WorldWideScience

Sample records for early growth performance

  1. Early growth performances of various seed sources of black (Prunus ...

    African Journals Online (AJOL)

    Early growth performances of various seed sources of black (Prunus serotina Erhr.) and wild cherry ( Prunus avium L.) seedlings on low and high elevation sites in the western Black Sea Region of Turkey.

  2. Growth curve analyses of the relationship between early maternal age and children's mathematics and reading performance.

    Science.gov (United States)

    Torres, D Diego

    2015-03-01

    Regarding the methods used to examine the early maternal age-child academic outcomes relationship, the extant literature has tended to examine change using statistical analyses that fail to appreciate that individuals vary in their rates of growth. Of the one study I have been able to find that employs a true growth model to estimate this relationship, the authors only controlled for characteristics of the maternal household after family formation; confounding background factors of mothers that might select them into early childbearing, a possible source of bias, were ignored. The authors' findings nonetheless suggested an inverse relationship between early maternal age, i.e., a first birth between the ages of 13 and 17, and Canadian adolescents' mean math performance at age 10. Early maternal age was not related to the linear slope of age. To elucidate whether the early maternal age-child academic outcomes association, treated in a growth context, is consistent with this finding, the present study built on it using US data and explored children's mathematics and reading trajectories from age 5 on. Its unique contribution is that it further explicitly controlled for maternal background factors and employed a three-level growth model with repeated measures of children nested within their mothers. Though the strength of the relationship varied between mean initial academic performance and mean academic growth, results confirmed that early maternal age was negatively related to children's mathematics and reading achievement, net of post-teen first birth child-specific and maternal household factors. Once maternal background factors were included, there was no statistically significant relationship between early maternal age and either children's mean initial mathematics and reading scores or their mean mathematics and reading growth. Copyright © 2014 Elsevier Inc. All rights reserved.

  3. Effects of early rumen development and solid feed composition on growth performance and abomasal health in veal calves.

    NARCIS (Netherlands)

    Berends, H.; Reenen, van C.G.; Stockhofe, N.; Gerrits, W.J.J.

    2012-01-01

    The experiment was designed to study the importance of early rumen development and of the composition of solid feed intake on growth performance and abomasal health in milk-fed veal calves. One hundred and six Holstein-Friesian male calves were included in the experiment, and studied during 2

  4. Early growth and postprandial appetite regulatory hormone responses

    DEFF Research Database (Denmark)

    Perälä, Mia-Maria; Kajantie, Eero; Valsta, Liisa M

    2013-01-01

    Strong epidemiological evidence suggests that slow prenatal or postnatal growth is associated with an increased risk of CVD and other metabolic diseases. However, little is known whether early growth affects postprandial metabolism and, especially, the appetite regulatory hormone system. Therefore......, we investigated the impact of early growth on postprandial appetite regulatory hormone responses to two high-protein and two high-fat content meals. Healthy, 65-75-year-old volunteers from the Helsinki Birth Cohort Study were recruited; twelve with a slow increase in BMI during the first year of life......, early growth may have a role in programming appetite regulatory hormone secretion in later life. Slow early growth is also associated with higher postprandial insulin and TAG responses but not with incretin levels....

  5. Early Growth Of Some Introduced Agroforestry Species In Akure ...

    African Journals Online (AJOL)

    This study investigated the early growth performance of potted seedlings of Grevillea robusta, Dalbergia sissoo, Albizia lebbeck, Prosopis juliflora and Acacia mearnsii . Two types of potting containers were used - the conventional black polypot (size: 10 cm x 15 cm) and the transparent \\"pure water\\' bags (size: 14 cm x 15 ...

  6. Performance of Jatropha curcas L. in Semi-arid Zone: Seed Germination, Seedling Growth and Early Field Growth

    Directory of Open Access Journals (Sweden)

    Sharif AHAMAD

    2013-05-01

    Full Text Available There is a lack of information on basic agronomic properties of Jatropha curcas L. (jatropha cultivation on the marginal lands in the semi-arids. Evaluation of agronomic performance of identified elite strains of J. curcas in marginal lands would be of paramount importance for addressing gap areas in their agronomic properties and subsequently for harnessing their optimum economic potentials. The present study undertook the task of analysing the growth performance of a high oil bearing elite strain of J. curcas–DARL-2 in degraded land in semi-arid zone of Deccan Plateau, India. While undertaking the assessment of growth performance of elite strain DARL-2, two other native (wild strains (namely AHN-1 and AHN-2 of J. curcas were also considered so that a comparative evaluation could be carried out. The role of gypsum was also investigated on J. curcas in the nursery stage as well its carry over effects on growth performance of transplanted trees in the field. Two types of substrates, gypsum-treated soil (GS and untreated soil (SL were used for growing seedlings of all the three jatropha strains. Seedlings (120-days-old of DARL-2 exhibited greater plant height, collar diameter and number of branches but root length was greater in the local strains. In the second year of field transplantation, DARL-2 strain exhibited significantly (p<0.05 greater plant height and number of branches/plant. No carry over effects of gypsum treatment were observed in field transplanted plants as none of the growth parameters significantly varied among the substrate types.

  7. The effects of swimming exercise and dissolved oxygen on growth performance, fin condition and precocious maturation of early-rearing Atlantic salmon Salmo salar

    Science.gov (United States)

    Waldrop, Thomas; Summerfelt, Steven T.; Mazik, Patricia M.; Good, Christopher

    2018-01-01

    Swimming exercise, typically measured in body-lengths per second (BL/s), and dissolved oxygen (DO), are important environmental variables in fish culture. While there is an obvious physiological association between these two parameters, their interaction has not been adequately studied in Atlantic salmon Salmo salar. Because exercise and DO are variables that can be easily manipulated in modern aquaculture systems, we sought to assess the impact of these parameters, alone and in combination, on the performance, health and welfare of juvenile Atlantic salmon. In our study, Atlantic salmon fry were stocked into 12 circular 0.5 m3 tanks in a flow-through system and exposed to either high (1.5–2 BL/s) or low (exercise and DO concentration on growth, feed conversion, survival and fin condition. By study's end, both increased swimming speed and higher DO were independently associated with a statistically significant increase in growth performance (p exercise and dissolved oxygen at saturation during Atlantic salmon early rearing can result in improved growth performance and a lower incidence of precocious parr.

  8. Rate of Language Growth in Children with Hearing Loss in an Auditory-Verbal Early Intervention Program

    Science.gov (United States)

    Jackson, Carla Wood; Schatschneider, Christopher

    2013-01-01

    This longitudinal study explored the rate of language growth of children in an early intervention program providing auditory-verbal therapy. A retrospective investigation, the study applied a linear growth model to estimate a mean growth curve and the extent of individual variation in language performance on the Preschool Language Scale, 4th ed.…

  9. Effect of chromium toxicity on germination and early seedling growth ...

    African Journals Online (AJOL)

    USER

    2010-07-19

    Jul 19, 2010 ... germination and early seedling growth of melon (Cucumis melo L.). Chromium ... chromium on seed germination and seedling growth- biomass in early ..... such critical regulatory mechanisms are likely to operate in seeds at ...

  10. Gender differences in early-career wage growth

    OpenAIRE

    Napari, Sami

    2007-01-01

    In Finnish manufacturing, the gender wage gap more than doubles during the first ten years in the labor market. This paper studies the factors contributing to the gender gap in early-career wage growth. The analysis shows that the size of the gender gap in wage growth varies with mobility status the gap being much higher when changing employers compared to within-firm wage growth. Several explanations for the gender gap in wage growth based on human capital theory and theory of compensating w...

  11. Early and extraordinary peaks in physical performance come with a longevity cost

    DEFF Research Database (Denmark)

    van de Vijver, Paul L; van Bodegom, David; Westendorp, Rudi G J

    2016-01-01

    Life history theory postulates a trade-off between development and maintenance. This trade-off is observed when comparing life histories of different animal species. In humans, however, it is debated if variation in longevity is explained by differences in developmental traits. Observational...... studies found a trade-off between early and high fecundity and longevity in women. Development encompasses more than fecundity and also concerns growth and physical performance. Here, we show a life history trade-off between early and above average physical performance and longevity in male Olympic...... suffered a 4.7-year longevity cost. (95% CI 2.1-7.5 years, p=0.001). This is the first time a life history trade-off between physical performance and longevity has been found in humans. This finding deepens our understanding of early developmental influences on the variation of longevity in humans....

  12. Early nutrition and its effect on growth, body composition, and later obesity

    DEFF Research Database (Denmark)

    Lind, Mads Vendelbo; Larnkjær, Anni; Mølgaard, Christian

    2017-01-01

    , intervention studies, and studies focusing on the potential mechanisms behind associations between early nutrition and different aspects of growth. There has been a special interest in factors with potential mediating effects between early nutrition and later growth such as growth factors and growth-related......Early nutrition is an important factor regulating both early and long-term growth and body composition, and therefore has important effects on the risk of later overweight and obesity. There is a lot of activity within this research area with a wealth of publications including observational studies...... hormones, appetite-related hormones, and factors with a potential programming effect, e.g., epigenetic programming. For this short review we have included 11 papers which we found of special interest published during the period from July 1, 2015 to June 30, 2016. We have chosen to focus mainly on 2 areas...

  13. Genetics of early growth vigour in lentil (Lens culinaris Medik.)

    Indian Academy of Sciences (India)

    Rapid early growth vigour, 70–75 days to flowering. Figure 1. Frequency distributions of early growth vigour based on seedling length in parents (DPL15, ILL7663 and ILL6002) and F2 populations derived from two crosses (DPL15 × ILL7663; DPL15 × ILL6002) in lentil. 324. Journal of Genetics, Vol. 92, No. 2, August 2013 ...

  14. Body Composition Growth Patterns in Early Infancy

    DEFF Research Database (Denmark)

    Andersen, Gregers Stig; Wibaek, Rasmus; Kaestel, Pernille

    2018-01-01

    OBJECTIVE: The objective of this study was to identify subgroups with distinct fat and fat-free growth patterns in the first 6 months of life and describe predictors of these different patterns. METHODS: A total of 510 apparently healthy Ethiopian infants were followed from birth to 6 months of a...... in regular anthropometric assessment and could be a mechanism linking early growth with later obesity and cardiometabolic risk....

  15. Characterizing the reproduction number of epidemics with early subexponential growth dynamics.

    Science.gov (United States)

    Chowell, Gerardo; Viboud, Cécile; Simonsen, Lone; Moghadas, Seyed M

    2016-10-01

    Early estimates of the transmission potential of emerging and re-emerging infections are increasingly used to inform public health authorities on the level of risk posed by outbreaks. Existing methods to estimate the reproduction number generally assume exponential growth in case incidence in the first few disease generations, before susceptible depletion sets in. In reality, outbreaks can display subexponential (i.e. polynomial) growth in the first few disease generations, owing to clustering in contact patterns, spatial effects, inhomogeneous mixing, reactive behaviour changes or other mechanisms. Here, we introduce the generalized growth model to characterize the early growth profile of outbreaks and estimate the effective reproduction number, with no need for explicit assumptions about the shape of epidemic growth. We demonstrate this phenomenological approach using analytical results and simulations from mechanistic models, and provide validation against a range of empirical disease datasets. Our results suggest that subexponential growth in the early phase of an epidemic is the rule rather the exception. Mechanistic simulations show that slight modifications to the classical susceptible-infectious-removed model result in subexponential growth, and in turn a rapid decline in the reproduction number within three to five disease generations. For empirical outbreaks, the generalized-growth model consistently outperforms the exponential model for a variety of directly and indirectly transmitted diseases datasets (pandemic influenza, measles, smallpox, bubonic plague, cholera, foot-and-mouth disease, HIV/AIDS and Ebola) with model estimates supporting subexponential growth dynamics. The rapid decline in effective reproduction number predicted by analytical results and observed in real and synthetic datasets within three to five disease generations contrasts with the expectation of invariant reproduction number in epidemics obeying exponential growth. The

  16. Characterizing the reproduction number of epidemics with early subexponential growth dynamics

    Science.gov (United States)

    Viboud, Cécile; Simonsen, Lone; Moghadas, Seyed M.

    2016-01-01

    Early estimates of the transmission potential of emerging and re-emerging infections are increasingly used to inform public health authorities on the level of risk posed by outbreaks. Existing methods to estimate the reproduction number generally assume exponential growth in case incidence in the first few disease generations, before susceptible depletion sets in. In reality, outbreaks can display subexponential (i.e. polynomial) growth in the first few disease generations, owing to clustering in contact patterns, spatial effects, inhomogeneous mixing, reactive behaviour changes or other mechanisms. Here, we introduce the generalized growth model to characterize the early growth profile of outbreaks and estimate the effective reproduction number, with no need for explicit assumptions about the shape of epidemic growth. We demonstrate this phenomenological approach using analytical results and simulations from mechanistic models, and provide validation against a range of empirical disease datasets. Our results suggest that subexponential growth in the early phase of an epidemic is the rule rather the exception. Mechanistic simulations show that slight modifications to the classical susceptible–infectious–removed model result in subexponential growth, and in turn a rapid decline in the reproduction number within three to five disease generations. For empirical outbreaks, the generalized-growth model consistently outperforms the exponential model for a variety of directly and indirectly transmitted diseases datasets (pandemic influenza, measles, smallpox, bubonic plague, cholera, foot-and-mouth disease, HIV/AIDS and Ebola) with model estimates supporting subexponential growth dynamics. The rapid decline in effective reproduction number predicted by analytical results and observed in real and synthetic datasets within three to five disease generations contrasts with the expectation of invariant reproduction number in epidemics obeying exponential growth. The

  17. The amazing growth of the early church

    Directory of Open Access Journals (Sweden)

    Wim A. Dreyer

    2012-11-01

    Full Text Available The church grew rapidly during the first centuries. The question is: Why? Generations of scholars approached this question from different perspectives and with different methods. Historical research, analysis of early Christian texts and theological reflection were the most common methods used to shed light on the growth of the church. In this contribution five different models of growth were discussed, using the approach of A.M. Schor as a point of departure. These models of church growth were put under the headings of an apostolic mission model, values reproduction model, social reaction model, network model with an institutional model added.

  18. The effect of manganese on early growth of fluted pumpkin ( telfairia ...

    African Journals Online (AJOL)

    The effect of manganese on early growth of fluted pumpkin (telfairia occidentalis hook f) in an ultisol. ER Orhue, CNC Nwaoguala. Abstract. The trials were conducted at the experimental site of University of Benin Teaching and Research Farm to determine the influence of Mn on early growth, nutrient content and uptake by ...

  19. Estimating the Broad-Sense Heritability of Early Growth of Cowpea

    OpenAIRE

    Xu, Nicole W.; Xu, Shizhong; Ehlers, Jeff

    2009-01-01

    Cowpea is an important tropical crop. It provides a large proportion of the food resource for the African human population and their livestock. The yield and quality of cowpea have been dramatically improved through traditional breeding strategies for the past few decades. However, reports of heritability estimates for early growth of cowpea are rare. We designed a simple experiment to estimate the broad-sense heritability of early growth. We randomly selected 15 cowpea varieties among a tota...

  20. Stimulation effect of early growth in crops by low dose radiation

    International Nuclear Information System (INIS)

    Kim, J.S.; Song, H.S.; Kim, J.K.; Lee, Y.K.; Lee, Y.B.

    1998-01-01

    Germination rate and early growth in crop such as rice,soybean,and perilla were observed after irradiation of γ-ray (Co-60) in order to determine the effects of low does radiation. The low dose radiation was able to improve the early growth in crops and their agricultural characters. Germination rate of 2Gy-irradiatied rice seeds was high and also were seeding height and fresh weight of the 0.5 Gy-irradiated. Germination rate and early growth of soybean were high in 4Gy-irradiated group. Perilla gew of so promisingly after after low dose irradiation, however there slightly increasing effects on germination rate, seeding height and fresh weight at 2Gt-, 1Gy-, and 1Gy irradiated group, respectively. (author)

  1. The effects of early time laser drive on hydrodynamic instability growth in National Ignition Facility implosions

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, J. L.; Clark, D. S.; Suter, L. J. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Masse, L. P. [CEA, DAM, DIF, 91297 Arpajon (France)

    2014-09-15

    Defects on inertial confinement fusion capsule surfaces can seed hydrodynamic instability growth and adversely affect capsule performance. The dynamics of shocks launched during the early period of x-ray driven National Ignition Facility (NIF) implosions determine whether perturbations will grow inward or outward at peak implosion velocity and final compression. In particular, the strength of the first shock, launched at the beginning of the laser pulse, plays an important role in determining Richtmyer-Meshkov (RM) oscillations on the ablation front. These surface oscillations can couple to the capsule interior through subsequent shocks before experiencing Rayleigh-Taylor (RT) growth. We compare radiation hydrodynamic simulations of NIF implosions to analytic theories of the ablative RM and RT instabilities to illustrate how early time laser strength can alter peak velocity growth. We develop a model that couples the RM and RT implosion phases and captures key features of full simulations. We also show how three key parameters can control the modal demarcation between outward and inward growth.

  2. Growth monitoring as an early detection tool: a systematic review

    NARCIS (Netherlands)

    Scherdel, P.; Dunkel, L.; Dommelen, P. van; Goulet, O.; Salaün, J.F.; Brauner, R.; Heude, B.; Chalumeau, M.

    2016-01-01

    Growth monitoring of apparently healthy children aims at early detection of serious underlying disorders. However, existing growth-monitoring practices are mainly based on suboptimal methods, which can result in delayed diagnosis of severe diseases and inappropriate referrals. We did a systematic

  3. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

    Science.gov (United States)

    Moyon, Thomas; Antignac, Jean-Philippe; Qannari, El Mostafa; Croyal, Mikaël; Soumah, Mohamed; David-Sochard, Agnès; Billard, Hélène; Legrand, Arnaud; Boscher, Cécile; Darmaun, Dominique; Rozé, Jean-Christophe

    2018-01-01

    Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother’s milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother’s breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced “slower” (n = 15, −1.54 ± 0.42 Z-score) or “faster” (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the “faster-growth” group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography–mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies. PMID:29385065

  4. The effects of swimming exercise and dissolved oxygen on growth performance, fin condition and precocious maturation of early-rearing Atlantic salmon Salmo salar

    Science.gov (United States)

    Waldrop, Thomas; Summerfelt, Steven T.; Mazik, Patricia M.; Good, Christopher

    2018-01-01

    Swimming exercise, typically measured in body-lengths per second (BL/s), and dissolved oxygen (DO), are important environmental variables in fish culture. While there is an obvious physiological association between these two parameters, their interaction has not been adequately studied in Atlantic salmon Salmo salar. Because exercise and DO are variables that can be easily manipulated in modern aquaculture systems, we sought to assess the impact of these parameters, alone and in combination, on the performance, health and welfare of juvenile Atlantic salmon. In our study, Atlantic salmon fry were stocked into 12 circular 0.5 m3 tanks in a flow-through system and exposed to either high (1.5–2 BL/s) or low (salmon early rearing can result in improved growth performance and a lower incidence of precocious parr.

  5. Effect of insulin-like growth factor-I during the early postnatal period in intrauterine growth-restricted rats.

    Science.gov (United States)

    Ikeda, Naho; Shoji, Hiromichi; Suganuma, Hiroki; Ohkawa, Natsuki; Kantake, Masato; Murano, Yayoi; Sakuraya, Koji; Shimizu, Toshiaki

    2016-05-01

    Insulin-like growth factor-I (IGF-I) is essential for perinatal growth and development; low serum IGF-I has been observed during intrauterine growth restriction (IUGR). We investigated the effects of recombinant human (rh) IGF-I in IUGR rats during the early postnatal period. Intrauterine growth restriction was induced by bilateral uterine artery ligation in pregnant rats. IUGR pups were divided into two groups injected daily with rhIGF-I (2 mg/kg; IUGR/IGF-I, n = 16) or saline (IUGR/physiologic saline solution (PSS), n = 16) from postnatal day (PND) 7 to 13. Maternal sham-operated pups injected with saline were used as controls (control, n = 16). Serum IGF-I and IGF binding proteins (IGFBP) 3 and 5 were measured on PND25. The expression of Igf-i, IGF-I receptor (Igf-ir), Igfbp3, and 5 mRNA in the liver and brain was measured using real-time polymerase chain reaction on PND25. Immunohistochemical staining of the liver for IGF expression was performed. Mean bodyweight on PND3 and PND25 in the IUGR pups (IUGR/IGF-I and IUGR/PSS) was significantly lower than that of the control pups. Serum IGF-I and hepatic Igf-ir mRNA in the IUGR pups were significantly lower than those in the control pups. In the IUGR/IGF-I group, hepatic Igfbp3 mRNA and liver immunohistochemical staining were increased. In the IUGR/PSS and control pups, there were no significant differences between these two groups in serum IGFBP3 and IGFBP5, hepatic Igf-i and Igfbp-5 mRNA, or brain Igf mRNA. No benefits on body and brain weight gain but an effective increase in hepatic IGFBP-3 was observed after treatment with 2 mg/kg rhIGF-I during the early postnatal period. © 2015 Japan Pediatric Society.

  6. Early growth patterns are associated with intelligence quotient scores in children born small-for-gestational age.

    Science.gov (United States)

    Varella, Marcia H; Moss, William J

    2015-08-01

    To assess whether patterns of growth trajectory during infancy are associated with intelligence quotient (IQ) scores at 4 years of age in children born small-for-gestational age (SGA). Children in the Collaborative Perinatal Project born SGA were eligible for analysis. The primary outcome was the Stanford-Binet IQ score at 4 years of age. Growth patterns were defined based on changes in weight-for-age z-scores from birth to 4 months and 4 to 12 months of age and consisted of steady, early catch-up, late catch-up, constant catch-up, early catch-down, late catch-down, constant catch-down, early catch-up & late catch-down, and early catch-down & late catch-up. Multivariate linear regression was used to assess associations between patterns of growth and IQ. We evaluated patterns of growth and IQ in 5640 children. Compared with children with steady growth, IQ scores were 2.9 [standard deviation (SD)=0.54], 1.5 (SD=0.63), and 2.2 (SD=0.9) higher in children with early catch-up, early catch-up and later catch-down, and constant catch-up growth patterns, respectively, and 4.4 (SD=1.4) and 3.9 (SD=1.5) lower in children with early catch-down & late catch-up, and early catch-down growth patterns, respectively. Patterns in weight gain before 4 months of age were associated with differences in IQ scores at 4 years of age, with children with early catch-up having slightly higher IQ scores than children with steady growth and children with early catch-down having slightly lower IQ scores. These findings have implications for early infant nutrition in children born SGA. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Early Smoking, Education, and Labor Market Performance

    NARCIS (Netherlands)

    Palali, Ali

    2015-01-01

    This study investigates the effects of early smoking on educational attainment and labor market performance. The results show that early smoking adversely affects educational attainment and initial labor market performance, but only for males. The effect of early smoking on initial labor market

  8. A case of functional growth hormone deficiency and early growth retardation in a child with IFT172 mutations.

    Science.gov (United States)

    Lucas-Herald, Angela K; Kinning, Esther; Iida, Aritoshi; Wang, Zheng; Miyake, Noriko; Ikegawa, Shiro; McNeilly, Jane; Ahmed, S Faisal

    2015-04-01

    Ciliopathies are a group of rare conditions that present through a wide range of manifestations. Given the relative common occurrence of defects of the GH/IGF-I axis in children with short stature and growth retardation, the association between ciliopathies and these defects needs further attention. Our patient is a boy who was born at term and noted to have early growth retardation and weight gain within the first 18 months of life. Biochemical tests demonstrated low IGF-I but a normal peak GH on stimulation and an adequate increase in IGF-I on administration of recombinant human growth hormone (rhGH). A magnetic resonance imaging scan revealed pituitary hypoplasia and an ectopic posterior pituitary. His growth responded well to rhGH therapy. Subsequently he also developed a retinopathy of his rods and cones, metaphyseal dysplasia, and hypertension with renal failure requiring renal replacement therapy. Whole-exome sequencing demonstrated compound heterozygous mutations of IFT172, thus consistent with a ciliopathy. This is the first reported case of a child with a mutation in IFT172 who presented with growth retardation in early childhood and was initially managed as a case of functional GH deficiency that responded to rhGH therapy. This case highlights the importance of ciliary function in pituitary development and the link between early onset growth failure and ciliopathies.

  9. EFFECT OF DROUGHT STRESS ON EARLY GROWTH OF ...

    African Journals Online (AJOL)

    Ridwan

    ABSTRACT. Drought and high temperatures are said to have triggered increased tree mortality and could be linked to the menace of climate change. This research therefore investigated the effect of drought stress on early growth of Adansonia digitata where seedlings were exposed to different watering frequencies (Once ...

  10. Effects of early rumen development and solid feed composition on growth performance and abomasal health in veal calves.

    Science.gov (United States)

    Berends, H; van Reenen, C G; Stockhofe-Zurwieden, N; Gerrits, W J J

    2012-06-01

    The experiment was designed to study the importance of early rumen development and of the composition of solid feed intake on growth performance and abomasal health in milk-fed veal calves. One hundred and six Holstein-Friesian male calves were included in the experiment, and studied during 2 successive 12-wk periods (period 1 and period 2). In a 2 × 2 factorial arrangement, effects of partially replacing milk replacer by solid feed during period 1 and partially replacing dry matter (DM) intake from maize silage and barley straw by concentrate during period 2 were tested. Solid feed during period 1 consisted of maize silage, barley straw, and concentrate (25:25:50 on a DM basis). Solid feed during period 2 consisted of maize silage and barley straw (50:50 ratio on DM basis) for the nonconcentrate groups, and maize silage, barley straw and concentrates (25:25:50 on a DM basis) for the concentrate groups. At the end of period 1 (n=16) and at the end of period 2 (n=90), parameters of animal performance, rumen development, rumen fermentation, ruminal drinking, and abomasal damage were examined. Partially replacing milk replacer by solid feed during period 1 resulted in early rumen development (ERD) at the end of period 1, characterized by increased rumen weight, and an increased epithelial and absorptive surface area. Both ERD and partially replacing roughage by concentrates in period 2 increased the rumen development score at the end of period 2. Although ERD calves consumed more solid feed and less milk replacer during period 1 and 2 than non-ERD calves, carcass weight gains at 25 wk were identical, and utilization of the solid feed provided appeared similar to that of milk replacer. Partially replacing roughage by concentrates in period 2 increased dressing percentage and warm carcass weight. Plaque formation at the rumen mucosa was unaffected by ERD or partially replacing roughage by concentrates and generally low in all calves. The prevalence of large scars in

  11. Excess dietary cholesterol may have an adverse effect on growth performance of early post-larval Litopenaeus vannamei

    Science.gov (United States)

    2012-01-01

    One experiment was conducted to determine the nutritive value of cholesterol for post-larval shrimp, Litopenaeus vannamei. Four isoenergetic and isonitrogenous diets supplemented with four levels of cholesterol (D1, D2, D3 and D4 with 0, 0.5%, 1% and 2% cholesterol, respectively) were fed to triplicate groups of L. vannamei shrimp (mean initial wet weight 0.8 mg) for 27 days. After the trial, shrimp fed the D1 diet had the best growth performance (final body weights: FBW; weight gain: WG; specific growth rate: SGR), while there was no significant difference between diet treatments with respect to survival. The whole body crude protein level in the shrimp decreased with the increase in dietary cholesterol levels, while the whole body crude lipid level in shrimps in the D4 diet treatment was significantly higher (P vannamei; excess dietary cholesterol may thus lead to adverse effects on the growth performance of post-larval shrimp. PMID:22958647

  12. Excess dietary cholesterol may have an adverse effect on growth performance of early post-larval Litopenaeus vannamei

    Directory of Open Access Journals (Sweden)

    Niu Jin

    2012-06-01

    Full Text Available Abstract One experiment was conducted to determine the nutritive value of cholesterol for post-larval shrimp, Litopenaeus vannamei. Four isoenergetic and isonitrogenous diets supplemented with four levels of cholesterol (D1, D2, D3 and D4 with 0, 0.5%, 1% and 2% cholesterol, respectively were fed to triplicate groups of L. vannamei shrimp (mean initial wet weight 0.8 mg for 27 days. After the trial, shrimp fed the D1 diet had the best growth performance (final body weights: FBW; weight gain: WG; specific growth rate: SGR, while there was no significant difference between diet treatments with respect to survival. The whole body crude protein level in the shrimp decreased with the increase in dietary cholesterol levels, while the whole body crude lipid level in shrimps in the D4 diet treatment was significantly higher (P L. vannamei; excess dietary cholesterol may thus lead to adverse effects on the growth performance of post-larval shrimp.

  13. Early metabolic defects in dexamethasone-exposed and undernourished intrauterine growth restricted rats.

    Directory of Open Access Journals (Sweden)

    Emmanuel Somm

    Full Text Available Poor fetal growth, also known as intrauterine growth restriction (IUGR, is a worldwide health concern. IUGR is commonly associated with both an increased risk in perinatal mortality and a higher prevalence of developing chronic metabolic diseases later in life. Obesity, type 2 diabetes or metabolic syndrome could result from noxious "metabolic programming." In order to better understand early alterations involved in metabolic programming, we modeled IUGR rat pups through either prenatal exposure to synthetic glucocorticoid (dams infused with dexamethasone 100 µg/kg/day, DEX or prenatal undernutrition (dams feeding restricted to 30% of ad libitum intake, UN. Physiological (glucose and insulin tolerance, morphometric (automated tissue image analysis and transcriptomic (quantitative PCR approaches were combined during early life of these IUGR pups with a special focus on their endocrine pancreas and adipose tissue development. In the absence of catch-up growth before weaning, DEX and UN IUGR pups both presented basal hyperglycaemia, decreased glucose tolerance, and pancreatic islet atrophy. Other early metabolic defects were model-specific: DEX pups presented decreased insulin sensitivity whereas UN pups exhibited lowered glucose-induced insulin secretion and more marked alterations in gene expression of pancreatic islet and adipose tissue development regulators. In conclusion, these results show that before any catch-up growth, IUGR rats present early physiologic, morphologic and transcriptomic defects, which can be considered as initial mechanistic basis of metabolic programming.

  14. VEGETATIVE GROWTH AND EARLY PRODUCTION OF SIX OLIVE CULTIVARS, IN SOUTHERN ATACAMA DESERT, CHILE

    Directory of Open Access Journals (Sweden)

    Freddy MORA

    2007-12-01

    Full Text Available Tree survival, early fruit production, vegetative growth and alternate bearing were examined in six different olive cultivars (Barnea, Biancolilla, Coratina, Empeltre, Koroneiki and Leccino under intensive agronomic conditions i southern Atacama Desert, in the Coquimbo Region of Chile. The cultivars were evaluated over four successive years and had a high survival rate (93% confi rming their potential for these dry-lands. Fruit production (recorded over the growing seasons 2002-2003, vegetative growth (2000-2003 and alternate bearing differed signifi cantly among cultivars. Olive selection in intensively managed planting at the southern part of the Atacama Desert depends on matching specifi c cultivars to sites on which they perform the best.

  15. Intrauterine growth restriction and placental gene expression in severe preeclampsia, comparing early-onset and late-onset forms.

    Science.gov (United States)

    Nevalainen, Jaana; Skarp, Sini; Savolainen, Eeva-Riitta; Ryynänen, Markku; Järvenpää, Jouko

    2017-10-26

    To evaluate placental gene expression in severe early- or late-onset preeclampsia with intrauterine growth restriction compared to controls. Chorionic villus sampling was conducted after cesarean section from the placentas of five women with early- or late-onset severe preeclampsia and five controls for each preeclampsia group. Microarray analysis was performed to identify gene expression differences between the groups. Pathway analysis showed over-representation of gene ontology (GO) biological process terms related to inflammatory and immune response pathways, platelet development, vascular development, female pregnancy and reproduction in early-onset preeclampsia. Pathways related to immunity, complement and coagulation cascade were overrepresented in the hypergeometric test for the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Ten genes (ABI3BP, C7, HLA-G, IL2RB, KRBOX1, LRRC15, METTL7B, MPP5, RFLNB and SLC20A) had a ≥±1 fold expression difference in severe early-onset preeclampsia group compared to early controls. There were 362 genes that had a ≥±1 fold expression difference in severe early-onset preeclampsia group compared to late-onset preeclampsia group including ABI3BP, C7, HLA-G and IL2RB. There are significant differences in placental gene expression between severe early- and late-onset preeclampsia when both are associated with intrauterine growth restriction. ABI3BP, C7, HLA-G and IL2RB might contribute to the development of early form of severe preeclampsia.

  16. Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish.

    Science.gov (United States)

    Leerberg, Dena M; Sano, Kaori; Draper, Bruce W

    2017-09-01

    The vertebrate ovary and testis develop from a sexually indifferent gonad. During early development of the organism, primordial germ cells (the gamete lineage) and somatic gonad cells coalesce and begin to undergo growth and morphogenesis to form this bipotential gonad. Although this aspect of development is requisite for a fertile adult, little is known about the genetic regulation of early gonadogenesis in any vertebrate. Here, we provide evidence that fibroblast growth factor (Fgf) signaling is required for the early growth phase of a vertebrate bipotential gonad. Based on mutational analysis in zebrafish, we show that the Fgf ligand 24 (Fgf24) is required for proliferation, differentiation, and morphogenesis of the early somatic gonad, and as a result, most fgf24 mutants are sterile as adults. Additionally, we describe the ultrastructural elements of the early zebrafish gonad and show that distinct somatic cell populations can be identified soon after the gonad forms. Specifically, we show that fgf24 is expressed in an epithelial population of early somatic gonad cells that surrounds an inner population of mesenchymal somatic gonad cells that are in direct contact with the germ cells, and that fgf24 is required for stratification of the somatic tissue. Furthermore, based on gene expression analysis, we find that differentiation of the inner mesenchymal somatic gonad cells into functional cell types in the larval and early juvenile-stage gonad is dependent on Fgf24 signaling. Finally, we argue that the role of Fgf24 in zebrafish is functionally analogous to the role of tetrapod FGF9 in early gonad development.

  17. The effects of dietary protein levels on the population growth, performance, and physiology of honey bee workers during early spring.

    Science.gov (United States)

    Zheng, Benle; Wu, Zaifu; Xu, Baohua

    2014-01-01

    This study was conducted to investigate the effects of dietary protein levels on honey bee colonies, specifically the population growth, physiology, and longevity of honey bee workers during early spring. Diets containing four different levels of crude protein (25.0, 29.5, 34.0, or 38.5%) and pure pollen (control) were evaluated. Twenty-five colonies of honey bees with sister queens were used in the study. We compared the effects of the different bee diets by measuring population growth, emergent worker weight, midgut proteolytic enzyme activity, hypopharyngeal gland development, and survival. After 48 d, the cumulative number of workers produced by the colonies ranged from 22,420 to 29,519, providing a significant fit to a quadratic equation that predicts the maximum population growth when the diet contains 31.7% crude protein. Significantly greater emergent worker weight, midgut proteolytic enzyme activity, hypopharyngeal gland acini, and survival were observed in the colonies that were fed diets containing 34.0% crude protein compared with the other crude protein levels. Although higher emergent worker weight and survival were observed in the colonies that were fed the control diet, there were no significant differences between the control colonies and the colonies that were fed 34.0% crude protein. Based on these results, we concluded that a dietary crude protein content of 29.5-34.0% is recommended to maximize the reproduction rate of honey bee colonies in early spring. © The Author 2014. Published by Oxford University Press on behalf of the Entomological Society of America.

  18. Genetic and environmental trends of early growth traits in the ...

    African Journals Online (AJOL)

    Data from the Elsenburg Dormer sheep stud were used to estimate genetic and environmental change in early growth traits from 1943 to 1990. .... The Elsenburg stud is not only the foundation Dormer stud, ... derivative-free algorithm. Genet.

  19. Food, growth and time: Elsie Widdowson's and Robert McCance's research into prenatal and early postnatal growth.

    Science.gov (United States)

    Buklijas, Tatjana

    2014-09-01

    Cambridge scientists Robert McCance and Elsie Widdowson are best known for their work on the British food tables and wartime food rations, but it is their research on prenatal and early postnatal growth that is today seen as a foundation of the fields studying the impact of environment upon prenatal development and, consequently, adult disease. In this essay I situate McCance's and Widdowson's 1940s human and 1950s experimental studies in the context of pre-war concerns with fetal growth and development, especially within biochemistry, physiology and agriculture; and the Second World War and post-war focus on the effects of undernutrition during pregnancy upon the fetus. I relate Widdowson's and McCance's research on the long-term effects of early undernutrition to the concern with recovery from early trauma so pertinent in post-war Europe and with sensitive (critical) periods, a concept of high importance across different fields. Finally I discuss how, following a hiatus in which fetal physiology engaged with different questions and stressed fetal autonomy, interest in the impact of environment upon prenatal growth and development revived towards the end of the twentieth century. The new field of "developmental origins of health and disease", I suggest, has provided a context in which Widdowson's and McCance's work has regained importance. Copyright © 2013 Elsevier Ltd. All rights reserved.

  20. Early Acceleration of Mathematics Students and its Effect on Growth in Self-esteem: A Longitudinal Study

    Science.gov (United States)

    Ma, Xin

    2002-11-01

    The Longitudinal Study of American Youth (LSAY) database was employed to examine the educational practice of early acceleration of students of mathematics on the development of their self-esteem across the entire secondary grade levels. Students were classified into three different academic categories (gifted, honors, and regular). Results indicated that, in terms of the development of their self-esteem, gifted students benefited from early acceleration, honors students neither benefited nor were harmed by early acceleration, and regular students were harmed by early acceleration. Early acceleration in mathematics promoted significant growth in self-esteem among gifted male students and among gifted, honors, and regular minority students. When students were accelerated, schools showed similar average growth in self-esteem among gifted students and regular students and a large effect of general support for mathematics on the average growth in self-esteem among honors students.

  1. Early parenteral nutrition and growth outcomes in preterm infants: a systematic review and meta-analysis.

    Science.gov (United States)

    Moyses, Helen E; Johnson, Mark J; Leaf, Alison A; Cornelius, Victoria R

    2013-04-01

    The achievement of adequate nutritional intakes in preterm infants is challenging and may explain the poor growth often seen in this group. The use of early parenteral nutrition (PN) is one potential strategy to address this problem, although the benefits and harms are unknown. We determined whether earlier administration of PN benefits growth outcomes in preterm infants. We conducted a systematic review of randomized controlled trials (RCTs) and observational studies. Eight RCTs and 13 observational studies met the inclusion criteria (n = 553 and 1796 infants). The meta-analysis was limited by disparate growth-outcome measures. An assessment of bias was difficult because of inadequate reporting. Results are given as mean differences (95% CIs). Early PN reduced the time to regain birth weight by 2.2 d (1.1, 3.2 d) for RCTs and 3.2 d (2.0, 4.4 d) in observational studies. The maximum percentage weight loss with early PN was lower by 3.1 percentage points (1.7, 4.5 percentage points) for RCTs and by 3.5 percentage points (2.6, 4.3 percentage points) for observational studies. Early PN improved weight at discharge or 36 wk postmenstrual age by 14.9 g (5.3, 24.5 g) (observational studies only), but no benefit was shown for length or head circumference. There was no evidence that early PN significantly affects risk of mortality, necrotizing enterocolitis, sepsis, chronic lung disease, intraventricular hemorrhage, or cholestasis. The results of this review, although subject to some limitations, show that early PN provides a benefit for some short-term growth outcomes. No evidence that early PN increases morbidity or mortality was found. Neonatal research would benefit from the development of a set of core growth outcome measures.

  2. Assessing the effect of phosphorus application on early growth of maize at Sunderbazar, Lamjung, Nepal

    Directory of Open Access Journals (Sweden)

    Ram Kumar Shrestha

    2016-12-01

    Full Text Available Phosphorus (P is an essential nutrient element for maize production. A pot experiment was conducted during May-June, 2015 to assess the effects of different rates of P on early growth of maize plant at Sundarbazar, Lamjung. Two maize varieties (Rato Makai and Poshilo Makai-1 were subjected to four P levels (0 kg ha-1, 13 kg ha-1, 18 kg ha-1, and 23 kg ha-1 in randomized complete block design with four replications. The effects of different P level on root elongation, root biomass, plant height, root shoot biomass ratio and total dry matter were investigated at 45 days after sowing. For all parameters, the maximum value was obtained when soil was added with 18 kg P ha-1 & the minimum value under the control of 0 kg P ha-1. Maize varieties differed significantly in terms of all the parameters under study, and Poshilo Makai-1 performed better than Rato Makai at all P levels. So, from this result, it can be concluded that Poshilo Makai-1 appeared to be P efficient over Rato Makai at early growth stage. However, it would be necessary to look at the response of crop up to maturity and at wider range of P to have the better insight of their relative performance.

  3. Establishment and Early Growth of Willow at Different Levels of Weed Competition and Nitrogen Fertilization

    DEFF Research Database (Denmark)

    Edelfeldt, Stina; Lundkvist, Anneli; Forkman, Johannes

    2016-01-01

    To evaluate the effects of weed competition and nitrogen fertilization on the early growth performance of willow, cuttings of the clone Tora (Salix schwerinii x S. viminalis) were planted in buckets together with model weeds (spring barley or white mustard) sown 15, 26, and 30 days after willow...... gave higher willow biomass production in willow with weeds sown after 26 or 30 days. Type of model weed had no effect on willow performance. Weed biomass and maximum shoot height were higher in weeds planted without willows compared to the willow-weed mixtures. A high nitrogen level gave more weed...... biomass when planted without willows and in the willow-weed mixture with weeds sown after 15 days. We conclude that for the given high density of willow, competition from weeds emerging soon after willow planting had strong effect on early production. Furthermore, if there is a risk of weed infestation...

  4. Beyond birth-weight: early growth and adolescent blood pressure in a Peruvian population

    Directory of Open Access Journals (Sweden)

    Robie Sterling

    2014-06-01

    Full Text Available Background. Longitudinal investigations into the origins of adult essential hypertension have found elevated blood pressure in children to accurately track into adulthood, however the direct causes of essential hypertension in adolescence and adulthood remains unclear.Methods. We revisited 152 Peruvian adolescents from a birth cohort tracked from 0 to 30 months of age, and evaluated growth via monthly anthropometric measurements between 1995 and 1998, and obtained anthropometric and blood pressure measurements 11–14 years later. We used multivariable regression models to study the effects of infantile and childhood growth trends on blood pressure and central obesity in early adolescence.Results. In regression models adjusted for interim changes in weight and height, each 0.1 SD increase in weight for length from 0 to 5 months of age, and 1 SD increase from 6 to 30 months of age, was associated with decreased adolescent systolic blood pressure by 1.3 mm Hg (95% CI −2.4 to −0.1 and 2.5 mm Hg (95% CI −4.9 to 0.0, and decreased waist circumference by 0.6 (95% CI −1.1 to 0.0 and 1.2 cm (95% CI −2.3 to −0.1, respectively. Growth in infancy and early childhood was not significantly associated with adolescent waist-to-hip ratio.Conclusions. Rapid compensatory growth in early life has been posited to increase the risk of long-term cardiovascular morbidities such that nutritional interventions may do more harm than good. However, we found increased weight growth during infancy and early childhood to be associated with decreased systolic blood pressure and central adiposity in adolescence.

  5. First trimester screening for intra-uterine growth restriction and early-onset pre-eclampsia

    NARCIS (Netherlands)

    Vandenberghe, G.; Mensink, I.; Twisk, J.W.; Blankenstein, M.A.; Heijboer, A.C.; van Vugt, J.M.

    2011-01-01

    Objective: To assess first trimester placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) as screening markers for early-onset pre-eclampsia (PE) and intra-uterine growth restriction (IUGR). Methods: PlGF concentration was retrospectively measured in first trimester

  6. Longitudinal study of computerized cardiotocography in early fetal growth restriction

    NARCIS (Netherlands)

    Wolf, H.; Arabin, B.; Lees, Christoph C.; Oepkes, D.; Prefumo, Federico; Thilaganathan, B.; Todros, T.; Visser, G.H.A.; Bilardo, Caterina M.; Derks, J. B.; Diemert, A.; Duvekot, Johannes J.; Ferrazzi, E.; Frusca, T.; Hecher, K.; Marlow, N.; Martinelli, P.; Ostermayer, E.; Papageorghiou, Aris T.; Scheepers, Hubertina C. J.; Schlembach, D.; Schneider, K. T M; Valcamonico, A.; van Wassenaer-Leemhuis, A.; Ganzevoort, W.; Aktas, Ayse; Borgione, Silvia; Brezinka, Christoph; Calvert, Sandra; Chaoui, Rabih; Cornette, Jerome M J; Diehl, Thilo; van Eyck, Jim; Fratelli, Nicola; van Haastert, Inge Lot; Johnson, Samantha; Lobmaier, Silvia; Lopriore, Enrico; Mansi, Giuseppina; Missfelder-Lobos, Hannah; Martelli, Paola; Maso, Gianpaolo; Maurer-Fellbaum, Ute; Van Charante, Nico Mensing; De Tollenaer, Susanne Mulder; Moore, Tamanna; Napolitano, Raffaele; Oberto, Manuela; Ogge, Giovanna; van der Post, Joris Am; Preston, Lucy; Raimondi, Francesco; Reiss, Irwin K M; Rigano, Serena; Schuit, Ewoud; Skabar, Aldo; Spaanderman, Marc E.; Weisglas-Kuperus, Nynke; Zimmermann, Andrea

    2017-01-01

    Objectives: To explore whether, in early fetal growth restriction (FGR), the longitudinal pattern of fetal heart rate (FHR) short-term variation (STV) can be used to identify imminent fetal distress and whether abnormalities of FHR recordings are associated with 2-year infant outcome. Methods: The

  7. Effects of different levels of protein supplements in the diet of early-weaned yaks on growth performance, intestinal development, and immune response to tuberculosis

    Directory of Open Access Journals (Sweden)

    Haibo Zhang

    2015-06-01

    Full Text Available This study was conducted to determine the effects of different levels of crude protein (CP supplements to the diet of early-weaned yaks on their growth performance, intestinal development, and immune response. Forty 3-month-old weaned yaks were selected and assigned to four dietary groups (Control, 17, 19 and 21% CP. Dietary CP supplements had a significant effect on average daily gain (ADG, crypt depth (CD (duodenum, jejunum and ileum, villous height (VH (duodenum, jejunum and ileum and CD/VH (jejunum and ileum. Average daily gain, CD (duodenum, jejunum and ileum and VH (ileum showed quadratic increases as the dietary CP increased, whereas CD/VH (jejunum and ileum ratios showed quadratic decreases. Blood urea nitrogen (BUN, glucose (GLU, immunoglobulin G (IgG, IgM, interleukin-1 (IL-1, IL-2, tumor necrosis factor (TNF-α, and interferon (IFN-γ concentrations increased significantly, whereas albumin (ALB, alanine aminotransferase (ALT and aspartate aminotransferase (AST decreased significantly with dietary CP supplements. Dietary CP supplements significantly increased the concentrations of IL-6, TNF-α, IFN-γ and the nuclear factor of activated T cell transcription factor (NFAT for gene expression. As the dietary CP supplements increased, IL-6, IFN-γ and NF-AT gene expression showed quadratic increases. These results showed that the appropriate dietary CP supplementation improved the growth performance and intestinal development of earlyweaned yaks and thus that the CP supplements were beneficial and enhanced the humoral immunity response of yaks.

  8. First trimester screening for intra-uterine growth restriction and early-onset pre-eclampsia

    NARCIS (Netherlands)

    Vandenberghe, G.; Mensink, I.; Twisk, J. W. R.; Blankenstein, M. A.; Heijboer, A. C.; van Vugt, J. M. G.

    2011-01-01

    To assess first trimester placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) as screening markers for early-onset pre-eclampsia (PE) and intra-uterine growth restriction (IUGR). PlGF concentration was retrospectively measured in first trimester serum specimens of 23

  9. Extent of Spine Deformity Predicts Lung Growth and Function in Rabbit Model of Early Onset Scoliosis.

    Directory of Open Access Journals (Sweden)

    J Casey Olson

    Full Text Available Early onset deformity of the spine and chest wall (initiated <8 years of age is associated with increased morbidity at adulthood relative to adolescent onset deformity of comparable severity. Presumably, inhibition of thoracic growth during late stage alveolarization leads to an irreversible loss of pulmonary growth and thoracic function; however the natural history of this disease from onset to adulthood has not been well characterized. In this study we establish a rabbit model of early onset scoliosis to establish the extent that thoracic deformity affects structural and functional respiratory development. Using a surgical right unilateral rib-tethering procedure, rib fusion with early onset scoliosis was induced in 10 young New Zealand white rabbits (3 weeks old. Progression of spine deformity, functional residual capacity, total lung capacity, and lung mass was tracked through longitudinal breath-hold computed tomography imaging up to skeletal maturity (28 weeks old. Additionally at maturity forced vital capacity and regional specific volume were calculated as functional measurements and histo-morphometry performed with the radial alveolar count as a measure of acinar complexity. Data from tethered rib rabbits were compared to age matched healthy control rabbits (N = 8. Results show unilateral rib-tethering created a progressive spinal deformity ranging from 30° to 120° curvature, the severity of which was strongly associated with pulmonary growth and functional outcomes. At maturity rabbits with deformity greater than the median (55° had decreased body weight (89%, right (59% and left (86% lung mass, right (74% and left (69% radial alveolar count, right lung volume at total lung capacity (60%, and forced vital capacity (75%. Early treatment of spinal deformity in children may prevent pulmonary complications in adulthood and these results provide a basis for the prediction of pulmonary development from thoracic structure. This model may

  10. Early Growth of Improved Acacia mangium at Different Planting Densities

    Directory of Open Access Journals (Sweden)

    Arif Nirsatmanto

    2016-08-01

    Full Text Available Integrating tree improvement into silvicultural practices is essential in forest plantation. Concerning this fact, Acacia mangium spacing trial planted using genetically improved seed was established in West Java. This study was aimed to evaluate the impact of ages and planting density on early growth of improved seed A. mangium in the spacing trial. Improved seed from 2 seed orchards (SSO-5 and SSO-20 and a control of unimproved seed from seed stand (SS-7 were tested together in spacing 3 × 3 m and 2 × 2 m. Height, diameter, stem volume, and stand volume were observed at 3 ages. The results showed that improved seed consistently outperformed to unimproved seed. Ages were highly significant for all traits, but the significant difference varied among traits and seed sources for planting density and the interactions. High density performed better growth than low density at first year, and they were varied in subsequent ages depending on traits and seed sources. Improved seed from less intensity selection orchard was less tolerance to high density than that from high intensity selection orchard, but the tolerance was reversed in low density. Improved seed A. mangium from different level of genetic selection has responded differently in behavior to the changes of planting density.

  11. New Predictive Model at 11+0 to 13+6 Gestational Weeks for Early-Onset Preeclampsia With Fetal Growth Restriction.

    Science.gov (United States)

    Chang, Ying; Chen, Xu; Cui, Hong-Yan; Li, Xing; Xu, Ya-Ling

    2017-05-01

    The aim of the present study was to determine a predictive model for early-onset preeclampsia with fetal growth restriction (FGR) to be used at 11 +0 to 13 +6 gestational weeks, by combining the maternal serum level of pregnancy-associated plasma protein-A (PAPP-A), placental growth factor (PLGF), placental protein 13 (PP13), soluble endoglin (sEng), mean arterial pressure (MAP), and uterine artery Doppler. This was a retrospective cohort study of 4453 pregnant women. Uterine artery Doppler examination was conducted in the first trimester. Maternal serum PAPP-A, PLGF, PP13, and sEng were measured. Mean arterial pressure was obtained. Women were classified as with/without early-onset preeclampsia, and women with preeclampsia were classified as with/without FGR. Receiver operating characteristic analysis was performed to determine the value of the model. There were 30 and 32 pregnant women with early-onset preeclampsia with and without FGR. The diagnosis rate of early-onset preeclampsia with FGR was 67.4% using the predictive model when the false positive rate was set at 5% and 73.2% when the false positive rate was 10%. The predictive model (MAP, uterine artery Doppler measurements, and serum biomarkers) had some predictive value for the early diagnosis (11 +0 to 13 +6 gestational weeks) of early-onset preeclampsia with FGR.

  12. Biplot Analysis of Silicon Dioxide on Early Growth of Sunflower

    Directory of Open Access Journals (Sweden)

    Sabaghnia Naser

    2016-06-01

    Full Text Available Research into nanotechnology has advanced in almost all fields of technology and the aim of this study was to evaluate the role of nano-silicon dioxide (nano-SiO2 in germination performance sunflower. Germination and seedling growth are the most important stage of plant development and are critical factors to crop production and are essential to achieve optimum performance. The effects of pre-germination hydration in solutions of nano-SiO2 (0, 0.2, 0.4, 0.6, 0.8, 1 and 1.2 mM for 8 h on germination characteristics of sunflower were investigated. The trait by treatment (TT biplot explained 93% of the total variation of the standardized data (77% and 16% for the first and second principal components, respectively. According to polygon-view of TT biplot, T2 (0.2 mM had the highest values for all of the measured traits except mean germination time and the time to 50% germination. The germination percentage was determined as the best trait and showed the high association with promptness index, energy of germination and germination rate traits. The results of the present study indicated that pre-sowing seed treatments with low concentration of nano-SiO2 had favorable effect sunflower seed germination and seedling early growth. Such a similar outcome could be applied in the future to outline other crops in response to nano-particles as well as to help define tolerance tools for recommendations in stressful conditions in the world.

  13. Comparison of Swirl Sign and Black Hole Sign in Predicting Early Hematoma Growth in Patients with Spontaneous Intracerebral Hemorrhage.

    Science.gov (United States)

    Xiong, Xin; Li, Qi; Yang, Wen-Song; Wei, Xiao; Hu, Xi; Wang, Xing-Chen; Zhu, Dan; Li, Rui; Cao, Du; Xie, Peng

    2018-01-29

    BACKGROUND Early hematoma growth is associated with poor outcome in patients with spontaneous intracerebral hemorrhage (ICH). The swirl sign (SS) and the black hole sign (BHS) are imaging markers in ICH patients. The aim of this study was to compare the predictive value of these 2 signs for early hematoma growth. MATERIAL AND METHODS ICH patients were screened for the appearance of the 2 signs within 6 h after onset of symptoms. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the 2 signs in predicting early hematoma growth were assessed. The accuracy of the 2 signs in predicting early hematoma growth was analyzed by receiver-operator analysis. RESULTS A total of 200 patients were enrolled in this study. BHS was found in 30 (15%) patients, and SS was found in 70 (35%) patients. Of the 71 patients with early hematoma growth, BHS was found on initial computed tomography scans in 24 (33.8%) and SS in 33 (46.5%). The sensitivity, specificity, PPV, and NPV of BHS for predicting early hematoma growth were 33.8%, 95.3%, 80.0%, and 72.0%, respectively. The sensitivity, specificity, PPV, and NPV of SS were 46.5%, 71.3%, 47.0%, and 71.0%, respectively. The area under the curve was 0.646 for BHS and 0.589 for SS (P=0.08). Multivariate logistic regression showed that presence of BHS is an independent predictor of early hematoma growth. CONCLUSIONS The Black hole sign seems to be good predictor for hematoma growth. The presence of swirl sign on admission CT does not independently predict hematoma growth in patients with ICH.

  14. Early kit mortality and growth in farmed mink are affected by litter size rather than nest climate

    DEFF Research Database (Denmark)

    Schou, Toke Munk; Malmkvist, Jens

    2017-01-01

    increased growth (P=0.026). Nest box temperature had little effect on early kit survival and growth, which could be due to dams’ additional maternal behaviour. Therefore, we cannot confirm that temperature is the primary reason for kit mortality, under the conditions of plenty straw access for maternal nest......We investigated the effects of nest box climate on early mink kit mortality and growth. We hypothesised that litters in warm nest boxes experience less hypothermia-induced mortality and higher growth rates during the 1st week of life. This study included data from 749, 1-year-old breeding dams...... building. Instead, prenatal and/or parturient litter size is the primary factor influencing early kit vitality. The results indicate that the focus should be on litter size and dam welfare around the times of gestation and birth to increase early kit survival in farmed mink....

