WorldWideScience

Sample records for early perimenopausal women

  1. Clinicopathological evaluation of abnormal uterine bleeding in perimenopausal women

    Directory of Open Access Journals (Sweden)

    Lithingo Lotha

    2016-09-01

    Conclusions: Clinicopathological evaluation of AUB showed that fibroid uterus followed by DUB is the most common cause in perimenopausal women. Occurrences of endometrial hyperplasia increases in perimenopause which is of great value as it is a forerunner of carcinoma. [Int J Reprod Contracept Obstet Gynecol 2016; 5(9.000: 3072-3074

  2. Subjective sleep quality in perimenopausal women and its related factors

    Institute of Scientific and Technical Information of China (English)

    Jianping Zhang; Fen Lia; Yongjie Lin; Qiu Sheng; Xuewen Yu; Xinwen Zhang

    2007-01-01

    Objective: To evaluate the sleep quality and its related factors among perimenopausal women. Methods: A self-designed questionnaire was administered to 506 perimenopausal women. The questionnaire included the influencing factors on the sleep quality, the Pittsburgh Sleep Quality Index (PSQI), the Zung Self-Rating Depression Scales (SDS), the Zung Self-Rating Anxiety (SAS) and the Modified Kupperman Index (KI). Data were analyzed by SPSS11.5. Results: The mean PSQI was 5.97±4.30.Twenty-four percent of perimenopausal women reported poor sleep. Age and perimenopausal symptoms were significantly correlated with sleep quality. The sleep quality of the 45~49 age group was the poorest and the 40~44 age group was the best. The women who had higher Kupperman index were more likely to be poor sleepers. There was no significant correlation between occupation and sleep quality. Night sweat, depression, anxiety, hot flash, stressful life event, and regular exercise were significantly and independently related with sleep quality. Among them, regular exercise was a protective factor of sleep quality. Conclusion:High incidence of poor sleep quality exists among perimenopausal women. Some effective interventions should be taken to improve the sleep quality of perimenopausal women.

  3. Breast cancer after hormone replacement therapy--does prognosis differ in perimenopausal and postmenopausal women?

    Science.gov (United States)

    Baumgärtner, A K; Häusler, A; Seifert-Klauss, V; Schuster, T; Schwarz-Boeger, U; Kiechle, M

    2011-10-01

    Hormone replacement therapy (HRT) has been associated with higher incidence of breast cancer in postmenopausal women, but it is unclear if breast cancers developing after HRT use have different prognosis. 1053 women with hormone receptor positive non-metastasized breast cancer were analyzed in a retrospective trial, stratifying by HRT use before diagnosis. Postmenopausal HRT users had significantly more early tumor stages (pprognosis in perimenopausal women only (TTP: HR=1.16; OS: HR=1.31). In this retrospective analysis postmenopausal HRT users seemed to have a better breast cancer prognosis. For perimenopausal HRT users however, a trend towards worse prognosis was found.

  4. Eating disorders in midlife women: A perimenopausal eating disorder?

    Science.gov (United States)

    Baker, Jessica H; Runfola, Cristin D

    2016-03-01

    Eating disorders afflict women across the lifespan with peak onset during critical or sensitive developmental periods of reproductive hormone change, such as puberty. A growing body of research supports the role of reproductive hormones, specifically estrogen, in the risk for eating disorders and related symptomatology in adolescence and young adulthood. Like puberty, perimenopause is characterized by estrogen change and may also present a window of vulnerability to eating disorder development. Here, we discuss the evidence that suggests perimenopause indeed may be a vulnerable period for the development or redevelopment of an eating disorder for midlife women. Drawing from what is known about the influence of estrogen on eating disorders at younger ages and from other psychiatric disorders with similar risk trajectories (i.e., perimenopausal depression), we describe a potential mechanism of risk for a perimenopausal eating disorder and how this can be explored in future research. Investigating vulnerability to perimenopausal eating disorders will clarify eating disorder etiology, identify reproductive stage-specific risk profiles, and guide future treatment directions.

  5. The prevalence of low bone mineral density in Dutch perimenopausal women: the Eindhoven perimenopausal osteoporosis study.

    Science.gov (United States)

    Smeets-Goevaers, C G; Lesusink, G L; Papapoulos, S E; Maartens, L W; Keyzer, J J; Weerdenburg, J P; Beijers, L M; Zwinderman, A H; Knottnerus, J A; Pols, H A; Pop, V J

    1998-01-01

    The aim of this study was to estimate the prevalence of osteopenia and osteoporosis in perimenopausal women, and to assess determinants of low bone mineral density (BMD). All women born between 1941 and 1947 (aged between 46 and 54 years) living in the city of Eindhoven were invited to participate in the study: 5896 white Dutch women, representing 73% of the total number of Dutch women in this age group, were studied. Of these, 24% were using estrogen preparations and 19% had undergone hysterectomy, with or without oophorectomy. All women were interviewed and bone mineral density (BMD) of the lumbar spine was measured by dual-energy X-ray absorptiometry (DXA). Osteopenia and osteoporosis were defined according to the criteria proposed by a WHO working group. In the population studied the prevalence of osteopenia and osteoporosis was 27.3% and 4.1%, respectively. With progression from premenopause to menopause, the prevalence of osteoporosis increased from 0.4% to 12.7%, and that of osteopenia from 14.5% to 42.8%. An increased risk for low BMD (osteopenia and osteoporosis) was associated with age, menopausal status and smoking, while alcohol consumption, high body mass index (BMI) and use of estrogens had a protective effect. This study of a large population-based cohort of perimenopausal women revealed a high prevalence of low bone mass and, therefore, a higher risk for osteoporotic fractures. The data further suggest that, when issues on the long-term efficacy and safety of preventive treatments are resolved, it may be possible to identify women at higher risk who are most likely to benefit from screening strategies.

  6. Fracture risk in perimenopausal women treated with beta-blockers

    DEFF Research Database (Denmark)

    Rejnmark, Lars; Vestergaard, Peter; Kassem, Moustapha

    2004-01-01

    beta2-Adrenergic receptors have been identified on human osteoblastic and osteoclastic cells, raising the question of a sympathetic regulation of bone metabolism. We investigated effects of treatment with beta-adrenergic receptor antagonists (beta-blockers) on bone turnover, bone mineral density...... (BMD), and fracture risk. Within the Danish Osteoporosis Prevention Study (DOPS) a population based, comprehensive cohort study of 2016 perimenopausal women, associations between treatment with beta-blockers and bone turnover and BMD were assessed in a cross-sectional design at the start of study....... Moreover, in a nested case-control design, fracture risk during the subsequent 5 years was assessed in relation to treatment with beta-blockers at baseline. Multiple regression- and logistic regression-analyses were performed. Treatment with beta-blockers was associated with a threefold increased fracture...

  7. Thyroid abnormality in perimenopausal women with abnormal uterine bleeding

    Directory of Open Access Journals (Sweden)

    Prasanna Byna

    2015-11-01

    Full Text Available Background: AUB is a common but complicated clinical presentation and occurs in 15-20% of women between menarche to menopause and significantly affects the women's health. Women with thyroid dysfunction often have menstrual irregularities, infertility and increased morbidity during pregnancy. The objective of present study is to find the correlation between thyroid disorders and AUB in perimenopausal women attending gynecology OPD. Methods: In the present study, fifty five patients with AUB were included and were evaluated for the cause including thyroid abnormality. Thyroid function tests were done in all patients. Results: Among 55 patients, 12 patients were diagnosed as hypothyroidism and 7 as hyperthyroidism, women with AUB 36 (65.4% were euthyroid. Among 19 women with thyroid abnormality, heavy menstrual bleeding was seen in 8 (42% women, 6 (31.57% had polymenorrhagia, 5 (26.31% had oligomenorrhoea. The frequent menstrual abnormality in women with hypothyroidism (12 women was heavy menstrual bleeding in 5 (41.6% women, 3 (25% had oligomennorhoea, 4 (33.3% had polymenorrhagia. Out of 7 women with hyperthyroidism, 2 (28.57% had oligomenorrhoea, 3 (42.8% had heavy menstrual bleeding, 2 (28.57% had polymenorrhagia. In a total of 55 patients with AUB, 11 (20% had structural abnormalities in uterus and ovaries. 5 (9% had adenomyosis, 3 (5.4% had ovarian cysts, 3 (5.4% had fibroids. Conclusions: It is important to screen all women for thyroid abnormality who are presenting with AUB especially with non-structural causes of AUB. Correction of thyroid abnormalities also relieves AUB. This will avoid unnecessary hormonal treatment and surgery. [Int J Res Med Sci 2015; 3(11.000: 3250-3253

  8. Knowledge on Perimenopausal Symptoms among Women Attending Lumbini Medical College Teaching Hospital

    Directory of Open Access Journals (Sweden)

    Parbati Nepal Paudyal

    2014-12-01

    Full Text Available Introduction: Perimenopause is an unavoidable stage of a woman's reproductive life that starts several years before menopause. Due to declining estrogen level, women experience physiological and psychological changes during perimenopausal period and sometimes symptoms are very distressing that affect the women’s quality of life negatively. This study was done to assess the knowledge of women about perimenopausal symptoms. Methods: A cross-sectional analytical study was done at Lumbini Medical college (LMC throughout the months of November and December, 2013. Women of age 40-60 years, attending various clinics in LMC and ready to take part in the study were included. A total of 142 women were selected purposefully. The data was collected using the semi structured interview schedule. Results: The study revealed that half of respondents were between age group 40-44 years, 141 (99.3% were married and 82 (57.7% were literate. Three quarter of respondents (74.6% were menstruating women. The main source of information on perimenopausal symptoms was friends and relatives (81.2%. Majority of respondents (n=90, 63.4% had poor, 52 (33.8% had fair and only 2.8% had good level of knowledge on perimenopausal symptoms. The respondents’ level of knowledge on perimenopausal symptoms was statistically significant with educational status (p<0.001, level of education (p=0.048 and economic status (p=0.02. Conclusion: Many women have poor knowledge on perimenopausal symptoms. The role of health care provider is that they should seriously discuss about mid-life women’s health problems including perimenopausal symptoms and treatment modality including hormonal replacement therapy so the quality of life of women can be improved.

  9. Long-term hormone therapy for perimenopausal and postmenopausal women.

    Science.gov (United States)

    Marjoribanks, Jane; Farquhar, Cindy; Roberts, Helen; Lethaby, Anne; Lee, Jasmine

    2017-01-17

    BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. This is an updated version of a Cochrane review first published in 2005. OBJECTIVES: To assess effects of long-term HT (at least 1 year's duration) on mortality, cardiovascular outcomes, cancer, gallbladder disease, fracture and cognition in perimenopausal and postmenopausal women during and after cessation of treatment. SEARCH METHODS: We searched the following databases to September 2016: Cochrane Gynaecology and Fertility Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and PsycINFO. We searched the registers of ongoing trials and reference lists provided in previous studies and systematic reviews. SELECTION CRITERIA: We included randomised double-blinded studies of HT versus placebo, taken for at least 1 year by perimenopausal or postmenopausal women. HT included oestrogens, with or without progestogens, via the oral, transdermal, subcutaneous or intranasal route. DATA COLLECTION AND ANALYSIS: Two review authors independently selected studies, assessed risk of bias and extracted data. We calculated risk ratios (RRs) for dichotomous data and mean differences (MDs) for continuous data, along with 95% confidence intervals (CIs). We assessed the quality of the evidence by using GRADE methods. MAIN RESULTS: We included 22 studies involving 43,637 women. We derived nearly 70% of the data from two well-conducted studies (HERS 1998; WHI 1998). Most participants were postmenopausal American women with at least some degree of comorbidity, and mean participant age in most studies was over 60 years. None of the studies focused on perimenopausal women.In relatively healthy postmenopausal women (i.e. generally fit, without overt disease), combined continuous HT increased the risk of a coronary event (after 1 year's use

  10. Evaluation Of Hormone Profile And Dexa Values in Premenopausal, Perimenopausal and Postmenopausal Women

    Directory of Open Access Journals (Sweden)

    Esra Esen

    2005-09-01

    Full Text Available This study was carried out in 130 women, between 44-55 ages, admitted to outpatient clinic of Physical Medicine and Rehabilitation Department of Trakya University Medical Faculty in order to make. comparison of hormone profile and DEXA values of premenopausal, perimenopausal, and postmenopausal women . Three groups were allocated according to climacteric symptoms and menopause condition. Premenopausal group consisted of women who had regular menstruation and did not have any climacteric symptoms , perimenopausal group consisted of women who had menstruation disorder and climacteric symptoms within one year and postmenopausal group consisted of women who had last menstruation within more than one year and less than 5 years. Women who had prior osteoporosis diognosis and treatment, hormone replacement therapy, surgical menopause and menopause duration more than 5 years were excluded from the study. Age, body weight ,height, hormone profile including estradiol (E2, progesterone (P, follicule stimulating hormone (FSH, luteinizing hormone (LH, parathyroid hormone (PTH, thyroid hormones (T3, T4, thyroid stimulating hormone (TSH and DEXA values representing bone mineral density (BMD of both groups were evaluated. In peri and postmenopausal groups, E2, P, FSH and LH values were significantly lower, while there was no significant difference for PTH and thyroid hormone levels comparing to premenopausal group. For DEXA values, T scores of L2-L4, L2, L3, L4, femur neck, trochanter, Wards and Z scores of femur neck, Wards area were significantly lower in peri and postmenopausal groups. It was demonstrated paralel to literature that BMD decreased in peri and early postmenopausal women associated with hormone profile changes, mainly lower E2.

  11. Comparison of biopsychosocial functioning of women of different nationalities in the perimenopausal period

    Directory of Open Access Journals (Sweden)

    Marta Makara-Studzińska

    2014-12-01

    Full Text Available Introduction : The perimenopausal age is a time of many changes in women’s health. Changes in women’s health affect all spheres of life, because health is not merely the absence of disease or infirmity but full psychological, physical and social well-being. Presentation and comparison of the biopsychosocial functioning of women of different races and nationalities in perimenopause, identification of the most common menopause symptoms occurring among women and their needs. Material and methods : Work supported with research examples. Using the PubMed database, the medical literature was searched for works that contain the key words menopause and race or ethnicity published between 1996 and 2013 and available in English. Literature in Polish is a supplementary issue. Results : Various demographic processes taking place in the countries of Africa, North and South America, Asia and Europe are the basis for observing the situation in perimenopausal women in these countries. Caucasian women living in North America and Europe most often experience the negative symptoms of menopause, hindering daily functioning, and women living in urbanized countries in Asia best assess their health condition, both psychosocial and physical. Conclusions : Biopsychosocial functioning of women varies among countries. Developing countries should be given the necessary support and financial information to ensure the health and quality of life in perimenopausal women. In most countries of the world there has been observed the need to promote women’s health, particularly research aimed at prevention, increasing physical activity and attention to nutrition.

  12. Comparative study of climacteric symptoms in perimenopausal and postmenopausal women in Tabriz, Islamic Republic of Iran.

    Science.gov (United States)

    Hakimi, S; Mirghafurvand, M; Seiiedin, S A

    2010-11-01

    The aim of this cross-sectional study was to describe menopausal symptoms in Iranian women in Tabriz, north-west Islamic Republic of Iran. A total of 200 women aged 45-55 years completed a Farsi version of the Greene climacteric scale. The mean total Greene scores for 20 items (1 item was excluded) were 29.34 (SD 9.84) for perimenopausal and 28.14 (SD 10.15)for postmenopausal women. Perimenopausal and postmenopausal women did not differ significantly in any of the subscales or individual items, except on 2 items: "difficulty in sleeping" and "parts of the body feeling numb or tingling". Comparisons with studies in other countries show that women in Tabriz suffer more menopausal symptoms than European woman.

  13. Knowledge, Health Beliefs, and Self-Efficacy regarding Osteoporosis in Perimenopausal Women

    Directory of Open Access Journals (Sweden)

    Renée D. Endicott

    2013-01-01

    Full Text Available The aims of this pilot study were to (1 determine if having a family history of osteoporosis impacts knowledge, health beliefs, and self-efficacy regarding osteoporosis among perimenopausal women aged 42–52 and to (2 describe the impact of an osteoporosis-specific educational intervention had on the knowledge, health beliefs, and self-efficacy of this population. Participants completed three surveys measuring knowledge, health beliefs, and self-efficacy related to osteoporosis before and two months after the educational program. At baseline, no differences were noted in knowledge of osteoporosis among women with and without a family history of osteoporosis, although women with a family history perceived a greater susceptibility for developing osteoporosis than women without the family history. Findings indicate that both groups increased in knowledge of osteoporosis (P<.001. Benefits of calcium increased in the women without a family history of osteoporosis (P<.001 and benefits of exercise increase in women with a family history of osteoporosis (P=.007. There were no significant statistical findings regarding self-efficacy between the two groups of women. Findings indicate that an osteoporosis-specific educational program improves perimenopausal women’s knowledge and some health beliefs.

  14. Treatment of Perimenopausal Syndrome with Ear-Acupressing in Ovariectomied Women

    Institute of Scientific and Technical Information of China (English)

    杨丹; 俞瑾

    2003-01-01

    @@ High follicule-stimulating hormone (FSH), luteinizing hormone (LH) and low estrogen levels that occurred in women in peri-menopausal stage (PMS, including those after ovariectomy and natural menopausal) usually induce a series of clinical symptoms, such as hot flush, sweatiness, insomnia and restlessness. It has been reported that patients without ovulation can be treated by acupuncture through regulating hypothalamic-pituitary-ovarian axis (H-P-O)(1). Could acupuncture also regulate the H-P-O axis in patients with PMS? This study was designed to explore the effects of acupuncture on PMS through applying ear-acupressing (EAP) on women after ovariectomy.

  15. Sweating and thirst perception in premenopausal, perimenopausal and postmenopausal women during moderate exercise

    OpenAIRE

    Emmanuel Amabebe; Sonia I. Omorodion; Janet O. Ozoene; UGWU, ANDREW C.; Leonard F. Obika

    2013-01-01

    Objective: We examined the sweat rate (SR), sweat volume (SV), sweat sodium concentration (S[Na+]) and changes in thirst perception (TP), in premenopausal (preM), perimenopausal (periM) and postmenopausal (postM) women after moderate exercise. Methods: Thirty healthy women comprising preM (22.5 ± 0.8 yrs, n = 10), periM (46.5 ± 1.1 yrs, n = 10) and postM (52.2 ± 0.9 yrs, n = 10) participated in the study. All participants gave informed consent. TP was rated using the visual...

  16. Correlation of bleeding pattern with endometrial histopathologic results in perimenopausal women with abnormal uterine bleeding

    Directory of Open Access Journals (Sweden)

    Zehra Yilmaz

    2015-06-01

    Full Text Available Background: Abnormal Uterine Bleeding (AUB is referred as bleeding outside of normal menstruation pattern and it is the most common gynecological problem for women of all ages. This study was evaluated the correlation of menstrual bleeding patterns and endometrial histopathological findings in perimenopausal women. Methods: This study was done on perimenopausal aged women presented with AUB for the last 6 months at a gynecology clinic of a tertiary medical center. Only the patients with isolated endometrial causes of AUB were selected for study. A total of 313 cases were included in the study. Abnormal bleeding patterns of the patients were recorded and endometrial sampling was performed to all women. AUB was classified as menorrhagia, metrorrhagia, menometrorrhagia, polymenorrhea, intermenstrual bleeding, and histopathological findings were classified as Proliferative Endometrium (PE, Secretory Endometrium (SE, Disordered Proliferative Pattern (DPP, Endometrial Polyp (EP, Chronic Endometritis (CE, Endometrial Hyperplasia (EH, and Endometrial Adenocarcinoma (CA. Results: The most common bleeding pattern was menorrhagia (45.0% and the most common histopathological finding was PE+SE (52.0% in our study. PE+SE and endometrial hyperplasia without atypia were found more common in menorrhagia group. The most histopathological findings were found PE+SE in menometrorrhagia and polymenorrhea group (P 0.05. Conclusions: We concluded that although menometrorrhagia and polymenorrhea were significantly more associated with PE+SE, intermenstrual bleeding was significantly more associated with EP and CE. It is noteworthy that endometrial hyperplasia without atypia is significantly higher in patients with menorrhagia which is the most common abnormal bleeding pattern in perimenopausal aged women. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 547-550

  17. Association between estrogen receptor β gene Rsa1 polymorphism and depressive disorder in peri-menopausal and menopausal women

    Institute of Scientific and Technical Information of China (English)

    YU Xue-wen; REN Yong-hui; LI Xue-cheng; GAO Cheng-ge; LI Fen; HAN Zhen; LI Xu

    2005-01-01

    Objective: To investigate estrogen receptor β (ERβ) gene Rsa1 polymorphism and concentration of estrogen, FSH and LH in serum in peri-menopausal and menopausal women with depressive disorder. Methods: Seventy-four peri-menopausal and menopausal women with depressive disorder met ICD-10 and CCMD-3 assessment criteria for depressive disorder were recruited. ERβ gene Rsa1 polymorphism was analyzed with PCR-RFLP. Serum levels of estrogen, FSH and LH were measured by magnetism-ELISA. Results: The respective frequency of ERβ gene Rsa1 polymorphism was no significant difference between women with depressive disorder and the healthy women (χ2=1.106,P>0.05). The serum level of estrogen was lower in women with depressive disorder than in the healthy women (P<0.05). No difference was found for FSH and LH between two groups. Conclusion: ERβ gene Rsa1 polymorphism may be not associated with depressive disorder in the peri-menopausal and menopausal women. The serum level of estrogen is associated with depressive disorder in the peri-menopausal and menopausal women.

  18. Effect of chemotherapy on sex hormone levels in perimenopause women with breast cancer

    Institute of Scientific and Technical Information of China (English)

    Shang-Jun Liu

    2016-01-01

    Objective:To explore the effect of chemotherapy on the sex hormone levels in perimenopause women with breast cancer.Methods:A total of 90 perimenopause women after breast cancer surgery who were admitted in our hospital from November, 2014 to November, 2015 were included in the study. Those whose PR and ER were positive served as the observation group and were given TAM. Those whose PR and ER were negative served as the control group and were not given TAM. The chemiluminescence method was used to determine the levels of LH, FSH, and E2. The Doppler ultrasound device was used to measure the endometrial thickness and intrauterine depth before and after menopause. After fractional curettage by hysteroscopy, the patients in the observation group were performed with pathological examinations. The pathological change of endometrium before and after menopause was observed.Results:LH and FSH levels in the observation group were significantly lower than those in the control group, while E2 level was significantly higher than that in the control group. The comparison of endometrial thickness and intrauterine depth before and after menopause was not statistically significant. The occurrence rate of endometrial polyps, endometrial carcinoma, simple hyperplasia, and atypical hyperplasia in patients before menopause was significantly less than that in patients after menopause.Conclusions:Due to be in a special endocrine environment, during TAM administration period for perimenopause women with breast cancer, a regular determination of sex hormone levels, adoption of B ultrasound and hysteroscope to detect the endometrial thickness and pathological change are required in order to guide the clinical medication.

  19. A pooled analysis of the efficacy of desvenlafaxine for the treatment of major depressive disorder in perimenopausal and postmenopausal women.

    Science.gov (United States)

    Kornstein, Susan G; Clayton, Anita H; Bao, Weihang; Guico-Pabia, Christine J

    2015-04-01

    Few studies in the literature have examined the efficacy of antidepressant drugs in perimenopausal and postmenopausal women. The objective of the current study was to assess the efficacy of desvenlafaxine (administered as desvenlafaxine succinate) separately in perimenopausal and postmenopausal women with major depressive disorder (MDD). Data were pooled from two double-blind, placebo-controlled clinical trials enrolling perimenopausal and postmenopausal women (40-70 years old) diagnosed with MDD. Patients were randomly assigned to receive desvenlafaxine 100 to 200 mg/day or placebo (8 weeks) or desvenlafaxine 50 mg/day or placebo (10 weeks). The primary efficacy end point for each trial was change from baseline in Hamilton Rating Scale for Depression (HAM-D17) total score at week 8. Secondary end points included change from baseline in Sheehan Disability Scale (SDS) and Menopause Rating Scale (MRS) scores. Changes from baseline in continuous variables were analyzed using analysis of covariance with treatment, region, and baseline in the model. All treatment comparisons were carried out separately in perimenopausal or postmenopausal women, in individual studies, and in the pooled population, adjusting for menopausal status and study. A total of 798 patients were included in the full analysis set (perimenopausal, n=252; postmenopausal, n=546). Desvenlafaxine significantly reduced HAM-D17 total scores versus placebo at week 8 in both perimenopausal (-10.3 vs. -6.5; pdesvenlafaxine versus placebo in perimenopausal (p ≤ 0.024) and postmenopausal women (p ≤ 0.009). A significant treatment by menopausal status interaction was observed for SDS only (p=0.036). Desvenlafaxine demonstrated antidepressant efficacy in both perimenopausal and postmenopausal subgroups of women with MDD. In September 2011, Pfizer received a Complete Response Letter from the United States Food and Drug Administration on its application for approval to market desvenlafaxine for the treatment of

  20. Effects of nutraceuticals on quality of life and sexual function of perimenopausal women.

    Science.gov (United States)

    Caruso, S; Cianci, S; Cariola, M; Fava, V; Rapisarda, A M C; Cianci, A

    2017-01-01

    The aim of the study was to evaluate the effects of nutraceuticals containing Equol, Resveratrol, Quecitine and Passiflora (Zemiar(®), Avantgarde, Pomezia, Rome, Italy) on quality of life (QoL) and sexual function in perimenopausal women. Sixty perimenopausal women having vasomotor symptoms and being in the -1, +1a of the STRAW system (amenorrhea for longer than 60 days and FSH Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) were used to assess QoL, sexual function and sexual distress, respectively. The study had two follow-ups at 3 and 6 months. The women reported an improvement in the KI total score from the baseline (35 ± 4) to the 1st (21 ± 3, p functions (p sexual dysfunction with sexual distress. FSFI and FSDS total scores did not change at the 1st follow-up (p = NS). On the contrary, at the 2nd follow-up, the FSFI score had risen to (27.6 ± 1.5) (p sexual life.

  1. Impact of physical activity and fitness on the level of kinesiophobia in women of perimenopausal age

    Directory of Open Access Journals (Sweden)

    Mariola Saulicz

    2016-07-01

    Full Text Available To determine the impact of physical activity and fitness on the level of physical activity barriers (kinesiophobia in women of perimenopausal age, the study included 105 women between the ages of 48 and 58. A Baecke questionnaire was used to evaluate physical activity and a modified Fullerton test was used to evaluate the fitness level. The level of kinesiophobia was assessed using the Kinesiophobia Causes Scale questionnaire. A low level of habitual physical activity has a negative impact on the values of Biological Domain (r = –0.581, Psychological Domain (r = –0.451, and on the Kinesiophobia Cause Scale total score (r = –0.577. Lower physical activity expressed by a lower score in the Fullerton test also has a negative impact on the level of kinesiophobia. Upper body flexibility (r = –0.434 has the strongest influence on the Biological Domain, whereas upper body strength (r = –0.598 has the greatest impact on the Psychological Domain. A low level of upper body strength also has the greatest impact on the Kinesiophobia Cause Scale total score (r = –0.507. Low levels of physical activity and fitness in women of perimenopausal age favour kinesiophobic attitudes and thereby increase the level of barriers against undertaking physical activity.

  2. Impact of physical activity and fitness on the level of kinesiophobia in women of perimenopausal age

    Directory of Open Access Journals (Sweden)

    Mariola Saulicz

    2016-07-01

    Full Text Available To determine the impact of physical activity and fitness on the level of physical activity barriers (kinesiophobia in women of perimenopausal age, the study included 105 women between the ages of 48 and 58. A Baecke questionnaire was used to evaluate physical activity and a modified Fullerton test was used to evaluate the fitness level. The level of kinesiophobia was assessed using the Kinesiophobia Causes Scale questionnaire. A low level of habitual physical activity has a negative impact on the values of Biological Domain (r = –0.581, Psychological Domain (r = –0.451, and on the Kinesiophobia Cause Scale total score (r = –0.577. Lower physical activity expressed by a lower score in the Fullerton test also has a negative impact on the level of kinesiophobia. Upper body flexibility (r = –0.434 has the strongest influence on the Biological Domain, whereas upper body strength (r = –0.598 has the greatest impact on the Psychological Domain. A low level of upper body strength also has the greatest impact on the Kinesiophobia Cause Scale total score (r = –0.507. Low levels of physical activity and fitness in women of perimenopausal age favour kinesiophobic attitudes and thereby increase the level of barriers against undertaking physical activity.

  3. Health of Indonesian women city-dwellers of perimenopausal age.

    Science.gov (United States)

    Samil, R S; Wishnuwardhani, S D

    1994-10-01

    In the last few years more women of climacteric age, living in urban areas, have been seeking medical care. In 1989, on the invitation of 6 women's organizations in Jakarta and other cities, the Indonesian Menopause Society gave talks and held discussions in cooperation with the Department of Obstetrics and Gynaecology, Faculty of Medicine of the University of Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta. These occasions were used to accumulate data from women participants of 40 years of age and older. The age of the respondents ranged between 40-59 years. Most were 42 years old (13.9%). Ninety-four percent were still married. Twenty-five percent had three living children. Sixty-three percent of the respondents were high school graduates who worked full time (33%), part time, or were unemployed. The average menarche age was 13 and menopausal age 50-51. Menopausal complaints were rare, hence medical consultations were rare. Tranquilizers were prescribed for those who did seek medical help. This data constitutes the basis of the formulation of a strategy to solve menopause related problems in Indonesia, where female life expectancy, and the contribution of women to society, is on the increase.

  4. [Contraception in perimenopause].

    Science.gov (United States)

    Merki-Feld, G S

    2000-10-01

    Perimenopausal women are still potentially fertile and pregnancy is attended with increased maternal and perinatal mortality. Several contraceptive methods can be used therapeutic for the treatment of climacteric symptoms like menstrual irregularities, flushes and vaginal dryness. Low-dose oral contraceptives (OC) prevent climacteric symptoms and additionally protect from perimenopausal bone loss. However, the individual cardiovascular risk increases with age and is even higher in perimenopausal women using OCs. Therefore for women with cardiovascular risk factors sterilization, barrier methods, progestin-only methods and intrauterine devices (IUD) are the better choice. Prolonged and heavy menses can be treated with the levonorgestrel-releasing IUD or injectable progestogens. If estrogen replacement is necessary, a low-dose treatment with natural estrogens can be combined with barrier methods, the levonorgestrel-releasing IUD and injectable progestogens. The variety of contraceptive options available to perimenopausal women allows individual counseling and thus may enhance compliance.

  5. Educational intervention on cardiovascular parameters in perimenopausal women with a cardiovascular risk factor. Randomised clinical trial.

    Science.gov (United States)

    Soto Rodríguez, Anxela; García Soidán, José Luís; Arias Gómez, María Jesús; Del Álamo Alonso, Alberto; Leirós Rodríguez, Raquel; Pérez Fernández, María Reyes

    2017-07-22

    Randomised clinical trial performed in two urban health centres in Spain. To evaluate if educational intervention in women of perimenopausal age with hypertension, diabetes mellitus and/or dyslipidaemia could achieve significant changes in the reduction of biochemical and haemodynamic risk parameters. The study included 320 women aged between 45 and 60 years old who were diagnosed with hypertension, diabetes mellitus and/or dyslipidaemia. They were randomly assigned to the experimental group (n=160) and the control group (n=160). The intervention group received three educational sessions and the control group received an informative leaflet sent by mail. Haemodynamic and biochemical variables were evaluated at baseline and one year later in both groups. Women in the intervention group showed a decrease in low density lipoprotein (P=.034), (-5.89±29.8; 95% CI: -13.1/0.27) and an increase in high density lipoprotein (P=.013), (2.71±10.6; 95% CI: -1.36/6.20), as well as improvements in systolic blood pressure (P=.016), (-2.16±11.8; 95% CI: -4.4/0.01) and frequency (P=.003), (-1.46±10.3; 95% CI: -3.34/0.42) compared to women in the control group. Women in the control group significantly increased glucose (P=.04), (4.84±15.5; 95% CI: -0.75/31.3) and gamma-glutamyltranspeptidase (P=.031), (3.61±14.7; 95% CI: 0.87/6.36) levels more than those in the experimental group. An educational intervention can be an effective method of reducing the parameters associated with an increased likelihood of cardiovascular disease in women at perimenopausal age with hypertension, diabetes mellitus and/or dyslipidaemia. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  6. Effects of tai chi exercise on bone health in perimenopausal and postmenopausal women: a systematic review and meta-analysis.

    Science.gov (United States)

    Sun, Z; Chen, H; Berger, M R; Zhang, L; Guo, H; Huang, Y

    2016-10-01

    Tai chi exercise may have positive effects on bone health in perimenopausal and postmenopausal women. This systematic review is the first to summarize evidence to clarify the efficacy of tai chi exercise in bone health. The benefits of tai chi exercise on bone health remain unclear; further studies are needed. Emerging randomized controlled trials (RCTs) exploring the efficacy of tai chi exercise on bone health among older women, but yielded inconclusive results. Our objective is to conduct a systematic review to evaluate evidence from RCTs to clarify the efficacy of tai chi exercise on bone mineral density (BMD), and bone turnover markers (BTM) in perimenopausal and postmenopausal women. Six electronic databases were searched, and reference lists of systematic reviews and identified studies from the search strategy were also screened. We included all RCTs that investigate tai chi exercise for bone health in perimenopausal and postmenopausal women. Data selection, extraction, and evaluation of risk of bias were performed independently by two reviewers. Ten trials detailed in 11 articles were included. Six of the 11 studies reported positive outcomes on bone health. Results of our meta-analysis showed a significant effect of tai chi exercise on BMD change at the spine compared with no treatment in perimenopausal and postmenopausal women. When tai chi exercise combined with a calcium supplement was compared with the calcium supplement alone, the result of BMD change at the spine showed no significant effect. Because the measurable effect observed was minimal, and due to the low quality of methodology of the studies, we conclude that the result is of limited reliability. Tai chi exercise may have benefits on bone health in perimenopausal and postmenopausal women, but the evidence is sometimes weak, poor, and inconsistent. Consequently, only limited conclusions can be drawn regarding the efficacy of tai chi exercise on bone health. Further well designed studies with

  7. Phytoestrogen-Rich Natural Preparation for Treatment of Climacteric Syndrome and Atherosclerosis Prevention in Perimenopausal Women.

    Science.gov (United States)

    Kirichenko, T V; Myasoedova, V A; Orekhova, V A; Ravani, A L; Nikitina, N A; Grechko, A V; Sobenin, I A; Orekhov, A N

    2017-08-01

    The present study evaluated the risks and benefits of phytoestrogen treatment in healthy perimenopausal women in relation to the dynamics of climacteric syndrome and progression of atherosclerosis. Study participants were treated with placebo or phytoestrogen-rich natural preparation Karinat based on grape (Vitis vinifera) seeds, green tea (Camellia sinensis) leaves, hop (Hunulus lupulus) cone powder and garlic (Allium sativum) powder. The dynamics of climacteric syndrome was evaluated by Kupperman Index and Utian Quality of Life Scale. Atherosclerosis progression was evaluated by measuring carotid intima-media thickness. Significant changes of climacteric syndrome's severity in both Karinat and placebo groups (p = 0.005 and p = 0.001) were obtained after 24 months of follow-up. Detailed analysis of Kupperman Index suggested that Karinat possessed a significant effect on nervousness (p = 0.010), weakness (p = 0.020) and formication (p = 0.010). A significant improvement of medical (p = 0.070) and emotional (p = 0.060) components of Kupperman Index and Utian Quality of Life Scale was also observed in Karinat group. However, difference in carotid intima-media thickness between the two groups was not statistically significant at follow-up. A slight positive effect of phytoestrogens on climacteric syndrome manifestations was demonstrated in this study. Karinat can be used for alleviation of climacteric syndrome and cardiovascular disease prevention in perimenopausal women. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Prevalence and risk factors of depressive symptoms in perimenopausal and early postmenopausal women at a gynecological clinic in Shanghai%上海某妇科门诊围绝经期及绝经后期妇女抑郁症状检出率及相关因素

    Institute of Scientific and Technical Information of China (English)

    陶晶; 仇剑崟; 顾红亮; 杨慧琳; 陈静; 王祖承

    2011-01-01

    Background: Hormonal fluctuations during the perimenopausal period are often associated with both physical and psychological symptoms so women are at high risk of depression during this period. However, the complex interaction of biopsychosociul factors in the development of depression during the menopause are not, as yet, fully known.Objective: Assess the prevalence of depressive symptoms and the risk factors for depressive symptoms in perimenopausal and early postmenopausal women in Shanghai, China.Methods: 287 perimenopausal and early postmenopausal women 45-55 years of age were randomly selected from a gynecological clinic at a women's hospital in Shanghai. Respondents completed three questionnaires: a demographic profile questionnaire, Beck's Depression Inventory (BDI), and the Kupperman Menopausal Index(KMI).Results: The most frequent menopausal symptoms reported in the KMI by these respondents were hot flashes ( 84.0% ), arthralgia and myalgia ( 83.3% ), fatigue ( 81.5% ) and palpitations ( 74.9% ). Using the cutoff score of 5 on the BDI, 104 of the subjects ( 36.2%;95% CI = 30.6%- 41.8% )had clinically significant depressive symptoms. Compared to those without significant depressive symptoms,those with depressive symptoms were significantly less likely to have had breast-feed their children; more likely to have a family history of menopausal symptoms; more likely to be unmarried, divorced or widowed; and had a smaller mean household living space. After excluding the 4 items about depression, the mean(SD) adjusted total score of the 7 remaining items on the KMI was significantly higher in the depressed group [ 14.7( 6. 5) vs 11.6 (5.5); t = 4.11, P < 0. 001 ]. Four factors remained independently related to having clinically significant depressive symptom in the logistic regression analysis: family history of menopausal symptoms ( OR = 2.43, 95% CI = 1.15-5.12), high adjusted total KMI score (2.79, 1.49-5.26), no prior breastfeeding (2

  9. [Clinical trial with educational intervention in perimenopausal women with cardiovascular risk factor].

    Science.gov (United States)

    Soto-Rodríguez, Anxela; García-Soidán, José Luís; de Toro-Santos, Manuel; Rodríguez-González, Manuel; Arias-Gómez, M Jesús; Pérez-Fernández, María Reyes

    To assess whether an educational intervention in women in perimenopausal age with diabetes mellitus, hypertension and/or dyslipidemia could improve aspects of quality of life and exercise. A randomized clinical trial. physical activity, quality of life and weight in women aged 45-60 years (n = 320) at time 0 and 12 months after surgery. intervention group (IG): 3 interactive workshops on cardiovascular disease prevention and control group (CG): information by mail. The IG obtained better scores on the mental component of quality of life one year later (p < 0.05) and showed a significant increase in physical activity (p < 0.01). GI women maintained their weight while in CG women it increased (p < 0.01). A simple educational intervention in premenopausal women with a cardiovascular risk factor improves aspects of quality of life and of healthy habits such as physical activity. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  10. Adherence to Mediterranean dietary pattern and menopausal symptoms in relation to overweight/obesity in Spanish perimenopausal and postmenopausal women.

    Science.gov (United States)

    Sayón-Orea, Carmen; Santiago, Susana; Cuervo, Marta; Martínez-González, Miguel A; Garcia, Aquilino; Martínez, Jose Alfredo

    2015-07-01

    This study aims to assess the relationship of adherence to the Mediterranean dietary pattern, as well as the presence of menopausal symptoms, with overweight/obesity in Spanish perimenopausal and postmenopausal women. Participants in this cross-sectional study were 8,954 Spanish perimenopausal or postmenopausal women. Anthropometric measurements were recorded, and all women were interviewed to assess their adherence to the Mediterranean dietary pattern, using a validated questionnaire and the Menopause and Health subscale of the validated Cervantes Scale. A logistic regression model was used to investigate the association between categories of adherence to the Mediterranean diet and the odds of being overweight/obese. Multinomial logistic regression was used to study the association between menopausal symptoms and the odds of being overweight/obese (reference categories: participants in the low-adherence category and participants with no menopausal problems). After adjustment for relevant confounders, the odds ratio (95% CI) for being overweight/obese among women in the highest category of adherence to the Mediterranean dietary pattern was 0.68 (0.60-0.78; P for trend obese was 3.05 (1.98-4.71) for the category "severe problems" in comparison with the category "no problems." Higher adherence to a healthy dietary pattern (Mediterranean diet) is inversely associated with overweight/obesity in perimenopausal and postmenopausal women. The occurrence of low to severe problems during perimenopause or postmenopause is positively associated with overweight/obesity. Therefore, high adherence to the Mediterranean dietary pattern and a body mass index of 25kg/m(2) or lower might improve quality of life in women at these stages.

  11. Comparative Assessment of the Effects of Hatha Yoga and Physical Exercise on Biochemical Functions in Perimenopausal Women

    Science.gov (United States)

    Nayak, Gayathry; Nayak, Akshatha Ganesh; Rao, Anjali

    2016-01-01

    Introduction Menopause is a transitional phase in which some women experience discomfort, while others may exhibit variety of symptoms. The power of yoga therapy in relieving stress, enhancing health, improving fitness and managing symptoms of a variety of disorders is remarkable. Aim The current study was designed to study the effect of Hatha yoga therapy and regular physical exercise on the Fasting Blood Sugar (FBS), Glycated Haemoglobin (GHB), Thyroid Stimulating Hormone (TSH), serum cortisol and total plasma thiol levels in perimenopausal women. Materials and Methods The study included 216 women with perimenopausal symptoms, 111 in test group (Hatha yoga) and 105 in control group (physical exercise). The duration of intervention was 45 minutes every day for 12 weeks. Blood samples were collected in the pre and post intervention period. Statistical significance was defined as p<0.05. Results FBS and GHB (p≤0.05) showed a significant decrease after yoga therapy. Cortisol levels significantly (p≤0.05) increased in the post intervention period in the control group. However, it is maintained in the test group between the two time periods. The total plasma thiols level showed a rise in the post intervention period, significant rise (p≤0.001) in control group but not significant in the test group. The TSH levels were not altered in any group. Conclusion It is concluded that exercise helps in maintaining the sugar levels but calming effects of yoga practice is important in relieving stress and enhancing health in perimenopausal women. PMID:27656468

  12. Comparative Assessment of the Effects of Hatha Yoga and Physical Exercise on Biochemical Functions in Perimenopausal Women.

    Science.gov (United States)

    Chaturvedi, Abhishek; Nayak, Gayathry; Nayak, Akshatha Ganesh; Rao, Anjali

    2016-08-01

    Menopause is a transitional phase in which some women experience discomfort, while others may exhibit variety of symptoms. The power of yoga therapy in relieving stress, enhancing health, improving fitness and managing symptoms of a variety of disorders is remarkable. The current study was designed to study the effect of Hatha yoga therapy and regular physical exercise on the Fasting Blood Sugar (FBS), Glycated Haemoglobin (GHB), Thyroid Stimulating Hormone (TSH), serum cortisol and total plasma thiol levels in perimenopausal women. The study included 216 women with perimenopausal symptoms, 111 in test group (Hatha yoga) and 105 in control group (physical exercise). The duration of intervention was 45 minutes every day for 12 weeks. Blood samples were collected in the pre and post intervention period. Statistical significance was defined as pyoga therapy. Cortisol levels significantly (p≤0.05) increased in the post intervention period in the control group. However, it is maintained in the test group between the two time periods. The total plasma thiols level showed a rise in the post intervention period, significant rise (p≤0.001) in control group but not significant in the test group. The TSH levels were not altered in any group. It is concluded that exercise helps in maintaining the sugar levels but calming effects of yoga practice is important in relieving stress and enhancing health in perimenopausal women.

  13. No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women

    DEFF Research Database (Denmark)

    Rejnmark, L; Vestergaard, P; Charles, P

    2006-01-01

    INTRODUCTION: Vitamin K functions as a co-factor in the post-translational carboxylation of several bone proteins, including osteocalcin. AIM: The aim of this study was to investigate the relationship between vitamin K(1) intake and bone mineral density (BMD) and fracture risk in a perimenopausal...... Danish population. DESIGN: The study was performed within the Danish Osteoporosis Prevention Study (DOPS), including a population-based cohort of 2,016 perimenopausal women. During the study approximately 50% of the women received hormone replacement therapy (HRT). Associations between vitamin K(1......) intake and BMD were assessed at baseline and after 5-years of follow-up (cross-sectional design). Moreover, associations between vitamin K(1) intake and 5-year and 10-year changes in BMD were studied (follow-up design). Finally, fracture risk was assessed in relation to vitamin K(1) intake (nested case...

  14. [Effect of treatment with diet on reducing levels of sex hormones in perimenopausal women with overweight and obesity].

    Science.gov (United States)

    Łokieć, Katarzyna; Błońska, Aleksandra; Walecka-Kapica, Ewa; Stec-Michalska, Krystyna

    2016-06-01

    Nowadays, fight against obesity is a big challenge for the developed countries. Perimenopausal women are especially prone to becoming overweight and obese. This is due to changes in hormone levels and alterations in the sex hormones synthesis pathway. The aim of this study was to evaluate the levels of sex hormones in overweight and obese women during menopause following the three month period of reducing diet. The study involved women aged 55±4,75 years. Group I - 33 overweight women (BMI 28,06±1,00 kg/m(2)). Group II - 32 obese women (BMI 34,22±3,79 kg/m(2)). Anthropometric measurements, body composition tested with Bodystat QuadScan 4000 analyzer and levels of sex hormones in the blood was determined before and after the three-months of reducing diet in both groups. Statistical data analysis was performed. After three-months of reducing diet it was noticed that levels of BMI, body fat, FSH, DHEA-S and androstenedione were decreased in a statistically significant manner. A significant increase in estradiol levels after reduction of visceral adipose tissue in both groups, overweight and obese women, was observed. However, only in the group of obese women, a decrease in BMI correlated with a significant increase in estradiol levels. Application of appropriate reducing diet in perimenopausal overweight and obese women has positive impact on visceral adipose tissue distribution and causes an increase in sex hormones levels. Perimenopausal overweight and obese women should pursue weight reduction to improve their chances of contracting cardiovascular diseases. © 2016 MEDPRESS.

  15. Effect of fat mass and lean mass on bone mineral density in postmenopausal and perimenopausal Thai women

    Directory of Open Access Journals (Sweden)

    Namwongprom S

    2013-02-01

    Full Text Available Sirianong Namwongprom,1 Sattaya Rojanasthien,2 Ampica Mangklabruks,3 Supasil Soontrapa,4 Chanpen Wongboontan,5 Boonsong Ongphiphadhanakul61Clinical Epidemiology Program and Department of Radiology, 2Department of Orthopaedics, 3Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 4Department of Orthopaedics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 5Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 6Department of Internal Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandBackground: The purpose of this study was to investigate the association between fat mass, lean mass, and bone mineral density (BMD in postmenopausal and perimenopausal Thai women.Methods: A cross-sectional study was conducted in 1579 healthy Thai women aged 40–90 years. Total body, lumbar spine, total femur, and femoral neck BMD and body composition were measured by dual x-ray absorptiometry. To evaluate the associations between fat mass and lean mass and various measures of BMD, multivariable linear regression models were used to estimate the regression coefficients for fat mass and lean mass, first in separate equations and then with both fat mass and lean mass in the same equation.Results: Among the study population, 1448 subjects (91.7% were postmenopausal and 131 (8.3% were perimenopausal. In postmenopausal women, after controlling for age, height, and duration of menopause, both fat mass and lean mass were positively correlated with BMD when they were analyzed independently of each other. When included in the same equation, both fat mass and lean mass continued to show a positive effect, but lean mass had a significantly greater impact on BMD than fat mass at all regions except for total body. Lean mass but not fat mass had a positive effect on BMD at all skeletal sites except the lumbar spine, after controlling for age and height in perimenopausal

  16. Burning mouth syndrome – a common dental problem in perimenopausal women

    Directory of Open Access Journals (Sweden)

    Zuzanna Ślebioda

    2014-06-01

    Full Text Available Burning mouth syndrome (BMS is characterized by the presence of burning, paresthesia or pain of the oral mucosa in the absence of pathologic lesions revealed during the clinical examination [1-3]. Moreover, the pain may be accompanied by oral dryness, hypersensitivity to some food compounds and taste disorders [4-6]. Etiopathogenesis of this condition remains unclear. Potential local causative factors include among the others mechanical irritation, parafunctions and dysfunctions of the stomatognathic system, contact allergy to dental materials and electro-galvanic phenomena. Potential systemic causes include diabetes mellitus, B group vitamin deficiency (vitamins B1, B2, B6 and B12, folic acid and iron deficiency, hormonal imbalance, gastrointestinal diseases, psychiatric and neurological disorders and drug-induced side effects. The hypothesis concerning the role of hormonal changes in the development of BMS seems to be confirmed by a high incidence of this condition in perimenopausal women [2, 7, 8]. Up to now, due to an unclear etiology of the disease, the treatment is very often ineffective and mainly symptomatic, which may exacerbate patient’s anxiety and discomfort. In this paper we present the main etiologic factors of the burning mouth syndrome. We discuss the basic diagnostic and therapeutic methods and the influence of hormonal replacement therapy on the course of BMS based on the current medical reports.

  17. Perimenopausal women with Hashimoto's thyroiditis%女性围绝经期与桥本氏甲状腺炎

    Institute of Scientific and Technical Information of China (English)

    王萍

    2015-01-01

    Analysis the perimenopausal women occurred in Hashimoto's thyroiditis. Results show that around menopause and Hashimoto's thyroiditis has an important relationship, for peri menopausal women need to focus on Hashimoto's thyroiditis.%分析目前女性围绝经期发生桥本氏甲状腺炎的原因.结果可知围绝经期和桥本氏甲状腺炎有着重要关系,对于围绝经期女性需要着重关注桥本氏甲状腺炎.

  18. Does levonorgestrel-releasing intrauterine system increase breast cancer risk in peri-menopausal women? An HMO perspective.

    Science.gov (United States)

    Siegelmann-Danieli, Nava; Katzir, Itzhak; Landes, Janet Vesterman; Segal, Yaakov; Bachar, Rachel; Rabinovich, Hadas Rotem; Bialik, Martin; Azuri, Joseph; Porath, Avi; Lomnicky, Yossef

    2017-09-14

    To evaluate the association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer (BC) risk. A cohort of all Maccabi Healthcare Services (MHS) female members aged 40-50 years between 1/2003 and 12/2013 was used to identify LNG-IUS users as "cases," and 2 age-matched non-users as "controls." Exclusion criteria included: prior BC diagnosis, prior (5 years pre-study) and subsequent treatment with other female hormones or prophylactic tamoxifen. Invasive tumors were characterized by treatments received (chemotherapy, hormonal therapy, trastuzumab, or combination thereof). The analysis included 13,354 LNG-IUS users and 27,324 controls (mean age: 44.1 ± 2.6 vs. 44.9 ± 2.8 years; p < 0.0001). No significant differences in 5-year Kaplan-Meier (KM) estimates for overall BC risk or ductal carcinoma in situ occurrence were observed between groups. There was a trend towards higher risk for invasive BC in LNG-IUS users (5-year KM-estimate: 1.06% vs. 0.93%; p = 0.051). This difference stemmed primarily from the younger women (40-45 years; 0.88% vs. 0.69%, p = 0.014), whereas in older women (46-50 years), it was non-significant (1.44% vs. 1.21%; p = 0.26). Characterization of invasive BC by treatment demonstrated that LNG-IUS users had similar proportions of tumors treated with hormonal therapy, less tumors treated with trastuzumab, (7.5% vs. 14.5%) and more tumors treated with chemotherapy alone (25.8% vs. 14.9%; p = 0.041). In peri-menopausal women, LNG-IUS was not associated with an increased total risk of BC, although in the subgroup of women in their early 40's, it was associated with a slightly increased risk for invasive tumors.

  19. Efficacy and safety of desvenlafaxine 50 mg/d in a randomized, placebo-controlled study of perimenopausal and postmenopausal women with major depressive disorder.

    Science.gov (United States)

    Clayton, Anita H; Kornstein, Susan G; Dunlop, Boadie W; Focht, Kristen; Musgnung, Jeff; Ramey, Tanya; Bao, Weihang; Ninan, Philip T

    2013-10-01

    Evaluate the 8-week efficacy and safety of desvenlafaxine at the recommended dose of 50 mg/d in perimenopausal and postmenopausal women with major depressive disorder (MDD) based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. This phase 4, multicenter, parallel-group, randomized, double-blind, placebo-controlled study was conducted from June 30, 2010, to June 8, 2011. Patients received placebo or desvenlafaxine 50 mg/d (1:1 ratio; n = 217 in each group). The primary outcome measure was the change at week 8 in the 17-item Hamilton Depression Rating Scale (HDRS17) total score. Secondary outcome measures included change in the Sheehan Disability Scale (SDS), the Clinical Global Impressions-Improvement scale (CGI-I), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Visual Analog Scale-Pain Intensity (VAS-PI). At end point, compared to placebo, desvenlafaxine was associated with a significantly greater decrease in HDRS17 total scores (last-observation-carried-forward analysis; adjusted mean change from baseline -9.9 vs -8.1, respectively; P = .004) and significant improvements on the CGI-I (P Desvenlafaxine was generally safe and well tolerated. Short-term treatment with desvenlafaxine 50 mg/d was effective for the treatment of MDD in perimenopausal and postmenopausal women, with significant benefits on pain and functional outcomes evident as early as week 2. The safety and tolerability of desvenlafaxine were consistent with data in other populations. ClinicalTrials.gov identifier: NCT01121484. © Copyright 2013 Physicians Postgraduate Press, Inc.

  20. ABNORMAL UTERINE BLEEDING IN PERIMENOPAUSE

    Directory of Open Access Journals (Sweden)

    Shivaji

    2016-06-01

    Full Text Available BACKGROUND In the peri-menopausal and post-menopausal women, 70% of the gynaecological problems are due to AUB. In the United States, 11% of the hysterectomies are performed for AUB per year. During climacteric, ovarian activity declines leading to anovulation or irregular maturation of follicles. Therefore, the menstrual cycles are often anovulatory and irregular leading to AUB. Prolonged anovulatory periods with unopposed oestrogen stimulation lead to endometrial hyperplasia. This increases the risk of endometrial cancers. Over a decade the progression of endometrial hyperplasia to carcinoma is as follows: Simple hyperplasia - 1%, Complex hyperplasia - 3%, Simple hyperplasia with atypia - 8% and Complex hyperplasia with atypia 29% [Jeffcoate]. AIMS The objective of this study is to correlate the symptoms and the various menstrual patterns to the histopathological diagnosis, so that this knowledge can be applied for an early evaluation and diagnosis of the complications of AUB, and thus arrive at a timely and effective therapeutic strategies. METHODS This is a retrospective study of 314 patients of peri-menopausal age group presenting with AUB in the Department of Gynaecology at SVMCH and RC, Ariyur, Pondicherry, between 2011 and 2014. The study sample consisted of 314 samples of endometrium obtained by dilation and curettage as a day care procedure. RESULTS Menorrhagia is the predominant symptom, 128 cases [40.8%] and was associated with proliferative, secretory and hyperplastic endometrium. Metrorrhagia cases were 53 [16.9%], which predominantly showed secretory followed by proliferative histological pattern. There were 4 cases of Endometrial carcinoma [1.27%]. Simple hyperplasia with atypia were 10 cases [3.29%] and Complex hyperplasia with atypia cases were 7 [2.33%]. CONCLUSION AUB in perimenopausal period is very significant, as it accounts for about 70% of all gynaecologic outpatients. Endometrial hyperplasia is a precursor of

  1. 围绝经期妇女焦虑症心理治疗研究进展%Research progress of the psychological treatment of the anxiety disorders of the women in the peri-menopausal period

    Institute of Scientific and Technical Information of China (English)

    张莉; 王彩霞; 李萍

    2016-01-01

    Along with the social competition increasingly serious, the women bear more and more physical, psychological, and social pressures so as to cause some women to advance into the peri-menopausal period early, and appear the more serious peri-menopausal anxiety disorder. The prevalence of the peri-menopausal anxiety disorder is high, the rates of the diagnosis and treatment are low and it is more easily misdiagnosed as the organic disease, which seriously affects the family life and work quality of the women. Therefore, development of the community psychological treatment, active cooperation with the district mental health center and formation of a mental disease prevention and control network can improve the social function of the women in the peri-menopausal period better, promote the community women’s health and the rapid development of the community psychological treatment of the peri-menopausal anxiety disorder.%随着社会竞争日益激烈,妇女承受的生理、心理、社会压力越来越大,致使部分女性提早进入围绝经期,出现较为严重的围绝经期焦虑症。围绝经期焦虑症患病率较高,诊断率和治疗率均很低,临床更易误诊为器质性疾病,严重影响妇女的家庭生活和工作。因此,大力发展社区心理治疗,主动与区精神卫生中心合作,形成心理疾病防控网络,可更好地提高妇女在围绝经期的社会功能,促进社区妇女健康,推动社区围绝经期焦虑症心理治疗的迅速发展。

  2. Short-term efficacy and safety of desvenlafaxine in a randomized, placebo-controlled study of perimenopausal and postmenopausal women with major depressive disorder.

    Science.gov (United States)

    Kornstein, Susan G; Jiang, Qin; Reddy, Sujana; Musgnung, Jeff J; Guico-Pabia, Christine J

    2010-08-01

    The risk for major depressive disorder (MDD) increases during the menopausal transition. Nonetheless, no large, placebo-controlled studies have prospectively assessed the efficacy of antidepressants in perimenopausal or postmenopausal women. This randomized, double-blind, placebo-controlled trial evaluated the short-term efficacy and safety of desvenlafaxine (administered as desvenlafaxine succinate) in perimenopausal and postmenopausal women with DSM-IV-defined MDD. 387 depressed perimenopausal and postmenopausal women aged 40 to 70 years were randomly assigned to placebo or desvenlafaxine (100 or 200 mg/d at the discretion of the investigator) in an 8-week, flexible-dose trial conducted from September 2006 to June 2008. The primary efficacy variable was change from baseline in 17-item Hamilton Depression Rating Scale (HDRS(17)) total score, analyzed using a mixed-effects model for repeated-measures analysis. Safety data were collected throughout the trial. The reduction in adjusted HDRS17 total scores from baseline to week 8 (mean daily dose after titration, 162 to 176 mg/d) was significantly greater for desvenlafaxine (-12.64) compared with placebo (-8.33; P desvenlafaxine treatment (perimenopausal, P = .003; postmenopausal, P desvenlafaxine compared with placebo (31.6% [P desvenlafaxine-treated patients and 4/125 (3.2%) placebo-treated patients discontinued due to adverse events. Treatment-emergent adverse events were reported by 94/125 (75.2%) placebo-treated patients and 218/256 (85.2%) desvenlafaxine-treated patients. Short-term treatment with desvenlafaxine was effective and generally well tolerated in perimenopausal and postmenopausal women with MDD. clinicaltrials.gov Identifier: NCT00369343. Copyright 2010 Physicians Postgraduate Press, Inc.

  3. Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: a novel role of Nigella sativa.

    Science.gov (United States)

    Latiff, Latiffah Abdul; Parhizkar, Saadat; Dollah, Mohammad Aziz; Hassan, Syed Tajuddin Syed

    2014-12-01

    The aim of this open label crossover study was to investigate the effects of Nigella sativa on reproductive health and metabolic profile of perimenopausal women in Rawang, Malaysia. Sixty nine perimenopausal women aged 45 to 65 were allocated into the experimental group treated orally with 1600mg/day of encapsulated pure powdered N. sativa compared to control groups treated with placebo for 12 weeks. At the end of study, participants underwent washout period for fourteen days before being crossed over and continued for another cycle of treatment. Participants were abstained from taking any other drugs, herbal preparations or food supplements throughout the study. Body weight, height, waist circumference, blood pressure, biochemical parameters and hormonal levels were measured at baseline and at the end of experiment for both cycles. Face to face interview was carried out at baseline and every week to check for compliance, minimize dropouts and to record reproductive health and quality of life indicators using Greene climacteric and SF-36 instruments. The treatment groups in both cycles showed significant improvement with reference to low density lipoprotein cholesterol and blood glucose (P<0.05). There were no significant differences between groups in total cholesterol, high density lipoprotein and triglyceride concentration. Treatment with N. sativa induced a significant reduction of prevalence and severity of menopausal symptomsas well as significant improvement in some components of quality of life (P<0.05). These results suggested that treatment with N. sativa exert a therapeutic and protective effect by modifying weight gain, improving lipid profile and blood glucose as well as hormonal level which is believed to play an important role in the pathogenesis of metabolic syndrome during menopause.

  4. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life.

    Science.gov (United States)

    Barnhart, K T; Freeman, E; Grisso, J A; Rader, D J; Sammel, M; Kapoor, S; Nestler, J E

    1999-11-01

    Dehydroepiandrosterone (DHEA), an androgenic steroid hormone, exhibits an age-related decline. Perimenopausal women have only approximately 50% of peak DHEA levels. Despite limited scientific data, DHEA has gained recognition as a dietary supplement to reduce the symptoms of aging and improve well-being. This randomized, double-blind placebo-controlled trial examined the effects of 50 mg/day of oral DHEA supplementation, for 3 months, on 60 perimenopausal women with complaints of altered mood and well-being. Changes in the serum endocrine profile of women in the DHEA group were significantly greater than the placebo group, including a 242% [95% confidence interval (CI) +60.1, +423.9] increase in DHEAS, a 94.8% (95% CI +34.2, +155.4) increase in testosterone, and a 13.2% (95% CI -27.88, +0.5) decline in cortisol compared to baseline. Women receiving DHEA had a 10.1% (95% CI -15.0, -5.1) decline in high-density lipoprotein and an 18.1% (95% CI -32.2, -3.9) decline in Lp(a) from baseline, but these declines did not significantly differ from women who received placebo. Women receiving DHEA did not have any improvements significantly greater than placebo in the severity of perimenopausal symptoms, mood, dysphoria, libido, cognition, memory, or well-being. DHEA supplementation significantly effects the endocrine profile, may affect the lipid profile, but does not improve perimenopausal symptoms or well-being compared to placebo.

  5. [Analysis of relationships between perimenopausal symptoms and professional functioning and life satisfaction--Subjective perception of the dependence in women aged 40+].

    Science.gov (United States)

    Nowakowska, Iwona; Rasińska, Renata; Głowacka, Maria Danuta

    2015-01-01

    The aim of the study was to analyse and present the opinions of women in perimenopause on subjectively perceived symptoms characteristic of the climacteric period, and connected with their professional functioning, as well as to evaluate the effects of selected variables on the incidence and severity of these symptoms and the women's life satisfaction. The study included 250 professionally active women in perimenopausal age (40-57 years). The study used the Satisfaction with Life Scale (SWLS) to evaluate life satisfaction of women and the Kupperman Index (KI) as quantitative and qualitative self-assessment of climacteric symptoms. The authors also used a questionnaire of their own design that contains an index of defined symptoms of perimenopause, which warrants the use of Pareto-Lorenz analysis. The obtained results prove the presence of statistically significant correlations between the occurrence and severity of menopausal symptoms and the place of enployment (p=0.04912), gynecological care (p=0.00325), hormone replacement therapy (HRT) (p=0.01523) and assessment of life satisfaction (p=0.0325). Among the symptoms particularly influencing effective professional functioning, women pointed out hot flashes, irritability, reduced concentration and coordination, sleep disturbances, and increased sweating. There is a statistically significant correlation between the woman's place of employment, gynecological care, HRT, the evaluation of life satisfaction and the severity of perimenopausal symptoms. A set of symptoms whose presence and severity influence the sense of life satisfaction and evaluation of professional functioning was observed. Among the most frequently reported symptoms that exert an adverse effect on professional functioning of women are: hot flushes, irritability, reduced concentration and coordination, sleep disturbances, and increased sweating. This work is available in Open Access model and licensed under a CC BY-NC 3.0 PL license.

  6. Post hoc analysis of the efficacy and safety of desvenlafaxine 50 mg/day in a randomized, placebo-controlled study of perimenopausal and postmenopausal women with major depressive disorder.

    Science.gov (United States)

    Kornstein, Susan G; Clayton, Anita; Bao, Weihang; Guico-Pabia, Christine J

    2014-08-01

    This post hoc analysis assessed the efficacy of desvenlafaxine 50 mg/day for treating major depressive disorder in perimenopausal versus postmenopausal women enrolled in a 10-week, double-blind, placebo-controlled study. Perimenopausal and postmenopausal women (40-70 y) diagnosed with major depressive disorder were randomly assigned to receive desvenlafaxine 50 mg/day or placebo. Changes from baseline in the primary efficacy variable (17-item Hamilton Rating Scale for Depression [HAM-D17] score, week 8) and in other secondary efficacy variables (Sheehan Disability Scale and Menopause Rating Scale) were analyzed using analysis of covariance with treatment, region, and baseline in the model. Clinical Global Impressions-Improvement Scale was analyzed with the Cochran-Mantel-Haenszel test. Response and remission rates were evaluated using logistic regression with treatment, region, and baseline HAM-D17 in the model. Of 426 women (desvenlafaxine, n = 216; placebo, n = 210) included in this analysis, 135 (32%) were perimenopausal and 291 (68%) were postmenopausal at baseline. In both subgroups, improvement from baseline in HAM-D17 scores was significantly greater for desvenlafaxine 50 mg/day than for placebo. Menopause status and time since menopause did not significantly affect HAM-D17 total score. The drug-placebo difference in Sheehan Disability Scale scores was significant in perimenopausal women (-9.3 vs. -5.1, P desvenlafaxine in postmenopausal women. Desvenlafaxine 50 mg/day is effective in treating depression in both perimenopausal and postmenopausal women. Placebo response on measures of functional impairment is lower in perimenopausal women than in postmenopausal women, resulting in a greater apparent treatment benefit with desvenlafaxine among perimenopausal women.

  7. Association of physical fitness, body composition, cardiometabolic markers and adherence to the Mediterranean diet with bone mineral density in perimenopausal women. The FLAMENCO project.

    Science.gov (United States)

    Aparicio, Virginia A; Ruiz-Cabello, Pilar; Borges-Cosic, Milkana; Andrade, Ana; Coll-Risco, Irene; Acosta-Manzano, Pedro; Soriano-Maldonado, Alberto

    2017-05-01

    This study aimed to analyse the association of different components of physical fitness, body composition, cardiometabolic markers and the Mediterranean diet with bone mineral density (BMD) in perimenopausal women, and to test which of these components are independently associated with BMD. The sample comprised 197 perimenopausal women (52.6 ± 4.5 years). Physical fitness was assessed with the "Senior Fitness Test" battery and the handgrip strength and Bruce tests. Fat and lean mass and BMD were measured using dual-energy X-ray absorptiometry. We analysed the markers of metabolic syndrome, C-reactive protein, and components of the Mediterranean diet. Handgrip muscle strength (β = 0.212, P = 0.005), body weight (β = 0.244, P = 0.001), BMI (β = 0.180, P = 0.011) and lean mass (β = 0.379, P  0.05). When all relevant indicators of BMD were simultaneously considered, lean mass was the only 1 showing an independent association with BMD (β = 0.392, P < 0.001), explaining 14% of the BMD variability. In conclusion, muscle strength might be a marker of BMD in perimenopausal women. However, lean mass was the only factor independently associated with BMD. Future research to determine whether increasing lean mass through specific exercise-based interventions contributes to increasing BMD is warranted.

  8. Progress on contraception methods of perimenopausal women%围绝经期妇女避孕方法的研究进展

    Institute of Scientific and Technical Information of China (English)

    柳韦华; 孙彦玲; 高丹凤

    2010-01-01

    This article introduced the progress on perimenopause contraception. Various contraceptive options may be offered to perimenopausal women, including oral contraceptives, tubal ligation, intrauterine devices, barrier methods, hormonal injectables and implants. Recently, new methods of contraception have been introduced presenting high efficacy rates and minor side - effect, such as the monthly injectable system, the contraceptive vaginal ring and the transderimal contraceptive system. The use of the various contraceptive methods during perimenopause holds special benefits and risks that should be carefully balanced, after a thorough consultation and according to each women(s) contraception needs.%本文综述了围绝经期妇女避孕方法 的研究进展,围绝经期妇女可采用多种避孕方法 ,包括口服避孕药、输卵管结扎、宫内节育器,屏障避孕、避孕针和皮下埋植.最近一些新的避孕方法 高效、副作用小,如每月注射的长效避孕针、阴道环和透皮贴剂等.围绝经期采用不同的方法 避孕各有利弊,根据个体需要选择恰当的避孕措施.

  9. Differences in the concentration and correlation of cervical immune markers among HPV positive and negative perimenopausal women.

    Science.gov (United States)

    Marks, Morgan A; Viscidi, Raphael P; Chang, Kathryn; Silver, Michelle; Burke, Anne; Howard, Roslyn; Gravitt, Patti E

    2011-12-01

    Women≥45years of age with persistent HPV infections have distinct peripheral circulating immune profiles. Few studies have comprehensively evaluated the cervical immunologic microenvironment in HPV-positive and HPV-negative perimenopausal women. We collected cervical secretion specimens from 34 high risk HPV (HR-HPV) positive and 44 HR-HPV negative women enrolled in an ongoing prospective cohort assessing the natural history of HPV across the menopausal transition. We used these specimens to quantify concentrations of 27 different immune markers using multiplexed bead-based immunoassays. HR-HPV positive women had significantly higher median concentrations of IL-5 (0.11 ng/mgtotal protein vs. 0.08 ng/mgtotal protein), IL-9 (2.7 ng/mgtotal protein vs. 2.1 ng/mgtotal protein), IL-13 (2.1 ng/mgtotal protein vs. 0.9 ng/mgtotal protein), IL-17 (2.9 ng/mgtotal protein vs. 1.1 ng/mgtotal protein), EOTAXIN (4.1 ng/mgtotal protein vs. 1.1 ng/mgtotal protein), GM-CSF (4.3 ng/mgtotal protein vs. 3.3 ng/mgtotal protein), and MIP-1α (3.5 ng/mgtotal protein vs. 1.9 ng/mgtotal protein) compared to HR-HPV negative women. A shift in the correlation of T-cell and pro-inflammatory cytokines (IFN-γ, IL-5, IL-9, IL-10, IL-12, IL-13, IL-15, and TNF-α) from IL-2 to EOTAXIN was observed between HR-HPV negative and positive women. Higher local concentrations of anti-inflammatory and allergy associated markers, with a shift in T-cell associated cytokine correlation from IL-2 to EOTAXIN, are associated with HPV infection among older women. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Investigation and analysis on health status of community perimenopausal women%社区围绝经期妇女健康状况调查与分析

    Institute of Scientific and Technical Information of China (English)

    梁美金; 黄海青; 林良柳

    2016-01-01

    目的:对围绝经期妇女的健康状况以及围绝经期综合征的影响因素进行调查和分析,为围绝经期妇女的健康教育和预防保健提供参考。方法采用调查问卷对围绝经期妇女进行调查,并从中选取480例组作为研究对象,对其资料进行分析。结果 Kupperman平均评分为(11.32±6.45)分,围绝经期妇女中围绝经期综合征的发生率为76.2%,主要以轻中度为主,分别为29.8%和41.8%,其次为无症状和重度,分别为23.8%和4.6%,围绝经期症状主要包括:乏力(70.6%)、烦躁易怒(62.5%)、关节疼痛(61.3%)、月经紊乱(57.7%)、头痛(52.9%)、眩晕(52.1%)等;其中年龄增长、分娩次数、是否有妇科疾病手术史以及慢性疾病是围绝经期综合征的主要危险因素。结论对围绝经期妇女开展健康教育,合理饮食,服用围绝经期药物,可预防和缓解围绝经期症状,提高妇女的生活质量。%Objective To investigate and analyze the health status of community perimenopausal women and the influence factors, and provide reference for health education and health care of perimenopausal women. Methods A questionnaire was selected for investigating of perimenopausal women and 480 cases were as research objects. All data were analyzed. Results The mean score of Kupperman was ( 11. 32 ± 6. 45 ) . The incidence rate of perimenopausal syndrome was 76. 2%. The mainly symptom was mild to moderate and the incidence rate was 29.8% and 41.8% respectively. The secondly was asymptomatic and severe and the incidence rate was 23. 8% and 4. 6% respectively. The perimenopausal symptoms include: fatigue ( 70. 6%) , irritability (62.5%), joint pain (61.3%), menstrual disorder (57.7%), headache (52.9%), dizziness (52.1%), et al. Age, and delivery times, gynecological surgery history and chronic diseases were major risk factors for perimenopausal syndrome. Conclusions Health education, proper diet

  11. Nutritional education in the primary prevention of osteoporosis in perimenopausal and postmenopausal women

    Directory of Open Access Journals (Sweden)

    Joanna Woźniak-Holecka

    2014-03-01

    Full Text Available Osteoporosis affects millions of people in the whole world and brings about far-reaching physical and psycho-social consequences for patients and financial ones for the health care system, and therefore it is classified as one of public health problems and treated as a social disease. Women belong to the increased osteoporosis illness risk group due to lower top bone mass reached earlier in life as compared to men and due to hormonal changes occurring in the menopausal period, which affect loss of the bone mineral density (BMD. Limitation of the osteoporosis-related financial and social costs increase requires efficient preventive actions on the level of early, primary, secondary or tertiary prevention. At all the four osteoporosis prevention phases, the crucial role is played by health education and nutrition education, the latter being the key element of the former one. The nutritional education purpose is to acquaint patients with nutrition recommendations that are the basic element of the osteoporosis prevention and to make them change their nutrition habits, which will improve their osseous metabolism. The education should be based on results of the latest scientific researches and focus on recommendations relating to proper supplementing of calcium and vitamin D, simultaneously including all the other nutrition components, necessary to decrease the osteoporosis risk. The primary prevention oriented to a specific group at risk for osteoporosis, including peri- or postmenopausal women, should be provided in cooperation with the different levels’ medical professionals and it should focus on causing positive changes in patients both as regards nutrition habits and physical activities.

  12. Soy and legume seeds as sources of isoflavones: selected individual determinants of their consumption in a group of perimenopausal women

    Directory of Open Access Journals (Sweden)

    Maria Gacek

    2014-03-01

    Full Text Available The aim of this study was to analyze selected individual determinants of consumption of soy products and legumes by menopausal women. The analyzed individual characteristics included the level of general self-efficacy, optimism, and satisfaction with life. The study, using a questionnaire for the assessment of food product consumption frequency, and psychological tests (GSES, LOT-R, SWLS, was conducted in a group of 320 women aged between 45 and 55 years. Spearman’s coefficient of rank correlation and the Kruskal-Wallis test with the Dunn test for multiple comparisons were used for statistical analysis (p < 0.05. Material and methods: The analyzed 45-55-year-old women consumed legume seeds several times a month on average, while the frequency of soy/soy product consumption was lower than once a month. Statistical analysis revealed that the frequency of soy product consumption increased with the level of self-efficacy, optimism and satisfaction with life (p < 0.01. Also the increased frequency of legume seed consumption was associated with higher level of optimism and satisfaction with life (p < 0.01. Results: Intergroup comparisons of the average consumption frequency of these products confirmed that legume seeds were significantly more frequently chosen by women characterized by high rather than low levels of optimism (3.36 vs. 2.62, p < 0.001 and satisfaction with life (3.36 vs. 2.65, p < 0.01. Also soy products were preferred significantly more often by women with higher levels of optimism (2.00 vs. 1.38, p < 0.05 and satisfaction with life (2.02 vs. 1.39, p < 0.05. Conclusions : The consumption of legume seeds, and especially soy products, was revealed to be very low among perimenopausal women, and varied depending on the analyzed individual traits, with a tendency to more frequent ingestion by individuals with higher levels of self-efficacy, optimism, and satisfaction with life.

