhizosphere priming may be affected by soil nutrient availability, but rhizosphere priming itself can also affect nutrient supply to plants. These interactive effects may be of particular relevance in understanding the sustained increase in plant growth and nutrient supply in response to a rise in atmospheric CO2 concentration. We examined how these interactions were affected by elevated CO2 in two similar semiarid grassland field studies. We found that an increase in rhizosphere priming enhanced the release of nitrogen (N through decomposition of a larger fraction of SOM in one study, but not in the other. We postulate that rhizosphere priming may enhance N supply to plants in systems that are N limited, but that rhizosphere priming may not occur in systems that are phosphorus (P limited. Under P limitation, rhizodeposition may be used for mobilisation of P, rather than for decomposition of SOM. Therefore, with increasing atmospheric CO2 concentrations, rhizosphere priming may play a larger role in affecting C sequestration in N poor than in P poor soils.

  9. Priming Macho Attitudes and Emotions.

    Science.gov (United States)

    Beaver, Erik D.; And Others

    1992-01-01

    Investigated the effects of reading one of four priming stimuli stories (control, consenting sex, rape, or family) on males' evaluations of, and emotional reactions to, two videotaped date-rape scenarios. Results supported the concepts of a macho personality and revealed interactive effects for both the rape and family prime. (RJM)

  10. Attentional priming releases crowding.

    Science.gov (United States)

    Kristjánsson, Arni; Heimisson, Pétur Rúnar; Róbertsson, Gunnar Freyr; Whitney, David

    2013-10-01

    Views of natural scenes unfold over time, and objects of interest that were present a moment ago tend to remain present. While visual crowding places a fundamental limit on object recognition in cluttered scenes, most studies of crowding have suffered from the limitation that they typically involved static scenes. The role of temporal continuity in crowding has therefore been unaddressed. We investigated intertrial effects upon crowding in visual scenes, showing that crowding is considerably diminished when objects remain constant on consecutive visual search trials. Repetition of both the target and distractors decreases the critical distance for crowding from flankers. More generally, our results show how object continuity through between-trial priming releases objects that would otherwise be unidentifiable due to crowding. Crowding, although it is a significant bottleneck on object recognition, can be mitigated by statistically likely temporal continuity of the objects. Crowding therefore depends not only on what is momentarily present, but also on what was previously attended.

  11. Exodus: Prime Mover

    Science.gov (United States)

    Bauer, Nikkol; Conwell, Pete; Johnson, Matt; Shields, Wendy; Thornton, Tim; Tokarz, Rob; Mcmanus, Rich

    1992-01-01

    The Exodus Prime Mover is an overnight package delivery aircraft designed to serve the Northern Hemisphere of Aeroworld. The preliminary design goals originated from the desire to produce a large profit. The two main driving forces throughout the design process were first to reduce the construction man-hours by simplifying the aircraft design, thereby decreasing the total production cost of the aircraft. The second influential factor affecting the design was minimizing the fuel cost during cruise. The lowest fuel consumption occurs at a cruise velocity of 30 ft/s. Overall, it was necessary to balance the economic benefits with the performance characteristics in order to create a profitable product that meets all specified requirements and objectives.

  12. The processing of consonants and vowels in reading: evidence from the fast priming paradigm.

    Science.gov (United States)

    Lee, Hye-Won; Rayner, Keith; Pollatsek, Alexander

    2002-12-01

    We assessed the early encoding of consonant and vowel information in the reading of English, using the fast priming paradigm. With 30-msec prime durations, gaze durations on target words were shorter when preceded by high-frequency consonant-same primes (which shared consonant information with the target word; e.g., lake-like) than when preceded by vowel-same primes (which shared vowel information with the target word; e.g., line-like), but there were no priming effects for low-frequency primes. With 45-msec prime durations, however, there was no effect of prime frequency and gaze durations on target words were shortened equally when they were preceded by consonant-same primes and vowel-same primes, as compared with control primes (e.g., late-like). The results suggest that the processing of consonants is more rapid than that of vowels, providing further evidence for the distinction between consonant and vowel processing in the reading of English.

  13. Priming semantico e museografia / Semantic priming and museography

    Directory of Open Access Journals (Sweden)

    Annalisa Banzi

    2012-05-01

    Full Text Available Il priming è una tipologia di memoria implicita che facilita l’apprendimento di stimoli di diversa natura (stimoli visivi, semantici, etc.. Un allestimento museale che adotti strumenti basati sul priming potrebbe aiutare il pubblico a selezionare i contenuti relativi agli oggetti esposti. In questo articolo viene descritta l’applicazione del priming semantico allo spazio museale. Questa operazione in prima battutta potrebbe essere letta come una mancanza di fiducia nelle capacità cognitive del visitatore nel discriminare il significato delle informazioni. In realtà è una forma di sostegno per aiutare il visitatore a sviluppare gradualmente una propria metodologia di approccio ai contenuti proposti nel museo. Grazie al priming, il pubblico riceve una serie di stimoli che possono aiutare a costituire la base delle proprie conoscenze in ambito storico-artistico ed essere il punto di partenza sul quale costruire un metodo critico.   Many psychological aspects such as motivation, emotion, and attention, affect human learning. Among these, priming triggers and tunes implicit memory processes. Hence the goal of this paper is to check whether semantic priming can be used as an effective tool to design a supportive museum environment where people can easily learn. Moreover, the resulting stronger and more persistent memories could encourage museum visitors to learn more and better, and to develop a method to “read” the artworks. After a brief overview of current models of semantic priming, practical and theoretical issues are considered and discussed.

  14. Advanced fiber tracking in early acquired brain injury causing cerebral palsy.

    Science.gov (United States)

    Lennartsson, F; Holmström, L; Eliasson, A-C; Flodmark, O; Forssberg, H; Tournier, J-D; Vollmer, B

    2015-01-01

    Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group. This cross-sectional study included 17 children with unilateral cerebral palsy and 24 typically developing controls. DWI data were collected at 1.5T (45 directions, b=1000 s/mm(2)). Regions of interest were defined on a study-specific fractional anisotropy template and mapped onto subjects for fiber tracking. Probabilistic fiber tracking of the corticospinal tract and thalamic projections to the somatosensory cortex was performed by using constrained spherical deconvolution. Tracts were qualitatively assessed, and DTI parameters were extracted close to and distant from lesions and compared between groups. The corticospinal tract and thalamic projections to the somatosensory cortex were realistically reconstructed in both groups. Structural changes to tracts were seen in the cerebral palsy group and included splits, dislocations, compaction of the tracts, or failure to delineate the tract and were associated with underlying pathology seen on conventional MR imaging. Comparisons of DTI parameters indicated primary and secondary neurodegeneration along the corticospinal tract. Corticospinal tract and thalamic projections to the somatosensory cortex showed dissimilarities in both structural changes and DTI parameters. Our proposed method offers a sensitive means to explore alterations in WM tracts to further understand pathophysiologic changes following early acquired brain injury. © 2015 by American Journal of Neuroradiology.

  15. Association of Early Patient-Physician Care Planning Discussions and End-of-Life Care Intensity in Advanced Cancer

    Science.gov (United States)

    Tisnado, Diana M.; Walling, Anne M.; Dy, Sydney M.; Asch, Steven M.; Ettner, Susan L.; Kim, Benjamin; Pantoja, Philip; Schreibeis-Baum, Hannah C.; Lorenz, Karl A.

    2015-01-01

    Abstract Background: Early patient-physician care planning discussions may influence the intensity of end-of-life (EOL) care received by veterans with advanced cancer. Objective: The study objective was to evaluate the association between medical record documentation of patient-physician care planning discussions and intensity of EOL care among veterans with advanced cancer. Methods: This was a retrospective cohort study. Subjects were 665 veteran decedents diagnosed with stage IV colorectal, lung, or pancreatic cancer in 2008, and followed till death or the end of the study period in 2011. We estimated the effect of patient-physician care planning discussions documented within one month of metastatic diagnosis on the intensity of EOL care measured by receipt of acute care, intensive interventions, chemotherapy, and hospice care, using multivariate logistic regression models. Results: Veterans in our study were predominantly male (97.1%), white (74.7%), with an average age at diagnosis of 66.4 years. Approximately 31% received some acute care, 9.3% received some intensive intervention, and 6.5% had a new chemotherapy regimen initiated in the last month of life. Approximately 41% of decedents received no hospice or were admitted within three days of death. Almost half (46.8%) had documentation of a care planning discussion within the first month after diagnosis and those who did were significantly less likely to receive acute care at EOL (OR: 0.67; p=0.025). Documented discussions were not significantly associated with intensive interventions, chemotherapy, or hospice care. Conclusion: Early care planning discussions are associated with lower rates of acute care use at the EOL in a system with already low rates of intensive EOL care. PMID:26186553

  16. Early Results from the Advanced Radiation Protection Thick GCR Shielding Project

    Science.gov (United States)

    Norman, Ryan B.; Clowdsley, Martha; Slaba, Tony; Heilbronn, Lawrence; Zeitlin, Cary; Kenny, Sean; Crespo, Luis; Giesy, Daniel; Warner, James; McGirl, Natalie; hide

    2017-01-01

    The Advanced Radiation Protection Thick Galactic Cosmic Ray (GCR) Shielding Project leverages experimental and modeling approaches to validate a predicted minimum in the radiation exposure versus shielding depth curve. Preliminary results of space radiation models indicate that a minimum in the dose equivalent versus aluminum shielding thickness may exist in the 20-30 g/cm2 region. For greater shield thickness, dose equivalent increases due to secondary neutron and light particle production. This result goes against the long held belief in the space radiation shielding community that increasing shielding thickness will decrease risk to crew health. A comprehensive modeling effort was undertaken to verify the preliminary modeling results using multiple Monte Carlo and deterministic space radiation transport codes. These results verified the preliminary findings of a minimum and helped drive the design of the experimental component of the project. In first-of-their-kind experiments performed at the NASA Space Radiation Laboratory, neutrons and light ions were measured between large thicknesses of aluminum shielding. Both an upstream and a downstream shield were incorporated into the experiment to represent the radiation environment inside a spacecraft. These measurements are used to validate the Monte Carlo codes and derive uncertainty distributions for exposure estimates behind thick shielding similar to that provided by spacecraft on a Mars mission. Preliminary results for all aspects of the project will be presented.

  17. Advanced Imaging for the Early Diagnosis of Local Recurrence Prostate Cancer after Radical Prostatectomy

    Directory of Open Access Journals (Sweden)

    Valeria Panebianco

    2014-01-01

    Full Text Available Currently the diagnosis of local recurrence of prostate cancer (PCa after radical prostatectomy (RT is based on the onset of biochemical failure which is defined by two consecutive values of prostate-specific antigen (PSA higher than 0.2 ng/mL. The aim of this paper was to review the current roles of advanced imaging in the detection of locoregional recurrence. A nonsystematic literature search using the Medline and Cochrane Library databases was performed up to November 2013. Bibliographies of retrieved and review articles were also examined. Only those articles reporting complete data with clinical relevance for the present review were selected. This review article is divided into two major parts: the first one considers the role of PET/CT in the restaging of PCa after RP; the second part is intended to provide the impact of multiparametric-MRI (mp-MRI in the depiction of locoregional recurrence. Published data indicate an emerging role for mp-MRI in the depiction of locoregional recurrence, while the performance of PET/CT still remains unclear. Moreover Mp-MRI, thanks to functional techniques, allows to distinguish between residual glandular healthy tissue, scar/fibrotic tissue, granulation tissue, and tumour recurrence and it may also be able to assess the aggressiveness of nodule recurrence.

  18. Advanced imaging for the early diagnosis of local recurrence prostate cancer after radical prostatectomy.

    Science.gov (United States)

    Panebianco, Valeria; Barchetti, Flavio; Musio, Daniela; De Felice, Francesca; Proietti, Camilla; Indino, Elena Lucia; Megna, Valentina; Schillaci, Orazio; Catalano, Carlo; Tombolini, Vincenzo

    2014-01-01

    Currently the diagnosis of local recurrence of prostate cancer (PCa) after radical prostatectomy (RT) is based on the onset of biochemical failure which is defined by two consecutive values of prostate-specific antigen (PSA) higher than 0.2 ng/mL. The aim of this paper was to review the current roles of advanced imaging in the detection of locoregional recurrence. A nonsystematic literature search using the Medline and Cochrane Library databases was performed up to November 2013. Bibliographies of retrieved and review articles were also examined. Only those articles reporting complete data with clinical relevance for the present review were selected. This review article is divided into two major parts: the first one considers the role of PET/CT in the restaging of PCa after RP; the second part is intended to provide the impact of multiparametric-MRI (mp-MRI) in the depiction of locoregional recurrence. Published data indicate an emerging role for mp-MRI in the depiction of locoregional recurrence, while the performance of PET/CT still remains unclear. Moreover Mp-MRI, thanks to functional techniques, allows to distinguish between residual glandular healthy tissue, scar/fibrotic tissue, granulation tissue, and tumour recurrence and it may also be able to assess the aggressiveness of nodule recurrence.

  19. Advanced Imaging and Receipt of Guideline Concordant Care in Women with Early Stage Breast Cancer

    Directory of Open Access Journals (Sweden)

    Elizabeth Trice Loggers

    2016-01-01

    Full Text Available Objective. It is unknown whether advanced imaging (AI is associated with higher quality breast cancer (BC care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washington State. We examined receipt of preoperative breast magnetic resonance imaging (MRI or AI (defined as computed tomography [CT]/positron emission tomography [PET]/PET/CT versus mammogram and/or ultrasound (M-US alone and receipt of guideline concordant care (GCC using multivariable logistic regression. Results. Of 5247 women, 67% received M-US, 23% MRI, 8% CT, and 3% PET/PET-CT. In 2002, 5% received MRI and 5% AI compared to 45% and 12%, respectively, in 2008. 79% received GCC, but GCC declined over time and was associated with younger age, urban residence, less comorbidity, shorter time from diagnosis to surgery, and earlier year of diagnosis. Breast MRI was associated with GCC for lumpectomy plus radiation therapy (RT (OR 1.55, 95% CI 1.08–2.26, and p=0.02 and AI was associated with GCC for adjuvant chemotherapy for estrogen-receptor positive (ER+ BC (OR 1.74, 95% CI 1.17–2.59, and p=0.01. Conclusion. GCC was associated with prior receipt of breast MRI and AI for lumpectomy plus RT and adjuvant chemotherapy for ER+ BC, respectively.

  20. Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study

    Directory of Open Access Journals (Sweden)

    Fouad Mona N

    2011-08-01

    Full Text Available Abstract Background We describe early dissemination patterns for first-line bevacizumab given for metastatic colorectal cancer treatment. Methods We analyzed patient surveys and medical records for a population-based cohort with metastatic colorectal cancer treated in multiple regions and health systems in the United States (US. Eligible patients were diagnosed with metastatic colorectal cancer and initiated first-line chemotherapy after US Food & Drug Administration (FDA bevacizumab approval in February 2004. First-line bevacizumab therapy was defined as receiving bevacizumab within 8 weeks of starting chemotherapy for metastatic colorectal cancer. We evaluated factors associated with first-line bevacizumab treatment using logistic regression. Results Among 355 patients, 31% received first-line bevacizumab in the two years after FDA approval, including 26% of men, 41% of women, and 16% of those ≥ 75 years. Use rose sharply within 6 months after FDA approval, then plateaued. 20% of patients received bevacizumab in combination with irinotecan; 53% received it with oxaliplatin. Men were less likely than women to receive bevacizumab (adjusted OR 0.55; 95% CI 0.32-0.93; p = 0.026. Patients ≥ 75 years were less likely to receive bevacizumab than patients Conclusions One-third of eligible metastatic colorectal cancer patients received first-line bevacizumab shortly after FDA approval. Most patients did not receive bevacizumab as part of the regimen used in the pivotal study leading to FDA approval.

  1. Modeling the Interaction between Quinolinate and the Receptor for Advanced Glycation End Products (RAGE): Relevance for Early Neuropathological Processes

    Science.gov (United States)

    Serratos, Iris N.; Castellanos, Pilar; Pastor, Nina; Millán-Pacheco, César; Rembao, Daniel; Pérez-Montfort, Ruy; Cabrera, Nallely; Reyes-Espinosa, Francisco; Díaz-Garrido, Paulina; López-Macay, Ambar; Martínez-Flores, Karina; López-Reyes, Alberto; Sánchez-García, Aurora; Cuevas, Elvis; Santamaria, Abel

    2015-01-01

    The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN)-induced toxicity. We investigated the QUIN-induced toxic events associated with early noxious responses, which might be linked to signaling cascades leading to cell death. The extent of early cellular damage caused by this receptor in the rat striatum was characterized by image processing methods. To document the direct interaction between QUIN and RAGE, we determined the binding constant (Kb) of RAGE (VC1 domain) with QUIN through a fluorescence assay. We modeled possible binding sites of QUIN to the VC1 domain for both rat and human RAGE. QUIN was found to bind at multiple sites to the VC1 dimer, each leading to particular mechanistic scenarios for the signaling evoked by QUIN binding, some of which directly alter RAGE oligomerization. This work contributes to the understanding of the phenomenon of RAGE-QUIN recognition, leading to the modulation of RAGE function. PMID:25757085

  2. Modeling the interaction between quinolinate and the receptor for advanced glycation end products (RAGE: relevance for early neuropathological processes.

    Directory of Open Access Journals (Sweden)

    Iris N Serratos

    Full Text Available The receptor for advanced glycation end products (RAGE is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN-induced toxicity. We investigated the QUIN-induced toxic events associated with early noxious responses, which might be linked to signaling cascades leading to cell death. The extent of early cellular damage caused by this receptor in the rat striatum was characterized by image processing methods. To document the direct interaction between QUIN and RAGE, we determined the binding constant (Kb of RAGE (VC1 domain with QUIN through a fluorescence assay. We modeled possible binding sites of QUIN to the VC1 domain for both rat and human RAGE. QUIN was found to bind at multiple sites to the VC1 dimer, each leading to particular mechanistic scenarios for the signaling evoked by QUIN binding, some of which directly alter RAGE oligomerization. This work contributes to the understanding of the phenomenon of RAGE-QUIN recognition, leading to the modulation of RAGE function.

  3. One World, Two Languages: Cross-Language Semantic Priming in Bilingual Toddlers

    Science.gov (United States)

    Singh, Leher

    2014-01-01

    The interconnectedness of bilingual memory remains a topic of great debate. Semantic priming provides a powerful methodological tool with which to investigate this issue in early bilingual toddlers. Semantic priming effects were investigated in 21 bilingual toddlers (2.5 years) within and across each of their languages. Results revealed the first…

  4. Optical coding theory with Prime

    CERN Document Server

    Kwong, Wing C

    2013-01-01

    Although several books cover the coding theory of wireless communications and the hardware technologies and coding techniques of optical CDMA, no book has been specifically dedicated to optical coding theory-until now. Written by renowned authorities in the field, Optical Coding Theory with Prime gathers together in one volume the fundamentals and developments of optical coding theory, with a focus on families of prime codes, supplemented with several families of non-prime codes. The book also explores potential applications to coding-based optical systems and networks. Learn How to Construct

  5. The Early Detection of the Emerald Ash Borer (EAB) Using Advanced Geospacial Technologies

    Science.gov (United States)

    Hu, B.; Li, J.; Wang, J.; Hall, B.

    2014-11-01

    The objectives of this study were to exploit Light Detection And Ranging (LiDAR) and very high spatial resolution (VHR) data and their synergy with hyperspectral imagery in the early detection of the EAB presence in trees within urban areas and to develop a framework to combine information extracted from multiple data sources. To achieve these, an object-oriented framework was developed to combine information derived from available data sets to characterize ash trees. Within this framework, individual trees were first extracted and then classified into different species based on their spectral information derived from hyperspectral imagery, spatial information from VHR imagery, and for each ash tree its health state and EAB infestation stage were determined based on hyperspectral imagery. The developed framework and methods were demonstrated to be effective according to the results obtained on two study sites in the city of Toronto, Ontario Canada. The individual tree delineation method provided satisfactory results with an overall accuracy of 78 % and 19 % commission and 23 % omission errors when used on the combined very high-spatial resolution imagery and LiDAR data. In terms of the identification of ash trees, given sufficient representative training data, our classification model was able to predict tree species with above 75 % overall accuracy, and mis-classification occurred mainly between ash and maple trees. The hypothesis that a strong correlation exists between general tree stress and EAB infestation was confirmed. Vegetation indices sensitive to leaf chlorophyll content derived from hyperspectral imagery can be used to predict the EAB infestation levels for each ash tree.

  6. Early Toxicity in Patients Treated With Postoperative Proton Therapy for Locally Advanced Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Cuaron, John J. [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Chon, Brian; Tsai, Henry; Goenka, Anuj; DeBlois, David [Procure Proton Therapy Center, Somerset, New Jersey (United States); Ho, Alice; Powell, Simon [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Hug, Eugen [Procure Proton Therapy Center, Somerset, New Jersey (United States); Cahlon, Oren, E-mail: cahlono@mskcc.org [Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Procure Proton Therapy Center, Somerset, New Jersey (United States)

    2015-06-01

    Purpose: To report dosimetry and early toxicity data in breast cancer patients treated with postoperative proton radiation therapy. Methods and Materials: From March 2013 to April 2014, 30 patients with nonmetastatic breast cancer and no history of prior radiation were treated with proton therapy at a single proton center. Patient characteristics and dosimetry were obtained through chart review. Patients were seen weekly while on treatment, at 1 month after radiation therapy completion, and at 3- to 6-month intervals thereafter. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4.0. Frequencies of toxicities were tabulated. Results: Median dose delivered was 50.4 Gy (relative biological equivalent [RBE]) in 5 weeks. Target volumes included the breast/chest wall and regional lymph nodes including the internal mammary lymph nodes (in 93%). No patients required a treatment break. Among patients with >3 months of follow-up (n=28), grade 2 dermatitis occurred in 20 patients (71.4%), with 8 (28.6%) experiencing moist desquamation. Grade 2 esophagitis occurred in 8 patients (28.6%). Grade 3 reconstructive complications occurred in 1 patient. The median planning target volume V95 was 96.43% (range, 79.39%-99.60%). The median mean heart dose was 0.88 Gy (RBE) [range, 0.01-3.20 Gy (RBE)] for all patients, and 1.00 Gy (RBE) among patients with left-sided tumors. The median V20 of the ipsilateral lung was 16.50% (range, 6.1%-30.3%). The median contralateral lung V5 was 0.34% (range, 0%-5.30%). The median maximal point dose to the esophagus was 45.65 Gy (RBE) [range, 0-65.4 Gy (RBE)]. The median contralateral breast mean dose was 0.29 Gy (RBE) [range, 0.03-3.50 Gy (RBE)]. Conclusions: Postoperative proton therapy is well tolerated, with acceptable rates of skin toxicity. Proton therapy favorably spares normal tissue without compromising target coverage. Further follow-up is necessary to assess for clinical outcomes and cardiopulmonary

  7. Ovation Prime Real-Time

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Ovation Prime Real-Time (OPRT) product is a real-time forecast and nowcast model of auroral power and is an operational implementation of the work by Newell et...

  8. Cybersecurity Vulnerability Analysis of the PLC PRIME Standard

    Directory of Open Access Journals (Sweden)

    Miguel Seijo Simó

    2017-01-01

    Full Text Available Security in critical infrastructures such as the power grid is of vital importance. The Smart Grid puts power grid classical security approach on the ropes, since it introduces cyberphysical systems where devices, communications, and information systems must be protected. PoweRline Intelligent Metering Evolution (PRIME is a Narrowband Power-Line Communications (NB-PLC protocol widely used in the last mile of Advanced Metering Infrastructure (AMI deployments, playing a key role in the Smart Grid. Therefore, this work aims to unveil the cybersecurity vulnerabilities present in PRIME standard, proposing solutions and validating and discussing the results obtained.

  9. The Clinical Utility and Diagnostic Performance of MRI for Identification of Early and Advanced Knee Osteoarthritis: A Systematic Review

    Science.gov (United States)

    Quatman, Carmen E.; Hettrich, Carolyn M.; Schmitt, Laura C.; Spindler, Kurt P.

    2013-01-01

    Background Current diagnostic strategies for detection of structural articular cartilage abnormalities, the earliest structural signs of osteoarthritis, often do not capture the condition until it is too far advanced for the most potential benefit of non-invasive interventions. Purpose Systematically review the literature relative to the following questions: (1) Is MRI a valid, sensitive, specific, accurate and reliable instrument to identify knee articular cartilage abnormalities compared to arthroscopy? (2) Is MRI a sensitive tool that can be utilized to identify early cartilage degeneration? Study Design Systematic Review Methods A systematic search was performed in November 2010 using PubMed MEDLINE (from 1966), CINAHL (from 1982), SPORTDiscus (from 1985), and SCOPUS (from 1996) databases. Results Fourteen level I and 13 level II studies were identified that met inclusion criteria and provided information related to diagnostic performance of MRI compared to arthroscopic evaluation. The diagnostic performance of MRI demonstrated a large range of sensitivities, specificities, and accuracies. The sensitivity for identifying articular cartilage abnormalities in the knee joint was reported between 26–96%. Specificity and accuracy was reported between 50–100% and 49–94%, respectively. The sensitivity, specificity, and accuracy for identifying early osteoarthritis were reported between 0–86%, 48–95%, and 5–94%, respectively. As a result of inconsistencies between imaging techniques and methodological shortcomings of many of the studies, a meta-analysis was not performed and it was difficult to fully synthesize the information to state firm conclusions about the diagnostic performance of MRI. Conclusions There is evidence in some MRI protocols that MRI is a relatively valid, sensitive, specific, accurate, and reliable clinical tool for identifying articular cartilage degeneration. Due to heterogeneity of MRI sequences it is not possible to make definitive

  10. No priming for global motion in crowding.

    Science.gov (United States)

    Pavan, Andrea; Gall, Martin G; Manassi, Mauro; Greenlee, Mark W

    2015-01-01

    There is psychophysical evidence that low-level priming, e.g., from oriented gratings, as well as high-level semantic priming, survives crowding. We investigated priming for global translational motion in crowded and noncrowded conditions. The results indicated that reliable motion priming occurs in the noncrowded condition, but motion priming does not survive crowding. Crowding persisted despite variations in the direction of the flankers with respect to the prime's direction. Motion priming was still absent under crowding when 85% of the flankers moved in the same direction as the prime. Crowding also persisted despite variations in the speed of the flankers relative to the prime even when the flankers' speed was four times slower than the speed of the prime. However, a priming effect was evident when the prime's spatial location was precued and its distance to the flankers increased, suggesting a release from crowding. These results suggest that transient attention induced by precueing the spatial location of the prime may improve subjects' ability to discriminate its direction. Spatial cueing could act to decrease the integration field, thereby diminishing the influence of nearby distracters. In an additional experiment in which we used fewer flankers, we found a priming effect under conditions in which the interelement distance varied between flankers and prime. Overall, the results suggest that motion priming is strongly affected by crowding, but transient attention can partially retrieve such facilitation.

  11. Continued fractions constructed from prime numbers

    CERN Document Server

    Wolf, Marek

    2010-01-01

    We give 50 digits values of the simple continued fractions whose denominators are formed from a) prime numbers, b) twin primes, c) primes of the form m^2+1 and Mersenne primes. All these continued fractions belong to the set of measure zero of exceptions to the Khinchin Theorem.

  12. Psychotherapy augmentation through preconscious priming

    Directory of Open Access Journals (Sweden)

    Francois eBorgeat

    2013-03-01

    Full Text Available Objective: To test the hypothesis that repeated preconscious (masked priming of personalized positive cognitions could augment cognitive change and facilitate achievement of patients’ goals following a therapy.Methods: Twenty social phobic patients (13 women completed a 36 weeks study beginning by 12 weeks of group behavioural therapy. After the therapy, they received 6 weeks of preconscious priming and 6 weeks of a control procedure in a randomized cross-over design. The Priming condition involved listening twice daily with a passive attitude to a recording of individualized formulations of appropriate cognitions and attitudes masked by music. The Control condition involved listening to an indistinguishable recording where the formulations had been replaced by random numbers. Changes in social cognitions were measured by the Social Interaction Self Statements Test (SISST.Results: Patients improved following therapy. The Priming procedure was associated with increased positive cognitions and decreased negative cognitions on the SISST while the Control procedure was not. The Priming procedure induced more cognitive change when applied immediately after the group therapy. Conclusion: An effect of priming was observed on social phobia related cognitions in the expected direction. This self administered addition to a therapy could be seen as an augmentation strategy.

  13. Locus of single-prime negative priming: the role of perceptual form.

    Science.gov (United States)

    Chao, Hsuan-Fu

    2013-07-01

    Single-prime negative priming refers to the phenomenon in which after a single prime word is briefly presented, repeating it as the probe target results in a delay in responding to the target. The present study investigated the locus of this negative priming effect. Experiment 1 showed that repeating the identity of the prime produced a negative priming effect but merely repeating the response of the prime did not. Experiment 2 showed that the negative priming effect transformed into positive priming when the probe distractor was absent. Experiments 3 and 4 further revealed that single-prime negative priming was observed when the perceptual form was repeated. Taken together, these results suggest that single-prime negative priming involves a perceptual locus.

  14. Response Priming with More or Less Biological Movements as Primes.

    Science.gov (United States)

    Eckert, David; Bermeitinger, Christina

    2016-07-01

    Response priming in general is a suitable tool in cognitive psychology to investigate motor preactivations. Typically, compatibility effects reflect faster reactions in cases in which prime and target suggest the same response (i.e., compatible trials) compared with cases in which prime and target suggest opposite responses (i.e., incompatible trials). With moving dots that were horizontally aligned, Bermeitinger (2013) found a stable pattern of results: with short SOAs, faster responses in compatible trials were found; with longer SOAs up to 250 ms, faster responses in incompatible trials were found. It is unclear whether these results are specific to the special motion used therein or whether it generalizes to other motions. We therefore used other motions realized by arrangements of dots. In four experiments, we tested point-light displays (biological coherent walkers vs. less biological scrambled/split displays) as primes. In two experiments, eye gaze motions realized by moving dots representing irises and pupils (i.e., biological) versus the same motion either without surrounding face information or integrated in an abstract line drawing (i.e., less biological) were used. We found overall large positive compatibility effects with biological motion primes and also positive-but smaller-compatibility effects with less biological motion primes. Most important, also with very long SOAs (up to 1320 ms), we did not find evidence for negative compatibility effects. Thus, the pattern of positive-followed-by-negative-compatibility effects found in Bermeitinger (2013) seems to be specific to the materials used therein, whereas response priming in general seems an applicable tool to study motion perception.

  15. Sequential Stereotype Priming: A Meta-Analysis.

    Science.gov (United States)

    Kidder, Ciara K; White, Katherine R; Hinojos, Michelle R; Sandoval, Mayra; Crites, Stephen L

    2017-08-01

    Psychological interest in stereotype measurement has spanned nearly a century, with researchers adopting implicit measures in the 1980s to complement explicit measures. One of the most frequently used implicit measures of stereotypes is the sequential priming paradigm. The current meta-analysis examines stereotype priming, focusing specifically on this paradigm. To contribute to ongoing discussions regarding methodological rigor in social psychology, one primary goal was to identify methodological moderators of the stereotype priming effect-whether priming is due to a relation between the prime and target stimuli, the prime and target response, participant task, stereotype dimension, stimulus onset asynchrony (SOA), and stimuli type. Data from 39 studies yielded 87 individual effect sizes from 5,497 participants. Analyses revealed that stereotype priming is significantly moderated by the presence of prime-response relations, participant task, stereotype dimension, target stimulus type, SOA, and prime repetition. These results carry both practical and theoretical implications for future research on stereotype priming.

  16. The Intervenor Effect in Masked Priming: How Does Masked Priming Survive across an Intervening Word?

    Science.gov (United States)

    Forster, Kenneth I.

    2009-01-01

    Four masked priming experiments are reported investigating the effect of inserting an unrelated word between the masked prime and the target. When the intervening word is visible, identity priming is reduced to the level of one-letter-different form priming, but form priming is largely unaffected. However, when the intervening word is itself…

  17. On the Control of Single-Prime Negative Priming: The Effects of Practice and Time Course

    Science.gov (United States)

    Chao, Hsuan-Fu

    2009-01-01

    Single-prime negative priming refers to the phenomenon wherein repetition of a prime as the probe target results in delayed response. Sometimes this effect has been found to be contingent on participants' unawareness of the primes, and sometimes it has not. Further, sometimes this effect has been found to be eliminated when the prime could predict…

  18. On the Control of Single-Prime Negative Priming: The Effects of Practice and Time Course

    Science.gov (United States)

    Chao, Hsuan-Fu

    2009-01-01

    Single-prime negative priming refers to the phenomenon wherein repetition of a prime as the probe target results in delayed response. Sometimes this effect has been found to be contingent on participants' unawareness of the primes, and sometimes it has not. Further, sometimes this effect has been found to be eliminated when the prime could predict…

  19. The Intervenor Effect in Masked Priming: How Does Masked Priming Survive across an Intervening Word?

    Science.gov (United States)

    Forster, Kenneth I.

    2009-01-01

    Four masked priming experiments are reported investigating the effect of inserting an unrelated word between the masked prime and the target. When the intervening word is visible, identity priming is reduced to the level of one-letter-different form priming, but form priming is largely unaffected. However, when the intervening word is itself…

  20. Advanced radiological work-up as an adjunct to decision in early reconstructive surgery in brachial plexus injuries

    Directory of Open Access Journals (Sweden)

    Björkman Anders

    2010-07-01

    Full Text Available Abstract Background As neurophysiologic tests may not reveal the extent of brachial plexus injury at the early stage, the role of early radiological work-up has become increasingly important. The aim of the study was to evaluate the concordance between the radiological and clinical findings with the intraoperative findings in adult patients with brachial plexus injuries. Methods Seven consecutive male patients (median age 33; range 15-61 with brachial plexus injuries, caused by motor cycle accidents in 5/7 patients, who underwent extensive radiological work-up with magnetic resonance imaging (MRI, computed tomography myelography (CT-M or both were included in this retrospective study. A total of 34 spinal nerve roots were evaluated by neuroradiologists at two different occasions. The degree of agreement between the radiological findings of every individual nerve root and the intraoperative findings was estimated by calculation of kappa coefficient (К-value. Using the operative findings as a gold standard, the accuracy, sensitivity, specificity, positive predictive value (PPV and negative predictive value (NPV of the clinical findings and the radiological findings were estimated. Results The diagnostic accuracy of radiological findings was 88% compared with 65% for the clinical findings. The concordance between the radiological findings and the intraoperative findings was substantial (К = 0.76 compared with only fair (К = 0.34 for the clinical findings. There were two false positive and two false negative radiological findings (sensitivity and PPV of 0.90; specificity and NPV of 0.87. Conclusions The advanced optimized radiological work-up used showed high reliability and substantial agreement with the intraoperative findings in adult patients with brachial plexus injury.

  1. Prediction of response by FDG PET early during concurrent chemoradiotherapy for locally advanced non-small cell lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Su Zi; Oh, So Won; Kim, Jin Soo; Kim, Ki Hwan; Kim, Yu Kyeong [SMG-Seoul National University Boramae Medical Center, Seoul (Korea, Republic of)

    2014-12-15

    To evaluate the predictive value of the early response of 18F-flurodeoxyglucose positron emission tomography (FDG PET) during concurrent chemoradiotherapy (CCRT) for locally advanced non-small cell lung cancer (NSCLC). FDG PET was performed before and during CCRT for 13 NSCLC patients. Maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and the changes were calculated. These early metabolic changes were compared with the standard tumor response by computed tomograms (CT) one month after CCRT.One month after the completion of CCRT, 9 patients had partial response (PR) of tumor and 4 patients had stable disease. The percent changes of SUVmax (%DeltaSUVmax) were larger in responder group than in non-responder group (55.7% +/- 15.6% vs. 23.1% +/- 19.0%, p = 0.01). The percent changes of SUVmean (%DeltaSUVmean) were also larger in responder group than in non-responder group (54.4% +/- 15.9% vs. 22.3% +/- 23.0%, p = 0.01). The percent changes of MTV (%DeltaMTV) or TLG (%DeltaTLG) had no correlation with the tumor response after treatment. All the 7 patients (100%) with %DeltaSUVmax > or = 50% had PR, but only 2 out of 6 patients (33%) with %DeltaSUVmax < 50% had PR after CCRT (p = 0.009). Likewise, all the 6 patients (100%) with %DeltaSUVmean > or = 50% had PR, but only 3 out of 7 patients (43%) with %DeltaSUVmean < 50% had PR after CCRT (p = 0.026). The degree of metabolic changes measured by PET-CT during CCRT was predictive for NSCLC tumor response after CCRT.

  2. The Implementation and Effects of the Literacy Design Collaborative (LDC): Early Findings in Sixth-Grade Advanced Reading Courses. CRESST Report 846

    Science.gov (United States)

    Herman, Joan L.; Epstein, Scott; Leon, Seth; Dai, Yunyun; La Torre Matrundola, Deborah; Reber, Sarah; Choi, Kilchan

    2015-01-01

    The Bill and Melinda Gates Foundation invested in the Literacy Design Collaborative (LDC) as one strategy to support teachers' and students' transition to the Common Core State Standards (CCSS) in English language arts. This report provides an early look at the implementation of LDC in sixth-grade Advanced Reading classes in a large Florida…

  3. The occurrence of prime numbers revisited

    OpenAIRE

    Ernesto Tapia Moore; José Tapia Yañez

    2016-01-01

    Based on an arithmetical and autocatalytic approach, the authors propose a solution for the occurrence of prime numbers. Exact arithmetical calculations are provided for: the closest prime to any given positive integer (or any number of bigger or smaller primes from that integer); the quantity of prime (and composite) numbers between 1 and any positive integer; the quantity of prime (and composite) numbers between any two positive integers.

  4. The occurrence of prime numbers revisited

    Directory of Open Access Journals (Sweden)

    Ernesto Tapia Moore

    2016-03-01

    Full Text Available Based on an arithmetical and autocatalytic approach, the authors propose a solution for the occurrence of prime numbers. Exact arithmetical calculations are provided for: the closest prime to any given positive integer (or any number of bigger or smaller primes from that integer; the quantity of prime (and composite numbers between 1 and any positive integer; the quantity of prime (and composite numbers between any two positive integers.

  5. The Affective Regulation of Cognitive Priming

    OpenAIRE

    Storbeck, Justin; Clore, Gerald L.

    2008-01-01

    Semantic and affective priming are classic effects observed in cognitive and social psychology, respectively. We discovered that affect regulates such priming effects. In Experiment 1, positive and negative moods were induced prior to one of three priming tasks; evaluation, categorization, or lexical decision. As predicted, positive affect led to both affective priming (evaluation task) and semantic priming (category and lexical decision tasks). However, negative affect inhibited such effects...

  6. "Replicable effects of primes on human behavior": Correction to Payne et al. (2016).

    Science.gov (United States)

    2016-12-01

    Reports an error in "Replicable effects of primes on human behavior" by B. Keith Payne, Jazmin L. Brown-Iannuzzi and Chris Loersch (Journal of Experimental Psychology: General, 2016[Oct], Vol 145[10], 1269-1279). In the article, the graph in Figure 5 did not contain the asterisk mentioned in the figure caption, which was intended to indicate a statistically significant difference between bet and pass prime. The online version of this article has been corrected. (The following abstract of the original article appeared in record 2016-46925-002.) The effect of primes (i.e., incidental cues) on human behavior has become controversial. Early studies reported counterintuitive findings, suggesting that primes can shape a wide range of human behaviors. Recently, several studies failed to replicate some earlier priming results, raising doubts about the reliability of those effects. We present a within-subjects procedure for priming behavior, in which participants decide whether to bet or pass on each trial of a gambling game. We report 6 replications (N = 988) showing that primes consistently affected gambling decisions when the decision was uncertain. Decisions were influenced by primes presented visibly, with a warning to ignore the primes (Experiments 1 through 3) and with subliminally presented masked primes (Experiment 4). Using a process dissociation procedure, we found evidence that primes influenced responses through both automatic and controlled processes (Experiments 5 and 6). Results provide evidence that primes can reliably affect behavior, under at least some conditions, without intention. The findings suggest that the psychological question of whether behavior priming effects are real should be separated from methodological issues affecting how easily particular experimental designs will replicate. (PsycINFO Database Record

  7. A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Sun Young Yi; Woon Jung Lee

    2006-01-01

    AIM: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients.METHODS:DNA was extracted from blood samples of gastric cancer patients (n = 291) and controls (n=216).tn the p53 codon 72 genotypes were determined by PCR-RFLP.RESULTS: Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P=0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine)allele (P=0.038) than EGC and a similar Pro/Pro allele.The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P=0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI,1.3-15.4,P=0.039)when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI,1.8-19.6,P=0.021).CONCLUSION: The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC.