  15. Germination and early seedling growth of Pinus densata Mast. provenances

    Science.gov (United States)

    Yulan Xu; Nianhui Cai; Bin He; Ruili Zhang; Wei Zhao; Jianfeng Mao; Anan Duan; Yue Li; Keith Woeste

    2016-01-01

    We studied seed germination and early seedling growth of Pinus densata to explore the range of variability within the species and to inform afforestation practices. Phenotypes were evaluated at a forest tree nursery under conditions that support Pinus yunnanensis, one of the presumed parental species of P. densata...

  16. Root-zone temperature and water availability affect early root growth of planted longleaf pine

    Science.gov (United States)

    M.A. Sword

    1995-01-01

    Longleaf pine seedlings from three seed sources were exposed to three root-zone temperatures and three levels of water availability for 28 days. Root growth declined as temperature and water availability decreased. Root growth differed by seed source. Results suggest that subtle changes in the regeneration environment may influence early root growth of longleaf pine...

  17. Perinatal programming of childhood asthma: early fetal size, growth trajectory during infancy, and childhood asthma outcomes.

    Science.gov (United States)

    Turner, Steve

    2012-01-01

    The "fetal origins hypothesis" or concept of "developmental programming" suggests that faltering fetal growth and subsequent catch-up growth are implicated in the aetiology of cardiovascular disease. Associations between reduced birth weight, rapid postnatal weight gain, and asthma suggest that there are fetal origins to respiratory disease. The present paper first summarises the literature relating birth weight and post natal growth trajectories to asthma outcomes. Second, issues regarding the interpretation of antenatal fetal ultrasound measurements are discussed. Finally, recent reports linking antenatal measurement and growth trajectory to early childhood asthma outcomes are discussed. Understanding the nature and timing of factors which influence antenatal growth may give important insight into the antecedents of early-onset asthma with implications for interventions.

  18. STATISTICAL GROWTH MODELING OF LONGITUDINAL DT-MRI FOR REGIONAL CHARACTERIZATION OF EARLY BRAIN DEVELOPMENT.

    Science.gov (United States)

    Sadeghi, Neda; Prastawa, Marcel; Fletcher, P Thomas; Gilmore, John H; Lin, Weili; Gerig, Guido

    2012-01-01

    A population growth model that represents the growth trajectories of individual subjects is critical to study and understand neurodevelopment. This paper presents a framework for jointly estimating and modeling individual and population growth trajectories, and determining significant regional differences in growth pattern characteristics applied to longitudinal neuroimaging data. We use non-linear mixed effect modeling where temporal change is modeled by the Gompertz function. The Gompertz function uses intuitive parameters related to delay, rate of change, and expected asymptotic value; all descriptive measures which can answer clinical questions related to growth. Our proposed framework combines nonlinear modeling of individual trajectories, population analysis, and testing for regional differences. We apply this framework to the study of early maturation in white matter regions as measured with diffusion tensor imaging (DTI). Regional differences between anatomical regions of interest that are known to mature differently are analyzed and quantified. Experiments with image data from a large ongoing clinical study show that our framework provides descriptive, quantitative information on growth trajectories that can be directly interpreted by clinicians. To our knowledge, this is the first longitudinal analysis of growth functions to explain the trajectory of early brain maturation as it is represented in DTI.

  19. Early childhood growth patterns and school-age respiratory resistance, fractional exhaled nitric oxide and asthma.

    Science.gov (United States)

    Casas, Maribel; den Dekker, Herman T; Kruithof, Claudia J; Reiss, Irwin K; Vrijheid, Martine; de Jongste, Johan C; Jaddoe, Vincent W V; Duijts, Liesbeth

    2016-12-01

    Greater infant weight gain is associated with lower lung function and increased risk of childhood asthma. The role of early childhood peak growth patterns is unclear. We assessed the associations of individually derived early childhood peak growth patterns with respiratory resistance, fractional exhaled nitric oxide, wheezing patterns, and asthma until school-age. We performed a population-based prospective cohort study among 5364 children. Repeated growth measurements between 0 and 3 years of age were used to derive standard deviation scores (s.d.s) of peak height and weight velocities (PHV and PWV, respectively), and body mass index (BMI) and age at adiposity peak. Respiratory resistance and fractional exhaled nitric oxide were measured at 6 years of age. Wheezing patterns and asthma were prospectively assessed by annual questionnaires. We also assessed whether any association was explained by childhood weight status. Greater PHV was associated with lower respiratory resistance [Z-score (95% CI): -0.03 (-0.04, -0.01) per s.d.s increase] (n = 3382). Greater PWV and BMI at adiposity peak were associated with increased risks of early wheezing [relative risk ratio (95% CI): 1.11 (1.06, 1.16), 1.26 (1.11, 1.43), respectively] and persistent wheezing [relative risk ratio (95% CI): 1.09 (1.03, 1.16), 1.37 (1.17, 1.60), respectively] (n = 3189 and n = 3005, respectively). Childhood weight status partly explained these associations. No other associations were observed. PWV and BMI at adiposity peak are critical for lung developmental and risk of school-age wheezing. Follow-up studies at older ages are needed to elucidate whether these effects persist at later ages. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Growth performance, immune status and organ morphometry in ...

    African Journals Online (AJOL)

    Growth performance, immune status and organ morphometry in broilers fed Bacillus subtilis -supplemented diet. ... In conclusion, B. subtilis-type probiotics contributed positively to better growth performance, improved immune system and modulated morphology of lymphoid organs and gut mucosa in broilers. Keywords: ...

  1. Perinatal Programming of Childhood Asthma: Early Fetal Size, Growth Trajectory during Infancy, and Childhood Asthma Outcomes

    Directory of Open Access Journals (Sweden)

    Steve Turner

    2012-01-01

    Full Text Available The “fetal origins hypothesis” or concept of “developmental programming” suggests that faltering fetal growth and subsequent catch-up growth are implicated in the aetiology of cardiovascular disease. Associations between reduced birth weight, rapid postnatal weight gain, and asthma suggest that there are fetal origins to respiratory disease. The present paper first summarises the literature relating birth weight and post natal growth trajectories to asthma outcomes. Second, issues regarding the interpretation of antenatal fetal ultrasound measurements are discussed. Finally, recent reports linking antenatal measurement and growth trajectory to early childhood asthma outcomes are discussed. Understanding the nature and timing of factors which influence antenatal growth may give important insight into the antecedents of early-onset asthma with implications for interventions.

  2. The relationship between early growth and survival of hatchling saltwater crocodiles (Crocodylus porosus in captivity.

    Directory of Open Access Journals (Sweden)

    Matthew L Brien

    Full Text Available Hatchling fitness in crocodilians is affected by "runtism" or failure to thrive syndrome (FTT in captivity. In this study, 300 hatchling C. porosus, artificially incubated at 32°C for most of their embryonic development, were raised in semi-controlled conditions, with growth criteria derived for the early detection of FTT (within 24 days. Body mass, four days after hatching (BM4d, was correlated with egg size and was highly clutch specific, while snout-vent length (SVL4d was much more variable within and between clutches. For the majority of hatchlings growth trajectories within the first 24 days continued to 90 days and could be used to predict FTT affliction up to 300 days, highlighting the importance of early growth. Growth and survival of hatchling C. porosus in captivity was not influenced by initial size (BM4d, with a slight tendency for smaller hatchlings to grow faster in the immediate post-hatching period. Strong clutch effects (12 clutches on affliction with FTT were apparent, but could not be explained by measured clutch variables or other factors. Among individuals not afflicted by FTT (N = 245, mean growth was highly clutch specific, and the variation could be explained by an interaction between clutch and season. FTT affliction was 2.5 times higher among clutches (N = 7 that hatched later in the year when mean minimum air temperatures were lower, compared with those clutches (N = 5 that hatched early in the year. The results of this study highlight the importance of early growth in hatchling C. porosus, which has implications for the captive management of this species.

  3. Ammonia Volatilization from Urea-Application Influenced Germination and Early Seedling Growth of Dry Direct-Seeded Rice

    Directory of Open Access Journals (Sweden)

    Xiaoli Qi

    2012-01-01

    Full Text Available Poor seed germination and early seedling growth associated with urea-induced soil ammonia volatilization are major constraints in the adoption of dry direct-seeded rice. To directly examine soil ammonia volatilization and its damage to seed germination and early seedling growth of dry direct-seeded rice when urea is applied at seeding, two Petri-dish incubation experiments and a field experiment were conducted. Ammonia volatilization due to urea application significantly reduced seed germination and early seedling growth of dry direct-seedling rice. NBPT significantly reduced ammonia volatilization following urea application. The application of ammonium sulfate, instead of urea at seeding, may mitigate poor crop establishment of dry direct-seeded rice. Root growth of dry direct-seeded rice was more seriously inhibited by soil ammonia volatilization than that of shoot. Results suggest that roots are more sensitive to soil ammonia toxicity than shoots in dry direct-seeded rice system when N is applied as urea at seeding.

  4. Flooding tolerance in cotton (gossypium hirsutum l.) at early vegetative and reproductive growth stages

    International Nuclear Information System (INIS)

    Hussain, A.

    2014-01-01

    Periodic flooding at any growth stage greatly affects growth and yield of crops. In order to develop flooding tolerant cotton cultivar and to identify the most sensitive growth stage to periodic flooding, a field experiment was conducted in which 60-cultivars/accessions/lines were subjected to two week flooding at seedling/early vegetative, flower and boll formation growth stages. Pre- and post-flooding soil analysis was also carried out. Nitrate-N was greatly reduced due to flooding applied at all growth stages, whereas NH4-N increased significantly. Similarly, Fe and Mn were also increased to many folds in flooded soils. Under hypoxic conditions, depletion of nitrates and toxic effects of accumulated NH4, Fe and Mn caused severe damages to cotton plants and even death of plants. Of the three growth stages, early vegetative growth stage is most sensitive to two week flooding. Flooding imposed at the flowering and boll formation growth stages caused a substantial amount of yield penalty. On the basis of survival percentage, the 60-cultivars/accessions/lines were categorized into tolerant (61%), moderately tolerant (31=60%) and sensitive (31%) to short term flooding. At the seedling or early vegetative growth stage, genotypes DPL-SR-2 followed by 124-F and MNH-427 were most tolerant to flooding, while AET-5, N-KRISHMA, LRA-5166, CEDIX and H-142 were ranked as sensitive to flooding stress. At the flowering stage, the genotype NIAB-92 followed by S-14 and MNH-427 were highly tolerant to flooding. At the boll formation stage, genotypes DPL-70010-N followed by GH-11-9-75 and B-2918-2 were highly tolerant waterlogging. More than 50% of the genotypes maintained the degree of flooding tolerance at three growth stages. However, on the basis of survival percentage at three growth stages, genotypes MNH-564, FH-114, MNH-786 and CIM-573 were included in the tolerant group and the genotypes N-KRISHMA, LRA-5166, CEDIX and H-142 were included in the sensitive group. These

  5. Characterizing the reproduction number of epidemics with early subexponential growth dynamics

    DEFF Research Database (Denmark)

    Chowell, Gerardo; Viboud, Cécile; Simonsen, Lone

    2016-01-01

    in the first few disease generations, before susceptible depletion sets in. In reality, outbreaks can display subexponential (i.e. polynomial) growth in the first few disease generations, owing to clustering in contact patterns, spatial effects, inhomogeneous mixing, reactive behaviour changes or other...... and simulations from mechanistic models, and provide validation against a range of empirical disease datasets. Our results suggest that subexponential growth in the early phase of an epidemic is the rule rather the exception. Mechanistic simulations show that slight modifications to the classical susceptible...

  6. Developmental plasticity of growth and digestive efficiency in dependence of early-life food availability

    Science.gov (United States)

    Kotrschal, Alexander; Szidat, Sönke; Taborsky, Barbara

    2014-01-01

    Nutrition is a potent mediator of developmental plasticity. If food is scarce, developing organisms may invest into growth to outgrow size-dependent mortality (short-term benefit) and/or into an efficient digestion system (long-term benefit). We investigated this potential trade-off, by determining the influence of food availability on juvenile body and organ growth, and on adult digestive efficiency in the cichlid fish Simochromis pleurospilus. We reared two groups of fish at constant high or low food rations, and we switched four other groups between these two rations at an early and late juvenile period. We measured juvenile growth and organ sizes at different developmental stages and determined adult digestive efficiency. Fish kept at constant, high rations grew considerably faster than low-food fish. Nevertheless, S. pleurospilus partly buffered the negative effects of low food availability by developing heavier digestive organs, and they were therefore more efficient in digesting their food as adults. Results of fish exposed to a ration switch during either the early or late juvenile period suggest (i) that the ability to show compensatory growth after early exposure to low food availability persists during the juvenile period, (ii) that digestive efficiency is influenced by varying juvenile food availability during the late juvenile phase and (iii) that the efficiency of the adult digestive system is correlated with the growth rate during a narrow time window of juvenile period. PMID:25866430

  7. Contrasting Strategies of Alfalfa Stem Elongation in Response to Fall Dormancy in Early Growth Stage: The Tradeoff between Internode Length and Internode Number

    Science.gov (United States)

    Wang, Zongli; Sun, Qizhong

    2015-01-01

    Fall dormancy (FD) in alfalfa (Medicago sativa L.) can be described using 11 FD ratings, is widely used as an important indicator of stress resistance, productive performance and spring growth. However, the contrasting growth strategies in internode length and internode number in alfalfa cultivars with different FD rating are poorly understood. Here, a growth chamber study was conducted to investigate the effect of FD on plant height, aboveground biomass, internode length, and internode number in alfalfa individuals in the early growth stages. In order to simulate the alfalfa growth environment in the early stage, 11 alfalfa cultivars with FD ratings from one to 11 were chosen and seeded at the greenhouse, and then were transplanted into an artificial growth chamber. The experimental design was a randomized complete block in a split-plot arrangement with three replicates. Plant height, above-ground biomass, internode length, and internode number were measured in early growth stage in all individuals. Our findings showed that plant height and the aboveground biomass of alfalfa did not significantly differ among 11 different FD rated cultivars. Also, internode length and internode number positively affected plant height and the aboveground biomass of alfalfa individuals and the average internode length significantly increased with increasing FD rating. However, internode number tended to sharply decline when the FD rating increased. Moreover, there were no correlations, slightly negative correlations, and strongly negative correlations between internode length and internode number in alfalfa individuals among the three scales, including within-FD ratings, within-FD categories and inter-FD ratings, respectively. Therefore, our results highlighted that contrasting growth strategies in stem elongation were adopted by alfalfa with different FD ratings in the early growth stage. Alfalfa cultivars with a high FD rating have longer internodes, whereas more dormant alfalfa

  8. Alternative Student Growth Measures for Teacher Evaluation: Implementation Experiences of Early-Adopting Districts. REL 2015-093

    Science.gov (United States)

    McCullough, Moira; English, Brittany; Angus, Megan Hague; Gill, Brian

    2015-01-01

    Alternative student growth measures for teacher evaluation: Implementation experiences of early-adopting districts: State requirements to include student achievement growth in teacher evaluations are prompting the development of alternative ways to measure growth in grades and subjects not covered by state assessments. These alternative growth…

  9. Oxygen-sensitive regulation and neuroprotective effects of growth hormone-dependent growth factors during early postnatal development.

    Science.gov (United States)

    Jung, Susan; Boie, Gudrun; Doerr, Helmuth-Guenther; Trollmann, Regina

    2017-04-01

    Perinatal hypoxia severely disrupts metabolic and somatotrophic development, as well as cerebral maturational programs. Hypoxia-inducible transcription factors (HIFs) represent the most important endogenous adaptive mechanisms to hypoxia, activating a broad spectrum of growth factors that contribute to cell survival and energy homeostasis. To analyze effects of systemic hypoxia and growth hormone (GH) therapy (rhGH) on HIF-dependent growth factors during early postnatal development, we compared protein (using ELISA) and mRNA (using quantitative RT PCR) levels of growth factors in plasma and brain between normoxic and hypoxic mice (8% O 2 , 6 h; postnatal day 7 , P7) at P14. Exposure to hypoxia led to reduced body weight ( P controls and was associated with significantly reduced plasma levels of mouse GH ( P controls. In addition, rhGH treatment increased cerebral IGF-1, IGF-2, IGFBP-2, and erythropoietin mRNA levels, resulting in significantly reduced apoptotic cell death in the hypoxic, developing mouse brain. These data indicate that rhGH may functionally restore hypoxia-induced systemic dysregulation of the GH/IGF-1 axis and induce upregulation of neuroprotective, HIF-dependent growth factors in the hypoxic developing brain. Copyright © 2017 the American Physiological Society.

  10. Employee well-being, early-retirement intentions, and company performance.

    Science.gov (United States)

    von Bonsdorff, Monika E; Vanhala, Sinikka; Seitsamo, Jorma; Janhonen, Minna; Husman, Päivi

    2010-12-01

    To explore the relationship between employee well-being and early-retirement intentions, and the extent to which early-retirement intentions are associated with company performance. This study is based on cross-sectional survey data on the ageing employees of the Finnish metal industry and retail trade, collected in 2007 (company-level n = 129, employee-level n = 1281). It was analyzed using multinomial logistic and multiple regression analysis. Poor work ability, frequent emotional exhaustion, low organizational commitment, and job control were associated with the prevalence of early-retirement intentions among aging employees in both industries. Metal industry employees' early-retirement intentions were associated with weaker company performance measured by the perceptions of the manager. By enhancing well-being, employees may stay at work for longer rather than retiring early. Early-retirement intentions can be counterproductive for companies.

  11. Effects of Salinity on Seed Germination and Early Growth of Moringa oleifera

    International Nuclear Information System (INIS)

    Kidombo, S.D; KOech, E.K

    2007-01-01

    Moringa oleifera Iam is a very important species because of it's multiple uses. The tree grows in many parts of the world including Asia, Africa, Central America and South America. In Kenya, it grows in drier regions of Baringo, Kibwezi, Mandera and the coastal strip. These regions are known to have substantially high level of soluble salts. The study aims at finding the effect of salinity on germination and early seedling growth of M. oleifera seedlings. This was tested in Moi University department of forestry laboratory by varying the concentration of Nacl moles (0.01, 0.03, 0.05, 0.07 and 0.09) in germination medium. The petri dishes with germination media were placed in the incubator at 30 degrees Celsius each containing 25 seeds of each treatment replicated four times. The effect of seedling growth and development was tested in the greenhouse. This was done by varying the concentration of Nacl moles (0.05, 0.15, 0.25, 0.35 and 0.45) in the forest soil used in the experiment. After germination one seedling per treatment was randomly selected and then carefully dug. The root length, shoot height, total dry matter, stem dry matter and leaves dry matter were measured. This was repeated at intervals of one week for seven weeks. The data obtained from the experiments were analysed using ANOVA based on generalized linear modelling procedures. The tests indicated that M. oleifera seed germination and early seedling growth was significantly (p<0.05) affected by salinity. The seedlings also demonstrated development of swellings in the root region and the development of multiple stems for salt concentrations of 0.05 moles and above. These observations show that M. oleifera is affected by salinity in both seed germination and early seedling growth

  12. Early Childhood Memory and Attention as Predictors of Academic Growth Trajectories

    Science.gov (United States)

    Stipek, Deborah; Valentino, Rachel A.

    2015-01-01

    Longitudinal data from the children of the National Longitudinal Survey of Youth (NLSY) were used to assess how well measures of short-term and working memory and attention in early childhood predicted longitudinal growth trajectories in mathematics and reading comprehension. Analyses also examined whether changes in memory and attention were more…

  13. Early growth and chronic disease: a public health overview.

    Science.gov (United States)

    Law, Catherine

    2005-07-01

    Infant and childhood growth result from and reflect a range of influences in pre- and postnatal life. These include nutrition, burden of infection and the psycho-social environment. Nutrition in young children is dependent on individual level factors such as fetal experience, infant feeding and weaning practices, and on societal factors such as education of women and economic conditions. The relationship of early postnatal growth to adult disease may be indicative or causal, and may reveal both biological and sociological processes. Although non-insulin-dependent diabetes mellitus (NIDDM) and obesity are risk factors for ischaemic heart disease, the relationships of these three conditions to infant growth differ. Poor infant growth has been associated with higher levels of NIDDM and ischaemic heart disease, but lower levels of adult obesity. Most research has been of populations living in developed countries at different stages of nutritional transition. However, differences in context are not simply limited to the stage of the nutritional transition. They also need to consider the nature of that transition and its social correlates, which may result in the clustering of aetiological influences such as increased body mass and poverty. The size of effect of the relationship of infant growth to adult disease is important not only to determine its relative aetiological importance but also for its potential for public health policy. Such policy also needs to consider the relationships of infant growth to a range of outcomes, both health and human capital, which are not the subject of this workshop.

  14. A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks

    Directory of Open Access Journals (Sweden)

    Cécile Viboud

    2016-06-01

    Conclusions: Our findings reveal significant variation in epidemic growth patterns across different infectious disease outbreaks and highlights that sub-exponential growth is a common phenomenon, especially for pathogens that are not airborne. Sub-exponential growth profiles may result from heterogeneity in contact structures or risk groups, reactive behavior changes, or the early onset of interventions strategies, and consideration of “deceleration parameters” may be useful to refine existing mathematical transmission models and improve disease forecasts.

  15. Early Life Growth Predictors of Childhood Adiposity Trajectories and Future Risk for Obesity: Birth to Twenty Cohort.

    Science.gov (United States)

    Munthali, Richard J; Kagura, Juliana; Lombard, Zané; Norris, Shane A

    2017-10-01

    There is growing evidence of variations in adiposity trajectories among individuals, but the influence of early life growth patterns on these trajectories is underresearched in low- and middle-income countries. Therefore, our aim was to examine the association between early life conditional weight gain and childhood adiposity trajectories. We previously identified distinct adiposity trajectories (four for girls and three for boys) in black South African children (boys = 877; girls = 947). The association between the trajectories and early life growth patterns, and future obesity risk was assessed by multivariate linear and multinomial logistic and logistic regressions. Conditional weight gain independent of height was computed for infancy (0-2 years) and early childhood (2-4 years). Conditional weight gain before 5 years of age was significantly associated with early onset of obesity or overweight (excess weight) BMI trajectories in both boys and girls. In girls, greater conditional weight gain in infancy was associated with increased relative risk of being in the early-onset obese to morbid obese trajectory, with relative risk ratios of 2.03 (95% confidence interval: 1.17-3.52) compared to belonging to a BMI trajectory in the normal range. Boys and girls in the early-onset obesity or overweight BMI trajectories were more likely to be overweight or obese in early adulthood. Excessive weight gain in infancy and early childhood, independent of linear growth, predicts childhood and adolescent BMI trajectories toward obesity. These results underscore the importance of early life factors in the development of obesity and other NCDs in later life.

  16. Effects of NaCl stress on seed germination, early seedling growth ...

    African Journals Online (AJOL)

    Effects of salt stress on seed germination, early seedling growth and some physiological characteristics were evaluated for four cauliflower species in seven treatments of salinity including 0 (control), 34, 68, 102, 136, 170 and 204 mM NaCl in a three replicated randomized completely block design (RCBD). This result shows ...

  17. Assessing the Effects of Soil Humic and Fulvic Acids on Germination and Early Growth of Native and Introduced Grass Varieties

    National Research Council Canada - National Science Library

    Senesi, Nicola

    2007-01-01

    The presence of humic acid (HA) generally affects positively and at various extent the germination and early growth of all varieties examined but in some cases negative effects are measured on the early growth...

  18. Time-Series Interactions of Gene Expression, Vascular Growth and Hemodynamics during Early Embryonic Arterial Development.

    Directory of Open Access Journals (Sweden)

    Selda Goktas

    Full Text Available The role of hemodynamic forces within the embryo as biomechanical regulators for cardiovascular morphogenesis, growth, and remodeling is well supported through the experimental studies. Furthermore, clinical experience suggests that perturbed flow disrupts the normal vascular growth process as one etiology for congenital heart diseases (CHD and for fetal adaptation to CHD. However, the relationships between hemodynamics, gene expression and embryonic vascular growth are poorly defined due to the lack of concurrent, sequential in vivo data. In this study, a long-term, time-lapse optical coherence tomography (OCT imaging campaign was conducted to acquire simultaneous blood velocity, pulsatile micro-pressure and morphometric data for 3 consecutive early embryonic stages in the chick embryo. In conjunction with the in vivo growth and hemodynamics data, in vitro reverse transcription polymerase chain reaction (RT-PCR analysis was performed to track changes in transcript expression relevant to histogenesis and remodeling of the embryonic arterial wall. Our non-invasive extended OCT imaging technique for the microstructural data showed continuous vessel growth. OCT data coupled with the PIV technique revealed significant but intermitted increases in wall shear stress (WSS between first and second assigned stages and a noticeable decrease afterwards. Growth rate, however, did not vary significantly throughout the embryonic period. Among all the genes studied, only the MMP-2 and CASP-3 expression levels remained unchanged during the time course. Concurrent relationships were obtained among the transcriptional modulation of the genes, vascular growth and hemodynamics-related changes. Further studies are indicated to determine cause and effect relationships and reversibility between mechanical and molecular regulation of vasculogenesis.

  19. Assessment of the effect of salinity on the early growth stage of the ...

    African Journals Online (AJOL)

    Assessment of the effect of salinity on the early growth stage of the common sunflower (Sanay cultivar) using spectral discrimination techniques. H Turhan, L Genc, SE Smith, YB Bostanci, OS Turkmen ...

  20. Reproduction and Growth in a Murine Model of Early Life-Onset Inflammatory Bowel Disease.

    Directory of Open Access Journals (Sweden)

    Eniko Nagy

    Full Text Available Studies in transgenic murine models have provided insight into the complexity underlying inflammatory bowel disease (IBD, a disease hypothesized to result from an injurious immune response against intestinal microbiota. We recently developed a mouse model of IBD that phenotypically and histologically resembles human childhood-onset ulcerative colitis (UC, using mice that are genetically modified to be deficient in the cytokines TNF and IL-10 ("T/I" mice. Here we report the effects of early life onset of colon inflammation on growth and reproductive performance of T/I mice. T/I dams with colitis often failed to get pregnant or had small litters with pups that failed to thrive. Production was optimized by breeding double homozygous mutant T/I males to females homozygous mutant for TNF deficiency and heterozygous for deficiency of IL-10 ("T/I-het" dams that were not susceptible to spontaneous colon inflammation. When born to healthy (T/I-het dams, T/I pups initially gained weight similarly to wild type (WT pups and to their non-colitis-susceptible T/I-het littermates. However, their growth curves diverged between 8 and 13 weeks, when most T/I mice had developed moderate to severe colitis. The observed growth failure in T/I mice occurred despite a significant increase in their food consumption and in the absence of protein loss in the stool. This was not due to TNF-induced anorexia or altered food consumption due to elevated leptin levels. Metabolic studies demonstrated increased consumption of oxygen and water and increased production of heat and CO2 in T/I mice compared to their T/I-het littermates, without differences in motor activity. Based on the clinical similarities of this early life onset model of IBD in T/I mice to human IBD, these results suggest that mechanisms previously hypothesized to explain growth failure in children with IBD require re-evaluation. The T/I mouse model may be useful for further investigation of such mechanisms and

  1. Haematology, serum biochemistry and growth performance of ...

    African Journals Online (AJOL)

    High performing does have the tendency of producing healthy kids with reasonable weight at birth compared to least performing does. A study was conducted to investigate the haematology, serum biochemistry and growth performance of grazing pregnant Kalahari Red does fed concentrate diets at three protein levels.

  2. Placental pathology in early intrauterine growth restriction associated with maternal hypertension.

    Science.gov (United States)

    Veerbeek, J H W; Nikkels, P G J; Torrance, H L; Gravesteijn, J; Post Uiterweer, E D; Derks, J B; Koenen, S V; Visser, G H A; Van Rijn, B B; Franx, A

    2014-09-01

    To identify key pathological characteristics of placentas from pregnancies complicated by early intrauterine growth restriction, and to examine their relations with maternal hypertensive disease and umbilical artery Doppler waveform abnormalities. Single-center retrospective cohort study of singleton pregnancies with abnormal umbilical artery Doppler flow patterns resulting in a live birth intrauterine growth restriction with or without hypertensive disease and pathological characteristics were compared between these various conditions according to predefined scoring criteria. Among 164 placentas studied, we found high rates of characteristic histopathological features that were associated with intrauterine growth restriction, including infarction (>5% in 42%), chronic villitis (21%), chronic chorioamnionitis (36%), membrane necrosis (20%), elevated nucleated red blood cells (89%), increased syncytial knotting (93%), increased villous maturation (98%), fetal thrombosis (32%) and distal villous hypoplasia (35%). Chronic inflammation of fetal membranes and syncytial knotting were more common in women with concomitant hypertensive disease as compared to women with normotensive IUGR (p < 0.05). Placentas from women with umbilical artery AREDF were more likely to show increased numbers of nucleated red blood cells and distal villous hypoplasia (p < 0.05). Placentas of women with early IUGR show high rates of several histological aberrations. Further, concomitant maternal hypertension is associated with characteristic inflammatory changes and umbilical artery AREDF with signs of chronic hypoxia. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. Early childhood neurodevelopment after intrauterine growth restriction: a systematic review.

    Science.gov (United States)

    Levine, Terri A; Grunau, Ruth E; McAuliffe, Fionnuala M; Pinnamaneni, RagaMallika; Foran, Adrienne; Alderdice, Fiona A

    2015-01-01

    Children who experienced intrauterine growth restriction (IUGR) may be at increased risk for adverse developmental outcomes in early childhood. The objective of this study was to carry out a systematic review of neurodevelopmental outcomes from 6 months to 3 years after IUGR. PubMed, Embase, PsycINFO, Maternity and Infant Care, and CINAHL databases were searched by using the search terms intrauterine, fetal, growth restriction, child development, neurodevelopment, early childhood, cognitive, motor, speech, language. Studies were eligible for inclusion if participants met specified criteria for growth restriction, follow-up was conducted within 6 months to 3 years, methods were adequately described, non-IUGR comparison groups were included, and full English text of the article was available. A specifically designed data extraction form was used. The methodological quality of included studies was assessed using well-documented quality-appraisal guidelines. Of 731 studies reviewed, 16 were included. Poorer neurodevelopmental outcomes after IUGR were described in 11. Ten found motor, 8 cognitive, and 7 language delays. Other delays included social development, attention, and adaptive behavior. Only 8 included abnormal Doppler parameters in their definitions of IUGR. Evidence suggests that children are at risk for poorer neurodevelopmental outcomes following IUGR from 6 months to 3 years of age. The heterogeneity of primary outcomes, assessment measures, adjustment for confounding variables, and definitions of IUGR limits synthesis and interpretation. Sample sizes in most studies were small, and some examined preterm IUGR children without including term IUGR or AGA comparison groups, limiting the value of extant studies. Copyright © 2015 by the American Academy of Pediatrics.

  4. Comparative growth performance of different Australian ...

    African Journals Online (AJOL)

    Comparative growth performance of different Australian provenances and local land ... and Ubiri in the West Usambara Mountains (WUM), North East Tanzania. ... with local land races for subsequent management as seed production stands.

  5. Production of Vibrio vulnificus metalloprotease VvpE begins during the early growth phase: usefulness of gelatin-zymography.

    Science.gov (United States)

    Kim, Choon-Mee; Kang, Sang-Mee; Jeon, Ho-Jong; Shin, Sung-Heui

    2007-07-01

    Recent studies have demonstrated that expression of the vvpE gene begins during the early growth phase albeit at low levels. However, we found that the traditional protease assay method that is used to measure caseinolytic activity in culture supernatants is not suitable for the measurement of extracellular VvpE that is produced at low levels during the early growth phase. By using gelatin-zymography in place of the protease assay, we could specifically detect only VvpE of several proteases produced by Vibrio vulnificus. Moreover, we could sensitively measure VvpE produced at low levels during the early growth phase, which was consistent with transcription of the vvpE gene. The extracellular production of VvpE was reduced or delayed by mutation of the pilD gene which encodes for the type IV leader peptidase/N-methyltransferase associated with the type II general secretion system; the delayed production of VvpE was recovered by in trans complementation of the wild-type pilD gene. These results indicate that VvpE begins to be produced during the early growth phase via the PilD-mediated type II general secretion system, and that the use of gelatin-zymography is recommended as a simple method for the sensitive and specific detection of VvpE production.

  6. Early math matters: kindergarten number competence and later mathematics outcomes.

    Science.gov (United States)

    Jordan, Nancy C; Kaplan, David; Ramineni, Chaitanya; Locuniak, Maria N

    2009-05-01

    Children's number competencies over 6 time points, from the beginning of kindergarten to the middle of 1st grade, were examined in relation to their mathematics achievement over 5 later time points, from the end of 1st grade to the end of 3rd grade. The relation between early number competence and mathematics achievement was strong and significant throughout the study period. A sequential process growth curve model showed that kindergarten number competence predicted rate of growth in mathematics achievement between 1st and 3rd grades as well as achievement level through 3rd grade. Further, rate of growth in early number competence predicted mathematics performance level in 3rd grade. Although low-income children performed more poorly than their middle-income counterparts in mathematics achievement and progressed at a slower rate, their performance and growth were mediated through relatively weak kindergarten number competence. Similarly, the better performance and faster growth of children who entered kindergarten at an older age were explained by kindergarten number competence. The findings show the importance of early number competence for setting children's learning trajectories in elementary school mathematics. Copyright 2009 APA, all rights reserved

  7. Early Math Matters: Kindergarten Number Competence and Later Mathematics Outcomes

    Science.gov (United States)

    Jordan, Nancy C.; Kaplan, David; Ramineni, Chaitanya; Locuniak, Maria N.

    2009-01-01

    Children’s number competencies over 6 time points, from the beginning of kindergarten to the middle of 1st grade, were examined in relation to their mathematics achievement over 5 later time points, from the end of 1st grade to the end of 3rd grade. The relation between early number competence and mathematics achievement was strong and significant throughout the study period. A sequential process growth curve model showed that kindergarten number competence predicted rate of growth in mathematics achievement between 1st and 3rd grades as well as achievement level through 3rd grade. Further, rate of growth in early number competence predicted mathematics performance level in 3rd grade. Although low-income children performed more poorly than their middle-income counterparts in mathematics achievement and progressed at a slower rate, their performance and growth were mediated through relatively weak kindergarten number competence. Similarly, the better performance and faster growth of children who entered kindergarten at an older age were explained by kindergarten number competence. The findings show the importance of early number competence for setting children’s learning trajectories in elementary school mathematics. PMID:19413436

  8. Intelligence in early adulthood and midlife physical performance in men

    DEFF Research Database (Denmark)

    Meincke, Rikke Hodal; Hansen, Åse Marie; Mortensen, Laust Hvas

    2016-01-01

    The objective of this study was to examine whether associations between intelligence in early adulthood and midlife physical performance in men were mediated by education and leisure-time physical activity. Intelligence correlated positively with later education (r = 0.47) and negatively with phy......The objective of this study was to examine whether associations between intelligence in early adulthood and midlife physical performance in men were mediated by education and leisure-time physical activity. Intelligence correlated positively with later education (r = 0.47) and negatively...... performance, but because intelligence in early adulthood was inversely associated with physical activity, the indirect effects through physical activity were negative. Overall, education and leisure-time physical activity were not strong mediators of the association between early adult intelligence...

  9. Effect of feeding frequencies on growth performance of Clarias ...

    African Journals Online (AJOL)

    Effect of feeding frequencies on growth performance of Clarias gariepinus. CI Ayo-Olalusi, AAA Ugwumba. Abstract. Investigations were carried out on the growth performance of juvenile Clarias gariepinus using four different feeding frequencies. Two hundred and forty juveniles (8.6 +0.0 g) were stocked in eight aquaria ...

  10. Early nutrition and its effect on growth, body composition and later obesity

    DEFF Research Database (Denmark)

    Eriksen, Kamilla Gehrt; Lind, Mads Vendelbo; Larnkjær, Anni

    2018-01-01

    and body composition as outcome measures in countries where obesity and related diseases in later life is a large public health problem. For this short review, we have included 10 publications on the topic of early nutrition and its effect on growth, body composition, and later obesity. We think these 10......Adequate nutrition in the first 2 years of life is essential for both short- and long-term health. Malnutrition in the early years of life increases the risk of later chronic diseases. There is a wealth of studies available within this area of research, and this chapter specifically looks at growth...... included publications, published during the period of July 1, 2016 to June 30, 2017, are of special interest and all present findings can shape future research on this topic. We have chosen to focus on 3 key areas in this review; (i) human milk composition, including studies on breast milk minerals...

  11. Catch-Up Growth Occurs after Diarrhea in Early Childhood123

    Science.gov (United States)

    Richard, Stephanie A.; Black, Robert E.; Gilman, Robert H.; Guerrant, Richard L.; Kang, Gagandeep; Lanata, Claudio F.; Mølbak, Kåre; Rasmussen, Zeba A.; Sack, R. Bradley; Valentiner-Branth, Palle; Checkley, William

    2014-01-01

    Diarrhea and linear growth faltering continue to burden low-income countries and are among the most important contributors to poor health during early childhood. Diarrhea is thought to adversely affect linear growth, but catch-up growth can occur if no additional insults are experienced. We sought to characterize catch-up growth in relation to diarrhea burden in a multisite dataset of 1007 children. Using longitudinal anthropometry and diarrheal surveillance data from 7 cohort studies in 4 countries, we examined the relation between diarrhea prevalence and growth in 3- to 6-mo periods using linear mixed-effect models. Growth during each period was calculated as a function of age using linear splines. We incorporated the longitudinal prevalence of diarrhea in both current and previous periods into the model. Diarrhea during the current period was associated with slower linear and ponderal growth. Faster (catch-up) growth in length was observed in children with no diarrhea in age groups immediately after an age group in which diarrhea was experienced [age group >6–12 mo: 0.03 mm/mo for each percentage diarrhea prevalence in the previous period (95% CI: 0.007, 0.06) relative to 11.3 mm/mo mean growth rate; age group >12–18 mo: 0.04 mm/mo (95% CI: 0.02, 0.06) relative to 8.9 mm/mo mean growth rate; age group >18–24 mo: 0.04 mm/mo (95% CI: 0.003, 0.09) relative to 7.9 mm/mo mean growth rate]. The associations were stronger in boys than in girls when separate models were run. Similar results were observed when weight was the outcome variable. When diarrheal episodes are followed by diarrhea-free periods in the first 2 y of life, catch-up growth is observed that may allow children to regain their original trajectories. The finding of a greater effect of diarrhea on linear growth in boys than in girls was unexpected and requires additional study. Diarrhea burdens are high throughout the first 2 y of life in these study sites, therefore reducing the likelihood of

  12. Growth recovery and faltering through early adolescence in low- and middle-income countries: Determinants and implications for cognitive development.

    Science.gov (United States)

    Georgiadis, Andreas; Benny, Liza; Duc, Le Thuc; Galab, Sheikh; Reddy, Prudhvikar; Woldehanna, Tassew

    2017-04-01

    Child chronic undernutrition, as measured by stunting, is prevalent in low- and middle-income countries and is among the major threats to child development. While stunting and its implications for cognitive development have been considered irreversible beyond early childhood there is a lack of consensus in the literature on this, as there is some evidence of recovery from stunting and that this recovery may be associated with improvements in cognition. Less is known however, about the drivers of growth recovery and the aspects of recovery linked to cognitive development. In this paper we investigate the factors associated with growth recovery and faltering through age 12 years and the implications of the incidence, timing, and persistence of post-infancy recovery from stunting for cognitive development using longitudinal data from Ethiopia, India, Peru, and Vietnam. We find that the factors most systematically associated with accelerated growth both before and after early childhood and across countries include mother's height, household living standards and shocks, community wages, food prices, and garbage collection. Our results suggest that post-infancy recovery from stunting is more likely to be systematically associated with higher achievement scores across countries when it is persistent and that associations between growth trajectories and cognitive achievement in middle childhood do not persist through early adolescence across countries. Overall, our findings indicate that growth after early childhood is responsive to changes in the household and community environments and that growth promotion after early childhood may yield improvements in child cognitive development. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. Early Arabidopsis root hair growth stimulation by pathogenic strains of Pseudomonas syringae.

    Science.gov (United States)

    Pecenková, Tamara; Janda, Martin; Ortmannová, Jitka; Hajná, Vladimíra; Stehlíková, Zuzana; Žárský, Viktor

    2017-09-01

    Selected beneficial Pseudomonas spp. strains have the ability to influence root architecture in Arabidopsis thaliana by inhibiting primary root elongation and promoting lateral root and root hair formation. A crucial role for auxin in this long-term (1week), long-distance plant-microbe interaction has been demonstrated. Arabidopsis seedlings were cultivated in vitro on vertical plates and inoculated with pathogenic strains Pseudomonas syringae pv. maculicola (Psm) and P. syringae pv. tomato DC3000 (Pst), as well as Agrobacterium tumefaciens (Atu) and Escherichia coli (Eco). Root hair lengths were measured after 24 and 48h of direct exposure to each bacterial strain. Several Arabidopsis mutants with impaired responses to pathogens, impaired ethylene perception and defects in the exocyst vesicle tethering complex that is involved in secretion were also analysed. Arabidopsis seedling roots infected with Psm or Pst responded similarly to when infected with plant growth-promoting rhizobacteria; root hair growth was stimulated and primary root growth was inhibited. Other plant- and soil-adapted bacteria induced similar root hair responses. The most compromised root hair growth stimulation response was found for the knockout mutants exo70A1 and ein2. The single immune pathways dependent on salicylic acid, jasmonic acid and PAD4 are not directly involved in root hair growth stimulation; however, in the mutual cross-talk with ethylene, they indirectly modify the extent of the stimulation of root hair growth. The Flg22 peptide does not initiate root hair stimulation as intact bacteria do, but pretreatment with Flg22 prior to Psm inoculation abolished root hair growth stimulation in an FLS2 receptor kinase-dependent manner. These early response phenomena are not associated with changes in auxin levels, as monitored with the pDR5::GUS auxin reporter. Early stimulation of root hair growth is an effect of an unidentified component of living plant pathogenic bacteria. The root

  14. Growth performance of broilers in experimental Reovirus infections

    Directory of Open Access Journals (Sweden)

    Sudhakar P. Awandkar

    Full Text Available Background: The avian reoviruses have emerged to induce various manifestations in chickens. They are associated with disease conditions including malabsorption syndrome, tenosynovitis etc. Reoviruses are an important cause of suboptimum performance in broilers, resulting in poor growth performance. Poultry industry in India is facing a catastrophe due to such infections which go unnoticed in field due to masking of the symptoms by secondary infections and commonly observed nutritional disorders. Aim: To investigate the effect of reovirus infection on overall performance of broiler birds. Material and Methods: The broiler birds were challenged with homologous strains of malabsorption syndrome and tenosynovitis syndrome of reovirus. The growth performance was recorded. Results and conclusion: The growth performance and immune response to NDV did not differ in the birds challenged with tenosynovitis syndrome strain of reo virus as compared to un challenged birds. However, poor live body weight, feed intake, FCR, PE and BPEI and better serum NDV titres were found in chicks challenged with malabsorption syndrome strain of reovirus as compared to the chicks from control group. [Vet World 2012; 5(11.000: 685-689

  15. Growth performance, carcass and hematological characteristics of ...

    African Journals Online (AJOL)

    Growth performance, carcass and hematological characteristics of rabbits fed graded levels of tiger nuts ( Cyperus esculentus ) ... (p>0.05) difference between treatments. Results demonstrated that (Cyperus esculentus) could be used up to 5% in rabbit's diets without adverse effect on the animals' performance and health.

  16. Effect of drought stress on early growth of Adansonia digitata (L.) in ...

    African Journals Online (AJOL)

    Drought and high temperatures are said to have triggered increased tree mortality and could be linked to the menace of climate change. This research therefore investigated the effect of drought stress on early growth of Adansonia digitata where seedlings were exposed to different watering frequencies (Once daily, after 3, ...

  17. Early Specialization in Youth Sport: A Biomechanical Perspective

    Science.gov (United States)

    Mattson, Jeffrey M.; Richards, Jim

    2010-01-01

    This article examines, from a biomechanical perspective, three issues related to early specialization: overuse injuries, the developmental aspects, and the performance aspects. It concludes that "there is no evidence that early specialization causes overuse injuries or hinders growth and maturation." At the same time, early specialization has…

  18. How are arbuscular mycorrhizal associations related to maize growth performance during short-term cover crop rotation?

    Science.gov (United States)

    Higo, Masao; Takahashi, Yuichi; Gunji, Kento; Isobe, Katsunori

    2018-03-01

    Better cover crop management options aiming to maximize the benefits of arbuscular mycorrhizal fungi (AMF) to subsequent crops are largely unknown. We investigated the impact of cover crop management methods on maize growth performance and assemblages of AMF colonizing maize roots in a field trial. The cover crop treatments comprised Italian ryegrass, wheat, brown mustard and fallow in rotation with maize. The diversity of AMF communities among cover crops used for maize management was significantly influenced by the cover crop and time course. Cover crops did not affect grain yield and aboveground biomass of subsequent maize but affected early growth. A structural equation model indicated that the root colonization, AMF diversity and maize phosphorus uptake had direct strong positive effects on yield performance. AMF variables and maize performance were related directly or indirectly to maize grain yield, whereas root colonization had a positive effect on maize performance. AMF may be an essential factor that determines the success of cover crop rotational systems. Encouraging AMF associations can potentially benefit cover cropping systems. Therefore, it is imperative to consider AMF associations and crop phenology when making management decisions. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  19. Root and aerial growth in early-maturing peach trees under two crop load treatments

    Energy Technology Data Exchange (ETDEWEB)

    Abrisqueta, I.; Conejero, W.; López-Martínez, L.; Vera, J.; Ruiz Sánchez, M.C.

    2017-07-01

    The objectives of the paper were to study the pattern of root growth (measured by minirhizotrons) in relation to trunk, fruit and shoot growth and the effects of crop load on tree growth and yield in peach trees. Two crop load (commercial and low) treatments were applied in a mature early-maturing peach tree orchard growing in Mediterranean conditions. Root growth dynamics were measured using minirhizotrons during one growing season. Shoot, trunk and fruit growth were also measured. At harvest, all fruits were weighed, counted and sized. Roots grew throughout the year but at lower rates during the active fruit growth phase. Root growth was asynchronous with shoot growth, while root and trunk growth rates were highest after harvest, when the canopy was big enough to allocate the photo-assimilates to organs that would ensure the following season’s yield. Shoot and fruit growth was greater in the low crop load treatment and was accompanied by a non-significant increase in root growth. High level of fruit thinning decreased the current yield but the fruits were more marketable because of their greater size.

  20. Pathways of early fatherhood, marriage, and employment: a latent class growth analysis.

    Science.gov (United States)

    Dariotis, Jacinda K; Pleck, Joseph H; Astone, Nan M; Sonenstein, Freya L

    2011-05-01

    In the National Longitudinal Survey of Youth 1979 (NLSY79), young fathers include heterogeneous subgroups with varying early life pathways in terms of fatherhood timing, the timing of first marriage, and holding full-time employment. Using latent class growth analysis with 10 observations between ages 18 and 37, we derived five latent classes with median ages of first fatherhood below the cohort median (26.4), constituting distinct early fatherhood pathways representing 32.4% of NLSY men: (A) Young Married Fathers, (B) Teen Married Fathers, (C) Young Underemployed Married Fathers, (D) Young Underemployed Single Fathers, and (E) Young Later-Marrying Fathers. A sixth latent class of men who become fathers around the cohort median, following full-time employment and marriage (On-Time On-Sequence Fathers), is the comparison group. With sociodemographic background controlled, all early fatherhood pathways show disadvantage in at least some later-life circumstances (earnings, educational attainment, marital status, and incarceration). The extent of disadvantage is greater when early fatherhood occurs at relatively younger ages (before age 20), occurs outside marriage, or occurs outside full-time employment. The relative disadvantage associated with early fatherhood, unlike early motherhood, increases over the life course.

  1. COMPENSATORY GROWTH AND FAT PARAMETERS ON BROILER FASTED IN EARLY LIFE

    Directory of Open Access Journals (Sweden)

    S. Sugiharto

    2014-10-01

    Full Text Available The experiment was carried out to investigate the effect of feed withholding in the very early life ofbird on its compensatory growth capacity and fat parameters. A total of 60 mixed-sexes of one day oldRoss chicks were used in the experiment conducted with completely randomized design of 2 differentfeeding times after hatching, i.e.: T1: given access to feed and water ad libitum immediately afterhatching until 35d of age; and T2: withheld from feed (fasted but not from water for 48h after hatchingand then fed ad libitum until d35. The birds were weighed at the start of experiment and weeklythereafter, and DWG was then calculated. Feed intakes and FCR were also recorded weekly. At d36,abdominal fat was taken out from 2 birds per pen and was weighed. Breast meat (skinless from thesame birds was also sampled for total FA analysis. Final BW (d35 and total feed consumption of earlyfastedbirds were 1935.17±43.90 kg and 2745.55±47.48 kg and those of unfasted birds were2019.00±50.85 kg and 2910.84±128.10 kg, respectively. FCR of early-fasted and unfasted birds at d35were 1.42±0.03 and 1.45±0.07. The magnitude difference of DWG between early-fasted and unfastedbirds was 27% at d7, whereas at d35 the difference was only 4.5%. Abdominal fat percentage to live BWof early-fasted birds was 1.65±0.09% (male and 1.60±0.10% (female and that of unfasted birds was2.00±0.19% (male and 1.89±0.38% (female. Total FA contained in meat of early-fasted and unfastedbirds were 0.82±0.10 and 0.85±0.10 g/100gDM. Overall, BW and feed consumption of early-fastedbirds were significantly lower (P<0.05 than unfasted birds. DWG, FCR, abdominal fat and total FAcontained in meat were not significantly different (P>0.05 between early-fasted and unfasted birds. Inconclusion, holding birds without feed following hatch (under practical conditions may limit thecompensatory growth capacity of birds in the later age. Fasting applied in the very early life of broilerleads to

  2. A Growth Curve Analysis of Literacy Performance among Second-Grade, Spanish-Speaking, English-Language Learners

    Science.gov (United States)

    Gutiierrez, Gabriel; Vanderwood, Mike L.

    2013-01-01

    The literacy growth of 260 second-grade English learners (ELs) with varying degrees of English language proficiency (e.g., Beginning, Early Intermediate, Intermediate, Early Advanced and Advanced English language proficiency) was assessed with English literacy skill assessments. Dynamic Indicators of Basic Early Literacy Skills measures were…

  3. Examining the Predictive Relations between Two Aspects of Self-Regulation and Growth in Preschool Children’s Early Literacy Skills

    Science.gov (United States)

    Lonigan, Christopher J.; Allan, Darcey M.; Phillips, Beth M.

    2016-01-01

    There is strong evidence that self-regulatory processes are linked to early academic skills both concurrently and longitudinally. The majority of extant longitudinal studies, however, have been conducted using autoregressive techniques that may not accurately model change across time. The purpose of this study was to examine the unique associations between two components of self-regulation, attention and executive functioning (EF), and growth in early literacy skills over the preschool year using latent-growth-curve analysis. The sample included 1,082 preschool children (M-age = 55.0 months, SD = 3.73). Children completed measures of vocabulary, syntax, phonological awareness, print knowledge, cognitive ability, and self-regulation, and children’s classroom teachers completed a behavior rating measure. To examine the independent relations of the self-regulatory skills and cognitive ability with children’s initial early literacy skills and growth across the preschool year, growth models in which the intercept and slope were simultaneously regressed on each of the predictor variables were examined. Because of the significant relation between intercept and slope for most outcomes, slope was regressed on intercept in the models to allow a determination of direct and indirect effects of the predictors on growth in children’s language and literacy skills across the preschool year. In general, both teacher-rated inattention and directly measured EF were uniquely associated with initial skills level; however, only teacher-rated inattention uniquely predicted growth in early literacy skills. These findings suggest that teacher-ratings of inattention may measure an aspect of self-regulation that is particularly associated with the acquisition of academic skills in early childhood. PMID:27854463

  4. Polychlorinated dibenzo-p-dioxins, furans, and biphenyls (PCDDs/PCDFs and PCBs) in breast milk and early childhood growth and IGF1

    DEFF Research Database (Denmark)

    Wohlfahrt-Veje, Christine; Audouze, Karine Marie Laure; Brunak, Søren

    2014-01-01

    Experimental studies have shown that dioxin-like chemicals may interfere with aspects of the endocrine system including growth. However, human background population studies are, however, scarce. We aimed to investigate whether early exposure of healthy infants to dioxin-like chemicals...... was associated with changes in early childhood growth and serum IGF1. In 418 maternal breast milk samples of Danish children (born 1997-2001) from a longitudinal cohort, we measured polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls (pg or ng/g lipid) and calculated...... to dioxin-like chemicals was associated with being skinny at birth and with higher infant levels of circulating IGF1 as well as accelerated early childhood growth (rapid catch-up growth)....

  5. Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction.

    Science.gov (United States)

    Illa, Miriam; Brito, Verónica; Pla, Laura; Eixarch, Elisenda; Arbat-Plana, Ariadna; Batallé, Dafnis; Muñoz-Moreno, Emma; Crispi, Fatima; Udina, Esther; Figueras, Francesc; Ginés, Silvia; Gratacós, Eduard

    2017-10-12

    The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abnormalities in an IUGR rabbit model and the effects of early postnatal environmental enrichment (EE) were explored. IUGR was surgically induced in one horn, whereas the contralateral one produced the controls. Postnatally, a subgroup of IUGR animals was housed in an enriched environment. Functional assessment was performed at the neonatal and long-term periods. At the long-term period, structural brain connectivity was evaluated by means of diffusion-weighted brain magnetic resonance imaging and by histological assessment focused on the hippocampus. IUGR animals displayed poorer functional results and presented altered whole-brain networks and decreased median fractional anisotropy in the hippocampus. Reduced density of dendritic spines and perineuronal nets from hippocampal neurons were also observed. Of note, IUGR animals exposed to enriched environment presented an improvement in terms of both function and structure. IUGR is associated with altered brain connectivity at the global and cellular level. A strategy based on early EE has the potential to restore the neurodevelopmental consequences of IUGR. © 2017 S. Karger AG, Basel.

  6. Impacts of parasites in early life: contrasting effects on juvenile growth for different family members.

    Directory of Open Access Journals (Sweden)

    Thomas E Reed

    Full Text Available Parasitism experienced early in ontogeny can have a major impact on host growth, development and future fitness, but whether siblings are affected equally by parasitism is poorly understood. In birds, hatching asynchrony induced by hormonal or behavioural mechanisms largely under parental control might predispose young to respond to infection in different ways. Here we show that parasites can have different consequences for offspring depending on their position in the family hierarchy. We experimentally treated European Shag (Phalacrocorax aristoteli nestlings with the broad-spectrum anti-parasite drug ivermectin and compared their growth rates with nestlings from control broods. Average growth rates measured over the period of linear growth (10 days to 30 days of age and survival did not differ for nestlings from treated and control broods. However, when considering individuals within broods, parasite treatment reversed the patterns of growth for individual family members: last-hatched nestlings grew significantly slower than their siblings in control nests but grew faster in treated nests. This was at the expense of their earlier-hatched brood-mates, who showed an overall growth rate reduction relative to last-hatched nestlings in treated nests. These results highlight the importance of exploring individual variation in the costs of infection and suggest that parasites could be a key factor modulating within-family dynamics, sibling competition and developmental trajectories from an early age.

  7. Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth.