  13. EVALUATION OF THE EFFECTS OF PILATES MAT EXERCISE PROGRAM ON SOME FITNESS PARAMETERS AND WEIGHT LOSS AT MIDDLE AGED PERIMENOPAUSAL SEDENTARY WOMEN

    Directory of Open Access Journals (Sweden)

    Fatma ARSLAN

    2012-04-01

    Full Text Available Menopause starts when menstruation permanently cuts off. Perimenopause was defined asirregular bleeding (6 weeks to 4 months and/or vasomotor symptoms such as sweating and hot flushes(3. Therefore, the purpose of this study was to examine the effects of intermittent exercise on bodycomposition, fat distribution and vasomotor symptoms in perimenopausal sedentary women.In this study participated that total 66 middle-aged with the phenomenon of hot flushesoverweight sedentary women as volunteers. Body weight, Body composition (via skinfolds caliper, waisthip ratio, waist circumference and body fat percentage were obtained from sedentary women. Besidessubjects were asked menopausal bleeding patterns (including vasomotor symptoms states withinformation form. The measurements were taken twice as before and after Pilates mat training programbeing applied a 6-week series of one hour exercise three days per week. The control group did notparticipate in any activity exercise program during the six-week period. There were significant differencesbetween pretest and posttest for weight, body mass index, waist circumference, waist hip ratio, fatpercentage and body composition parameters in exercise group (p<0,05. Also, there were not significantdifferences between pretest and posttest for same measurements in control group. According to subjects'answers to was found that pilates mat exercise had significantly effective on hot flushes from vasomotorsymptoms at sedentary women.As a result, the findings support of pilates mat exercises effects on weight loss and body compositionparameters. Pilates mat exercises can have long-term benefits for women undergoing the menopausal transition.

  14. 围绝经期妇女抑郁症状影响因素调查%Investigation on the effect factors of depression symptom among perimenopausal women

    Institute of Scientific and Technical Information of China (English)

    顾磊; 杜莉; 施红; 钱晓敏; 谭晶; 秦敏; 纪若思; 沈谦; 朱丽萍

    2011-01-01

    Objective: To explore the current situation and effect factors of depression symptom among perimenopausal women and their psychological health demands in partial urban areas in Shanghai. Methods: General condition questionnaire, modified menopausal Kupperman assessment scale, social support rating scale (SSRS), patient health questionnaire depression module (PHQ-9) and menopausal mental health care attitude and need scale were used to survey 935 women aged 45 ~ 59 years old who received general investigation in a community in Shanghai from December 2010 to February 2011. Results: The incidence of depression in perimenopausal women was 24. 8%. The incidences of depression in native women and floating women were 22. 7% and 50. 7%, respectively. The effect factors of depression in perimenopausal women included census registration, the degree ofdysmenorrhea, children leaving their home for a long time within one year, serious diseases, cacesthesia, arthralgia and myalgia, climacteric syndrome, subjective support rating, objective support rating,and so on. The consciousness and knowledge of health care in perimenopausal women: 39. 8% of the perimenopausal women did not care about mental health care, 69. 5% of the perimenopausal women obtained health knowledge from media mainly, and 61.9% of the perimenopausal women obtained health knowledge from newspapers and magazines mainly. Conclusion: The incidence of depression among perimenopausal women is high. It is associated with a variety of social, psychological and biological factors. Mental health care provided for perimenopausal women should be included in women health work.%目的:探讨上海市部分城区围绝经期妇女抑郁症状发生现状、影响因素及其心理保健需求.方法:采用一般情况调查表、改良更年期Kupperman评分量表、社会支持评定量表、病人健康问卷抑郁量表、围绝经期妇女心理卫生保健态度及需求调查表,于2010年12月~2011

  15. CYP1A1 and CYP1B1 polymorphisms and their association with estradiol and estrogen metabolites in women who are premenopausal and perimenopausal.

    Science.gov (United States)

    Sowers, MaryFran R; Wilson, Angela L; Kardia, Sharon R; Chu, Jian; McConnell, Daniel S

    2006-09-01

    The purpose of this study was to relate measured concentrations of estradiol (E2) and the urinary estrogen metabolites 2-hydroxyestrone (2-OHE1) and 16alpha-hydroxyestrone (16alpha-OHE1) to single nucleotide polymorphisms (SNPs) from CYP1A1 and CYP1B1, the primary genes involved in estrogen catabolism. We investigated the association of 4 CYP1A1 SNPs (CYP1A1 rs4646903, CYP1A1 rs1531163, CYP1A1 rs2606345, and CYP1A1 rs1048943) and 2 CYP1B1 SNPs (CYP1B1 rs162555 and CYP1B1 rs1056836) to circulating serum E2 concentrations and the urinary estrogen metabolites 2-OHE1 and 16alpha-OHE1. The associations were evaluated in 1,340 participants of 4 racial/ethnic groups from the Study of Women's Health Across the Nation (SWAN) who were premenopausal and perimenopausal. There was substantial variation in the allele frequencies of the SNPs for African American and Caucasian women. There was, however, remarkable comparability between Chinese and Japanese women; their CYP1A1 and CYP1B1 allele frequencies differed by only < or =11%. There was significant variation in E2 concentrations by genotype within racial/ethnic group for CYP1A1 rs2606345. In particular, Japanese women with the CC genotype had lower E2 concentrations than did Japanese women with the AC genotype. Chinese women with the CC genotype had higher 2-OHE1 concentrations than did Chinese women with the AC genotype. Further, African American women with the CC genotype had higher 16alpha-OHE1 concentrations than did those with other genotypes. CYP1A1 rs2606345 may play an important role in estrogen metabolism in women who are premenopausal and perimenopausal.

  16. Perimenopause as a neurological transition state.

    Science.gov (United States)

    Brinton, Roberta D; Yao, Jia; Yin, Fei; Mack, Wendy J; Cadenas, Enrique

    2015-07-01

    Perimenopause is a midlife transition state experienced by women that occurs in the context of a fully functioning neurological system and results in reproductive senescence. Although primarily viewed as a reproductive transition, the symptoms of perimenopause are largely neurological in nature. Neurological symptoms that emerge during perimenopause are indicative of disruption in multiple estrogen-regulated systems (including thermoregulation, sleep, circadian rhythms and sensory processing) and affect multiple domains of cognitive function. Estrogen is a master regulator that functions through a network of estrogen receptors to ensure that the brain effectively responds at rapid, intermediate and long timescales to regulate energy metabolism in the brain via coordinated signalling and transcriptional pathways. The estrogen receptor network becomes uncoupled from the bioenergetic system during the perimenopausal transition and, as a corollary, a hypometabolic state associated with neurological dysfunction can develop. For some women, this hypometabolic state might increase the risk of developing neurodegenerative diseases later in life. The perimenopausal transition might also represent a window of opportunity to prevent age-related neurological diseases. This Review considers the importance of neurological symptoms in perimenopause in the context of their relationship to the network of estrogen receptors that control metabolism in the brain.

  17. Physical activity, evaluation of menopause, life satisfaction and influence tactics in marriage of perimenopausal women

    Directory of Open Access Journals (Sweden)

    Eugenia Mandal

    2016-10-01

    Full Text Available Background Domination of the biomedical approach to menopause may imply creation of negative attitudes to the phenomenon, and at the same time negatively affect women’s life satisfaction and behaviour in the family. It is assumed that physical activity may be a defensive factor, as this type of activity may reduce the intensity of menopause symptoms. The aim of the research was to determine the relation between menopause evaluation, life satisfaction and tactics of influence employed in marriage by women who differ in involvement in physical exercise. Participants and procedure The research was conducted among 90 women, at the age of 45-55: 45 physically active women and 45 women who do not engage in any physical activity. The following research methods were used: the Menopause Evaluation Scale, the Satisfaction With Life Scale (SWLS and the Questionnaire of Influence in Close Relations of Women and Men. Results Positive evaluation of menopause was related to involvement in physical exercise as well as to a stronger tendency to use positive strategies of exerting influence on one’s spouse. The research also showed a slight correlation between life satisfaction and involvement in physical exercise. Negative evaluation of menopause was related to avoiding physical activity. Conclusions Physical activity is more frequently related to a positive attitude towards menopause and the use of more positive tactics of exerting influence on one’s spouse, and slightly positively conducive to one’s life satisfaction level.

  18. 围绝经期妇女保健指导%Perimenopausal Women's Health Guidance

    Institute of Scientific and Technical Information of China (English)

    龙海梅; 成亚芹

    2014-01-01

    Refers to the peri menopausal women menopause before and after a period of time, due to fluctuations in hormone levels can appear a series of physical and mental abnormalities,this paper aims to implement health care guidance to improve menopausal women peri menopausal woman's physical and mental health, improve the quality of life of women in the menopausal transition.%围绝经期指妇女绝经前后的一段时间,期间由于激素水平的波动可出现一系列生理和心理的异常,文章旨在通过对围绝经期妇女实施保健指导以改善围绝经期妇女的身心健康,提高妇女围绝经期的生活质量。

  19. 浅析妇女更年期(围绝经期)保健%Analysis of Women's Menopause (Perimenopausal) health care

    Institute of Scientific and Technical Information of China (English)

    徐兰

    2014-01-01

    In the life of women need to experience many special period, such as: from the growth period and sexual activity in normal times, to reduce women's fertility and sexual life to stop completely, then entered old age is light, the medical community to this period is called menopause, during this period the biggest sign is menopause women in this process, but is not accomplish at one stroke, it can be divided into three periods, namely: premenopausal, perimenopausal and postmenopausal women, they are cal ed perimenopause. Therefore, women at this stage should pay more at ention to self health care, improve health consciousness, pay at ention to their diet and habits, to reduce the incidence of the disease. This paper wil take the perimenopausal women's health consciousness as a starting point, analyzes the necessity of menopause women health care, and put forward the method of conventional care, reduce the incidence of disease.%妇女一生中需要经历很多特殊的时期,如院从生育时期和性活动正常时期,到妇女生育能力和性生活的减少再到完全停止,继而进入了老年,医学界把这一时期称之为更年期,这一时期妇女最大的标志就是绝经,而这一过程又不是一蹴而就的,它又分为三个时期,即院绝经前期、绝经期和绝经后期,它们都被称为围绝经期。因此,妇女在这个阶段更应该注意自我保健,减少疾病的发生。本文将以围绝经期妇女的健康意识为起点,分析围绝经期妇女进行保健的必要性,并提出常规的保健方法,降低疾病的发生率。

  20. Study of epidemiological features of health problems in perimenopausal and postmenopausal women in an urban community

    Directory of Open Access Journals (Sweden)

    Manjusha K Deotale

    2015-04-01

    Full Text Available Introduction: Menopause is said to be universal reproductive phenomenon. Menopause although not a disease is associated with annoying physiological changes and varied symptoms such as hot flushes, night sweats, urinary and genital changes, dyspareunia, insomnia and many psychological dysfunctions such as anxiety, depression, lack of concentration and decreased self-esteem. Every woman's experience of the menopause is unique; she may experience all of the symptoms or none of them. Some find the transition barely noticeable while others find it life altering. Materials and Methods: A cross-sectional study was conducted among peri and postmenopausal women aged 40-60 years residing at Government colony, Bandra, Mumbai, Maharashtra for a period of 1-year. A predesigned and pretested questionnaire was used for collecting data. A booklet on "care during menopause" was used for giving health education. Results: In this study, mean age at natural menopause was 45.32 years (standard deviation ±2.79. Our study participants reported mostly muscular and joint pain (44.86%, urological symptoms (23.43%, vasomotor symptoms (21.14%, vulvovaginal symptoms (19.43%, psychological symptoms (15.14%, weight gain (14.86%, psychosexual symptoms (11.43% and hirsutism (1.43%. Conclusions: There is a necessity of a multidisciplinary approach to the problems of menopause with more stress on promotive and preventive interventions. There should be provision of relevant health services, health education and promotional activities to cope up with the health needs of women in their postmenopausal years.

  1. The effective evaluation of nursing intervention on perimenopausal women%综合护理干预对围绝经期妇女效果研究

    Institute of Scientific and Technical Information of China (English)

    周丽英; 张惠玲; 黄海雁; 何爱嫦

    2011-01-01

    Objective : To explore the effect of nursing intervention on improving the health of perimenopausal women. Methods : 130 perimenopausal women ,were carried out health education, diet and exercise guide, psychological intervention and medication guide etc intervention by telephone interviews. clinic follow - up, health education lectures, health knowledge brochure, and other forms of their education. after intervention 6 months to evaluate the intervention effect by WHO live quality measuring instrument, symptoms such as self rating scale. Results:The 130 perimenopausal women major clinical symptoms improved, psychological state improve, quality of life obviously improved after 6 months, compared with before intervention.There was statistically significant difference ( P < 0. 05 ). Conclusion: Women who give to menopausal transition, after the comprehensive nursing intervention psychological status markedly improved significantly relieve symptoms, so as to improve the quality of life.%目的:探讨护理干预对改善围绝经期妇女健康的效果,以帮助她们顺利度过这一特殊的时期.方法:通过采用电话随访、健康教育讲座、宣传栏、门诊随访及健康知识小册子等形式,对130例围绝经期妇女实施健康教育、饮食运动指导、心理干预及用药指导等综合护理干预.6个月后应用WHO生存质量测定量表、症状自评量表等评估干预效果.结果:6个月后,130例围绝经期妇女主要临床症状改善,心理状态改善,生活质量明显提高,与干预前相比有统计学意义(P<0.05).结论:对围绝经期妇女实施综合护理干预后,其心理状态明显改善,症状显著减轻,生活质量得到提高.

  2. Expulsed myoma in the perimenopause

    Directory of Open Access Journals (Sweden)

    Letícia de Arruda Camargo

    2012-11-01

    Full Text Available ABSTRACT Leiomyomas are benign neoplasms that affect the uterine smooth muscle. They result from a complex interplay of hormones, growth factors, cytokines and the presence of a genetic factor, which is believed to be an important factor for its appearance. These tumors most often affect women in reproductive age. Because of this fact, the appearance of leiomyomas in women during the perimenopause is a rare occurrence, exemplified by the paucity of reports in the medical literature and thus, this is a case report of an “expulsed myoma during perimenopause”.

  3. A survey and analysis of menopausal symptoms in perimenopausal women and its influencing factors%围绝经期妇女的绝经症状及其影响因素调查分析

    Institute of Scientific and Technical Information of China (English)

    李华; 汪晖

    2015-01-01

    Objective:To probe into menopausal symptoms in perimenopausal women and its influencing factors. Methods:The general questionnaire and menopausal symptoms rating scale were used to investigate 417 cases of perimenopausal women.Results:The main influencing factors of influencing perimenopausal symptoms included family relations,height shortening,history of chronic disease or not,sleep,menopausal status,sexual life and drinking history.Conclusion:The incidence of menopausal symptoms among perimenopausal women is relatively common,widely and with many influencing factors.Therefore,health care providers should take appropriate in-terventions according to the individual situation,and then to improve the status of perimenopausal symptoms.%[目的]探讨围绝经期妇女的围绝经期症状及影响因素。[方法]采用一般情况调查表和绝经症状评定量表对417名围绝经期妇女进行调查。[结果]围绝经期症状发生率为80.6%。影响围绝经期症状的主要因素是家庭关系、身高缩短情况、有无慢性病史、睡眠、绝经状态、性生活、饮酒史。[结论]围绝经期妇女绝经症状发生率较为普遍、广泛,影响因素众多,建议健康保健人员根据个人情况采取适宜的干预措施,从而改善其围绝经期症状状况。

  4. Perimenopausal Bleeding and Bleeding After Menopause

    Science.gov (United States)

    ... Patients About ACOG Perimenopausal Bleeding and Bleeding After Menopause Home For Patients Search FAQs Perimenopausal Bleeding and ... 2011 PDF Format Perimenopausal Bleeding and Bleeding After Menopause Gynecologic Problems What are menopause and perimenopause? What ...

  5. Perimenopausal Bleeding and Bleeding After Menopause

    Science.gov (United States)

    ... Patients About ACOG Perimenopausal Bleeding and Bleeding After Menopause Home For Patients Search FAQs Perimenopausal Bleeding and ... 2011 PDF Format Perimenopausal Bleeding and Bleeding After Menopause Gynecologic Problems What are menopause and perimenopause? What ...

  6. 围绝经期女性骨质疏松症的膳食营养策略%Dietary nutrition measures for osteoporosis in perimenopausal women

    Institute of Scientific and Technical Information of China (English)

    任桂英; 王丽; 盛秋; 于学文

    2014-01-01

    The level of estrogen descends in perimenopausal women because of hypoovarianism, which could reduce the assimilation of calcium.Meanwhile, osteoclast can not be controlled and the new bone can not form timely, thus the bone density is reduced and osteoporosis occurs.Preventing osteoporosis is important, and dietary nutrition is closely related with osteoporosis, which is one of the important measures to prevent osteoporosis.This paper analyzed the effect of different nutrients on the prevention of osteoporosis, and discussed how to diet and exercise scientifically and reasonably to prevent osteoporosis in perimenopausal women.%妇女进入围绝经期以后,由于卵巢功能减退,雌激素波动性下降,会减少对钙的吸收,同时破骨过程增加,新生骨骼无法及时形成,骨骼密度降低,容易引起骨质疏松症。骨质疏松症重在预防,膳食营养与骨质疏松症关系密切,其是预防骨质疏松症的重要措施之一。该文分析不同营养物质在预防骨质疏松症中的作用,阐述科学合理饮食和运动,预防围绝经期女性骨质疏松症。

  7. 民族高校女职工围绝经期症状及保健需求调查分析%Investigation and Analysis of Perimenopausal Symptoms and Health Care Demand of the Nationalities University Women

    Institute of Scientific and Technical Information of China (English)

    余学红

    2016-01-01

    目的::了解民族高校妇女的围绝经期症状及保健需求情况,为围绝经期妇女保健工作提供科学依据.方法:采用问卷调查的方法,对民族高校647例40~60岁妇女进行调查.结果:调查对象围绝经期相关症状发生率为77.13%,其主要症状依次为:记忆力下降(65.84%)、情绪波动(64.30%)、失眠(63.83%)、潮热(58.73%)、月经紊乱(54.40%)等.各年龄组围绝经期症状发生率比较,差异有统计学意义(p<0.05),且随着年龄增大,其发生率逐渐增高.围绝经期妇女保健需求主要为定期全面体检和预防骨质疏松;希望得到围绝经期健康咨询与指导的妇女占53.48%.结论:民族高校妇女围绝经期相关症状发生率高,对围绝经期保健知识及服务需求迫切.相关卫生服务部门应高度重视,实施干预模式,加强对民族高校围绝经期妇女的健康管理,积极开展全科医疗卫生保健服务,以提高围绝经期妇女的生活质量.%Objective:To understand the situation of perimenopausal symptoms and health care demand in nationalities university women, to community perimenopause women's health care and provide scientific basis for. Methods: Using the method of questionnaire survey was conducted on the 647 cases of 40 ~60 years old women in university . Results:The survey of menopausal symptoms, occurrence rate is 77. 13%, the incidence of main symptoms were:the decline of memory (65. 84%), mood swings (64. 30%), insomnia (63. 83%), fever (58. 73%), menstrual disorder (54. 40%). Each age group of perimenopausal symptoms occur rate compares difference to have statistical sense (p< 0. 05), increases with age, the incidence rate increase. Perimenopausal health care demand mainly for the regular physical examination and prevention of osteoporosis, hope to get the perimenopausal health counseling and guidance of perimenopausal women accounted for 53. 48%. Conclusion: the perimenopausal symptoms of

  8. Path analysis of factors that influence the quality of life of perimenopausal women%围绝经期女性生活质量影响因素的路径分析

    Institute of Scientific and Technical Information of China (English)

    吕春梅; 徐一丹; 申思; 于莉佳

    2016-01-01

    目的:以心理应激模型为理论框架探讨围绝经期女性生活质量的影响因素。方法采用一般资料调查表、生活质量测定量表简表( SF-12)、自我效能感量表、艾森克人格问卷简式量表中国版( EPQ-RSC)、简易应对方式问卷及社会支持评定量表对747名围绝经期女性进行调查,并采用路径分析的方法对假设模型进行检验和修正。结果围绝经期女性的生活质量得分为(56.72±8.47)分;消极应对、社会支持利用度、内外向人格特征、围绝经期综合征程度可以直接影响生活质量,也可以通过自我效能间接影响生活质量;自我效能是围绝经期女性生活质量的最重要预测变量。结论围绝经期女性的生活质量有待提高,围绝经期综合征、自我效能、消极应对、社会支持利用度及内外向人格特征是围绝经期女性生活质量的影响因素。%Objective To explore the factors that influence the quality of life of perimenopausal women which take the stress model as the theoretical framework. Methods A total of 747 perimenopausal women were investigated with the general questionnaire, SF-12, self-efficacy questionnaire, Eysenck personality questionnaire short scale for Chinese (EPQ-RSC), the simplified coping style questionnaire, and the social support rating scale. After surveying, the supposition model was confirmed and revised by path analysis. Results The quality of life perimenopausal women was (56.72±8.47), which was lower than the score of women without perimenopausal syndrome ( 71. 24 ± 5. 66 ) ( P<0. 05 ) . The correlation analysis and structural equation analysis showed that negative coping, utilization of social support, personality characteristics of outgoing and introvert people and degree of perimenopausal syndrome all can directly influence the quality of life ( P<0. 0. 5 ) , and also can indirectly influence the quality of life though self-efficiency. Self

  9. Survey of reproductive health status and service needs of perimenopausal women in Shunde%顺德区围绝经期妇女生殖健康状况及服务需求调查

    Institute of Scientific and Technical Information of China (English)

    刘曼丽; 张朝红; 廖翠英; 郖健蓉; 许振付; 胡妙芳; 谢映君; 关瑞芬

    2015-01-01

    目的:通过对顺德地区的围绝经期年龄妇女生殖健康状况调查,希望能够对顺德地区的问题提供针对性的服务,提高生活质量。方法:按1∶1比例随机抽查顺德区大良、容桂、伦教三个镇街40~60岁围绝经期妇女,通过调查问卷、面对面访谈方式进行调查。结果:佛山市顺德区妇女自然绝经年龄平均48.7岁,围绝经期综合征发生率为76%,症状前三位是疲乏、失眠、骨关节痛,21%的人了解激素替代疗法(HRT),5%的人使用过 HRT。结论:围绝经期综合征严重影响围绝经期妇女身心健康,应引起高度重视并采取积极有效措施进行干预。%Objectives:Through survey of the reproductive health status of perimenopausal women in Shun-de,to provide targeted services for the problem in Shunde and improve the life quality of perimenopausal women. Methods:The perimenopausal women aged 40 -60 in three towns including Shunde,Ronggui,Lundun District were selected by way of stratified methods and probability sampling rate,and surveyed through questionnaires and face to face interviews.Results:The average age of natural menopause was 48.7 years old,and incidence rate of perimenopausal syndrome was 76%,with the top three symptoms being fatigue,insomnia,bone and joint pain. 21% of people knew about hormone replacement therapy (HRT)and 5 % of people had used HRT.Conclusion:The perimenopausal syndrome seriously affects physical and mental health of perimenopausal women;we should pay close attention and take positive and effective measures to intervene the health status.

  10. Optimal management of perimenopausal depression

    Directory of Open Access Journals (Sweden)

    Barbara L Parry

    2010-06-01

    Full Text Available Barbara L ParryDepartment of Psychiatry, University of California, San Diego, USAAbstract: Only recently has the perimenopause become recognized as a time when women are at risk for new onset and recurrence of major depression. Untreated depression at this time not only exacerbates the course of a depressive illness, but also puts women at increased risk for sleep disorders, cardiovascular disease, diabetes, and osteoporosis. Although antidepressant medication is the mainstay of treatment, adjunctive therapy, especially with estrogen replacement, may be indicated in refractory cases, and may speed the onset of antidepressant action. Many, but not all, studies, report that progesterone antagonizes the beneficial effects of estrogen. Although some antidepressants improve vasomotor symptoms, in general they are not as effective as estrogen alone for relieving these symptoms. Estrogen alone, however, does not generally result in remission of major depression in most (but not all studies, but may provide benefit to some women with less severe symptoms if administered in therapeutic ranges. The selective serotonin reuptake inhibitors (SSRIs in addition to estrogen are usually more beneficial in improving mood than SSRIs or estrogen treatment alone for major depression, whereas the selective norepinephrine and serotonin reuptake inhibitors do not require the addition of estrogen to exert their antidepressant effects in menopausal depression. In addition to attention to general health, hormonal status, and antidepressant treatment, the optimal management of perimenopausal depression also requires attention to the individual woman’s psychosocial and spiritual well being.Keywords: menopause, depression, management

  11. Influence of Hypertension,Abnormal Lipid,Obesity to Coronary Heart Disease in Perimenopausal Women%高血压/血脂异常及肥胖对围绝经期妇女冠心病的影响

    Institute of Scientific and Technical Information of China (English)

    孙宇光; 刘辉霞

    2011-01-01

    目的 探讨血压、血脂异常及肥胖三种危险因素与围绝经期妇女冠心病的相关性.方法 选择100例患有高血压/血脂异常/肥胖围绝经期妇女(观察组)与100例健康围绝经期妇女(对照组)的冠心病发病率作比较.结果 观察组心血管疾病发病率显著高于对照组,且两种或三种合并情况的患病率要明显高于其他组.结论 高血压、血脂异常及肥胖是围绝经期妇女冠心病发病的重要影响因子.%Objective To study the correlation of hypertension, abnormal lipid and obesity with coronary heart disease in perimenopausal women. Methods The morbidity of coronary heart disease between the obseration group( 100 cases of perimenopausal women with hypertension, abnormal lipid and obesity ) and the control group( 100 cases of healthy perimenopausal women ) were compared. Results The morbidity of cardiovascular disease in the obseration group was significantly higher than that of the control group. The morbidity of two or three combination was obviously higher than that of the other group. Conclusion Hypertension,abnormality lipid and obesity were important factors for the morbidity of coronary heart disease in perimenopausal women.

  12. 桥本氏甲状腺炎与围绝经期妇女雌激素水平相关性的临床研究%The clinical research of perimenopausal women with Hashimoto's thyroiditis of estrogen level

    Institute of Scientific and Technical Information of China (English)

    刘智健

    2013-01-01

    Objective To observe the perimenopausal patients with Hashimoto's thyroiditis estradiol changes and explore its significance. Methods 32 female perimenopausal patients with Hashimoto's thyroiditis, 32 perimenopausal women volunteers, detect the level of estradiol after 13 days of the period. Detection of three thyroid function parameters, anti-thyroid autoantibodies parameters for the diagnosis of Hashimoto's thyroiditis. Results The estradiol level of perimenopause Hashimoto's thyroiditis patients is 284.47±82.17ng/L, and the control group is 169.62±61.05ng/L, which is a significant difference. TGAb and E2 levels were positively correlated(r=0.519, P <0.05). Conclusion The perimenopausal patients with Hashimoto's thyroiditis elevated estradiol levels compared to the control group, suggesting that estrogen may in perimenopausal women Hashimoto's thyroiditis play a role in the pathogenesis.%目的:观察围绝经桥本氏甲状腺炎患者雌二醇的改变并探讨其意义。方法选取围绝经期桥本氏甲状腺炎患者32例,围绝经期女性志愿者32例,在月经后第13d检测其雌二醇水平。检测患者甲功三项(FT3、FT4、TSH),抗甲状腺自身抗体(TGAb、TMAb)指标诊断桥本氏甲状腺炎。结果围绝经期桥本氏甲状腺炎病例雌二醇284.47±82.17ng/L,对照组雌二醇169.62±61.05ng/L,两者相比有显著差异。患者血清E2与TGAb水平呈显著正相关(r=0.519,P <0.05)。结论围绝经期桥本氏甲状腺炎患者雌二醇水平相比对照组升高,推测雌激素可能在围绝经期妇女桥本氏甲状腺炎发病过程中起一定作用。

  13. Utilización habitual de medicamentos en mujeres perimenopáusicas residentes en Jaca Routine drug utilization in perimenopausal women living in Jaca (Spain

    Directory of Open Access Journals (Sweden)

    María Silvia Sanclemente Pérez

    2009-08-01

    Full Text Available Objetivo: Describir la utilización habitual de medicamentos en mujeres perimenopáusicas y estudiar posibles factores relacionados. Métodos: Estudio observacional mediante entrevista directa en mujeres de 45 a 64años de edad adscritas a la zona de salud de Jaca. Resultados: El 69,4% de las mujeres consumían medicamentos de forma habitual, el 58,6% de las que tenían entre 45 y 54años, y el 81,6% de las de 55 a 64años (p=0,002. La probabilidad de consumir fármacos aumentaba con estar en la posmenopausia (p=0,011, referir alguna enfermedad crónica (pObjective: To describe routine drug utilization in perimenopausal women and to analyze related factors. Methods: We performed an observational study though face-to-face interviews with women aged 45-64 years old living in the health district of Jaca (Spain. Results: Among the women studied, 69.4% routinely used drugs: 58.6% of women aged 45-54 years old and 81.6% aged 55-64 (p=0.002. Factors associated with a greater probability of drug use were postmenopausal status (p=0.011, reported chronic diseases (p<0.001, poor or very poor self-perceived health (p=0.009, and having consulted a general physician at least once in the previous year (p=0.005. Conclusions: Routine drug utilization was frequent in the women studied. Drug utilization was associated with postmenopausal status, perceived health problems, and visits to general physicians.

  14. Study on the correlation between estrogen level in perimenopausal women and Hashimoto's thyroiditis%围绝经期女性雌激素水平与桥本氏甲状腺炎的相关性研究

    Institute of Scientific and Technical Information of China (English)

    常伟勤; 李凤; 吴书莹; 张琨

    2016-01-01

    Objective Through the analysis of the change of estrogen in perimenopausal women who suffered with hashimoto's thyroiditis,to explore the relationship between estrogen level and perimenopausal women Hashimoto's thy-roiditis.Methods Selected 40 cases of perimenopausal women who suffered with hashimoto's thyroiditis and 40 healthy volunteers of perimenopausal women,in the fourteenth days of menstruation dettectted the Estradiol levels.The diagno-sis of patients with Hashimoto bridges rely mainly on thyroid function three namely including FT3,FT4,TSH and the thyroid autoimmune antibodies including anti thyroglobulin antibody (TGAB)and anti thyroid peroxidase antibody (TPOAb).Results The average estradiol level in perimenopausal patients was 313.19±49.27 pg/ml,the estradiol lev-el in the control group was 186.26±22.12 pg/ml,the difference between them was statistically significant.Conclusion The level of the estrogen in perimenopausal women who suffered with hashimoto's thyroiditis compared with the con-trol group is significantly increased,the difference between them was statistically significant.It can be inferred that the estrogen may play a role in the pathogenesis of perimenopausal women who suffered with hashimoto's thyroiditis.%目的:通过分析处于围绝经期的桥本氏甲状腺炎女性患者体内雌激素的变化,探讨围绝经期女性雌激素水平变化与桥本氏甲状腺炎的相关性。方法选取处于围绝经期的桥本氏甲状腺炎女性患者40例,健康围绝经期女性志愿者40例,均在月经第14天检测其体内雌二醇水平。桥本氏甲状腺炎患者的诊断主要依靠甲功三项即 FT3、FT4、TSH 及甲状腺自身免疫性抗体包括抗甲状腺球蛋白抗体(TG-Ab)、抗甲状腺过氧化物酶抗体(TPO-Ab)。结果围绝经期桥本氏甲状腺炎患者体内雌二醇水平为313.19±49.27 pg/ml,对照组雌二醇水平为186.26±22.12 pg/ml,两者相比差异有统计学

  15. Cost-effectiveness of an exercise intervention program in perimenopausal women: the Fitness League Against MENopause COst (FLAMENCO) randomized controlled trial.

    Science.gov (United States)

    Carbonell-Baeza, Ana; Soriano-Maldonado, Alberto; Gallo, Francisco Javier; López del Amo, María Puerto; Ruiz-Cabello, Pilar; Andrade, Ana; Borges-Cosic, Milkana; Peces-Rama, Antonio Rubén; Spacírová, Zuzana; Álvarez-Gallardo, Inmaculada C; García-Mochón, Leticia; Segura-Jiménez, Víctor; Estévez-López, Fernando; Camiletti-Moirón, Daniel; Martín-Martín, Jose Jesús; Aranda, Pilar; Delgado-Fernández, Manuel; Aparicio, Virginia A

    2015-06-17

    The high prevalence of women that do not reach the recommended level of physical activity is worrisome. A sedentary lifestyle has negative consequences on health status and increases health care costs. The main objective of this project is to assess the cost-effectiveness of a primary care-based exercise intervention in perimenopausal women. The present study is a Randomized Controlled Trial. A total of 150 eligible women will be recruited and randomly assigned to either a 16-week exercise intervention (3 sessions/week), or to usual care (control) group. The primary outcome measure is the incremental cost-effectiveness ratio. The secondary outcome measures are: i) socio-demographic and clinical information; ii) body composition; iii) dietary patterns; iv) glycaemic and lipid profile; v) physical fitness; vi) physical activity and sedentary behaviour; vii) sleep quality; viii) quality of life, mental health and positive health; ix) menopause symptoms. All outcomes will be assessed at baseline and post intervention. The data will be analysed on an intention-to-treat basis and per protocol. In addition, we will conduct a cost effectiveness analysis from a health system perspective. The intervention designed is feasible and if it proves to be clinically and cost effective, it can be easily transferred to other similar contexts. Consequently, the findings of this project might help the Health Systems to identify strategies for primary prevention and health promotion as well as to reduce health care requirements and costs. ClinicalTrials.gov Identifier: NCT02358109. Date of registration: 05/02/2015.

  16. Regional and hormone-dependent effects of apolipoprotein E genotype on changes in bone mineral in perimenopausal women

    DEFF Research Database (Denmark)

    Gerdes, Lars Ulrik; Vestergaard, P; Hermann, Pernille;

    2001-01-01

    , whereas serum levels of alkaline phosphatase and its bone isoenzyme were higher in women with APOE 2-2 and APOE 2-3 than in women with APOE 3-3 and APOE 3-4 and lower in women with APOE 4-4. Among women not receiving hormonal-replacement therapy (HRT; n = 262), those with APOE 2-2 and APOE 2-3 had 30......-40% lower rates of femoral neck and total hip bone mineral loss than women with APOE 3-3 and APOE 3-4, whereas the rates of mineral loss in other skeletal regions did not differ between these APOE genotypes. Women with APOE 4-4 appeared to have lower rates of bone mineral loss in all regions. Women treated...... with hormones throughout the follow-up period (n = 113) gained bone mineral, and women with APOE 3-4 and APOE 4-4 gained relatively more mineral than other women. A comparison of untreated and treated women with APOE 2-3, APOE 3-3, and APOE 3-4 suggests a possible modification of the effect of APOE genotype...

  17. Sleep quality and influencing factors of perimenopausal women in Ningbo region%宁波地区围绝经期妇女睡眠质量调查及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    毛雪锋; 邵璐; 赵鑫; 卢小情; 郑倩; 张金堂; 王伟; 董长征

    2011-01-01

    Objective: To investigate the sleep quality and influencing factors of perimenopausal womem in Ningbo region. Methods: A total of 527 perimenopausal women who lived in Ningbo for more than 5 years were enrolled in the study. The subjects were surveyed by self-designed questionnaire and Pittsburgh sleep quality index (PSQI); PSQI > 7 was defined as the cut-off value for sleep quality. Data were analyzed by software SPSS 11.0. Results: The mean PSQI score was 5.79 ± 3.08 and 23.6% of perimenopausal women in the study showed poor sleep quality. The proportion of poor sleep in 55 - 60 age group was 40.2%, significantly higher than that of 40 - 44,45 - 49 and 50 - 54 age groups ( P <0. 05). The sleep quality was associated with physical exercise, social activity, sleep circumstance,anxiety and family income in perimenopausal women. Conclusion: The sleep quality of perimenopausal women and the influencing factors are associated with mental health, life style and sociol environment,which suggests that some interventions should be undertaken to improve the sleep quality of perimenopausal women.%目的:了解宁波地区围绝经期妇女的睡眠质量及影响因素.方法:采用匹兹堡睡眠质量指数量表(PSQI)及自制的围绝经期妇女睡眠质量影响因素调查表,对527名长期(5年以上)居住在宁波地区的围绝经期妇女进行问卷调查,资料采用SPSS 11.0软件进行统计分析,以PSQI>7分作为界值判断睡眠质量的好差.结果:本研究中495名围绝经期妇女的PSQI平均分为5.79±3.08,23.6%的围绝经期妇女睡眠质量较差.55~60岁组围绝经期妇女存在睡眠质量不好的比例为40.2%,明显高于40~44岁组、45~49岁组及50~54岁组(P<0.05);体育锻炼、社会活动、睡眠环境、思想顾虑以及家庭收入对睡眠有一定的影响.结论:围绝经期,尤其是55~60岁年龄段妇女睡眠质量相对较差,这与其生理和心理健康状况、生活习惯、社会环境

  18. Sex, women and the menopause: are specialist trainee doctors up for it? A survey of views and attitudes of specialist trainee doctors in Community Sexual & Reproductive Health and Obstetrics & Gynaecology around sexuality and sexual healthcare in the (peri)menopause.

    Science.gov (United States)

    Gleser, Heike

    2015-03-01

    Sexual health, function and pleasure can contribute significantly towards the wellbeing of (peri-)menopausal women. Healthcare professionals specialising in women's health should therefore be able to provide 'sex-positive' menopause care, which proactively addresses any sexual issues and assesses the need for contraception and prevention of sexually transmitted infections. A survey was used to investigate the views and attitudes of specialist trainee doctors in Community Sexual & Reproductive Health (cSRH) and Obstetrics & Gynaecology towards sexual health in the (peri)menopause as they play a key role in promoting the sexual wellbeing of their patients. The results showed that both study groups had positive attitudes towards sexuality and sexual healthcare of mid-life and older women. However, cSRH trainees had significantly more confidence in dealing with psychosexual problems and perceived significantly less barriers to deliver comprehensive menopausal care within the mostly community-based Sexual & Reproductive Healthcare settings they are working in compared to their mainly hospital-based gynaecological colleagues. Profiting from seemingly better training in the topic cSRH trainees also noticed considerably less embarrassment from their patients when addressing sexual issues. Nonetheless, training needs were identified in both trainee groups.

  19. The Association between Self-Reported Energy Intake and Intra-Abdominal Adipose Tissue in Perimenopausal Women

    Directory of Open Access Journals (Sweden)

    Rasa Kazlauskaite

    2012-01-01

    Full Text Available We have previously shown that physical activity predicts intra-abdominal adipose tissue (IAT, but it is unknown whether energy intake predicts IAT independently of physical activity in a community-based, naturalistic environment. The association of energy intake with IAT was explored cross-sectionally in women, recruited between 2002 and 2005 for a study of fat patterning in midlife. IAT at L4-L5 vertebral interspace was assessed by computed tomography, energy intake by the Block Food Frequency Questionnaire, and physical activity by the Kaiser Physical Activity Survey. Linear regression models were used for the principal analyses. Among the 257 women, 48% were African American and 52% were Caucasian. Women were 52±3 years old, and 49% were postmenopausal. Every 500 kcal increase in energy intake was associated with a 6% higher IAT (P=0.02, independent of physical activity (P=0.02, after adjustment for ethnicity, menopausal status, age, smoking, income, and DXA-assessed percent body fat. Energy intake had a significant interaction with ethnicity (P=0.02, but not with physical activity. Models using the IAT to subcutaneous abdominal adipose tissue ratio as an outcome had similar associations. In conclusion, self-reported EI was associated with preferential IAT accumulation in midlife women, independent of physical activity. This association was significantly stronger in Caucasian than African American women. Future longitudinal studies are needed to explore lifestyle predictors of IAT accumulation during the menopausal transition.

  20. Social impact and healthcare- seeking behavior for urinary incontinence among perimenopausal women attending gynae out patient department in BSMMU

    Directory of Open Access Journals (Sweden)

    Fahmida Zabin

    2016-07-01

    Full Text Available Background: Urinary incontinence (UI is a highly prevalent and burdensome condition among women.However,fewer than half of women with symptoms consult with a physician about incontinence, and determinant of treatment seeking are not well understood.Objectives: The aim of this study was to determine the prevalence, awareness and determinants of urinary incontinence (UI among women attending GOPD in BSMMU and the sociodemographic factors involved in their health care-seeking behaviour.Methods: Cross-sectional study was carried out in Gynaeout patient department of Bangabandhu Sheikh Mujib Medical University with a sample of 800 women aged 45 yrs and above.Results: A total of 1000 women were recruited for the study by purposive sampling,among them 800 agreed to participate and completed the questionnaire. Of these, 165 (20.6% were found to have UL Overall, the reason for not seeking medical attention was mainly embarrassment (40.6% at having to speak with doctor. Of the total study sample, 566 subjects (70.6% believed that UI was abnormal and worth reporting to a doctor. Coping mechanisms among incontinent women included frequent washing (58.3% and wearing a protective perineal pad (42.4%, changing underwear frequently (41.3%, decreasing fluid intake (19.8% and stopping all work (4.9%. Sufferers were most troubled by their inability to pray (64% maintain marital relationship (47%, limitation of their social activities (20%, difficulty in doing housework (14% and inconven­ience during shopping (13%. Most (56% found it most embarrassing to discuss UI with their husbands. The majority of women (51.9% believed child birth to be the major cause ofUI, followed by ageing (49.5%, menopause (34.2% and paralysis (25.3%. Most of the subjects (62.3% believe that UI can cause infection, some (20.5% believe that it can cause skin allergy and very few think that it can cause cancer or other disorders.Conclusions: Our findings indicate that although UI is

  1. Relation between mental status and sleep quality in perimenopausal women%围绝经期妇女心理状况与睡眠质量的相关性研究

    Institute of Scientific and Technical Information of China (English)

    王洪军; 王丽娜

    2013-01-01

    目的 探讨围绝经期妇女心理状况与睡眠质量的相关性.方法 选取2011年1月至2012年12月就诊于山东省精神卫生中心门诊的601例有睡眠障碍主诉的45~55岁围绝经期女性患者作为研究对象,利用自拟问卷、匹兹堡睡眠质量指数(PSQI)量表和症状自评量表(SCL-90)对601例更年期妇女进行一般情况、睡眠质量及心理健康状况调查.结果 601例有睡眠障碍主诉的围绝经期妇女PSQI平均得分(6±4)分,其中27.8%(167/601)存在睡眠质量问题(PSQI总分>7).相关分析表明PSQI总分与SCL-90总分存在相关性(r =0.535,P<0.05).多因素回归分析提示,躯体化、抑郁、焦虑和偏执可能是影响就诊的围绝经期妇女睡眠质量的影响因素(t值分别为7.25,3.02,2.64,-3.39,均P<0.01).结论 就诊围绝经期妇女睡眠质量可能受心理健康状况影响.%Objective To investigate the relation between mental status and sleep quality in perimenopausal women,and to provide theoretical basis for further improving the sleep quality of perimenopausal women.Methods A total of 601 perimenopausal women (45 to 55 years old) in Shandong province were recruited in this study.The patients went to mental health counseling center of Shandong province from January 2011 to December 2012 for insomnia or sleep problems.Standardized questionnaires,including general information,pittsburgh sleep quality index (PSQI) and symptom checklist-90 (SCL-90) scale were administered by group investigation.Results The mean global PSQI score of the sample was (6 ±4).About 27.8% (167/601) of women sufferring from sleep disturbance was defined as a global PSQI score > 7.There were significant differences in scores of SCL-90 among groups classified by the scores of global PSQI.The scores of global PSQI and SCL-90 showed a positive correlation (r =0.535,P < 0.05).Multifactor regression analysis showed that somatization,depression,anxiety and paranoia could significantly

  2. Response rates to oestrogen treatment in perimenopausal women: 5-year data from the Danish Osteoporosis Prevention Study (DOPS)

    DEFF Research Database (Denmark)

    Rejnmark, Lars; Vestergaard, P; Tofteng, Charlotte

    2004-01-01

    OBJECTIVE: To characterise women with no response or with a good response to hormone replacement therapy (HRT), evaluated by change in bone mineral density (BMD). Design: Nested case-control study within a comprehensive cohort study. SUBJECTS AND METHODS: In the Danish Osteoporosis Prevention Study...

  3. The effect of outdoor fitness dance on the quality of life in perimenopausal period women%室外健身舞对围绝经期妇女生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    黄秀凤; 王丽萍; 郑奋; 刘琼玲

    2013-01-01

    目的 探讨室外健身舞对社区围绝经期妇女生活质量的影响.方法 选择105例围绝经期妇女,随机分为观察组(n=52)和对照组(n=53),对照组妇女随意自由活动,观察组同步实施室外健身舞运动.12个月后采用生存质量指数评定量表(SF-36QOL)分别对两组患者生活质量进行评分并记录.结果 观察组总体生活质量明显高于对照组(P<0.01).结论 室外健身舞运动可以从生理和心理两方面提高围绝经期妇女的生活质量.%Objective To explore the effect of outdoor fitness dance on the quality of life (QOL) of perimenopausal period.Methods Totaled of 105 cases of patients in perimenopausal period women were randomly divided into observation group (n =52) and control group (n =53).Outdoor fitness dance,conventional therapy and nursing care were carried out in observation group.Conventional therapy and nursing care were given to control group.QOL marks were compared between the two groups 12 months later.Results QOL in observation was significantly higher than that of control group (P < 0.01).Conclusions Outdoor fitness dance can improve life quality of patients in perimenopausal period both in physical and mental health aspects.

  4. Relative factors and symptoms of characteristics analysis of depression in perimenopausal women in our hospital%我院围绝经期妇女抑郁症状相关因素及症状群特征分析

    Institute of Scientific and Technical Information of China (English)

    李茜西; 傅锦坚; 吕德欣

    2015-01-01

    目的:通过对柳州市妇幼保健院(以下简称“我院”)围绝经期妇女健康人群及抑郁症状人群的临床研究,探讨其抑郁症状发生相关因素及躯体症状群特征。方法收集2012年1月~2013年7月就诊于我院40~60岁围绝经期妇女460例,调查内容包括患者一般情况及汉密尔顿抑郁量表(HAMD)、Greene围绝经期症状评定量表,分析围绝经期妇女抑郁症状发生相关因素及躯体症状群特征。结果①根据纳入标准,排除病例16例,共有444例围绝经期妇女纳入本研究。根据HAMD分为无抑郁症状组298例,可能抑郁症状组103例,肯定抑郁症状组43例,抑郁症状检出率为32.88%,肯定抑郁患者检出率为9.68%。②兴趣爱好的有无、家庭收入的高低及是否绝经均为影响柳州市围绝经期妇女抑郁症状的相关因素(P<0.05)。③三组间焦虑症状评分(心悸、易紧张、失眠、易激动、焦虑、不能集中精力)、抑郁症状评分(易疲乏、对工作失去乐趣、忧郁不开心、爱哭)、躯体症状评分(躯体压力、麻木或刺感、手脚感觉障碍、胸闷)、性评分(对性缺乏兴趣)等15项症状评分比较,差异有统计学意义(P<0.05)。结论应重视围绝经期妇女的精神卫生状态、生活习惯、社会支持管理,以提高围绝经期妇女的生活质量,降低其发生抑郁症状的危险性。%Objective To investigate the relative factors of depression and physical symptoms of characteristics, by the clinical study of healthy population and depression population of perimenopausal women in Maternal and Child Health Hospital of Liuzhou City ( "our hospital" for short). Methods 460 perimenopausal women aged 40-60 years admitted to our hospital from January 2012 to July 2013 were collected. The research content included the general conditions of patients, HAMD, Greene perimenopausal symptoms rating scale. The relative factors of depression and

  5. Pelvic inflammatory diseases in perimenopause and menopause

    Directory of Open Access Journals (Sweden)

    Cabunac Petar

    2012-03-01

    Full Text Available Introduction: In the gynecological profession Pelvic Inflammatory Disease (PID has a significant role due to its frequency, many complications and high costs of treatment Aim: The aim of this study was to investigate frequency and complications caused by these diseases, and used methods of treatment. Methods: The research was conducted in Clinic of Obstetrics and Gynecology 'Narodni Front', Belgrade, and included all consecutive patients diagnosed with PID during the period from year 2007 to 2010. The diagnosis of PID was set on the basis of: gynecological examination, test analysis (leucocytes, sedimentation, platelets, CRP, CA125, and ultrasound examination. A clinical criterion is divided into minimal and additional. The study included 112 patients. There were 33.93% of women in perimenopause/menopause (experimental group, while the control group consisted of 66.07% female subjects. Results: The frequency of surgically treated patients in experimental and control group was: 44.74% : 39.19% (χ2 test; p > 0.05. Women in experimental group used Intrauterine Device (IUD more than other patients 57.89% : 13.15% (χ2 test; p = 0.0001. A link was established between the use of intrauterine devicela in (χ2 test; p = 0.0516, patients’ irregular control of IUD (χ2 test; p = 0.0114 and surgical treatments of women in experimental group. The conservative treatment usually applies dual antibiotic therapy. Costs of surgically treated patients are around 1300 and conservatively treated around 210 €. Conclusion: Women in perimenopause and menopause are not exposed to higher risks of contracting PID. Women in perimenopause and menopause which use intrauterine device and don’t have regular controls, have higher risk of surgical treatments in case of pelvic inflammatory disease. Costs of treatment are 6-7 times in lower with conservatively treated patients compared to operatively treated ones.

  6. A measurement-specific quality-of-life satisfaction during premenopause, perimenopause and postmenopause in Arabian Qatari women

    Directory of Open Access Journals (Sweden)

    Abdulbari Bener

    2014-01-01

    Full Text Available Objective: The aim of this study was to use an instrument, the menopause-specific quality-of-life satisfaction in the state of Qatar for the premenopausal, menopause and postmenopausal period.Design: A cross-sectional descriptive study was used to generate menopause symptoms experienced by Arabian Gulf women. Measurement-specific quality-of-life satisfaction questionnaires and face-to-face interviews were performed.Setting: Primary Health Care (PHC Centers in Qatar.Materials and Methods: A multistage sampling design was used and a representative sample of 1,500 women aged 40-60 years were included during July 2012 and November 2013, and 1,158 women agreed to participate (77.2% and responded to the study.Results: The mean age and standard deviation of the subjects was 50.9 ± 6.1. The median age of natural menopause in the present study was 49 years [mean and standard deviation 49.9 ± 2.7]. The rate of consanguineous marriages in the sample was found to be 30.3%. There were statistically significance differences between menopausal stages with regard to ethnicity, education level, occupation, type of housing condition, and consanguinity. There were statistically significance differences between menopausal stages concerning BMI groups, Systolic BP, Diastolic BP, physical activity, parity, and sheesha smoking habits. Meanwhile, the present study revealed that the most common disease was found to be diabetes mellitus (11.4%, followed by hypertension (6.6%, asthma (5.6% and CHD (2.5%, and the majority of subjects (69.5% had no specific disease. The most frequent symptom was "aches in the back and neck" (49.2%, night sweat (37.2%, low backache (35.7%, feeling nervous (35.4% followed by "aches in the muscles/joints" (34.6%, hot flashes (33.3%, decreased social activities (28.3%, decreased leisure activities (47.6%, difficulty sleeping (28.9%, mood swings (25.4%, and decreased concentration (28.3%, sexual activity (24.1% and total energy level (26

  7. 农村围绝经期女性血管舒缩症状影响因素的研究%Factors influencing the vasomotor symptoms in peri-menopausal women living in rural areas

    Institute of Scientific and Technical Information of China (English)

    臧洪艳; 姚应水; 贺连平; 聂淼; 葛建芬; 鲍丹凤; 康耀文; 陈燕; 黄志伟; 祁秦

    2012-01-01

    Objective:To investigate the risk factors influencing the vasomotor symptoms in women in rural areas during their menopausal transition. Methods: Standard questionnaire was performed in 743 peri-menopausal women(age range from 40 to 60) from rural areas. Results: 22.6% women experienced hot flushes during peri-menopause transition. Multiple logistic regress analysis showed that the risk factors were associated with sleep disturbance, irregular menstruation or premature menopause and anxiety. Conclusion: The prevalence of vasomotor symptoms appears lower in women living in rural areas. Transition to menstrual disorder may indicate the high prevalence of vasomotor symptoms that are frequently seen in women with poor sleeping and anxiety.%目的:研究我国农村围绝经期女性发生血管舒缩症状的危险因素.方法:采用标准化问卷对743名40~60岁的农村女性进行调查.结果:农村女性潮热出汗症状发生率为22.6%.经多因素Logistic回归分析,睡眠不好、月经不正常或绝经、有焦虑症状是发生血管舒缩症状的危险因素.结论:我国农村女性的血管舒缩症状发生率较低.女性从月经不正常时起即进入血管舒缩症状的高发时期,睡眠差和有焦虑症状的女性易发生潮热出汗症状.

  8. 上海社区内更年期妇女焦虑现况调查%Investigation on the current situation of anxiety in perimenopausal women in communities of Shanghai

    Institute of Scientific and Technical Information of China (English)

    顾磊; 杜莉; 施红; 钱晓敏; 谭晶; 秦敏; 纪若思; 沈谦; 朱丽萍

    2012-01-01

    目的:探讨上海市部分城区更年期妇女焦虑症状发生现况及其影响因素.方法:采用一般情况调查表.改良更年期Kupperman评分量表、社会支持评定量表、广泛性焦虑障碍量表,于2010年12月~2011年2月在上海某社区内对935名参加普查的45 ~59岁妇女进行调查.结果:焦虑症状呈现率14.1%.与焦虑症状发生有关的影响因素包括:户籍、1年内子女升学或就业失败、头痛、心悸、皮肤蚁走感、更年期综合征、主观支持评分等.结论:上海市更年期妇女焦虑症状呈现率较高,与多种社会、心理、生物学因素有关.医务工作者需采取有效措施完善更年期心理保健.%Objective; To explore the current situation and effect factors of anxiety among perimenopausal women in partia: urban areas in Shanghai. Methods: General condition questionnaire, modified menopausal Kupperman assessment scale, social support rating scale (SSRS), and generalized anxiety disorder 7 -item scale (GAD -7) were used to survey 935 women aged 45 ~59 years old who received general investigation in a community in Shanghai from December 2010 to February 2011. Results: The incidence of anxiety was 14.1%. The effect factors of anxiety in perimenopausal women included census registration, entering a higher school or employment failure of their children within one year, headache, palpitation, skin formication, menopausal syndrome, and subjective support score, and so on. Conciusion: The incidence of anxiety among perimenopausal women is high. It is associated with a variety of social, psychological and biological factors. The medical workers should take effective measures to perfect menopausal mental health.

  9. Caracterización de mujeres en etapa climatérica en Brisas del Golfo, República Bolivariana de Venezuela (2005-2007 Characterization of perimenopause women in Brisas del Golfo, Bolivarian Republic of Venezuela (2005-2007

    Directory of Open Access Journals (Sweden)

    María Isabel Capote Bueno

    2012-06-01

    Full Text Available Introducción: el climaterio es la etapa que comprende casi un tercio de la vida femenina y demanda en las mujeres una atención integral en salud. Objetivo: caracterizar a las mujeres en la etapa climatérica, del consultorio Brisas del Golfo. Métodos: se realizó un estudio descriptivo, el universo estuvo constituido por las 256 mujeres del consultorio Brisas del Golfo, en edades comprendidas entre los 45 y 59 años de edad, al que se le realizó un muestreo intencional y quedó la muestra constituida por 80 mujeres. Para la recolección de la información se aplicó una encuesta elaborada por la autora. Resultados: el 45 % de las mujeres eran casadas, incorporadas al trabajo fuera del hogar en un 56,2 %. Se encontraban en la etapa de la perimenopausia 45 (56,3 %, el hábito tóxico que primó fue el café 35 (77,7 %. Evaluaron la dinámica laboral y familiar de regular 15 (18,8 %. No estaban protegidas por algún método contraceptivo 36 (45 % de las mujeres y prevalecieron los síntomas vasomotores y psicológicos, dentro de estos: el calor, la ansiedad y el insomnio en un 52,5 %, 38,8 % y 36,3 %, respectivamente. Conclusiones: predominaron las mujeres con la secundaria terminada, con relaciones de pareja estables, y vinculadas laboralmente, con buena situación económica. Hubo alta incidencia de hábitos tóxicos con predominio del café. La mayoría no estaban controladas con métodos anticonceptivos. La dinámica de las relaciones fue buena y con mayor incidencia de síntomas vasomotores en la etapa perimenopáusica.Introduction: the perimenopause is the phase that comprises almost one third of female life in women and it demands comprehensive health care for women. Objective: to describe women in perimenopause at Brisas del Golfo clinic. Methods: we performed a descriptive study. The universe was 256 women in Brisas del Golfo clinic, who aged between 45 and 59 years old. They had undergone a purposive sample and the sample was made up

  10. 围绝经期子宫异常出血子宫内膜病理变化分析%Pathology of the endometrium in perimenopausal women with abnormal uterine bleeding

    Institute of Scientific and Technical Information of China (English)

    雷亚平; 胡雪涛

    2015-01-01

    Objective: To investigate the pathologic features of endometrium in perimenopausal women with abnormal uterine bleeding. Methods: The pathologic data of endometrium in 152 perimenopausal women with abnormal uterine bleeding were retrospectively analyzed. Results:Among 152 cases,the hyperplasis endometria in 74 cases(48. 68% ),proliferated phase of endometria in 48 cases(31. 58% ),secretory endometria in 18 cases(11. 84% ),hormone therapy endometria in 2 cases(1. 32% ),endometrial polyps in 7 cases( 4. 61% ),local endometrial cancer in 1 case(0. 66% ) and incomplete abortion in 2 cases(1. 32% ) were identified. Conclusions:Hyperplasis is the most common cause of the abnormal uterine bleeding in perimenopausal women, thereby the pathological diagnosis of endometrium should be noted.%目的::探讨围绝经期子宫异常出血患者的子宫内膜病理变化。方法:回顾性分析152例子宫异常出血患者诊刮子宫内膜的组织病理学资料。结果:152例子宫内膜中,增生性改变74例(48.68%),子宫内膜增殖期48例(31.58%),子宫内膜分泌期18例(11.84%),激素治疗后反应 2例(1.32%),子宫内膜息肉7例(4.61%),局灶癌变1例(0.66%),不全流产 2例(1.32%)。结论:子宫内膜增生性改变是围绝经期子宫异常出血最常见的原因之一,故应重视围绝经期子宫异常出血诊刮子宫内膜的病理诊断。

  11. Women, motherhood and early childhood

    DEFF Research Database (Denmark)

    Ravnbøl, Camilla Ida

    This paper explores the question of how Roma women’s situation influences Roma children’s survival, growth and development in the early years. It focuses specifically on the barriers and opportunities for action that Roma women experience and how these influence their possibilities to engage...... in efforts for their young children. The paper adopts the perspective that in poor and socially excluded Roma communities, young children’s survival, growth and development cannot be addressed effectively if the rights of women are overlooked. Roma women navigate in contexts where they, as women, experience...... an assessment of the mothers’ capacity to internalize and act upon advice. It is argued that supporting Roma women’s access to human rights is likely to have positive outcomes for the women and their families, especially the young children...

  12. 围绝经期女性情绪障碍影响因素的综合探讨%Comprehensive investigation of influencing factors for women emotional disorder during perimenopause

    Institute of Scientific and Technical Information of China (English)

    吴小立; 韩自力; 钟智勇; 张晋碚; 王相兰

    2011-01-01

    AIM: To explore the causes of women emotional disorder in perimenopause. METHODS: Sixty two perimenopausal women with emotional disorder screened by Zung self - rating anxiety scale ( SAS ) and Zung self - rating depression scale ( SDS ) were selected as case group, and they were admitted to the psychological ward to accept observation and therapy in The Third Affiliated Hospital of Sun Yat - sen University. Sixty healthy perimenopausal women without emotional disorder, from the hospital staffs and neighboring unit, also screened by SAS and SDS, were enrolled into control group. Every woman must accept the assessment of the rating scales[ including Hamilton anxiety scale ( HAMA ),Hamilton depression scale ( HAMD ), Eysenck personality questionnaire ( EPQ ), lift event scale ( LES ) and coping style questionnaire ] one time after registration. The peripheral venous blood samples at 8 o'clock AM were collected for detection of estradiol ( E2 ), serotonin ( 5 - HT ) and norepinephrine( NE ). RESULTS: Significant differences between case group and control group were observed in negative life events, EPQ, coping style and the concentration of E2 and 5 - HT. Multiple stepwise regression analysis of the information from case group indicated that the levels of 5 - HT, NE and E2 showed to be negatively correlated with HAMD total score, and negatively life event, reproachment, nervousness appeared to be positively correlated with HAMD total score. CONCLUSION: Women emotional disorders in perimenopause are the comprehensive result of multiple social - psychological factors and biological factors.%目的:系统探讨女性围绝经期情绪障碍的影响因素.方法:62例经Zung氏焦虑自评量表(SAS)、Zung氏抑郁自评量表(SDS)筛选后具有抑郁和/或焦虑(SAS>50和/或SDS>53)的围绝经期女性患者构成病例组,入组患者均在中山大学附属第三医院心理科病房接受住院观察和治疗;60例SAS<50和SDS<53的围绝经期健康女

  13. INFLUENCING OF FAMILY AFFECTION ON MENOPAUSAL SYMPTOMS AND DEPRESSION OF PERIMENOPAUSE PERIOD OF RURAL AREAS WOMEN%婚姻家庭对农村妇女围绝经期综合症及抑郁的影响

    Institute of Scientific and Technical Information of China (English)

    赵晓军; 陈长香; 付丽; 马素慧; 岳静玲

    2011-01-01

    [Objective] To understand Symptoms of menopausal and depression and their influencing factors of rural areas women in their perimenopause period, so as to provide countermeasures. [Methods] With stratified random sampling, aged 45-55 years were selected from Heilongjiang, Hebei, shan'xi, Shanxi and Henan province. Basic information questionnaire, Kupperm an score sheet, self-rating depress ion scale (SDS) and AGAR were adopted. [Results] Among the 884 subjects, 41.18% of them had depression. 15.05% of them were suspected to have depression, and 26.13% of them were diagnosed with depression. 79.30% reported premenopausal syndromes The rate of depression in women with long-time work and high pressures, poor quality of marriage, illness partner, divorced, low family income, big children burden; , addicted to cigarette or alcohol, bland diet and poor sleeping quality was higher than that of Perimenopausal Women (P < 0.05 or P < 0.01) . The women with perimenopausal syndrome had significant higher rate of depression. [Conclusion] The incidence of menopausal symptoms and perimenopausal depression were higher and the influencing factors were complex, the problems should to be attach importance of interstitial texture.%[目的]了解农村妇女围绝经期综合症、抑郁症状及其影响因素,为采取应对措施提供依据. [方法]2010年1~3月选取黑龙江,河北,陕西,山西,河南5省45 ~55岁妇女,采用自编一般情况调查表、更年期Kupperman评分量表、抑郁评分量表(CES - D)进行调查. [结果]884名调查对象中,抑郁总发生率为41.18%,可疑抑郁者15.05%,肯定抑郁者26.13%;围绝经期综合征发生率为79.30%;婚姻质量差、伴侣患病、离异、全家经济收入低、子女负担重者等发生围绝经期抑郁症的频率或程度高,差异有统计学意义(P< 0.05或P<0.01);且围绝经期综合征程度超重,抑郁发生率越高,差异有统计学意义(P<0.01).[结论]农村妇女

  14. Women, motherhood and early childhood

    DEFF Research Database (Denmark)

    Ravnbøl, Camilla Ida

    This paper explores the question of how Roma women’s situation influences Roma children’s survival, growth and development in the early years. It focuses specifically on the barriers and opportunities for action that Roma women experience and how these influence their possibilities to engage...... in efforts for their young children. The paper adopts the perspective that in poor and socially excluded Roma communities, young children’s survival, growth and development cannot be addressed effectively if the rights of women are overlooked. Roma women navigate in contexts where they, as women, experience...... multiple barriers to their agency in particular due to multiple forms of discrimination and living in poverty on the margins of society. In such contexts of disempowerment, programme responses are likely to meet with limited success if they seek to teach mothers about child care and rearing, without...

  15. Investigation of perimenopausal symptoms of middle-aged women in Xuhui region of Shanghai%上海徐汇区中年妇女围绝经期症状调查

    Institute of Scientific and Technical Information of China (English)

    朱晓璐; 李萍; 孙东梅; 陶敏芳; 滕银成

    2016-01-01

    Objective To discuss the occurrence and influencing factors of perimenopaual symptoms by investigating the perimenopausal symptoms in middle-aged women in Xuhui Region of Shanghai .Methods From August 1, 2012 to December 31, 2013, women aged 40-60 years taking health examination in Shanghai Jiaotong University Affiliated Sixth People ’ s Hospital were investigated .Modified Kupperman Index ( KMI) and general questionnaires were used to do the investigation and the data was analyzed .Results A total of 2 046 women were recruited in the investigation with mean age of 51.23 ±7.00 years.The occurrence of perimenopausal syndrome was 66.9%( KMI>6) .The occurrence rate of perimenopausal syndrome increased with the growth of age and menopausal status .The most common symptoms were fatigue (83.38%), dyspareunia (55.67%), bone pain (50.29%), insomnia (48.29%) and mood swing (40.71%) in order.Regression analysis revealed that growth of age , poor education, low income, late menarche, frequent induced abortion and complicating coronary heart disease were the risk factors of perimenopausal symptom aggravation (t value was 22.533, -4.055, -2.088, 2.709, 5.522 and 4.203, respectively, all P<0.05).Conclusion The occurrence of pe-rimenopausal symptoms in middle-aged women in Xuhui Region of Shanghai is high .Therefore, health and medical institutions should take more health care measures based on perimenopausal symptoms in Shanghai middle-aged women .%目的:通过对上海徐汇区中年妇女围绝经期症状的调查,探讨上海中年妇女围绝经期症状发生情况及其影响因素。方法采用改良Kupperman评分量表( KMI)及一般情况调查表对2012年8月1日至2013年12月31日在上海交通大学附属第六人民医院体检中心进行正常体检的年龄在40~60岁的中年妇女进行问卷调查,并分析调查结果。结果本次研究中,共纳入符合标准的妇女2046例。受试者平均年龄51.23±7.00岁。中年妇女

  16. Bone mineral content in the spongiosa of the lumbar spine of healthy perimenopausal women measured by QCT. Normal values and their relationship to mechanical stress of the vertebral column

    Energy Technology Data Exchange (ETDEWEB)

    Montag, M.; Meyer-Galander, H.M.; Peters, P.E.; Doeren, M.; Montag, T.

    1988-04-01

    Healthy perimenopausal women (152) were examined by QCT to quantify the mineral content of the axial skeleton. The density was measured in the spongiosa of the L 2-4, using single energy technique and the Cann-Genant calibration phantom. The women, aged 37 to 64, had no history of pathological fractures, ovariectomy, metabolic disease, or hormone therapy. The age-related mean values were 25 mg K2HP04cm/sup 3/ lower than the normal values reported by Genant et al. for 203 healthy American women. The 95% confidence interval was distinctly narrower (+-40 mgcm/sup 3/) than the American confidence interval (+-60 mgcm/sup 3/). To evaluate the relationship of the BMC to mechanical stress, the BMC was compared with body weight, body mass index (weightheight/sup 2/), and the lumbar muscle mass was estimated from cross sections of the paravertebral muscles in the CT images. The assumption that higher mechanical stress results in higher bone mineralization could not be confirmed.

  17. The Effect of Health Management On Psychological Status and Quality of Life of Perimenopausal Women%健康管理对围绝经期女性心理状况及生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    白琳; 张洛英; 闫培霞; 许晓峰

    2015-01-01

    目的:探讨健康管理对围绝经期女性心理状况和生活质量的影响。方法:将280例围绝经期患者分为进行健康管理的研究组146例和对照组134例,随访时间为6个月。采用症状自评量表(SCL-90)、抑郁自评量表(SDS)、焦虑自评量表(SAS)、生存质量测定简表(WHOQOL-BREF)进行评定。结果:280例围绝经期患者抑郁症状的发生率为29.6﹪,焦虑症状的发生率为33.2﹪,均以轻度为主。6个月时,研究组患者围绝经期相关知识知晓率为97.3%,明显高于对照组41.8%(P<0.01);研究组SCL-90、SDS、SAS评分(144.36±32.12,32.21±18.11,34.36±19.21)明显低于对照组(173.61±30.58,41.27±18.41,43.67±17.49)(均P<0.05);两组在生理、心理、社会、环境各领域及总的生存质量评分均较研究前有提高(均P<0.05),其中研究组提高程度更为显著(P<0.05)。结论:抑郁和焦虑是围绝经期常见的情绪表现,健康管理可以明显改善围绝经期女性的心理状况,提高其生活质量。%Objective: To evaluate the effect of health management on psychological ststus and quality of Life of perimenopausal women. Methods: 280 perimenopause women for health management were divided in research group(n=146) and control group (n=134), the follow-up time was 6 months. All the patients were studied and tested by using Symptom Checklist 90(SCL-90), Self-rating Depression Scale (SDS), Self-rating Anxiety Scale (SAS) and World Health Organization Quality of Life Assessment (WHOQOL-BREF). Results: In these women the incidence of depression was 29.6 ﹪ and of anxiety was 33.2 ﹪, all of these symptoms were mild. At the sixth month, the awareness rate of correlation knowledge of perimenopausal syndrome in the research group(97.3﹪) was markedly higher than that in the control group (41.8﹪) (P<0.01); The scale of SCL-90, SDS, SAS in research group (144.36±32

  18. The Analysis of the Application of Comprehensive Nursing Intervention in Women with Perimenopausal Syndrome%综合护理干预在围绝经期综合征妇女中的应用分析

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      目的:研究综合护理干预在围绝经期综合征妇女中的应用。方法:采用综合护理干预的方法加强对围绝经期综合征女性的护理干预,包括饮食指导、心理护理、健康指导等,比较护理干预前后患者的 Kupperman 评分、焦虑自评量表(SAS)及抑郁自评量表(SDS)评分情况。结果:护理干预后患者的 Kupperman 评分低于护理干预前,差异有统计学意义(P<0.05);护理干预后 SAS 和 SDS 评分均低于护理干预前,差异有统计学意义(P<0.05)。结论:综合护理干预能有效的减轻围绝经期综合征女性的临床症状,减轻焦虑等不良情绪,提高患者的生活质量。%Objective:To study the application of comprehensive nursing intervention in women with perimenopausal syndrome. Method:The comprehensive nursing intervention was taken to strengthen the perimenopausal syndrome nursing intervention for women,including diet,psychological nursing,health guidance,etc. The nursing intervention patients Kupperman score,self rating anxiety scale(SAS)and depression self rating scale (SDS)score before and after nursing were compared. Result:The Kupperman score after the nursing intervention in patients was less than before nursing intervention,compared before and after the intervention,and there was statistically significant difference(P<0.05). The SAS and SDS scores after nursing intervention were less than before nursing intervention,compared before and after the intervention,and there was statistically significant difference(P<0.05).Conclusion:Comprehensive nursing intervention can effectively relieve clinical symptoms of menopausal syndrome women,relieve anxiety and other negative emotions,improre the life quality of patients.