  8. Differentiation of early gastric cancer with ulceration and resectable advanced gastric cancer using multiphasic dynamic multidetector CT

    Energy Technology Data Exchange (ETDEWEB)

    Tsurumaru, Daisuke; Miyasaka, Mitsutoshi; Nishimuta, Yusuke; Asayama, Yoshiki; Nishie, Akihiro; Honda, Hiroshi [Kyushu University, Department of Clinical Radiology, Graduate School of Medical Sciences, Fukuoka (Japan); Kawanami, Satoshi [Kyushu University, Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Fukuoka (Japan); Oki, Eiji [Kyushu University, Department of Surgery and Sciences, Graduate School of Medical Sciences, Fukuoka (Japan); Hirahashi, Minako [Kyushu University, Department of Anatomic Pathology and Pathological Sciences, Graduate School of Medical Sciences, Fukuoka (Japan)

    2016-05-15

    Early gastric cancer with ulceration (EGC-U) mimics advanced gastric cancer (AGC), as EGC-Us and ACGs often have similar endoscopic appearance to ulceration. The purpose of this retrospective study was to determine whether multiphasic dynamic multidetector CT (MDCT) can help differentiate EGC-Us from AGCs. Patients with EGC-Us with ulcer stages Ul-III or IV and AGCs with tumour stages T2 to T4a were enrolled. MDCT images were obtained 40 s (arterial phase), 70 s (portal phase) and 240 s (delayed phase) after injection of non-ionic contrast material. Two readers independently measured the attenuation values of the lesions by placing regions of interest. We compared the EGC-Us and AGCs using the mean attenuation values in each phase and peak enhancement phase. We analysed the diagnostic performance of CT for differentiating EGC-Us from AGCs. Forty cases (16 EGC-Us and 24 AGCs) were analysed. The mean attenuation values of the EGC-Us were significantly lower than those of the AGCs in both the arterial and portal phases (all p < 0.0001 for each reader). The peak enhancement was significantly different between the EGC-Us and AGCs for both readers (Reader 1, p = 0.0131; Reader 2, p = 0.0006). Multiphasic dynamic contrast-enhanced MDCT can help differentiate EGC-Us from AGCs. (orig.)

  9. Promoting research in advanced dementia: early clinical results of the Alzheimer Center Reina Sofía Foundation.

    Science.gov (United States)

    Olazarán, Javier; Agüera-Ortiz, Luis; Osorio, Ricardo S; León-Salas, Beatriz; Dobato, José Luis; Cruz-Orduña, Isabel; González, Belén; Valentí, Meritxell; Gil-Ruiz, Nuria; Frades, Belén; Ramos-García, M I; Martínez-Martín, Pablo

    2012-01-01

    The Alzheimer Center Reina Sofía Foundation (ACRSF) was envisaged to address the complex and multi-disciplinary research and care needs posed by Alzheimer's disease (AD) and other neurodegenerative dementias. Patients may be admitted at ACRSF either as inpatients (i.e., nursing home) or outpatients (i.e., day-care center). The research program includes clinical, social, biochemical, genetic, and magnetic resonance investigations, as well as brain donation. We present the inception of the clinical research protocol for the ACRSF, the early results, and the amendments to the protocol. Foreseen as distinct populations, inpatient and outpatient results are presented separately. Data were collected from 180 patients (153 inpatients, 27 outpatients) (86% AD), with informed consent for participation in the research program of the ACRSF. Most patients (95%) had moderate to severe dementia. Nursing home patients were older, displayed marked gait dysfunction, and were significantly more dependent in the activities of daily living (ADL), compared to the day-care patients (p dementia. New measurements were added for evaluation of cognition, apathy, agitation, depression, ADL, motor function, and QoL. The final assessment is expected to be sensitive to change in all the clinical aspects of advanced degenerative dementia, to promote multidisciplinary and, desirably, inter-center collaborative research and, eventually, to contribute to the improvement of treatment and care for these patients.

  10. Priming and Habituation for Faces: Individual Differences and Inversion Effects

    Science.gov (United States)

    Rieth, Cory A.; Huber, David E.

    2010-01-01

    Immediate repetition priming for faces was examined across a range of prime durations in a threshold identification task. Similar to word repetition priming results, short duration face primes produced positive priming whereas long duration face primes eliminated or reversed this effect. A habituation model of such priming effects predicted that…

  11. Priming and Habituation for Faces: Individual Differences and Inversion Effects

    Science.gov (United States)

    Rieth, Cory A.; Huber, David E.

    2010-01-01

    Immediate repetition priming for faces was examined across a range of prime durations in a threshold identification task. Similar to word repetition priming results, short duration face primes produced positive priming whereas long duration face primes eliminated or reversed this effect. A habituation model of such priming effects predicted that…

  12. Italy's Prime Minister visits CERN

    CERN Document Server

    Stefania Pandolfi

    2015-01-01

    On Tuesday, 7 July 2015, the Prime Minister of the Italian Republic, Matteo Renzi, visited CERN. He was accompanied by a delegation that included Italy's Minister for Education, University and Research, Stefania Giannini.   From left to right: Fernando Ferroni, President of the Istituto Nazionale di Fisica Nucleare (INFN); Sergio Bertolucci, CERN Director for Research and Scientific Computing; Stefania Giannini, Italy's Minister of Education, University and Research; Matteo Renzi, Prime Minister of the Italian Republic; Fabiola Gianotti, CERN Director-General Designate; Rolf Heuer, CERN Director-General.   The Prime Minister was welcomed by members of the CERN Management together with former CERN Director-General and Senator for Life of the Italian Republic, Carlo Rubbia. After a brief general introduction to CERN’s activities by Rolf Heuer, the Italian delegation visited LHC Point 1. After a tour of the ATLAS control room, they donned helmets to visit th...

  13. Determination of an optimal priming duration and concentration protocol for pepper seeds (Capsicum annuum L.

    Directory of Open Access Journals (Sweden)

    Hassen ALOUI

    2015-12-01

    Full Text Available Seed priming is a simple pre-germination method to improve seed performance and to attenuate the effects of stress exposure. The objective of this study was to determinate an optimal priming protocol for three pepper cultivars (Capsicum annuum L.: ‘Beldi’, ‘Baklouti’ and ‘Anaheim Chili’. Seeds were primed with three solutions of NaCl, KCl and CaCl2 (0, 10, 20 and 50 mM for three different durations (12, 24 and 36h. Control seeds were soaked in distilled water for the same durations. After that, all seeds were kept to germinate in laboratory under normal light and controlled temperature. Results indicated that priming depends on concentration, duration and cultivar. The best combinations that we obtained were: KCl priming (10 mM, 36h for ‘Beldi’ cultivar, CaCl2 priming (10 mM, 36h for ‘Baklouti’ cultivar and finally NaCl priming (50 mM, 24h for ‘Anaheim Chili’ cultivar. Generally, priming had an effect on total germination percentage, mean germination time, germination index and the coefficient of velocity compared to control seeds. The beneficial effect of seed priming could be used for improving salt tolerance on germination and early seedling growth for pepper cultivar.

  14. Seed Priming with Selenium: Consequences for Emergence, Seedling Growth, and Biochemical Attributes of Rice.

    Science.gov (United States)

    Khaliq, Abdul; Aslam, Farhena; Matloob, Amar; Hussain, Saddam; Geng, Mingjian; Wahid, Abdul; ur Rehman, Hafeez

    2015-08-01

    The present study was undertaken to appraise the role of selenium priming for improving emergence and seedling growth of basmati rice. Seeds of two fine rice cultivars (Super and Shaheen Basmati) were primed with concentrations of 15, 30, 45, 60, 75, 90, and 105 μmol L(-1) selenium. Untreated dry- and hydro-primed seeds were maintained as the control and positive control, respectively. Selenium priming resulted in early commencement of emergence, triggered seedling growth irrespective of rice cultivar over untreated control, and was more effective than hydro-priming except at higher concentrations. Lower electrical conductivity of seed leachates, reduced lipid peroxidation, greater α-amylase activity, higher soluble sugars, and enhanced activities of enzymatic antioxidants (superoxide dismutase (SOD), peroxidase (POX), catalase (CAT), and glutathione peroxidase (GPX)) were observed in seeds primed with selenium. Rice seedlings derived from selenium-primed seeds exhibited more chlorophyll contents, while total phenolics were comparable with those of the control seedlings. The improved starch metabolism, greater membrane stability, and increased activity of antioxidants were considered as possible mechanisms responsible for such improvements in emergence and seedling vigor of rice mediated by selenium priming. Priming with selenium (15-60 μmol L(-1)) favored rice emergence and seedling growth. Nevertheless, soaking seeds in relatively concentrated (90 and 105 μmol L(-1)) selenium solution had overall detrimental effects.

  15. Impact Craters as Habitats for Life on Early Mars

    Science.gov (United States)

    Osinski, G. R.; Tornabene, L. L.; Banerjee, N. R.; Cockell, C. S.; Flemming, R.; Izawa, M. R. M.; McCutcheon, J.; Pontefract, A.; Parnell, J.; Sapers, H.; Southam, G.

    2012-05-01

    In this contribution we present a case that impact craters on Early Mars would have represented prime habitats for life, and potentially for its origin, and that impact craters, therefore, should be prime exploration targets for future missions.

  16. Wetting and greening Tibetan Plateau in early summer since the late 1970s due to advanced Asian summer monsoon onset

    Science.gov (United States)

    Zhang, Wenxia; Zhou, Tianjun; Zhang, Lixia

    2016-04-01

    Known as the "the world water tower", the Tibetan Plateau (TP) is the origin of the ten largest rivers in Asia, breeding more than 1.4 billion people, and exerts substantial influences on water resources, agriculture, and ecosystems in downstream countries. This region is one of the most susceptible areas around the world to changing climate due to the high elevation. Observed evidence have shown significant climate changes over the TP, including surface air warming and moistening, glaciers shrinking, winds stilling, solar dimming, and atmospheric heat source weakening. However, as an essential part of the hydrological cycle, precipitation changes on the TP remain an ambiguous picture. Changes in precipitation vary largely with different seasons, time periods and climate zones considered. This study shows a robust increase in precipitation amount over the TP in May, when the rainy season starts, over the period 1979-2014 (31% relative to the climatology). The wetting trend is spatially consistent over the south-eastern TP, to which both precipitation frequency and intensity contribute. Circulation trends show that the wetting TP in May is resulted from the advanced onset of Asian summer monsoon, which onsets 1~2 pentads earlier since 1979. It intensified water vapor transport from the Bay of Bengal (BOB) to south of the TP in May and local anomalous convection. This relationship is further validated by the significant correlation coefficient (0.47) between the onset dates of Asian summer monsoon (particularly the BOB summer monsoon, 0.68) and precipitation over the south-eastern TP in May. The wetting TP in May has further exerted profound impacts on the hydrological cycle and ecosystem, such as moistening the soil and animating vegetation activities throughout early summer. Both decadal variations of soil moisture (from May to June) and Normalized Difference Vegetation Index (NDVI) (from May to July) coincide well with that of precipitation over the south

  17. Tissue Doppler Imaging Combined with Advanced 12-Lead ECG Analysis Might Improve Early Diagnosis of Hypertrophic Cardiomyopathy in Childhood

    Science.gov (United States)

    Femlund, E.; Schlegel, T.; Liuba, P.

    2011-01-01

    Optimization of early diagnosis of childhood hypertrophic cardiomyopathy (HCM) is essential in lowering the risk of HCM complications. Standard echocardiography (ECHO) has shown to be less sensitive in this regard. In this study, we sought to assess whether spatial QRS-T angle deviation, which has shown to predict HCM in adults with high sensitivity, and myocardial Tissue Doppler Imaging (TDI) could be additional tools in early diagnosis of HCM in childhood. Methods: Children and adolescents with familial HCM (n=10, median age 16, range 5-27 years), and without obvious hypertrophy but with heredity for HCM (n=12, median age 16, range 4-25 years, HCM or sudden death with autopsy-verified HCM in greater than or equal to 1 first-degree relative, HCM-risk) were additionally investigated with TDI and advanced 12-lead ECG analysis using Cardiax(Registered trademark) (IMED Co Ltd, Budapest, Hungary and Houston). Spatial QRS-T angle (SA) was derived from Kors regression-related transformation. Healthy age-matched controls (n=21) were also studied. All participants underwent thorough clinical examination. Results: Spatial QRS-T angle (Figure/ Panel A) and septal E/Ea ratio (Figure/Panel B) were most increased in HCM group as compared to the HCM-risk and control groups (p less than 0.05). Of note, these 2 variables showed a trend toward higher levels in HCM-risk group than in control group (p=0.05 for E/Ea and 0.06 for QRS/T by ANOVA). In a logistic regression model, increased SA and septal E/Ea ratio appeared to significantly predict both the disease (Chi-square in HCM group: 9 and 5, respectively, p less than 0.05 for both) and the risk for HCM (Chi-square in HCM-risk group: 5 and 4 respectively, p less than 0.05 for both), with further increased predictability level when these 2 variables were combined (Chi-square 10 in HCM group, and 7 in HCM-risk group, p less than 0.01 for both). Conclusions: In this small material, Tissue Doppler Imaging and spatial mean QRS-T angle

  18. Instant PrimeFaces starter

    CERN Document Server

    Hlavats, Ian

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant Primefaces Starter is a fast-paced, introductory guide designed to give you all the information you need to start using Primfaces, instantly.Instant PrimeFaces Starter is great for developers looking to get started quickly with PrimeFaces. It's assumed that you have some JSF experience already, as well as familiarity with other Java technologies such as CDI and JPA and an understanding of MVC principles, object-relational mapping (ORM),

  19. Physiological and biochemical mechanisms of seed priming-induced chilling tolerance in rice cultivars

    Directory of Open Access Journals (Sweden)

    Saddam eHussain

    2016-02-01

    Full Text Available Rice belongs to tropical and subtropical environments and is extremely sensitive to chilling stress particularly during emergence and early stages of seedling development. Seed priming can be a good approach to enhance rice germination and stand establishment under chilling stress. The present study examined the role of different seed priming techniques viz., hydropriming, osmopriming, redox priming, chemical priming, and hormonal priming, in enhancing the chilling tolerance in rice. The most effective reagents and their pre-optimized concentrations based on preliminary experiments were used in this study. Two different rice cultivars were sown under chilling stress (18˚C and normal temperatures (28˚C in separate growth chambers. A non-primed control treatment was also maintained for comparison. Chilling stress caused erratic and delayed germination, poor seedling growth, reduced starch metabolism and lower respiration rate, while higher lipid peroxidation and hydrogen peroxide accumulation in rice seedlings of both cultivars. Nevertheless, all the seed priming treatments effectively alleviated the negative effects of chilling stress. In addition, seed priming treatments triggered the activities of superoxide dismutase, peroxidase, and catalase, and enhanced the accumulations of glutathione and free proline in rice seedlings, which suggests that these measures help prevent the rice seedlings from chilling induced oxidative stress. Chemical priming with selenium and hormonal priming with salicylic acid remained more effective treatments for both rice cultivars under chilling stress than all other priming treatments. The better performance and greater tolerance of primed rice seedlings was associated with enhanced starch metabolism, high respiration rate, lower lipid peroxidation, and strong antioxidative defense system under chilling stress.

  20. Impedance-matching hearing in Paleozoic reptiles: evidence of advanced sensory perception at an early stage of amniote evolution.

    Directory of Open Access Journals (Sweden)

    Johannes Müller

    Full Text Available BACKGROUND: Insights into the onset of evolutionary novelties are key to the understanding of amniote origins and diversification. The possession of an impedance-matching tympanic middle ear is characteristic of all terrestrial vertebrates with a sophisticated hearing sense and an adaptively important feature of many modern terrestrial vertebrates. Whereas tympanic ears seem to have evolved multiple times within tetrapods, especially among crown-group members such as frogs, mammals, squamates, turtles, crocodiles, and birds, the presence of true tympanic ears has never been recorded in a Paleozoic amniote, suggesting they evolved fairly recently in amniote history. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we performed a morphological examination and a phylogenetic analysis of poorly known parareptiles from the Middle Permian of the Mezen River Basin in Russia. We recovered a well-supported clade that is characterized by a unique cheek morphology indicative of a tympanum stretching across large parts of the temporal region to an extent not seen in other amniotes, fossil or extant, and a braincase specialized in showing modifications clearly related to an increase in auditory function, unlike the braincase of any other Paleozoic tetrapod. In addition, we estimated the ratio of the tympanum area relative to the stapedial footplate for the basalmost taxon of the clade, which, at 23:1, is in close correspondence to that of modern amniotes capable of efficient impedance-matching hearing. CONCLUSIONS/SIGNIFICANCE: Using modern amniotes as analogues, the possession of an impedance-matching middle ear in these parareptiles suggests unique ecological adaptations potentially related to living in dim-light environments. More importantly, our results demonstrate that already at an early stage of amniote diversification, and prior to the Permo-Triassic extinction event, the complexity of terrestrial vertebrate ecosystems had reached a level that

  1. Comorbidity, Use of Common Medications, and Risk of Early Death in Patients with Localized or Locally Advanced Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Carsten Nieder

    2011-01-01

    Full Text Available In this paper, we analyze predictive factors for early death from comorbidity (defined as death within 3 years from diagnosis and unrelated to prostate cancer in patients with localized or locally advanced prostate cancer. Such information may guide individually tailored treatment or observation strategies, and help to avoid overtreatment. We retrospectively analyzed baseline parameters including information on comorbidity and medication use among 177 patients (median age at diagnosis 70 years. Actuarial survival analyses were performed. During the first 3 years, two patients (1.1% died from progressive prostate cancer after they had developed distant metastases. The risk of dying from other causes (3.4% was numerically higher, although not to a statistically significant degree. Six patients who died from other causes had age-adjusted Charlson comorbidity index (CCI scores ≥5 (CCI is a sum score where each comorbid condition is assigned with a score depending on the risk of dying associated with this condition. The main comorbidity was cardiovascular disease. The two statistically significant predictive factors were medication use and age-adjusted CCI score ≥5 (univariate analysis. However, medication use was not an independent factor as all patients with age-adjusted CCI score ≥5 also used at least one class of medication. Median survival was 30 months in patients with age-adjusted CCI score ≥5. Prediction of non-prostate cancer death may be important to prevent overtreatment in patients who are more threatened by comorbidity. Our data suggest that simple parameters such as use of medications vs. none, or presence of serious cardiac disease vs. none, are not sufficient, and that age-adjusted CCI scores outperform the other factors included in our analysis.

  2. Epigenetic priming of the metabolic syndrome.

    Science.gov (United States)

    Bruce, Kimberley D; Cagampang, Felino R

    2011-05-01

    The metabolic syndrome (MetS) represents a cluster of cardiometabolic risk factors, including central obesity, insulin resistance, glucose intolerance, dyslipidemia, hypertension, hyperinsulinemia and microalbuminuria, and more recently, nonalcoholic fatty liver disease (NAFLD), polycystic ovarian syndrome (PCOS) and atherosclerosis. Although the concept of the MetS is subject to debate due to lack of a unifying underlying mechanism, the prevalence of a metabolic syndrome phenotype is rapidly increasing worldwide. Moreover, it is increasingly prevalent in children and adolescents of obese mothers. Evidence from both epidemiological and experimental animal studies now demonstrates that MetS onset is increasingly likely following exposure to suboptimal nutrition during critical periods of development, as observed in maternal obesity. Thus, the developmental priming of the MetS provides a common origin for this multifactorial disorder. Consequently, the mechanisms leading to this developmental priming have recently been the subject of intensive investigation. This review discusses recent data regarding the epigenetic modifications resulting from nutrition during early development that mediate persistent changes in the expression of key metabolic genes and contribute toward an adult metabolic syndrome phenotype. In addition, this review considers the role of the endogenous molecular circadian clock system, which has the potential to act at the interface between nutrient sensing and epigenetic processing. A continued and greater understanding of these mechanisms will eventually aid in the identification of individuals at high risk of cardiovascular disease (CVD) and type 2 diabetes, and help develop therapeutic interventions, in accordance with current global government strategy.

  3. CD4+ T-cell priming as biomarker to study immune response to preventive vaccines

    Directory of Open Access Journals (Sweden)

    Annalisa eCiabattini

    2013-12-01

    Full Text Available T-cell priming is a critical event in the initiation of the immune response to vaccination since it deeply influences both the magnitude and the quality of the immune response induced. CD4+ T-cell priming, required for the induction of high-affinity antibodies and immune memory, represents a key target for improving and modulating vaccine immunogenicity. A major challenge in the study of in vivo T-cell priming is due to the low frequency of antigen-specific T cells. This review discusses the current knowledge on antigen-specific CD4+ T-cell priming in the context of vaccination, as well as the most advanced tools for the characterization of the in vivo T-cell priming and the opportunities offered by the application of systems biology.

  4. Characteristic of Rings. Prime Fields

    Directory of Open Access Journals (Sweden)

    Schwarzweller Christoph

    2015-12-01

    Full Text Available The notion of the characteristic of rings and its basic properties are formalized [14], [39], [20]. Classification of prime fields in terms of isomorphisms with appropriate fields (ℚ or ℤ/p are presented. To facilitate reasonings within the field of rational numbers, values of numerators and denominators of basic operations over rationals are computed.

  5. Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer.

    Science.gov (United States)

    Ayyildiz, Talat; Dolar, Enver; Ugras, Nesrin; Dizdar, Oguzhan Sitki; Adim, Saduman Balaban; Yerci, Omer

    2014-01-01

    Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor 1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer. The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival. Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study. Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival. Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.

  6. Modification of initial therapy in early and advanced Hodgkin lymphoma, based on interim PET/CT is beneficial: a prospective multicentre trial of 355 patients.

    Science.gov (United States)

    Dann, Eldad J; Bairey, Osnat; Bar-Shalom, Rachel; Mashiach, Tanya; Barzilai, Elinor; Kornberg, Abraham; Akria, Luiza; Tadmor, Tamar; Filanovsky, Kalman; Abadi, Uri; Kagna, Olga; Ruchlemer, Rosa; Abdah-Bortnyak, Roxolyana; Goldschmidt, Neta; Epelbaum, Ron; Horowitz, Netanel A; Lavie, David; Ben-Yehuda, Dina; Shpilberg, Ofer; Paltiel, Ora

    2017-09-01

    This multicentre study evaluated 5-year progression-free (PFS) and overall survival (OS) in early and advanced Hodgkin lymphoma (HL), where therapy was individualized based on initial prognostic factors and positron emission tomography-computed tomography performed after two cycles (PET-2). Between September 2006 and August 2013, 359 patients aged 18-60 years, were recruited in nine Israeli centres. Early-HL patients initially received ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) ×2. Depending on initial unfavourable prognostic features, PET-2-positive patients received additional ABVD followed by involved-site radiotherapy (ISRT). Patients with negative PET-2 and favourable disease received ISRT or ABVD ×2; those with unfavourable disease received ABVD ×2 with ISRT or, alternatively, ABVD ×4. Advanced-HL patients initially received ABVD ×2 or escalated BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, prednisone; EB) ×2 based on their international prognostic score (≤2 or ≥3). PET-2-negative patients further received ABVD ×4; PET-2-positive patients received EB ×4 and ISRT to residual masses. With a median follow-up of 55 (13-119) months, 5-year PFS was 91% and 69% for PET-2-negative and positive early-HL, respectively; 5-year OS was 100% and 95%, respectively. For advanced-HL, the PFS was 81% and 68%, respectively (P = 0·08); 5-year OS was 98% and 91%, respectively. PET-2 positivity is associated with inferior prognosis in early-HL, even with additional ABVD and ISRT. Advanced-HL patients benefit from therapy escalation following positive PET-2. EB can be safely de-escalated to ABVD in PET-2-negative patients. © 2017 John Wiley & Sons Ltd.

  7. The effects of implicit and explicit security priming on creative problem solving.

    Science.gov (United States)

    Mikulincer, Mario; Shaver, Phillip R; Rom, Eldad

    2011-04-01

    Attachment theory is a theory of affect regulation as it occurs in the context of close relationships. Early research focused on regulation of emotions through maintenance of proximity to supportive others (attachment figures) in times of need. Recently, emphasis has shifted to the regulation of emotion, and the benefits of such regulation for exploration and learning, via the activation of mental representations of attachment figures (security priming). We conducted two studies on the effects of implicit and explicit security priming on creative problem solving. In Study 1, implicit security priming (subliminal presentation of attachment figures' names) led to more creative problem solving (compared with control conditions) regardless of dispositional attachment anxiety and avoidance. In Study 2, the effects of explicit security priming (recalling experiences of being well cared for) were moderated by anxiety and avoidance. We discuss the link between attachment and exploration and the different effects of implicit and explicit security priming.

  8. Selective attention modulates visual and haptic repetition priming: effects in aging and Alzheimer's disease.

    Science.gov (United States)

    Ballesteros, Soledad; Reales, José M; Mayas, Julia; Heller, Morton A

    2008-08-01

    In two experiments, we examined the effect of selective attention at encoding on repetition priming in normal aging and Alzheimer's disease (AD) patients for objects presented visually (experiment 1) or haptically (experiment 2). We used a repetition priming paradigm combined with a selective attention procedure at encoding. Reliable priming was found for both young adults and healthy older participants for visually presented pictures (experiment 1) as well as for haptically presented objects (experiment 2). However, this was only found for attended and not for unattended stimuli. The results suggest that independently of the perceptual modality, repetition priming requires attention at encoding and that perceptual facilitation is maintained in normal aging. However, AD patients did not show priming for attended stimuli, or for unattended visual or haptic objects. These findings suggest an early deficit of selective attention in AD. Results are discussed from a cognitive neuroscience approach.

  9. Competition Effects in Phonological Priming: The Role of Mismatch Position between Primes and Targets

    Science.gov (United States)

    Dufour, Sophie; Peereman, Ronald

    2009-01-01

    In three experiments, we examined lexical competition effects using the phonological priming paradigm in a shadowing task. Experiments 1A and 1B showed that an inhibitory priming effect occurred when the primes mismatched the targets on the last phoneme (/bagar/-/bagaj/). In contrast, a facilitatory priming effect was observed when the primes…

  10. Sandwich Priming: A Method for Overcoming the Limitations of Masked Priming by Reducing Lexical Competitor Effects

    Science.gov (United States)

    Lupker, Stephen J.; Davis, Colin J.

    2009-01-01

    An orthographically similar masked nonword prime facilitates responding in a lexical decision task (Forster & Davis, 1984). Recently, this masked priming paradigm has been used to evaluate models of orthographic coding--models that attempt to quantify prime-target similarity. One general finding is that priming effects often do not occur when…

  11. Affective Priming with Associatively Acquired Valence

    Science.gov (United States)

    Aguado, Luis; Pierna, Manuel; Saugar, Cristina

    2005-01-01

    Three experiments explored the effect of affectively congruent or incongruent primes on evaluation responses to positive or negative valenced targets (the "affective priming" effect). Experiment 1 replicated the basic affective priming effect with Spanish nouns: reaction time for evaluative responses (pleasant/unpleasant) were slower on…

  12. Structural Priming and Second Language Learning

    Science.gov (United States)

    Shin, Jeong-Ah; Christianson, Kiel

    2012-01-01

    Structural priming (or syntactic priming) is a speaker's tendency to reuse the same structural pattern as one that was previously encountered (Bock, 1986). This study investigated (a) whether the implicit learning processes involved in long-lag structural priming lead to differential second language (L2) improvement in producing two structural…

  13. Affective Priming with Auditory Speech Stimuli

    Science.gov (United States)

    Degner, Juliane

    2011-01-01

    Four experiments explored the applicability of auditory stimulus presentation in affective priming tasks. In Experiment 1, it was found that standard affective priming effects occur when prime and target words are presented simultaneously via headphones similar to a dichotic listening procedure. In Experiment 2, stimulus onset asynchrony (SOA) was…

  14. Affective priming with auditory speech stimuli

    NARCIS (Netherlands)

    Degner, J.

    2011-01-01

    Four experiments explored the applicability of auditory stimulus presentation in affective priming tasks. In Experiment 1, it was found that standard affective priming effects occur when prime and target words are presented simultaneously via headphones similar to a dichotic listening procedure. In

  15. Bol loops of odd prime exponent

    CERN Document Server

    Foguel, Tuval

    2009-01-01

    Although any finite Bol loop of odd prime exponent is solvable, we show there exist such Bol loops with trivial center. We also construct finitely generated, infinite, simple Bruck loops of odd prime exponent for sufficiently large primes. This shows that the Burnside problem for Bruck loops has a negative answer.

  16. Affective Priming with Auditory Speech Stimuli

    Science.gov (United States)

    Degner, Juliane

    2011-01-01

    Four experiments explored the applicability of auditory stimulus presentation in affective priming tasks. In Experiment 1, it was found that standard affective priming effects occur when prime and target words are presented simultaneously via headphones similar to a dichotic listening procedure. In Experiment 2, stimulus onset asynchrony (SOA) was…

  17. Affective priming with auditory speech stimuli

    NARCIS (Netherlands)

    Degner, J.

    2011-01-01

    Four experiments explored the applicability of auditory stimulus presentation in affective priming tasks. In Experiment 1, it was found that standard affective priming effects occur when prime and target words are presented simultaneously via headphones similar to a dichotic listening procedure. In

  18. Structural Priming and Second Language Learning

    Science.gov (United States)

    Shin, Jeong-Ah; Christianson, Kiel

    2012-01-01

    Structural priming (or syntactic priming) is a speaker's tendency to reuse the same structural pattern as one that was previously encountered (Bock, 1986). This study investigated (a) whether the implicit learning processes involved in long-lag structural priming lead to differential second language (L2) improvement in producing two structural…

  19. Functional and morphological findings in early and advanced stages of HIV infection: A comparison of sup 99m Tc-HMPAO SPECT with CT and MRI studies

    Energy Technology Data Exchange (ETDEWEB)

    Tatsch, K.; Bauer, W.M.; Markl, A.; Kirsch, C.M. (Klinikum Grosshadern, Muenchen (Germany, F.R.). Radiologische Klinik und Poliklinik); Schielke, E.; Einhaeupl, K.M. (Klinikum Grosshadern, Muenchen (Germany, F.R.). Neurologische Klinik)

    1990-12-01

    In fourty patients at early and advanced stages of HIV infection (Water-Reed stages I-VI) regional cerebral blood flow was determined by {sup 99m}Tc-HMPAO SPECT, comparing the results with CT and MRI findings. All patients with HIV encephalopathy (AIDS dementia complex) had pathologic SPECT results (multilocular, patchy uptake defects), but also in earlier and even earliest stages of HIV infection positive SPECT findings were observed. Compared to functional SPECT imaging, morphologically orientated method (CT, MRI) were insensitive in detecting HIV-induced foci: More than 50% of the patients with pathologic SPECT findings had negative CT or MRI scans. Most patients in advanced Walter Reed stages had neurological abnormalities accompanied by positive SPECT. Subtle alterations of HMPAO uptake were observed even in a few cases of early HIV infection without neurological CNS symptoms. The data presented suggest that HMPAO SPECT is highly sensitive in the detection of altered brain perfusion not only in advanced but also early stages of HIV infection. Changes in regional cerebral blood flow are presented before noticeable structural defects may be observed. (orig./MG).

  20. Diophantine Approximation with Two Primes and One Square of Prime

    Institute of Scientific and Technical Information of China (English)

    LI Wei-ping; WANG Tian-ze

    2012-01-01

    We show that if λ1,λ2,λ3 are non-zero real numbers,not all of the same sign,η is real and λ1/λ2 is irrational,then there are infinitely many ordered triples of primes (p1,p2,p3) for which |λ1p1 + λ2p2 + λ3P23 +η| < (maxpj)-1/40 (log maxpj)4.

  1. Tight coupling between positive and reversed priming in the masked prime paradigm

    OpenAIRE

    Boy, Frederic; Sumner, Petroc

    2010-01-01

    When associations between certain visual stimuli and particular actions are learnt, those stimuli become capable of automatically and unconsciously activating their associated action plans. Such sensorimotor priming is assumed to be fundamental for efficient responses, and can be reliably measured in masked prime studies even when the primes are not consciously perceived. However, when the delay between prime and target is increased, reversed priming effects are often found instead (the negat...

  2. Pretreatment performance status and nutrition are associated with early mortality of locally advanced head and neck cancer patients undergoing concurrent chemoradiation.

    Science.gov (United States)

    Chang, Pei-Hung; Yeh, Kun-Yun; Huang, Jen-Seng; Lai, Chien-Hong; Wu, Tsung-Han; Lan, Yii-Jenq; Tsai, Jason Chien-Sheng; Chen, Eric Yen-Chao; Yang, Shih-Wei; Wang, Cheng-Hsu

    2013-05-01

    Unexpected fatal events in patients with head and neck cancers undergoing concurrent chemoradiation therapy are a clinical concern. Malnutrition, which is reported frequently in head and neck cancer patients, are associated with immunity derangement. The purpose of this study was to identify risk factors for early death of patients undergoing chemoradiation. We retrospectively analyzed the records of 194 stage III, IVA, and IVB head and neck cancer patients who were treated with chemoradiation between 2007 and 2009. We defined early death as death while receiving chemoradiation or within 60 days of treatment completion. Risk factors for early death were tested using univariate and multivariate analyses. Fourteen patients (7.2 %) experienced early death, 78.6 % of whom died of infection. Univariate analysis revealed significant correlations between early death and several pretreatment variables, including Eastern Cooperative Oncology Group performance status (PS) >1, hemoglobin total lymphocyte count 1, BMI total lymphocyte count malnutrition before chemoradiation independently predict early death in locally advanced head and neck cancer patients undergoing chemoradiation. Cautious management of head and neck cancer patients with these risk factors is required throughout chemoradiation period.

  3. French Prime Minister tours CERN

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    On 30 July, Jean-Marc Ayrault, the Prime Minister of the French Republic, and Geneviève Fioraso, the Minister of Higher Education and Research, visited the Laboratory.   After being met by the Director-General at LHC Point 5, they visited the CMS control centre and experiment cavern, and got a glimpse of the LHC tunnel at Point 5. The visit ended with a round-table discussion with French and other international members of CERN’s scientific community. During the discussion, the Prime Minister reaffirmed that “support for fundamental research has to be maintained, and France must continue to invest in education, research and innovation.” He also paid tribute to CERN's role in international cooperation, which he qualified as “a fine example of science without borders.”

  4. Controllability, Bezoutian and relative primeness

    Directory of Open Access Journals (Sweden)

    B. N. Datta

    1980-01-01

    Full Text Available Let f(x and g(x be two polynomials of degree n. Then it is well-known that the Bezoutian matrix Bfg associated with f(x and g(x is nonsingular if and only if f(x and g(x are relatively prime. We give an alternative proof of this result. The proof is based on a result on controllability derived in this note.

  5. Affective Priming Caused by Lying

    Directory of Open Access Journals (Sweden)

    Megumi Sato

    2011-10-01

    Full Text Available Typically, arousal increases when telling a lie, as indicated in psychophysiological studies about lie detection. But the emotional valence induced by lying is unknown, though intuition indicates that it may be negative. Indeed, the Electrodermal Activity (EDA, used in such studies, only shows arousal changes during an emotional response. In this study, we examined the emotional valence induced by lying using two tasks. First, in the deceptive task, participants answered “no” to every question regarding the nature of displayed playing cards. Therefore, they told a lie about specific cards. During the task, their EDA was recorded. Secondly, in the figure estimation task, they assessed pictures by “like” or “dislike” after looking at playing cards visibly or subliminally as prime stimuli. We expected them to tend to estimate figures by “dislike” when cards relevant to deception were previously shown. This would mean that an affective priming effect due to telling a lie happened. Actually, this effect was found only when prime stimuli were displayed visibly. This result suggests that lying per se induces negative emotions even without motivation or punishment due to lying. Furthermore, we found that such effect was more blatant in participants whose EDA changes were salient while lying.

  6. KAPAO Prime: Design and Simulation

    Science.gov (United States)

    McGonigle, Lorcan; Choi, P. I.; Severson, S. A.; Spjut, E.

    2013-01-01

    KAPAO (KAPAO A Pomona Adaptive Optics instrument) is a dual-band natural guide star adaptive optics system designed to measure and remove atmospheric aberration over UV-NIR wavelengths from Pomona College’s telescope atop Table Mountain. We present here, the final optical system, KAPAO Prime, designed in Zemax Optical Design Software that uses custom off-axis paraboloid mirrors (OAPs) to manipulate light appropriately for a Shack-Hartman wavefront sensor, deformable mirror, and science cameras. KAPAO Prime is characterized by diffraction limited imaging over the full 81” field of view of our optical camera at f/33 as well as over the smaller field of view of our NIR camera at f/50. In Zemax, tolerances of 1% on OAP focal length and off-axis distance were shown to contribute an additional 4 nm of wavefront error (98% confidence) over the field of view of our optical camera; the contribution from surface irregularity was determined analytically to be 40nm for OAPs specified to λ/10 surface irregularity (632.8nm). Modeling of the temperature deformation of the breadboard in SolidWorks revealed 70 micron contractions along the edges of the board for a decrease of 75°F when applied to OAP positions such displacements from the optimal layout are predicted to contribute an additional 20 nanometers of wavefront error. Flexure modeling of the breadboard due to gravity is on-going. We hope to begin alignment and testing of KAPAO Prime in Q1 2013.

  7. Feasibility of early tapering of cyclosporine following reduced-intensity stem cell transplantation for advanced hematologic or solid malignancies.

    Science.gov (United States)

    Hori, Akiko; Kami, Masahiro; Ohnishi, Mutsuko; Murashige, Naoko; Kojima, Rie; Takaue, Yoichi

    2005-07-01

    Although some researchers have reported that early tapering of cyclosporine is feasible and beneficial to augment graft-versus-leukemia effects after conventional stem-cell transplantation, there is little information on the feasibility of this strategy following reduced-intensity stem cell transplantation (RIST). We summarized outcomes of 17 patients who underwent early tapering of cyclosporine following RIST from HLA-identical siblings.

  8. Advancing the Early Childhood Workforce: Implementation of Training and Retention Initiatives in the Bay Area. Policy Brief 04-1

    Science.gov (United States)

    Johnson, Laura Ruth; Pai, Seeta A.; Bridges, Margaret

    2004-01-01

    Nationwide, public attention has increasingly focused on the need for a variety of early care and education arrangements to meet the changing needs of families. The demand for early care and education has grown for families from all socioeconomic sectors, intensifying as participants in welfare-to-work programs enter the workforce, and as work…

  9. Benefits of Early Versus Delayed Palliative Care to Informal Family Caregivers of Patients With Advanced Cancer: Outcomes From the ENABLE III Randomized Controlled Trial.

    Science.gov (United States)

    Dionne-Odom, J Nicholas; Azuero, Andres; Lyons, Kathleen D; Hull, Jay G; Tosteson, Tor; Li, Zhigang; Li, Zhongze; Frost, Jennifer; Dragnev, Konstantin H; Akyar, Imatullah; Hegel, Mark T; Bakitas, Marie A

    2015-05-01

    To determine the effect of early versus delayed initiation of a palliative care intervention for family caregivers (CGs) of patients with advanced cancer. Between October 2010 and March 2013, CGs of patients with advanced cancer were randomly assigned to receive three structured weekly telephone coaching sessions, monthly follow-up, and a bereavement call either early after enrollment or 3 months later. CGs of patients with advanced cancer were recruited from a National Cancer Institute cancer center, a Veterans Administration Medical Center, and two community outreach clinics. Outcomes were quality of life (QOL), depression, and burden (objective, stress, and demand). A total of 122 CGs (early, n = 61; delayed, n = 61) of 207 patients participated; average age was 60 years, and most were female (78.7%) and white (92.6%). Between-group differences in depression scores from enrollment to 3 months (before delayed group started intervention) favored the early group (mean difference, -3.4; SE, 1.5; d = -.32; P = .02). There were no differences in QOL (mean difference, -2; SE, 2.3; d = -.13; P = .39) or burden (objective: mean difference, 0.3; SE, .7; d = .09; P = .64; stress: mean difference, -.5; SE, .5; d = -.2; P = .29; demand: mean difference, 0; SE, .7; d = -.01; P = .97). In decedents' CGs, a terminal decline analysis indicated between-group differences favoring the early group for depression (mean difference, -3.8; SE, 1.5; d = -.39; P = .02) and stress burden (mean difference, -1.1; SE, .4; d = -.44; P = .01) but not for QOL (mean difference, -4.9; SE, 2.6; d = -.3; P = .07), objective burden (mean difference, -.6; SE, .6; d = -.18; P = .27), or demand burden (mean difference, -.7; SE, .6; d = -.23; P = .22). Early-group CGs had lower depression scores at 3 months and lower depression and stress burden in the terminal decline analysis. Palliative care for CGs should be initiated as early as possible to maximize benefits. © 2015 by American Society of Clinical

  10. Neural mechanisms of uncon-scious visual motion priming

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    The neural correlates of the motion priming were examined in normal young subjects using event-related brain potentials (ERPs) and functional magnetic resonance imaging (fMRI). Visual motion perception can be uncon-sciously biased in favor of a particular direction by a pre-ceding motion in that direction. Motion priming first in-volved an enhancement of ERP amplitude about 100 ms fol-lowing the onset of motion. The amplitudes of ERP compo-nents after 350 ms were also increased. The fMRI results suggest that the early-latency effect reflects modulation of neural responses in extrastriate cortex. Higher-level visual processing areas, including cortical regions MT/MST and the intraparietal cortices were also activated. The findings provide direct evidence that unconscious priming of motion perception is the result of interaction of direction-selective neural responses to motion stimuli. The results cannot be accounted for by refractoriness of neural responses, but in-stead support a theory of motion priming based on motion opponency, as proposed in computational models.