    Directory of Open Access Journals (Sweden)

    Agnes Bonnet

    Full Text Available The successful achievement of early ovarian folliculogenesis is important for fertility and reproductive life span. This complex biological process requires the appropriate expression of numerous genes at each developmental stage, in each follicular compartment. Relatively little is known at present about the molecular mechanisms that drive this process, and most gene expression studies have been performed in rodents and without considering the different follicular compartments.We used RNA-seq technology to explore the sheep transcriptome during early ovarian follicular development in the two main compartments: oocytes and granulosa cells. We documented the differential expression of 3,015 genes during this phase and described the gene expression dynamic specific to these compartments. We showed that important steps occurred during primary/secondary transition in sheep. We also described the in vivo molecular course of a number of pathways. In oocytes, these pathways documented the chronology of the acquisition of meiotic competence, migration and cellular organization, while in granulosa cells they concerned adhesion, the formation of cytoplasmic projections and steroid synthesis. This study proposes the involvement in this process of several members of the integrin and BMP families. The expression of genes such as Kruppel-like factor 9 (KLF9 and BMP binding endothelial regulator (BMPER was highlighted for the first time during early follicular development, and their proteins were also predicted to be involved in gene regulation. Finally, we selected a data set of 24 biomarkers that enabled the discrimination of early follicular stages and thus offer a molecular signature of early follicular growth. This set of biomarkers includes known genes such as SPO11 meiotic protein covalently bound to DSB (SPO11, bone morphogenetic protein 15 (BMP15 and WEE1 homolog 2 (S. pombe(WEE2 which play critical roles in follicular development but other biomarkers

  8. Fertility, hatchability and growth performance of native and ...

    African Journals Online (AJOL)

    Fertility and hatchability serve as measures of genetic and reproductive fitness of individual bird. These two along with growth performance are important yardsticks in evaluating the economic efficiency of parent stocks. There is no previous study on the evaluation of Goliath and Sussex chickens for hatchability, growth and ...

  9. What Determines the Growth Ambition of Dutch Early-Stage Entrepreneurs?

    OpenAIRE

    Ingrid Verheul; Linda van Mil

    2008-01-01

    This paper investigates the determinants of the ambition to grow among Dutch early-stage entrepreneurs (nascents and young business owners). We use Adult Population Survey data of the Global Entrepreneurship Monitor (GEM) for the Netherlands. Merging cross-sectional data of the years 2002 to 2007, we arrive at a sample of 409 nascents and 336 young business owners. Growth ambition is measured by asking the respondent which statement fits him or her best: (1) I want my company to be as large a...

  10. Azolla pinnata growth performance in different water sources.

    Science.gov (United States)

    Nordiah, B; Harah, Z Muta; Sidik, B Japar; Hazma, W N Wan

    2012-07-01

    Azolla pinnata R.Br. growth performance experiments in different water sources were conducted from May until July 2011 at Aquaculture Research Station, Puchong, Malaysia. Four types of water sources (waste water, drain water, paddy field water and distilled water) each with different nutrient contents were used to grow and evaluate the growth performance of A. pinnata. Four water sources with different nutrient contents; waste, drain, paddy and distilled water as control were used to evaluate the growth performance of A. pinnata. Generally, irrespective of the types of water sources there were increased in plant biomass from the initial biomass (e.g., after the first week; lowest 25.2% in distilled water to highest 133.3% in drain water) and the corresponding daily growth rate (3.61% in distilled water to 19.04% in drain water). The increased in biomass although fluctuated with time was consistently higher in drain water compared to increased in biomass for other water sources. Of the four water sources, drain water with relatively higher nitrate concentration (0.035 +/- 0.003 mg L(-l)) and nitrite (0.044 +/- 0.005 mg L(-1)) and with the available phosphate (0.032 +/- 0.006 mg L(-1)) initially provided the most favourable conditions for Azolla growth and propagation. Based on BVSTEP analysis (PRIMER v5), the results indicated that a combination of more than one nutrient or multiple nutrient contents explained the observed increased in biomass of A. pinnata grown in the different water sources.

  11. Early development and growth of sterlet (Acipenser ruthenus) in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Rybnikár, J.; Prokeš, Miroslav; Mareš, J.; Cileček, M.

    2011-01-01

    Roč. 59, č. 5 (2011), s. 217-225 ISSN 1211-8516 R&D Projects: GA MZe QH71305 Institutional research plan: CEZ:AV0Z60930519 Keywords : early ontogeny * specific growth rate * length-weight relationship * factor of weight condition Subject RIV: GL - Fishing http://www.mendelu.cz/dok_server/slozka.pl?id=51329;download=82072

  12. Arbuscular mycorrhiza contribution to the growth performance and ...

    African Journals Online (AJOL)

    hope&shola

    2009-06-12

    Jun 12, 2009 ... performance and heavy metal uptake of Helianthus ... growth performance and heavy metals (Cd and Pb) uptake of Helianthus annuus L. from polluted soils. Cadmium sulfate ..... Phytoextraction of Toxic Metals: A review of.

  13. Early maternal depressive symptoms and child growth trajectories: a longitudinal analysis of a nationally representative US birth cohort

    OpenAIRE

    Surkan, Pamela J; Ettinger, Anna K; Hock, Rebecca S; Ahmed, Saifuddin; Strobino, Donna M; Minkovitz, Cynthia S

    2014-01-01

    Background: Maternal depressive symptoms are negatively associated with early child growth in developing countries; however, few studies have examined this relation in developed countries or used a longitudinal design with data past the second year of the child’s life. We investigated if and when early maternal depressive symptoms affect average growth in young children up to age 6 in a nationally representative sample of US children. Methods: Using data from 6,550 singleton births from the E...

  14. An early feeding regime and a high-density amino acid diet on growth performance of broilers under subclinical necrotic enteritis challenge

    OpenAIRE

    Chake Keerqin; Shu-Biao Wu; Birger Svihus; Robert Swick; Natalie Morgan; Mingan Choct

    2017-01-01

    Broilers that have early access to feed have been shown to have enhanced immune system and gut development and heightened resilience against necrotic enteritis (NE). This study examined the effect of early feeding a high amino acid density diet on performance of broilers under a sub-clinical NE challenge model. Ross 308 broilers (n = 576) were assigned to a 2 × 2 × 2 factorial design with 2 feeding regimes (feed access either within 6 h post-hatch or after 48 h post-hatch), 2 diets (control d...

  15. Early Life Factors and Inter-Country Heterogeneity in BMI Growth Trajectories of European Children: The IDEFICS Study.

    Directory of Open Access Journals (Sweden)

    Claudia Börnhorst

    Full Text Available Starting from birth, this explorative study aimed to investigate between-country differences in body mass index (BMI trajectories and whether early life factors explain these differences.The sample included 7,644 children from seven European countries (Belgium, Cyprus, Germany, Hungary, Italy, Spain, Sweden participating in the multi-centre IDEFICS study. Information on early life factors and in total 53,409 repeated measurements of height and weight from 0 to <12 years of age were collected during the baseline (2007/2008 and follow-up examination (2009/2010 supplemented by records of routine child health visits. Country-specific BMI growth curves were estimated using fractional polynomial mixed effects models. Several covariates focussing on early life factors were added to the models to investigate their role in the between-countries differences.Large between-country differences were observed with Italian children showing significantly higher mean BMI values at all ages ≥ 3 years compared to the other countries. For instance, at age 11 years mean BMI values in Italian boys and girls were 22.3 [21.9;22.8; 99% confidence interval] and 22.0 [21.5;22.4], respectively, compared to a range of 18.4 [18.1;18.8] to 20.3 [19.8;20.7] in boys and 18.2 [17.8;18.6] to 20.3 [19.8;20.7] in girls in the other countries. After adjustment for early life factors, differences between country-specific BMI curves became smaller. Maternal BMI was the factor being most strongly associated with BMI growth (p<0.01 in all countries with associations increasing during childhood. Gestational weight gain (GWG was weakly associated with BMI at birth in all countries. In some countries, positive associations between BMI growth and children not being breastfed, mothers' smoking during pregnancy and low educational level of parents were found.Early life factors seem to explain only some of the inter-country variation in growth. Maternal BMI showed the strongest association

  16. The Groove of Growth: How Early Gains in Math Ability Influence Adolescent Achievement

    Science.gov (United States)

    Watts, Tyler W.; Duncan, Greg J.; Siegler, Robert S.; Davis-Kean, Pamela E.

    2014-01-01

    A number of studies, both small scale and of nationally-representative student samples, have reported substantial associations between school entry math ability and later elementary school achievement. However, questions remain regarding the persistence of the association between early growth in math ability and later math achievement due to the…

  17. Modeling of thin films growth processes in the early stage for atoms with covalent bonds

    International Nuclear Information System (INIS)

    Tupik, V A; Margolin, V I; Su, Chu Trong

    2017-01-01

    Computer simulation for obtaining thin film’s growth process at an early stage with the proposed model of atoms with isotropic and anisotropic interactions been considered. Carrying out the procedure for analyzing the problem on the basis of the program being implemented, computer simulation of thin film growth processes has been carried out on several examples. The results of computer simulation of the growth process of thin film on a given substrate and an aggregate in a vacuum condition are shown. Some characteristic distributions of the obtained structure have been carried out to evaluate the proposed adequate model and to reflect the high complexity of thin films growth process. (paper)

  18. EVERREST prospective study: a 6-year prospective study to define the clinical and biological characteristics of pregnancies affected by severe early onset fetal growth restriction.

    Science.gov (United States)

    Spencer, Rebecca; Ambler, Gareth; Brodszki, Jana; Diemert, Anke; Figueras, Francesc; Gratacós, Eduard; Hansson, Stefan R; Hecher, Kurt; Huertas-Ceballos, Angela; Marlow, Neil; Marsál, Karel; Morsing, Eva; Peebles, Donald; Rossi, Carlo; Sebire, Neil J; Timms, John F; David, Anna L

    2017-01-23

    Fetal growth restriction (FGR) is a serious obstetric condition for which there is currently no treatment. The EVERREST Prospective Study has been designed to characterise the natural history of pregnancies affected by severe early onset FGR and establish a well phenotyped bio-bank. The findings will provide up-to-date information for clinicians and patients and inform the design and conduct of the EVERREST Clinical Trial: a phase I/IIa trial to assess the safety and efficacy of maternal vascular endothelial growth factor (VEGF) gene therapy in severe early onset FGR. Data and samples from the EVERREST Prospective Study will be used to identify ultrasound and/or biochemical markers of prognosis in pregnancies with an estimated fetal weight (EFW) economic impact; psychological impact; neonatal condition, progress and complications; and infant growth and neurodevelopment to 2 years of corrected age in surviving infants. Standardised longitudinal ultrasound measurements are performed, including: fetal biometry; uterine artery, umbilical artery, middle cerebral artery, and ductus venosus Doppler velocimetry; and uterine artery and umbilical vein volume blood flow. Samples of maternal blood and urine, amniotic fluid (if amniocentesis performed), placenta, umbilical cord blood, and placental bed (if caesarean delivery performed) are collected for bio-banking. An initial analysis of maternal blood samples at enrolment is planned to identify biochemical markers that are predictors for fetal or neonatal death. The findings of the EVERREST Prospective Study will support the development of a novel therapy for severe early onset FGR by describing in detail the natural history of the disease and by identifying women whose pregnancies have the poorest outcomes, in whom a therapy might be most advantageous. The findings will also enable better counselling of couples with affected pregnancies, and provide a valuable resource for future research into the causes of FGR. NCT02097667

  19. Accelerated fetal growth in early pregnancy and risk of severe large-for-gestational-age and macrosomic infant: a cohort study in a low-risk population.

    Science.gov (United States)

    Simic, Marija; Wikström, Anna-Karin; Stephansson, Olof

    2017-10-01

    Our objective was to examine the association between fetal growth in early pregnancy and risk of severe large-for-gestational-age (LGA) and macrosomia at birth in a low-risk population. Cohort study that included 68 771 women with non-anomalous singleton pregnancies, without history of diabetes or hypertension, based on an electronic database on pregnancies and deliveries in Stockholm-Gotland Region, Sweden, 2008-2014. We performed multivariable logistic regression to estimate the association between accelerated fetal growth occurring in the first through early second trimester as measured by ultrasound and LGA and macrosomia at birth. Restricted analyses were performed in the groups without gestational diabetes and with normal body mass index (18.5-24.9 kg/m 2 ). When adjusting for confounders, the odds of having a severely LGA or macrosomic infant were elevated in mothers with fetuses that were at least 7 days larger than expected as compared with mothers without age discrepancy at the second-trimester scan (adjusted odds ratio 1.80; 95% CI 1.23-2.64 and adjusted odds ratio 2.15; 95% CI 1.55-2.98, respectively). Additionally, mothers without gestational diabetes and mothers with normal weight had an elevated risk of having a severely LGA or macrosomic infant when the age discrepancy by second-trimester ultrasound was at least 7 days. In a low-risk population, ultrasound-estimated accelerated fetal growth in early pregnancy was associated with an increased risk of having a severely LGA or macrosomic infant. © 2017 Nordic Federation of Societies of Obstetrics and Gynecology.

  20. Determinants of Growth, Adiposity and Bone Mass in Early Life : The Generation R Study

    NARCIS (Netherlands)

    D.H.M. Heppe (Denise)

    2016-01-01

    markdownabstractAbstract Environmental influences during fetal life and early infancy have been suggested to influence body composition throughout the life-course. Especially poor fetal nutrition and fetal growth restriction have been designated important risk factors for gaining high fat mass

  1. Is Fetal Growth Restriction Associated with a More Severe Maternal Phenotype in the Setting of Early Onset Pre-Eclampsia? A Retrospective Study

    Science.gov (United States)

    Weiler, Jane; Tong, Stephen; Palmer, Kirsten R.

    2011-01-01

    Background Both pre-eclampsia and fetal growth restriction are thought to result from abnormal placental implantation in early pregnancy. Consistent with this shared pathophysiology, it is not uncommon to see growth restriction further confound the course of pre-eclampsia and vice versa. It has been previously suggested that superimposed growth restriction is associated with a more severe pre-eclamptic phenotype, however this has not been a consistent finding. Therefore, we set out to determine whether the presence of fetal growth restriction among women with severe early-onset pre-eclampsia was associated with more severe maternal disease compared to those without a growth-restricted fetus. Methods and Findings We undertook a retrospective cohort study of women presenting to a tertiary hospital with severe early-onset pre-eclampsia (restriction. However, no significant difference was seen in relation to the severity of pre-eclampsia between those with or without a growth-restricted baby. The presence of concomitant growth restriction was however associated with a significantly increased risk of stillbirth (p = 0.003) and total perinatal mortality (p = 0.02). Conclusions The presence of fetal growth restriction among women with severe early-onset pre-eclampsia is not associated with increased severity of maternal disease. However the incidence of stillbirth and perinatal death is significantly increased in this sub-population. PMID:22046419

  2. Performance Agent Groups in the Promotion of Smart Economic Growth

    Directory of Open Access Journals (Sweden)

    Krūzmētra Maiga

    2017-12-01

    Full Text Available Any country is interested in economic growth regardless of its development level in any period; yet an increasingly important role in defining growth is played by the term ‘smart growth’. The EU development strategy until 2020 defines smart growth as a strategic objective. Smart growth does not take place automatically. It is affected both by the condition of the economic, social and natural environments and by subjective factors - the competence of performance agents. The present research distinguished three groups of rural space and regional performance agents: national institutions, local governments and communities of residents of the territories examined by the research. The research summarised the opinions of experts (Latvia n=171; Lithuania n=163 from the south-eastern part of Latvia and the north-eastern part of Lithuania with the purpose of assessing the contribution of the performance agent groups to the promotion of smart economic growth. The research aimed to identify the positive indications of the contribution made by each performance agent group as well as the largest problems affecting the promotion of smart economic growth in each country. Despite the fact that the sample groups were not representative (did not reflect the views of the entire population, the obtained survey data and the results of this analysis provided insight into the performance agents’ action ratings from the bottom-up position and allowed comparing the situations in Latvia and Lithuania. The research has become an urgent task in project No. 5.2.3 “Rural and Regional Development Processes and Opportunities in Latvia in the Context of Knowledge Economy” in National Research Programme 5.2. "Economic Transformation, Smart Growth, Governance and Legal Framework for the State and Society for Sustainable Development - a New Approach to the Creation of a Sustainable Learning Community: EKOSOC-LV”.

  3. Early developed section of the jaw as an index of prenatal growth conditions in adult roe deer Capreolus capreolus

    DEFF Research Database (Denmark)

    Høye, Toke Thomas; Forchhammer, Mads Cedergreen

    2006-01-01

    -maturing bones are poor predictors of resource limitations during early development, as later benign conditions may lead to compensatory growth. We analysed the temporal growth dynamics of different sections of the lower jaw of roe deer Capreolus capreolus and found that the medioanterior section of the lower......Increasing evidence suggests that conditions in early life have important consequences for ultimate body size and fitness. Skeletal parts are often used as retrospective indices of body size and growth constraints because of their resistance to seasonal variation in resource availability. Yet, slow...... post partum and, as such, potentially leaves a fingerprint of prenatal growth conditions that is evident even in adult individuals. This supports earlier findings in ungulates of a shift in skeletal growth spurts after weaning, and suggests that the choice of skeletal index for population and cohort...

  4. Irreversibility of a bad start: early exposure to osmotic stress limits growth and adaptive developmental plasticity.

    Science.gov (United States)

    Wu, Chi-Shiun; Gomez-Mestre, Ivan; Kam, Yeong-Choy

    2012-05-01

    Harsh environments experienced early in development have immediate effects and potentially long-lasting consequences throughout ontogeny. We examined how salinity fluctuations affected survival, growth and development of Fejervarya limnocharis tadpoles. Specifically, we tested whether initial salinity effects on growth and rates of development were reversible and whether they affected the tadpoles' ability to adaptively accelerate development in response to deteriorating conditions later in development. Tadpoles were initially assigned to either low or high salinity, and then some were switched between salinity levels upon reaching either Gosner stage 30 (early switch) or 38 (late switch). All tadpoles initially experiencing low salinity survived whereas those initially experiencing high salinity had poor survival, even if switched to low salinity. Growth and developmental rates of tadpoles initially assigned to high salinity did not increase after osmotic stress release. Initial low salinity conditions allowed tadpoles to attain a fast pace of development even if exposed to high salinity afterwards. Tadpoles experiencing high salinity only late in development metamorphosed faster and at a smaller size, indicating an adaptive acceleration of development to avoid osmotic stress. Nonetheless, early exposure to high salinity precluded adaptive acceleration of development, always causing delayed metamorphosis relative to those in initially low salinity. Our results thus show that stressful environments experienced early in development can critically impact life history traits, having long-lasting or irreversible effects, and restricting their ability to produce adaptive plastic responses.

  5. Temperature effects on early season cotton growth and development

    International Nuclear Information System (INIS)

    Reddy, K.R.; Hodges, H.F.; Reddy, V.R.

    1992-01-01

    Temperature is a primary environmental factor controlling growth and developmental rates of plants, yet little specific information is available regarding cotton (Gossypium hisutum L.) responses to temperature. Information covering a wide range of temperatures would be useful for predicting both developmental and growth rates in cotton. Therefore, an experiment was conducted in naturally lit, temperature- and CO 2 -controlled cabinets from soon after emergence until 56 d after emergence (DAE). The cabinets were maintained at 20/12, 25/17, 30/22, 35/27, and 40/32C day/night cycles. Plant heights, number of nodes, and leaf areas were determined weekly throughout the experiment, and dry weight measurements were obtained at three intervals. Mainstem elongation, leaf area growth, and biomass accumulation rates were very sensitive to temperature about 3 wk after emergence. Prior to that time, they were relatively insensitive to temperature. The temperature optimum for stem elongation, leaf area expansion, and biomass accumulation was 30/22 C. Developmental rates, as depicted by number of mainstem nodes produced, number of fruiting branches, and fruiting branch nodes, were not as sensitive to temperatures above 30/22 C as were growth rates. Four times as many fruiting branches were produced at 30/22 C as at 20/12 C; whereas more vegetative branches were produced at low temperatures. All flower buds abscised from plants grown at 40/32 C. Essentially, all bolls and squares were retained at 30/22 C while a 10% boll and square loss was observed at 35/27 C during the early reproductive period. Less time was required for this cultivar to produce squares at any temperature, suitable for growing cotton, than was suggested by previous experiments

  6. Statistical fluctuation phenomenon of early growth fission chain

    International Nuclear Information System (INIS)

    Zheng Chun; Song Lingli

    2008-01-01

    The early growth of neutron population within a supercritical system of fissile material is of a statistical nature and may depart significantly from the average time dependence neutron population. The probability of a source neutron sponsoring a persistent fission chain was considered for a supercritical system. Then the probability distribution in time of the neutron population reaching a preset level was deduced based on the probability P(n,t) of n neutron at time t. By combing the above two probabilities, the probability that at time t after the system reached critical there were no neutron in the system was derived. The P(t) of Godiva neutron excursion at supercritical, and the pre-burst probability of BARS were calculated by this model, and were found agree with the experiment result. (authors)

  7. GROWTH PERFORMANCE OF BROILER CHICKS FED DIETS ...

    African Journals Online (AJOL)

    Dr. A.O. Ani

    2012-06-15

    Jun 15, 2012 ... ISSN 1684–5315 ©2012 Academic Journals ... Increasing raw bambara nut waste levels also depressed (P < 0.05) nutrient absorption ... Key words: Raw bambara nut waste, enzyme, diets, broiler chicks, growth performance.

  8. Impact of childhood asthma on growth trajectories in early adolescence: Findings from the Childhood Asthma Prevention Study (CAPS).

    Science.gov (United States)

    Movin, Maria; Garden, Frances L; Protudjer, Jennifer L P; Ullemar, Vilhelmina; Svensdotter, Frida; Andersson, David; Kruse, Andreas; Cowell, Chris T; Toelle, Brett G; Marks, Guy B; Almqvist, Catarina

    2017-04-01

    Understanding the associations between childhood asthma and growth in early adolescence by accounting for the heterogeneity of growth during puberty has been largely unexplored. The objective was to identify sex-specific classes of growth trajectories during early adolescence, using a method which takes the heterogeneity of growth into account and to evaluate the association between childhood asthma and different classes of growth trajectories in adolescence. Our longitudinal study included participants with a family history of asthma born during 1997-1999 in Sydney, Australia. Hence, all participants were at high risk for asthma. Asthma status was ascertained at 8 years of age using data from questionnaires and lung function tests. Growth trajectories between 11 and 14 years of age were classified using a latent basis growth mixture model. Multinomial regression analyses were used to evaluate the association between asthma and the categorized classes of growth trajectories. In total, 316 participants (51.6% boys), representing 51.3% of the entire cohort, were included. Sex-specific classes of growth trajectories were defined. Among boys, asthma was not associated with the classes of growth trajectories. Girls with asthma were more likely than girls without asthma to belong to a class with later growth (OR: 3.79, 95% CI: 1.33, 10.84). Excluding participants using inhaled corticosteroids or adjusting for confounders did not significantly change the results for either sex. We identified sex-specific heterogeneous classes of growth using growth mixture modelling. Associations between childhood asthma and different classes of growth trajectories were found for girls only. © 2016 Asian Pacific Society of Respirology.

  9. Parental care mitigates carry-over effects of poor early conditions on offspring growth

    Science.gov (United States)

    Auer, Sonya K.; Martin, Thomas E.

    2017-01-01

    Poor developmental conditions can have long-lasting negative effects on offspring phenotypes, but impacts often differ among species. Contrasting responses may reflect disparities in experimental protocols among single-species studies or inherent differences among species in their sensitivity to early conditions and/or ability to mitigate negative impacts. We used a common experimental protocol to assess and compare the role of parental care in mitigating effects of poor early conditions on offspring among 4 sympatric bird species in the wild. We experimentally induced low incubation temperatures and examined effects on embryonic developmental rates, hatching success, nestling growth rates, and parental responses. We examined the generality of these effects across 4 species that differ in their phylogenetic history, breeding ecology, and life histories. We found that cooling led to delayed hatching in all species, but carry-over effects on offspring differed among species. Parents of some but not all species increased their offspring provisioning rates in response to experimental cooling with critical benefits for offspring growth rates. Our study shows for the first time that species exhibit clear differences in the degree to which they are affected by poor early conditions. Observed differences among species demonstrate that parental care is a critical mechanism for mitigating potential negative effects on offspring and suggest that parental responses may be constrained to varying degrees by ecology and life histories.

  10. Comparison of two models of intrauterine growth restriction for early catch-up growth and later development of glucose intolerance and obesity in rats.

    Science.gov (United States)

    Shahkhalili, Yasaman; Moulin, Julie; Zbinden, Irene; Aprikian, Olivier; Macé, Katherine

    2010-01-01

    Two models of intrauterine growth restriction, maternal food restriction (FR), and dexamethasone (DEX) exposure were compared for early postnatal catch-up growth and later development of glucose intolerance and obesity in Sprague-Dawley rats. Mated dams were randomly divided into three groups at 10 days gestational age. Group FR was food restricted (50% of nongestating rats) during the last 11 days of gestation; Group DEX received DEX injections during the last week of gestation, and Group CON, the control group, had no intervention. Birth weight, catch-up growth, body weight, and food intake were measured in male offspring for 22 wk. Body composition, blood glucose, and plasma insulin in response to a glucose load were assessed at 8, 16, and 22 wk. Pups from both FR and DEX dams had similarly lower birth weights than CON (22% and 25%, P growth, which occurred during the suckling period, was much more rapid in FR than DEX offspring (6 vs. 25 days, 95% CI). Postweaning, there were no significant differences between groups in food intake, body weight, body fat, and plasma insulin, but baseline plasma glucose at 22 wk and 2-h glucose area-under-the-curve at 8 and 22 wk were greater only in FR vs. CON offspring (P restriction is a more sensitive model than DEX exposure for studies aimed at investigating the link between low birth weight, early postnatal catch-up growth, and later development of glucose intolerance.

  11. Growth and Biochemical performance of Cassava-Manihot ...

    African Journals Online (AJOL)

    MICHAEL HORSFALL

    the crude oil polluted soil improved the growth and biochemical performance of cassava. For the qualitative .... delay in the rate of soil recovery and a decrease in crop yield ... enhances biodegradation of polluted soil presumably by removing ...

  12. Vigorous root growth is a better indicator of early nutrient uptake than root hair traits in spring wheat grown under low fertility

    DEFF Research Database (Denmark)

    Wang, Yaosheng; Thorup-Kristensen, Kristian; Jensen, Lars Stoumann

    2016-01-01

    . Vigorous root growth, however, was a better indicator of early nutrient acquisition than RHL and RHD. Vigorous root growth and long and dense root hairs ensured efficient acquisition of macro- and micronutrients during early growth and a high root length to shoot dry matter ratio favored high macronutrient......A number of root and root hair traits have been proposed as important for nutrient acquisition. However, there is still a need for knowledge on which traits are most important in determining macro- and micronutrient uptake at low soil fertility. This study investigated the variations in root growth...... vigor and root hair length (RHL) and density (RHD) among spring wheat genotypes and their relationship to nutrient concentrations and uptake during early growth. Six spring wheat genotypes were grown in a soil with low nutrient availability. The root and root hair traits as well as the concentration...

  13. The Early Growth and Development Study: a prospective adoption study from birth through middle childhood.

    Science.gov (United States)

    Leve, Leslie D; Neiderhiser, Jenae M; Shaw, Daniel S; Ganiban, Jody; Natsuaki, Misaki N; Reiss, David

    2013-02-01

    The Early Growth and Development Study is a prospective adoption study of birth parents, adoptive parents, and adopted children recruited in two cohorts (N = 561 triads). The primary study aims are to examine how family, peer, and contextual processes affect children's adjustment, and to examine their interplay (mediation, moderation) with genetic influences. Participants were recruited through adoption agencies located throughout the United States following the birth of a child. Assessments are ongoing, in 9-month intervals until the child reaches 3 years of age and in 1-year intervals thereafter through age 9. Data collection includes the following primary constructs: child temperament, social behavior, school performance, mental health, and health; birth and adoptive parent personality characteristics, mental health, competence, stress, health, context, substance use, parenting, and marital relations; and pregnancy use of drugs and maternal stress during pregnancy. DNA and salivary cortisol samples have also been collected. Analyses have indicated evidence for genotype-environment interactions during early childhood. Study procedures, sample representativeness (including tests of potential confounds in the adoption design), and an overview of findings to date are summarized, and future plans are described.

  14. Early kit mortality and growth in farmed mink are affected by litter size rather than nest climate.

    Science.gov (United States)

    Schou, T M; Malmkvist, J

    2017-09-01

    We investigated the effects of nest box climate on early mink kit mortality and growth. We hypothesised that litters in warm nest boxes experience less hypothermia-induced mortality and higher growth rates during the 1st week of life. This study included data from 749, 1-year-old breeding dams with access to nesting materials. Kits were weighed on days 1 and 7, dead kits were collected daily from birth until day 7 after birth, and nest climate was measured continuously from days 1 to 6. We tested the influences of the following daily temperature (T) and humidity (H) parameters on the number of live-born kit deaths and kit growth: T mean, T min, T max, T var (fluctuation) and H mean. The nest microclimate experienced by the kits was buffered against the ambient climate, with higher temperatures and reduced climate fluctuation. Most (77.0%) live-born kit deaths in the 1st week occurred on days 0 and 1. Seven of 15 climate parameters on days 1 to 3 had significant effects on live-born kit mortality. However, conflicting effects among days, marginal effects and late effects indicated that climate was not the primary cause of kit mortality. Five of 30 climate parameters had significant effects on kit growth. Few and conflicting effects indicated that the climate effect on growth was negligible. One exception was that large nest temperature fluctuations on day 1 were associated with reduced deaths of live-born kit (P<0.001) and increased kit growth (P=0.003). Litter size affected kit vitality; larger total litter size at birth was associated with greater risks of kit death (P<0.001) and reduced growth (P<0.001). The number of living kits in litters had the opposite effect, as kits in large liveborn litters had a reduced risk of death (P<0.001) and those with large mean litter size on days 1 to 7 had increased growth (P=0.026). Nest box temperature had little effect on early kit survival and growth, which could be due to dams' additional maternal behaviour. Therefore, we

  15. Toward an adverse outcome pathway for impaired growth: Mitochondrial dysfunction impairs growth in early life stages of the fathead minnow (Pimephales promelas).

    Science.gov (United States)

    Bolser, Derek G; Dreier, David A; Li, Erchao; Kroll, Kevin J; Martyniuk, Christopher J; Denslow, Nancy D

    2018-07-01

    Chemical contaminants present in the environment can affect mitochondrial bioenergetics in aquatic organisms and can have substantial effects on individual fitness. As early life stages of fish are particularly vulnerable to environmental contaminants, they are ideal models for examining the relationship between impaired mitochondrial bioenergetics (ATP-dependent respiration, basal oxidative respiration) and apical endpoints such as growth. Here, early life stages of the fathead minnow (Pimephales promelas), an ecologically relevant North American species, were used to investigate the relationship between mitochondrial bioenergetics and growth following perturbation with model mitochondrial toxicants 2,4-dinitrophenol and octylamine. Fathead minnows were exposed to 2,4-dinitrophenol and octylamine at 3 concentrations for 24 h and endpoints related to mitochondrial bioenergetics were measured with the Agilent Seahorse XFe24 Bioanalyzer. In order to link changes in mitochondrial bioenergetics to growth, fathead minnows were exposed to the same chemical contaminants for 7-14 days and growth was measured by measuring total length on a weekly basis. There was a significant correlation between decrease in average length at 14 days and basal respiration (r = 0.997, p = 0.050, n = 3), as well as maximal respiration (r = 0.998, p-value = 0.043, n = 3) for embryos exposed to 2,4 dinitrophenol. For octylamine, ATP production was highly correlated with average length at 7 days (p-value = 0.1) and spare respiratory capacity and average length at 14 days were highly correlated (p-value = 0.1). These data improve understanding of how mitochondrial toxicants impair growth in fish larvae and may be useful for developing an adverse outcome pathway for growth. Copyright © 2018 Elsevier Inc. All rights reserved.

  16. Impact of growth patterns and early diet on obesity and cardiovascular risk factors in young children from developing countries.

    Science.gov (United States)

    Corvalán, Camila; Kain, Juliana; Weisstaub, Gerardo; Uauy, Ricardo

    2009-08-01

    Non-communicable chronic diseases are now a worldwide epidemic. Diet and physical activity throughout life are among its main determinants. In countries undergoing the early stages of the nutrition transition weight gain from birth to 2 years of life is related to lean mass gain, while ponderal gain after age 2 years is related to adiposity and later diabetes and CVD risk. Evidence from developing countries undergoing the more advanced stages of the nutrition transition is limited. The early growth patterns of a cohort of Chilean children born in 2002 with normal birth weight who at 4 years had a high prevalence of obesity and CVD risk factors have been assessed. Results indicate that BMI gain in early life, particularly from 6 months to 24 months, is positively associated with adiposity and CVD risk status at 4 years. These results together with existing evidence suggest that actions to prevent obesity and nutrition-related chronic diseases in developing countries should start early in life, possibly after 6 months of age. This approach should consider assessing the effect of mode of feeding and the amount and type of energy fed, as well as the resulting growth patterns. The challenge for researchers addressing the nutrition transition is to define the optimal nutrition in early life, considering not only the short- and long-term health consequences but also taking into account the stage of the nutritional transition for the given population of interest. The latter will probably require redefining optimal postnatal growth based on the context of maternal size and fetal growth.

  17. Activity of toluene-degrading Pseudomonas putida in the early growth phase of a biofilm for waste gas treatment

    DEFF Research Database (Denmark)

    Pedersen, A.R.; Møller, S.; Molin, S.

    1997-01-01

    A biological trickling filter for treatment of toluene-containing waste gas was studied. The overall kinetics of the biofilm growth was followed in the early growth phase. A rapid initial colonization took place during the first three days. The biofilm thickness increased exponentially, whereas...

  18. Disturbances of bone growth and development

    International Nuclear Information System (INIS)

    Ledesma-Medina, J.; Newman, B.; Oh, K.S.

    1988-01-01

    ''What is growth anyway? Can one talk about positive growth in childhood, neutral growth in maturity, and negative growth in old age? Our goal is to help promote normal positive growth in infants and children. To achieve this, we must be cognizant of the morphologic changes of both normal and abnormal bone formation as they are reflected in the radiographic image of the skeleton. The knowledge of the various causes and the pathophysiologic mechanisms of the disturbances of bone growth and development allows us to recognize the early radiographic manifestations. Endocrine and metabolic disorders affect the whole skeleton, but the early changes are best seen in the distal ends of the femurs, where growth rate is most rapid. In skeletal infections and in some vascular injuries two-or three-phase bone scintigraphy supercedes radiography early in the course of the disease. MRI has proved to be very helpful in the early detection of avascular bone necrosis, osteomyelitis, and tumor. Some benign bone tumors and many bone dysplasias have distinct and diagnostic radiographic findings that may preclude further studies. In constitutional diseases of bone, including chromosomal aberrations, skeletal surveys of the patient and all family members together with biochemical and cytogenetic studies are essential for both diagnosis and genetic counseling. Our role is to perform the least invasive and most informative diagnostic imaging modalities that corroborate the biochemical and histologic findings to establish the definitive diagnosis. Unrecognized, misdiagnosed, or improperly treated disturbance of bone growth can result in permanent deformity usually associated with disability. 116 references

  19. Growth Performance and Hematological Traits of Weaner Pigs Fed ...

    African Journals Online (AJOL)

    BSN

    http://www.ajol.info/index.php/njb/index and ... for their growth and haematological parameters when fed graded levels of raw ... significant (P<0.05) differences among treatments in feed intake, weight gain, ... Keywords: Growth Performance, Bambara nut wastes, Weaner Pigs and ... waste used in the feeding of pigs (Okeke,.

  20. Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae

    DEFF Research Database (Denmark)

    Yagüe, Paula; Willemse, Joost; Koning, Roman I

    2016-01-01

    Bacteria of the genus Streptomyces are a model system for bacterial multicellularity. Their mycelial life style involves the formation of long multinucleated hyphae during vegetative growth, with occasional cross-walls separating long compartments. Reproduction occurs by specialized aerial hyphae......, which differentiate into chains of uninucleoid spores. While the tubulin-like FtsZ protein is required for the formation of all peptidoglycan-based septa in Streptomyces, canonical divisome-dependent cell division only occurs during sporulation. Here we report extensive subcompartmentalization in young...... vegetative hyphae of Streptomyces coelicolor, whereby 1 μm compartments are formed by nucleic acid stain-impermeable barriers. These barriers possess the permeability properties of membranes and at least some of them are cross-membranes without detectable peptidoglycan. Z-ladders form during the early growth...

  1. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction)

    DEFF Research Database (Denmark)

    Pels, A; Kenny, L C; Alfirevic, Z

    2017-01-01

    randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants......BACKGROUND: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate...... Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis. METHODS: Five national/bi-national multicentre...

  2. Contrasting shrub species respond to early summer temperatures leading to correspondence of shrub growth patterns

    Science.gov (United States)

    Weijers, Stef; Pape, Roland; Löffler, Jörg; Myers-Smith, Isla H.

    2018-03-01

    The Arctic-alpine biome is warming rapidly, resulting in a gradual replacement of low statured species by taller woody species in many tundra ecosystems. In northwest North America, the remotely sensed normalized difference vegetation index (NDVI), suggests an increase in productivity of the Arctic and alpine tundra and a decrease in productivity of boreal forests. However, the responses of contrasting shrub species growing at the same sites to climate drivers remain largely unexplored. Here, we test growth, climate, and NDVI relationships of two contrasting species: the expanding tall deciduous shrub Salix pulchra and the circumarctic evergreen dwarf shrub Cassiope tetragona from an alpine tundra site in the Pika valley in the Kluane Region, southwest Yukon Territories, Canada. We found that annual growth variability of both species at this site is strongly driven by early summer temperatures, despite their contrasting traits and habitats. Shrub growth chronologies for both species were correlated with the regional climate signal and showed spatial correspondence with interannual variation in NDVI in surrounding alpine and Arctic regions. Our results suggest that early summer warming represents a common driver of vegetation change for contrasting shrub species growing in different habitats in the same alpine environments.

  3. Management of Very Early-onset Fetal Growth Restriction: Results from 92 Consecutive Cases.

    Science.gov (United States)

    Hoellen, Friederike; Beckmann, Annika; Banz-Jansen, Constanze; Weichert, Jan; Rody, Achim; Bohlmann, Michael K

    2016-01-01

    To evaluate management of early-onset intrauterine growth restriction (IUGR) and to define outcome according to obstetric setting. During an 11-year period (2000-2011), data of patients presenting with IUGR and preterm delivery of less than 30 weeks of gestation at a tertiary perinatal center were retrospectively reviewed. A total of 92 pregnancies were investigated. Delivery was indicated for fetal reasons in 38 out of 92 patients. Sixteen children of our cohort died within one year post partum, out of which eight had suffered from severe early-onset IUGR causing iatrogenic preterm delivery. Concerning the fetal outcome, gestational age at delivery and antenatal exposure to corticosteroids were found to be crucial. In some cases, respiratory distress syndrome prophylaxis and a "wait and see" approach to management in favor of a prolongation of the pregnancy might be favorable. Randomized prospective trials in early-onset IUGR with threatened preterm deliveries are needed in order to define guidelines for an individually tailored management of early-onset preterm infants. Copyright © 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  4. Massage therapy during early postnatal life promotes greater lean mass and bone growth, mineralization, and strength in juvenile and young adult rats.

    Science.gov (United States)

    Chen, H; Miller, S; Shaw, J; Moyer-Mileur, L

    2009-01-01

    The objects of this study were to investigate the effects of massage therapy during early life on postnatal growth, body composition, and skeletal development in juvenile and young adult rats. Massage therapy was performed for 10 minutes daily from D6 to D10 of postnatal life in rat pups (MT, n=24). Body composition, bone area, mineral content, and bone mineral density were measured by dual energy X-ray absorptiometry (DXA); bone strength and intrinsic stiffness on femur shaft were tested by three-point bending; cortical and cancellous bone histomorphometric measurements were performed at D21 and D60. Results were compared to age- and gender-matched controls (C, n=24). D21 body weight, body length, lean mass, and bone area were significantly greater in the MT cohort. Greater bone mineral content was found in male MT rats; bone strength and intrinsic stiffness were greater in D60 MT groups. At D60 MT treatment promoted bone mineralization by increasing trabecular mineral apposition rate in male and endosteal mineral surface in females, and also improved micro-architecture by greater trabeculae width in males and decreasing trabecular separation in females. In summary, massage therapy during early life elicited immediate and prolonged anabolic effects on postnatal growth, lean mass and skeletal developmental in a gender-specific manner in juvenile and young adult rats.

  5. Has growth mixture modeling improved our understanding of how early change predicts psychotherapy outcome?

    Science.gov (United States)

    Koffmann, Andrew

    2017-03-02

    Early change in psychotherapy predicts outcome. Seven studies have used growth mixture modeling [GMM; Muthén, B. (2001). Second-generation structural equation modeling with a combination of categorical and continuous latent variables: New opportunities for latent class-latent growth modeling. In L. M. Collins & A. G. Sawyers (Eds.), New methods for the analysis of change (pp. 291-322). Washington, DC: American Psychological Association] to identify patient classes based on early change but have yielded conflicting results. Here, we review the earlier studies and apply GMM to a new data set. In a university-based training clinic, 251 patients were administered the Outcome Questionnaire-45 [Lambert, M. J., Hansen, N. B., Umphress, V., Lunnen, K., Okiishi, J., Burlingame, G., … Reisinger, C. W. (1996). Administration and scoring manual for the Outcome Questionnaire (OQ 45.2). Wilmington, DE: American Professional Credentialing Services] at each psychotherapy session. We used GMM to identify class structure based on change in the first six sessions and examined trajectories as predictors of outcome. The sample was best described as a single class. There was no evidence of autoregressive trends in the data. We achieved better fit to the data by permitting latent variables some degree of kurtosis, rather than to assume multivariate normality. Treatment outcome was predicted by the amount of early improvement, regardless of initial level of distress. The presence of sudden early gains or losses did not further improve outcome prediction. Early improvement is an easily computed, powerful predictor of psychotherapy outcome. The use of GMM to investigate the relationship between change and outcome is technically complex and computationally intensive. To date, it has not been particularly informative.

  6. Impact of Early Versus Late Diuretic Exposure on Metabolic Bone Disease and Growth in Premature Neonates.

    Science.gov (United States)

    Orth, Lucas E; O'Mara, Keliana L

    2018-01-01

    This study aimed to determine whether there are differences in the incidence of metabolic bone disease (MBD) between preterm neonates first exposed to diuretics prior to 2 weeks of life versus those exposed after 2 weeks. This study was a retrospective analysis of premature neonates born at a tertiary care center between 2011 and 2015 who received either furosemide or chlorothiazide. The primary outcome was incidence of MBD. Secondary outcomes included growth, electrolyte disturbances, oxygen requirement, and length of stay. A total of 147 patients were included. Early initiation (n = 90) and late initiation (n = 57) arms were balanced with respect to birth weight and gestational age. There was no difference in incidence of MBD in the early group (76%) versus the late group (65%; p = 0.164). Stratification by cumulative dose showed incidence of 85% in patients receiving ≥8 mg/kg of furosemide, compared with 68% and 64% of those in the <4 mg/kg and 4 to 7.9 mg/kg strata, respectively (p = 0.06). The early group experienced greater reductions in length-for-age growth during diuretic therapy (-70% versus -40%; p = 0.009). Electrolyte abnormalities were more prevalent in the early group. Although there was no difference in duration of mechanical ventilation, duration of supplemental oxygen requirement was reduced in the late group (75 versus 89 days; p = 0.003). Timing of diuretic initiation did not affect incidence of MBD. Increased cumulative furosemide exposure may be associated with higher incidence. Patients first exposed to diuretics within 2 weeks of life are at higher risk for electrolyte abnormalities and reduced growth velocity.

  7. Morphological development and allometric growth patterns of Acipenser persicus Borodin, 1897 (Actinopterygii, Acipenseridae during early development

    Directory of Open Access Journals (Sweden)

    Soheil Eagderi

    2017-06-01

    Full Text Available Morphological development and allometric growth patterns of reared Persian sturgeon, Acipenser persicus, were studied from hatching to 50 days post-hatching (dph. The larvae were sampled, their left sides photographed and seven morphometric characters, including total length, head length, tail length, trunk length, snout length, caudal peduncle and predorsal length were measured. Allometric growth patterns were calculated as a power function of total length and described using the growth coefficient to find important steps in early life history. The total length of the newly hatched larvae and fry were 10.59±0.8 and 38.8±2.9 mm at 1 and 50 dph, respectively. Morphogenesis and differentiation were the highest rates during the first 11 days of early development, i.e. endogenous feeding period. There were higher growth rate of head, snout and tail regions compared with those of other organs from the hatch up to yolk sac absorption, followed by positive or almost isometric patterns, after the begin of exogenous feeding, showing priority to enhance the feeding and swimming capabilities. This study confirmed that most of morphological changes of this species are occurred from hatching until the onset of exogenous feeding i.e. during the lecithotrophic phase.

  8. Early Numerical Competence and Number Line Task Performance in Kindergarteners

    Science.gov (United States)

    Fanari, Rachele; Meloni, Carla; Massidda, Davide

    2017-01-01

    This work aims to evaluate the relationship between early numerical competence in kindergarteners and their numerical representations as measured by the number line task (NLT). Thirty-four 5-year-old children participated in the study. Children's early performance on symbolic and non-symbolic numerical tasks was considered to determine which was a…

  9. An early feeding regime and a high-density amino acid diet on growth performance of broilers under subclinical necrotic enteritis challenge

    Directory of Open Access Journals (Sweden)

    Chake Keerqin

    2017-03-01

    Full Text Available Broilers that have early access to feed have been shown to have enhanced immune system and gut development and heightened resilience against necrotic enteritis (NE. This study examined the effect of early feeding a high amino acid density diet on performance of broilers under a sub-clinical NE challenge model. Ross 308 broilers (n = 576 were assigned to a 2 × 2 × 2 factorial design with 2 feeding regimes (feed access either within 6 h post-hatch or after 48 h post-hatch, 2 diets (control diet or the control diet with an additional 10% digestible amino acids [HAA] and either presence or absence of NE challenge. Oral administrations of Eimeria species (d 9 and a field strain of Clostridium perfringens (d 14 were used to induce NE. Broiler performance was analysed at d 13, 23, 30 and 35. Intestinal lesion score and bacterial count were analysed on d 16. The NE challenge reduced overall bird performance and induced severe intestinal lesions, without causing notable mortality. At d 23 bird weight was significantly lower (P < 0.001 in the challenged birds compared with the unchallenged birds, but by d 30 the challenged birds had recovered and challenge no longer had an impact on bird performance. Birds fed the HAA diet had greater body weight by d 35 and heightened Lactobacillus content in the ileum at d 16 (P < 0.05. Birds that were fed the HAA diet after a period of fasting performed better in terms of feed conversion ratio (FCR under challenge. The findings from this study suggest there are beneficial effects of feeding high amino acid diets to birds in response to external stresses, such as post-hatch fasting and subclinical NE.

  10. Impact of Pretreatment Tumor Growth Rate on Outcome of Early-Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Atallah, Soha; Cho, B.C. John; Allibhai, Zishan; Taremi, Mojgan; Giuliani, Meredith [Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Le, Lisa W. [Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Brade, Anthony; Sun, Alexander; Bezjak, Andrea [Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada); Hope, Andrew J., E-mail: andrew.hope@rmp.uhn.on.ca [Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario (Canada); Department of Radiation Oncology, University of Toronto, Toronto, Ontario (Canada)

    2014-07-01

    Purpose: To determine the influence of pretreatment tumor growth rate on outcomes in patients with early-stage non-small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). Methods and Materials: A review was conducted on 160 patients with T1-T2N0M0 NSCLC treated with SBRT at single institution. The patient's demographic and clinical data, time interval (t) between diagnostic and planning computed tomography (CT), vital status, disease status, and cause of death were extracted from a prospectively kept database. Differences in gross tumor volume between diagnostic CT (GTV1) and planning CT (GTV2) were recorded, and growth rate was calculated by use of specific growth rate (SGR). Kaplan-Meier curves were constructed for overall survival (OS). Differences between groups were compared with a log-rank test. Multivariate analyses were performed by use of the Cox proportional hazard model with SGR and other relevant clinical factors. Cumulative incidence was calculated for local, regional, and distant failures by use of the competing risk approach and was compared with Gray's test. Results: The median time interval between diagnostic and planning CT was 82 days. The patients were divided into 2 groups, and the median SGR was used as a cut-off. The median survival times were 38.6 and 27.7 months for the low and high SGR groups, respectively (P=.03). Eastern Cooperative Oncology Group performance status (P=.01), sex (P=.04), SGR (P=.03), and GTV2 (P=.002) were predictive for OS in multivariable Cox regression analysis and, except sex, were similarly predictive for failure-free survival (FFS). The 3-year cumulative incidences of regional failure were 19.2% and 6.0% for the high and low SGR groups, respectively (P=.047). Conclusion: High SGR was correlated with both poorer OS and FFS in patients with early-stage NSCLC treated with SBRT. If validated, this measurement may be useful in identifying patients most likely to benefit from

  11. Growth performance and immunological responses of broiler ...

    African Journals Online (AJOL)

    This study was conducted to determine the growth performance and immune response of broiler chickens fed synbiotic and diet acidifier to Newcastle disease vaccinations. One hundred and forty four (144) day old broiler chickens were randomly assigned to four dietary treatments replicated thrice with 12 birds per replicate ...

  12. Growth performance, blood parameters and carcass characteristics ...

    African Journals Online (AJOL)

    This study was carried out with one hundred and twenty (120) day-old marshal chicks to investigate the effect of Maxigrain® enzyme supplementation of corn bran based diets on growth performance, carcass characteristics, haematology and serum biochemistry of broilers in an eight weeks experiment. Four experimental ...

  13. Correlations between the anatomical traits of Gymnocladus canadensis Lam. in heartwood and sapwood of early- and latewood zones of growth rings

    Directory of Open Access Journals (Sweden)

    Jokanović Dušan

    2015-01-01

    Full Text Available This paper shows correlations between vessel characteristics and differences in growth-ring width in heartwood and sapwood. Analyzed samples were from an iron-wood tree (Gymnocladus canadensis Lam. that grew in the Mužljanski Rit area, of the Srpska Crnja municipality in Serbia. According to previous research, it was deduced that Gymnocladus canadensis Lam. belongs to ring-porous species with big vessel lumen in the earlywood zone and thicker cell walls in the latewood. Vessels were more numerous in the latewood zone, and the same was true for heartwood and sapwood. For both layers, sapwood possessed a few more vessels than heartwood, and a statistically significant difference was confirmed by t-test during the early phase. The greatest negative value of correlation coefficient was between the number of vessels and growth-ring width during the early phase for sapwood. The number of vessels decreased in the wider growth rings. The correlation between growth-ring width and the area of vessels had a statistically significant positive value of correlative coefficient, which means that wider growth rings had larger vessel areas in the early phase for sapwood. [Projekat Ministarstva nauke Republike Srbije, br. 31041

  14. Ultrasonographic findings of early abortion: suggested predictors

    International Nuclear Information System (INIS)

    Jun, Soon Ae; Ahn, Myoung Ock; Cha, Kwang Yul; Lee, Young Doo

    1992-01-01

    To investigate predictable ultrasonographic findings of early abortion. To investigate objective rules for the screening of abortion. Ultrasonographic examination of 111 early pregnancies between the sixth and ninth week in women who had regular 28 day menstrual cycles was performed. Ultrasonographic measurements of the gestational sac, crown rump length and fetal heart rate were performed using a linear array real time transducer with doppler ultrasonogram. All measurements of 17 early abortions were compared to those of 94 normal pregnancies. Most of early aborted pregnancies were classified correctly by discriminant analysis with G-SAC and CRL (G-SAC=0.5 CRL + 15, sensitivity 76.5%, specificity 96.8%). With the addition of FHR, 94.1% of early abortions could be predicted. In conclusion, ultrasonographic findings of early intrauterine growth retardation, small gestational sac and bradycardia can be predictable signs suggestive of poor prognosis of early pregnancies

  15. Transformation by Oncogenic Ras Expands the Early Genomic Response to Transforming Growth Factor β in Intestinal Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Carl E. Allen

    2008-10-01

    Full Text Available A substantial body of evidence implicates TGFβ as a tumor promoter in epithelial cells that have become resistant to its tumor suppressor activity. To better understand early, genome-wide TGFβ responses in cells resistant to growth inhibition by TGFβ, we used microarray analysis in a well-defined cell culture system of sensitive and resistant intestinal epithelial cells. TGFβ-regulated gene expression in TGFβ-growth-sensitive, nontransformed rat intestinal epithelial cells (RIE-1 was compared to expression in TGFβ-growth-resistant RIE cells stably transformed by oncogenic Ras(12V. Treatment of RIE-1 cells with 2 ng/ml TGFβ1 for 1 hour increased the expression of eight gene sequences by 2.6-fold or more, whereas eight were down regulated 2.6-fold. In RIE-Ras(12V cells, 42 gene sequences were upregulated and only 3 were down-regulated. Comparison of RIE and RIE-Ras(12V identified 37 gene sequences as unique, Ras-dependent genomic targets of TGFβ1. TGFβ-regulation of connective tissue growth factor and vascular endothelial growth factor, two genes up-regulated in RIE-Ras cells and previously implicated in tumor promotion, was independently confirmed and further characterized by Northern analysis. Our data indicate that overexpression of oncogenic Ras in intestinal epithelial cells confers a significantly expanded repertoire of robust, early transcriptional responses to TGFβ via signaling pathways yet to be fully elucidated but including the canonical Raf-1/MAPK/Erk pathway. Loss of sensitivity to growth inhibition by TGFβ does not abrogate TGFβ signaling and actually expands the early transcriptional response to TGFβ1. Expression of some of these genes may confer to Ras-transformed cells characteristics favorable for tumor promotion.

  16. Developmental programming of somatic growth, behavior and endocannabinoid metabolism by variation of early postnatal nutrition in a cross-fostering mouse model.

    Science.gov (United States)

    Schreiner, Felix; Ackermann, Merle; Michalik, Michael; Hucklenbruch-Rother, Eva; Bilkei-Gorzo, Andras; Racz, Ildiko; Bindila, Laura; Lutz, Beat; Dötsch, Jörg; Zimmer, Andreas; Woelfle, Joachim

    2017-01-01

    Nutrient deprivation during early development has been associated with the predisposition to metabolic disorders in adulthood. Considering its interaction with metabolism, appetite and behavior, the endocannabinoid (eCB) system represents a promising target of developmental programming. By cross-fostering and variation of litter size, early postnatal nutrition of CB6F1-hybrid mice was controlled during the lactation period (3, 6, or 10 pups/mother). After weaning and redistribution at P21, all pups received standard chow ad libitum. Gene expression analyses (liver, visceral fat, hypothalamus) were performed at P50, eCB concentrations were determined in liver and visceral fat. Locomotor activity and social behavior were analyzed by means of computer-assisted videotracking. Body growth was permanently altered, with differences for length, weight, body mass index and fat mass persisting beyond P100 (all 3>6>10,p6>10 (DAGLα p6>10 (FAAH pOpen-field social behavior testing revealed significant group differences, with formerly underfed mice turning out to be the most sociable animals (p<0.01). Locomotor activity did not differ. Our data indicate a developmental plasticity of somatic growth, behavior and parameters of the eCB system, with long-lasting impact of early postnatal nutrition. Developmental programming of the eCB system in metabolically active tissues, as shown here for liver and fat, may play a role in the formation of the adult cardiometabolic risk profile following perinatal malnutrition in humans.

  17. The Growth Story: Canada's Long-run Economic Performance and Prospects

    OpenAIRE

    Peter J. Nicholson

    2003-01-01

    In this lead article, Peter Nicholson, who until recently served as advisor to the Secretary General at the OECD and is currently serving as policy advisor to the Prime Minister, Paul Martin, discusses the long-run economic performance, prospects in Canada, and policy priorities based on the framework and insights that emerged from the recent study of economic growth released by the OECD. He argues that Canada has performed remarkably well since the mid-1990s, and that by the pro-growth polic...