  19. Possible risk for gestational trophoblastic neoplasm in perimenopause and menopause

    Directory of Open Access Journals (Sweden)

    Nikolić Branka

    2011-01-01

    Full Text Available Gestational Trophoblastic Neoplasms (GTN are group of diseases which are known as fertilization disorders and may appear as Complete hydatidiform mole, Mole partialis, Invasive mole, Placental site trophoblastic tumor, Choriocarcinoma. Malignant disease precedes in approxi mately 50% of patients. All cases of GTN must be registrated. The Followe up programme period may last 6 months to 2 years until three sequential beta hCG values are negative. The risk of repeated GTN is low but patient has to be informed that risk is 1 : 74. GTN can appear in perimenopausal or menopausal women. That is the reason why each rapid enlargement of uterus especially with uterine bleeding followed with multiple cystic formations (grape like cysts needs a serious examination on GTN. Patient can complain of nausea, vomiting, painful breasts or hiperthyoidism. Legal abortion can precede GTN in perimenopausal women. In the great number of women with GTN the last pregnancy was 5 or more than 5 years before GTN is diagnosed. During 5 year period from june 1999. till june 2004, 58 GTN cases were diagnosed on our Department. 7 women with confirmed GTN were in perimenopause or menopause. All cases were hystologicalu confirmed with clinical low clinical score. In 1999. (March-June unpowerishment Uranium was used during war in Former Yugoslavia. Potential effect on reproductive potential could be analyzed after collecting data from the whole territory of Serbia and Montenegro in next years. All GTN patients are clinically, laboratory and ultrasonographicaly examined and staged according to FIGO 2002. recommendations

  20. Relationship between dietary structure and perimenopausal syndrome in women of Tai'an city%泰安市妇女膳食结构与围绝经期综合征关系

    Institute of Scientific and Technical Information of China (English)

    孙铮; 刘风云; 郝艳青; 张敏

    2012-01-01

    Objective To explore perimenopausal women' s dietary structure, the prevalence of menopause syndrome and its related factors. Methods Totally 862 female outpatients from 3 hospitals were selected. The patients were aged between 40 and 60 years, with uterus and one or two ovaries, and with menstrual changes or menopause syndrome symptoms. The menopausal symptoms were graded by improved Kupperman evaluation standard and the diet structure was evaluated with the standard of " The China Dietary Guidelines (2007) ". Results The menarche age of the perimenopausal women was 14. 8+1.9 years and the menostasis age was 49. 2 ±4. 8 years. There were 799(92. 69% ) patients having one or more menopause symptoms. Linear correlation analyses showed that improved Kupperman symptom score was correlated with menopause syndrome score. The dietary structure of the patients was not consistent with the recommended value of the Chinese balanced diet guide. Conclusion Most of the perimenopausal women' s dietary structure was not rational. The relationship between dietary behavior and menopausal symptoms needs further research.%目的 探讨围绝经期妇女膳食结构、绝经综合征发生率及相关因素.方法 抽取就诊于山东省泰安市3家医院妇科门诊、年龄40~ 60岁、有子宫及一侧或双侧卵巢、有月经改变或有绝经期综合征表现的862名妇女为调查对象,采用自制调查表进行调查,使用改良Kupperman评分标准进行绝经症状评分,与《中国居民膳食指南(2007)》(以下简称《指南》)的标准相比较.结果 月经情况:初潮年龄为(14.8±1.9)岁,绝经年龄为(49.2±4.8)岁;799人出现了≥1种绝经症状,占92.69%;Kupperman症状评分与绝经综合征症状得分直线相关分析结果均有相关性(P<0.05);围绝经期妇女膳食结构与《指南》相应项目比较,均不符合中国居民平衡膳食宝塔建议的推荐值.结论 围绝经期妇女膳食结构不够合理,围绝经期

  1. Influence of Yoga on perimenopausal disturbance of middle-aged women%瑜伽运动对中年妇女更年期症状困扰的影响

    Institute of Scientific and Technical Information of China (English)

    戴玉琴; 周志红; 段功香

    2013-01-01

    目的 探讨瑜伽运动对中年妇女更年期症状困扰的影响,为社区居民开展健康促进活动提供参考依据.方法 采用随机数字表法将株洲市芦淞区80名社区中年妇女分为瑜伽组40名和对照组40名,瑜伽组给予为期16周规范的瑜伽运动训练,对照组维持原生活方式不变.采用更年期症状困扰量表对两组中年女性进行问卷调查,并监测血压、腰围、体质量、体重指数、肌力、平衡功能等生理指标.结果 运动干预16周后,瑜伽组更年期症状困扰总分为(49.00±9.290)分,对照组为(70.50±17.304)分,差异有统计学意义(t=-4.896,P=0.014).除泌尿系统症状维度外,心血管及自主神经症状、骨关节症状、生殖系统症状、心理精神症状各维度得分两组比较,差异均有统计学意义(t值分别为-2.706,-2.013,-2.535,-7.610;P <0.05).瑜伽组中年女性血压、腰围、体质量、体重指数、肌力、平衡功能等生理指标与对照组比较,差异亦有统计学意义(P<0.05).结论 瑜伽运动可以有效地改善中年妇女的更年期症状困扰状态,提升其生活质量.%Objective To explore the influence of Yoga on the perimenopausal disturbance of middleaged women so as to provide reference for carrying out health promotion programs in community.Methods Totals of 80 middle-aged women of the community in the Lusong of Zhuzhou were divided into Yoga group (n =40) and control group (n =40).The Yoga group received the exercise of Yoga at least sixteen weeks,while the control group kept their life style.And they were investigated with the perimenopausal disturbance symptoms,and physiological indexes such as blood pressure,waist line,body weight,body mass index,muscle tone,balance function were measured after 16 weeks of Yoga exercise.Results After sixteen weeks,except genital system,there were significant differences in total perimenopausal disturbance symptoms score [(49.00 ± 9.290) vs (70.50 ± 17

  2. Effects of mood disturbance on social function in perimenopausal women%围绝经期妇女情绪障碍对其社会功能的影响

    Institute of Scientific and Technical Information of China (English)

    丛晓银; 贺丹军; 杨宁波; 李勇; 吴玉琴; 王美莲; 吴洁; 王昊飞

    2011-01-01

    目的 探讨围绝经期妇女情绪障碍对其社会功能的影响.方法 随机选择2008年6月至2009年3月在江苏省人民医院心理科或者妇科门诊就诊的40~60岁妇女203例,平均年龄(48.13±4.91)岁,进行问卷调查.问卷内容包括一般资料、改良Kupperman绝经指数量表(KMI)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)、症状自评量表(SCL-90)、生活质量综合评定问卷(GQOLI-74)中的社会功能维度量表的评估.并根据诊断标准将人群分为4组:对照组、围绝经期综合征组(A组)、情绪障碍组(B组)、围绝经期综合征合并情绪障碍组(C组).对调查数据进行单因素方差分析、相关分析、多元逐步回归分析.结果 B组和C组的社会功能各个因子的评分值均显著低于对照组(P<0.05),而工作学习和业余爱好2个因子的评分值显著低于A组(P<0.05).A组与对照组之间在社会支持因子评分存在显著性差异[(13.47±2.88)分比(15.38±2.16)分,P<0.05].围绝经期症状中眩晕、疲乏、性生活改变、情绪波动、抑郁疑心、失眠与社会支持因子呈负相关,其中抑郁与社会支持相关最为明显(r=-0.452,P<0.001).逐步回归结果表明情绪障碍中抑郁、强迫症状、睡眠障碍是影响社会功能的主要因素.结论 围绝经期的情绪障碍可导致社会功能明显降低.%Objective To explore the effects of the mood disturbance on social function in perimenopausal women.Methods This was a cross-sectional study of 203 women aged 40 to 60 years (average 48.13 ± 4.91 years old) from Psychology and Gynecology Out-patient Clinic in Jiangsu Province People's Hospital.All subjects were assessed using KMI,HAMA, HAMD, SCL-90, social function domain of GQOLI-74, and were divided into 4 groups: the normal group ( n =44 ), the perimenopause syndrome group (Group A, n = 33 ), the mood disturbance group (Group B, n =52), and the perimenopause syndrome with mood

  3. 宫腔镜在诊断围绝经期异常子宫出血中的应用%The application of hysteroscopy in diagnosing abnormal uterine bleeding of perimenopausal women

    Institute of Scientific and Technical Information of China (English)

    陆静

    2011-01-01

    目的 探讨官腔镜检查在围绝经期异常子宫出血中的诊断价值.方法 回顾性分析经病理检查确诊的203例围绝经期异常子宫出血患者的临床资料,比较宫腔镜检查、B超和病理诊断的符合率.结果 官腔镜诊断子宫内膜息肉60例,子宫粘膜下肌瘤26例,子宫颈管内膜息肉23例,子宫颈管粘膜下肌瘤7例,子宫内膜增殖症19例,子宫内膜炎13例,子宫内膜癌4例,与病理诊断总的符合率为87.4%,B超诊断与病理诊断的符合率为57.5%.结论 官腔镜在直视下观察宫腔病变并定位取活检,使诊断更直接、更准确,是诊断围绝经期异常子宫出血的有效手段.%Objective To evaluate the value of hysteroscopy to diagnose abnormal uterine bleeding of perimenopausal women. Methods Retrospectively analyse 203 patients of abnormal uterine bleeding. The diagnostic coincident rate of hysterosco py and transvagianal uitrasonography were compared with pathological examination. Results 60 cases of endometrial polypus 、26 cases of submucous myoma 、23 cases of endometrial polypus in cervical canal 、7 cases of submucous myoma in cervical canal 、19 cases of endometrial hyperplasia 、13 cases ofcendometritis and 4 cases of endometrial carcinoma were diagnosed by hysteroscopy, with the coincident rate as 87.4% ;The coincident rate of transvagianal uitrasonography was 57. 5%. Conclusion The diseases in the uterine cavity can be observed and taken biopsy by hysteroscopy which makes the diagnosis more directly and correctly. Hyste roscopy is an effective method to diagnose abnormal uterine bleeding of perimenopausal women.

  4. 个性化认知行为疗法在中重度围绝经期症状女性患者中的应用效果%Effect of Personalized Cognitive Behavioral Therapy on Women with Moderate to Severe Perimenopausal Symptoms

    Institute of Scientific and Technical Information of China (English)

    钟凯; 康汉珍; 胡启彩; 曾祥华; 洪爱军; 汤惠茹

    2015-01-01

    目的:评价个性化认知行为疗法对中重度围绝经期症状女性患者的干预效果。方法2014年7—9月对纳入58例中重度围绝经期症状女性患者从知、信、行方面实施个性化认知行为疗法,比较其干预前后改良 Kupperman症状评分及围绝经期知信行调查问卷得分情况。结果经个性化认知行为疗法干预后,58例中重度围绝经期症状女性患者改良 Kupperman各项得分较干预前均有下降,其中潮热出汗、感觉异常、失眠、易激动、抑郁、眩晕、骨关节肌肉痛及性交痛与干预前比较差异有统计学意义(P<0.05);干预后知、信、行评分较干预前均明显升高(P<0.01)。结论个性化认知行为疗法可有效改善中重度围绝经期女性患者相关症状,提高其预防保健意识,形成正确的健康信念,从而最终转化为行之有效的预防保健行为。%Objective To assess the effect of personalized cognitive behavioral therapy on women with moderate to severe perimenopausal symptoms in terms of their perimenopausal symptoms and perimenopausal-related knowledge, attitude, and practice (KAP). Methods Women with moderate to severe perimenopausal symptoms were treated with personalized cognitive behavioral therapy from July to September 2014. Kupperman index and perimenopausal-related KAP questionnaire were applied for the effect of the therapy. Results After treatment, the score of each symptom in Kupperman index of 58 women were declined. And the score of hot flashes sweating, paresthesia, insomnia, irritability, depression, dizziness and joint muscle pain was significantly decreased ( P<0.05). Moreover, perimenopausal-related KAP scores were also increased significantly ( P<0.01). Conclusion Personalized cognitive behavioral therapy is effective for improving the symptoms of women with moderate to severe perimenopausal symptoms, enhancing their prevention and healthcare awareness so as to help

  5. 围绝经期女性患者住院期间焦虑抑郁情绪调查研究%Study on anxiety and depression of perimenopausal women during hospitalization

    Institute of Scientific and Technical Information of China (English)

    郑顺杰; 吴洁

    2013-01-01

    目的 探讨围绝经期女性患者焦虑抑郁情绪的检出率和影响因素.方法 采用自编问卷、抑郁自评量表(SDS)和焦虑自评量表(SAS)对2011年12月~2012年12月在浙江省金华市中心医院住院治疗的200例围绝经期女性患者进行测评,运用SPSS 18.0统计软件进行描述性统计和二分类Logistic回归分析,探讨围绝经期女性患者焦虑抑郁情绪检出率和影响因素,旨在为采取针对性的干预措施提供参考依据.结果 200例围绝经期女性患者中焦虑情绪检出率为20.50%(41/200),抑郁情绪检出率为22.50%(45/200).多因素Logistic回归分析显示,伴侣健康状况好是围绝经期女性患者住院期间焦虑情绪的保护因素(P<0.05),经济状况好是围绝经期女性患者住院期间抑郁情绪的保护因素(P<0.05),文化程度高和婚姻自我感觉好是围绝经期女性患者住院期间焦虑抑郁情绪的保护因素(P<0.05),患者年龄大和所患疾病为恶性是围绝经期女性患者住院期间焦虑、抑郁情绪的危险因素(P<0.05).结论 围绝经期女性患者抑郁焦虑情绪检出率较高,其发生影响因素众多.在对患者进行干预的过程中,应对高危人群进行重点干预,减少患者焦虑抑郁情绪的出现.%Objective To investigate anxiety and depression of perimenopausal women during hospitalization and its influence factors.Methods 200 perimenopausal women who were treated in Department of Obstetrics and Gynecology in the Central Hospital of Jinhua City in Zhejiang Province were surveyed by the self-rating anxiety scale (SAS) and self-rating depression scale (SDS).Then they were analyzed by descriptive statistics and binary classification Logistic regression analysis of SPSS 16.0,the detection rate of anxiety and depression of perimenopausal women and influence factors were discussed,in order to provide reference basis for targeted intervention measures.Results The overall prevalence of anxiety

  6. Hormone replacement therapy diminishes hearing in peri-menopausal mice.

    Science.gov (United States)

    Price, Katharine; Zhu, Xiaoxia; Guimaraes, Patricia F; Vasilyeva, Olga N; Frisina, Robert D

    2009-06-01

    We recently discovered that progestin in hormone replacement therapy (HRT) for post-menopausal women has detrimental effects on the ear and central auditory system [Guimaraes, P., Frisina, S.T., Mapes, F., Tadros, S.F., Frisina, D.R., Frisina, R.D., 2006. Progestin negatively affects hearing in aged women. Proc. Natl. Acad. Sci. - PNAS 103, 14246-14249]. To start determining the generality and neural bases of these human findings, the present study examined the effects of combination HRT (estrogen+progestin) and estrogen alone on hearing in peri-menopausal mice. Specifically, auditory brainstem responses (ABRs-sensitivity of the auditory system) and distortion-product otoacoustic emissions (DPOAEs-cochlear outer hair cell system) were employed. Middle age female CBA mice received either a time-release, subcutaneous implanted pellet of estrogen+progestin, estrogen alone, or placebo. Longitudinal comparisons of ABR threshold data obtained at 4 months of treatment revealed statistically significant declines in auditory sensitivity over time for the combined estrogen+progestin treatment group, with the estrogen only group revealing milder changes at 3, 6 and 32 kHz. DPOAE testing revealed statistically significant differences for the estrogen+progestin treatment group in the high and middle frequency ranges (15-29 and 30-45 kHz) after as early as 2 months of treatment (p<0.01 and p<0.001, respectively). Statistically significant changes were also seen at 4 months of treatment across all frequencies for the combined HRT group. These data suggest that estrogen+progestin HRT therapy of 4 months duration impairs outer hair cell functioning and overall auditory sensitivity. These findings indicate that estrogen+progestin HRT may actually accelerate age-related hearing loss, relative to estrogen monotherapy; findings that are consistent with the clinical hearing loss observed in aging women that have taken combination HRT.

  7. Circadian Rhythms of Melatonin Secretion in Peri- and Postmenopausal Women with Insomnia

    Directory of Open Access Journals (Sweden)

    Irina M. Madaeva

    2017-06-01

    Full Text Available The aim of this study was to assess complaints about sleep quality and to investigate circadian rhythms of melatonin secretion in peri- and postmenopausal women. Material and Methods: A total of 146 climacteric women were examined. All patients were divided into 2 groups: Group1 included 72 perimenopausal women and Group 2 included 74 postmenopausal women. Women were surveyed with special questionnaires: PSQI, FFS, ESS, Daytime Feeling and Functioning Scale. Insomnia Severity Index was calculated. Salivary melatonin content was determined (4 times a day by immunoassay using Microplate Reader EL×808 (USA. Results: Perimenopausal women often complained about difficulties falling asleep (more than 20 minutes from the moment the light was turned off and difficulties awakening in the morning, while postmenopausal women often complained about snoring and frequent awakenings during sleep(≥2 times. ISI was 21.3±0.54 in Group 1 and 24.8±0.31 in Group 2, which corresponded to insomnia. Daily melatonin secretion in perimenopausal patients with insomnia was altered – the maximal level was registered in the morning hours. The circadian rhythms of melatonin secretion in the group of postmenopausal women did not correlate to the occurrence of insomnia. Conclusion: We can recommend administration of melatonin in the evening time and light therapy in the early morning hours in the complex treatment of SDs in perimenopausal women for normalizing and shifting the chronobiological rhythms of melatonin secretion, and specific therapy is aimed to eliminate snoring for postmenopausal women.

  8. The analysis of bone mineral density and correlation of perimenopausal and post-perimenopausal women in university community%高校社区围绝经期、绝经后女性骨密度调查及相关因素分析

    Institute of Scientific and Technical Information of China (English)

    路军梅; 庄稼; 闫菡; 郭燕; 高路; 孙朝阳; 于学文

    2014-01-01

    目的:了解高校社区围绝经期、绝经后女性骨密度状况及影响因素,为骨质疏松症预防提供依据。方法:对西安某高校社区40~60岁女性进行身高、体重、腰围、臀围、前臂长测量,问卷调查年龄、月经情况,采用双能X线骨密度仪测量腕部、腰椎及髋部骨密度,进行统计学分析,并将骨密度结果与年龄、身高、体重、体重指数、腰围、臀围、前臂长、月经状况进行相关性分析。结果:167例中,各部位骨密度随年龄增加而降低,绝经后较围绝经期下降。骨密度与身高、体重、体质指数、腰围、臀围、前臂长呈正相关,与年龄、初潮年龄、是否绝经呈负相关。结论:绝经后女性骨密度下降,应改善生活习惯和加强体育锻炼,减少骨质疏松症的发生。%Objective:To master bone mineral density and correlation of perimenopausal and post‐perim‐enopausal women in university community ,to provide data for prevention osteoporosis .Methods:The age ,meno‐pause stations were inquired and height ,weight ,waistline ,hipline ,forearm length were metered in female from 40 to 60 in university community .The bone mineral density of wrist ,lumber ,hip were checked by dual x‐ray absorptiome‐try .The relationships were analyzed between BMD and age ,height ,weight ,BMI ,waistline ,hipline ,forearm length , menopause stations .Results :BMD decreased with age increasing .BMD of post‐menopause was lower than thats of menopause .There were positive correlations between BMD and height ,weight ,BMI ,waistline ,hipline ,forearm length ,but there were negative correlations between BMD and age ,menopause .Conclusions :BMD of post‐meno‐pause declined and they should improve the living habits and strengthen physical exercise to prevent OsteoPorosis .

  9. Consider prescribing OCs for perimenopause use.

    Science.gov (United States)

    2000-03-01

    Contraceptive experts advise the use of low-dose (20-35 mcg estrogen) oral contraceptives (OCs) for perimenopausal patients because of their numerous advantages over hormone replacement therapy. Benefits include effective contraception, regular menses, treatment of menorrhagia and dysmenorrhea, reduction of vasomotor symptoms, higher bone density and fewer fractures, and prevention of ovarian and endometrial cancers. Although age limits for OC use for healthy nonsmoking women have been lifted for some time, certain providers still hesitate to prescribe OCs. Moreover, epidemiological studies confirm that low-dose pills are safe for healthy, nonsmoking women with normal blood pressure. More definitive research also found that the increased risk was mainly related to smoking rather than age. Since smoking is an important risk factor in OC use, pill use by smokers over 35 years old is contraindicated. Instead, it is suggested that they use progestin-only pills, IUDs, or barrier contraceptives for birth control. Another research indicates that women who use the pill can decrease their risk of postmenopausal fractures.

  10. Contraception in perimenopause.

    Science.gov (United States)

    Taneepanichskul, Surasak; Dusitsin, Nikorn

    2003-06-01

    Women in their forties are still potentially fertile, and pregnancy in this age group is attended with increased maternal mortality, spontaneous abortion, fetal anomalies and perinatal mortality. Contraception for women in this age group has special risks and benefits; both should be balanced to choose between the different options available. Recent epidemiological and clinical pharmacology studies have indicated the safety of extending the use of combined oral contraceptives (COCs) beyond the age of 35 years and up to menopause. Women who have reasons for avoiding COCs can use progestogen-only contraceptives like pills, depot injectables and implants. Implant combines high efficacy and long-term effect. Both copper-releasing and levonorgestrel-releasing intrauterine contraceptive device (LNG-IUD) combine the advantages of high efficacy and long-term effect. The reduced fecundity above the age of forty can allow extending the use beyond the accepted term, and up to one or two years beyond the menopause without the need for replacement. The levonorgestrel IUD has the advantage of reducing the amount of menstrual bleeding. The condom has the added benefit of protection against sexual transmitted diseases (STDs). Male or female sterilization is an excellent contraceptive option, provided that this approach is culturally acceptable and available at reasonable cost and low risk.

  11. 三种方法治疗围绝经期女性情绪障碍的比较%Comparison of Three Kinds of Regimens Dealing with Women Emotional Disorder during Perimenopause

    Institute of Scientific and Technical Information of China (English)

    吴小立; 钟智勇; 韩自力; 王相兰

    2011-01-01

    [Objective]To explore the best regimen dealing with perimenopausal women emotional disorder.[Methods]Sixtytwo perimenopausal women with emotional disorder screened by SAS and SDS were randomly registered into three different groups (20 for paroxetine combined with psychological therapy, 21 for paroxetine combined with hormone replace treatment and psychological therapy, 21 for hormone replace treatment combined with psychological therapy), and they accepted four weeks,observation.Every patient accepted the assessment of these rating scales (including Greene, HAMA, HAMD) one time before and after treatment, and only one test for TESS after treatment.[Results]All regimens improved the score of Greene and HAMA, but there was no statistical difference between different regimens.HRT combined with psychological therapy did not effectively improve the score of HAMD, Both paroxetine combined with psychological therapy and paroxetine combined with HRT and psychological therapy improve the score of HAMD much more than HRT combined with psychological therapy (P=0.018).There is no significant difference of TESS score between different regimens (P = 0.08).[Conclusion]considering that latent, far-reaching serious disadvantages, the regimen of paroxetine combined with psychological therapy deserves to be advocated in our clinical practice.%[目的]探讨治疗女性围绝经期情绪障碍的合适方案.[方法]将经Zung氏焦虑自评量表(Zung Self-Rating Anxiety Scale/SAS)、Zung氏抑郁自评量表(Zung Self-Rating Depression Scale/SDS)筛选后具有抑郁和/或焦虑的围绝经期女性62例随机进入组1(帕罗西汀+心理治疗20例)、组2(帕罗西汀+心理+HRT(Hormone Replacement Treatment)治疗21例)和组3(HRT+心理治疗21例)治疗4周.所有患者在治疗前后均进行一次更年期症状主诉量表(Greene's Climacteric Scale)、汉密尔顿焦虑量表(Hamilton Anxiety Scale/HAMA)、汉密尔顿抑郁量表(Hamilton Depression Scale/HAMD)的评

  12. 星状神经节阻滞治疗围绝经期自主神经系统功能不稳定症状的疗效%Curative Effect of Stellate Ganglion Block on Function Disorders of Autonomic Nervous System in Perimenopause Women

    Institute of Scientific and Technical Information of China (English)

    王玲玲; 马杰; 张海泉; 张宝琴; 赵树华; 房丽

    2011-01-01

    目的 探讨星状神经节阻滞治疗围绝经期自主神经系统功能不稳定症状的疗效.方法 对30例主要表现自主神经系统功能不稳定症状如失眠、眩晕、心悸,皮肤感觉异常等的围绝经期患者.采用前入路星状神经节阻滞(Stellate Canglion Block,SGB)每日1次,左右交替进行,每10次为1个疗程,均治疗2个疗程.观察血中E2,FSH的水平及自主神经系统功能不稳定症状改善情况.结果 运用星状神经阻滞法治疗后,围绝经期患者自主神经系统功能不稳定症状明显改善,血中E2水平显著升高,FSH下降(P<0.05).结论 星状神经节阻滞可以治疗围绝经期自主神经系统功能不稳定,其症状明显缓解或消失.%[ Objective] To observe the curative effect of stellate ganglion block on function disorders of autonomic nervous system in perimenopause women. [ Methods ] 30 perimenopause women with function disorders of autonomic nervous system were collected, which the symptoms included insomnia, vertigo, palpitation and paresthesia. The patients were given anterior approach stellate ganglion block (SGB) once a day, alternating left and right, 10 times was one course, and all patients were treated for two courses. The levels of E2 and FSH in blood, and improvement of disorders symptoms of autonomic nervous system were observed. [ Results] After SGB treatment, symptoms of function disorders of autonomic nervous system in perimenopause women improved significantly, level of blood E2 increased significantly, whereas FSH level decreased (P < 0.05). [ Conclusion ] SGB has good effect on the function disorders of autonomic nervous system in perimenopause women, the symptoms are significantly alleviated or disappeared.

  13. Influence of nursing intervention on mood disorder and quality of life of perimenopausal women%护理干预对围绝经期女性情绪障碍及生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    黄文欢; 尹月娥; 贾玉娥

    2015-01-01

    目的:探讨优质综合护理干预对围绝经期女性情绪障碍及生活质量的影响。方法选择2011年2月~2014年6月在我院就诊的178例围绝经期情绪障碍患者,将其随机分为对照组和观察组,每组89例。对照组给予常规护理及健康知识教育指导,观察组实施优质综合护理干预。评价并比较两组的焦虑、抑郁情绪和生活质量状况。结果护理干预前,两组的焦虑自评量表(SAS)、抑郁自评量表(SDS)以及世界卫生组织生活质量测定量表(WHOQOL-100)评分差异无统计学意义(P跃0.05);护理干预后,两组的SAS和SDS评分均显著降低(P0.05).After nursing intervention,the scores of SAS and SDS in two groups was significantly decreased(P0.05). Conclusion Quality comprehensive nursing intervention can relieve or remove the mood disorder of perimenopausal women,help them live through menopause successfully and improve their quality of life.

  14. 不同术式对围绝经期女性子宫切除术后生活质量的影响%INFLUENCE ON QUALITY OF LIFE FOR PERIMENOPAUSAL WOMEN AFTER DIFFERENT OPERA-TIONS OF HYSTERECTOMY

    Institute of Scientific and Technical Information of China (English)

    王艳君

    2015-01-01

    目的:探讨不同术式对围绝经期女性子宫切除术后生活质量的影响。方法将96例行子宫切除术的围绝经期女性分为 A 组(子宫切除术)(n=41)、B 组(子宫+单侧卵巢切除术)(n=34)、C 组(子宫切除术+双侧卵巢切除术)(n=21),术前和术后6个月检测三组的激素水平,并采用改良 Kupperman 指数和女性性功能指数(FSFI)量表评价三组术后的围绝经期症状和性功能状况。结果三组术前的激素水平、Kupperman 和 FSFI 评分比较差异无统计学意义(P >0.05)。术后6个月,C 组的 FSH 和 LH 水平高于 A 组和 B 组(P 0.05),三组的 Kupperman 和 FSFI 评分比较差异有统计学意义(P 0.05).Postoperative 6 months,FSH and LH levels of group C were higher than those of group A and group B (P 0.05).Kupper-man and FSFI score of three groups were statistically significant (P < 0.05).Conclusion Keep bilateral or unilateral ovarian in hysterectomy of perimenopausal women can help to improve the quality of life.

  15. 广场舞对围绝经期妇女抑郁症状和生活质量的影响%Study on the Effect of Square Dance on Depression and Quality of Life of the Perimenopause Women

    Institute of Scientific and Technical Information of China (English)

    茆广绪; 刘丽; 谢红卫

    2016-01-01

    目的:探讨广场舞对围绝经期妇女抑郁症状和生活质量的改善情况。方法:选择衡阳市5个区542例围绝经期妇女(45~59岁),采用回顾性调查方法,将研究对象分为广场舞组(204人)和对照组(338人),广场舞组为参与广场舞蹈锻炼,3~4次/周,30~44min/次,持续6个月的围绝经期妇女,对照组为居住在相同社区内未参与体育锻炼的围绝经期妇女。采用Zung氏抑郁自评量表(SDS)和世界卫生组织生存质量测定简表(WHOQOL‐BREF)对两组人群进行评估。结果:与对照组相比,广场舞蹈锻炼组抑郁量表(SDS)各因子评分及总分均显著减少;生活质量量表(WHO‐QOL‐BREF)因子评分及总分则显著增加,差异均具有统计学意义(P<0.05)。并且两个量表相关维度间呈中度负相关,各症状及总分之间的相关有统计学意义(P<0.05)。结论:广场舞锻炼可有效缓解围绝经期妇女抑郁症状和提高其生活质量。%Objective:To explore the effect of square dance on depression and quality of life of the perimenopause women .Methods:542 perimenopause female (45~59 years old) were randomly divided into study (204 cases) and con‐trol groups (338 cases) ,the study group was participated in the square dance movement ,exercise intensity was 3~44times/week ,30~44min/time ,six months ,the control group consisted of same age living in the same district ,who didn’t take part in exercise .After enrollment ,these two groups received assessments of Zung’s Self‐Rating Depression Scale (SDS) and life quality scale of WHO(WHOQOL‐BREF) .Results:Compared with control group ,there were sig‐nificant increase in scores of all items and total score of SDS and WHOQOL‐BREF in dance exercises group(P<0 .05 all) .And the items and score of SDS ,correlated significantly with the score of WHOQOL‐BREF(P<0 .05) .Conclu‐sion:Square dance exercises may

  16. 围绝经期妇女焦虑、抑郁障碍的临床特征及影响因素分析%Clinical features of depression and anxiety disorders and their influence factors in perimenopausal women

    Institute of Scientific and Technical Information of China (English)

    郭珍; 刘飞; 张欣尚; 陆峥

    2015-01-01

    Objective To investigate the clinical features of depression and anxiety disorders and their influence factors in women during perimenopause .Methods Fifty-seven cases of first hospitalized perimenopausal patients with anxiety and depression symptoms evaluated by Hamilton Depression Rating Scale for Depression (HAMD) ,Hamilton Anxiety Scale for Anxiety (HAMA) and Life Event Scale (LES) ,and detected of hormone levels .All of the data were input into a database and analyzed with de‐scriptive statistics ,Spearman correlation analysis and multiple linear regression analysis .Results All 57 patients in the HAMD total score of (22 .56 ± 8 .48) ,HAMA total score of (15 .21 ± 7 .88) ,mainly mild or moderate depression and definite anxiety .Most of the patients affected by life events ,especial the negative life events .Linear correlation analysis showed that the incidence of postmenopausal was posi‐tively correlated with depressive disorder ,the correlation coefficient was 0 .275;there was no significant correlation factor with anxiety disorders .Linear regression analysis showed that estradiol was negatively correlation with depressive disorders;pituitary prolactin ,economically disadvantaged families ,children long - term leaving home was positively correlated with depression (the regression coefficients were-0 .823 ,0 .230 ,1 .017 ,0 .783 ,respectively);economically disadvantaged families ,bad marital relations was positively correlated with anxiety disorders (the regression coefficient were 0 .802 ,0 .553) .Conclu‐sions Perimenopausal women were mainly in mild or moderate anxiety and depression ,were affected by hormones and social family factors .%目的:探讨围绝经期妇女焦虑、抑郁障碍的主要临床特征及相关影响因素。方法采用HAMD和HAMA对57例首次入院治疗的围绝经期焦虑、抑郁障碍患者进行临床症状评估,生活事件量表(LES)评估,以及检测每位患者体内激素水平,并用描述性统

  17. Assessment of intake of calcium and vitamin D and sun exposure in the context of osteoporosis risk in a study conducted on perimenopausal women

    Directory of Open Access Journals (Sweden)

    Anna Kopiczko

    2014-05-01

    Full Text Available Introduction: The results of many epidemiological and clinical studies have shown that osteoporosis is a multifactorial disease and develops mainly in women during menopause. The aim of this study was to evaluate the diet with particular emphasis on calcium and vitamin D intake and sun exposure in premenopausal women in terms of risk of osteoporosis. Material and methods : The study involved 300 women aged 45-55 years from Warsaw. The method used was a questionnaire assessing the frequency of consumption from the last three months. Exposure to the sun evaluated using a questionnaire prepared in cooperation with the Institute of Food and Nutrition in Warsaw. For the purpose of the project, profiles of attitudes towards prevention of osteoporosis were developed. Results : Inadequate intake of calcium and vitamin D among the majority of women surveyed was confirmed. The highest percentage of women represented profile VIII: attitudes towards prevention of osteoporosis, characterized by insufficient exposure to sunlight and a diet deficient in both calcium and vitamin D. Conclusions: In the diets of women surveyed significant deficiencies of calcium and vitamin D were found, which confirms previous reports on the lack of nutritional support for normal women’s bone mineralization. Among the surveyed women the majority reported insufficient exposure to sunlight as a source of vitamin D additional to food. There is a need for health education of these women in the prevention of osteoporosis and especially paying attention to the proper intake of calcium and more vitamin D in their diet. At the same time, adequate exposure to the sun is vital as it is the main source of vitamin D for the body coming not from the food consumed.

  18. Menopause 101: A Primer for the Perimenopausal

    Science.gov (United States)

    ... in the News Press Room Assistance Society Overview Menopause 101: A primer for the perimenopausal The information ... about 2 years earlier. Common Body Changes at Menopause Each woman’s experience of menopause is different. Many ...

  19. [Evaluation of the effects of a natural dietary supplement with cranberry, Noxamicina® and D-mannose in recurrent urinary infections in perimenopausal women].

    Science.gov (United States)

    DE Leo, Vincenzo; Cappelli, Valentina; Massaro, Maria G; Tosti, Claudia; Morgante, Giuseppe

    2017-08-01

    The female genital apparatus, the urinary tract and the perineal supporting tissues share a common embryological origin, whose differentiation depends on the action of estrogens. In adult women, the progressive decline of the ovarian function, with the ensuing estrogen deprivation, reduces tissue tropism causing urogenital atrophy, which makes these organs much more susceptible to traumatisms and urinary infections. The disorders associated with changes in the urogenital tract of peri- and postmenopausal women have significant clinical relevance, both on account of their chronicity and high frequency of occurrence and on account of their having major repercussions on the quality of life of the women, who often have to call their doctor seeking relief for their symptoms. In general, these patients report having a significant number of episodes of cystitis per year. With a view to verifying whether the use of a new dietary supplement (Kistinox® Forte sachets) containing cranberry (Vaccinium macrocarpon), Noxamicina® (propolis extract) and D-mannose can be of use in the treatment of cystitis, with or without bacteriuria, through the elimination of urinary symptoms, a multicenter clinical study was conducted on 150 women aged 40 to 50 suffering from recurrent episodes of cystitis as attested by at least one positive urine culture during the six months preceding their recruitment. The subjects were randomly assigned to two groups: Group A: 100 women were given Kistinox® Forte, 1 sachet per day during the first 10 days of the month, for 3 months; Group B: 50 women did not receive any treatment to serve as a control group. The results of the present study show a complete remission of urinary symptoms in 92 women; a slight decrease in urinary symptoms was observed in 5 subjects, whereas 3 women who stopped the treatment after the first cycle were considered drop-outs. This multicenter clinical study revealed the excellent efficacy and tolerability of Kistinox® Forte

  20. [Impact of risk factors for osteoporosis on bone mineral density in perimenopausal women of the City of Querétaro, México].

    Science.gov (United States)

    Aguilera-Barreiro, María de los Angeles; Rivera-Márquez, José Alberto; Trujillo-Arriaga, Héctor Miguel; Ruiz-Acosta, Juan Manuel; Rodríguez-García, Mario Enrique

    2013-03-01

    It is essential to evaluate osteoporosis risk factors, mainly the modifiable, like the lifestyle, in Mexican women in order to prevent it, since it is a serious public health problem. We studied 805 women (35-55 years old) in the City of Queretaro, México. We obtained: personal data, family history, habits, such as smoking, alcohol, caffeine (coffee and soft drink of cola) and physical activity. Participants complete the questionnaire on 19 risk factors for osteoporosis (International Osteoporosis Foundation) one of them with risk. We evaluated: body mass index (BMI), cardiovascular risk and corporal complexion. Bone densitometry was performed in two diagnostic regions: lumbar spine and total hip and participants were classified as normal bone mass density (BMD), low BMD and osteoporosis. The prevalence of osteoporosis was 7% and of low BMD was 34%, predominantly in the lumbar region and in those with menopause. In osteoporotic women, the age was higher (51 years) and 85% menopausal women, also lower values of weight, height, BMI, waist circumference and hip than women with normal bone mass density. The significantly modifiable risk factors were: low weight, smoking and consumption of soft drink of cola with 6,5, 1,2 and 1,4 (odds ratio), respectively (p < 0.05). The significantly non-modifiable risk factors were: menopause (surgical), history of fracture and risk. It is concluded that within the modifiable risk factors for the prevention ofosteoporosis, those with the greatest impact were low weight, cigarette and soft drink of cola.

  1. Cost-effectiveness of an exercise intervention program in perimenopausal women : the Fitness League Against MENopause COst (FLAMENCO) randomized controlled trial

    NARCIS (Netherlands)

    Carbonell-Baeza, Ana; Soriano-Maldonado, Alberto; Gallo, Francisco Javier; López del Amo, María Puerto; Ruiz-Cabello, Pilar; Andrade, Ana; Borges-Cosic, Milkana; Peces-Rama, Antonio Rubén; Spacírová, Zuzana; Álvarez-Gallardo, Inmaculada C; García-Mochón, Leticia; Segura-Jiménez, Víctor; Estévez-López, Fernando; Camiletti-Moirón, Daniel; Martín-Martín, Jose Jesús; Aranda, Pilar; Delgado-Fernández, Manuel; Aparicio, Virginia A

    2015-01-01

    BACKGROUND: The high prevalence of women that do not reach the recommended level of physical activity is worrisome. A sedentary lifestyle has negative consequences on health status and increases health care costs. The main objective of this project is to assess the cost-effectiveness of a primary ca

  2. Cost-effectiveness of an exercise intervention program in perimenopausal women : the Fitness League Against MENopause COst (FLAMENCO) randomized controlled trial

    NARCIS (Netherlands)

    Carbonell-Baeza, Ana; Soriano-Maldonado, Alberto; Gallo, Francisco Javier; López del Amo, María Puerto; Ruiz-Cabello, Pilar; Andrade, Ana; Borges-Cosic, Milkana; Peces-Rama, Antonio Rubén; Spacírová, Zuzana; Álvarez-Gallardo, Inmaculada C; García-Mochón, Leticia; Segura-Jiménez, Víctor; Estévez-López, Fernando|info:eu-repo/dai/nl/412501031; Camiletti-Moirón, Daniel; Martín-Martín, Jose Jesús; Aranda, Pilar; Delgado-Fernández, Manuel; Aparicio, Virginia A

    2015-01-01

    BACKGROUND: The high prevalence of women that do not reach the recommended level of physical activity is worrisome. A sedentary lifestyle has negative consequences on health status and increases health care costs. The main objective of this project is to assess the cost-effectiveness of a primary

  3. Cost-effectiveness of an exercise intervention program in perimenopausal women : the Fitness League Against MENopause COst (FLAMENCO) randomized controlled trial

    NARCIS (Netherlands)

    Carbonell-Baeza, Ana; Soriano-Maldonado, Alberto; Gallo, Francisco Javier; López del Amo, María Puerto; Ruiz-Cabello, Pilar; Andrade, Ana; Borges-Cosic, Milkana; Peces-Rama, Antonio Rubén; Spacírová, Zuzana; Álvarez-Gallardo, Inmaculada C; García-Mochón, Leticia; Segura-Jiménez, Víctor; Estévez-López, Fernando; Camiletti-Moirón, Daniel; Martín-Martín, Jose Jesús; Aranda, Pilar; Delgado-Fernández, Manuel; Aparicio, Virginia A

    2015-01-01

    BACKGROUND: The high prevalence of women that do not reach the recommended level of physical activity is worrisome. A sedentary lifestyle has negative consequences on health status and increases health care costs. The main objective of this project is to assess the cost-effectiveness of a primary ca

  4. Alendronate in early postmenopausal women

    DEFF Research Database (Denmark)

    Ravn, Pernille; Weiss, S R; Rodriguez-Portales, J A

    2000-01-01

    consented to continue and completed the extension. We are reporting data from groups using the dose of alendronate currently approved for osteoporosis prevention (5 mg) or from the group in which alendronate treatment was withdrawn: 52 women received alendronate (5 mg) for 5 yr (group I), 56 received 3 yr...

  5. Application value of quantitative tissue velocity imaging in the differential diagnosis of coronary heart disease in perimenopausal women%定量组织速度成像在围绝经期妇女冠心病鉴别诊断中的应用价值

    Institute of Scientific and Technical Information of China (English)

    杨燕

    2015-01-01

    Chest tightness,shortness of breath,palpitation and other symptoms of perimenopausal women are often diagnosed as"coronary heart disease".The application of two dimensional ultrasound beckoning diagram combined with quantitative tissue velocity imaging(QTVI) analyze the heart and the ventricular wall motion.It has a higher unity compared its results with coronary artery.This method has important application value in perimenopausal women with coronary heart disease diagnosis and differential diagnosis.%围绝经期妇女表现的胸闷、气短、心悸等症状常初诊为“冠心病”,应用二维超声心动图结合定量组织速度成像(QTVI)对患者进行心脏各室壁运动分析,将其结果与冠状动脉造影比较有较高的统一性,故此技术在围绝经期女性冠心病诊断及鉴别诊断中有着重要的应用价值。

  6. Impact of beverage consumption, age, and site dependency on dual energy X-ray absorptiometry (DEXA) measurements in perimenopausal women: a prospective study.

    Science.gov (United States)

    Lo, Huan-Chu; Kuo, Duen-Pang; Chen, Yen-Lin

    2017-08-01

    The aim of this study was to determine the best site for bone mineral density (BMD) measurements based on T-scores, age, and beverage consumption. In this prospective study, 271 women stratified by age (average age: 61.9 years) underwent dual energy X-ray absorptiometry (DEXA) scanning of their lumbar spine, hips, and forearms. Osteoporosis was defined as a BMD of 2.5 standard deviations or more below the mean peak bone mass based on a reference population of adult women (translated as a T-score ≤ -2.5), as measured by DEXA. Participants were also evaluated regarding alcohol and caffeine consumption by a semiquantitative questionnaire. A significant discrepancy was observed in the classification of osteoporosis at different locations, with hip and forearm showing the best correlation (Pearson's r = 0.627, p consumption. In the group ≤ 50 years of age, lumbar spine and forearm T-scores were only associated with alcohol consumption. In the group over 50 years of age, hip and forearm T-scores were only associated with caffeine consumption. Bone mineral density measurements at the hip and forearm correlated with caffeine consumption in elderly Taiwanese women. This is an important finding since age and caffeine consumption are known risk factors for osteoporosis.

  7. 围绝经期女性元认知相关因素的初步研究%A preliminary study on relevant factors of the metacognition of perimenopausal women

    Institute of Scientific and Technical Information of China (English)

    王相兰; 魏钦令; 李冠英; 韩自力; 张晋碚; 李凌江

    2015-01-01

    目的:初步探索围绝经期女性元认知的相关因素。方法纳入2012年10月至2013年6月广告招募的围绝经期女性志愿者66名,以元认知问卷30项版(metacognition questionnaire,MCQ-30)评估被试认知自信(F1)、积极信念(F2)、认知自我意识(F3)、失控与危险(F4)和控制思想的需要(F5)等5个维度的元认知水平,以艾森克人格问卷(Eysenck personality questionnaire,EPQ)评估被试内外倾向性(E)、神经质(N)、精神质(P)和掩饰性(L)等个性心理特征,以Zung抑郁自评量表(self-rating depression scale,SDS)评估被试核心、认知、焦虑和躯体症状等抑郁症状。分析MCQ各因子与人口学资料、EPQ和SDS间的关系。结果 F1和受教育年限(β’=-0.229,P=0.035)、N分(β’=0.255,P=0.042)及L分(β’=-0.292,P=0.021)相关联;F2与受教育年限(β’=-0.260,P=0.031)、N分(β’=0.248,P=0.039)相关联;F3与SDS核心症状(β’=-0.251,P=0.037)及焦虑症状(β’=-0.248,P=0.039)相关联;F4与体质量指数(β’=0.211,P=0.048)、L分(β=0.511,P<0.001)相关联;F5与P分(β’=0.299,P=0.015)相关联。结论围绝经期女性元认知水平受其个性特征、受教育年限等多种因素影响,对认知过程的自我意识水平较低、自信心较差可能与其抑郁易感性有关。%Objective This preliminary study aimed to investigate relevant factors of the metacognition of peri⁃menopausal women. Methods Total 66 perimenopausal women voluntarily participated in this study from October 2012 to July 2013. The Metacognitions Questionnaire 30-item version (MCQ-30) was used to assess metacognition from 5 di⁃mensions including cognitive confidence (F1), positive beliefs (F2), cognitive self-consciousness (F3), uncontrollability and danger (F4), and need to control thoughts (F5). Eysenck Personality Questionnaire was utilized

  8. Cardiovascular Fat, Menopause, and Sex Hormones in Women: The SWAN Cardiovascular Fat Ancillary Study.

    Science.gov (United States)

    El Khoudary, Samar R; Shields, Kelly J; Janssen, Imke; Hanley, Carrie; Budoff, Matthew J; Barinas-Mitchell, Emma; Everson-Rose, Susan A; Powell, Lynda H; Matthews, Karen A

    2015-09-01

    Cardiovascular risk increases in women after menopause. Mounting evidence demonstrates a role of cardiovascular fat (CF) in the pathogenesis of coronary heart disease, but no research has examined CF in relation to sex hormones or menopausal status in women. The objective was to determine the relationship between CF depots, menopausal status, and endogenous sex hormones. Cross-sectional and longitudinal study designs were used. The setting included the Study of Women's Health Across the Nation (SWAN) Heart and Cardiovascular Fat Ancillary Study. A total of 456 women (mean age, 50.75 y); 62% premenopausal/early perimenopausal, and 38% late peri-/postmenopausal. Menopausal status, endogenous sex hormones measured simultaneously with CF volumes, and circulating estradiol available 4.80 years (median) before CF measures. Volumes of CF (epicardial adipose tissue [EAT], paracardial adipose tissue [PAT], total heart adipose tissue [TAT = EAT + PAT], and aortic perivascular adipose tissue [PVAT]). In final models, late peri-/postmenopausal women had 9.88% more EAT, 20.72% more PAT, and 11.69% more TAT volumes than pre-/early perimenopausal women (P fat compared with pre-/early perimenopausal women independent of age, obesity, and other covariates. Endogenous sex hormones are associated with CF. Perhaps CF plays a role in the higher risk of coronary heart disease reported in women after menopause.

  9. Endometriosis presenting as carcinoma colon in a perimenopausal woman

    Directory of Open Access Journals (Sweden)

    Tanuja Muthyala

    2015-01-01

    Full Text Available Endometriosis is a common benign disease of reproductive age women, and can involve the intestinal tract. Inconsistent clinical presentation, similar features on radiological imaging and colonoscopy with other inflammatory and malignant lesions of the bowel makes the preoperative diagnosis of bowel endometriosis difficult. We present a case of a 42-year-old perimenopausal female clinically presented, investigated and managed in the lines of carcinoma of sigmoid colon. She underwent terminal ileac resection with end to end anastomoses, Hartmann′s procedure and total hysterectomy with bilateral salpingoophorectomy. The histopathological report revealed endometriosis of small intestine, large intestine, mesentery, right ovary and adenomyoma of uterus. Thus, bowel endometriosis should also be considered as differential diagnosis in reproductive age women with gastrointestinal symptoms or intestinal mass of uncertain diagnosis.

  10. The effective evaluation of holistic nursing intervention to improve the physical and mental health of perimenopause women in community%整体护理程序对改善社区围绝经期妇女身心健康效果的调查研究

    Institute of Scientific and Technical Information of China (English)

    钟士銮

    2010-01-01

    目的 探讨整体护理程序对改善社区围绝经期妇女身心健康的效果.方法 将入选者随机分为干预组与对照组各108例.采用SCL-90症状自评量表评定病人的心理状态;采用自行设计的"社区围绝经期妇女健康知识调查"了解患者对围绝经期相关知识的认知及自我保健的掌握情况;采用SF-36健康调查量表评定生存质量.结果 干预组实施整体护理干预后SCL-90各因子均较干预前显著降低(P<0.01);对照组除强迫因子外,其他各因子变化不明显,差异无统计学意义(P>0.05).干预后12个月2组生存质量比较,干预组生活质量8个维度显著高于对照组,2组比较有显著性差异(P<0.01).干预后2组围绝经期相关知识、自我保健掌握情况比较,入组时2组妇女健康知识掌握情况无显著性差异(P>0.05).结论 整体护理干预能改善社区围绝经期妇女的身心健康,是提高社区妇女生存质量的重要措施.%Objective To explore the effect of holistic nursing intervention to improve the physical and mental health of perimennpause women in community. Methods Two hundred and sixteen perimenopause women were randomly divided into intervention and control groups, 108 cases in each group. At the begin and the end of inquiry, the symptom checklist 90 (SCL-90) and the MOS item short from health survey (SF-36) were used to evaluate respectively the psychological state and life quality, meanwhile the situation, knowledge on perimenopause and self-care were measured by self - designed health knowledge questionnaire. Results All factors in SCL - 90 were lower significantly after implementing holistic nursing ( P< 0. 001 ), eight queries of life quality in SF - 36 in intervention group were higher significantly than those in control group after 12 months of intervention ( P < 0.01 ) . The difference between perimenopause and self - care knowledge at the begin and the end of inquiry in two groups was not

  11. Clinicopathological Spectrum of Endometrial Changes in Peri-menopausal and Post-menopausal Abnormal Uterine Bleeding: A 2 Years Study

    OpenAIRE

    2013-01-01

    Background: Abnormal uterine bleeding is the Common presenting complaint in Gynaecology Outpatient Department in all age groups. It is due to the anovulatory cycles which are commonly seen in adolescent and peri-menopausal women. Abnormal uterine bleeding is caused by wide variety of organic or non-organic causes. Histopathological examination of endometrial sample remains the gold standard for diagnosis of endometrial pathology.

  12. Endokrinologie in der Lebensmitte: Die Perimenopause.

    Directory of Open Access Journals (Sweden)

    Seifert-Klauss V

    2012-01-01

    Full Text Available Anhand dreier Kasuistiken aus der gynäkologischen Hormonsprechstunde werden beispielhaft besondere Situationen und eine darauf individuell abgestimmte Hormontherapie während der Perimenopause vorgestellt. Der erste Fall beschreibt eine 47-jährige Patientin mit ausgeprägter perimenopausaler Symptomatik und Östrogen-Dominanz. Die Dokumentation über 5 Jahre illustriert die Probleme, die perimenopausal durch die endogene Überstimulation der Ovarien entstehen können. Über die Unvorhersehbarkeit der perimenopausalen Hormonschwankungen, die sich in Brustspannen und Wassereinlagerungen bei hohen Östrogenspiegeln sowie Hitzewallungen und Schweißausbrüchen bei Abfall der endogenen Östrogenspiegel äußern, sollten Patientinnen aufgeklärt werden. Durch eine zyklische Gestagensubstitution kann bei Östrogendominanz unter Umständen mehr Beschwerdeerleichterung erreicht werden als durch eine hochdosierte Östrogentherapie. Fall 2 stellt eine 47-jährige Patientin mit Epilepsie vor, deren perimenopausal bedingte Hormonschwankungen zu vermehrten Anfällen führen. Hier gilt es abzuklären, ob die Anfälle durch stark erhöhte Estradiolspiegel, die zum Ende des Zyklus hin abfallen, begünstigt werden oder aber die Art und Entstehungsgeschichte der Epilepsie nicht auf eine andere Interaktion zwischen Perimenopause und Anfällen hindeuten. In der dritten Kasuistik geht es um eine 54- jährige Patientin mit Morbus Basedow, bei der die ausgeprägte Interaktion zwischen der Schilddrüseneinstellung und den steigenden FSH-, LHsowie unvorhersehbar wechselnden Östrogenspiegeln aufgezeigt und eine individuelle symptombezogene Hormontherapie erforderlich ist.

  13. Genotypes of vitamin D and estrogen receptors in pre and perimenopausal women from Córdoba, Argentina Genotipos de los receptores de vitamina D y de estrógeno en mujeres pre y perimenopáusicas de Córdoba, Argentina

    Directory of Open Access Journals (Sweden)

    María Ulla

    2007-02-01

    Full Text Available The aim of this study was to determine the frequency of vitamin D receptor and estrogen receptor genotypes and their relationship with the lumbar spine or femoral neck bone mineral density in healthy pre and perimenopausal women from Córdoba (Argentina and adjacent areas. Genotypes were assessed by restriction fragment length polymorphism-polymerase chain reaction technique. Bsm I and Fok I for vitamin D receptor gene and XbaI and PvuII for estrogen receptor gene were used as restrictases. Two hundred and ten healthy pre and perimenopausal women were recruited and analyzed by age. Calcemia and serum parathyroid hormone did not change, but serum P and b-CrossLaps decreased with age. Femoral neck bone mineral density decreased significantly after 30 years old. Vitamin D receptor and estrogen receptor genotype frequencies were similar to those from other Caucasian women. No association between vitamin D receptor and estrogen receptor genotypes with the lumbar spine or femoral neck bone mineral density has been detected. Analysis of interaction between vitamin D receptor and estrogen receptor genes using covariates such as age, height and body mass index did not show any influence of the combination of those genotypes on bone mineral density. Lifestyle, smoking and alcohol intake had no effect on lumbar spine and femoral neck bone mineral density. To conclude, these data do not support the hypothesis that vitamin D receptor and estrogen receptor genotypes influence on lumbar spine and femoral neck bone mineral density in healthy pre and perimenopausal women from this area of Argentina.El propósito del estudio fue determinar la frecuencia de los genotipos de los receptores de vitamina D y de estrógeno y su relación con la densidad mineral ósea en mujeres sanas pre y perimenopáusicas de la ciudad de Córdoba y alrededores. Los genotipos se determinaron con la técnica de reacción en cadena de la polimerasa y análisis de los polimorfismos de

  14. Overweight, obesity and female sexuality in perimenopause: a preliminary report

    Directory of Open Access Journals (Sweden)

    Grażyna Jarząbek-Bielecka

    2015-06-01

    Full Text Available Introduction: The research was conducted among patients of the Department of Perinatology and Gynaecology of the Poznań University of Medical Sciences. Its aim was to investigate the influence of overweight and obesity on female sexuality during the perimenopausal period. Preliminary results of the research are presented in the thesis, which was as a matter of fact intended as a preliminary report. The examination of sexual functions of the patients was performed with the use of the Female Sexual Function Index (FSFI form. Material and methods: Sixty-one women during the perimenopausal period filled out the survey, with the average age of these women being 51 years. Forty-two of the examined women had an appropriate body mass index (BMI, i.e. between 18.5 and 25, while for 19 of the women, the BMI was above normal. For statistical analysis and in order to assess the differences between the two above-mentioned groups of patients, the nonparametric Mann-Whitney test was applied. A statistically significant value was assumed at p < 0.05. The results of the conducted research indicated no such difference between the women with differing BMI for the specific domains of the FSFI test. Results: The results obtained show that research in the area needs to be continued. Conclusions: All the hitherto existing scientific studies also seem to indicate that the influence of overweight and obesity on female sexuality during the perimenopause has not yet been unambiguously proven. Beyond any doubt, however, sexual disorders appear in women at this time of life and the factors which determine them can vary greatly. Given the character of the situation, women ought to be supported both by a team of specialists representing different branches of medicine as well as by their relatives. The whole situation also calls for more research of the important subject matter.

  15. Effect of nursing intervention on quality of sleep and quality of life in perimenopausal women with insomnia%护理干预对围绝经期妇女失眠症患者睡眠及生活质量的影响

    Institute of Scientific and Technical Information of China (English)

    高黎妮

    2015-01-01

    Objective To observe the effect of nursing intervention on quality of sleep and life of perimenopausal women with insomnia.Methods A total of 78 perimenopausal women with insomnia were enrolled and divided into intervention group and control group.The control group was treated with conventional medication,while the intervention group received nursing interven-tion additionally.The Pittsburgh Sleep Quality Index(PSQI)was used to assessed the quality of sleep and the WHO Quality of Life-BREF (WHOQOL-BREF)was used to assessed the quality of life after 12 weeks of treatment.Results After 12 weeks treatment,the score of two groups significantly better in all domains of PSQI and WHOQOL-BREF than before the treatment(P <0.05).There were significant difference in all domains score of PSQI and WHOQOL-BREF of the two groups after 12 weeks treatment.Conclusions The nursing intervention can obviously improve the quality of sleep and life of perimenopausal women with insomnia.%目的:探讨护理干预对围绝经期妇女失眠症患者睡眠质量及生活质量的影响。方法选择在本院门诊就诊的围绝经期妇女失眠症患者78例,随机分为干预组和对照组。对照组给予常规药物治疗,干预组在药物治疗的基础上进行护理干预,治疗12周后采用匹茨堡睡眠质量指数(PSQI)评定患者的睡眠质量,采用世界卫生组织生活质量评定量表简表(WHOQOL-BREF)评定患者的生活质量。结果治疗12周后2组患者 PSQI 总分及各因子分均较治疗前降低,WHOQOL-BREF 量表的各领域得分均较治疗前增加,差异有统计学意义(P <0.05);通过组间比较发现,治疗12周后2组患者 PSQI总分及各因子分及 WHOQOL-BREF 量表的各领域得分组间差异均具有统计学意义(P <0.05)。结论在采用药物治疗的基础上,对围绝经期妇女失眠症患者进行护理干预,能进一步改善患者的睡眠质量,提高患者的疗效和生活质量。

  16. 两种宫颈锥切术在围绝经期女性宫颈上皮内瘤变Ⅲ中的效果分析%The Effect Analysis of Two Kinds of Cervical Cone Cutting Technique in Perimenopausal Women Cervical Intraepithelial Neoplasia Ⅲ Change

    Institute of Scientific and Technical Information of China (English)

    刘鹰; 姚旭阳; 陈敬

    2013-01-01

    Objective:To observe the clinical effect of cervical cold knife cone cutting technique and cervical circular electric cutting in the treatment of perimenopausal women cervical intraepithelial neoplasia become Ⅲ level.Methods:200 cases of perimenopausal women cervical intraepithelial neoplasia becomeⅢ stage patients were selected and randomly divided into treatment group and control group,who were given cervical circular electrotomy and cervical cold knife cone cutting operation treatment,observation two sets of patients during operation time,amount of bleeding,postoperative infection and treatment success rate for the first time.Results:The treatment group patients surgical treatment time,intraoperative amount of bleeding were less than control group patients,with significant difference(P0.05).Conclusion:Cold knife cone cutting surgical in treatment of cervical intraepithelial neoplasia become Ⅲ stage postoperative infection probability is small,while round electrotomy is shorter operation time,less intraoperative amount of bleeding,curative effect is similar for two kinds of methodall for the treatment of cervical intraepithelial neoplasia of grade change Ⅲ .%  目的:观察宫颈冷刀锥切术和宫颈环行电切对治疗围绝经期女性宫颈上皮内瘤变Ⅲ级的临床效果.方法:选择笔者所在医院进行治疗的围绝经期女性宫颈上皮内瘤变Ⅲ级患者200例,随机分成治疗组和对照组,分别给予宫颈环行电切术和宫颈冷刀锥切术治疗,观察两组患者的手术时间、术中出血量、术后感染率及首次治疗成功率.结果:治疗组患者手术治疗时间、术中出血量均少于对照组患者,差异有统计学意义(P0.05).结论:冷刀锥切术治疗宫颈上皮内瘤变Ⅲ级术后感染几率较小,环行电切术则手术时间短、术中出血量少,两类方法疗效相似,均为治疗宫颈上皮内瘤变Ⅲ级的有效方法.

  17. A pilot study of the feasibility of long-term human bone balance during perimenopause using a {sup 41}Ca tracer

    Energy Technology Data Exchange (ETDEWEB)

    Hui, S.K. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel) and Department of Therapeutic Radiology-Radiation Oncology, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 494, Minneapolis, MN 55455 (United States)]. E-mail: huixx019@umn.edu; Prior, J. [Deparment of Medicine/Endocrinology, University of British Columbia, Vancouver, B.C., V5Z 1C6 (Canada); Gelbart, Z. [TRIUMF, Vancouver, B.C., V6T2A3 (Canada); Johnson, R.R. [TRIUMF, Vancouver, B.C., V6T2A3 (Canada); Lentle, B.C. [Department of Radiology, University of British Columbia, British Columbia, V8M 1V4 (Canada); Paul, M. [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel)

    2007-06-15

    The mechanisms governing calcium fluxes during bone remodeling processes in perimenopausal women are poorly known. Despite higher, albeit erratic, estradiol levels in perimenopause, spine bone loss is greater than during the first five years past the final menstrual flow when estradiol becomes low. Understanding changes during this dynamic transition are important to prevent fragility fractures in midlife and older women. The exploration of long-lived {sup 41}Ca (T {sub 1/2} = 1.04 x 10{sup 5} yrs) tracer measurements using accelerator mass spectrometry (AMS) leads to the possibility of monitoring bone remodeling balance. With this new technology, we explored a pilot long-term feasibility study of bone health by measuring the {sup 41}Ca trace element in urine for six years from premenopausal to later perimenopausal phases in one midlife woman. We measured bone mineral density in parallel.

  18. Effect of paroxetine combined with climen on hormone levels and neurotransmitters in patients with perimenopausal depression

    Institute of Scientific and Technical Information of China (English)

    Wei-Ling Huang

    2016-01-01

    Objective:To analyze the effect of paroxetine combined with climen on hormone levels and neurotransmitters in patients with perimenopausal depression. Methods:A total of 96 cases of perimenopausal women who met the diagnosis of depression and were treated in our hospital from July 2012 to March 2015 were selected as research subjects and randomly divided into observation group and control group, each group with 48 cases. Control group received paroxetine therapy alone, observation group received paroxetine combined with climen therapy, serum hormone and neurotransmitter levels of two groups were compared, and severity of menopause and depression was detected after treatment. Results:E2 level of observation group after treatment was higher than that of control group, and levels of FSH and LH were lower than those of control group;serum NE, 5-HT, DA, Glu and Asp values of observation group after treatment were higher than those of control group, and values of GABA and Gly were lower than those of control group;KI, MRS and HAMD scores of observation group after treatment were lower than those of control group. Conclusion:Paroxetine combined with climen therapy for patients with perimenopausal depression can effectively optimize the levels of hormones and neurotransmitters in patients and reduce the symptom severity of menopause and depression.

  19. The relationship of Serum sex hormone, 5-HT levels of anxiety and depression in perimenopausal women%血清性激素、5-HT水平与围绝经期妇女抑郁焦虑的关系

    Institute of Scientific and Technical Information of China (English)

    买热木古·阿布都热依木; 范桂君; 阿怕尔·卡哈尔; 热依拉·哈利别克; 李瑞晟

    2016-01-01

    目的 探讨血清性激素、5-羟色胺(5-HT)水平与围绝经期妇女抑郁焦虑的关系.方法 2015年4月至2016年4月选取180例无躯体器质性病变及其它精神障碍疾病的围绝经期妇女为调查研究对象,根据焦虑自评量表(SAS)及抑郁自评量表(SDS)将调查对象分为对照组(n=54),抑郁组(n=38),焦虑组(n=42)及抑郁焦虑共病组(n=46),测定各组血清中雌二醇(E2)、孕酮(P)、垂体催乳素(PRL)、卵泡生成素(FSH)、睾酮(T)及黄体生成素(LH)、5-羟色胺(5-HT)水平.结果 四组血清FSH、LH、PRL水平比较无统计学差异(P>0.05),四组血清E2、P、T、5-HT水平比较有统计学差异(P<0.05).经Pearson相关系数分析,围绝经期妇女血清P与SDS评分、SAS评分呈负相关(P<0.05),血清T与SDS评分、SAS评分呈正相关(P<0.05),血清5-HT与SDS呈正相关(P<0.05).结论 性激素与围绝经期抑郁焦虑的发生有密切的关系,5-HT可与性激素共同影响抑郁症的发生.%Objective To investigate the relationship of Serum sex hormone,5-HT levels of anxiety and depression in perimenopausal women.Methods 180 cases of non-organic disease and other physical disorders in perimenopausal women were divided into control group (n =54),depression group (n =38),anxiety group (n =42) and comorbid depression and anxiety group (n =46) based on self-rating anxiety scale (SAS) and Self-Rating Depression Scale (SDS) from April 2015 to April 2016. The levels of estradiol (E2),progesterone (P),prolactin (PRL),follicle stimulating hormone (FSH),testosterone (T),luteinizing hormone (LH) and 5-HT were determed.Results The levels of FSH,LH,PRL of four groups were had no significant difference (P> 0.05) The levels of E2、P、T、5-HTof four groups had significant difference (P < 0.05).Pearson correlation coefficient,serum P had negatively correlation with SDS,SAS (P < 0.05),serum T had positively correlation with SDS,SAS (P < 0.05),serum 5-HT and SDS was positively

  20. 'ah famous citie' : women, writing, and early modern London

    NARCIS (Netherlands)

    Wilcox, Helen

    2010-01-01

    This article explores aspects of the textual relationship between women and early modern London by examining three verbal 'snapshots' of the city in works either written by women or focusing on women in their urban environment. The first text, Isabella Whitney's 'Wyll and Testament' (1573), addresse

  1. 'ah famous citie' : women, writing, and early modern London

    NARCIS (Netherlands)

    Wilcox - Boulton, Helen

    2010-01-01

    This article explores aspects of the textual relationship between women and early modern London by examining three verbal 'snapshots' of the city in works either written by women or focusing on women in their urban environment. The first text, Isabella Whitney's 'Wyll and Testament' (1573), addresse

  2. 围绝经期女性静息状态下丘脑功能连接与性激素和抑郁症状的相关性%The resting-state functional connectivity of the hypothalamus and its relationships with gonadal steroid hormones and depression symptoms in perimenopausal women

    Institute of Scientific and Technical Information of China (English)

    王相兰; 陶炯; 钟智勇; 刘莎; 韩自力; 张晋碚; 李凌江

    2015-01-01

    目的 探索静息状态围绝经期女性下丘脑的功能连接及其与性激素和抑郁症状的相关性.方法 本研究纳入2012年10月至2013年6月在广州中山大学附属第三医院精神科广告招募的围绝经期女性志愿者66名,以Zung抑郁自评量表(ZSDS)评估其抑郁症状,以化学发光免疫法检测其雌二醇、睾酮、孕酮水平;采集3.0T静息状态功能磁共振成像数据,以下丘脑为种子区,计算基于体素的下丘脑功能连接z值图;经统计参数图(SPM)单样本t检验生成下丘脑功能连接图;用SPM多重回归分析性激素相关的下丘脑功能连接脑区,然后用Pearson相关分析性激素相关脑区平均z值与ZSDS评分的相关性.结果 围绝经期女性下丘脑功能连接脑区主要为外侧额叶下回,内侧前额叶,背外侧前额叶,眶额叶皮质,膝下皮质,前扣带回,后扣带回,楔形回和楔前叶,海马区,角回(FDR校正q<0.05).其中,睾酮与右侧角回-下丘脑连接强度正相关,与右侧膝下皮质-下丘脑和双侧内侧额上回-下丘脑连接强度负相关(PAlphasim<0.05),同时右侧膝下皮质平均z值与ZSDS总分(r=0.279,P=0.023)、核心症状分(r=0.278,P=0.024)及躯体症状分(r=0.357,P=0.003)正相关.结论 围绝经期女性静息状态下丘脑和抑郁相关网络及默认网络存在广泛功能连接,而血浆雄激素水平对部分脑区与下丘脑的功能连接强度具有调整作用,并可能降低围绝经期女性对抑郁的易感性.%Objective This study aimed to investigate the resting-state functional connectivity of the hypothalamus and its relationships with gonadal steroid hormones and depression symptoms in perimenopausal women.Methods Total 66 perimenopausal women voluntarily participated in this study from October 2012 to June 2013.Zung Self-rating Depression Scale (ZSDS) was used to assess depression symptoms.Plasma gonadal steroid hormones including estradiol, testosterone, and progesterone were

  3. 新疆墨玉县农村维吾尔族围绝经期妇女超重和肥胖状况流行病学调查%Epidemiology of overweight and obesity among rural Uyghur perimenopausal women in Moyu county of Xinjiang

    Institute of Scientific and Technical Information of China (English)

    张丽; 王顺; 桑晓红; 李素华; 刘健

    2016-01-01

    目的:探讨新疆墨玉县农村维吾尔族围绝经期妇女超重和肥胖患病率的变化和流行特点,为肥胖症的预防和控制提供科学依据。方法2007年采用多阶段分层抽样的方法从墨玉县364个自然村中抽取15个村中的1650名维吾尔族成人,完成慢性肾脏病等慢性疾病患病率的横断面调查,资料完整的40~65岁的围绝经期女性为274人;2013年再次对该人群进行跟踪调查,资料完整的围绝经期女性为361人,2次调查均进行问卷调查、体格检查。比较维吾尔族围绝经期妇女的超重率和肥胖率。结果2007-2013年墨玉县农村维吾尔族围绝经期妇女超重、肥胖患病率增加明显,依照中国肥胖问题工作组(WGOC)的标准,调查人群2007年和2013年超重患病率分别为27.7%和31.6%,肥胖患病率分别为18.6%和29.9%(χ2=11.803,P =0.003)。中心性肥胖患病率分别为73.7%和84.2%(χ2=10.584,P >0.05)。超重和肥胖高发年龄为40~59岁,尤其以40~49岁显著,2007-2013年40~49岁肥胖比例增加达2倍(χ2=30.17,P <0.05)。结论农村维吾尔族围绝经期妇女超重和肥胖问题严重,应积极开展适合于地方特点的防治工作。%Objective To investigate the prevalence and epidemic characteristics of overweight and obesity changes among rural Uyghur perimenopausal women in Moyu county.Methods We had conducted an epi-demiological survey of CKD in Uyghur adults from 15 out of 364 villages of Moyu county in 2007.The population were randomly selected by using a stratified,multistage sampling and were investigated again in 2013, and all subjects received the questionnaire, physical examination and biochemical analysis. Uyghur perimenopausal women aged 40-65 years with complete data collection were 274 in 2007 and 361 in 2013,respectively.To compare the prevalence rate of overweight,general and central

  4. Cardiovascular Fat, Menopause, and Sex Hormones in Women: The SWAN Cardiovascular Fat Ancillary Study

    Science.gov (United States)

    Shields, Kelly J.; Janssen, Imke; Hanley, Carrie; Budoff, Matthew J.; Barinas-Mitchell, Emma; Everson-Rose, Susan A.; Powell, Lynda H.; Matthews, Karen A.

    2015-01-01

    Context: Cardiovascular risk increases in women after menopause. Mounting evidence demonstrates a role of cardiovascular fat (CF) in the pathogenesis of coronary heart disease, but no research has examined CF in relation to sex hormones or menopausal status in women. Objective: The objective was to determine the relationship between CF depots, menopausal status, and endogenous sex hormones. Design: Cross-sectional and longitudinal study designs were used. Setting: The setting included the Study of Women's Health Across the Nation (SWAN) Heart and Cardiovascular Fat Ancillary Study. Participants: A total of 456 women (mean age, 50.75 y); 62% premenopausal/early perimenopausal, and 38% late peri-/postmenopausal. Intervention: Menopausal status, endogenous sex hormones measured simultaneously with CF volumes, and circulating estradiol available 4.80 years (median) before CF measures. Main Outcome Measures: Volumes of CF (epicardial adipose tissue [EAT], paracardial adipose tissue [PAT], total heart adipose tissue [TAT = EAT + PAT], and aortic perivascular adipose tissue [PVAT]). Results: In final models, late peri-/postmenopausal women had 9.88% more EAT, 20.72% more PAT, and 11.69% more TAT volumes than pre-/early perimenopausal women (P < .05). PVAT was not associated with menopausal status. In final models, lower estradiol concentrations were associated with greater volumes of PAT and TAT (P < .05). Women with the greatest reduction in estradiol since baseline had greater volumes of PAT compared to women with the least reduction (P = .02). Conclusions: Late peri-/postmenopausal women have greater volumes of heart fat compared with pre-/early perimenopausal women independent of age, obesity, and other covariates. Endogenous sex hormones are associated with CF. Perhaps CF plays a role in the higher risk of coronary heart disease reported in women after menopause. PMID:26176800

  5. Gender and Early Learning Environments. Research on Women and Education

    Science.gov (United States)

    Irby, Beverly, Ed.; Brown, Genevieve H., Ed.

    2011-01-01

    The Research on Women and Education SIG of the American Educational Research Association presents the third book in its series, Gender and Early Learning Environments. Finding after the publication of Gender and Schooling in the Early Years, the second book in the series, that there was and is a paucity of published literature on early childhood…

  6. Polycystic ovary syndrome: clinical implication in perimenopause

    OpenAIRE

    Monika Lenart-Lipińska; Beata Matyjaszek-Matuszek; Ewa Woźniakowska; Janusz Solski; Tarach, Jerzy S.; Tomasz Paszkowski

    2014-01-01

    Polycystic ovary syndrome (PCOS), a hyperandrogenic disorder, is the commonest endocrinopathy in premenopausal women. This syndrome is associated with fertility problems, clinical manifestations of hyperandrogenism and metabolic disturbances, particularly insulin resistance and obesity. There is a great body of evidence that patients with PCOS present multiple cardiovascular risk factors and cluster components of metabolic syndrome from early ages. The presence of comorbidities such as abdomi...

  7. The perimenopause: definitions, demography, and physiology.

    Science.gov (United States)

    Speroff, Leon

    2002-09-01

    The perimenopausal years should serve to remind patients and clinicians that this is a time for education. Certainly preventive health care education is important throughout life, but at the time of midlife, a review of the major health issues can be especially rewarding. The failure to respond appropriately (by either clinician or patient) easily leads to a loss of the patient from a practice, but equally, if not more importantly, is the probability that the loss of a patient from a practice means that another woman has lost her involvement in a preventive health care program. Contrary to popular opinion, the menopause is not a signal of impending decline, but rather a wonderful phenomenon that can signal the start of something positive, a good health program.

  8. 血清性激素、血脂水平与围绝经期症状的相关性%Correlation between serum sex hormones levels, blood lipids levels and perimenopausal symptoms

    Institute of Scientific and Technical Information of China (English)

    秦家云; 刘晓燕; 王丽平; 王艳; 彭丹红

    2013-01-01

    Objective: To research the correlation between serum sex hormones levels, blood lipids levels and perimenopausal symptoms. Methods: The general condition, perimenopausal quality of life, and Kupperman index ( KMI) of 215 women were investigated, then 90 study objects were selected and divided into five groups: control group (20 women) , perimenopausal group (17 women) , early postmenopausal group (21 women) , late postmenopausal group (22 women), and hormone replacement therapy (HRT) group (10 women); the serum levels of estradiol, follicle - stimulating hormone (FSH) , testosterone (T) , total cholesterol (TC) , and triglyceride (TG) were detected and compared, respectively; the perimenopausal symptoms and KMI were compared, and the correlation was analyzed. Results: Compared with control group, the serum levels of estradiol and T in perimenopausal group, early postmenopausal group, and late postmenopausal group decreased significantly (P < 0. 05) . KMIs in perimenopausal group, early postmenopausal group, and late postmenopausal group increased gradually, which were statistically significantly higher than that in control group (P < 0. 05) . There was a negative correlation between estradiol level and KMI (γ = - 0. 334, P = 0. 001) , there was a negative correlation between T level and KMI (γ = -0. 270, P =0. 010) , there was a positive correlation between FSH level and KMI (γ = 0. 504, P = 0. 000 ) ; compared with control group, serum TC and TG levels in perimenopausal group, early postmenopausal group, and late postmenopausal group increased significantly (P < 0. 05 ) , there was a positive correlation between serum TG and KM (γ=0. 294, P = 0. 005) , there was a positive correlation between TC and KMI (γ = 0. 244, P=0. 021) . Conclusion: Serum estradiol and T levels decrease obviously in postmenopausal women, but serum FSH level increases. There is a negative correlation between KMI and serum estradiol, but KMI is positively correlated with serum FSH. Serum

  9. Middle-Ageo Women Face Early Retirement

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    A woman worker in Shanghai recently wrote to the Shanghai Municipal Women’s Federation: "With the deepening of the economic reform, our factory has started to make huge reductions in the staff and has made it a rule that all women workers aged 45 or older must leave their posts and wait for retirement. I am one of them. Of course, society won’t progress if we don’t carry out the reform. But don’t the interests of society and the interests of women coincide? Where is the answer out for China’s women workers?" At the end of 1992 an investigation by the Women Workers Department under

  10. The Effect of Early Marriages and Early Childbearing on Women's Nutritional Status in India.

    Science.gov (United States)

    Goli, Srinivas; Rammohan, Anu; Singh, Deepti

    2015-08-01

    The consequences of early childbearing on the growth and nutritional status of women in India has not been quantified in previous studies. Our study aimed to fill this gap by analysing the association between early marriage and early childbearing on nutritional status of Indian women, with a focus on Bihar and Andhra Pradesh, the two states accounting for the highest proportion of women marrying and giving first birth before 18 years of age. Our findings revealed that a substantial number of women were married before 18 years and thereby exposed to early pregnancy. Furthermore, a significantly higher proportion of women in the 'thin' category were married before 18 years, both in the Indian sample (33 %, p women married at higher ages. Similarly, across all our samples women whose first birth was before age 18 years also had a significantly higher probability of being in the 'thin' category across all our samples. This pattern was also observed for associations between early childbirth and anemia levels. We conclude that the net effect of the early age at marriage and age at first birth on nutritional status is significant. Our results underline the need for preventing early marriages and the consequent high adolescent pregnancies in India, particularly in high prevalence states. This will help to improve nutritional status and health care utilisation among women, thereby, prevent maternal and child mortality and thus, achieve the MDGs 4-5.