  11. Relational integrativity of prime-target pairs moderates congruity effects in evaluative priming.

    Science.gov (United States)

    Ihmels, Max; Freytag, Peter; Fiedler, Klaus; Alexopoulos, Theodore

    2016-05-01

    In evaluative priming, positive or negative primes facilitate reactions to targets that share the same valence. While this effect is commonly explained as reflecting invariant structures in semantic long-term memory or in the sensorimotor system, the present research highlights the role of integrativity in evaluative priming. Integrativity refers to the ease of integrating two concepts into a new meaningful compound representation. In extended material tests using paired comparisons from two pools of positive and negative words, we show that evaluative congruity is highly correlated with integrativity. Therefore, in most priming studies, congruity and integrativity are strongly confounded. When both aspects are disentangled by manipulating congruity and integrativity orthogonally, three priming experiments show that evaluative-priming effects were confined to integrative prime-target pairs. No facilitation of prime-congruent targets was obtained for non-integrative stimuli. These findings are discussed from a broader perspective on priming conceived as flexible, context-dependent, and serving a generative adaptation function.

  12. Pre-sowing Seed Treatments in Direct-seeded Early Rice: Consequences for Emergence, Seedling Growth and Associated Metabolic Events under Chilling Stress.

    Science.gov (United States)

    Wang, Weiqin; Chen, Qian; Hussain, Saddam; Mei, Junhao; Dong, Huanglin; Peng, Shaobing; Huang, Jianliang; Cui, Kehui; Nie, Lixiao

    2016-01-19

    Double direct-seeding for double rice cropping is a simplified, labor saving, and efficient cropping system to improve multiple-crop index and total rice production in central China. However, poor crop establishment of direct-seeded early rice due to chilling stress is the main obstacle to wide spread of this system. A series of experiments were conducted to unravel the effects of pre-sowing seed treatments on emergence, seedling growth and associated metabolic events of direct-seeded early rice under chilling stress. Two seed priming treatments and two seed coating treatments were used in all the experiments. A non-treated control treatment was also maintained for comparison. In both the field and growth chamber studies, seed priming with selenium or salicylic acid significantly enhanced the emergence and seedling growth of rice compared with non-treated control. Nevertheless, such positive effects were not apparent for seed coating treatments. Better emergence and vigorous seedling growth of rice after seed priming was associated with enhanced α-amylase activity, higher soluble sugars contents, and greater respiration rate in primed rice seedlings under chilling stress. Taking together, these findings may provide new avenues for understanding and advancing priming-induced chilling tolerance in direct-seeded early rice in double rice cropping system.

  13. Advancing family health through the Garden of Eatin': on-site food gardens in early childhood education.

    Science.gov (United States)

    Chaufan, Claudia; Yeh, Jarmin; Sigal, Byron

    2015-04-01

    Nutritional practices develop over the life course. Developing healthy habits at an early age can contribute to combating increasing child obesity rates. Through a range of activities that rely on the presence of an on-site food garden, North Bay Children's Center (NBCC), an early childhood education program, has enacted a "culture of health" into all aspects of the curriculum to promote healthy eating practices among children, families, teachers and staff. NBCC's garden program serves as a model in early childhood education and as a community-based intervention to improve family health and prevent child obesity.

  14. Priming emotional facial expressions as evidenced by event-related brain potentials.

    Science.gov (United States)

    Werheid, Katja; Alpay, Gamze; Jentzsch, Ines; Sommer, Werner

    2005-02-01

    As human faces are important social signals in everyday life, processing of facial affect has recently entered into the focus of neuroscientific research. In the present study, priming of faces showing the same emotional expression was measured with the help of event-related potentials (ERPs) in order to investigate the temporal characteristics of processing facial expressions. Participants classified portraits of unfamiliar persons according to their emotional expression (happy or angry). The portraits were either preceded by the face of a different person expressing the same affect (primed) or the opposite affect (unprimed). ERPs revealed both early and late priming effects, independent of stimulus valence. The early priming effect was characterized by attenuated frontal ERP amplitudes between 100 and 200 ms in response to primed targets. Its dipole sources were localised in the inferior occipitotemporal cortex, possibly related to the detection of expression-specific facial configurations, and in the insular cortex, considered to be involved in affective processes. The late priming effect, an enhancement of the late positive potential (LPP) following unprimed targets, may evidence greater relevance attributed to a change of emotional expressions. Our results (i) point to the view that a change of affect-related facial configuration can be detected very early during face perception and (ii) support previous findings on the amplitude of the late positive potential being rather related to arousal than to the specific valence of an emotional signal.

  15. Positive and negative spatial priming in schizophrenia.

    Science.gov (United States)

    Zimmermann, Mark; Stark, Rudolf; Kern, Georg; Laiacker, Manuela; Kirsch, Peter; Vaitl, Dieter

    2006-07-01

    Priming tasks are used for investigating the deficits of selective attention in schizophrenia, which are thought to be related to the psychotic symptoms. Priming was assessed in acutely psychotic unmedicated (n = 22) and medicated (n = 36) schizophrenia patients and in control subjects (n = 42). The subjects had to indicate the location of a target stimulus in two consecutive stimulus displays (prime and probe). Each stimulus appeared together with a distractor on a screen. Negative Priming is characterized by an increase in reaction time, whenever a probe target is presented at a prime distractor location. Positive Priming is characterized by a decrease in reaction time, when the probe target is presented at the prime target location. Schizophrenia patients altogether showed no abnormalities in priming effects, neither in the acute phase of illness (medicated and unmedicated) nor in partial remission (one month later, medicated). In unmedicated patients however Negative Priming was inversely correlated with the severity of positive symptoms. This indicates a priming deficit in a small subgroup of severely ill patients. The data support the notion that automatic (implicit) mechanisms of learning are unimpaired in schizophrenia patients unless symptoms exceed a certain critical level.

  16. Wrath of God: religious primes and punishment.

    Science.gov (United States)

    McKay, Ryan; Efferson, Charles; Whitehouse, Harvey; Fehr, Ernst

    2011-06-22

    Recent evidence indicates that priming participants with religious concepts promotes prosocial sharing behaviour. In the present study, we investigated whether religious priming also promotes the costly punishment of unfair behaviour. A total of 304 participants played a punishment game. Before the punishment stage began, participants were subliminally primed with religion primes, secular punishment primes or control primes. We found that religious primes strongly increased the costly punishment of unfair behaviours for a subset of our participants--those who had previously donated to a religious organization. We discuss two proximate mechanisms potentially underpinning this effect. The first is a 'supernatural watcher' mechanism, whereby religious participants punish unfair behaviours when primed because they sense that not doing so will enrage or disappoint an observing supernatural agent. The second is a 'behavioural priming' mechanism, whereby religious primes activate cultural norms pertaining to fairness and its enforcement and occasion behaviour consistent with those norms. We conclude that our results are consistent with dual inheritance proposals about religion and cooperation, whereby religions harness the byproducts of genetically inherited cognitive mechanisms in ways that enhance the survival prospects of their adherents.

  17. Microbial stress priming: a meta-analysis.

    Science.gov (United States)

    Andrade-Linares, Diana R; Lehmann, Anika; Rillig, Matthias C

    2016-04-01

    Microbes have to cope with complex and dynamic environments, making it likely that anticipatory responses provide fitness benefits. Mild, previous stressors can prepare microbes (stress priming) to further and potentially damaging stressors (triggering). We here quantitatively summarize the findings from over 250 trials of 34 studies including bacteria and fungi, demonstrating that priming to stress has a beneficial impact on microbial survival. In fact, survival of primed microbes was about 10-fold higher compared with that in non-primed microbes. Categorical moderators related to microbial taxonomy and the kind of stress applied as priming or as triggering revealed significant differences of priming effect size among 14 different microbial species, 6 stress categories and stressor combination. We found that priming by osmotic, physiological and temperature stress had the highest positive effect sizes on microbial response. Cross-protection was evident for physiological, temperature and pH stresses. Microbes are better prepared against triggering by oxidative, temperature and osmotic stress. Our finding of an overall positive mean effect of priming regardless of the microbial system and particular stressor provides unprecedentedly strong evidence of the broad ecological significance of microbial stress priming. These results further suggest that stress priming may be an important factor in shaping microbial communities.

  18. Accelerating Seed Germination and seedling development of Sorghum (Sorghum bicolor L. Moench) through hydro-priming

    Science.gov (United States)

    Dembele, S., Jr.

    2015-12-01

    Mali, a West Africa Sahelian country, is characterized by a strong dependence on rain-fed agriculture and a low adaptive capacity, making it one of the most vulnerable regions to climate change worldwide. Moreover, although with high uncertainties, most climate models used for the region recognize a growing uncertainty in the onset of the rainy season, which demands urgent adaptation measures. Early-season drought limits crops germination, and hence growth, and yield during rainfed depending production as is common now in Mali, West Africa. Crops germination and establishment could be improved by using seed priming, a process that dry seeds take up water to initiate the primary stages of germination, but the amount of water added is not enough for completing germination. The effects of hydro-priming (distilled, tap, rain, river and well water) were evaluated for three priming durations (4, 8 and 12 hour) in 2014 and 2015. Monitored were seed germination and seedling development of nine sorghum genotypes. Preliminary results showed that hydro-priming significantly improved germination rate, germination speed, number of seminal root, rate of survival and seedling vigour index, compared to non-primed seed treatments. However, seedling length, root length, shoot length and seedling dry weight did not differ significantly. Four out of the nine genotypes evaluated were attributed good seed quality and good response to hydro-priming. The priming with different sources of water resulted in higher seed germination (90%) and seedling development with well and river water, compared to the others. Seed germination rate, uniformity and speed were also enhanced by hydro-priming. It is argued that hydro-priming is a simple but effective method for improving seed germination and seedling development of sorghum. In addition hydro-priming is a safe, simple and inexpensive method to enhance germination. The most promising genotypes have consequently been included in consequent pot

  19. A paradox of syntactic priming: Why response tendencies show priming for passives, and response latencies show priming for actives

    OpenAIRE

    Corley, M.; Segaert, K.; Menenti, L.; Weber, K; Hagoort, P.

    2011-01-01

    Speakers tend to repeat syntactic structures across sentences, a phenomenon called syntactic priming. Although it has been suggested that repeating syntactic structures should result in speeded responses, previous research has focused on effects in response tendencies. We investigated syntactic priming effects simultaneously in response tendencies and response latencies for active and passive transitive sentences in a picture description task. In Experiment 1, there were priming effects in re...

  20. A paradox of syntactic priming: Why response tendencies show priming for passives, and response latencies show priming for actives

    OpenAIRE

    Corley, M.; Segaert, K.; Menenti, L.; Weber, K.; Hagoort, P.

    2011-01-01

    Speakers tend to repeat syntactic structures across sentences, a phenomenon called syntactic priming. Although it has been suggested that repeating syntactic structures should result in speeded responses, previous research has focused on effects in response tendencies. We investigated syntactic priming effects simultaneously in response tendencies and response latencies for active and passive transitive sentences in a picture description task. In Experiment 1, there were priming effects in re...

  1. The direction of masked auditory category priming correlates with participants' prime discrimination ability.

    Science.gov (United States)

    Bermeitinger, Christina; Wentura, Dirk; Koppermann, Christopher; Hauser, Micha; Grass, Benjamin; Frings, Christian

    2012-01-01

    Semantic priming refers to the phenomenon that participants typically respond faster to targets following semantically related primes as compared to semantically unrelated primes. In contrast, Wentura and Frings (2005) found a negatively signed priming effect (i.e., faster responses to semantically unrelated as compared to semantically related targets) when they used (a) a special masking technique for the primes and (b) categorically related prime-target-pairs (e.g., fruit-apple). The negatively signed priming effect was most pronounced for participants with random prime discrimination performance, whereas participants with high prime discrimination performance showed a positive effect. In the present study we analyzed the after-effects of masked category primes in audition. A comparable pattern of results as in the visual modality emerged: The poorer the individual prime discrimination, the more negative is the semantic priming effect. This result is interpreted as evidence for a common mechanism causing the semantic priming effect in vision as well as in audition instead of a perceptual mechanism only working in the visual domain.

  2. First observation of the M1 transition $\\psi^\\prime\\to \\gamma\\eta_c^\\prime$

    CERN Document Server

    Ablikim, M; Ambrose, D J; An, F F; An, Q; An, Z H; Bai, J Z; Ban, Y; Becker, J; Berger, N; Bertani, M; Bian, J M; Boger, E; Bondarenko, O; Boyko, I; Briere, R A; Bytev, V; Cai, X; Calcaterra, A; Cao, G F; Chang, J F; Chelkov, G; Chen, G; Chen, H S; Chen, J C; Chen, M L; Chen, S J; Chen, Y; Chen, Y B; Cheng, H P; Chu, Y P; Cronin-Hennessy, D; Dai, H L; Dai, J P; Dedovich, D; Deng, Z Y; Denig, A; Denysenko, I; Destefanis, M; Ding, W M; Ding, Y; Dong, L Y; Dong, M Y; Du, S X; Fang, J; Fang, S S; Fava, L; Feldbauer, F; Feng, C Q; Ferroli, R B; Fu, C D; Fu, J L; Gao, Y; Geng, C; Goetzen, K; Gong, W X; Gradl, W; Greco, M; Gu, M H; Gu, Y T; Guan, Y H; Guo, A Q; Guo, L B; Guo, Y P; Han, Y L; Hao, X Q; Harris, F A; He, K L; He, M; He, Z Y; Held, T; Heng, Y K; Hou, Z L; Hu, H M; Hu, J F; Hu, T; Huang, B; Huang, G M; Huang, J S; Huang, X T; Huang, Y P; Hussain, T; Ji, C S; Ji, Q; Ji, X B; Ji, X L; Jia, L K; Jiang, L L; Jiang, X S; Jiao, J B; Jiao, Z; Jin, D P; Jin, S; Jing, F F; Kalantar-Nayestanaki, N; Kavatsyuk, M; Kuehn, W; Lai, W; Lange, J S; Leung, J K C; Li, C H; Li, Cheng; Li, Cui; Li, D M; Li, F; Li, G; Li, H B; Li, J C; Li, K; Li, Lei; Li, N B; Li, Q J; Li, S L; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Li, X R; Li, Z B; Liang, H; Liang, Y F; Liang, Y T; Liao, G R; Liao, X T; Liu, B J; Liu, B J; Liu, C L; Liu, C X; Liu, C Y; Liu, F H; Liu, Fang; Liu, Feng; Liu, H; Liu, H B; Liu, H H; Liu, H M; Liu, H W; Liu, J P; Liu, K Y; Liu, Kai; Liu, Kun; Liu, P L; Liu, S B; Liu, X; Liu, X H; Liu, Y; Liu, Y B; Liu, Z A; Liu, Zhiqiang; Liu, Zhiqing; Loehner, H; Lu, G R; Lu, H J; Lu, J G; Lu, Q W; Lu, X R; Lu, Y P; Luo, C L; Luo, M X; Luo, T; Luo, X L; Lv, M; Ma, C L; Ma, F C; Ma, H L; Ma, Q M; Ma, S; Ma, T; Ma, X Y; Ma, Y; Maas, F E; Maggiora, M; Malik, Q A; Mao, H; Mao, Y J; Mao, Z P; Messchendorp, J G; Min, J; Min, T J; Mitchell, R E; Mo, X H; Morales, C Morales; Motzko, C; Muchnoi, N Yu; Nefedov, Y; Nicholson, C; Nikolaev, I B; Ning, Z; Olsen, S L; Ouyang, Q; Pacetti, S; Park, J W; Pelizaeus, M; Peng, H P; Peters, K; Ping, J L; Ping, R G; Poling, R; Prencipe, E; Pun, C S J; Qi, M; Qian, S; Qiao, C F; Qin, X S; Qin, Y; Qin, Z H; Qiu, J F; Rashid, K H; Rong, G; Ruan, X D; Sarantsev, A; Schaefer, B D; Schulze, J; Shao, M; Shen, C P; Shen, X Y; Sheng, H Y; Shepherd, M R; Song, X Y; Spataro, S; Spruck, B; Sun, D H; Sun, G X; Sun, J F; Sun, S S; Sun, X D; Sun, Y J; Sun, Y Z; Sun, Z J; Sun, Z T; Tang, C J; Tang, X; Thorndike, E H; Tian, H L; Toth, D; Ullrich, M; Varner, G S; Wang, B; Wang, B Q; Wang, K; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, Q; Wang, Q J; Wang, S G; Wang, X F; Wang, X L; Wang, Y D; Wang, Y F; Wang, Y Q; Wang, Z; Wang, Z G; Wang, Z Y; Wei, D H; Weidenkaff, P; Wen, Q G; Wen, S P; Werner, M; Wiedner, U; Wu, L H; Wu, N; Wu, S X; Wu, W; Wu, Z; Xia, L G; Xiao, Z J; Xie, Y G; Xiu, Q L; Xu, G F; Xu, G M; Xu, H; Xu, Q J; Xu, X P; Xu, Y; Xu, Z R; Xue, F; Xue, Z; Yan, L; Yan, W B; Yan, Y H; Yang, H X; Yang, T; Yang, Y; Yang, Y X; Ye, H; Ye, M; Ye, M H; Yu, B X; Yu, C X; Yu, J S; Yu, L; Yu, S P; Yuan, C Z; Yuan, W L; Yuan, Y; Zafar, A A; Zallo, A; Zeng, Y; Zhang, B X; Zhang, B Y; Zhang, C C; Zhang, D H; Zhang, H H; Zhang, H Y; Zhang, J; Zhang, J G; Zhang, J Q; Zhang, J W; Zhang, J Y; Zhang, J Z; Zhang, L; Zhang, S H; Zhang, T R; Zhang, X J; Zhang, X Y; Zhang, Y; Zhang, Y H; Zhang, Y S; Zhang, Z P; Zhang, Z Y; Zhao, G; Zhao, H S; Zhao, J W; Zhao, K X; Zhao, Lei; Zhao, Ling; Zhao, M G; Zhao, Q; Zhao, S J; Zhao, T C; Zhao, X H; Zhao, Y B; Zhao, Z G; Zhemchugov, A; Zheng, B; Zheng, J P; Zheng, Y H; Zheng, Z P; Zhong, B; Zhong, J; Zhou, L; Zhou, X K; Zhou, X R; Zhu, C; Zhu, K; Zhu, K J; Zhu, S H; Zhu, X L; Zhu, X W; Zhu, Y M; Zhu, Y S; Zhu, Z A; Zhuang, J; Zou, B S; Zou, J H; Zuo, J X

    2012-01-01

    Using a sample of 106 million $\\psi^\\prime$ events collected with the BESIII detector at the BEPCII storage ring, we have made the first measurement of the M1 transition between the radially excited charmonium $S$-wave spin-triplet and the radially excited $S$-wave spin-singlet states: $\\psi^\\prime\\to\\gamma\\eta_c^\\prime$. Analyses of the processes $\\psi^\\prime\\to \\gamma\\eta_c^\\prime$ with $\\eta_c^\\prime\\to \\K_S^0 K\\pi$ and $K^+K^-\\pi^0$ gave an $\\eta_c^\\prime$ signal with a statistical significance of greater than 10 standard deviations under a wide range of assumptions about the signal and background properties. The data are used to obtain measurements of the $\\eta_c^\\prime$ mass ($M(\\eta_c^\\prime)=3637.6\\pm 2.9_\\mathrm{stat}\\pm 1.6_\\mathrm{sys}$ MeV/$c^2$), width ($\\Gamma(\\eta_c^\\prime)=16.9\\pm 6.4_\\mathrm{stat}\\pm 4.8_\\mathrm{sys}$ MeV), and the product branching fraction ($\\BR(\\psi^\\prime\\to \\gamma\\eta_c^\\prime)\\times \\BR(\\eta_c^\\prime\\to K\\bar K\\pi) = (1.30\\pm 0.20_\\mathrm{stat}\\pm 0.30_\\mathrm{sys})\\tim...

  3. Auditory morphological processing: Evidence from phonological priming.

    Science.gov (United States)

    Bacovcin, Hezekiah Akiva; Goodwin Davies, Amy; Wilder, Robert J; Embick, David

    2017-07-01

    Using an auditory lexical decision task, we find evidence of a facilitatory priming effect for morphologically complex targets (e.g., snow-ed) preceded by primes which rhyme with the target's stem (e.g., dough). By using rhyme priming, we are able to probe for morphological processing in a way that avoids confounds arising from semantic relatedness that are inherent to morphological priming (snow/snow-ed). Phonological control conditions (e.g., targets code and grove for prime dough) are used to rule out alternative interpretations of the effect that are based on partial rhyme or phonological embedding of the stem. The findings provide novel evidence for an independent morphological component in lexical processing and demonstrate the utility of rhyme priming in probing morphological representation. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Multiple Phenotypic Changes Define Neutrophil Priming

    Science.gov (United States)

    Miralda, Irina; Uriarte, Silvia M.; McLeish, Kenneth R.

    2017-01-01

    Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial and viral products induces neutrophils to transition from a basal state into a primed one, which is currently defined as an enhanced response to activating stimuli. Although, typically associated with enhanced generation of reactive oxygen species (ROS) by the NADPH oxidase, primed neutrophils show enhanced responsiveness of exocytosis, NET formation, and chemotaxis. Phenotypic changes associated with priming also include activation of a subset of functions, including adhesion, transcription, metabolism, and rate of apoptosis. This review summarizes the breadth of phenotypic changes associated with priming and reviews current knowledge of the molecular mechanisms behind those changes. We conclude that the current definition of priming is too restrictive. Priming represents a combination of enhanced responsiveness and activated functions that regulate both adaptive and innate immune responses. PMID:28611952

  5. Prime focus spectrograph: Subaru's future

    OpenAIRE

    Sugai, Hajime; Dekany, Richard G.; Ellis, Richard S.; Seiffert, Michael D.; Smith, Roger M.

    2012-01-01

    The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru’s wide field of view, which is further extended with the recently completed Wide Fie...

  6. Can religious priming induce truthful preference revelation?

    OpenAIRE

    Stachtiaris, Spiros; Drichoutis, Andreas; Nayga, Rodolfo; Klonaris, Stathis

    2011-01-01

    We examine whether religious priming can induce more truthful preference revelation in valuation research. Using induced value second price Vickrey auctions in both hypothetical and non-hypothetical contexts, our results suggest that religious priming can indeed induce more truthful bidding and eliminate hypothetical bias in hypothetical contexts. In non-hypothetical contexts where there are real economic incentives, religious priming induces similar truthful bidding as the absence of religio...

  7. Radiotherapy and chemotherapy in locally advanced non-small cell lung cancer: preclinical and early clinical data.

    Science.gov (United States)

    Reboul, François L

    2004-02-01

    Over the past 20 years, combined treatment with radiotherapy and second-generation chemotherapy drugs was extensively studied in patients with locally advanced NSCLC and became the standard over radiotherapy alone in patients with good performance status. Radiosensitizing properties of cisplatin have been identified in the laboratory. Close temporal administration of cisplatin and radiation is mandatory for enhanced antitumor efficacy, but results in significant toxicity to normal tissues. Early clinical studies demonstrated that the concurrent administration of cisplatin during STD-RT was feasible, with acceptable esophageal toxicity, and had the potential of significantly improving locoregional control. Carboplatin administered concurrently with accelerated HFX-RT was responsible for a higher rate of esophageal toxicity. Further improvement in survival also requires an effective treatment of micro-metastatic disease through full-dose delivery of cytotoxic drugs and the addition of at least one more active drug in conjunction with cisplatin and radiotherapy to further improve locoregional control of the disease. In most clinical studies, etoposide was the second drug of choice because of its own radiosensitizing properties and possible synergy with cisplatin. In numerous phase II studies, concurrent radiotherapy and PE resulted in reproducible results in terms of local control (30%-40%), median survival (15-18 months), survival at 2 years (35%-40%), and survival at 5 years (25%-30%). In phase III studies, these results were shown to be superior to radiotherapy alone and to induction chemotherapy followed by STD-RT. The question of the potential benefit of HFX-RT combined with PE has been addressed in phase II and III studies. At this time, there is no firm evidence that concurrent chemotherapy with HFX-RT is superior to concurrent chemotherapy with STD-RT in terms of local control and survival. Only a significant benefit in terms of local control or survival would

  8. Complex architecture of primes and natural numbers.

    Science.gov (United States)

    García-Pérez, Guillermo; Serrano, M Ángeles; Boguñá, Marián

    2014-08-01

    Natural numbers can be divided in two nonoverlapping infinite sets, primes and composites, with composites factorizing into primes. Despite their apparent simplicity, the elucidation of the architecture of natural numbers with primes as building blocks remains elusive. Here, we propose a new approach to decoding the architecture of natural numbers based on complex networks and stochastic processes theory. We introduce a parameter-free non-Markovian dynamical model that naturally generates random primes and their relation with composite numbers with remarkable accuracy. Our model satisfies the prime number theorem as an emerging property and a refined version of Cramér's conjecture about the statistics of gaps between consecutive primes that seems closer to reality than the original Cramér's version. Regarding composites, the model helps us to derive the prime factors counting function, giving the probability of distinct prime factors for any integer. Probabilistic models like ours can help to get deeper insights about primes and the complex architecture of natural numbers.

  9. Affective priming of emotional pictures in parafoveal vision: left visual field advantage.

    Science.gov (United States)

    Calvo, Manuel G; Avero, Pedro

    2008-03-01

    This study investigated whether stimulus affective content can be extracted from visual scenes when these appear in parafoveal locations of the visual field and are foveally masked, and whether there is lateralization involved. Parafoveal prime pleasant or unpleasant scenes were presented for 150 msec 2.5 degrees away from fixation and were followed by a foveal probe scene that was either congruent or incongruent in emotional valence with the prime. Participants responded whether the probe was emotionally positive or negative. Affective priming was demonstrated by shorter response latencies for congruent than for incongruent prime-probe pairs. This effect occurred when the prime was presented in the left visual field at a 300-msec prime-probe stimulus onset asynchrony, even when the prime and the probe were different in physical appearance and semantic category. This result reveals that the affective significance of emotional stimuli can be assessed early through covert attention mechanisms, in the absence of overt eye fixations on the stimuli, and suggests that right-hemisphere dominance is involved.

  10. Drought priming at vegetative growth stage enhances nitrogen-use efficiency under post-anthesis drought and heat stress in wheat

    DEFF Research Database (Denmark)

    Liu, S.; Li, Xiangnan; Larsen, Dorthe Horn

    2017-01-01

    To study the effects of early drought priming at 5th-leaf stage on grain yield and nitrogen-use efficiency in wheat (Triticum aestivum L.) under post-anthesis drought and heat stress, wheat plants were first exposed to moderate drought stress (drought priming; that is, the leaf water potential...... reached ca. −0.9 MPa) at the 5th-leaf stage for 11 days, and leaf water relations and gas exchange rates, grain yield and yield components, and agronomic nitrogen-use efficiency (ANUE) of the primed and non-primed plants under post-anthesis drought and heat stress were investigated. Compared with the non-primed...... plants, the drought-primed plants possessed higher leaf water potential and chlorophyll content, and consequently a higher photosynthetic rate during post-anthesis drought and heat stress. Drought priming also resulted in higher grain yield and ANUE in wheat under post-anthesis drought and heat stress...

  11. Cost-effectiveness of early-initiated treatment for advanced-stage epithelial ovarian cancer patients: a modeling study

    NARCIS (Netherlands)

    Hoyer, T.; Bekkers, R.L.; Gooszen, H.G.; Massuger, L.F.A.G.; Rovers, M.M.; Grutters, J.P.C.

    2014-01-01

    OBJECTIVE: Between diagnosis and primary treatment of patients with epithelial ovarian cancer (EOC), gaps of several weeks exist. Reducing these time intervals may benefit the patient and may lead to a reduction of costs. We explored the cost-effectiveness of early-initiated treatment of patients wi

  12. 早期口腔癌检查及诊断方法的研究进展%Advances in detection and diagnosis of early oral cancers

    Institute of Scientific and Technical Information of China (English)

    李金忠; 李鑫; 郑家伟

    2012-01-01

    过去几十年,口腔癌的治疗方法取得了很大进步,但中晚期口腔癌的预后并未碍到明显改善,早期诊断、早期治疗仍然是提高治愈率的关键措施.早期确诊的主要方法是切取活检,但该方法有创,且异常增生与早期口腔癌的区分过于依赖病理医师的临床经验.为诊断口腔异常增生和早期口腔癌,迫切需要可在门诊条件下操作简便、实用且无创的诊断工具.目前发展迅速的早期口腔癌检测方法包括光学系统检查、活组织染色、唾液检测、刷取活检、DNA分析等.本文对这些方法诊断口腔鳞癌及癌前病损的价值进行回顾与评价.%The therapeutic modalities have accomplished important advances in last several decades, while the prognosis of oral cancers remains unchanged. Since oral cancers have a much better prognosis in early stage than in advanced stage, the detection and diagnosis of early oral cancers is the key in the overall control of oral cancers. The essential method in identification of early cancers is still scalpel biopsy. However, this method is invasive and restricted to highly suspicious lesions. Furthermore, scalpel biopsy depends heavily on the experiences of pathologists in the differential diagnosis of dysplasia and early oral cancers. There is urgent need to devise easy, practical, and non-invasive methods for the detection and diagnosis of early oral cancers that can be performed easily in out-patient set-up. This paper reviewed the current methods, including light-based oral cancer screening system, vital staining, saliva testing, brush biopsy, DNA diploidy analysis, et al, and evaluated them in the detection and diagnosis of early oral cancers and precancerous lesions.

  13. Tight Coupling between Positive and Reversed Priming in the Masked Prime Paradigm

    Science.gov (United States)

    Boy, Frederic; Sumner, Petroc

    2010-01-01

    When associations between certain visual stimuli and particular actions are learned, those stimuli become capable of automatically and unconsciously activating their associated action plans. Such sensorimotor priming is assumed to be fundamental for efficient responses, and can be reliably measured in masked prime studies even when the primes are…

  14. The Effect of Prime Duration in Masked Orthographic Priming Depends on Neighborhood Distribution

    Science.gov (United States)

    Robert, Christelle; Mathey, Stephanie

    2012-01-01

    A lexical decision task was used with a masked priming procedure to investigate whether and to what extent neighborhood distribution influences the effect of prime duration in masked orthographic priming. French word targets had two higher frequency neighbors that were either distributed over two letter positions (e.g., "LOBE/robe-loge")…

  15. Priming effects on the N400 in the affective priming paradigm with facial expressions of emotion.

    Science.gov (United States)

    Aguado, Luis; Dieguez-Risco, Teresa; Méndez-Bértolo, Constantino; Pozo, Miguel A; Hinojosa, José A

    2013-06-01

    We studied the effect of facial expression primes on the evaluation of target words through a variant of the affective priming paradigm. In order to make the affective valence of the faces irrelevant to the task, the participants were assigned a double prime-target task in which they were unpredictably asked either to identify the gender of the face or to evaluate whether the word was pleasant or unpleasant. Behavioral and electrophysiological (event-related potential, or ERP) indices of affective priming were analyzed. Temporal and spatial versions of principal components analyses were used to detect and quantify those ERP components associated with affective priming. Although no significant behavioral priming was observed, electrophysiological indices showed a reverse priming effect, in the sense that the amplitude of the N400 was higher in response to congruent than to incongruent negative words. Moreover, a late positive potential (LPP), peaking around 700 ms, was sensitive to affective valence but not to prime-target congruency. This pattern of results is consistent with previous accounts of ERP effects in the affective priming paradigm that have linked the LPP with evaluative priming and the N400 with semantic priming. Our proposed explanation of the N400 priming effects obtained in the present study is based on two assumptions: a double check of affective stimuli in terms of valence and specific emotion content, and the differential specificities of facial expressions of positive and negative emotions.

  16. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes.

    Directory of Open Access Journals (Sweden)

    Bruce A Perkins

    Full Text Available OBJECTIVE: To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in microalbuminuria onset or subsequent decline of glomerular filtration rate (termed "early GFR decline" in patients with type 1 diabetes. METHODS: From the 1(st Joslin Kidney Study, we selected 30 patients with longstanding normoalbuminuria and 55 patients with new onset microalbuminuria. Patients with microalbuminuria had 8-12 years follow-up during which 33 had stable GFR and 22 early GFR decline. Mean baseline GFR(CYSTATIN C was similar between the three groups. Glycation, oxidation and nitration markers were measured in protein and ultrafiltrate at baseline by liquid chromatography-tandem mass spectrometry using the most reliable methods currently available. RESULTS: Though none were significantly different between patients with microalbuminuria with stable or early GFR decline, levels of 6 protein damage adduct residues of plasma protein and 4 related free adducts of plasma ultrafiltrate were significantly different in patients with microalbuminuria compared to normoalbuminuria controls. Three protein damage adduct residues were decreased and 3 increased in microalbuminuria while 3 free adducts were decreased and one increased in microalbuminuria. The most profound differences were of N-formylkynurenine (NFK protein adduct residue and N(ω-carboxymethylarginine (CMA free adduct in which levels were markedly lower in microalbuminuria (P<0.001 for both. CONCLUSIONS: Complex processes influence levels of plasma protein damage and related proteolysis product free adducts in type 1 diabetes and microalbuminuria. The effects observed point to the possibility that patients who have efficient mechanisms of disposal of damaged proteins might be at an increased risk of developing microalbuminuria but not early renal function decline. The findings support the concept that the mechanisms responsible for microalbuminuria may differ from the

  17. The effect of stereotypical primes on the neural processing of racially ambiguous faces.

    Science.gov (United States)

    Dickter, Cheryl L; Kittel, Julie A

    2012-01-01

    Previous research has demonstrated that an early attentional component of the event-related potential (ERP), the P2, is sensitive to the distinction between the processing of racial outgroup and ingroup faces but may not be sensitive to the distinction between racially ambiguous and ingroup faces. Recent behavioral work, however, has suggested that contextual information may affect the processing of racially ambiguous faces. Thus, the first goal of this study was to examine whether the early neural processing of racially ambiguous faces would be affected by primed stereotypes. White college student participants (n = 29) completed a task in which they racially categorized monoracial Black and White faces and racially ambiguous Black-White morphs. These faces were preceded by positive and negative Black and White stereotypical primes. Results indicated that P2 amplitude to the racially ambiguous faces was moderated by the valence of the primes such that negative primes led to greater neural processing of the racially ambiguous faces than positive primes. Furthermore, the extent to which P2 amplitude was affected by prime valence was moderated by individual differences in preference for structure and categorical thinking, as well as comfort with ambiguity.

  18. Visibility predicts priming within but not between people: a cautionary tale for studies of cognitive individual differences.

    Science.gov (United States)

    Boy, Frederic; Sumner, Petroc

    2014-06-01

    With resurgent interest in individual differences in perception, cognition and behavioral control as early indicators of disease, endophenotypes, or a means to relate brain structure to function, behavioral tasks are increasingly being transferred from within-subject settings to between-group or correlational designs. The assumption is that where we know the mechanisms underlying within-subject effects, these effects can be used to measure individual differences in those same mechanisms. However, between-subjects variability can arise from an entirely different source from that driving within-subject effects, and here we report a clear-cut demonstration of this. We examined the debated relationship between the visibility of a masked-prime stimulus and the direction of priming it causes (positive or reversed). Such reversal of priming has been hypothesized to reflect an automatic inhibitory mechanism that controls partially activated responses and allows behavioral flexibility. Within subjects, we found an unambiguous systematic transition from reversed priming to positive priming as prime visibility increased, replicated 7 times, and using different stimulus manipulations. However, across individuals there was never a relationship between prime discrimination ability and priming. Specifically, these data resolve the controversial debate on visibility and reversed priming, indicating that they arise from independent processes relying on partially shared stimulus signals. More generally, they stand as an exemplar case in which variance between individuals arises from a different source from that produced by stimulus manipulations.

  19. Inverse Target- and Cue-Priming Effects of Masked Stimuli

    Science.gov (United States)

    Mattler, Uwe

    2007-01-01

    The processing of a visual target that follows a briefly presented prime stimulus can be facilitated if prime and target stimuli are similar. In contrast to these positive priming effects, inverse priming effects (or negative compatibility effects) have been found when a mask follows prime stimuli before the target stimulus is presented: Responses…

  20. Priming the Secure Attachment Schema Affects the Emotional Face Processing Bias in Attachment Anxiety: An fMRI Research.

    Science.gov (United States)

    Tang, Qingting; Chen, Xu; Hu, Jia; Liu, Ying

    2017-01-01

    Our study explored how priming with a secure base schema affects the processing of emotional facial stimuli in individuals with attachment anxiety. We enrolled 42 undergraduate students between 18 and 27 years of age, and divided them into two groups: attachment anxiety and attachment secure. All participants were primed under two conditions, the secure priming using references to the partner, and neutral priming using neutral references. We performed repeated attachment security priming combined with a dual-task paradigm and functional magnetic resonance imaging. Participants' reaction times in terms of responding to the facial stimuli were also measured. Attachment security priming can facilitate an individual's processing of positive emotional faces; for instance, the presentation of the partner's name was associated with stronger activities in a wide range of brain regions and faster reaction times for positive facial expressions in the subjects. The current finding of higher activity in the left-hemisphere regions for secure priming rather than neutral priming is consistent with the prediction that attachment security priming triggers the spread of the activation of a positive emotional state. However, the difference in brain activity during processing of both, positive and negative emotional facial stimuli between the two priming conditions appeared in the attachment anxiety group alone. This study indicates that the effect of attachment secure priming on the processing of emotional facial stimuli could be mediated by chronic attachment anxiety. In addition, it highlights the association between higher-order processes of the attachment system (secure attachment schema priming) and early-stage information processing system (attention), given the increased attention toward the effects of secure base schema on the processing of emotion- and attachment-related information among the insecure population. Thus, the following study has applications in providing

  1. One version of direct response priming requires automatization of the relevant associations but not awareness of the prime.