  18. Performance IQ in children is associated with blood cadmium concentration in early pregnancy.

    Science.gov (United States)

    Jeong, Kyoung Sook; Park, Hyewon; Ha, Eunhee; Hong, Yun-Chul; Ha, Mina; Park, Hyesook; Kim, Bung-Nyun; Lee, Bo-Eun; Lee, Soo-Jeong; Lee, Kyung Yeon; Kim, Ja Hyeong; Kim, Yangho

    2015-04-01

    To investigate whether performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. The present study is a component of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center birth cohort project in Korea that began in 2006. The study cohort consisted of 119 children whose mothers underwent testing of blood cadmium during early pregnancy. All children were evaluated using the Korean version of the Wechsler Preschool and Primary Scale of Intelligence, revised edition (WPPSI-R), at 60 months of age. Multivariate linear regression analysis was performed to analyze the correlation between IQ in children and maternal blood cadmium concentration in early pregnancy, after adjustment for covariates. Maternal blood cadmium concentration during early pregnancy was inversely associated with performance IQ, after adjustment for covariates such as sex, educational levels of both parents, family income, and maternal BMI. Maternal blood cadmium concentration, however, was not associated with cognitive IQ. Performance IQ in children is associated with maternal blood cadmium concentration in early pregnancy. Copyright © 2014 Elsevier GmbH. All rights reserved.

  19. Early growth and development impairments in patients with ganglioside GM3 synthase deficiency.

    Science.gov (United States)

    Wang, H; Wang, A; Wang, D; Bright, A; Sency, V; Zhou, A; Xin, B

    2016-05-01

    Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GSD) causes a complete absence of GM3 and all downstream biosynthetic derivatives. The individuals affected by this disorder manifest severe irritability, intractable seizures and profound intellectual disability. However, we have found that most newborns seem symptom-free for a period of time after birth. In order to further understand the onset of the disease, we investigated the early growth and development of patients with this condition through this study. We compared 37 affected individuals with their normal siblings and revealed that all children with GSD had relatively normal intrauterine growth and development, as their weight, length and head circumference were similar to their normal siblings at birth. However, the disease progresses quickly after birth and causes significant constitutional impairments of growth and development by 6 months of age. Neither breastfeeding nor gastrostomy tube placement made significant difference on growth and development as all groups of patients showed the similar pattern. We conclude that GSD causes significant postnatal growth and developmental impairments and the amount of gangliosides in breast milk and general nutritional intervention do not seem to alter these outcomes. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Performance Analysis of a Citywide Real-time Landslide Early Warning System in Korea

    Science.gov (United States)

    Park, Joon-Young; Lee, Seung-Rae; Kang, Sinhang; Lee, Deuk-hwan; Nedumpallile Vasu, Nikhil

    2017-04-01

    Rainfall-induced landslide has been one of the major disasters in Korea since the beginning of 21st century when the global climate change started to give rise to the growth of the magnitude and frequency of extreme precipitation events. In order to mitigate the increasing damage to properties and loss of lives and to provide an effective tool for public officials to manage the landslide disasters, a real-time landslide early warning system with an advanced concept has been developed by taking into account for Busan, the second largest metropolitan city in Korea, as an operational test-bed. The system provides with warning information based on a five-level alert scheme (Normal, Attention, Watch, Alert, and Emergency) using the forecasted/observed rainfall data or the data obtained from ground monitoring (volumetric water content and matric suction). The alert levels are determined by applying seven different thresholds in a step-wise manner following a decision tree. In the pursuit of improved reliability of an early warning level assigned to a specific area, the system makes assessments repetitively using the thresholds of different theoretical backgrounds including statistical(empirical), physically-based, and mathematical analyses as well as direct measurement-based approaches. By mapping the distribution of the five early warning levels determined independently for each of tens of millions grids covering the entire mountainous area of Busan, the regional-scale system can also provide with the early warning information for a specific local area. The fact that the highest warning level is determined by using a concept of a numerically-modelled potential debris-flow risk is another distinctive feature of the system. This study tested the system performance by applying it for four previous rainy seasons in order to validate the operational applicability. During the rainy seasons of 2009, 2011, and 2014, the number of landslides recorded throughout Busan's territory

  1. Growth performance and certain body measurements of ostrich ...

    African Journals Online (AJOL)

    Growth performance and certain body measurements of ostrich chicks as affected by dietary protein levels during 2–9 weeks of age. Kh M Mahrose, AI Attia, IE Ismail, DE Abou-Kassem, ME Abd El-Hack ...

  2. Regulation of radiation-induced apoptosis by early growth response-1 gene in solid tumors

    International Nuclear Information System (INIS)

    Ahmed, M.

    2003-01-01

    Ionizing radiation exposure is associated with activation of certain immediate-early genes that function as transcription factors. These include members of jun or fos and early growth response (EGR) gene families. In particular, the functional role of EGR-1 in radiation-induced signaling is pivotal since the promoter of EGR-1 contains radiation-inducible CArG DNA sequences. The Egr-1 gene belongs to a family of Egr genes that includes EGR-2, EGR-3, EGR-4, EGR-α and the tumor suppressor, Wilms' tumor gene product, WT1. The Egr-1 gene product, EGR-1, is a nuclear protein that contains three zinc fingers of the C 2 H 2 subtype. The EGR-1 GC-rich consensus target sequence, 5'-GCGT/GGGGCG-3' or 5'-TCCT/ACCTCCTCC-3', has been identified in the promoter regions of transcription factors, growth factors, receptors, cell cycle regulators and pro-apoptotic genes. The gene targets mediated by Egr-1 in response to ionizing radiation include TNF-α , p53, Rb and Bax, all these are effectors of apoptosis. Based on these targets, Egr-1 is a pivotal gene that initiates early signal transduction events in response to ionizing radiation leading to either growth arrest or cell death in tumor cells. There are two potential application of Egr-1 gene in therapy of cancer. First, the Egr-1 promoter contains information for appropriate spatial and temporal expression in-vivo that can be regulated by ionizing radiation to control transcription of genes that have pro-apoptotic and suicidal function. Secondly, EGR-1 protein can eliminate 'induced-radiation resistance' by inhibiting the functions of radiation-induced pro-survival genes (NFκB activity and bcl-2 expression) and activate pro-apoptotic genes (such as bax) to confer a significant radio-sensitizing effect. Together, the reported findings from my laboratory demonstrate clearly that EGR-1 is an early central gene that confers radiation sensitivity and its pro-apoptotic functions are synergized by abrogation of induced radiation

  3. Kindergarteners' performance in a sound-symbol paradigm predicts early reading.

    Science.gov (United States)

    Horbach, Josefine; Scharke, Wolfgang; Cröll, Jennifer; Heim, Stefan; Günther, Thomas

    2015-11-01

    The current study examined the role of serial processing of newly learned sound-symbol associations in early reading acquisition. A computer-based sound-symbol paradigm (SSP) was administered to 243 children during their last year of kindergarten (T1), and their reading performance was assessed 1 year later in first grade (T2). Results showed that performance on the SSP measured before formal reading instruction was associated with later reading development. At T1, early readers performed significantly better than nonreaders in learning correspondences between sounds and symbols as well as in applying those correspondences in a serial manner. At T2, SSP performance measured at T1 was positively associated with reading performance. Importantly, serial application of newly learned correspondences at T1 explained unique variance in first-grade reading performance in nonreaders over and above other verbal predictors, including phonological awareness, verbal short-term memory, and rapid automatized naming. Consequently, the SSP provides a promising way to study aspects of reading in preliterate children. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Orientation selection process during the early stage of cubic dendrite growth: A phase-field crystal study

    International Nuclear Information System (INIS)

    Tang Sai; Wang Zhijun; Guo Yaolin; Wang Jincheng; Yu Yanmei; Zhou Yaohe

    2012-01-01

    Using the phase-field crystal model, we investigate the orientation selection of the cubic dendrite growth at the atomic scale. Our simulation results reproduce how a face-centered cubic (fcc) octahedral nucleus and a body-centered cubic (bcc) truncated-rhombic dodecahedral nucleus choose the preferred growth direction and then evolve into the dendrite pattern. The interface energy anisotropy inherent in the fcc crystal structure leads to the fastest growth velocity in the 〈1 0 0〉 directions. New { 1 1 1} atomic layers prefer to nucleate at positions near the tips of the fcc octahedron, which leads to the directed growth of the fcc dendrite tips in the 〈1 0 0〉 directions. A similar orientation selection process is also found during the early stage of bcc dendrite growth. The orientation selection regime obtained by phase-field crystal simulation is helpful for understanding the orientation selection processes of real dendrite growth.

  5. Ezh2 Controls an Early Hematopoietic Program and Growth and Survival Signaling in Early T Cell Precursor Acute Lymphoblastic Leukemia

    Directory of Open Access Journals (Sweden)

    Etienne Danis

    2016-03-01

    Full Text Available Early T cell precursor acute lymphoblastic leukemia (ETP-ALL is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs. Inactivating alterations of Polycomb repressive complex 2 components are frequent in human ETP-ALL, but their functional role is largely undefined. We have studied the involvement of Ezh2 in a murine model of NRASQ61K-driven leukemia that recapitulates phenotypic and transcriptional features of ETP-ALL. Homozygous inactivation of Ezh2 cooperated with oncogenic NRASQ61K to accelerate leukemia onset. Inactivation of Ezh2 accentuated expression of genes highly expressed in human ETP-ALL and in normal murine early thymic progenitors. Moreover, we found that Ezh2 contributes to the silencing of stem-cell- and early-progenitor-cell-associated genes. Loss of Ezh2 also resulted in increased activation of STAT3 by tyrosine 705 phosphorylation. Our data mechanistically link Ezh2 inactivation to stem-cell-associated transcriptional programs and increased growth/survival signaling, features that convey an adverse prognosis in patients.

  6. Comparative Performance of Ground vs. Aerially Assessed RGB and Multispectral Indices for Early-Growth Evaluation of Maize Performance under Phosphorus Fertilization

    Directory of Open Access Journals (Sweden)

    Adrian Gracia-Romero

    2017-11-01

    Full Text Available Low soil fertility is one of the factors most limiting agricultural production, with phosphorus deficiency being among the main factors, particularly in developing countries. To deal with such environmental constraints, remote sensing measurements can be used to rapidly assess crop performance and to phenotype a large number of plots in a rapid and cost-effective way. We evaluated the performance of a set of remote sensing indices derived from Red-Green-Blue (RGB images and multispectral (visible and infrared data as phenotypic traits and crop monitoring tools for early assessment of maize performance under phosphorus fertilization. Thus, a set of 26 maize hybrids grown under field conditions in Zimbabwe was assayed under contrasting phosphorus fertilization conditions. Remote sensing measurements were conducted in seedlings at two different levels: at the ground and from an aerial platform. Within a particular phosphorus level, some of the RGB indices strongly correlated with grain yield. In general, RGB indices assessed at both ground and aerial levels correlated in a comparable way with grain yield except for indices a* and u*, which correlated better when assessed at the aerial level than at ground level and Greener Area (GGA which had the opposite correlation. The Normalized Difference Vegetation Index (NDVI evaluated at ground level with an active sensor also correlated better with grain yield than the NDVI derived from the multispectral camera mounted in the aerial platform. Other multispectral indices like the Soil Adjusted Vegetation Index (SAVI performed very similarly to NDVI assessed at the aerial level but overall, they correlated in a weaker manner with grain yield than the best RGB indices. This study clearly illustrates the advantage of RGB-derived indices over the more costly and time-consuming multispectral indices. Moreover, the indices best correlated with GY were in general those best correlated with leaf phosphorous content

  7. Performance: A Strategy for Professional Development in Early Childhood Teacher Preparation

    Science.gov (United States)

    Maude, Susan P.; Brotherson, Mary Jane; Summers, Jean Ann; Erwin, Elizabeth J.; Palmer, Susan; Peck, Nancy F.; Zheng, Yu Zhu; Kruse, Aryn; Haines, Shana J.; Weigel, Cindy J.

    2011-01-01

    The purpose of this article is to propose performance as a creative instructional strategy to convey complex competencies related to understanding and working effectively with families in early childhood education. Performance derives from performance ethnography, which is a qualitative research methodology. Its application to professional…

  8. PRODUCTIVITY PERFORMANCE OF ESTONIA IN A GROWTH ACCOUNTING APPROACH

    Directory of Open Access Journals (Sweden)

    Vivien MOLNAR

    2016-12-01

    Full Text Available This paper aims to contribute to a better understanding of the economic growth tendencies in Estonia and other formal post-socialist countries and the interaction between productivity growth and their determinants after the transition decades. So this paper is structured as follows. Firstly we will introduce an alternative growth accounting method to determine the components of productivity growth based on this concept. In Section we will also provide our empirical results in Estonia, Latvia, Lithuania and Hungary compared to the EU-15 countries between 1990 and 2011 how TFP (Total Factor Productivity, Physical and Labour Capital Accumulation can contribute to (increase or decrease economic performance of each country. Finally, we can conclude that the relationship between labour and output growth per capita has obviously and temporarily changed after the mid-1990s, which could be determined by the increasing role of such socio-economic factors as technological changes, capital accumulation and demographical fluctuations etc.

  9. Manipulation of the Growth Hormone-Insulin-Like Growth Factor (GH-IGF) Axis: A Treatment Strategy to Reverse the Effects of Early Life Developmental Programming.

    Science.gov (United States)

    Reynolds, Clare M; Perry, Jo K; Vickers, Mark H

    2017-08-08

    Evidence from human clinical, epidemiological, and experimental animal models has clearly highlighted a link between the early life environment and an increased risk for a range of cardiometabolic disorders in later life. In particular, altered maternal nutrition, including both undernutrition and overnutrition, spanning exposure windows that cover the period from preconception through to early infancy, clearly highlight an increased risk for a range of disorders in offspring in later life. This process, preferentially termed "developmental programming" as part of the developmental origins of health and disease (DOHaD) framework, leads to phenotypic outcomes in offspring that closely resemble those of individuals with untreated growth hormone (GH) deficiency, including increased adiposity and cardiovascular disorders. As such, the use of GH as a potential intervention strategy to mitigate the effects of developmental malprogramming has received some attention in the DOHaD field. In particular, experimental animal models have shown that early GH treatment in the setting of poor maternal nutrition can partially rescue the programmed phenotype, albeit in a sex-specific manner. Although the mechanisms remain poorly defined, they include changes to endothelial function, an altered inflammasome, changes in adipogenesis and cardiovascular function, neuroendocrine effects, and changes in the epigenetic regulation of gene expression. Similarly, GH treatment to adult offspring, where an adverse metabolic phenotype is already manifest, has shown efficacy in reversing some of the metabolic disorders arising from a poor early life environment. Components of the GH-insulin-like growth factor (IGF)-IGF binding protein (GH-IGF-IGFBP) system, including insulin-like growth factor 1 (IGF-1), have also shown promise in ameliorating programmed metabolic disorders, potentially acting via epigenetic processes including changes in miRNA profiles and altered DNA methylation. However, as

  10. Effect of nursing-calf implant timing on growth performance and carcass characteristics.

    Science.gov (United States)

    Webb, M J; Harty, A A; Salverson, R R; Kincheloe, J J; Zuelly, S M S; Underwood, K R; Luebbe, M K; Olson, K C; Blair, A D

    2017-12-01

    The objective of this study was to compare pre- and postweaning growth performance, carcass characteristics, and meat quality attributes of calves that did not receive an implant or were implanted early or late in the nursing period. Crossbred steer calves ( = 135) were stratified by birth date and birth weight and randomly assigned to the following implant treatments: control (CON; no preweaning implant), 58 d (EARLY; 36 mg zeranol, administered at an average of 58 ± 13 d of age), and 121 d (LATE; 36 mg zeranol, administered at an average 121 ± 13 d of age). After weaning, steers were blocked by initial feed yard BW to 15 pens (5 pens/treatment and 9 steers/pen). All steers were implanted on d 21 after arrival at the feed yard and again on d 108 of finishing. Steer BW and ultrasound assessment of rib eye area (uREA), rib fat thickness (uRFT), and percent intramuscular fat (uIMF) were collected when implants were administered, at weaning, and on harvest day. Carcass measurements included HCW, rib eye area (REA), 12th-rib fat thickness (FT), and marbling score. Objective color (L*, a*, and b*) was recorded, and a 3.8-cm strip loin section was removed from both sides of each carcass and portioned into 2.54-cm steaks that were aged for 3 or 14 d for analysis of cook loss and Warner-Bratzler shear force (WBSF). The remaining portion of each sample was used for analysis of moisture and crude fat. Steer BW, ADG, and G:F did not differ among treatments ( > 0.05). Steers implanted in the EARLY treatment had a greater ( 0.05); however, steers on the CON treatment had a greater ( ≤ 0.05) percent uIMF than EARLY implanted steers, whereas steers receiving the LATE implant were intermediate and not different from the other treatments. Hot carcass weight, REA, FT, USDA yield grade, marbling score, and objective color did not differ ( > 0.05) among treatments. The proportion of steers in each USDA yield and quality grade was similar ( > 0.05) among treatments, and no

  11. Growth performance and phytoremediation ability of Azolla pinnata ...

    African Journals Online (AJOL)

    ADOWIE PERE

    Growth performance and phytoremediation ability of Azolla pinnata in produced water ... Toxicity symptoms of produced water on the plant include chlorosis, frond ... easily to various conditions and can tolerate a wide ... The aquatic macrophyte used for this experiment was .... the Kathloni oilfield in northeast India.

  12. Effects of exogenous tannase enzyme on growth performance ...

    African Journals Online (AJOL)

    An experiment was conducted to study the effects of dietary addition of tannase to feed of chicks including grape pomace (GP) on growth performance, antioxidant status, immune response, blood parameters, gut morphology, intestinal microflora, liver function, and histopathological responses. The experimental diets were i) ...

  13. Employment, Economic Growth and Labor Market Performance: The Case of Turkey

    OpenAIRE

    Alparslan AKÇORAOĞLU

    2010-01-01

    The fundamental aim of this paper is to explore the empirical relationship between employment and economic growth in Turkey over the period 1995Q1-2007Q4 by using modern time series techniques. The employment growth performance is a concern for Turkey as its employment rate is well below any European Union (EU) member country. Some authors have argued that the rates of employment growth in Turkey have remained low over the same period despite relatively strong economic growth. The results of ...

  14. Characterization of Pinus pinaster seedling growth in different photo- and thermoperiods in a phytotron as a basis for early selection

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, A.; Kremer, A. [INRA, Laboratory of Forest Trees Genetics and Breeding, Cestas (France); Dormling, I. [Swedish Univ. of Agricultural Sciences, Uppsala (Sweden). Dept. of Forest Genetics

    1995-07-01

    Seedlings of Pinus pinaster families exhibiting monocyclic or polycyclic adult growth patterns, were cultivated in climate chambers during two successive growth periods separated by a period of low temperature to satisfy the chilling requirement. Six treatments combining photoperiod and temperature factors were tested. The morphology of the apex was assessed and height and biomass measured. First season seedlings grown in continuous light varied in apex morphology from the typical juvenile rosette to the adult bud usually found outdoors on 2-yr-old plants. It seems possible to distinguish monocyclic and polycyclic populations at an early stage by characters related to development and growth height. The results indicate that special environmental conditions during seedling development may be used as a tool in the search for criteria for early selection. 35 refs, 6 figs, 6 tabs

  15. THE ROLE OF MERGERS IN EARLY-TYPE GALAXY EVOLUTION AND BLACK HOLE GROWTH

    International Nuclear Information System (INIS)

    Schawinski, Kevin; Dowlin, Nathan; Urry, C. Megan; Thomas, Daniel; Edmondson, Edward

    2010-01-01

    Models of galaxy formation invoke the major merger of gas-rich progenitor galaxies as the trigger for significant phases of black hole growth and the associated feedback that suppresses star formation to create red spheroidal remnants. However, the observational evidence for the connection between mergers and active galactic nucleus (AGN) phases is not clear. We analyze a sample of low-mass early-type galaxies known to be in the process of migrating from the blue cloud to the red sequence via an AGN phase in the green valley. Using deeper imaging from Sloan Digital Sky Survey Stripe 82, we show that the fraction of objects with major morphological disturbances is high during the early starburst phase, but declines rapidly to the background level seen in quiescent early-type galaxies by the time of substantial AGN radiation several hundred Myr after the starburst. This observation empirically links the AGN activity in low-redshift early-type galaxies to a significant merger event in the recent past. The large time delay between the merger-driven starburst and the peak of AGN activity allows for the merger features to decay to the background and hence may explain the weak link between merger features and AGN activity in the literature.

  16. Monolayer-Mediated Growth of Organic Semiconductor Films with Improved Device Performance.

    Science.gov (United States)

    Huang, Lizhen; Hu, Xiaorong; Chi, Lifeng

    2015-09-15

    Increased interest in wearable and smart electronics is driving numerous research works on organic electronics. The control of film growth and patterning is of great importance when targeting high-performance organic semiconductor devices. In this Feature Article, we summarize our recent work focusing on the growth, crystallization, and device operation of organic semiconductors intermediated by ultrathin organic films (in most cases, only a monolayer). The site-selective growth, modified crystallization and morphology, and improved device performance of organic semiconductor films are demonstrated with the help of the inducing layers, including patterned and uniform Langmuir-Blodgett monolayers, crystalline ultrathin organic films, and self-assembled polymer brush films. The introduction of the inducing layers could dramatically change the diffusion of the organic semiconductors on the surface and the interactions between the active layer with the inducing layer, leading to improved aggregation/crystallization behavior and device performance.

  17. Growth Performance, Haematological Indices and Cost Benefits of ...

    African Journals Online (AJOL)

    Lenovo pc

    Effect of replacing dietary maize with cassava peel meal (CPM) supplemented with Allzyme® SSF (SSF) on the growth performance, haematological indices and cost benefits of growing pigs was investigated. Chemical composition of CPM and diets used were determined using standard procedures. Twenty-four growing ...

  18. Effects of four dim vs high intensity red color light regimens on growth performance and welfare of broilers.

    Science.gov (United States)

    Senaratna, D; Samarakone, T S; Gunawardena, W W D A

    2018-01-01

    Broilers show clear preference towards red color light (RL). However setting of an optimum light intensity is difficult since dim intensities that favor growth reduce welfare. This experiment was conducted to test the most effective RL intensity regimen (Dim [5 lux; DI] vs high [320 lux; HI]) in combination applied at different growth stages that favors for both performance and welfare. Complete randomize design was adopted with 6 replicates. Treatments were; T1 = early DI (8-21 d)+latter HI (22-35 d); T2 = early DI (8-28 d)+latter HI (29-35 d), T3 = early HI (8-21 d)+latter DI (22-35 d), T4 = early HI (8-28 d)+latter DI (29-35 d) and T5 = control (white light; WT) (8-35 d) at medium intensity (20 lux). Body weight (BW), weight gain (WG), water/feed intake and ratio, feed conversion ratios (FCR) were assessed. Common behaviours (15) were recorded by scan sampling method. Lameness, foot pad dermatitis, breast blisters, hock burning damage were assessed as welfare parameters. Fear reactions were tested using Tonic Immobility Test. Ocular and carcass evaluations were done. Meat and tibiae were analyzed for fat and bone ash respectively. On 35 d, the highest BW (2,155.72±176 g), WG (1,967.78±174 g) were recorded by T2 compared to WT (BW WT = 1,878.22±155, WG WT = 1,691.83±160). But, application of RL, either DI, or HI during early/latter stage had no significant effect on FCR. Under HI, birds showed much higher active behaviours. DI encourages eating. Though LI changed from DI to HI, same trend could be seen even under HI. The highest leg strength (218.5±120 s) was recorded by T2. The lowest leg strength (64.58±33 s) and the highest ocular weight (2.48±1 g) were recorded by T1. Significantly (plighting regimen for optimizing production, better welfare of broilers and improving health benefits of meat.

  19. Growth performance, carcass and organ characteristics of growing ...

    African Journals Online (AJOL)

    An experiment was conducted at the Department of Animal Science teaching and research farm, Bayero University Kano, to evaluate the effect of feeding graded levels of Moringa oleifera leaf meal (MOLM) in diets on growth performance, carcass and organ characteristics of weaned rabbits. Twenty eight grower rabbits of ...

  20. The early inflorescence of Arabidopsis thaliana demonstrates positional effects in floral organ growth and meristem patterning.

    Science.gov (United States)

    Plackett, Andrew R G; Powers, Stephen J; Phillips, Andy L; Wilson, Zoe A; Hedden, Peter; Thomas, Stephen G

    2018-06-01

    Linear modelling approaches detected significant gradients in organ growth and patterning across early flowers of the Arabidopsis inflorescence and uncovered evidence of new roles for gibberellin in floral development. Most flowering plants, including the genetic model Arabidopsis thaliana, produce multiple flowers in sequence from a reproductive shoot apex to form a flower spike (inflorescence). The development of individual flowers on an Arabidopsis inflorescence has typically been considered as highly stereotypical and uniform, but this assumption is contradicted by the existence of mutants with phenotypes visible in early flowers only. This phenomenon is demonstrated by mutants partially impaired in the biosynthesis of the phytohormone gibberellin (GA), in which floral organ growth is retarded in the first flowers to be produced but has recovered spontaneously by the 10th flower. We presently lack systematic data from multiple flowers across the Arabidopsis inflorescence to explain such changes. Using mutants of the GA 20-OXIDASE (GA20ox) GA biosynthesis gene family to manipulate endogenous GA levels, we investigated the dynamics of changing floral organ growth across the early Arabidopsis inflorescence (flowers 1-10). Modelling of floral organ lengths identified a significant, GA-independent gradient of increasing stamen length relative to the pistil in the wild-type inflorescence that was separable from other, GA-dependent effects. It was also found that the first flowers exhibited unstable organ patterning in contrast to later flowers and that this instability was prolonged by exogenous GA treatment. These findings indicate that the development of individual flowers is influenced by hitherto unknown factors acting across the inflorescence and also suggest novel functions for GA in floral patterning.

  1. Evaluation of operating experience for early recognition of deteriorating safety performance

    International Nuclear Information System (INIS)

    Beckmerhagen, I.A.; Berg, H.P.

    2004-01-01

    One of the most difficult challenges facing nuclear power plants is to recognize the early signs of degrading safety performance before regulatory requirements are imposed or serious incidents or accidents occur. Today, the nuclear industry is striving for collecting more information on occurrences that could improve the operational safety performance. To achieve this, the reporting threshold has been lowered from incidents to anomalies with minor or no impact to safety. Industry experience (also outside nuclear industry) has shown that these are typical issues which should be considered when looking for such early warning signs. Therefore, it is important that nuclear power plant operators have the capability to trend, analyse and recognize early warning signs of deteriorating performance. It is necessary that plant operators are sensitive to these warning signs which may not be immediately evident. Reviewing operating experience is one of the main tasks for plant operators in their daily activities. Therefore, self assessment should be at the centre of any operational safety performance programme. One way of applying a self assessment program is through the following four basic elements: operational data, events, safety basis, and related experience. This approach will be described in the paper in more details. (authors)

  2. Effects of low dose gamma radiation on the early growth of red pepper and the resistance to subsquent high dose of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Baek, M. H.; Kim, D. H.; Lee, Y. K. [KAERI, Taejon (Korea, Republic of); Lee, Y. B. [Chungnam National Univ., Taejon (Korea, Republic of)

    2001-05-01

    Red pepper (capsicum annuum L. cv. Jokwang and cv. Johong) seeds were irradiated with the dose of 0{approx}50 Gy to investigated the effect of the low dose gamma radiation on the early growth and resistance to subsequent high dose of radiation. The effect of the low dose gamma radiation on the early growth and resistance to subsequenct high dose of radiation were enhanced in Johong cultivar but not in Jokwang cultivar. Germination rate and early growth of Johong cultivar were noticeably increased at 4 Gy-, 8 Gy- and 20 Gy irradiation group. Resistance to subsequent high dose of radiation of Johong cultivar were increased at almost all of the low dose irradiation group. Especially it was highest at 4 Gy irradiation group. The carotenoid contents and enzyme activity on the resistance to subsequent high dose of radiation of Johong cultivar were increased at the 4 Gy and 8 Gy irradiation group.

  3. Conceptual basis for prescriptive growth standards from conception to early childhood: present and future.

    Science.gov (United States)

    Uauy, R; Casanello, P; Krause, B; Kuzanovic, J P; Corvalan, C

    2013-09-01

    maternal uterine environment from the time before conception, through embryonic development until fetal growth is complete. The remaining challenge is how 'early' will we be able to act, now that we can better monitor fetal growth. © 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.

  4. Early decrease in dietary protein:energy ratio by fat addition and ontogenetic changes in muscle growth mechanisms of rainbow trout: short- and long-term effects.

    Science.gov (United States)

    Alami-Durante, Hélène; Cluzeaud, Marianne; Duval, Carine; Maunas, Patrick; Girod-David, Virginia; Médale, Françoise

    2014-09-14

    As the understanding of the nutritional regulation of muscle growth mechanisms in fish is fragmentary, the present study aimed to (1) characterise ontogenetic changes in muscle growth-related genes in parallel to changes in muscle cellularity; (2) determine whether an early decrease in dietary protein:energy ratio by fat addition affects the muscle growth mechanisms of rainbow trout (Oncorhynchus mykiss) alevins; and (3) determine whether this early feeding of a high-fat (HF) diet to alevins had a long-term effect on muscle growth processes in juveniles fed a commercial diet. Developmental regulation of hyperplasia and hypertrophy was evidenced at the molecular (expression of myogenic regulatory factors, proliferating cell nuclear antigen and myosin heavy chains (MHC)) and cellular (number and diameter of white muscle fibres) levels. An early decrease in dietary protein:energy ratio by fat addition stimulated the body growth of alevins but led to a fatty phenotype, with accumulation of lipids in the anterior part, and less caudal muscle when compared at similar body weights, due to a decrease in both the white muscle hyperplasia and maximum hypertrophy of white muscle fibres. These HF diet-induced cellular changes were preceded by a very rapid down-regulation of the expression of fast-MHC. The present study also demonstrated that early dietary composition had a long-term effect on the subsequent muscle growth processes of juveniles fed a commercial diet for 3 months. When compared at similar body weights, initially HF diet-fed juveniles indeed had a lower mean diameter of white muscle fibres, a smaller number of large white muscle fibres, and lower expression levels of MyoD1 and myogenin. These findings demonstrated the strong effect of early feed composition on the muscle growth mechanisms of trout alevins and juveniles.

  5. Influence of β-galacto-oligosaccharide on growth performance and ...

    African Journals Online (AJOL)

    GOS) on growth performance, organ development and intestinal microarchitecture of broilers during heat stress. Day-old chicks (n = 125) were divided into five groups. The control or thermoneutral zone group (TNZ) was raised under standard ...

  6. Effect of type of binder on growth, digestibility, and energetic balance of Octopus maya

    OpenAIRE

    Rosas, C; Tut, J; Baeza, J; Sanchez, A; Sosa, V; Pascual, C; Arena, L; Domingues, P; Cuzon, Gerard

    2008-01-01

    The present study was designed to test the effects of type of binder on growth, nutritional physiology, total apparent digestibility, and some elements of the energetic balance of early O. maya juveniles. Two experiments were performed. One was aimed at evaluating the effect of type of binder on growth, nutritional physiology, and energetic balance and the other at knowing the effect of the binder on total apparent digestibility of O. maya. Binder type affected growth and survival of early O....

  7. Effects of early vitamin D deficiency rickets on bone and dental health, growth and immunity.

    Science.gov (United States)

    Zerofsky, Melissa; Ryder, Mark; Bhatia, Suruchi; Stephensen, Charles B; King, Janet; Fung, Ellen B

    2016-10-01

    Vitamin D deficiency is associated with adverse health outcomes, including impaired bone growth, gingival inflammation and increased risk for autoimmune disease, but the relationship between vitamin D deficiency rickets in childhood and long-term health has not been studied. In this study, we assessed the effect of early vitamin D deficiency on growth, bone density, dental health and immune function in later childhood to determine if children previously diagnosed with rickets were at greater risk of adverse health outcomes compared with healthy children. We measured serum 25-hydroxyvitamin D, calcium, parathyroid hormone, bone mineral density, anthropometric measures, dietary habits, dental health, general health history, and markers of inflammation in 14 previously diagnosed rickets case children at Children's Hospital Oakland Research Center. We compared the findings in the rickets cases with 11 healthy children selected from the population of CHO staff families. Fourteen mothers of the rickets cases, five siblings of the rickets cases, and seven mothers of healthy children also participated. Children diagnosed with vitamin D deficiency rickets had a greater risk of fracture, greater prevalence of asthma, and more dental enamel defects compared with healthy children. Given the widespread actions of vitamin D, it is likely that early-life vitamin D deficiency may increase the risk of disease later in childhood. Further assessment of the long-term health effects of early deficiency is necessary to make appropriate dietary recommendations for infants at risk of deficiency. © 2015 John Wiley & Sons Ltd.

  8. Growth performance and economics of sheep production with ...

    African Journals Online (AJOL)

    A twelve-week feeding trial was conducted using sixteen (16) growing Uda lambs to determine the growth performance of sheep fed varying levels of rice milling waste. Diets containing graded levels of rice milling waste replacing wheat offal at 15, 30 and 45% inclusion levels were formulated. Diet without rice milling waste ...

  9. Non-genetic factors affecting growth performance and carcass ...

    African Journals Online (AJOL)

    South African Journal of Animal Science ... This study was based on 20 079 and 12 169 growth and 5 406 and 2 533 carcass data collected on performance tested pigs between 1990 and 2008 from Large White and Landrace breeds ... Herd of origin, year of testing and their interaction significantly affected all traits.

  10. An association of adult personality with prenatal and early postnatal growth

    DEFF Research Database (Denmark)

    Flensborg-Madsen, Trine; Revsbech, Rasmus; Sørensen, Holger Jelling

    2014-01-01

    Abstract Background: Recent studies have noted differences in social acquiescence and interpersonal relations among adults born preterm or with very low birth weight compared to full term adults. In addition, birth weight has been observed to be negatively correlated with lie-scale scores in two ...... influence of prenatal and early postnatal development on personality growth and development. Keywords: Eysenck personality questionnaire, Lie-scale, Extraversion, Neuroticism, Psychoticism, Birth weight, Birth length, Birth head-circumference...... individuals participated in a follow-up at 20–34 years and was administered the Eysenck Personality Questionnaire (EPQ) which includes a lie-scale (indicating social acquiescence or self-insight). Associations between lie-scale scores and weight, length and head circumference respectively were analysed...

  11. Halotolerant/alkalophilic bacteria associated with the cyanobacterium Arthrospira platensis (Nordstedt Gomont that promote early growth in Sorghum bicolor (L. Moench

    Directory of Open Access Journals (Sweden)

    Gómez G. Liliana Cecilia

    2012-04-01

    Full Text Available

    Arthrospira platensis associated bacteria (APAB identified through molecuar biology like Bacillus okhensis, Indibacter alkaliphilus and Halomonas sp., are also producing 3-indol acetic acid (IAA, these bacteria was used in early plant growth promotion tests over Sorghum bicolor, these bioassay was considered indirect evidence to suggest that APAB also may have stimulatory effects over A. platensis growth naturally. I. alkaliphilus and B. okhensis enhanced early germination of S. bicolor seads, with better results than that achieved by Azospirillum brasilense, bacterium used like reference as a common plant growth promoting rizobacteria. The three APAB enhanced significative differences (P≤0.05 over morphoagronomic parameters, I. alkaliphilus and B. okhensis exhibit better resoults in elongation stimulation and root and foliage dry weight. Above evidence suggest this bacteria like plant growth promoting and it recomended testing with A. platensis axenic cultures and its associated bactteri for understanding true interaction between them.

  12. Early subtropical forest growth is driven by community mean trait values and functional diversity rather than the abiotic environment.

    Science.gov (United States)

    Kröber, Wenzel; Li, Ying; Härdtle, Werner; Ma, Keping; Schmid, Bernhard; Schmidt, Karsten; Scholten, Thomas; Seidler, Gunnar; von Oheimb, Goddert; Welk, Erik; Wirth, Christian; Bruelheide, Helge

    2015-09-01

    While functional diversity (FD) has been shown to be positively related to a number of ecosystem functions including biomass production, it may have a much less pronounced effect than that of environmental factors or species-specific properties. Leaf and wood traits can be considered particularly relevant to tree growth, as they reflect a trade-off between resources invested into growth and persistence. Our study focussed on the degree to which early forest growth was driven by FD, the environment (11 variables characterizing abiotic habitat conditions), and community-weighted mean (CWM) values of species traits in the context of a large-scale tree diversity experiment (BEF-China). Growth rates of trees with respect to crown diameter were aggregated across 231 plots (hosting between one and 23 tree species) and related to environmental variables, FD, and CWM, the latter two of which were based on 41 plant functional traits. The effects of each of the three predictor groups were analyzed separately by mixed model optimization and jointly by variance partitioning. Numerous single traits predicted plot-level tree growth, both in the models based on CWMs and FD, but none of the environmental variables was able to predict tree growth. In the best models, environment and FD explained only 4 and 31% of variation in crown growth rates, respectively, while CWM trait values explained 42%. In total, the best models accounted for 51% of crown growth. The marginal role of the selected environmental variables was unexpected, given the high topographic heterogeneity and large size of the experiment, as was the significant impact of FD, demonstrating that positive diversity effects already occur during the early stages in tree plantations.

  13. Does academic performance or personal growth share a stronger association with learning environment perception?

    Science.gov (United States)

    Tackett, Sean; Wright, Scott M.; Shochet, Robert S.

    2016-01-01

    Objectives This study was conducted to characterize the relative strength of associations of learning environment perception with academic performance and with personal growth. Methods In 2012-2014 second and third year students at Johns Hopkins University School of Medicine completed a learning environment survey and personal growth scale. Hierarchical linear regression analysis was employed to determine if the proportion of variance in learning environment scores accounted for by personal growth was significantly larger than the proportion accounted for by academic performance (course/clerkship grades). Results The proportion of variance in learning environment scores accounted for by personal growth was larger than the proportion accounted for by academic performance in year 2 [R2Δ of 0.09, F(1,175) = 14.99,  p environment scores shared a small amount of variance with academic performance in years 2 and 3.  The amount of variance between learning environment scores and personal growth was small in year 2 and large in year 3. Conclusions Since supportive learning environments are essential for medical education, future work must determine if enhancing personal growth prior to and during the clerkship year will increase learning environment perception. PMID:27570912

  14. Research on the Risk Early Warning Method of Material Supplier Performance in Power Industry

    Science.gov (United States)

    Chen, Peng; Zhang, Xi

    2018-01-01

    The early warning of supplier performance risk is still in the initial stage interiorly, and research on the early warning mechanism to identify, analyze and prevent the performance risk is few. In this paper, a new method aiming at marerial supplier performance risk in power industry is proposed, firstly, establishing a set of risk early warning indexes, Then use the ECM method to classify the indexes to form different risk grades. Then, improving Crock Ford risk quantization model by considering three indicators, including the stability of power system, economic losses and successful bid ratio to form the predictive risk grade, and ultimately using short board effect principle to form the ultimate risk grade to truly reflect the supplier performance risk. Finally, making empirical analysis on supplier performance and putting forward the counter measures and prevention strategies for different risks.

  15. Effects of different space allowances on growth performance, blood profile and pork quality in a grow-to-finish production system.

    Science.gov (United States)

    Jang, J C; Jin, X H; Hong, J S; Kim, Y Y

    2017-12-01

    This experiment was conducted to evaluate the optimal space allowance on growth performance, blood profile and pork quality of growing-finishing pigs. A total of ninety crossbred pigs [(Yorkshire×Landrace)×Duroc, 30.25±1.13 kg] were allocated into three treatments (0.96: four pigs/pen, 0.96 m2/pig; 0.80: five pigs/pen, 0.80 m2/pig; 0.69: six pigs/pen, 0.69 m2/pig) in a randomized complete block design. Pigs were housed in balanced sex and had free access to feed in all phases for 14 weeks (growing phase I, growing phase II, finishing phase I, and finishing phase II). There was no statistical difference in growing phase, but a linear decrease was observed on average daily gain (ADG, pspace allowance in late finishing phase. On the other hand, a quadratic effect was observed on gain to feed ratio in early finishing phase (pspace allowance (pspace allowance. Floor area allowance did not affect pork colors, but shear force linearly increased as floor space decreased (pspace allocation. Serum IgG was linearly ameliorated as space allowance increased on 10 week (pspace allowance deteriorates the immune system as well as growth performance of pigs, resulting in poor pork quality. Recommended adequate space allowance in a grow-to-finish production system is more than 0.80 m2/pig for maximizing growth performance and production efficiency.

  16. Migrant Preschool Children's School Readiness and Early Elementary School Performance

    Science.gov (United States)

    Tavassolie, Tanya; López, Claudia; De Feyter, Jessica; Hartman, Suzanne C.; Winsler, Adam

    2018-01-01

    Little is known about the early educational performance of children in migrant farmworker families. The authors examined the school readiness and early school success of 289 four-year-old preschool children of migrant families attending Redlands Christian Migrant Association centers. Children's school readiness was assessed and public school…

  17. Effects of different housing systems on growth performance and ...

    African Journals Online (AJOL)

    Effects of different housing systems on growth performance and carcass yield of two breeds of turkey. ... Bulletin of Animal Health and Production in Africa ... The results on carcass yield showed a significantly (p<0.05) higher plucked weight ...

  18. Deiodinase knockdown during early zebrafish development affects growth, development, energy metabolism, motility and phototransduction.

    Directory of Open Access Journals (Sweden)

    Enise Bagci

    Full Text Available Thyroid hormone (TH balance is essential for vertebrate development. Deiodinase type 1 (D1 and type 2 (D2 increase and deiodinase type 3 (D3 decreases local intracellular levels of T3, the most important active TH. The role of deiodinase-mediated TH effects in early vertebrate development is only partially understood. Therefore, we investigated the role of deiodinases during early development of zebrafish until 96 hours post fertilization at the level of the transcriptome (microarray, biochemistry, morphology and physiology using morpholino (MO knockdown. Knockdown of D1+D2 (D1D2MO and knockdown of D3 (D3MO both resulted in transcriptional regulation of energy metabolism and (muscle development in abdomen and tail, together with reduced growth, impaired swim bladder inflation, reduced protein content and reduced motility. The reduced growth and impaired swim bladder inflation in D1D2MO could be due to lower levels of T3 which is known to drive growth and development. The pronounced upregulation of a large number of transcripts coding for key proteins in ATP-producing pathways in D1D2MO could reflect a compensatory response to a decreased metabolic rate, also typically linked to hypothyroidism. Compared to D1D2MO, the effects were more pronounced or more frequent in D3MO, in which hyperthyroidism is expected. More specifically, increased heart rate, delayed hatching and increased carbohydrate content were observed only in D3MO. An increase of the metabolic rate, a decrease of the metabolic efficiency and a stimulation of gluconeogenesis using amino acids as substrates may have been involved in the observed reduced protein content, growth and motility in D3MO larvae. Furthermore, expression of transcripts involved in purine metabolism coupled to vision was decreased in both knockdown conditions, suggesting that both may impair vision. This study provides new insights, not only into the role of deiodinases, but also into the importance of a correct

  19. Degradation of seed mucilage by soil microflora promotes early seedling growth of a desert sand dune plant.

    Science.gov (United States)

    Yang, Xuejun; Baskin, Carol C; Baskin, Jerry M; Zhang, Wenhao; Huang, Zhenying

    2012-05-01

    In contrast to the extensive understanding of seed mucilage biosynthesis, much less is known about how mucilage is biodegraded and what role it plays in the soil where seeds germinate. We studied seed mucilage biodegradation by a natural microbial community. High-performance anion-exchange chromatography (HPAEC) was used to determine monosaccharide composition in achene mucilage of Artemisia sphaerocephala. Mucilage degradation by the soil microbial community from natural habitats was examined by monosaccharide utilization tests using Biolog plates, chemical assays and phospholipid fatty acid (PLFA) analysis. Glucose (29.4%), mannose (20.3%) and arabinose (19.5%) were found to be the main components of achene mucilage. The mucilage was biodegraded to CO(2) and soluble sugars, and an increase in soil microbial biomass was observed during biodegradation. Fluorescence microscopy showed the presence of mucilage (or its derivatives) in seedling tissues after growth with fluorescein isothiocyanate (FITC)-labelled mucilage. The biodegradation also promoted early seedling growth in barren sand dunes, which was associated with a large soil microbial community that supplies substances promoting seedling establishment. We conclude that biodegradation of seed mucilage can play an ecologically important role in the life cycles of plants especially in harsh desert environments to which A. sphaerocephala is well-adapted. © 2011 Blackwell Publishing Ltd.

  20. Conventional and Piecewise Growth Modeling Techniques: Applications and Implications for Investigating Head Start Children's Early Literacy Learning

    Science.gov (United States)

    Hindman, Annemarie H.; Cromley, Jennifer G.; Skibbe, Lori E.; Miller, Alison L.

    2011-01-01

    This article reviews the mechanics of conventional and piecewise growth models to demonstrate the unique affordances of each technique for examining the nature and predictors of children's early literacy learning during the transition from preschool through first grade. Using the nationally representative Family and Child Experiences Survey…

  1. Working memory and fine motor skills predict early numeracy performance of children with cerebral palsy.

    Science.gov (United States)

    Van Rooijen, Maaike; Verhoeven, Ludo; Steenbergen, Bert

    2016-01-01

    Early numeracy is an important precursor for arithmetic performance, academic proficiency, and work success. Besides their apparent motor difficulties, children with cerebral palsy (CP) often show additional cognitive disturbances. In this study, we examine whether working memory, non-verbal intelligence, linguistic skills, counting and fine motor skills are positively related to the early numeracy performance of 6-year-old children with CP. A total of 56 children (M = 6.0, SD = 0.61, 37 boys) from Dutch special education schools participated in this cross-sectional study. Of the total group, 81% of the children have the spastic type of CP (33% unilateral and 66% bilateral), 9% have been diagnosed as having diskinetic CP, 8% have been diagnosed as having spastic and diskinetic CP and 2% have been diagnosed as having a combination of diskinetic and atactic CP. The children completed standardized tests assessing early numeracy performance, working memory, non-verbal intelligence, sentence understanding and fine motor skills. In addition, an experimental task was administered to examine their basic counting performance. Structural equation modeling showed that working memory and fine motor skills were significantly related to the early numeracy performance of the children (β = .79 and p working memory and early numeracy (β = .57, p working memory for early numeracy performance in children with CP and they warrant further research into the efficacy of intervention programs aimed at working memory training.

  2. A Methodology for Making Early Comparative Architecture Performance Evaluations

    Science.gov (United States)

    Doyle, Gerald S.

    2010-01-01

    Complex and expensive systems' development suffers from a lack of method for making good system-architecture-selection decisions early in the development process. Failure to make a good system-architecture-selection decision increases the risk that a development effort will not meet cost, performance and schedule goals. This research provides a…

  3. Effects of gamma ray irradiation on early growth of soybean (Glycine mac (L). Merrill)

    International Nuclear Information System (INIS)

    Lilik Harsanti; Yulidar

    2015-01-01

    Increase my in domestic soybean production is one of the government's program to reduce dependence on imported soybeans and soybean efforts to achieve self-sufficiency in 2015. An experiment has been conducted to study the effects of gamma ray irradiation of of 60 Cobalt on early growth of soybean seed. Variety Denna 2 varieties have been irradiated by gamma rays with 0 Gy, 200 Gy, 300 Gy, 400 Gy doses, and then planted in green house on Ps Jumat PAIR-BATAN. Plant growth from each doses is proved to be varied. From germination viability on the third day, the highest percentage of seedling with leaves is on 100 Gy dose (73.75%), and 7, 14 and 21 day the lowest is on dose 400 Gy. (author)

  4. The effects of maternal calving date and calving interval on growth ...

    African Journals Online (AJOL)

    This study was undertaken to investigate the growth performance of calves born to dams with different calving dates and calving intervals. Early calving dams produced calves with the lowest birth weights, the highest actual weaning weights and the highest pre-breeding heifer weights. The higher weaning weights of early ...

  5. Essays on predictability of emerging markets growth and financial performance

    OpenAIRE

    Banegas, Maria Ayelen

    2011-01-01

    This dissertation seeks to better understand the underlying factors driving financial performance and economic activity in international markets. The first chapter "Predictability of Growth in Emerging Markets: Information in Financial Aggregates" tests for predictability of output growth in a panel of twenty-two emerging market economies. I use pooled panel data methods that control for endogeneity and persistence in the predictor variables to test the predictive power of a large set of fina...

  6. A prospective observational study of early fetal growth velocity and its association with birth weight, gestational age at delivery, preeclampsia, and perinatal mortality

    Energy Technology Data Exchange (ETDEWEB)

    Vasudeva, Akhila, E-mail: akhilavasudeva@gmail.com [Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka State (India); Abraham, Anu Annie, E-mail: anuannieabraham@yahoo.com [Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal University, Manipal 576104, Karnataka State (India); Kamath, Asha, E-mail: aashakamat@gmail.com [Department of Community Medicine, Kasturba Medical College, Manipal, A Constituent College of Manipal University (India)

    2013-08-15

    Objectives: We aimed to measure early fetal growth velocity and to correlate this with the birth weight, gestational age at delivery, and with the incidence of adverse pregnancy outcomes specifically preeclampsia and perinatal mortality. Methods: A data based prospective observational study, wherein sonographic biometry data and specific pregnancy outcome related data were collected from pregnant women's records, starting soon after their first antenatal visit. Early fetal growth velocity was measured using BPD growth between 11 and 14 weeks scan and anomaly scan and standardizing this by Z scoring. Results: Out of 607 fetuses, 41 (6.7%) were slow growing, 531 (87.4%) normally growing, and 35 (5.7%) fast growing (Z scoring <10th{sup ,} 10–90th, and >90th percentiles respectively). As fetal growth velocity increased, the mean birth weight decreased from 2958.7 ± 388.9 (<10th centile), 2742.1 ± 576.6 (10–90th centile), to 2339.3 ± 729.4 (>90th centile); and gestational age at delivery decreased from 38.5 ± 1.3 (<10th centile), 37.5 ± 2.1 (10–90th centile), to 36.4 ± 2.2 (>90th centile), and both these trends were statistically significant (p < 0.001).Faster growing fetuses had a higher risk of preterm delivery(spontaneous + indicated) compared to other 2 groups [OR 4.42 (2.18,8.98)], and slower growing fetuses had a higher risk of postdated deliveries compared to other 2 groups [OR 3.042 (1.44, 6.45)].We found no significant association between early fetal growth velocity and incidence of small for gestational age at birth/low birth weight at term, preeclampsia, and perinatal mortality. Conclusions: Early fetal growth velocity between first and second trimesters, may be one of the important factors influencing ultimate birthweight and gestational age at delivery.

  7. A prospective observational study of early fetal growth velocity and its association with birth weight, gestational age at delivery, preeclampsia, and perinatal mortality

    International Nuclear Information System (INIS)

    Vasudeva, Akhila; Abraham, Anu Annie; Kamath, Asha

    2013-01-01

    Objectives: We aimed to measure early fetal growth velocity and to correlate this with the birth weight, gestational age at delivery, and with the incidence of adverse pregnancy outcomes specifically preeclampsia and perinatal mortality. Methods: A data based prospective observational study, wherein sonographic biometry data and specific pregnancy outcome related data were collected from pregnant women's records, starting soon after their first antenatal visit. Early fetal growth velocity was measured using BPD growth between 11 and 14 weeks scan and anomaly scan and standardizing this by Z scoring. Results: Out of 607 fetuses, 41 (6.7%) were slow growing, 531 (87.4%) normally growing, and 35 (5.7%) fast growing (Z scoring <10th , 10–90th, and >90th percentiles respectively). As fetal growth velocity increased, the mean birth weight decreased from 2958.7 ± 388.9 (<10th centile), 2742.1 ± 576.6 (10–90th centile), to 2339.3 ± 729.4 (>90th centile); and gestational age at delivery decreased from 38.5 ± 1.3 (<10th centile), 37.5 ± 2.1 (10–90th centile), to 36.4 ± 2.2 (>90th centile), and both these trends were statistically significant (p < 0.001).Faster growing fetuses had a higher risk of preterm delivery(spontaneous + indicated) compared to other 2 groups [OR 4.42 (2.18,8.98)], and slower growing fetuses had a higher risk of postdated deliveries compared to other 2 groups [OR 3.042 (1.44, 6.45)].We found no significant association between early fetal growth velocity and incidence of small for gestational age at birth/low birth weight at term, preeclampsia, and perinatal mortality. Conclusions: Early fetal growth velocity between first and second trimesters, may be one of the important factors influencing ultimate birthweight and gestational age at delivery

  8. The Impact of Early Life Stress on Growth and Cardiovascular Risk: A Possible Example for Autonomic Imprinting?

    Science.gov (United States)

    Buchhorn, Reiner; Meint, Sebastian; Willaschek, Christian

    2016-01-01

    Early life stress is imprinting regulatory properties with life-long consequences. We investigated heart rate variability in a group of small children with height below the third percentile, who experienced an episode of early life stress due to heart failure or intra uterine growth retardation. These children appear to develop autonomic dysfunction in later life. Compared to the healthy control group heart rate variability (HRV) is reduced on average in a group of 101 children with short stature. Low HRV correlates to groups of children born small for gestational age (SGA), children with cardiac growth failure and children with congenital syndromes, but not to those with constitutional growth delay (CGD), who had normal HRV. Reduced HRV indicated by lower RMSSD and High Frequency (HF)-Power is indicating reduced vagal activity as a sign of autonomic imbalance. It is not short stature itself, but rather the underlying diseases that are the cause for reduced HRV in children with height below the third percentile. These high risk children-allocated in the groups with an adverse autonomic imprinting in utero or infancy (SGA, congenital heart disease and congenital syndromes)-have the highest risk for 'stress diseases' such as cardiovascular disease in later life. The incidence of attention deficit disorder is remarkably high in our group of short children.

  9. the relationship of birth status and early reproductive performance ...

    African Journals Online (AJOL)

    The effectiveness of selection for improvement in reproductive performance of sheep depends on measure- ment at any early age. For this reason selection of rams and ewes on their birth status, (single or twin), (Kennedy,. 1967; Turner, Hayman, Triffitt and Prunster, 1969), and ewes having multiple births during their first or ...

  10. Prunus necrotic ringspot virus Early Invasion and Its Effects on Apricot Pollen Grain Performance.

    Science.gov (United States)

    Amari, Khalid; Burgos, Lorenzo; Pallas, Vicente; Sanchez-Pina, María Amelia

    2007-08-01

    ABSTRACT The route of infection and the pattern of distribution of Prunus necrotic ringspot virus (PNRSV) in apricot pollen were studied. PNRSV was detected both within and on the surface of infected pollen grains. The virus invaded pollen during its early developmental stages, being detected in pollen mother cells. It was distributed uniformly within the cytoplasm of uni- and bicellular pollen grains and infected the generative cell. In mature pollen grains, characterized by their triangular shape, the virus was located mainly at the apertures, suggesting that PNRSV distribution follows the same pattern as the cellular components required for pollen tube germination and cell wall tube synthesis. PNRSV also was localized inside pollen tubes, especially in the growth zone. In vitro experiments demonstrated that infection with PNRSV decreases the germination percentage of pollen grains by more than half and delays the growth of pollen tubes by approximately 24 h. However, although PNRSV infection affected apricot pollen grain performance during germination, the presence of the virus did not completely prevent fertilization, because the infected apricot pollen tubes, once germinated, were able to reach the apricot embryo sacs, which, in the climatic conditions of southeastern Spain, mature later than in other climates. Thus, infected pollen still could play an important role in the vertical transmission of PNRSV in apricot.

  11. Growth of Korean preterm infants in a family-centered tradition during early infancy: the influence of health risks, maternal employment, and the sex of infants.

    Science.gov (United States)

    Ahn, Youngmee; Sohn, Min; Lee, Sangmi

    2014-10-01

    The physical growth of mild preterm infants (maternal employment status, and the infant sex. There were four noteworthy findings on growth variation in Korean mild preterm infants during early infancy: (i) the secular trend of intrauterine growth; (ii) the cumulative adverse effects of four risk factors; (iii) the possible burden of maternal employment if insufficient support; and (iv) the possibility of the cultural favoritism to male infants regardless of the modern industrialized society. The study suggests that, in a modern society, while mild preterm infants could sustain typical fetal growth, the early postnatal growth may vary based on health risks and sociocultural circumstances related to child-bearing and -rearing practices surrounding them. © 2013 The Authors. Japan Journal of Nursing Science © 2013 Japan Academy of Nursing Science.