  11. Investigation on the prevalence and the types of female sexual dysfunction(FSD) of 298 cases perimenopause women%298例围绝经期女性性功能障碍患病率及患病类型调查

    Institute of Scientific and Technical Information of China (English)

    王浅浅; 阮祥燕; 田玄玄; 崔亚美; 杜鹃; Diethelm Wallwiener; Alfred O.Mueck; 代荫梅

    2014-01-01

    Objective To investigate the prevalence and the types of female sexual dysfunction ( FSD) of perimenopause women in our clinic, and the influence of menopause , age, smoking, cohabitation time, the number of pregnancy and depression on female sexual function.Methods This was a cross-sectional study .The patients from Dept .of Gynecological Endocrinology in Beijing Obstetrics and Gynecology Hospital affiliated to Capital Medical University and menopausal women from different communities of Heilongjiang and Shandong Province were investigated with questionnaires of FSFI and self rating Depression Scale ( SDS) .All data were analyzed by SPSS 13.0.Results A total of 500 questionnaires were granted and 92.2% of those were recovered .298 questionnaires were included for analysis after screening in the end .The average total score of FSFI was 23.69 and the prevalence of FSD is 58.1% in perimenopause women according to the definition of FSD , the total score of FSFI below of 26.55, in our study.According to the 6 dimensions of FSFI , the prevalence of sexual desire disorder , sexual arousal disorder , orgasm disorder , sexual satisfaction disorder , sexual pain and vaginal lubrication disorders were 50.7%, 43.3%, 35.6%, 33.6%, 29.5%and 28.5%orderly.Higher age and depression are risks for FSD (P0.05).Conclusion The prevalence of FSD of perimenopause women in our clinic is 58.1%, and the prevalence of sexual desire disorder , sexual arousal disorder , orgasm disorder , sexual satisfaction disorder , sexual pain and vaginal lubrication disorders were 50.7%, 43.3%, 35.6%, 33.6%, 29.5%and 28.5%in turn.%目的:调查中国围绝经期女性性功能障碍的患病率和患病类型,以及绝经、年龄、抑郁心理、与性伴侣同居时间、吸烟、妊娠次数等因素对女性性功能的影响。方法采用横断面研究方法,应用女性性功能量表( Female Sexual Function Index ,FSFI)、抑郁自评量表( Self Rating Depression Scale ,SDS)

  12. Effect of symptom screening combined with health education on osteoporosis prevention among peri-menopausal women%症状筛查联合健康教育预防围绝经期妇女骨质疏松的效果分析

    Institute of Scientific and Technical Information of China (English)

    陆丽娟

    2015-01-01

    目的:探讨联合症状筛查的健康教育项目预防围绝经期妇女骨质疏松的效果,为护士及其他健康工作者在促进围绝经期妇女的骨健康工作提供参考。方法对2013年3—4月社区招募的100名围绝经期妇女进行为期4周、每周1次的课堂教育,在教育前1周、教育的第2周及教育后1周对研究对象进行骨质疏松症状筛查。对症状阳性者进行为期1个月的随访。结果干预后围绝经妇女营养知识、锻炼知识、总知识、营养自我效能、锻炼自我效能、总自我效能、预防行为倾向评分分别为(18.93±3.95),(15.48±3.28),(22.52±4.50),(39.05±19.35),(47.09±24.88),(43.12±20.21),(4.10±0.70)分,分别优于干预前,差异有统计学意义( t 值分别为15.70,14.05,15.66,3.58,4.91,4.83,12.85;P<0.01)。围绝经期妇女的疼痛平均得分为(7.28±12.38)分,活动能力测试需要时间平均(10.48±1.89)s。13例患者症状阳性,经过1个月的随访,其中10例(76.92%)患者被确诊为骨质疏松。预防骨质疏松知识与健康行为倾向呈弱相关(r=0.509,P<0.01),而预防骨质疏松自我效能与健康行为倾向呈强相关(r=0.728,P<0.01)。结论联合症状筛查的健康教育项目能提高围绝经期妇女预防骨质疏松的效果,有利于围绝经期妇女进行自我筛查。%Objective To evaluate the effect of symptom screening combined with health education on osteoporosis prevention among peri-menopausal women. Methods A total of 100 peri-menopausal women were recruited in the community, who were given classroom education four weeks and once a week, symptoms screening was taken one week before the session, the second session and one week after the session, and one month follow-up was given who had positive screenings. Results After the intervention, scores of nutrition, exercise, total knowledge, self-efficacy on nutrition, self-efficacy on exercise, total self-efficacy and prevention behavior were (18. 93 ± 3

  13. Effect of estrogen metabolic enzyme cytochrome P450 gene polymorphism on susceptibility of hot flashes in perimenopause women%细胞色素P450基因多态性对围绝经期妇女潮热易感性的影响

    Institute of Scientific and Technical Information of China (English)

    张巧利; 张丽娟; 李芬

    2016-01-01

    Objective To explore the pathogenesis of hot flashes,and study the correlation of polymorphism of estrogen metabolic enzyme cytochrome P450 (CYP) gene and hot flashes in the perimenopause women.Methods Totally 328 perimenopausal women were selected randomly for case-control study,including 156 women with hot flashes in the case study group and 172 women without hot flashes in the control group.Follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2) and testosterone (T) were detected by radioimmunoassay.Sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-S) were detected by enzyme linked immunosorbent assay.The gene polymorphisms of CYP17 MspA1 Ⅰ,CYP19 RsaⅠ,CYP1A1MspⅠ and CYP1B1 Eco57Ⅰ were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results The level of FSH was statistically higher,but the levels of E2 and SHBG were statistically lower in the women with hot flashes compared to the women without hot flashes (all P < 0.05).The CYP1B1 Eco57Ⅰ genotype was statistically significant between the women with hot flashes and the women without hot flashes (P < 0.05).The women with CYP1B1 Eco57Ⅰ polymorphism were 1.25 folds in the hot flashes risk (OR =1.25,95% CI =1.03 ~ 1.82),1.28 folds in the severity and 1.35 folds in the duration (persisted for a year or longer) compared to the women without hot flashes.Conclusion Low E2 level may be one of the reasons for hot flashes.Women with CYP1 B1 Eco57Ⅰ polymorphism are more likely to have hot flashes with high severity and long duration.%目的 研究性激素水平及雌激素代谢酶相关基因细胞至色素P450(cytochrome P450,CYP)多态性对围绝经期妇女潮热易感性的影响.方法 选取2006年10月至2008年5月西安交通大学第一附属医院体检中心进行健康体检的328名围绝经期妇女进行病例对照研究,将其分为潮热组(n=156)和无潮热组(n=172).采用放免法

  14. The association of menopause status with physical function: the Study of Women's Health Across the Nation.

    Science.gov (United States)

    Tseng, Lisa A; El Khoudary, Samar R; Young, Elizabeth A; Farhat, Ghada N; Sowers, MaryFran; Sutton-Tyrrell, Kim; Newman, Anne B

    2012-11-01

    The aim of this study was to determine whether postmenopause status is associated with self-reported limitations in physical function. The Study of Women's Health Across the Nation is a multisite, multiethnic, longitudinal study of midlife women. Women aged 45 to 57 years (N = 2,566) completed the physical function scale of the Medical Outcomes Study Short-Form 36 on visit 4 (2000-2001). Scores created a three-category variable of physical function limitations: none (86-100), moderate (51-85), and substantial (0-50). In the Study of Women's Health Across the Nation, menopause status is a five-category list variable based on menstrual bleeding patterns and gynecological surgery. Premenopausal and perimenopausal women using hormones (n = 284) or missing physical function scores (n = 46) were excluded. Multinomial logistic regression was used to relate physical function and menopause status after adjustment for age, ethnicity, site, education, body mass index (BMI), and self-reported diabetes, hypertension, arthritis, depressive symptoms, smoking, and hormone use among postmenopausal women. Of 2,236 women, 8% were premenopausal, 51% were early perimenopausal, 12% were late perimenopausal, 24% were naturally postmenopausal, and 5% were surgically postmenopausal. In the full model, substantial limitations in physical function were higher in postmenopausal women, whether naturally postmenopausal (odds ratio, 3.82; 95% CI, 1.46-10.0) or surgically postmenopausal (odds ratio, 3.54; 95% CI, 1.15-10.84), than in premenopausal women. These associations were attenuated by higher BMI and depressive symptoms but remained significant. Moderate limitations in physical function were not significantly related to menopause status. Women experiencing surgical or naturally occurring postmenopause report greater limitations in physical function compared with premenopausal women, independent of age and only partly explained by higher BMI and depressive symptoms. This suggests that

  15. First time pregnant women's experiences in early pregnancy

    Directory of Open Access Journals (Sweden)

    Modh Carin

    2011-04-01

    Full Text Available Background: There are few studies focusing on women's experiences of early pregnancy. Medical and psychological approaches have dominated the research. Taking women's experiences seriously during early pregnancy may prevent future suffering during childbirth. Aim: To describe and understand women's first time experiences of early pregnancy. Method: Qualitative study using a phenomenological hermeneutic approach. Data were collected via tape-recorded interviews in two antenatal care units in Sweden. Twelve first time pregnant women in week 10–14, aged between 17 and 37 years participated. Results: To be in early pregnancy means for the women a life opening both in terms of life affirming and suffering. The central themes are: living in the present and thinking ahead, being in a change of new perspectives and values and being in change to becoming a mother. Conclusions: The results have implications for the midwife's encounter with the women during pregnancy. Questions of more existential nature, instead of only focusing the physical aspects of the pregnancy, may lead to an improvement in health condition and a positive experience for the pregnant woman.

  16. Prevalence of insomnia and its relationship to menopausal status in middle-aged Korean women.

    Science.gov (United States)

    Shin, Chol; Lee, Sangyeol; Lee, Taewook; Shin, Kyungrim; Yi, Hyeryeon; Kimm, Kuchan; Cho, Namhan

    2005-08-01

    Although the prevalence of insomnia and the association of insomnia with menopause have been well reported, not much work has been conducted in population-based research on insomnia and menopause in Korea. The purpose of the present report was to determine overall and different prevalence of insomnia by menopausal status, and the relationship between insomnia and menopause in a population-based sample of middle-aged Korean women. A total of 96.1% of 2497 randomly selected middle-aged Korean women participated. Insomnia was defined as occurring three times a week or more in the previous month. Subjects were categorized into three groups: premenopause, perimenopause, and postmenopause. The overall prevalence of insomnia in middle-aged Korean women was 14.3%. The most common symptom of insomnia was difficulty maintaining sleep (9.7%), followed by difficulty initiating sleep (7.9%), and early morning awakening (7.5%). Multiple logistic regression analysis revealed that menopause was independently associated with insomnia after adjusting for confounding factors such as age, income, and depression. Perimenopause was significantly associated with a dramatic increase in the risk of insomnia, but there was no significant association for postmenopause. The major finding is that insomnia is significantly associated with the menopausal transition. The prevalence of insomnia increases significantly by the transition from premenopause to perimenopause, but not to postmenopause. A further prospective study is needed to investigate the influence of menopause on insomnia.

  17. 坤泰胶囊对子宫切除术后妇女卵巢功能及围绝经期症状的影响%Effects of Kuntai capsule on ovarian function and perimenopause symptoms of women with hysterectomy

    Institute of Scientific and Technical Information of China (English)

    王红英; 支聪聪; 赵春兰; 姚克文; 王建; 黄瑛; 李友良; 刘淑敏

    2013-01-01

    目的:探讨坤泰胶囊对子宫切除术后妇女卵巢功能及围绝经期症状的影响。方法收集来院就诊142例良性病变切除子宫后应用坤泰胶囊治疗的病例资料,与应用雌激素治疗者做比较。结果2组间E2、FSH、LH水平比较差异有统计学意义(FE2=8.217,PE2=0.000;FFSH=6.727,PFSH=0.000;FLH=5.964,PLH=0.000),其中FSH、LH水平坤泰组均高于激素组;E2水平在治疗3个月后比较差异有统计学意义(t=3.149,P=0.004),坤泰组高于激素组;治疗6个月后水平差异无统计学意义(t=0.892,P=0.611)。不同时间E2、FSH、LH分析表明差异有统计学意义(FE2=7.538,PE2=0.000;FFSH=4.558, PFSH=0.007;FLH=12.148,PLH=0.000),两两比较显示治疗后E2水平升高,FSH、LH水平下降。2组间卵巢体积差异无统计学意义(F=0.018,P=0.895);不同时间卵巢体积差异亦无统计学意义(F=0.112,P=0.798)。2组均未见明显的卵巢血流及窦卵泡变化;2组在改善围绝经期症状总有效率方面差异无统计学意义,坤泰组较激素组乳房胀痛发生例数少,但差异无统计学意义(P>0.05)。结论坤泰胶囊在治疗子宫切除术后患者围绝经期综合征方面有效,为围绝经期综合症患者增加了一种新的选择。%Objective To study the effects of Kuntai Capsule on ovarian function perimenopausal symptoms of women with hysterectomy. Methods 142 cases who suffered from benign diseases with hysterectomy were randomly divided into two groups:Kuntai capsule group and estrogen group. Results There were significant difference between the 2 groups about the levels of E2, FSH and LH (FE2=8.217, PE2=0.000. FFSH=6.727, PFSH=0.000. FLH=5.964, PLH=0.000). While the levels of FSH, LH in Kuntai capsule group were higher than those in estrogen group, the difference were signiifcant. The level of E2 in Kuntai capsule group was higher than that of the estrogen group after 3

  18. Barriers for early detection of cancer amongst Indian rural women

    Directory of Open Access Journals (Sweden)

    Neha Tripathi

    2014-01-01

    Full Text Available Context: Breast and cervical cancer are the most common causes of cancer mortality among women worldwide, but actually they are largely preventable diseases. Healthcare providers in developing countries regularly see women with advanced, incurable cancers. Health of a rural Indian women and her access to health facility is compromised due to sociocultural, economical, and environmental factors. Aims: To know the problems associated with early detection of cancers in rural women. Settings and Design: Rural area and cross-sectional. Subjects and Methods: Study subject: Women of 35 years and above. Exclusion criteria: Not willing to participate. Sample size: All eligible women of selected villages. Sampling Technique: Random selection of villages. Study duration: 2 months. Study tools: Pretested questionnaire. Statistical Analysis Used: Percentages, χ2 test, analysis of variance (ANOVA, multivariate analysis. Results: Awareness about symptoms, possibility of early detection, available tests, possibility of cure of disease was low. Main barrier for screening was cognitive, that is, ′don′t know′ answer by 83.99% women for cancer cervix, 84.93%, for cancer breast, and 67.26% for oral cancer. Awareness score was significantly associated with age (χ2 = 17.77, P = 0.001, education (χ2 = 34.62, P = 0.000, and income (χ2 = 16.72, P = 0.002; while attitude score with age (χ2 = 16.27, P = 0.012 and education (χ2 = 25.16, P = 0.003. Practice score was significantly associated with age (χ2 = 11.28, P = 0.023, education (χ2 = 32.27, P = 0.003, and occupation (χ2 = 10.69, P = 0.03. Awareness, attitude, and practice score of women having history of cancer in family or relative was significantly high than women without history. Conclusions: Cognitive barrier was the important barrier which has to be taken care of.

  19. Abnormal uterine bleeding: a study of menstrual patterns and histopathological patterns in perimenopausal females

    Directory of Open Access Journals (Sweden)

    Mahima Jain

    2015-02-01

    Full Text Available Background: In gynecology out-patient department there is a large group of patients especially in perimenopausal age group who present with various menstrual disorders. These can be as such caused due to various etiologies, which need to be investigated as line of management is thereupon decided. This study is undertaken to know the various abnormal uterine bleeding in perimenopausal women, and their histopathological pattern. Methods: This study is done at PDU medical college hospital, Rajkot, Gujarat which is a tertiary care centre. A retrospective analysis of 268 cases clinically presenting with abnormal uterine bleeding is done. They are further posted for dilatation and curettage after thorough investigation to rule out other pathologies. The endometrial samplings from the D and C material are collected and sent for histopathological assessment. The data is recorded and further analysed. Women between 40-55 years age group are included in this study. Women with diagnosed pelvic pathology, endocrinal cause and bleeding tendencies are excluded from the study. Results: In our study almost all menstrual disorders are found, commonest being menorrhagia in 42.16%. Other patterns reported are metrorrhagia in 3.35%, oligomenorrhea in 14.80%, polymenorrhea and polymenorrhagia in 5.22% and 5.59% cases. Post-menopausal bleeding is found in one case. The histopathological diagnoses reported in this study are proliferative and secretory phase in 26.49% and 19.77% respectively. Other endometrial hyperplasias reported are Swiss cheese in 1.86%, simple cystic hyperplasia in 12.31%, complex hyperplasia with or without atypia in 7% and 4.10% respectively. Malignancy is found in 2 cases. Conclusions: From this study it is well established that endometrial sampling from D and C material still remains the gold standard in diagnosis of various endometrial pathologies in low resource set-up. Thereby the further line of management can also be decided for a

  20. Women in Early British and Irish Astronomy Stars and Satellites

    CERN Document Server

    Brück, Mary

    2009-01-01

    Careers in astronomy for women (as in other sciences) were a rarity in Britain and Ireland until well into the twentieth century. The book investigates the place of women in astronomy before that era, recounted in the form of biographies of about 25 women born between 1650 and 1900 who in varying capacities contributed to its progress during the eighteenth, nineteenth and early twentieth centuries. There are some famous names among them whose biographies have been written before now, there are others who have received less than their due recognition while many more occupied inconspicuous and sometimes thankless places as assistants to male family members. All deserve to be remembered as interesting individuals in an earlier opportunity-poor age. Placed in roughly chronological order, their lives constitute a sample thread in the story of female entry into the male world of science. The book is aimed at astronomers, amateur astronomers, historians of science, and promoters of women in science, but being writte...

  1. Periodontal disease-associated micro-organisms in peri-menopausal and post-menopausal women using or not using hormone replacement therapy. A two-year follow-up study

    Directory of Open Access Journals (Sweden)

    Furuholm Jussi

    2010-04-01

    Full Text Available Abstract Background Despite conflicting results on the use of hormone replacement therapy (HRT there is no doubt that many women benefit from it. Women using HRT are known to be more health conscious in general with putative positive implications in the mouth. However, we observed recently in our cohort hardly any difference in oral health status between HRT-users and non-users. There are only a few studies about HRT and oral microbiota. We hypothesized that counts of periodontal micro-organisms are lower in health-conscious HRT-users than non-users. Methods Two-year open follow-up study was conducted on originally 200 HRT-users and 200 non-users from age cohorts of 50-58 years. After clinical examination pooled subgingival plaque samples were taken for polymerase chain reaction analyses. The results of finally 135 women meeting the inclusion criteria were analyzed with cross-tabulation and chi-square test. Explanatory factors were studied by step-wise logistic regression analysis. Results In HRT group, the numbers of positive samples for Porphyromonas gingivalis (P. gingivalis, p Prevotella intermedia (P. intermedia, p Tannerella forsythia (T. forsythia, p P. gingivalis (p T. forsythia (p Conclusion Although use of HRT did not correlate with periodontal health status, HRT led to decreasing numbers of positive samples of the periodontal pathogens P. gingivalis and T. forsythia. Further studies with longer observation time are needed to observe the clinical relevance of the results.

  2. Caring for women in early labor: can we delay admission and meet women's needs?

    Science.gov (United States)

    Marowitz, Amy

    2014-01-01

    Early labor poses challenges for women and their health care providers. Qualitative research shows that women may have a hard time determining when labor begins and when to seek care, are unprepared for the realities of this part of labor, find it difficult to manage early labor at home, and often desire admission before active labor. Yet a primary clinical management goal in early labor is the delay of admission until active labor. This is based on evidence that admission before active labor is associated with higher rates of cesarean birth and interventions such as oxytocin augmentation and epidural analgesia. The reasons for the higher rates of intervention are not known, but may include the effect of the hospital environment, inherent problems with the labor, misdiagnosis of active labor, provider impatience, and institutional policies not compatible with the care of women in early labor. Programs to decrease early admission have had mixed results. Thus, a tension exists between the goal of delaying admission until active labor in order to decrease the incidence of unnecessary interventions and women's difficulty with managing this part of labor at home. In this case report, the midwife provides a significant amount of care and support before admission through phone calls and outpatient visits; however, admission occurred prior to active labor. Supportive care continued in the hospital, and the labor and birth occurred with little intervention. Strategies that can be used to optimize the management and experience of early labor are presented. © 2014 by the American College of Nurse-Midwives.

  3. Efecto del calcio dietético vs el citrato de calcio sobre marcadores bioquímicos convencionales en mujeres perimenopáusicas Effect of dietary calcium vs. calcium citrate on conventional biochemical markers in perimenopausal women

    Directory of Open Access Journals (Sweden)

    Ma de los Angeles Aguilera-Barreiro

    2005-07-01

    Full Text Available OBJETIVO: Comparación del efecto del citrato de calcio y una dieta con calcio en los alimentos sobre marcadores bioquímicos convencionales. MATERIAL Y MÉTODOS: Se estudiaron 82 mujeres de 30 a 35 años de edad divididas al azar en tres grupos: grupo control: 23 mujeres sin modificación de sus hábitos alimenticios ni actividad física. Grupo con calcio dietético: 28 mujeres con un régimen de 1 000 mg de calcio más actividad física de 30 minutos tres veces por semana. Grupo con citrato de calcio: 31 mujeres suplementadas con citrato de calcio (600 mg, más 500 mg de calcio dietético, y actividad física de 30 minutos tres veces por semana durante siete meses. Se hizo densitometría ósea de calcáneo para clasificarlas en normal y osteopenia, se determinaron parámetros bioquímicos al inicio y final del estudio: fosfatasa alcalina, magnesio, calcio y fósforo séricos, y relación calcio/creatinina en orina. RESULTADOS: El 34% de las mujeres presentaron osteopenia; éstas tuvieron una reducción significativa en el calcio final en el grupo de citrato de calcio en comparación con el grupo de calcio dietético (p0.05. La relación calcio/creatinina fue normal en todos los grupos. CONCLUSIONES: El grupo con calcio dietético presentó mayor formación ósea que el grupo con citrato de calcio; en ninguno de ellos se observó resorción ósea.OBJECTIVE: To compare the effect of calcium citrate and a calcium enriched diet on conventional biochemical markers. MATERIAL AND METHODS: Eighty-two women aged 30 to 35 years were randomized to any of three groups: A control group of 23 women who remained intact in their dietary habits and physical activity; a second group of 28 women who received 1 000 mg of dietary calcium plus physical activity 30 minutes three times per week; and a third group of 31 women who received 600 mg of calcium citrate plus 500 mg of dietary calcium and physical activity three times per week for seven months. Calcaneum

  4. Hubungan Nutrisi Kekerangan Dengan Masa Menopause Pada Wanita Perimenopause

    OpenAIRE

    Sjafaraenan, Dr.

    2013-01-01

    HUBUNGAN NUTRISI KEKERANGAN DENGAN MASA MENOPAUSE PADA WANITA PERIMENOPAUSE Sjafaraenan*, Eddy Soekendarsi*, Rosana Agus*. Irma Andriani* *FMIPA Biologi UNIVERSITAS HASANUDDIN e-mail : ABSTRAK Penelitian tentang hubungan konsumsi kekerangan dengan masa menopause, dilakukan sejak bulan Juni 2013 hingga Agustus 2013, pengamblan sampel dan lokasi penelitian dilakukan di Desa Bonea Kabupaten Muna Sulawesi Tenggara. Tujuan penelitian yaitu: (1) mene...

  5. Accuracy of transvaginal ultrasonography compared to endometrial biopsy for the etiological diagnosis of abnormal perimenopausal bleeding.

    Science.gov (United States)

    Nicula, Renata; Diculescu, Doru; Lencu, Codruţa Claudia; Ciortea, Răzvan; Bucuri, Carmen Elena; Oltean, Ioana Adriana; Trif, Ioana Alexandra; Mihu, Dan

    2017-01-01

    Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management. The study included 103 patients aged between 41.5-55.11 years, divided into 3 age groups: 40-44 years (n=10), 45-49 years (n=54) and ≥50 years (n=39). Certain risk factors of endometrial neoplasm or premalignant conditions were evidenced, their accurate identification being useful in limiting the number of patients with abnormal uterine bleeding (AUB) submitted to diagnostic screening. The most common cause of AUB in our study was fibroma, followed by functional causes. Transvaginal ultrasound (TVUS) represents a minimally invasive method for the screening of perimenopausal patients with AUB, especially to rule out endometrial adenocarcinoma (EAC). TVUS sensitivity was higher than clinical diagnosis in case of leiomioma, polypi and EAC. TVUS was more accurate in the diagnosis of EAC, polypi and leiomioma.

  6. Accuracy of transvaginal ultrasonography compared to endometrial biopsy for the etiological diagnosis of abnormal perimenopausal bleeding

    Science.gov (United States)

    NICULA, RENATA; DICULESCU, DORU; LENCU, CODRUŢA CLAUDIA; CIORTEA, RĂZVAN; BUCURI, CARMEN ELENA; OLTEAN, IOANA ADRIANA; TRIF, IOANA ALEXANDRA; MIHU, DAN

    2017-01-01

    Background and aims Perimenopause is marked by clinical manifestations which disturb everyday life and which may also hide a pathomorphological, more precisely endometrial, substrate. An accurate early diagnosis established by accessible, non-invasive methods is very important for the therapeutic management. Method The study included 103 patients aged between 41.5–55.11 years, divided into 3 age groups: 40–44 years (n=10), 45–49 years (n=54) and ≥50 years (n=39). Results Certain risk factors of endometrial neoplasm or premalignant conditions were evidenced, their accurate identification being useful in limiting the number of patients with abnormal uterine bleeding (AUB) submitted to diagnostic screening. The most common cause of AUB in our study was fibroma, followed by functional causes. Conclusions Transvaginal ultrasound (TVUS) represents a minimally invasive method for the screening of perimenopausal patients with AUB, especially to rule out endometrial adenocarcinoma (EAC). TVUS sensitivity was higher than clinical diagnosis in case of leiomioma, polypi and EAC. TVUS was more accurate in the diagnosis of EAC, polypi and leiomioma. PMID:28246495

  7. Quality of life in perimenopausal women working in the health and educational system Calidad de vida en mujeres climatéricas que trabajan en el sistema sanitario y educativo Qualidade de vida em mulheres climatéricas que trabalham no sistema sanitário e educativo

    Directory of Open Access Journals (Sweden)

    Josefa Márquez Membrive

    2011-12-01

    Full Text Available The objective of this study was to determine the association between the professional activity and the perceived quality of life in climacteric women who work in Health and Education. A descriptive and cross-sectional study was developed in a sample of 203 climacteric women, together with a correlation analysis of labor factors’ influence on health-related quality of life. Significant differences were found between working women’s quality of life and some labor conditions. The perceived quality of life in perimenopausal women who work in Education is higher than that of those working in Health (p=0.004. Nursing professionals can develop health programs that deal with the work conditions that negatively influence the perceived quality of life in climacteric women.El objetivo de este estudio fue determinar la asociación entre la actividad profesional y la calidad de vida percibida en mujeres climatéricas que trabajan en las áreas sanitaria y educativa. Se realizó un estudio descriptivo y transversal, en una muestra de 203 mujeres climatéricas, junto al análisis correlacional de la influencia de los factores laborales en la calidad de vida relacionada con la salud. Se encontraron diferencias significativas entre la calidad de vida de las trabajadoras y algunas condiciones laborales. La calidad de vida percibida por las mujeres perimenopáusicas que trabajan en educación es superior a la de las que trabajan en salud (p=0,004. Los profesionales de Enfermería pueden elaborar programas de salud, que aborden las condiciones de trabajo que influyen negativamente en la calidad de vida percibida por las mujeres climatéricas.O objetivo deste estudo foi determinar a associação entre a atividade profissional e a qualidade de vida percebida em mulheres climatéricas que trabalham nas áreas da saúde e educação. Realizou-se estudo descritivo e transversal, numa amostra de 203 mulheres climatéricas, juntamente com análise correlacional da

  8. Relation of androgen receptor gene polymorphism to bone mineral density and fracture risk in early postmenopausal women during a 5-year randomized hormone replacement therapy trial.

    Science.gov (United States)

    Salmén, Timo; Heikkinen, Anna-Mari; Mahonen, Anitta; Kröger, Heikki; Komulainen, Marja; Pallonen, Heli; Saarikoski, Seppo; Honkanen, Risto; Mäenpää, Pekka H

    2003-02-01

    In women, the influence of androgens on bone health is not clear. It has been suggested that the androgen receptor (AR) genotype is associated with bone mineral density and serum androgen levels in pre- and perimenopausal women, but the association between AR genotype, bone mineral density, and fracture risk has not been studied in postmenopausal women. Therefore, we studied whether AR polymorphism affects bone mineral density, bone mineral density change, or fracture risk in a 5-year randomized hormone replacement therapy (HRT) trial on 331 early postmenopausal women (mean baseline age, 52.7 +/- 2.3 years). The participants consisted of two treatment groups: the HRT group (n = 151) received a sequential combination of 2 mg estradiol valerate and 1 mg cyproterone acetate with or without vitamin D3, 100-300 IU + 93 mg calcium as lactate/day, and the non-HRT group (n = 180) received 93 mg calcium alone or in combination with vitamin D3, 100-300 IU/day for 5 years. Bone mineral density was measured from lumbar spine and proximal femur (DXA) before and after the 5-year trial. All new symptomatic, radiographically defined fractures were recorded during the follow-up. The length of CAG repeat in exon 1 of AR gene was evaluated after polymerase chain reaction (PCR) amplification. The subjects were divided into three repeat groups according to AR alleles. None of the baseline characteristics were associated with AR gene polymorphism and HRT treatment. The polymorphism did not influence the calculated annual changes of lumbar or femoral neck bone mineral density during the 5-year follow-up in the HRT (p = 0.926 and 0.146, respectively) or non-HRT (p = 0.818 and 0.917, respectively) groups. In all, 28 women sustained 33 fractures during the follow-up. Thus, the numbers of fractures were limited. The AR repeat length variation was not significantly associated with fracture risk in the HRT or non-HRT groups (p = 0.632 and 0.459, respectively; Cox proportional hazards model

  9. The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome.

    Science.gov (United States)

    Brooks, H L; Pollow, D P; Hoyer, P B

    2016-07-01

    In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of menopause (ovarian failure in rodents) is a follicle-deplete, ovary-intact animal that more closely approximates the natural human progression through perimenopause and into the postmenopausal stage of life. In this review, we present the physiological parameters of how to use the VCD model and explore the VCD model and its application into the study of postmenopausal disease mechanisms, focusing on recent murine studies of diabetic kidney disease, the metabolic syndrome, and hypertension.

  10. Resilience Factors in Women with Severe Early-Life Maltreatment.

    Science.gov (United States)

    Hillmann, Karen; Neukel, Corinne; Hagemann, Dirk; Herpertz, Sabine C; Bertsch, Katja

    Early-life maltreatment (ELM) has long-lasting negative consequences and is the most important general risk factor for mental disorders. Nevertheless, a number of maltreated children grow up to become healthy adults and have therefore been called 'resilient'. The aim of the current study is to investigate 'resilience factors' in the context of severe ELM. The study was part of the large multicenter project Understanding and Breaking the Intergenerational Cycle of Abuse (UBICA). A total of 89 women were examined, 33 with ELM and at least one lifetime mental disorder (nonresilient), 19 with ELM but without lifetime mental disorders (resilient), and 37 without ELM and without lifetime mental disorders (controls). ELM and other circumstances before the age of 18 years were assessed with the Childhood Experience of Care and Abuse (CECA) Interview. Additional relevant person and situation factors were measured with the Structured Clinical Interview for Mental Disorders (SCID-I), International Personality Disorder Examination (IPDE), Difficulties in Emotion Regulation Scale (DERS), Vulnerable Attachment Style Questionnaire (VASQ), Barratt Impulsiveness Scale (BIS), NEO Five-Factor Inventory (NEO-FFI), and Multiple-Choice Vocabulary Intelligence Test (MWT-B). Factor analyses and paired t tests were performed to identify those variables which differentiate best between the three groups. In addition, a discriminant analysis was conducted to detect the accuracy of assigning women to their specific group. The factor analyses revealed 10 resilience factors based on which we could correctly assign 80% of the women to their group in the discriminant analysis. t tests of factor scores showed that resilient and nonresilient maltreated women mainly differed in current individual attributes (e.g. impulsivity, attachment style), while resilient and nonresilient maltreated women differed from controls in both their current individual attributes and their view of their situation as a

  11. Women, "Star Trek," and the early development of fannish vidding

    Directory of Open Access Journals (Sweden)

    Francesca Coppa

    2008-09-01

    Full Text Available This paper argues that the practices and aesthetics of vidding were structured by the relationship of Star Trek's female fans to that particular televisual text. Star Trek fandom was the crucible within which vidding developed because Star Trek's narrative impelled female fans to take on two positions often framed as contradictory in mainstream culture: the desiring body, and the controlling voice of technology. To make a vid, to edit footage to subtext-revealing music, is to unite these positions: to put technology at the service of desire. Although the conflict between desire and control was particularly thematized in Star Trek, most famously through the divided character of Spock, the practices of vidding are now applied to other visual texts. This essay examines the early history of vidding and demonstrates, through the close reading of particular vids made for Star Trek and Quantum Leap, how vidding heals the wounds created by the displacement and fragmentation of women on television.

  12. [Contraception during the perimenopause: indications, security, and non contraceptive benefits].

    Science.gov (United States)

    Cantero Pérez, P; Klingemann, J; Yaron, M; Irion, N Fournet; Streuli, I

    2015-10-28

    Although patients' fertility is diminished in the period of perimenopause, they still need efficient contraception. Thorough knowledge of the physiological changes occuring during this period of transition is essential in order to provide optimal care. Until the age of 50, no contraceptive method is specifically considered unsuitable due to age alone. The choice of contraceptive needs to be adapted to the patient, assessing the individual risk factors and favouring the potential non-contraceptive advantages of the method selected. Long-term contraceptive methods (e.g., the copper intrauterine device (IUD), the Mirena IUD or a subcutaneous implant) offer an excellent solution on both levels.

  13. "Why Don't I Know about These Women?": The Integration of Early Women Sociologists in Classical Theory Courses

    Science.gov (United States)

    Thomas, Jan E.; Kukulan, Annis

    2004-01-01

    In recent years, early women sociologists such as Harriet Martineau, Ida B. Wells, and Jane Addams have begun to appear in some introductory textbooks and theory books. Usually, they appear in a box, as a sidebar, or as selected "others." So why do we not know more about these women? Our research seeks to answer this question. Given the…

  14. "Why Don't I Know about These Women?": The Integration of Early Women Sociologists in Classical Theory Courses

    Science.gov (United States)

    Thomas, Jan E.; Kukulan, Annis

    2004-01-01

    In recent years, early women sociologists such as Harriet Martineau, Ida B. Wells, and Jane Addams have begun to appear in some introductory textbooks and theory books. Usually, they appear in a box, as a sidebar, or as selected "others." So why do we not know more about these women? Our research seeks to answer this question. Given the…

  15. Misoprostol versus curettage in women with early pregnancy failure after initial expectant management : a randomized trial

    NARCIS (Netherlands)

    Graziosi, GCM; Mol, BWJ; Reuwer, PJH; Drogtrop, A; Bruinse, HW

    2004-01-01

    BACKGROUND: Little is known about the effectiveness of misoprostol treatment in women with early pregnancy failure who have been managed expectantly. We therefore performed a randomized trial on this subject. METHODS: Women with early pregnancy failure, who had been managed expectantly for at least

  16. Time for My Life Now: Early Boomer Women's Anticipation of Volunteering in Retirement

    Science.gov (United States)

    Seaman, Patricia M.

    2012-01-01

    Purpose: This study explored to what extent early Boomer women who work for pay will be interested in and committed to formal volunteering during retirement. Method: Data for this hermeneutic study were gathered through 2 in-depth conversational interviews of 19 English-speaking early Boomer women living in New Brunswick, Canada. Results:…

  17. The relationship between endogenous androgens and body fat distribution in early and late postmenopausal women.

    Directory of Open Access Journals (Sweden)

    Yuankui Cao

    Full Text Available OBJECTIVES: To investigate the relationship between endogenous androgens and body fat distribution in early and late postmenopausal women. MATERIALS AND METHODS: We enrolled postmenopausal women consisting of an early group (≤ 5 years since menopause, n = 105 and a late group (≥ 10 years since menopause, n = 107. Each group was subdivided into normal weight (BMI 0.05.The FT in early postmenopausal women and the DHEA-S levels in late postmenopausal women correlated positively with the trunk/leg fat ratio (T/L and the proportion of android fat whereas correlated negatively with the proportion of gynoid fat in the partial correlation and multiple linear regression analyses (all P<0.05. CONCLUSIONS: Serum T levels do not correlate directly with body fat distribution, the FT in early postmenopausal women and DHEA-S levels in late postmenopausal women correlate positively with abdominal fat accumulation.

  18. Embodied meanings of early childbearing among American Indian women: a turning point.

    Science.gov (United States)

    Palacios, Janelle; Chesla, Catherine; Kennedy, Holly; Strickland, June

    2012-01-01

    American Indian women often have poor perinatal outcomes and are at risk for early childbearing. The purpose of this qualitative study was to understand the experience and meaning of early childbearing among American Indian women. Employing interpretive phenomenology and a semistructured interview guide, we interviewed 30 adult American Indian women residing in a northwestern American Indian reservation about their experiences and meaning of early childbearing. Three overarching themes were tied to their eventual positive evaluation of the experience: 1) mourning a lost childhood, 2) seeking fulfillment, and 3) embodying responsibility. Women indicated that despite their tumultuous childhoods, early childbearing presented an opportunity to effect positive change in their lives. Women's health care providers are positioned to help women change their lives, thereby, improving health outcomes. © 2012 by the American College of Nurse-Midwives.

  19. Increase of tumor necrosis factor receptor 1 expression in women with unexplained early spontaneous abortion

    Institute of Scientific and Technical Information of China (English)

    YAN Chun-fang; YU Xue-wen; JIN Hui; LI Xu

    2004-01-01

    To investigate membrane tumor necrosis factor receptor 1 protein expression level in decidua andconcentration of soluble tumor necrosis factor receptor 1 in serum in women with unexplained early spontaneous abortion,threatened abortion, and compare the levels with healthy pregnant women. Methods: Thirty-seven women with unexplainedearly spontaneous abortion, 27 women with threatened abortion, and 34 healthy pregnant women undergoing artificial abortionof pregnancy at 6 - 10 weeks of gestation were selected. Decidual samples were collected when women were undergoing arti-ficial abortion, and blood samples were collected at the same time. The level of membrane tumor necrosis factor receptor 1 indecidua was detected by flow cytometer, and the concentration of soluble tumor necrosis factor receptor 1 in sera was mea-sured with an enzyme-linked immunosorbent assay. Results: The ercentages of membrane tumor necrosis factor receptor 1positive decidual cells were 16.42 ± 7.10 Mean ± SD for women with unexplained early spontaneous abortion and 13.14 ±6.30 for healthy pregnant women ( P < 0.05). Serum oncentration of soluble tumor necrosis factor receptor 1 was signifi-cantly higher in women with unexplained early spontaneous abortion than in healthy pregnant women and in women withthreatened abortion, and no difference was found between healthy pregnant women and women with threatened abortion.Conclusion: Women with unexplained early spontaneous abortion present significantly higher expression of tumor necrosisfactor receptor 1 than healthy pregnant women, suggesting that over-expression of tumor necrosis factor receptor 1 may cont-ribute to the development of early spontaneous abortion.

  20. Use of vaginal estrogen in Danish women

    DEFF Research Database (Denmark)

    Meaidi, Amani; Goukasian, Irina; Lidegaard, Oejvind

    2016-01-01

    INTRODUCTION: We know little about the use of vaginal estrogen in perimenopausal and postmenopausal women. We aimed to assess the prevalence of vaginal estrogen use in Denmark. MATERIAL AND METHODS: The study was designed as a nationwide cross-sectional study of all Danish women aged 40-79 years,...

  1. The Influence of Early Life Conditions on Social Perceptions of Women in the Workplace

    Directory of Open Access Journals (Sweden)

    Rodgers, Jazmin J.

    2014-09-01

    Full Text Available Women are key contributors to an organizational environment, though the stereotypic perceptions about powerful women are common and often negative. Factors such as wage gap differentials between men and women imply that women are not of the same value to an organization’s success as men. Many empirical studies have examined perceptions about women in positions such as managers, CEOs, supervisors or directors. These studies have not, however, focused on how early life environments, and variables related to an individual’s upbringing, might influence the self-perceptions of these women and the roles they play in the workplace. The purpose of this research is to identify 1 perceptions about women in today’s workplace; 2 how individuals’ early life experiences correlate with their later perceptions about women in the workplace, and 3 how early life influences affect women as organizational leaders in groups and dyads. As such, it is hypothesized that this correlational study will discover that early life conditions, such as the quality of education, household income, and demographic data from both male and female genders will influence common attitudes about women in the workplace. The present research also aims to help employees become more aware of company perceptions and to improve gender communication in the workplace. Examining the workplace perceptions of men and women formed by early life influences, and specifically, researching how women work as leaders in an organizational setting can provide information that will be useful in corporate environments. Significant early life predictors can also be used as data for families and schools raising young women to become leaders in the corporate world.

  2. Effectiveness of a modified version of the applied relaxation technique in treatment of perimenopausal and postmenopausal symptoms.

    Science.gov (United States)

    Saensak, Suprawita; Vutyavanich, Teraporn; Somboonporn, Woraluk; Srisurapanont, Manit

    2013-01-01

    Awareness of the risks associated with hormone therapy for menopausal symptoms has sparked a global decline in this treatment. Alternative treatments to relieve menopausal symptoms are therefore required. The applied relaxation (AR) technique has proven to be successful for symptom amelioration, but requires participation in 12 weekly classes. The purpose of this study was to determine the effectiveness of a modified relaxation version (MR) of AR for treatment of hot flashes, night sweats, and sleep disturbances. We conducted a12-week, randomized, parallel, open-label, controlled trial in perimenopausal and postmenopausal women visiting the menopausal clinic. Participants were randomly assigned to an MR or AR group. The MR group (n=36) received a single session of (MR) training and the AR group (n=35) received conventional 12-week training. Participants were instructed to practice the techniques daily at home for 12 weeks. The main outcome was the measure on the severity scale and frequency of hot flashes, night sweats, and sleep disturbances. All participants completed the study. Total severity scores in both groups decreased after 12 weeks, but there was no difference between the groups (P=0.93). The severity score for hot flashes in the MR group decreased more than in the AR group (P=0.02). The severity scores for night sweats and sleep disturbances decreased in both groups. The frequency of hot flashes, night sweats, and sleep disturbances were also decreased in both groups. A shorter, modified version of the AR was equally effective or slightly better than the conventional AR for the relief of hot flashes, night sweats, and sleep disturbances in perimenopausal and postmenopausal women. Recommendations for future research include confirmatory studies and trials with larger samples.

  3. 安坤汤治疗围绝经期综合征43例临床观察%Clinical observation on forty - three cases with perimenopausal syndrome treated with Ankun decoction

    Institute of Scientific and Technical Information of China (English)

    缪宏珠; 马红雨; 李莹; 董玲; 郝淑娟

    2012-01-01

    Objective: To explore the realistic significance of Ankun decoction in treatment of perimenopausal syndrome from the point of view of tonifying kidney, regulating liver combined with invigorating the circulation of blood. Methods: Forty - three healthy women aged 42 -55 years old with the symptoms of perimenopausal syndrome were selected as study objects, then they were treated with Ankun decoction, one potion per day, and one month was designed as one course, Kupperman scoring was conducted week by week to observe the changes of the symptoms of perimenopausal syndrome; after three courses, the levels of estradiol, follicle stimulating hormone (FSH) , and luteinizing hormone (LH) in blood and the clinical efficacy were monitored to evaluate the effectiveness and safety of Ankun decoction for the women with perimenopausal syndrome. Results; Ankun decoction reduced the Kupperman scores of the women with mild and severe perimenopausal syndrome ( P 0. 05 ) . Conclusion; Ankun decoction can improve the symptoms of perimenopausal syndrome effectively, regulate menstrual cycle of the women with perimenopausal syndrome, not increase the level of estradiol in blood, decrease the level of FSH in blood, so it is a safe and effective prescription for the women with perimenopausal syndrome.%目的:探讨以补肾调肝活血法立论,安坤汤治疗围绝经期综合征的现实意义.方法:43例年龄为42 ~ 55岁出现围绝经期综合征症状的健康妇女作为研究对象,给予口服安坤汤,每日1剂,连续1个月为1个疗程,逐周按Kupperman评分法观察围绝经期症状的变化,3个疗程后监测血雌二醇(E2)、卵泡刺激素(FSH)、黄体生成激素(LH)水平和临床疗效,以评价安坤汤对围绝经期综合征治疗作用的有效性和安全性.结果:安坤汤可显著降低低、中度患者Kupperman评分(P<0.05),对性激素水平有轻度改变,但差异无统计学意义(P>0.05).结论:服用安坤汤可有效地改善围绝经

  4. 围绝经期子宫肌瘤及子宫腺肌病所致异常出血%Perimenopausal abnormal bleeding caused by uterine fibroids and uterine adenomyosis

    Institute of Scientific and Technical Information of China (English)

    汪利群; 黄欧平

    2012-01-01

    Uterine fibroids and adenomyosis is the most common benign gynecological diseases, they are one important reason for abnormal uterine bleeding in perimenopausal period. This article summarizes the e-tiology, diagnosis and treatment of abnormal uterine bleeding caused by fibroids and adenomyosis in perimenopausal women,which should lead to attention.%子宫肌瘤与子宫腺肌病是妇科最常见的良性肿瘤,是导致围绝经期子宫异常出血的重要原因之一.该文概述了子宫肌瘤与子宫腺肌病导致围绝经期异常子宫出血病因、诊断及治疗,以期引起关注.

  5. Tooth counts do not predict bone mineral density in early postmenopausal Caucasian women. EPIC study group

    DEFF Research Database (Denmark)

    Earnshaw, S A; Keating, N; Hosking, D J;

    1998-01-01

    BACKGROUND: It has been suggested that poor dental status may be a suitable criterion for bone densitometry referral in early postmenopausal women. We evaluated this hypothesis in a cohort of 1365 Caucasian women aged between 45 and 59 years, who were enrolled into an international multi-centre t...... loss. Tooth counts therefore cannot be used to identify individuals at risk of osteoporosis....

  6. Decreased arterial elasticity in formerly early-onset preeclamptic women

    NARCIS (Netherlands)

    Souwer, Esteban T. D.; Blaauw, Judith; Coffeng, Sophie M.; Smit, Andries J.; Van Doormaal, Jasper J.; Faas, Marijke M.; Van Pampus, Maria G.

    2011-01-01

    Objective. Preeclampsia is associated with cardiovascular atherosclerotic events later in life. Impaired arterial elasticity is considered to be a marker of vascular (endothelial) dysfunction and to be involved in the atherosclerotic process. We investigated whether previously preeclamptic women hav

  7. An analysis of expectant management in women with early-onset preeclampsia in China.

    Science.gov (United States)

    Chen, Q; Shen, F; Gao, Y F; Zhao, M

    2015-06-01

    Preeclampsia is a pregnancy-specific disorder and a leading cause of morbidity and mortality in both women and fetus. Although women with early severe preeclampsia are generally considered to require expedious delivery, expectant management may benefit for pregnancy prolongation. We performed a retrospective analysis of expectant management in early-onset preeclampsia, with or without fetal grow restriction (FGR) over a 6-year period, to investigate whether these women benefit from expectant management. Data including clinical parameters and liver and renal function from 186 nulliparous women with early-onset preeclampsia were analysed. In women with early-onset preeclampsia, 76.8% were delivered after 48 h and the median pregnancy prolongation was 8 days, whereas 23.2% were delivered within 48 h. There was no difference in maternal parameters, liver or renal functions between women in these two groups, regardless of the severity of preeclampsia. However, the stillbirth number was higher in preeclamptic women delivered after 48 h compared with those delivered within 48 h. Our study demonstrates that the decision for immediate delivery or expectant management was not associated with clinical parameter or laboratory biomarker of liver and renal function. However, the risk of stillbirth should still be taken into consideration when making the decision for immediate delivery or expectant management in the clinic.

  8. Early onset vulvar Lichen Sclerosus in premenopausal women and oral contraceptives.

    Science.gov (United States)

    Günthert, Andreas R; Faber, Melanie; Knappe, Gabriele; Hellriegel, Simin; Emons, Günter

    2008-03-01

    For vulvar Lichen sclerosus (LS) immunological factors, genetic predisposition, and decreased 5 alpha-reductase activity have been discussed as aetiological factors. During the last decade an increase of LS in young women has been suspected. Aim of this study was to evaluate data of premenopausal women with early onset LS to find potential risk factors focussing on the use of oral contraceptives. We retrospectively analyzed the data of 40 premenopausal patients with early onset LS regarding use of oral contraceptives (OCPs), and first occurrence of LS. To compare these data in a case-control study we analyzed a matched control group of 110 healthy women. All our LS patients were using OCPs compared to 73 women (66.4%) in the control group. OCPs with anti-androgenic activity (chlormadinone acetate, cyproterone acetate, dienogest, and drospirenone) were used by 28 (70%) of the LS patients and by 35 (47.9%) of the 73 women using OCPs in the control group. Thus, the odds ratio for early onset LS for women using anti-androgenic OCPs was 2.53 (95% CI: 1.12-5.75). Our data suggest that disturbance of the androgen dependent growth of the vulvar skin by OCPs and especially by OCPs with anti-androgenic properties might trigger the early onset of LS in a subgroup of susceptible young women.

  9. Total and regional body-composition changes in early postmenopausal women

    DEFF Research Database (Denmark)

    Wang, Q; Hassager, C; Ravn, Pernille;

    1994-01-01

    Total and regional body composition were measured in 373 early postmenopausal women aged 49-60 y by dual-energy x-ray absorptiometry to evaluate whether the changes in body composition in the early postmenopausal years are related to menopause itself or merely to age. Both fat mass and fat...

  10. Barriers for Early Detection of Cancer Amongst Urban Indian Women: A Cross Sectional Study

    Science.gov (United States)

    Kadam, Yugantara R.; Quraishi, Sanjay R.; Dhoble, Randheer V.; Sawant, Minaxi R.; Gore, Alka D.

    2016-01-01

    Background: Cancer is a leading cause of death globally. Every year, millions of cancer patients could be saved from premature death and and suffering if they had timely access to early detection and treatment. There are two main components of early detection: early diagnosis and screening. In India, cancers of cervix, breast, mouth/oropharynx are the most frequent cancers in women. These cancers are amenable to early detection. More than two third of the cancer patients are already in an advanced and incurable stage at the time of diagnosis. Objectives: This study was designed with the aim to know the reasons for non availment of cancer screening procedures and early diagnostic facilities. Materials and Methods: This cross-sectional study was planned in Sangli, Miraj and Kupwad Corporation area during October 2013 - March 2014 by a pretested questionnaire. Women of 25 years and above were study subjects selected randomly from a cluster sample of ward with estimated sample size of 559 women. Statistical analysis was done with the help of IBM SPSS 22. Results: Nearly 74% of women said that cancer is curable. For awareness about signs and symptoms, risk factors and screening test 82.3% women scored less than 50% of total score. Only 17.7% women had awareness score more than 50%. But their attitude score was > 50% in 85.2% of women. For practice score, 24.4% women scored > 50%. Significant association was found between awareness, attitude and practice scores and education, occupation and history of cancer in family, friends and neighborhood of respondents. Conclusions: Low awareness is the main barrier for undergoing cancer screening and early detection. There is a need of effective health education programme. PMID:27366310

  11. Early invasive prenatal diagnosis in HBsAg-positive women

    NARCIS (Netherlands)

    P.M. Grosheide (Pia Maria); H.W.P. Quartero (H. W P); S.W. Schalm (Solko); R.A. Heijtink; C.G.M.L. Christiaens

    1994-01-01

    textabstractFrom 1982 to 1989, pregnant women in two large city hospitals in The Netherlands had serum samples screened for hepatitis B surface antigen (HBsAg). Infants of mothers found to be HBsAg-positive received hepatitis B immune globulin immediately after birth and hepatitis B vaccine in the

  12. Early invasive prenatal diagnosis in HBsAg-positive women

    NARCIS (Netherlands)

    P.M. Grosheide (Pia Maria); H.W.P. Quartero (H. W P); S.W. Schalm (Solko); R.A. Heijtink; C.G.M.L. Christiaens

    1994-01-01

    textabstractFrom 1982 to 1989, pregnant women in two large city hospitals in The Netherlands had serum samples screened for hepatitis B surface antigen (HBsAg). Infants of mothers found to be HBsAg-positive received hepatitis B immune globulin immediately after birth and hepatitis B vaccine in the f

  13. Are women in early pregnancy following the national pyramid recommendations?

    LENUS (Irish Health Repository)

    O'Neill, J L

    2011-10-01

    Appropriate nutrition in pregnancy is fundamental for maternal and fetal health, and the long-term physiological wellbeing of the offspring. We aimed to determine whether a sample of pregnant women met the national guidelines for healthy eating during pregnancy, and to examine if compliance differs when analysed by Body Mass Index (BMI) category. Subjects completed a 24-hr dietary recall, and had their BMI calculated. The mean age was 27.8 years. The mean BMI was 25.1 kg\\/m2, with 32 (31.7%) subjects overweight and 14 (13.9%) obese based on BMI category. Although the majority of subjects thought that they had a healthy diet, less than half met the recommended guidelines for each individual food group with achievement of the dairy group being particularly low. Achievement of food group recommendations was not influenced by BMI category. Public health messages on healthy eating guidelines need to be clearly communicated to pregnant women.

  14. Korean Survivors of the Japanese "Comfort Women" System: Understanding the Lifelong Consequences of Early Life Trauma.

    Science.gov (United States)

    Park, Jee Hoon; Lee, KyongWeon; Hand, Michelle D; Anderson, Keith A; Schleitwiler, Tess E

    2016-01-01

    Prior to and during World War II, thousands of girls and young women were abducted from Korea and forced into sexual slavery by the Japanese government. Termed comfort women, these girls and young women suffered extreme sexual, physical, and emotional abuse and trauma. Research on this group is not well-developed and people know little of the impact of this early life trauma on the lives of these women who are now in later life. Using snowball sampling, 16 older adult survivors of the comfort women system participated in semistructured qualitative interviews. Thematic analysis was conducted to gain an understanding of the trauma that these women suffered and how it impacted their lives. Results revealed the depths of the abuse these women suffered, including repeated rapes, physical beatings, humiliation, forced surgery and sterilization, and social exclusion. These early traumatic experiences appeared to reverberate throughout their lives in their family relations, their inability to marry and to conceive children, and their emotional and physical well-being throughout the life course and into later life. The experiences of these survivors illustrate the lasting impact of early-life trauma and can guide interventions with current survivors of sexual abuse or trafficking.

  15. Towards the Early Detection of Breast Cancer in Young Women

    Science.gov (United States)

    2006-10-01

    tissue types. For example, it is difficult to distinguish a ductal carcinoma in-situ from a phyllodes tumor based on E alone (since the ratio is about...cancer, it is less effective in younger women (≤ 40 years), usually because the higher density of their breasts can obscure tumors . While the...to breast cancer detection (see [2] for example) utilizes the fact that breast tumors tend to be significantly stiffer than the surrounding tissue [3

  16. Australian women's prediagnostic decision-making styles, relating to treatment choices for early breast cancer treatment.

    Science.gov (United States)

    Budden, Lea M; Pierce, Penny F; Hayes, Barbara A; Buettner, Petra G

    2003-01-01

    Women diagnosed with early breast cancer are now asked by their doctors to choose from a range of options for their preferred medical treatment plan. Little information is known about women's treatment decision-making and therefore nurses do not have evidence to guide this decision support. The aim of this descriptive survey was to investigate the prediagnostic decision-making behavior of a sample (N = 377) of Australian women, regarding their treatment choices for early breast cancer. The data were collected using the Pre-Decision Portfolio Questionnaire (PDPQ) by Pierce (1996), which includes the Michigan Assessment of Decision Styles (MADS). Of 366 participating women, 19.9% strongly agreed to all three items of the MADS factor Deferring Responsibility; 0.3% strongly agreed to all four factors of Avoidance; 32.7% strongly agreed on all four items of Information Seeking; and 63.4% strongly agreed to all five items of Deliberation. Women showed a variety of preferred decision styles, depending on age, education, occupation and employment status. Only 36% of women indicated it was critically important to "get the treatment over as soon as possible;" 55% to "participate in selecting treatment;" and 53% to "read a lot of information:" The understanding of factors that are important to women when they are making decisions for medical treatment is a mandatory step in designing customized evidence-based decision support, which can be delivered by nurses to help women during this distressing experience.

  17. Cortical porosity exhibits accelerated rate of change in peri- compared with post-menopausal women.

    Science.gov (United States)

    Burt, L A; Bhatla, J L; Hanley, D A; Boyd, S K

    2017-01-10

    The rate of change in bone density was not different between peri- and post-menopausal women. Differences in rate of change were observed in bone microarchitecture, specifically cortical porosity (Ct.Po), where peri-menopausal women increased +9% per year compared with the +6% per year for post-menopausal women.

  18. Patient-Reported Outcomes and Early Discontinuation in Aromatase Inhibitor-Treated Postmenopausal Women With Early Stage Breast Cancer

    Science.gov (United States)

    Kadakia, Kunal C.; Snyder, Claire F.; Kidwell, Kelley M.; Seewald, Nicholas J.; Flockhart, David A.; Skaar, Todd C.; Desta, Zereunesay; Rae, James M.; Otte, Julie L.; Carpenter, Janet S.; Storniolo, Anna M.; Hayes, Daniel F.; Stearns, Vered

    2016-01-01

    Background. Early discontinuation of aromatase inhibitors (AIs) is common and leads to poor outcomes but is challenging to predict. In the Exemestane and Letrozole Pharmacogenetics trial, a high rate of early discontinuation due to intolerance was observed. We hypothesized that early changes in patient-reported outcomes (PROs) predict AI discontinuation and that biochemical factors are associated with changes in PROs. Patients and Methods. Postmenopausal women with early-stage breast cancer enrolled in a prospective randomized trial of exemestane versus letrozole completed questionnaires at baseline and serially over 24 months to assess overall quality of life (EuroQOL Visual Analog Scale [VAS]); mood; and multiple symptoms, including a musculoskeletal symptom cluster. A joint mixed-effects/survival model was used to estimate the effect of the change in PROs on AI discontinuation. Associations between biochemical factors and change in PROs were examined. Results. A total of 490 patients were analyzed. Worsening of EuroQOL VAS and the musculoskeletal cluster were associated with the highest risk for early discontinuation (hazard ratio [HR], 2.77 [95% confidence interval (CI), 2.72–2.81; p = .015]; HR, 4.39 [95% CI, 2.40–8.02; p < .0001], respectively). Pharmacokinetics and estrogen metabolism were not consistently associated with change in PRO measures. No clinically significant differences in any PRO between AIs were observed. Conclusion. Changes in PROs early during AI therapy were associated with treatment discontinuation. Identification of these changes could be used to target interventions in patients at high risk for early discontinuation. Implications for Practice: Early changes in patient-reported outcomes (PROs) can predict nonpersistence to aromatase inhibitor therapy. If used in clinical practice, PROs might identify women at highest risk for early discontinuation and allow for interventions to improve tolerance before significant toxicities develop

  19. Survival after early-stage breast cancer of women previously treated for depression

    DEFF Research Database (Denmark)

    Suppli, Nis Frederik Palm; Johansen, Christoffer; Kessing, Lars Vedel

    2017-01-01

    Purpose The aim of this nationwide, register-based cohort study was to determine whether women treated for depression before primary early-stage breast cancer are at increased risk for receiving treatment that is not in accordance with national guidelines and for poorer survival. Material...... and Methods We identified 45,325 women with early breast cancer diagnosed in Denmark from 1998 to 2011. Of these, 744 women (2%) had had a previous hospital contact (as an inpatient or outpatient) for depression and another 6,068 (13%) had been treated with antidepressants. Associations between previous...... treatment of depression and risk of receiving nonguideline treatment of breast cancer were assessed in multivariable logistic regression analyses. We compared the overall survival, breast cancer-specific survival, and risk of death by suicide of women who were and were not treated for depression before...

  20. [State of immunity to diphtheria and tetanus in women in early postpartum period].

    Science.gov (United States)

    Savis'ko, A A; Kostinov, M P; Kharseeva, G G; Labushkina, A V; Alutina, É L

    2011-01-01

    Study of anti-diphtheria and anti-tetanus immunity in women in early postpartum period depending on age. Women in early postpartum period (n =139) with unknown vaccine anamnesis aged 17 to 44 years and under the supervision of Rostov-on-Don maternity hospital No. 2 were examined for the evaluation of the anti-diphtheria and anti-tetanus immunity state. All the women had high level of protection form these infections. The level of anti-tetanus immunity intensity in the examined was higher than anti-diphtheria. Monitoring of anti-diphtheria and anti-tetanus immunity in women of childbearing age is necessary to resolve the issue of vaccine administration in this group. High level of maternal immunity intensity will allow to form a sufficient protection from infectious agents in neonates.

  1. The Effects of Early first Sexual Intercourse amongst Lesotho Women

    African Journals Online (AJOL)

    AJRH Managing Editor

    Effects of Early Sexual Debut ... Abstract. Age at first sexual intercourse may be a predictor of future sexual behaviour and an important indicator for exposure to HIV transmission. ... technology in mobile phones is improving on a daily basis, children are able to download ... had not received sex education before first sex11.

  2. Do single women value early retirement more than single men?

    DEFF Research Database (Denmark)

    Danø, Anne Møller; Ejrnæs, Mette; Husted, Leif

    2005-01-01

    The focus of this paper is to analyse why a large fraction of single elderly people choose to retire early. A structural model directly based on the individual decision of labour supply is estimated on a sample of singles, where singles are defined as those who are living alone. We find that inco...

  3. The Haemostatic Effects of Mifepristone in Early Pregnant Women

    Institute of Scientific and Technical Information of China (English)

    贺昌海; 范倩; 顾江; 桂幼伦; 汪荣卿; 李盛华; 陈俊康

    1994-01-01

    The paper reported the effects of four different regimens of mifepristone on clotting and fibrinolytic systems in pregnant women. Nine parameters (PT,KPTT,Ⅶ: C, Ⅷ: C, VWF , AT Ⅲ = C, AT Ⅱ = Ag , α2-macroglobulin and plasminogen antigen levels) were determined. All the data were analysed on VAX-Ⅱ using SAS software package, The results showed that among the four groups there was no significant.difference in pretreated values of each parameter, and in values of PT、KPTT、 AT

  4. Migraine in women.

    Science.gov (United States)

    Lay, Christine L; Broner, Susan W

    2009-05-01

    Of the nearly 32 million Americans with migraine, 24 million are women. It is a disorder affecting women throughout their lifetimes, from childhood and puberty through the postmenopausal years. In childhood, before puberty girls are afflicted with migraine at approximately the same rate as boys, but after puberty, there is an emerging female predominance. Estrogen plays a key role in this epidemiologic variation but is not the only factor. There are numerous times when hormonal influences have an impact on migraine and its pattern, including menarche, oral contraceptive use, pregnancy, perimenopause, and menopause. Hence practitioners treating women with migraine need to have a clear understanding of these special considerations.

  5. Prenatal β-Endorphin as an Early Predictor of Postpartum Depressive Symptoms in Euthymic Women

    Science.gov (United States)

    Yim, Ilona S.; Glynn, Laura M.; Schetter, Christine Dunkel; Hobel, Calvin J.; Chicz-DeMet, Aleksandra; Sandman, Curt A.

    2010-01-01

    Background After delivery, many women experience symptoms of postpartum depression (PPD), and early identification of women at risk is therefore important. The opioid peptide β-endorphin has been implicated in non-puerperal depression but its role in the development of PPD is unknown. Methods Three hundred and seven women with a singleton, full-term (>37.0 weeks’ GA) pregnancy were recruited early in pregnancy and followed up into the postpartum period. Blood samples were obtained at 15, 19, 25, 31 and 37 weeks’ gestational age (GA) and at 9 weeks postpartum for assessment of β-endorphin. Depressive symptoms were assessed with the Center for Epidemiological Studies – Depression scale at the last four pregnancy visits and with the Edinburgh Postnatal Depression Scale postpartum. Results Among women who were euthymic at 25 weeks’ GA, those who proceeded to develop PPD symptoms had higher levels of β-endorphin throughout pregnancy compared to women without PPD symptoms (all t > 2.11, p < .05). At each assessment, women above the cut-off score for β-endorphin were at more than three-fold risk for PPD symptoms (odds ratios 3.19 – 4.68) compared to women below the cut-off score. Limitations Self-report of depressive symptoms, no mental health history. Conclusions β-Endorphin may be a useful early predictor of PPD symptoms in women who do not report depressive symptoms in midpregnancy. If replicated, these findings have clinical implications for the identification and treatment of this at risk group and further suggest that some of the pathways leading to this complex disorder may be specific to subgroups of women. PMID:20051292

  6. Prenatal beta-endorphin as an early predictor of postpartum depressive symptoms in euthymic women.

    Science.gov (United States)

    Yim, Ilona S; Glynn, Laura M; Schetter, Christine Dunkel; Hobel, Calvin J; Chicz-Demet, Aleksandra; Sandman, Curt A

    2010-09-01

    After delivery, many women experience symptoms of postpartum depression (PPD), and early identification of women at risk is therefore important. The opioid peptide beta-endorphin has been implicated in non-puerperal depression but its role in the development of PPD is unknown. Three hundred and seven women with a singleton, full-term (>37.0 weeks' GA) pregnancy were recruited early in pregnancy and followed up into the postpartum period. Blood samples were obtained at 15, 19, 25, 31 and 37 weeks' gestational age (GA) and at 9 weeks postpartum for assessment of beta-endorphin. Depressive symptoms were assessed with the Center for Epidemiological Studies-Depression scale at the last four pregnancy visits and with the Edinburgh Postnatal Depression Scale postpartum. Among women who were euthymic at 25 weeks' GA, those who proceeded to develop PPD symptoms had higher levels of beta-endorphin throughout pregnancy compared to women without PPD symptoms (all t>2.11, p<.05). At each assessment, women above the cut-off score for beta-endorphin were at more than three-fold risk for PPD symptoms (odds ratios 3.19-4.68) compared to women below the cut-off score. Self-report of depressive symptoms, no mental health history. Beta-endorphin may be a useful early predictor of PPD symptoms in women who do not report depressive symptoms in mid-pregnancy. If replicated, these findings have clinical implications for the identification and treatment of this at-risk group and further suggest that some of the pathways leading to this complex disorder may be specific to subgroups of women. 2009 Elsevier B.V. All rights reserved.

  7. Early Childbearing among Mexican-American Young Women: Place Matters

    OpenAIRE

    Richardson, Dawn Michele

    2010-01-01

    Compared to all other racial and ethnic groups in the United States, Mexican-American adolescents have by far the highest rates of early childbearing. Within the public health literature, these disproportionately high rates have generally been explored as a function of acculturation, which is described as a process involving the cultural, social, and psychological changes that take place post-migration. In order to elucidate acculturation's effect, specifically on the reproductive health and ...

  8. The immunohistochemical features of chorion and endometrium in women with early pregnancy losses

    Directory of Open Access Journals (Sweden)

    Trohimovych O.V.

    2015-03-01

    Full Text Available Background. According to present views proliferation and apoptosis plays an important role in the mechanisms of placenta formation, particularly in process of vasculogenesis that begins on the third week of pregnancy. Objective: To investigate the immunohistochemical features of chorion and endometrium in women with early pregnancy losses. Methods. 98 samples of abortive and surgical material in pregnant women in terms of 4-10 weeks of pregnancy were analyzed. 48 samples were obtained from women with missed abortion (1st group, 20 samples from women with spontaneous abortion (2nd group; 20 samples from women with tubal pregnancy (3rd group; 10 samples from pregnant women with normal singleton pregnancy, after medical abortion on their own wish (control group. Histological, histochemical and immunohistochemical methods were used. Monoclonal antibodies (MAbs to Ki-67 and bcl-2 were applied. Results. Pathological picture of spontaneous abortion is characterized by the dominance of violation of blood circulation, presence of significant foci of hemorrhage occurring parallel with a pronounced disruption of apoptosis and proliferation in chorionic villi and decidual tissue, leading to the detachment of placenta. Conclusion. In 75% of cases of tubal pregnancy ectopic cytotrophoblast invasion is caused by prominent changes in the structure of the fallopian tube. First of all due to the inflammatory process and a sharp reduction of proliferation in the basal chorion and parietal deciduitis in 65% of cases. Citation: Trohimovych OV. [The immunohistochemical features of chorion and endometrium in women with early pregnancy losses]. Morphologia. 2015;9(1:58-64. Russian.

  9. First-time pregnant women's experiences of their body in early pregnancy.

    Science.gov (United States)

    Bergbom, Ingegerd; Modh, Carin; Lundgren, Ingela; Lindwall, Lillemor

    2016-10-11

    The body of first-time pregnant women is affected in many ways, and the women may not know what to expect. Conversations between women and healthcare personnel about women's bodily experience in early pregnancy can contribute to increased body knowledge, which may have a positive impact in later stages of their pregnancy and in relation to delivery. The aim of the study was to describe first-time pregnant women's experiences of their body in early pregnancy (pregnancy weeks 10-14). Twelve women were asked to draw pictures and answer questions freely about their experiences of their first pregnant body. Hermeneutical text interpretation was used to obtain an overall view of the experiences. A main theme emerged: 'the body is connected to the cycle of life'. This theme comprised five subthemes: 'bodily longing and a sense of ambivalence', 'being doubtful', 'welcoming changes in body and mind', 'feeling inner strength and struggle to find strength' and 'accepting a different body and mind'. This main theme and the subthemes were further interpreted and were understood as an experience of 'me and my body'. The body reminded the women to take care of it and gave rise to positive thoughts. When the body exhibited uncomfortable reactions and sensations, these were taken as evidence of pregnancy, which was also seen positive but it also triggered a sense of dissatisfaction with the body and a feeling of it becoming alien. © 2016 Nordic College of Caring Science.

  10. Timing and indication for curettage after medical abortion in early pregnant women with prior uterine incision.

    Science.gov (United States)

    Wang, Guoyun; Li, Dong; Manconi, Frank; Dong, Baihua; Zhang, Yuncun; Sun, Bingcui

    2010-01-01

    Termination of pregnancy is an important and necessary back-up method for family planning services in many countries. The combination of mifepristone and misoprostol is a widely used alternative to surgical evacuation of the uterus in early pregnancy; however, there are few reports about medical abortion in women with a prior uterine incision and few studies have described curettage occurring as part of the procedure and an indication for the intervention. Curettage in a prior uterine incision can increase operative complications. The purpose of this study was to investigate whether vaginal bleeding intervals, routine ultrasound scan and serum beta-hCG test after medical abortion could accurately identify women with uterine scars who would require curettage. Six hundred sixty-eight women with a uterine scar and at up to 49 days of gestation underwent a medical abortion with mifepristone and misoprostol. Each woman took 50 mg and 25 mg of mifepristone orally in the morning and in the evening, respectively, for 2 days and 600 mcg of misoprostol orally on the third day. Of the 668 women, 6 (0.9%) were lost to follow-up. The overall complete abortion rate was 91.7%; 55 women underwent curettage, including 2 women with heavy bleeding, 3 women with ongoing pregnancy and 34 women with incomplete abortion. The incomplete abortion rate was significantly greater in women with persistent bleeding lasting 21 days than in women with persistent bleeding lasting 14 days (pabortion rate was also greater in women whose serum beta-hCG was >or=500 IU/L than in women whose serum beta-hCG was or=500 IU/L) were 97.1% and 62.5%, respectively. Moreover, the incomplete abortion rate was greater in women with an endometrial thickness >or=15 mm than in women with an endometrial thickness or=15 mm) were 94.1% and 75%, respectively. No complication occurred. The combination of mifepristone and misoprostol was found to be a safe and effective method to terminate early pregnancy in women with a

  11. Moxibustion Reduces Ovarian Granulosa Cell Apoptosis Associated with Perimenopause in a Natural Aging Rat Model

    Directory of Open Access Journals (Sweden)

    Xiao-Lan Shi

    2015-01-01

    Full Text Available In recent years, concerns about the adverse effects of hormone replacement therapy have increased interest in alternative therapies for the management of the symptoms of perimenopause. Here, we investigated the effects of moxibustion, a traditional Chinese practice that is involved in heated Artemisia vulgaris (mugwort stimulation, on hormonal imbalance and ovarian granulosa cell (GC apoptosis in a rat model of perimenopause. Our results showed that mild warm moxibustion (MWM modulated the circulating levels of estradiol and follicle-stimulating hormone and their receptors and inhibited apoptosis in the ovaries of perimenopausal rats, similar to the effect of estrogen. Further investigation revealed that the effects of MWM on ovary tissues and cultured GCs were mediated by the modulation of the activity of Forkhead box protein O1 and involved the JAK2/STAT3 pathway. Our results provide information on the factors and pathways modulated by MWM and shed light on the mechanism underlying the beneficial effect of moxibustion on the symptoms of perimenopause.

  12. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity.

    Science.gov (United States)

    Yin, Fei; Yao, Jia; Sancheti, Harsh; Feng, Tao; Melcangi, Roberto C; Morgan, Todd E; Finch, Caleb E; Pike, Christian J; Mack, Wendy J; Cadenas, Enrique; Brinton, Roberta D

    2015-07-01

    The perimenopause is an aging transition unique to the female that leads to reproductive senescence which can be characterized by multiple neurological symptoms. To better understand potential underlying mechanisms of neurological symptoms of perimenopause, the present study determined genomic, biochemical, brain metabolic, and electrophysiological transformations that occur during this transition using a rat model recapitulating fundamental characteristics of the human perimenopause. Gene expression analyses indicated two distinct aging programs: chronological and endocrine. A critical period emerged during the endocrine transition from regular to irregular cycling characterized by decline in bioenergetic gene expression, confirmed by deficits in fluorodeoxyglucose-positron emission tomography (FDG-PET) brain metabolism, mitochondrial function, and long-term potentiation. Bioinformatic analysis predicted insulin/insulin-like growth factor 1 and adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator 1 alpha (AMPK/PGC1α) signaling pathways as upstream regulators. Onset of acyclicity was accompanied by a rise in genes required for fatty acid metabolism, inflammation, and mitochondrial function. Subsequent chronological aging resulted in decline of genes required for mitochondrial function and β-amyloid degradation. Emergence of glucose hypometabolism and impaired synaptic function in brain provide plausible mechanisms of neurological symptoms of perimenopause and may be predictive of later-life vulnerability to hypometabolic conditions such as Alzheimer's.

  13. Epidemiological survey and analysis of perimenopausal symptoms in Qingdao%青岛地区女性围绝经期症状流行病学调查分析

    Institute of Scientific and Technical Information of China (English)

    初怡静; 王福玲; 娄艳辉; 王箴言; 崔竹梅

    2012-01-01

    Objective: To investigate the prevalence of perimenopausal symptoms and their risk factors in perimenopausal and postmenopausal women in Qingdao urban and suburban district. Methods: 1240 perimenopausal symptom questionnaires were performed in several com-munites from March 2009 to April 2011 in Qingdao, Results: (l)The average menarche age was 15.41 ± 1. 93; average menopause age was 49, 44±3. 27 in 1240 perimenopausal women, (2)The main menopausal symptoms were forgetfulness(76. 6% ) ,loss of libido(72, 9% ) , anor-gasmia(63. 3% ) ,fatigue(59% ). Followed by irritability,sleep disturbances,mood swings,palpitations , vaginal dryness , hot flashes, bone joint and muscle pain, urgency incontinence, dyspa-reunia,paresthesia,dizziness, depression, (3) Major risk factors of perimenopausal symptoms: forgetfulness, anxiety, menopause, sexual life condition, concern about the sexual life, number of children, age,attitude to the menopause (P<0, 05). Conclusions:Most menopausal symptoms suffered by perimenopausal women mostly are mild. Perimenopausal health care should be strengthened, and more attention should be taken to estrogen replace therapy and psychological counseling.%目的:调查青岛地区围绝经期女性围绝经期症状发生情况,并分析其相关危险因素.方法:2009年3月至2011年4月间分层调查青岛市区及近郊各社区1240名围绝经期女性,围绕围绝经期症状进行一般情况问卷调查.结果:(1)1240名围绝经期女性,平均初潮年龄(15.41±1.93)岁;平均绝经年龄(49.44±3.27)岁.(2)围绝经期的主要症状有健忘(76.6%),性欲减退(72.9%),性高潮障碍(63.3%),疲乏(59%);其次为易怒,入睡困难,情绪波动,睡眠障碍,心悸,阴道干燥,潮热,骨、关节、肌肉疼痛,尿急尿失禁,性交痛,皮肤感觉异常,眩晕,抑郁.(3)围绝经期症状的主要危险因素:健忘、焦虑、是否绝经、有无性生活、是否关注性生活、子女数、

  14. Asymptomatic bacteriuria & obstetric outcome following treatment in early versus late pregnancy in north Indian women

    Science.gov (United States)

    Jain, Vaishali; Das, Vinita; Agarwal, Anjoo; Pandey, Amita

    2013-01-01

    Background & objectives: Asymptomatic bacteriuria during pregnancy if left untreated, may lead to acute pyelonephritis, preterm labour, low birth weight foetus, etc. Adequate and early treatment reduces the incidence of these obstetric complications. The present study was done to determine presence of asymptomatic bacteriuria (ASB) and obstetric outcome following treatment in early versus late pregnancy. Methods: A prospective cohort study was conducted at a tertiary care teaching hospital of north India. Pregnant women till 20 wk (n=371) and between 32 to 34 wk gestation (n=274) having no urinary complaints were included. Their mid stream urine sample was sent for culture and sensitivity. Women having > 105 colony forming units/ml of single organism were diagnosed positive for ASB and treated. They were followed till delivery for obstetric outcome. Relative risk with 95% confidence interval was used to describe association between ASB and outcome of interest. Results: ASB was found in 17 per cent pregnant women till 20 wk and in 16 per cent between 32 to 34 wk gestation. Increased incidence of preeclamptic toxaemia (PET) [RR 3.79, 95% CI 1.80-7.97], preterm premature rupture of membrane (PPROM)[RR 3.63, 45% CI 1.63-8.07], preterm labour (PTL) [RR 3.27, 95% CI 1.38-7.72], intrauterine growth restriction (IUGR)[RR 3.79, 95% CI 1.80-79], low birth weight (LBW) [RR1.37, 95% CI 0.71-2.61] was seen in late detected women (32-34 wk) as compared to ASB negative women, whereas no significant difference was seen in early detected women (till 20 wk) as compared to ASB negative women. Interpretation & conclusions: Early detection and treatment of ASB during pregnancy prevents complications like PET, IUGR, PTL, PPROM and LBW. Therefore, screening and treatment of ASB may be incorporated as routine antenatal care for safe motherhood and healthy newborn. PMID:23703344

  15. Asymptomatic bacteriuria & obstetric outcome following treatment in early versus late pregnancy in north Indian women.