    Science.gov (United States)

    Klapp, Stuart T

    2015-07-01

    Priming is the influence of one event on performance during a second event. One type of priming is known as semantic priming because it biases interpretation of the subsequent stimulus. Another type, direct response priming, biases responding directly without semantic mediation. Research reviewed in this article indicates that two versions of the second type, direct response priming, can be distinguished. One version, explicit priming, requires awareness of the prime. The other version, associative response priming, occurs even if the prime is masked and not phenomenally visible. This version, which is attributed to associations relating specific sensory events to movements of particular muscles, is enabled only if the association has previously been automatized by brief practice in which the to-be-primed response is made to the stimulus that subsequently appears as the prime. Associative response priming can be explained by a simple stimulus-response interpretation; other varieties of priming are more theoretically challenging. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Early diffusion weighted magnetic resonance imaging can predict survival in women with locally advanced cancer of the cervix treated with combined chemo-radiation

    Energy Technology Data Exchange (ETDEWEB)

    Somoye, Gbolahan; Parkin, David [Ward 42, Aberdeen Royal Infirmary, Aberdeen (United Kingdom); Harry, Vanessa [Royal Marsden NHS Foundation Trust, London (United Kingdom); Semple, Scott [Queen' s Medical Research Institute, Centre for Cardiovascular Science, Clinical Research Imaging Centre, Edinburgh (United Kingdom); Plataniotis, George [Musgrove Park Hospital, Taunton and Somerset NHS Foundation, Taunton (United Kingdom); Scott, Neil [University of Aberdeen, Section of Population Health, Aberdeen (United Kingdom); Gilbert, Fiona J. [University of Cambridge, Radiology Department, Box 218, Cambridge (United Kingdom)

    2012-11-15

    To assess the predictive value of diffusion weighted imaging (DWI) for survival in women treated for advanced cancer of the cervix with concurrent chemo-radiotherapy. Twenty women treated for advanced cancer of the cervix were recruited and followed up for a median of 26 (range <1 to 43) months. They each had DWI performed before treatment, 2 weeks after beginning therapy (midtreatment) and at the end of treatment. Apparent diffusion coefficient (ADC) values were calculated from regions of interest (ROI). All participants were reviewed for follow-up data. ADC values were compared with mortality status (Mann-Whitney test). Time to progression and overall survival were assessed (Kaplan-Meier survival graphs). There were 14 survivors. The median midtreatment ADC was statistically significantly higher in those alive compared to the non-survivors, 1.55 and 1.36 (x 10{sup -3}/mm{sup 2}/s), respectively, P = 0.02. The median change in ADC 14 days after treatment commencement was significantly higher in the alive group compared to non-survivors, 0.28 and 0.14 (x 10{sup -3}/mm{sup 2}/s), respectively, P = 0.02. There was no evidence of a difference between survivors and non-survivors for pretreatment baseline or post-therapy ADC values. Functional DWI early in the treatment of advanced cancer of the cervix may provide useful information in predicting survival. (orig.)

  3. Comparative LC-MS/MS profiling of free and protein-bound early and advanced glycation-induced lysine modifications in dairy products.

    Science.gov (United States)

    Hegele, Jörg; Buetler, Timo; Delatour, Thierry

    2008-06-01

    Free and protein-bound forms of early and advanced glycation-induced lysine (Lys) modifications were quantified in dairy products by LC-MS/MS using a stable isotope dilution assay. The glycation profiles for N(epsilon)-fructoselysine (FL), N(epsilon)-carboxymethyllysine (CML) and pyrraline (Pyr) were monitored in raw and processed cow milk to investigate whether free glycation products could serve as fast and simple markers to assess the extent of protein glycation in dairy products. In all milk samples, the fraction of free glycation adducts was predominantly composed of advanced modifications, e.g. 8.34+/-3.81 nmol CML per micromol of free Lys (Lys(free)) and 81.5+/-87.8 nmol Pyr micromol(-1) Lys(free)(-1) vs. 3.72+/-1.29 nmol FL micromol(-1) Lys(free)(-1). In contrast, the protein-bound early glycation product FL considerably outweighed the content of CML and Pyr in milk proteins of raw and processed cow milk, whereas severely heat treated milk products, e.g. condensed milk, contained a higher amount of protein-bound advanced glycation adducts. Typical values recorded for milk samples processed under mild conditions were 0.47+/-0.08 nmol FL micromol(-1) of protein-bound Lys (Lys(p-b)), 0.04+/-0.03 nmol CML micromol(-1) Lys(p-b)(-1) and 0.06+/-0.02 nmol Pyr micromol(-1)Lys(p-b)(-1). It was particularly noticeable, however, that mild heat treatment of raw milk, i.e. pasteurization and UHT treatment, did not significantly increase the amount of both free and protein-bound Lys modifications. In conclusion, the profiles of free and protein-bound glycation-induced Lys modifications were found to be different and a screening of free glycation adducts does, therefore, not allow for a conclusion about the protein glycation status of dairy products.

  4. Prediction of Response to Immune Checkpoint Inhibitor Therapy Using Early-Time-Point (18)F-FDG PET/CT Imaging in Patients with Advanced Melanoma.

    Science.gov (United States)

    Cho, Steve Y; Lipson, Evan J; Im, Hyung-Jun; Rowe, Steven P; Gonzalez, Esther Mena; Blackford, Amanda; Chirindel, Alin; Pardoll, Drew M; Topalian, Suzanne L; Wahl, Richard L

    2017-09-01

    The purpose of this study was to evaluate (18)F-FDG PET/CT scanning as an early predictor of response to immune checkpoint inhibitors (ICIs) in patients with advanced melanoma. Methods: Twenty patients with advanced melanoma receiving ICI prospectively underwent (18)F-FDG PET/CT at 3 scan intervals: before treatment initiation (SCAN-1), at days 21-28 (SCAN-2), and at 4 mo (SCAN-3). This study was approved by the institutional review board, and informed consent was received from all patients who were enrolled between April 2012 and December 2013. Tumor response at each posttreatment time point was assessed according to RECIST 1.1, immune-related response criteria, PERCIST (PERCIST 1.0), and European Organization for Research and Treatment of Cancer (EORTC) criteria. Performance characteristics of each metric to predict best overall response (BOR) at ≥ 4 mo were assessed. Results: Twenty evaluable patients were treated with ipilimumab (n = 16), BMS-936559 (n = 3), or nivolumab (n = 1). BOR at ≥ 4 mo included complete response (n = 2), partial response (n = 2), stable disease (n = 1), and progressive disease (n = 15). Response evaluations at SCAN-2 using RECIST 1.1, immune-related response criteria, PERCIST, and EORTC criteria demonstrated accuracies of 75%, 70%, 70%, and 65%, respectively, to predict BOR at ≥ 4 mo. Interestingly, the optimal PERCIST and EORTC threshold values at SCAN-2 to predict BOR were >15.5% and >14.7%, respectively. By combining anatomic and functional imaging data collected at SCAN-2, we developed criteria to predict eventual response to ICI with 100% sensitivity, 93% specificity, and 95% accuracy. Conclusion: Combining functional and anatomic imaging parameters from (18)F-FDG PET/CT scans performed early in ICI appears predictive for eventual response in patients with advanced melanoma. These findings require validation in larger cohorts. © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

  5. P11: 18FDG-PET/CT for early prediction of response to first line platinum chemotherapy in advanced thymic epithelial tumors

    Science.gov (United States)

    Palmieri, Giovannella; Ottaviano, Margaret; Del Vecchio, Silvana; Segreto, Sabrina; Tucci, Irene; Damiano, Vincenzo

    2015-01-01

    Background To investigate the value of the metabolic tumor response assessed with 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), compared with clinicobiological markers, to predict the response disease to first line platinum based chemotherapy in advanced thymic epithelial tumors (TETs). Methods Twenty patients with diagnosis of TET and stage of disease III and IV sec, Masaoka-Koga, were retrospectively included in this monocentric study. Different pre-treatment clinical, biological and pathological parameters, including histotype sec, WHO 2004 and stage of disease sec, Masaoka-Koga were assessed. Tumor glucose metabolism at baseline and its change after the first line platinum based chemotherapy (from 4 to 6 cycles) were assessed using FDG-PET, moreover the response disease was assessed using total body CT scan for the evaluation of RECIST criteria 1.1. Results Twelve patients had an objective response to the first line platinum based chemotherapy according RECIST criteria 1.1 and all of them started with a SUVmax at baseline major than 5, indeed the other eight patients, non-responders to chemotherapy, had a SUVmax at baseline minor than 5. Conclusions It is important to define the chemosensitivity of advanced TETs early. Combining bio-pathological parameters with the metabolism at baseline assessed with FDG-PET can help the physician to early predict the probability of obtaining a disease response to first line platinum based chemotherapy. The SUVmax cut off of 5 at 18FDG-PET/CT performed at baseline treatment might be a new parameter for choosing the most powerful first line of chemotherapy. Given these results, further prospective studies are needed to establish a new first line therapy in advanced TETs with a low SUVmax at baseline, non-responders to conventional chemotherapy.

  6. Extending parent-child interaction therapy for early childhood internalizing problems: new advances for an overlooked population.

    Science.gov (United States)

    Carpenter, Aubrey L; Puliafico, Anthony C; Kurtz, Steven M S; Pincus, Donna B; Comer, Jonathan S

    2014-12-01

    Although efficacious psychological treatments for internalizing disorders are now well established for school-aged children, until recently there have regrettably been limited empirical efforts to clarify indicated psychological intervention methods for the treatment of mood and anxiety disorders presenting in early childhood. Young children lack many of the developmental capacities required to effectively participate in established treatments for mood and anxiety problems presenting in older children, making simple downward extensions of these treatments for the management of preschool internalizing problems misguided. In recent years, a number of research groups have successfully adapted and modified parent-child interaction therapy (PCIT), originally developed to treat externalizing problems in young children, to treat various early internalizing problems with a set of neighboring protocols. As in traditional PCIT, these extensions target child symptoms by directly reshaping parent-child interaction patterns associated with the maintenance of symptoms. The present review outlines this emerging set of novel PCIT adaptations and modifications for mood and anxiety problems in young children and reviews preliminary evidence supporting their use. Specifically, we cover (a) PCIT for early separation anxiety disorder; (b) the PCIT-CALM (Coaching Approach behavior and Leading by Modeling) Program for the full range of early anxiety disorders; (c) the group Turtle Program for behavioral inhibition; and (d) the PCIT-ED (Emotional Development) Program for preschool depression. In addition, emerging PCIT-related protocols in need of empirical attention--such as the PCIT-SM (selective mutism) Program for young children with SM--are also considered. Implications of these protocols are discussed with regard to their unique potential to address the clinical needs of young children with internalizing problems. Obstacles to broad dissemination are addressed, and we consider

  7. Safety and on-treatment efficacy of telaprevir: the early access programme for patients with advanced hepatitis C

    Science.gov (United States)

    Colombo, M; Fernández, I; Abdurakhmanov, D; Ferreira, P A; Strasser, S I; Urbanek, P; Moreno, C; Streinu-Cercel, A; Verheyen, A; Iraqi, W; DeMasi, R; Hill, A; Läuffer, J M; Lonjon-Domanec, I; Wedemeyer, H

    2014-01-01

    Background and aim Severe adverse events (AEs) compromise the outcome of direct antiviral agent-based treatment in patients with advanced liver fibrosis due to HCV infection. HEP3002 is an ongoing multinational programme to evaluate safety and efficacy of telaprevir (TVR) plus pegylated-interferon-α (PEG-IFNα) and ribavirin (RBV) in patients with advanced liver fibrosis caused by HCV genotype 1 (HCV-1). Methods 1782 patients with HCV-1 and bridging fibrosis or compensated cirrhosis were prospectively recruited from 16 countries worldwide, and treated with 12 weeks of TVR plus PEG-IFN/RBV, followed by 12 or 36 weeks of PEG-IFN and RBV (PR) alone dependent on virological response to treatment and previous response type. Results 1587 patients completed 12 weeks of triple therapy and 4 weeks of PR tail (53% cirrhosis, 22% HCV-1a). By week 12, HCV RNA was undetectable in 85% of naives, 88% of relapsers, 80% of partial responders and 72% of null responders. Overall, 931 patients (59%) developed grade 1–4 anaemia (grade 3/4 in 31%), 630 (40%) dose reduced RBV, 332 (21%) received erythropoietin and 157 (10%) were transfused. Age and female gender were the strongest predictors of anaemia. 64 patients (4%) developed a grade 3/4 rash. Discontinuation of TVR due to AEs was necessary in 193 patients (12%). Seven patients died (0.4%, six had cirrhosis). Conclusions In compensated patients with advanced fibrosis due to HCV-1, triple therapy with TVR led to satisfactory rates of safety, tolerability and on-treatment virological response with adequate managements of AEs. PMID:24201995

  8. Prime pairs and the zeta function

    NARCIS (Netherlands)

    Korevaar, J.

    2009-01-01

    Are there infinitely many prime pairs with given even difference? Most mathematicians think so. Using a strong arithmetic hypothesis, Goldston, Pintz and Yildirim have recently shown that there are infinitely many pairs of primes differing by at most sixteen. There is extensive numerical support for

  9. Phasic Affective Modulation of Semantic Priming

    Science.gov (United States)

    Topolinski, Sascha; Deutsch, Roland

    2013-01-01

    The present research demonstrates that very brief variations in affect, being around 1 s in length and changing from trial to trial independently from semantic relatedness of primes and targets, modulate the amount of semantic priming. Implementing consonant and dissonant chords (Experiments 1 and 5), naturalistic sounds (Experiment 2), and visual…

  10. 7 CFR 29.2290 - Premature primings.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Premature primings. 29.2290 Section 29.2290 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards... 21) § 29.2290 Premature primings. Ground leaves harvested before reaching complete growth and...

  11. Semilocal formal fibers of principal prime ideals

    CERN Document Server

    Chatlos, John; Watson, Nathaniel G; Wu, Sherry X

    2009-01-01

    Let (T,m) be a complete local (Notherian) ring, C a finite set of pairwise incomparable nonmaximal prime ideals of T, and p a nonzero element. We provide necessary and sufficient conditions for T to be the completion of an integral domain A containing the prime ideal pA whose formal fiber is semilocal with maximal ideals the elements of C.

  12. Goal priming as a situated intervention tool

    NARCIS (Netherlands)

    Papies, Esther K.

    2016-01-01

    Research on goal priming has shown that cues in the environment can lead to goal-directed cognition and behaviour without the need for conscious intentions. This has sparked an interest in using goal priming as an intervention tool to strategically influence behaviour in line with an individual's

  13. Syntactic priming in American Sign Language.

    Science.gov (United States)

    Hall, Matthew L; Ferreira, Victor S; Mayberry, Rachel I

    2015-01-01

    Psycholinguistic studies of sign language processing provide valuable opportunities to assess whether language phenomena, which are primarily studied in spoken language, are fundamentally shaped by peripheral biology. For example, we know that when given a choice between two syntactically permissible ways to express the same proposition, speakers tend to choose structures that were recently used, a phenomenon known as syntactic priming. Here, we report two experiments testing syntactic priming of a noun phrase construction in American Sign Language (ASL). Experiment 1 shows that second language (L2) signers with normal hearing exhibit syntactic priming in ASL and that priming is stronger when the head noun is repeated between prime and target (the lexical boost effect). Experiment 2 shows that syntactic priming is equally strong among deaf native L1 signers, deaf late L1 learners, and hearing L2 signers. Experiment 2 also tested for, but did not find evidence of, phonological or semantic boosts to syntactic priming in ASL. These results show that despite the profound differences between spoken and signed languages in terms of how they are produced and perceived, the psychological representation of sentence structure (as assessed by syntactic priming) operates similarly in sign and speech.

  14. Prime pairs and the zeta function

    NARCIS (Netherlands)

    Korevaar, J.

    2009-01-01

    Are there infinitely many prime pairs with given even difference? Most mathematicians think so. Using a strong arithmetic hypothesis, Goldston, Pintz and Yildirim have recently shown that there are infinitely many pairs of primes differing by at most sixteen. There is extensive numerical support for

  15. Can False Memories Prime Problem Solutions?

    Science.gov (United States)

    Howe, Mark L.; Garner, Sarah R.; Dewhurst, Stephen A.; Ball, Linden J.

    2010-01-01

    Previous research has suggested that false memories can prime performance on related implicit and explicit memory tasks. The present research examined whether false memories can also be used to prime higher order cognitive processes, namely, insight-based problem solving. Participants were asked to solve a number of compound remote associate task…

  16. Negative Priming in Free Recall Reconsidered

    Science.gov (United States)

    Hanczakowski, Maciej; Beaman, C. Philip; Jones, Dylan M.

    2016-01-01

    Negative priming in free recall is the finding of impaired memory performance when previously ignored auditory distracters become targets of encoding and retrieval. This negative priming has been attributed to an aftereffect of deploying inhibitory mechanisms that serve to suppress auditory distraction and minimize interference with learning and…

  17. Visual Priming of Inverted and Rotated Objects

    Science.gov (United States)

    Knowlton, Barbara J.; McAuliffe, Sean P.; Coelho, Chase J.; Hummel, John E.

    2009-01-01

    Object images are identified more efficiently after prior exposure. Here, the authors investigated shape representations supporting object priming. The dependent measure in all experiments was the minimum exposure duration required to correctly identify an object image in a rapid serial visual presentation stream. Priming was defined as the change…

  18. Phasic Affective Modulation of Semantic Priming

    Science.gov (United States)

    Topolinski, Sascha; Deutsch, Roland

    2013-01-01

    The present research demonstrates that very brief variations in affect, being around 1 s in length and changing from trial to trial independently from semantic relatedness of primes and targets, modulate the amount of semantic priming. Implementing consonant and dissonant chords (Experiments 1 and 5), naturalistic sounds (Experiment 2), and visual…

  19. Morphological Priming Survives a Language Switch

    Science.gov (United States)

    Verdonschot, Rinus G.; Middelburg, Renee; Lensink, Saskia E.; Schiller, Niels O.

    2012-01-01

    In a long-lag morphological priming experiment, Dutch (L1)-English (L2) bilinguals were asked to name pictures and read aloud words. A design using non-switch blocks, consisting solely of Dutch stimuli, and switch-blocks, consisting of Dutch primes and targets with intervening English trials, was administered. Target picture naming was facilitated…

  20. The Apollo 11 Prime Crew

    Science.gov (United States)

    1969-01-01

    Portrait of the prime crew of the Apollo 11 lunar landing mission. From left to right they are: Commander, Neil A. Armstrong, Command Module Pilot, Michael Collins, and Lunar Module Pilot, Edwin E. Aldrin Jr. On July 20th 1969 at 4:18 PM, EDT the Lunar Module 'Eagle' landed in a region of the Moon called the Mare Tranquillitatis, also known as the Sea of Tranquillity. After securing his spacecraft, Armstrong radioed back to earth: 'Houston, Tranquility Base here, the Eagle has landed'. At 10:56 p.m. that same evening and witnessed by a worldwide television audience, Neil Armstrong stepped off the 'Eagle's landing pad onto the lunar surface and said: 'That's one small step for a man, one giant leap for mankind.' He became the first human to set foot upon the Moon.

  1. Random reward priming is task-contingent

    DEFF Research Database (Denmark)

    Ásgeirsson, Árni Gunnar; Kristjánsson, Árni

    2014-01-01

    Consistent financial reward of particular features influences the allocation of visual attention in many ways. More surprising are 1-trial reward priming effects on attention where reward schedules are random and reward on one trial influences attentional allocation on the next. Those findings...... for a Gabor patch of odd spatial frequency we found no evidence of reward priming, while we only partially replicate the reward priming in the exact original paradigm tested by Hickey and colleagues. The results cast doubt on the proposal that random reward enhances salience, suggested in the original papers......, and highlight the need for a more nuanced account. In many other paradigms reward effects have been found to progress gradually, becoming stronger as they build up, and we argue that for robust reward priming, reward schedules need to be more consistent than in the original 1-trial reward priming paradigm....

  2. Prime power polynomial maps over finite fields

    CERN Document Server

    Berson, Joost

    2012-01-01

    We consider polynomial maps described by so-called prime power polynomials. These polynomials are defined using a fixed power of a prime number, say q. Considering invertible polynomial maps of this type over a characteristic zero field, we will only obtain (up to permutation of the variables) triangular maps, which are the most basic examples of polynomial automorphisms. However, over the finite field F_q automorphisms of this type have (in general) an entirely different structure. Namely, we will show that the prime power polynomial maps over F_q are in one-to-one correspondence with matrices having coefficients in a univariate polynomial ring over F_q. Furthermore, composition of polynomial maps translates to matrix multiplication, implying that invertible prime power polynomial maps correspond to invertible matrices. This alternate description of the prime power polynomial automorphism subgroup leads to the solution of many famous conjectures for this kind of polynomials and polynomial maps.

  3. Object color affects identification and repetition priming.

    Science.gov (United States)

    Uttl, Bob; Graf, Peter; Santacruz, Pilar

    2006-10-01

    We investigated the influence of color on the identification of both non-studied and studied objects. Participants studied black and white and color photos of common objects and memory was assessed with an identification test. Consistent with our meta-analysis of prior research, we found that objects were easier to identify from color than from black and white photos. We also found substantial priming in all conditions, and study-to-test changes in an object's color reduced the magnitude of priming. Color-specific priming effects were large for color-complex objects, but minimal for color-simple objects. The pattern and magnitude of priming effects was not influenced either by the extent to which an object always appears in the same color (i.e., whether a color is symptomatic of an object) or by the object's origin (natural versus fabricated). We discuss the implications of our findings for theoretical accounts of object perception and repetition priming.

  4. Random reward priming is task-contingent

    DEFF Research Database (Denmark)

    Ásgeirsson, Árni Gunnar; Kristjánsson, Árni

    2014-01-01

    Consistent financial reward of particular features influences the allocation of visual attention in many ways. More surprising are 1-trial reward priming effects on attention where reward schedules are random and reward on one trial influences attentional allocation on the next. Those findings...... for a Gabor patch of odd spatial frequency we found no evidence of reward priming, while we only partially replicate the reward priming in the exact original paradigm tested by Hickey and colleagues. The results cast doubt on the proposal that random reward enhances salience, suggested in the original papers......, and highlight the need for a more nuanced account. In many other paradigms reward effects have been found to progress gradually, becoming stronger as they build up, and we argue that for robust reward priming, reward schedules need to be more consistent than in the original 1-trial reward priming paradigm....

  5. Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir.

    Science.gov (United States)

    Younossi, Zobair M; Stepanova, Maria; Afdhal, Nezam; Kowdley, Kris V; Zeuzem, Stefan; Henry, Linda; Hunt, Sharon L; Marcellin, Patrick

    2015-08-01

    New interferon-free anti-HCV regimens are highly efficacious with a favorable safety profile. We assessed health-related quality of life (HRQL) and work productivity in patients with different stages of hepatic fibrosis treated with sofosbuvir+ledipasvir. Four questionnaires [Chronic Liver Disease Questionnaire-HCV (CLDQ-HCV), Short Form-36 (SF-36), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Work Productivity and Activity Index:Specific Health Problem (WPAI:SHP)] were administered at baseline, during, and after treatment with sofosbuvir+ledipasvir+ribavirin or sofosbuvir+ledipasvir (ION-1,2,3 clinical trials). Metavir fibrosis stage was determined from pre-treatment liver biopsies. There were 1005 patients included (stage F0: n=94; F1: n=311; F2: n=301; F3: n=197; F4: n=102). At baseline, patients with more advanced fibrosis had more HRQL impairments, predominantly related to physical functioning (stage 0 vs. stage 4 by up to 0.126 on a normalized 0-1 scale p0.05 across fibrosis stages). In multivariate analysis, advanced fibrosis was independently associated with impairment of HRQL and work productivity (beta up to -0.056 in comparison with none-to-mild fibrosis, pwork productivity after viral clearance was not related to the stage of fibrosis (all p>0.05). Although advanced hepatic fibrosis is associated with HRQL and work productivity impairment, viral eradication with sofosbuvir+ledipasvir leads to HRQL improvement regardless of fibrosis stage. HCV patients with early fibrosis experience similar improvement of patient reported outcomes as those with advanced fibrosis. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  6. Shifting evaluation windows: predictable forward primes with long SOAs eliminate the impact of backward primes.

    Science.gov (United States)

    Fockenberg, Daniel A; Koole, Sander L; Lakens, Daniël; Semin, Gün R

    2013-01-01

    Recent work suggests that people evaluate target stimuli within short and flexible time periods called evaluation windows. Stimuli that briefly precede a target (forward primes) or briefly succeed a target (backward primes) are often included in the target's evaluation. In this article, the authors propose that predictable forward primes act as "go" signals that prepare target processing, such that earlier forward primes pull the evaluation windows forward in time. Earlier forward primes may thus reduce the impact of backward primes. This shifting evaluation windows hypothesis was tested in two experiments using an evaluative decision task with predictable (vs. unpredictable) forward and backward primes. As expected, a longer time interval between a predictable forward prime and a target eliminated backward priming. In contrast, the time interval between an unpredictable forward primes and a target had no effects on backward priming. These findings suggest that predictable features of dynamic stimuli can shape target extraction by determining which information is included (or excluded) in rapid evaluation processes.

  7. Effect of seed priming on agronomic performance and cost ...

    African Journals Online (AJOL)

    Effect of seed priming on agronomic performance and cost effectiveness of rainfed, dry-seeded nerica rice. ... Open Access DOWNLOAD FULL TEXT ... vitamin (Ascorbate) priming, hardening, osmohardening, and a non-primed control.

  8. Movement-Based Priming: Clinical Applications and Neural Mechanisms.

    Science.gov (United States)

    Stoykov, Mary Ellen; Corcos, Daniel Montie; Madhavan, Sangeetha

    2017-01-01

    Priming can be described as behavior change generated by preceding stimuli. Although various types of priming have been long studied in the field of psychology, priming that targets motor cortex is a relatively new topic of research in the fields of motor control and rehabilitation. In reference to a rehabilitation intervention, priming is categorized as a restorative approach. There are a myriad of possible priming approaches including noninvasive brain stimulation, motor imagery, and sensory-based priming, to name a few. The authors report on movement-based priming which, compared to other priming types, is less frequently examined and under reported. Movement-based priming includes, but is not limited to, bilateral motor priming, unilateral priming, and aerobic exercise. Clinical and neural mechanistic aspects of movement-based priming techniques are explored.

  9. Exponential sums over primes in short intervals

    Institute of Scientific and Technical Information of China (English)

    LIU; Jianya

    2006-01-01

    [1]Vinogradov,I.M.,Estimation of certain trigonometric sums with prime variables,Izv.Acad.Nauk.SSSR,1939,3:371-398.[2]Zhan,T.,On the representation of large odd integer as a sum of three almost equal primes,Acta Math.Sin.,1991,7:259-272.[3]Ren,X.M.,On exponential sums over primes and application in the Waring-Goldbach problem,Sci.China,Ser.A-Math.,2005,48(6):785-797.[4]Liu,J.Y.,Wooley,T.D.,Yu,G.,The quadratic Waring-Goldbach problem,J.Number Theory,2004,107:298-321.[5]Hua,L.K.,Some results in the additive prime number theory,Quart.J.Math.(Oxford),1938,9:68-80.[6]Liu,J.Y.,Zhan,T.,On sums of five almost equal prime squares,Acta Arith.,1996,77:369-383.[7]Bauer,C.,A note on sums of five almost equal prime squares,Arch.Math,1997,69:20-30.[8]Liu,J.Y.,Zhan,T.,Sums of five almost equal prime squares,Science in China,Ser.A,1998,41:710-722.[9]Liu,J.Y.,Zhan,T.,Hua's theorem on prime squares in short intervals,Acta Math.Sin.,2000,16:1-22.[10]Bauer,C.,Sums of five almost equal prime squares,Acta Math.Sin.,2005,21(4):833-840.[11]Lü,G.S.,Hua's Theorem with five almost equal prime variables,Chin.Ann.Math.,Ser.B,2005,26(2):291-304.[12]Vinogradov,I.M.,Elements of Number Theory,Dover Publications,1954.[13]Titchmarsh,E.C.,The Theory of the Riemann Zeta-function,2nd ed.,Oxford:Oxford University Press,1986.

  10. E 1 transitions from the. Upsilon. prime prime state and the fine structure of the. chi. sub b prime states

    Energy Technology Data Exchange (ETDEWEB)

    Narain, M.; Lovelock, D.M.J.; Heintz, U.; Lee-Franzini, J.; Schamberger, R.D.; Willins, J.; Yanagisawa, C. (State University of New York at Stony Brook, Stony Brook, New York 11794 (USA)); Franzini, P.; Tuts, P.M.; Kanekal, S.; Wu, Q.W. (Columbia University, New York, New York 10027 (USA))

    1991-06-17

    Using the CUSB-II detector at the Cornell Electron Storage Ring, we have made precision measurements of the electric dipole transition rates from {Upsilon}{prime}{prime} to {chi}{sub {ital b}}{sup {prime}}, which are in excellent agreement with theory. The fine-structure splitting is found to be {ital M}({chi}{sub {ital b}2}{sup {prime}}){minus}{ital M}({chi}{sub {ital b}1}{sup {prime}})=13.5{plus minus}0.4{plus minus}0.5 MeV and {ital M}({chi}{sub {ital b}1}{sup {prime}}){minus}{ital M}({chi}{sub {ital b}0}{sup {prime}})=23.3{plus minus}0.7{plus minus}0.7 MeV, leading to a ratio {ital R}=0.584{plus minus}0.024{plus minus}0.02. The fine structure measures the relative contributions of the spin-orbit interaction {ital a}=9.5{plus minus}0.2{plus minus}0.1 MeV and tensor interaction {ital b}=2.3{plus minus}0.1{plus minus}0.1 MeV. We also find that the long-range confining potential transforms as a Lorentz scalar.

  11. Eye movements reveal fast, voice-specific priming.

    Science.gov (United States)

    Papesh, Megan H; Goldinger, Stephen D; Hout, Michael C

    2016-03-01

    In spoken word perception, voice specificity effects are well-documented: When people hear repeated words in some task, performance is generally better when repeated items are presented in their originally heard voices, relative to changed voices. A key theoretical question about voice specificity effects concerns their time-course: Some studies suggest that episodic traces exert their influence late in lexical processing (the time-course hypothesis; McLennan & Luce, 2005), whereas others suggest that episodic traces influence immediate, online processing. We report 2 eye-tracking studies investigating the time-course of voice-specific priming within and across cognitive tasks. In Experiment 1, participants performed modified lexical decision or semantic classification to words spoken by 4 speakers. The tasks required participants to click a red "x" or a blue "+" located randomly within separate visual half-fields, necessitating trial-by-trial visual search with consistent half-field response mapping. After a break, participants completed a second block with new and repeated items, half spoken in changed voices. Voice effects were robust very early, appearing in saccade initiation times. Experiment 2 replicated this pattern while changing tasks across blocks, ruling out a response priming account. In the General Discussion, we address the time-course hypothesis, focusing on the challenge it presents for empirical disconfirmation, and highlighting the broad importance of indexical effects, beyond studies of priming.

  12. An Investigation of Syntactic Priming among German Speakers at Varying Proficiency Levels

    Science.gov (United States)

    Ruf, Helena T.

    2011-01-01

    This dissertation investigates syntactic priming in second language (L2) development among three speaker populations: (1) less proficient L2 speakers; (2) advanced L2 speakers; and (3) LI speakers. Using confederate scripting this study examines how German speakers choose certain word orders in locative constructions (e.g., "Auf dem Tisch…

  13. Phonological and Orthographic Overlap Effects in Fast and Masked Priming

    Science.gov (United States)

    Frisson, Steven; Bélanger, Nathalie N.; Rayner, Keith

    2014-01-01

    We investigated how orthographic and phonological information is activated during reading, using a fast priming task, and during single word recognition, using masked priming. Specifically, different types of overlap between prime and target were contrasted: high orthographic and high phonological overlap (track-crack), high orthographic and low phonological overlap (bear-gear), or low orthographic and high phonological overlap (fruit-chute). In addition, we examined whether (orthographic) beginning overlap (swoop-swoon) yielded the same priming pattern as end (rhyme) overlap (track-crack). Prime durations were 32 and 50ms in the fast priming version, and 50ms in the masked priming version, and mode of presentation (prime and target in lower case) was identical. The fast priming experiment showed facilitatory priming effects when both orthography and phonology overlapped, with no apparent differences between beginning and end overlap pairs. Facilitation was also found when prime and target only overlapped orthographically. In contrast, the masked priming experiment showed inhibition for both types of end overlap pairs (with and without phonological overlap), and no difference for begin overlap items. When prime and target only shared principally phonological information, facilitation was only found with a long prime duration in the fast priming experiment, while no differences were found in the masked priming version. These contrasting results suggest that fast priming and masked priming do not necessarily tap into the same type of processing. PMID:24365065

  14. Phonological and orthographic overlap effects in fast and masked priming.

    Science.gov (United States)

    Frisson, Steven; Bélanger, Nathalie N; Rayner, Keith

    2014-01-01

    We investigated how orthographic and phonological information is activated during reading, using a fast priming task, and during single-word recognition, using masked priming. Specifically, different types of overlap between prime and target were contrasted: high orthographic and high phonological overlap (track-crack), high orthographic and low phonological overlap (bear-gear), or low orthographic and high phonological overlap (fruit-chute). In addition, we examined whether (orthographic) beginning overlap (swoop-swoon) yielded the same priming pattern as end (rhyme) overlap (track-crack). Prime durations were 32 and 50 ms in the fast priming version and 50 ms in the masked priming version, and mode of presentation (prime and target in lower case) was identical. The fast priming experiment showed facilitatory priming effects when both orthography and phonology overlapped, with no apparent differences between beginning and end overlap pairs. Facilitation was also found when prime and target only overlapped orthographically. In contrast, the masked priming experiment showed inhibition for both types of end overlap pairs (with and without phonological overlap) and no difference for begin overlap items. When prime and target only shared principally phonological information, facilitation was only found with a long prime duration in the fast priming experiment, while no differences were found in the masked priming version. These contrasting results suggest that fast priming and masked priming do not necessarily tap into the same type of processing.

  15. PRIMING OF OBJECT CATEGORIZATION WITHIN AND ACROSS LEVELS OF SPECIFICITY

    Directory of Open Access Journals (Sweden)

    Matthias M. Müller

    2009-02-01

    Full Text Available Identification of objects can occur at different levels of specificity. Dependingon task and context, an object can be classified at the superordinate level (as ananimal, at the basic level (a bird or at the subordinate level (a sparrow. Whatare the interactions between these representational levels and do they rely onthe same sequential processes that lead to successful object identification? Inthis electroencephalogram study, a task-switching paradigm (covert naming orliving/non-living judgment was used. Images of objects were repeated eitherwithin the same task, or with a switch from a covert naming task to a livingor non-living judgment and vice versa. While covert naming accesses entrylevel(basic or subordinate, living/non-living judgments rely on superordinateclassification. Our beha-vioural results demonstrated clear priming effectswithin both tasks. However, asymmetries were found when task-switching hadoccurred, with facilitation for covert naming but not for categorization. Wealso found lower accuracy and early-starting and persistent enhancements ofevent-related potentials (ERPs for covert naming, indicating that this task wasmore difficult and involved more intense perceptual and semantic processing.Perceptual priming was marked by consistent reductions of the ERP componentL1 for repeated presentations, both with and without task switching. Additionalrepetition effects were found in early event-related activity between 150-190 ms(N1 when a repeated image had been named at initial presentation. We conclude that differences in N1 indicate task-related changes in the identification processitself. Such enhancements for covert naming again emerge in a later timewindow associated with depth of semantic processing. Meanwhile, L1 reflectsmodulations due to implicit memory of objects. In conclusion, evidence wasfound for representational overlap; changes in ERP markers started early andrevealed cross-task priming at the level of object

  16. Enhanced Tomato Disease Resistance Primed by Arbuscular Mycorrhizal Fungus

    Directory of Open Access Journals (Sweden)

    Yuanyuan eSong

    2015-09-01

    Full Text Available Roots of most terrestrial plants form symbiotic associations (mycorrhiza with soil- borne arbuscular mycorrhizal fungi (AMF. Many studies show that mycorrhizal colonization enhances plant resistance against pathogenic fungi. However, the mechanism of mycorrhiza-induced disease resistance remains equivocal. In this study, we found that mycorrhizal inoculation with AMF Funneliformis mosseae significantly alleviated tomato (Solanum lycopersicum Mill. early blight disease caused by Alternaria solani Sorauer. AMF pre-inoculation led to significant increases in activities of β-1,3-glucanase, chitinase, phenylalanine ammonia-lyase (PAL and lipoxygenase (LOX in tomato leaves upon pathogen inoculation. Mycorrhizal inoculation alone did not influence the transcripts of most genes tested. However, pathogen attack on AMF-inoculated plants provoked strong defense responses of three genes encoding pathogenesis-related (PR proteins, PR1, PR2 and PR3, as well as defense-related genes LOX, AOC and PAL, in tomato leaves. The induction of defense responses in AMF pre-inoculated plants was much higher and more rapid than that in un-inoculated plants in present of pathogen infection. Three tomato genotypes: a Castlemart wild-type (WT plant, a jasmonate (JA biosynthesis mutant (spr2, and a prosystemin-overexpressing 35S::PS plant were used to examine the role of the JA signaling pathway in AMF-primed disease defense. Pathogen infection on mycorrhizal 35S::PS plants led to higher induction of defense-related genes and enzymes relative to WT plants. However, pathogen infection did not induce these genes and enzymes in mycorrhizal spr2 mutant plants. Bioassays showed that 35S::PS plants were more resistant and spr2 plants were more susceptible to early blight compared with WT plants. Our finding indicates that mycorrhizal colonization enhances tomato resistance to early blight by priming systemic defense response, and the JA signaling pathway is essential for

  17. Enhanced tomato disease resistance primed by arbuscular mycorrhizal fungus

    Science.gov (United States)

    Song, Yuanyuan; Chen, Dongmei; Lu, Kai; Sun, Zhongxiang; Zeng, Rensen

    2015-01-01

    Roots of most terrestrial plants form symbiotic associations (mycorrhiza) with soil- borne arbuscular mycorrhizal fungi (AMF). Many studies show that mycorrhizal colonization enhances plant resistance against pathogenic fungi. However, the mechanism of mycorrhiza-induced disease resistance remains equivocal. In this study, we found that mycorrhizal inoculation with AMF Funneliformis mosseae significantly alleviated tomato (Solanum lycopersicum Mill.) early blight disease caused by Alternaria solani Sorauer. AMF pre-inoculation led to significant increases in activities of β-1,3-glucanase, chitinase, phenylalanine ammonia-lyase (PAL) and lipoxygenase (LOX) in tomato leaves upon pathogen inoculation. Mycorrhizal inoculation alone did not influence the transcripts of most genes tested. However, pathogen attack on AMF-inoculated plants provoked strong defense responses of three genes encoding pathogenesis-related proteins, PR1, PR2, and PR3, as well as defense-related genes LOX, AOC, and PAL, in tomato leaves. The induction of defense responses in AMF pre-inoculated plants was much higher and more rapid than that in un-inoculated plants in present of pathogen infection. Three tomato genotypes: a Castlemart wild-type (WT) plant, a jasmonate (JA) biosynthesis mutant (spr2), and a prosystemin-overexpressing 35S::PS plant were used to examine the role of the JA signaling pathway in AMF-primed disease defense. Pathogen infection on mycorrhizal 35S::PS plants led to higher induction of defense-related genes and enzymes relative to WT plants. However, pathogen infection did not induce these genes and enzymes in mycorrhizal spr2 mutant plants. Bioassays showed that 35S::PS plants were more resistant and spr2 plants were more susceptible to early blight compared with WT plants. Our finding indicates that mycorrhizal colonization enhances tomato resistance to early blight by priming systemic defense response, and the JA signaling pathway is essential for mycorrhiza-primed

  18. Re-naming D Double Prime

    Science.gov (United States)

    Chao, Benjamin F.

    1999-01-01

    "Knowledge about the dynamics of the D double prime region is a key to unlock some fundamental mysteries of the Earth heat engine which governs a wide range of global geophysical processes from tectonics to geodynamo." This benign sentence makes complete sense to many geophysicists. But for many others, it makes sense all except the odd nomenclature "D double prime". One knows about the crust, upper and lower mantle, outer and inner core, but where is the D double prime region? What meaning does it try to convey? Where is D prime region, or D, or A, B, C regions for that matter, and are there higher-order primes? How does such an odd name come about anyway? D double prime, or more "simply" D", is a generic designation given to the thin shell, about 200 km thick, of the lowermost mantle just above the core-mantle boundary inside the Earth. Incidentally, whether D" is "simpler" than "D double prime" depends on whether you are pronouncing it or writing/typing it; and D" can be confusing to readers in distinguishing quotation marks (such as in the above sentences) and second derivatives, and to word processors in spelling check and indexing.

  19. Locally advanced adenocarcinoma of the rectum presenting with necrotising fasciitis of the perineum: successful management with early aggressive surgery and multimodal therapy.

    Science.gov (United States)

    Ferreira, Luís; Alexandrino, Henrique; Soares Leite, Júlio; Castro Sousa, Francisco

    2015-12-16

    Colorectal cancer is a common malignant neoplasm and its treatment usually involves surgery associated, in some cases, depending on the staging, with chemoradiotherapy. Necrotising fasciitis of the perineum is a highly lethal infection of the perineum, perirectal tissues and genitals, requiring emergency surgical debridement, broad-spectrum antibiotics and control of sepsis. We present the case of a 59-year-old man with necrotising fasciitis of the perineum as the first clinical manifestation of locally advanced adenocarcinoma of the rectum, in which successful management consisted of early and aggressive surgical debridement, followed by multimodal therapy with curative intent. 2 years and 6 months after surgery the patient is well, with no evidence of local or systemic relapse.