  12. Growth performance and nutrient quality of three Moringa oleifera ...

    African Journals Online (AJOL)

    Growth performance and nutrient quality of three Moringa oleifera accessions grown as potherbs under varied manure rates and watering intervals were investigated at the Department of Crop Science, University of Nigeria, Nsukka. The treatments included three accessions of Moringa (Awo-Anaekpa, Idere and Kano), ...

  13. Evaluation of Growth Performance of Tomato in Response to ...

    African Journals Online (AJOL)

    Sunusi

    ABSTRACT. Field experiment was conducted in 2013 and 2014 to evaluate growth performance of two tomato genotypes in response to biochar application and arbuscular mycorrhizal fungal (AMF) inoculation at the. Teaching and Research Farm, Federal University of Agriculture, Abeokuta. The experiment was laid out.

  14. Effects of early thyroxine treatment on development and growth at age 10.7 years: follow-up of a randomized placebo-controlled trial in children with Down's syndrome

    NARCIS (Netherlands)

    Marchal, Jan Pieter; Maurice-Stam, Heleen; Ikelaar, Nadine A.; Klouwer, Femke C. C.; Verhorstert, Kim W. J.; Witteveen, M. Emma; Houtzager, Bregje A.; Grootenhuis, Martha A.; van Trotsenburg, A. S. Paul

    2014-01-01

    In 2-year-old children with Down's syndrome (DS), early T4 treatment was found to result in slightly better motor development and growth. This study sought to determine long-term effects of early T4 treatment on development and growth in children with DS with either an elevated or normal neonatal

  15. Long-term consequences of nutrition and growth in early childhood and possible preventive interventions.

    Science.gov (United States)

    Adair, Linda S

    2014-01-01

    Maternal nutritional deficiencies and excesses during pregnancy, and faster infant weight gain in the first 2 years of life are associated with increased risk of noncommunicable diseases (NCDs) in adulthood. The first 1,000 days of life (from conception until the child reaches age 2 years) represent a vulnerable period for programming of NCD risk, and are an important target for prevention of adult disease. This paper takes a developmental perspective to identify periconception, pregnancy, and infancy nutritional stressors, and to discuss mechanisms through which they influence later disease risk with the goal of informing age-specific interventions. Low- and middle-income countries need to address the dual burden of under- and overnutrition by implementing interventions to promote growth and enhance survival and intellectual development without increasing chronic disease risk. In the absence of good evidence from long-term follow-up of early life interventions, current recommendations for early life prevention of adult disease presume that interventions designed to optimize pregnancy outcomes and promote healthy infant growth and development will also reduce chronic disease risk. These include an emphasis on optimizing maternal nutrition prior to pregnancy, micronutrient adequacy in the preconception period and during pregnancy, promotion of breastfeeding and high-quality complementary foods, and prevention of obesity in childhood and adolescence. © 2014 Nestec Ltd., Vevey/S. Karger AG, Basel.

  16. The growth performance of F1 transgenic mutiara catfish

    Science.gov (United States)

    Iskandar; Buwono, I. D.; Agung, M. U. K.

    2018-04-01

    The growth of catfish (African or Sangkuriang strain) these days is tend to decreased. One of the solutions due to this problem is to improve the genetics of growth using transgenesis technology, toward more profitable. The specific objective of the research is to detect the transmission of exogenous GH (African catfish GH inserts) inside the F1 transgenic Mutiara catfish using PCR (Polymerase Chain Reaction) method and to evaluate the growth performance of transgenic Mutiara catfish made using the parameters of feed conversion (FCR = Feed Conversion Ratio). Transgenic catfish (strain mutiara) F0 and F1 carried African catfish GH (600 bp) can be produced. Superiority characters of transgenic catfish represented heritability (h2 ) and heterosis (H), indicating that the offspring of hybrid F1 transgenic mutiara catfish had phenotypes rapid growth (h2 = 17.55 % and H = 42.83 %) compared to non-transgenic catfish (h 2 = 10.07 % and H = 18.56 %). Evaluation of the efficiency of feed use parameters feed conversion ratio, shows that F1 transgenic mutiara catfish (FCR = 0.85) more efficient in converting feed into meat.

  17. Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8-18 years of IVF children and spontaneously conceived controls born to subfertile parents.

    Science.gov (United States)

    Ceelen, Manon; van Weissenbruch, Mirjam M; Prein, Janneke; Smit, Judith J; Vermeiden, Jan P W; Spreeuwenberg, Marieke; van Leeuwen, Flora E; Delemarre-van de Waal, Henriette A

    2009-11-01

    Little is known about post-natal growth in IVF offspring and the effects of rates of early post-natal growth on blood pressure and body fat composition during childhood and adolescence. The follow-up study comprised 233 IVF children aged 8-18 years and 233 spontaneously conceived controls born to subfertile parents. Growth data from birth to 4 years of age, available for 392 children (n = 193 IVF, n = 199 control), were used to study early post-natal growth. Furthermore, early post-natal growth velocity (weight gain) was related to blood pressure and skinfold measurements at follow-up. We found significantly lower weight, height and BMI standard deviation scores (SDSs) at 3 months, and weight SDS at 6 months of age in IVF children compared with controls. Likewise, IVF children demonstrated a greater gain in weight SDS (P pressure in IVF children (P = 0.014 systolic, 0.04 diastolic) but not in controls. Growth during late infancy was not related to skinfold thickness in IVF children, unlike controls (P = 0.002 peripheral sum, 0.003 total sum). Growth during early childhood was related to skinfold thickness in both IVF and controls (P = 0.005 and 0.01 peripheral sum and P = 0.003 and 0.005 total sum, respectively). Late infancy growth velocity of IVF children was significantly higher compared with controls. Nevertheless, early childhood growth instead of infancy growth seemed to predict cardiovascular risk factors in IVF children. Further research is needed to confirm these findings and to follow-up growth and development of IVF children into adulthood.

  18. Influence of establishment timing and planting stock on early rotational growth of loblolly pine plantations in Texas

    Science.gov (United States)

    M. A. Blazier; E. L. Taylor; A. G. Holley

    2010-01-01

    Planting container seedlings, which have relatively fully formed root systems encased in a soil-filled plug, may improve loblolly pine plantation productivity by increasing early survival and growth relative to that of conventionally planted bareroot seedlings. Planting seedlings in fall may also confer productivity increases to loblolly pine plantations by giving...

  19. Early Life Conditions and Physiological Stress following the Transition to Farming in Central/Southeast Europe: Skeletal Growth Impairment and 6000 Years of Gradual Recovery.

    Directory of Open Access Journals (Sweden)

    Alison A Macintosh

    Full Text Available Early life conditions play an important role in determining adult body size. In particular, childhood malnutrition and disease can elicit growth delays and affect adult body size if severe or prolonged enough. In the earliest stages of farming, skeletal growth impairment and small adult body size are often documented relative to hunter-gatherer groups, though this pattern is regionally variable. In Central/Southeast Europe, it is unclear how early life stress, growth history, and adult body size were impacted by the introduction of agriculture and ensuing long-term demographic, social, and behavioral change. The current study assesses this impact through the reconstruction and analysis of mean stature, body mass, limb proportion indices, and sexual dimorphism among 407 skeletally mature men and women from foraging and farming populations spanning the Late Mesolithic through Early Medieval periods in Central/Southeast Europe (~7100 calBC to 850 AD. Results document significantly reduced mean stature, body mass, and crural index in Neolithic agriculturalists relative both to Late Mesolithic hunter-gatherer-fishers and to later farming populations. This indication of relative growth impairment in the Neolithic, particularly among women, is supported by existing evidence of high developmental stress, intensive physical activity, and variable access to animal protein in these early agricultural populations. Among subsequent agriculturalists, temporal increases in mean stature, body mass, and crural index were more pronounced among Central European women, driving declines in the magnitude of sexual dimorphism through time. Overall, results suggest that the transition to agriculture in Central/Southeast Europe was challenging for early farming populations, but was followed by gradual amelioration across thousands of years, particularly among Central European women. This sex difference may be indicative, in part, of greater temporal variation in the

  20. Early Life Conditions and Physiological Stress following the Transition to Farming in Central/Southeast Europe: Skeletal Growth Impairment and 6000 Years of Gradual Recovery

    Science.gov (United States)

    Macintosh, Alison A.; Pinhasi, Ron; Stock, Jay T.

    2016-01-01

    Early life conditions play an important role in determining adult body size. In particular, childhood malnutrition and disease can elicit growth delays and affect adult body size if severe or prolonged enough. In the earliest stages of farming, skeletal growth impairment and small adult body size are often documented relative to hunter-gatherer groups, though this pattern is regionally variable. In Central/Southeast Europe, it is unclear how early life stress, growth history, and adult body size were impacted by the introduction of agriculture and ensuing long-term demographic, social, and behavioral change. The current study assesses this impact through the reconstruction and analysis of mean stature, body mass, limb proportion indices, and sexual dimorphism among 407 skeletally mature men and women from foraging and farming populations spanning the Late Mesolithic through Early Medieval periods in Central/Southeast Europe (~7100 calBC to 850 AD). Results document significantly reduced mean stature, body mass, and crural index in Neolithic agriculturalists relative both to Late Mesolithic hunter-gatherer-fishers and to later farming populations. This indication of relative growth impairment in the Neolithic, particularly among women, is supported by existing evidence of high developmental stress, intensive physical activity, and variable access to animal protein in these early agricultural populations. Among subsequent agriculturalists, temporal increases in mean stature, body mass, and crural index were more pronounced among Central European women, driving declines in the magnitude of sexual dimorphism through time. Overall, results suggest that the transition to agriculture in Central/Southeast Europe was challenging for early farming populations, but was followed by gradual amelioration across thousands of years, particularly among Central European women. This sex difference may be indicative, in part, of greater temporal variation in the social status afforded

  1. 215 mandible fractures in 120 children: demographics, treatment, outcomes, and early growth data.

    Science.gov (United States)

    Smith, Darren M; Bykowski, Michael R; Cray, James J; Naran, Sanjay; Rottgers, S Alex; Shakir, Sameer; Vecchione, Lisa; Schuster, Lindsay; Losee, Joseph E

    2013-06-01

    Optimal management of pediatric mandible fractures demands that the practitioner balance reduction and fixation with preservation of growth potential and function. The ideal synthesis of these goals has not yet been defined. The authors catalogue their experience with pediatric mandible fractures at a major pediatric teaching hospital with reference to demographics, injury type, treatment, and outcomes to inform future management of these injuries. Demographics, management, and outcomes of pediatric mandible fractures presenting over 10 years at a pediatric trauma center were assessed. Cephalometric analysis was conducted. Relationships among demographics, fracture type, management, outcomes, and growth were explored. Two hundred fifteen mandible fractures in 120 patients younger than 18 years were analyzed (average follow-up, 19.5 months). The condylar head and neck were fractured most frequently. Operative management was significantly more likely for children older than 12 years (pfractures were significantly associated with a higher rate of adverse outcomes (pmandibular function by patient or surgeon. No significant growth differences existed on cephalometric analysis between our cohort and age- and sex-matched controls (p>0.05). This study reports the demographics, treatment, and early follow-up of a sizable cohort of pediatric mandible fractures. Management principles for these injuries are outlined. Although definitive recommendations must be withheld until longer follow-up is available, the data presented here show that the treatment protocols used at the authors' center have yielded largely uncompromised mandibular function and growth thus far.

  2. [Pubertal growth of 1,453 healthy children according to age at pubertal growth spurt onset. The Barcelona longitudinal growth study].

    Science.gov (United States)

    Carrascosa, Antonio; Yeste, Diego; Moreno-Galdó, Antonio; Gussinyé, Miquel; Ferrández, Ángel; Clemente, María; Fernández-Cancio, Mónica

    2018-02-20

    Pubertal growth pattern differs according to age at pubertal growth spurt onset which occurs over a five years period (girls: 8-13 years, boys: 10-15 years). The need for more than one pubertal reference pattern has been proposed. We aimed to obtain five 1-year-age-interval pubertal patterns. Longitudinal (6 years of age-adult height) growth study of 1,453 healthy children to evaluate height-for-age, growth velocity-for-age and weight-for-age values. According to age at pubertal growth spurt onset girls were considered: very-early matures (8-9 years, n=119), early matures (9-10 years, n=157), intermediate matures (10-11 years, n=238), late matures (11-12 years, n=127) and very-late matures (12-13 years, n=102), and boys: very-early matures (10-11 years, n=110), early matures (11-12 years, n=139), intermediate matures (12-13 years, n=225), late matures (13-14 years, n=133) and very-late matures (14-15 years, n=103). Age at menarche and growth up to adult height were recorded. In both sexes, statistically-significant (P<.0001) and clinically-pertinent differences in pubertal growth pattern (mean height-for-age, mean growth velocity-for-age and mean pubertal height gain, values) were found among the five pubertal maturity groups and between each group and the whole population, despite similar adult height values. The same occurred for age at menarche and growth from menarche to adult height (P<.05). In both sexes, pubertal growth spurt onset is a critical milestone determining pubertal growth and sexual development. The contribution of our data to better clinical evaluation of growth according to the pubertal maturity tempo of each child will obviate the mistakes made when only one pubertal growth reference is used. Copyright © 2018. Publicado por Elsevier España, S.L.U.

  3. Identification of water use strategies at early growth stages in durum wheat from shoot phenotyping and physiological measurements.

    Directory of Open Access Journals (Sweden)

    ALIREZA NAKHFOROOSH

    2016-08-01

    Full Text Available Modern imaging technology provides new approaches to plant phenotyping for traits relevant to crop yield and resource efficiency. Our objective was to investigate water use strategies at early growth stages in durum wheat genetic resources using shoot imaging at the ScreenHouse phenotyping facility combined with physiological measurements. 12 durum landraces from different pedoclimatic backgrounds were compared to three modern check cultivars in a greenhouse pot experiment under well watered (75 % plant available water, PAW and drought (25 % PAW conditions. Transpiration rate was analyzed for the underlying main morphological (leaf area duration and physiological (stomata conductance factors. Combining both morphological and physiological regulation of transpiration, four distinct water use types were identified. Most landraces had high transpiration rates either due to extensive leaf area (area types or both large leaf areas together with high stomata conductance (spender types. All modern cultivars were distinguished by high stomata conductance with comparatively compact canopies (conductance types. Only few landraces were water saver types with both small canopy and low stomata conductance. During early growth, genotypes with large leaf area had high dry-matter accumulation under both well watered and drought conditions compared to genotypes with compact stature. However, high stomata conductance was the basis to achieve high dry matter per unit leaf area, indicating high assimilation capacity as a key for productivity in modern cultivars. We conclude that the identified water use strategies based on early growth shoot phenotyping combined with stomata conductance provide an appropriate framework for targeted selection of distinct pre-breeding material adapted to different types of water limited environments.

  4. Identification of Water Use Strategies at Early Growth Stages in Durum Wheat from Shoot Phenotyping and Physiological Measurements

    Science.gov (United States)

    Nakhforoosh, Alireza; Bodewein, Thomas; Fiorani, Fabio; Bodner, Gernot

    2016-01-01

    Modern imaging technology provides new approaches to plant phenotyping for traits relevant to crop yield and resource efficiency. Our objective was to investigate water use strategies at early growth stages in durum wheat genetic resources using shoot imaging at the ScreenHouse phenotyping facility combined with physiological measurements. Twelve durum landraces from different pedoclimatic backgrounds were compared to three modern check cultivars in a greenhouse pot experiment under well-watered (75% plant available water, PAW) and drought (25% PAW) conditions. Transpiration rate was analyzed for the underlying main morphological (leaf area duration) and physiological (stomata conductance) factors. Combining both morphological and physiological regulation of transpiration, four distinct water use types were identified. Most landraces had high transpiration rates either due to extensive leaf area (area types) or both large leaf areas together with high stomata conductance (spender types). All modern cultivars were distinguished by high stomata conductance with comparatively compact canopies (conductance types). Only few landraces were water saver types with both small canopy and low stomata conductance. During early growth, genotypes with large leaf area had high dry-matter accumulation under both well-watered and drought conditions compared to genotypes with compact stature. However, high stomata conductance was the basis to achieve high dry matter per unit leaf area, indicating high assimilation capacity as a key for productivity in modern cultivars. We conclude that the identified water use strategies based on early growth shoot phenotyping combined with stomata conductance provide an appropriate framework for targeted selection of distinct pre-breeding material adapted to different types of water limited environments. PMID:27547208

  5. Nucleotide polymorphisms in a pine ortholog of the Arabidopsis degrading enzyme cellulase KORRIGAN are associated with early growth performance in Pinus pinaster.

    Science.gov (United States)

    Cabezas, José Antonio; González-Martínez, Santiago C; Collada, Carmen; Guevara, María Angeles; Boury, Christophe; de María, Nuria; Eveno, Emmanuelle; Aranda, Ismael; Garnier-Géré, Pauline H; Brach, Jean; Alía, Ricardo; Plomion, Christophe; Cervera, María Teresa

    2015-09-01

    We have carried out a candidate-gene-based association genetic study in Pinus pinaster Aiton and evaluated the predictive performance for genetic merit gain of the most significantly associated genes and single nucleotide polymorphisms (SNPs). We used a second generation 384-SNP array enriched with candidate genes for growth and wood properties to genotype mother trees collected in 20 natural populations covering most of the European distribution of the species. Phenotypic data for total height, polycyclism, root-collar diameter and biomass were obtained from a replicated provenance-progeny trial located in two sites with contrasting environments (Atlantic vs Mediterranean climate). General linear models identified strong associations between growth traits (total height and polycyclism) and four SNPs from the korrigan candidate gene, after multiple testing corrections using false discovery rate. The combined genomic breeding value predictions assessed for the four associated korrigan SNPs by ridge regression-best linear unbiased prediction (RR-BLUP) and cross-validation accounted for up to 8 and 15% of the phenotypic variance for height and polycyclic growth, respectively, and did not improve adding SNPs from other growth-related candidate genes. For root-collar diameter and total biomass, they accounted for 1.6 and 1.1% of the phenotypic variance, respectively, but increased to 15 and 4.1% when other SNPs from lp3.1, lp3.3 and cad were included in RR-BLUP models. These results point towards a desirable integration of candidate-gene studies as a means to pre-select relevant markers, and aid genomic selection in maritime pine breeding programs. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  6. Early-Life Telomere Dynamics Differ between the Sexes and Predict Growth in the Barn Swallow (Hirundo rustica.

    Directory of Open Access Journals (Sweden)

    Marco Parolini

    Full Text Available Telomeres are conserved DNA-protein structures at the termini of eukaryotic chromosomes which contribute to maintenance of genome integrity, and their shortening leads to cell senescence, with negative consequences for organismal functions. Because telomere erosion is influenced by extrinsic and endogenous factors, telomere dynamics may provide a mechanistic basis for evolutionary and physiological trade-offs. Yet, knowledge of fundamental aspects of telomere biology under natural selection regimes, including sex- and context-dependent variation in early-life, and the covariation between telomere dynamics and growth, is scant. In this study of barn swallows (Hirundo rustica we investigated the sex-dependent telomere erosion during nestling period, and the covariation between relative telomere length and body and plumage growth. Finally, we tested whether any covariation between growth traits and relative telomere length depends on the social environment, as influenced by sibling sex ratio. Relative telomere length declined on average over the period of nestling maximal growth rate (between 7 and 16 days of age and differently covaried with initial relative telomere length in either sex. The frequency distribution of changes in relative telomere length was bimodal, with most nestlings decreasing and some increasing relative telomere length, but none of the offspring traits predicted the a posteriori identified group to which individual nestlings belonged. Tail and wing length increased with relative telomere length, but more steeply in males than females, and this relationship held both at the within- and among-broods levels. Moreover, the increase in plumage phenotypic values was steeper when the sex ratio of an individual's siblings was female-biased. Our study provides evidence for telomere shortening during early life according to subtly different dynamics in either sex. Furthermore, it shows that the positive covariation between growth and

  7. Effect of Irrigation with Contaminated Water by Cloth Detergent on Seed Germination Traits and Early Growth of Sunflower (Helianthus annuus L.

    Directory of Open Access Journals (Sweden)

    Hassan HEIDARI

    2013-02-01

    Full Text Available One of the sources for irrigation is sewage. Contaminated water may affect seed germination and plant growth. A laboratory experiment and a pot experiment were conducted in 2012 to determine the effect of different doses of detergent on seed germination traits and early growth of sunflower (Helianthus annuus L.. The experiments included eight doses of cloth detergent (0, 0.00002, 0.0002, 0.002, 0.02, 0.2, 2, 20 g/L. Results showed that 20 and 2 g/L of detergent severely reduced seed germination, plant height, leaf number per plant, total biomass and stem weight. 20 g/L of detergent reduced shoot length, root length, seedling weight and seed vigor. Seed germination stage was more sensitive to contaminated water than early growth stage. The results demonstrated that irrigating sunflower by contaminated water with household cleaning products at high concentration should be avoided.

  8. Effects of four dim vs high intensity red color light regimens on growth performance and welfare of broilers

    Directory of Open Access Journals (Sweden)

    D. Senaratna

    2018-01-01

    Full Text Available Objective Broilers show clear preference towards red color light (RL. However setting of an optimum light intensity is difficult since dim intensities that favor growth reduce welfare. This experiment was conducted to test the most effective RL intensity regimen (Dim [5 lux; DI] vs high [320 lux; HI] in combination applied at different growth stages that favors for both performance and welfare. Methods Complete randomize design was adopted with 6 replicates. Treatments were; T1 = early DI (8–21 d+latter HI (22–35 d; T2 = early DI (8–28 d+latter HI (29–35 d, T3 = early HI (8–21 d+latter DI (22–35 d, T4 = early HI (8–28 d+latter DI (29–35 d and T5 = control (white light; WT (8–35 d at medium intensity (20 lux. Body weight (BW, weight gain (WG, water/feed intake and ratio, feed conversion ratios (FCR were assessed. Common behaviours (15 were recorded by scan sampling method. Lameness, foot pad dermatitis, breast blisters, hock burning damage were assessed as welfare parameters. Fear reactions were tested using Tonic Immobility Test. Ocular and carcass evaluations were done. Meat and tibiae were analyzed for fat and bone ash respectively. Results On 35 d, the highest BW (2,155.72±176 g, WG (1,967.78±174 g were recorded by T2 compared to WT (BWWT = 1,878.22±155, WGWT = 1,691.83±160. But, application of RL, either DI, or HI during early/latter stage had no significant effect on FCR. Under HI, birds showed much higher active behaviours. DI encourages eating. Though LI changed from DI to HI, same trend could be seen even under HI. The highest leg strength (218.5±120 s was recorded by T2. The lowest leg strength (64.58±33 s and the highest ocular weight (2.48±1 g were recorded by T1. Significantly (p<0.05 the highest skin weight (162.17±6 g but the lowest fat% in meat (13.03%±5% was recorded by T2. Conclusion Early exposure to DI-RL up to 28 days followed by exposure to HI-RL is the most favorable lighting regimen for

  9. Growth Performance and Initial Heritability Estimates for Growth Traits in Juvenile Sea Urchin Tripneustes gratilla

    Directory of Open Access Journals (Sweden)

    Ma. Josefa Pante

    2007-06-01

    Full Text Available Genetic improvement of performance traits of maricultured species is becoming an important concern. Improvement of performance traits is important for two reasons: it enhances the growth and survival of the animals and it translates to economic gains to the fish farmer. In the sea urchin, Tripneustes gratilla, growth performance of the different families and heritabilities for wet weight, test diameter and test height were estimated from 1,020 offspring from a mating of each of the 15 males with 1 or 2 females. Measurements were done monthly starting at the grow-out stage or four months after hatching. There were significant family differences for the performance traits in sea urchin reared in tanks at the BML hatchery as revealed by ANOVA. Estimates of heritabilities based on the sire component of variance were low for wet weight (0.027, test diameter (0.033 and zero for test height. Heritabilities estimated from the dam component of variance were low for wet weight (0.063, moderate for test diameter (0.286 and test height (0.227. The results indicate that test diameter and wet weight have lowly heritable traits, which means that mass or individual selection may not be the best method for improving the traits for sea urchin populations in Bolinao. Other methods such as family and combined family selection should be explored.

  10. Study on growth performance of Murrah buffaloes raised under farm ...

    African Journals Online (AJOL)

    VCRI_AN_GENETICS

    Non-genetic and genetic factors influencing growth performance in. Murrah ... Central Cattle Breeding Farm, Alamadhi, Tamil Nadu, India, born in the period between 1990 and 2004 were .... and permanent environmental effects due to dam.

  11. Growth performance of crossbred kids (Boer x Indigenous Goat Breeds

    Directory of Open Access Journals (Sweden)

    Tsegay Teklebrhan

    2018-06-01

    Full Text Available The study was conducted to evaluate growth performance of crossbred (Boer x Hararaghe Highland and Boer x Short Eared Somali kids at Haramaya University Goat Farm in Eastern Ethiopia. Breed (p

  12. Effect of Production System on Welfare Traits, Growth Performance ...

    African Journals Online (AJOL)

    Duck feather quality was greater and gait defects were reduced in NRS system compared with FRS and WRS systems. Fluctuating asymmetry (FA) was not affected by the production system. Growth performance was not significantly different between FRS and WRS systems. Average daily weight gain of FRS ducks was ...

  13. Evaluation of Growth Performance of Tomato in Response to ...

    African Journals Online (AJOL)

    Field experiment was conducted in 2013 and 2014 to evaluate growth performance of two tomato genotypes in response to biochar application and arbuscular mycorrhizal fungal (AMF) inoculation at the Teaching and Research Farm, Federal University of Agriculture, Abeokuta. The experiment was laid out in a split-split ...

  14. Study on Biodiesel plants growth performance and tolerance to ...

    African Journals Online (AJOL)

    Abstract. In this research, we studied the growth performance and tolerance of three biodiesel plants namely; Jatropha curcas, Moringa oleifera and Ricinus communis to water stress. Research conducted on the three different soils from Kaita, Jibiya and Mai'adua in the semi-desert environments of Katsina State, Nigeria.

  15. Breeding of early restorer Fuhui 306 and predominant performance of F1 hybrid combinations

    International Nuclear Information System (INIS)

    Wu Wanyi; Liu Yongqiang; Wu Maoli; Xue Xingqiong

    2004-01-01

    Fuhui 306, an early rice restorer with strong restoring ability, short growth period (86 days) and no restriction of separating areas in seed production, was bred by radiation treatment. F 1 hybrid combinations with different mature period were developed when cross with different sterile lines, that combination would be widely applied to meet the requirement of different ecological environment and harvest period. (authors)

  16. Does the association between early life growth and later obesity differ by race/ethnicity or socioeconomic status? A systematic review.

    Science.gov (United States)

    Andrea, Sarah B; Hooker, Elizabeth R; Messer, Lynne C; Tandy, Thomas; Boone-Heinonen, Janne

    2017-09-01

    Rapid growth during infancy predicts higher risk of obesity later in childhood. The association between patterns of early life growth and later obesity may differ by race/ethnicity or socioeconomic status (SES), but prior evidence syntheses do not consider vulnerable subpopulations. We systemically reviewed published studies that explored patterns of early life growth (0-24 months of age) as predictors of later obesity (>24 months) that were either conducted in racial/ethnic minority or low-SES study populations or assessed effect modification of this association by race/ethnicity or SES. Literature searches were conducted in PubMed and SocINDEX. Ten studies met the inclusion criteria. Faster growth during the first 2 years of life was consistently associated with later obesity irrespective of definition and timing of exposure and outcome measures. Associations were strongest in populations composed of greater proportions of racial/ethnic minority and/or low-SES children. For example, ORs ranged from 1.17 (95% CI: 1.11, 1.24) in a heterogeneous population to 9.24 (95% CI: 3.73, 22.9) in an entirely low-SES nonwhite population. The impact of rapid growth in infancy on later obesity may differ by social stratification factors such as race/ethnicity and family income. More robust and inclusive studies examining these associations are needed. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial.

    Science.gov (United States)

    Iannotti, Lora L; Lutter, Chessa K; Stewart, Christine P; Gallegos Riofrío, Carlos Andres; Malo, Carla; Reinhart, Gregory; Palacios, Ana; Karp, Celia; Chapnick, Melissa; Cox, Katherine; Waters, William F

    2017-07-01

    Eggs are a good source of nutrients for growth and development. We hypothesized that introducing eggs early during complementary feeding would improve child nutrition. A randomized controlled trial was conducted in Cotopaxi Province, Ecuador, from March to December 2015. Children ages 6 to 9 months were randomly assigned to treatment (1 egg per day for 6 months [ n = 83]) and control (no intervention [ n = 80]) groups. Both arms received social marketing messages to encourage participation in the Lulun Project ( lulun meaning "egg" in Kichwa). All households were visited once per week to monitor morbidity symptoms, distribute eggs, and monitor egg intakes (for egg group only). Baseline and end point outcome measures included anthropometry, dietary intake frequencies, and morbidity symptoms. Mothers or other caregivers reported no allergic reactions to the eggs. Generalized linear regression modeling showed the egg intervention increased length-for-age z score by 0.63 (95% confidence interval [CI], 0.38-0.88) and weight-for-age z score by 0.61 (95% CI, 0.45-0.77). Log-binomial models with robust Poisson indicated a reduced prevalence of stunting by 47% (prevalence ratio [PR], 0.53; 95% CI, 0.37-0.77) and underweight by 74% (PR, 0.26; 95% CI, 0.10-0.70). Children in the treatment group had higher dietary intakes of eggs (PR, 1.57; 95% CI, 1.28-1.92) and reduced intake of sugar-sweetened foods (PR, 0.71; 95% CI, 0.51-0.97) compared with control. The findings supported our hypothesis that early introduction of eggs significantly improved growth in young children. Generally accessible to vulnerable groups, eggs have the potential to contribute to global targets to reduce stunting. Copyright © 2017 by the American Academy of Pediatrics.

  18. The Proteomic Signature of Aspergillus fumigatus During Early Development*

    Science.gov (United States)

    Cagas, Steven E.; Jain, Mohit Raja; Li, Hong; Perlin, David S.

    2011-01-01

    Aspergillus fumigatus is a saprophytic fungus that causes a range of diseases in humans including invasive aspergillosis. All forms of disease begin with the inhalation of conidia, which germinate and develop. Four stages of early development were evaluated using the gel free system of isobaric tagging for relative and absolute quantitation to determine the full proteomic profile of the pathogen. A total of 461 proteins were identified at 0, 4, 8, and 16 h and fold changes for each were established. Ten proteins including the hydrophobin rodlet protein RodA and a protein involved in melanin synthesis Abr2 were found to decrease relative to conidia. To generate a more comprehensive view of early development, a whole genome microarray analysis was performed comparing conidia to 8 and 16 h of growth. A total of 1871 genes were found to change significantly at 8 h with 1001 genes up-regulated and 870 down-regulated. At 16 h, 1235 genes changed significantly with 855 up-regulated and 380 down-regulated. When a comparison between the proteomics and microarray data was performed at 8 h, a total of 22 proteins with significant changes also had corresponding genes that changed significantly. When the same comparison was performed at 16 h, 12 protein and gene combinations were found. This study, the most comprehensive to date, provides insights into early pathways activated during growth and development of A. fumigatus. It reveals a pathogen that is gearing up for rapid growth by building translation machinery, generating ATP, and is very much committed to aerobic metabolism. PMID:21825280

  19. Newborn length predicts early infant linear growth retardation and disproportionately high weight gain in a low-income population.

    Science.gov (United States)

    Berngard, Samuel Clark; Berngard, Jennifer Bishop; Krebs, Nancy F; Garcés, Ana; Miller, Leland V; Westcott, Jamie; Wright, Linda L; Kindem, Mark; Hambidge, K Michael

    2013-12-01

    Stunting is prevalent by the age of 6 months in the indigenous population of the Western Highlands of Guatemala. The objective of this study was to determine the time course and predictors of linear growth failure and weight-for-age in early infancy. One hundred and forty eight term newborns had measurements of length and weight in their homes, repeated at 3 and 6 months. Maternal measurements were also obtained. Mean ± SD length-for-age Z-score (LAZ) declined from newborn -1.0 ± 1.01 to -2.20 ± 1.05 and -2.26 ± 1.01 at 3 and 6 months respectively. Stunting rates for newborn, 3 and 6 months were 47%, 53% and 56% respectively. A multiple regression model (R(2) = 0.64) demonstrated that the major predictor of LAZ at 3 months was newborn LAZ with the other predictors being newborn weight-for-age Z-score (WAZ), gender and maternal education∗maternal age interaction. Because WAZ remained essentially constant and LAZ declined during the same period, weight-for-length Z-score (WLZ) increased from -0.44 to +1.28 from birth to 3 months. The more severe the linear growth failure, the greater WAZ was in proportion to the LAZ. The primary conclusion is that impaired fetal linear growth is the major predictor of early infant linear growth failure indicating that prevention needs to start with maternal interventions. © 2013.

  20. Early anthropometric indices predict short stature and overweight status in a cohort of Peruvians in early adolescence

    Science.gov (United States)

    Sterling, Robie; Miranda, J Jaime; Gilman, Robert H; Cabrera, Lilia; Sterling, Charles R; Bern, Caryn; Checkley, William

    2014-01-01

    While childhood malnutrition is associated with increased morbidity and mortality, less well understood is how early childhood growth influences height and body composition later in life. We revisited 152 Peruvian children who participated in a birth cohort study between 1995 and 1998, and obtained anthropometric and bioimpedance measurements 11 to 14 years later. We used multivariable regression models to study the effects of childhood anthropometric indices on height and body composition in early adolescence. Each standard deviation decrease in length-for-age at birth was associated with a decrease in adolescent height-for-age of 0.7 SD in both boys and girls (all poverweight in early adolescence. Linear growth retardation in early childhood is a strong determinant of adolescent stature, indicating that, in developing countries, growth failure in height during early childhood persists through early adolescence. Interventions addressing linear growth retardation in childhood are likely to improve adolescent stature and related-health outcomes in adulthood. PMID:22552904

  1. Feed utilization and growth performance of cockerels fed with ...

    African Journals Online (AJOL)

    The study was conducted to evaluate the effects of soldier ant as dietary supplements on the growth performance of cockerels. Two hundred cockerels of Nera white strain (aged 6 weeks) were randomly assigned into 5 dietary treatments in a completely randomized design. Each treatment was replicated 5 times with 8 ...

  2. Growth performance and nutrient digestibility of broiler chickens fed ...

    African Journals Online (AJOL)

    Two hundred and seventy (270), day old chicks were used in a completely randomized design experimental layout to test the growth performance and nutrient digestibility of broiler chickens fed single phase diets containing natuzyme™ treated groundnut shell at 0, 5, 10, 15, 20 and 25 % inclusion levels. The treatments ...

  3. Estimation of the growth curve and heritability of the growth rate for giant panda (Ailuropoda melanoleuca) cubs.

    Science.gov (United States)

    Che, T D; Wang, C D; Jin, L; Wei, M; Wu, K; Zhang, Y H; Zhang, H M; Li, D S

    2015-03-27

    Giant panda cubs have a low survival rate during the newborn and early growth stages. However, the growth and developmental parameters of giant panda cubs during the early lactation stage (from birth to 6 months) are not well known. We examined the growth and development of giant panda cubs by the Chapman growth curve model and estimated the heritability of the maximum growth rate at the early lactation stage. We found that 83 giant panda cubs reached their maximum growth rate at approximately 75-120 days after birth. The body weight of cubs at 75 days was 4285.99 g. Furthermore, we estimated that the heritability of the maximum growth rate was moderate (h(2) = 0.38). Our study describes the growth and development of giant panda cubs at the early lactation stage and provides valuable growth benchmarks. We anticipate that our results will be a starting point for more detailed research on increasing the survival rate of giant panda cubs. Feeding programs for giant panda cubs need further improvement.

  4. Early Onset Intrauterine Growth Restriction in a Mouse Model of Gestational Hypercholesterolemia and Atherosclerosis

    Science.gov (United States)

    Busso, Dolores; Mascareño, Lilian; Salas, Francisca; Berkowitz, Loni; Santander, Nicolás; Quiroz, Alonso; Amigo, Ludwig; Valdés, Gloria; Rigotti, Attilio

    2014-01-01

    The susceptibility to develop atherosclerosis is increased by intrauterine growth restriction and prenatal exposure to maternal hypercholesterolemia. Here, we studied whether mouse gestational hypercholesterolemia and atherosclerosis affected fetal development and growth at different stages of gestation. Female LDLR KO mice fed a proatherogenic, high cholesterol (HC) diet for 3 weeks before conception and during pregnancy exhibited a significant increase in non-HDL cholesterol and developed atherosclerosis. At embryonic days 12.5 (E12.5), E15.5, and E18.5, maternal gestational hypercholesterolemia and atherosclerosis were associated to a 22–24% reduction in male and female fetal weight without alterations in fetal number/litter or morphology nor placental weight or structure. Feeding the HC diet exclusively at the periconceptional period did not alter fetal growth, suggesting that maternal hypercholesterolemia affected fetal weight only after implantation. Vitamin E supplementation (1,000 UI of α-tocopherol/kg) of HC-fed females did not change the mean weight of E18.5 fetuses but reduced the percentage of fetuses exhibiting body weights below the 10th percentile of weight (HC: 90% vs. HC/VitE: 68%). In conclusion, our results showed that maternal gestational hypercholesterolemia and atherosclerosis in mice were associated to early onset fetal growth restriction and that dietary vitamin E supplementation had a beneficial impact on this condition. PMID:25295255

  5. Catch-up growth in early treated patients with growth hormone deficiency. Dutch Growth Hormone Working Group.

    OpenAIRE

    Boersma, B; Rikken, B; Wit, J M

    1995-01-01

    Catch-up growth of 26 children with growth hormone deficiency during four years of growth hormone treatment, which was started young (< 3 years), was compared with that of 16 children with coeliac disease on a gluten free diet. In children with growth hormone deficiency mean (SD) height SD score increased from -4.3 (1.8) to -1.9 (1.4) and in patients with coeliac disease from -1.8 (0.9) to -0.1 (0.8). Height SD score after four years correlated positively with injection frequency and height S...

  6. Effect of days in feedlot on growth performance and carcass ...

    African Journals Online (AJOL)

    Effect of days in feedlot on growth performance and carcass characteristics of Merino, South African Mutton Merino and Dorper lambs. T.S. Brand, E.J. van der Westhuizen, D.A. van der Merwe, L.C. Hoffman ...

  7. Fetal, neonatal, infant, and child international growth standards: an unprecedented opportunity for an integrated approach to assess growth and development.

    Science.gov (United States)

    Garza, Cutberto

    2015-07-01

    The recent publication of fetal growth and gestational age-specific growth standards by the International Fetal and Newborn Growth Consortium for the 21st Century Project and the previous publication by the WHO of infant and young child growth standards based on the WHO Multicentre Growth Reference Study enable evaluations of growth from ∼9 wk gestation to 5 y. The most important features of these projects are the prescriptive approach used for subject selection and the rigorous testing of the assertion that growth is very similar among geographically and ethnically diverse nonisolated populations when health, nutrition, and other care needs are met and the environment imposes minimal constraints on growth. Both studies documented that with adequate controls, the principal source of variability in growth during gestation and early childhood resides among individuals. Study sites contributed much less to observed variability. The agreement between anthropometric measurements common to both studies also is noteworthy. Jointly, these studies provide for the first time, to my knowledge, a conceptually consistent basis for worldwide and localized assessments and comparisons of growth performance in early life. This is an important contribution to improving the health care of children across key periods of growth and development, especially given the appropriate interest in pursuing "optimal" health in the "first 1000 d," i.e., the period covering fertilization/implantation, gestation, and postnatal life to 2 y of age. © 2015 American Society for Nutrition.

  8. Performance Measurements, Critical Facts to Business Growth – Exemplification on Automotive Industry

    Directory of Open Access Journals (Sweden)

    Andreea Ileana ZAMFIR

    2012-12-01

    Full Text Available An important consideration in the process of modeling business processes is that in order to improve, you must define the current state of work. Accordingly, the general argument for business growth based on performance measurement is that in order to improve the process in the future, you must know how activities are conducted in the present. The article presents the key elements of performance measurements in relation to business growth, taking also into account main challenges and obstacles. The author based the research upon a larger study of increasing performance, developed inside four companies from an extended supply chain in automotive industry, relating the theoretical discoveries in the field with the real business experience.

  9. Delayed match-to-sample early performance decrement in monkeys after 60Co irradiation

    International Nuclear Information System (INIS)

    Bruner, A.; Bogo, V.; Jones, R.K.

    1975-01-01

    Sixteen monkeys were trained on a delayed match-to-sample task (DMTS) based on shock avoidance and irradiated with single, whole-body exposures of from 396 to 2000 rad 60 Co (midbody dose) at between 163 and 233 rad/min. Pre- to post-irradiation performance changes were assessed using a penalty-scaling measure which differentially weighted incorrect responses, response omissions, and error-omission sequences. Thirteen of the animals displayed early performance decrement, including five incapacitations, at lower doses (less than 1000 rad) than heretofore found effective. This was considered a function of task complexity, measurement sensitivity, and gamma effectiveness. The minimum effective midbody dose for inducing decrement using the DMTS task was estimated to be on the order of 500 rad. The nature of early, transient performance decrement seems to reflect more of an inability to perform than an inability to perform correctly

  10. The Influence of Early Protein Energy Malnutrition on Subsequent Behavior and Intellectual Performance.

    Science.gov (United States)

    Gupta, Sarita

    1990-01-01

    Protein-energy malnutrition in early childhood, as seen in many developing countries, influences subsequent behavior and intellectual performance. These impairments are associated with further reduction in fine motor skills and academic performance. (Author)

  11. Rapid growth in early childhood associated with young adult overweight and obesity--evidence from a community based cohort study.

    Science.gov (United States)

    Sutharsan, Ratneswary; O'Callaghan, Michael J; Williams, Gail; Najman, Jake M; Mamun, Abdullah A

    2015-08-08

    Rapid weight gain in early life may increase the risk of overweight and obesity in adulthood. We investigated the association between the rate of growth during early childhood and the development of overweight and obesity in young adults. We used a prospective cohort study of 2077 young adults who were born between 1981 and 1984 in Brisbane, Australia and had anthropometry measurements available at birth, 6 months, 5 years, 14 years and 21 years of age. The associations of rate of early growth with body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) and their categories at 21 years were studied using multivariate analysis. We found that rapid weight gain [> + 0.67 standard deviation score (SDS)] in the first 5 years of life was associated with young adults' overweight status (BMI: adjusted OR = 2.35, 95% CI, 1.82-3.03; WC: adjusted OR = 2.20, 95% CI, 1.65-2.95). We also observed that slow weight gain in the first 5 years of age (young adulthood, in contrast slow weight gain was inversely associated with weight status at 21 years.

  12. Effect of chicken genotype on growth performance and feed ...

    African Journals Online (AJOL)

    This experiment was conducted to assess the effect of chicken genotype on the growth performance, feed intake and feed efficiency of the progenies resulting from pure, straight and reciprocal cross of Giriraja (Gr) and Alpha chickens. Data obtained on body weight, body length, breast girth, keel length, feed intake and feed ...

  13. Growth performance and immunity status of starter broiler birds ...

    African Journals Online (AJOL)

    This study was conducted to investigate the effects of feeding diets containing Neem Leaf Meal (NLM), Garlic Meal (GM) and their combinations (NLM + GM) on growth performance and serum parameters of starter broiler birds. A total of 180 day-old Cobb broiler chickens were divided into twelve groups of fifteen chicks with ...

  14. Evaluating growth performance of young stands

    Science.gov (United States)

    A. L. Roe; R. E. Benson

    1966-01-01

    A simple procedure for evaluating the diameter growth of young stands in relation to potential growth is described. A comparison technique is developed which contrasts relative diameter of crop trees to the relative diameter growth of the last decade to show the condition and trend of growth in the stand. The method is objective, easy to use, and has several...

  15. The early growth and development study: a prospective adoption design.

    Science.gov (United States)

    Leve, Leslie D; Neiderhiser, Jenae M; Ge, Xiaojia; Scaramella, Laura V; Conger, Rand D; Reid, John B; Shaw, Daniel S; Reiss, David

    2007-02-01

    The Early Growth and Development Study is a prospective adoption study of birth parents, adoptive parents, and adopted children (N=359 triads) that was initiated in 2003. The primary study aims are to examine how family processes mediate or moderate the expression of genetic influences in order to aid in the identification of specific family processes that could serve as malleable targets for intervention. Participants in the study are recruited through adoption agencies located throughout the United States, following the birth of a child. Assessments occur at 6-month intervals until the child reaches 3 years of age. Data collection includes the following primary constructs: infant and toddler temperament, social behavior, and health; birth and adoptive parent personality characteristics, psychopathology, competence, stress, and substance use; adoptive parenting and marital relations; and prenatal exposure to drugs and maternal stress. Preliminary analyses suggest the representativeness of the sample and minimal confounding effects of current trends in adoption practices, including openness and selective placement. Future plans are described.

  16. Does Early Kurmanji Speaking Bilingualism Lead to Better Academic Performance? The Role of Working Memory and Reading Performance

    Science.gov (United States)

    Seadatee-Shamir, Abootaleb; Soleimanian, AliAkbar; Zahmatkesh, Zeinab; Mahdian, Hossein

    2011-01-01

    The relationship among WMC (working memory capacity), reading performance and academic achievement is both logically and theoretically undisputable. However, what may not be as obvious is that such capacity and performance, and as a result, achievement, could be higher among ECBL (early childhood bilingual) students. To reaffirm the obvious and…

  17. Growth performance and economy of production of grower pigs fed ...

    African Journals Online (AJOL)

    meal-based diets. ... International Journal of Tropical Agriculture and Food Systems ... Twenty-four landrace x large white grower pigs were used to study the effect of maize-cob- meal-based diets on the growth performance and economy of ...

  18. Interannual differences in growth and hatch-date distributions of early juvenile European anchovy in the Bay of Biscay: implications for recruitment

    KAUST Repository

    Aldanondo, Naroa

    2016-01-22

    © 2016 John Wiley & Sons Ltd. In order to understand better the recruitment variability in European anchovy in the Bay of Biscay, it is important to investigate the processes that affect survival during the early life stages. Anchovy juvenile growth trajectories and hatch-date distributions were inferred over a 3-year period based on otolith microstructure analysis. Otolith growth trajectories showed a characteristic shape depending on their hatch-date timing. Earlier-born juveniles had notably broader maximum increments than later born conspecifics, resulting in higher growth rates. This observation suggests that early hatching would be beneficial for larval and juvenile growth, and, therefore, survival. The estimated juvenile hatch-date distributions were relatively narrow compared with the extended anchovy spawning season (March-August) in the Bay of Biscay and indicated that only individuals originated mainly from the summer months (June-August) survived until autumn. Hatch-date distributions were markedly different among years and seemed to influence the interannual recruitment strength of anchovy. We conclude that years characterized by juvenile survivors originating from the peak spawning period (May and June) would lead to considerable recruitment success. Downwelling events during the peak spawning period seem to affect larval survival.

  19. Early Observations on the Performance of Windows Azure

    Directory of Open Access Journals (Sweden)

    Zach Hill

    2011-01-01

    Full Text Available A significant open issue in cloud computing is the real performance of the infrastructure. Few, if any, cloud providers or technologies offer quantitative performance guarantees. Regardless of the potential advantages of the cloud in comparison to enterprise-deployed applications, cloud infrastructures may ultimately fail if deployed applications cannot predictably meet behavioral requirements. In this paper, we present the results of comprehensive performance experiments we conducted on Windows Azure from October 2009 to February 2010. In general, we have observed good performance of the Windows Azure mechanisms, although the average 10 min VM startup time must be accounted for in application design. We also present performance and reliability observations and analysis from our deployment of a large-scale scientific application hosted on Azure, called ModisAzure, that show unusual and sporadic VM execution slowdown of over 4× in some cases and affected up to 16% of task executions at times. In addition to a detailed performance evaluation of Windows Azure, we provide recommendations for potential users of Windows Azure based on these early observations. Although the discussion and analysis is tailored to scientific applications, the results are broadly applicable to the range of existing and future applications running in Windows Azure.

  20. Assessing the early degradation of photovoltaic modules performance in the Saharan region

    International Nuclear Information System (INIS)

    Kahoul, Nabil; Houabes, Mourad; Sadok, Mohammed

    2014-01-01

    Highlights: • The study underlines the reliability of PV modules in South Algeria. • Early degradation of PV modules operating in the Saharan region for 11 years. • Performance analysis of these PV panels with suitable explanation of results. • Discovery of early degradation of PV modules performance and some PV defects. - Abstract: In this study, the electrical performance degradation of photovoltaic modules (UDTS-50) functioning for a period of 11 years in a region of the Sahara (URER-MS ADRAR) is analyzed. This paper is devoted to an experimental study of current–voltage characteristics of several PV modules exposed to the extreme weather conditions in desert area. The electrical performance degradation and failure modes are estimated from series of current–voltage characteristics performed in the field. Experimental results show that some PV modules degrade up to 12% compared to their initial state. The performance analysis of the others tested modules revealed some defects, such as cracked cells and physical material defects. The identification of the origin of degradation and failure modes and how they affect the photovoltaic modules is necessary to improve the reliability of photovoltaic installations

  1. Early dietary treated patients with phenylketonuria can achieve normal growth and body composition.

    Science.gov (United States)

    Rocha, Júlio C; van Spronsen, Francjan J; Almeida, Manuela F; Ramos, Elisabete; Guimarães, João T; Borges, Nuno

    2013-01-01

    In the past, overtreatment may have resulted in growth impairment in patients with phenylketonuria. The paper aims to investigate height and body composition in early treated patients with phenylketonuria who were diagnosed between 1981 and 2008. A cross-sectional study of 89 patients with phenylketonuria and 78 controls aged (mean ± SD, in years) 14.4 ± 6.6 and 15.9 ± 7.1, respectively, was undertaken, including anthropometric and body composition evaluation using bioelectrical impedance. Median Phe concentrations in the last year before study enrollment were used as a measure of metabolic control. Natural protein and amino acid mixture intakes were recorded in patients. No statistically significant differences were found on height z-scores between patients and controls aged less than 19 years (p=0.301), although all patients with classical phenylketonuria revealed negative height z-scores, resulting in a mean ± SD of -0.65 ± 0.41. Among participants aged 19 years or more, median (p25-p75) of height was significantly higher in controls [168.0 cm (159.2-174.8)] than in patients [160.5 cm (151.9-167.5)] (p=0.017). No significant differences were found between patients and controls regarding fat mass, fat free mass, muscular mass, body cell mass index and phase angle. Our results suggest that early and continuously treated patients with phenylketonuria born after 1992 can achieve normal growth and body composition, although the negative height z-score in patients with classical phenylketonuria strengthens the continuous need to optimize the quality of their protein intake. © 2013 Elsevier Inc. All rights reserved.

  2. Association between the high soluble fms-like tyrosine kinase-1 to placental growth factor ratio and adverse outcomes in asymptomatic women with early-onset fetal growth restriction.

    Science.gov (United States)

    Shinohara, Satoshi; Uchida, Yuzo; Kasai, Mayuko; Sunami, Rei

    2017-08-01

    To assess whether the high soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is associated with adverse outcomes (e.g., HELLP syndrome [hemolysis, elevated liver enzymes, and low platelets], severe hypertension uncontrolled by medication, non-reassuring fetal status, placental abruption, pulmonary edema, growth arrest, maternal death, or fetal death) and a shorter duration to delivery in early-onset fetal growth restriction (FGR). Thirty-four women with FGR diagnosed at Women who developed adverse outcomes within a week had a significantly higher sFlt-1/PlGF ratio than did those who did not develop complications. A cutoff value of 86.2 for the sFlt-1/PlGF ratio predicted adverse outcomes, with a sensitivity and specificity of 77.8% and 80.0%, respectively. Moreover, 58.4% of women with an sFlt-1/PlGF ratio ≥86.2 versus 9.1% of those with an sFlt-1/PlGF ratio <86.2 delivered within a week of presentation (p < 0.001). In multivariate analyses, an sFlt-1/PlGF ratio ≥86.2 (adjusted odds ratio 9.52; 95% confidence interval, 1.25-72.8) was associated with adverse maternal and neonatal outcomes. A high sFlt-1/PlGF ratio was associated with adverse outcomes and a shorter duration to delivery in early-onset FGR.

  3. Early wide spacing in red alder (Alnus rubra Bong.): effects on stem form and stem growth.

    Science.gov (United States)

    Bernard T. Bormann

    1985-01-01

    A thinning trial was established in 1962 in a 7-year-old red alder stand in northwestern Washington. Spacings were 8 x 8 ft (dense), 12 x 12 it (intermediate), and 16 x 16 ft (open). The effect of early thinning on growth and stem form was measured in 1982, 20 years after spacing treatment. There was negligible tree lean and sweep in open and intermediate stands except...

  4. In-Vision Continuity Announcers: Performing an Identity for Early Television in Europe

    Directory of Open Access Journals (Sweden)

    Sonja de Leeuw

    2013-12-01

    Full Text Available In-vision continuity announcers have played central – yet understudied – roles in early television history. Through their performances on and off the screen, they mediated the identity of the televisual medium in the 1950s and 1960s, popularizing it as a medium of sound and vision, a domestic and gendered medium as well as a national and transnational institution.Focusing primarily on Dutch and Romanian female in-vision continuity announcers in the 1950s and 60s and making extensive comparisons with other countries in Europe, this article illustrates how these early professionals of television performed as part of a European-wide phenomenon of defining the identity of the new televisual medium.

  5. Growth performance and feed utilization of Tilapia zillii (Gervais ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-07-06

    Jul 6, 2009 ... Accepted 22 May, 2009. The aim of this study was to investigate the growth performance, feed utilization and body composition of Tilapia zillii fed diets where poultry by-product meal replaced fish meal protein at 0, 50 and 100% ... fish diets because of its high protein quality and palata- bility. However, fish ...

  6. Effect of sage extract ( Salvia officinalis ) on growth performance ...

    African Journals Online (AJOL)

    This study was performed to evaluate the effect of different doses of sage extract on the growth and blood parameters, oxidative stress and DNA damage in partridges. In total, 252 day-old partridges (Alectoris chukar) were used. The birds were divided into four groups: 0.1% flavomycin was included in the diet of the control ...

  7. Coping with a changing environment: The effects of early life stress

    DEFF Research Database (Denmark)

    Vindas, Marco A.; Madaro, Angelico; Fraser, Thomas W.K.

    2016-01-01

    to environmental changes is particularly evident at early life stages. We investigated the performance of salmon, previously subjected to an unpredictable chronic stress (UCS) treatment at an early age (10 month old parr), over several months and life stages. The UCS fish showed overall higher specific growth...... rates compared with unstressed controls after smoltification, a particularly challenging life stage, and after seawater transfer. Furthermore, subjecting fish to acute stress at the end of the experiment, we found that UCS groups had an overall lower hypothalamic catecholaminergic and brain stem...... serotonergic response to stress compared with control groups. In addition, serotonergic activity was negatively correlated with final growth rates,which implies that serotonin responsive individuals have growth disadvantages. Altogether, our results may imply that a subduedmonoaminergic response in stressful...

  8. Dentoalveolar growth of patients with complete unilateral cleft lip and palate by early two-stage furlow and push-back method: preliminary results.

    Science.gov (United States)

    Kitagawa, Taiji; Kohara, Hiroshi; Sohmura, Taiji; Takahashi, Junzo; Tachimura, Takashi; Wada, Takeshi; Kogo, Mikihiko

    2004-09-01

    This study examined dentoalveolar growth changes prior to the time of palatoplasty up to 3 years of age by the early two-stage Furlow and push-back methods. Thirty-four Japanese patients with complete unilateral cleft lip and palate (UCLP) treated with either a two-stage Furlow procedure (Furlow group: seven boys, eight girls) from 1998 to 2002 or a push-back procedure (push-back group; 12 boys, 7 girls) from 1993 to 1997. Consecutive plaster models were measured by three-dimensional laser scanner, before primary palatoplasty, before hard palate closure (Furlow group only), and at 3 years of age. Bite measures were taken at 3 years of age. In the Furlow group, arch length, canine width, first and second deciduous molar width and cross-sectional area, and depth and volume at midpoint showed greater growth than in the push-back group. In the Furlow group, the crossbite score was also better than in the push-back group at 3 years of age. In comparison with the push-back group, inhibition of growth impediment in the anterior region was observed in the horizontal direction in the Furlow group. In the midregion, it was observed in the horizontal and vertical directions, and in the posterior region it was observed in the horizontal direction. The results demonstrate that the early two-stage Furlow method showed progressive alveolar growth. Therefore, the early two-stage Furlow method is a more beneficial procedure than the push-back method.