    Science.gov (United States)

    Jain, Vaishali; Das, Vinita; Agarwal, Anjoo; Pandey, Amita

    2013-04-01

    Asymptomatic bacteriuria during pregnancy if left untreated, may lead to acute pyelonephritis, preterm labour, low birth weight foetus, etc. Adequate and early treatment reduces the incidence of these obstetric complications. The present study was done to determine presence of asymptomatic bacteriuria (ASB) and obstetric outcome following treatment in early versus late pregnancy. A prospective cohort study was conducted at a tertiary care teaching hospital of north India. Pregnant women till 20 wk (n=371) and between 32 to 34 wk gestation (n=274) having no urinary complaints were included. Their mid stream urine sample was sent for culture and sensitivity. Women having > 10 [5] colony forming units/ml of single organism were diagnosed positive for ASB and treated. They were followed till delivery for obstetric outcome. Relative risk with 95% confidence interval was used to describe association between ASB and outcome of interest. ASB was found in 17 per cent pregnant women till 20 wk and in 16 per cent between 32 to 34 wk gestation. Increased incidence of preeclamptic toxaemia (PET) [RR 3.79, 95% CI 1.80-7.97], preterm premature rupture of membrane (PPROM)[RR 3.63, 45% CI 1.63-8.07], preterm labour (PTL) [RR 3.27, 95% CI 1.38-7.72], intrauterine growth restriction (IUGR)[RR 3.79, 95% CI 1.80-79], low birth weight (LBW) [RR1.37, 95% CI 0.71-2.61] was seen in late detected women (32-34 wk) as compared to ASB negative women, whereas no significant difference was seen in early detected women (till 20 wk) as compared to ASB negative women. Early detection and treatment of ASB during pregnancy prevents complications like PET, IUGR, PTL, PPROM and LBW. Therefore, screening and treatment of ASB may be incorporated as routine antenatal care for safe motherhood and healthy newborn.

  16. Quality of life of Lithuanian women with early stage breast cancer

    OpenAIRE

    Ostapenko Valerijus; Veseliunas Jonas; Bulotiene Giedre

    2007-01-01

    Abstract Background In the last decades, there have been no studies carried out in Lithuania on the quality of life of breast cancer patients. The aim of the present study was to evaluate changes in the quality of life of Lithuanian women with the early stage of breast cancer nine months after surgery and its dependence on surgical strategy, adjuvant chemotherapy and the social and demographic status of the patients. Methods Seventy-seven patients with early stage breast cancer filled in the ...

  17. Effectiveness of a modified version of the applied relaxation technique in treatment of perimenopausal and postmenopausal symptoms

    Directory of Open Access Journals (Sweden)

    Saensak S

    2013-11-01

    Full Text Available Suprawita Saensak,1,2 Teraporn Vutyavanich,3 Woraluk Somboonporn,4 Manit Srisurapanont5 1Academic Department, Faculty of Medicine, Mahasarakham University, Maha Sarakham, 2Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 3Department of Obstetrics and Gynecology, Chiang Mai University, Chiang Mai, 4Department of Obstetrics and Gynecology, KhonKaen University, KhonKaen, 5Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Background: Awareness of the risks associated with hormone therapy for menopausal symptoms has sparked a global decline in this treatment. Alternative treatments to relieve menopausal symptoms are therefore required. The applied relaxation (AR technique has proven to be successful for symptom amelioration, but requires participation in 12 weekly classes. The purpose of this study was to determine the effectiveness of a modified relaxation version (MR of AR for treatment of hot flashes, night sweats, and sleep disturbances. Methods: We conducted a12-week, randomized, parallel, open-label, controlled trial in perimenopausal and postmenopausal women visiting the menopausal clinic. Participants were randomly assigned to an MR or AR group. The MR group (n=36 received a single session of (MR training and the AR group (n=35 received conventional 12-week training. Participants were instructed to practice the techniques daily at home for 12 weeks. The main outcome was the measure on the severity scale and frequency of hot flashes, night sweats, and sleep disturbances. Results: All participants completed the study. Total severity scores in both groups decreased after 12 weeks, but there was no difference between the groups (P=0.93. The severity score for hot flashes in the MR group decreased more than in the AR group (P=0.02. The severity scores for night sweats and sleep disturbances decreased in both groups. The frequency of hot flashes, night sweats, and

  18. Women With Early Menopause Have Higher Rates of Target Lesion Revascularization After Percutaneous Coronary Intervention.

    Science.gov (United States)

    Zhang, Linlin; Wang, Zhijian; Liu, Xiaoli; Zhou, Zhiming; Zhao, Yingxin; Shi, Dongmei; Liu, Yuyang; Liang, Jing; Yang, Lixia; Chai, Meng; Zhou, Yujie

    2016-04-01

    Early menopause has been found to be associated with higher risk of cardiovascular disease. Our objective was to investigate the impact of early menopause on clinical outcomes for women undergoing percutaneous coronary intervention (PCI). We observed female patients with coronary artery disease (CAD) undergoing PCI and found that women with early menopause (≤46 years old) were more likely to have CAD risk factors and more severe coronary lesions. During the 18-month follow-up, early menopause was associated with similar risk of death and myocardial infarction but higher risk of target lesion revascularization (TLR; 7.8% vs 5.3%, P = .003) and major adverse cardiovascular events (MACEs; 11.3% vs 9.0%, P = .007). After adjustment, early menopause was an independent risk factor for 18-month MACEs (hazard ratio [HR], 1.54; 95% confidence interval [CI] 1.18-2.00) and TLR (HR 1.61; 95% CI 1.21-2.13). In conclusion, for women undergoing PCI, early menopause is associated with higher risk of MACE, which is mainly driven by risk of TLR. © The Author(s) 2015.

  19. Antenatal Weight Management: Women's Experiences, Behaviours, and Expectations of Weighing in Early Pregnancy.

    Science.gov (United States)

    Swift, J A; Pearce, J; Jethwa, P H; Taylor, M A; Avery, A; Ellis, S; Langley-Evans, S C; McMullen, S

    2016-01-01

    The current emphasis on obstetric risk management helps to frame gestational weight gain as problematic and encourages intervention by healthcare professionals. However pregnant women have reported confusion, distrust, and negative effects associated with antenatal weight management interactions. The MAGIC study (MAnaging weiGht In pregnanCy) sought to examine women's self-reported experiences of usual-care antenatal weight management in early pregnancy and consider these alongside weight monitoring behaviours and future expectations. 193 women (18 yrs+) were recruited from routine antenatal clinics at the Nottingham University Hospital NHS Trust. Self-reported gestation was 10-27 weeks, with 41.5% (n = 80) between 12 and 14 and 43.0% (n = 83) between 20 and 22 weeks. At recruitment 50.3% of participants (n = 97) could be classified as overweight or obese. 69.4% of highest weight women (≥30 kg/m(2)) did not report receiving advice about weight, although they were significantly more likely compared to women with BMI < 30 kg/m(2). The majority of women (regardless of BMI) did not express any barriers to being weighed and 40.8% reported weighing themselves at home. Women across the BMI categories expressed a desire for more engagement from healthcare professionals on the issue of bodyweight. Women are clearly not being served appropriately in the current situation which simultaneously problematizes and fails to offer constructive dialogue.

  20. Kidney-Tonifying Therapy in Treatment of Perimenopausal Depression%补肾疗法治疗围绝经期抑郁症治验

    Institute of Scientific and Technical Information of China (English)

    孟安琪; 高超; 侯小艳; 李默; 孙剑端; 任路

    2013-01-01

    Perimenopausal depression is a mental illness which often occurs in women before and after menopause 45 to 55 years old.In recent years,due to the increasing social pressure,family burden weight,many women cannot get through this special period,coupled with the interference of external factors,women suffering from perimenopausal depression is increasing which brings influence to many families.Even it is difficult for the patients to maintain the normal life.The author thinks that the pathological basis of perimenopausal depression is deficiency of the kidney.For treating this disease,the kidney-tonifying therapy in the treatment of this disease,by drugs,acupuncture and moxibustion methods to regulate Yin and Yang of kidney so as to help patients to get throuth this period.It has received good clinical curative effect.%围绝经期抑郁症是在围绝经期发生的一种精神疾病,常发生在绝经前后的45~ 55岁,近年来由于社会压力增加,家庭负担增重,许多女性本不能平稳度过这一特殊时期,再加之外界因素干扰,患有围绝经期抑郁症的女性日益增多,给许多家庭带来了重大影响,甚至难以维持正常的生活秩序.作者认为围绝经期抑郁症的病理基础是肾虚,以治病求本为原则,采用补肾疗法治疗本病,通过药物、针刺、艾灸等方法平补肾之阴阳,使更年期女性肾中阴阳平和,达到阴平阳秘的状态,从而帮助患者平稳度过这一时期,收到了良好的临床疗效.

  1. Mental health in early pregnancy is associated with pregnancy outcome in women with pregestational diabetes

    DEFF Research Database (Denmark)

    Callesen, N F; Secher, A L; Cramon, P

    2015-01-01

    AIM: To explore the role of early pregnancy health-related quality of life, anxiety, depression and locus of control for pregnancy outcome in women with pregestational diabetes. METHODS: This was a cohort study of 148 pregnant women with pregestational diabetes (118 with Type 1 diabetes and 30......-Emotional [58.3 (38.1) vs. 82.9 (31.3); P = 0.0005] and Mental Health [67.7 (20.4) vs. 75.2 (15.8), P = 0.04], and a lower score for the 36-item Short-Form Health Survey scale Mental Component Summary (42.8 (13.1) vs. 48.8 (9.7), P = 0.03) in early pregnancy, compared with women with term deliveries. Depression...... symptoms (Hospital Anxiety and Depression Scale depression score ≥ 8) were more frequent in women with preterm vs. term deliveries (seven (25%) vs. six women (5%); P = 0.003), while levels of anxiety and locus of control were similar in these two groups. No difference in early pregnancy scores for health...

  2. Relationship between renal histology and plasma antithrombin III activity in women with early onset preeclampsia.

    Science.gov (United States)

    Weiner, C P; Bonsib, S M

    1990-04-01

    Renal biopsy was performed in 12 women with the clinical diagnosis of severe, early-onset preeclampsia at the time of cesarean delivery for the express purpose of aiding future counseling on the risk of recurrence. The mean gestation at delivery was 30 +/- 3 weeks. The mean birthweight was 1090 +/- 505 gm. Four women (33%) were multiparous. Antithrombin III activity was determined immediately prior to delivery unrelated to clinical care and as part of other protocols. The biopsy was performed without difficulty in each, although the sample was inadequate in one patient. The clinical diagnosis of preeclampsia was confirmed in nine (82%). However, three of the nine had underlying renal disease, as did the two women without histologic evidence of preeclampsia (42% of the total). Correlations between laboratory parameters with the histopathologic diagnoses were sought. Neither uric acid, creatinine, blood urea nitrogen, platelet count, or 24-hour urinary protein measurements aided the differentiation of the various subgroups. Antithrombin III activity in women with biopsy-supported preeclampsia (77% +/- 12%) was significantly lower than that in women without histologic evidence of preeclampsia (116% +/- 8%). Antithrombin III activity correctly predicted biopsy findings in at least 9 of 11 (82%). These preliminary findings confirm the high frequency of underlying disease in women with early-onset preeclampsia. Although low antithrombin III activity does not differentiate between "pure" preeclampsia and superimposed disease, a normal antithrombin III activity is reassuring and more consistent with a nonpreeclamptic renal complication than with preeclampsia.

  3. Early pregnancy plasminogen activator inhibitor-1 levels in Nigerian women and its relationship with preeclampsia.

    Science.gov (United States)

    Udenze, I C; Arikawe, A P; Makwe, C C

    2017-05-01

    This study compared early plasma levels of plasminogen activator inhibitor-1 (PAI-1) in normal pregnancy and preeclampsia and determined its relationship with disease severity. This was a prospective cohort study of 195 normotensive, aproteinuric pregnant women without prior history of gestational hypertension. The women were attending the Antenatal Clinic at The Lagos University Teaching Hospital and were within 24 weeks gestation at recruitment. The outcome measures were PAI-1, systolic blood pressure (SBP), diastolic blood pressure (DBP), and significant proteinuria. The endpoint of the study was the development of preeclampsia. The diagnosis of preeclampsia was made by the attending Obstetrician. The data were analyzed using the IBM SPSS statistical software. Statistical significance was set at P women who later developed preeclampsia compared to those who had a normal pregnancy (P women who later developed preeclampsia, PAI-1 had an inverse relationship with gestational age (r = 0.878) whereas in normal pregnancy, PAI-1 and gestational age had a direct relationship (r = 0.017). Second trimester systolic and DBP values were also significantly higher in the women who later developed preeclampsia compared to normal pregnancy, P = 0.007 and 0.004, respectively. There was, however, no correlation between PAI-1 values and SBP, DBP and proteinuria in the women who developed preeclampsia. Plasma levels of PAI-1 are increased early in pregnancies complicated by preeclampsia, but the lack of correlation of this marker with disease severity may limit its clinical utility.

  4. Child Abuse, Early Maladaptive Schemas, and Risky Sexual Behavior in College Women

    Science.gov (United States)

    Roemmele, Melissa; Messman-Moore, Terri L.

    2011-01-01

    Previous research suggests that individuals abused as children are more likely to engage in risky sexual behavior during adulthood. The present study examined early maladaptive schemas as mediators of the child abuse-risky sexual behavior relationship among 653 college women. Self-report surveys assessed three forms of child abuse: Sexual,…

  5. Exercise Effects on Fitness and Bone Mineral Density in Early Postmenopausal Women: 1-Year EFOPS Results.

    Science.gov (United States)

    Kemmler, Wolfgang; Engelke, Klaus; Lauber, Dirk; Weineck, Juergen; Hensen, Johannes; Kalender, Willi A.

    2002-01-01

    Investigated the effect of intense exercise training on physical fitness, coronary heart disease, bone mineral density (BMD), and parameters related to quality of life in early postmenopausal women with osteopenia. Data on woman in control and exercise training groups indicated that the intense exercise training program was effective in improving…

  6. The benefit of early treatment without rescreening in women with a history of gestational diabetes.

    LENUS (Irish Health Repository)

    Maher, Nicola

    2013-02-01

    In this center, women with a history of gestational diabetes (GDM) are treated without rescreening from early pregnancy in any subsequent pregnancies, commencing with a low glycemic diet and insulin if and when indicated. The objective of this study was to see if this practice reduced the incidence of macrosomia compared with the index pregnancy.

  7. Child Abuse, Early Maladaptive Schemas, and Risky Sexual Behavior in College Women

    Science.gov (United States)

    Roemmele, Melissa; Messman-Moore, Terri L.

    2011-01-01

    Previous research suggests that individuals abused as children are more likely to engage in risky sexual behavior during adulthood. The present study examined early maladaptive schemas as mediators of the child abuse-risky sexual behavior relationship among 653 college women. Self-report surveys assessed three forms of child abuse: Sexual,…

  8. Postexercise nutrient intake enhances leg protein balance in early postmenopausal women

    DEFF Research Database (Denmark)

    Holm, Lars; Esmarck, B.; Suetta, C.

    2005-01-01

    Background. We investigated the effect of nutrient administration after a session of resistance exercise on muscle protein kinetics in six healthy, early postmenopausal women, in a crossover design of random and double-blinded administration of protein and carbohydrate (PC) or placebo (NON).Metho...

  9. Postexercise nutrient intake enhances leg protein balance in early postmenopausal women

    DEFF Research Database (Denmark)

    Holm, Lars; Esmarck, Birgitte; Suetta, Charlotte

    2005-01-01

    BACKGROUND: We investigated the effect of nutrient administration after a session of resistance exercise on muscle protein kinetics in six healthy, early postmenopausal women, in a crossover design of random and double-blinded administration of protein and carbohydrate (PC) or placebo (NON). METH...

  10. Early Pubertal Timing and the Union Formation Behaviors of Young Women

    Science.gov (United States)

    Cavanagh, Shannon E.

    2011-01-01

    This study examined whether the transition into adolescence, proxied by pubertal timing, shaped the transition into adulthood, proxied by union formation behaviors, among contemporary American women. In a sample drawn from Add Health (n = 7,523), early maturing girls reported an accelerated transition to marriage and cohabitation in young…

  11. The Exploration on the Safety of Intrauterine Device Retention During Perimenopausal Period%围绝经期宫内节育器滞留的安全性探讨

    Institute of Scientific and Technical Information of China (English)

    李桂玲

    2013-01-01

    Objective To research the safety of intrauterine device retention during perimenopausal period. Methods The form of questionnaire was used to investigate women in perimenopausal period in this district. We selected 300 women using intrauterine device as observing group and 300 using other contraceptive methods. Not using intrauterine device ) as control group. The enrolled subjects were given consultation and health examination and the menstruation state waist and abdomen's pain and the occurrence of gynecological inflammation were compared between two groups. Results There was no statistically significant difference in the menstrual blood volume of women in perimenopausal period between two groups (P>0.05).There was statistically significant difference in the incidence of pain in waist or abdomen in women in perimenopausal period between two groups (P<0.05). The incidence of gynecological inflammation in women in perimenopausal period was 63.33%and 59.67%in the observing group and control group respectively and there was no statistically significant difference between two groups. Conclusion Intrauterine device retention during perimenopausal period has no impact on women' menstruation state and gynecological inflammation,but is relevant with waist and abdomen's pain.%目的探讨女性围绝经期宫内节育器滞留的的安全性问题.方法采用调查问卷形式在本区对围绝经期女性进行调查,抽取300例使用宫内节育器的女性作为观察组,300例使用其他避孕方式(即未使用宫内节育器)的女性作为对照组,并对其进行咨询和健康检查,比较两组女性的月经情况、围绝经期腰腹部疼痛情况及妇科炎症的发生情况.结果观察组围绝经期女性月经量少、中、多的发生率和对照组比较,差异无统计学意义(P>0.05);观察组围绝经期腰腹部疼痛无症状、轻症、中症、重症的发生率和对照组比较,差异有统计学意义(P<0

  12. No relation between folate and homocysteine levels and depression in early pregnant women.

    Science.gov (United States)

    Watanabe, Hiroko; Suganuma, Nobuhiko; Hayashi, Ayako; Hirowatari, Yumiko; Hirowatari, Tsuneharu; Ohsawa, Masami

    2010-12-01

    The objective in this study was to evaluate the association between folate and homocysteine (Hcy) levels and depressive symptoms in early pregnancy. A cross-sectional study was conducted with 86 pregnant women in the first trimester. A Japanese version of the Center for Epidemiologic Studies Depression (CES-D) scale was used to screen for depression. Non-fasting blood samples were collected from the women to measure folate and Hcy levels. Fifty-three (61.6%) women scored at or above a clinical cut-off of 16, and were classified with depression. In logistic regression analyses, no significant associations were observed between the incidence of depression in the first trimester and elevated Hcy and deficiencies of serum folate, folate intake, vitamin B6 intake and vitamin B12 intake. Folate and Hcy concentrations, and folate consumption, may not be protective against depression in early pregnancy.

  13. Assessment of noninvasive, percutaneous hemoglobin measurement in pregnant and early postpartum women

    Directory of Open Access Journals (Sweden)

    Yoshida A

    2014-01-01

    Full Text Available Atsushi Yoshida,1 Keiko Saito,2 Kenji Ishii,2 Isao Azuma,2 Hidenori Sasa,1 Kenichi Furuya11Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Japan; 2Department of Obstetrics and Gynecology, Nishisaitama-Chuo National Hospital, Tokorozawa, JapanPurpose: Using the Pronto-7® analyzer, we measured percutaneous hemoglobin (SpHb noninvasively in pregnant and early postpartum women, and assessed the accuracy of the measurements by comparing them with laboratory measurements of hemoglobin.Methods: We obtained SpHb measurements from 193 pregnant women, 269 early postpartum women, and 76 nonpregnant women. A laboratory total hemoglobin (tHb measurement, from venous blood sampling, was obtained immediately prior to the SpHb measurement. The total number of measurements obtained from the nonpregnant, pregnant, and postpartum women was 76, 438, and 347, respectively.Results: The mean biases (SpHb - tHb among the nonpregnant, first trimester, second trimester, third trimester, and early postpartum women were -0.20, 0.19, 1.01, 1.32, and 1.10 g/dL, respectively. The Bland-Altman comparison showed neither the tendency of a fixed bias nor proportional biases among the measurements in the category of nonpregnant and first trimester women. But in the second and third trimester and postpartum category, a significant fixed bias was noted, without any tendencies of proportional bias.Conclusion: In this study, we found higher hemoglobin values with the Pronto-7 analyzer than were measured in the laboratory. We consider that the device has certain limitations in obstetrical utility and requires further modifications for use in the perinatal period.Keywords: anemia, pregnancy, hemoglobin, noninvasive

  14. Early Phthalates Exposure in Pregnant Women Is Associated with Alteration of Thyroid Hormones

    Science.gov (United States)

    Tsai, Chih-Hsin; Liang, Wei-Yen; Li, Sih-Syuan; Huang, Han-Bin

    2016-01-01

    Introduction Previous studies revealed that phthalate exposure could alter thyroid hormones during the last trimester of pregnancy. However, thyroid hormones are crucial for fetal development during the first trimester. We aimed to clarify the effect of phthalate exposure on thyroid hormones during early pregnancy. Method We recruited 97 pregnant women who were offered an amniocentesis during the early trimester from an obstetrics clinic in southern Taiwan from 2013 to 2014. After signing an informed consent form, we collected amniotic fluid and urine samples from pregnant women to analyze 11 metabolites, including mono-ethyl phthalate (MEP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-(2-ethylhexyl) phthalate (MEHP), mono-butyl phthalate (MnBP), of 9 phthalates using liquid chromatography/ tandem mass spectrometry. We collected blood samples from each subject to analyze serum thyroid hormones including thyroxine (T4), free T4, and thyroid-binding globulin (TBG). Results Three phthalate metabolites were discovered to be >80% in the urine samples of the pregnant women: MEP (88%), MnBP (81%) and MECPP (86%). Median MnBP and MECPP levels in pregnant Taiwanese women were 21.5 and 17.6 μg/g-creatinine, respectively, that decreased after the 2011 Taiwan DEHP scandal. Results of principal component analysis suggested two major sources (DEHP and other phthalates) of phthalates exposure in pregnant women. After adjusting for age, gestational age, TBG, urinary creatinine, and other phthalate metabolites, we found a significantly negative association between urinary MnBP levels and serum T4 (β = –5.41; p-value = 0.012; n = 97) in pregnant women using Bonferroni correction. Conclusion We observed a potential change in the thyroid hormones of pregnant women during early pregnancy after DnBP exposure. Additional study is necessitated to clarify these associations. PMID:27455052

  15. Early Phthalates Exposure in Pregnant Women Is Associated with Alteration of Thyroid Hormones.

    Directory of Open Access Journals (Sweden)

    Po-Chin Huang

    Full Text Available Previous studies revealed that phthalate exposure could alter thyroid hormones during the last trimester of pregnancy. However, thyroid hormones are crucial for fetal development during the first trimester. We aimed to clarify the effect of phthalate exposure on thyroid hormones during early pregnancy.We recruited 97 pregnant women who were offered an amniocentesis during the early trimester from an obstetrics clinic in southern Taiwan from 2013 to 2014. After signing an informed consent form, we collected amniotic fluid and urine samples from pregnant women to analyze 11 metabolites, including mono-ethyl phthalate (MEP, mono-(2-ethyl-5-carboxypentyl phthalate (MECPP, mono-(2-ethylhexyl phthalate (MEHP, mono-butyl phthalate (MnBP, of 9 phthalates using liquid chromatography/ tandem mass spectrometry. We collected blood samples from each subject to analyze serum thyroid hormones including thyroxine (T4, free T4, and thyroid-binding globulin (TBG.Three phthalate metabolites were discovered to be >80% in the urine samples of the pregnant women: MEP (88%, MnBP (81% and MECPP (86%. Median MnBP and MECPP levels in pregnant Taiwanese women were 21.5 and 17.6 μg/g-creatinine, respectively, that decreased after the 2011 Taiwan DEHP scandal. Results of principal component analysis suggested two major sources (DEHP and other phthalates of phthalates exposure in pregnant women. After adjusting for age, gestational age, TBG, urinary creatinine, and other phthalate metabolites, we found a significantly negative association between urinary MnBP levels and serum T4 (β = -5.41; p-value = 0.012; n = 97 in pregnant women using Bonferroni correction.We observed a potential change in the thyroid hormones of pregnant women during early pregnancy after DnBP exposure. Additional study is necessitated to clarify these associations.

  16. Health education for early detection of breast cancer in blind women

    Directory of Open Access Journals (Sweden)

    Inacia Sátiro Xavier de França

    2015-12-01

    Full Text Available Objective: to assess the knowledge of blind women about the risk factors for breast cancer and whether they look for early detection of this cancer. Methods: a quasi-experimental study with 72 blind women distributed in focus groups. Data were collected through interviews. Results: few participants had knowledge about one or more risk factors for breast cancer, but most practiced early detection. Health education was developed using breast kits and demonstration of breast self-examination. It was obtained qualitative improvement of knowledge of the participants about breast cancer, its risk factors and early detection practices. In addition, participants demonstrated breast self-examination confidently. Conclusion: we need to develop in a harder manner educational activities to clarify about breast cancer risk factors and the importance of periodically carrying out breast self-examination, clinical examination and mammography.

  17. Oxidative Stress: An Effective Prognostic Tool for an Early Detection of Cardiovascular Disease in Menopausal Women

    Directory of Open Access Journals (Sweden)

    Jyot Amrita

    2016-01-01

    Full Text Available Background. Menopause, a form of reproductive aging, is marked by many hormonal variations which cause imbalance in the oxidative processes resulting in onset of endothelial dysfunction leading to cardiovascular disease (CVD. We aimed to analyze the effect of oxidative stress in an early detection of CVD in all menopausal women both normolipidemic and hyperlipidemic. Methods and Results. Study included 523 menopausal women (265 CVD and 258 non-CVD. They were screened for lipid profile, serum malondialdehyde (MDA, serum LDL carbonyl protein, and serum superoxide dismutase (SOD. Pearson’s correlation was observed between MDA and atherogenic index of plasma (AIP in both normolipidemic (r=0.650; p<0.001 and hyperlipidemic (r=0.207; p<0.01 CVD group as compared to non-CVD menopausal women. Significant correlation was also observed between LDL carbonyl content and AIP in normolipidemic (r=0.650; p<0.001 and hyperlipidemic (r=0.248; p<0.01 CVD menopausal women as compared to non-CVD ones. Conclusion. Strong correlation between atherogenic index of plasma and oxidative stress in CVD menopausal women reveals oxidative stress as an effective prognostic tool for an early detection of cardiovascular risk.

  18. Vitamin D and bone health in postmenopausal women.

    Science.gov (United States)

    Malabanan, Alan O; Holick, Michael F

    2003-03-01

    Osteoporosis, a disease of increased skeletal fragility, is becoming increasingly common as the U.S. population ages. Adequate vitamin D and calcium intake is the cornerstone of osteoporosis prevention and treatment. Age-related changes in vitamin D and calcium metabolism increase the risk of vitamin D insufficiency and secondary hyperparathyroidism. Although longitudinal data have suggested a role of vitamin D intake in modulating bone loss in perimenopausal women, studies of vitamin D and calcium supplementation have failed to support a significant effect of vitamin D and calcium during early menopause. There is a clearer benefit in vitamin D and calcium supplementation in older postmenopausal women. Vitamin D intake between 500 and 800 IU daily, with or without calcium supplementation, has been shown to increase bone mineral density (BMD) in women with a mean age of approximately 63 years. In women older than 65, there is even more benefit with vitamin D intakes of between 800 and 900 IU daily and 1200-1300 mg of calcium daily, with increased bone density, decreased bone turnover, and decreased nonvertebral fractures. The decreases in nonvertebral fractures may also be influenced by vitamin D-mediated decreases in body sway and fall risk. There are insufficient available data supporting a benefit from vitamin D supplementation alone, without calcium, to prevent osteoporotic fracture in postmenopausal women.

  19. Perimenopausal vaginal bleeding caused by endometrial lesions%围绝经期子宫内膜病变所致阴道流血

    Institute of Scientific and Technical Information of China (English)

    梁海燕; 凌斌

    2012-01-01

    For perimenopausal women, abnormal u-terine bleeding mostly resulted from endometrial disorders including dysfunctional uterine bleeding, endometrial polyp, endometritis, endometrial hyperplasia and endometrial cancer. This article summarized the salient literature on the etiology, pathology, diagnosis and management of these disorders or introduced some improvements.%围绝经期异常子宫出血的主要原因之一是子宫内膜病变,包括功能失调性子宫出血、子宫内膜炎、子宫内膜息肉、子宫内膜增殖症和子宫内膜癌等.该文总结了这些疾病的病因、病理、诊断和治疗以及相关的研究进展.

  20. Breast Cancer Awareness and Prevention Behavior Among Women of Delhi, India: Identifying Barriers to Early Detection

    Science.gov (United States)

    Dey, Subhojit; Sharma, Surabhi; Mishra, Arti; Krishnan, Suneeta; Govil, Jyotsna; Dhillon, Preet K.

    2016-01-01

    BACKGROUND Globally, breast cancer (BC) has become the leading cause of mortality in women. Awareness and early detection can curb the growing burden of BC and are the first step in the battle against BC. The aim of this qualitative study was to explore the awareness and perceived barriers concerning the early detection of BC. METHODS A total of 20 focus group discussions (FGDs) were conducted during May 2013–March 2014. Pre-existing themes were used to conduct FGDs; each FGD group consisted of an average of ~10 women (aged ≥18–70 years) who came to participate in a BC awareness workshop. All FGDs were audio taped and transcribed verbatim. The transcripts were inductively analyzed using ATLAS.ti. Based on emerged codes and categories, thematic analysis was done, and theory was developed using the grounded theory approach. RESULTS Data were analyzed in three major themes: i) knowledge and perception about BC; ii) barriers faced by women in the early presentation of BC; and iii) healthcare-seeking behavior. The findings revealed that shyness, fear, and posteriority were the major behavioral barriers in the early presentation of BC. Erroneously, pain was considered as an initial symptom of BC by most women. Financial constraint was also mentioned as a cause for delay in accessing treatment. Social stigma that breast problems reflect bad character of women also contributed in hiding BC symptoms. CONCLUSIONS Lack of BC awareness was prevalent, especially in low socioeconomic class. Women’s ambivalence in prioritizing their own health and social and behavioral hurdles should be addressed by BC awareness campaigns appropriately suited for various levels of social class.

  1. Robotic-assisted laparoscopic hysterectomy seems safe in women with early-stage endometrial cancer

    DEFF Research Database (Denmark)

    Herling, Suzanne Forsyth; Havemann, Maria Cecilie; Palle, Connie

    2015-01-01

    . The overall incidence of complications was 15%, also with no significant difference between groups (p = 0.32). The most frequent complications were urinary tract infections (6%) and port site/wound infections (3%). A total of 21% of the women who had lymphadenectomy developed lymphoedema within 12 months....... CONCLUSION: The types and frequency of complications observed in this study resemble those reported in similar studies of RALH for malignant gynaecologic conditions. Health-care professionals treating and caring for women with early-stage endometrial cancer should know of the types and frequency of post...

  2. Predictors of early breastfeeding cessation among HIV-infected women in Botswana.

    Science.gov (United States)

    Ogwu, Anthony; Moyo, Sikhulile; Powis, Kathleen; Asmelash, Aida; Lockman, Shahin; Moffat, Claire; Leidner, Jean; Makhema, Joseph; Essex, Max; Shapiro, Roger

    2016-08-01

    Infants born to HIV-infected women receiving antiretroviral treatment (ART) can be breastfed through at least 6 months with very low risk of HIV acquisition. We aimed to identify demographic and cultural factors that may influence mothers' willingness to breastfeed for the recommended duration. We evaluated factors associated with early cessation of breastfeeding (i.e. before 5 months post-partum) in a randomized clinical trial evaluating different ART regimens used for prevention of mother-to-child transmission during breastfeeding in Botswana. Univariate and multivariable Cox regressions were used to describe predictors of early exclusive BF cessation. Among 677 women who started breastfeeding, the median time to breastfeeding cessation was 178 days (IQR 150-181) and 25.1% weaned early. In multivariable analysis, urban location (aHR = 1.86 95%CI 1.27-2.73; P = 0.002), salaried employment or being a student (aHR = 2.78 95% CI 1.63-4.75; P < 0.001) and infant hospitalisation before weaning (aHR = 2.04 95% CI 1.21-3.45; P = 0.008) were independently and significantly associated with early BF cessation. Improved support for breastfeeding among employed mothers, especially in urban settings, may allow HIV-infected women who are receiving ART prophylaxis to breastfeed longer. © 2016 John Wiley & Sons Ltd.

  3. Menopause Experiences and Attitudes in Women with Intellectual Disability and in Their Family Carers

    Science.gov (United States)

    Chou, Yueh-Ching; Lu, Zxy-Yann Jane; Pu, Cheng-Yun

    2013-01-01

    Background: Little is known about how middle-aged and older women with intellectual disability (ID) cope with life transitions such as perimenopause and postmenopause. Method: A mixed methods approach was employed to explore the attitudes toward and experiences of menopause among women with ID and their family carers in one city in Taiwan.…

  4. Menopause Experiences and Attitudes in Women with Intellectual Disability and in Their Family Carers

    Science.gov (United States)

    Chou, Yueh-Ching; Lu, Zxy-Yann Jane; Pu, Cheng-Yun

    2013-01-01

    Background: Little is known about how middle-aged and older women with intellectual disability (ID) cope with life transitions such as perimenopause and postmenopause. Method: A mixed methods approach was employed to explore the attitudes toward and experiences of menopause among women with ID and their family carers in one city in Taiwan.…

  5. Early risk factors for miscarriage: a prospective cohort study in pregnant women.

    Science.gov (United States)

    Arck, Petra C; Rücke, Mirjam; Rose, Matthias; Szekeres-Bartho, Julia; Douglas, Alison J; Pritsch, Maria; Blois, Sandra M; Pincus, Maike K; Bärenstrauch, Nina; Dudenhausen, Joachim W; Nakamura, Katrina; Sheps, Sam; Klapp, Burghard F

    2008-07-01

    Many pregnancies are lost during early gestation, but clinicians still lack tools to recognize risk factors for miscarriage. Thus, the identification of risk factors for miscarriage during the first trimester in women with no obvious risk for a pregnancy loss was the aim of this prospective cohort trial. A total of 1098 women between gestation weeks 4 and 12 in whom no apparent signs of a threatened pregnancy could be diagnosed were recruited. Demographic, anamnestic, psychometric and biological data were documented at recruitment and pregnancy outcomes were registered subsequently. Among the cases with sufficiently available data, 809 successfully progressing pregnancies and 55 subsequent miscarriages were reported. In this cohort, risk of miscarriage was significantly increased in women at higher age (>33 years), lower body mass index (< or =20 kg/ m(2)) and lower serum progesterone concentrations (< or =12 ng/ml) prior to the onset of the miscarriage. Women with subsequent miscarriage also perceived higher levels of stress/demands (supported by higher concentrations of corticotrophin-releasing hormone) and revealed reduced concentrations of progesterone-induced blocking factor. These risk factors were even more pronounced in the subcohort of women (n = 335) recruited between gestation weeks 4 and 7. The identification of these risk factors and development of an interaction model of these factors, as introduced in this article, will help clinicians to recognize pregnant women who require extra monitoring and who might benefit from therapeutic interventions such as progestogen supplementation, especially during the first weeks of pregnancy, to prevent a miscarriage.

  6. "Supporting Early Career Women in the Geosciences through Online Peer-Mentoring: Lessons from the Earth Science Women's Network (ESWN)"

    Science.gov (United States)

    Holloway, T.; Hastings, M. G.; Barnes, R. T.; Fischer, E. V.; Wiedinmyer, C.; Rodriguez, C.; Adams, M. S.; Marin-Spiotta, E.

    2014-12-01

    The Earth Science Women's Network (ESWN) is an international peer-mentoring organization with over 2000 members, dedicated to career development and community for women across the geosciences. Since its formation in 2002, ESWN has supported the growth of a more diverse scientific community through a combination of online and in-person networking activities. Lessons learned related to online networking and community-building will be presented. ESWN serves upper-level undergraduates, graduate students, professionals in a range of environmental fields, scientists working in federal and state governments, post-doctoral researchers, and academic faculty and scientists. Membership includes women working in over 50 countries, although the majority of ESWN members work in the U.S. ESWN increases retention of women in the geosciences by enabling and supporting professional person-to-person connections. This approach has been shown to reduce feelings of isolation among our members and help build professional support systems critical to career success. In early 2013 ESWN transitioned online activities to an advanced social networking platform that supports discussion threads, group formation, and individual messaging. Prior to that, on-line activities operated through a traditional list-serve, hosted by the National Center for Atmospheric Research (NCAR). The new web center, http://eswnonline.org, serves as the primary forum for members to build connections, seek advice, and share resources. For example, members share job announcements, discuss issues of work-life balance, and organize events at professional conferences. ESWN provides a platform for problem-based mentoring, drawing from the wisdom of colleagues across a range of career stages.

  7. Management of early breast cancer in older women: from screening to treatment

    Directory of Open Access Journals (Sweden)

    Elomrani F

    2015-07-01

    Full Text Available Fadwa Elomrani,1 Maryem Zine,2 Mohamed Afif,3 Saad L'annaz,1 Imane Ouziane,1 Hind Mrabti,1 Hassan Errihani1 1Department of Medical Oncology, National Institute of Oncology, 2Department of Onco Hematology, Military Hospital Mohamed V, 3Department of Radiotherapy, National Institute of Oncology, Rabat, Morocco Background: Breast cancer is a common condition. It is a leading cause of death among women, and its incidence increases with age. Aging of the population and improvement of the quality of life of elders make it a major public health issue. We reviewed the literature to try to determine the management of breast cancer in older women.Methods: We conducted a narrative review by literature searches using key words “breast cancer”, “elderly and older”, and “women” in Pubmed, Scopus, and Google Scholar. The aim of this review is to summarize the management of early breast cancer in older women by discussing the controversies of screening in older women. Then, we try to define the optimal strategy for these women, either surgery alone or primary endocrine therapy. We also discuss the indications of lymph node dissection, and we evaluate the benefit of adjuvant radiotherapy, chemotherapy, and the anti HER2 treatment for these women.Results: More than 50% of patients with breast cancer are 65 years or older, and around 30% are more than 70 years old. Most randomized trials did not include older women. Hence, the treatment of breast cancer in older patients is based on the management provided to younger women. Regardless of age, the treatment must aim for the best efficiency. Advanced age in itself should not be a limitation to treatment. There are no standard guidelines set for elderly patients. Surgical treatment for older patients evolved to avoid mastectomy, and conservative mammary surgery was proposed, similar to that used in younger patients. The proportion of elderly patients receiving adjuvant radiotherapy is increasing. The role

  8. 妇女围绝经期综合征125例临床分析%Clinical analysis of 125 female patients suffering from perimenopausal syndrome

    Institute of Scientific and Technical Information of China (English)

    郭虹

    2011-01-01

    Objective To investigate the clinical manifestations and psychological status of women suffering fiom perimenopausal syndrome so as to provide some evidence for prevention and treatment. Methods From 2008 to 2010 125 women who diagnosed with perimenopausal syndrome in Gynecology Department of College Hospital of Xi' an Jiaotong University were investigated. Results For patients with perimenopausal syndrome, the incidence rates of symptoms of mind and neurosis, of genitourinary tract, of vasomotion, and of bone and arthrosis were 48.0% , 38.4% , 36.0%, 12.0% respectively. There were 62.4% patients who had clinical manifestations in 3 systems at same time. The incidence rates of crossness and impatience, anxiety and dread were 58.4% and 45.6% , respectively, which were much higher than those of other abnormal psychological manifestations (X2 = 104. 634, P < 0. 001 ). Conclusion Most women during perimenopausal period have mild complaints. Climacteric health care, suitable diet, keeping healthy psychology and symptomatic treatment are needed. Indication and contraindication should be clarified for severe cases, and a low dosage of estrogen can produce satisfactory therapeutic effect if used reasonably.%目的 了解围绝经期综合征妇女的临床表现和心理状况,为认真做好防治提供依据.方法 对2008年至2010年在西安交通大学医院妇科门诊就诊的125例临床诊断为围绝经期综合征的妇女进行调查.结果 在围绝经期综合征患者中,精神与神经症状、泌尿生殖道症状、血管舒缩症状、骨和关节症状的发生率分别为48.0%、38.4%、36.0%、12.0%,同时出现3个系统以上临床表现的患者占62.4%."固执、急躁"和"焦虑、恐惧"心理的发生率分别为58.4%和45.6%,明显高于其他异常心理表现(χ2=104.634,P<0.001).结论 围绝经期妇女多数患者症状较轻,只要注意围绝经期保健和合理饮食,保持健康心理,对症治疗即可;对重症

  9. Childhood physical abuse is associated with incident metabolic syndrome in mid-life women.

    Science.gov (United States)

    Midei, Aimee J; Matthews, Karen A; Chang, Yue-Fang; Bromberger, Joyce T

    2013-02-01

    Previous research has suggested that childhood emotional abuse, physical abuse, and sexual abuse are associated with an increased risk for ischemic heart disease. Our objective was to examine whether childhood abuse predicted incident metabolic syndrome, a precursor to heart disease, in midlife women. Participants were 342 (114 Black, 228 White) women from the Pittsburgh site of the Study of Women's Health Across the Nation (SWAN). SWAN included a baseline assessment of premenopausal or early perimenopausal women in midlife (mean age = 45.7), and women were evaluated for presence of the metabolic syndrome over 7 annual follow-up visits. Women were classified as having metabolic syndrome if they met 3 of the following criteria: waist circumference >88 cm, triglycerides ≥150 mg/dl, HDL Childhood Trauma Questionnaire is a standardized measure that retrospectively assesses 3 domains of abuse in childhood and adolescence: emotional, physical, and sexual abuse. Approximately 34% of the participants reported a history of abuse. Cox model survival analysis showed that physical abuse was associated with incident metabolic syndrome over the course of 7 years (HR = 2.12, p = .02), adjusted for ethnicity, age at baseline, and time-dependent menopausal status. Sexual abuse and emotional abuse were unrelated to the metabolic syndrome. This is the first study to show that a history of childhood abuse, specifically physical abuse, is related to the development of metabolic syndrome in midlife women.

  10. Sense of coherence and intentions to retire early among Finnish women and men

    Directory of Open Access Journals (Sweden)

    Lahelma Eero

    2010-01-01

    Full Text Available Abstract Background Previous studies have shown that age, physical and mental health status and working circumstances, along with different socio-economic and psychosocial factors affect the retirement process. However, the role of psychological resources, such as sense of coherence (SOC, on the retirement process is still poorly understood. This study investigated the associations between SOC and intentions to retire early and whether these associations were explained by socio-economic, psychosocial and work and health related factors. Methods The data were derived from the Finnish Health and Social Support (HeSSup Study. The information was gathered from postal surveys in 1998 (baseline and in 2003 (follow-up. The analyzed data consisted of 7409 women and 4866 men aged 30-54 at baseline. SOC and background factors including childhood circumstances, language, education, working circumstances, social support, health behaviour and somatic and mental health status were assessed at baseline. The intentions to retire early were assessed at follow-up using logistic regression analysis. Results SOC was associated with intentions to retire early among both genders. Socio-economic, psychosocial and work and health behaviour related factors did not influence the association between SOC and intentions to retire early among women and men reporting somatic or mental illness. Further, the association between SOC and intentions to retire early remained among (somatically and mentally healthy men. Among healthy women the association was weaker and statistically non-significant. Among unhealthy women, the odds ratios of SOC was 0.97 (CI 95% 0.96-0.98 and 0.97 among ill men (CI 95% 0.96-0.98, i.e., each additional SOC score reduced the risk of intentions by 3% among both genders. Conclusion Unhealthy employees with low SOC and low education were in the greatest risk to have reported intentions to retire early. SOC had an independent effect on intentions to

  11. Quality of life of Lithuanian women with early stage breast cancer

    OpenAIRE

    Bulotiene, Giedre; Veseliunas, Jonas; Ostapenko, Valerijus

    2007-01-01

    Background In the last decades, there have been no studies carried out in Lithuania on the quality of life of breast cancer patients. The aim of the present study was to evaluate changes in the quality of life of Lithuanian women with the early stage of breast cancer nine months after surgery and its dependence on surgical strategy, adjuvant chemotherapy and the social and demographic status of the patients. Methods Seventy-seven patients with early stage breast cancer filled in the FACT-An q...

  12. Pregnant women on thyroxine substitution are often dysregulated in early pregnancy.

    Science.gov (United States)

    Hallengren, Bengt; Lantz, Mikael; Andreasson, Bengt; Grennert, Lars

    2009-04-01

    Thyroid hormones are important for normal fetal development. Maternal hypothyroidism during early pregnancy is associated with impaired neuropsychological development of children and other adverse outcomes. The primary aim of this prospective study was to determine whether thyroxine-treated pregnant women with hypothyroidism are adequately thyroxine substituted in early pregnancy. A secondary aim was to determine if fetal loss differed between females with thyrotropin (TSH) values within and outside the reference range at their first TSH test, scheduled for 1-2 weeks after verification of pregnancy. This was a prospective open-labeled study. During the years 1997-2002, 119 consecutive pregnancies in 101 females with thyroid diseases were followed at the Department of Endocrinology, Malmö University Hospital. At the first visit, 63 patients, median age 30 years (range 17-45 years), were on thyroxine substitution therapy for hypothyroidism. In these patients 83% were in their first trimester at the time of the initial test. Of the 63 patients on thyroxine substitution for hypothyroidism 32 (51%; Group A) patients had serum TSH values within the reference range at their initial test and 31 (49%; Group B) had serum TSH values outside the reference range. Twelve (19%) had TSH values of 4.0 mIU=l. The fetal loss was 2 of 32 (6%) in Group A compared to 9 of 31 (29%) in Group B ( p pregnant women on thyroxine substitution, serum TSH values were outside the reference range when first tested, generally in the first trimester. Fetal loss was significantly greater in pregnant women with abnormal TSH values compared to those with normal TSH values. Thyroid function in pregnant women on thyroxine substitution should be monitored early in pregnancy and carefully followed during pregnancy. The thyroxine dose should be increased as needed early in pregnancy to avoid hypothyroidism.

  13. Early Maladaptive Schemas in Depressed Women and Its Relationship with Depression

    Directory of Open Access Journals (Sweden)

    Hacer Bolat KONUKÇU

    2013-07-01

    Full Text Available Objective: Objective: Schemas are deep enduring cognitive structures that are the source of dysfunctional cognitions, emotions and behaviors, activate after critical incidents in depression. A subset of schemas called Early Maladaptive Schemas (EMS which are hyphotised to arise from early traumatic and adverse life events are also claimed to be related with not only personality disorders but also mood disorders. In this study we aimed to investigate the relationship between early maladaptive schemas and depression and relationship between schema scores and depression severity in depressed women and compare it with non-depressed controls.Methods: 40 women attending to an outpatient psychiatry clinic and 30 healthy controls participated. All participants were assessed with SCID-1. Data were obtained by using a Sociodemographic Questionnaires, Young Schema Questionnaire-Short Form 3 (YSQ and Beck Depression Inventory (BDI.Results: All except one (enmeshment/undeveloped self maladaptive schema scores of depressed women were higher than controls. BDI was correlated to some schema and schema domain scores in both depressed and control groups but the correlations were stronger in control group. Mean emotional deprivation, negativism, abandonment and instability, failure EMS scores showed the highest difference between two groups. The schema domains most related to depression symptom severity were disconnection and rejection, impaired autonomy and performance.Conclusions: Almost all early maladaptive schemas are related to depression, and some schemas are related to depression symptom severity but these correlations are weaker in control group. This may mean that EMS are stable and mood independent structures. Although other schemas are related to depression, mostly related EMS in women might be emotional deprivation schema. These schemas may also overlap with Beck’s unlovability core belief or sociotropy dimension

  14. Purposiveness and leisure-time physical activity in women in early midlife.

    Science.gov (United States)

    Holahan, Carole K; Holahan, Charles J; Velasquez, Katherine E; Jung, Sooin; North, Rebecca J; Pahl, Sandra A

    2011-11-01

    Physical activity in early midlife has important implications for women's health. The present cross-sectional study investigated the relation of purposiveness to leisure-time physical activity, as mediated by health investment, in a sample of women in early midlife. Participants were 211 women between the ages of 35 and 45 years (mean 40.55 years, SD = 3.11) who responded to the second wave of the study of Midlife Development in the United States. Participants were originally selected by means of a nationally representative random-digit-dialing procedure. A structural equation analysis of data with latent variables was conducted with MPLUS. Purposiveness was indexed by measures of purpose in life, personal growth, and future planning. Health investment was indexed by thought and effort committed to health and the extent to which individuals worked hard to stay healthy. Leisure-time physical activity was indexed by both moderate and vigorous leisure-time activity. Results, controlling for sociodemographic factors, showed that purposiveness was associated with more physical activity and that the relation between purposiveness and leisure-time physical activity was fully mediated by health investment. These results suggest that women with a sense of purpose may be better able to achieve acceptable levels of physical activity.

  15. Clinical Efficacy Analysis on Treatment of Peri-menopausal Syndrome with Electroacpuncture

    Institute of Scientific and Technical Information of China (English)

    何金森; 廖建钦; 安晓英; 许建敏; 王静

    2006-01-01

    Objective and Methods: Thirty-three patients with peri-menopausal syndrome were treated by electroacupuncture of points Guanyuan (CV 4) and Sanyinjiao (SP 6) according to the principle of regulating and tonifying the Thoroughfare and Conception vessels, and the curative effects were analyzed.Results and Conclusion: The results showed that there was a significant difference in the clinical symptoms of the patients with peri-menopausal syndrome between pre- and post-electroacupuncture of points Guanyuan (CV 4) and Sanyinjiao (CV 6) and the clinical effective rate reached 93.9%. The measurement of sexual hormones showed E2, FSH and LH levels were better after treatment than before treatment in the patients with peri-menopausal syndrome. The analyses indicated that electroacupuncture of points Guanyuan (CV 4) and Sanyinjiao (CV 6) could relieve the clinical symptoms in the patients with peri-menopausal syndrome and improve the patient's life quality.%目的与方法:电针关元和三阴交穴,以调补冲任为施治原则,对33例围绝经期综合征患者进行临床治疗效应分折.结果与结论:发现电针关元、三阴交穴对改善围绝经期患者临床症状有明显统计学差异,临床有效率达93.9%.性激素检测也发现治疗后围绝经期患者E2、FSH、LH水平较治疗前有所改善.分析表明电针关元和三阴交穴可以缓解围绝经期综合征患者临床症状,提高患者的生活质量.

  16. Early Gestational Weight Gain Rate and Adverse Pregnancy Outcomes in Korean Women.

    Directory of Open Access Journals (Sweden)

    Eun-Hee Cho

    Full Text Available During pregnancy, many women gain excessive weight, which is related to adverse maternal and neonatal outcomes. In this study, we evaluated whether rate of gestational weight gain (RGWG in early, mid, and late pregnancy is strongly associated with adverse pregnancy outcomes. A retrospective chart review of 2,789 pregnant Korean women was performed. Weights were recorded at the first clinic visit, during the screening test for fetal anomaly, and during the 50g oral glucose challenge test and delivery, to represent early, mid, and late pregnancy, respectively. A multivariate logistic regression analysis was performed to examine the relationship between RGWG and adverse pregnancy outcomes. At early pregnancy, the RGWG was significantly associated with high risk of developing gestational diabetes mellitus (GDM, pregnancy-induced hypertension (PIH, large for gestational age (LGA infants, macrosomia, and primary cesarean section (P-CS. The RGWG of mid pregnancy was not significantly associated with any adverse pregnancy outcomes. The RGWG at late pregnancy was significantly associated with a lower risk of developing GDM, preterm birth and P-CS, but with a higher risk of developing LGA infants and macrosomia. When the subjects were divided into three groups (Underweight, Normal, and Obese, based on pre-pregnancy body mass index (BMI, the relationship between early RGWG and adverse pregnancy outcomes was significantly different across the three BMI groups. At early pregnancy, RGWG was not significantly associated to adverse pregnancy outcomes for subjects in the Underweight group. In the Normal group, however, early RGWG was significantly associated with GDM, PIH, LGA infants, macrosomia, P-CS, and small for gestational weight (SGA infants, whereas early RGWG was significantly associated with only a high risk of PIH in the Obese group. The results of our study suggest that early RGWG is significantly associated with various adverse pregnancy outcomes

  17. Pregnancy planning and lifestyle prior to conception and during early pregnancy among Danish women.

    Science.gov (United States)

    Backhausen, Mette G; Ekstrand, Maria; Tydén, Tanja; Magnussen, Britta Kjeldberg; Shawe, Jill; Stern, Jenny; Hegaard, Hanne K

    2014-02-01

    OBJECTIVE To investigate the extent to which Danish women attending antenatal care plan their pregnancies and to determine the association between pregnancy planning and the intake of folic acid, alcohol consumption and smoking habits prior to conception and before the 16th week of gestation. METHODS A cross-sectional survey of 258 women. intake of folic acid, alcohol consumption and smoking. Pregnancy planning was assessed by the London Measure of Unplanned Pregnancy (LMUP) and the five graded Swedish Pregnancy Planning Scale. RESULTS Most (77%) of the participants reported that their pregnancies were very or fairly well planned. Higher median LMUP scores were observed in women taking folic acid (p planning and 98% of those with a low degree of planning had not taken folic acid prior to pregnancy. Binge drinking during early pregnancy was reported by 20% of women with a high degree of planned pregnancy and 31% of those with a low degree (p = 0.1). CONCLUSION Pregnancy planning was associated with a healthier lifestyle but still many women could improve their lifestyle in connection to pregnancy. Their level of alcohol consumption is higher than that recommended for best pregnancy outcome.

  18. Body image in recently diagnosed young women with early breast cancer.

    Science.gov (United States)

    Rosenberg, Shoshana M; Tamimi, Rulla M; Gelber, Shari; Ruddy, Kathryn J; Kereakoglow, Sandra; Borges, Virginia F; Come, Steven E; Schapira, Lidia; Winer, Eric P; Partridge, Ann H

    2013-08-01

    To assess body image concerns among young women following a breast cancer diagnosis. A total of 419 women with recently diagnosed stage 0-III breast cancer were surveyed following enrollment as part of a prospective cohort study of women age 40 or younger at diagnosis. Body image was assessed using three items from the psycho-social scale of the Cancer Rehabilitation Evaluation System (CARES). CARES scores range from 0 to 4, with higher scores indicative of greater image concerns. Mean CARES scores were calculated and compared between treatment groups using t-tests and analysis of variance. Multiple linear regression models were fit to evaluate the relationship between physical and psychological factors and body image. Mean time from diagnosis to completion of the baseline survey was 5.2 months. The mean CARES score for all women was 1.28. Mean CARES scores in the mastectomy-only group (1.87) and in the mastectomy with reconstruction group (1.52) were significantly higher (p body image concerns. Radiation (p = 0.01), anxiety (p = 0.0001), depression (p body image concerns in the multi-variable analysis. This analysis highlights the impact of treatment, along with physical and psychological factors, on body image early in the survivorship period. Our findings provide targets for potential future intervention and may aid young women in the surgical decision-making process. Copyright © 2012 John Wiley & Sons, Ltd.

  19. Early postpartum maternal morbidity among rural women of Rajasthan, India: a community-based study.

    Science.gov (United States)

    Iyengar, Kirti

    2012-06-01

    The first postpartum week is a high-risk period for mothers and newborns. Very few community-based studies have been conducted on patterns of maternal morbidity in resource-poor countries in that first week. An intervention on postpartum care for women within the first week after delivery was initiated in a rural area of Rajasthan, India. The intervention included a rigorous system of receiving reports of all deliveries in a defined population and providing home-level postpartum care to all women, irrespective of the place of delivery. Trained nurse-midwives used a structured checklist for detecting and managing maternal and neonatal conditions during postpartum-care visits. A total of 4,975 women, representing 87.1% of all expected deliveries in a population of 58,000, were examined in their first postpartum week during January 2007-December 2010. Haemoglobin was tested for 77.1% of women (n=3,836) who had a postnatal visit. The most common morbidity was postpartum anaemia--7.4% of women suffered from severe anaemia and 46% from moderate anaemia. Other common morbidities were fever (4%), breast conditions (4.9%), and perineal conditions (4.5%). Life-threatening postpartum morbidities were detected in 7.6% of women--9.7% among those who had deliveries at home and 6.6% among those who had institutional deliveries. None had a fistula. Severe anaemia had a strong correlation with perinatal death [pcaste or tribe [p<0.000, AOR=2.47 (95% CI 1.83-3.33)], and parity of three or more [p<0.000, AOR=1.52 (95% CI 1.18-1.97)]. The correlation with antenatal care was not significant. Perineal conditions were more frequent among women who had institutional deliveries while breast conditions were more common among those who had a perinatal death. This study adds valuable knowledge on postpartum morbidity affecting women in the first few days after delivery in a low-resource setting. Health programmes should invest to ensure that all women receive early postpartum visits after

  20. Negative body experience in women with early childhood trauma: associations with trauma severity and dissociation.

    Science.gov (United States)

    Scheffers, Mia; Hoek, Maike; Bosscher, Ruud J; van Duijn, Marijtje A J; Schoevers, Robert A; van Busschbach, Jooske T

    2017-01-01

    Background: A crucial but often overlooked impact of early life exposure to trauma is its far-reaching effect on a person's relationship with their body. Several domains of body experience may be negatively influenced or damaged as a result of early childhood trauma. Objective: The aim of this study was to investigate disturbances in three domains of body experience: body attitude, body satisfaction, and body awareness. Furthermore, associations between domains of body experience and severity of trauma symptoms as well as frequency of dissociation were evaluated. Method: Body attitude was measured with the Dresden Body Image Questionnaire, body satisfaction with the Body Cathexis Scale, and body awareness with the Somatic Awareness Questionnaire in 50 female patients with complex trauma and compared with scores in a non-clinical female sample (n = 216). Patients in the clinical sample also filled out the Davidson Trauma Scale and the Dissociation Experience Scale. Results: In all measured domains, body experience was severely affected in patients with early childhood trauma. Compared with scores in the non-clinical group, effect sizes in Cohen's d were 2.7 for body attitude, 1.7 for body satisfaction, and 0.8 for body awareness. Associations between domains of body experience and severity of trauma symptoms were low, as were the associations with frequency of dissociative symptoms. Conclusions: Early childhood trauma in women is associated with impairments in self-reported body experience that warrant careful assessment in the treatment of women with psychiatric disorders.

  1. A systematic review of barriers to early presentation and diagnosis with breast cancer among black women

    Science.gov (United States)

    Jones, Claire EL; Maben, Jill; Jack, Ruth H; Davies, Elizabeth A; Forbes, Lindsay JL; Lucas, Grace; Ream, Emma

    2014-01-01

    Objective To explore barriers to early presentation and diagnosis with breast cancer among black women. Design Systematic review. Methods We searched multiple bibliographic databases (January 1991–February 2013) for primary research, published in English, conducted in developed countries and investigating barriers to early presentation and diagnosis with symptomatic breast cancer among black women (≥18 years). Studies were excluded if they did not report separate findings by ethnic group or gender, only reported differences in time to presentation/diagnosis, or reported on interventions and barriers to cancer screening. We followed Cochrane and PRISMA guidance to identify relevant research. Findings were integrated through thematic synthesis. Designs of quantitative studies made meta-analysis impossible. Results We identified 18 studies (6183 participants). Delay was multifactorial, individual and complex. Factors contributing to delay included: poor symptom and risk factor knowledge; fear of detecting breast abnormality; fear of cancer treatments; fear of partner abandonment; embarrassment disclosing symptoms to healthcare professionals; taboo and stigmatism. Presentation appears quicker following disclosure. Influence of fatalism and religiosity on delay is unclear from evidence in these studies. We compared older studies (≥10 years) with newer ones (<10 years) to determine changes over time. In older studies, delaying factors included: inaccessibility of healthcare services; competing priorities and concerns about partner abandonment. Partner abandonment was studied in older studies but not in newer ones. Comparisons of healthy women and cancer populations revealed differences between how people perceive they would behave, and actually behave, on finding breast abnormality. Conclusions Strategies to improve early presentation and diagnosis with breast cancer among black women need to address symptom recognition and interpretation of risk, as well as

  2. Primary Study on Medical Abortion in Early Pregnant Women with Myoma of Uterus

    Institute of Scientific and Technical Information of China (English)

    Chen CHEN; Xiao-ai LIU; Yu-cui JIN

    2002-01-01

    Objective To study the effectiveness and acceptability of the medical termination of early pregnancy accompanied with myoma Methods A total of 92 early pregnant women with myoma were admitted. Every woman was administrated mifepristone 150 mg in the first two days and Misoprostol 1 000 μg on d 3.Results The complete abortion rate was 89. 13%. The average bleeding duration was 11. 89± 6. 87 d. The expulsion time of gestational cyst was affected by the size of myoma. The bleeding duration and the expulsion time of gestational cyst were affected by the size of myoma and gestational cyst. The location and the number of myoma had no effect on the bleeding duration and the recovery of menses.Conclusion Mifepristone and Misoprostol could be safely and effectively used in the termination of early pregnancy with myoma.

  3. Early Women Sociologist and the American Sociological Society: the Patterns of Exclusion and Participation

    Directory of Open Access Journals (Sweden)

    Mary Jo Deegan

    2012-12-01

    Full Text Available American sociology owes a significant debt to early women professionals. Although discriminatedagainst as full colleagues, they nonetheless contributed to sociological thoughtand participated in professional activities. Evidence of both the barriers and opportunitiesaffecting these early female leaders is found in the records of the American SociologicalSociety during its founding years; i.e., from 1906-1931. Analysis of this information, aswell as personal documents of sociologists working during this period, reveals that womendid participate within a restricted range of “expertise”, often associated with traditionalsex roles. Jane Addams was a significant figure in these early years and was a leader withinthe separate, more institutionally limited female sociologist’s network.

  4. Rehabilitation effects of walking and baduanjin to the perimenopausal syndrome with depression%步行与八段锦对围绝经期综合征伴抑郁症状的康复效果

    Institute of Scientific and Technical Information of China (English)

    马素慧; 窦娜; 陈长香; 赵雅宁

    2011-01-01

    Objective: To research and compare the rehabilitation effects of walking and baduanjin on perimenopausal syndrome with depression, and find non-drug therapy to treat perimenopausal syndrome effectively.Method: Assessed at Kupperman score≥16 (means heavier than moderate perimenopausal syndrome) and center for epidemiologic studies depression scale (CES-D)≥20(means depression), 145 perimenopausal women from Xishan Road Community in Tangshan city, 45-55 years' old, were randomly divided into 3 groups based on their serial number. 50 persons in control group(with no exercise), 46 in walking group and 49 in haduanjin group.Evaluations were taken with Kupperman score and CES-D after 3-month training.Result: Compared to control group, the differences of Kupperman scores and CES-D scores in baduanjin group and walking group all were significant(P<0.01). Compared with walking group, the CES-D score of haduanjin group improved(P<0.01). According to the single items scores of Kupperman, both in walking and haduanjin group hectic fever, sweating, insomnia, fuss,depress, fatigue, muscle and joint pain released(P<0.05),and the effect of baduanjin on insomnia, fuss, depress, and palpitation was better than that of walking.Conclusion:Walking and haduanjin could alleviate perimenopausal syndromes effectively, and baduanjin could suit adapts to peri-menopausal women's health more.%目的:观察并比较步行与八段锦等运动训练治疗围绝经期综合征伴抑郁的康复效果,寻找非药物治疗围绝经期综合征的有效途径.方法:用Kupperma评分法和流行病学调查--抑郁量表(CES-D)对唐山市西山道社区围绝经期妇女进行筛查,选取Kupperman评分≥16分(即围绝经期综合征中度以上)以及CES-D评分≥20分(即存在抑郁症状)患者145例,年龄45-55岁之间;按数字排序随机分对照组50例,步行组46例和八段锦组49例,训练3个月后对三组用改良Kupper-ma量表和CES-D量表进行评价.结果:训

  5. Early-life conditions and age at first pregnancy in British women.

    Science.gov (United States)

    Nettle, Daniel; Coall, David A; Dickins, Thomas E

    2011-06-01

    There is growing evidence that the reproductive schedules of female mammals can be affected by conditions experienced during early development, with low parental investment leading to accelerated life-history strategies in the offspring. In humans, the relationships between early-life conditions and timing of puberty are well studied, but much less attention has been paid to reproductive behaviour. Here, we investigate associations between early-life conditions and age at first pregnancy (AFP) in a large, longitudinally studied cohort of British women (n = 4553). Low birthweight for gestational age, short duration of breastfeeding, separation from mother in childhood, frequent family residential moves and lack of paternal involvement are all independently associated with earlier first pregnancy. Apart from that of birthweight, the effects are robust to adjustment for family socioeconomic position (SEP) and the cohort member's mother's age at her birth. The association between childhood SEP and AFP is partially mediated by early-life conditions, and the association between early-life conditions and AFP is partially mediated by emotional and behavioural problems in childhood. The overall relationship between early-life adversities and AFP appears to be approximately additive.

  6. Understanding Perceived Benefit of Early Cancer Detection: Community-Partnered Research with African American Women in South Los Angeles.

    Science.gov (United States)

    Bazargan, Mohsen; Lucas-Wright, Anna; Jones, Loretta; Vargas, Roberto; Vadgama, Jaydutt V; Evers-Manly, Shirley; Maxwell, Annette E

    2015-09-01

    African American women have lower 5-year cancer survival rates than non-Latino White women. Differences in perceived benefits of early cancer detection among racial/ethnic groups may affect cancer-screening behaviors. This study assessed correlates of perceived benefits of early breast, cervical and colorectal cancer detection among 513 African American women. Using a community-partnered participatory research approach, we conducted a survey on cancer screening, risk behaviors, and related knowledge and attitudes among African American parishioners at 11 churches in South Los Angeles, a neighborhood that experiences one of the highest cancer mortality rates in California. African American women who participated in this study were more likely to believe that chances for survival are very good or good after early detection of breast cancer (74%) than after early detection of colorectal (51%) and cervical cancer (52%). Multivariate analyses show that perceived benefit of early cancer detection is associated with higher cancer knowledge and having discussed one's cancer risk with a doctor. Given that 5-year survival rates for early stage breast, cervical, and colorectal cancer range from 84% to 93%, our data suggest that a substantial proportion of African American women in South Los Angeles are not aware of the benefits of early detection, particularly of colorectal and cervical cancers. Programs that increase cancer knowledge and encourage a discussion of individual's cancer risk with a doctor may be able to increase perceived benefit of early detection, a construct that has been shown to be associated with cancer screening in some studies.

  7. 增强预防意识,积极应对围绝经期阴道流血%Enhancing the awareness of prevention and response for perimenopausal abnormal vaginal bleeding

    Institute of Scientific and Technical Information of China (English)

    林守清

    2012-01-01

    The prevalence of abnormal uterine bleeding(AUB) is high. All the following things should be taken into consideration when the AUB occurred in women who are in the perimenopause, such as the ovulatory disorders induced by o-vary aging, the relative or absolutely high level of estrogen, and other strengthened or increased risk factors of AUB during the perimenopausal stage. Therefore, it is important to prevent AUB on the respects of overall health and quality of life for promoting women health care.%发生于围绝经期的异常子宫出血(abnormal uterine bleeding,AUB)须考虑卵巢功能衰退所致排卵障碍,相对或绝对高雌激素的影响;也应考虑发生AUB的其他危险因素增强、增多的影响.从整体健康及生活质量的角度预防AUB是妇女保健的一个重要内容.

  8. An Inverse Relationship Between Weight and Free Thyroxine During Early Gestation Among Women Treated for Hypothyroidism.

    Science.gov (United States)

    Haddow, James E; Neveux, Louis M; Palomaki, Glenn E; Lambert-Messerlian, Geralyn; Malone, Fergal D; D'Alton, Mary E

    2015-08-01

    Following treatment sufficient to normalize thyrotropin (TSH), nonpregnant hypothyroid adults display higher free thyroxine (FT(4)) concentrations than a reference population. Our aim is to determine whether FT(4) concentrations are higher during pregnancy among women treated for hypothyroidism and whether their weight is associated with FT(4) levels. Weight/FT(4) relationships have not previously been reported in treated hypothyroid adults (either pregnant or nonpregnant). Thyroid-related measurements were available from over 10,000 women at two early pregnancy time periods from the FaSTER (First and Second Trimester Evaluation of Risk for Fetal aneuploidy) trial (1999-2002). All women were receiving routine prenatal care. Present analyses were restricted to 9267 reference women and 306 treated, hypothyroid women with TSH between the 2nd and 98th reference percentiles. We compared FT(4) values between those groups at 11-14 and 15-18 weeks' gestation, using linear regression to estimate FT(4)/maternal weight relationships, after accounting for treatment and other potential covariates. In comparison to reference women, median FT(4) values and percent of FT(4) values ≥95th reference percentile were significantly higher in treated women at both 11-14 and 15-18 weeks' gestation (pwomen, median FT(4) decreased monotonically with increasing weight, regardless of anti-thyroperoxidase antibody status. Maternal age, maternal weight, and treatment status were important predictors of FT(4) levels (pwomen, independent of other factors. Maternal age and weight reduced FT(4) levels by 0.0694 pmol/L/y and 0.0208 pmol/L/kg, respectively. FT(4) concentrations are higher among treated hypothyroid pregnant women than among reference women, and higher maternal weight is associated with lower FT(4) levels, regardless of treatment status. This inverse relationship is not associated with higher TSH levels. While no immediate clinical implications are attached to the current

  9. Early predictors of daily smoking in young women : The National Heart, Lung, and Blood Institute Growth and Health Study

    NARCIS (Netherlands)

    Voorhees, CC; Schreiber, GB; Schumann, BC; Biro, F; Crawford, PB

    2002-01-01

    Background. Smoking is highly prevalent in young women and little is known about early multilevel independent risk or protective factors that are predictive of daily smoking in young women. Methods. Multiple logistic regression was conducted on data from NGHS, a 10-year cohort study of Black (1,213)

  10. Endothelial function in women of the Kronos Early Estrogen Prevention Study.

    Science.gov (United States)

    Kling, J M; Lahr, B A; Bailey, K R; Harman, S M; Miller, V M; Mulvagh, S L

    2015-04-01

    Endothelial dysfunction occurs early in the atherosclerotic disease process, often preceding clinical symptoms. Use of menopausal hormone treatment (MHT) to reduce cardiovascular risk is controversial. This study evaluated effects of 4 years of MHT on endothelial function in healthy, recently menopausal women. Endothelial function was determined by pulse volume digital tonometry providing a reactive hyperemia index (RHI) in a subset of women enrolled in the Kronos Early Estrogen Prevention Study. RHI was measured before and annually after randomization to daily oral conjugated equine estrogen (oCEE, 0.45 mg), weekly transdermal 17β-estradiol (tE2, 50 μg) each with intermittent progesterone (200 mg daily 12 days of the month) or placebo pills and patch. At baseline, RHI averaged 2.39 ± 0.69 (mean ± standard deviation; n = 83), and over follow-up did not differ significantly among groups: oCEE, 2.26 ± 0.48 (n = 26); tE2, 2.26 ± 0.45 (n = 24); and placebo, 2.37 ± 0.37 (n = 33). Changes in RHI did not correlate with changes in traditional cardiovascular risk factors, but may inversely correlate with carotid intima medial thickness (Spearman correlation coefficient ρ = -0.268, p = 0.012). In this 4-year prospective assessment of recently menopausal women, MHT did not significantly alter RHI when compared to placebo.

  11. Providers' constructions of pregnant and early parenting women who use substances.

    Science.gov (United States)

    Benoit, Cecilia; Stengel, Camille; Marcellus, Lenora; Hallgrimsdottir, Helga; Anderson, John; MacKinnon, Karen; Phillips, Rachel; Zazueta, Pilar; Charbonneau, Sinead

    2014-02-01

    The research literature indicates that problematic substance use as a form of health behaviour is poorly understood, being sometimes viewed as deviance, at other times as a disease, and most often as a combination of these states. The use of substances by women who are pregnant or new parents is often conceptualised within an individualised framework. Yet drinking alcohol and using other drugs during pregnancy and early parenthood cuts across social divisions and is shaped by socio-structural contexts including health care. There is a growing body of literature that critically examines public health interventions that are aimed at implementing harm reduction and health promotion techniques in service delivery to help pregnant and early parenting women who are identified as problem substance users. We examine qualitative data from representatives of a recent harm reduction intervention, focusing, in particular, on providers' individual conceptualisations of the problematic behaviour. Our results show that most study participants regard any substance use during pregnancy, birth and the postpartum period as fundamentally unacceptable. This framing of problematic substance use is accomplished via gendered responsibilisation of women as foetal incubators and primary caregivers of infants. We discuss our results in light of the current literature and suggest policy implications.

  12. Effects of Online Self-Regulation Activities on Physical Activity Among Pregnant and Early Postpartum Women.

    Science.gov (United States)

    Kim, Hye Kyung; Niederdeppe, Jeff; Graham, Meredith; Olson, Christine; Gay, Geri

    2015-01-01

    Physical and psychological changes that occur during pregnancy present a unique challenge for women's physical activity. Using a theory-based prospective design, this study examines the effects of pregnant women's (a) physical activity cognitions (self-efficacy, outcome expectancy, and safety beliefs) and (b) online self-regulation activities (goal-setting and self-monitoring) on subsequent changes in their physical activity intentions and behavior during pregnancy and immediately postpartum. The authors used data from three panel surveys administered to pregnant women enrolled in a web-based intervention to promote healthy pregnancy and postpartum weight, as well as log data on their use of self-regulatory features on the intervention website. Perceived self-efficacy and perceived safety of physical activity in pregnancy enhanced subsequent intentions to be physically active. Repeated goal-setting and monitoring of those goals helped to maintain positive intentions during pregnancy, but only repeated self-monitoring transferred positive intentions into actual behavior. Theoretically, this study offers a better understanding of the roles of self-regulation activities in the processes of goal-striving. The authors also discuss practical implications for encouraging physical activity among pregnant and early postpartum women.