  20. Early Diagnosis and Treatment of Coronary Heart Disease in Symptomatic Subjects With Advanced Vascular Atherosclerosis of the Carotid Artery (Type III and IV b Findings Using Ultrasound)

    Science.gov (United States)

    Adams, Ansgar; Bojara, Waldemar; Schunk, Klaus

    2017-01-01

    Background A study was conducted as to whether the early diagnosis of coronary heart disease (CHD) in symptomatic patients with advanced atherosclerosis of the carotid artery was more successful using ultrasound technology than exercise electrocardiography (ECG). Methods Within the scope of an occupational screening program using subjects from diverse employment sectors, people were given the opportunity to determine their risk of heart attack. During the study, the total plaque area (TPA), the maximum plaque thickness in the carotid artery and the PROCAM scores of 3,513 healthy men and 2,088 healthy women between the ages of 20 and 65 were determined. During the subsequent follow-up study, 36 subjects developed symptoms such as exertional dyspnea, atypical angina pectoris (AP) or typical AP. Four patients displayed no symptoms. The initial cardiac diagnostic testing was conducted on 31 patients using an exercise ECG, four patients were assessed using a coronary angiogram, and five further patients were assessed using a computed tomography (CT) coronary angiogram. An ultrasound examination of the carotid artery of 39 patients revealed a type IV b finding and in one patient, the examination revealed a type III finding. Results In 17 patients, the PROCAM score was 20%. In the final analysis, only two patients had entirely smooth coronary arteries, seven had coronary sclerosis, seven had a 30% stenosis, one had a 30-40% stenosis, one had a 40% stenosis, and 22 patients had a stenosis ≥ 50%, and in extreme cases, a left main coronary artery stenosis with three-vessel disease was shown. The exercise ECG only achieved a true positive result in four patients, and in 21 patients, the result was false negative. Conclusions Symptomatic patients with advanced atherosclerosis of the carotid artery (type III and type IV b findings) had a high risk for CHD. The diagnosis of CHD is better achieved by using carotid duplex than with an exercise ECG. Early treatment of the disease

  1. Field establishment and grain yield of maize affected by hydro-priming of differentially aged seeds

    Directory of Open Access Journals (Sweden)

    Kazem Ghassemi-Golezani

    2017-02-01

    Full Text Available A sub-sample of maize seeds (cv. SC-AR68 with a 100% germination was kept as control, and two other sub-samples were artificially deteriorated at 40 °C for 2 and 3 days, reducing normal germination to 98% and 93%, respectively. Consequently, three seed lots of maize with different levels of vigor were provided. Each seed lot was then divided into four sub-samples, one unprimed and the other three lots were primed in distilled water at 15 °C for 7, 14 and 21 hours, and then dried back to initial moisture content (about 20% at a room temperature of 20–22 °C for 24 hours. The field experiment was arranged as factorial based on randomized complete block design with three replications. Although germination percentage of seed lots was not significantly affected by hydro-priming, germination rate and seedling dry weight were considerably enhanced as a result of seed priming. Hydro-priming for 21 hours enhanced seedling emergence rate of all seed lots with different levels of vigor. This hydro-priming duration also increased grain yield of maize by about 32%, although this superiority was not statistically significant. This advantage in grain yield of plants from primed seeds was related with rapid germination and seedling growth and early emergence in the field.

  2. Visuo-perceptive priming in Alzheimer's disease: evidence for a multi-componential implicit memory system.

    Science.gov (United States)

    Boccia, Maddalena; Silveri, Maria Caterina; Guariglia, Cecilia

    2014-01-01

    In the past two decades research has highlighted how implicit memory processes are spared in degenerative disorders, such as Alzheimer's disease (AD), which are characterized by the early onset of explicit memory deficits. However, according to recent studies, there may be dissociations among different types of implicit memory. Although several studies have shown selective sparing of lexical priming in AD, it is not completely clear what happens to other types of implicit memory processes, such as visuo-perceptual priming. The present study examines the possibility that the visuo-perceptual priming effect is spared in AD. We tested two groups of participants, i.e., a group of AD patients and a group of healthy age-matched controls, using a visuo-perceptual priming task. The task required the identification of fragmented pictures. Results showed a deficient priming effect in AD patients when it was measured by an Identification of Fragmented Pictures task. We discuss our results in light of the current hypothesis of a functional segregation in priming processes.

  3. 模糊Prime元%Fuzzy Prime Elements

    Institute of Scientific and Technical Information of China (English)

    饶三平

    2012-01-01

    基于完备剩余格,本文在模糊完备格中,引入模糊Prime元概念.给出了模糊Prime元的等价刻画,证明了所有的模糊Prime元构成的模糊集是模糊完全分配格.%Based on complete residuated lattices, the concept of fuzzy Prime elements in fuzzy complete lattices is given, then the equivalent characterization of fuzzy Prime elements is obtained. We also prove that the fuzzy subsets of fuzzy Prime elements is a fuzzy completely distributice lattice.

  4. An introduction to E-Prime

    Directory of Open Access Journals (Sweden)

    Dominic Charbonneau

    2009-09-01

    Full Text Available When running an experiment, precision is essential to ensure results are as exact as possible. Thus, computers, which offer endless accuracy, have become an inevitable tool to design experiments. To avoid programming from scratch for each new situation, a program, E-Prime, has been created to ease the conception of experiments. E-Prime, developed by PSTNet, offers a user-friendly interface that makes typical experiments easy to create. This paper shows how to effortlessly create an experiment with E-Prime, followed by a simple example.

  5. A Paradox of Syntactic Priming: Why Response Tendencies Show Priming for Passives, and Response Latencies Show Priming for Actives

    NARCIS (Netherlands)

    Segaert, K.R.; Menenti, L.M.E.; Weber, K.M.; Hagoort, P.

    2011-01-01

    Speakers tend to repeat syntactic structures across sentences, a phenomenon called syntactic priming. Although it has been suggested that repeating syntactic structures should result in speeded responses, previous research has focused on effects in response tendencies. We investigated syntactic

  6. Three-dimensional power Doppler ultrasound in the early assessment of response to concurrent chemo-radiotherapy for advanced cervical cancer.

    Science.gov (United States)

    Xu, Yan; Zhu, Lijing; Ru, Tong; Wang, Huanhuan; He, Jian; Zhou, Zhengyang; Yang, Xiaofeng

    2017-09-01

    Background Three-dimensional power Doppler ultrasound (3D-PDU) imaging has been widely applied to the differentiation of benign and malignant cervical lesions; however, its potential value for predicting response to chemo-radiotherapy has not been fully explored. Purpose To investigate the feasibility of 3D-PDU imaging in predicting treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for advanced cervical cancer. Material and Methods Fifty-two patients with advanced cervical cancer who received CCRT underwent 3D-PDU examinations at four timepoints: pre-therapy (baseline), 1 week and 2 weeks during, as well as immediately post CCRT. Final tumor response was determined by change in tumor size using magnetic resonance imaging (MRI). Cervical tumor volumes and vascular indices were calculated and compared with the clinical outcome. Results Of the 52 patients, 32 patients who completed all four examinations were included in the analyses: 21 were classified as complete response (CR) and 11 as partial response (PR). During the treatment, the CR group showed that 3D vascular indices (VI and VFI) significantly increased at 1 week ( P = 0.028, P = 0.017, respectively) then decreased at 2 weeks and obviously decreased at therapy completion (both P  0.05). Conclusion Prospective longitudinal 3D-PDU imaging may have potentials in monitoring early therapeutic response to CCRT in patients with cervical cancer.

  7. Prime Focus Spectrograph - Subaru's future -

    CERN Document Server

    Sugai, Hajime; Takato, Naruhisa; Tamura, Naoyuki; Shimono, Atsushi; Ohyama, Youichi; Ueda, Akitoshi; Ling, Hung-Hsu; de Arruda, Marcio Vital; Barkhouser, Robert H; Bennett, Charles L; Bickerton, Steve; Braun, David F; Bruno, Robin J; Carr, Michael A; Oliveira, João Batista de Carvalho; Chang, Yin-Chang; Chen, Hsin-Yo; Dekany, Richard G; Dominici, Tania Pereira; Ellis, Richard S; Fisher, Charles D; Gunn, James E; Heckman, Timothy M; Ho, Paul T P; Hu, Yen-Shan; Jaquet, Marc; Karr, Jennifer; Kimura, Masahiko; Fèvre, Olivier Le; Mignant, David Le; Loomis, Craig; Lupton, Robert H; Madec, Fabrice; Marrara, Lucas Souza; Martin, Laurent; Murayama, Hitoshi; de Oliveira, Antonio Cesar; de Oliveira, Claudia Mendes; de Oliveira, Ligia Souza; Orndorff, Joe D; Vilaça, Rodrigo de Paiva; Macanhan, Vanessa Bawden de Paula; Prieto, Eric; Santos, Jesulino Bispo dos; Seiffert, Michael D; Smee, Stephen A; Smith, Roger M; Sodré, Laerte; Spergel, David N; Surace, Christian; Vives, Sebastien; Wang, Shiang-Yu; Yan, Chi-Hung

    2012-01-01

    The Prime Focus Spectrograph (PFS) of the Subaru Measurement of Images and Redshifts (SuMIRe) project has been endorsed by Japanese community as one of the main future instruments of the Subaru 8.2-meter telescope at Mauna Kea, Hawaii. This optical/near-infrared multi-fiber spectrograph targets cosmology with galaxy surveys, Galactic archaeology, and studies of galaxy/AGN evolution. Taking advantage of Subaru's wide field of view, which is further extended with the recently completed Wide Field Corrector, PFS will enable us to carry out multi-fiber spectroscopy of 2400 targets within 1.3 degree diameter. A microlens is attached at each fiber entrance for F-ratio transformation into a larger one so that difficulties of spectrograph design are eased. Fibers are accurately placed onto target positions by positioners, each of which consists of two stages of piezo-electric rotary motors, through iterations by using back-illuminated fiber position measurements with a wide-field metrology camera. Fibers then carry l...

  8. 奶牛早期妊娠诊断研究进展%Advances in Researches of Early Pregnancy Diagnosis of Dairy Cow

    Institute of Scientific and Technical Information of China (English)

    卜建华; 雷静; 李艳艳; 脱征军; 梁小军

    2015-01-01

    奶牛早期妊娠诊断是确保繁殖机能正常发挥、缩短胎间距、提高经济效益的重要手段.现阶段该技术在规模化程度较高的奶牛场被广泛应用,能及时发现空怀奶牛;同时,若配合同期发情技术,可使空怀奶牛实现及时发现、及时处理、及时参配,可以提高奶牛场的繁殖效率. 本文综述了奶牛的早期妊娠诊断技术及其研究进展.%Early pregnancy diagnosis of dairy cow is an important approach to ensure the normal play of reproduction func-tion, shorten the breeding interval and improve the economic efficiency. Presently the technology is being used widely in the dairy farms with relatively large sizes and makes the nonpregnancy cows found in time. At the same time, if the estrus syn-chronization technology is used together, the nonpregnancy cows could be found in time, treated in time and mate in time and the reproductive efficiency of dairy farms could be improved. The early pregnancy diagnosis technology for dairy cow as well as the advances in its researches is summed up in the paper.

  9. Early expression of the receptor for advanced glycation end products in a toxic model produced by 6-hydroxydopamine in the rat striatum.

    Science.gov (United States)

    Serratos, Iris N; Castellanos, Pilar; Pastor, Nina; Millán-Pacheco, César; Colín-González, Ana Laura; Rembao, Daniel; Pérez-Montfort, Ruy; Cabrera, Nallely; Sánchez-García, Aurora; Gómez, Isabel; Rangel-López, Edgar; Santamaria, Abel

    2016-04-05

    The receptor for advanced glycation end products (RAGE) is commonly involved in different neurodegenerative and inflammatory disorders. The cellular signaling associated to RAGE activation may occur upon binding to different ligands. In this study we investigated whether the toxic model produced by 6-hydroxydopamine (6-OHDA) in rats comprises early noxious responses related to RAGE-mediated signaling cascades. In order to explore a possible interaction between 6-OHDA and RAGE, affinity parameters of RAGE with 6-OHDA were estimated by different means. The possible binding sites of 6-OHDA with the VC1 homodimer for both rat and human RAGE were also modeled. Our results show that the striatal infusion of 6-OHDA recruits RAGE upregulation, as evidenced by an early expression of the receptor. 6-OHDA was also found to bind the VC1 homodimer, although its affinity was moderate when compared to other ligands. This work contributes to the understanding of the role of RAGE activation for 6-OHDA-induced neurotoxicity.

  10. Early bedside care during preclinical medical education: can technology-enhanced patient simulation advance the Flexnerian ideal?

    Science.gov (United States)

    Gordon, James A; Hayden, Emily M; Ahmed, Rami A; Pawlowski, John B; Khoury, Kimberly N; Oriol, Nancy E

    2010-02-01

    Flexner wanted medical students to study at the patient bedside-a remarkable innovation in his time-so that they could apply science to clinical care under the watchful eye of senior physicians. Ever since his report, medical schools have reserved the latter years of their curricula for such an "advanced" apprenticeship, providing clinical clerkship experiences only after an initial period of instruction in basic medical sciences. Although Flexner codified the segregation of preclinical and clinical instruction, he was committed to ensuring that both domains were integrated into a modern medical education. The aspiration to fully integrate preclinical and clinical instruction continues to drive medical education reform even to this day. In this article, the authors revisit the original justification for sequential preclinical-clinical instruction and argue that modern, technology-enhanced patient simulation platforms are uniquely powerful for fostering simultaneous integration of preclinical-clinical content in a way that Flexner would have applauded. To date, medical educators tend to focus on using technology-enhanced medical simulation in clinical and postgraduate medical education; few have devoted significant attention to using immersive clinical simulation among preclinical students. The authors present an argument for the use of dynamic robot-mannequins in teaching basic medical science, and describe their experience with simulator-based preclinical instruction at Harvard Medical School. They discuss common misconceptions and barriers to the approach, describe their curricular responses to the technique, and articulate a unifying theory of cognitive and emotional learning that broadens the view of what is possible, feasible, and desirable with simulator-based medical education.

  11. Risk of Pathologic Upgrading or Locally Advanced Disease in Early Prostate Cancer Patients Based on Biopsy Gleason Score and PSA: A Population-Based Study of Modern Patients

    Energy Technology Data Exchange (ETDEWEB)

    Caster, Joseph M.; Falchook, Aaron D. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Hendrix, Laura H. [Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Chen, Ronald C., E-mail: Ronald_chen@med.unc.edu [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States)

    2015-06-01

    Purpose: Radiation oncologists rely on available clinical information (biopsy Gleason score and prostate-specific antigen [PSA]) to determine the optimal treatment regimen for each prostate cancer patient. Existing published nomograms correlating clinical to pathologic extent of disease were based on patients treated in the 1980s and 1990s at select academic institutions. We used the Surveillance, Epidemiology, and End Results (SEER) database to examine pathologic outcomes (Gleason score and cancer stage) in early prostate cancer patients based on biopsy Gleason score and PSA concentration. Methods and Materials: This analysis included 25,858 patients whose cancer was diagnosed between 2010 and 2011, with biopsy Gleason scores of 6 to 7 and clinical stage T1 to T2 disease, who underwent radical prostatectomy. In subgroups based on biopsy Gleason score and PSA level, we report the proportion of patients with pathologically advanced disease (positive surgical margin or pT3-T4 disease) or whose Gleason score was upgraded. Logistic regression was used to examine factors associated with pathologic outcomes. Results: For patients with biopsy Gleason score 6 cancers, 84% of those with PSA <10 ng/mL had surgical T2 disease with negative margins; this decreased to 61% in patients with PSA of 20 to 29.9 ng/mL. Gleason score upgrading was seen in 43% (PSA: <10 ng/mL) to 61% (PSA: 20-29.9 ng/mL) of biopsy Gleason 6 patients. Patients with biopsy Gleason 7 cancers had a one-third (Gleason 3 + 4; PSA: <10 ng/mL) to two-thirds (Gleason 4 + 3; PSA: 20-29.9 ng/mL) probability of having pathologically advanced disease. Gleason score upgrading was seen in 11% to 19% of patients with biopsy Gleason 4 + 3 cancers. Multivariable analysis showed that higher PSA and older age were associated with Gleason score upgrading and pathologically advanced disease. Conclusions: This is the first population-based study to examine pathologic extent of disease and pathologic Gleason score

  12. Pakistan prime minister pledges science boost

    CERN Multimedia

    1999-01-01

    Pakistan's prime minister announced plans for a 1 billion rupee (23 million US dollars) investment in science and technology. About half is expected to be spent on research and infrasture, the rest on science education (6 paragraphs).

  13. Riemann equation for prime number diffusion.

    Science.gov (United States)

    Chen, Wen; Liang, Yingjie

    2015-05-01

    This study makes the first attempt to propose the Riemann diffusion equation to describe in a manner of partial differential equation and interpret in physics of diffusion the classical Riemann method for prime number distribution. The analytical solution of this equation is the well-known Riemann representation. The diffusion coefficient is dependent on natural number, a kind of position-dependent diffusivity diffusion. We find that the diffusion coefficient of the Riemann diffusion equation is nearly a straight line having a slope 0.99734 in the double-logarithmic axis. Consequently, an approximate solution of the Riemann diffusion equation is obtained, which agrees well with the Riemann representation in predicting the prime number distribution. Moreover, we interpret the scale-free property of prime number distribution via a power law function with 1.0169 the scale-free exponent in respect to logarithmic transform of the natural number, and then the fractal characteristic of prime number distribution is disclosed.

  14. Syntactic Variance and Priming Effects in Translation

    DEFF Research Database (Denmark)

    Bangalore, Srinivas; Behrens, Bergljot; Carl, Michael

    2016-01-01

    The present work investigates the relationship between syntactic variation and priming in translation. It is based on the claim that languages share a common cognitive network of neural activity. When the source and target languages are solicited in a translation context, this shared network can...... on the syntactic level. We tested these hypotheses with translation data from the TPR database, more specifically for three language pairs (English-German, English-Danish, and English-Spanish). Our results show that response times are shorter when syntactic structures are shared. The model explains this through...... lead to facilitation effects, so-called priming effects. We suggest that priming is a default setting in translation, a special case of language use where source and target languages are constantly co-activated. Such priming effects are not restricted to lexical elements, but do also occur...

  15. SATDA teams up with American Prime Group

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>With over 37 years of experience in the real estate industry, American Prime, a family owned and operated company, headquartered in Miami, Florida, is an industry leader in the developing, marketing, selling, and financing of real

  16. Diverging Influences of Money Priming on Choice.

    Science.gov (United States)

    Kim, Hee Jin

    2017-01-01

    Prior research on money priming has suggested two seemingly contradicting findings. On the one hand, money has been shown to highlight the importance of cost saving, leading to the choice of a low-quality/low-price option. On the other hand, individuals primed with money as a symbol of social status, and capabilities may focus on social value of money, e.g., higher spending symbolizes higher status and prefer an option with high quality/high price. Current research proposes and demonstrates that whether money priming will lead different choices depends on the nature of the consumption context. Specifically, when the product is to be consumed privately, money priming will highlight the importance of cost, thus increasing the preference for lower price at a lower quality. However, when the product is to be consumed publicly, reversed pattern of consumer preference will be found.

  17. Reconciling Mechanistic Hypotheses About Rhizosphere Priming

    Science.gov (United States)

    Cheng, W.

    2016-12-01

    Rhizosphere priming on soil organic matter decomposition has emerged as a key mechanism regulating biogeochemnical cycling of carbon, nitrogen and other elements from local to global scales. The level of the rhizosphere priming effect on decomposition rates can be comparable to the levels of controls from soil temperature and moisture conditions. However, our understanding on mechanisms responsible for rhizosphere priming remains rudimentary and controversial. The following individual hypotheses have been postulated in the published literature: (1) microbial activation, (2) microbial community succession, (3) aggregate turnover, (4) nitrogen mining, (5) nutrient competition, (6) preferential substrate utilization, and (7) drying-rewetting. Meshing these hypotheses with existing empirical evidence tends to support a general conclusion: each of these 7 hypotheses represents an aspect of the overall rhizosphere priming complex while the relative contribution by each individual aspect varies depending on the actual plant-soil conditions across time and space.

  18. Suggestibility and negative priming: two replication studies.

    Science.gov (United States)

    David, Daniel; Brown, Richard J

    2002-07-01

    Research suggests that inhibiting the effect of irrelevant stimuli on subsequent thought and action (cognitive inhibition) may be an important component of suggestibility. Two small correlation studies were conducted to address the relationship between different aspects of suggestibility and individual differences in cognitive inhibition, operationalized as the degree of negative priming generated by to-be-ignored stimuli in a semantic categorization task. The first study found significant positive correlations between negative priming, hypnotic suggestibility, and creative imagination; a significant negative correlation was obtained between negative priming and interrogative suggestibility, demonstrating the discriminant validity of the study results. The second study replicated the correlation between negative priming and hypnotic suggestibility, using a different suggestibility measurement procedure that assessed subjective experience and hypnotic involuntariness as well as objective responses to suggestions. These studies support the notion that the ability to engage in cognitive inhibition may be an important component of hypnotic responsivity and maybe of other forms of suggestibility.

  19. Positions priming in briefly presented search arrays

    DEFF Research Database (Denmark)

    Asgeirsson, Arni Gunnar; Kristjánsson, Árni; Kyllingsbæk, Søren;

    2011-01-01

    Repetition priming in visual search has been a topic of extensive research since Maljkovic & Nakayama [1994, Memory & Cognition, 22, 657-672] presented the first detailed studies of such effects. Their results showed large reductions in reaction times when target color was repeated on consecutive...... pop-out search trials. Such repetition effects have since been generalized to a multitude of target attributes. Priming has primarily been investigated using self-terminating visual search paradigms, comparing differences in response times. Response accuracy has predominantly served as a control...... variable. Here we present results from experiments where position priming is demonstrated in paradigms involving temporally limited exposures to singleton targets. Position priming of response accuracy was observed in an eye-movement-controlled spatial judgment task and in partial report tasks where...

  20. Resistance of a gamma/gamma prime - delta directionally solidified eutectic alloy to recrystallization

    Science.gov (United States)

    Tewari, S. N.; Scheuermann, C. M.; Andrews, C. W.

    1975-01-01

    The lamellar directionally solidified nickel-base eutectic alloy gamma/gamma prime-delta has potential as an advanced turbine blade material. The microstructural stability of this alloy was investigated. Specimens were plastically deformed by uniform compression or Brinell indentation, then annealed between 705 and 1120 C. Microstructural changes observed after annealing included gamma prime coarsening, pinch-off and spheroidization of delta lamellae, and the appearance of an unidentified blocky phase in surface layers. All but the first of these was localized in severely deformed regions, suggesting that microstructural instability is not a serious problem in the use of this alloy.

  1. Degree of handedness and priming: further evidence for a distinction between production and identification priming mechanisms.

    Science.gov (United States)

    LaVoie, Donna J; Olbinski, Brianna; Palmer, Shayna

    2015-01-01

    The distinction between implicit and explicit forms of memory retrieval is long-standing, and important to the extent it reveals how different neural architecture supports different aspects of memory function. Similarly, distinctions have been made between kinds of repetition priming, a form of implicit memory retrieval. This study focuses on the production-identification (ID) priming distinction, which delineates priming tasks involving verification of stimulus features as compared to priming tasks that require use of a cue to guide response retrieval. Studies investigating this dissociation in dementia or similar patient populations indicate that these forms of priming may differ in their neural bases. The current study looks at degree of handedness as a way of investigating inferred neural architecture supporting these two forms of priming. A growing body of research indicates that degree of handedness (consistent, or CH, versus inconsistent, or ICH) is associated with greater interhemispheric interaction and functional access to right hemisphere processing in ICH, with superior performance seen in ICH on memory tasks reliant on this processing. Arguments about the theoretical mechanisms underlying ID and production forms of perceptual priming tasks suggest that performance on these tasks will differ as a function of degree of handedness. We tested this question in a group of CH and ICH young adults, who were asked to study lists of words prior to performing a production priming task (word stem completion, WSC), a perceptual word ID task, and a word stem cued recall task. While both handedness groups exhibited reliable priming across tasks, WSC priming was greater in ICH than CH participants, with ID priming not differing between groups. This dissociation supports the argument that production and ID forms of priming have different underlying neural bases.

  2. Masked Associative/Semantic Priming Effects across Languages with Highly Proficient Bilinguals

    Science.gov (United States)

    Perea, Manuel; Dunabeitia, Jon Andoni; Carreiras, Manuel

    2008-01-01

    One key issue for models of bilingual memory is to what degree the semantic representation from one of the languages is shared with the other language. In the present paper, we examine whether there is an early, automatic semantic priming effect across languages for noncognates with highly proficient (Basque/Spanish) bilinguals. Experiment 1 was a…

  3. Periodicity In The Intervals Between Primes

    Science.gov (United States)

    2015-07-02

    simple proportionality in Eq.(32), such that the basic form of Dc over the range (0,Γ] is repeated in progressively smaller scale over subsequent...striations are an aggregate visual effect that could be produced only from finely-grained periodicity in the δ- dependence of Dp. Figure (6) is a...a randomized analogue of the first 104 primes. indicates a certain ‘Russian dolls’-style self-similarity in the periodicity of the prime intervals

  4. Retro-priming, priming, and double testing: psi and replication in a test-retest design.

    Science.gov (United States)

    Rabeyron, Thomas

    2014-01-01

    Numerous experiments have been conducted in recent years on anomalous retroactive influences on cognition and affect (Bem, 2010), yet more data are needed to understand these processes precisely. For this purpose, we carried out an initial retro-priming study in which the response times of 162 participants were measured (Rabeyron and Watt, 2010). In the current paper, we present the results of a second study in which we selected those participants who demonstrated the strongest retro-priming effect during the first study, in order to see if we could replicate this effect and therefore select high scoring participants. An additional objective was to try to find correlations between psychological characteristics (anomalous experiences, mental health, mental boundaries, trauma, negative life events) and retro-priming results for the high scoring participants. The retro-priming effect was also compared with performance on a classical priming task. Twenty-eight participants returned to the laboratory for this new study. The results, for the whole group, on the retro-priming task, were negative and non-significant (es = -0.25, ns) and the results were significant on the priming task (es = 0.63, p priming results for all the sub-groups (students, male, female). Ten participants were found to have positive results on the two retro-priming studies, but no specific psychological variables were found for these participants compared to the others. Several hypotheses are considered in explaining these results, and the author provide some final thoughts concerning psi and replicability.

  5. Non-cognate translation priming in masked priming lexical decision experiments: A meta-analysis.

    Science.gov (United States)

    Wen, Yun; van Heuven, Walter J B

    2016-09-09

    The masked translation priming paradigm has been widely used in the last 25 years to investigate word processing in bilinguals. Motivated by studies reporting mixed findings, in particular for second language (L2) to first language (L1) translation priming, we conducted, for the first time in the literature, a meta-analysis of 64 masked priming lexical decision experiments across 24 studies to assess the effect sizes of L1-L2 and L2-L1 non-cognate translation priming effects in bilinguals. Our meta-analysis also investigated the influence of potential moderators of translation priming effects. The results provided clear evidence of significant translation priming effects for both directions, with L1-L2 translation priming significantly larger than L2-L1 translation priming (i.e., effect size of 0.86 vs. 0.31). The analyses also revealed that L1-L2 translation effect sizes were moderated by the interval between prime and target (ISI), whereas L2-L1 translation effect sizes were modulated by the number of items per cell. Theoretical and methodological implications of this meta-analysis are discussed and recommendations for future studies are provided.

  6. Semantic Priming for Coordinate Distant Concepts in Alzheimer's Disease Patients

    Science.gov (United States)

    Perri, R.; Zannino, G. D.; Caltagirone, C.; Carlesimo, G. A.

    2011-01-01

    Semantic priming paradigms have been used to investigate semantic knowledge in patients with Alzheimer's disease (AD). While priming effects produced by prime-target pairs with associative relatedness reflect processes at both lexical and semantic levels, priming effects produced by words that are semantically related but not associated should…

  7. Processing Speaker Variability in Repetition and Semantic/Associative Priming

    Science.gov (United States)

    Lee, Chao-Yang; Zhang, Yu

    2015-01-01

    The effect of speaker variability on accessing the form and meaning of spoken words was evaluated in two short-term priming experiments. In the repetition priming experiment, participants listened to repeated or unrelated prime-target pairs, in which the prime and target were produced by the same speaker or different speakers. The results showed…

  8. Processing Speaker Variability in Repetition and Semantic/Associative Priming

    Science.gov (United States)

    Lee, Chao-Yang; Zhang, Yu

    2015-01-01

    The effect of speaker variability on accessing the form and meaning of spoken words was evaluated in two short-term priming experiments. In the repetition priming experiment, participants listened to repeated or unrelated prime-target pairs, in which the prime and target were produced by the same speaker or different speakers. The results showed…

  9. Pure Mediated Priming: A Retrospective Semantic Matching Model

    Science.gov (United States)

    Jones, Lara L.

    2010-01-01

    Mediated priming refers to the activation of a target (e.g., "stripes") by a prime (e.g., "lion") that is related indirectly via a connecting mediator (e.g., tiger). In previous mediated priming studies (e.g., McNamara & Altarriba, 1988), the mediator was associatively related to the prime. In contrast, pure mediated…

  10. Semantic Priming for Coordinate Distant Concepts in Alzheimer's Disease Patients

    Science.gov (United States)

    Perri, R.; Zannino, G. D.; Caltagirone, C.; Carlesimo, G. A.

    2011-01-01

    Semantic priming paradigms have been used to investigate semantic knowledge in patients with Alzheimer's disease (AD). While priming effects produced by prime-target pairs with associative relatedness reflect processes at both lexical and semantic levels, priming effects produced by words that are semantically related but not associated should…

  11. Hyperthermia enhances CTL cross-priming.

    Science.gov (United States)

    Shi, Hongzhen; Cao, Tinghua; Connolly, John E; Monnet, Laurence; Bennett, Lynda; Chapel, Sylvie; Bagnis, Claude; Mannoni, Patrice; Davoust, Jean; Palucka, A Karolina; Banchereau, Jacques

    2006-02-15

    Dendritic cells (DCs) loaded with killed allogeneic melanoma cells can cross-prime naive CD8(+) T cells to differentiate into melanoma-specific CTLs in 3-wk cultures. In this study we show that DCs loaded with killed melanoma cells that were heated to 42 degrees C before killing are more efficient in cross-priming of naive CD8(+) T cells than DCs loaded with unheated killed melanoma cells. The enhanced cross-priming was demonstrated by several parameters: 1) induction of naive CD8(+) T cell differentiation in 2-wk cultures, 2) enhanced killing of melanoma peptide-pulsed T2 cells, 3) enhanced killing of HLA-A*0201(+) melanoma cells in a standard 4-h chromium release assay, and 4) enhanced capacity to prevent tumor growth in vitro in a tumor regression assay. Two mechanisms might explain the hyperthermia-induced enhanced cross-priming. First, heat-treated melanoma cells expressed increased levels of 70-kDa heat shock protein (HSP70), and enhanced cross-priming could be reproduced by overexpression of HSP70 in melanoma cells transduced with HSP70 encoding lentiviral vector. Second, hyperthermia resulted in the increased transcription of several tumor Ag-associated Ags, including MAGE-B3, -B4, -A8, and -A10. Thus, heat treatment of tumor cells permits enhanced cross-priming, possibly via up-regulation of both HSPs and tumor Ag expression.

  12. Components of competitor priming in task switching.

    Science.gov (United States)

    Teskey, Morgan L; Masson, Michael E J

    2017-07-17

    Executing an action in response to a stimulus is thought to result in the creation of an event code that integrates stimulus and action features (Allport, 1987; Hommel in Visual Cognition 5: 183-216, 1998). When switching between tasks, competitor priming occurs if a distractor stimulus cues the retrieval of a previously established event code in which that distractor is bound to a competing task, creating a source of interference with the current task whereby the observer is encouraged to apply the competing task to the distractor. We propose a second aspect of competitor priming: the misapplication of the retrieved competing task to the target stimulus. We report two task-switching experiments in which tasks applied to picture-word compound stimuli were manipulated to create conditions in which this second aspect of competitor priming could be revealed and distinguished from other sources of task- and stimulus-based priming. A substantial increase in competitor priming was observed when subjects switched between tasks that required very different processing operations and the competing task was highly relevant to the target stimulus. These results are consistent with our claim that competitor priming can result from applying the competing task either to the distractor that cued it or to the target stimulus.

  13. The priming effect of military service on creativity performance.

    Science.gov (United States)

    Chiu, Fa-Chung; Tu, Priscilla L P

    2014-04-01

    This study investigated the service priming effect on creativity performance. In three experiments, the service priming was manipulated in three ways (Army priming, Air Force priming, and a Neutral condition). Participants' performances on the Chinese Remote Associates Test (CRAT), insight problems, and critical thinking problems were accordingly measured in each experiment. Results showed that the Air Force priming improved creativity and the Army priming enhanced critical thinking. The results suggest that the constructions and processes of these two manipulations are different. In addition, results also suggested that the branch of military service moderates the relationship between the service priming and the performance of creativity.

  14. Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes.

    Science.gov (United States)

    Kimura, Tomohiko; Kaneto, Hideaki; Shimoda, Masashi; Hirukawa, Hidenori; Okauchi, Seizo; Kohara, Kenji; Hamamoto, Sumiko; Tawaramoto, Kazuhito; Hashiramoto, Mitsuru; Kaku, Kohei

    2015-01-15

    The aim was to compare the protective effects of pioglitazone (PIO) and/or liraglutide (LIRA) on β-cells with the progression of diabetes. Male db/db mice were treated with PIO and/or LIRA for 2 weeks in an early and advanced stage. In an early stage insulin biosynthesis and secretion were markedly increased by PIO and LIRA which was not observed in an advanced stage. In concomitant with such phenomena, expression levels of various β-cell-related factors were up-regulated by PIO and LIRA only in an early stage. Furthermore, β-cell mass was also increased by the treatment only in an early stage. Although there was no difference in apoptosis ratio between the two stages, β-cell proliferation was augmented by the treatment only in an early stage. In conclusion, protective effects of pioglitazone and/or liraglutide on β-cells were more powerful in an early stage of diabetes compared to an advanced stage.

  15. Neuroanatomic localization of priming effects for famous faces with latency-corrected event-related potentials.

    Science.gov (United States)

    Kashyap, Rajan; Ouyang, Guang; Sommer, Werner; Zhou, Changsong

    2016-02-01

    The late components of event-related brain potentials (ERPs) pose a difficult problem in source localization. One of the reasons is the smearing of these components in conventional averaging because of trial-to-trial latency-variability. The smearing problem may be addressed by reconstructing the ERPs after latency synchronization with the Residue Iteration Decomposition (RIDE) method. Here we assessed whether the benefits of RIDE at the surface level also improve source localization of RIDE-reconstructed ERPs (RERPs) measured in a face priming paradigm. Separate source models for conventionally averaged ERPs and RERPs were derived and sources were localized for both early and late components. Jackknife averaging on the data was used to reduce the residual variance during source localization compared to conventional source model fitting on individual subject data. Distances between corresponding sources of both ERP and RERP models were measured to check consistency in both source models. Sources for activity around P100, N170, early repetition effect (ERE/N250r) and late repetition effect (LRE/N400) were reported and priming effects in these sources were evaluated for six time windows. Significant improvement in priming effect of the late sources was found from the RERP source model, especially in the Medio-Temporal Lobe, Prefrontal Cortex, and Anterior Temporal Lobe. Consistent with previous studies, we found early priming effects in the right hemisphere and late priming effects in the left hemisphere. Also, the priming effects in right hemisphere outnumbered the left hemisphere, signifying dominance of right hemisphere in face recognition. In conclusion, RIDE reconstructed ERPs promise a comprehensive understanding of the time-resolved dynamics the late sources play during face recognition. Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Long and Short Term Cumulative Structural Priming Effects

    OpenAIRE

    Kaschak, Michael P.; Kutta, Timothy J.; Coyle, Jacqueline M.

    2012-01-01

    We present six experiments that examine cumulative structural priming effects (i.e., structural priming effects that accumulate across many utterances). Of particular interest is whether (1) cumulative priming effects transfer across language production tasks and (2) the transfer of cumulative priming effects across tasks persists over the course of a week. Our data suggest that cumulative structural priming effects do transfer across language production tasks (e.g., from written stem complet...

  17. Plant Heat Adaptation: priming in response to heat stress [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Isabel Bäurle

    2016-04-01

    Full Text Available Abiotic stress is a major threat to crop yield stability. Plants can be primed by heat stress, which enables them to subsequently survive temperatures that are lethal to a plant in the naïve state. This is a rapid response that has been known for many years and that is highly conserved across kingdoms. Interestingly, recent studies in Arabidopsis and rice show that this thermo-priming lasts for several days at normal growth temperatures and that it is an active process that is genetically separable from the priming itself. This is referred to as maintenance of acquired thermotolerance or heat stress memory. Such a memory conceivably has adaptive advantages under natural conditions, where heat stress often is chronic or recurring. In this review, I will focus on recent advances in the mechanistic understanding of heat stress memory.

  18. Rapid response learning of brand logo priming: Evidence that brand priming is not dominated by rapid response learning.

    Science.gov (United States)

    Boehm, Stephan G; Smith, Ciaran; Muench, Niklas; Noble, Kirsty; Atherton, Catherine

    2017-08-31

    Repetition priming increases the accuracy and speed of responses to repeatedly processed stimuli. Repetition priming can result from two complementary sources: rapid response learning and facilitation within perceptual and conceptual networks. In conceptual classification tasks, rapid response learning dominates priming of object recognition, but it does not dominate priming of person recognition. This suggests that the relative engagement of network facilitation and rapid response learning depends on the stimulus domain. Here, we addressed the importance of the stimulus domain for rapid response learning by investigating priming in another domain, brands. In three experiments, participants performed conceptual decisions for brand logos. Strong priming was present, but it was not dominated by rapid response learning. These findings add further support to the importance of the stimulus domain for the relative importance of network facilitation and rapid response learning, and they indicate that brand priming is more similar to person recognition priming than object recognition priming, perhaps because priming of both brands and persons requires individuation.

  19. Early Change in Metabolic Tumor Heterogeneity during Chemoradiotherapy and Its Prognostic Value for Patients with Locally Advanced Non-Small Cell Lung Cancer.

    Directory of Open Access Journals (Sweden)

    Xinzhe Dong

    Full Text Available To observe the early change of metabolic tumor heterogeneity during chemoradiotherapy and to determine its prognostic value for patients with locally advanced non-small cell lung cancer (NSCLC.From January 2007 to March 2010, 58 patients with NSCLC were included who were received 18F-fluorodeoxyglucose (18F-FDG PET/CT before and following 40 Gy radiotherapy with the concurrent cisplatin-based chemotherapy (CCRT. Primary tumor FDG uptake heterogeneity was determined using global and local scale textural features extracted from standardized uptake value (SUV histogram analysis (coefficient of variation [COV], skewness, kurtosis, area under the curve of the cumulative SUV histogram [AUC-CSH] and normalized gray-level co-occurrence matrix (contrast, dissimilarity, entropy, homogeneity. SUVmax and metabolic tumor volume (MTV were also evaluated. Correlations were analyzed between parameters on baseline or during treatments with tumor response, progression-free survival (PFS, and overall survival (OS.Compared with non-responders, responders showed significantly greater pre-treatment COV, contrast and MTV (AUC = 0.781, 0.804, 0.686, respectively. Receiver-operating-characteristic curve analysis showed that early change of tumor textural analysis serves as a response predictor with higher sensitivity (73.2%~92.1% and specificity (80.0%~83.6% than baseline parameters. Change in AUC-CSH and dissimilarity during CCRT could also predict response with optimal cut-off values (33.0% and 28.7%, respectively. The patients with greater changes in contrast and AUC-CSH had significantly higher 5-year OS (P = 0.008, P = 0.034 and PFS (P = 0.007, P = 0.039. In multivariate analysis, only change in contrast was found as the independent prognostic factor of PFS (HR 0.476, P = 0.021 and OS (HR 0.519, P = 0.015.The metabolic tumor heterogeneity change during CCRT characterized by global and local scale textural features may be valuable for predicting treatment response

  20. [SIB-IMRT radiotherapy given concomitantly with cisplatin for locally advanced squamous cell head and neck cancer (SCHNC). Evaluation of the early results and toxicity].