  9. Empirical testing of Kotler's high-performance factors to increase sales growth

    Directory of Open Access Journals (Sweden)

    Oren Dayan

    2010-12-01

    Full Text Available Purpose and/or objectives: The primary objective of this study is to empirically test Kotler's (2003 high-performance model which ensures an increase in sales growth. More specifically, the study explores the influence of process variables (as measured by marketing strategies, resources management (as measured by the management of labour, materials, machines, information technology and energy and organisational variables (as measured by TQM and organisational culture on sales growth in the food, motorcar and high-technology manufacturing industries. Problem investigated Various research studies suggest that the managers of firms are continuously challenged in their attempts to increase their sales (Morre, 2007; Pauwels, Silva Risso, Srinivasan & Hanssens, 2004: 142-143; Gray & Hayes, 2007: 1. Kotler (2003 suggests a model that leads to a high performing business. The question is posed as to whether this model can be used to increase sales growth in all businesses. This study seeks to develop a generic model to increase sales growth across industries by using an adapted version of Kotler's (2003 high-performance model. The study investigates the application of this adapted model on the food, motorcar and high-technology manufacturing industries. Design and/or methodology and/or approach: An empirical causal research design that includes 770 marketing and product development practitioners from multinational food, motorcar and high-technology manufacturing firms, was used in this study. A response rate of 76.1% was achieved as only 571 useable questionnaires were returned. The internal reliability and discriminant validity of the measuring instrument were assessed by the calculation of Cronbach alpha coefficients and the conducting an exploratory factor analysis respectively. Structural Equation Modelling SEM was used to statistically test the relationships between the independent variables (marketing strategies, resource management, TQM and

  10. Rapid growth of seed black holes in the early universe by supra-exponential accretion.

    Science.gov (United States)

    Alexander, Tal; Natarajan, Priyamvada

    2014-09-12

    Mass accretion by black holes (BHs) is typically capped at the Eddington rate, when radiation's push balances gravity's pull. However, even exponential growth at the Eddington-limited e-folding time t(E) ~ few × 0.01 billion years is too slow to grow stellar-mass BH seeds into the supermassive luminous quasars that are observed when the universe is 1 billion years old. We propose a dynamical mechanism that can trigger supra-exponential accretion in the early universe, when a BH seed is bound in a star cluster fed by the ubiquitous dense cold gas flows. The high gas opacity traps the accretion radiation, while the low-mass BH's random motions suppress the formation of a slowly draining accretion disk. Supra-exponential growth can thus explain the puzzling emergence of supermassive BHs that power luminous quasars so soon after the Big Bang. Copyright © 2014, American Association for the Advancement of Science.

  11. The need for data science in epidemic modelling. Comment on: "Mathematical models to characterize early epidemic growth: A review" by Gerardo Chowell et al.

    Science.gov (United States)

    Danon, Leon; Brooks-Pollock, Ellen

    2016-09-01

    In their review, Chowell et al. consider the ability of mathematical models to predict early epidemic growth [1]. In particular, they question the central prediction of classical differential equation models that the number of cases grows exponentially during the early stages of an epidemic. Using examples including HIV and Ebola, they argue that classical models fail to capture key qualitative features of early growth and describe a selection of models that do capture non-exponential epidemic growth. An implication of this failure is that predictions may be inaccurate and unusable, highlighting the need for care when embarking upon modelling using classical methodology. There remains a lack of understanding of the mechanisms driving many observed epidemic patterns; we argue that data science should form a fundamental component of epidemic modelling, providing a rigorous methodology for data-driven approaches, rather than trying to enforce established frameworks. The need for refinement of classical models provides a strong argument for the use of data science, to identify qualitative characteristics and pinpoint the mechanisms responsible for the observed epidemic patterns.

  12. Examination of the Pattern of Growth of Cerebral Tissue Volumes From Hospital Discharge to Early Childhood in Very Preterm Infants.

    Science.gov (United States)

    Monson, Brian B; Anderson, Peter J; Matthews, Lillian G; Neil, Jeffrey J; Kapur, Kush; Cheong, Jeanie L Y; Doyle, Lex W; Thompson, Deanne K; Inder, Terrie E

    2016-08-01

    Smaller cerebral volumes at hospital discharge in very preterm (VPT) infants are associated with poor neurobehavioral outcomes. Brain growth from the newborn period to middle childhood has not been explored because longitudinal data have been lacking. To examine the pattern of growth of cerebral tissue volumes from hospital discharge to childhood in VPT infants and to determine perinatal risk factors for impaired brain growth and associations with neurobehavioral outcomes at 7 years. Prospective cohort study of VPT infants (childhood and outcomes in VPT infants. Low brain volumes observed in VPT infants are exaggerated at 7 years. Low brain volume in infancy is associated with long-term functional outcomes, emphasizing the persisting influence of early brain development on subsequent growth and outcomes.

  13. Dietary Lactobacillus plantarum supplementation enhances growth performance and alleviates aluminum toxicity in tilapia.

    Science.gov (United States)

    Yu, Leilei; Zhai, Qixiao; Zhu, Jiamin; Zhang, Chengcheng; Li, Tianqi; Liu, Xiaoming; Zhao, Jianxin; Zhang, Hao; Tian, Fengwei; Chen, Wei

    2017-09-01

    We investigated the protection offered by the probiotic Lactobacillus plantarum CCFM639 against waterborne Al exposure in tilapia. Fish were allocated to control, CCFM639-only, Al-only or Al plus CCFM639 groups. The fish were exposed to 2.73mg/L Al ions for 4 weeks. The probiotic was incorporated into the fish diet at 10 8 CFU/g and provided twice daily. Our results showed that L. plantarum CCFM639 significantly enhanced feed utilization, growth performance and antioxidant ability in the absence of waterborne Al exposure. When fish were exposed to Al, dietary supplementation with the strain effectively decreased the death rate and accumulation of Al in tissues, and enhanced growth performance. Moreover, Al-induced changes in hematobiochemical parameters and hepatic oxidative stress and histopathology were also alleviated. Therefore, L. plantarum CCFM639 may be a novel dietary supplement for fish to enhance growth performance and prevent aquaculture and food safety problems induced by Al pollution. Copyright © 2017. Published by Elsevier Inc.

  14. Cell wall structures leading to cultivar differences in softening rates develop early during apple (Malus x domestica) fruit growth.

    Science.gov (United States)

    Ng, Jovyn K T; Schröder, Roswitha; Sutherland, Paul W; Hallett, Ian C; Hall, Miriam I; Prakash, Roneel; Smith, Bronwen G; Melton, Laurence D; Johnston, Jason W

    2013-11-19

    There is a paucity of information regarding development of fruit tissue microstructure and changes in the cell walls during fruit growth, and how these developmental processes differ between cultivars with contrasting softening behaviour. In this study we compare two apple cultivars that show different softening rates during fruit development and ripening. We investigate whether these different softening behaviours manifest themselves late during ethylene-induced softening in the ripening phase, or early during fruit expansion and maturation. 'Scifresh' (slow softening) and 'Royal Gala' (rapid softening) apples show differences in cortical microstructure and cell adhesion as early as the cell expansion phase. 'Scifresh' apples showed reduced loss of firmness and greater dry matter accumulation compared with 'Royal Gala' during early fruit development, suggesting differences in resource allocation that influence tissue structural properties. Tricellular junctions in 'Scifresh' were rich in highly-esterified pectin, contributing to stronger cell adhesion and an increased resistance to the development of large airspaces during cell expansion. Consequently, mature fruit of 'Scifresh' showed larger, more angular shaped cells than 'Royal Gala', with less airspaces and denser tissue. Stronger cell adhesion in ripe 'Scifresh' resulted in tissue fracture by cell rupture rather than by cell-to-cell-separation as seen in 'Royal Gala'. CDTA-soluble pectin differed in both cultivars during development, implicating its involvement in cell adhesion. Low pectin methylesterase activity during early stages of fruit development coupled with the lack of immuno-detectable PG was associated with increased cell adhesion in 'Scifresh'. Our results indicate that cell wall structures leading to differences in softening rates of apple fruit develop early during fruit growth and well before the induction of the ripening process.

  15. Effect of feeding rate and ammonia build-up on growth performance ...

    African Journals Online (AJOL)

    -up on growth performance of Clarias gariepinus juveniles in the Wet Laboratory, Department of Fisheries and Aquaculture, Ebonyi State University, Abakaliki, Ebonyi State. Completely Randomized Design was used; each treatment was ...

  16. Impact of Witnessing Violence on Growth Curves for Problem Behaviors among Early Adolescents in Urban and Rural Settings

    Science.gov (United States)

    Farrell, Albert D.; Sullivan, Terri N.

    2004-01-01

    Two studies used latent growth-curve analysis to examine the relation between witnessing violence and changes in problem behaviors (drug use, aggression, and delinquency) and attitudes during early adolescence. In Study 1, six waves of data covering 6th to 8th grades were collected from 731 students in urban schools serving mostly African-American…

  17. Organizing effects of adverse early-life condition on body mass, compensatory growth and reproduction : experimental studies in rock pigeons

    NARCIS (Netherlands)

    Hsu, Bin-Yan; Dijkstra, Cor; Groothuis, Ton G. G.

    Early-life food conditions can have profound impact on adult behavioural performance. In song birds, early-life food conditions affect adult physiology and cognitive performance such as song learning and spatial learning. However, effects on reproductive behaviour other than song, such as visual

  18. Effects of Heat-oxidized Soy Protein Isolate on Growth Performance and Digestive Function of Broiler Chickens at Early Age

    Directory of Open Access Journals (Sweden)

    X. Chen

    2015-04-01

    Full Text Available This study was conducted to investigate effects of heat-oxidized soy protein isolate (HSPI on growth performance, serum biochemical indices, apparent nutrient digestibility and digestive function of broiler chickens. A total of 320 1-day-old Arbor Acres chicks were randomly divided into 4 groups with 8 replicates of 10 birds, receiving diets containing soy protein isolate (SPI, control group or the same amount of SPI heated in an oven at 100°C for 1, 4, or 8 h, for 21 days, respectively. The results indicated that compared with the control group, body weight gain and feed intake of birds fed diet containing SPI heated for 8 h were significantly lower (p<0.05. Serum urea nitrogen concentration was higher in the broilers fed diet containing SPI heated for 4 or 8 h at d 21 (p<0.05. In contrast, serum glucose content was decreased by HSPI substitution at d 21 (p<0.05. The relative pancreas weight in HSPI groups was higher than that in the control group at d 21 (p<0.05. Meanwhile, the opposite effect was observed for relative weight of anterior intestine and ileum in broilers fed a diet containing SPI heated for 8 h (p<0.05. Birds fed diets containing SPI heated for 4 or 8 h had a decreased lipase activity in anterior intestinal content at d 14 and 21 (p<0.05, respectively. In addition, the same effect was also noted in broilers given diets containing SPI heated for 1 h at d 21 (p<0.05. Similarly, amylase, protease and trypsin activity in anterior intestinal content were lower in broilers fed diets containing SPI heated for 8 h at d 21 (p<0.05. The apparent digestibility of dry matter (DM from d 8 to 10 and DM, crude protein (CP, and ether extract from d 15 to 17 were lower in broilers fed diets containing SPI heated for 8 h (p<0.05. Besides, birds given diets containing SPI heated for 4 h also exhibited lower CP apparent digestibility from d 15 to 17 (p<0.05. It was concluded that HSPI inclusion can exert a negative influence on the growth

  19. Comparing the Effects of Symbiotic Algae (Symbiodinium) Clades C1 and D on Early Growth Stages of Acropora tenuis

    Science.gov (United States)

    Yuyama, Ikuko; Higuchi, Tomihiko

    2014-01-01

    Reef-building corals switch endosymbiotic algae of the genus Symbiodinium during their early growth stages and during bleaching events. Clade C Symbiodinium algae are dominant in corals, although other clades — including A and D — have also been commonly detected in juvenile Acroporid corals. Previous studies have been reported that only molecular data of Symbiodinium clade were identified within field corals. In this study, we inoculated aposymbiotic juvenile polyps with cultures of clades C1 and D Symbiodinium algae, and investigated the different effect of these two clades of Symbiodinium on juvenile polyps. Our results showed that clade C1 algae did not grow, while clade D algae grew rapidly during the first 2 months after inoculation. Polyps associated with clade C1 algae exhibited bright green fluorescence across the body and tentacles after inoculation. The growth rate of polyp skeletons was lower in polyps associated with clade C1 algae than those associated with clade D algae. On the other hand, antioxidant activity (catalase) of corals was not significantly different between corals with clade C1 and clade D algae. Our results suggested that clade D Symbiodinium algae easily form symbiotic relationships with corals and that these algae could contribute to coral growth in early symbiosis stages. PMID:24914677

  20. [Effect of early nutrition on growth parameters and psychomotor development of children of very low birth weight].

    Science.gov (United States)

    Kocourková, I; Sobotková, D; Pilarová, M; Dittrichová, J; Vondrácek, J; Stranák, Z

    2004-12-01

    The aim of the study was to evaluate influence of early nutrition on growth parameters and psychomotor development of children with very low birth weight (VLBW). A prospective clinical study. Institute for Care of Mother and Child, Prague. Thirty nine children of birth weight 1,000-1,499 were followed up to one year of their corrected age in a prospective study. The group was divided in two groups according to type of nutrition: 17 children (group A) were fed with milk of own mother - "preterm milk", 22 children (group B) were orally fed with mature milk from the Bank of mother milk - "term milk", which was fortified with BMF preparation (Nutricia, Netherlands). Both groups were comparable in basic anthropometric parameters (weight, lenght, circumference of head and thotax) and in psychosocial characteristics of their mothers. Growths parameters were monitored in weekly intervals for approximatelly eight weeks. In the period between 11th and 15th month of corrected age, the children were evaluated by a clinical psychologist on a blind basis in mental a motor development by using Bayley Scales of Infant Development (BSID-II). Statistical analysis was performed by chi-square test and t-test. No statistically significant differences between the two groups in evaluating the growth parameters were observed. The psychological examination demonstrated statistically significant differences in the motor development. The psychomotor developmental index (PVI) proved to be 84.4 +/- 14.6 in the group A and 94.3 +/- 12.5 in the group B (t-test = 2.28, pdevelopment between the two groups. The mean mentel developmental index (MVI) was 98.2 +/- 10.2 in the A group and 101.0 +/- 13.3 in the group B. Result of the study indicate favorable effect of fortification of breast milk in VLBW newborns, especially in view of the observed favorable influence of fortfication on motor development of the children.

  1. Maternal endothelial damage as a disorder shared by early preeclampsia, late preeclampsia and intrauterine growth restriction.

    Science.gov (United States)

    Kwiatkowski, Sebastian; Dołegowska, Barbara; Kwiatkowska, Ewa; Rzepka, Rafał; Marczuk, Natalia; Loj, Beata; Torbè, Andrzej

    2017-10-26

    Preeclampsia (PE) and intrauterine growth restriction (IUGR) are separate disease entities that have frequently been reported as sharing the same pathogenesis. In both of them, angiogenesis disorders and generalized endothelial damage with an accompanying inflammation are the dominant symptoms. In this study, we attempted to prove that both these processes demonstrate the same profile in early PE, late PE and IUGR patients, while the only difference is in the degree of exacerbation of the lesions. In 167 patients divided into four groups, three of those with early PE, late PE and IUGR and one control group, fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), high sensitive c-reactive protein (hsCRP) and fibronectin were determined. The behavior of these parameters in each of the groups was studied, and correlations between them were sought for. Higher concentrations of sFlt-1, hsCRP and fibronectin and a lower concentration of PlGF were found in the study groups compared to the control group. Significant correlations were observed between the factors concerned. The higher values of disordered angiogenesis markers, endothelial damage markers and inflammatory markers both in the PE and the intrauterine growth restriction (IUGR) groups suggest the existence of shared disorders in the development of these pathologies. The correlations between disordered angiogenesis markers and endothelial damage markers argue in favor of a mutual relationship between these two processes in the development of pathologies evolving as secondary to placental ischemia. The results obtained confirm that the lesion profiles are the same in both PE and IUGR patients, which can be utilized in developing common diagnostic criteria.

  2. Do rapid BMI growth in childhood and early-onset obesity offer cardiometabolic protection to obese adults in mid-life?

    DEFF Research Database (Denmark)

    Howe, Laura D; Zimmermann, Esther; Weiss, Ram

    2014-01-01

    BMI growth (7-13 years) using a multilevel model. Early-onset obesity was defined as obesity at examination for national service. OUTCOME MEASUREMENT: We defined metabolic health at the mid-life clinic as non-fasting serum cholesterol fasting glucose ...OBJECTIVE: Some obese individuals have no cardiometabolic abnormalities; they are 'metabolically healthy, but obese' (MHO). Similarly, some non-obese individuals have cardiometabolic abnormalities, that is, 'metabolically at risk, normal weight' (MANW). Previous studies have suggested that early......-onset obesity may be associated with MHO. We aimed to assess whether body mass index (BMI) in childhood and early-onset obesity are associated with MHO. SETTING: General population longitudinal cohort study, Denmark. PARTICIPANTS: From 362 200 young men (mean age 20) examined for Danish national service between...

  3. Multiscale simulations of the early stages of the growth of graphene on copper

    Science.gov (United States)

    Gaillard, P.; Chanier, T.; Henrard, L.; Moskovkin, P.; Lucas, S.

    2015-07-01

    We have performed multiscale simulations of the growth of graphene on defect-free copper (111) in order to model the nucleation and growth of graphene flakes during chemical vapour deposition and potentially guide future experimental work. Basic activation energies for atomic surface diffusion were determined by ab initio calculations. Larger scale growth was obtained within a kinetic Monte Carlo approach (KMC) with parameters based on the ab initio results. The KMC approach counts the first and second neighbours to determine the probability of surface diffusion. We report qualitative results on the size and shape of the graphene islands as a function of deposition flux. The dominance of graphene zigzag edges for low deposition flux, also observed experimentally, is explained by its larger dynamical stability that the present model fully reproduced.

  4. Effect of feeding frequency and feeding rate on growth performance ...

    African Journals Online (AJOL)

    Fish fed at higher feeding rates accumulated significantly more lipid within the body and had associated decreases in moisture, protein, and ash content, but carcass composition was unaffected by feeding frequency. Juvenile pompano show better growth performance when fed 10% BW/day 3 and 6 times a day.

  5. Associations between birth registration and early child growth and development: evidence from 31 low- and middle-income countries.

    Science.gov (United States)

    Jeong, Joshua; Bhatia, Amiya; Fink, Günther

    2018-05-30

    Lack of legal identification documents can impose major challenges for children in low- and middle-income countries (LMICs). The aim of this study was to investigate the association between not having a birth certificate and young children's physical growth and developmental outcomes in LMICs. We combined nationally representative data from the Multiple Indicator Cluster Surveys in 31 LMICs. For our measure of birth registration, primary caregivers reported on whether the child had a birth certificate. Early child outcome measures focused on height-for-age z-scores (HAZ), weight-for-age z-scores (WAZ), weight-for-height z-scores (WHZ), and standardized scores of the Early Childhood Development Index (ECDI) for a subsample of children aged 36-59 months. We used linear regression models with country fixed effects to estimate the relationship between birth registration and child outcomes. In fully adjusted models, we controlled for a variety of child, caregiver, household, and access to child services covariates, including cluster-level fixed effects. In the total sample, 34.7% of children aged 0-59 months did not possess a birth certificate. After controlling for covariates, not owning a birth certificate was associated with lower HAZ (β = - 0.18; 95% CI: -0.23, - 0.14), WAZ (β = - 0.10, 95% CI: -0.13, - 0.07), and ECDI z-scores (β = - 0.10; 95% CI: -0.13, - 0.07) among children aged 36-59 months. Our findings document links between birth registration and children's early growth and development outcomes. Efforts to increase birth registration may be promising for promoting early childhood development in LMICs.

  6. Effects of various weaning times on growth performance, rumen fermentation and microbial population of yellow cattle calves

    Directory of Open Access Journals (Sweden)

    Huiling Mao

    2017-11-01

    Full Text Available Objective This study was conducted to investigate the effects of weaning times on the growth performance, rumen fermentation and microbial communities of yellow cattle calves. Methods Eighteen calves were assigned to a conventional management group that was normally weaned (NW, n = 3 or to early weaned (EW group where calves were weaned when the feed intake of solid feed (starter reached 500 g (EW500, n = 5, 750 g (EW750, n = 5, or 1,000 g (EW1,000, n = 5. Results Compared with NW, the EW treatments increased average daily gain (p0.05, but changes in bacterial composition were found. Conclusion From the present study, it is inferred that EW is beneficial for rumen fermentation, and weaning when the feed intake of the starter reached 750 g showed much better results.

  7. Skeletal muscle protease activities in the early growth and development of wild Atlantic salmon (Salmo salar L.).

    Science.gov (United States)

    Lysenko, Liudmila A; Kantserova, Nadezda P; Kaivarainen, Elena I; Krupnova, Marina Yu; Nemova, Nina N

    2017-09-01

    Growth-related dynamics of intracellular protease activities in four year classes of the Atlantic salmon (Salmo salar L. 1758) parr and smolts inhabiting salmon rivers of northwestern Russia (the White Sea basin) were studied. Cathepsin B, cathepsin D, proteasome, and calpain activities in the skeletal muscles of salmon were assessed to investigate their relative contribution to the total protein degradation as well as to young fish growth process. It was confirmed that calpain activity dominates in salmon muscles while proteasome plays a minor role, in contrast to terrestrial vertebrates. Calpain and proteasome activities were maximal at the early post-larval stage (in parrs 0+) and declined with age (parrs 1+ through 2+) dropping to the lowest level in salmon smolts. Annual growth increments and proteolytic activities of calpains and proteasome in the muscles of salmon juveniles changed with age in an orchestrated manner, while lysosomal cathepsin activities increased with age. Comparing protease activities and growth increments in salmon parr and smolts we suggested that the partial suppression of the protein degradation could be a mechanism stimulating efficient growth in smoltifying salmon. Growth and smoltification-related dynamics of protease activities was quite similar in salmon populations from studied spawning rivers, such as Varzuga and Indera; however, some habitat-related differences were observed. Growth increments and protease activities varied in salmon parr 0+ (but not on later ages) inhabiting either main rivers or small tributaries apparently due to habitat difference on the resources for fish growth. Copyright © 2017 Elsevier Inc. All rights reserved.

  8. X-ray photoemission spectroscopy investigation of the early stages of the oxygen aided Cr growth on Fe(0 0 1)

    Energy Technology Data Exchange (ETDEWEB)

    Brambilla, A., E-mail: alberto.brambilla@polimi.it [CNISM and Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy); Calloni, A.; Picone, A.; Finazzi, M.; Duò, L.; Ciccacci, F. [CNISM and Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo Da Vinci 32, 20133 Milano (Italy)

    2013-02-15

    We report on an X-ray photoemission spectroscopy investigation of the early stages of growth of ultra-thin Cr films on the oxygen-passivated Fe(0 0 1)–p(1 × 1)O surface. The Cr coverages ranged from sub-monolayer up to a few atomic layers. Cr has been grown either at 380 K or at 570 K. Our investigation reveals that during the Cr film growth oxygen floats toward the free surface. The presence of a metallic Cr signal from the very beginning of film growth is discussed in relation to Cr–Fe intermixing and alloy formation at the interface. Our findings are independent from the growth temperature, indicating that it has a very little influence on the chemical interactions at the interface, at variance with the oxygen-free Cr/Fe interface.

  9. X-ray photoemission spectroscopy investigation of the early stages of the oxygen aided Cr growth on Fe(0 0 1)

    International Nuclear Information System (INIS)

    Brambilla, A.; Calloni, A.; Picone, A.; Finazzi, M.; Duò, L.; Ciccacci, F.

    2013-01-01

    We report on an X-ray photoemission spectroscopy investigation of the early stages of growth of ultra-thin Cr films on the oxygen-passivated Fe(0 0 1)–p(1 × 1)O surface. The Cr coverages ranged from sub-monolayer up to a few atomic layers. Cr has been grown either at 380 K or at 570 K. Our investigation reveals that during the Cr film growth oxygen floats toward the free surface. The presence of a metallic Cr signal from the very beginning of film growth is discussed in relation to Cr–Fe intermixing and alloy formation at the interface. Our findings are independent from the growth temperature, indicating that it has a very little influence on the chemical interactions at the interface, at variance with the oxygen-free Cr/Fe interface.

  10. Early childhood growth and cognitive outcomes: Findings from the MAL-ED study.

    Science.gov (United States)

    Scharf, Rebecca J; Rogawski, Elizabeth T; Murray-Kolb, Laura E; Maphula, Angelina; Svensen, Erling; Tofail, Fahmida; Rasheed, Muneera; Abreu, Claudia; Vasquez, Angel Orbe; Shrestha, Rita; Pendergast, Laura; Mduma, Estomih; Koshy, Beena; Conaway, Mark R; Platts-Mills, James A; Guerrant, Richard L; DeBoer, Mark D

    2018-02-02

    Although many studies around the world hope to measure or improve developmental progress in children to promote community flourishing and productivity, growth is sometimes used as a surrogate because cognitive skills are more difficult to measure. Our objective was to assess how childhood measures of anthropometry correlate with measures of child development in low-income settings with high prevalence of poor nutrition and enteric disease, to inform studies considering growth outcomes in the absence of direct child developmental skill assessment. Children from the MAL-ED study were followed from birth to 24 months of age in field sites in 8 low- and middle-income countries across 3 continents. Monthly weight, length, and head circumference measurements were performed. At 24 months, the Bayley Scales of Infant and Toddler Development was administered. We correlated cognitive measures at 24 months with anthropometric measurements from birth to 2 years comparing 3 constructs: absolute attained monthly measures, summative difference in measures from the mean growth curve, and rate of change in measures. Growth faltering at multiple time periods is related to Bayley cognitive outcomes at 24 months. Birthweight, overall growth by 18-24 months, and rate of growth in the 6- to 18-month period were most associated with 24-month developmental scores. In this study, head circumference measurements, compared with length, was more closely linked to cognitive scores at 24 months. Notably, all studies between growth and cognitive outcomes exhibited low r 2 values (0.001-0.049). Anthropometric measures, particularly head circumference, were related to cognitive development, although explaining a low percent of variance. When feasible, direct measures of child development may be more useful. © 2018 John Wiley & Sons Ltd.

  11. Hypoxia and acidification have additive and synergistic negative effects on the growth, survival, and metamorphosis of early life stage bivalves.

    Science.gov (United States)

    Gobler, Christopher J; DePasquale, Elizabeth L; Griffith, Andrew W; Baumann, Hannes

    2014-01-01

    Low oxygen zones in coastal and open ocean ecosystems have expanded in recent decades, a trend that will accelerate with climatic warming. There is growing recognition that low oxygen regions of the ocean are also acidified, a condition that will intensify with rising levels of atmospheric CO2. Presently, however, the concurrent effects of low oxygen and acidification on marine organisms are largely unknown, as most prior studies of marine hypoxia have not considered pH levels. We experimentally assessed the consequences of hypoxic and acidified water for early life stage bivalves (bay scallops, Argopecten irradians, and hard clams, Mercenaria mercenaria), marine organisms of significant economic and ecological value and sensitive to climate change. In larval scallops, experimental and naturally-occurring acidification (pH, total scale  = 7.4-7.6) reduced survivorship (by >50%), low oxygen (30-50 µM) inhibited growth and metamorphosis (by >50%), and the two stressors combined produced additively negative outcomes. In early life stage clams, however, hypoxic waters led to 30% higher mortality, while acidified waters significantly reduced growth (by 60%). Later stage clams were resistant to hypoxia or acidification separately but experienced significantly (40%) reduced growth rates when exposed to both conditions simultaneously. Collectively, these findings demonstrate that the consequences of low oxygen and acidification for early life stage bivalves, and likely other marine organisms, are more severe than would be predicted by either individual stressor and thus must be considered together when assessing how ocean animals respond to these conditions both today and under future climate change scenarios.

  12. Retrieving chronological age from dental remains of early fossil hominins to reconstruct human growth in the past.

    Science.gov (United States)

    Dean, M Christopher

    2010-10-27

    A chronology of dental development in Pan troglodytes is arguably the best available model with which to compare and contrast reconstructed dental chronologies of the earliest fossil hominins. Establishing a time scale for growth is a requirement for being able to make further comparative observations about timing and rate during both dento-skeletal growth and brain growth. The absolute timing of anterior tooth crown and root formation appears not to reflect the period of somatic growth. In contrast, the molar dentition best reflects changes to the total growth period. Earlier initiation of molar mineralization, shorter crown formation times, less root length formed at gingival emergence into functional occlusion are cumulatively expressed as earlier ages at molar eruption. Things that are similar in modern humans and Pan, such as the total length of time taken to form individual teeth, raise expectations that these would also have been the same in fossil hominins. The best evidence there is from the youngest fossil hominin specimens suggests a close resemblance to the model for Pan but also hints that Gorilla may be a better developmental model for some. A mosaic of great ape-like features currently best describes the timing of early hominin dental development.

  13. Practitioner-informed improvements to early childhood intervention performance checklists and practice guides

    Directory of Open Access Journals (Sweden)

    Carl J. Dunst

    2017-08-01

    Full Text Available Results from four early childhood practitioner field tests of performance checklists and early intervention practice guides are reported. Findings from the first field test were used to make changes and improvements in the checklists and practice guides evaluated in the second and third field tests, and findings from the latter two field tests were used to improve the checklist and practice guide evaluated in the fourth field test. Results indicated that changes made in response to practitioners’ suggestions and feedback were associated with (1 progressive increases in the practitioners’ social validity judgments of the checklists, practice guides, and checklist-practice guide correspondence, and (2 progressive decreases in the number of practitioner suggestions and feedback for improving the early intervention materials. The field-test research demonstrates the importance of practitioner input, suggestions, and feedback for improving the usefulness of early childhood intervention practices.

  14. Comparative study on the growth performance of the hybrid catfish ...

    African Journals Online (AJOL)

    Growth performance of the hybrid catfish Heteroclarias reared in concrete and earthen pond systems were investigated in a 92-day experiment. Experiment was conducted using four rectangular ponds (2 concrete and 2 earthen) each measuring 14 × 6 × 1.5 metres in duplicates. The ponds were uniformly limed, fertilized ...

  15. Effects of culture systems on growth and economic performance of ...

    African Journals Online (AJOL)

    IFEOMA PIUS

    2013-07-03

    Jul 3, 2013 ... The effect of culture system on growth and economics performance of Orechromis niloticus ( ... from the Food and Agriculture Organization (FAO) stated ... in the reduction of the availability of natural fish food ..... lowest profit, while algae only had the lowest cost and ... Also, maximizing production in terms of.

  16. Cardiovascular adaptation to extrauterine life after intrauterine growth restriction.

    Science.gov (United States)

    Rodriguez-Guerineau, Luciana; Perez-Cruz, Miriam; Gomez Roig, María D; Cambra, Francisco J; Carretero, Juan; Prada, Fredy; Gómez, Olga; Crispi, Fátima; Bartrons, Joaquim

    2018-02-01

    Introduction The adaptive changes of the foetal heart in intrauterine growth restriction can persist postnatally. Data regarding its consequences for early circulatory adaptation to extrauterine life are scarce. The aim of this study was to assess cardiac morphometry and function in newborns with late-onset intrauterine growth restriction to test the hypothesis that intrauterine growth restriction causes cardiac shape and functional changes at birth. A comprehensive echocardiographic study was performed in 25 neonates with intrauterine growth restriction and 25 adequate-for-gestational-age neonates. Compared with controls, neonates with intrauterine growth restriction had more globular ventricles, lower longitudinal tricuspid annular motion, and higher left stroke volume without differences in the heart rate. Neonates with intrauterine growth restriction also showed subclinical signs of diastolic dysfunction in the tissue Doppler imaging with lower values of early (e') diastolic annular peak velocities in the septal annulus. Finally, the Tei index in the tricuspid annulus was higher in the intrauterine growth restriction group. Neonates with history of intrauterine growth restriction showed cardiac remodelling and signs of systolic and diastolic dysfunction. Overall, there was a significant tendency to worse cardiac function results in the right heart. The adaptation to extrauterine life occurred with more globular hearts, higher stroke volumes but a similar heart rate compared to adequate-for-gestational-age neonates.

  17. Modeling Math Growth Trajectory--An Application of Conventional Growth Curve Model and Growth Mixture Model to ECLS K-5 Data

    Science.gov (United States)

    Lu, Yi

    2016-01-01

    To model students' math growth trajectory, three conventional growth curve models and three growth mixture models are applied to the Early Childhood Longitudinal Study Kindergarten-Fifth grade (ECLS K-5) dataset in this study. The results of conventional growth curve model show gender differences on math IRT scores. When holding socio-economic…

  18. Effect of Bacillus subtilis natto on growth performance in Muscovy ducks

    Directory of Open Access Journals (Sweden)

    T Sheng-Qiu

    2013-09-01

    Full Text Available The aim of the present study was to determine whether dietary Bacillus subtilis natto could affect growth performance of Muscovy ducks. A total of 120 hundred Muscovy ducks at the age of 1 day were randomly assigned to four groups (30 Muscovy ducks/group, and fed with diets supplemented with 0% (control group, 0.1%, 0.2%, and 0.4% Bacillus subtilis natto, respectively during the 6-week feeding period. Weight gain, feed intake and feed conversion efficiency of Muscovy ducks were significantly improved by the dietary addition of Bacillus subtilis natto, and the results were more significant in 0.4% dietary Bacillus subtilis natto treatment group; Also, Bacillus subtilis natto reduced Escherichia coli and Salmonella colonies, and increased lactobacilli population in the ileum and the cecum. Biochemical parameters, including total protein, GOT (glutamic oxaloacetic transaminase, GPT (glutamic pyruvic transaminase, AKP (alkaline phosphatase, triiodothyronine (T3 and tetraiodothyronine (T4 contents (pBacillus subtilis natto was added to the diets (p0.05. The results of the present study indicate that diets with 0.4% Bacillus subtilis natto improved the growth performance of Muscovy ducks by increasing the absorption of protein, simulating hormone secretion, suppressing harmful microflora, and improving the duodenal structure and immune functions of Muscovy ducks. It is suggested that Bacillus subtilis natto is a potential candidate to be used use as a probiotic to improve the growth performance of Muscovy ducks.

  19. Growth anisotropy effect of bulk high temperature superconductors on the levitation performance in the applied magnetic field

    Science.gov (United States)

    Zheng, J.; Liao, X. L.; Jing, H. L.; Deng, Z. G.; Yen, F.; Wang, S. Y.; Wang, J. S.

    2013-10-01

    Growth anisotropies of bulk high temperature superconductors (HTSCs) fabricated by a top-seeded melt texture growth process, that is, different pinning effect in the growth sectors (GSs) and growth sector boundaries (GSBs), possess effect on the macro flux trapping and levitation performance of bulk HTSCs. Previous work (Physics Procedia, 36 (2012) 1043) has found that the bulk HTSC array with aligned GSB pattern (AGSBP) exhibits better capability for levitation and suppression of levitation force decay above a permanent magnet guideway (PMG) compared with misaligned GSB pattern (MGSBP). In this paper, we further examine this growth anisotropy effect on the maglev performance of a double-layer bulk HTSC. In contrast to reported trapped flux cases (Supercond. Sci. Technol. 19 (2006) S466), the two superposed bulk HTSCs with same AGSBP with PMG are found to show better maglev performance. These series of results are helpful and support a new way for the performance optimization of present HTS maglev systems.

  20. Role of nutraceuticals in gut health and growth performance of poultry

    Directory of Open Access Journals (Sweden)

    Sugiharto Sugiharto

    2016-06-01

    Full Text Available The gut is a fundamental organ system which makes up two equally important functions, i.e., the digestion and host defence. To elicit the well-functioning and healthy gut, the dynamic balance of gut ecosystem is of importance. A wide range of factors related to diets and infectious disease agents seem to affect this balance, and subsequently affect the health status and production performance of the chicken. With the ban and/or reduction of the use of antibiotic growth promoters (AGPs in poultry production, the alternatives to AGP are needed especially to preserve the balance of gut microbiota in chicken. This review provides a summary of the potentials and possible mechanisms of action of some alternatives to AGP (referred as nutraceuticals in improving the gut microbial ecosystem and immune system as well as growth performance of poultry.

  1. Green Economy Performance and Green Productivity Growth in China’s Cities: Measures and Policy Implication

    Directory of Open Access Journals (Sweden)

    Jianglong Li

    2016-09-01

    Full Text Available Resource depletion and environmental degradation have become serious challenges for China’s sustainable development. This paper constructs indicators to assess China’s green economy performance and green productivity growth, in which economic expansion, resource conservation and environmental protection need to be incorporated simultaneously. For this purpose, we combine non-radial directional distance function and meta-frontier Malmquist productivity to develop the indicators. The methodology also allows for the decomposition of driving forces of China’s green economy. Moreover, the dataset employed in this paper allows for the evaluation of 275 cities in China during the period 2003–2012. The main findings are as follows. First, most of China’s cities did not perform efficiently in terms of the green economy, with an average score of only 0.233. Second, the growth rate of green productivity is slower than real GDP, and the green productivity growth in China is only moderate. Third, innovation is the main driving force of China’s green productivity growth, but the central region lags behind when it comes to green innovation. Fourth, artificial local protectionism and transport limitations impede the progress of cities that perform ineffectively in the green economy. Based on our empirical findings, we provide policy implications and suggestions for enhancing China’s green economy performance and productivity growth.

  2. Growth and survival of larval and early juvenile lesser sandeel in patchy prey field in the North Sea: An examination using individual-based modelling

    DEFF Research Database (Denmark)

    Gürkan, Zeren; Christensen, Asbjørn; Deurs, Mikael van

    2012-01-01

    -stages in the North Sea. Simulations of patchiness related starvation mortality are able to explain observed patterns of variation in sandeel growth. Reduced prey densities within patches decrease growth and survival rate of larvae and match–mismatch affect growth and survival of larvae with different hatch time due...... by modeling copepod size spectra dynamics and patchiness based on particle count transects and Continuous Plankton Recorder time series data. The study analyzes the effects of larval hatching time, presence of zooplankton patchiness and within patch abundance on growth and survival of sandeel early life...

  3. Increased growth in environmental technology - More capital in early stages; Oekad tillvaext inom miljoeteknik - Mer kapital i tidiga skeden

    Energy Technology Data Exchange (ETDEWEB)

    Stubelius, Andreas; Axelsson, Helene; Fjaellstroem, Mikael; Agnvall, Dag; Olsson, Erik

    2011-07-01

    Swedish environmental technology companies has great growth potential. The transition to a renewable and energy-efficient energy systems and greater attention to the ecosystem, creates a growing international demand for products and services. The Energy Agency has received a government commission to develop proposals that contribute to stronger collaboration and increased communication between those involved in environmental engineering with the aim of increasing environmental technology companies access to capital in the early commercial stages, with particular focus on small and medium-sized players. The Energy Agency submits proposals for action that will lead to increased growth of Swedish environmental technology companies

  4. Black Hole Sign: Novel Imaging Marker That Predicts Hematoma Growth in Patients With Intracerebral Hemorrhage.

    Science.gov (United States)

    Li, Qi; Zhang, Gang; Xiong, Xin; Wang, Xing-Chen; Yang, Wen-Song; Li, Ke-Wei; Wei, Xiao; Xie, Peng

    2016-07-01

    Early hematoma growth is a devastating neurological complication after intracerebral hemorrhage. We aim to report and evaluate the usefulness of computed tomography (CT) black hole sign in predicting hematoma growth in patients with intracerebral hemorrhage. Patients with intracerebral hemorrhage were screened for the presence of CT black hole sign on admission head CT performed within 6 hours after onset of symptoms. The black hole sign was defined as hypoattenuatting area encapsulated within the hyperattenuating hematoma with a clearly defined border. The sensitivity, specificity, and positive and negative predictive values of CT black hole sign in predicting hematoma expansion were calculated. Logistic regression analyses were used to assess the presence of the black hole sign and early hematoma growth. A total of 206 patients were enrolled. Black hole sign was found in 30 (14.6%) of 206 patients on the baseline CT scan. The black hole sign was more common in patients with hematoma growth (31.9%) than those without hematoma growth (5.8%; Phole sign in predicting early hematoma growth were 31.9%, 94.1%, 73.3%, and 73.2%, respectively. The time-to-admission CT scan, baseline hematoma volume, and the presence of black hole sign on admission CT independently predict hematoma growth in multivariate model. The CT black hole sign could be used as a simple and easy-to-use predictor for early hematoma growth in patients with intracerebral hemorrhage. © 2016 American Heart Association, Inc.

  5. Possible effects of an early diagnosis and treatment in patients with growth hormone deficiency: the state of art.

    Science.gov (United States)

    Stagi, Stefano; Scalini, Perla; Farello, Giovanni; Verrotti, Alberto

    2017-09-16

    Growth hormone deficiency (GHD) is a relatively uncommon and heterogeneous endocrine disorder presenting in childhood with short stature. However, during the neonatal period, the metabolic effects of GHD may to require prompt replacement therapy to avoid possible life-threatening complications. An increasing amount of data suggests the importance of an early diagnosis and treatment of GHD because of its auxological, metabolic, and neurodevelopmental features with respect to the patients diagnosed and treated later in life.The available results show favourable auxological outcomes for patients with GHD diagnosed and treated with r-hGH early in life compared with those from patients with GHD who do not receive this early diagnosis and treatment. Because delayed referral for GHD diagnosis and treatment is still frequent, these results highlight the need for more attention in the diagnosis and treatment of GHD.Despite these very encouraging data regarding metabolic and neurodevelopmental features, further studies are needed to better characterize these findings. Overall, the importance of early diagnosis and treatment of GHD needs to be addressed.

  6. Multi-walled carbon nanotubes applied through seed-priming influence early germination, root hair, growth and yield of bread wheat (Triticum aestivum L.).

    Science.gov (United States)

    Joshi, Anjali; Kaur, Simranjeet; Dharamvir, Keya; Nayyar, Harsh; Verma, Gaurav

    2018-06-01

    Reports of multi-walled carbon nanotubes (MWCNTs) incorporated into plants have indicated better yield and productivity, yet the phenomena need in-depth understanding especially when agricultural crops are tested. We primed wheat seeds with MWCNTs to understand the effects on germination, growth, anatomy, physiology and yield. This study, carried out in field conditions, is a step forward over the previous reports. Early germination, excessive root hair, denser stomata and larger root length result in faster growth and higher yield of wheat plants. Denser root hair facilitated the uptake of both water and essential minerals such as phosphorus (P) and potassium (K), which boosted the crop yield by significantly improving grain yield per plant from 1.53 to 2.5 g, a 63% increase. Increase in cell elongation by 80% was recorded, while xylem and phloem sizes dilated to almost 83% and 85% of control, thus enhancing their capacity to conduct water and nutrients. Augmented growth of MWCNT-primed wheat, enhancement in grain number, biomass, stomatal density, xylem-phloem size, epidermal cells, and water uptake is observed while finding no DNA damage. This opens up an entirely new aspect to using cost-effective nanomaterials (the MWCNTs were produced in-house) for enhancing the performance of crop plants. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  7. Stressful Life Events and Predictors of Post-traumatic Growth among High-Risk Early Emerging Adults.

    Science.gov (United States)

    Arpawong, Thalida E; Rohrbach, Louise A; Milam, Joel E; Unger, Jennifer B; Land, Helen; Sun, Ping; Spruijt-Metz, Donna; Sussman, Steve

    2016-01-01

    Stressful life events (SLEs) may elicit positive psychosocial change among youth, referred to as Post-traumatic Growth (PTG). We assessed types of SLEs experienced, degree to which participants reported PTG, and variables predicting PTG across 24 months among a sample of high risk, ethnically diverse early emerging adults. Participants were recruited from alternative high schools ( n = 564; mean age=16.8; 65% Hispanic). Multi-level regression models were constructed to examine the impact of environmental (SLE quantity, severity) and personal factors (hedonic ability, perceived stress, developmental stage, future time orientation) on a composite score of PTG. The majority of participants reported positive changes resulted from their most life-altering SLE of the past two years. Predictors of PTG included fewer SLEs, less general stress, having a future time perspective, and greater identification with the developmental stage of Emerging Adulthood. Findings suggest intervention targets to foster positive adaptation among early emerging adults who experience frequent SLEs.

  8. Growth and population dynamics during early stages of the mangrove Kandelia candel in Halong Bay, North Viet Nam

    Science.gov (United States)

    Thi Ha, Hoang; Duarte, Carlos M.; Tri, Nguyen Hoang; Terrados, Jorge; Borum, Jens

    2003-11-01

    Quantifying the dynamics of the early stages in the life cycle of mangroves is essential to predict the distribution, species composition and structure of mangrove forests, and their maintenance and recovery from perturbations. The growth and population dynamics of two stands of the mangrove Kandelia candel in Halong Bay (Viet Nam) were examined for 1 year. Growth was highly seasonal, with high growth rates and fast internode formation in the summer, dropping to extremely low growth during January-February, the coldest and driest months in the year. In addition, growth and internode formation rates showed important inter-annual variability during the last decade. The complete reproductive period required 7-8 months. Flower initiation was maximal in June and peak propagule maturity occurred in December-January. Only one mature propagule developed for every 67 and 127 inflorescence buds formed at Site 1 and Site 2, respectively. Kandelia candel propagules begun to sink 10 days after being released, and after 18 days all propagules had negative buoyancy. The propagules developed roots within 19-68 days, depending on whether they were held on the water or sediment, and were capable of long range dispersal, for 15-20% of them dispersed more than 100 m within 1 day. The median age of K. candel plants ranged between 8.7 and 5.6 years, with a density of 1900 and 470 plants ha -1, in Sites 1 and 2. Plant mortality was high, with 64 and 74% of the plants surviving after a year at Sites 1 and 2. Life expectancy (i.e. median age-at-death) of only 2.2 and 2.7 years at Sites 1 and 2, respectively, indicates that mortality of young K. candel plants was specially high. Recruitment occurred in early spring, and did not suffice to balance the mortality within the annual period examined. These results suggest that the K. candel stands in Halong Bay might be maintained by a few years of high recruitment which would compensate for generally high mortality rates.

  9. SOILS, FERTILIZATION AND MANAGEMENT OF WATER Halotolerant/alkalophilic bacteria associated with the cyanobacterium Arthrospira platensis (Nordstedt Gomont that promote early growth in Sorghum bicolor (L. Moench

    Directory of Open Access Journals (Sweden)

    Liliana Gómez G

    2012-01-01

    Full Text Available Arthrospira platensis associated bacteria (APAB identified through molecuar biology like Bacillus okhensis, Indibacter alkaliphilus and Halomonas sp., are also producing 3-indol acetic acid (IAA, these bacteria was used in early plant growth promotion tests over Sorghum bicolor, these bioassay was considered indirect evidence to suggest that APAB also may have stimulatory effects over A. platensis growth naturally. I. alkaliphilus and B. okhensis enhanced early germination of S. bicolor seads, with better results than that achieved by Azospirillum brasilense, bacterium used like reference as a common plant growth promoting rizobacteria. The three APAB enhanced significative differences (P≤0.05 over morphoagronomic parameters, I. alkaliphilus and B. okhensis exhibith better resoults in elongation stimulation and root and foliage dry weight. Above evidence suggest this bacteria like plant growth promoting and it recomended testing with A. platensis axenic cultures and its associated bactteri for understanding true interaction between them.

  10. Integrated healthcare networks' performance: a growth curve modeling approach.

    Science.gov (United States)

    Wan, Thomas T H; Wang, Bill B L

    2003-05-01

    This study examines the effects of integration on the performance ratings of the top 100 integrated healthcare networks (IHNs) in the United States. A strategic-contingency theory is used to identify the relationship of IHNs' performance to their structural and operational characteristics and integration strategies. To create a database for the panel study, the top 100 IHNs selected by the SMG Marketing Group in 1998 were followed up in 1999 and 2000. The data were merged with the Dorenfest data on information system integration. A growth curve model was developed and validated by the Mplus statistical program. Factors influencing the top 100 IHNs' performance in 1998 and their subsequent rankings in the consecutive years were analyzed. IHNs' initial performance scores were positively influenced by network size, number of affiliated physicians and profit margin, and were negatively associated with average length of stay and technical efficiency. The continuing high performance, judged by maintaining higher performance scores, tended to be enhanced by the use of more managerial or executive decision-support systems. Future studies should include time-varying operational indicators to serve as predictors of network performance.

  11. Effect of yoghurt waste on gut morphology and growth performance ...

    African Journals Online (AJOL)

    The experiment was carried out to determine the effect of yoghurt waste on intestinal morphology and growth performance of pigs weaned at 7 weeks of age. A total of 20 weaned pigs (15.6 ± 2kg, initial body weight {BW}) were randomly assigned in groups of four, to 5 experimental treatments in a randomized block design.

  12. Effects of culture systems on growth and economic performance of ...

    African Journals Online (AJOL)

    The effect of culture system on growth and economics performance of Orechromis niloticus (Nile tilapia) in concrete tanks was investigated. Four outdoor concrete tanks measuring 2.5 x 2 m was used for the study for 24 weeks culture period. The culture systems included the use of algae only at the stocking rates of 4 ...

  13. Growth Performance of Red Sokoto Bucks Fed Inclusion levels of ...

    African Journals Online (AJOL)

    This study was carried out to evaluate the growth performance of red Sokoto bucks fed two (2) inclusion levels of rawwater soaked and lime soaked Hibiscus sabdariffa seeds in rice offal based diets. A total of twenty one (21) red Sokoto bucks were randomly allotted into seven treatments with three (3) bucks per group while ...

  14. The Performing Arts: Music, Dance, and Theater in the Early Years

    Science.gov (United States)

    Koralek, Derry

    2010-01-01

    This article presents an interview with Mimi Brodsky Chenfeld, a longtime early childhood teacher, author, teacher educator, and advocate for integrating the arts with every aspect of the curriculum. In this interview, Chenfeld shares her thoughts about the performing arts: music, dance, and theater. She explains why it is important for young…

  15. Early Change in Stroke Size Performs Best in Predicting Response to Therapy.

    Science.gov (United States)

    Simpkins, Alexis Nétis; Dias, Christian; Norato, Gina; Kim, Eunhee; Leigh, Richard

    2017-01-01

    Reliable imaging biomarkers of response to therapy in acute stroke are needed. The final infarct volume and percent of early reperfusion have been used for this purpose. Early fluctuation in stroke size is a recognized phenomenon, but its utility as a biomarker for response to therapy has not been established. This study examined the clinical relevance of early change in stroke volume and compared it with the final infarct volume and percent of early reperfusion in identifying early neurologic improvement (ENI). Acute stroke patients, enrolled between 2013 and 2014 with serial magnetic resonance imaging (MRI) scans (pretreatment baseline, 2 h post, and 24 h post), who received thrombolysis were included in the analysis. Early change in stroke volume, infarct volume at 24 h on diffusion, and percent of early reperfusion were calculated from the baseline and 2 h MRI scans were compared. ENI was defined as ≥4 point decrease in National Institutes of Health Stroke Scales within 24 h. Logistic regression models and receiver operator characteristics analysis were used to compare the efficacy of 3 imaging biomarkers. Serial MRIs of 58 acute stroke patients were analyzed. Early change in stroke volume was significantly associated with ENI by logistic regression analysis (OR 0.93, p = 0.048) and remained significant after controlling for stroke size and severity (OR 0.90, p = 0.032). Thus, for every 1 mL increase in stroke volume, there was a 10% decrease in the odds of ENI, while for every 1 mL decrease in stroke volume, there was a 10% increase in the odds of ENI. Neither infarct volume at 24 h nor percent of early reperfusion were significantly associated with ENI by logistic regression. Receiver-operator characteristic analysis identified early change in stroke volume as the only biomarker of the 3 that performed significantly different than chance (p = 0.03). Early fluctuations in stroke size may represent a more reliable biomarker for response to therapy than the

  16. Growth Performance of Pekin Ducks Fed with Golden Snail and Fresh Banana Peelings

    Directory of Open Access Journals (Sweden)

    Ulep, LJL.

    1995-01-01

    Full Text Available The growth performance and economics of feeding confined Pekin ducks with three different levels of golden snail fresh meat and banana peelings in equal percentage for replacing 50 %, 70 % or 90 % of the commercial feed of the diet was studied. Body weight gains and feed consumption of ducks, cost of feed and profit above feed and stock cost different significantly among treatments. Feed conversion varied during the first month of feeding but became comparable after the second month. Ducks fed the diet with 45 % banana peel and 45 % golden snail meat gave the best performance, were the most economical and yielded the highest profit. Snail meat and banana peeling utilization as replacement to commercial diet for ducks is advantageaous in terms of growth performance and cost benefit.

  17. INVESTMENT FUNDS’ PERFORMANCE AND ECONOMIC GROWTH

    Directory of Open Access Journals (Sweden)

    Apolzan Carmen Maria

    2012-07-01

    Full Text Available In this paper we examine the performance of investment funds during the period 2006-2010, intending to comprise the portfolio performance’s dynamics before, during and after the present economic and financial crises climax. We categorize investment funds according to their investment strategy and geographical focus and distinguish a number of 11 classes. In order to analyze their returns’ dynamics, we create a fund performance index for each category using principal components method. The instability created in financial system in 2007 had a direct impact on institutional investors’ portfolios regardless of investment strategy, effects that have rapidly propagated on real economy. Analyzing index’s dynamics correlated with economic growth we conclude that financial and economic environment react in the same direction, but with a certain time delay, to instability factors. We also underline the major impact of boom and bust evolution of financial markets on real economy, cause of the current economic and financial crises.

  18. Improved growth performance in rainbow trout Oncorhynchus mykiss reared at high densities is linked to increased energy retention

    DEFF Research Database (Denmark)

    Laursen, Danielle Caroline; Larsen, Bodil Katrine; Skov, Peter Vilhelm

    2015-01-01

    performance. Manipulating aggressive behaviour through density may have advantages from a practical perspective. In the present study the energetic expenditure of rainbow trout held at three densities, 25, 80 and 140 kg m(-3), were related to growth performance parameters. Measurements for growth performance...

  19. High Resolution AFM and Single-Cell Resonance Raman Spectroscopy of Geobacter sulfurreducens Biofilms Early in Growth

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, Nikolai, E-mail: nikolai.lebedev@nrl.navy.mil; Strycharz-Glaven, Sarah M.; Tender, Leonard M., E-mail: nikolai.lebedev@nrl.navy.mil [Center for Biomolecular Science and Engineering, US Naval Research Laboratory, Washington, DC (United States)

    2014-08-21

    Atomic force microscopy and confocal resonance Raman microscopy (CRRM) of single-cells were used to study the transition of anode-grown Geobacter sulfurreducens biofilms from lag phase (initial period of low current) to exponential phase (subsequent period of rapidly increasing current). Results reveal that lag phase biofilms consist of lone cells and tightly packed single-cell thick clusters crisscrossed with extracellular linear structures that appears to be comprised of nodules approximately 20 nm in diameter aligned end to end. By early exponential phase, cell clusters expand laterally and a second layer of closely packed cells begins to form on top of the first. Abundance of c-type cytochromes (c-Cyt) is threefold greater in two-cell thick regions than in one-cell thick regions. The results indicate that early biofilm growth involves two transformations. The first is from lone cells to two-dimensionally associated cells during lag phase when current remains low. This is accompanied by formation of extracellular linear structures. The second is from two- to three-dimensionally associated cells during early exponential phase when current begins to increase rapidly. This is accompanied by a dramatic increase in c-Cyt abundance.