  13. Relationship between fasting glucose, vitamin D and PTH in early postmenopausal women

    DEFF Research Database (Denmark)

    við Streym, Susanna; Rejnmark, Lars; Vestergaard, Peter;

    2010-01-01

      Abstract Relationship between fasting glucose, vitamin D and PTH in early postmenopausal women Súsanna við Streym Thomsen (1), Lars Rejnmark (1), Peter Vestergaard (1), Christine Brot (2), Pia Eiken (3), Pernille Hermann (4) Leif Mosekilde (1). (1) Department of Medicine and Endocrinology C...... postmenopausal Caucasian women (n=2016) aged 45 to 58 years old. Measurements: Fasting blood glucose was measured after an overnight fast by standard laboratory methods. Serum levels of 25OHD were measured by a competitive assay using rachitic rat binding protein. The fat and lean mass was measured by DXA...... between fasting blood glucose and 25OHD and all studied indices. In a multivariate linear regression analyzing fasting blood glucose was significantly associated with BMI (b=0.038 ±0.007 (SE), 2p

  14. Total laparoscopic hysterectomy for early stage endometrial cancer in obese and morbidly obese women.

    Science.gov (United States)

    Farthing, A; Chatterjee, J; Joglekar-Pai, P; Dorney, E; Ghaem-Maghami, S

    2012-08-01

    This is a retrospective observational study, where we have evaluated the role of total laparoscopic hysterectomy (TLH) in obese and morbidly obese patients with early stage endometrial cancer. Our study illustrates that low conversion rates are achievable when appropriately trained surgeons undertake this procedure. All the women with high BMI were operated on laparoscopically in preference to laparotomy, unless there was an obvious contraindication such as a very large uterus or disseminated disease. We have also shown low conversation and complication rates for our patients, in particular a low rate of wound infection. This is in contrast to the high rate of wound infection and prolonged hospital stay reported for obese patients in the literature. Our study shows that TLH for endometrial cancer in obese women is feasible, safe and is likely to be cost-effective and adds to the weight of evidence for its use in this condition.

  15. Association of Kidney Function and Early Kidney Injury With Incident Hypertension in HIV-Infected Women.

    Science.gov (United States)

    Ascher, Simon B; Scherzer, Rebecca; Peralta, Carmen A; Tien, Phyllis C; Grunfeld, Carl; Estrella, Michelle M; Abraham, Alison; Gustafson, Deborah R; Nowicki, Marek; Sharma, Anjali; Cohen, Mardge H; Butch, Anthony W; Young, Mary A; Bennett, Michael R; Shlipak, Michael G

    2017-02-01

    Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injury: α-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid-binding protein, N-acetyl-β-d-glucosaminidase, and α1-acid-glycoprotein. We used multivariable Poisson regression to evaluate associations of kidney biomarkers with incident hypertension, defined as 2 consecutive visits of antihypertensive medication use. During a median follow-up of 9.6 years, 288 HIV-infected women (35%) developed hypertension. Among the HIV-infected women, higher urine albumin-to-creatinine ratio was independently associated with incident hypertension (relative risk =1.13 per urine albumin-to-creatinine ratio doubling, 95% confidence interval, 1.07-1.20), as was lower estimated glomerular filtration rate (relative risk =1.10 per 10 mL/min/1.73 m(2) lower estimated glomerular filtration rate; 95% confidence interval, 1.04-1.17). No tubular injury and dysfunction biomarkers were independently associated with incident hypertension in HIV-infected women. In contrast, among the HIV-uninfected women, urine albumin-to-creatinine ratio was not associated with incident hypertension, whereas higher urine interleukin-18, α1-acid-glycoprotein, and N-acetyl-β-d-glucosaminidase levels were significantly associated with incident hypertension. These findings suggest that early glomerular injury and kidney dysfunction may be involved in the pathogenesis of hypertension in

  16. Strategies for the prevention and treatment of osteoporosis during early postmenopause.

    Science.gov (United States)

    Delaney, Miriam F

    2006-02-01

    During the perimenopause, both the quantity and quality of bone decline rapidly, resulting in a dramatic increase in the risk of fracture in postmenopausal women. Although many factors are known to be associated with osteoporotic fractures, measures to identify and treat women at risk are underused in clinical practice. Consequently, osteoporosis is frequently not detected until a fracture occurs. Identification of postmenopausal women at high risk of fracture therefore is a priority and is especially important for women in early postmenopause who can benefit from early intervention to maintain or to increase bone mass and, thus, reduce the risk of fracture. Most authorities recommend risk-factor assessment for all postmenopausal women, followed by bone mineral density measurements for women at highest risk (ie, all women aged > or =65 years, postmenopausal women aged or =1 additional risk factors for osteoporosis, and postmenopausal women with fragility fractures). All postmenopausal women can benefit from nonpharmacologic interventions to reduce the risk of fracture, including a balanced diet with adequate intake of calcium and vitamin D, regular exercise, measures to prevent falls or to minimize their impact, smoking cessation, and moderation of alcohol intake. Several pharmacologic agents, including the bisphosphonates (eg, alendronate, risedronate, and ibandronate) and the selective estrogen receptor modulator, raloxifene, have been shown to increase bone mass, to reduce fracture risk, and to have acceptable side-effect profiles. Women who have discontinued hormone therapy are in particular need of monitoring for fracture risk, in light of the accelerated bone loss and increased risk of fracture that occurs after withdrawal of estrogen treatment.

  17. Potential Benefits of Berberine in the Management of Perimenopausal Syndrome

    Directory of Open Access Journals (Sweden)

    Cristiana Caliceti

    2015-01-01

    Full Text Available Cardiovascular diseases are one of the leading causes of morbidity and mortality in women after menopause and 56% of all causes of death in Western European countries. Nowadays, with increasing life span, women spend approximately one-third of their life-time in postmenopausal state; therefore, the development of new strategies to improve the prevention and treatment of menopause-associated pathologies is important topic in clinical practice. The studies to assess the safety of hormone replacement therapy in women with estrogen deficiency have not been conclusive due to the relative contraindications; therefore, hormone replacement therapy is prescribed only in selected cases and for a limited time. For this reason, today women are encouraged to use naturally available compounds to prevent or to attenuate menopausal symptoms and correlated pathologies, with fewer side effects. Among these compounds, berberine, an isoquinoline alkaloid derived from plants of the generis Berberis, has been recognized as being capable of decreasing oxidative stress, LDL, triglycerides, and insulin resistance and of improving the mood. This review describes the cellular and clinical effects associated with the use of berberine, which suggest that this molecule could be an effective natural supplement to ensure a smooth peri- and postmenopausal transition.

  18. Effect of hormone replacement therapy on bone quality in early postmenopausal women

    DEFF Research Database (Denmark)

    Paschalis, E P; Boskey, A L; Kassem, M

    2003-01-01

    proteins. In the present study, the technique of Fourier transform infrared microscopic imaging (FTIRI) was used to investigate the effect of estrogen on bone quality (arbitrarily defined as mineral/matrix ratio, mineral crystallinity/maturity, and relative ratio of collagen cross-links [pyridinoline/ de......H-DHLNL]) at the ultrastructural level, in mineralized, thin tissue sections from double (before and after administration of HRT regimen; cyclic estrogen and progestogen [norethisterone acetate]) iliac crest biopsy specimens from 10 healthy, early postmenopausal women who were not on any medication with known influence on calcium...

  19. Visible Women: Female Sodomy in the Late Medieval and Early Modern Southern Netherlands (1400-1550

    Directory of Open Access Journals (Sweden)

    Jonas Roelens

    2015-09-01

    Full Text Available Compared to the number of prosecutions for male sodomy, few cases of same-sex acts between women are known in early modern Europe. In the Southern Netherlands however, no less than 25 women were charged with this crime between c. 1400 and 1550, which means that nearly one out of ten accused sodomites in the region was a woman. Moreover, female sodomites were punished in the same way as their male counterparts. This article argues that the exceptional repression of female same-sex acts was the result of the relatively high level of liberty and visibility women enjoyed in the Southern Netherlands, compared to other regions. The more visible women were in society, the more women attracted to people of their own sex were at risk of being discovered and penalised. Zichtbare vrouwen. Vrouwelijke sodomie in de laatmiddeleeuwse en vroegmoderne Zuidelijke Nederlanden (1400-1550In vergelijking met het aantal mannelijke sodomieprocessen dat in vroegmodern Europa gevoerd werd, zijn er amper zaken bekend waarin vrouwen betrokken waren. In de Zuidelijke Nederlanden daarentegen werden niet minder dan 25 vrouwelijke sodomieten vervolgd tussen ca. 1400 en 1550. Dit betekent dat bijna één op de tien beschuldigde sodomieten in de Zuidelijke Nederlanden vrouwen waren. Bovendienwerden vrouwelijke sodomieten op dezelfde manier bestraft als hun mannelijke tegenhangers. Dit artikel stelt dat de grote mate van vrijheid en zichtbaarheid die vrouwen in de Zuidelijke Nederlanden genoten de oorzaak is van de uitzonderlijk hoge vervolgingsgraad van vrouwelijke sodomie in de regio. Hoe zichtbaarder vrouwen waren in de maatschappij, hoe groter het risico voor vrouwen die zich aangetrokken voelden tot andere vrouwen om ontdekt en bestraft te worden.

  20. Visible Women: Female Sodomy in the Late Medieval and Early Modern Southern Netherlands (1400-1550

    Directory of Open Access Journals (Sweden)

    Jonas Roelens

    2015-09-01

    Full Text Available Compared to the number of prosecutions for male sodomy, few cases of same-sex acts between women are known in early modern Europe. In the Southern Netherlands however, no less than 25 women were charged with this crime between c. 1400 and 1550, which means that nearly one out of ten accused sodomites in the region was a woman. Moreover, female sodomites were punished in the same way as their male counterparts. This article argues that the exceptional repression of female same-sex acts was the result of the relatively high level of liberty and visibility women enjoyed in the Southern Netherlands, compared to other regions. The more visible women were in society, the more women attracted to people of their own sex were at risk of being discovered and penalised. Zichtbare vrouwen. Vrouwelijke sodomie in de laatmiddeleeuwse en vroegmoderne Zuidelijke Nederlanden (1400-1550In vergelijking met het aantal mannelijke sodomieprocessen dat in vroegmodern Europa gevoerd werd, zijn er amper zaken bekend waarin vrouwen betrokken waren. In de Zuidelijke Nederlanden daarentegen werden niet minder dan 25 vrouwelijke sodomieten vervolgd tussen ca. 1400 en 1550. Dit betekent dat bijna één op de tien beschuldigde sodomieten in de Zuidelijke Nederlanden vrouwen waren. Bovendienwerden vrouwelijke sodomieten op dezelfde manier bestraft als hun mannelijke tegenhangers. Dit artikel stelt dat de grote mate van vrijheid en zichtbaarheid die vrouwen in de Zuidelijke Nederlanden genoten de oorzaak is van de uitzonderlijk hoge vervolgingsgraad van vrouwelijke sodomie in de regio. Hoe zichtbaarder vrouwen waren in de maatschappij, hoe groter het risico voor vrouwen die zich aangetrokken voelden tot andere vrouwen om ontdekt en bestraft te worden.

  1. GROWTH AND MOTOR DEVELOPMENT IN FETUSES OF WOMEN WITH TYPE-1 DIABETES .1. EARLY GROWTH-PATTERNS

    NARCIS (Netherlands)

    MULDER, EJH; VISSER, GHA

    1991-01-01

    Early embryonic and fetal growth were followed longitudinally in 23 women with type-1 diabetes to investigate whether there was any evidence of early growth delay and, if so, when it originated and when catch-up growth occurred. Weekly crown-rump length (CRL) measurements were taken between 7 and 14

  2. GROWTH AND MOTOR DEVELOPMENT IN FETUSES OF WOMEN WITH TYPE-1 DIABETES .1. EARLY GROWTH-PATTERNS

    NARCIS (Netherlands)

    MULDER, EJH; VISSER, GHA

    1991-01-01

    Early embryonic and fetal growth were followed longitudinally in 23 women with type-1 diabetes to investigate whether there was any evidence of early growth delay and, if so, when it originated and when catch-up growth occurred. Weekly crown-rump length (CRL) measurements were taken between 7 and 14

  3. Child abuse, early maladaptive schemas, and risky sexual behavior in college women.

    Science.gov (United States)

    Roemmele, Melissa; Messman-Moore, Terri L

    2011-05-01

    Previous research suggests that individuals abused as children are more likely to engage in risky sexual behavior during adulthood. The present study examined early maladaptive schemas as mediators of the child abuse-risky sexual behavior relationship among 653 college women. Self-report surveys assessed three forms of child abuse: Sexual, physical, and emotional, and assessed early maladaptive schemas within two domains: Disconnection/rejection and Other-Directedness. Disconnection/rejection schemas fully mediated the relation between child emotional abuse and number of sexual partners and partially mediated the relationship for sexual and physical abuse. However, when frequency of specific risky sexual acts (e.g., sex without contraception) was examined in the previous six months, only abandonment was a partial mediator. Implications for intervention and future research are discussed.

  4. Early sexual initiation and multiple sexual partners among Vietnamese women: analysis from the Multiple Indicator Cluster Survey, 2011

    Directory of Open Access Journals (Sweden)

    Dinh Thai Son

    2016-02-01

    Full Text Available Introduction: Under current HIV transmission mechanisms operating in Vietnam, women are seen as victims of their male partners. Having multiple sexual partners is one of the well-known risk factors for HIV infection. However, little is known about women's risky sexual behaviour and their vulnerability to HIV in Vietnam. This study aims to explore association between early sexual initiation and the number of lifetime sexual partners in Vietnamese women. Although the Vietnamese culture is socially conservative in this area, identifying women's risky sexual behaviour is important for the protection of women at risk of HIV and other sexually transmitted diseases. Design: A total of 8,791 women, who reported having had sexual intercourse, were included in this analysis of data from the 2011 Multiple Indicator Cluster Survey in Vietnam. Data were collected using two-stage strata sampling, first at the national level and second across six geographical regions (n=8,791. Multivariable logistic regressions describe association between early initiation of a sexual activity and lifetime multiple sexual partners. Results: Early sexual intercourse was significantly associated with having lifetime multiple sexual partners. Women who were aged 19 or younger at first sexual intercourse were over five times more likely to have multiple sexual partners, compared with women whose first sexual intercourse was after marriage; aged 10–14 years (OR=5.9; 95% CI=1.9–18.8 at first intercourse; and aged 15–19 years (OR=5.4; 95% CI=4.0–7.2 at first intercourse. There was significant association with having multiple sexual partners for women of lower household wealth and urban residence, but the association with educational attainment was not strong. Conclusions: The study results call for health and education policies to encourage the postponement of early sexual activity in young Vietnamese women as protection against risky sexual behaviour later in life.

  5. Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress.

    Science.gov (United States)

    Chen, Xue-Qin; Chen, Shu-Jiao; Liang, Wen-Na; Wang, Miao; Li, Cheng-Fu; Wang, Shuang-Shuang; Dong, Shu-Qi; Yi, Li-Tao; Li, Can-Dong

    2017-09-25

    Accumulating studies have shown that a traditional Chinese decoction Chaihu-Shugan-San produced the antidepressant-like effects in rodents including in perimenopausal. Previous studies and our preliminary study indicated that saikosaponin A, one of the main constituents of Chaihu-Shugan-San, enhanced brain-derived neurotrophic factor (BDNF) expression in rats. Herein, this study aimed to evaluate the antidepressant-like effects of saikosaponin A in perimenopausal rats exposed to chronic unpredictable mild stress (CUMS). The sucrose preference test, novelty-suppressed feeding test and forced swimming test were performed after administration of saikosaponin A for 4 weeks. Serum corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone levels, as well as hypothalamus CRH and hippocampal glucocorticoid receptor were measured. In addition, pro-inflammatory cytokines such as interleukin-1beta (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in the hippocampus were detected for evaluation of the neuroinflammation. Further, BDNF levels and its receptor TrkB were also determined. Our results indicated that four-week treatment with saikosaponin A increased sucrose preference, decreased latency to feed in the novelty-suppressed feeding test and reduced the immobility time in the forced swimming test. In addition, saikosaponin A restored the dsyregulation of HPA axis and neuroinflammation in rats exposed to CUMS. Moreover, saikosaponin A promoted BDNF-TrkB signaling in the hippocampus. This study demonstrates that saikosaponin A produced the antidepressant-like effects in rats, which may be mediated by restoration of neuroendocrine, neuroinflammation and neurotrophic systems in the hippocampus during perimenopausal. Copyright © 2017. Published by Elsevier B.V.

  6. Obesity prevalence in a cohort of women in early pregnancy from a neighbourhood perspective

    Directory of Open Access Journals (Sweden)

    Alricsson Marie

    2009-08-01

    Full Text Available Abstract Background The evidence of an association between neighbourhood deprivation and overweight is established for different populations. However no previous studies on neighbourhood variations in obesity in pregnant women were found. In this study we aimed to determine whether obesity during early pregnancy varied by neighbourhood economic status. Methods A register based study on 94,323 primiparous pregnant women in 586 Swedish neighbourhoods during the years 1992–2001. Multilevel technique was used to regress obesity prevalence on socioeconomic individual-level variables and the neighbourhood economic status. Five hundred and eighty-six neighbourhoods in the three major cities of Sweden, Stockholm, Göteborg and Malmö, during 1992–2001, were included. The majority of neighbourhoods had a population of 4 000–10 000 inhabitants. Results Seven per cent of the variation in obesity prevalence was at the neighbourhood level and the odds of being obese were almost doubled in poor areas. Conclusion Our findings supports a community approach in the prevention of obesity in general and thus also in pregnant women.

  7. Laparoscopic compared with open radical hysterectomy in obese women with early-stage cervical cancer.

    Science.gov (United States)

    Park, Jeong-Yeol; Kim, Dae-Yeon; Kim, Jong-Hyeok; Kim, Yong-Man; Kim, Young-Tak; Nam, Joo-Hyun

    2012-06-01

    To compare the surgical and oncological outcomes of laparoscopic radical hysterectomy and open radical hysterectomy in obese women with early-stage cervical cancer. The medical records of 166 patients with stage IA2-IIA2 cervical cancer and a body mass index of at least 30 who underwent laparoscopic radical hysterectomy (n=54) or open radical hysterectomy (n=112) at the Asan Medical Center between 1998 and 2011 were reviewed. None of the patients in the laparoscopic radical hysterectomy group required conversion to laparotomy. The resection margin was negative in 98.1% of the laparoscopic radical hysterectomy group and 98.2% of the open radical hysterectomy group (P=.976). No difference between the two groups was observed in terms of operating time, perioperative hemoglobin level change, transfusion requirement, or the number of retrieved lymph nodes. Compared with open radical hysterectomy, laparoscopic radical hysterectomy was associated with a significant reduction in the following: interval to return of bowel movements (2 days compared with 2.7 days, Plaparoscopic radical hysterectomy group and 85% for the open radical hysterectomy group (P=.682). The 5-year overall survival rate was 97% for the laparoscopic radical hysterectomy group and 90% for the open radical hysterectomy group (P=.220). Laparoscopic radical hysterectomy was a preferred alternative to open radical hysterectomy in the present cohort of obese women with early-stage cervical cancer because it is associated with a more favorable surgical outcome without compromising survival outcomes. II.

  8. Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome

    Directory of Open Access Journals (Sweden)

    Mohammadi Afshin

    2011-10-01

    Full Text Available Background Polycystic ovary syndrome (PCOS is the most common endocrinopathy in women of childbearing age, and it seems better to consider it as an ovarian manifestation of metabolic syndrome. The aim of the current study was to evaluate early atherosclerotic findings in patients with PCOS. Methods We enrolled 46 women with PCOS and 45 normal control subjects who were referred to our hospital's endocrinology outpatient clinic. Carotid intima media thickness (CIMT and flow-mediated dilatation (FMD were performed in both cases and matched controls. Results Patients with PCOS showed an increased mean CIMT (0.63 ± 0.16 mm when compared with the control subjects (0.33 ± 0.06 mm. This difference was statistically significant (p = 0.001. The mean FMD in young patients with PCOS was 10.07 ± 1.2%, while it was 6.5 ± 2.06% in normal subjects. This difference was also statistically significant (p = 0.001. Conclusion Our findings suggest that PCOS is related with early atherosclerotic findings.

  9. Implementation of program of prevention and early detection of osteoporosis among women of Primorsko-goranska County.

    Science.gov (United States)

    Janković, Suzana; Kresina, Helena Glibotić; Zezelj, Sandra Pavicić; Kresina, Sandro

    2011-09-01

    The aim of this paper is to present preliminary data of Program of prevention and early detection of osteoporosis among women in Primorsko-goranska County. Osteoporosis is recognized as a public health problem for which clearly preventive measures are defined. Measurement of bone density was done by ultrasound densitometry of the calcaneus among women aged from 45 to 69 years old. 688 women were examined and they were classified in five five-year age groups. The women with the osteoporosis (T-score educative booklet with advices for healthy nutrition and physical activity. Implementation of this program indicated the importance of proper lifestyle in the prevention of osteoporosis. Average T-scores of all five groups of women show that osteopenia occurs also in the youngest ones. This indicates the need for a systematic approach to preventing osteoporosis through education of women including younger ones and creating conditions for organized physical activities at the community level.

  10. Chinese primiparous women's experiences of early motherhood: factors affecting maternal role competence.

    Science.gov (United States)

    Ngai, Fei-Wan; Chan, Sally W C; Holroyd, Eleanor

    2011-05-01

    The aim of this study was to explore Chinese women's perceptions of maternal role competence and factors contributing to maternal role competence during early motherhood. Developing a sense of competence and satisfaction in the maternal role are considered critical components in maternal adaptation, which have a significant impact on parenting behaviours and the psychosocial development of the child. However, qualitative studies that address maternal role competence are limited in the Chinese population. This was an exploratory descriptive study. A purposive sample of 26 Chinese primiparous mothers participated in a childbirth psychoeducation programme and was interviewed at six weeks postpartum. Data were analysed using content analysis. Women perceived a competent mother as being able to make a commitment to caring for the physical and emotional well-being of child, while cultivating appropriate values for childhood. Personal knowledge and experience of infant care, success in breastfeeding, infant's well-being, availability of social support and contradictory information from various sources were major factors affecting maternal role competency. The findings highlight the importance of understanding Chinese cultural attitudes to childrearing and maternal role competence. New Chinese mothers need information on child care, positive experiences of infant care, social support and consistent information to enhance their maternal role competency. Recommendations are made for Chinese culturally specific guidelines and healthcare delivery interventions to enhance maternal role competence in early motherhood. Nursing and midwifery care should always take into account the cultural beliefs and enable adaptation of traditional postpartum practices. Providing consistent information and positive experience on parenting skills and infant behaviour as well as enhancing effective coping strategies could strengthen Chinese women's maternal role competency. © 2011 Blackwell

  11. Transformation and time-out: the role of alcohol in identity construction among Scottish women in early midlife.

    Science.gov (United States)

    Emslie, Carol; Hunt, Kate; Lyons, Antonia

    2015-05-01

    Despite the increase in drinking by women in early midlife, little alcohol research has focused on this group. We explore how alcohol is associated with the construction of gender identities among women aged 30-50 years in the west of Scotland, United Kingdom. We draw on qualitative data from 11 focus groups (five all-female, six mixed-sex) with pre-existing groups of friends and work colleagues in which women and men discuss their drinking behaviours. Analysis demonstrated how alcohol represented a time and space away from paid and unpaid work for women in a range of domestic circumstances, allowing them to relax and unwind. While women used alcohol to construct a range of identities, traditional notions of femininity remained salient (e.g. attention to appearance, drinking 'girly' drinks). Drinking enabled women to assert their identity beyond the roles and responsibilities often associated with being a woman in early midlife. For example, some respondents with young children described the transformative effects of excessive drinking which allowed them to return temporarily to a younger, carefree version of themselves. Thus, our data suggest that women's drinking in early midlife revolves around notions of 'idealised' femininity but simultaneously represents a way of achieving 'time out' from traditional female responsibilities such as caring for others. We consider these findings within a broader social and cultural context including alcohol marketing, domestic roles and motherhood and their implications for health promotion.

  12. Well-Being and Diabetes Management in Early Pregnant Women with Type 1 Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Karolina Linden

    2016-08-01

    Full Text Available This paper explores well-being and diabetes management in women with type 1 diabetes mellitus (DM in early pregnancy and investigates associations among perceived well-being, diabetes management, and maternal characteristics. Questionnaires were answered by 168 Swedish women. Correlation analyses were conducted with Spearman’s correlation coefficient (rs. The women reported relatively high scores of self-efficacy in diabetes management (SWE-DES-10: 3.91 (0.51 and self-perceived health (excellent (6.5%, very good (42.3%, good (38.7%, fair (11.3% and poor (1.2%. Moderate scores were reported for general well-being (WBQ-12: 22.6 (5.7 and sense of coherence (SOC-13: 68.9 (9.7, moderate/low scores for hypoglycemia fear (SWE-HFS 26.6 (11.8 and low scores of diabetes-distress (SWE-PAID-20 27.1 (15.9. A higher capability of self-efficacy in diabetes management showed positive correlations with self-perceived health (rs = −0.41, p < 0.0001 and well-being (rs = 0.34, p < 0.0001 as well as negative correlations with diabetes distress (rs = −0.51, p < 0.0001 and hypoglycemia worries (rs = −0.27, p = 0.0009. Women with HbA1c levels of ≤48 mmL/mol scored higher in the subscales “goal achievement” in SWE-DES (p = 0.0028 and “comprehensibility” in SOC (p = 0.016. Well-being and diabetes management could be supported by strengthening the women’s capability to achieve glycemic goals and their comprehensibility in relation to the treatment. Further studies are needed to test this.

  13. Role of Ovarian Function Suppression in Premenopausal Women with Early Breast Cancer

    Science.gov (United States)

    2016-01-01

    Historically, endocrine therapy for breast cancer began with ovarian ablation (OA) for the treatment of premenopausal patients. After the identification of estrogen receptors and the development of many antiestrogens, tamoxifen has been approved and used as the standard endocrine therapy for hormonal receptor (HR)-positive premenopausal patients to date. With the development of luteinizing hormone-releasing hormone agonists, the paradigm of endocrine therapy for premenopausal women with HR-positive breast cancer began to change from OA to ovarian function suppression (OFS). To date, the indication for OFS was limited to those premenopausal patients with HR-positive breast cancer who were unable to use tamoxifen as the primary adjuvant endocrine therapy. However, following the definitive demonstration of the therapeutic role of OFS added to tamoxifen or aromatase inhibitor after chemotherapy in large randomized trials, such as Tamoxifen and Exemestane Trial or Suppression of Ovarian Function Trial, the American Society of Clinical Oncology guidelines for the use of endocrine therapy in premenopausal HR-positive breast cancer were recently updated to recommend OFS in high-risk patients who required adjuvant chemotherapy. In contrast, the role of OFS to protect ovarian function during chemotherapy in premenopausal women has remained controversial, and some evidence showing the protective effect of OFS on the ovaries during chemotherapy as well as its therapeutic effect for breast cancer in premenopausal women with HR-negative breast cancer was recently published. Further evaluation is necessary to determine its exact role. In conclusion, the role of OA or OFS has been evolving, not only to improve the efficacy of breast cancer treatment, but also to preserve ovary function. OFS remains a main strategy for premenopausal women with HR-positive early breast cancer, though its exact role should be determined in further studies. PMID:28053622

  14. Study of early atherosclerotic markers in women with polycystic ovary syndrome

    Directory of Open Access Journals (Sweden)

    Ritu Karoli

    2012-01-01

    Full Text Available Objective: Women with polycystic ovary syndrome (PCOS may represent a large underappreciated segment of female population who is at increased cardiovascular risk because of the presence of cluster of metabolic abnormalities. The aim of our study was to assess atherosclerotic risk factors in women with PCOS. Materials and Methods: In a cross-sectional study, 50 women with PCOS and 50 age and weight-matched healthy controls were enrolled. Endothelial dysfunction by flow-mediated dilatation (FMD of brachial artery, highly sensitive C-reactive protein (hs CRP, and carotid intima media thickness (CIMT were measured in both cases and control groups. Results: The mean age of women with PCOS was 26.82 ± 3.26 years and Body-mass index (BMI of 26.2 ± 4.8 kg/ m 2 . Thirty-six (72% patients were overweight or obese,54% had central obesity and 12% had impaired glucose tolerance. Among the markers of atherosclerosis, hsCRP levels were nonsignificantly higher in patients with PCOS than in controls. The FMD was 12.18 ± 2.3% vs 8.3 ± 2.23% in patients with PCOS and controls respectively (P=0.01. CIMT was significantly different in two study groups (0.68 ± 0.11 in PCOS vs 0.52 ± 0.02 in normal subjects, (P=0.01. FMD had significant negative correlation with homeostasis model assessment (HOMA index (r = −0.32, P=0.02 and hs CRP (r = −0.37, P=0.04 while hs CRP was correlated with BMI (r = 0.54, P=0.005, HOMA (r = 0.38, P=0.02 and FMD (r = -0.33, P=0.01. CIMT was significantly different in women with PCOS and control subjects, and it had significant correlation with age (r = 0.42, P=0.03, BMI (r = 0.36, P=0.01, waist circumference (r = 0.52, P=0.001 and HOMA (r = 0.31, P=0.04. Conclusion: Women with PCOS definitely have increased risk for future cardiovascular events. Clinicians should consider early cardiovascular screening and interventions to control all modifiable cardiovascular risk factors.

  15. Factors influencing behavioral intention to undergo Papanicolaou testing in early adulthood: Comparison of Japanese and Korean women.

    Science.gov (United States)

    Kang, Kyung-Ah; Kim, Shin-Jeong; Kaneko, Noriyo

    2017-08-23

    In this study, we identified the factors influencing behavioral intention to undergo Papanicolaou testing among Japanese and Korean women in early adulthood. Their behavioral intentions were compared in this cross-sectional descriptive study. In total, 887 women (Japanese = 498, Korean = 389) aged 20-39 years participated in this study. Using a self-report questionnaire, knowledge, attitudes, subjective norm, perceived behavioral control, and behavioral intention were surveyed. There were significant differences between Japanese and Korean women's scores on all main variables. For Japanese women, all the variables moderately correlated with behavioral intention. In comparison, for Korean women, all independent variables, except for knowledge, moderately correlated with behavioral intention. Through a multiple regression analysis, age, undergoing Papanicolaou testing, attitudes, subjective norm, and perceived behavioral control were identified as significant predictors of behavioral intention among Japanese women. Among Korean women, job status, undergoing a Papanicolaou test, attitudes, subjective norm, and perceived behavioral control were demonstrated as significant predictors of behavioral intention. Health professionals should consider these factors to encourage Papanicolaou testing in women in early adulthood. © 2017 John Wiley & Sons Australia, Ltd.

  16. Opting Out and Leaning In: The Life Course Employment Profiles of Early Baby Boom Women in the United States.

    Science.gov (United States)

    García-Manglano, Javier

    2015-12-01

    Most literature on female employment focuses on the intersection between women's labor supply and family events such as marriage, divorce, or childbearing. Even when using longitudinal data and methods, most studies estimate average net effects over time and assume homogeneity among women. Less is known about diversity in women's cumulative work patterns over the long run. Using group-based trajectory analysis, I model the employment trajectories of early Baby Boom women in the United States from ages 20 to 54. I find that women in this cohort can be classified in four ideal-type groups: those who were consistently detached from the labor force (21 %), those who gradually increased their market attachment (27 %), those who worked intensely in young adulthood but dropped out of the workforce after midlife (13 %), and those who were steadily employed across midlife (40 %). I then explore a variety of traits associated with membership in each of these groups. I find that (1) the timing of family events (marriage, fertility) helps to distinguish between groups with weak or strong attachment to the labor force in early adulthood; (2) external constraints (workplace discrimination, husband's opposition to wife's work, ill health) explain membership in groups that experienced work trajectory reversals; and (3) individual preferences influence labor supply across women's life course. This analysis reveals a high degree of complexity in women's lifetime working patterns, highlighting the need to understand women's labor supply as a fluid process.

  17. Exercise for health for early postmenopausal women: a systematic review of randomised controlled trials.

    Science.gov (United States)

    Asikainen, Tuula-Maria; Kukkonen-Harjula, Katriina; Miilunpalo, Seppo

    2004-01-01

    Women who pass menopause face many changes that may lead to loss of health-related fitness (HRF), especially if sedentary. Many exercise recommendations are also relevant for early postmenopausal women; however, these may not meet their specific needs because the recommendations are based mainly on studies on men. We conducted a systematic review for randomised, controlled exercise trials on postmenopausal women (aged 50 to 65 years) on components of HRF. HRF consists of morphological fitness (body composition and bone strength), musculoskeletal fitness (muscle strength and endurance, flexibility), motor fitness (postural control), cardiorespiratory fitness (maximal aerobic power, blood pressure) and metabolic fitness (lipid and carbohydrate metabolism). The outcome variables chosen were: bodyweight; proportion of body fat of total bodyweight (F%); bone mineral density (BMD); bone mineral content (BMC); various tests on muscle performance, flexibility, balance and coordination; maximal oxygen consumption (V-dotO(2max)); resting blood pressure (BP); total cholesterol (TC); high-density lipoprotein-cholesterol; low-density lipoprotein-cholesterol; triglycerides; blood glucose and insulin. The feasibility of the exercise programme was assessed from drop-out, attendance and injury rates. Twenty-eight randomised controlled trials with 2646 participants were assessed. In total, 18 studies reported on the effects of exercise on bodyweight and F%, 16 on BMD or BMC, 11 on muscular strength or endurance, five on flexibility, six on balance or coordination, 18 on V-dotO(2max), seven on BP, nine on lipids and two studies on glucose an one on insulin. Based on these studies, early postmenopausal women could benefit from 30 minutes of daily moderate walking in one to three bouts combined with a resistance training programme twice a week. For a sedentary person, walking is feasible and can be incorporated into everyday life. A feasible way to start resistance training is to

  18. Characterization of perimenopausal bone loss: a prospective study.

    Science.gov (United States)

    Recker, R; Lappe, J; Davies, K; Heaney, R

    2000-10-01

    This study characterized the change in bone mass, bone markers, pituitary/gonadal hormones, vitamin D, parathyroid hormone, and anthropometric variables in a cohort of healthy women as they passed through normal menopause. We recruited 75 women > 46 years old who had premenopausal estradiol (E2) and gonadotropin levels and regular menses. During 9.5 years of observation, 54 experienced normal menopause (PM group) and 21 remained estrogen replete (ER group). Before the beginning of the menopausal drop and after its completion, the slope of bone mass on time in the PM group was 0% for the spine, -0.61% per year for the total body, and -0.45 % per year for the femoral neck. Designating these losses as "age related," there were 0, 4.88, and 3.40% losses for spine, total body bone mineral (TBBM), and femoral neck, respectively, in the 8-year period for which the data were analyzed. Across menopause, we found a sigmoid pattern of bone loss in the PM group beginning about 2-3 years before the last menses and ending about 3-4 years after the last menses. The total estrogen-deprivation bone losses were 10.50, 7.73, and 5.30% for the spine, TBBM, and femoral neck, respectively. In the ER group, we found a 0, 0.59, and 0.93% per year loss in spine, TBBM, and femoral neck, respectively. Serum osteocalcin rose 77%, serum total alkaline phosphatase rose 34%, and urinary hydroxyproline/creatinine (Hypro/Cr) ratio rose 44% in the PM group, while remaining stable in the ER group. We conclude that menopausal bone loss is a composite of loss caused by estrogen deprivation and age per se for the hip and total body, but is caused by estrogen deprivation alone for the spine.

  19. The Experience of Robotic-Assisted Laparoscopic Hysterectomy for Women Treated for Early-Stage Endometrial Cancer

    DEFF Research Database (Denmark)

    Herling, Suzanne Forsyth; Palle, Connie; Moeller, Ann M

    2016-01-01

    BACKGROUND: An increasing number of women are offered robotic-assisted laparoscopic hysterectomy as treatment for early-stage endometrial cancer in the developed world. OBJECTIVE: The aim of this study was to explore how women diagnosed with early-stage endometrial cancer experienced robotic......-assisted laparoscopic hysterectomy. METHODS: Semistructured interviews were carried out with 12 women, and interview data were analyzed by qualitative content analysis. RESULTS: Four overarching themes emerged: "surgery was a piece of cake," "recovering physically after surgery," "going from being off guard to being...... on guard," and "preparing oneself by seeking information." The women had confidence in the robotic technique and experienced fast recovery after robotic-assisted laparoscopic hysterectomy; however, they had uncertainties and unanswered questions concerning the postoperative course. Shortly after discharge...

  20. Manifestations of somatic disturbances in early postmenopause in women after physiological and surgical menopause

    Directory of Open Access Journals (Sweden)

    Ninčić Dejan

    2006-01-01

    Full Text Available Background/Aim. The most common secondary manifestations of menopause are clinical manifestations of estrogen deficiency. They could be early and late. The aim of this study was to compare manifestations of somatic disturbances in early postmenopause in women after physiological and surgical menopause. Methods. This prospective study included 60 women, age 41-55 years, divided into two groups: physiological (30 of them and surgically induced menopause. For every subject a special evidence list, consisting of the disease history questions, physical and gynecology examination as well as dates about physiological variables (arterial tension, height, weight, and body-mass index and laboratory examination was formed. The values of arterial blood pressure, body height, body mass, body mass index (BMI, and lipid status were determined and gynecological examinations were performed in each patient. Results. The most frequent symptoms in both groups were vasomotor ones. Headache was the more intensive sign in the group after induced menopause. Extra systolic heart excursion was a common symptom in both study groups. Arterial tension, regardless of the type of menopause, was in the physiological range. The frequent organic signs of menopause, more intensive in the group after induced menopause, were genitourinary and skin atrophy. An analysis of the BMI showed that the women in both groups were obese (BMI > 25. The lipids analysis confirmed the predomination of hyperlipoproteinemia type IIa in the group with physiologic menopause and type IIb after induced menopause. Conclusion. The dominant signs of menopausal syndrome were vasomotor and bone-joint symptoms, more frequent in the group after induced menopause. There were no statistically significant differences between the study groups according to the genitourinary atrophy and other signs of aging. Menopausal hormonal changes, regardless of the way of menopause developing, increase the risk for

  1. Differences in Early Maladaptive Schemas in a Sample of Alcohol and Opioid Dependent Women: Do Schemas Vary Across Disorders?

    Science.gov (United States)

    Shorey, Ryan C.; Stuart, Gregory L.; Anderson, Scott

    2012-01-01

    Research suggests that there may be differences between individuals diagnosed with alcohol dependence and individuals diagnosed with opioid dependence on co-morbid mental health problems (e.g., personality disorders, mood disorders, etc.). The current study examined whether there were differences in early maladaptive schemas, which are theorized to underlie mental health problems, among women diagnosed with alcohol dependence or opioid dependence who were seeking treatment for their substance use (N = 420). Results showed that opioid dependent women scored higher on 2 of the 18 early maladaptive schemas, particularly the schemas of dependence and punitiveness. Overall, these findings suggest that early maladaptive schemas may be largely consistent across women diagnosed with alcohol or opioid dependence. Implications of these findings for future research and treatment are discussed. PMID:23494129

  2. Recruitment and Early Retention of Women with Advanced Breast Cancer in a Complementary and Alternative Medicine Trial

    Directory of Open Access Journals (Sweden)

    Alla Sikorskii

    2011-01-01

    Full Text Available More than 80% of women with breast cancer are now reported to be using complementary and alternative medicine (CAM therapies during conventional treatment. A randomized clinical trial (RCT of reflexology with late stage breast cancer patients serves as the data source for this article. The purposes were to investigate: (i reasons for refusal to participate in a RCT of reflexology; (ii the differences between those who completed the baseline interview and those who dropped out before baseline; and (iii the utility of the Palliative Prognostic Score (PPS as a prognostic screening tool in minimizing early attrition (before baseline from the trial. Eligible women (N = 400 approached at 12 cancer centers in the Midwest had advanced breast cancer, were on chemotherapy or hormonal therapy, and had a PPS of 11 or less. Comparisons of those who dropped out early (N = 33 to those who stayed in the trial (N = 240 were carried out using Wilcoxon rank, t-, chi-squared and Fisher's exact tests. The reasons of being “too sick” or “overwhelmed” were given by less than 12% of the women who refused to participate. There was a higher early dropout rate among black women compared to other (primarily white women (P = .01. Cancer recurrence and metastasis, age, and the PPS were not predictive of early retention of women. Specialized techniques may be needed to ensure black women remain in the trial once consented. Women with advanced disease were likely to enter and remain in the trial despite deterioration in health.

  3. Preconception and early pregnancy maternal haemodynamic changes in healthy women in relation to pregnancy viability.

    Science.gov (United States)

    Foo, F L; Collins, A; McEniery, C M; Bennett, P R; Wilkinson, I B; Lees, C C

    2017-05-01

    . Similarly, between the groups, there were no differences in pregnancy adaptation with similar trends in cardiovascular function changes from pre-pregnancy to 6 weeks gestation. Whilst this is the first study to investigate preconception and early pregnancy haemodynamic and arterial function in relation to viability, the relatively modest number of miscarriages may not be sufficient to show subtle differences in haemodynamic changes if these were present. This study suggests that pre-pregnancy haemodynamic and arterial function is unlikely to be the causal link between miscarriages and future cardiovascular disease. Our findings suggests that factors other than the presence of a viable embryo drive cardiovascular changes in early pregnancy. This study raises new questions about miscarriages as an independent risk event which predisposes women to increased cardiovascular risk later in life. The investigators are funded by NIHR Imperial BRC, NIHR Cambridge BRC, Action Medical Research, Imperial College Healthcare Charity and Tommy's Charity. We acknowledge the loan of ultrasound equipment from Samsung Medison (South Korea)/MIS Ltd and provision of fertility monitors from SPD Development Company Ltd (Bedford, UK). There are no competing interests. C.C.L. is supported by the UK National Institute for Health Research Biomedical Research Centre based at Imperial College Healthcare National Health Service Trust and Imperial College London. N/A.

  4. Robotic-assisted laparoscopic hysterectomy seems safe in women with early-stage endometrial cancer

    DEFF Research Database (Denmark)

    Herling, Suzanne Forsyth; Havemann, Maria Cecilie; Palle, Connie

    2015-01-01

    INTRODUCTION: Robotic surgery is increasingly used in the management of endometrial cancer; and although it is known that minimally invasive surgery reduces post-operative morbidity, the outcomes of this novel treatment should be monitored carefully. The aim of this study was to examine...... the incidence of complications according to the Clavien-Dindo scale after robotic-assisted laparoscopic hysterectomy (RALH) for early-stage endometrial cancer and atypical complex hyperplasia. The Clavien-Dindo scale grades the severity of complications. METHODS: This was a retrospective, descriptive cohort...... study of 235 women with endometrial cancer or atypical complex hyperplasia who had RALH. Surgeries were stratified into two groups: with or without pelvic lymphadenectomy. RESULTS: A total of 6% developed a grade 3 or higher complication with no significant difference (p = 0.24) between the groups...

  5. Expanding Women's Rural Medical Work in Early Modern Brittany: The Daughters of the Holy Spirit

    Science.gov (United States)

    McHugh, Tim

    2012-01-01

    During the eighteenth century, orders of nursing sisters took on an expanded role in the rural areas of Brittany. This article explores the impact of religious change on the medical activities of these women. While limits were placed on the medical practice of unlicensed individuals, areas of new opportunity for nuns as charitable practitioners were created by devout nobles throughout the eighteenth century. These nuns provided comprehensive care for the sick poor on their patrons' estates, acting not only as nurses, but also in lieu of physicians, surgeons, and apothecaries. This article argues that the medical knowledge and expertise of these sisters from the nursing orders were highly valued by the elites of early modern Brittany. PMID:21724643

  6. Expanding women's rural medical work in early modern Brittany: the Daughters of the Holy Spirit.

    Science.gov (United States)

    McHugh, Tim

    2012-07-01

    During the eighteenth century, orders of nursing sisters took on an expanded role in the rural areas of Brittany. This article explores the impact of religious change on the medical activities of these women. While limits were placed on the medical practice of unlicensed individuals, areas of new opportunity for nuns as charitable practitioners were created by devout nobles throughout the eighteenth century. These nuns provided comprehensive care for the sick poor on their patrons' estates, acting not only as nurses, but also in lieu of physicians, surgeons, and apothecaries. This article argues that the medical knowledge and expertise of these sisters from the nursing orders were highly valued by the elites of early modern Brittany.

  7. Association between whole-blood polyunsaturated fatty acids in pregnant women and early fetal weight

    DEFF Research Database (Denmark)

    Carlsen, Katrine; Pedersen, L.; Bønnelykke, K.

    2013-01-01

    Background/objectives:Studies suggest that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFA) in pregnancy have an impact on birth weight, but only few have investigated the effect on early fetal growth. The objective of the study was to investigate the association between levels of PUFA...... in maternal blood in gestational week 24 and biometric measures and estimated fetal weight in gestational week 20.Subjects/methods:In the COPSAC cohort, whole-blood fatty acid composition (a biomarker of PUFA intake) from 583 women in week 24 was analyzed by gas chromatography. Biometric data (head...... by multivariable-adjusted linear regression analyses. Results:There was a wide range in maternal blood DHA, which varied from 1.8 to 6.9% depending on socioeconomic status, smoking and body mass index. After adjusting for these variables, no association was observed between any of the assessed PUFA components...

  8. Early follicular testosterone level predicts preference for masculinity in male faces - but not for women taking hormonal contraception.

    Science.gov (United States)

    Bobst, Cora; Sauter, Sabine; Foppa, Andrina; Lobmaier, Janek S

    2014-03-01

    It has been shown that women's preference for masculinity in male faces changes across the menstrual cycle. Preference for masculinity is stronger when conception probability is high than when it is low. These findings have been linked to cyclic fluctuations of hormone levels. The purpose of the present study is to further investigate the link between gonadal steroids (i.e. testosterone, estradiol, and progesterone) and masculinity preference in women, while holding the cycle phase constant. Sixty-two female participants were tested in their early follicular cycle phase, when conception probability is low. Participants were shown face pairs and where asked to choose the more attractive face. Face pairs consisted of a masculinized and feminized version of the same face. For naturally cycling women we found a positive relationship between saliva testosterone levels and masculinity preference, but there was no link between any hormones and masculinity preference for women taking hormonal contraception. We conclude that in naturally cycling women early follicular testosterone levels are associated with masculinity preference. However, these hormonal links were not found for women with artificially modified hormonal levels, that is, for women taking hormonal contraception. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer

    Directory of Open Access Journals (Sweden)

    Stefano Gonnelli

    2008-12-01

    Full Text Available Stefano Gonnelli1, Roberto Petrioli21Department of Internal Medicine, Endocrine-Metabolic Science and Biochemistry, University of Siena, Italy (Dir. R. Nuti.; 2Department of Human Pathology and Oncology, Medical Oncology Section, University of Siena, Italy (Dir. G. FranciniAbstract: The third-generation aromatase inhibitors (AIs, letrozole, anastrozole and exemestane, are becoming the first choice endocrine drugs for post-menopausal women with breast cancer, since they present greater efficacy when compared with tamoxifen in both adjuvant and metastatic setting. In particular, several large and well designed trials have suggested an important role for AIs in the adjuvant treatment of postmenopausal women with estrogen-receptor positive breast cancer either in the upfront, sequential or extended adjuvant mode. Overall, AIs are associated with a small but significant improvement in disease free survival. The expanding use of AIs in the treatment of early breast cancer means that individual patients will be exposed to the agents for longer durations, making it increasingly important to establish their long-term safety. This review focused on the effects of AIs on bone metabolism, serum lipids and cardiovascular risk. AIs have adverse effects on bone turnover with a reduction of bone mineral density and an increase in the rate of fragility fractures. With respect to tamoxifen AIs present lower thrombotic risk and a less favorable impact on lipid profile, whereas the true effects on cardiovascular risk still remain to be clarified. An adequate monitoring of bone mineral density (BMD and lipid profile could be recommended for post-menopausal women candidate to AIs.Keywords: breast cancer, aromatase inhibitors, bone loss, lipids, cardiovascular risk

  10. Quality of life of Lithuanian women with early stage breast cancer

    Directory of Open Access Journals (Sweden)

    Ostapenko Valerijus

    2007-06-01

    Full Text Available Abstract Background In the last decades, there have been no studies carried out in Lithuania on the quality of life of breast cancer patients. The aim of the present study was to evaluate changes in the quality of life of Lithuanian women with the early stage of breast cancer nine months after surgery and its dependence on surgical strategy, adjuvant chemotherapy and the social and demographic status of the patients. Methods Seventy-seven patients with early stage breast cancer filled in the FACT-An questionnaire twice: one week and nine months after the surgery. The main age of the patients was 53.1 ± 10.6 years. We distinguished the mastectomy group and breast conserving treatment (BCT group with/without chemotherapy. The groups were identical in their social and demographic status (age, education, occupation and marital status. Changes in the quality of life in these groups were compared nine months after surgery. Results Nine months after surgery, the overall quality of life was found worse in both mastectomy and BCT groups. Changes were induced by the worsening of the emotional and social well-being. The quality of life became worse in the mastectomy plus chemotherapy sample. No changes were detected in the mastectomy group without chemotherapy. In addition, the multivariate analysis showed that the marital status was quite a significant determinant of the functional well-being. Conclusion Nine months after surgery, the study revealed a worsening of the overall quality of life in both groups of patients – those who had undergone mastectomy and BCT. The quality of life became considerably worse in the mastectomy plus chemotherapy group. Marital status was found to exert the most considerable influence on the women's quality of life in comparison with other social and demographic factors.

  11. Quality of life of Lithuanian women with early stage breast cancer.

    Science.gov (United States)

    Bulotiene, Giedre; Veseliunas, Jonas; Ostapenko, Valerijus

    2007-06-26

    In the last decades, there have been no studies carried out in Lithuania on the quality of life of breast cancer patients. The aim of the present study was to evaluate changes in the quality of life of Lithuanian women with the early stage of breast cancer nine months after surgery and its dependence on surgical strategy, adjuvant chemotherapy and the social and demographic status of the patients. Seventy-seven patients with early stage breast cancer filled in the FACT-An questionnaire twice: one week and nine months after the surgery. The main age of the patients was 53.1 +/- 10.6 years. We distinguished the mastectomy group and breast conserving treatment (BCT) group with/without chemotherapy. The groups were identical in their social and demographic status (age, education, occupation and marital status). Changes in the quality of life in these groups were compared nine months after surgery. Nine months after surgery, the overall quality of life was found worse in both mastectomy and BCT groups. Changes were induced by the worsening of the emotional and social well-being. The quality of life became worse in the mastectomy plus chemotherapy sample. No changes were detected in the mastectomy group without chemotherapy. In addition, the multivariate analysis showed that the marital status was quite a significant determinant of the functional well-being. Nine months after surgery, the study revealed a worsening of the overall quality of life in both groups of patients--those who had undergone mastectomy and BCT. The quality of life became considerably worse in the mastectomy plus chemotherapy group. Marital status was found to exert the most considerable influence on the women's quality of life in comparison with other social and demographic factors.

  12. Robotic-assisted laparoscopic hysterectomy seems safe in women with early-stage endometrial cancer

    DEFF Research Database (Denmark)

    Herling, Suzanne Forsyth; Havemann, Maria Cecilie; Palle, Connie;

    2015-01-01

    INTRODUCTION: Robotic surgery is increasingly used in the management of endometrial cancer; and although it is known that minimally invasive surgery reduces post-operative morbidity, the outcomes of this novel treatment should be monitored carefully. The aim of this study was to examine the incid......INTRODUCTION: Robotic surgery is increasingly used in the management of endometrial cancer; and although it is known that minimally invasive surgery reduces post-operative morbidity, the outcomes of this novel treatment should be monitored carefully. The aim of this study was to examine...... the incidence of complications according to the Clavien-Dindo scale after robotic-assisted laparoscopic hysterectomy (RALH) for early-stage endometrial cancer and atypical complex hyperplasia. The Clavien-Dindo scale grades the severity of complications. METHODS: This was a retrospective, descriptive cohort....... CONCLUSION: The types and frequency of complications observed in this study resemble those reported in similar studies of RALH for malignant gynaecologic conditions. Health-care professionals treating and caring for women with early-stage endometrial cancer should know of the types and frequency of post...

  13. Whole-exome sequencing predicted cancer epitope trees of 23 early cervical cancers in Chinese women.

    Science.gov (United States)

    Li, Xia; Huang, Hailiang; Guan, Yanfang; Gong, Yuhua; He, Cheng-Yi; Yi, Xin; Qi, Ming; Chen, Zhi-Ying

    2017-01-01

    Emerging evidence suggest that the heterogeneity of cancer limits the efficacy of immunotherapy. To search for optimal therapeutic targets for enhancing the efficacy, we used whole-exome sequencing data of 23 early cervical tumors from Chinese women to investigate the hierarchical structure of the somatic mutations and the neo-epitopes. The putative neo-epitopes were predicted based on the mutant peptides' strong binding with major histocompatibility complex class I molecules. We found that each tumor carried an average of 117 mutations and 61 putative neo-epitopes. Each patient displayed a unique phylogenetic tree in which almost all subclones harbored neo-epitopes, highlighting the importance of individual neo-epitope tree in determination of immunotherapeutic targets. The alterations in FBXW7 and PIK3CA, or other members of the significantly altered ubiquitin-mediated proteolysis and extracellular matrix receptor interaction related pathways, were proposed as the earliest changes triggering the malignant progression. The neo-epitopes involved in these pathways, and located at the top of the hierarchy tree, might become the optimal candidates for therapeutic targets, possessing the potential to mediate T-cell killing of the descendant cells. These findings expanded our understanding in early stage of cervical carcinogenesis and offered an important approach to assist optimizing the immunotherapeutic target selection.

  14. Aerobic exercise and yoga improve neurocognitive function in women with early psychosis.

    Science.gov (United States)

    Lin, Jingxia; Chan, Sherry Kw; Lee, Edwin Hm; Chang, Wing Chung; Tse, Michael; Su, Wayne Weizhong; Sham, Pak; Hui, Christy Lm; Joe, Glen; Chan, Cecilia Lw; Khong, P L; So, Kwok Fai; Honer, William G; Chen, Eric Yh

    2015-01-01

    Impairments of attention and memory are evident in early psychosis, and are associated with functional disability. In a group of stable, medicated women patients, we aimed to determine whether participating in aerobic exercise or yoga improved cognitive impairments and clinical symptoms. A total of 140 female patients were recruited, and 124 received the allocated intervention in a randomized controlled study of 12 weeks of yoga or aerobic exercise compared with a waitlist group. The primary outcomes were cognitive functions including memory and attention. Secondary outcome measures were the severity of psychotic and depressive symptoms, and hippocampal volume. Data from 124 patients were included in the final analysis based on the intention-to-treat principle. Both yoga and aerobic exercise groups demonstrated significant improvements in working memory (Pyoga group showed additional benefits in verbal acquisition (Pyoga having a larger effect on verbal acquisition and attention than aerobic exercise. The application of yoga and aerobic exercise as adjunctive treatments for early psychosis merits serious consideration. This study was supported by the Small Research Funding of the University of Hong Kong (201007176229), and RGC funding (C00240/762412) by the Authority of Research, Hong Kong.

  15. Serum Leptin Measured in Early Pregnancy Is Higher in Women With Preeclampsia Compared With Normotensive Pregnant Women

    DEFF Research Database (Denmark)

    Taylor, Brandie; Ness, Roberta B; Olsen, Jørn

    2015-01-01

    between serum leptin (measured: 9-26 weeks gestation) and preeclampsia among 430 primiparous preeclamptic women and 316 primiparous normotensive controls from the Danish National Birth Cohort. Median (interquartile range) leptin concentrations were calculated. Associations between leptin and preeclampsia...... (blood pressure ≥140/90 mm Hg), term preeclampsia (preeclampsia and delivery ≥37 weeks gestation), or preterm preeclampsia (preeclampsia and delivery smoking......, and socio-occupational status. As leptin is increased in obese women and the risk of preeclampsia increases with body mass index, we used the Sobel test to examine whether leptin is a mediator of this relationship. After adjustments, leptin concentrations were significantly higher in women with preeclampsia...

  16. Varus thrust in women with early medial knee osteoarthritis and its relation with the external knee adduction moment.

    Science.gov (United States)

    Mahmoudian, Armaghan; van Dieen, Jaap H; Bruijn, Sjoerd M; Baert, Isabel Ac; Faber, Gert S; Luyten, Frank P; Verschueren, Sabine Mp

    2016-11-01

    Varus thrust, defined as an abrupt increase of the knee varus angle during weight-bearing in gait, has been shown to be present in patients with moderate to severe knee osteoarthritis and is considered to be one of the risk factors for progression of symptomatic medial knee osteoarthritis. We evaluated the presence and magnitude of varus thrust and its relation with the Knee Adduction Moment in women with early medial knee osteoarthritis, and compared it to that in a group of controls and in a group of subjects with established medial knee osteoarthritis. Twenty-seven women with early medial knee osteoarthritis, 20 women with established medial knee osteoarthritis and 24 asymptomatic controls were evaluated. Varus thrust was estimated as an increase of the knee varus angle during the weight-bearing phase of gait at self-selected speed, assessed by 3D motion analysis. Varus thrust was significantly higher in both early and established osteoarthritis groups compared to the control group (Pthrust was significantly correlated with the second peak knee adduction moment. Higher varus thrust was found both in early and established stages of knee osteoarthritis, suggesting that problems with dynamic stabilization of the knee are present early in the development of knee osteoarthritis. This highlights the necessity of considering dynamic alignment in rehabilitation already in the early stages of the disease. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Promoting early presentation of breast cancer in older women: implementing an evidence-based intervention in routine clinical practice.

    Science.gov (United States)

    Forbes, Lindsay J L; Forster, Alice S; Dodd, Rachael H; Tucker, Lorraine; Laming, Rachel; Sellars, Sarah; Patnick, Julietta; Ramirez, Amanda J

    2012-01-01

    Background. Women over 70 with breast cancer have poorer one-year survival and present at a more advanced stage than younger women. Promoting early symptomatic presentation in older women may reduce stage cost effectively and is unlikely to lead to overdiagnosis. After examining efficacy in a randomised controlled trial, we piloted a brief health professional-delivered intervention to equip women to present promptly with breast symptoms, as an integral part of the final invited mammogram at age ~70, in the English National Health Service Breast Screening Programme. Methods. We trained mammographers, who then offered the intervention to older women in four breast screening services. We examined breast cancer awareness at baseline and one month in women receiving the intervention, and also in a service where the intervention was not offered. Results. We trained 27 mammographers to deliver the intervention confidently to a high standard. Breast cancer awareness increased 7-fold at one month in women receiving the intervention compared with 2-fold in the comparison service (odds ratio 15.2, 95% confidence interval 10.0 to 23.2). Conclusions. The PEP Intervention can be implemented in routine clinical practice with a potency similar to that achieved in a randomised controlled trial. It has the potential to reduce delay in diagnosis for breast cancer in older women.

  18. Promoting Early Presentation of Breast Cancer in Older Women: Implementing an Evidence-Based Intervention in Routine Clinical Practice

    Science.gov (United States)

    Forbes, Lindsay J. L.; Forster, Alice S.; Dodd, Rachael H.; Tucker, Lorraine; Laming, Rachel; Sellars, Sarah; Patnick, Julietta; Ramirez, Amanda J.

    2012-01-01

    Background. Women over 70 with breast cancer have poorer one-year survival and present at a more advanced stage than younger women. Promoting early symptomatic presentation in older women may reduce stage cost effectively and is unlikely to lead to overdiagnosis. After examining efficacy in a randomised controlled trial, we piloted a brief health professional-delivered intervention to equip women to present promptly with breast symptoms, as an integral part of the final invited mammogram at age ~70, in the English National Health Service Breast Screening Programme. Methods. We trained mammographers, who then offered the intervention to older women in four breast screening services. We examined breast cancer awareness at baseline and one month in women receiving the intervention, and also in a service where the intervention was not offered. Results. We trained 27 mammographers to deliver the intervention confidently to a high standard. Breast cancer awareness increased 7-fold at one month in women receiving the intervention compared with 2-fold in the comparison service (odds ratio 15.2, 95% confidence interval 10.0 to 23.2). Conclusions. The PEP Intervention can be implemented in routine clinical practice with a potency similar to that achieved in a randomised controlled trial. It has the potential to reduce delay in diagnosis for breast cancer in older women. PMID:23213334

  19. Promoting Early Presentation of Breast Cancer in Older Women: Implementing an Evidence-Based Intervention in Routine Clinical Practice

    Directory of Open Access Journals (Sweden)

    Lindsay J. L. Forbes

    2012-01-01

    Full Text Available Background. Women over 70 with breast cancer have poorer one-year survival and present at a more advanced stage than younger women. Promoting early symptomatic presentation in older women may reduce stage cost effectively and is unlikely to lead to overdiagnosis. After examining efficacy in a randomised controlled trial, we piloted a brief health professional-delivered intervention to equip women to present promptly with breast symptoms, as an integral part of the final invited mammogram at age ~70, in the English National Health Service Breast Screening Programme. Methods. We trained mammographers, who then offered the intervention to older women in four breast screening services. We examined breast cancer awareness at baseline and one month in women receiving the intervention, and also in a service where the intervention was not offered. Results. We trained 27 mammographers to deliver the intervention confidently to a high standard. Breast cancer awareness increased 7-fold at one month in women receiving the intervention compared with 2-fold in the comparison service (odds ratio 15.2, 95% confidence interval 10.0 to 23.2. Conclusions. The PEP Intervention can be implemented in routine clinical practice with a potency similar to that achieved in a randomised controlled trial. It has the potential to reduce delay in diagnosis for breast cancer in older women.

  20. T-HELPER 1 CYTOKINES INCREASE DURING EARLY PREGNANCY IN WOMEN WITH A HISTORY OF RECURRENT SPONTANEOUS ABORTION

    Directory of Open Access Journals (Sweden)

    A. Rezaei A. Dabbagh

    2000-08-01

    Full Text Available The measurment of various cytokines may provide a different tool for evaluation of the immune system. Recent investigations have shown that the number and function of peripheral natural killer cells (NK- cells increase during early pregnancy in women with a history of unexplained recurrent spontaneous abortions (RSA. NK-cells activity may be responsible for some cases of RSA. The objective of this study was to assess the role of the Thl cytokines (IL-2, IFN-y, TNF-a ; TNF-/0 in this phenomenon, and detection of Thl cytokines in women with RSA. The control group consisted of 40 women with no history of pregnancy loss and complication. The abortion group comprised of 92 women having at least 3 pregnancy losses. Blood from the control group and women with RSA was taken at the end of first trimester of gestational age and at the time of abortion, respectively. Sera were separated and peripheral blood lymphocytes were challenged with PHA using RPMI medium. All samples were tested for concentration of Thl cytokines using ELISA methods. It was considered that sera from women with RSA produced higher concentration of TNF-«, TNF-/? , and IL-2 in comparison with sera from normal pregnant women (NPW (P<0.001. We were not able to detect IL-2 in (NPW whereas in 31% sera from RSA group, IL-2 was detectable (P<0.001. However, there was no significant difference between IFN-y, concentration in sera from patients and control group (P<0.182. Tissue culture supernatant from women with RSA also produced higher concentration of TNF-a. IFN-y, TNF-/* and IL2, than control group. These data may explain the increase NK-cells cytotoxicity during early pregnancy in women with a history of RSA. It may also provide a diagnostic tool to predict the outcome of pregnancy.

  1. Risk factors for adverse fetal outcomes among women with early- versus late-onset intrahepatic cholestasis of pregnancy.

    Science.gov (United States)

    Jin, Jin; Pan, Shi-lei; Huang, Li-ping; Yu, Yan-hong; Zhong, Mei; Zhang, Guo-wei

    2015-03-01

    To determine risk factors for adverse fetal outcomes (AFOs) among women with intrahepatic cholestasis of pregnancy (ICP) on the basis of time of onset. In a retrospective analysis, data were obtained for all women with ICP admitted to two centers in Guangzhou, China, between February 1, 1993, and January 31, 2014. Patients were divided into group A (early-onset ICP) and group B (late-onset ICP), and were further divided on the basis of severity. The frequency of AFOs was assessed. Among 371 eligible women, 57 (15.4%) were in group A and 314 (84.6%) in group B. AFOs affected 20 (35.1%) women in group A and 67 (21.3%) in group B (P=0.024), and 12 (54.5%) of 22 women in group A and 21 (29.6%) of 71 in group B with severe ICP (P=0.032). Independent risk factors for AFO in group A were increased levels of serum bile acid (P=0.016) and alkaline phosphatase (P=0.004). Independent risk factors in group B were increased levels of alkaline phosphatase (P<0.001) and gamma-glutamyl transpeptidase (P=0.001). Early-onset ICP is associated with a higher frequency of AFO than is late-onset ICP, especially in severe disease. The risk factors differ between early-onset and late-onset ICP. Copyright © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  2. Why (suffering women matter for the heart of transformative missional theology perspectives on empowered women and mission in the New Testament and early Christianity

    Directory of Open Access Journals (Sweden)

    Jacobus (Kobus Kok

    2016-05-01

    Full Text Available In this article, it is argued that from the beginning of the Christ-following movement, the gospelmessage represented a challenge to a male-dominated social system. Early Christian literature shows that women, whose voices were often silenced in antiquity, are empowered. This is seen most clearly in the Martyrdom of Perpetua and Felicity. There we see how the protagonists is presented as acting counter culturally, challenging the world of men and turning patriarchal values and expectations upside down. It could be argued that the gospel message portrays women in the centre of missionary witness and empowers them in this manner. Furthermore, early Christian Martyrdom texts also show how the concept of suffering, honour and shame is redefined and how power and strength in weakness and oppression is reformulated.

  3. Isolation and Purification of an Early Pregnancy Factor–Like Molecule from Culture Supernatants Obtained from Lymphocytes of Pregnant Women

    OpenAIRE

    1998-01-01

    Purpose:Our purpose was to determine whether lymphocytes synthesize proteins during pregnancy, to observe whether one of the proteins synthesized has early pregnancy factor (EPF)–like activity and to isolate and purify this molecule from culture supernatants obtained from stimulated lymphocytes of pregnant women.

  4. Resisting Conformity: Anglican Mission Women and the Schooling of Girls in Early Nineteenth-Century West Africa

    Science.gov (United States)

    Leach, Fiona

    2012-01-01

    The origins of modern schooling in early nineteenth-century Africa have been poorly researched. Moreover, histories of education in Africa have focused largely on the education of boys. Little attention has been paid to girls' schooling or to the missionary women who sought to construct a new feminine Christian identity for African girls. In the…

  5. Self-Focused and Other-Focused Resiliency: Plausible Mechanisms Linking Early Family Adversity to Health Problems in College Women

    Science.gov (United States)

    Coleman, Sulamunn R. M.; Zawadzki, Matthew J.; Heron, Kristin E.; Vartanian, Lenny R.; Smyth, Joshua M.

    2016-01-01

    Objectives: This study examined whether self-focused and other-focused resiliency help explain how early family adversity relates to perceived stress, subjective health, and health behaviors in college women. Participants: Female students (N = 795) participated between October 2009 and May 2010. Methods: Participants completed self-report measures…

  6. Personality predicts perceived availability of social support and satisfaction with social support in women with early stage breast cancer

    NARCIS (Netherlands)

    B.L. den Oudsten; G.L. van Heck; A.F.W. van der Steeg; J.A. Roukema; J. de Vries

    2010-01-01

    This study examines the relationships between personality, on the one hand, and perceived availability of social support (PASS) and satisfaction with received social support (SRSS), on the other hand, in women with early stage breast cancer (BC). In addition, this study examined whether a stressful

  7. Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.

    LENUS (Irish Health Repository)

    Cleary, Brian J

    2012-02-01

    PURPOSE: To examine the extent, nature and determinants of medication use in early pregnancy. METHODS: We reviewed early pregnancy medication use, as reported to a midwife at the booking interview, in women delivering between 2000 and 2007 in a large maternity hospital in Dublin, Ireland (n = 61 252). RESULTS: Excluding folic acid, at least one medication was reported in 23 989 (39.2%) pregnancies. Over the counter (OTC) medications were reported in 11 970 (19.5%) pregnancies, illicit drugs or methadone in 545 (0.9%) and herbal medicines\\/supplements in 352 (0.58%). FDA category D and X medications were reported by 1532 (2.5%) and 1987 (3.2%) women. Asthma, depression and hypertension were among the most commonly reported chronic medical disorders. Medications with potential for foetal harm were reported by 86 (15.7%) women treated for depression and 68 (20%) women treated for hypertension. Factors associated with reporting the use of medications with potential for foetal harm included unplanned pregnancy (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 1.12-1.52), booking at less than 12 weeks gestation (aOR 1.83, 95%CI 1.58-2.13), being above 25 years of age, unemployed (aOR 2.58, 95%CI 2.03-3.29), nulliparous (aOR 1.41; 95%CI 1.22-1.63), single (aOR 1.28; 95%CI 1.06-1.54) or smoking during pregnancy (aOR 1.96, 95%CI 1.67-2.28). CONCLUSIONS: Women frequently report medication use in early pregnancy. Women and prescribers need to be aware of the lack of pregnancy safety data for many medications, and the need for pre-pregnancy planning. Prescribers should ensure that optimal medications are used when treating women of childbearing potential with chronic medical disorders.

  8. Patient satisfaction and barriers to initiating real-time continuous glucose monitoring in early pregnancy in women with diabetes

    DEFF Research Database (Denmark)

    Secher, A L; Madsen, A B; Nielsen, Lene Ringholm;

    2012-01-01

    for 6 days at median 9 (range 6-14) gestational weeks and were asked to answer a semi-structured questionnaire on patient satisfaction. Results: Median HbA(1c) was 49 (range 34-86) mmol/mol) [6.6 (5.3-10.0) %] and duration of diabetes was 12 (0.5-37) years. Continuous glucose monitoring was used for 6......Aim: To evaluate self-reported satisfaction and barriers to initiating real-time continuous glucose monitoring in early pregnancy among women with pregestational diabetes. Methods: Fifty-four women with Type 1 diabetes and 14 women with Type 2 diabetes were offered continuous glucose monitoring...... monitoring during daytime and twelve (18%) during sleep. Many women reported improved diabetes understanding (52%) and would recommend continuous glucose monitoring to others (83%). Twenty-four patients (36%) had continuous glucose monitoring removed earlier than planned (before the intended 6 days...

  9. Associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy: The generation r study

    NARCIS (Netherlands)

    G. Bai (Guannan); I.J. Korfage (Ida); E.H.D. Hafkamp-De Groen (Esther); V.W.V. Jaddoe (Vincent); Mautner, E. (Eva); H. Raat (Hein)

    2016-01-01

    textabstractThe objective of this study was to evaluate the independent associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy in the Generation R study, which is a prospective mother and child cohort. Analyses were based on 5079 women in early

  10. Early life factors associated with adult onset systemic lupus erythematosus (SLE in women

    Directory of Open Access Journals (Sweden)

    Christine Gibson Parks

    2016-03-01

    Full Text Available Background: Exposure early in life can influence adult disease and immunity, but the role of early life exposures in risk of SLE is not established.Methods: Women in a national cohort (ages 35-74 provided data on perinatal, maternal and sociodemographic factors, longest residence to age 14 and residential farm history of at least 12 months to age 18. Cases (N=124 reported SLE diagnosed age 16 years or older with use of disease modifying anti-rheumatic drugs. Non-cases (N=50,465 did not report lupus. Odds ratios (OR and 95% confidence intervals (CI were estimated by logistic regression adjusting for age and race/ethnicity. Results: SLE was associated with low birthweight (data on 84 cases and 36,477 non-cases; 4 weeks early vs. full-term; OR=3.4; 95%CI 1.6, 7.4. Considering longest childhood residence to age 14, SLE was associated with more frequent pesticide use (e.g., at least monthly OR=2.3; 95%CI 1.3, 4.1. SLE was associated with having an early and extended childhood farm residence (i.e., prenatal/maternal farm exposure and longest childhood farm residence; OR=1.8; 95%CI 1.1, 3.0 versus neither. In those with a childhood-only farm residence of 12+ months, agricultural pesticide use was associated with SLE, with the strongest associations for direct personal exposures. Conclusions: The association of SLE with premature birth is consistent with studies in other populations, and with an observed association with low birthweight. The associations of SLE with childhood exposure to residential and agricultural pesticides warrant further study.INTRODUCTIONSystemic lupus erythematosus (SLE is an autoimmune disease characterized by immune reactivity to multiple nuclear components and inflammation, resulting in diverse clinical features and multiple organ involvement. The causes of SLE are generally not known. Racial disparities and increased familial risk suggest a genetic predisposition. It is believed that environmental factors may contribute to

  11. The Breast and Cervical Cancer Early Detection Program, Medicaid, and breast cancer outcomes among Ohio's underserved women.

    Science.gov (United States)

    Koroukian, Siran M; Bakaki, Paul M; Htoo, Phyo Than; Han, Xiaozhen; Schluchter, Mark; Owusu, Cynthia; Cooper, Gregory S; Rose, Johnie; Flocke, Susan A

    2017-08-15

    As an organized screening program, the national Breast and Cervical Cancer Early Detection Program (BCCEDP) was launched in the early 1990s to improve breast cancer outcomes among underserved women. To analyze the impact of the BCCEDP on breast cancer outcomes in Ohio, this study compared cancer stages and mortality across BCCEDP participants, Medicaid beneficiaries, and "all others." This study linked data across the Ohio Cancer Incidence Surveillance System, Medicaid, the BCCEDP database, death certificates, and the US Census and identified 26,426 women aged 40 to 64 years who had been diagnosed with incident invasive breast cancer during the years 2002-2008 (deaths through 2010). The study groups were as follows: BCCEDP participants (1-time or repeat users), Medicaid beneficiaries (women enrolled in Medicaid before their cancer diagnosis [Medicaid/prediagnosis] or around the time of their cancer diagnosis [Medicaid/peridiagnosis]), and all others (women identified as neither BCCEDP participants nor Medicaid beneficiaries). The outcomes included advanced-stage cancer at diagnosis and mortality. A multivariable logistic and survival analysis was conducted to examine the independent association between the BCCEDP and Medicaid status and the outcomes. The percentage of women presenting with advanced-stage disease was highest among women in the Medicaid/peridiagnosis group (63.4%) and lowest among BCCEDP repeat users (38.6%). With adjustments for potential confounders and even in comparison with Medicaid/prediagnosis beneficiaries, those in the Medicaid/peridiagnosis group were twice as likely to be diagnosed with advanced-stage disease (adjusted odds ratio, 2.20; 95% confidence interval, 1.83-2.66). Medicaid/peridiagnosis women are at particularly high risk to be diagnosed with advanced-stage disease. Efforts to reduce breast cancer disparities must target this group of women before they present to Medicaid. Cancer 2017;123:3097-106. © 2017 American Cancer Society

  12. Relationship between equol producer status and metabolic parameters in 743 Japanese women: equol producer status is associated with antiatherosclerotic conditions in women around menopause and early postmenopause.