    Science.gov (United States)

    Kiprian, Dorota; Jarząbski, Andrzej; Pawłowska, Beata; Michalski, Wojciech; Kawecki, Andrzej

    2011-09-01

    Concomitant radiochemotherapy become the treatment of choice for locally advanced SCHNC. This strategy of treatment has a limitation, which is an acute and late toxicity. The IMRT technique provides the possibility of better sparing of healthy tissue. Radiobiological and clinical data also suggest that accelerated fractionation and higher dose per fraction given in GTV may produce better locoregional control. Therefore it might be expected that concomitant chemotherapy and SIB-IMRT radiotherapy could increase locoregional control and reduce acute and late radiation reactions. The evaluation of early results and toxicity of this treatment modality is presented. The evaluation of the early results and toxicity of SIB-IMRT radiotherapy given concomitantly with cisplatin for locally advanced squamous cell head and neck cancer (SCHNC). SIB-IMRT technique was applied. The boost volume was limited to the GTV + 3mm margin (macroscopic tumor extension was defined on the basis of CT and/or MRI examinations). Dose per fraction given to this volume was 2.25 Gy up to 67.5 Gy of total dose. The PTV-CTV + 3mm - was defined as an area of increased risk of microscopic spread. Dose per fraction given to this volume was 2 Gy up to 60 Gy. The PTV1-ETV+ 3mm (electively irradiated volume) received dose per fraction -1.8 Gy up to 54-56 Gy. Overall treatment time was 6 weeks (5 fractions per week, 30 fractions). Concomitant chemotherapy consisted of cisplatin in daily dose100mg/m2 given two times during irradiation (1 and 22 day of treatment). The evaluation of early tolerance was performed once weekly during the treatment than during the follow up every 2 months. The early reactions were scored according to the EORTC/RTOG scale. Between June 2006 and December 2009 99 patients diagnosed with III and IV clinical stage of SCHNC were treated with this method. 65 patients were diagnosed with oropharyngeal cancer, 18 with laryngeal cancer and 16 with hypopharyngeal cancer. PEG was performed at

  1. False memories and lexical decision: even twelve primes do not cause long-term semantic priming

    NARCIS (Netherlands)

    R. Zeelenberg (René); D. Pecher (Diane)

    2002-01-01

    textabstractSemantic priming effects are usually obtained only if the prime is presented shortly before the target stimulus. Recent evidence obtained with the so-called false memory paradigm suggests, however, that in both explicit and implicit memory tasks semantic relations between words can resul

  2. False memories and lexical decision: even twelve primes do not cause long-term semantic priming

    NARCIS (Netherlands)

    R. Zeelenberg (René); D. Pecher (Diane)

    2002-01-01

    textabstractSemantic priming effects are usually obtained only if the prime is presented shortly before the target stimulus. Recent evidence obtained with the so-called false memory paradigm suggests, however, that in both explicit and implicit memory tasks semantic relations between words

  3. Prime and prejudice: co-occurrence in the culture as a source of automatic stereotype priming.

    Science.gov (United States)

    Verhaeghen, Paul; Aikman, Shelley N; Van Gulick, Ana E

    2011-09-01

    It has been argued that stereotype priming (response times are faster for stereotypical word pairs, such as black-poor, than for non-stereotypical word pairs, such as black-balmy) is partially a function of biases in the belief system inherent in the culture. In three priming experiments, we provide direct evidence for this position, showing that stereotype priming effects associated with race, gender, and age can be very well explained through objectively measured associative co-occurrence of prime and target in the culture: (a) once objective associative strength between word pairs is taken into account, stereotype priming effects disappear; (b) the relationship between response time and associative strength is identical for social primes and non-social primes. The correlation between associative-value-controlled stereotype priming and self-report measures of racism, sexism, and ageism is near zero. The racist/sexist/ageist in all of us appears to be (at least partially) a reflection of the surrounding culture.

  4. The $\\eta^\\prime g^* g^{(*)}$ Vertex Including the $\\eta^\\prime$-Meson Mass

    CERN Document Server

    Ali, A

    2004-01-01

    The $\\eta^\\prime g^* g^{(*)}$ effective vertex function (EVF) is calculated in the QCD hard-scattering approach, taking into account the $\\eta^\\prime$-meson mass. We work in the approximation in which only one non-leading Gegenbauer moment in both the quark-antiquark and gluonic light-cone distribution amplitude for the $\\eta^\\prime$-meson is kept. The EVF with one off-shell gluon is shown to have the form $F_{\\eta^\\prime g^* g} (q_1^2, 0, m_{\\eta^\\prime}^2) = m_{\\eta^\\prime}^2 H(q_1^2)/(q_1^2 - m_{\\eta^\\prime}^2)$, valid for $|q_1^2| > m_{\\eta^\\prime}^2$. An interpolating formulae for the EVF in the space-like region of the virtuality $q_1^2$, which satisfies the QCD-anomaly normalization for on-shell gluons and the perturbative-QCD result for the gluon virtuality $|q_1^2| \\gtrsim 2 GeV^2$, is also presented.

  5. Smelly primes – when olfactory primes do or do not work

    Directory of Open Access Journals (Sweden)

    Monique A Smeets

    2014-02-01

    Full Text Available In applied olfactory cognition the effects that olfactory stimulation can have on (human behavior are investigated. To enable an efficient application of olfactory stimuli a model of how they may lead to a change in behavior is proposed. To this end we use the concept of olfactory priming. Olfactory priming may prompt a special view on priming as the olfactory sense has some unique properties which make odors special types of primes. Examples of such properties are the ability of odors to influence our behavior outside of awareness, to lead to strong affective evaluations, to evoke specific memories, and to associate easily and quickly to other environmental stimuli. Opportunities and limitations for using odors as primes are related to these properties, and alternative explanations for reported findings are offered. Implications for olfactory semantic, construal, behavior and goal priming are given based on a brief overview of the priming literature from social psychology and from olfactory perception science. We end by formulating recommendations and ideas for a future research agenda and applications for olfactory priming.

  6. Correlation of early PET findings with tumor response to molecular targeted agents in patients with advanced driver-mutated non-small cell lung cancer.

    Science.gov (United States)

    Koizumi, Tomonobu; Fukushima, Toshirou; Gomi, Daisuke; Kobayashi, Takashi; Sekiguchi, Nodoka; Mamiya, Keiko; Tateishi, Kazunari; Katou, Akane; Oguchi, Kazuhiro

    2017-09-01

    Recent advances in positron emission tomography with fluorine-18-fluorodeoxyglucose (FDG-PET) have facilitated not only the diagnosis and staging of lung cancer, but also the prediction of treatment outcome. The present study was designed to assess the usefulness of early FDG-PET examination for predicting subsequent tumor size reduction in response to molecular targeted agents in metastatic non-small cell lung cancer (NSCLC) with sensitive gene anomalies. I. In 29 targeted lesions of 10 NSCLC patients, changes in FDG uptake before and on day 7 after the initiation of molecular targeted therapy (gefitinib, n = 7; crizotinib, n = 3) were compared with subsequent radiographic tumor size reduction by RECIST. FDG uptake was evaluated as the maximum standardized uptake value (SUVmax) of each targeted lesion. SUVmax decreased in all lesions after therapy (mean SUVmax 8.3 ± 3.4 before to 3.7 ± 1.8 after therapy, p < 0.05). The % decrease in SUVmax of each lesion was significantly correlated with the % tumor size reduction (r = 0.44). In addition, the reduction rate of SUVmax in metastatic bone lesions after initiation of molecular targeted therapy was significantly lower than that in targeted organs (27.1 ± 27.5 vs. 51.2 ± 21.3%, respectively, p < 0.05). Early reduction in FDG-PET uptake after initiation of molecular targeted agents was able to predict subsequent tumor reduction in patients harboring EGFR-mutated or ALK-positive NSCLC. In addition, nontargeted bone metastasis may have different glucose metabolism after TKI treatment compared with other involved organs.

  7. Advanced urology nursing practice.

    Science.gov (United States)

    Crowe, Helen

    2014-03-01

    Urology nursing has developed as a specialty over the past few decades in response to several factors, workload demands being a prime reason. Nurses are taking on additional roles and activities including procedures such as cystoscopy and prostate biopsy, and running nurse-led clinics for a variety of urological conditions. Audits of advanced urological nursing practice have shown this care to be of a high standard and investigative procedures performed by these nurses match the diagnostic quality of existing services. Professional urological nursing organizations support the professional needs of these nurses, but the provision of education and training for advanced practice activities remains an unaddressed need. A range of confusing advanced urology nursing titles exists, and uncertainty regarding the roles and scope of practice for these nurses remains a concern. Acceptance and support from medical colleagues is required for the success of advanced urological nursing practice, but opinions on these roles remain divided.

  8. A Single-System Model Predicts Recognition Memory and Repetition Priming in Amnesia

    Science.gov (United States)

    Kessels, Roy P.C.; Wester, Arie J.; Shanks, David R.

    2014-01-01

    We challenge the claim that there are distinct neural systems for explicit and implicit memory by demonstrating that a formal single-system model predicts the pattern of recognition memory (explicit) and repetition priming (implicit) in amnesia. In the current investigation, human participants with amnesia categorized pictures of objects at study and then, at test, identified fragmented versions of studied (old) and nonstudied (new) objects (providing a measure of priming), and made a recognition memory judgment (old vs new) for each object. Numerous results in the amnesic patients were predicted in advance by the single-system model, as follows: (1) deficits in recognition memory and priming were evident relative to a control group; (2) items judged as old were identified at greater levels of fragmentation than items judged new, regardless of whether the items were actually old or new; and (3) the magnitude of the priming effect (the identification advantage for old vs new items) overall was greater than that of items judged new. Model evidence measures also favored the single-system model over two formal multiple-systems models. The findings support the single-system model, which explains the pattern of recognition and priming in amnesia primarily as a reduction in the strength of a single dimension of memory strength, rather than a selective explicit memory system deficit. PMID:25122896

  9. Priming intelligent behavior: an elusive phenomenon.

    Directory of Open Access Journals (Sweden)

    David R Shanks

    Full Text Available Can behavior be unconsciously primed via the activation of attitudes, stereotypes, or other concepts? A number of studies have suggested that such priming effects can occur, and a prominent illustration is the claim that individuals' accuracy in answering general knowledge questions can be influenced by activating intelligence-related concepts such as professor or soccer hooligan. In 9 experiments with 475 participants we employed the procedures used in these studies, as well as a number of variants of those procedures, in an attempt to obtain this intelligence priming effect. None of the experiments obtained the effect, although financial incentives did boost performance. A Bayesian analysis reveals considerable evidential support for the null hypothesis. The results conform to the pattern typically obtained in word priming experiments in which priming is very narrow in its generalization and unconscious (subliminal influences, if they occur at all, are extremely short-lived. We encourage others to explore the circumstances in which this phenomenon might be obtained.

  10. A computational approach to negative priming

    Science.gov (United States)

    Schrobsdorff, H.; Ihrke, M.; Kabisch, B.; Behrendt, J.; Hasselhorn, M.; Herrmann, J. Michael

    2007-09-01

    Priming is characterized by a sensitivity of reaction times to the sequence of stimuli in psychophysical experiments. The reduction of the reaction time observed in positive priming is well-known and experimentally understood (Scarborough et al., J. Exp. Psycholol: Hum. Percept. Perform., 3, pp. 1-17, 1977). Negative priming—the opposite effect—is experimentally less tangible (Fox, Psychonom. Bull. Rev., 2, pp. 145-173, 1995). The dependence on subtle parameter changes (such as response-stimulus interval) usually varies. The sensitivity of the negative priming effect bears great potential for applications in research in fields such as memory, selective attention, and ageing effects. We develop and analyse a computational realization, CISAM, of a recent psychological model for action decision making, the ISAM (Kabisch, PhD thesis, Friedrich-Schiller-Universitat, 2003), which is sensitive to priming conditions. With the dynamical systems approach of the CISAM, we show that a single adaptive threshold mechanism is sufficient to explain both positive and negative priming effects. This is achieved by comparing results obtained by the computational modelling with experimental data from our laboratory. The implementation provides a rich base from which testable predictions can be derived, e.g. with respect to hitherto untested stimulus combinations (e.g. single-object trials).

  11. Affective Priming in Major Depressive Disorder

    Directory of Open Access Journals (Sweden)

    Joelle eLeMoult

    2012-10-01

    Full Text Available Research on cognitive biases in depression has provided considerable evidence for the impact of emotion on cognition. Individuals with depression tend to preferentially process mood-congruent material and to show deficits in the processing of positive material leading to biases in attention, memory, and judgments. More research is needed, however, to fully understand which cognitive processes are affected. The current study further examines the impact of emotion on cognition using a priming design with facial expressions of emotion. Specifically, this study tested whether the presentation of facial expressions of emotion affects subsequent processing of affective material in participants with major depressive disorder (MDD and healthy controls (CTL. Facial expressions displaying happy, sad, angry, disgusted, or neutral expressions were presented as primes for 500ms, and participants’ speed to identify a subsequent target’s emotional expression was assessed. All participants displayed greater interference from emotional versus neutral primes, marked by slower response times to judge the emotion of the target face when it was preceded by an emotional prime. Importantly, the CTL group showed the strongest interference when happy emotional expressions served as primes whereas the MDD group failed to show this bias. These results add to a growing literature that shows that depression is associated with difficulties in the processing of positive material.

  12. Priming for novel object associations: Neural differences from object item priming and equivalent forms of recognition.

    Science.gov (United States)

    Gomes, Carlos Alexandre; Figueiredo, Patrícia; Mayes, Andrew

    2016-04-01

    The neural substrates of associative and item priming and recognition were investigated in a functional magnetic resonance imaging study over two separate sessions. In the priming session, participants decided which object of a pair was bigger during both study and test phases. In the recognition session, participants saw different object pairs and performed the same size-judgement task followed by an associative recognition memory task. Associative priming was accompanied by reduced activity in the right middle occipital gyrus as well as in bilateral hippocampus. Object item priming was accompanied by reduced activity in extensive priming-related areas in the bilateral occipitotemporofrontal cortex, as well as in the perirhinal cortex, but not in the hippocampus. Associative recognition was characterized by activity increases in regions linked to recollection, such as the hippocampus, posterior cingulate cortex, anterior medial frontal gyrus and posterior parahippocampal cortex. Item object priming and recognition recruited broadly overlapping regions (e.g., bilateral middle occipital and prefrontal cortices, left fusiform gyrus), even though the BOLD response was in opposite directions. These regions along with the precuneus, where both item priming and recognition were accompanied by activation, have been found to respond to object familiarity. The minimal structural overlap between object associative priming and recollection-based associative recognition suggests that they depend on largely different stimulus-related information and that the different directions of the effects indicate distinct retrieval mechanisms. In contrast, item priming and familiarity-based recognition seemed mainly based on common memory information, although the extent of common processing between priming and familiarity remains unclear. Further implications of these findings are discussed.

  13. Researches on the Nankai trough mega thrust earthquake seismogenic zones using real time observing systems for advanced early warning systems and predictions

    Science.gov (United States)

    Kaneda, Yoshiyuki

    2015-04-01

    We recognized the importance of real time monitoring on Earthquakes and Tsunamis Based on lessons learned from 2004 Sumatra Earthquake/Tsunamis and 2011 East Japan Earthquake. We deployed DONET1 and are developing DONET2 as real time monitoring systems which are dense ocean floor networks around the Nankai trough seismogenic zone Southwestern Japan. Total observatories of DONE1 and DONET2 are 51 observatories equipped with multi kinds of sensors such as the accelerometer, broadband seismometer, pressure gauge, difference pressure gauge, hydrophone and thermometer in each observatory. These systems are indispensable for not only early warning of Earthquakes/ Tsunamis, but also researches on broadband crustal activities around the Nankai trough seismogenic zone for predictions. DONET1 detected offshore tsunamis 15 minutes earlier than onshore stations at the 2011 East Japan earthquake/tsunami. Furthermore, DONET1/DONET2 will be expected to monitor slow events such as low frequency tremors and slow earthquakes for the prediction researches. Finally, the integration of observations and simulation researches will contribute to estimate of seismic stage changes from the inter-seismic to pre seismic stage. I will introduce applications of DONET1/DONET2 data and advanced simulation researches.

  14. Bioinformatics Analysis Reveals Distinct Molecular Characteristics of Hepatitis B-Related Hepatocellular Carcinomas from Very Early to Advanced Barcelona Clinic Liver Cancer Stages.

    Directory of Open Access Journals (Sweden)

    Fan-Yun Kong

    Full Text Available Hepatocellular carcinoma (HCCis the fifth most common malignancy associated with high mortality. One of the risk factors for HCC is chronic hepatitis B virus (HBV infection. The treatment strategy for the disease is dependent on the stage of HCC, and the Barcelona clinic liver cancer (BCLC staging system is used in most HCC cases. However, the molecular characteristics of HBV-related HCC in different BCLC stages are still unknown. Using GSE14520 microarray data from HBV-related HCC cases with BCLC stages from 0 (very early stage to C (advanced stage in the gene expression omnibus (GEO database, differentially expressed genes (DEGs, including common DEGs and unique DEGs in different BCLC stages, were identified. These DEGs were located on different chromosomes. The molecular functions and biology pathways of DEGs were identified by gene ontology (GO analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG pathway analysis, and the interactome networks of DEGs were constructed using the NetVenn online tool. The results revealed that both common DEGs and stage-specific DEGs were associated with various molecular functions and were involved in special biological pathways. In addition, several hub genes were found in the interactome networks of DEGs. The identified DEGs and hub genes promote our understanding of the molecular mechanisms underlying the development of HBV-related HCC through the different BCLC stages, and might be used as staging biomarkers or molecular targets for the treatment of HCC with HBV infection.

  15. Bioinformatics Analysis Reveals Distinct Molecular Characteristics of Hepatitis B-Related Hepatocellular Carcinomas from Very Early to Advanced Barcelona Clinic Liver Cancer Stages

    Science.gov (United States)

    Hu, Wei; Kou, Yan-Bo; You, Hong-Juan; Liu, Xiao-Mei; Zheng, Kui-Yang; Tang, Ren-Xian

    2016-01-01

    Hepatocellular carcinoma (HCC)is the fifth most common malignancy associated with high mortality. One of the risk factors for HCC is chronic hepatitis B virus (HBV) infection. The treatment strategy for the disease is dependent on the stage of HCC, and the Barcelona clinic liver cancer (BCLC) staging system is used in most HCC cases. However, the molecular characteristics of HBV-related HCC in different BCLC stages are still unknown. Using GSE14520 microarray data from HBV-related HCC cases with BCLC stages from 0 (very early stage) to C (advanced stage) in the gene expression omnibus (GEO) database, differentially expressed genes (DEGs), including common DEGs and unique DEGs in different BCLC stages, were identified. These DEGs were located on different chromosomes. The molecular functions and biology pathways of DEGs were identified by gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and the interactome networks of DEGs were constructed using the NetVenn online tool. The results revealed that both common DEGs and stage-specific DEGs were associated with various molecular functions and were involved in special biological pathways. In addition, several hub genes were found in the interactome networks of DEGs. The identified DEGs and hub genes promote our understanding of the molecular mechanisms underlying the development of HBV-related HCC through the different BCLC stages, and might be used as staging biomarkers or molecular targets for the treatment of HCC with HBV infection. PMID:27454179

  16. Transient terahertz photoconductivity measurements of minority-carrier lifetime in tin sulfide thin films: Advanced metrology for an early stage photovoltaic material

    Science.gov (United States)

    Jaramillo, R.; Sher, Meng-Ju; Ofori-Okai, Benjamin K.; Steinmann, V.; Yang, Chuanxi; Hartman, Katy; Nelson, Keith A.; Lindenberg, Aaron M.; Gordon, Roy G.; Buonassisi, T.

    2016-01-01

    Materials research with a focus on enhancing the minority-carrier lifetime of the light-absorbing semiconductor is key to advancing solar energy technology for both early stage and mature material platforms alike. Tin sulfide (SnS) is an absorber material with several clear advantages for manufacturing and deployment, but the record power conversion efficiency remains below 5%. We report measurements of bulk and interface minority-carrier recombination rates in SnS thin films using optical-pump, terahertz-probe transient photoconductivity (TPC) measurements. Post-growth thermal annealing in H2S gas increases the minority-carrier lifetime, and oxidation of the surface reduces the surface recombination velocity. However, the minority-carrier lifetime remains below 100 ps for all tested combinations of growth technique and post-growth processing. Significant improvement in SnS solar cell performance will hinge on finding and mitigating as-yet-unknown recombination-active defects. We describe in detail our methodology for TPC experiments, and we share our data analysis routines in the form freely available software.

  17. The Marine Biological Laboratory (Woods Hole) and the scientific advancement of women in the early 20th century: the example of Mary Jane Hogue (1883-1962).

    Science.gov (United States)

    Zottoli, Steven J; Seyfarth, Ernst-August

    2015-01-01

    The Marine Biological Laboratory (MBL) in Woods Hole, MA provided opportunities for women to conduct research in the late 19th and early 20th century at a time when many barriers existed to their pursuit of a scientific career. One woman who benefited from the welcoming environment at the MBL was Mary Jane Hogue. Her remarkable career as an experimental biologist spanned over 55 years. Hogue was born into a Quaker family in 1883 and received her undergraduate degree from Goucher College. She went to Germany to obtain an advanced degree, and her research at the University of Würzburg with Theodor Boveri resulted in her Ph.D. (1909). Although her research interests included experimental embryology, and the use of tissue culture to study a variety of cell types, she is considered foremost a protozoologist. Her extraordinary demonstration of chromidia (multiple fission) in the life history of a new species of Flabellula associated with diseased oyster beds is as important as it is ignored. We discuss Hogue's career path and her science to highlight the importance of an informal network of teachers, research advisors, and other women scientists at the MBL all of whom contributed to her success as a woman scientist.

  18. Priming effects of a peripheral visual stimulus in simple and go/no-go tasks

    Directory of Open Access Journals (Sweden)

    S.A.F. Squella

    2003-02-01

    Full Text Available The early facilitatory effect of a peripheral spatially visual prime stimulus described in the literature for simple reaction time tasks has been usually smaller than that described for complex (go/no-go, choice reaction time tasks. In the present study we investigated the reason for this difference. In a first and a second experiment we tested the participants in both a simple task and a go/no-go task, half of them beginning with one of these tasks and half with the other one. We observed that the prime stimulus had an early effect, inhibitory for the simple task and facilitatory for the go/no-go task, when the task was performed first. No early effect appeared when the task was performed second. In a third and a fourth experiment the participants were, respectively, tested in the simple task and in the go/no-go task for four sessions (the prime stimulus was presented in the second, third and fourth sessions. The early effects of the prime stimulus did not change across the sessions, suggesting that a habituatory process was not the cause for the disappearance of these effects in the first two experiments. Our findings are compatible with the idea that different attentional strategies are adopted in simple and complex reaction time tasks. In the former tasks the gain of automatic attention mechanisms may be adjusted to a low level and in the latter tasks, to a high level. The attentional influence of the prime stimulus may be antagonized by another influence, possibly a masking one.

  19. Priming effects of a peripheral visual stimulus in simple and go/no-go tasks.

    Science.gov (United States)

    Squella, S A F; Ribeiro-Do-Valle, L E

    2003-02-01

    The early facilitatory effect of a peripheral spatially visual prime stimulus described in the literature for simple reaction time tasks has been usually smaller than that described for complex (go/no-go, choice) reaction time tasks. In the present study we investigated the reason for this difference. In a first and a second experiment we tested the participants in both a simple task and a go/no-go task, half of them beginning with one of these tasks and half with the other one. We observed that the prime stimulus had an early effect, inhibitory for the simple task and facilitatory for the go/no-go task, when the task was performed first. No early effect appeared when the task was performed second. In a third and a fourth experiment the participants were, respectively, tested in the simple task and in the go/no-go task for four sessions (the prime stimulus was presented in the second, third and fourth sessions). The early effects of the prime stimulus did not change across the sessions, suggesting that a habituatory process was not the cause for the disappearance of these effects in the first two experiments. Our findings are compatible with the idea that different attentional strategies are adopted in simple and complex reaction time tasks. In the former tasks the gain of automatic attention mechanisms may be adjusted to a low level and in the latter tasks, to a high level. The attentional influence of the prime stimulus may be antagonized by another influence, possibly a masking one.

  20. Affective priming using facial expressions modulates liking for abstract art.

    Directory of Open Access Journals (Sweden)

    Albert Flexas

    Full Text Available We examined the influence of affective priming on the appreciation of abstract artworks using an evaluative priming task. Facial primes (showing happiness, disgust or no emotion were presented under brief (Stimulus Onset Asynchrony, SOA = 20 ms and extended (SOA = 300 ms conditions. Differences in aesthetic liking for abstract paintings depending on the emotion expressed in the preceding primes provided a measure of the priming effect. The results showed that, for the extended SOA, artworks were liked more when preceded by happiness primes and less when preceded by disgust primes. Facial expressions of happiness, though not of disgust, exerted similar effects in the brief SOA condition. Subjective measures and a forced-choice task revealed no evidence of prime awareness in the suboptimal condition. Our results are congruent with findings showing that the affective transfer elicited by priming biases evaluative judgments, extending previous research to the domain of aesthetic appreciation.

  1. Affective Priming Using Facial Expressions Modulates Liking for Abstract Art

    Science.gov (United States)

    Flexas, Albert; Rosselló, Jaume; Christensen, Julia F.; Nadal, Marcos; Olivera La Rosa, Antonio; Munar, Enric

    2013-01-01

    We examined the influence of affective priming on the appreciation of abstract artworks using an evaluative priming task. Facial primes (showing happiness, disgust or no emotion) were presented under brief (Stimulus Onset Asynchrony, SOA = 20ms) and extended (SOA = 300ms) conditions. Differences in aesthetic liking for abstract paintings depending on the emotion expressed in the preceding primes provided a measure of the priming effect. The results showed that, for the extended SOA, artworks were liked more when preceded by happiness primes and less when preceded by disgust primes. Facial expressions of happiness, though not of disgust, exerted similar effects in the brief SOA condition. Subjective measures and a forced-choice task revealed no evidence of prime awareness in the suboptimal condition. Our results are congruent with findings showing that the affective transfer elicited by priming biases evaluative judgments, extending previous research to the domain of aesthetic appreciation. PMID:24260350

  2. The role of short-term memory in semantic priming.

    Science.gov (United States)

    Beer, A L; Diehl, V A

    2001-07-01

    Two theories of priming were compared: spreading activation theories, in particular ACT, and compound-cue theories. Whereas ACT assumes that priming is a result of diffusing activation in long-term memory, compound-cue models suggest that priming results from a formation process of prime and target in short-term memory. Thirty-eight participants took part in a study that combined a digit span task with a double lexical decision task consisting of a prime and a target item. Digit span length (low, medium, and high) and prime type (related or unrelated word or nonword) were both within-subject variables. As expected, results showed significant priming effects. In favor of ACT, no interaction between digit span length and prime type was found. Additionally, a nonword inhibition effect (unrelated versus nonword prime) was found, which was predicted by compound-cue theories. This finding is discussed in terms of the process interference and response competition hypotheses.

  3. Schoolbook Texts: Behavioral Achievement Priming in Math and Language.

    Science.gov (United States)

    Engeser, Stefan; Baumann, Nicola; Baum, Ingrid

    2016-01-01

    Prior research found reliable and considerably strong effects of semantic achievement primes on subsequent performance. In order to simulate a more natural priming condition to better understand the practical relevance of semantic achievement priming effects, running texts of schoolbook excerpts with and without achievement primes were used as priming stimuli. Additionally, we manipulated the achievement context; some subjects received no feedback about their achievement and others received feedback according to a social or individual reference norm. As expected, we found a reliable (albeit small) positive behavioral priming effect of semantic achievement primes on achievement in math (Experiment 1) and language tasks (Experiment 2). Feedback moderated the behavioral priming effect less consistently than we expected. The implication that achievement primes in schoolbooks can foster performance is discussed along with general theoretical implications.

  4. Affective priming using facial expressions modulates liking for abstract art.

    Science.gov (United States)

    Flexas, Albert; Rosselló, Jaume; Christensen, Julia F; Nadal, Marcos; Olivera La Rosa, Antonio; Munar, Enric

    2013-01-01

    We examined the influence of affective priming on the appreciation of abstract artworks using an evaluative priming task. Facial primes (showing happiness, disgust or no emotion) were presented under brief (Stimulus Onset Asynchrony, SOA = 20 ms) and extended (SOA = 300 ms) conditions. Differences in aesthetic liking for abstract paintings depending on the emotion expressed in the preceding primes provided a measure of the priming effect. The results showed that, for the extended SOA, artworks were liked more when preceded by happiness primes and less when preceded by disgust primes. Facial expressions of happiness, though not of disgust, exerted similar effects in the brief SOA condition. Subjective measures and a forced-choice task revealed no evidence of prime awareness in the suboptimal condition. Our results are congruent with findings showing that the affective transfer elicited by priming biases evaluative judgments, extending previous research to the domain of aesthetic appreciation.

  5. Graded effects of regularity in language revealed by N400 indices of morphological priming.

    Science.gov (United States)

    Kielar, Aneta; Joanisse, Marc F

    2010-07-01

    Differential electrophysiological effects for regular and irregular linguistic forms have been used to support the theory that grammatical rules are encoded using a dedicated cognitive mechanism. The alternative hypothesis is that language systematicities are encoded probabilistically in a way that does not categorically distinguish rule-like and irregular forms. In the present study, this matter was investigated more closely by focusing specifically on whether the regular-irregular distinction in English past tenses is categorical or graded. We compared the ERP priming effects of regulars (baked-bake), vowel-change irregulars (sang-sing), and "suffixed" irregulars that display a partial regularity (suffixed irregular verbs, e.g., slept-sleep), as well as forms that are related strictly along formal or semantic dimensions. Participants performed a visual lexical decision task with either visual (Experiment 1) or auditory prime (Experiment 2). Stronger N400 priming effects were observed for regular than vowel-change irregular verbs, whereas suffixed irregulars tended to group with regular verbs. Subsequent analyses decomposed early versus late-going N400 priming, and suggested that differences among forms can be attributed to the orthographic similarity of prime and target. Effects of morphological relatedness were observed in the later-going time period, however, we failed to observe true regular-irregular dissociations in either experiment. The results indicate that morphological effects emerge from the interaction of orthographic, phonological, and semantic overlap between words.

  6. Crosslinguistic semantic and translation priming in normal bilingual individuals and bilingual aphasia.

    Science.gov (United States)

    Kiran, Swathi; Lebel, Keith R

    2007-04-01

    The present study examined lexical representation in early Spanish-English bilinguals using an unmasked semantic and translation priming paradigm. In Experiment 1, participants were divided into two groups based on performance (more-balanced bilinguals, MB and less-balanced bilinguals, LB) on the experimental task. In Experiment 2, four patients with bilingual aphasia (BA) performed the same experiment. Results from both experiments revealed that all groups were more accurate for English targets (S-E direction) than Spanish targets (S-E direction). In Experiment 1, semantic priming was observed from English to Spanish in both the LB and MB groups although the effect was greater for the LB group. Further, only the LB group showed priming from Spanish to English. For both normal groups, there was no difference between translation and semantic priming effects. In Experiment 2, patients with bilingual aphasia demonstrated different patterns of activation with no clear trends. Two participants demonstrated greater priming from Spanish to English whereas two participants demonstrated the opposite effect.

  7. Riemann zeros, prime numbers, and fractal potentials.

    Science.gov (United States)

    van Zyl, Brandon P; Hutchinson, David A W

    2003-06-01

    Using two distinct inversion techniques, the local one-dimensional potentials for the Riemann zeros and prime number sequence are reconstructed. We establish that both inversion techniques, when applied to the same set of levels, lead to the same fractal potential. This provides numerical evidence that the potential obtained by inversion of a set of energy levels is unique in one dimension. We also investigate the fractal properties of the reconstructed potentials and estimate the fractal dimensions to be D=1.5 for the Riemann zeros and D=1.8 for the prime numbers. This result is somewhat surprising since the nearest-neighbor spacings of the Riemann zeros are known to be chaotically distributed, whereas the primes obey almost Poissonlike statistics. Our findings show that the fractal dimension is dependent on both level statistics and spectral rigidity, Delta(3), of the energy levels.

  8. Prime Minister of Pakistan visits CERN

    CERN Multimedia

    Anaïs Schaeffer

    2016-01-01

    On Saturday, 23 January 2016, CERN welcomed Mr Muhammad Nawaz Sharif, Prime Minister of Pakistan.   From left to right: Minister of Finance Mr Mohammad Ishaq Dar, Prime Minister of the Islamic Republic of Pakistan, Muhammad Nawaz Sharif, CERN Director-General Fabiola Gianotti and CMS national contact physicist Hafeez Hoorani. Mr Muhammad Nawaz Sharif arrived at Point 5 in Cessy, where he was welcomed onto French soil by the sous-préfet of Cessy, Stéphane Donnot, and, representing CERN, Director-General Fabiola Gianotti, Directors Eckhard Elsen and Charlotte Warakaulle, and Rüdiger Voss, the adviser for relations with Pakistan. It was the first visit by a head of government of Pakistan since the country became CERN's latest Associate Member State in July 2015. The Prime Minister then had the opportunity to visit the CMS underground experimental area accompanied by the CMS Spokesperson, Tiziano Camporesi, and the CMS collaboration’...

  9. Masked emotional priming beyond global valence activations.

    Science.gov (United States)

    Rohr, Michaela; Degner, Juliane; Wentura, Dirk

    2012-01-01

    An immense body of research demonstrates that emotional facial expressions can be processed unconsciously. However, it has been assumed that such processing takes place solely on a global valence-based level, allowing individuals to disentangle positive from negative emotions but not the specific emotion. In three studies, we investigated the specificity of emotion processing under conditions of limited awareness using a modified variant of an affective priming task. Faces with happy, angry, sad, fearful, and neutral expressions were presented as masked primes for 33 ms (Study 1) or 14 ms (Studies 2 and 3) followed by emotional target faces (Studies 1 and 2) or emotional adjectives (Study 3). Participants' task was to categorise the target emotion. In all three studies, discrimination of targets was significantly affected by the emotional primes beyond a simple positive versus negative distinction. Results indicate that specific aspects of emotions might be automatically disentangled in addition to valence, even under conditions of subjective unawareness.

  10. Prime factorization using magnonic holographic devices

    Science.gov (United States)

    Khivintsev, Yuri; Ranjbar, Mojtaba; Gutierrez, David; Chiang, Howard; Kozhevnikov, Alexander; Filimonov, Yuri; Khitun, Alexander

    2016-09-01

    Determining the prime factors of a given number N is a problem that requires super-polynomial time for conventional digital computers. A polynomial-time algorithm was invented by Shor for quantum computers. In this paper, we present experimental data that demonstrate prime factorization using spin-wave interference but without quantum entanglement. Prime factorization includes three major steps. First, a general-type computer calculates the sequence of numbers mkmod(N), where N is the number to be factorized, m is a randomly chosen positive integer, and k = 1, 2, 3, 4, 5, 6…. Next, the period of the calculated sequence r is determined by exploiting spin-wave interference. Finally, the general-type computer determines the primes based on the obtained r. The experiment for period finding was conducted on a six-terminal Y3Fe2(FeO4)3 device. We chose number 15 for testing and determined its primes using a sequence of measurements. The obtained experimental data for a micrometer-sized prototype aimed to demonstrate the benefits of using spin-wave devices to solve complex computational problems. Scalability is one of the major strengths inherent in this type of wave-based device, which may provide a route to nanometer-sized logic circuits. We discuss the physical and technological limitations of this approach, which define the maximum size of N and the computational speed. Although this classical approach cannot compete with the quantum algorithm in terms of efficiency, magnonic holographic devices can potentially be used as complementary logic units aimed at speeding up prime factorization for classical computers.

  11. Acceleration Detection of Large (Probably Prime Numbers

    Directory of Open Access Journals (Sweden)

    Dragan Vidakovic

    2013-02-01

    Full Text Available In order to avoid unnecessary applications of Miller-Rabin algorithm to the number in question, we resortto trial division by a few initial prime numbers, since such a division take less time. How far we should gowith such a division is the that we are trying to answer in this paper?For the theory of the matter is fullyresolved. However, that in practice we do not have much use.Therefore, we present a solution that isprobably irrelevant to theorists, but it is very useful to people who have spent many nights to producelarge (probably prime numbers using its own software.

  12. Exponential sums over primes in short intervals

    Institute of Scientific and Technical Information of China (English)

    LIU Jianya; L(U) Guangshi; ZHAN Tao

    2006-01-01

    In this paper we establish one new estimate on exponential sums over primes in short intervals. As an application of this result, we sharpen Hua's result by proving that each sufficiently large integer N congruent to 5 modulo 24 can be written as N = p21 +p22 +p23 +p24 +p25, with |pj - √N/5| ≤ U = N1/2-1/20+ε,where pj are primes. This result is as good as what one can obtain from the generalized Riemann hypothesis.

  13. On a Class of Prime Entire Functions

    Institute of Scientific and Technical Information of China (English)

    Kuldeep Singh CHARAK; Ilpo LAINE

    2009-01-01

    In this note it is proved that entire functions of the form Fa(z) = H(z)-aα(z),where H and α are entire functions, with α having at least one zero, H' and α' having no common zeros and T(r, α) = S(T, H), are prime in entire sense for most values of α. The class of these functions is seen to contain examples of both periodic and non-periodic prime entire functions found by Noda,Qiao, Urabe and by Singh and Charak. Another result due to Singh and Charak will be improved as well.

  14. The roles of scene priming and location priming in object-scene consistency effects.

    Science.gov (United States)

    Heise, Nils; Ansorge, Ulrich

    2014-01-01

    Presenting consistent objects in scenes facilitates object recognition as compared to inconsistent objects. Yet the mechanisms by which scenes influence object recognition are still not understood. According to one theory, consistent scenes facilitate visual search for objects at expected places. Here, we investigated two predictions following from this theory: If visual search is responsible for consistency effects, consistency effects could be weaker (1) with better-primed than less-primed object locations, and (2) with less-primed than better-primed scenes. In Experiments 1 and 2, locations of objects were varied within a scene to a different degree (one, two, or four possible locations). In addition, object-scene consistency was studied as a function of progressive numbers of repetitions of the backgrounds. Because repeating locations and backgrounds could facilitate visual search for objects, these repetitions might alter the object-scene consistency effect by lowering of location uncertainty. Although we find evidence for a significant consistency effect, we find no clear support for impacts of scene priming or location priming on the size of the consistency effect. Additionally, we find evidence that the consistency effect is dependent on the eccentricity of the target objects. These results point to only small influences of priming to object-scene consistency effects but all-in-all the findings can be reconciled with a visual-search explanation of the consistency effect.

  15. Extra $Z^\\prime$s and $W^\\prime$s in Heterotic--String Derived Models

    CERN Document Server

    Faraggi, Alon E

    2015-01-01

    The ATLAS collaboration recently recorded possible excess in the di--boson production at the di--boson invariant mass at around 2 TeV. Such an excess may be produced if there exist additional $Z^\\prime$ and/or $W^\\prime$ at that scale. We survey the extra $Z^\\prime$s and $W^\\prime$s that may arise from semi--realistic heterotic string vacua in the free fermionic formulation in seven distinct cases including: $U(1)_{Z^\\prime}\\in SO(10)$; family universal $U(1)_{Z^\\prime}$ not in $SO(10)$; non--universal $U(1)_{Z^\\prime}$; hidden sector $U(1)$ symmetries and kinetic mixing; left--right symmetric models; Pati--Salam models; leptophobic and custodial symmetries. Each case has a distinct signature associated with the extra symmetry breaking scale. In one of the cases we explore the discovery potential at the LHC using resonant leptoproduction. Existence of extra vector boson with the reported properties will significantly constrain the space of allowed string vacua.

  16. NREL-Prime Next-Generation Drivetrain Dynamometer Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Jonathan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Erdman, Bill [Cinch, Inc., Moraga, CA (United States); Blodgett, Douglas [DNV KEMA Renewables, Burlington, VT (United States); Halse, Christopher [Romax Technology, Boulder, CO (United States)

    2016-08-01

    Advances in wind turbine drivetrain technologies are necessary to improve reliability and reduce the cost of energy for land-based and offshore wind turbines. The NREL-Prime Next-Generation Drivetrain team developed a geared, medium-speed drivetrain that is lighter, more reliable and more efficient than existing designs. One of the objectives of Phase II of the project was to complete the detailed design, fabrication, and dynamometer testing of a 750 kilowatt (kW) drivetrain that includes the key gearbox innovations designed by Romax Technology and power converter innovations designed by DNV Kema Renewables. The purpose of this document is to summarize these tests completed in NREL's National Wind Technology Center 2.5 megawatt (MW) dynamometer.