  20. High Resolution AFM and Single-Cell Resonance Raman Spectroscopy of Geobacter sulfurreducens Biofilms Early in Growth

    International Nuclear Information System (INIS)

    Lebedev, Nikolai; Strycharz-Glaven, Sarah M.; Tender, Leonard M.

    2014-01-01

    Atomic force microscopy and confocal resonance Raman microscopy (CRRM) of single-cells were used to study the transition of anode-grown Geobacter sulfurreducens biofilms from lag phase (initial period of low current) to exponential phase (subsequent period of rapidly increasing current). Results reveal that lag phase biofilms consist of lone cells and tightly packed single-cell thick clusters crisscrossed with extracellular linear structures that appears to be comprised of nodules approximately 20 nm in diameter aligned end to end. By early exponential phase, cell clusters expand laterally and a second layer of closely packed cells begins to form on top of the first. Abundance of c-type cytochromes (c-Cyt) is threefold greater in two-cell thick regions than in one-cell thick regions. The results indicate that early biofilm growth involves two transformations. The first is from lone cells to two-dimensionally associated cells during lag phase when current remains low. This is accompanied by formation of extracellular linear structures. The second is from two- to three-dimensionally associated cells during early exponential phase when current begins to increase rapidly. This is accompanied by a dramatic increase in c-Cyt abundance.

  1. Unraveling the effect of structurally different classes of insecticide on germination and early plant growth of soybean [Glycine max (L.) Merr].

    Science.gov (United States)

    Dhungana, Sanjeev Kumar; Kim, Il-Doo; Kwak, Hwa-Sook; Shin, Dong-Hyun

    2016-06-01

    Although a considerable number of studies about the effect of different insecticides on plant physiology and metabolism have been carried out, research work about the comparative action of structurally different classes of insecticide on physiological and biochemical properties of soybean seed germination and early growth has not been found. The objective of this study was to investigate the effect of different classes of insecticides on soybean seed germination and early plant growth. Soybean seeds of Bosuk cultivar were soaked for 24h in distilled water or recommended dose (2mLL(-1), 1mLL(-1), 0.5gL(-1), and 0.5gL(-1) water for insecticides Mepthion, Myungtaja, Actara, and Stonate, respectively) of pesticide solutions of four structurally different classes of insecticides - Mepthion (fenitrothion; organophosphate), Myungtaja (etofenprox; pyrethroid), Actara (thiamethoxam; neonicotinoid), and Stonate (lambda-cyhalothrin cum thiamethoxam; pyrethroid cum neonicotinoid) - which are used for controlling stink bugs in soybean crop. Insecticides containing thiamethoxam and lamda-cyhalothrin cum thiamethoxam showed positive effects on seedling biomass and content of polyphenol and flavonoid, however fenitrothion insecticide reduced the seed germination, seed and seedling vigor, and polyphenol and flavonoid contents in soybean. Results of this study reveal that different classes of insecticide have differential influence on physiologic and metabolic actions like germination, early growth, and antioxidant activities of soybean and this implies that yield and nutrient content also might be affected with the application of different types of insecticide. Copyright © 2015 Elsevier B.V. All rights reserved.

  2. The scientific foundations and associated injury risks of early soccer specialisation.

    Science.gov (United States)

    Read, Paul J; Oliver, Jon L; De Ste Croix, Mark B A; Myer, Gregory D; Lloyd, Rhodri S

    2016-12-01

    Early specialisation is characterised by formal participation in a single sport at the exclusion of others. Limited data are available to support this approach in the development of soccer players who attain elite status later in life. Of growing concern is the associated increased risk of injury and suggestions that single sport specialisation is a risk factor independent of age, growth, biological maturation and training volumes. In the United Kingdom, elite soccer organisations have recently adopted an early sport specialisation approach following the introduction of the Elite Player Performance Plan. A key tenet of this programme is increased opportunities for training through a marked rise in the specified on-pitch hours per week. The accumulation of high training hours may be less of a relevant marker for success, and the impact of such a significant increase in training volume for young athletes who are experiencing a range of growth and maturational processes is currently unknown. This critical commentary includes an evidence-based discussion of the effectiveness of early sport specialisation and the potential injury risks associated with such programmes placing a specific focus on elite male youth soccer players. Available data indicate that modifications to the existing Elite Player Performance Plan framework could enhance players' development and reduce injury risk. Proposed alterations include reduced volume of soccer-specific training at key stages of growth and maturation and guidelines for the provision of a greater variety of physical activities that are integrated within other programme components.

  3. Growth performance of commercial temperate mushrooms Agaricus bisporus and Hypsizygus sp. under local environment

    International Nuclear Information System (INIS)

    Rosnani Abdul Rashid; Mat Rasol Awang; Hassan Hamdani Hassan Mutaat; Mohd Meswan Maskom

    2010-01-01

    To date, the Malaysian mushroom industry focuses on only seven species of mushroom for commercial purpose. To expand and further develop the mushroom industry, new mushroom species should be introduced into our local market. Temperate mushrooms are possible to be cultivated commercially in Malaysia but the optimisation of growth performance for high quality spawn and high mushroom yield need to be studied. In the present study the growth performance of mycelia of Agaricus bisporus and Hypsizygus sp. on culture media and substrates were investigated. Four types of culture media, viz. Potato Dextrose Agar (PDA), Nutrient Agar (NA), Malt Yeast Extract (MYE) and Complete Yeast Media (CYM) were used to determine the suitable culturing media for mycelial growth. The mycelia were inoculated on oil palm empty fruit bunch (EFB) and sawdust substrate and incubated at room temperature and in a low temperature in incubation room (10 - 12 degree Celsius). From the observation, Agaricus bisporus grew better on Malt Yeast Extract (MYE) medium with a growth rate of 0.306 cm/ day. Complete Yeast Media (CYM) was found more suitable for Hypsizygus sp. with a growth rate of 1.049 cm/ day. The linear growth rate of mycelium as measured on the surface of mushroom bag of Agaricus bisporus on EFB incubated at room temperature was 0.4364 cm/ day and cool temperature was 0.055 cm/ day. For Hypsizygus sp. the linear growth rate of the mycelium was 2.11 cm/ day. The linear growth of Hypsizygus sp. on sawdust substrate incubated in cool temperature was 1.4 cm/ day. (author)

  4. IT and Fast Growth Small-to-Medium Enterprise Performance: An Empirical Study in Australia

    Directory of Open Access Journals (Sweden)

    Rui Bi

    2015-10-01

    Full Text Available Information technology (IT is regarded as a facilitator for both small and large firms to speed up transactions between firms and their suppliers and customers, achieve real-time communication, lower transaction costs, and enhance speed and flexibility. However, understanding whether and how IT helps small-to-medium enterprises (SMEs to create business value still remains unclear. Drawing upon resource-based view theory, source-positional advantage-performance framework, we develop and test a theoretical model to explore the interrelationships between IT resources (IT expertise, IT infrastructure, IT capability (IT integration, IT-enabled inter-firm partnership processes (activity integration, coordination, partnership enhancement, and organizational performance in the fast growth SME context. We propose that IT business value depends on how firms employ IT resources to develop IT capability which facilitates inter-firm partnership processes along value chains. Structural equation modeling is employed to test our theoretical conceptualization of 310 Australian fast-growth SMEs across different industrial sectors. Results show that IT contributes to fast growth SME performance through the development of IT capability and enhancement of inter-firm partnership activities. This research highlights the role of IT in business value creation and the ways in which IT is used by fast growth SMEs to foster core business competencies.

  5. Trajectories of BMI from early childhood through early adolescence: SES and psychosocial predictors.

    Science.gov (United States)

    Lane, Sean P; Bluestone, Cheryl; Burke, Christopher T

    2013-02-01

    This study examined the ways in which body mass index (BMI) percentile - an identified risk factor for overweight and cardiovascular disease in adulthood - develops from birth through early adolescence. In addition, we examined whether psychosocial factors, such as parenting style and maternal depression, mediated the link between socio-economic status (SES) and BMI growth. Design. Data were obtained from phases 1-3 of the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care and Youth Development (SECCYD) - a longitudinal study that followed children from 10 communities in the United States from birth to age 11. We applied growth mixture models to identify distinct subtypes of BMI development. Within these models, we performed between- and within-class mediation analyses to examine whether SES predicted class membership or differences in development within each class via maternal depression and parenting styles. Results identified three prototypic trajectories of BMI percentile growth, elevated, steady increase, and stable. We found evidence for both between- and within-class mediation, suggesting multiple pathways by which SES can affect BMI development. These findings add to the research that suggests that being in a family with a low SES is associated with falling into patterns of development characterized by early and lasting increases in BMI relative to one's peers, and that this association is partly accounted for by maternal depression and parenting styles. What is already known? Past research has found evidence that patterns of childhood overweight are impacted by socioeconomic status through psychosocial factors like parenting and depression. This evidence is often limited to individual points in time where neglectful, permissive, and authoritarian parenting and higher levels of maternal depression are associated with higher levels of overweight status among children from infancy to adolescence. However, little

  6. The public health challenge of early growth failure in India.

    Science.gov (United States)

    Young, M F; Martorell, R

    2013-05-01

    Recent recognition of the early onset and high prevalence of wasting (30%) and stunting (20%) among infants 0-5 months in India draws attention to the need to understand the causes and develop prevention strategies. Such growth failure has dire consequences in the short (increased mortality) and long-term (loss of human capital and increased risk of chronic diseases). Food interventions before 6 months will increase morbidity/mortality through contamination in settings of poor sanitation and hygiene. Waiting to improve nutrition only after the initiation of complementary feeding at 6 months is a missed opportunity and may permanently alter life trajectory and potential. This underscores the importance of maternal nutrition. Iron and folic acid and protein energy supplementation during pregnancy are interventions that can improve maternal nutrition and birth outcomes. Maternal supplementation during lactation should be considered as a means to improve maternal and child outcomes, although the evidence needs strengthening. Support and counseling are also required to improve maternal diets and promote exclusive breastfeeding. Programs focused on improving maternal nutrition across the continuum of preconception, pregnancy and lactation are likely to have the greatest impact as mothers are central gatekeepers to the health and future of their children.

  7. Influence of nitrogen sources on growth and fermentation performance of different wine yeast species during alcoholic fermentation

    DEFF Research Database (Denmark)

    Kemsawasd, Varongsiri; Monteiro Lomba Viana, Tiago; Ardö, Ylva

    2015-01-01

    -Saccharomyces yeast species (Lachancea thermotolerans, Metschnikowia pulcherrima, Hanseniaspora uvarum and Torulaspora delbrueckii) was investigated during alcoholic fermentation. Briefly, the N-sources with beneficial effects on all performance parameters (or for the majority of them) for each yeast species were...... for L. thermotolerans, H. uvarum and M. pulcherrima, single amino acids affected growth and fermentation performance to the same extent as the mixtures. Moreover, we found groups of N-sources with similar effects on the growth and/or fermentation performance of two or more yeast species. Finally...... species under oxygen-limited conditions, which, in turn, may be used to, e.g. optimize growth and fermentation performance of the given yeast upon N-source supplementation during wine fermentations....

  8. Growth anisotropy effect of bulk high temperature superconductors on the levitation performance in the applied magnetic field

    International Nuclear Information System (INIS)

    Zheng, J.; Liao, X.L.; Jing, H.L.; Deng, Z.G.; Yen, F.; Wang, S.Y.; Wang, J.S.

    2013-01-01

    Highlights: • The single-layer bulk HTSC with AGSBP obtains better levitation performance than that of MGSBP. • The double-layer bulk with AGSBP obtains better levitation performance than that of MGSBP too. • The double-layer bulk finding is contrast to MGSBP if pursuing high trapped field. • The optimization is highlighted by simple and easy operation, thus economical in the practice. -- Abstract: Growth anisotropies of bulk high temperature superconductors (HTSCs) fabricated by a top-seeded melt texture growth process, that is, different pinning effect in the growth sectors (GSs) and growth sector boundaries (GSBs), possess effect on the macro flux trapping and levitation performance of bulk HTSCs. Previous work (Physics Procedia, 36 (2012) 1043) has found that the bulk HTSC array with aligned GSB pattern (AGSBP) exhibits better capability for levitation and suppression of levitation force decay above a permanent magnet guideway (PMG) compared with misaligned GSB pattern (MGSBP). In this paper, we further examine this growth anisotropy effect on the maglev performance of a double-layer bulk HTSC. In contrast to reported trapped flux cases (Supercond. Sci. Technol. 19 (2006) S466), the two superposed bulk HTSCs with same AGSBP with PMG are found to show better maglev performance. These series of results are helpful and support a new way for the performance optimization of present HTS maglev systems

  9. Growth anisotropy effect of bulk high temperature superconductors on the levitation performance in the applied magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, J., E-mail: jzheng@swjtu.edu.cn; Liao, X.L.; Jing, H.L.; Deng, Z.G.; Yen, F.; Wang, S.Y.; Wang, J.S.

    2013-10-15

    Highlights: • The single-layer bulk HTSC with AGSBP obtains better levitation performance than that of MGSBP. • The double-layer bulk with AGSBP obtains better levitation performance than that of MGSBP too. • The double-layer bulk finding is contrast to MGSBP if pursuing high trapped field. • The optimization is highlighted by simple and easy operation, thus economical in the practice. -- Abstract: Growth anisotropies of bulk high temperature superconductors (HTSCs) fabricated by a top-seeded melt texture growth process, that is, different pinning effect in the growth sectors (GSs) and growth sector boundaries (GSBs), possess effect on the macro flux trapping and levitation performance of bulk HTSCs. Previous work (Physics Procedia, 36 (2012) 1043) has found that the bulk HTSC array with aligned GSB pattern (AGSBP) exhibits better capability for levitation and suppression of levitation force decay above a permanent magnet guideway (PMG) compared with misaligned GSB pattern (MGSBP). In this paper, we further examine this growth anisotropy effect on the maglev performance of a double-layer bulk HTSC. In contrast to reported trapped flux cases (Supercond. Sci. Technol. 19 (2006) S466), the two superposed bulk HTSCs with same AGSBP with PMG are found to show better maglev performance. These series of results are helpful and support a new way for the performance optimization of present HTS maglev systems.

  10. Re-parametrization of a swine model to predict growth performance of broilers

    OpenAIRE

    Dukhta, G.; van Milgen, Jacob; Kövér, G.; Halas, V.

    2017-01-01

    The aim of the study was to investigate whether a pig growth model is suitable to be modified and adapted for broilers. As monogastric animals, pigs and poultry share many similarities in their digestion and metabolism, many structures (body protein and lipid stores) and the nutrient flows of the underlying metabolic pathways are similar among species. For that purpose, the InraPorc model was used as a basis to predict growth performance and body composition at slaughter in broilers. First...

  11. Schooling and wage income losses due to early-childhood growth faltering in developing countries: national, regional, and global estimates.

    Science.gov (United States)

    Fink, Günther; Peet, Evan; Danaei, Goodarz; Andrews, Kathryn; McCoy, Dana Charles; Sudfeld, Christopher R; Smith Fawzi, Mary C; Ezzati, Majid; Fawzi, Wafaie W

    2016-07-01

    The growth of >300 million children purchasing power parity-adjusted exchange rates. At the regional level, economic costs were largest in South Asia ($46.6 billion; 95% CI: $33.3 billion, $61.1 billion), followed by Latin America ($44.7 billion; 95% CI: $19.2 billion, $74.6 billion) and sub-Saharan Africa ($34.2 billion; 95% CI: $24.4 billion, $45.3 billion). Our results indicate that the annual cost of early-childhood growth faltering is substantial. Further investment in scaling up effective interventions in this area is urgently needed and likely to yield long run benefits of $3 for every $1 invested. © 2016 American Society for Nutrition.

  12. Growth and Divergence in Manufacturing Performance in South and East Asia

    NARCIS (Netherlands)

    Timmer, Marcel P.; Szirmai, Adam

    1997-01-01

    The growth experience in manufacturing in South and East Asian economies is well documented. Less is known about absolute levels of economic performance. This paper presents a star comparison of six Asian economies (China, India, Indonesia, Japan, South Korea and Taiwan) and the USA, the world

  13. A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction.

    Science.gov (United States)

    Kwiatkowski, Sebastian; Dołęgowska, Barbara; Kwiatkowska, Ewa; Rzepka, Rafał; Torbè, Andrzej; Bednarek-Jędrzejek, Magdalena

    2016-01-01

    Preeclampsia and intrauterine growth restriction are two separate disease entities that, according to numerous reports, share the same pathogenesis. In both, angiogenesis disorders and generalized inflammation are the dominant symptoms. In this study, we hypothesized that both diseases demonstrate the same profile in early preeclampsia, late preeclampsia, and intrauterine growth restriction patients, with the only difference being the degree of exacerbation of lesions. One hundred sixty-seven patients were enrolled in the study and divided into four groups: early preeclampsia, late preeclampsia, and intrauterine growth restriction groups, and one control group. Concentrations of the angiogenesis and inflammatory markers soluble fms-like tyrosine kinase receptor 1, placental growth factor, high-sensitivity C-reactive protein, and interleukin-6 were determined, and the behavior of these markers and correlations among them were studied. Higher concentrations of soluble fms-like tyrosine kinase receptor 1, high-sensitivity C-reactive protein, and interleukin-6 and a lower concentration of placental growth factor were observed in the study groups compared with the control group. No differences in concentrations of the studied markers were found among the study groups but significant correlations were observed. The higher values for the angiogenesis and inflammatory markers both in preeclampsia patients and patients with intrauterine growth restriction of placental origin compared with the control group suggest the existence of the same underlying disorders in the development of these pathologies. The observed mutual correlations for disordered angiogenesis and inflammatory markers are suggestive of a mutual relationship between these processes in the development of pathologies evolving secondary to placental ischemia. The same lesion profile was observed for both preeclampsia and 'placental' intrauterine growth restriction patients, which could be used in developing

  14. Growth ring analysis of fossil coniferous woods from early cretaceous of Araripe Basin (Brazil

    Directory of Open Access Journals (Sweden)

    Etiene F. Pires

    2011-06-01

    Full Text Available Growth ring analysis on silicified coniferous woods from the Missão Velha Formation (Araripe Basin - Brazil has yielded important information about periodicity of wood production during the Early Cretaceous in the equatorial belt. Despite warm temperatures, dendrological data indicate that the climate was characterized by cyclical alternation of dry and rainy periods influenced by cyclical precipitations, typical of tropical wet and dry or savanna climate. The abundance of false growth rings can be attributed to both occasional droughts and arthropod damage. The present climate data agree with palaeoclimatic models that inferred summer-wet biomes for the Late Jurassic/Early Cretaceous boundary in the southern equatorial belt.A partir de análise de anéis de crescimento em lenhos de coníferas silicificadas provenientes da Formação Missão Velha(Bacia do Araripe - Brasil, obteve-se importantes informações a respeito da periodicidade de produção lenhosa duranteo início do Cretáceo, na região do equador. Apesar das estimativas de temperatura apresentarem-se elevadas, os dados dendrológicos indicam que o clima foi caracterizado pela alternância cíclica de períodos secos e chuvosos, influenciado por precipitações periódicas, típico das condições atuais de climatropical úmido e seco ou savana. A abundância de falsosanéis de crescimento pode ser atribuída tanto a secas ocasionais quanto a danos causados por artrópodes. Os dados paleoclimáticos aqui obtidos corroboram com modelos paleoclimáticos que inferem a ocorrência de um bioma de verões úmidos para o limite Neojurássico/Eocretáceo ao sul do equador.

  15. Aloysia triphylla in the zebrafish food: effects on physiology, behavior, and growth performance.

    Science.gov (United States)

    Zago, Daniane C; Santos, Alessandro C; Lanes, Carlos F C; Almeida, Daniela V; Koakoski, Gessi; de Abreu, Murilo S; Zeppenfeld, Carla C; Heinzmann, Berta M; Marins, Luis F; Baldisserotto, Bernardo; Barcellos, Leonardo J G; Cunha, Mauro A

    2018-04-01

    Dietary supplements are commonly used by animals and humans and play key roles in diverse systems, such as the immune and reproductive systems, and in metabolism. Essential oils (EOs), which are natural substances, have potential for use in food supplementation; however, their effects on organisms remain to be elucidated. Here, we examine the effects of dietary Aloysia triphylla EO supplementation on zebrafish behavior, metabolism, stress response, and growth performance. We show that fish fed diets containing A. triphylla EO presented an anxiolytic response, with reduced exploratory activity and oxygen consumption; no changes were observed in neuroendocrine stress axis functioning and growth was not impaired. Taken together, these results suggest that the A. triphylla EO supplementation is a strong candidate for use in feed, since it ensures fish welfare (anxiolytic behavior) with decreased oxygen consumption. This makes it suitable for use in high-density production systems without causing damage to the neuroendocrine stress axis and without growth performance being impaired.

  16. Early Detection of At-Risk Undergraduate Students through Academic Performance Predictors

    Science.gov (United States)

    Rowtho, Vikash

    2017-01-01

    Undergraduate student dropout is gradually becoming a global problem and the 39 Small Islands Developing States (SIDS) are no exception to this trend. The purpose of this research was to develop a method that can be used for early detection of students who are at-risk of performing poorly in their undergraduate studies. A sample of 279 students…

  17. The Impact of Export Dynamics on a Firm’s Growth

    Directory of Open Access Journals (Sweden)

    Jerzy Cieślik

    2014-09-01

    Full Text Available Purpose: This research aimed to identify the prevalence and particular characteristics of export-driven growth as opposed to those of the domestic market. It examined how the relative dynamics of export sales vs. domestic sales were affected by internationalization intensity (FSTS, age of the fi rm, early internationalization, size of the fi rm and industry technological level. Similarly, it examined the impact of sales growth and its direction (domestic vs. export-driven on company performance. Methodology: The analysis was based on panel data from approximately 300 manufacturing fi rms in the Mazovia region of Poland that were engaged in sustained export operations during 2003 to 2010. Several hypotheses were tested regarding factors affecting the growth dynamics of regular exporters as well as their performance (productivity. Findings: This research proved that only a small percentage (less than 10% of fi rms reached the status of regular exporter, although regular exporters engaged in international operations shortly after their foundation, They formed a distinct category of early internationalizing firms. For the management of young, ambitious ventures, achieving regularity in their initial export operations represented a major challenge. Implications: Regularity of international sales is crucial for export performance, both at the enterprise and country levels. This implies that export promotion efforts should concentrate on growth-oriented fi rms, specifi cally to assist them in reaching regular exporter status shortly after initiating sales outside the domestic market. Originality: The analysis of the internationalization process was expanded by adding the regularity dimension,which has been rarely addressed in the extant literature.

  18. Prayer and Performance in Early Modern English Literature: Gesture, Word and Devotion

    DEFF Research Database (Denmark)

    Sterrett, Joseph William

    2018-01-01

    did the performance of prayer reflect shifts in social perspectives and customs? These questions are addressed in two ways, first by discussing prayer as a social act and second by exploring the representation of prayer on stage and in literature. Organised in this way, the book makes an explicit......”: invocation as prayer in Milton’s Poetic Imagination’ Chapter 16:Helen Wilcox, ‘ ‘Your suit is granted”: Performing Prayer in Early Modern English Poetry’...

  19. Metabolic changes in early lactation and impaired reproductive performance in dairy cows.

    NARCIS (Netherlands)

    Jorritsma, R.; Wensing, T.; Kruip, T.A.M.; Vos, P.L.A.M.; Noordhuizen, J.P.T.M.

    2003-01-01

    This review addresses the suggestion that the decline in dairy reproductive performance, as increasingly observed these days, may be due to a hampered process of metabolic adaptation in early lactating cows. In our opinion, adaptation to the negative energy balance is a gradual process. Because

  20. Growth problems of stellar black holes in early galaxies

    Science.gov (United States)

    Orofino, M. C.; Ferrara, A.; Gallerani, S.

    2018-06-01

    The nature of the seeds of the observed high-z super-massive black holes (SMBH) is unknown. Although different options have been proposed, involving e.g. intermediate mass direct collapse black holes, BH remnants of massive stars remain the most natural explanation. To identify the most favorable conditions (if any) for their rapid growth, we study the accretion rate of a M• = 100M⊙ BH formed in a typical z = 10 galaxy under different conditions (e.g. galaxy structure, BH initial position and velocity). We model the galaxy baryonic content and follow the BH orbit and accretion history for 300 Myr (the time span in 10 > z > 7), assuming the radiation-regulated accretion model by Park & Ricotti (2013). We find that, within the limits of our model, BH seeds cannot grow by more than 30%, suggesting that accretion on light-seed models are inadequate to explain high-z SMBH. We also compute the X-ray emission from such accreting stellar BH population in the [0.5 - 8] keV band and find it comparable to the one produced by high-mass X-ray binaries. This study suggests that early BHs, by X-ray pre-heating of the intergalactic medium at cosmic dawn, might leave a specific signature on the HI 21 cm line power spectrum potentially detectable with SKA.

  1. Growth performance and gastrointestinal responses of broiler chickens fed corn-soybean meal diet without or with exogenous epidermal growth factor upon challenge with Eimeria.

    Science.gov (United States)

    Kim, E; Leung, H; Akhtar, N; Li, J; Barta, J R; Wang, Y; Yang, C; Kiarie, E

    2017-10-01

    Epidermal growth factor (EGF), a protein known for its mitogenic and anti-apoptotic effects was fed to broiler chickens to evaluate growth performance, gastrointestinal measurements, and apparent retention (AR) of components upon challenge with Eimeria. A total of 216, d old male broiler chicks (Ross 708) were placed in cages (6 birds/cage) and allocated to treatments. The treatments were: 1) control (Lactotobacilli lactis fermentation supernatant without EGF), 2) 80 μg of EGF/kg BW/d, and 3) 160 μg of EGF/kg BW/d. A basal antibiotic-free corn-soybean diet containing TiO2 was used. Birds were offered fresh feed with respective treatments on daily basis and had free access to drinking water for 14 d. On d 5, birds (6 replicates per treatment) were challenged with 1 mL of E. acervulina and E. maxima mixture via oral gavage and the other 6 replicates were given sham. Growth performance was measured in pre- (d 0 to 5) and post- (d 6 to 14) challenge periods. Two birds per cage were necropsied on d 10 for intestinal lesion scores and tissue samples for histomorphology and expression of select intestinal genes. Excreta samples for AR of components and oocyst shedding were taken d 10 to 13 and all birds were necropsied on d 14 for gastrointestinal weight. The EGF linearly (P Eimeria interaction (P > 0.05) on growth performance, AR of GE, and intestinal histomorphology; the main effects were such that Eimeria depressed (P Eimeria (P Eimeria challenged birds whilst no effect in non-challenged control. In conclusion, Eimeria challenge reduced growth performance and impaired gut function; EGF showed beneficial effects on growth pre-challenge and improved indices of gut function upon Eimeria challenge. © The Author 2017. Published by Oxford University Press on behalf of Poultry Science Association.

  2. Baseline placental growth factor levels for the prediction of benefit from early aspirin prophylaxis for preeclampsia prevention.

    Science.gov (United States)

    Moore, Gaea S; Allshouse, Amanda A; Winn, Virginia D; Galan, Henry L; Heyborne, Kent D

    2015-10-01

    Placental growth factor (PlGF) levels early in pregnancy are lower in women who ultimately develop preeclampsia. Early initiation of low-dose aspirin reduces preeclampsia risk in some high risk women. We hypothesized that low PlGF levels may identify women at increased risk for preeclampsia who would benefit from aspirin. Secondary analysis of the MFMU High-Risk Aspirin study including singleton pregnancies randomized to aspirin 60mg/d (n=102) or placebo (n=72), with PlGF collected at 13w 0d-16w 6d. Within the placebo group, we estimated the probability of preeclampsia by PlGF level using logistic regression analysis, then determined a potential PlGF threshold for preeclampsia prediction using ROC analysis. We performed logistic regression modeling for potential confounders. ROC analysis indicated 87.71pg/ml as the threshold between high and low PlGF for preeclampsia-prediction. Within the placebo group high PlGF weakly predicted preeclampsia (AUC 0.653, sensitivity/specificity 63%/66%). We noted a 2.6-fold reduction in preeclampsia with aspirin in the high-PlGF group (12.15% aspirin vs 32.14% placebo, p=0.057), but no significant differences in preeclampsia in the low PlGF group (21.74% vs 15.91%, p=0.445). Unlike other studies, we found that high rather than low PlGF levels were associated with an increased preeclampsia risk. Low PlGF neither identified women at increased risk of preeclampsia nor women who benefitted from aspirin. Further research is needed to determine whether aspirin is beneficial in women with high PlGF, and whether the paradigm linking low PlGF and preeclampsia needs to be reevaluated. High-risk women with low baseline PlGF, a risk factor for preeclampsia, did not benefit from early initiation of low-dose aspirin. Copyright © 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

  3. Effects of Family Functioning and Parenting Style on Early Entrants' Academic Performance and Program Completion

    Science.gov (United States)

    Huey, Erron L.; Sayler, Michael F.; Rinn, Anne N.

    2013-01-01

    The purpose of the current study was to examine the predictive nature of parenting style and overall family environment on the academic performance and program completion of early college entrants. Furthermore, gender and family form were examined as possible moderators to these relationships. A total of 88 early college entrants participated in…

  4. Archaeomagnetic Study performed on Early Medieval Buildings from western France

    Science.gov (United States)

    Chauvin, A.; Lanos, P.; Dufresne, P.; Blain, S.; Guibert, P.; Oberlin, C.; Sapin, C.

    2009-05-01

    A multiple dating study, involving a collaboration between specialists of dating techniques (thermoluminescence (TL) and radiocarbon), historians of art and archaeologists, has been carried out on several early medieval buildings from western France. The early medieval period is not well known especially in France where there is a lack of visible evidence that identifies pre-Romanesque architecture. The majority of buildings to have survived from this period are religious ones, considered important enough to be made of strong, non-perishable material such as stone or brick, as for example the churches of Notre-Dame-sous- Terre in the Mont-Saint-Michel or St Martin in Angers. Due to their significance in architectural history, it is imperative to position them accurately in the chronology of the history of art. Bricks are often used to build up round-headed arches or to reinforce the frame of a wall with bonding courses in those churches. TL dating and archeomagnetic analysis were performed on cores drilled within bricks while radiocarbon dating were undertaken on coals found within mortars. In order to increase the number of data during the early Middle Ages, archeointensity determinations using the classical Thellier technique with anisotropy of thermal remanence and cooling rate corrections were performed. Archaeomagnetic directions were used to recognize the firing position of bricsk during manufacture. Reliable and precise ages were obtained on the church Notre-Dame-sous-Terre; they indicate two phases of building in 950±50AD and 990±50AD. Mean archeointensities obtained on 17 (21) samples from the first (second) phases appears very closed 69.1±1.2 and 68.3±1.6 microTesla. Ages and archeomagnetic results obtained on 4 other sites will be presented and compared to the available data in western Europe.

  5. Weed Growth Stage Estimator Using Deep Convolutional Neural Networks

    DEFF Research Database (Denmark)

    Teimouri, Nima; Dyrmann, Mads; Nielsen, Per Rydahl

    2018-01-01

    conditions with regards to soil types, resolution and light settings. Then, 9649 of these images were used for training the computer, which automatically divided the weeds into nine growth classes. The performance of this proposed convolutional neural network approach was evaluated on a further set of 2516...... in estimating the number of leaves and 96% accuracy when accepting a deviation of two leaves. These results show that this new method of using deep convolutional neural networks has a relatively high ability to estimate early growth stages across a wide variety of weed species....

  6. Effects of strains on growth performances of triploid bighead catfish, Clarias macrocephalus Günther, 1864

    Directory of Open Access Journals (Sweden)

    Satid Chatchaiphan

    2016-07-01

    Full Text Available Despite its importance, limited empirical information is available on the effects of parental strains on the performance of triploid aquatic animals, especially of tropical species. The present study was conducted to evaluate the impacts of strains on the growth performance of the triploid bighead catfish (Clarias macrocephalus Günther, 1864 which was produced using cold shock (7 °C, 25 min shock duration, applied to newly fertilized eggs obtained from all possible crosses between two catfish strains. The fingerlings of each group were reared until they were age 240 d. At age 60 d, the triploid fish had a lower specific growth rate (SGR, absolute growth rate (AGR, body length and body weight than the diploid counterparts. However, at harvest (age 240 d body length and body weight were not different between the two groups while SGR of the cold shock group was higher than the diploid during age 121–240 d. The results revealed that parental strains did not show significant direct effects on the growth performance of triploids, but the interaction between paternal strain × shock was significant for the following traits: body length at age 90 d, body weight at age 90 d and 120 d, AGR for age 61–90 d, and SGR for age 61–90 d and 91–120 d. The interaction between paternal × maternal strain × shock was significant for body length, body weight at age 180 d and AGR for age 121–180 d. These results suggested that the growth performance of triploid C. macrocephalus cannot be enhanced by improving the parental strains; rather, improvement may be accomplished by selecting the parental strains based on triploid performance.

  7. Phonological and Non-Phonological Language Skills as Predictors of Early Reading Performance

    Science.gov (United States)

    Batson-Magnuson, LuAnn

    2010-01-01

    Accurate prediction of early childhood reading performance could help identify at-risk students, aid in the development of evidence-based intervention strategies, and further our theoretical understanding of reading development. This study assessed the validity of the Developmental Indicator for the Assessment of Learning (DIAL) language-based…

  8. The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain.

    Science.gov (United States)

    Peng, Y; Lu, Z; Li, G; Piechowicz, M; Anderson, M; Uddin, Y; Wu, J; Qiu, S

    2016-07-01

    The human MET gene imparts a replicated risk for autism spectrum disorder (ASD), and is implicated in the structural and functional integrity of brain. MET encodes a receptor tyrosine kinase, MET, which has a pleiotropic role in embryogenesis and modifies a large number of neurodevelopmental events. Very little is known, however, on how MET signaling engages distinct cellular events to collectively affect brain development in ASD-relevant disease domains. Here, we show that MET protein expression is dynamically regulated and compartmentalized in developing neurons. MET is heavily expressed in neuronal growth cones at early developmental stages and its activation engages small GTPase Cdc42 to promote neuronal growth, dendritic arborization and spine formation. Genetic ablation of MET signaling in mouse dorsal pallium leads to altered neuronal morphology indicative of early functional maturation. In contrast, prolonged activation of MET represses the formation and functional maturation of glutamatergic synapses. Moreover, manipulating MET signaling levels in vivo in the developing prefrontal projection neurons disrupts the local circuit connectivity made onto these neurons. Therefore, normal time-delimited MET signaling is critical in regulating the timing of neuronal growth, glutamatergic synapse maturation and cortical circuit function. Dysregulated MET signaling may lead to pathological changes in forebrain maturation and connectivity, and thus contribute to the emergence of neurological symptoms associated with ASD.

  9. Improved Performance in Mammalian Cell Perfusion Cultures by Growth Inhibition.

    Science.gov (United States)

    Wolf, Moritz K F; Closet, Aurélie; Bzowska, Monika; Bielser, Jean-Marc; Souquet, Jonathan; Broly, Hervé; Morbidelli, Massimo

    2018-05-21

    Mammalian cell perfusion cultures represent a promising alternative to the current fed-batch technology for the production of various biopharmaceuticals. Long-term operation at a fixed viable cell density (VCD) requires a viable culture and a constant removal of excessive cells. Product loss in the cell removing bleed stream deteriorates the process yield. In this study, the authors investigate the use of chemical and environmental growth inhibition on culture performance by either adding valeric acid (VA) to the production media or by reducing the culture temperature (33.0 °C) with respect to control conditions (36.5 °C, no VA). Low temperature significantly reduces cellular growth, thus, resulting in lower bleed rates accompanied by a reduced product loss of 11% compared to 26% under control conditions. Additionally, the cell specific productivity of the target protein improves and maintained stable leading to media savings per mass of product. VA shows initially an inhibitory effect on cellular growth. However, cells seemed to adapt to the presence of the inhibitor resulting in a recovery of the cellular growth. Cell cycle and Western blot analyses support the observed results. This work underlines the role of temperature as a key operating variable for the optimization of perfusion cultures. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Early Retirement Payoff

    Science.gov (United States)

    Fitzpatrick, Maria D.; Lovenheim, Michael F.

    2014-01-01

    As public budgets have grown tighter over the past decade, states and school districts have sought ways to control the growth of spending. One increasingly common strategy employed to rein in costs is to offer experienced teachers with high salaries financial incentives to retire early. Although early retirement incentive (ERI) programs have been…

  11. Growth Performance Of Mono-Sex And Mixed Sex Population Of ...

    African Journals Online (AJOL)

    The growth performance of all-male, all-female and mixed sex population of Oreochromis niloticus fed similar diet was carried out. The fingerlings used in the study were of relatively similar weight ranges (24.8 g – 26.6 g) with initial mean weight of 25.7±1.3 g and initial mean total length of 3.8 ± 1.5 cm. The mean increase ...

  12. Early changes in plasma glucagon and growth hormone response to oral glucose in experimental hyperthyroidism.

    Science.gov (United States)

    Tosi, F; Moghetti, P; Castello, R; Negri, C; Bonora, E; Muggeo, M

    1996-08-01

    The mechanisms underlying deterioration of glucose tolerance associated with hyperthyroidism are not completely understood. Increases in glucagon and growth hormone (GH) secretion have been previously found in hyperthyroid subjects, and could play a crucial role in this phenomenon. However, studies have not yet established the time sequence of changes in plasma glucose on the one hand and glucagon and GH on the other. To assess the early effects of thyroid hormone excess on glucose tolerance and plasma concentrations of the main glucoregulatory hormones, 12 nondiabetic euthyroid subjects underwent an oral glucose tolerance test (OGTT) before and after triiodothyronine ([T3] 120 micrograms/d) was administered for 10 days. Plasma levels of glucose, insulin, glucagon, and GH were determined at fasting and after the glucose load. T3 administration caused a marked increase in serum T3 (8.8 +/- 0.6 v 2.0 +/- 0.1 nmol/L), with clinical and biochemical signs of thyrotoxicosis. During the treatment, plasma glucose significantly increased both at fasting and after the glucose load (basal, 5.3 +/- 0.1 v 4.9 +/- 0.2 mmol/L, P hormone excess rapidly impairs glucose tolerance. Altered secretion of GH is an early event in thyrotoxicosis accompanying the onset of hyperglycemia, whereas plasma glucagon is appropriately suppressed by the increased plasma glucose levels. Thus, GH but not glucagon may contribute to the early hyperglycemic effect of thyrotoxicosis.

  13. Short communication. Effect of soybean meal heat procedures on growth performance of broiler chickens

    Energy Technology Data Exchange (ETDEWEB)

    Tousi-Mojarradi, M.; Seidavi, A.; Dadashbeiki, M.; Roca-Fernandez, A. I.

    2014-06-01

    The aim of this research was to study the effect of soybean meal (SBM) heat procedures on growth performance of broiler chickens. A trial was carried out using 200 male Ross 308 strain chickens during 3 feeding periods (starter, grower and finisher, 42 days). The experiment was based on a completely randomized design with 5 treatments giving 4 replications of 10 broilers per treatment. Treatments consisted on: T1 (control, un-processed SBM), T2 (autoclaved SBM: 121 degree centigrade, 20 min), T3 (autoclaved SBM: 121 degree centigrade, 30 min), T4 (roasted SBM: 120 degree centigrade, 20 min) and T5 (microwaved SBM: 46 degree centigrade, 540 watt, 7 min). Growth performance of animals was examined by determining body weight (BW), body weight grain (BWG), feed intake (FI) and feed conversion rate (FCR). Higher BW (p<0.05) and BWG (p<0.05) and lower FCR (p<0.05) were found in broiler chickens fed heat processed SBM diets compared to those fed a raw SBM diet, probably due to higher nutrient availability. However, no differences were found among heat SBM procedures (autoclaving, roasting and microwaving) on growth performance of animals for the starter, grower and finisher periods. From the results of this experiment, it is concluded that further research needs to be developed to establish the effect of temperature-time heat procedures on nutritive value of SBM in terms of levels of anti-nutritional factors (trypsin inhibitor activity and phytic acid) and amino acids profile and its influence on growth performance of broilers. (Author)

  14. Jimma Town: Foundation and Early Growth from ca. 1830 to 1936

    Directory of Open Access Journals (Sweden)

    Seifu Yonas

    2017-12-01

    Full Text Available This study deals with the early history of Jimma town and its growth from its foundation until 1936. It explores social, economic and administrative themes, but also attempts to show the interrelationship between these themes. The town of Jimma evolved during this period from being the home-town of a relatively homogenous society and culture into a place of residence for a diverse and increasingly cosmopolitan population. Economically, the story of Jimma during this period is one of both continuity and change. It is a story of continuity because Jimma, which had been a center of trade from the very beginning, continued to be so during this period. There was significant change, however, because unlike the previous decades in which Jimma had served as a point of exchange or transit for elite goods that mostly originated from beyond the borders of the Oromo Kingdom (such as slaves, ivory and musk, during this period the town developed into the chief center for the collection, organization and export of a cash crop that was grown locally (coffee.

  15. [Construction of individual-based ecological model for Scomber japonicas at its early growth stages in East China Sea].

    Science.gov (United States)

    Li, Yue-Song; Chen, Xin-Jun; Yang, Hong

    2012-06-01

    By adopting FVCOM-simulated 3-D physical field and based on the biological processes of chub mackerel (Scomber japonicas) in its early life history from the individual-based biological model, the individual-based ecological model for S. japonicas at its early growth stages in the East China Sea was constructed through coupling the physical field in March-July with the biological model by the method of Lagrange particle tracking. The model constructed could well simulate the transport process and abundance distribution of S. japonicas eggs and larvae. The Taiwan Warm Current, Kuroshio, and Tsushima Strait Warm Current directly affected the transport process and distribution of the eggs and larvae, and indirectly affected the growth and survive of the eggs and larvae through the transport to the nursery grounds with different water temperature and foods. The spawning grounds in southern East China Sea made more contributions to the recruitment to the fishing grounds in northeast East China Sea, but less to the Yangtze estuary and Zhoushan Island. The northwestern and southwestern parts of spawning grounds had strong connectivity with the nursery grounds of Cheju and Tsushima Straits, whereas the northeastern and southeastern parts of the spawning ground had strong connectivity with the nursery grounds of Kyushu and Pacific Ocean.

  16. The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories.

    Science.gov (United States)

    Wu, Yan Yan; Lye, Stephen; Briollais, Laurent

    2017-10-01

    Recent studies have implicated the FTO gene in child and adult obesity. A longer duration of exclusive breastfeeding (EXBF) has been shown to reduce body mass index (BMI) and the risk of being overweight in the general population and among FTO gene carriers. However, it remains unclear whether the preventive effect of EXBF could be explained by its impact on early life growth development, e.g. ages at adiposity peak (AP) and adiposity rebound (AR) and BMI velocities in the first years of life, which are major determinants of overweight and obesity later in life. We studied 5590 children from the British Avon Longitudinal Study of Parents and Children (ALSPAC) cohort and modelled their longitudinal BMI profiles with mixed effects models from birth to 16 years of age, as well as their ages at AP, AR and BMI velocities in relation to the FTO gene variant and EXBF. A longer duration of EXBF (i.e. at least 5 months) has substantial impact on BMI growth trajectories among children carrying the FTO adverse variant by modulating the age at AP, age at AR and BMI velocities. EXBF acts antagonistically to the FTO rs9939609 risk allele and by the age of 15, the predicted reduction in BMI after 5 months of EXBF is 0.56 kg/m2 [95% confidence interval (CI) 0.11-1.01; P = 0.003] and 1.14 kg/m2 (95% CI 0.67-1.62; P < 0.0001) in boys and girls, respectively. EXBF influences early life growth development and thus plays a critical role in preventing the risks of overweight and obesity even when those are exacerbated by genetic factors. © The Author 2017; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association

  17. Effects of site preparation treatments on early growth and survival of planted longleaf pine (Pinus palustris Mill.) seedlings in North Carolina

    Science.gov (United States)

    Benjamin O. Knapp; G. Geoff Wang; Joan L. Walker; Susan Cohen

    2006-01-01

    We tested the effects of eight site preparation treatments on early growth and survival of container-grown longleaf pine (Pinus palustris Mill.) seedlings. Treatments included an untreated check, six combinations of two initial vegetation control treatments (chopping or herbicide) with three planting site conditions (flat [no additional treatment],...

  18. Association of malignancy with rapid growth in early lesions induced by irradiation of rat skin

    International Nuclear Information System (INIS)

    McGregor, J.F.

    1979-01-01

    Epithelial lesions induced by irradiation of rat skin were studied to determine (a) the relationship of malignancy to dose, (b) the types of lesions and circumstances leading to overt malignancy, and (c) the growth rates of lesions progressing to malignancy versus those of lesions remaining benign. High doses of radiation were shown to be associated with the production of epidermal cancers, the maximum yield being obtained at 6,400 rads. Conversely, a peak yield of noncancerous lesions was obtained at 1,600 rads. This association between malignancy and high dose was consistent for cancers evolving from warts, cysts, and chronic ulcers. Although the proportion of warts among the induced lesions was much higher than that of the cysts or chronic ulcers (76, 14, and 10%, respectively), the likelihood of warts becoming cancerous was substantially lower (14, 23, and 21%). The combined data for all doses showed that the latency period of the epidermal cancers was significantly (P = 0.015) shorter than that of the benign tumors. Rapid growth rates were observed for warts, cysts, and chronic ulcers progressing to overt cancer, and these did not overlap at any point on the growth scale with rates for benign tumors. This finding suggested that the potential for malignant development had been established early in the carcinogenic process, very likely at induction

  19. Overweight among Four-Year-Old Children in Relation to Early Growth Characteristics and Socioeconomic Factors

    Directory of Open Access Journals (Sweden)

    Jörgen Thorn

    2010-01-01

    Full Text Available Objectives. To assess early growth characteristics and socioeconomic factors of children in relation to body mass index (BMI and presence of overweight among four-year-old children. Methods. Two Child Health Centres (CHC participated in the study. They were selected to obtain two populations of children featuring divergent socio-economic characteristics. Growth data registered at the CHCs from birth to the 4-year check-up were recovered. Overweight was defined by the BMI cut-offs established by IOTF. BMI values expressed as BMI standard deviation score (BMISDS were used for analysis. Results. At the 4-year check-up, the BMISDS and the proportion of children with overweight (including the obese were significantly higher in the district with lower socio-economic status. High BMI at birth and low socio-economic status of the population in the CHC-district were shown to be independent determinants for overweight and BMISDS at four years of age. Conclusions. More research is needed to understand the mechanisms and how intervention programs should be designed in order to prevent the development of overweight and obesity in children.

  20. Constant and alternating temperature effects on germination and early growth of scorzonera

    OpenAIRE

    Dias, A.S.; Dias, L.S.; Pereira, I.P.

    2013-01-01

    Scorzonera is a threatened species in Portugal. Given the role of temperature in germination and seedling recruitment, the performance of total germination, lag of germination, duration of germination, shape of germination, root and hypocotyl length, and relative root growth of scorzonera was investigated under constant and alternating temperatures between 10 and 25ºC. Because of scorzonera’s rarity and threatened status, seeds of cultivated scorzonera were used, providing the framework for h...

  1. Artificially regenerating longleaf pine on wet sites: preliminary analysis of effects of site preparation treatments on early survival and growth

    Science.gov (United States)

    Benjamin O. Knapp; G. Geoff Wang; Joan L. Walker

    2010-01-01

    Our study, conducted over two years on poorly drained, sandy sites in Onslow County, NC, compared the effects of eight common site preparation treatments on early survival and growth of planted longleaf pine seedlings. Through two growing seasons, we found survival to be similar across all treatments (p = 0.8806), but root collar diameter was greatest with combinations...

  2. Is Intelligence in Early Adulthood Associated With Midlife Physical Performance among Danish Males?

    DEFF Research Database (Denmark)

    Osler, Merete; Meincke, Rikke Hodal; Mortensen, Erik Lykke

    2016-01-01

    Objective: Insights into the causes of variances in physical performance are important to prevent mobility limitations in old age. We examined associations between intelligence in early adulthood and midlife physical performance. Method: Data from the Copenhagen Aging and Midlife Biobank were...... analyzed using linear regression. In total, 2,848 male cohort members had intelligence scores from conscription and physical performance measures from midlife. Results: In adjusted models, a 1 SD increase in intelligence resulted in 1.10 more chair-rises (p

  3. Contributions of Motivation, Early Numeracy Skills, and Executive Functioning to Mathematical Performance. A Longitudinal Study.

    Science.gov (United States)

    Mercader, Jessica; Miranda, Ana; Presentación, M Jesús; Siegenthaler, Rebeca; Rosel, Jesús F

    2017-01-01

    The main goal of this longitudinal study is to examine the power of different variables and its dynamic interactions in predicting mathematical performance. The model proposed in this study includes indicators of motivational constructs (learning motivation and attributions), executive functioning (inhibition and working memory), and early numeracy skills (logical operations, counting, and magnitude comparison abilities), assessed during kindergarten, and mathematical performance in the second year of Primary Education. The sample consisted of 180 subjects assessed in two moments (5-6 and 7-8 years old). The results showed an indirect effect of initial motivation on later mathematical performance. Executive functioning and early numeracy skills mediated the effect of motivation on later mathematic achievement. Practical implications of these findings for mathematics education are discussed.

  4. Effect of acorn mass and size, and early shoot growth on one-year old container-grown RPM™ oak seedlings

    Science.gov (United States)

    Benjamin C. Grossman; Michael A. Gold; Daniel C. Dey

    2003-01-01

    The purpose of this study was to evaluate the influence of seed source, acorn mass and size, and early shoot growth on morphological traits of 1-year-old oak seedlings. Forested bottomlands in the Midwest have been greatly reduced in the past 150 years as a result of conversion to agriculture and recent catastrophic floods. Due to a lack of available hard mast, intense...

  5. Effects of ractopamine hydrochloride on growth performance and carcass characteristics in wool and hair lambs

    Directory of Open Access Journals (Sweden)

    Ángel M. Romero-Maya

    2013-06-01

    Full Text Available This study aimed at evaluating the effects of ractopamine hydrochloride (RAC on growth performance and carcass characteristics of wool and hair lambs. For this purpose, 48 lambs averaging 31.3 kg body weight, of which twenty were wool (Ramboullet x Suffolk and twenty eight were hair (Tabasco lambs, and four levels of RAC (0, 10, 20, and 30 mg/kg diet, dry matter basis were used. Wool lambs fed 20 and 30 mg RAC had higher (P<0.05 total gain weight and lower feed conversion than 0 and 10 mg RAC. Wool lambs fed 20 mg RAC had the highest carcass weight, dressing, legs weight and longissimus area as compared to 0, 10 and 30 mg RAC.  In hair lambs there were not effect of RAC on growth performance and carcass characteristics.It was concluded that addition of RAC to finishing diets offered the best growth performance and carcass traits in wool lambs as compared to hair lambs. 

  6. The Growth of Small Corrosion Fatigue Cracks in Alloy 7075

    Science.gov (United States)

    Piascik, Robert S.

    2015-01-01

    The corrosion fatigue crack growth characteristics of small (greater than 35 micrometers) surface and corner cracks in aluminum alloy 7075 is established. The early stage of crack growth is studied by performing in situ long focal length microscope (500×) crack length measurements in laboratory air and 1% sodium chloride (NaCl) environments. To quantify the "small crack effect" in the corrosive environment, the corrosion fatigue crack propagation behavior of small cracks is compared to long through-the-thickness cracks grown under identical experimental conditions. In salt water, long crack constant K(sub max) growth rates are similar to small crack da/dN.

  7. Only 7% of the variation in feed efficiency in veal calves can be predicted from variation in feeding motivation, digestion, metabolism, immunology, and behavioral traits in early life

    NARCIS (Netherlands)

    Gilbert, M.S.; Borne, van den J.J.G.C.; Reenen, van C.G.; Gerrits, W.J.J.

    2017-01-01

    High interindividual variation in growth performance is commonly observed in veal calf production and appears to depend on milk replacer (MR) composition. Our first objective was to examine whether variation in growth performance in healthy veal calves can be predicted from early life

  8. Effect of the Nerve Growth Factor Mimetic GK-2 on Brain Structural and Functional State in the Early Postresuscitation Period

    Directory of Open Access Journals (Sweden)

    M. Sh. Avrushchenko

    2012-01-01

    Full Text Available Objective: to evaluate the efficacy of the nerve growth factor mimetic GK-2 used to improve the structural and functional state of the brain in the early postresuscitation period. Material and methods. Cardiac arrest was induced in mature male albino rats for 12 minutes, followed by resuscitation. The neurological state of the resuscitated animals was assessed by a scoring scale. On postresuscitation day 7, the density and composition of neuronal populations of Purkinje cells in the lateral cerebellar region and pyramidal neurons in the hippocampal CA1 sector were determined by a differential morphometric analysis. The results were statistically processed using the ANOVA method. Results. The use of GK-2 was found to accelerate neurological recovery in the resuscitated animals. On day 7 after 12-minute cardiac arrest, the resuscitated animals showed neuronal dystrophic changes and death in the neuronal populations highly susceptible to ischemia. It was shown that the systemic administration of the nerve growth factor mimetic GK-2 contributed to a reduction in the magnitude and depth of postresuscitation changes in the cerebellar Purkinje cells and prevented dystrophic changes in the pyramidal cells of the hippocampal CA1 sector. The findings suggest that GK-2 has a neuroprotective effect in the recovery period after total body ischemia. Conclusion. The results of this study indicate the efficiency of the systemic administration of the nerve growth factor mimetic GK-2 in improving the brain structural and functional state in the early postresuscitation period. This determines perspectives for the use of GK-2 to prevent and correct posthypoxic encephalopathies. Key words: the nerve growth factor mimetic GK-2, postresuscitation period, neuronal dystrophic changes and death, neurological status.

  9. Hydrogen Storage Needs for Early Motive Fuel Cell Markets

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, J.; Ainscough, C.; Simpson, L.; Caton, M.

    2012-11-01

    The National Renewable Energy Laboratory's (NREL) objective for this project is to identify performance needs for onboard energy storage of early motive fuel cell markets by working with end users, manufacturers, and experts. The performance needs analysis is combined with a hydrogen storage technology gap analysis to provide the U.S. Department of Energy (DOE) Fuel Cell Technologies Program with information about the needs and gaps that can be used to focus research and development activities that are capable of supporting market growth.

  10. Early executive function predicts reasoning development.

    Science.gov (United States)

    Richland, Lindsey E; Burchinal, Margaret R

    2013-01-01

    Analogical reasoning is a core cognitive skill that distinguishes humans from all other species and contributes to general fluid intelligence, creativity, and adaptive learning capacities. Yet its origins are not well understood. In the study reported here, we analyzed large-scale longitudinal data from the Study of Early Child Care and Youth Development to test predictors of growth in analogical-reasoning skill from third grade to adolescence. Our results suggest an integrative resolution to the theoretical debate regarding contributory factors arising from smaller-scale, cross-sectional experiments on analogy development. Children with greater executive-function skills (both composite and inhibitory control) and vocabulary knowledge in early elementary school displayed higher scores on a verbal analogies task at age 15 years, even after adjusting for key covariates. We posit that knowledge is a prerequisite to analogy performance, but strong executive-functioning resources during early childhood are related to long-term gains in fundamental reasoning skills.