    Science.gov (United States)

    Yoshikata, Remi; Myint, Khin Z; Ohta, Hiroaki

    2017-02-01

    Equol, an active metabolite possessing estrogen-like activity, is produced by the action of intestinal flora on soy isoflavones. There is an increasing evidence regarding its efficacy in the relief of menopausal symptoms, suppression of decreased bone mineral density, and lipid profile improvement. Only those with equol-producing capacity, however, seem to benefit. Thus, we examined the relationship between equol producer status and parameters associated with lifestyle-related diseases in women from their 20s to 80s. This cross-sectional study was conducted among 743 women (21-89 y; average age: 52.5 ± 11.8 y) who have undergone health screening at Tokyo Midtown Medical Center and given consent to participate in the study. The relationship between equol producer status and metabolic parameters was assessed. In our study, 236 women (32%) were equol producers. Equol producers had significantly lower triglycerides and higher high-density lipoprotein cholesterol levels compared with nonproducers. Equol-producing women in their 50s showed significantly lower body fat level, visceral fat area, triglyceride levels, pulse wave velocity, uric acid levels, and high sensitivity C-reactive protein levels. In addition, women in their 60s showed significantly higher levels of high-density lipoprotein cholesterol. In multivariate logistic regression, for women in their 50s, equol production was significantly associated with lower arterial stiffness and uric acid levels, and a high ratio of eicosapentaenoic acid to arachidonic acid, whereas it was significantly associated with lower urinary N-telopeptides in their 60s. Equol producer status was associated with favorable metabolic parameters, in women in the early phase postmenopause, with the transitional periods noted with declining intrinsic estrogen levels.

  13. Anterior Abdominal Wall Leiomyoma Arising De Novo in a Perimenopausal Woman

    Directory of Open Access Journals (Sweden)

    Hamed A. Al-Wadaani

    2012-07-01

    Full Text Available Extrauterine or extraintestinal leiomyomas are extremely uncommon especially in the pre-peritoneal area or within the anterior abdominal wall muscles. These tumors have been ascribed to intraoperative seeding during resection of a fibroid or a leiomyoma of gut, to exogenous hormone replacement therapy or a major derangement of glucose and/or lipid metabolism. So far, there is no published report of de novo origin of anterior abdominal wall pure leiomyoma in the literature. The author herein reports a case of perimenopausal multiparous woman without any listing of previous gynecological surgery or hormone therapy who presented with a large pre-peritoneal intramuscular leiomyoma of the anterior abdominal wall. The patient underwent complete primary resection with amelioration of her symptoms.

  14. 围绝经期宫颈病变所致阴道流血%Perimenopausal abnormal vaginal bleeding caused by cervical lesions

    Institute of Scientific and Technical Information of China (English)

    王登凤; 张国楠

    2012-01-01

    围绝经期妇女中,不规则阴道流血是一个最常见、也是最易被忽视的症状,宫颈病变是其主要原因之一,主要包括了宫颈炎、宫颈炎症相关疾病、宫颈上皮内瘤变、宫颈癌、宫颈肌瘤、宫颈结核、宫颈妊娠等,可以通过妇科查体、宫颈脱落细胞学检查、宫颈活检等简单手段在短时间内得到确诊.%For perimenopausal women, abnormal vaginal bleeding is the most common symptom, which is also the most neglected one. In various causes, cervical lesion is the one which can be diagnosed by some simple methods, e. g. gynecological examination , cervical cytology, and cervical biopsy. Cervical lesions in this review include: cervicitis, cervicitis related disease, cervical intraepithelial neoplasia, cervical cancer, cervical myoma, tuberculosis of cervix, cervical pregnancy, etc.

  15. [Cardiovascular risks differences in women: how can we improve the management?].

    Science.gov (United States)

    Mounier-Vehier, Claire; Delsart, Pascal; Letombe, Brigitte

    2010-02-01

    Some aspects of cardiovascular risk differ in women; on the whole, this risk is underestimated and insufficiently treated because of lack of knowledge of the problem. According to an INSERM report in 1999, one Frenchwoman in three will die from a cardiovascular disease, while only one in 25 will die of breast cancer. For new generations of women, the protective effect of the estrogen burden may be counterbalanced by the increasing prevalence during the perimenopausal period of metabolic syndrome, particularly harmful in terms of cardiovascular risk. Before oral contraceptives are prescribed, an extremely thorough history must be taken. These should in no case be prescribed for smokers older than 35 years, regardless of how little they smoke. Neither uncomplicated diabetes nor controlled dyslipidemia is a contraindication to hormonal contraception for women. It now seems clear that hormone therapy of menopause does not prevent cardiovascular disease. Nor, however, does it increase the risk if it is administered early, that is, during the first five years of menopause, and accompanied by close monitoring of cardiovascular risk factors and annual reassessment of the benefit-risk balance. The old cliché remains true: the patient at high risk of cardiovascular disease is a man older than 50 years, who smokes and is obese. But men still die more often from cancer than from cardiovascular disease, while the latter is the leading of cause in women, especially after menopause. The symptoms are often misleading and diagnosis is thus frequently delayed. Smoking, lack of exercise, overweight, and stress are all risk factors in women of all ages, and exposure to them can increase as women grow older. These factors should alert the physician and induce earlier screening for cardiovascular disease. In practice, too many women and their physicians underestimate their real risk of cardiovascular accident. It is accordingly essential to develop new campaigns of information and

  16. Observation on cognitive therapy combined with massage in treatment for symptoms of perimenopause%认知疗法与改良抚触治疗围绝经期症状的观察

    Institute of Scientific and Technical Information of China (English)

    刘伟红; 刘福凤; 高海妮

    2014-01-01

    Objective To investigate the clinical effect of the cognitive therapy combined with massage on the treatment for perimenopause women.Methods 83 women with perimenpausal syndrome were randomly divided into two groups,control group (n=41) was given Chinese medicine,the observation group (n=42) was given cognitive therapy combined with improved modified massage based on the control group.Results The total effective rate was 78% in control group,88.09% in observation group.Conclusion Cognitive therapy combined with modified massage can effectively cure perimenopause sydrome,and improve the quality of life of patients.%目的 探讨认知疗法联合抚触治疗围绝经期的临床效果.方法 将83例围绝经期综合征患者随机分成两组.对照组41例给予中药口服,观察组42例在对照组的基础上给予认知疗法联合改良抚触进行治疗.结果 对照组总有效率为78%,观察组总有效率为88.09%.结论 认知疗法联合改良抚触治疗围绝经期综合症有较好的疗效,达到提高患者生活质量的目的.

  17. Quality of Life in Menopausal Women: A Brazilian Portuguese Version of the Cervantes Scale

    Directory of Open Access Journals (Sweden)

    José E. M. Lima

    2012-01-01

    Full Text Available We present the translation, cultural adaptation and validation of the Cervantes Scale to Brazilian Portuguese. The Cervantes Scale (CS was originally described in Spanish, and is a tool to measure health-related quality of life in perimenopausal and menopausal women. A cross-sectional study was carried out with 180 women aged 45 to 64 years. In addition to the CS, the following questionnaires were applied: Women's Health Questionnaire (WHQ and abbreviated version of the World Health Organization’s Quality of Life Questionnaire (Abbreviated WHOQOL-bref. In conclusion, the Brazilian Portuguese version of the CS is easy to apply and understand. The evaluation of its psychometric properties was satisfactory, and it can be applied to assess health-related QoL in Brazilian perimenopausal and menopausal women.

  18. Quality of life, anxiety and depression symptoms in early and late pregnancy in women with pregestational diabetes.

    Science.gov (United States)

    Do, Nicoline C; Secher, Anna L; Cramon, Per; Ringholm, Lene; Watt, Torquil; Damm, Peter; Mathiesen, Elisabeth R

    2017-02-01

    The aim of this study was to explore changes in health-related quality of life, anxiety and depression symptoms during pregnancy in women with pregestational diabetes. An observational cohort study including 137 pregnant women with pregestational diabetes (110 with type 1 and 27 with type 2). To evaluate changes from early to late pregnancy, the internationally validated questionnaires 36-Item Short-Form Health Survey (SF-36) and Hospital Anxiety and Depression Scale (HADS) were completed at 8 and 33 gestational weeks. From early to late pregnancy, the SF-36 scales Physical Function, Role Physical, Bodily Pain and Physical Component Summary worsened (p anxiety score improved slightly from 5.0 (3.3) to 4.5 (3.4) (p = 0.04) whereas the HADS depression score remained unchanged. The prevalence of women with HADS anxiety or depression score ≥8 did not change. Physical quality of life deteriorated whereas mental quality of life improved slightly during pregnancy in women with pregestational diabetes. A minor reduction in anxiety and stable depression symptoms was observed. The results on mental health are reassuring, considering the great demands that pregnancy places on women with pregestational diabetes. © 2016 Nordic Federation of Societies of Obstetrics and Gynecology.

  19. Women'S issues and epilepsy.

    Science.gov (United States)

    Noe, Katherine H; Pack, Alison M

    2010-06-01

    Women with epilepsy (WWE) may experience changes in seizure control related to alterations in neuronal excitability mediated by estrogen and progesterone. A third or more of women will reliably note seizures that are linked to menstruation or ovulation. Reproductive hormone-related exacerbation of seizure control is also observed during perimenopause. Seizures and antiepileptic drugs (AEDs) also can adversely affect reproductive health. WWE have higher than expected rates of menstrual disorders and infertility. Enzyme-inducing AEDs interact with hormonal contraceptives, potentially limiting options for birth control. Exposure to AEDs during pregnancy increases the risk of congenital malformations and cognitive impairments in children born to WWE. Chronic AED use increases the risk of vitamin D deficiency, decreased bone quality and density, and fractures. These concerns heighten the need to taper AEDs when appropriate and to manage WWE on the simplest AED regimen that will maintain seizure freedom.

  20. Cytokine RNA levels in transiliac bone biopsies from healthy early postmenopausal women

    DEFF Research Database (Denmark)

    Abrahamsen, Bo; Shalhoub, V; Larson, E K

    2000-01-01

    The cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and IL-6 induce osteoclast formation and may contribute to the development of postmenopausal osteoporosis. Cross-sectional studies have suggested that both IL-1 and IL-1ra secretion increase on estrogen withdrawa...... for IL-6 mRNA. The findings support the hypothesis that IL-1beta production within bone increases with declining estrogen levels, and that an increase in II-1ra protects against accelerated bone loss.......The cytokines interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and IL-6 induce osteoclast formation and may contribute to the development of postmenopausal osteoporosis. Cross-sectional studies have suggested that both IL-1 and IL-1ra secretion increase on estrogen withdrawal......, and that postmenopausal osteoporosis is associated with an inadequate increase in monocyte IL-1ra secretion with age. We measured cytokine mRNA (IL-1beta, IL-1ra, IL-6, and TNF-alpha) directly in bone biopsies from early postmenopausal women to determine if a lower compensatory increase in IL-1ra mRNA could...

  1. Expression of BAFF in the trophoblast and decidua of normal early pregnant women and patients with recurrent spontaneous miscarriage

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Background BAFF,the B cell activation factor,is a member of the tumor necrosis factor(TNF)ligand family that binds to BCMA,TACI,and BAFF-R.Previous studies have shown that members of the TNF family are detected in human placental trophoblast cells,but the expression patterns of BAFF involved in human decidua and the differential expression of BAFF between normal pregnancy and miscarriage are still incompletely documented or unknown.This study was designed to investigate the expression of BAFF and BAFF-R in the trophoblast and decidua of normal early pregnant women and recurrent spontaneous abortion(RSA)patients.Methods Forty-five patients with RSA and 45 normal pregnant women were included in this study.By reverse transcriptase-polymerase chain reaction(RT-PCR),Western blotting and immunohistochemical experiments,we explored the expression of BAFF and BAFF-R in the maternal-fetal interface of normal early pregnant women and RSA patients.Results Analysis by RT-PCR and Western blotting revealed that BAFF was detected in both trophoblast and decidua of all the samples,and the expression level was higher in the tissues of normal early pregnant women(P<0.05)than that of recurrent spontaneous abortion patients under the same gestational weeks.Messages for BAFF-R were absent.Immunohistochemical experiments showed that expression of BAFF was cell-specific which was localized to villous cytotrophoblast and syncytiotrophoblast cells in trophoblast and to stromal cells in decidua.Whereas BAFF was prominent on the trophoblast and decidua of normal early pregnant women,it was decreased in the tissues of RSA patients.Conclusions BAFF might steer maternal leukocytes away from a harmful immune response and toward a favorable one and play a potentially vital role for successful pregnancy.

  2. Out-of-pocket costs in the year after early breast cancer among Canadian women and spouses.

    Science.gov (United States)

    Lauzier, Sophie; Lévesque, Pascale; Mondor, Myrto; Drolet, Mélanie; Coyle, Douglas; Brisson, Jacques; Mâsse, Benoît; Provencher, Louise; Robidoux, André; Maunsell, Elizabeth

    2013-02-20

    We lack comprehensive information about the extent of out-of-pocket costs after diagnosis of early breast cancer and their effects on the family's financial situation. This longitudinal study assessed out-of-pocket costs and wage losses during the first year after diagnosis of early breast cancer among Canadian women and spouses. Out-of-pocket costs for treatments and follow-up, consultations with other practitioners, home help, clothing, and natural health products were estimated, with information collected from telephone interviews. Generalized linear models were used to identify women at risk of having higher costs and the effects of out-of-pocket costs on perceptions of the family's financial situation. Overall, 829 women (participation, 86.2%) and 391 spouses participated. Women's median net out-of-pocket costs during the year after diagnosis were $1002 (2003 Canadian dollars; mean = $1365; SD = $1238), and 74.4% of these costs resulted from treatments and follow-up. Spouses' median costs were $111 (mean = $234; SD = $320), or 9% of couples' total expenses. In multivariable analyses, the percentage of women with out-of-pocket costs of $1773 or more (upper quartile) was statistically significantly associated with higher education, working at diagnosis, living more than 50 km from the hospital where surgery was performed, and having two and three different types of adjuvant treatment (all 2-sided P values ≤ .01). However, when considered simultaneously with wage losses, out-of-pocket costs were not associated with perceived deterioration in the family's financial situation; rather, wage losses were the driving factor. Overall, out-of-pocket costs from breast cancer for the year after diagnosis are probably not unmanageable for most women. However, some women were at higher risk of experiencing financial burden resulting from these costs.

  3. Stress at the place of work and cognitive functions among women performing intellectual work during peri- and post-menopausal period.

    Science.gov (United States)

    Gujski, Mariusz; Pinkas, Jarosław; Juńczyk, Tomasz; Pawełczak-Barszczowska, Adrianna; Raczkiewicz, Dorota; Owoc, Alfred; Bojar, Iwona

    2017-10-06

    The analysis of the relationship between stress at work and results of cognitive functions amongst women, at peri- and post-menopausal age, performing intellectual work. The study group included women, aged 45-66 years old, employed as intellectual workers. Research instruments were: the Montreal Cognitive Assessment; computer tests of the CNS Vital Signs; the Subjective Work Characteristics Questionnaire, and a questionnaire designed by the author. The results were statistically analyzed. Nearly a half of respondents experienced high stress at the place of work; 1/3 - on the average level, on a low level - every fifth. The largest number of respondents experienced stress caused by social contacts. Among a half of the women, stress was caused by the lack of awards at work, followed by the lack of support. Slightly fewer of them experienced stress caused by the feeling of psychological load related to the complexity of work or the feeling of uncertainty caused by the organization of work. Every third woman experienced stress due to the sense of responsibility or the lack of control. The smallest number experienced stress caused by physical arduousness, the sense of threat and unpleasant working conditions. The examined women obtained the best results with respect to simple attention, the worst results - with respect to the reaction time. The results concerning the remaining 9 cognitive functions were ranked in the middle of the aforementioned results. The intensity of stress at work and factors which caused this stress, negatively correlated with simple attention of women in the early peri-menopausal period, while positively correlating with the psychomotor and processing speed of women in the late peri-menopausal period. Among the post-menopausal women, negative correlations were observed between the majority of cognitive functions and the intensity of stress at work, and the majority of factors which caused this stress. Cognitive functions of the examined women

  4. Efficacy and acceptability of a mifepristone-misoprostol combined regimen for early induced abortion among women in Mexico City.

    Science.gov (United States)

    Peña, Melanie; Dzuba, Ilana G; Smith, Patricio Sanhueza; Mendoza, Luis Jorge Arellano; Bousiéguez, Manuel; Martínez, María Laura García; Polanco, Ranulfo Ríos; Villalón, Antonio Eduardo Flores; Winikoff, Beverly

    2014-10-01

    To evaluate the experience of women receiving mifepristone-misoprostol for early induced abortion in public sector facilities in the Federal District of Mexico City. An open-label prospective study was conducted with 1000 pregnant women who sought induced abortion with a pregnancy of up to 63days of gestation, as measured from the date of their last menstrual period. The study was conducted in three public sector healthcare facilities: two secondary level hospitals and one primary care clinic. Women ingested 200mg mifepristone on day 1, followed by 800μg buccal misoprostol 24hours later, and they returned for follow-up on day 8. The primary outcome was complete abortion without recourse to surgical intervention. A total of 971 women received mifepristone-misoprostol and were included in the analysis for efficacy of treatment. The overall efficacy of the combined medical abortion regimen studied was 97.3% (n=945); the success rate did not vary significantly by gestational age (95.9%-100%; P=0.449). Most women (n=922, 95.0%) had a successful induced abortion with only one dose of misoprostol. The combined mifepristone and buccal misoprostol regimen was found to be highly effective and acceptable among Mexican women. www.ClinicalTrials.gov: NCT00386282. Copyright © 2014 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  5. A retrospective analysis of dermatoses in the perimenopausal population attending a tertiary care centre in South India

    Directory of Open Access Journals (Sweden)

    Shamma Aboobacker

    2015-01-01

    Conclusion: The leading dermatoses being eczema and urticaria in the perimenopausal population probably accounts for a tendency of exaggerated response to external factors. The population studied in the current study might be of significance due to complete lack of treatment in the form of hormone replacement therapy (HRT, while routine sun exposure and cultural practices predominate. However, evaluation with respect to individual factors is beyond the scope of the current study and may be necessary to define a causal relationship.

  6. Early cessation of breastfeeding amongst women in South Africa: an area needing urgent attention to improve child health

    Directory of Open Access Journals (Sweden)

    Doherty Tanya

    2012-07-01

    Full Text Available Abstract Background Breastfeeding is a critical component of interventions to reduce child mortality. Exclusive breastfeeding practice is extremely low in South Africa and there has been no improvement in this over the past ten years largely due to fears of HIV transmission. Early cessation of breastfeeding has been found to have negative effects on child morbidity and survival in several studies in Africa. This paper reports on determinants of early breastfeeding cessation among women in South Africa. Methods This is a sub group analysis of a community-based cluster-randomized trial (PROMISE EBF promoting exclusive breastfeeding in three South African sites (Paarl in the Western Cape Province, and Umlazi and Rietvlei in KwaZulu-Natal between 2006 and 2008 (ClinicalTrials.gov no: NCT00397150. Infant feeding recall of 22 food and fluid items was collected at 3, 6, 12 and 24 weeks postpartum. Women’s experiences of breast health problems were also collected at the same time points. 999 women who ever breastfed were included in the analysis. Univariable and multivariable logistic regression analysis adjusting for site, arm and cluster, was performed to determine predictors of stopping breastfeeding by 12 weeks postpartum. Results By 12 weeks postpartum, 20% of HIV-negative women and 40% of HIV-positive women had stopped all breastfeeding. About a third of women introduced other fluids, most commonly formula milk, within the first 3 days after birth. Antenatal intention not to breastfeed and being undecided about how to feed were most strongly associated with stopping breastfeeding by 12 weeks (Adjusted odds ratio, AOR 5.6, 95% CI 3.4 – 9.5 and AOR 4.1, 95% CI 1.6 – 10.8, respectively. Also important was self-reported breast health problems associated with a 3-fold risk of stopping breastfeeding (AOR 3.1, 95%CI 1.7 – 5.7 and the mother having her own income doubled the risk of stopping breastfeeding (AOR 1.9, 95% CI 1.3 – 2

  7. The common single-nucleotide polymorphism rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women.

    Science.gov (United States)

    Wan, Ji-Peng; Wang, Hong; Li, Chang-Zhong; Zhao, Han; You, Li; Shi, Dong-Hong; Sun, Xiu-Hua; Lv, Hong; Wang, Fei; Wen, Ze-Qing; Wang, Xie-Tong; Chen, Zi-Jiang

    2014-11-01

    Preeclampsia, characterized by hypertension and proteinuria, remains a leading cause of maternal morbidity and mortality. Recently, a genome-wide association study (GWAS) identified the single-nucleotide polymorphism, rs2681472, as a new hypertension susceptibility genetic variant. The purpose of this study was to evaluate the association between preeclampsia and rs268172 in a Northern Han Chinese population. We genotyped 1218 unrelated Northern Han Chinese women, including 515 patients with preeclampsia and 703 healthy controls. No significant differences were detected in the allele frequencies between patients and controls (P = .23). When patients were divided into early-onset and late-onset preeclampsia according to gestational age of disease onset, the allele frequencies significantly differed between controls and patients with early-onset preeclampsia (P = .02). Genotype frequencies also were significantly different between controls and patients early-onset preeclampsia when data were analyzed under additive (P = .03) and dominant (P = .009) models. We replicated this association in an independent Northern Han Chinese population and observed a significant difference in the allele frequencies between patients with early-onset preeclampsia and controls (P = .011). We report that rs2681472 is associated with early-onset preeclampsia in Northern Han Chinese women. © The Author(s) 2014.

  8. 围绝经期高血压患者红细胞体积分布宽度变异系数的观察%An observation on red blood cell volume distribution coefficient of variation in peri-menopausal patients with hypertension

    Institute of Scientific and Technical Information of China (English)

    赵玉娟; 吴胜群; 李学文; 李贺; 何冰

    2012-01-01

    the grace classification of hypertension. The levels of hemoglobin (Hb), mean corpuscular volume (MCV) and RDW-CV were detected in peri-menopausal hypertension group and healthy control group, and the relationship between blood pressure and RDW-CV was analyzed. Logistic regression analysis was applied and the bias factors of MCV and Hb were calibrated ; afterwards the correlation between RDW-CV and peri-menopausal hypertension was analyzed. The changes of RDW-CV in hypertension grade 1 and 2 groups arm the healthy control group were observed. Results The levels of Hb (g/Lj and MCV (fl) were significantly lower (Hb ; 143.14+12.18 vs. 157.36nl3.31, MCV : 86.13.r5.13 vs. 91.31±6.51, both P<0.05)in peri-menopausal hypertension group than those in healthy control group , while RDW-CV was obviously higher [(14.13±1.08) % vs. (12.35±0.83)%, P<0.05] in the peri-menopausal hypertension than that in healthy control group. After correction of the bias factors of MCV and Hb, the result showed that RDW-CV had a positive correlation with peri-menopausal hypertension [ Hb ; odds ratio (OR) =0.618, MCV ; OR= 0.753, RDW-CV ; OR=0.761, all p<0.05]. Compared with healthy control group, all peri-menopausal patients with hypertension had a significant increase in RDW-CV, the range of RDW-CV elevation in hypertension grade 2 group being more significant [ (14.26±0.89) % vs. (12.35±0.82) %, P<0.05]. Conclusions RDW-CV independently correlates with peri-menopausal hypertension, therefore, RDW-CV can be a clinical monitoring indicator to provide an early information warning the peri-menopausal patients with hypertension the possible occurrence of cardiovascular and/or cerebrovas-cular crisis.

  9. P17 - Early Menopause Influences Osteopenic or Osteoporotic Status in Postmenopausal Women: Preliminary Results from the Prof Project

    Science.gov (United States)

    Piscitelli, P.; Rigliano, V.; Neglia, C.; Chitano, G.; Argentiero, A.; Paladini, D.; Mundi, S.; Paladini, L.; Greco, M.; Girasoli, C.; Gianicolo, M. E.; Pantile, V.; Argentiero, D.; De Padova, G.; Nibio, L.; Pansa, L.; Di Giuseppe, P.; Minosi, A.; Cirasino, L.; Laselva, G.; Scialpi, M.; D’Angela, D.; Benvenuto, M.; Brandi, M. L.; Distante, A.

    2010-01-01

    Aims: There is evidence that demographic trends in Southern Apulia are characterised by a huge proportion of elderly people relative to the general population, resulting in an ageing index which is higher than that recorded in other Southern Italian regions and/or sub-regions. Within the PROF (Prevention of Osteoporotic Fractures) project, which aims to foster synergistic efforts between researchers and clinicians, we investigated the correlation between early menopause and osteopenic or osteoporotic status in postmenopausal women by quantitative bone ultrasound evaluation (QUS). Methods: In a period of almost six years (2004–2010), 5665 postmenopausal women (mean age 55, ranging from 39 to 84) were screened by QUS at either the heel or the phalanx. Demographic and anamnestic data were recorded for all the patients, including BMI, nutrition, menopause, physical activity, previous fractures, familial fragility fractures. Three categories of demineralisation were identified: a) Demineralisation, when any T-score <−1.0 SD was observed; b) Severe demineralisation, whenever a T-score <−2.0 was observed, corresponding to a higher risk of fracture; c) Osteoporosis, whenever a T-score <−2.5±0.2 (for the heel) or T-score <−3.2±0.2 (for the phalanx) was observed. Descriptive statistical analyses were performed in order to assess the correlation between early menopause (<45 years of age) and the osteopenic or osteoporotic status of the patients. Results: Of the 5665 subjects examined overall, demineralisation was observed in 4487 subjects (79%), with severe osteopenia or osteoporotic status being documented in 2823 women (50%) and frank osteoporotic status in 846 (15%). In total, of 1169 women reporting an early menopause, 937 showed demineralisation corresponding to at least an osteopenic status (80%). In 605 of these patients (65%), there was a severe osteopenic or osteoporotic status, while 182 women experiencing an early menopause were found to be frankly

  10. Validation of a food frequency questionnaire for Japanese pregnant women with and without nausea and vomiting in early pregnancy.

    Science.gov (United States)

    Ogawa, Kohei; Jwa, Seung-Chik; Kobayashi, Minatsu; Morisaki, Naho; Sago, Haruhiko; Fujiwara, Takeo

    2017-05-01

    No previous study has shown the validity of a food frequency questionnaire (FFQ) in early pregnancy with consideration of nausea and vomiting during pregnancy (NVP). The aim of this study was to evaluate the validity of a FFQ in early pregnancy for Japanese pregnant women. We included 188 women before 15 weeks of gestation and compared estimated nutrient intake and food group intake based on a modified FFQ with that based on 3-day dietary records (DRs). Spearman's rank correlation coefficients, adjusting energy intake and attenuating within-person error, were calculated. Subgroup analysis for those with and without NVP was conducted. We also examined the degree of appropriate classification across categories between FFQ and DRs through division of consumption of nutrients and food groups into quintiles. Crude Spearman's correlation coefficients of nutrients ranged from 0.098 (sodium) to 0.401 (vitamin C), and all of the 36 nutrients were statistically significant. In 27 food groups, correlation coefficients ranged from -0.015 (alcohol) to 0.572 (yogurt), and 81% were statistically significant. In subgroup analysis, correlation coefficients in 89% of nutrients and 70% of food groups in women with NVP and 97% of nutrients and 74% of food groups in women without NVP were statistically significant. On average, 63.7% of nutrients and 60.4% of food groups were classified into same or adjacent quintiles according to the FFQ and DRs. The FFQ is a useful instrument, regardless of NVP, for assessing the diet of women in early pregnancy in Japan. Copyright © 2016 The Authors. Production and hosting by Elsevier B.V. All rights reserved.

  11. Validation of a food frequency questionnaire for Japanese pregnant women with and without nausea and vomiting in early pregnancy

    Directory of Open Access Journals (Sweden)

    Kohei Ogawa

    2017-05-01

    Full Text Available Background: No previous study has shown the validity of a food frequency questionnaire (FFQ in early pregnancy with consideration of nausea and vomiting during pregnancy (NVP. The aim of this study was to evaluate the validity of a FFQ in early pregnancy for Japanese pregnant women. Method: We included 188 women before 15 weeks of gestation and compared estimated nutrient intake and food group intake based on a modified FFQ with that based on 3-day dietary records (DRs. Spearman's rank correlation coefficients, adjusting energy intake and attenuating within-person error, were calculated. Subgroup analysis for those with and without NVP was conducted. We also examined the degree of appropriate classification across categories between FFQ and DRs through division of consumption of nutrients and food groups into quintiles. Results: Crude Spearman's correlation coefficients of nutrients ranged from 0.098 (sodium to 0.401 (vitamin C, and all of the 36 nutrients were statistically significant. In 27 food groups, correlation coefficients ranged from −0.015 (alcohol to 0.572 (yogurt, and 81% were statistically significant. In subgroup analysis, correlation coefficients in 89% of nutrients and 70% of food groups in women with NVP and 97% of nutrients and 74% of food groups in women without NVP were statistically significant. On average, 63.7% of nutrients and 60.4% of food groups were classified into same or adjacent quintiles according to the FFQ and DRs. Conclusions: The FFQ is a useful instrument, regardless of NVP, for assessing the diet of women in early pregnancy in Japan.

  12. Prenatal and early life stress and risk of eating disorders in adolescent girls and young women.

    Science.gov (United States)

    Su, Xiujuan; Liang, Hong; Yuan, Wei; Olsen, Jørn; Cnattingius, Sven; Li, Jiong

    2016-11-01

    Females are more likely than males to develop eating disorders (EDs) in the adolescence and youth, and the etiology remains unclear. We aimed to estimate the effect of severe early life stress following bereavement, the death of a close relative, on the risk of EDs among females aged 10-26 years. This population-based cohort study included girls born in Denmark (from 1973 to 2000) or Sweden (from 1970 to 1997). Girls were categorized as exposed if they were born to mothers who lost a close relative 1 year prior to or during pregnancy or if the girl herself lost a parent or a sibling within the first 10 years of life. All other girls were included in unexposed group. An ED case was defined by a diagnosis of EDs at ages of 10-26 years, including broadly defined bulimia nervosa, broadly defined anorexia nervosa and mixed EDs. Poisson regression models were used to estimate the incidence rate ratio (IRR) between exposed group and unexposed group.A total of 64453 (3.05 %) girls were included in the exposed group. We identified 9477 girls with a diagnosis of EDs, of whom 307 (3.24 %) were from the exposed group. Both prenatal and postnatal exposure following bereavement by unexpected death was associated with an increased overall risk of EDs (IRRprenatal: 1.49, 95 % CI: 1.01-2.19 and IRRpostnatal: 1.34, 95 % CI: 1.05-1.71). We observed similar results for subtypes of broadly defined bulimia nervosa (IRR: 2.47, 95 % CI: 1.67-3.65) and mixed EDs (IRR: 1.45, 95 % CI: 1.02-2.07).Our findings suggest that prenatal and early postnatal life stress due to unexpected death of a close relative is associated with an increased overall risk of eating disorders in adolescent girls and young women. The increased risk might be driven mainly by differences in broadly defined bulimia nervosa and mixed eating disorders, but not broadly defined anorexia nervosa.

  13. “Exchanging voices, questioning voices"… : dissention and dialogue in the poetry of early Victorian women

    OpenAIRE

    Guimarães, Paula Alexandra

    2009-01-01

    The purpose of this paper is to examine the extent to which early Victorian women poets (1820-1850) have communicated through their poetry their feelings of dissention in relation both to patriarchal conventions and the masculine poetic tradition. By creating their own myths and by adopting the multivocal forms of the dialogue with the other, the dramatic monologue and the soliloquy, these female poets have managed to question traditional concepts without directly exposing themselves. For rea...

  14. Early gestation screening of pregnant women for iodine deficiency disorders and iron deficiency in urban centre in Vadodara, Gujarat, India.

    Science.gov (United States)

    Joshi, K; Nair, S; Khade, C; Rajan, M G R

    2014-02-01

    Pregnancy is a special condition where many metabolic changes may occur because of increased requirement of essential micronutrients such as iron and iodine. Foetal thyroid starts producing its own thyroid hormones after 12 weeks of gestation. Therefore, the first trimester is very crucial for meeting thyroid hormone requirements of the mother and foetus. Iodine deficiency and iron deficiency may affect mental and physical growth of the foetus. Hence, it is very important to establish a programme on the screening of pregnant women for thyroid dysfunction tests along with established iron status assessment. Thus, the study was aimed to screen the pregnant women for iodine deficiency disorders and iron deficiency during early gestation, situational analysis on thyroid insufficiency and iron deficiency in pregnant women (gestational age iron deficiency was 91%. Screening programme for iodine deficiency during early gestation should be implemented along with the existing programme of haemoglobin estimation at first prenatal visit. This would help prevent damage to the developing brain and growth of the foetus and also to trace at-risk pregnant women.

  15. Health beliefs related to breast cancer screening behaviours in women who applied to cancer early detection center

    Directory of Open Access Journals (Sweden)

    Melek Serpil Talas

    2015-06-01

    Full Text Available Background: Breast cancer is one of the most common malignancies affecting women in Turkey. The early detection methods for breast cancer have been associated with health belief variables. Objectives: The purpose of this study was to determine women's health beliefs related to breast cancer screening behaviours. Methods: This study was designed as descriptive and cross-sectional survey and was performed on 344 women who applied the Nigde Cancer Early Diagnosis, Screening and Education Center between May and October 2009. The data were collected using a questionnaire which consists of socio-demographic characteristics and breast cancer risk factors and Health Belief Model Scale. Data analysis was performed using frequency and Mann-Whitney U Test. All values of p0.05. According to study results, the rate of regular BSE performance rate for women was found low. Therefore, KETEM was planned to the training programs related to breast cancer screening methods. [TAF Prev Med Bull 2015; 14(3.000: 265-271

  16. Early uptake of HIV counselling and testing among pregnant women at different levels of health facilities – experiences from a community-based study in Northern Vietnam

    DEFF Research Database (Denmark)

    Nguyen Thi Thuy, Hanh; Gammeltoft, Tine; Rasch, Vibeke

    2011-01-01

    ABSTRACT: BACKGROUND: HIV counselling and testing for pregnant women is a key factor for successful prevention of mother to child transmission of HIV. Women's access to testing can be improved by scaling up the distribution of this service at all levels of health facilities. However, this strategy...... will only be effective if pregnant women are tested early and provided enough counselling. OBJECTIVE: To assess early uptake of HIV testing and the provision of HIV counselling among pregnant women who attend antenatal care at primary and higher level health facilities. METHODS: A community based study...

  17. [Acute myocardial infarction in women. Initial characteristics, management and early outcome. The FAST-MI registry].

    Science.gov (United States)

    Simon, T; Puymirat, E; Lucke, V; Bouabdallaoui, N; Lognoné, T; Aissaoui, N; Cohen, S; Ashrafpoor, G; Roul, G; Jouve, B; Levy, G; Charpentier, S; Grollier, G; Ferrières, J; Danchin, N

    2013-08-01

    To assess gender differences in characteristics, management, and hospital outcomes in patients participating in the French FAST-MI 2010 registry. Three thousand and seventy-nine patients hospitalised for ST-elevation (STEMI) or non-ST-elevation (NSTEMI) myocardial infarction in 213 French centres during a 1-month period at the end of 2010. Women account for 27% of the population and more frequently present with NSTEMI. They are 9 years older than men on average, although 25% of women with STEMI are less than 60 years of age. Management of STEMI is similar, after adjustment for baseline characteristics. However, fewer women are treated with primary percutaneous coronary angioplasty. In NSTEMI, although use of coronary angiography is similar, fewer women get treated with angioplasty. Most medications are used in a similar way in men and women, except thienopyridines, with fewer women receive prasugrel. After adjustment, in-hospital mortality is similar for men and women. Myocardial infarction is not specific to men: one out of four patients admitted for myocardial infarction is a woman. Initial management is rather similar for men and women, after taking into account differences in baseline characteristics. Percutaneous coronary angioplasty, however, remains less frequently used in women. In-hospital complications have become rarer and do not differ according to sex. Copyright © 2013. Published by Elsevier SAS.

  18. Associação entre depressão na perimenopausa e níveis séricos de estradiol e hormônio folículo-estimulante Association between depression in the perimenopause and serum levels of estradiol (E2 and follicle-stimulating hormone (FSH

    Directory of Open Access Journals (Sweden)

    Cláudio N Soares

    2000-03-01

    Full Text Available OBJETIVOS: A perimenopausa é freqüentemente associada ao surgimento de alterações físicas e emocionais. Estudos prévios indicam uma associação entre variações dos hormônios folículo-estimulante (FSH, luteinizante (LH bem como de estrógenos e o surgimento de transtornos do humor, particularmente depressão. Este estudo investigou a correlação entre mudanças nos níveis de estradiol (E2 e FSH e a sintomatologia depressiva em mulheres na perimenopausa. MÉTODOS: Cinqüenta mulheres foram recrutadas nos atendimentos de uma clínica de menopausa e de um serviço psiquiátrico para realização de ensaio clínico com uso de 17 b-estradiol ou placebo. Selecionaram-se mulheres em perimenopausa (idade entre 40 e 55 anos, presença de alterações vasomotoras, irregularidade menstrual nos últimos 6 meses e/ou amenorréia há no máximo 12 meses, níveis de FSH>20 UI/L e com diagnóstico de transtorno depressivo pelo DSM-IV (transtorno depressivo maior, transtorno distímico ou transtorno depressivo sem outra especificação. Dosagens séricas iniciais e finais (semana 12 de FSH e E2, bem como avaliações da sintomatologia depressiva (escores da MADRS foram analisadas e suas correlações investigadas. RESULTADOS: As pacientes apresentaram mudanças (pOBJECTIVES: Previous studies suggest that the perimenopause is a period of increased risk for physical and emotional disturbances. The intense fluctuation in hormone levels during the perimenopause has been associated with the presence of depressive symptoms. The present study investigated the association between levels of estradiol (E2 and follicle-stimulating hormone (FSH and the severity of depressive symptoms of women in the perimenopause. METHODS: Fifty perimenopausal women (age: 40-55 years, all meeting DSM-IV criteria for depressive disorders [major depressive disorder, dysthymia or depressive disorders NOS], with irregular periods and FSH levels > 20 IU/L were selected from a larger

  19. Association of Fatigue with Perceived Stress in Chinese Women with Early Stage Breast Cancer Awaiting Adjuvant Radiotherapy.

    Science.gov (United States)

    Ho, Rainbow T H; Kwan, Tracy T C; Cheung, Irene K M; Chan, Caitlin K P; Lo, Phyllis H Y; Yip, Paul S F; Luk, Mai-Yee; Chan, Cecilia L W

    2015-08-01

    Cancer-related fatigue (CRF) is common in women with breast cancer, but little is known of its relationship with perceived stress. We conducted a cross-sectional study to explore the associations of CRF with perceived stress, anxiety, depression, pain and sleep quality in 133 Chinese women (aged 25-68 years) with early stage breast cancer. The majority of women had completed surgery and chemotherapy and were awaiting radiotherapy. Self-administered questionnaires consisting of the Brief Fatigue Inventory, Perceived Stress Scale-10, Hospital Anxiety and Depression Scale, Brief Pain Inventory, and Pittsburgh Sleep Quality Index were used to collect data. Forty-five per cent of the women were severely fatigued. Compared with local healthy women and US breast cancer patients, the group's mean perceived stress score was significantly higher (both p perceived stress (β = 0.18, p = 0.032), higher anxiety (β = 0.30, p perceived stress was partially mediated by anxiety, suggesting a possible pathway from cancer and cancer treatment to CRF via stress appraisals and emotional distress. The findings indicate the importance of monitoring the psychological status of patients during treatment. Copyright © 2013 John Wiley & Sons, Ltd.

  20. Cycle and hormone changes during perimenopause: the key role of ovarian function.

    Science.gov (United States)

    Burger, Henry G; Hale, Georgina E; Dennerstein, Lorraine; Robertson, David M

    2008-01-01

    The menopausal transition is the stage in reproductive life commonly defined as commencing with the onset of menstrual irregularity. Classic studies of the endocrinology of the transition postulated the existence of inhibin in women to explain the observed increase in follicle-stimulating hormone (FSH) levels without a significant decrease in estradiol (E2). Descriptions were provided of cycle characteristics during the transition, emphasizing the unpredictability of the endocrine changes rather than the occurrence of an orderly and progressive decline in ovarian function. Women older than the age of 45 exhibited menstrual irregularity when the average number of primordial follicles per ovary decreased to approximately 100. Inhibin B is a major regulator of FSH secretion and a product of small antral follicles. Its levels respond to the early follicular phase increase and decrease in FSH. The age-related decrease in ovarian primordial follicle numbers, which is reflected in a decrease in the numbers of small antral follicles, leads to a decrease in inhibin B, which in turn leads to an increase in FSH, hypothesized to act as a stimulus to the maintenance of circulating E2 in the follicular phase until late in the transition. Concurrently, the concentrations of testosterone do not change significantly. Early follicular phase FSH levels in women reporting menstrual irregularity fluctuate markedly, with a more uniform increase in levels when no menses have occurred for at least 3 months. Anovulatory cycles occur at increased frequency in the last 30 months before final menses or menopause. In ovulatory cycles, FSH shows little, if any, increase, but anovulatory cycles are usually characterized by low levels of inhibin B, markedly increased levels of FSH, and low levels of E2. Thus, the heterogeneity of follicular phase FSH represents a mixture of ovulatory and anovulatory cycles. Longitudinal data indicate that both ovulatory and anovulatory cycles occur after entry

  1. 植物雌激素与激素替代疗法治疗围绝经期综合征的疗效比较%Comparison of effect of Phytoestrogens and Hormone Replacement Therapy in the treatment of Perimenopaus-al Syndrome

    Institute of Scientific and Technical Information of China (English)

    张新容; 张晓颜; 赖坚

    2015-01-01

    treatment,Kupperman score de-creased significantly(P ﹤ 0. 01). Compared with before treatment,two groups of patients after treatment,E2 and P were significantly in-creased,while FSH、LH、AKP、TC、TG were significantly reduced,and the difference was statistically significant(P ﹤ 0. 05). There was no significant difference efficacy between the two groups(P ﹥ 0. 05). Conclusion Phytoestrogens can effectively improve the clinical symp-toms of perimenopause syndrome,regulate hormone levels in perimenopausal syndrome,promote patient lipid metabolism,and no significant difference in the efficacy of hormone replacement therapy. Phytoestrogens also menopausal and postmenopausal women,cardiovascular pro-tective effect,and can prevent osteoporosis and prevent bone loss.

  2. Reduced prevalence of early preterm delivery in women with Type 1 diabetes and microalbuminuria--possible effect of early antihypertensive treatment during pregnancy

    DEFF Research Database (Denmark)

    Nielsen, L R; Kragh-Müller, Claus; Damm, P

    2006-01-01

    In normotensive women with Type 1 diabetes and microalbuminuria we previously found preterm delivery (Antihypertensive treatment was initiated in late pregnancy when preeclampsia was diagnosed and diastolic blood pressure > 90 mmHg. From April 2000 our routine...... was changed and early antihypertensive treatment with methyldopa was initiated if antihypertensive treatment was given prior to pregnancy, if urinary albumin excretion (UAE) was > 2 g/24 h, or blood pressure > 140/90 mmHg. The present study describes the impact of this more aggressive antiypertensive...... treatment in the prevalence of preterm delivery....

  3. Metformin exposure in early pregnancy and spontaneous abortions in women with polycystic ovary syndrome

    DEFF Research Database (Denmark)

    Lauszus, Finn; Viftrup-Lund, Mette; Gade, Melina

    2014-01-01

    Objective: We sought to determine whether metformin affects the rate of first trimester spontaneous abortions and congenital malformations in women with PCOS. Design. Consecutive series of metformin treated women with a questionnaire followup. Setting. Department of Gynecology and Obstetrics at H...

  4. High-Normal Estimated Glomerular Filtration Rate in Early-Onset Preeclamptic Women 10 Years Postpartum

    NARCIS (Netherlands)

    Paauw, N.D.; Joles, J.A.; Drost, J.T.; Verhaar, M.C.; Franx, A.; Navis, G.; Maas, A.H.E.M.; Lely, A.T.

    2016-01-01

    Women with a history of preeclampsia have a 5- to 12-fold increased risk to develop end-stage kidney disease. Previous observations in small cohorts suggest that former preeclamptic (fPE) women have subtle abnormalities in renal hemodynamics and renal function, which might predispose them to renal

  5. Food matrix and isoflavones bioavailability in early post menopausal women: A European clinical study

    NARCIS (Netherlands)

    Chanteranne, B.; Branca, F.; Kardinaal, A.; Wahala, K.; Braesco, V.; Ladroite, P.; Brouns, F.; Coxam, V.

    2008-01-01

    The estrogenic effects of soy isoflavones (IF) on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age

  6. High-Normal Estimated Glomerular Filtration Rate in Early-Onset Preeclamptic Women 10 Years Postpartum

    NARCIS (Netherlands)

    Paauw, Nina D.; Joles, Jaap A.; Drost, Jose T.; Verhaar, Marianne C.; Franx, Arie; Navis, Gerjan; Maas, Angela H. E. M.; Lely, A. Titia

    2016-01-01

    Women with a history of preeclampsia have a 5- to 12-fold increased risk to develop end-stage kidney disease. Previous observations in small cohorts suggest that former preeclamptic (fPE) women have subtle abnormalities in renal hemodynamics and renal function, which might predispose them to renal f

  7. Effect of hormone therapy on exercise capacity in early postmenopausal women.

    Science.gov (United States)

    Mercuro, Giuseppe; Saiu, Francesca; Deidda, Martino; Mercuro, Silvia; Vitale, Cristiana; Rosano, Giuseppe M C

    2007-10-01

    To compare the exercise capacity of postmenopausal women with matched premenopausal controls, as well as postmenopausal women before and after 3 months of hormone therapy (HT). This study examined the response to strenuous isotonic exercise in 30 women with recently developed menopause (age, mean+/-standard deviation, 50.6+/-1.1 years) without cardiovascular risk factors or diseases. Thirty premenopausal subjects, matched one-to-one for age and biophysical characteristics, were the control group. Postmenopausal women underwent examination before (T(0)) and 3 months after (T(1)) HT (oral 0.625 mg conjugated estrogen and 2.5 mg medroxyprogesterone acetate/day) with high-resolution ultrasound determination of peripheral flow-mediated vasodilation and an integrative cardiopulmonary test. Postmenopausal women showed an impairment of flow-mediated vasodilation (Pexercise intolerance, and there are benefits in introducing HT.

  8. Predictive value of serum β-hCG for early pregnancy outcomes among women with recurrent spontaneous abortion.

    Science.gov (United States)

    Liu, Yinglin; Liu, Yukun; Li, Xuejiao; Jiao, Xuedan; Zhang, Rui; Zhang, Jianping

    2016-10-01

    To examine peak serum levels of the β-subunit of human chorionic gonadotropin (β-hCG) for prediction of early pregnancy outcomes among women with recurrent spontaneous abortion (RSA). In a retrospective study, the medical records of pregnant women with a history of RSA treated at Sun Yat-sen Memorial Hospital, China, between January 2011 and July 2013 were reviewed. Serum β-hCG had been measured twice weekly from 5 to 13weeks of pregnancy, and pregnancy was monitored by transvaginal ultrasonography to 13(+6)weeks. Optimal cutoff for peak β-hCG level was determined by receiver operator characteristic curve analysis and Youden index. Women were divided into four groups on the basis of optimal peak β-hCG cutoff and pregnancy outcome (pregnancy at 13weeks or spontaneous abortion). Peak β-hCG levels and length of pregnancy at this peak were examined. Overall, 1240 patients were included. The optimal cutoff value of peak β-hCG was 88 468IU/L, with a sensitivity, specificity, positive predictive value, and negative predictive value for successful pregnancy of 95.6%, 88.0%, 95.6%, and 89.0%, respectively. A faster rise in β-hCG, higher peak β-hCG, and longer pregnancy length at peak β-hCG were associated with successful early pregnancy. A cutoff value of serum β-hCG of 88 000IU/L could be used to predict early pregnancy outcomes for women with a history of RSA. Copyright © 2016. Published by Elsevier Ireland Ltd.

  9. Knowledge of breast cancer and its early detection measures among rural women in Akinyele Local Government Area, Ibadan, Nigeria

    Directory of Open Access Journals (Sweden)

    Oladepo Oladimeji

    2006-11-01

    Full Text Available Abstract Background Breast cancer is the commonest cancer among women in Nigeria and globally. In Nigeria, late presentations of breast cancer cases have also been consistent for three decades. In an environment where there is no established national screening program for breast cancer, it is pertinent to assess the knowledge of breast cancer and its early detection measures. The objective of this study therefore, was to assess rural women's level of knowledge of breast cancer and its early detection measures. Methods The knowledge of various aspects of breast cancer; etiology, early warning signs, treatment modes and early detection measures; was assessed among women in two randomly selected health districts in Akinyele Local Government in Ibadan. The assessment was performed with the use of a self-structured validated questionnaire administered by trained interviewers to 420 women randomly selected from the two health districts. The various aspects of facts about breast cancer were scored and added together to determine respondents' level of knowledge Results The mean score of knowledge of breast cancer was 55.4 SD 5.4 (range of scores obtainable was 26–78, while the mean score for knowledge of early detection of breast cancer was 24.8 SD 2.3 (range of scores obtainable was 12–36. The leading source of information about breast cancer was "elders, neighbors and friends" and 63(15.4% acknowledged this source, while only 18 (4.4% respondents acknowledged health workers as source. Only 54 (13.3% claimed to have heard about breast self- examination (BSE however, and the leading source of information about BSE were health workers. Nine (2.2% of respondents claimed this source. Conclusion This study revealed that respondents lacked knowledge of vital issues about breast cancer and early detection measures. It also revealed that health workers were not forthcoming with information to the public thereby constituting a challenge to community health

  10. Nuclear Translocation of Nuclear Factor Kappa B in First Trimester Deciduas and Chorionic Villi in Early Spontaneous Miscarriage Women

    Directory of Open Access Journals (Sweden)

    Chun-fang Yan

    2010-02-01

    Full Text Available The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.

  11. High prepregnant body mass index is associated with early termination of full and any breastfeeding in Danish women

    DEFF Research Database (Denmark)

    Baker, Jennifer Lyn; Michaelsen, Kim F; Sørensen, Thorkild I A;

    2007-01-01

    maternal obesity, was modified by gestational weight gain, and still existed when there was greater social support for breastfeeding. DESIGN: Study participants (37 459 women) were drawn from the Danish National Birth Cohort. The association of prepregnant BMI and gestational weight gain......BACKGROUND: An association between high prepregnant body mass index (BMI) and early termination of breastfeeding has been observed, but this finding may have depended on the sociocultural context. OBJECTIVE: The objective was to determine whether this association was stronger with increasing...... with the termination of full or any breastfeeding by 1, 16, or 20 wk postpartum was assessed with logistic regression analyses, and the risk of early termination of full and any breastfeeding during the first 18 mo postpartum was assessed with Poisson regression analyses. RESULTS: The risk of early termination of any...

  12. MORPHOLOGICAL STUDIES OF OVARY AND UTERUS OF EARLY PREGNANT RATS AND WOMEN TREATED WITH MIFEPRISTONE

    Institute of Scientific and Technical Information of China (English)

    CHENWen-Jian; ZHANGLong-Sheng; YANGXin-Li; SHENGJi-Yun; ZHOUJie-Ling; WUXi-Rui

    1989-01-01

    In this paper, morphological studies of uterus and ovary during terminating early pregnancy with mifcpristonc Were reported. In the experimental studies, 24 hrs after inhering 10 mg / kg mifcpristonc to early pregnant rats, all embryos wcrc dead, with decidual cells

  13. Early uptake of HIV counselling and testing among pregnant women at different levels of health facilities – experiences from a community-based study in Northern Vietnam

    DEFF Research Database (Denmark)

    Nguyen Thi Thuy, Hanh; Gammeltoft, Tine; Rasch, Vibeke

    2011-01-01

    .0% of the women interviewed had attended antenatal care and 90.3% had been tested for HIV during their most recent pregnancy. Women who had their first antenatal checkup at primary health facilities were significantly more likely to be tested before 34 weeks of gestation (OR = 43.2, CI: 18.9-98.1). The reported......ABSTRACT: BACKGROUND: HIV counselling and testing for pregnant women is a key factor for successful prevention of mother to child transmission of HIV. Women's access to testing can be improved by scaling up the distribution of this service at all levels of health facilities. However, this strategy...... will only be effective if pregnant women are tested early and provided enough counselling. OBJECTIVE: To assess early uptake of HIV testing and the provision of HIV counselling among pregnant women who attend antenatal care at primary and higher level health facilities. METHODS: A community based study...

  14. Role of some biomarkers in chronic pelvic pain for early detection of endometriosis in infertile women

    Directory of Open Access Journals (Sweden)

    Ashraf Ahmed Foda

    2012-09-01

    Conclusion: Serum IL-6 and TNF-α levels are reliable non-invasive biomarkers for the diagnosis of early stages of endometriosis because they increased significantly in early cases than in late cases. CA125, Hs-CRP & VEGF are significantly increased in late cases, so they cannot be used for early diagnosis.

  15. Pregnancy planning and lifestyle prior to conception and during early pregnancy among Danish women

    DEFF Research Database (Denmark)

    Backhausen, Mette G.; Ekstrand, Maria; Tydén, Tanja

    2014-01-01

    Objective To investigate the extent to which Danish women attending antenatal care plan their pregnancies and to determine the association between pregnancy planning and the intake of folic acid, alcohol consumption and smoking habits prior to conception and before the 16th week of gestation....... Methods A cross-sectional survey of 258 women. Main outcome measures: intake of folic acid, alcohol consumption and smoking. Pregnancy planning was assessed by the London Measure of Unplanned Pregnancy (LMUP) and the five graded Swedish Pregnancy Planning Scale. Results Most (77%) of the participants...... reported that their pregnancies were very or fairly well planned. Higher median LMUP scores were observed in women taking folic acid (p...

  16. Quality of the relationship and menopausal symptoms of menopausal women

    Directory of Open Access Journals (Sweden)

    Karolina Jarecka

    2016-10-01

    Full Text Available Background The aim of this study was to evaluate the occurrence and intensity of menopausal symptoms, taking into account the length of one’s relationship, its nature and one’s assessment of it. Participants and procedure The study included 200 women between the ages of 45 and 68, with secondary or higher education, married or in cohabiting relationships. Women were divided into three groups depending on the experience related to menopause: premenopause (46 respondents, perimenopause (75 respondents, and postmenopause (79 respondents. The study used a survey of self-design, the “Women’s Health” Questionnaire (WHQ by M. Hunter, and the “Partner Relations Questionnaire” (PFB by K. Hahlweg. Results Most menopausal symptoms – including those of the greatest severity – are experienced by women in perimenopausal and postmenopausal phases, but one’s own relationship’s assessment is the lowest in postmenopausal women. In this group of women, relevant and significant relations between the dimensions of the quality of the relationship and the menopausal symptoms are the most numerous. The most essential assessment was the one relating to intimacy – its poor evaluation is accompanied by higher intensity of experienced depression symptoms, somatic symptoms, and disorders of memory and concentration, sex and sleep, and also the sum of menopausal symptoms is higher. In all three groups, no significant differences in the severity of menopausal symptoms were observed between women in marital and cohabiting relationships. In women in the perimenopausal phase, the shorter the length of the relationship (its seniority, the greater is the severity of sexual dysfunction symptoms, whereas in women in the postmenopausal stage, along with the length of the relationship, the severity of psychological and somatic symptoms increases. Conclusions One should find that the perimenopausal and postmenopausal phases are particularly difficult for women

  17. Environmental sensitivity as a trigger of erythema nodosum and perimenopausal symptoms.

    Science.gov (United States)

    Horwitz, Randy; Maizes, Victoria

    2017-08-01

    A 45-year-old woman presented to the University of Arizona Integrative Medicine Clinic for advice on managing recurrent erythema nodosum (EN), along with recent onset perimenopausal symptoms. Her painful EN flares had occurred two to six times per year over the past 14 years, yet had attenuated over the past 5 years until recently, and she presented with bilateral EN lesions on the shins. An environmental exposure history revealed that a new plastic-containing water pot had been introduced at her office just prior to her latest EN flare. She was told to eliminate environmental exposure to plastics, including this new coffee pot. She eliminated exposures to heated plastics, and replaced her coffee pot with a stainless steel one. Within weeks of removing these potential environmental triggers, her EN lesions cleared completely, and her menses normalised. An unintentional re-exposure to plastics 2 months later resulted in an EN recurrence within 2 hours. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  18. A Primary Care-Based Early Childhood Nutrition Intervention: Evaluation of a Pilot Program Serving Low-Income Hispanic Women.

    Science.gov (United States)

    Watt, Toni Terling; Appel, Louis; Lopez, Veronica; Flores, Bianca; Lawhon, Brittany

    2015-12-01

    Nutrition in early childhood can significantly impact physical and mental health outcomes for children. However, research on broadly defined pre/postnatal nutrition interventions is sparse. The present study is a process and outcome evaluation of a primary care-based nutrition intervention targeting low-income Hispanic women. Pregnant women enrolled in the program were in their first trimester and received services through their 6-month well child check. The program provided vouchers for fruits and vegetables from the local farmers' market, nutrition classes, cooking classes, and lactation counseling. We conducted a prospective study of program participants (n = 32) and a comparable group of women for whom the program was not available (n = 29). Panel survey data measured maternal diet, exercise, stress, depression, social support, infant feeding practices, and demographics. Outcome measures obtained from medical records included pregnancy weight gain, infant weight at 6 and 12 months, and infant development at 9 months. Findings reveal that the program was not associated with infant weights. However, despite similar profiles at baseline, women in the intervention group were more likely than women in the comparison group to have significant improvements in diet, exercise, and depression (p ≤ .05). In addition, participants were more likely to breastfeed (p = .07) and their infants were more likely to pass the ages and stages developmental screen (p = .06) than women in the comparison group. The study was limited by a lack of random assignment and small samples. However, the breadth and size of the effects suggest pre/postnatal nutrition interventions integrated into primary care warrant additional investigation.

  19. Increasing Healthy Start food and vitamin voucher uptake for low income pregnant women (Early Years Collaborative Leith Pioneer Site).

    Science.gov (United States)

    Mackenzie, Graham; Dougall, Angela

    2016-01-01

    Poverty has a detrimental impact on health and wellbeing. Healthy Start food and vitamin vouchers provide support for low income families across the UK, but at least 25% of eligible women and children miss out. We set out to increase uptake, with an aim of 90% of eligible women and children (n~540 eligible, varying over time) receiving vouchers in the initial team's catchment area by December 2015. Starting with one midwife and one pregnant woman in March 2014 we used the model for improvement to identify ways to improve documentation, sign up, and referral. Weekly data on process measures and monthly data on voucher receipt were plotted on run charts. Comparing medians for January-June 2014 and March-August 2015 there was a 13.3% rise in voucher receipt in Lothian (increase from 313 to 355 women), versus an 8.4% decline for the rest of Scotland (fall from 1688 to 1546 women). Figures varied by team, influenced by staff, family, and area factors. The initial aim proved unrealistic, as signing up a woman for vouchers increases both the numerator and denominator. Accordingly, the percentage uptake has not increased at a regional level (remains at 75%), though the figure for the initiating team ("team 3" in graphs) has increased from 73.0% (January 2014) to 79.0% (November 2015). We have continued testing, achieving recent increases in the number of women referred for welfare rights advice on benefits, tax credits, employment rights, childcare, and debt, securing on average £4,500 per client during 2015/16 (£404k for 89 clients by mid September 2015). This improvement project, part of the Early Years Collaborative in Scotland, has had a measureable impact on pregnant women across Lothian. Success has relied on testing, an electronic maternity record, rapid dissemination of findings through direct engagement with clinical teams, and persistence. Our findings have relevance across the UK, particularly at a time of worsening finances for many families.

  20. Validation of the early childhood attitude toward women in science scale (ECWiSS): A pilot administration

    Science.gov (United States)

    Mulkey, Lynn M.

    The intention of this research was to measure attitudes of young children toward women scientists. A 27-item instrument, the Early Childhood Women in Science Scale (ECWiSS) was validated in a test case of the proposition that differential socialization predicts entry into the scientific talent pool. Estimates of internal consistency indicated that the scale is highly reliable. Known groups and correlates procedures, employed to determine the validity of the instrument, revealed that the scale is able to discriminate significant differences between groups and distinguishes three dimensions of attitude (role-specific self-concept, home-related sex-role conflict, and work-related sex-role conflict). Results of the analyses also confirmed the anticipated pattern of correlations with measures of another construct. The findings suggest the utility of the ECWiSS for measurement of early childhood attitudes in models of the ascriptive and/or meritocratic processes affecting recruitment to science and more generally in program and curriculum evaluation where attitude toward women in science is the construct of interest.

  1. Investigation of herb-drug interactions with ginkgo biloba in women receiving hormonal treatment for early breast cancer.

    Science.gov (United States)

    Vardy, Janette; Dhillon, Haryana M; Clarke, Stephen J; Olesen, Inger; Leslie, Felicity; Warby, Anne; Beith, Jane; Sullivan, Anne; Hamilton, Anne; Beale, Philip; Rittau, Anneliese; McLachlan, Andrew J

    2013-12-01

    Women receiving treatment for breast cancer commonly ingest herbal medicines. Little is known about the potential for herb-drug interactions in this population. The aim of this study is to investigate the effect of ginkgo biloba co-administration on the pharmacokinetics of tamoxifen, anastrozole and letrozole. This was a prospective open-label cross-over study in 60 women with early stage breast cancer taking either tamoxifen, anastrozole or letrozole (n=20/group). Participants received ginkgo biloba (EGb 761) for 3 weeks (120 mg twice daily). Trough concentrations of drugs were measured before and after ginkgo biloba treatment using LC-MS/MS. Toxicities were graded according to National Cancer Institute Common Terminology Criteria for Adverse Events. Trough concentrations before and after treatment with ginkgo biloba were not significantly different for tamoxifen (93.5 ± 29.0, 86.5 ± 25.3 ng/mL; p=0.16), letrozole (91.1 ± 50.4, 89.6 ± 52.14 ng/mL; p=0.60) or anastrozole (29.1 ± 8.6, 29.1 ± 7.6 ng/mL; p=0.97). Ginkgo biloba was well tolerated, with no difference in toxicity during ginkgo biloba. Co-administration of ginkgo biloba does not significantly affect the pharmacokinetics of tamoxifen, anastrozole or letrozole. There was no difference in the toxicity profile of hormone therapy with ginkgo biloba use in women with early stage breast cancer.

  2. The Order of Widows: what the early church can teach us about older women and health care.

    Science.gov (United States)

    Kaveny, M Cathleen

    2005-04-01

    This article argues that the early Christian "order of widows" provides a fruitful model for Christian ethicists struggling to address the medical and social problems of elderly women today. After outlining the precarious state of the "almanah"--or widow--in biblical times, it describes the emergence of the order of widows in the early Church. Turning to the contemporary situation, it argues that demographics both in the United States and around the globe suggest that meeting the needs of elderly women will become an enormous challenge in the years to come. The order of widows illustrates a three-fold conception of solidarity that has immediate implications today. That conception of solidarity encourages us: 1) to identify the unique medical needs of elderly women (e.g., osteoporosis); 2) to find ways of overcoming their societal isolation, which can increase their risk of medical and psychological problems; and 3) to develop strategies for enabling them to remain contributing members of the community for as long as possible.

  3. Barriers to early presentation and diagnosis of breast cancer among African women living in sub-Saharan Africa

    Science.gov (United States)

    Akuoko, Cynthia Pomaa; Armah, Ernestina; Sarpong, Theresa; Quansah, Dan Yedu; Amankwaa, Isaac

    2017-01-01

    Background Breast cancer (BC) has been described as the leading cause of cancer deaths among women especially in the developing world including sub Saharan Africa (SSA). Delayed presentation and late diagnosis at health facilities are parts of the contributing factors of high BC mortality in Africa. This review aimed to appraise the contributing factors to delayed breast cancer presentation and diagnosis among SSA women. Methods Five databases encompassing medical and social sciences were systematically searched using predefined search terms linked with breast cancer presentation and diagnosis and sub Saharan Africa. Reference lists of relevant papers were also hand searched. Quality of quantitative and qualitative articles were assessed using the National Institute of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies and the Critical Appraisal Skills Programme (CASP) quality appraisal checklist. Thematic analysis was used to synthesize the qualitative studies to integrate findings. Results Fourteen (14) quantitative studies, two (2) qualitative studies and one (1) mixed method study merited inclusion for analysis. This review identified low knowledge of breast cancer among SSA women. This review also found lack of awareness of early detection treatment, poor perception of BC, socio-cultural factors such as belief, traditions and fear as factors impacting African women’s health seeking behavior in relation to breast cancer. Conclusion Improving African women’s knowledge and understanding will improve behaviors related to breast cancer and facilitate early presentation and detection and enhance proper management and treatment of breast cancer. PMID:28192444

  4. Hungry women: sin and rebellion through food and music in the early modern era

    Directory of Open Access Journals (Sweden)

    Gioia Filocamo

    2015-01-01

    Full Text Available Longing for food has always had different implications for men and women: associated with power and strength for men, it tends to have a worrying proximity to sexual pleasure for women. Showing an interesting parallelism throughout the Cinquecento, Italian humanists and teachers insisted on forbidding women music and gluttony. Food and music were both considered dangerous stimulants for the female senses, and every woman was encouraged to consider herself as a kind of food to be offered to the only human beings authorized to feel and satisfy desires: men and babies. Women could properly express themselves only inside monastic circles: the most prolific female composer of the seventeenth century was a nun, as was the first woman who wrote down recipes. Elaborate music and food became the means to maintain a lively relationship with the external world. Moreover, nuns also escaped male control by using the opposite system of affirming themselves through fasting and mortifying the flesh.

  5. Facebook Advertisements for Inexpensive Participant Recruitment among Women in Early Pregnancy

    Science.gov (United States)

    Arcia, Adriana

    2014-01-01

    Facebook advertisements were used to recruit nulliparous women in the first 20 weeks of pregnancy for an online survey about their childbirth preferences. A campaign of ads was targeted to women, aged 18 to 44 years, residing in the United States. The ads were viewed 10,577,381 times by 7,248,985 unique Facebook users over 18 weeks in 2011. The ad…

  6. Facebook Advertisements for Inexpensive Participant Recruitment among Women in Early Pregnancy

    Science.gov (United States)

    Arcia, Adriana

    2014-01-01

    Facebook advertisements were used to recruit nulliparous women in the first 20 weeks of pregnancy for an online survey about their childbirth preferences. A campaign of ads was targeted to women, aged 18 to 44 years, residing in the United States. The ads were viewed 10,577,381 times by 7,248,985 unique Facebook users over 18 weeks in 2011. The ad…

  7. The early use of appropriate prophylactic antibiotics in susceptible women for the prevention of preterm birth of infectious etiology

    DEFF Research Database (Denmark)

    Joergensen, Jan Stener; Weile, Louise Katrine Kjær; Lamont, Ronald F

    2014-01-01

    /meta-analyses have been conducted but none has simultaneously addressed the optimal choice of agent, patient and timing of intervention. We conclude that inappropriate antibiotics used in inappropriate women at inappropriately late gestations do not reduce preterm birth. Conversely, a focused systematic review....../meta-analysis, which targeted the use of clindamycin before 22 weeks gestation, in women with objective evidence of abnormal genital tract flora, demonstrated that clindamycin produced a significant decrease in late miscarriage and preterm birth.......INTRODUCTION: Preterm birth is the major cause of perinatal mortality and morbidity in high-income countries. The etiology of preterm birth is multifactorial but there is overwhelming evidence to implicate infection as a major cause. Abnormal genital tract flora in early pregnancy is predictive...

  8. Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women

    DEFF Research Database (Denmark)

    Østerdal, M L; Strøm, M; Klemmensen, A K;

    2008-01-01

    OBJECTIVE: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia. DESIGN: Prospective cohort. SETTING: Denmark. POPULATION: A total of 85,139 pregnant Danish women, recruited between 1996 and 2002. METHODS: The authors assessed leisure time physical...... activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were...... adjusted for by logistic regression. MAIN OUTCOME MEASURES: Pre-eclampsia and severe pre-eclampsia. RESULTS: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1...

  9. Breasts and breastfeeding: perspectives of women in the early months after birthing.

    Science.gov (United States)

    Harris, Mary; Nayda, Robyn; Summers, Annette

    2003-11-01

    Over recent years there has been widespread recognition and education about the benefits of breastfeeding. However as many Australian women breastfeed for only a few weeks, education alone appears inadequate to improve breastfeeding duration. This study explores other influences on breastfeeding by looking at women's perceptions of their breasts in relation to their breastfeeding experiences. Six women were recruited at approximately three months postpartum. The hermeneutic phenomenology of Heidegger (1962) and Gadamer (1975) was the chosen methodology. Individual, unstructured, indepth, conversational interviews were employed and analysed using Colaizzi's (1978) framework, which was modified to manage the large amount of data. Two patterns of differing focus emerged from the interviews, mixed images of the breasts and journey through the unknown of breastfeeding and new motherhood. Each pattern was divided into six and seven related themes respectively.

  10. Ectopic fat and adipokines in metabolically benign overweight/obese women: the Kronos Early Estrogen Prevention Study.

    Science.gov (United States)

    Ogorodnikova, Alexandra D; Khan, Unab I; McGinn, Aileen P; Zeb, Irfan; Budoff, Matthew J; Harman, S M; Miller, Virginia M; Brinton, Eliot A; Manson, JoAnn E; Hodis, Howard N; Merriam, George R; Cedars, Marcelle I; Taylor, Hugh S; Naftolin, Frederick; Lobo, Rogerio A; Santoro, Nanette; Wildman, Rachel P

    2013-08-01

    It is unclear why despite a comparable cardiometabolic risk profile, "metabolically benign" overweight/obese individuals show an elevated risk of cardiovascular disease compared to normal weight individuals. In cross-sectional analyses, we compared levels of ectopic fat (epicardial, pericardial, and hepatic fat) and adipokines (leptin, soluble leptin receptor, and high molecular weight [HMW] adiponectin) among metabolically benign (MBO) and at-risk overweight/obese (ARO), and metabolically benign normal weight (MBNW) women, screened for the Kronos Early Estrogen Prevention Study. We defined "metabolically benign" with ≤ 1, and "at-risk" with ≥2 components of the metabolic syndrome. Compared to MBO women, ARO women had significantly elevated odds of being in the top tertile of epicardial fat (OR: 1.76, 95% CI: 1.04-2.99), hepatic fat (OR: 1.90, 95% CI:1.12-3.24) and leptin (OR: 2.15, 95% CI: 1.23-3.76), and the bottom tertile of HMW-adiponectin (OR: 2.90, 95% CI: 1.62-5.19). Compared to MBNW women, MBO women had significantly higher odds of being in the top tertile of epicardial fat (OR: 5.17, 95% CI: 3.22-8.29), pericardial fat (OR: 9.27, 95% CI: 5.52-15.56) and hepatic fat (OR: 2.72, 95% CI: 1.77-4.19) and the bottom tertile of HMW adiponectin levels (OR: 2.51, 95% CI: 1.60-3.94). Levels of ectopic fat and the adverse adipokine profile increase on a continuum of BMI, suggesting that the metabolically benign phenotype may be a transient state. Copyright © 2013 The Obesity Society.

  11. Early- and late-onset pelvic inflammatory disease among women with cervical Chlamydia trachomatis infection at the time of induced abortion--a follow-up study

    DEFF Research Database (Denmark)

    Sørensen, Jette Led; Thranov, I; Hoff, G

    1994-01-01

    in order to detect an early- and late-onset pelvic inflammatory disease (PID). For statistical analysis survival analysis by Kaplan-Meir estimates and Mantel-Cox test were carried out. Untreated women with C. trachomatis infection at the time of abortion had a cumulative risk of 72% of developing early and...

  12. The Effect of Education on the Early Diagnosis of Breast and Cervix Cancer on the Women's Attitudes and Behaviors Regarding Participating in Screening Programs.

    Science.gov (United States)

    Kocaöz, Semra; Özçelik, Hanife; Talas, Melek Serpil; Akkaya, Fulya; Özkul, Fatma; Kurtuluş, Ayla; Ünlü, Fahriye

    2017-03-11

    The objective of this paper was to define the effect of education on the early diagnosis of breast and cervix cancer on the women's attitudes and behaviors regarding participating in Cancer Early Diagnosis, Screening and Training Centers-CEDSTC screening programs. This semi-experimental study was completed with 342 women. The data were collected with forms "Champion's Health Belief Model Scale Breast Cancer-HBMSBC" and "Health Belief Model Scale for Cervical Cancer and the Pap Smear Test-HBMSCCPST." When the women's health beliefs before and after 6 months of the education about the early diagnosis of breast and cervical cancers are considered, it is seen that the HBMSBC subscales health motivation, breast self-examination (BSE), and evasion to mammography (MMG) decreased and BSE self-efficacy and MMG benefit attitudes increased and HBMSCCPST subscales pap smear benefit attitudes increased and evasion to pap smear attitude decreased (p < 0.05). Six months after the education, 28.4% of the women had undergone MMG, 69.9% had performed BSE, and 33.6% had undergone a pap smear test. Education regarding early diagnosis of breast and cervix cancer was found to have positive effects on the health behaviors of the women related to BSE, MMG, and pap smear tests. The women require professional education program for increasing their attitudes and behaviors for CEDSTC screening programs. We suggest regularly providing education to increase participation in early screening programs.

  13. Persistent organic pollutants and early menopause in U.S. women.

    Directory of Open Access Journals (Sweden)

    Natalia M Grindler

    Full Text Available Endocrine-disrupting chemicals (EDCs adversely affect human health. Our objective was to determine the association of EDC exposure with earlier age of menopause.Cross-sectional survey using National Health and Nutrition Examination Survey (NHANES data from 1999 to 2008 (n = 31,575 females. Eligible participants included: menopausal women >30 years of age; not currently pregnant, breastfeeding, using hormonal contraception; no history of bilateral oophorectomy or hysterectomy. Exposures, defined by serum lipid and urine creatinine-adjusted measures of EDCs, data were analyzed: > 90th percentile of the EDC distribution among all women, log-transformed EDC level, and decile of EDC level. Multi linear regression models considered complex survey design characteristics and adjusted for age, race/ethnicity, smoking, body mass index. EDCs were stratified into long (>1 year, short, and unknown half-lives; principle analyses were performed on those with long half-lives as well as phthalates, known reproductive toxicants. Secondary analysis determined whether the odds of being menopausal increased with EDC exposure among women aged 45-55 years.This analysis examined 111 EDCs and focused on known reproductive toxicants or chemicals with half-lives >1 year. Women with high levels of β-hexachlorocyclohexane, mirex, p,p'-DDE, 1,2,3,4,6,7,8-heptachlorodibenzofuran, mono-(2-ethyl-5-hydroxyhexyl and mono-(2-ethyl-5-oxohexyl phthalate, polychlorinated biphenyl congeners -70, -99, -105, -118, -138, -153, -156, -170, and -183 had mean ages of menopause 1.9 to 3.8 years earlier than women with lower levels of these chemicals. EDC-exposed women were up to 6 times more likely to be menopausal than non-exposed women.This study of a representative sample of US women documents an association between EDCs and earlier age at menopause. We identified 15 EDCs that warrant closer evaluation because of their persistence and potential detrimental effects on ovarian function

  14. Comparison of quantitative ultrasound and dual X-ray absorptiometry in estrogen-treated early postmenopausal women

    DEFF Research Database (Denmark)

    Sørensen, H A; Jørgensen, N R; Jensen, J E

    2001-01-01

    Identifying individuals at risk of developing osteoporosis is important in order to initiate early treatment. Many new techniques have been proposed as alternatives for DXA-scanning. Some of these alternatives certainly have advantages, but none have so far been demonstrated to predict fractures ......, but it was unable to identify women with low BMD, although it might be able to identify persons not at risk of osteoporosis. Low QUS values should be followed by a regular DXA measurement to confirm the presence of osteoporosis.......Identifying individuals at risk of developing osteoporosis is important in order to initiate early treatment. Many new techniques have been proposed as alternatives for DXA-scanning. Some of these alternatives certainly have advantages, but none have so far been demonstrated to predict fractures...