  17. The effect of retinal illuminance on visual motion priming.

    Science.gov (United States)

    Takeuchi, Tatsuto; Tuladhar, Anup; Yoshimoto, Sanae

    2011-05-25

    The perceived direction of a directionally ambiguous stimulus is influenced by the moving direction of a preceding priming stimulus. Previous studies have shown that a brief priming stimulus induces positive motion priming, in which a subsequent directionally ambiguous stimulus is perceived to move in the same direction as the primer, while a longer priming stimulus induces negative priming, in which the following ambiguous stimulus is perceived to move in the opposite direction of the primer. The purpose of this study was to elucidate the underlying mechanism of motion priming by examining how retinal illuminance and velocity of the primer influences the perception of priming. Subjects judged the perceived direction of 180-deg phase-shifted (thus directionally ambiguous) sine-wave gratings displayed immediately after the offset of a primer stimulus. We found that perception of motion priming was greatly modulated by the retinal illuminance and velocity of the primer. Under low retinal illuminance, positive priming nearly disappeared even when the effective luminance contrast was equated between different conditions. Positive priming was prominent when the velocity of the primer was low, while only negative priming was observed when the velocity was high. These results suggest that the positive motion priming is induced by a higher-order mechanism that tracks prominent features of the visual stimulus, while a directionally selective motion mechanism induces negative motion priming.

  18. Early and delayed prediction of axillary lymph node neoadjuvant response by {sup 18}F-FDG PET/CT in patients with locally advanced breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Vicente, Ana Maria; Soriano Castrejon, Angel; Jimenez Londono, German Andres [University General Hospital, Nuclear Medicine Department, Ciudad Real (Spain); Leon Martin, Alberto [University General Hospital, Investigation Unit, Ciudad Real (Spain); Relea Calatayud, Fernanda [University General Hospital, Pathology Department, Ciudad Real (Spain); Munoz Sanchez, Maria del Mar [Virgen de la Luz Hospital, Oncology Department, Cuenca (Spain); Cruz Mora, Miguel Angel [Virgen de la Salud Hospital, Oncology Department, Toledo (Spain); Espinosa Aunion, Ruth [La Mancha Centro Hospital, Oncology Department, Ciudad Real (Spain)

    2014-07-15

    To determine the utility of {sup 18}F-FDG (FDG) PET/CT performed in an early and delayed phase during neoadjuvant chemotherapy in the prediction of lymph node histopathological response in patients with locally advanced breast cancer. FDG PET/CT studies performed in 76 patients (mean age 53 years) at baseline (PET-1), after the second course of chemotherapy (PET-2) and after the last course of chemotherapy (PET-3) were prospectively analysed. Inclusion criteria were lymph node involvement detected by PET/CT and non-sentinel node biopsy before or after the baseline PET/CT scan. Following the recommendations of the 12th International Breast Conference (St. Gallen), the patients were divided into five subgroups in relation to biological prognostic factors by immunohistochemistry. For diagnosis visual and semiquantitative analyses was performed. Absence of detectable lymph node uptake on the PET-2 or PET-3 scan with respect to the PET-1 scan was considered metabolic complete response (mCR). Lymph nodes were histopathologically classified according the lymph node regression grade and in response groups as pathological complete response (pCR) or not pCR (type A/D or B/C of the Smith grading system, respectively). ROC analysis was performed to determine a cut-off value of Δ% SUV1-2 and SUV1-3 for prediction of nodal status after chemotherapy. An association between mCR and pCR was found (Cohen's kappa analysis), and associations between phenotypes and metabolic behaviour and the final histopathological status were also found. Lymph node pCR was seen in 34 patients. The sensitivity, specificity, and positive and negative predictive values of PET-2 and PET-3 in establishing the final status of the axilla after chemotherapy were 52 %, 45 %, 50 % and 47 %, and 33 %, 84 %, 67 % and 56 %, respectively. No significant relationship was observed between mCR on PET-2 and PET-3 and pCR (p = 0.31 and 0.99, respectively). Lymph node metabolism on PET-1 was not able to predict

  19. Location negative priming effects in children with developmental dyslexia: An event-related potential study.

    Science.gov (United States)

    Ma, Yujun; Wang, Enguo; Yuan, Tian; Zhao, Guo Xiang

    2016-08-01

    As the reading process is inseparable from working memory, inhibition, and other higher cognitive processes, the deep cognitive processing defects that are associated with dyslexia may be due to defective distraction inhibition systems. In this study, we used event-related potential technology to explore the source of negative priming effects in children with developmental dyslexia and in a group of healthy children for comparison. We found that the changes in the average response times in the negative priming and control conditions were consistent across the two groups, while the negative priming effects differed significantly between the groups. The magnitude of the negative priming effect was significantly different between the two groups, with the magnitude being significantly higher in the control group than it was in the developmental dyslexia group. These results indicate that there are deficits in distraction inhibition in children with developmental dyslexia. In terms of the time course of processing, inhibition deficits in the dyslexia group appeared during early-stage cognition selection and lasted through the response selection phase. Regarding the cerebral cortex locations, early-stage cognition selection was mainly located in the parietal region, while late-stage response selection was mainly located in the frontal and central regions. The results of our study may help further our understanding of the intrinsic causes of developmental dyslexia.

  20. KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors.

    Directory of Open Access Journals (Sweden)

    Ignacio Garrido-Laguna

    Full Text Available PURPOSE: To evaluate clinicopathologic and molecular features of patients with metastatic colorectal cancer (mCRC and their outcomes in early-phase trials using pathway-targeting agents. PATIENTS AND METHODS: We analyzed characteristics of 238 patients with mCRC referred to the phase 1 trials unit at MD Anderson Cancer Center. KRAS, PIK3CA and BRAF status were tested using PCR-based DNA sequencing. RESULTS: Fifty-one percent of patients harbored KRAS mutations; 15% had PIK3CA mutations. In the multivariate regression model for clinical characteristics KRAS mutations were associated with an increased incidence of lung and bone metastases and decreased incidence of adrenal metastases; PIK3CA mutations were marginally correlated with mucinous tumors (p = 0.05. In the univariate analysis, KRAS and PIK3CA mutations were strongly associated. Advanced Duke's stage (p<0.0001 and KRAS mutations (p = 0.01 were the only significant independent predictors of poor survival (Cox proportional hazards model. Patients with PIK3CA mutations had a trend toward shorter progression-free survival when treated with anti-EGFR therapies (p = 0.07. Eighteen of 78 assessable patients (23% treated with PI3K/Akt/mTOR axis inhibitors achieved stable disease [SD] ≥6 months or complete response/partial response (CR/PR, only one of whom were in the subgroup (N = 15 with PIK3CA mutations, perhaps because 10 of these 15 patients (67% had coexisting KRAS mutations. No SD ≥6 months/CR/PR was observed in the 10 patients treated with mitogen-activating protein kinase (MAPK pathway targeting drugs. CONCLUSIONS: KRAS and PIK3CA mutations frequently coexist in patients with colorectal cancer, and are associated with clinical characteristics and outcome. Overcoming resistance may require targeting both pathways.

  1. Evaluation of early response to concomitant chemoradiotherapy by interim {sup 18}F-FDG PET/CT imaging in patients with locally advanced oesophageal carcinomas

    Energy Technology Data Exchange (ETDEWEB)

    Cuenca, Xavier; Hennequin, Christophe; Rivera, Sofia; Baruch-Hennequin, Valerie [Saint Louis Hospital, AP-HP, Department of Radiation Oncology, Paris (France); Denis Diderot University (Paris 7), Paris (France); Hindie, Elif [Saint Louis Hospital, AP-HP, Nuclear Medicine Department, Paris (France); Denis Diderot University (Paris 7), Paris (France); University of Bordeaux, Department of Nuclear Medicine, Haut-Leveque Hospital, CHU Bordeaux (France); Vercellino, Laetitia [Saint Louis Hospital, AP-HP, Nuclear Medicine Department, Paris (France); Denis Diderot University (Paris 7), Paris (France); Gornet, Jean-Marc [Saint Louis Hospital, AP-HP, Gastroenterology Department, Paris (France); Denis Diderot University (Paris 7), Paris (France); Cattan, Pierre; Chirica, Mircea [Saint Louis Hospital, AP-HP, Surgery Department, Paris (France); Denis Diderot University (Paris 7), Paris (France); Quero, Laurent [Saint Louis Hospital, AP-HP, Department of Radiation Oncology, Paris (France); Denis Diderot University (Paris 7), Paris (France)

    2013-04-15

    The best way to assess the response to chemoradiotherapy of locally advanced oesophageal carcinomas is not known. We used {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to evaluate the metabolic response during chemoradiotherapy and tried to correlate this response to survival. Patients with biopsy-proven oesophageal carcinoma underwent FDG PET/CT with evaluation of the standardized uptake value (SUV) before any treatment (SUV1) and during chemoradiotherapy after two cycles of 5-fluorouracil (FU)/cisplatin and 20 Gy (SUV2). Metabolic response was defined as 1-(SUV2/SUV1). Surgery was discussed after 40 Gy and three cycles of chemotherapy. Results of interim PET were not considered for the therapeutic decision. Among 72 patients who underwent a first FDG PET/CT before any treatment, 59 (82 %) could receive the second FDG PET/CT examination. Median survival was 22.2 months with 1-year and 2-year survivals of 70 and 46 %, respectively. Nineteen patients (32 %) underwent surgery. Mean SUV1 and SUV2 were 12.3 {+-} 6.2 and 6 {+-} 4.1, respectively (p < 0.001). Using a cut-off for metabolic response of 50 %, sensitivity and specificity for survival were 0.7 and 0.58. The 2-year overall survival of good responders was 62 % as compared to 27 % for poor metabolic responders. A multivariate analysis was performed, including T and N stages, surgery, histology and metabolic response: only metabolic response was significantly (p = 0.009) associated with 2-year survival. Early evaluation of metabolic response had a great prognostic value and could help identify good responders to chemoradiotherapy. (orig.)

  2. Distribution law for twin primes amongst naturals

    CERN Document Server

    Benyaminov, Boris B

    2011-01-01

    A hypothesis is put forward regarding the function $\\pi_2(x)$ which describes the distribution of twin primes in the set of natural numbers. The function $\\pi_2(x)$ is tested by evaluation and an empirical $\\pi_2^{\\ast}(x)$ is arrived at, which is shown to be highly accurate. Several other questions are also addressed.

  3. Sums of Five Almost Equal Prime Squares

    Institute of Scientific and Technical Information of China (English)

    Claus BAUER

    2005-01-01

    Let Pi, 1 ≤ i ≤ 5, be prime numbers. It is proved that every integer N that satisfies N ≡ 5 (mod 24) can be written as N = p1 2 + p2 2 + p2 3 + P4 2 + p5 2, where |√N5-pi| ≤ N1/2- s19/850+∈.

  4. Bidirectional Priming Processes in the Simon Task

    Science.gov (United States)

    Metzker, Manja; Dreisbach, Gesine

    2009-01-01

    The Simon effect is mostly explained in terms of dual-route models, which imply unidirectional activation processes from stimulus features to response features. However, there is also evidence that these preactivated response features themselves prime corresponding stimulus features. From this perspective, the Simon effect should only occur…

  5. Thematic Mathematics: The Combinatorics of Prime Factorizations

    Science.gov (United States)

    Griffiths, Martin

    2010-01-01

    In this article, we use a particular example to illustrate a thematic approach to the teaching and learning of mathematics. Our theme, suitable for undergraduates and able sixth-form students, is the enumeration of mathematical objects associated with the prime factorizations of integers. It is shown in detail how this gives rise to some beautiful…

  6. Kunlun Melts into Prime Time of CCTV

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    @@ On November 18, China Central Television (CCTV), the national broadcaster with more than 1 billion viewers, auctioned off its prime-time advertising time for next year at 32.40million yuan. The winner of the bid is lubricants branded as Kunlun from PetroChina Lubricants Company.

  7. Colorimetry and prime colours--a theorem.

    Science.gov (United States)

    Hornaes, Hans Petter; Wold, Jan Henrik; Farup, Ivar

    2005-08-01

    Human colour vision is the result of a complex process involving topics ranging from physics of light to perception. Whereas the diversity of light entering the eye in principle span an infinite-dimensional vector space in terms of the spectral power distributions, the space of human colour perceptions is three dimensional. One important consequence of this is that a variety of colours can be visually matched by a mixture of only three adequately chosen reference lights. It has been observed that there exists one particular set of monochromatic reference lights that, according to a certain definition, is optimal for producing colour matches. These reference lights are commonly denoted prime colours. In the present paper, we intend to rigorously show that the existence of prime colours is not particular to the human visual system as sometimes stated, but rather an algebraic consequence of the manner in which a kind of colorimetric functions called colour-matching functions are defined and transformed. The solution is based on maximisation of a determinant determining the gamut size of the colour space spanned by the prime colours. Cramer's rule for solving a set of linear equations is an essential part of the proof. By means of examples, it is shown that mathematically the optimal set of reference lights is not unique in general, and that the existence of a maximum determinant is not a necessary condition for the existence of prime colours.

  8. 30 CFR 716.7 - Prime farmland.

    Science.gov (United States)

    2010-07-01

    ... or planted. (6) Apply nutrients and soil amendments as needed to establish quick vegetative growth. ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Prime farmland. 716.7 Section 716.7 Mineral... those lands which are defined by the Secretary of Agriculture in 7 CFR 657 and which have...

  9. What drives priming effects in the affect misattribution procedure?

    Science.gov (United States)

    Gawronski, Bertram; Ye, Yang

    2014-01-01

    The affect misattribution procedure (AMP) is one of the most promising implicit measures to date, showing high reliability and large effect sizes. The current research tested three potential sources of priming effects in the AMP: affective feelings, semantic concepts, and prepotent motor responses. Ruling out prepotent motor responses as a driving force, priming effects on evaluative and semantic target responses occurred regardless of whether the key assignment in the task was fixed or random. Moreover, priming effects emerged for affect-eliciting primes in the absence of semantic knowledge about the primes. Finally, priming effects were independent of the order in which primes and targets were presented, suggesting that AMP effects are driven by misattribution rather than biased perceptions of the targets. Taken together, these results support accounts that attribute priming effects in the AMP to a general misattribution mechanism that can operate on either affective feelings or semantic concepts.

  10. The PRIME model: a management solution in academic medicine ...

    African Journals Online (AJOL)

    The PRIME model: a management solution in academic medicine. ... School of Medicine, measured against the background of good management practices. ... the principles of the PRIME model in other Medical Schools in South Africa in order ...

  11. Comparison of affective and semantic priming in different SOA.

    Science.gov (United States)

    Jiang, Zhongqing; Qu, Yuhong; Xiao, Yanli; Wu, Qi; Xia, Likun; Li, Wenhui; Liu, Ying

    2016-11-01

    Researchers have been at odds on whether affective or semantic priming is faster or stronger. The present study selects a series of facial expression photos and words, which have definite emotional meaning or gender meaning, to set up experiment including both affective and semantic priming. The intensity of emotion and gender information in the prime as well as the strength of emotional or semantic (in gender) relationship between the prime and the target is matched. Three groups of participants are employed separately in our experiment varied with stimulus onset asynchrony (SOA) as 50, 250 or 500 ms. The results show that the difference between two types of priming effect is revealed when the SOA is at 50 ms, in which the affective priming effect is presented when the prime has negative emotion. It indicates that SOA can affect the comparison between the affective and semantic priming, and the former takes the priority in the automatic processing level.

  12. DNA polymerase preference determines PCR priming efficiency

    Science.gov (United States)

    2014-01-01

    Background Polymerase chain reaction (PCR) is one of the most important developments in modern biotechnology. However, PCR is known to introduce biases, especially during multiplex reactions. Recent studies have implicated the DNA polymerase as the primary source of bias, particularly initiation of polymerization on the template strand. In our study, amplification from a synthetic library containing a 12 nucleotide random portion was used to provide an in-depth characterization of DNA polymerase priming bias. The synthetic library was amplified with three commercially available DNA polymerases using an anchored primer with a random 3’ hexamer end. After normalization, the next generation sequencing (NGS) results of the amplified libraries were directly compared to the unamplified synthetic library. Results Here, high throughput sequencing was used to systematically demonstrate and characterize DNA polymerase priming bias. We demonstrate that certain sequence motifs are preferred over others as primers where the six nucleotide sequences at the 3’ end of the primer, as well as the sequences four base pairs downstream of the priming site, may influence priming efficiencies. DNA polymerases in the same family from two different commercial vendors prefer similar motifs, while another commercially available enzyme from a different DNA polymerase family prefers different motifs. Furthermore, the preferred priming motifs are GC-rich. The DNA polymerase preference for certain sequence motifs was verified by amplification from single-primer templates. We incorporated the observed DNA polymerase preference into a primer-design program that guides the placement of the primer to an optimal location on the template. Conclusions DNA polymerase priming bias was characterized using a synthetic library amplification system and NGS. The characterization of DNA polymerase priming bias was then utilized to guide the primer-design process and demonstrate varying amplification

  13. A comparative approach between heterologous prime-boost vaccination strategy and DNA vaccinations for rabies.

    Science.gov (United States)

    Borhani, Kiandokht; Ajorloo, Mehdi; Bamdad, Taravat; Mozhgani, Sayed Hamid Reza; Ghaderi, Mostafa; Gholami, Ali Reza

    2015-04-01

    Rabies is a widespread neurological zoonotic disease causing significant mortality rates, especially in developing countries. Although a vaccine for rabies is available, its production and scheduling are costly in such countries. Advances in recombinant DNA technology have made it a good candidate for an affordable vaccine. Among the proteins of rabies virus, the Glycoprotein (RVG) has been the major target for new vaccine development which plays the principal role in providing complete protection against RV challenge. The aim of this study is to produce recombinant RVG which could be a DNA vaccine candidate and to evaluate the efficiency of this construct in a prime-boost vaccination regimen, compared to commercial vaccine. Cloning to pcDNA3.1(+) and expression of rabies virus glycoprotein gene in BSR cell  line were performed followed by SDS-PAGE and Western blot analysis of the expressed glycoprotein. The resulting genetic construct was used as a DNA vaccine by injecting 80 µg of the plasmid to MNRI mice twice. Prime-Boost vaccination strategy was performed using 80 µg plasmid construct as prime dose and the second dose of an inactivated rabies virus vaccine. Production of rabies virus neutralizing antibody (RVNA) titers of the serum samples were determined by RFFIT. In comparisons between heterologous prime-boost vaccination strategy and DNA vaccinations, the potency of group D that received Prime-Boost vaccine with the second dose of pcDNA3.1(+)-Gp was enhanced significantly compared to the group C which had received pcDNA3.1(+)-Gp as first injection. In this study, RVGP expressing construct was used in a comparative approach between Prime-Boost vaccination strategy and DNA vaccination and compared with the standard method of rabies vaccination. It was concluded that this strategy could lead to induction of acceptable humoral immunity.

  14. Rhizosphere priming effects in two contrasting soils

    Science.gov (United States)

    Lloyd, Davidson; Kirk, Guy; Ritz, Karl

    2015-04-01

    Inputs of fresh plant-derived carbon may stimulate the turnover of existing soil organic matter by so-called priming effects. Priming may occur directly, as a result of nutrient 'mining' by existing microbial communities, or indirectly via population adjustments. However the mechanisms are poorly understood. We planted C4 Kikuyu grass (Pennisetum clandestinum) in pots with two contrasting C3 soils (clayey, fertile TB and sandy, acid SH), and followed the soil CO2 efflux and its δ13C. The extent of C deposition in the rhizosphere was altered by intermittently clipping the grass in half the pots; there were also unplanted controls. At intervals, pots were destructively sampled for root and shoot biomass. Total soil CO2 efflux was measured using a gas-tight PVC chamber fitted over bare soil, and connected to an infra-red gas analyser; the δ13C of efflux was measured in air sub-samples withdrawn by syringe. The extent of priming was inferred from the δ13C of efflux and the δ13C of the plant and soil end-members. In unclipped treatments, in both soils, increased total soil respiration and rhizosphere priming effects (RPE) were apparent compared to the unplanted controls. The TB soil had greater RPE overall. The total respiration in clipped TB soil was significantly greater than in the unplanted controls, but in the clipped SH soil it was not significantly different from the controls. Clipping affected plant C partitioning with greater allocation to shoot regrowth from about 4 weeks after planting. Total plant biomass decreased in the order TB unclipped > SH unclipped >TB clipped > SH clipped. The results are consistent with priming driven by microbial activation stimulated by rhizodeposits and by nitrogen demand from the growing plants under N limited conditions. Our data suggest that photosynthesis drives RPE and soil differences may alter the rate and intensity of RPE but not the direction.

  15. On algebraic structure of the set of prime numbers

    OpenAIRE

    Zahedi, Ramin

    2012-01-01

    The set of prime numbers has been analyzed, based on their algebraic and arithmetical structure. Here by obtaining a sort of linear formula for the set of prime numbers, they are redefined and identified; under a systematic procedure it has been shown that the set of prime numbers is combinations (unions and intersections) of some subsets of natural numbers, with more primary structures. In fact generally, the logical essence of obtained formula for prime numbers is similar to formula 2n - 1 ...

  16. Neuroscience and education: prime time to build the bridge.

    Science.gov (United States)

    Sigman, Mariano; Peña, Marcela; Goldin, Andrea P; Ribeiro, Sidarta

    2014-04-01

    As neuroscience gains social traction and entices media attention, the notion that education has much to benefit from brain research becomes increasingly popular. However, it has been argued that the fundamental bridge toward education is cognitive psychology, not neuroscience. We discuss four specific cases in which neuroscience synergizes with other disciplines to serve education, ranging from very general physiological aspects of human learning such as nutrition, exercise and sleep, to brain architectures that shape the way we acquire language and reading, and neuroscience tools that increasingly allow the early detection of cognitive deficits, especially in preverbal infants. Neuroscience methods, tools and theoretical frameworks have broadened our understanding of the mind in a way that is highly relevant to educational practice. Although the bridge's cement is still fresh, we argue why it is prime time to march over it.

  17. Retro-priming, priming and double testing : psi and replication in a test-retest design

    OpenAIRE

    Thomas eRabeyron

    2014-01-01

    Numerous experiments have been conducted in recent years on anomalous retroactive influences on cognition and affect (Bem, 2010), yet more data are needed to understand these processes precisely. For this purpose, we carried out an initial retro-priming study in which the response times of 162 participants were measured (Rabeyron & Watt, 2010). In the current paper, we present the results of a second study in which we selected those participants who demonstrated the strongest retro-priming ef...

  18. Retro-priming, priming, and double testing: psi and replication in a test–retest design

    OpenAIRE

    Rabeyron, Thomas

    2014-01-01

    Numerous experiments have been conducted in recent years on anomalous retroactive influences on cognition and affect (Bem, 2010), yet more data are needed to understand these processes precisely. For this purpose, we carried out an initial retro-priming study in which the response times of 162 participants were measured (Rabeyron and Watt, 2010). In the current paper, we present the results of a second study in which we selected those participants who demonstrated the strongest retro-priming ...

  19. Shifting Evaluation Windows: Predictable Forward Primes with Long SOAs Eliminate the Impact of Backward Primes

    OpenAIRE

    Fockenberg, Daniel A.; Koole, Sander L; Daniël Lakens; Semin, Gün R.

    2013-01-01

    Shifting Evaluation Windows: Predictable Forward Primes with Long SOAs Eliminate the Impact of Backward Primes Daniel A. Fockenberg1*, Sander L. Koole2, Danie¨ l Lakens3, Gu¨ n R. Semin4,5 1 Institut fu¨ r Psychologie, Albert-Ludwigs-Universita¨t Freiburg, Freiburg, Germany, 2 Department of Clinical Psychology, VU University Amsterdam, Amsterdam, The Netherlands, 3 Eindhoven University of Technology, Eindhoven, The Netherlands, 4 Royal Netherlands Academy for Arts and Sciences,...

  20. PrimeIndel: four-prime-number genetic code for indel decryption and sequence read alignment.

    Science.gov (United States)

    Lam, Ching-Wan

    2014-09-25

    To decrypt a doubly heterozygous sequence (DHS) in order to define the indel mutation for mutation reporting, an algorithm recursively searching the overlapped nucleotide using an offset of nucleotide positions can decrypt the indel without using a reference sequence. However, as genetic code is letter-based, special computer programs are required to run the decryption algorithm. The previous text-based algorithm was converted to a number-based algorithm by expressing DNA sequence from a 4-letter genetic code to a 4-prime-number genetic code, i.e., converting A, C, G, T to 2, 3, 5, and 7. This algorithm based on prime-number genetic code is called PrimeIndel and is executable by spreadsheet. Using prime number coded DNA sequence, the overlapped nucleotide between any 2 positions of the DHS is represented by the greatest common divisor (GCD) of the multiplication product of 2 prime numbers. This algorithm can also be used for aligning multiple overlapping sequence reads by in-silico DHS formation. The indel size of the in-silico formed DHS indicates the positions in the paired sequences for correct alignment. DHSs were successfully decrypted by the prime number-based algorithm and sequence reads were aligned correctly. DNA sequence expressed in prime numbers can be used for the decryption of DHS and the alignment of sequence reads using a well-known mathematical function GCD of a spreadsheet program. PrimeIndel is a useful tool for mutation reporting in clinical laboratories. The software is downloadable from http://www.patho.hku.hk/staff/list/cwlam.htm. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Then We Characterize Primes and Composite Numbers Via Divisibility

    Directory of Open Access Journals (Sweden)

    Ikorong Gilbert

    2013-12-01

    Full Text Available In this paper, we show a Theorem which helps us to characterize prime numbers and composite numbers via divisibility; and we use the characterizations of primes and composite numbers to characterize twin primes, Mersenne primes, even perfect numbers, Sophie Germain primes, Fermat primes, Fermat composite numbers and Mersenne composite numbers (we recall that a logic (non recursive proof of problems posed by twin primes, Mersenne primes, perfect numbers, Sophie Germain primes, Fermat primes, Fermat composite numbers and Mersenne composite numbers, is given in [12]. [[ Prime numbers are well kwown ( see [15] or [19] and we recall that a composite number is a non prime number. We recall (see [1] or [2] or [3] or [6] or [9] or [10] or [12] or [13] or [14] or [17] that a {\\it{Fermat prime }} is a prime of the form F_{n}=2^{2^{n}}+1, where n is an integer \\geq 0; and a {\\it{Fermat composite}}  is a non prime number of the form F_{n}=2^{2^{n}}+1, where n is an integer \\geq 1; it is known that for every j\\in \\lbrace 0, 1,2,3,4\\rbrace, F_{j} is a Fermat prime,  and it is also known that F_{5} and F_{6} are Fermat composite. We recall (see [11] that a prime h is called a {\\it{Sophie Germain prime}}, if both h and 2h+1 are prime; the first few Sophie Germain primes are 2, 3,5,11,23,29,41, ...; it is easy to check that 233 is a Sophie  Germain prime. A {\\it{Mersenne prime }} (see [6] or [10] or [11] or [16] or [19] or [20] or [21] is a prime of the form M_{m}=2^{m}-1, where m is prime; for example M_{13} and M_{19} are Mersenne prime. A Mersenne composite ( see [7] or [9]  is a non prime number of the form M_{m}=2^{m}-1, where m is prime; it is known that M_{11} and M_{67} are Mersenne composite. We also recall (see [4] or [5] or [7] or [8] or [10] or [11] or [18] or [19] or [20] or [22] that an integer t is a twin prime, if t is a prime \\geq 3 and if t-2 or t+2 is also a prime \\geq 3; for example, it is easy to check that (881,883 is a

  2. It takes time to prime: semantic priming in the ocular lexical decision task.

    Science.gov (United States)

    Hoedemaker, Renske S; Gordon, Peter C

    2014-12-01

    Two eye-tracking experiments were conducted in which the manual response mode typically used in lexical decision tasks (LDTs) was replaced with an eye-movement response through a sequence of 3 words. This ocular LDT combines the explicit control of task goals found in LDTs with the highly practiced ocular response used in reading text. In Experiment 1, forward saccades indicated an affirmative lexical decision (LD) on each word in the triplet. In Experiment 2, LD responses were delayed until all 3 letter strings had been read. The goal of the study was to evaluate the contribution of task goals and response mode to semantic priming. Semantic priming is very robust in tasks that involve recognition of words in isolation, such as LDT, but limited during text reading, as measured using eye movements. Gaze durations in both experiments showed robust semantic priming even though ocular response times were much shorter than manual LDs for the same words in the English Lexicon Project. Ex-Gaussian distribution fits revealed that the priming effect was concentrated in estimates of tau (τ), meaning that priming was most pronounced in the slow tail of the distribution. This pattern shows differential use of the prime information, which may be more heavily recruited in cases in which the LD is difficult, as indicated by longer response times. Compared with the manual LD responses, ocular LDs provide a more sensitive measure of this task-related influence on word recognition as measured by the LDT.

  3. Masked Translation Priming with Semantic Categorization: Testing the Sense Model

    Science.gov (United States)

    Wang, Xin; Forster, Kenneth I.

    2010-01-01

    Four experiments are reported which were designed to test hypotheses concerning the asymmetry of masked translation priming. Experiment 1 confirmed the presence of L2-L1 priming with a semantic categorization task and demonstrated that this effect was restricted to exemplars. Experiment 2 showed that the translation priming effect was not due to…

  4. Give and Take: Syntactic Priming during Spoken Language Comprehension

    Science.gov (United States)

    Thothathiri, Malathi; Snedeker, Jesse

    2008-01-01

    Syntactic priming during language production is pervasive and well-studied. Hearing, reading, speaking or writing a sentence with a given structure increases the probability of subsequently producing the same structure, regardless of whether the prime and target share lexical content. In contrast, syntactic priming during comprehension has proven…

  5. The Nature of Affective Priming in Music and Speech

    NARCIS (Netherlands)

    Goerlich, K.S.; Witteman, J.; Schiller, N.O.; Van Heuven, V.J.; Aleman, A.; Martens, S.

    2012-01-01

    The phenomenon of affective priming has caught scientific interest for over 30 years, yet the nature of the affective priming effect remains elusive. This study investigated the underlying mechanism of cross-modal affective priming and the influence of affective incongruence in music and speech on n

  6. Do Stimulus-Action Associations Contribute to Repetition Priming?

    Science.gov (United States)

    Dennis, Ian; Perfect, Timothy J.

    2013-01-01

    Despite evidence that response learning makes a major contribution to repetition priming, the involvement of response representations at the level of motor actions remains uncertain. Levels of response representation were investigated in 4 experiments that used different tasks at priming and test. Priming for stimuli that required congruent…

  7. Prospective and Retrospective Processing in Associative Mediated Priming

    Science.gov (United States)

    Jones, Lara L.

    2012-01-01

    Mediated priming refers to the faster word recognition of a target (e.g., milk) following presentation of a prime (e.g., pasture) that is related indirectly via a connecting "mediator" (e.g., cow). Association strength may be an important factor in whether mediated priming occurs prospectively (with target activation prior to its presentation) or…

  8. Masked Translation Priming with Semantic Categorization: Testing the Sense Model

    Science.gov (United States)

    Wang, Xin; Forster, Kenneth I.

    2010-01-01

    Four experiments are reported which were designed to test hypotheses concerning the asymmetry of masked translation priming. Experiment 1 confirmed the presence of L2-L1 priming with a semantic categorization task and demonstrated that this effect was restricted to exemplars. Experiment 2 showed that the translation priming effect was not due to…

  9. Structural Priming and Frequency Effects Interact in Chinese Sentence Comprehension.

    Science.gov (United States)

    Wei, Hang; Dong, Yanping; Boland, Julie E; Yuan, Fang

    2016-01-01

    Previous research in several European languages has shown that the language processing system is sensitive to both structural frequency and structural priming effects. However, it is currently not clear whether these two types of effects interact during online sentence comprehension, especially for languages that do not have morphological markings. To explore this issue, the present study investigated the possible interplay between structural priming and frequency effects for sentences containing the Chinese ambiguous construction V NP1 de NP2 in a self-paced reading experiment. The sentences were disambiguated to either the more frequent/preferred NP structure or the less frequent VP structure. Each target sentence was preceded by a prime sentence of three possible types: NP primes, VP primes, and neutral primes. When the ambiguous construction V NP1 de NP2 was disambiguated to the dispreferred VP structure, participants experienced more processing difficulty following an NP prime relative to following a VP prime or a neutral baseline. When the ambiguity was resolved to the preferred NP structure, prime type had no effect. These results suggest that structural priming in comprehension is modulated by the baseline frequency of alternative structures, with the less frequent structure being more subject to structural priming effects. These results are discussed in the context of the error-based, implicit learning account of structural priming.

  10. Space-Valence Priming with Subliminal and Supraliminal Words

    Directory of Open Access Journals (Sweden)

    Ulrich eAnsorge

    2013-02-01

    Full Text Available To date it is unclear whether (1 awareness-independent non-evaluative semantic processes influence affective semantics and whether (2 awareness-independent affective semantics influence non-evaluative semantic processing. In the current study, we investigated these questions with the help of subliminal (masked primes and visible targets in a space-valence across-category congruence effect. In line with (1, we found that subliminal space prime words influenced valence classification of supraliminal target words (Experiment 1: Classifications were faster with a congruent prime (e.g., the prime ‘up’ before the target ‘happy’ than with an incongruent prime (e.g., the prime ‘up’ before the target ‘sad’. In contrast to (2, no influence of subliminal valence primes on the classification of supraliminal space targets into up- and down-words was found (Experiment 2. Control conditions showed that standard masked response-priming effects were found with both subliminal prime types, and that an across-category congruence effect was also found with supraliminal valence primes and spatial target words. The final Experiment 3 confirmed that the across-category congruence effect indeed reflected priming of target categorization of a relevant meaning category. Together, the data jointly confirmed prediction (1 that awareness-independent non-evaluative semantic priming influences valence judgments.

  11. Does "Darkness" Lead to "Happiness"? Masked Suffix Priming Effects

    Science.gov (United States)

    Dunabeitia, Jon Andoni; Perea, Manuel; Carreiras, Manuel

    2008-01-01

    Masked affix priming effects have usually been obtained for words sharing the initial affix (e.g., "reaction"-"REFORM"). However, prior evidence on masked suffix priming effects (e.g., "baker"-"WALKER") is inconclusive. In the present series of masked priming lexical decision experiments, a target word was…

  12. Electrophysiological and Behavioral Evidence of Syntactic Priming in Sentence Comprehension

    Science.gov (United States)

    Tooley, Kristen M.; Traxler, Matthew J.; Swaab, Tamara Y.

    2009-01-01

    Event-related potentials and eye tracking were used to investigate the nature of priming effects in sentence comprehension. Participants read 2 sentences (a prime sentence and a target sentence), both of which had a difficult and ambiguous sentence structure. The prime and target sentences contained either the same verb or verbs that were very…

  13. Differential Effects of Phonological Priming on Chinese Character Recognition.

    Science.gov (United States)

    Weekes, B. S.; Chen, M. J.; Lin, Y-B.

    1998-01-01

    Finds phonological priming effects on compound targets (characters containing separate radical components); no evidence of phonological priming on integrated targets (those not containing separate radicals); semantic priming effects on both compound and integrated target recognition, suggesting that phonological and semantic activation are…

  14. Novel Word Lexicalization and the Prime Lexicality Effect

    Science.gov (United States)

    Qiao, Xiaomei; Forster, Kenneth I.

    2013-01-01

    This study investigates how newly learned words are integrated into the first-language lexicon using masked priming. Two lexical decision experiments are reported, with the aim of establishing whether newly learned words behave like real words in a masked form priming experiment. If they do, they should show a prime lexicality effect (PLE), in…

  15. The Nature of Affective Priming in Music and Speech

    NARCIS (Netherlands)

    Goerlich, K.S.; Witteman, J.; Schiller, N.O.; Van Heuven, V.J.; Aleman, A.; Martens, S.

    The phenomenon of affective priming has caught scientific interest for over 30 years, yet the nature of the affective priming effect remains elusive. This study investigated the underlying mechanism of cross-modal affective priming and the influence of affective incongruence in music and speech on

  16. Do Stimulus-Action Associations Contribute to Repetition Priming?

    Science.gov (United States)

    Dennis, Ian; Perfect, Timothy J.

    2013-01-01

    Despite evidence that response learning makes a major contribution to repetition priming, the involvement of response representations at the level of motor actions remains uncertain. Levels of response representation were investigated in 4 experiments that used different tasks at priming and test. Priming for stimuli that required congruent…

  17. Prospective and Retrospective Processing in Associative Mediated Priming

    Science.gov (United States)

    Jones, Lara L.

    2012-01-01

    Mediated priming refers to the faster word recognition of a target (e.g., milk) following presentation of a prime (e.g., pasture) that is related indirectly via a connecting "mediator" (e.g., cow). Association strength may be an important factor in whether mediated priming occurs prospectively (with target activation prior to its presentation) or…

  18. Integrative Priming Occurs Rapidly and Uncontrollably during Lexical Processing

    Science.gov (United States)

    Estes, Zachary; Jones, Lara L.

    2009-01-01

    Lexical priming, whereby a prime word facilitates recognition of a related target word (e.g., "nurse" [right arrrow] "doctor"), is typically attributed to association strength, semantic similarity, or compound familiarity. Here, the authors demonstrate a novel type of lexical priming that occurs among unassociated, dissimilar,…

  19. Priming treatments for improvement of germination and emergence of cotton seeds at low temperature

    Directory of Open Access Journals (Sweden)

    Çokkizgin Hatice

    2015-12-01

    Full Text Available Early sowing in cotton is important for obtaining a high and qualiy yield. Since cotton prefers high temperatures to have a good stand establisment, this work is important to determine better performing genotypes or to promote germination and emergence at low temperatures (<20°C. This research aimed to increase seed germination rate and seed vigour under cold stress conditions. Two cotton genotypes belonging to G. hirsutum L. species (Aydin-110 and Paymaster-2379 were primed with PEG-6000 (200, 300, 400 g/L, KNO3 (2, 3, 4%, KH2PO4 (0.3, 0.4, 0.5 M, NaCl (2, 3, 4% or Mannitol (2, 4, 6% to determine the best priming medium and its best amount. After priming, seeds were germinated in germination cabin at cold (18°C and warm (30°C temperatures and some characteristics (germination rates, radicle length, hypocotyl length and seedling length were analyzed. Priming with KNO3 (4% or 2% was found to result in the highest germination rates in both cotton genotypes. The seeds of the genotypes were also primed with 5-aminolevulinic acid (ALA (1, 10, 25 mg/L, gibberellic acid (GA3 (100, 250, 500 μM, methyl jasmonate (MeJA (1, 3, 5 μM, acetylsalicylic acid (ASA (1, 10, 100 μM or kinetin (1, 5, 10 mg/L added to KNO3 (4% medium to choose the most effective plant growth regulator (PGR application and its dose. PGRs were observed to have reverse effects on germination rate. Finally, emergence test was conducted with KNO3 (4% and KNO3 (2% using metabolic chill test, and some traits (radicle length, radicle weight, hypocotyl length, hypocotyl weight, seedling length, seedling fresh weight and seedling dry weight were examined. Our results suggested that priming with KNO3 (2% might be an effecient way to have vigourous cotton plants under the cold stress.

  20. In Vitro Assays for RNA Binding and Protein Priming of Hepatitis B Virus Polymerase.

    Science.gov (United States)

    Clark, Daniel N; Jones, Scott A; Hu, Jianming

    2017-01-01

    The hepatitis B virus (HBV) polymerase synthesizes the viral DNA genome from the pre-genomic RNA (pgRNA) template through reverse transcription. Initiation of viral DNA synthesis is accomplished via a novel protein priming mechanism, so named because the polymerase itself acts as a primer, whereby the initiating nucleotide becomes covalently linked to a tyrosine residue on the viral polymerase. Protein priming, in turn, depends on specific recognition of the packaging signal on pgRNA called epsilon. These early events in viral DNA synthesis can now be dissected in vitro as described here.The polymerase is expressed in mammalian cells and purified by immunoprecipitation. The purified protein is associated with host cell factors, is enzymatically active, and its priming activity is epsilon dependent. A minimal epsilon RNA construct from pgRNA is co-expressed with the polymerase in cells. This RNA binds to and co-immunoprecipitates with the polymerase. Modifications can be made to either the epsilon RNA or the polymerase protein by manipulating the expression plasmids. Also, the priming reaction itself can be modified to assay for the initiation or subsequent DNA synthesis during protein priming, the susceptibility of the polymerase to chemical inhibitors, and the precise identification of the DNA products upon their release from the polymerase. The identity of associated host factors can also be evaluated. This protocol closely mirrors our current understanding of the RNA binding and protein priming steps of the HBV replication cycle, and it is amenable to modification. It should therefore facilitate both basic research and drug discovery.