  15. Major depression during and after the menopausal transition: Study of Women's Health Across the Nation (SWAN).

    Science.gov (United States)

    Bromberger, J T; Kravitz, H M; Chang, Y-F; Cyranowski, J M; Brown, C; Matthews, K A

    2011-09-01

    It is unclear whether risk for major depression during the menopausal transition or immediately thereafter is increased relative to pre-menopause. We aimed to examine whether the odds of experiencing major depression were greater when women were peri- or post-menopausal compared to when they were pre-menopausal, independent of a history of major depression at study entry and annual measures of vasomotor symptoms (VMS), serum levels of, or changes in, estradiol (E2), follicular stimulating hormone (FSH) or testosterone (T) and relevant confounders. Participants included the 221 African American and Caucasian women, aged 42-52 years, who were pre-menopausal at entry into the Pittsburgh site of a community-based study of menopause, the Study of Women's Health Across the Nation (SWAN). We conducted the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) to assess diagnoses of lifetime, annual and current major depression at baseline and at annual follow-ups. Psychosocial and health factors, and blood samples for assay of reproductive hormones, were obtained annually. Women were two to four times more likely to experience a major depressive episode (MDE) when they were peri-menopausal or early post-menopausal. Repeated-measures logistic regression analyses showed that the effect of menopausal status was independent of history of major depression and annually measured upsetting life events, psychotropic medication use, VMS and serum levels of or changes in reproductive hormones. History of major depression was a strong predictor of major depression throughout the study. The risk of major depression is greater for women during and immediately after the menopausal transition than when they are pre-menopausal.

  16. Early versus Late Admission to Labor Affects Labor Progression and Risk of Cesarean Section in Nulliparous Women.

    Science.gov (United States)

    Mikolajczyk, Rafael T; Zhang, Jun; Grewal, Jagteshwar; Chan, Linda C; Petersen, Antje; Gross, Mechthild M

    2016-01-01

    Rates of cesarean section increase worldwide, and the components of this increase are partially unknown. A strong role is prescribed to dystocia, and at the same time, the diagnosis of dystocia is highly subjective. Previous studies indicated that risk of cesarean is higher when women are admitted to the hospital early in the labor. We examined data on 1,202 nulliparous women with singleton, vertex pregnancies and spontaneous labor onset. We selected three groups based on cervical dilatation at admission: early (0.5-1.5 cm, N = 178), intermediate (2.5-3.5 cm, N = 320), and late (4.5-5.5 cm, N = 175). The Kaplan-Meier estimator was used to analyze the risk of delivery by cesarean section at a given dilatation, and thin-plate spline regression with a binary outcome (R library gam) to assess the form of the associations between the cesarean section in either the first or second stage versus vaginal delivery and dilatation at admission. Women who were admitted to labor early had a higher risk of delivery by cesarean section (18 versus 4% in the late admission group), while the risk of instrumental delivery did not differ (24 versus 24%). Before 4 cm dilatation, the earlier a woman was admitted to labor, the higher was her risk of delivery by cesarean section. After 4 cm dilatation, however, the relationship disappeared. These patterns were true for both first and second stage cesarean deliveries. Oxytocin use was associated with a higher risk of cesarean section only in the middle group (2.5-3.5 cm dilatation at admission). Early admission to labor was associated with a significantly higher risk of delivery by cesarean section during the first and second stages. Differential effects of oxytocin augmentation depending on dilation at admission may suggest that admission at the early stage of labor is an indicator rather than a risk factor itself, but admission at the intermediate stage (2.5-3.5 cm) becomes a risk factor itself. Further research is

  17. Relationship among social factors,sex hormone and perimenopausal depression%社会因素和性激素与围绝经期抑郁症的相关研究

    Institute of Scientific and Technical Information of China (English)

    惠凌云; 王亚文; 张琳; 冯艾; 于学文

    2014-01-01

    目的:探讨社会因素以及性激素水平与围绝经期抑郁症高发的关系。方法采用汉密尔顿抑郁量表( HAMD-17)及国际疾病分类( ICD-10)中“抑郁发作”的诊断标准筛查入选研究对象。收集79名围绝经期抑郁症和58名围绝经期非抑郁症研究对象的一般资料和外周血标本。采用电化学发光法检测血清中的雌二醇( E2)、睾酮( T)、孕酮( P)、黄体生成素( LH)和卵泡刺激素( FSH)水平。结果围绝经期抑郁症组睡眠障碍和慢性病发生率高于非抑郁症组(χ2=4.700,P=0.030;χ2=4.866,P=0.027)。围绝经期抑郁症组E2、T、P水平均低于非抑郁症组( z=-3.175,P=0.001;z=-3.726,P<0.000;z=-2.868,P=0.004)。 HAMD评分与E2、T、P均存在负相关关系( r=-0.284,P=0.001;r=-0.389,P=0.000;r=-0.352,P=0.000)。Logistic回归分析显示E2、T、P水平高是抑郁症发生的保护因素[OR(95%CI)分别为:3.851(1.347~11.785),P=0.014;4.580(1.298~14.132),P=0.012;1.864(0.984~3.942),P=0.049)]。结论睡眠障碍、慢性病、E2、T、P水平与围绝经期抑郁症的发生相关,E2、T、P水平高是围绝经期抑郁症发生的保护因素。%[ Abatract] Objective To explore the relationship among social factors, sex hormone levels and the high incidence of perimenopausal depressive disorder.Methods Subjects were recruited with the diagnosis criteria for depressive onset in HAMD-17 and international classification of disease-10 (ICD-10).The general data and peripheral blood samples of 79 patients with depressive disorder and those of 58 women without depressive disorder were collected to detect the levels of estrogen ( E2 ) , testosterone ( T) , progesterone ( P) , luteinizing hormone ( LH) and follicle-stimulating hormone ( FSH) with electrochemiluminescence

  18. 戊酸雌二醇预防围绝经期、绝经后骨质疏松的系统评价%Estradiol Valerate for the Prevention of Perimenopausal and Postmenopausal Osteoporosis: A Systematic Review

    Institute of Scientific and Technical Information of China (English)

    黄璐; 许良智

    2012-01-01

    postmenopausal women.Methods Taking "randomized controlled trial","osteoporosis",and "estradiol valerate" as key words,we searched Medline (1950 to March 2012),EMbase (1974 to March 2012),Cochrane Library Clinical Trial Database (Issue 1,2012),Chinese Biomedical Literature Database (CBMdisc,1979 to March 2012),China Academic Journal Network Database (CNKI,1994 to March 2012),and Chinese Science & Technology Journal Database (VIP,1989 to March 2012).Some related journals were hand searched as well.All randomized controlled trials (RCTs) about E2 V to prevent the occurrence of osteoporosis in perimenopausal and postmenopausal women were collected.The quality of included RCTs was evaluated and meta-analysis was conducted by the Cochrane Collaboration's software RevMan 4.2.10.Results Four RCTs involving 1048 subjects were included.E2V alone or in combination with CPA OR MPA to prevent the occurrence of osteoporosis in perimenopausal and postmenopausal women.Meta-analysis showed,the increase of bone material density (BMD) of lumbar vertebrae and femoral neck in E2V+MPA or E2V+CPA group were better than that in control group ; the increases of BMD of lumbar vertebrae and femoral neck are comparable with 1.0 mg versus 1.5 mg E2V (both with MPA added),and 1.0 mg versus 2.0 mg E2V (both with MPA added).No significant difference was found in the efficacy of using small and larger doses of E2V to prevent osteoporosis.Conclusions E2V is effective in the prevention and treatment of OP in perimenopausal and postmenopausal,with the increase of the BMD of lumbar vertebrae and femoral neck.Small doses of E2V are recommended to prevent OP in perimenopausal and postmenopausal women.

  19. Possibilities for the early detection of hypertensive disease in pregnant women

    Directory of Open Access Journals (Sweden)

    Ye. B. Savinova

    2012-01-01

    Full Text Available Objective: to evaluate morphofunctional changes in the cardiovascular system of pregnant women with arterial hypertension (AH to detectchronic AH - hypertensive disease.Subjects and methods. 126 pregnant women with AH (at 28–34 weeks gestation; mean age 26.1 ± 1.7 years were examined. All the pregnantwomen underwent assessment of risk factors for AH, double measurement of office blood pressure, 24-hour blood pressure monitoring, electrocardiography, carotid ultrasonography, a microalbumin urine test, and eyeground examination. The pattern of AH was specified 12 weeks after childbirth.Results. Chronic AH – hypertensive disease – was diagnosed in 51 % of the examined pregnant women with AH. There was a considerable spread of risk factors for AH in this patient group. 26 % of them were found to have lesions of target organs (heart and/or arterial vessels; the rate of microalbuminuria registration was 41 %.Conclusion. Among our examined group of pregnant patients with AH, the prevalence of hypertensive disease is 51 %. In the identified patientgroup, cardiac and arterial vascular changes that could be considered as target organ lesions were found in almost a third of cases. Pregnant women with AH need to be meticulously examined and followed up by a therapist and a cardiologist in the postpartum period.

  20. Higher filtration fraction in formerly early-onset preeclamptic women without comorbidity

    NARCIS (Netherlands)

    Toering, Tsjitske J.; van der Graaf, Anne Marijn; Visser, Folkert W.; Groen, Henk; Faas, Marijke M.; Navis, Gerjan; Lely, A. Titia

    2015-01-01

    Formerly preeclamptic women have an increased risk for developing end-stage renal disease, which has been attributed to altered renal hemodynamics and abnormalities in the renin-angiotensin-aldosterone system. Whether this is due to preeclampsia itself or to comorbid conditions is unknown. Renal hem

  1. Increased Brain Connectivity In Early Postmenopausal Women with Subjective Cognitive Impairment

    Directory of Open Access Journals (Sweden)

    Jennifer N Vega

    2016-09-01

    Full Text Available Cognitive changes after menopause are a common complaint, especially as the loss of estradiol at menopause has been hypothesized to contribute to the higher rates of dementia in women. To explore the neural processes related to subjective cognitive complaints, this study examined resting state functional connectivity in 31 postmenopausal women (aged 50-60 in relationship to cognitive complaints following menopause. A cognitive complaint index was calculated using responses to a 120-item questionnaire. Seed regions were identified for resting state brain networks important for higher-order cognitive processes and for areas that have shown differences in volume and functional activity associated with cognitive complaints in prior studies. Results indicated a positive correlation between the executive control network and cognitive complaint score, weaker negative functional connectivity within the frontal cortex, and stronger positive connectivity within the right middle temporal gyrus in postmenopausal women who report more cognitive complaints. While longitudinal studies are needed to confirm this hypothesis, these data are consistent with previous findings suggesting that high levels of cognitive complaints may reflect changes in brain connectivity and may be a potential marker for the risk of late-life cognitive dysfunction in postmenopausal women with otherwise normal cognitive performance.

  2. Early pregnancy loss in women stimulated with gonadotropin-releasing hormone antagonist protocols according to oral contraceptive pill pretreatment.

    Science.gov (United States)

    Bellver, José; Albert, Carmen; Labarta, Elena; Pellicer, Antonio

    2007-05-01

    To evaluate and compare the risk of early pregnancy loss in patients stimulated with GnRH antagonist protocols according to oral contraceptive pill (OCP) pretreatment. Retrospective case-control study. Instituto Valenciano de Infertilidad. University of Valencia. Spain. One thousand five hundred thirty-nine patients, aged <36, stimulated with GnRH antagonists for IVF between January 1, 2000 and November 1, 2005. Reproductive outcome was compared based on the application (or not) of OCP pretreatment: 944 women were included in the OCP group and 595 in the non-OCP group. The Student's t test was used for statistics. Pregnancy, biochemical pregnancy, ectopic pregnancy, early clinical pregnancy loss, early pregnancy loss, and ongoing pregnancy rates. No significant differences were observed in any of the outcome parameters. Early pregnancy loss rates were similar: 23% in the OCP pretreatment group versus 19.2% in the non-OCP pretreatment group. However, longer periods of ovarian stimulation and higher doses of gonadotropins needed to be employed in the OCP group. There is not sufficient evidence to confirm OCP pretreatment as a risk factor for miscarriage in patients stimulated with GnRH antagonist protocols.

  3. Clinical outcome analysis of 98 elderly women with early-stage breast cancer undergoing modified radical mastectomy or simple mastectomy

    Institute of Scientific and Technical Information of China (English)

    Zhilong Jia; Baoxia Su

    2012-01-01

    Objective: The aim of our study was to analyze the clinical results and prognosis for early elderly patients after surgery and to explore the rational treatment. Methods: Between January 1992 and December 2008, 98 early elderly breast cancer patients aged ≥ 65 years were treated with surgery, of which 52 patients received modified radical mastectomy and 46 patients received simple mastectomy. Results: Sixty-four (65.3%) patients had comorbidities including coronary heart disease, hypertension, diabetes, etc. After a median follow up of 56 months (21 to 280 months), the 5-year cumulative survival rate of breast modified radical mastectomy group and mastectomy group were 84.0% and 82.7%, separately (P = 0.653). The 5-year recurrence rate were 3.8% and 8.1%, separately (P = 0.504). Conclusion: The simple mastectomy is suitable for the treatment of early elderly breast cancer patients for its lower complication and recurrence rate. Early old women with breast cancer may be safely treated by simple mastectomy. Our findings suggest that modified radical mastectomy does not significantly increase the overall survival.

  4. Early

    Directory of Open Access Journals (Sweden)

    Kamel Abd Elaziz Mohamed

    2014-04-01

    Conclusion: Early PDT is recommended for patients who require prolonged tracheal intubation in the ICU as outcomes like the duration of mechanical ventilation length of ICU stay and hospital stay were significantly shorter in early tracheostomy.

  5. Early-life factors and breast cancer risk in Hispanic women: the role of adolescent body size.

    Science.gov (United States)

    Sangaramoorthy, Meera; Phipps, Amanda I; Horn-Ross, Pamela L; Koo, Jocelyn; John, Esther M

    2011-12-01

    Adult body size has long been known to influence breast cancer risk, and there is now increasing evidence that childhood and adolescent body size may also play a role. We assessed the association with body size at ages 10, 15, and 20 years in 475 premenopausal and 775 postmenopausal Hispanic women who participated in a population-based case-control study of breast cancer conducted from 1995 to 2004 in the San Francisco Bay Area. We used unconditional logistic regression to estimate ORs and 95% CIs for the associations with self-reported relative weight compared with peers and body build at ages 10, 15, and 20 years. In premenopausal women, we found inverse associations with relative weight compared with peers, with ORs of 0.63 (P(trend) = 0.05), 0.31 (P(trend) Hispanics. Large body size at a young age may have a long-lasting influence on breast cancer risk in premenopausal, and possibly postmenopausal, Hispanic women that is independent of current body mass index. These findings need to be weighed against adverse health effects associated with early-life obesity.

  6. Pilot Study of an Individualised Early Postpartum Intervention to Increase Physical Activity in Women with Previous Gestational Diabetes

    Directory of Open Access Journals (Sweden)

    Harold David McIntyre

    2012-01-01

    Full Text Available Optimal strategies to prevent progression towards overt diabetes in women with recent gestational diabetes remain ill defined. We report a pilot study of a convenient, home based exercise program with telephone support, suited to the early post-partum period. Twenty eight women with recent gestational diabetes were enrolled at six weeks post-partum into a 12 week randomised controlled trial of Usual Care (n=13 versus Supported Care (individualised exercise program with regular telephone support; n=15. Baseline characteristics (Mean ± SD were: Age  33±4  years; Weight 80 ± 20 kg and Body Mass Index (BMI 30.0±9.7 kg/m2. The primary outcome, planned physical activity {Median (Range}, increased by 60 (0–540 mins/week in the SC group versus 0 (0–580 mins/week in the UC group (P=0.234. Walking was the predominant physical activity. Body weight, BMI, waist circumference, % body fat, fasting glucose and insulin did not change significantly over time in either group. This intervention designed to increase physical activity in post-partum women with previous gestational diabetes proved feasible. However, no measurable improvement in metabolic or biometric parameters was observed over a three month period.

  7. Surgical and oncological outcome of total laparoscopic radical hysterectomy in obese women with early-stage cervical cancer.

    Science.gov (United States)

    Moss, Esther Louise; Balega, Janos; Chan, Kiong K; Singh, Kavita

    2012-01-01

    To evaluate the clinical experience of the total laparoscopic radical hysterectomy (TLRH) for the surgical management of cervical cancer in obese (body mass index [BMI] >30 kg/m) and nonobese (BMI obese, BMI >30 kg/m, or nonobese, BMI hysterectomy cases performed before the introduction of the TLRH. A total of 58 women underwent a TLRH; 15 (25.9%) were obese and 43 (74.1%) were in the nonobese group. There was no significant difference in intraoperative blood loss or median duration of surgery between the obese and nonobese groups. The median hospital stay in both groups was 3 days (range, 2-13 days). Four cases were converted to laparotomy (7%); all were in the nonobese group. Postoperatively, 3 patients developed ischemic ureterovaginal fistulae (5%) between days 5 and 7 after surgery; all were in the nonobese group. There was no significant difference in the parametrial length, maximum vaginal cuff length, and number of lymph nodes excised between the 2 groups. To date, there has been one recurrence during the median follow-up period of 19 months (range, 3-42 months). She belonged to the nonobese group. The TLRH is a surgically safe procedure for early-stage cervical cancer. Obesity did not adversely affect the performance of TLRH or the radicality of the excision. In obese women, TLRH should be the favored route of surgery for all women who require a radical hysterectomy owing to its favorable perioperative outcome and short hospital stay.

  8. A generation apart? Gender-related experiences and health in women in early and late mid-life.

    Science.gov (United States)

    Hunt, Kate

    2002-03-01

    There have been a number of critiques in the last few years of the prevailing paradigm of research on gender and health, which dominated in the latter part of the 20th century. One such criticism has centred on the a historic and decontextualised way in which much evidence for gender differences has been used. In this paper we aim to show that, even within a relatively confined geographical locale over a relatively short period of time, there have been substantial changes in gender relations which are likely to have affected the experience, opportunities, and attitudes of women born in the early 1930s and early 1950s. We illustrate this using data from a study of inequalities in health in Scotland, which includes unusually rich longitudinal data on gender, including occupancy and experience of gender-related roles, attitudinal data on gender equality, and measures of gender role orientation (GRO). These are related to various dimensions of health and health behaviour. The data show substantial differences in the experiences of two generations of women, who are just 20 years apart in age, and a lack of consistency between measures of GRO and health. Whilst on the one hand these data suggest the importance of taking more account of the broader (social, historical or political) context, the analysis also highlights the methodological problems posed.

  9. Advantages of laparoscopy versus laparotomy in extremely obese women (BMI>35) with early-stage endometrial cancer: a multicenter study.

    Science.gov (United States)

    Tinelli, Raffaele; Litta, Pietro; Meir, Yoram; Surico, Daniela; Leo, Livio; Fusco, Annarita; Angioni, Stefano; Cicinelli, Ettore

    2014-05-01

    The aim of the present study was to demonstrate the advantages of laparoscopy versus laparotomy for treatment of extremely obese women with early-stage endometrial cancer. Seventy-five extremely obese patients with Body Mass Index >35 kg/m(2) and clinical stage I endometrial cancer underwent hysterectomy and bilateral salpingo-oophorectomy, and in all cases we performed systematic pelvic lymphadenectomy by laparoscopy (mean BMI of 38±7.3 kg/m(2)) or laparotomy (mean BMI of 39±8.1 kg/m(2)). In two (4.4%) patients of the laparoscopy group we observed a port site haematoma that was resolved without a second surgery. In three patients of the laparotomy-group, we observed dehiscence of the abdominal suture with surgical site infection that was re-sutured. Laparoscopy can be considered a safe and effective therapeutic procedure for managing early-stage endometrial cancer in extremely obese women with a lower complication rate, lower surgical site infection and postoperative hospitalization.

  10. Early diagnosis and treatment of genuine stress urinary incontinence in women after pregnancy: midwives as detectives.

    Science.gov (United States)

    Peeker, Iréne; Peeker, Ralph

    2003-01-01

    Genuine stress incontinence is often a hidden problem in that many women suffering from genuine stress incontinence after delivery do not seek medical advice. This article reviews signs and symptoms of genuine stress incontinence that, when identified, may enable midwives to initiate or suggest treatment as needed. A comprehensive literature search was performed in relevant medical databases. The following adverse risk factors for the development of genuine stress incontinence are vaginal delivery, multiparity, and obesity, with an increased risk for women who did not actively exert pelvic floor training. Prolonged second stage of labor and heavier babies were two factors associated with an increase in the risk of damage to the pelvic floor innervation as well as genuine stress incontinence. Several conservative treatment options, such as special instructions for pelvic floor training, the use of weight cones, and electrical stimulation, are reported to alleviate genuine stress incontinence symptoms.

  11. Skin wrinkles and rigidity in early postmenopausal women vary by race/ethnicity: baseline characteristics of the skin ancillary study of the KEEPS trial.

    Science.gov (United States)

    Wolff, Erin; Pal, Lubna; Altun, Tugba; Madankumar, Rajeevi; Freeman, Ruth; Amin, Hussein; Harman, Mitch; Santoro, Nanette; Taylor, Hugh S

    2011-02-01

    To characterize skin wrinkles and rigidity in recently menopausal women. Baseline assessment of participants before randomization to study drug. Multicenter trial, university medical centers. Recently menopausal participants enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Skin wrinkles were assessed at 11 locations on the face and neck using the Lemperle wrinkle scale. Skin rigidity was assessed at the forehead and cheek using a durometer. Skin wrinkles and rigidity were compared among race/ethnic groups. Skin wrinkles and rigidity were correlated with age, time since menopause, weight, and body mass index (BMI). In early menopausal women, wrinkles, but not skin rigidity, vary significantly among races, where black women have the lowest wrinkle scores. In white women, chronological age was significantly correlated with worsening skin wrinkles, but not with rigidity. Skin rigidity correlated with increasing length of time since menopause, however, only in the white subgroup. In the combined study group, increasing weight was associated with less skin wrinkling. Skin characteristics of recently menopausal women are not well studied. Ethnic differences in skin characteristics are widely accepted, but poorly described. In recently menopausal women not using hormone therapy (HT), significant racial differences in skin wrinkling and rigidity exist. Continued study of the KEEPS population will provide evidence of the effects of HT on the skin aging process in early menopausal women. Copyright © 2011 American Society for Reproductive Medicine. All rights reserved.

  12. Characteristics related to early secondary amenorrhoea and pregnancy among women diagnosed with systemic lupus erythematosus: an analysis using the GOAL study

    Science.gov (United States)

    Knight, Jessica H; Howards, Penelope P; Spencer, Jessica B; Tsagaris, Katina C; Lim, Sam S

    2016-01-01

    Objective Systemic lupus erythematosus (SLE) disproportionately affects women and often develops during their reproductive years. Research suggests that some women who receive cyclophosphamide as treatment for SLE experience earlier decline in menstrual function, but reproductive health among women with SLE who have not taken this drug is less well understood. This study aims to better understand the relation between SLE and reproduction by assessing early secondary amenorrhoea and pregnancy in women treated with and without cyclophosphamide from a population-based cohort with large numbers of African-Americans. Methods Female patients with SLE, ages 20–40 at time of diagnosis, who were 40 years or older at the time of the survey were included in this analysis (N=147). Participants in the Georgians Organized Against Lupus (GOAL) study were asked about their reproductive histories including early secondary amenorrhoea, defined as loss of menstruation before age 40. Results Women who were cyclophosphamide naïve had an increased prevalence of early secondary amenorrhoea compared with population estimates, 13–17% compared with 1–5%. Factors associated with early secondary amenorrhoea in women not treated with cyclophosphamide were marital status and receipt of a kidney transplant. Treatment with cyclophosphamide doubled the prevalence after adjustment for patient characteristics. Over 88% of women reported being pregnant at least once, and about 83% of these had a child, but the majority of pregnancies occurred before diagnosis. Conclusions SLE diagnosed in early adulthood may affect women's reproductive health even if they are not treated with cyclophosphamide. Better understanding of other factors related to reproductive health in this population will improve clinicians' and patients' abilities to make treatment and family planning decisions. PMID:27752335

  13. Facebook Advertisements for Inexpensive Participant Recruitment Among Women in Early Pregnancy.

    Science.gov (United States)

    Arcia, Adriana

    2014-06-01

    Facebook advertisements were used to recruit nulliparous women in the first 20 weeks of pregnancy for an online survey about their childbirth preferences. A campaign of ads was targeted to women, aged 18 to 44 years, residing in the United States. The ads were viewed 10,577,381 times by 7,248,985 unique Facebook users over 18 weeks in 2011. The ad campaign yielded 6,094 clicks by 5,963 unique users at a mean cost of $0.63 per click and a unique click-through rate of 0.08%. Of those who clicked through to the study site, 18% (n = 1,075) consented to participate. The participant pool was reduced to 344 women after application of strict eligibility criteria. Participants represented 43 states and the District of Columbia, their mean age was 20.9 years (Mdn = 19.0, SD = 4.0), and their mean weeks' gestation was 11.5 (SD = 5.8). The campaign cost was $3,821.81 or $11.11 per eligible participant.

  14. Psychosocial factors and mortality in women with early stage endometrial cancer.

    Science.gov (United States)

    Telepak, Laura C; Jensen, Sally E; Dodd, Stacy M; Morgan, Linda S; Pereira, Deidre B

    2014-11-01

    Psychosocial factors have previously been linked with survival and mortality in cancer populations. Little evidence is available about the relationship between these factors and outcomes in gynaecologic cancer populations, particularly endometrial cancer, the fourth most common cancer among women. This study examined the relationship between several psychosocial factors prior to surgical resection and risk of all-cause mortality in women with endometrial cancer. The study utilized a non-experimental, longitudinal design. Participants were 87 women (Mage  = 60.69 years, SDage  = 9.12 years) who were diagnosed with T1N0-T3N2 endometrial cancer and subsequently underwent surgery. Participants provided psychosocial data immediately prior to surgery. Survival statuses 4-5 years post-diagnoses were abstracted via medical record review. Cox regression was employed for the survival analysis. Of the 87 women in this sample, 21 women died during the 4- to 5-year follow-up. Adjusting for age, presence of regional disease and medical comorbidity severity (known biomedical prognostic factors), greater use of an active coping style prior to surgery was significantly associated with a lower probability of all-cause mortality, hazard ratio (HR) = 0.78, p = .04. Life stress, depressive symptoms, use of self-distraction coping, receipt of emotional support and endometrial cancer quality of life prior to surgery were not significantly associated with all-cause mortality 4-5 years following diagnosis. Greater use of active coping prior to surgery for suspected endometrial cancer is associated with lower probability of all-cause mortality 4-5 years post-surgery. Future research should attempt to replicate these relationships in a larger and more representative sample and examine potential behavioural and neuroendocrine/immune mediators of this relationship. What is already known on this subject? Psychosocial factors have previously been linked with clinical outcomes in a

  15. Work and Family Characteristics as Predictors of Early Retirement in Married Men and Women.

    Science.gov (United States)

    Kubicek, Bettina; Korunka, Christian; Hoonakker, Peter; Raymo, James M

    2010-01-01

    This study presents an integrative model of early retirement using data from the Wisconsin Longitudinal Study. The model extends prior work by incorporating work-family conflict to capture the interaction between the work and family domains and by assuming proximal and distal predictors of early retirement. More precisely, the model suggests that family and job demands and resources predict family-to-work and work-to-family conflict, respectively. All of these factors are presumed to have only indirect effects on retirement timing via the intervening effect of quality of life measures, that is, marital satisfaction, job satisfaction and health. The authors assume that these three factors constitute predictors of early retirement in addition to socioeconomic status and the availability of a pension plan and health insurance. The model was tested with structural equation modeling techniques, and the results were supportive. Therefore, the proposed model offers a general framework for the integration of previous research findings.

  16. Gender and Schooling in the Early Years. Research on Women and Education

    Science.gov (United States)

    Koch, Janice, Ed.; Irby, Beverly, Ed.

    2005-01-01

    In this volume, gender and schooling in the early years addresses a broad range of issues including, but not limited, to gender equity in education. We explore, for example, the complex world of play in Fromberg's chapter and are reminded that for young children, play involves issues of power and hierarchy in ways that parallel the role of gender…

  17. Broad and Narrow Personality Traits of Women's College Students in Relation to Early Departure from College

    Science.gov (United States)

    Taylor, Sarah E.; Scepansky, James A.; Lounsbury, John W.; Gibson, Lucy W.

    2010-01-01

    Personality traits of coeducational students have been shown to correlate with early withdrawal intention from college (Lounsbury, Saudargas, & Gibson, 2004). The current study investigated the relationship between the Big Five personality traits as well as seven narrow personality traits in relation to withdrawal intention among 103 female…

  18. Baseline demographic, anthropometric, psychosocial, and behavioral characteristics of rural, Southern women in early pregnacy

    Science.gov (United States)

    Beginning life in a healthy uterine environment is essential for future well-being, particularly as it relates to chronic disease risk. Baseline (early pregnancy) demographic, anthropometric (height and weight), psychosocial (depression and perceived stress), and behavioral (diet and exercise) char...

  19. Maternal and Early Childhood Determinants of Women's Body Size in Midlife : Overall Cohort and Sibling Analyses

    NARCIS (Netherlands)

    Ester, Wietske A.; Houghton, Lauren C.; Lumey, L. H.; Michels, Karin B.; Hoek, Hans W.; Wei, Ying; Susser, Ezra S.; Cohn, Barbara A.; Terry, Mary Beth

    2017-01-01

    Observational evidence suggests that adult body size has its roots earlier in life, yet few life-course studies have data on siblings with which to control for family-level confounding. Using prospective data from the Early Determinants of Mammographic Density Study (n = 1,108; 1959-2008), we examin

  20. The antecedents of women's external locus of control: Associations with characteristics of their parents and their early childhood.

    Science.gov (United States)

    Golding, Jean; Gregory, Steven; Iles-Caven, Yasmin; Nowicki, Stephen

    2017-01-01

    Locus of control (LOC) measures individuals' expectancies regarding their ability to affect what happens to them based on how they behave. The more they believe their behaviour has something to do with what happens to them the more internal they are. In contrast the more they perceive that what happens to them is beyond their control and determined by luck, fate, chance or powerful others the more external they are. Copious research findings suggest that external LOC (ELOC) is associated with many adverse personal, social, academic and health outcomes. In spite of its importance in so many areas of human behaviour relatively little is known about the features of the early background of individuals that contributes to these expectancies. This is the first in a number of studies that will suggest possible antecedents and consequences of having a high ELOC. The study takes advantage of the data collected in the Avon Longitudinal Study of Parents and Children (ALSPAC), which started by studying pregnancies in 1991-1992 of residents in an area of south-west England. Over 12000 of the women who enrolled during pregnancy completed a set of questions in mid-pregnancy from which an LOC score was computed. ELOC was defined as a score greater than the median. The relationships with characteristics of the women's parents and her early childhood (<6 years) are considered first as unadjusted odds ratios and then as adjusted after analysis using hierarchical sets of stepwise logistic regressions. The relative contributions to the women's ELOC was measured using a goodness-of-fit (GOF) measure. The analyses demonstrated the independent importance of maternal and paternal backgrounds as well as features of her early childhood (<6 years). The final model identified nine independent features (each with P < 0.0001): year of birth of her mother, maternal and paternal education levels, father smoked, mother smoked when pregnant, year of birth of study woman, the number of older siblings

  1. Predictors of first lifetime episodes of major depression in midlife women.

    Science.gov (United States)

    Bromberger, J T; Kravitz, H M; Matthews, K; Youk, A; Brown, C; Feng, W

    2009-01-01

    Little is known about factors that predict first lifetime episodes of major depression in middle-aged women. It is not known whether health-related factors and life stress pose more or less of a risk to the onset of clinical depression than does the menopausal transition. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) was used to assess diagnoses of lifetime, annual and current major depression in a community-based sample of premenopausal or early perimenopausal African American and White women. Menstrual cycle characteristics, psychosocial and health-related factors, and blood samples for assay of reproductive hormones were obtained annually. Two hundred and sixty-six women without a history of major depression at baseline constituted the cohort for the current analyses. Over 7 years of follow-up, 42 (15.8%) women met criteria for a diagnosis of major depression. Frequent vasomotor symptoms (VMS; hot flashes and/or night sweats) (HR 2.14, p=0.03) were a significant predictor of major depression in univariate analyses. After simultaneous adjustment for multiple predictors in Cox proportional hazards analyses, frequent VMS were no longer significant; lifetime history of an anxiety disorder (HR 2.20, p=0.02) and role limitations due to physical health (HR 1.88, p=0.07) at baseline and a very stressful life event (HR 2.25, p=0.04) prior to depression onset predicted a first episode of major depression. Both earlier (e.g. history of anxiety disorders) and more proximal factors (e.g. life stress) may be more important than VMS in contributing to a first episode of major depression during midlife.

  2. 自拟温肾逍遥汤治疗围绝经期干眼症的疗效观察%Clinical observation of Warming Kidney Xiaoyao Decoction on perimenopausal dry eye syndrome

    Institute of Scientific and Technical Information of China (English)

    尹连荣; 高健生

    2011-01-01

    目的 探讨自拟温肾逍遥汤治疗围绝经期干眼症患者的临床疗效.方法 收集高健生主任医师2009年2月至2010年4月门诊治疗的围绝经期干眼症患者31例(56只眼),予口服温肾逍遥汤5周,局部不用药物.分别记录治疗前和治疗5周患者的自觉症状积分、泪膜破裂时间(breakup time of tear film,BUT)、泪液分泌试验(Schirmer Ⅰ test,SⅠt)数值.结果 56只眼中44只眼(23例)治愈(78.57%);5只眼(3例)好转(8.93%);7只眼(5例)全身症状改善,眼部症状改善不明显(12.50%),总有效率为87.50%.服药后患者自觉症状积分减少,BUT、SIt值增加,治疗前后各指标比较差异均有统计学意义(P<0.05).结论 温肾逍遥汤不仅能够明显改善围绝经期女性的干眼症自觉症状,还可以明显改善患者的泪液分泌,延长泪膜破裂时间,具有良好的临床疗效.%OBJECTIVE To explore the clinical effect of Warming Kidney Xiaoyao Decoction (WKXD) for perimenopausal dry eye syndrome. METHODS In the retrospective clinic trial, 31 perimenopausal women (56 eyes) with dry eye symptoms were treated with WKXD between February 2009 and April 2010. Subjective symptom scores, tear film break-up time and Schirmer I test scores were recorded before treatment and 5 weeks after treatment respectively, which were analysed by paired t-test. RESULTS After treatment, 44 out of 56 eyes (78.57%) were cured; 5 out of 56 eyes (8.93%) were improved; 7 out of 56 eyes were not improved on eye symptoms but were improved on systemic symptoms. The effective rate was 87.5% on eye symptoms and 100% on the systemic symptoms. The statistical analysis showed significant difference between before treatment and treatment after 5 weeks on subjective symptom scores, tear film break-up time and Schirmer I test scores. CONCLUSIONS Warming Kidney Xiaoyao Decoction was effective in treating dry eye symptoms of perimenopausal women.

  3. Reproductive and lifestyle factors associated with early menopause in Mexican women Factores reproductivos y de estilos de vida asociados con menopausia temprana en mujeres mexicanas

    OpenAIRE

    Paola A. Ortega-Ceballos; Carlos Morán; Julia Blanco-Muñoz; Elsa Yunes-Díaz; Maura S. Castañeda-Iñiguez; Jorge Salmerón

    2006-01-01

    OBJECTIVE: The purpose of this study was to evaluate the relationship between certain reproductive and lifestyle factors and the occurrence of early natural menopause. MATERIAL AND METHODS: A case/control study was conducted on a basal population of 2 510 women participating in the "Mexican Institute of Social Security health workers cohort study". Cases were defined as those women for whom natural menopause presented by age 47. Information was obtained through a self-administered questionnai...

  4. Improvement Effect of Kunbao Pill on Perimenopausal Sleep Disorder%坤宝丸对围绝经期睡眠障碍的改善作用

    Institute of Scientific and Technical Information of China (English)

    郑志凌

    2015-01-01

    Objective To investigate the effect of Kunbao Pills for improving sleep disorder in perimenopausal women. Methods Totally 118 patients with perimenopausal sleep disorder were randomly divided into the control group and the observation group,59 cases in each group. The control group was treated by Oryzanol Tablets combined with Estradiol Valerate Tablets,while the observation group was treated by Kunbao Pill. The treatment course for both groups lasted for 3 months. The total effective rate,improvement degree of Pitts-burph sleep quality index(PSQI)score and the changes of estradiol(E2),luteinizing hormone(LH)and follicle stimulating hormone(FSH) were observed and compared between the two groups. At the same time the occurrence rates of adverse drug reactions during the treat-ment process were also compared. Results The total effective rate had no statistically significant difference between the two groups (72. 88% vs 77. 97%,P ﹥ 0. 05). The PSQI scores after treatment in the two groups were decreased significantly compared with before treatment( P ﹤ 0. 05),but the descend degree in the observation group was more obvious than that in the control group( P ﹤ 0. 05). The related hormone levels of E2,LH and FSH after treatment in the two groups were significantly improved compared with before treatment( P ﹤ 00. 05),but the differences after treatment between the two groups had no statistical significance( P ﹥ 0. 05). The occur-rence rate of adverse reactions in control group was significantly higher than that in the observation group(10. 17% vs 3. 39%,P ﹤0. 05). Conclusion Kunbao Pills has definite effect for improving perimenopausal sleep disorder,moreover has better safety than the traditional hormone replacement therapy.%目的:探讨坤宝丸对围绝经期妇女睡眠障碍的改善作用。方法将118例围绝经期睡眠障碍患者随机分为对照组和观察组,各59例。对照组患者采用戊酸雌二醇片联合谷维

  5. Blood pressure analysis among pregnant women for an early diagnosis of gestational hypertensive syndrome

    Directory of Open Access Journals (Sweden)

    Andreza de Sá Gomes

    2013-12-01

    Full Text Available The objective was to compare the blood pressure (BP levels of pregnant women, measured in a preparation room of a Family Health Center and verified in the consultation room following the Brazilian Guidelines for Hypertension. This comparative and quantitative study was performed with 94 pregnant women. Data collection was conducted between September and November of 2011 in two phases: the first consisted of collecting BP measurements by the preparation room staff, and observing the technique used for the measurement. The second phase occurred in the consultation room, when the BP was measured once again, following the 6th Brazilian Guidelines for Hypertension. Differences were observed in 87% of the measurements, ranging from - 38 to 28mmHg for systolic BP and – from 26 to 20mmHg for diastolic BP. It is concluded that a significant difference exists between the BP measurements taken in the preparation room and those taken in the consultation room. Descriptors: Hypertension, Pregnancy-Induced; Arterial Pressure; Prenatal Care; Primary Health Care; Nursing Care.

  6. Advanced Imaging and Receipt of Guideline Concordant Care in Women with Early Stage Breast Cancer

    Directory of Open Access Journals (Sweden)

    Elizabeth Trice Loggers

    2016-01-01

    Full Text Available Objective. It is unknown whether advanced imaging (AI is associated with higher quality breast cancer (BC care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washington State. We examined receipt of preoperative breast magnetic resonance imaging (MRI or AI (defined as computed tomography [CT]/positron emission tomography [PET]/PET/CT versus mammogram and/or ultrasound (M-US alone and receipt of guideline concordant care (GCC using multivariable logistic regression. Results. Of 5247 women, 67% received M-US, 23% MRI, 8% CT, and 3% PET/PET-CT. In 2002, 5% received MRI and 5% AI compared to 45% and 12%, respectively, in 2008. 79% received GCC, but GCC declined over time and was associated with younger age, urban residence, less comorbidity, shorter time from diagnosis to surgery, and earlier year of diagnosis. Breast MRI was associated with GCC for lumpectomy plus radiation therapy (RT (OR 1.55, 95% CI 1.08–2.26, and p=0.02 and AI was associated with GCC for adjuvant chemotherapy for estrogen-receptor positive (ER+ BC (OR 1.74, 95% CI 1.17–2.59, and p=0.01. Conclusion. GCC was associated with prior receipt of breast MRI and AI for lumpectomy plus RT and adjuvant chemotherapy for ER+ BC, respectively.

  7. Pattern of thyroid function during early pregnancy in women diagnosed with subclinical hypothyroidism and treated with l-thyroxine is similar to that in euthyroid controls.

    Science.gov (United States)

    De Geyter, Christian; Steimann, Sabine; Müller, Beat; Kränzlin, Marius E; Meier, Christian

    2009-01-01

    Subclinical hypothyroidism (SCH) is associated with a higher miscarriage rate. It is unclear how the thyroid function in SCH differs from that in euthyroidism during early pregnancy. We intended to determine the regulation of thyroid function in women with SCH receiving constant l-thyroxine (T4) replacement during early pregnancy as compared to euthyroid controls. This was a prospective cohort study with weekly serum sampling in eight women in early pregnancy with SCH and eight euthyroid women from week 5 to week 12 of pregnancy. Thyroid function was assessed before pregnancy. Women with SCH were treated with T4 (50 microg daily) and continued on an unchanged dose until week 12. The following parameters were measured weekly: thyrotropin (TSH), thyroglobulin, thyroxine, triiodothyronine, free thyroxine (FT4), free triiodothyronine (FT3), estradiol, progesterone, human chorionic gonadotropin, and prolactin. Although the pregestational levels of TSH were significantly higher among women with SCH as compared to euthyroid controls, the self-limited estrogen-induced increment of TSH during early pregnancy was similar in both groups. Although both SCH and ovarian hyperstimulation were associated with an intermediate rise in TSH, the pattern of thyroid function followed similar changes as in euthyroid controls and is unlikely to cause the higher miscarriage rate observed in SCH.

  8. Hispanic women's experience with "el cambio de vida".

    Science.gov (United States)

    Longworth, Judith C

    2003-06-01

    To examine the factors that influence Hispanic women's decisions to initiate or not initiate hormone replacement therapy (HRT) during menopause to manage symptoms or to prevent longer-term conditions. A descriptive study of 51 Hispanic women who completed the Spanish version of the Menopausal Decision-Making Questionnaire (S-MDMQ) to describe their experience with and perceptions about menopause. Most of the low-income Hispanic women in this study would elect not to take HRT; however, they do use exercise, diet, vitamins, and other self-care activities to manage symptoms of menopause. Hispanic women were eager to discuss how to manage their health care during perimenopause and menopause with one another and their health care providers. Nurse practitioners need to understand factors that might influence Hispanic women's decisions regarding management of menopausal symptoms, including the use of HRT, and to be able to assist women in making an individualized personal treatment choice that is culturally acceptable.

  9. Diagnostic test of endometrial cytobrush in cases of perimenopausal and postmenopausal hemorrhage

    Directory of Open Access Journals (Sweden)

    Andrijono Andrijono

    2005-06-01

    Full Text Available Perimenopausal menopausal hemorrhage can be due to by a variety of causative factors. One of its dangerous causes is atypical hyperplasia and endometrial carcinoma. There are a number of risk factors for the occurrence of endometrial carcinoma. The group that has this risk belongs to high-risk group. In this high-risk group, it is necessary to have a method to identify the changes in endometrial abnormality. One of the alternatives is the examination of endometrial cytology. The objective of this study was to evaluate the sensitivity, specificity and correlation test between endometrial cytology and endometrial histology. This study was a diagnostic test of cytological examination of the endometrium as compared with endometrial histology. Endometrial cytology was performed with a modification of cytubrush and IUD shell. Specimen was dissolved into the centrifuged NaCl, and its deposits were then processed for cytological examination with Papanicolaou and Giemsa staining. After the taking of cytology, the process was continued with curettage of the endometrium, and the specimens were processed for cytological examination. Both of them were examined by anatomic pathologist. Statistical analysis used diagnostic test using histological examination of curetage specimens as gold standard. During the period of study 45 study samples were collected, among which 12 (26.66% were endometrial adenocarcinoma, 6 (13.33% with atypical hyperplasia, 11 (24.44% with non-atypical hyperplasia, 15 (33.33% were samples without abnormality, and one sample with endometritis. Actual correlation value was 57.8%, correlation because of possibility 3.38%, and correlation not because of possibility 54.42%, potential correlation not because of possibility 96.62%, and Kappa value 0.56. It was concluded that cytological examination of the endometriurn with cytobrush could be employed as a screening method in the abnormalities of endometrial thickness, with

  10. Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women

    Directory of Open Access Journals (Sweden)

    Sharath Gangadhara

    2009-04-01

    Full Text Available Sharath Gangadhara, Gianfilippo BertelliSouth West Wales Cancer Institute, Singleton Hospital, Swansea, UKAbstract: For more than 20 years, tamoxifen has been the gold standard for the adjuvant treatment of postmenopausal women with hormone-responsive early breast cancer. However, recent randomized trials have shown efficacy and tolerability benefits with the third-generation aromatase inhibitor anastrozole, resulting in an increased use of this agent in the adjuvant setting. Data on anastrozole’s long-term efficacy and tolerability are therefore of interest in clinical practice and will be reviewed here, especially in the light of the 100-month analysis of the ATAC (Anastrozole, Tamoxifen Alone or in Combination trial.Keywords: anastrozole, aromatase inhibitors, breast cancer, adjuvant therapy 

  11. Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography

    DEFF Research Database (Denmark)

    Lyng, Maria B; Kodahl, Annette R; Binder, Harald;

    2016-01-01

    is significantly different between women with breast cancer and controls (p-value woman whose 9-miRNA profile predicted a 73% probability of having breast cancer indeed developed the disease within one year despite being categorized as clinically healthy...... developed a 9-miRNA profile using serum and LNA-based qPCR that effectively stratified patients with early stage breast cancer vs. healthy women. To further develop the test into routine clinical practice, we collected serum of women examined by clinical mammography (N = 197) according to standard...

  12. Group B streptococcal immunisation of pregnant women for the prevention of early and late onset Group B streptococcal infection of the neonate as well as adult disease

    DEFF Research Database (Denmark)

    Kenchington, Anna L.; Lamont, Ronald F.

    2017-01-01

    or in the future, vaccination. Areas covered: The introduction of a vaccine to women in the third trimester is likely to further reduce the burden of disease and provide benefits beyond the prevention of early neonatal disease, including meningitis and disability following late onset disease. Development......Introduction: Early onset neonatal Group B streptococcal disease is preventable. Intrapartum antibiotic prophylaxis has resulted in a significant reduction in neonatal mortality and morbidity. National guidelines for the selection of women eligible for intrapartum antibiotic prophylaxis, whether...

  13. Food matrix and isoflavones bioavailability in early post menopausal women: An European clinical study

    Directory of Open Access Journals (Sweden)

    Brigitte Chanteranne

    2008-12-01

    Full Text Available Brigitte Chanteranne1,2, Francesco Branca3, A Kaardinal4, K Wahala5, Véronique Braesco6, Philippe Ladroite7, Fred Brouns8, Véronique Coxam1,21INRA, Centre Clermont-Ferrand – Theix, UMR1019, Unité Nutrition Humaine, St Genès Champanelle, France; 2Univ Clermont 1, UFR Médecine, UMR1019, Unité Nutrition Humaine, Clermont-Ferrand, France; 3INRAN, Human Nutrition Unit, Ardeatina, Rome, Italy; 4TNO Nutrition and Food Research, Zeist, The Netherlands; 5Department of Chemistry, University of Helsinki, Helsinki, Finland; 6Danone Vitapole, Le Plessis Robinson, France; 7Nutrition Santé, Ravel, France; 8Eridania Beghin Say, Vilvoorde Research and Development Centre, Vilvoorde, BelgiumAbstract: The estrogenic effects of soy isoflavones (IF on symptoms of menopause are of particular interest. The aim of the present study was to improve compliance of IF in two IF-enriched foods providing the same IF circulating levels in postmenopausal women. Forty-two healthy postmenopausal women (mean age: 53.28 years were recruited for a randomized, crossover, multicenter trial conducted in the Netherlands, Italy and France. Over 18 days, volunteers were assigned to two groups and supplemented with two different IF-enriched foods (100 mg IF aglycones/two servings. The first group had to eat two biscuits daily for three days. After a wash-out period (11 d, they received cereal bars for three days. The second group started with the cereal bars and finished with biscuits. After IF intake, plasma and urinary levels of genistein, daidzein, O desmethyl angolensin and equol significantly increased and returned to baseline level after the washout period. There was no difference between biscuits and cereals bars intake, as shown by group values at each end of experimental period (day 4 or day 18. Both matrixes are comparable in terms of IF-circulating levels and could be used independently.Keywords: soy isoflavones, bioavailability, food processing, postmenopausal women

  14. Relation of statin use and bone loss: a prospective population-based cohort study in early postmenopausal women.

    Science.gov (United States)

    Sirola, J; Sirola, J; Honkanen, R; Kröger, H; Jurvelin, J S; Mäenpää, P; Saarikoski, S

    2002-07-01

    Recent experimental and epidemiologic studies have suggested that the lipid-lowering drugs, statins, may have bone-protective effects. We studied the effects of statin use on the change in bone mineral density (BMD) in a prospective 4.5-year cohort study based on subjects from the Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study, Finland. Six hundred and twenty women aged 53-64 years were divided into four groups: 55 women reported continuous and 63 women occasional statin use during the follow-up; 142 non-users of statins reported hypercholesterolemia whereas 360 non-users did not. Spinal and femoral BMDs were measured by dual-energy X-ray densitometry in 1995-1996 and 1999-2000 and the BMD changes of the four groups were compared. Characteristics of the study population were obtained with postal inquiries. The mean annual spinal and femoral BMD changes of the study groups were 0.29% and -0.50% for the continuous statin users, 0.19% and -0.57% for the occasional statin users, 0.52% and -0.29% for the hypercholesterolemic non-users of statins, and 0.39% and -0.33% for the non-users of statins without hypercholesterolemia, ( p = 0.398 and p = 0.404) respectively. The corresponding BMD changes adjusted for age, years since menopause, body mass index, BMD at baseline, calcium intake, estrogen and cortisone therapy, duration of follow-up and statin use before the baseline were -0.20% and -0.47%, 0.19% and -0.54%, 0.54% and -0.32%, 0.47% and -0.33% ( p = 0.134 and p = 0.628), respectively. Our results suggest that statins do not protect from early postmenopausal bone loss. Randomized trials are needed to confirm these results.

  15. Progesterone and Bone: Actions Promoting Bone Health in Women

    Directory of Open Access Journals (Sweden)

    Vanadin Seifert-Klauss

    2010-01-01

    Full Text Available Estradiol (E2 and progesterone (P4 collaborate within bone remodelling on resorption (E2 and formation (P4. We integrate evidence that P4 may prevent and, with antiresorptives, treat women's osteoporosis. P4 stimulates osteoblast differentiation in vitro. Menarche (E2 and onset of ovulation (P4 both contribute to peak BMD. Meta-analysis of 5 studies confirms that regularly cycling premenopausal women lose bone mineral density (BMD related to subclinical ovulatory disturbances (SODs. Cyclic progestin prevents bone loss in healthy premenopausal women with amenorrhea or SOD. BMD loss is more rapid in perimenopause than postmenopause—decreased bone formation due to P4 deficiency contributes. In 4 placebo-controlled RCTs, BMD loss is not prevented by P4 in postmenopausal women with increased bone turnover. However, 5 studies of E2-MPA co-therapy show greater BMD increases versus E2 alone. P4 fracture data are lacking. P4 prevents bone loss in pre- and possibly perimenopausal women; progesterone co-therapy with antiresorptives may increase bone formation and BMD.

  16. Early Vascular Damage in Young Women with DM-1 and Its Relation to Anti-Müllerian Hormone: A Cross-Sectional Study

    Directory of Open Access Journals (Sweden)

    Annelien C. de Kat

    2016-01-01

    Full Text Available Vascular function is suggested to be associated with ovarian reserve, but the relationship with microvascular function has never been studied. In this cross-sectional pilot study, the relationship of microvascular damage markers with AMH was studied in premenopausal women. Twenty-two regularly cycling women with type 1 diabetes (DM-1 and a reference group of 20 healthy regularly cycling women were included, from whom blood was drawn in the early follicular phase of the menstrual cycle. The main outcome was the correlation between circulating progenitor cells (CPCs, markers for early vascular damage, and AMH, a marker for ovarian reserve. Secondary endpoints for early vascular impairment were circulating angiogenic cells and additional biomarkers. Median AMH levels were 2.2 µg/L [1.2–3.5] in the DM-1 group and 2.1 µg/L [0.85–3.8] in the reference group. CPCs were significantly decreased in women with DM-1; 1204±537 CD34+/CD45dim cells were counted in the DM-1 group, compared to 2264±1124 in the reference group. CPCs and other markers of early vascular damage were not correlated with AMH levels in a multivariable analysis. These results underscore previous findings of early vascular damage in DM-1 and suggest that there may not be a relationship between vascular function and ovarian reserve. Trial Registration. This trial is registered with Clinicaltrials.gov NCT01665716.

  17. Plasma oxidative stress parameters in men and women with early stage Alzheimer type dementia.

    Science.gov (United States)

    Puertas, M C; Martínez-Martos, J M; Cobo, M P; Carrera, M P; Mayas, M D; Ramírez-Expósito, M J

    2012-08-01

    It is well known that oxidative stress is one of the earliest events in Alzheimer's disease pathogenesis, indicating that may play a key role in this disease. In our study, we measured the levels of oxidative stress indicators (TBARS and protein carbonyls content) and the non-enzymatic (glutathione (GSH) and oxidized glutathione (GSSG)) and enzymatic (glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD)) defense systems in the plasma of 46 patients diagnosed of ATD and 46 age-matched controls. We found decreased levels in total GSH in ATD patients, although healthy control women showed lower levels of total GSH than healthy control men. On the contrary, we found increased levels of TBARS and carbonyl groups content in ATD patients in both genders. The activity of the plasma antioxidant enzymes showed no changes for SOD activity in ATD patients, independently of the gender, although western blot analysis showed an increase in SOD-1 protein. CAT activity was also decreased in ATD patients, although this decrease is mainly due to the decrease found in men but not in women. However, western blot analysis did not show differences in CAT protein between controls and ATD patients. Finally, a decrease of GPx activity was found in ATD patients in both genders. However, as with CAT protein, western blot analysis did not show differences in GPx protein between controls and ATD patients. Our results suggest that there is a defect in the antioxidant defense system that is incapable of responding to increased free radical production, which may lead to oxidative damage and the development of the pathological alterations that characterize the neurodegenerative disorder of patients with ATD. Thus, oxidative damage could be one important aspect for the onset of ATD and oxidative stress markers could be useful to diagnose the illness in their earliest stages through both non-invasive, reliable and cost-affordable methods.

  18. 血清性激素、血脂水平与围绝经期症状的相关性探讨%Exploration of the correlation of serum sex hormone, blood lipid level and the symptoms of peri-menopause

    Institute of Scientific and Technical Information of China (English)

    陈怡红; 李海文; 沙伟玲; 肖纬红; 罗翠连

    2016-01-01

    Objective:To explore the correlation of serum sex hormone, blood lipid level and the symptoms of peri-menopause. Methods: 250 female cases were selected as research objects and divided into four groups: The childbearing age control group (n=60), peri menopause group (n=60), early menopause group (n=65) and post menopause group (n=65), Testosterone (T), serum estradiol (E2), triglyceride (TG), follicle stimulating hormone (FSH), and total cholesterol (TC) detection were made respectively and menopausal index (KMI) was investigated, the detection results of four groups were compared and the correlation was analyzed. Results:Compared with the childbearing age control group, the T and E2 level of peri menopause group, early menopause group and post menopause group decreased significantly while FSH level increased significantly, the difference was statistically significant (P<0.05); the TG and TC level of peri menopause group, early menopause group and post menopause group increased significantly, the difference was statistically significant (P<0.05); meanwhile, TC was positively related to KMI while TG was negatively related to KMI. Conclusion:Testosterone and estradiol decreased significantly in post menopause women while the follicle stimulating hormone increased significantly, serum estradiol was negatively related to KMI, therefore, strengthening the monitoring of the blood lipid level and serum sex hormone levels in the peri menopausal women helped to relieve the menopausal symptoms and improve the quality of women life.%目的:探析围绝经期症状与血脂水平、血清性激素之间的相关性。方法:选择250例女性为研究对象,将其分为四组,分别是育龄对照组(n=60)、围绝经期组(n=60)、绝经早期组(n=65)及绝经晚期组(n=65),分别对其进行睾酮(T)、血清雌二醇(E2)、三酰甘油(TG)、卵泡刺激素(FSH)以及总胆固醇(TC)测定,调查绝经指数(KMI),比

  19. Cervical cancer screening of underserved women in the United States: results from the National Breast and Cervical Cancer Early Detection Program, 1997-2012.

    Science.gov (United States)

    Tangka, Florence K L; Howard, David H; Royalty, Janet; Dalzell, Lucinda P; Miller, Jacqueline; O'Hara, Brett J; Sabatino, Susan A; Joseph, Kristy; Kenney, Kristy; Guy, Gery P; Hall, Ingrid J

    2015-05-01

    The National Breast and Cervical Cancer Early Detection Program (NBCCEDP) provides breast and cervical cancer screens to low-income, uninsured, and underinsured women. We describe the number and proportion of women eligible for cervical cancer screening services and the proportion of eligible women screened over the period 1997-2012. Low-income, uninsured, and underinsured women aged 18-64 years who have not had a hysterectomy are eligible for cervical cancer screening through the NBCCEDP. We estimated the number of low-income, uninsured women using data from the US Census Bureau. We adjusted our estimates for hysterectomy status using the National Health Interview Survey and the Behavioral Risk Factor Surveillance System. We used data from the NBCCEDP to describe the number of women receiving NBCCEDP-funded screening and calculated the proportion of eligible women who received screening through the NBCCEDP at the national level (by age group, race/ethnicity) and at the state level by age group. We used the Medical Expenditure Panel Survey to estimate the proportion of NBCCEDP-eligible women who were screened outside the NBCCEDP and the proportion that are not screened. We estimate that in 2010-2012, 705,970 women aged 18-64 years, 6.5 % (705,970 of 9.8 million) of the eligible population, received NBCCEDP-funded Pap tests. We estimate that 60.2 % of eligible women aged 18-64 years were screened outside the NBCCEDP and 33.3 % were not screened. The NBCCEDP provided 623,603 screens to women aged 40-64 years, an estimated 16.5 % of the eligible population, and 83,660 screens to women aged 18-39 years, representing an estimated 1.2 % of the eligible population. The estimated proportions of eligible women screened in each state ranged from 1.5 to 32.7 % and 5 % to 73.2 % among the 18-64 and 40-64 years age groups, respectively. Changes in the proportion of eligible women screened over the study period were nonsignificant. Although the program provided cervical

  20. 沧州地区围绝经期女性性功能障碍发生率及影响因素调查研究%Theprevalence of perimenopausal sexual function disorders in Cangzhou and its influencing factors

    Institute of Scientific and Technical Information of China (English)

    魏振杰; 孙金豹

    2015-01-01

    Objectives:To analyze the prevalence and types of perimenopausal sexual function disorders in Cangzhou and its influencing factors.Methods:Female Sexual Function Index (FSFI)and the Self -Rating De-pression Scale (SDS)were used to survey the perimenopausal women in Cangzhou randomly.The survey results were recorded and its influencing factors were discussed.Results:230 of the 300 questionnaires collected were ef-fective.Factors affecting female perimenopausal sexual dysfunction mainly included age,hormonal supplements and depression factors,the first two of which were significantly different (P 0.05);while SDS score ≥53 points,difference in the proportion of people with sexual dysfunction was statis-tically significant (P <0.05);for perimenopausal women of different ages,the six dimension scores of sexual desire disorder,sexual arousal disorder,vaginal lubrication,orgasm,sexual satisfaction,and sexual pain disorders were with significant differences (P <0.05);of the 230 women surveyed,156 cases suffered from FSD,a proportion of 67.8%.The proportion of people suffering from sexual desire disorder,sexual arousal disorder,vaginal lubrication, orgasm,sexual satisfaction proportion obstacles were 80.1%,70.5%,78.2%,65.4%,62.8% and 67.9% re-spectively.Conclusions:The factors affecting sexual dysfunction in postmenopausal women mainly include age, supplemental hormones and depression factors.Taking results of FSFI for reference,67.8% women suffer from FSD,and the prevalence of each dimension decreases in the order of sexual desire disorder,vaginal lubrication, sexual arousal disorder,orgasmic disorder and sexual satisfaction obstacles.%目的:分析研究沧州地区围绝经期女性性功能障碍患病率及患病类型,分析影响围绝经期女性性功能障碍的因素。方法:采用随机选择的方法,使用女性性功能指数量表(Female Sexual Function In-dex,FSFI)和抑郁自评量表(Self -rating depression scale,SDS)对沧州

  1. Similar Survival With Breast Conservation Therapy or Mastectomy in the Management of Young Women With Early-Stage Breast Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Mahmood, Usama, E-mail: usama.mahmood@gmail.com [Department of Radiation Oncology, University of Maryland, Baltimore, Maryland (United States); Morris, Christopher; Neuner, Geoffrey [Department of Radiation Oncology, University of Maryland, Baltimore, Maryland (United States); Koshy, Matthew [Department of Cellular and Radiation Oncology, University of Chicago, Chicago, Illinois (United States); Kesmodel, Susan; Buras, Robert [Department of Surgery, University of Maryland, Baltimore, Maryland (United States); Chumsri, Saranya; Bao Ting; Tkaczuk, Katherine [Department of Medicine, University of Maryland, Baltimore, Maryland (United States); Feigenberg, Steven [Department of Radiation Oncology, University of Maryland, Baltimore, Maryland (United States)

    2012-08-01

    Purpose: To evaluate survival outcomes of young women with early-stage breast cancer treated with breast conservation therapy (BCT) or mastectomy, using a large, population-based database. Methods and Materials: Using the Surveillance, Epidemiology, and End Results (SEER) database, information was obtained for all female patients, ages 20 to 39 years old, diagnosed with T1-2 N0-1 M0 breast cancer between 1990 and 2007, who underwent either BCT (lumpectomy and radiation treatment) or mastectomy. Multivariable and matched pair analyses were performed to compare overall survival (OS) and cause-specific survival (CSS) of patients undergoing BCT and mastectomy. Results: A total of 14,764 women were identified, of whom 45% received BCT and 55% received mastectomy. Median follow-up was 5.7 years (range, 0.5-17.9 years). After we accounted for all patient and tumor characteristics, multivariable analysis found that BCT resulted in OS (hazard ratio [HR], 0.93; 95% confidence interval [CI], 0.83-1.04; p = 0.16) and CSS (HR, 0.93; CI, 0.83-1.05; p = 0.26) similar to that of mastectomy. Matched pair analysis, including 4,644 BCT and mastectomy patients, confirmed no difference in OS or CSS: the 5-, 10-, and15-year OS rates for BCT and mastectomy were 92.5%, 83.5%, and 77.0% and 91.9%, 83.6%, and 79.1%, respectively (p = 0.99), and the 5-, 10-, and 15-year CSS rates for BCT and mastectomy were 93.3%, 85.5%, and 79.9% and 92.5%, 85.5%, and 81.9%, respectively (p = 0.88). Conclusions: Our analysis of this population-based database suggests that young women with early-stage breast cancer have similar survival rates whether treated with BCT or mastectomy. These patients should be counseled appropriately regarding their treatment options and should not choose a mastectomy based on the assumption of improved survival.

  2. A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats.

    Directory of Open Access Journals (Sweden)

    Jun Ming Wang

    Full Text Available The molecular mechanisms for the discrepancy in outcome of initiating estrogen therapy (ET around peri-menopause or several years after menopause in women are unknown. We hypothesize that the level of expression of a dominant negative estrogen receptor (ER β variant, ERβ2, may be a key factor determining the effectiveness of ET in post-menopausal women. We tested this hypothesis in ovariectomized nine month-old (an age when irregular estrous cycles occur female Sprague Dawley rats. Estradiol treatment was initiated either 6 days (Early ET, analogous to 4 months post-menopause in humans, or 180 days (Late ET, analogous to 11 years post-menopause in humans after ovariectomy. Although ERβ2 expression increased in all OVX rats, neurogenic and neuroprotective responses to estradiol differed in Early and Late ET. Early ET reduced ERβ2 expression in both hippocampus and white blood cells, increased the hippocampal cell proliferation as assessed by Ki-67 expression, and improved mobility in the forced swim test. Late ET resulted in either no or modest effects on these parameters. There was a close correlation between the degree of ERβ2 expression and the preservation of neural effects by ET after OVX in rats, supporting the hypothesis that persistent elevated levels of ERβ2 are a molecular basis for the diminished effectiveness of ET in late post-menopausal women. The correlation between the expression of ERβ2 in circulating white blood cells and brain cells suggests that ERβ2 expression in peripheral blood cells may be an easily accessible marker to predict the effective window for ET in the brain.

  3. Early uptake of HIV counseling and testing among pregnant women at different levels of health facilities - experiences from a community-based study in Northern Vietnam

    Directory of Open Access Journals (Sweden)

    Gammeltoft Tine

    2011-02-01

    Full Text Available Abstract Background HIV counselling and testing for pregnant women is a key factor for successful prevention of mother to child transmission of HIV. Women's access to testing can be improved by scaling up the distribution of this service at all levels of health facilities. However, this strategy will only be effective if pregnant women are tested early and provided enough counselling. Objective To assess early uptake of HIV testing and the provision of HIV counselling among pregnant women who attend antenatal care at primary and higher level health facilities. Methods A community based study was conducted among 1108 nursing mothers. Data was collected during interviews using a structured questionnaire focused on socio-economic background, reproductive history, experience with antenatal HIV counselling and testing as well as types of health facility providing the services. Results In all 91.0% of the women interviewed had attended antenatal care and 90.3% had been tested for HIV during their most recent pregnancy. Women who had their first antenatal checkup at primary health facilities were significantly more likely to be tested before 34 weeks of gestation (OR = 43.2, CI: 18.9-98.1. The reported HIV counselling provision was also higher at primary health facilities, where women in comparison with women attending higher level health facilities were nearly three or and four times more likely to receive pre-test (OR = 2.7; CI:2.1-3.5 and post-test counseling (OR = 4.0; CI: 2.3-6.8. Conclusions The results suggest that antenatal HIV counseling and testing can be scaled up to primary heath facilities and that such scaling up may enhance early uptake of testing and provision of counseling.

  4. Changes in vitamin-D metabolites and parathyroid hormone in plasma following cholecalciferol administration to pre- and postmenopausal women in the Netherlands in early spring and to postmenopausal women in Curacao

    NARCIS (Netherlands)

    vanderKlis, FRM; Jonxis, JHP; vanDoormaal, JJ; Sikkens, P; Saleh, AEC; Muskiet, FAJ

    1996-01-01

    To study the effect on plasma 25-hydroxycholecalciferol (25(OH)D), 1, 25-dihydroxycholecalciferol (1, 25(OH)(2)D) and parathyroid hormone (PTH) we supplemented premenopausal (aged 30 (so 7) years) and postmenopausal (aged 61 (so 2) years) white women living in The Netherlands in late winter/early sp

  5. Parametrial involvement in women with low-risk, early-stage cervical cancer.

    Science.gov (United States)

    Vanichtantikul, A; Tantbirojn, P; Manchana, T

    2017-09-01

    This study identified the incidence of parametrial involvement in low risk, early-stage cervical cancer patients and evaluated the factors associated with parametrial involvement. All stage IA2-IB1 cervical cancer patients who underwent radical hysterectomy with pelvic lymphadenectomy were retrospectively reviewed. Patients with squamous cell carcinoma or adenocarcinoma grade 1-2, tumour size less than 2 cm, no lymphovascular space invasion (LVSI), negative pelvic nodes and depth of stromal invasion (DSI) less than 10 mm were identified as the low-risk group. A total of 243 patients were eligible. Squamous cell carcinomas were the most frequent histological cell type (65%). Most patients (81.5%) had tumour size less than 2 cm. Thirteen patients (5.3%) had parametrial involvement, 77 (31.7%) had DSI more than 10 mm, 121 (49.8%) had more than 50% invasion, 119 (49%) had LVSI and 19 (7.5%) had node metastasis. Ninety-five patients (39.1%) were defined as low risk. None of low-risk group had parametrial involvement. DSI more than 10 mm or more than 50% stromal invasion, presence of LVSI and pelvic node metastasis were significant factors associated with parametrial involvement. Parametrial involvement in low-risk, early-stage cervical cancer is extremely low. Less radical surgery may be an alternative treatment option. © 2016 John Wiley & Sons Ltd.

  6. Comprehensive geriatric assessment for older women with early breast cancer – a systematic review of literature

    Directory of Open Access Journals (Sweden)

    Parks Ruth M

    2012-05-01

    Full Text Available Abstract Background The Comprehensive Geriatric Assessment (CGA is an analytical tool increasingly implemented in clinical practice. Breast cancer is primarily a disease of older people; however, most evidence-based research is aimed at younger patients. Methods A systematic review of literature was carried out to assess the use of CGA in older breast cancer patients for clinical decision making. The PubMed, Embase and Cochrane databases were searched. Results A total of nine useful full text article results were found. Only five of these were exclusively concerned with early breast cancer; thus, studies involving a variety of cancer types, stages and treatments were accepted, as long as they included early breast cancer.The results comprised a series of low sources of evidence. However, all results shared a common theme: the CGA has a use in determining patient suitability for different types of cancer treatment and subsequently maximizing the patient’s quality of life. Conclusions There is not yet sufficient high level evidence to instate CGA guidelines as a mandatory practice in the management of breast cancer, due to the heterogeneity of available studies. More studies need to be conducted to cement current work on the benefits of the CGA. An area of particular interest is with regard to treatment options, especially surgery and chemotherapy, and identifying patients who may be suitable for these treatments.

  7. BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family history.

    Directory of Open Access Journals (Sweden)

    Gaik Theng Toh

    Full Text Available BACKGROUND: In Asia, breast cancer is characterised by an early age of onset: In Malaysia, approximately 50% of cases occur in women under the age of 50 years. A proportion of these cases may be attributable, at least in part, to genetic components, but to date, the contribution of genetic components to breast cancer in many of Malaysia's ethnic groups has not been well-characterised. METHODOLOGY: Given that hereditary breast carcinoma is primarily due to germline mutations in one of two breast cancer susceptibility genes, BRCA1 and BRCA2, we have characterised the spectrum of BRCA mutations in a cohort of 37 individuals with early-onset disease (

  8. 'We make them feel special': The experiences of voluntary sector workers supporting asylum seeking and refugee women during pregnancy and early motherhood.

    Science.gov (United States)

    Balaam, Marie-Clare; Kingdon, Carol; Thomson, Gill; Finlayson, Kenneth; Downe, Soo

    2016-03-01

    BACKGROUND OR CONTEXT: refugee and asylum seekers are over represented in maternal death data. Many asylum seeking and refugee women access maternity care infrequently, or not at all. Little is known about the role of voluntary sector workers in supporting pregnant refugees and asylum seekers. to explore the experiences of voluntary sector workers supporting asylum seeking and refugee women during pregnancy and early motherhood. a qualitative descriptive study. individual and focus group interviews in three large urban centres in North West England, United Kingdom. two main themes emerged. 'Literally through hell and back' reflected the experiences of suffering, abuse and loss recounted to the volunteers by many of the women they work with. ׳Bridging the unacknowledged gap' related to the invisible processes undertaken by the workers as they enable the women they work with to over come their marginalised position. This included the difficulties of transience, and lack of enculturation, and to support them in accessing maternity care. voluntary sector workers supporting asylum seeking and refugee women strongly identified with the extreme suffering experienced by many of the women they work with. Through this contact, they become acutely aware of the gaps in provision for such women, and developed unique and innovative approaches to bridge this gap. These findings highlight the need for maternity health system to actively collaborate with, and learn from, voluntary agencies working in this field to improve the support offered to asylum seeking and refugee women. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. Type 2 diabetes mellitus and prognosis in early stage breast cancer women.

    Science.gov (United States)

    Kaplan, Muhammet Ali; Pekkolay, Zafer; Kucukoner, Mehmet; Inal, Ali; Urakci, Zuhat; Ertugrul, Hamza; Akdogan, Recai; Firat, Ugur; Yildiz, Ismail; Isikdogan, Abdurrahman

    2012-09-01

    It has been suggested that type 2 diabetes mellitus may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The aim of this study was to determine the impact of diabetes on disease-free survival (DFS) following mastectomy for breast cancer patients. The cases included in this retrospective study were selected from breast cancer women who had undergone mastectomy and completed adjuvant chemotherapy from 1998 to 2010. Patients were classified into two groups: diabetic and non-diabetic. Patients' age, sex, menopausal status, body mass index (BMI), histopathological features, tumor size, lymph node involvement, hormone receptor and HER2-neu status, and treatment types were recorded. There were 483 breast cancer patients included in the study. Postmenopausal patients' rate (53.7% vs. 36.8%, P = 0.016) and mean BMI levels were statistically higher (32.2 vs. 27.9, P = 0.007) in diabetic patients. There was no statistical difference for histological subgroup, grade, ER and PR positivity, HER2-neu overexpression rate, and tumor size between the diabetic and non-diabetic group. Lymph node involvements were statistically higher in diabetic patients compared with non-diabetic patients (P = 0.013). Median disease-free survival is 81 months (95% CI, 61.6-100.4) in non-diabetic patients and 36 months (95% CI, 13.6-58.4) in diabetic patients (P breast cancer.

  10. 围绝经期睡眠障碍的研究现状%Current Situation on Sleep Disorders in Menopausal Women

    Institute of Scientific and Technical Information of China (English)

    何爱先; 方芳

    2013-01-01

    睡眠障碍是女性围绝经期主要的临床症状之一,表现为入睡困难、睡中易醒、早醒等,严重影响患者的身心健康和生活质量。围绝经期睡眠障碍的发生可由激素水平改变,血管舒缩症状,情绪障碍及患者本身的疾病状态等因素引起。笔者结合近年来相关文献报道,对围绝经期睡眠障碍的诱导因素和治疗现状进行了综述。%Sleep disorders are main clinical symptoms in perimenopausal women. The symptoms are difficulty in initiating or maintaining sleep, early morning awakening and so on. These sleep problems had made serious im-pacts on the quality of women's life during menopausal periods. Menopausal sleep disorders can be caused by changes of serum estrogen levels, vasomotor symptoms, mood disorders and patient's state of disease. This paper presented an overview of inducing factors and current situation of menopausal disorder treatment.

  11. Rehabilitation effect of exercise prescription for the perimenopausal syndrome and the depression%运动处方对妇女围绝经期综合征及抑郁的干预效果

    Institute of Scientific and Technical Information of China (English)

    常文红; 陈长香; 马素慧; 赵雅宁; 马建芳

    2011-01-01

    目的 探寻围绝经期综合症妇女的临床干预新方法.方法 选取唐山市3所医院门诊就诊Kupperman评分≥11分,CES-D抑郁评分≥20分的围绝经期妇女,随机分为观察组和实验组各30人,对实验组给予“运动处方”训练,观察组进行常规指导,10周后进行评测.结果 实验组Kupperman评分由干预前的(24.80±8.002)分下降到干预后的(15.20±7.039)分,CES-D抑郁评分由(25.67 ±6.418)分下降到( 19.93 ±4.927)分,差异有统计学意义(F分别为23.344,15.063;P<0.01);观察组前后差异无统计学意义(P>0.05).实验组干预后Kupperman评分为(15.20±7.039)分,明显低于对照组的(23.13±7.447)分,CES-D抑郁评分为(19.93 ±4.927)明显低于对照组的(26.70±5.920)分,差异有统计学意义(F分别为18.560,23.158;P<0.01).结论 运动处方可有效降低女性围绝经期综合症及抑郁症状.%Objective To search for new clinical intervention method to perimenopausal syndrome women.Methods Choose Kupperman score ≥ 11 points,CES-D depression score ≥ 20 points hospital outpatients,who were perimenopausal syndrome moderate or above,definitely have depression,and were randomly divided into observation group and experimental group of each 30 people.T