  1. Recombinant BCG prime and PPE protein boost provides potent protection against acute Mycobacterium tuberculosis infection in mice.

    Science.gov (United States)

    Yang, Enzhuo; Gu, Jin; Wang, Feifei; Wang, Honghai; Shen, Hongbo; Chen, Zheng W

    2016-04-01

    Since BCG, the only vaccine widely used against tuberculosis (TB) in the world, provides varied protective efficacy and may not be effective for inducing long-term cellular immunity, it is in an urgent need to develop more effective vaccines and more potent immune strategies against TB. Prime-boost is proven to be a good strategy by inducing long-term protection. In this study, we tested the protective effect against Mycobacterium tuberculosis (Mtb) challenge of prime-boost strategy by recombinant BCG (rBCG) expressing PPE protein Rv3425 fused with Ag85B and Rv3425. Results showed that the prime-boost strategy could significantly increase the protective efficiency against Mtb infection, characterized by reduction of bacterial load in lung and spleen, attenuation of tuberculosis lesions in lung tissues. Importantly, we found that Rv3425 boost, superior to Ag85B boost, provided better protection against Mtb infection. Further research proved that rBCG prime-Rv3425 boost could obviously increase the expansion of lymphocytes, significantly induce IL-2 production by lymphocytes upon PPD stimulation, and inhibit IL-6 production at an early stage. It implied that rBCG prime-Rv3425 boost opted to induce Th1 immune response and provided a long-term protection against TB. These results implicated that rBCG prime-Rv3425 boost is a potent and promising strategy to prevent acute Mtb infection.

  2. Avanços na abordagem do carcinoma precoce de esôfago Advances in the management of early esophageal carcinoma

    Directory of Open Access Journals (Sweden)

    Vitor Arantes

    2012-12-01

    Full Text Available Nos países ocidentais, o carcinoma de células escamosas de esôfago (CCE geralmente é detectado em estágio avançado, quando as possibilidades de cura são remotas e o prognóstico reservado. Entretanto, nos anos recentes, ocorreu uma série de avanços na abordagem do CCE de esôfago, tais como a identificação dos grupos de risco para o surgimento desta neoplasia; o uso da endoscopia de alta resolução e cromoendoscopia com lugol favorecendo o diagnóstico do CCE em estágios iniciais; e o desenvolvimento de técnicas endoscópicas de ressecção tumoral endoluminal em monobloco denominada dissecção endoscópica de submucosa. Este progresso tem possibilitado a aplicação do tratamento endoscópico minimamente invasivo com potencial curativo em pacientes selecionados com CCE superficial de esôfago. O presente artigo de revisão, elaborado por um grupo multicêntrico internacional, tem como objetivo primário contribuir para o entendimento dos principais avanços recentes ocorridos no manejo do CCE precoce de esôfago. Como objetivo secundário, pretende propiciar uma revisão detalhada e minuciosa da estratégia técnica de DES desenvolvida pelos experts japoneses, de forma a colaborar para a difusão deste conceito e a incorporação destas tecnologias na Medicina Brasileira e Latino-americana.Esophageal squamous cell cancer (ESCC has a dismal prognosis mainly because its recognition in Western countries usually occurs in late stages, when the possibilities of cure are minimal. However, in recent years, several advances have been observed in the management of ESSC, such as the identification of high-risk patients, the use of high-resolution endoscopy and lugol chromoscopy favoring the diagnosis of early stage ESCC, and the development of endoluminal techniques of en-block tumor resection, namely endoscopic submucosal dissection (ESD. These factors have enabled the application of endoscopic minimally invasive curative interventions in

  3. Heterologous Prime-Boost HIV-1 Vaccination Regimens in Pre-Clinical and Clinical Trials

    Directory of Open Access Journals (Sweden)

    Julia L. Hurwitz

    2010-02-01

    Full Text Available Currently, there are more than 30 million people infected with HIV-1 and thousands more are infected each day. Vaccination is the single most effective mechanism for prevention of viral disease, and after more than 25 years of research, one vaccine has shown somewhat encouraging results in an advanced clinical efficacy trial. A modified intent-to-treat analysis of trial results showed that infection was approximately 30% lower in the vaccine group compared to the placebo group. The vaccine was administered using a heterologous prime-boost regimen in which both target antigens and delivery vehicles were changed during the course of inoculations. Here we examine the complexity of heterologous prime-boost immunizations. We show that the use of different delivery vehicles in prime and boost inoculations can help to avert the inhibitory effects caused by vector-specific immune responses. We also show that the introduction of new antigens into boost inoculations can be advantageous, demonstrating that the effect of ‘original antigenic sin’ is not absolute. Pre-clinical and clinical studies are reviewed, including our own work with a three-vector vaccination regimen using recombinant DNA, virus (Sendai virus or vaccinia virus and protein. Promising preliminary results suggest that the heterologous prime-boost strategy may possibly provide a foundation for the future prevention of HIV-1 infections in humans.

  4. A yeast model for target-primed (non-LTR retrotransposition

    Directory of Open Access Journals (Sweden)

    Busby Jason N

    2007-08-01

    Full Text Available Abstract Background Target-primed (non-LTR retrotransposons, such as the human L1 element, are mobile genetic elements found in many eukaryotic genomes. They are often present in large numbers and their retrotransposition can cause mutations and genomic rearrangements. Despite their importance, many aspects of their replication are not well understood. Results We have developed a yeast model system for studying target-primed retrotransposons. This system uses the Zorro3 element from Candida albicans. A cloned copy of Zorro3, tagged with a retrotransposition indicator gene, retrotransposes at a high frequency when introduced into an appropriate C. albicans host strain. Retrotransposed copies of the tagged element exhibit similar features to the native copies, indicating that the natural retrotransposition pathway is being used. Retrotransposition is dependent on the products of the tagged element's own genes and is highly temperature-regulated. The new assay permits the analysis of the effects of specific mutations introduced into the cloned element. Conclusion This Zorro3 retrotransposition assay system complements previously available target-primed retrotransposition assays. Due to the relative simplicity of the growth, manipulation and analysis of yeast cells, the system should advance our understanding of target-primed retrotransposition.

  5. Prime Incision and Modified Moving Window: A Minimally Invasive Access for Breast Cancer Surgical Treatment

    OpenAIRE

    E. Bromberg, Silvio; Giordano, Roberto

    2016-01-01

    BACKGROUND Conservative surgical treatment has been the treatment of choice for early breast cancer. It allows feasible oncological treatment with a satisfactory cosmetic approach and fast recovery. However, in some cases mastectomy is necessary. This study proposes a surgical approach with only one surgical access through the same incision, which is in line with precepts mentioned above. It is called the prime incision and modified moving window techniques. METHODS Thirty one patients with a...

  6. State of the art in advanced endoscopic imaging for the detection and evaluation of dysplasia and early cancer of the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Coda S

    2014-05-01

    Full Text Available Sergio Coda,1,2 Andrew V Thillainayagam1,2 1Section of Gastroenterology and Hepatology, Department of Medicine and Photonics Group, Department of Physics, Imperial College London, London, UK; 2Endoscopy Unit, Charing Cross Hospital, Imperial College Healthcare NHS Trust, London, UK Abstract: Ideally, endoscopists should be able to detect, characterize, and confirm the nature of a lesion at the bedside, minimizing uncertainties and targeting biopsies and resections only where necessary. However, under conventional white-light inspection – at present, the sole established technique available to most of humanity – premalignant conditions and early cancers can frequently escape detection. In recent years, a range of innovative techniques have entered the endoscopic arena due to their ability to enhance the contrast of diseased tissue regions beyond what is inherently possible with standard white-light endoscopy equipment. The aim of this review is to provide an overview of the state-of-the-art advanced endoscopic imaging techniques available for clinical use that are impacting the way precancerous and neoplastic lesions of the gastrointestinal tract are currently detected and characterized at endoscopy. The basic instrumentation and the physics behind each method, followed by the most influential clinical experience, are described. High-definition endoscopy, with or without optical magnification, has contributed to higher detection rates compared with white-light endoscopy alone and has now replaced ordinary equipment in daily practice. Contrast-enhancement techniques, whether dye-based or computed, have been combined with white-light endoscopy to further improve its accuracy, but histology is still required to clarify the diagnosis. Optical microscopy techniques such as confocal laser endomicroscopy and endocytoscopy enable in vivo histology during endoscopy; however, although of invaluable assistance for tissue characterization, they have not

  7. Imbibitions, energy test and accelerated ageing in primed and non-primed seeds of Peltophorum dubium

    Institute of Scientific and Technical Information of China (English)

    LILei-hong; ZHANGWan-li; ZUYuan-gang; SONIAPerez

    2005-01-01

    Peltophorum dubium seeds were set to imbibe with four treatments, soaked with solution Captan 0.2% under 10and 27℃,PEG 6000 -1.0 MPa under 10 and 27℃. For each treatment there were four replicates with 40 seeds incubated in 9-cm Petri dishes with double filter paper moistened with testing solution. The imbibition curves showed that the final weight increase were from 70% to 150% in the treatments when imbibition entered a lag phase. Seeds were tested for effects on germination of five treatments: control group (nonprimed), primed with PEG6000 -1.0 MPa at 10 and 27℃, primed with Captan 0.2% at 10 and 27℃. For each treatment, there were three sub-treatments: seeds were soaked in distilled water for 12, 24 and 36h before the energy test. Germination percentages of nonprimed seeds and primed in PEG 27℃ soaked in distilled water during 12 h were the highest, reaching 100%. The lowest germination percentage occurred primed seeds with PEG6000 27℃ and soaked in distilled water during 36 h, which was only 52%. Germination mean time of primed seeds in PEG at 10℃, soaked 24 h was 1.08 days, mean time of primed seeds in PEG at 27℃ soaked 12 h was 2.42 days. Accelerated ageing results showed low or no germination after ageing 72 h. Control group had a higher germination percentage and seeds were more resistant to deterioration than those in primed groups, both in Petri dish (27℃) and vermiculate (room temperature).

  8. Quantum Field Theories and Prime Numbers Spectrum

    CERN Document Server

    Menezes, G

    2012-01-01

    The Riemann hypothesis states that all nontrivial zeros of the zeta function lie on the critical line $\\Re(s)=1/2$. Hilbert and P\\'olya suggested a possible approach to prove it, based on spectral theory. Within this context, some authors formulated the question: is there a quantum mechanical system related to the sequence of prime numbers? In this Letter we assume that there is a class of hypothetical physical systems described by self-adjoint operators with countable infinite number of degrees of freedom with spectra given by the sequence of primes numbers. We prove a no-go theorem. We show that the generating functional of connected Schwinger functions of such theories cannot be constructed.

  9. Density of Primes in -th Power Residues

    Indian Academy of Sciences (India)

    R Balasubramanian; Prem Prakash Pandey

    2013-02-01

    Given a prime number , a finite set of integers $S=\\{a_1,\\ldots,a_m\\}$ and many -th roots of unity $^{r_i}_l,i=1,\\ldots,m$ we study the distribution of primes in $\\mathbb{Q}(_l)$ such that the -th residue symbol of $a_i$ with respect to is $^{r_i}_l$, for all . We find out that this is related to the degree of the extension $\\mathbb{Q}\\left(a^{\\frac{1}{l}}_1,\\ldots,a^{\\frac{1}{l}}_m\\right)/\\mathbb{Q}$. We give an algorithm to compute this degree. Also we relate this degree to rank of a matrix obtained from $S=\\{a_1,\\ldots,a_m\\}$. This latter argument enables one to describe the degree $\\mathbb{Q}\\left(a^{\\frac{1}{l}}_1,\\ldots,a^{\\frac{1}{l}}_m\\right)/\\mathbb{Q}$ in much simpler terms.

  10. On the union of graded prime ideals

    Directory of Open Access Journals (Sweden)

    Uregen Rabia Nagehan

    2016-01-01

    Full Text Available In this paper we investigate graded compactly packed rings, which is defined as; if any graded ideal I of R is contained in the union of a family of graded prime ideals of R, then I is actually contained in one of the graded prime ideals of the family. We give some characterizations of graded compactly packed rings. Further, we examine this property on h – Spec(R. We also define a generalization of graded compactly packed rings, the graded coprimely packed rings. We show that R is a graded compactly packed ring if and only if R is a graded coprimely packed ring whenever R be a graded integral domain and h – dim R = 1.

  11. Prime-Minister of Malta visits CERN

    CERN Multimedia

    2008-01-01

    The Prime-Minister of Malta, Dr Lawrence Gonzi, visited CERN and met Director-General, Robert Aymar, on 10 January. The Prime-Minister of Malta, Dr Lawrence Gonzi, and CERN Director-General, Robert Aymar, signed a cooperation agreement. Dr Gonzi was given guided tours of the CMS experiment at Point 5 in Cessy and of the LHC magnet test facility, in which his country was involved. One of the high points of the day was the signing of a cooperation agreement between CERN and the Government of the Republic of Malta, aimed at the development of scientific and technical collaboration. "I’m really enthusiastic about this agreement, which constitutes a first step towards real collaboration between the Maltese government and CERN," said Nicholas Sammut, a Maltese engineer at CERN who was present throughout the visit (on the right). See also the video.

  12. Long and Short Term Cumulative Structural Priming Effects.

    Science.gov (United States)

    Kaschak, Michael P; Kutta, Timothy J; Coyle, Jacqueline M

    We present six experiments that examine cumulative structural priming effects (i.e., structural priming effects that accumulate across many utterances). Of particular interest is whether (1) cumulative priming effects transfer across language production tasks and (2) the transfer of cumulative priming effects across tasks persists over the course of a week. Our data suggest that cumulative structural priming effects do transfer across language production tasks (e.g., from written stem completion to picture description, and from picture description to written stem completion), but only when both tasks are presented in the same experimental session. When cumulative priming effects are established in one task, and the second (changed) task is not presented until a week later, the cumulative priming effects are not observed.

  13. A negative compatibility effect in priming of emotional faces.

    Science.gov (United States)

    Bennett, Jennifer D; Lleras, Alejandro; Oriet, Chris; Enns, James T

    2007-10-01

    The negative compatibility effect (NCE) is the surprising result that low-visibility prime arrows facilitate responses to opposite-direction target arrows. Here we compare the priming obtained with simple arrows to the priming of emotions when categorizing human faces, which represents a more naturalistic set of stimuli and for which there are no preexisting response biases. When inverted faces with neutral expressions were presented alongside emotional prime and target faces, only strong positive priming occurred. However, when the neutral faces were made to resemble the target faces in geometry (upright orientation), time (flashing briefly), and space (appearing in the same location), positive priming gradually weakened and became negative priming. Implications for theories of the NCE are discussed.

  14. Prime rings with PI rings of constants

    CERN Document Server

    Kharchenko, V K; Rodríguez-Romo, S

    1996-01-01

    It is shown that if the ring of constants of a restricted differential Lie algebra with a quasi-Frobenius inner part satisfies a polynomial identity (PI) then the original prime ring has a generalized polynomial identitiy (GPI). If additionally the ring of constants is semiprime then the original ring is PI. The case of a non-quasi-Frobenius inner part is also considered.

  15. Priming Cooperation in Social Dilemma Games

    OpenAIRE

    Drouvelis, Michalis; Metcalfe, Robert; Powdthavee, Nattavudh

    2010-01-01

    Research on public goods mainly focuses its attention on the ability of incentives, beliefs and group structure to affect behaviour in social dilemma interactions. This paper investigates the pure effects of a rather subtle mechanism on social preferences in a one-shot linear public good game. Using priming techniques from social psychology, we activate the concept of cooperation and explore the extent to which this intervention brings about changes in people’s voluntary contributions to the ...

  16. Emotional arousal enhances word repetition priming

    OpenAIRE

    Thomas, Laura A.; LaBar, Kevin S.

    2005-01-01

    Three experiments were conducted to determine if emotional content increases repetition priming magnitude. In the study phase of Experiment 1, participants rated high-arousing negative (taboo) words and neutral words for concreteness. In the test phase, they made lexical decision judgements for the studied words intermixed with novel words (half taboo, half neutral) and pseudowords. In Experiment 2, low-arousing negative (LAN) words were substituted for the taboo words, and in Experiment 3 al...

  17. Semantic Priming from Letter-Searched Primes Occurs for Low- but Not High-Frequency Targets: Automatic Semantic Access May Not Be a Myth

    Science.gov (United States)

    Tse, Chi-Shing; Neely, James H.

    2007-01-01

    Letter-search (LS) within a prime often eliminates semantic priming. In 2 lexical decision experiments, the authors found that priming from LS primes occurred for low-frequency (LF) but not high-frequency (HF) targets whether the target's word frequency was manipulated between or within participants and whether the prime-target pairs were…

  18. Adult attachment orientation and automatic processing of emotional information on a semantic level: A masked affective priming study.

    Science.gov (United States)

    Donges, Uta-Susan; Zeitschel, Frank; Kersting, Anette; Suslow, Thomas

    2015-09-30

    Early adverse social experiences leading to attachment insecurity could cause heightened sensitivity to emotional information. Automatic processing of emotional stimuli conveys information about positive-negative differentiation and the so-called possessor vs. other-relevance of valence. The aim of the present study was to examine automatic processing of emotional and relevance type information on a semantic level as a function of adult attachment avoidance and anxiety. A masked affective priming task, varying valence and relevance of prime and target adjectives, was presented to a sample of 153 healthy adults. The Experiences in Close Relationships scale was administered to assess attachment orientation. Significant priming effects for valence and relevance were observed. Attachment avoidance, but not attachment anxiety, was significantly related to affective priming independently of trait anxiety and depression. Specifically, attachment avoidance was found to be related to affective priming effects based on other-relevant words. It can be concluded that automatic processing of emotional adjectives used to characterize safe or risky social environments is heightened in avoidant individuals. The avoidantly attached processing style has similarities with repressive coping, which is characterized by an enhanced early response to emotion stimuli followed by avoidant biases at a controlled processing level.

  19. Resistance of a directionally solidified gamma/gamma prime-delta eutectic alloy to recrystallization. [Ni-base alloy

    Science.gov (United States)

    Tewari, S. N.; Scheuermann, C. M.; Andrews, C. W.

    1976-01-01

    A lamellar nickel-base directionally-solidified eutectic gamma/gamma prime-delta alloy has potential as an advanced gas turbine blade material. The microstructural stability of this alloy was investigated. Specimens were plastically deformed by uniform compression or Brinell indentation, then annealed between 750 and 1120 C. Microstructural changes observed after annealing included gamma prime coarsening, pinch-off and spheroidization of delta lamellae, and appearance of an unidentified blocky phase in surface layers. All but the first of these was localized in severely deformed regions, suggesting that microstructural instability may not be a serious problem in the use of this alloy.

  20. Excessive attractor instability accounts for semantic priming in schizophrenia.

    Directory of Open Access Journals (Sweden)

    Itamar Lerner

    Full Text Available One of the most pervasive findings in studies of schizophrenics with thought disorders is their peculiar pattern of semantic priming, which presumably reflects abnormal associative processes in the semantic system of these patients. Semantic priming is manifested by faster and more accurate recognition of a word-target when preceded by a semantically related prime, relative to an unrelated prime condition. Compared to control, semantic priming in schizophrenics is characterized by reduced priming effects at long prime-target Stimulus Onset Asynchrony (SOA and, sometimes, augmented priming at short SOA. In addition, unlike controls, schizophrenics consistently show indirect (mediated priming (such as from the prime 'wedding' to the target 'finger', mediated by 'ring'. In a previous study, we developed a novel attractor neural network model with synaptic adaptation mechanisms that could account for semantic priming patterns in healthy individuals. Here, we examine the consequences of introducing attractor instability to this network, which is hypothesized to arise from dysfunctional synaptic transmission known to occur in schizophrenia. In two simulated experiments, we demonstrate how such instability speeds up the network's dynamics and, consequently, produces the full spectrum of priming effects previously reported in patients. The model also explains the inconsistency of augmented priming results at short SOAs using directly related pairs relative to the consistency of indirect priming. Further, we discuss how the same mechanism could account for other symptoms of the disease, such as derailment ('loose associations' or the commonly seen difficulty of patients in utilizing context. Finally, we show how the model can statistically implement the overly-broad wave of spreading activation previously presumed to characterize thought-disorders in schizophrenia.

  1. Interlateral asymmetry in the time course of the effect of a peripheral prime stimulus.

    Science.gov (United States)

    Castro-Barros, B A; Righi, L L; Grechi, G; Ribeiro-do-Valle, L E

    2008-04-01

    Evidence exists that both right and left hemisphere attentional mechanisms are mobilized when attention is directed to the right visual hemifield and only right hemisphere attentional mechanisms are mobilized when attention is directed to the left visual hemifield. This arrangement might lead to a rightward bias of automatic attention. The hypothesis was investigated by testing male volunteers, wherein a "location discrimination" reaction time task (Experiments 1 and 3) and a "location and shape discrimination" reaction time task (Experiments 2 and 4) were used. Unilateral (Experiments 1 and 2) and unilateral or bilateral (Experiments 3 and 4) peripheral visual prime stimuli were used to control attention. Reaction time to a small visual target stimulus in the same location or in the horizontally opposite location was evaluated. Stimulus onset asynchronies (SOAs) were 34, 50, 67, 83 and 100 ms. An important prime stimulus attentional effect was observed as early as 50 ms in the four experiments. In Experiments 2, 3 and 4, this effect was larger when the prime stimulus occurred in the right hemifield than when it occurred in the left hemifield for SOA 100 ms. In Experiment 4, when the prime stimulus occurred simultaneously in both hemifields, reaction time was faster for the right hemifield and for SOA 100 ms. These results indicate that automatic attention tends to favor the right side of space, particularly when identification of the target stimulus shape is required.

  2. Mechanisms of masked evaluative priming: Task sets modulate behavioral and electrophysiological priming for picture and words differentially.

    Science.gov (United States)

    Kiefer, Markus; Liegel, Nathalie; Zovko, Monika; Wentura, Dirk

    2016-12-20

    Research with the evaluative priming paradigm has shown that affective evaluation processes reliably influence cognition and behavior, even when triggered outside awareness. However, the precise mechanisms underlying such subliminal evaluative priming effects, response activation vs. semantic processing, are matter of a debate. In the present study, we determined the relative contribution of semantic processing and response activation to masked evaluative priming with pictures and words. To this end, we investigated the modulation of masked pictorial vs. verbal priming by previously activated perceptual versus semantic task sets and assessed the electrophysiological correlates of priming using event-related potential (ERP) recordings. Behavioral and electrophysiological effects showed a differential modulation of pictorial and verbal subliminal priming by previously activated task sets: Pictorial priming was only observed during the perceptual but not during the semantic task set. Verbal priming, in contrast, was found when either task set was activated. Furthermore, only verbal priming was associated with a modulation of the N400 ERP component, an index of semantic processing, whereas a priming-related modulation of earlier ERPs, indexing visuo-motor S-R activation, was found for both picture and words. The results thus demonstrate that different neuro-cognitive processes contribute to unconscious evaluative priming depending on the stimulus format.

  3. The masked priming toolbox: an open-source MATLAB toolbox for masked priming researchers.

    Science.gov (United States)

    Wilson, Andrew D; Tresilian, James; Schlaghecken, Friederike

    2011-03-01

    The Masked Priming Toolbox is an open-source collection of MATLAB functions that utilizes the free third-party PsychToolbox-3 (PTB3: Brainard, Spatial Vision, 10, 433-436, 1997; Kleiner, Brainard & Pelli, Perception, 36, 2007; Pelli, Spatial Vision, 10, 437-442, 1997). It is designed to allow a researcher to run masked (and unmasked) priming experiments using a variety of response devices (including keyboards, graphics tablets and force transducers). Very little knowledge of MATLAB is required; experiments are generated by creating a text file with the required parameters, and raw and analyzed data are output to Excel (as well as MATLAB) files for further analysis. The toolbox implements a variety of stimuli for use as primes and targets, as well as a variety of masks. Timing, size, location, and orientation of stimuli are all parameterizable. The code is open-source and made available on the Web under a Creative Commons License.

  4. The nature of affective priming in music and speech.

    Science.gov (United States)

    Goerlich, Katharina Sophia; Witteman, Jurriaan; Schiller, Niels O; Van Heuven, Vincent J; Aleman, André; Martens, Sander

    2012-08-01

    The phenomenon of affective priming has caught scientific interest for over 30 years, yet the nature of the affective priming effect remains elusive. This study investigated the underlying mechanism of cross-modal affective priming and the influence of affective incongruence in music and speech on negativities in the N400 time-window. In Experiment 1, participants judged the valence of affective targets (affective categorization). We found that music and speech targets were evaluated faster when preceded by affectively congruent visual word primes, and vice versa. This affective priming effect was accompanied by a significantly larger N400-like effect following incongruent targets. In this experiment, both spreading of activation and response competition could underlie the affective priming effect. In Experiment 2, participants categorized the same affective targets based on nonaffective characteristics. However, as prime valence was irrelevant to the response dimension, affective priming effects could no longer be attributable to response competition. In Experiment 2, affective priming effects were observed neither at the behavioral nor electrophysiological level. The results of this study indicate that both affective music and speech prosody can prime the processing of visual words with emotional connotations, and vice versa. Affective incongruence seems to be associated with N400-like effects during evaluative categorization. The present data further suggest a role of response competition during the affective categorization of music, prosody, and words with emotional connotations.

  5. How Orthography Modulates Morphological Priming: Subliminal Kanji Activation in Japanese

    Science.gov (United States)

    Nakano, Yoko; Ikemoto, Yu; Jacob, Gunnar; Clahsen, Harald

    2016-01-01

    The current study investigates to what extent masked morphological priming is modulated by language-particular properties, specifically by its writing system. We present results from two masked priming experiments investigating the processing of complex Japanese words written in less common (moraic) scripts. In Experiment 1, participants performed lexical decisions on target verbs; these were preceded by primes which were either (i) a past-tense form of the same verb, (ii) a stem-related form with the epenthetic vowel -i, (iii) a semantically-related form, and (iv) a phonologically-related form. Significant priming effects were obtained for prime types (i), (ii), and (iii), but not for (iv). This pattern of results differs from previous findings on languages with alphabetic scripts, which found reliable masked priming effects for morphologically related prime/target pairs of type (i), but not for non-affixal and semantically-related primes of types (ii), and (iii). In Experiment 2, we measured priming effects for prime/target pairs which are neither morphologically, semantically, phonologically nor - as presented in their moraic scripts—orthographically related, but which—in their commonly written form—share the same kanji, which are logograms adopted from Chinese. The results showed a significant priming effect, with faster lexical-decision times for kanji-related prime/target pairs relative to unrelated ones. We conclude that affix-stripping is insufficient to account for masked morphological priming effects across languages, but that language-particular properties (in the case of Japanese, the writing system) affect the processing of (morphologically) complex words. PMID:27065895

  6. How Orthography Modulates Morphological Priming: Subliminal Kanji Activation in Japanese.

    Science.gov (United States)

    Nakano, Yoko; Ikemoto, Yu; Jacob, Gunnar; Clahsen, Harald

    2016-01-01

    The current study investigates to what extent masked morphological priming is modulated by language-particular properties, specifically by its writing system. We present results from two masked priming experiments investigating the processing of complex Japanese words written in less common (moraic) scripts. In Experiment 1, participants performed lexical decisions on target verbs; these were preceded by primes which were either (i) a past-tense form of the same verb, (ii) a stem-related form with the epenthetic vowel -i, (iii) a semantically-related form, and (iv) a phonologically-related form. Significant priming effects were obtained for prime types (i), (ii), and (iii), but not for (iv). This pattern of results differs from previous findings on languages with alphabetic scripts, which found reliable masked priming effects for morphologically related prime/target pairs of type (i), but not for non-affixal and semantically-related primes of types (ii), and (iii). In Experiment 2, we measured priming effects for prime/target pairs which are neither morphologically, semantically, phonologically nor - as presented in their moraic scripts-orthographically related, but which-in their commonly written form-share the same kanji, which are logograms adopted from Chinese. The results showed a significant priming effect, with faster lexical-decision times for kanji-related prime/target pairs relative to unrelated ones. We conclude that affix-stripping is insufficient to account for masked morphological priming effects across languages, but that language-particular properties (in the case of Japanese, the writing system) affect the processing of (morphologically) complex words.

  7. How Orthography Modulates Morphological Priming: Subliminal Kanji Activation in Japanese

    Directory of Open Access Journals (Sweden)

    Yoko eNakano

    2016-03-01

    Full Text Available The current study investigates to what extent masked morphological priming is modulated by language-particular properties, specifically by its writing system. We present results from two masked priming experiments investigating the processing of complex Japanese words written in less common (moraic scripts. In Experiment 1, participants performed lexical decisions on target verbs; these were preceded by primes which were either (i a past-tense form of the same verb, (ii a stem-related form with the epenthetic vowel -i, (iii a semantically-related form, and (iv a phonologically-related form. Significant priming effects were obtained for prime types (i, (ii and (iii, but not for (iv. This pattern of results differs from previous findings on languages with alphabetic scripts, which found reliable masked priming effects for morphologically related prime/target pairs of type (i, but not for non-affixal and semantically-related primes of types (ii and (iii. In Experiment 2, we measured priming effects for prime/target pairs which are neither morphologically, semantically, phonologically nor - as presented in their moraic scripts – orthographically related, but which - in their commonly written form - share the same kanji, which are logograms adopted from Chinese. The results showed a significant priming effect, with faster lexical-decision times for kanji-related prime/target pairs relative to unrelated ones. We conclude that affix-stripping is insufficient to account for masked morphological priming effects across languages, but that language-particular properties (in the case of Japanese, the writing system affect the processing of (morphologically complex words.

  8. Analysis of the Channel Influence to Power Line Communications Based on ITU-T G.9904 (PRIME

    Directory of Open Access Journals (Sweden)

    Asier Llano

    2016-01-01

    Full Text Available ITU-T G.9904 standard, also known as PoweRline Intelligent Metering Evolution (PRIME, is a Power Line Communications standard for advanced metering, grid control and asset monitoring defined by the International Telecommunication Union (ITU. In this paper, an analysis about how different characteristics of the communication channel and types of noise might affect the system performance is carried out. This study is based on simulations of the PRIME physical layer using different channel characteristics and transmission parameters. The conclusions obtained are very valuable for better understanding the behavior of the ITU-T G.9904 (PRIME standard in the field, allowing future improvements in deployment strategies and equipment design.

  9. The system software development for Prime Focus Spectrogrsph on Subaru Telescope

    CERN Document Server

    ,

    2012-01-01

    The Prime Focus Spectrograph (PFS) is a wide field multi-fiber spectrograph using the prime focus of the Subaru telescope, which is capable of observing up to 2400 astronomical objects simultaneously. The instrument control software will manage the observation procedure communicateing with subsystems such as the fiber positioner "COBRA", the metrology camera system, and the spectrograph and camera systems. Before an exposure starts, the instrument control system needs to access to a database where target lists provided by observers are stored in advance, and accurately position fibers onto astronomical targets as requested therein. This fiber positioning will be carried out interacting with the metrology system which measures the fiber positions. In parallel, the control system can issue a command to point the telescope to the target position and to rotate the instrument rotator. Finally the telescope pointing and the rotator angle will be checked by imaging bright stars and checking their positions on the au...

  10. A large N400 but no BOLD effect--comparing source activations of semantic priming in simultaneous EEG-fMRI.

    Directory of Open Access Journals (Sweden)

    Sebastian Geukes

    Full Text Available Numerous studies have reported neurophysiological effects of semantic priming in electroencephalography (EEG and in functional magnetic resonance imaging (fMRI. Because of differing methodological constraints, the comparability of the observed effects remains unclear. To directly compare EEG and fMRI effects and neural sources of semantic priming, we conducted a semantic word-picture priming experiment while measuring EEG and fMRI simultaneously. The visually presented primes were pseudowords, words unrelated to the target, semantically related words and the identical names of the target. Distributed source analysis of the event-related potentials (ERPs successfully revealed a large effect of semantic prime-target relatedness (the N400 effect, which was driven by activations in a left-temporal source region. However, no significantly differing activations between priming conditions were found in the fMRI data. Our results support the notion that, for joint interpretations of existing EEG and fMRI studies of semantic priming, we need to fully appreciate the respective methodological limitations. Second, they show that simultaneous EEG-fMRI, including ERP source localization, is a feasible and promising methodological advancement for the investigation of higher-cognitive processes. Third, they substantiate the finding that, compared to fMRI, ERPs are often more sensitive to subtle cognitive effects.

  11. Patterns of Experience with Verbs Affect Long-Term Cumulative Structural Priming

    OpenAIRE

    Coyle, Jacqueline M.; Kaschak, Michael P.

    2008-01-01

    Recent studies of structural priming have demonstrated that although there is evidence of verb-based effects in short-term priming (e.g., stronger priming when verbs are repeated between prime and target sentences), such effects are absent in long-term priming. We present evidence that verb-based effects can be observed in longterm priming situations. This result has important implications for theoretical accounts of the mechanisms that give rise to structural priming and other such adaptatio...

  12. Word-identification priming for ignored and attended words

    Science.gov (United States)

    Stone, M.; Ladd, S. L.; Vaidya, C. J.; Gabrieli, J. D.

    1998-01-01

    Three experiments examined contributions of study phase awareness of word identity to subsequent word-identification priming by manipulating visual attention to words at study. In Experiment 1, word-identification priming was reduced for ignored relative to attended words, even though ignored words were identified sufficiently to produce negative priming in the study phase. Word-identification priming was also reduced after color naming relative to emotional valence rating (Experiment 2) or word reading (Experiment 3), even though an effect of emotional valence upon color naming (Experiment 2) indicated that words were identified at study. Thus, word-identification priming was reduced even when word identification occurred at study. Word-identification priming may depend on awareness of word identity at the time of study.

  13. Muskmelon seed priming in relation to seed vigor

    Directory of Open Access Journals (Sweden)

    Nascimento Warley Marcos

    2004-01-01

    Full Text Available A number of important factors may affect seed priming response, including seed quality. Effects of seed vigor on seed priming response were investigated using seed lots of two muskmelon (Cucumis melo L. cultivars. Seeds of muskmelon, cvs. Mission and Top Net SR were artificially aged at 43°C for 0, 20 and 40 hours. Seeds were primed for six days in darkness at 25°C in KNO3 (0.35 mol L-1 aerated solution. Aged seeds germinated poorly at 17°C. Priming increased germination rate at 17 and 25°C and germination percentage at 17°C. An interaction effect on germination performance between vigor and priming was observed, especially at low temperature. Priming increased germination performance in seeds of low vigor, and the response was cultivar dependent.

  14. On the Distribution of Atkin and Elkies Primes

    CERN Document Server

    Shparlinski, Igor E

    2011-01-01

    Given an elliptic curve E over a finite field F_q of q elements, we say that a prime ell not dividing q is an Elkies prime for E if t_E^2 - 4q is a square modulo ell, where t_E = q+1 - #E(F_q) and #E(F_q) is the number of F_q-rational points on E; otherwise ell is called an Atkin prime. We show that there are asymptotically the same number of Atkin and Elkies primes ell = (log q)^e for any fixed e > 0 and a sufficiently large q. We use this result to design and analyse a fast algorithm to generate random elliptic curves with #E(F_p) prime, where p varies uniformly over primes in a given interval [x,2x].

  15. Phonology in the Lexical Processing of Chinese: Priming Tone Neighbors

    Institute of Scientific and Technical Information of China (English)

    Zhou Xiaolin

    2000-01-01

    Using both visual-visual and auditory-visual priming lexical decision tasks, this study investigated phonological processing in reading logographic Chinese. Compound words sharing segmental templates but differing in lexical tones were used as primes and targets while their relative frequency was manipulated. It was found that tone neighbours did not prime each other significantly and the SOA of 100 msec in visual-visual priming. When the SOA was increased to 357 msec, or when primes were presented auditorily, the processing of target words was significantly delayed by their tone neighbours. Larger inhibitory effects were observed for low frequency targets with high frequency primes. It was argued that although phonological information is automatically activated and this activation affects access to semantics in reading Chinese,phonological mediation is not the only or the main ~urce of constraints on semantic activation.

  16. Word-identification priming for ignored and attended words

    Science.gov (United States)

    Stone, M.; Ladd, S. L.; Vaidya, C. J.; Gabrieli, J. D.

    1998-01-01

    Three experiments examined contributions of study phase awareness of word identity to subsequent word-identification priming by manipulating visual attention to words at study. In Experiment 1, word-identification priming was reduced for ignored relative to attended words, even though ignored words were identified sufficiently to produce negative priming in the study phase. Word-identification priming was also reduced after color naming relative to emotional valence rating (Experiment 2) or word reading (Experiment 3), even though an effect of emotional valence upon color naming (Experiment 2) indicated that words were identified at study. Thus, word-identification priming was reduced even when word identification occurred at study. Word-identification priming may depend on awareness of word identity at the time of study.

  17. A clinic-based youth development program to reduce sexual risk behaviors among adolescent girls: prime time pilot study.

    Science.gov (United States)

    Sieving, Renee E; Bernat, Debra H; Resnick, Michael D; Oliphant, Jennifer; Pettingell, Sandra; Plowman, Shari; Skay, Carol

    2012-07-01

    Multifaceted, sustained efforts are needed to reduce early pregnancy and sexually transmitted diseases among high-risk adolescents. An important area for research is testing youth development interventions offered through clinic settings, where access to high-risk adolescents is plentiful and few efforts have rigorously evaluated a dual approach of building protective factors while addressing risk. This article presents findings from a pilot study of Prime Time, a clinic-based youth development intervention to reduce sexual risk behaviors among girls at risk for early pregnancy. Girls aged 13 to 17 years meeting specified risk criteria were assigned to Prime Time treatment groups. The Prime Time intervention included a combination of case management services and peer leadership groups. Participants completed self-report surveys at baseline, 12 and 18 months following enrollment. At 12 months, the intervention group reported significantly fewer sexual partners than the control group. At 18 months, the intervention group reported significantly more consistent condom use with trends toward more consistent hormonal and dual method use. Dose-response analyses suggested that relatively high levels of exposure to a youth development intervention were needed to change contraceptive use behaviors among adolescents at risk for early pregnancy. Given promising findings, further testing of the Prime Time intervention is warranted.

  18. The n-th prime asymptotically

    CERN Document Server

    de Reyna, Juan Arias

    2012-01-01

    A new derivation of the classic asymptotic expansion of the n-th prime is presented. A fast algorithm for the computation of its terms is also given, which will be an improvement of that by Salvy (1994). Realistic bounds for the error with $\\li^{-1}(n)$, after having retained the first m terms, for $1\\le m\\le 11$, are given. Finally, assuming the Riemann Hypothesis, we give estimations of the best possible $r_3$ such that, for $n\\ge r_3$, we have $p_n> s_3(n)$ where $s_3(n)$ is the sum of the first four terms of the asymptotic expansion.

  19. Notes on Automorphisms of Prime Rings

    Institute of Scientific and Technical Information of China (English)

    Huang Shu-liang; Du Xian-kun

    2015-01-01

    Let Rbe a prime ring, L a noncentral Lie ideal and σ a nontrivial automorphism of Rsuch that usσ(u)ut = 0 for all u ∈ L, where s, t are fixed non-negative integers. If either charR>s+t or charR=0, then Rsatisfies s4, the standard identity in four variables. We also examine the identity (σ([x, y])−[x, y])n=0 for all x, y∈I, where I is a nonzero ideal of Rand n is a fixed positive integer. If either charR>n or charR=0, then Ris commutative.

  20. ACME Priority Metrics (A-PRIME)

    Energy Technology Data Exchange (ETDEWEB)

    2017-06-08

    A-PRIME, is a collection of scripts designed to provide Accelerated Climate Model for Energy (ACME) model developers and analysts with a variety of analysis of the model needed to determine if the model is producing the desired results, depending on the goals of the simulation. The software is csh scripts based at the top level to enable scientist to provide the input parameters. Within the scripts, the csh scripts calls code to perform the postprocessing of the raw data analysis and create plots for visual assessment.