  11. Early functional and morphological brain disturbances in late-onset intrauterine growth restriction.

    Science.gov (United States)

    Starčević, Mirta; Predojević, Maja; Butorac, Dražan; Tumbri, Jasna; Konjevoda, Paško; Kadić, Aida Salihagić

    2016-02-01

    To determine whether the brain disturbances develop in late-onset intrauterine growth restriction (IUGR) before blood flow redistribution towards the fetal brain (detected by Doppler measurements in the middle cerebral artery and umbilical artery). Further, to evaluate predictive values of Doppler arterial indices and umbilical cord blood gases and pH for early functional and/or morphological brain disturbances in late-onset IUGR. This cohort study included 60 singleton term pregnancies with placental insufficiency caused late-onset IUGR (IUGR occurring after 34 gestational weeks). Umbilical artery resistance index (URI), middle cerebral artery resistance index (CRI), and cerebroumbilical (C/U) ratio (CRI/URI) were monitored once weekly. Umbilical blood cord samples (arterial and venous) were collected for the analysis of pO2, pCO2 and pH. Morphological neurological outcome was evaluated by cranial ultrasound (cUS), whereas functional neurological outcome by Amiel-Tison Neurological Assessment at Term (ATNAT). 50 fetuses had C/U ratio>1, and 10 had C/U ratio≤1; among these 10 fetuses, 9 had abnormal neonatal cUS findings and all 10 had non-optimal ATNAT. However, the total number of abnormal neurological findings was much higher. 32 neonates had abnormal cUS (53.37%), and 42 (70.00%) had non-optimal ATNAT. Furthermore, Doppler indices had higher predictive validity for early brain disturbances than umbilical cord blood gases and pH. C/U ratio had the highest predictive validity with threshold for adverse neurological outcome at value 1.13 (ROC analysis), i.e., 1.18 (party machine learning algorithm). Adverse neurological outcome at average values of C/U ratios>1 confirmed that early functional and/or structural brain disturbances in late-onset IUGR develop even before activation of fetal cardiovascular compensatory mechanisms, i.e., before Doppler signs of blood flow redistribution between the fetal brain and the placenta. Copyright © 2015 Elsevier Ireland Ltd

  12. Dietary inclusion of direct fed microbe on the growth performance of ...

    African Journals Online (AJOL)

    The birds were obtained from a reputable hatchery and randomly assigned to four dietary treatments, each with three replicate of ten birds. ... The results show that the growth performance of the broiler chicken fed diet containing different level of direct fed microbes did not differ significantly (P>0.05) in initial weight, final ...

  13. Growth performance and gastrointestinal responses of broiler chickens fed corn-soybean meal diet without or with exogenous epidermal growth factor upon challenge with Eimeria1

    Science.gov (United States)

    Kim, E.; Leung, H.; Akhtar, N.; Li, J.; Barta, J. R.; Wang, Y.; Yang, C.; Kiarie, E.

    2017-01-01

    Abstract Epidermal growth factor (EGF), a protein known for its mitogenic and anti-apoptotic effects was fed to broiler chickens to evaluate growth performance, gastrointestinal measurements, and apparent retention (AR) of components upon challenge with Eimeria. A total of 216, d old male broiler chicks (Ross 708) were placed in cages (6 birds/cage) and allocated to treatments. The treatments were: 1) control (Lactotobacilli lactis fermentation supernatant without EGF), 2) 80 μg of EGF/kg BW/d, and 3) 160 μg of EGF/kg BW/d. A basal antibiotic-free corn-soybean diet containing TiO2 was used. Birds were offered fresh feed with respective treatments on daily basis and had free access to drinking water for 14 d. On d 5, birds (6 replicates per treatment) were challenged with 1 mL of E. acervulina and E. maxima mixture via oral gavage and the other 6 replicates were given sham. Growth performance was measured in pre- (d 0 to 5) and post- (d 6 to 14) challenge periods. Two birds per cage were necropsied on d 10 for intestinal lesion scores and tissue samples for histomorphology and expression of select intestinal genes. Excreta samples for AR of components and oocyst shedding were taken d 10 to 13 and all birds were necropsied on d 14 for gastrointestinal weight. The EGF linearly (P Eimeria interaction (P > 0.05) on growth performance, AR of GE, and intestinal histomorphology; the main effects were such that Eimeria depressed (P Eimeria (P Eimeria challenged birds whilst no effect in non-challenged control. In conclusion, Eimeria challenge reduced growth performance and impaired gut function; EGF showed beneficial effects on growth pre-challenge and improved indices of gut function upon Eimeria challenge. PMID:28938785

  14. Influence of dietary nonstructural carbohydrate concentration on growth performance and carcass characteristics of Holstein steers.

    Science.gov (United States)

    Ramos-Aviña, Daniel; Plascencia, Alejandro; Zinn, Richard

    2018-06-01

    Since very little information exists about the topic; in this experiment we compare, in a long-term finishing program, the growth-performance responses and carcass characteristics of Holstein steers where non-structural carbohydrate concentration of the diet is reduced from 64% to 51% (dry matter basis). Sixty Holstein steer calves (129±2.2 kg) were blocked by initial weight into five groups and randomly assigned within weight groupings to 10 pens. Calves were fed with a steam-flaked corn-based finishing diets containing 51% higher fiber (HF) or 64% lower fiber (LF) nonstructural carbohydrates. Non-structural carbohydrates concentrations were manipulated substituting dried distiller grain with solubles and alfalfa hay for flaked corn. Cattle were weighed every 112 days and at the end of the experiment (day 308) when the cattle were harvested and carcass characteristics were evaluated. Steers fed the HF diet showed improvement (8.8%) in average daily gain (ADG) during the initial 112-d period. This effect was followed by a numerical trend for greater ADG throughout the remainder of the study so that overall ADG tended to be greater (4.9%, p = 0.06) for the HF than for LF. There were no treatment effects on dry matter intake. Gain efficiency and estimated dietary net energy (NE) were greater 8.3% and 5.2%, respectively for HF during the initial 112-d period. Overall (308-d) gain efficiency and estimated dietary NE were similar for both dietary treatments. However, due to differences in tabular dietary NE, the ratio of observed:expected dietary NE tended to be greater (4.1%, p = 0.06) for the HF vs LF diet. There were no treatment effects on carcass characteristics except for a tendency toward a slightly greater (0.5%, p = 0.09) estimated carcass yield. Reducing the non-structural carbohydrate concentration of a conventional steam-flaked corn-based growing finishing diet for Holstein steers can effectively enhance growth performance, particularly during the early

  15. A Longitudinal Examination of the Effects of Computer Self-efficacy Growth on Performance during Technology Training

    Directory of Open Access Journals (Sweden)

    James P. Downey

    2015-02-01

    Full Text Available Technology training in the classroom is critical in preparing students for upper level classes as well as professional careers, especially in fields such as technology. One of the key enablers to this process is computer self-efficacy (CSE, which has an extensive stream of empirical research. Despite this, one of the missing pieces is how CSE actually changes during training, and how such change is related to antecedents and performance outcomes. Measuring change requires repeated data gathering and the use of latent growth modeling, a relatively new statistical technique. This study examines CSE (specifically general CSE or GCSE growth over time during training, and how this growth is influenced by anxiety and gender and influences performance, using a semester-long lab course covering three applications. The use of GCSE growth more accurately models how students actually learn in a technology classroom. It provides novel clarity in the interaction of gender, anxiety, GCSE, specific CSEs, and performance during training. The study finds that the relationship between anxiety and self-efficacy decreases over time during training, becoming non-significant; it clarifies the significant role gender plays in influencing GCSE at the start of and during training. It finds GCSE influences application performance only through specific CSEs.

  16. Birth weight and postnatal growth in preterm born children are associated with cortisol in early infancy, but not at age 8 years.

    Science.gov (United States)

    Ruys, Charlotte A; van der Voorn, Bibian; Lafeber, Harrie N; van de Lagemaat, Monique; Rotteveel, Joost; Finken, Martijn J J

    2017-08-01

    Preterm birth has been associated with altered hypothalamic-pituitary-adrenal (HPA-) axis activity as well as cardiometabolic diseases and neurodevelopmental impairments later in life. We assessed cortisol from term age to age 8 y in children born preterm, to explore the development of HPA-axis activity in association with intrauterine and early-postnatal growth until 6 mo. corrected age. In 152 children born at a gestational age ≤32 wks. and/or with a birth weight ≤1,500g, random serum cortisol was assessed at term age (n=150), 3 mo. (n=145) and 6 mo. corrected age (n=144), and age 8 y (n=59). Salivary cortisol was assessed at age 8 y (n=75): prior to bedtime, at awakening, 15min after awakening, and before lunch. Cortisol was analyzed in association with birth weight-standard deviation score (SDS), being born small for gestational age (SGA), and combinations of intrauterine and postnatal growth: appropriate for gestational age (AGA) with or without growth restriction (AGA GR+ or AGA GR-) at 6 mo. corrected age, and SGA with or without catch-up growth (SGA CUG+ or SGA CUG-) at 6 mo. corrected age. Cross-sectional associations at all time points were analyzed using linear regression, and longitudinal associations were analyzed using generalized estimating equations. Longitudinally, birth weight-SDS was associated with cortisol (β [95%CI]): lower cortisol over time was seen in infants with a birth weight ≤-2 SDS (-50.69 [-94.27; -7.11], p=0.02), infants born SGA (-29.70 [-60.58; 1.19], p=0.06), AGA GR+ infants (-55.10 [-106.02; -4.17], p=0.03) and SGA CUG- infants (-61.91 [-104.73; -19.10], p=0.01). In cross-sectional analyses at age 8 y, no associations were found between either serum or salivary cortisol and birth weight-SDS, SGA-status, or growth from birth to 6 mo. corrected age. In children born preterm, poor intrauterine and postnatal growth were associated with lower cortisol in early infancy, but not at age 8 y. Even though HPA-axis activity no longer

  17. Effects of pig antibacterial peptides on growth performance and intestine mucosal immune of broiler chickens.

    Science.gov (United States)

    Bao, H; She, R; Liu, T; Zhang, Y; Peng, K S; Luo, D; Yue, Z; Ding, Y; Hu, Y; Liu, W; Zhai, L

    2009-02-01

    Currently, substitutions for antibiotic growth promoters in animals are attracting interest. This study investigated the effects of pig antibacterial peptides (PABP) on growth performance and small intestine mucosal immune responses in broilers. Three hundred 1-d-old Arbor Acre male broiler chickens were randomly allocated to 5 groups with 60 birds per group. The groups were control group; PABP administered in drinking water at 20 and 30 mg/L of water; or PABP supplemented in feed at 150 and 200 mg/kg of diet. The birds were fed a corn-soybean based diet for 6 wk. Chickens were weighed weekly and killed after 42 d of feeding, and growth performance was measured. Samples of the duodenum and jejunum were collected. The villus height, mucosa thickness, alkaline phosphatase activity, and numbers of secreting IgA and goblet cells were evaluated. The PABP-treated groups had greater BW and average daily gain, greater height of villus and thickness of gut mucosa, greater activity of alkaline phosphatase, higher ratio of secreting IgA, and a greater number of goblet cells compared with the control group (P<0.05). In conclusion, PABP can improve the growth performance, increase the intestinal ability to absorb nutrients, and improve the mucosal immunity of the intestine.

  18. Low maternal education is associated with increased growth velocity in the first year of life and in early childhood: the ABCD study

    NARCIS (Netherlands)

    van den Berg, Gerrit; van Eijsden, Manon; Galindo-Garre, Francisca; Vrijkotte, Tanja; Gemke, Reinoud

    2013-01-01

    The objective of this study is first to examine the relation of maternal education and growth velocity during the first year of life and early childhood (1-5 years). The second objective is to determine the potential explanatory role of standardized birth weight, maternal smoking during pregnancy,

  19. Contributions of Motivation, Early Numeracy Skills, and Executive Functioning to Mathematical Performance. A Longitudinal Study

    Directory of Open Access Journals (Sweden)

    Jessica Mercader

    2018-01-01

    Full Text Available The main goal of this longitudinal study is to examine the power of different variables and its dynamic interactions in predicting mathematical performance. The model proposed in this study includes indicators of motivational constructs (learning motivation and attributions, executive functioning (inhibition and working memory, and early numeracy skills (logical operations, counting, and magnitude comparison abilities, assessed during kindergarten, and mathematical performance in the second year of Primary Education. The sample consisted of 180 subjects assessed in two moments (5–6 and 7–8 years old. The results showed an indirect effect of initial motivation on later mathematical performance. Executive functioning and early numeracy skills mediated the effect of motivation on later mathematic achievement. Practical implications of these findings for mathematics education are discussed.

  20. A community-based study of early childhood sensory stimulation in home environment associated with growth and psychomotor development in Pakistan.

    Science.gov (United States)

    Avan, Bilal Iqbal; Raza, Syed Ahsan; Kirkwood, Betty R

    2014-10-01

    Sensory stimulation (SS) is a non-nutritional modifiable risk factor for early childhood development. We assessed SS in home environment and examined its influence on physical growth and psychomotor development (PD). A cross-sectional study was conducted in 26 communities in Pakistan among children aged development. There is a need to corroborate these results by additional research for integration in health policy initiatives.

  1. Early inflammatory response in epithelial ovarian tumor cyst fluids

    International Nuclear Information System (INIS)

    Kristjánsdóttir, Björg; Partheen, Karolina; Fung, Eric T; Yip, Christine; Levan, Kristina; Sundfeldt, Karin

    2014-01-01

    Mortality rates for epithelial ovarian cancer (EOC) are high, mainly due to late-stage diagnosis. The identification of biomarkers for this cancer could contribute to earlier diagnosis and increased survival rates. Given that chronic inflammation plays a central role in cancer initiation and progression, we selected and tested 15 cancer-related cytokines and growth factors in 38 ovarian cyst fluid samples. We used ovarian cyst fluid since it is found in proximity to the pathology and mined it for inflammatory biomarkers suitable for early detection of EOC. Immunoprecipitation and high-throughput sample fractionation were obtained by using tandem antibody libraries bead and mass spectrometry. Two proteins, monocyte chemoattractant protein-1 (MCP-1/CCL2) and interleucin-8 (IL-8/CXCL8), were significantly (P < 0.0001) higher in the malignant (n = 16) versus benign (n = 22) tumor cysts. Validation of MCP-1, IL-8, and growth-regulated protein-α (GROα/CXCL1) was performed with ELISA in benign, borderline, and malignant cyst fluids (n = 256) and corresponding serum (n = 256). CA125 was measured in serum from all patients and used in the algorithms performed. MCP-1, IL-8, and GROα are proinflammatory cytokines and promoters of tumor growth. From 5- to 100-fold higher concentrations of MCP-1, IL-8 and GROα were detected in the cyst fluids compared to the serum. Significant (P < 0.001) cytokine response was already established in borderline cyst fluids and stage I EOC. In serum a significant (P < 0.01) increase of IL-8 and GROα was found, but not until stage I and stage III EOC, respectively. These findings confirm that early events in tumorigenesis can be analyzed and detected in the tumor environment and we conclude that ovarian cyst fluid is a promising source in the search for new biomarkers for early ovarian tumors

  2. Early diet, insulin-like growth factor-1, growth and later obesity

    DEFF Research Database (Denmark)

    Michaelsen, Kim F; Larnkjær, Anni; Mølgaard, Christian

    2013-01-01

    to protect against obesity. A few studies have also suggested that early introduction of complementary foods (before age 4 months) is associated with an increased risk of later obesity. A high weight gain during early life, especially the first 6 months, is associated with a higher risk of developing obesity....... Breastfeeding has been shown to reduce the risk of later obesity, although the effect is not substantial. Complementary feeding also seems to play a role. There is some evidence that a high protein intake is associated with a higher risk of obesity later in childhood, whereas a high fat intake during...... the complementary feeding period does not seem to be a risk factor for later obesity. Thus, the dietary pattern during this period is different from the pattern seen in older children and adults where a high fat intake is associated with a higher risk of obesity and a high protein intake in some studies seems...

  3. Supercapacitor electrodes by direct growth of multi-walled carbon nanotubes on Al: a study of performance versus layer growth evolution

    International Nuclear Information System (INIS)

    Zhao, Fu; Vicenzo, Antonello; Hashempour, Mazdak; Bestetti, Massimiliano

    2014-01-01

    Supercapacitor electrodes were fabricated by direct growth of multi-walled carbon nanotubes (CNTs) on Al current collectors via a chemical vapor deposition process in the presence of a spin-coated Co-Mo catalyst. A detailed study of the dependence of the CNT layer structure and thickness on growth time set the basis for the assessment of supercapacitors assembled with the CNTs/Al electrodes. As the main features of the layer growth evolution, an increase in the population of finer CNTs and a shift from a random entanglement to a rough vertical alignment of nanotubes were noted with proceeding growth. The growth time influence on the performance of supercapacitors was in fact apparent. Particularly, the specific capacitance of CNTs/Al electrodes in 0.5 M K 2 SO 4 aqueous electrolyte increased from 35 to 80 F g −1 as the CNT layer thickness varied from 20 to 60 μm, with a concurrent loss in rate capability (knee frequency from 1 kHz to 60 Hz). The latter was excellent in general, arguably due to both a fast ion transport through the interconnected CNT network and a negligible contribution of the active layer/current collector contact to the equivalent series resistance (0.15–0.22 mΩ g), a distinct advantage of the direct growth fabrication method. Overall, a relatively simple process of direct growth of CNTs on Al foils is shown to be an effective method to fabricate supercapacitor electrodes, notably in the absence of special measures and processing steps finalized to a tight control of nanotubes growth and organization

  4. Effects of Salinity on the Habitat Selection and Growth Performance of Mediterranean Flathead Grey Mullet Mugil cephalus (Osteichthyes, Mugilidae)

    Science.gov (United States)

    Cardona, L.

    2000-05-01

    Flathead grey mullet (Mugil cephalus L. 1758) are commonly found in tropical and temperate estuaries. In spite of their ecological and economical importance, little is known about the effects of salinity on growth performance and habitat selection. Laboratory experiments revealed that the metabolic rate of young specimens was negatively affected by high salinity levels and that an improved growth performance was achieved in fresh water and oligohaline water. A stratified study on microhabitat use, carried out on the island of Minorca (Balearic archipelago), demonstrated that juvenile specimens, shorter than 200 mm (total length), concentrated all year round in fresh water or oligohaline sites. Mesohaline areas were usually avoided, except in summer. Immature fish, with a total length between 201 and 300 mm, show a similar pattern although in some seasons avoided freshwater sites. The habitat selection pattern of adults, i.e., fish longer than 301 mm, changed seasonally due to their offshore migration during the spawning season (from late summer to early winter). However, they usually showed a greater preference for polyhaline areas and strongly avoided freshwater sites. Euhaline areas were also avoided in autumn and summer. These results suggest that the young of this species are highly dependent on areas of low salinity and any factor which reduces the availability of such areas will, in turn, affect their fishery. Adults depend on polyhaline areas, although the avoidance of freshwater areas might be due to their shallowness. The situation might be different in some areas of the Indo-Pacific. These differences are discussed.

  5. The association between growth factors and blood factors with early childhood caries

    Directory of Open Access Journals (Sweden)

    Hoda Shamsaddin

    2017-11-01

    Full Text Available BACKGROUND AND AIM: Early childhood caries (ECC is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertaken to compare blood indices [mean corpuscular volume (MCV, hemoglobin and serum ferritin] in a population of children in Kerman, Iran, and the association between growth factors, blood parameters, and ECC. METHODS: In this cross-sectional study, 240 children were selected from Afzalipour Hospital of Kerman. The subjects consisted of 2 to 6-year children, who needed blood sampling for different diagnostic reasons. Data were collected through clinical oral examinations, anthropometric measures, blood indices measurement (MCV, hemoglobin and serum ferritin and structured questionnaire in order to assess demographic characteristics, nutritional habits and the presence or absence of systemic conditions. Data were analyzed using SPSS software. RESULTS: The mean age of subjects was 50.79 months. Of 240 children included in this study, 124 (52.1% were girls and the rest (47.9% were boys. Statistical test revealed that there were statically significant differences in weight as well as the height of children in experimental and control groups (P 0.050. CONCLUSION: No significant association was observed between ECC and blood indices (MCV, hemoglobin and serum ferritin, but the mean height and weight in the caries-free group were significantly higher.

  6. Early oral-motor management on feeding performance in premature neonates

    Directory of Open Access Journals (Sweden)

    Yan-Lin Liu

    2013-03-01

    Conclusion: Abnormal brain sonography [odds ratio (OR: 2.222, p = 0.047 and necrotizing enterocolitis (NEC (OR: 2.857, p = 0.017 did affect the first trial in the study group. Early intervention of oral-motor management in very-low-birth-weight premature infants improved feeding performance and neonatal outcome in terms of shorter hospital days. Abnormal brain image and NEC could interfere with the success rate of initial challenge of transitioning from tube to oral feeding in the study group.

  7. Catch-up growth in children born growth restricted to mothers with hypertensive disorders of pregnancy

    NARCIS (Netherlands)

    Beukers, Fenny; Cranendonk, Anneke; de Vries, Johanna I. P.; Wolf, Hans; Lafeber, Harry N.; Vriesendorp, Hester C.; Ganzevoort, Wessel; van Wassenaer-Leemhuis, Aleid G.

    2013-01-01

    In preterm hypertensive disorders of pregnancy, fetal growth restriction (FGR) occurs frequently. The timing and severity of FGR impacts childhood growth and is associated with metabolic changes later in life. To examine growth and the impact of FGR in early childhood. Prospective cohort study.

  8. Follicle and oocyte growth in early postnatal calves: cytochemical, autoradiographical and electron microscopical studies

    International Nuclear Information System (INIS)

    Mhawi, A.J.; Kaňka, J.; Motlík, J.

    1991-01-01

    The initiation of oocyte and follicle growth was studied in 1- and 3-d-old calf ovaries using cytochemical, autoradiographical and electron microscopical approaches. Attention was only paid to unilaminar ovarian follicles that were classified into 3 categories: unilaminar flattened (UF), unilaminar flatto-cuboidal (UFC) and unilaminar cuboidal (UC) ovarian follicles when the oocyte was surrounded by 1 layer of flattened, a mixture of flattened and cuboidal and entirely cuboidal follicle cells, respectively. Our findings suggested that oocytes within each of these follicle categories were in different developmental stages. Furthermore, electron microscopic observations revealed that early after birth, oocyte nuclei characteristic of diplotene configuration (aggregation of the nuclear chromatin into moderately electron-dense small patches and fibrillo-granular texture of the nucleolus) were encountered in 41% of the UF follicles. The rest of the UF as well as all of the UFC and UC follicles were found to contain dictyate oocytes in which the chromatin was highly decondensed and the nucleolus differentiated into fibrillar, fibrillo-granular and granular components. The present results also indicated that the complete transition of the surrounding follicle cells from flattened to cuboidal shape and the morphological changes of the oocyte endoplasmic reticulum and mitochondria were 2 complementary events essential for initiation of oocyte growth

  9. Le realizzazioni dell'economia sovietica. (Soviet economic performance

    Directory of Open Access Journals (Sweden)

    A. MADDISON

    2014-07-01

    Full Text Available While in the 1950s Soviet output grew faster than most other industrial countries, the early 1960s has seen a noticeable slowing down in growth. The present paper puts these economic developments into perspective to judge the efficacy of Soviet policy in its attempt to achieve maximum growth and transform an underdeveloped into a developed country. The author first assesses Soviet performance and policy at different stages of development, before assessing the level attained. The purposes for which output is used and the major factors responsible for Soviet performance are then analysed. Finally, likely future developments are considered.JEL: P27, O40

  10. Emergence Time and Skin Melanin Spot Patterns Do Not Correlate with Growth Performance, Social Competitive Ability or Stress Response in Farmed Rainbow Trout.

    Science.gov (United States)

    Gesto, Manuel; Skov, Peter V; Jokumsen, Alfred

    2017-01-01

    In wild salmonid fish, specific individual behavioral traits have been correlated with the timing of fry emergence from their gravel spawning nests; Early emerging fish display more aggressive behavior and have a higher probability of becoming socially dominant, compared to fish that emerge at a later stage. Apart from aggression and dominance, other behavioral and metabolic traits, such as boldness, metabolic rate, or growth, have also been linked to emergence time. Altogether, the traits of early- and late-emerging fish resemble those of the proactive and reactive stress-coping style, respectively. As proactive fish are considered more resilient to stress, it may be desirable to select these for aquaculture production. However, it is currently unclear to what extent the link between emergence time and stress-coping styles is maintained in the selective breeding of farmed fish. In the present study, eyed eggs from a commercial supplier were hatched, and larvae fractionated according to their emergence time. Later on, juvenile fish from different emergence fractions were subjected to a stress challenge and also tested to evaluate their competitive ability for food. Beyond some slight dissimilarities in the acute stress responses, emergence fraction displayed no correlation with growth rates, or the ability to compete for feed. Within the whole group of fish utilized in the experiments, no relationship between skin melanin spot pattern and growth performance, stress response intensity, or competitive ability was found. Altogether, the differences in physiological traits related to emergence time were not as strong as those found in earlier studies. It is hypothesized, that the origin and degree of domestication of the fish might be partly responsible for this. The predictive value of skin spots or emergence time to infer the fish stress coping style in farmed fish is also discussed.

  11. Emergence Time and Skin Melanin Spot Patterns Do Not Correlate with Growth Performance, Social Competitive Ability or Stress Response in Farmed Rainbow Trout

    Directory of Open Access Journals (Sweden)

    Manuel Gesto

    2017-06-01

    Full Text Available In wild salmonid fish, specific individual behavioral traits have been correlated with the timing of fry emergence from their gravel spawning nests; Early emerging fish display more aggressive behavior and have a higher probability of becoming socially dominant, compared to fish that emerge at a later stage. Apart from aggression and dominance, other behavioral and metabolic traits, such as boldness, metabolic rate, or growth, have also been linked to emergence time. Altogether, the traits of early- and late-emerging fish resemble those of the proactive and reactive stress-coping style, respectively. As proactive fish are considered more resilient to stress, it may be desirable to select these for aquaculture production. However, it is currently unclear to what extent the link between emergence time and stress-coping styles is maintained in the selective breeding of farmed fish. In the present study, eyed eggs from a commercial supplier were hatched, and larvae fractionated according to their emergence time. Later on, juvenile fish from different emergence fractions were subjected to a stress challenge and also tested to evaluate their competitive ability for food. Beyond some slight dissimilarities in the acute stress responses, emergence fraction displayed no correlation with growth rates, or the ability to compete for feed. Within the whole group of fish utilized in the experiments, no relationship between skin melanin spot pattern and growth performance, stress response intensity, or competitive ability was found. Altogether, the differences in physiological traits related to emergence time were not as strong as those found in earlier studies. It is hypothesized, that the origin and degree of domestication of the fish might be partly responsible for this. The predictive value of skin spots or emergence time to infer the fish stress coping style in farmed fish is also discussed.

  12. Correlation of electrolyte-derived inclusions to crystallization in the early stage of anodic oxide film growth on titanium

    Energy Technology Data Exchange (ETDEWEB)

    Jaeggi, C., E-mail: christian.jaeggi@empa.ch [Empa, Swiss Federal Laboratories for Materials Testing and Research, Advanced Materials Processing Laboratory, Feuerwerkerstrasse 39, CH-3602 Thun (Switzerland); Parlinska-Wojtan, M., E-mail: magdalena.parlinska@empa.ch [Empa, Swiss Federal Laboratories for Materials Testing and Research, Center for Electron Microscopy, Ueberlandstrasse 129, CH-8600 Duebendorf (Switzerland); Kern, P., E-mail: Philippe.Kern@neopac.ch [Empa, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Mechanics of Materials and Nanostructures, Feuerwerkerstrasse 39, CH-3602 Thun (Switzerland)

    2012-01-01

    Pure titanium has been subjected to anodization in sulfuric and phosphoric acid. For a better understanding of the oxide growth and properties of the final film, with a particular interest focused on the solution anions in the early stage of crystallization, microstructural analyses (Raman, Transmission Electron Microscopy [TEM]) of the oxide films were correlated to chemical depth profiling by glow discharge optical emission spectroscopy (GDOES). Raman spectroscopy shows that crystallization of the oxide films starts at potentials as low as 10-20 V. The onset of crystallization and the ongoing increase in crystallinity with increasing anodization potentials had already earlier been correlated to ac-impedance measurements [Jaeggi et al., Surf. Interface Anal. 38 (2006) 182]. TEM observations show a clear difference in the early phase of crystallization between oxides grown in 1 M sulfuric acid compared to 1 M phosphoric acid. Moreover, independent of electrolyte type, nano-sized pores from oxygen bubbles formation were revealed in the central part of the films. Until now, oxygen bubbles inside an anodically grown oxide have not been observed before without the presence of crystalline regions nearby. A growth model is proposed, in which the different starting locations of crystallization inside the films are correlated to the presence of the acid anions as residues in the film, as found by GDOES chemical depth-profiling.

  13. Concurrent nucleation, formation and growth of two intermetallic compounds (Cu6Sn5 and Cu3Sn) during the early stages of lead-free soldering

    International Nuclear Information System (INIS)

    Park, M.S.; Arróyave, R.

    2012-01-01

    This study investigates the concurrent nucleation, formation and growth of two intermetallic compounds (IMCs), Cu 6 Sn 5 (η) and Cu 3 Sn (ε), during the early stages of soldering in the Cu–Sn system. The nucleation, formation and growth of the IMC layers is simulated through a multiphase-field model in which the concurrent nucleation of both IMC phases is considered to be a stochastic Poisson process with nucleation rates calculated from classical nucleation theory. CALPHAD thermodynamic models are used to calculate the local contributions to the free energy of the system and the driving forces for precipitation of the IMC phases. The nucleation parameters of the η phase are estimated from experimental results and those of the ε phase are assumed to be similar. A parametric investigation of the effects of model parameters (e.g. grain boundary (GB) diffusion rates, interfacial and GB energies) on morphological evolution and IMC layer growth rate is presented and compared with previous works in which nucleation was ignored . In addition, the resulting growth rates are compared with the available literature and it is found that, for a certain range in the model parameters, the agreement is quite satisfactory. This work provides valuable insight into the dominant mechanisms for mass transport as well as morphological evolution and growth of IMC layers during early stages of Pb-free soldering.

  14. Investigating Patterns of Automation and Growth Performance among Low Level Users of Manufacturing Automation

    DEFF Research Database (Denmark)

    Matthiesen, Rikke Vestergaard; Kromann, Lene

    instrument with a new, innovative way of characterizing and measuring automation levels in the production process. The survey data is merged with elaborate Danish register data on economic performance, market, and worker characteristics. The data is available from 2000 to 2010 across a broad range......-movers; companies that develop their level of automation further and companies that remain on the 2005 level up until 2010. We compare the presence of drivers and enablers in the 5-year period leading up to 2005 and investigate patterns in growth performance on a range of economic indicators between the two groups....... However, the cross sectional nature of most studies prohibits analysis of direction; is growth and economic performance the driver of manufacturing technology investment or vice versa. Longitudinal data is required to study this. The present study analyses panel data obtained using a retrospective survey...

  15. Histological and allometric growth analysis of eye in Caspian kutum, Rutilus kutum Kamensky, 1901 (Teleostei: Cyprinidae during early developmental stages

    Directory of Open Access Journals (Sweden)

    Shaghayegh Hasanpour

    2016-10-01

    Full Text Available Fish larvae have several sensory systems that are functional at or soon after hatching and then are developed further during larval and juvenile stages. This study was conducted to investigate development of the eye in Rutilus kutum, based on histological and allometric growth analysis during early developmental stages up to 35 day post hatching with emphasis on retinal morphology. For this purpose, the histological sections were prepared and allometric growth pattern of the eye was calculated. The results showed that the most eye’s structures along with the retina of the newly hatched larvae, as the inner sensory (photosensitive tissue were completely differentiated. Allometric growth pattern of the eye diameter up to the inflexion point (7 dph was somewhat positive and then it became negative. The results revealed that the Caspian kutum is dependence on visual capability as visual feeder during their larval period which itself explains completion of eye structures and the high growth rate of eye before 3 dph i.e. beginning of mixed feeding.

  16. Growth dynamics of Australia's polar dinosaurs.

    Science.gov (United States)

    Woodward, Holly N; Rich, Thomas H; Chinsamy, Anusuya; Vickers-Rich, Patricia

    2011-01-01

    Analysis of bone microstructure in ornithopod and theropod dinosaurs from Victoria, Australia, documents ontogenetic changes, providing insight into the dinosaurs' successful habitation of Cretaceous Antarctic environments. Woven-fibered bone tissue in the smallest specimens indicates rapid growth rates during early ontogeny. Later ontogeny is marked by parallel-fibered tissue, suggesting reduced growth rates approaching skeletal maturity. Bone microstructure similarities between the ornithopods and theropods, including the presence of LAGs in each group, suggest there is no osteohistologic evidence supporting the hypothesis that polar theropods hibernated seasonally. Results instead suggest high-latitude dinosaurs had growth trajectories similar to their lower-latitude relatives and thus, rapid early ontogenetic growth and the cyclical suspensions of growth inherent in the theropod and ornithopod lineages enabled them to successfully exploit polar regions.

  17. Dietary integration with natural extract in rabbit: effects on growth performances and meat quality.

    Directory of Open Access Journals (Sweden)

    Sara Chiapparini

    2018-06-01

    Full Text Available In many countries of Europe rabbit meat is consumed for its nutritional characteristics, (Dalle Zotte, 2014; Hernández and Gondret, 2006. Since the ban of the use of antibiotic as growth promoter, natural substances have been studied as alternative with antioxidant, anti-inflammatory, antimicrobic and antiviral properties. The aim was to evaluate the effect of a dietary supplementation with natural extract mixture in growing rabbit on growth performances, carcass characteristics and Longissimus lumborum (LL muscle parameters. The trial was performed at the Research Institute for Animal Production (Nitra, Slovak Republic and lasted 42 days. At 35 days of age, 144 New Zealand White rabbits were randomly selected and divided in 3 experimental groups (4 rabbits/cage. The first fed a basal diet, the second (T1 and the third one (T2 received 0.3% and 0.6% of natural extract mixture, containing polyphenols from plants and seaweeds.  Dietary integration with natural extract improve (P<0.05 growth performances (ADG, FI and FC in T1 group. The fatty acid composition of LL muscle was positively affected (P=0.037 by natural extract supplementation with an increase of n-3 FA in T2 group than other treatments. Cholesterol content tended to be lower in T2 group (P=0.082 than T1 and C group (24.8 mg/100g T2 vs 34.6 mg/100g T1 vs 33.2 mg/100g C. Sensory analysis revealed that only the aroma was affected (P<0.05 by dietary treatments. Overall these results highlight that dietary supplementation with natural extract mixture, containing polyphenols from plants and seaweeds enhance growth performances, carcass weight, improving LL muscle nutritional parameters.

  18. Early field performance of drought-stressed scots pine (pinus sylvestris l.) seedlings

    International Nuclear Information System (INIS)

    Kulac, S.; Clcek, E.; Tasdemir, U.

    2015-01-01

    Scots pine (Pinus sylvestris) has a large natural distribution throughout the world, including semi-arid areas of Turkey, where it is being used for afforestation. Determining the drought resistance of Scots pine provenances can increase the success of afforestation efforts in semi-arid regions. In the first stage of this study, water-stress treatments were applied to ten provenances of one-year-old Scots pine seedlings in their second vegetation period (between April and November). The diameter and height of the seedlings were evaluated in the nursery in order to determine their morphology. The four drought-stress treatments consisted of once-weekly irrigation (IR1), twice-weekly irrigation (IR2-Control), biweekly irrigation (IR3) and open field conditions (IR4). Later, the water-stressed seedlings were planted in a semi-arid district in Bayburt, Turkey, and their survival and growth performances were evaluated over a five-year period. The nursery study showed that drought stress and provenance as well as the interaction of the two significantly affected the morphological characteristics of the seedlings. Under water-stress conditions, the best growth performance was found in the Dokurcun, Degirmendere and Dirgine provenance seedlings. Water-stress and provenance factors and their interaction also affected the open field performance of the seedlings, where the Degirmendere, Dirgine and Dokurcun provenances again exhibited the best performance. Consequently, these Scots pine provenances can be recommended for afforestation sites having conditions similar to those of the study site. (author)

  19. Improving growth performance in calves under hot weather conditions

    International Nuclear Information System (INIS)

    Emara, S.S.M.

    2009-01-01

    The main objectives of the present study were to evaluate the effect of some supplement such as dried live yeast DLY (Saccharomyces cerevisiae), DLY + vitamin E and / or dried whey milk (DWM) on blood constituents and thyroid activity in relation to some immune indices and growth performance of calves under hot weather conditions. The ambient temperature and relative humidity averaged 36.9±4 degree C and 43-58 % during day and 29±4 degree C and 60-68 % during night, respectively, which were equivalent to temperature humidity index of 86-89 during day and 78-80 during night . The present study included three experiments as follows. Experiment 1 : Six female bovine Baladi calves of 8-10 months old and 100 kg initial body weight (IBW) were used during two periods. In the first period, the calves were offered the basal diet for one month and considered as a control period. In the second period, the same calves were fed the same basal diet which supplemented with 15 g / calf/ day DLY for one month and considered as treated period. The obtained results indicated that supplementation of DLY reduced significantly the respiration rate (RR) and rectal temperature (RT) as well as serum lipids profile including total cholesterol, low density lipoprotein (LDL- cholesterol) very low density lipoprotein (VLDL-cholesterol) triglycerides and phospholipids.The second and third experiments were carried out for improving growth performance of heat-stressed bovine baladi calves by adding DLY and vitamine E (alpha-tocopherol) to their diet in experiment 2 and dried whey milk (DWM) in experiment 3.

  20. The Advanced Photon Source: Performance and results from early operation

    International Nuclear Information System (INIS)

    Moncton, D.E.

    1997-01-01

    The Advanced Photon Source at Argonne National Laboratory is now providing researchers with extreme-brilliance undulator radiation in the hard x-ray region of the spectrum. All technical facilities and components are operational and have met design specifications. Fourteen research teams, occupying 20 sectors on the APS experiment hall floor, are currently installing beamline instrumentation or actively taking data. An overview is presented for the first operational years of the Advanced Photon Source. Emphasis is on the performance of accelerators and insertion devices, as well as early scientific results and future plans

  1. Rhythm synchronization performance and auditory working memory in early- and late-trained musicians.

    Science.gov (United States)

    Bailey, Jennifer A; Penhune, Virginia B

    2010-07-01

    Behavioural and neuroimaging studies provide evidence for a possible "sensitive" period in childhood development during which musical training results in long-lasting changes in brain structure and auditory and motor performance. Previous work from our laboratory has shown that adult musicians who begin training before the age of 7 (early-trained; ET) perform better on a visuomotor task than those who begin after the age of 7 (late-trained; LT), even when matched on total years of musical training and experience. Two questions were raised regarding the findings from this experiment. First, would this group performance difference be observed using a more familiar, musically relevant task such as auditory rhythms? Second, would cognitive abilities mediate this difference in task performance? To address these questions, ET and LT musicians, matched on years of musical training, hours of current practice and experience, were tested on an auditory rhythm synchronization task. The task consisted of six woodblock rhythms of varying levels of metrical complexity. In addition, participants were tested on cognitive subtests measuring vocabulary, working memory and pattern recognition. The two groups of musicians differed in their performance of the rhythm task, such that the ET musicians were better at reproducing the temporal structure of the rhythms. There were no group differences on the cognitive measures. Interestingly, across both groups, individual task performance correlated with auditory working memory abilities and years of formal training. These results support the idea of a sensitive period during the early years of childhood for developing sensorimotor synchronization abilities via musical training.

  2. Understanding the mechanisms of zinc bacitracin and avilamycin on animal production: linking gut microbiota and growth performance in chickens.

    Science.gov (United States)

    Crisol-Martínez, Eduardo; Stanley, Dragana; Geier, Mark S; Hughes, Robert J; Moore, Robert J

    2017-06-01

    Unravelling the mechanisms of how antibiotics influence growth performance through changes in gut microbiota can lead to the identification of highly productive microbiota in animal production. Here we investigated the effect of zinc bacitracin and avilamycin on growth performance and caecal microbiota in chickens and analysed associations between individual bacteria and growth performance. Two trials were undertaken; each used 96 individually caged 15-day-old Cobb broilers. Trial 1 had a control group (n = 48) and a zinc bacitracin (50 ppm) treatment group (n = 48). Trial 2 had a control group (n = 48) and an avilamycin (15 ppm) treatment group (n = 48). Chicken growth performance was evaluated over a 10-day period, and caecal microbiota was characterised by sequencing of bacterial 16S rRNA gene amplicons. Avilamycin produced no effect on growth performance and exhibited little significant disturbance of the microbiota structure. However, zinc bacitracin reduced the feed conversion ratio (FCR) in treated birds, changed the composition and increased the diversity of their caecal microbiota by reducing dominant species. Avilamycin only produced minor reductions in the abundance of two microbial taxa, whereas zinc bacitracin produced relatively large shifts in a number of taxa, primarily Lactobacillus species. Also, a number of phylotypes closely related to lactobacilli species were positively or negatively correlated with FCR values, suggesting contrasting effects of Lactobacillus spp. on chicken growth performance. By harnessing such bacteria, it may be possible to develop high-productivity strategies in poultry that rely on the use of probiotics and less on in-feed antibiotics.

  3. Long-term follow-up of early cleft maxillary distraction.

    Science.gov (United States)

    Park, Young-Wook; Kwon, Kwang-Jun; Kim, Min-Keun

    2016-12-01

    Most of cleft lip and palate patients have the esthetic and functional problems of midfacial deficiencies due to innate developmental tendency and scar tissues from repeated operations. In these cases, maxillary protraction is required for the harmonious facial esthetics and functional occlusion. A 7-year old boy had been diagnosed as severe maxillary constriction due to unilateral complete cleft lip and palate. The author tried to correct the secondary deformity by early distraction osteogenesis with the aim of avoiding marked psychological impact from peers of elementary school. From 1999 to 2006, repeated treatments, which consisted of Le Fort I osteotomy and face mask distraction, and complementary maxillary protraction using miniplates were performed including orthodontics. But, final facial profile was not satisfactory, which needs compromising surgery. The result of this study suggests that if early distraction treatment is performed before facial skeletal growth is completed, an orthognathic surgery or additional distraction may be needed later. Maxillofacial plastic and reconstructive surgeons should notify this point when they plan early distraction treatment for cleft maxillary deformity.

  4. The big five personality traits and individual job performance growth trajectories in maintenance and transitional job stages.

    Science.gov (United States)

    Thoresen, Carl J; Bradley, Jill C; Bliese, Paul D; Thoresen, Joseph D

    2004-10-01

    This study extends the literature on personality and job performance through the use of random coefficient modeling to test the validity of the Big Five personality traits in predicting overall sales performance and sales performance trajectories--or systematic patterns of performance growth--in 2 samples of pharmaceutical sales representatives at maintenance and transitional job stages (K. R. Murphy, 1989). In the maintenance sample, conscientiousness and extraversion were positively associated with between-person differences in total sales, whereas only conscientiousness predicted performance growth. In the transitional sample, agreeableness and openness to experience predicted overall performance differences and performance trends. All effects remained significant with job tenure statistically controlled. Possible explanations for these findings are offered, and theoretical and practical implications of findings are discussed. (c) 2004 APA, all rights reserved

  5. The impact of initiation: Early onset marijuana smokers demonstrate altered Stroop performance and brain activation

    Directory of Open Access Journals (Sweden)

    K.A. Sagar

    2015-12-01

    Full Text Available Marijuana (MJ use is on the rise, particularly among teens and emerging adults. This poses serious public health concern, given the potential deleterious effects of MJ on the developing brain. We examined 50 chronic MJ smokers divided into early onset (regular MJ use prior to age 16; n = 24 and late onset (age 16 or later; n = 26, and 34 healthy control participants (HCs. All completed a modified Stroop Color Word Test during fMRI. Results demonstrated that MJ smokers exhibited significantly poorer performance on the Interference subtest of the Stroop, as well as altered patterns of activation in the cingulate cortex relative to HCs. Further, early onset MJ smokers exhibited significantly poorer performance relative to both HCs and late onset smokers. Additionally, earlier age of MJ onset as well as increased frequency and magnitude (grams/week of MJ use were predictive of poorer Stroop performance. fMRI results revealed that while late onset smokers demonstrated a more similar pattern of activation to the control group, a different pattern was evident in the early onset group. These findings underscore the importance of assessing age of onset and patterns of MJ use and support the need for widespread education and intervention efforts among youth.

  6. Growth dynamics of Australia's polar dinosaurs.

    Directory of Open Access Journals (Sweden)

    Holly N Woodward

    Full Text Available Analysis of bone microstructure in ornithopod and theropod dinosaurs from Victoria, Australia, documents ontogenetic changes, providing insight into the dinosaurs' successful habitation of Cretaceous Antarctic environments. Woven-fibered bone tissue in the smallest specimens indicates rapid growth rates during early ontogeny. Later ontogeny is marked by parallel-fibered tissue, suggesting reduced growth rates approaching skeletal maturity. Bone microstructure similarities between the ornithopods and theropods, including the presence of LAGs in each group, suggest there is no osteohistologic evidence supporting the hypothesis that polar theropods hibernated seasonally. Results instead suggest high-latitude dinosaurs had growth trajectories similar to their lower-latitude relatives and thus, rapid early ontogenetic growth and the cyclical suspensions of growth inherent in the theropod and ornithopod lineages enabled them to successfully exploit polar regions.

  7. Afforestation of Boreal Open Woodlands: Early Performance and Ecophysiology of Planted Black Spruce Seedlings

    Directory of Open Access Journals (Sweden)

    Daniel Lord

    2013-06-01

    Full Text Available Open lichen woodlands (LWs are degraded stands that lack the ability to regenerate naturally due to a succession of natural and/or anthropogenic disturbances. As they represent both interesting forest restoration and carbon sequestration opportunities, we tested disc scarification and planting of two sizes of containerized black spruce (Picea mariana Mill. (BSP seedlings for their afforestation. We compared treatment of unproductive LWs to reforestation of harvested, closed-crown black spruce-feathermoss (BSFM stands. After one year, seedling survival and nutritional status were equivalent among stand types but despite higher root elongation index (REI, planted seedlings in LWs had lower relative growth rate, smaller total biomass and stem diameter than those in BSFM stands. Soil fertility variables, soil temperature, nor seedling water potential, helped at explaining this early growth response. Disc scarification significantly improved seedling first-year survival, biomass and foliar nutrient concentrations of P, Ca, and Mg. Smaller planting stock showed higher REI, higher shoot water potential, and higher foliar nutrient concentration of all but one of the measured nutrients (N, P, K and Mg. Hence, preliminary results suggest that planting of smaller containerized black spruce stock, combined with disc scarification, shows potential for afforestation of unproductive LWs. The impact of the lichen mat and other potential growth limiting factors on afforestation of these sites requires further investigation.

  8. Re-translocation of boron in broccoli and lupin during early reproductive growth

    Energy Technology Data Exchange (ETDEWEB)

    Marentes, E; Shelp, B J [Univ. of Guelph, Dept. of Horticultural Science, Guelph, ON (Canada); Vanderpool, R A [USDA, Human Nutrition Research Center, Agricultural Research Service, ND (United States); [Spiers, G.A. Univ. of Guelph, Dept. of Land Resource Science, Guelph, ON (Canada)

    1997-06-01

    The objective of the present study was to determine if boron (B) re-translocation depends on plant-B status and external-B supply. The stable {sup 10}B isotope was supplied to the root system of broccoli (Brassica oleracea var. italica Plenck cv. Commander) and lupin (Lupinus albus L. cv. Ultra) plants to provide a quantitative picture of B distribution during early reproductive development. Regardless of the B regime (i.e. continuous supply with luxury, sufficient or deficient B; transfer at influorescence emergence from either a luxury- or sufficient-B supply to a deficient one) and whether {sup 10}B was acquired before or during influorescence development, a significant proportion of the B recovered in broccoli florest and lupin fruit was {sup 10}B enriched. B acquired during inflorescence development was an important source of B for reproductive structures, but the relative importance of B acquired before and after inflorescence emergence appeared to be species dependent. The occurrence of B re-translocation was not dependent upon the induction of B deficiency. The concentrations of B in phloem exsudates (0.38 to 0.03 mM) were 4- to 23-fold those in xylem sap, and more similar to the concentrations in the reproductive structures (0.86 to 0.07 mM) than those in source leaves (2.4 to 0.19 mM). The decreasing acropetal gradient of tissue-B concentrations with luxury-B supply declined dramatically or was reversed in plants grown with sufficient or deficient B. The data are consistent with B being a phloem-mobile element, and suggest that newly acquired B is particularly important during the early reproductive growth of plants. (au) 36 refs.

  9. Re-translocation of boron in broccoli and lupin during early reproductive growth

    International Nuclear Information System (INIS)

    Marentes, E.; Shelp, B.J.; Vanderpool, R.A.

    1997-01-01

    The objective of the present study was to determine if boron (B) re-translocation depends on plant-B status and external-B supply. The stable 10 B isotope was supplied to the root system of broccoli (Brassica oleracea var. italica Plenck cv. Commander) and lupin (Lupinus albus L. cv. Ultra) plants to provide a quantitative picture of B distribution during early reproductive development. Regardless of the B regime (i.e. continuous supply with luxury, sufficient or deficient B; transfer at influorescence emergence from either a luxury- or sufficient-B supply to a deficient one) and whether 10 B was acquired before or during influorescence development, a significant proportion of the B recovered in broccoli florest and lupin fruit was 10 B enriched. B acquired during inflorescence development was an important source of B for reproductive structures, but the relative importance of B acquired before and after inflorescence emergence appeared to be species dependent. The occurrence of B re-translocation was not dependent upon the induction of B deficiency. The concentrations of B in phloem exsudates (0.38 to 0.03 mM) were 4- to 23-fold those in xylem sap, and more similar to the concentrations in the reproductive structures (0.86 to 0.07 mM) than those in source leaves (2.4 to 0.19 mM). The decreasing acropetal gradient of tissue-B concentrations with luxury-B supply declined dramatically or was reversed in plants grown with sufficient or deficient B. The data are consistent with B being a phloem-mobile element, and suggest that newly acquired B is particularly important during the early reproductive growth of plants. (au) 36 refs

  10. Effects of various weaning times on growth performance, rumen fermentation and microbial population of yellow cattle calves

    Science.gov (United States)

    Mao, Huiling; Xia, Yuefeng; Tu, Yan; Wang, Chong; Diao, Qiyu

    2017-01-01

    Objective This study was conducted to investigate the effects of weaning times on the growth performance, rumen fermentation and microbial communities of yellow cattle calves. Methods Eighteen calves were assigned to a conventional management group that was normally weaned (NW, n = 3) or to early weaned (EW) group where calves were weaned when the feed intake of solid feed (starter) reached 500 g (EW500, n = 5), 750 g (EW750, n = 5), or 1,000 g (EW1,000, n = 5). Results Compared with NW, the EW treatments increased average daily gain (pcalves in EW750 had a higher (pintake than those in EW1,000 from wk 9 to the end of the trial. The concentrations of total volatile fatty acids in EW750 were greater than in NW and EW1,000 (p0.05), but changes in bacterial composition were found. Conclusion From the present study, it is inferred that EW is beneficial for rumen fermentation, and weaning when the feed intake of the starter reached 750 g showed much better results. PMID:28423879

  11. Effects of house type and early feed restriction on performance and fat deposition in unsexed broilers

    Directory of Open Access Journals (Sweden)

    U Santoso

    2002-06-01

    Full Text Available The present experiment was conducted to evaluate the effects of house type and early feed restriction on performance and fat deposition of unsexed broilers. Four hundreds seven-day old unsexed broilers (Arbor Acres CP 707 were distributed into eight treatment groups. Each treatment group was represented by five replicates of ten broilers each. Two types of house (cage vs litter and four levels of feeding (ad lib., 75% ad lib., 50% ad lib. and 25% ad lib. were tested as treatment factors. Broilers were feed-restricted for 6 days from 7 to 13 days of age and thereafter they were fed ad lib. Feed intake of restricted broilers during restriction period was calculated from feed consumed by ad lib. group in the previous day. Results showed that unsexed broilers raised in litter had higher body weight (P<0.05, lower abdominal fat and higher triglyceride concentration at 42 days of age (P<0.05, and lower liver fat and higher carcass percentage at 56 days of age (P<0.05. Early feed restriction reduced body weight of 42-day old unsexed broilers except for broilers fed 75% ad lib. At 56 days of age, restricted broilers had similar body weight to those fed ad lib. At 56 days of age, broilers fed 25% ad lib. had lower FCR (P<0.05, lower abdominal fat (P<0.05 and lower triglyceride concentration (P<0,05. In conclusion, unsexed broilers fed 25% ad lib. showed compensatory growth with better FCR and lower fat accumulation at 56 days of age. Broilers raised in litter had higher body weight and lower abdominal and liver fat deposition.

  12. Long-term monitoring of Sacramento Shade program trees: tree survival, growth and energy-saving performance

    Science.gov (United States)

    Yekang Ko; Jun-Hak Lee; E. Gregory McPherson; Lara A. Roman

    2015-01-01

    Long-term survival and growth of urban forests are critical to achieve the targeted benefits of urban tree planting programs, such as building energy savings from tree shade. However, little is known about how trees perform in the long-term, especially in residential areas. Given this gap in the literature, we monitored 22-years of post-planting survival, growth, and...

  13. Adult height after spontaneous pubertal growth or GnRH analog treatment in girls with early puberty: a meta-analysis.

    Science.gov (United States)

    Bertelloni, Silvano; Massart, Francesco; Miccoli, Mario; Baroncelli, Giampiero I

    2017-06-01

    Early puberty (EP) has been defined as the onset of puberty in the low-normal range; it may be a cause for concern regarding a possible impairment of adult height (AH). This paper meta-analysed data on AH after spontaneous growth or after gonadotropin-releasing hormone (GnRH) analog treatment in girls with EP. A computerized literature search was conducted from 1980 to June 30, 2016. Only published studies in English were considered. Eight papers were selected (483 cases). In untreated girls (n = 300), predicted adult height (PAH) at start of follow-up (-0.559 SDS (95%CI -1.110 to 0.001); P = 0.050) was close to mid-parental height (MPH) (-0.557 SDS (95%CI -0.736 to -0.419); P adult height. What is New: • Untreated and GnRH analog treated girls with early puberty reached similar adult height. • Adult height was consistent with mid-parental height in both untreated and GnRH analog treated girls with early puberty.

  14. Facilitative and Inhibitory Effect of Litter on Seedling Emergence and Early Growth of Six Herbaceous Species in an Early Successional Old Field Ecosystem

    Directory of Open Access Journals (Sweden)

    Qiang Li

    2014-01-01

    Full Text Available In the current study, a field experiment was conducted to examine effects of litter on seedling emergence and early growth of four dominant weed species from the early successional stages of old field ecosystem and two perennial grassland species in late successional stages. Our results showed that increased litter cover decreased soil temperature and temperature variability over time and improved soil moisture status. Surface soil electrical conductivity increased as litter increased. The increased litter delayed seedling emergence time and rate. The emergence percentage of seedlings and establishment success rate firstly increased then decreased as litter cover increased. When litter biomass was below 600 g m−2, litter increased seedlings emergence and establishment success in all species. With litter increasing, the basal diameter of seedling decreased, but seedling height increased. Increasing amounts of litter tended to increase seedling dry weight and stem leaf ratio. Different species responded differently to the increase of litter. Puccinellia tenuiflora and Chloris virgata will acquire more emergence benefits under high litter amount. It is predicted that Chloris virgata will dominate further in this natural succession old field ecosystem with litter accumulation. Artificial P. tenuiflora seeds addition may be required to accelerate old field succession toward matured grassland.

  15. Facilitative and inhibitory effect of litter on seedling emergence and early growth of six herbaceous species in an early successional old field ecosystem.

    Science.gov (United States)

    Li, Qiang; Yu, Pujia; Chen, Xiaoying; Li, Guangdi; Zhou, Daowei; Zheng, Wei

    2014-01-01

    In the current study, a field experiment was conducted to examine effects of litter on seedling emergence and early growth of four dominant weed species from the early successional stages of old field ecosystem and two perennial grassland species in late successional stages. Our results showed that increased litter cover decreased soil temperature and temperature variability over time and improved soil moisture status. Surface soil electrical conductivity increased as litter increased. The increased litter delayed seedling emergence time and rate. The emergence percentage of seedlings and establishment success rate firstly increased then decreased as litter cover increased. When litter biomass was below 600 g m(-2), litter increased seedlings emergence and establishment success in all species. With litter increasing, the basal diameter of seedling decreased, but seedling height increased. Increasing amounts of litter tended to increase seedling dry weight and stem leaf ratio. Different species responded differently to the increase of litter. Puccinellia tenuiflora and Chloris virgata will acquire more emergence benefits under high litter amount. It is predicted that Chloris virgata will dominate further in this natural succession old field ecosystem with litter accumulation. Artificial P. tenuiflora seeds addition may be required to accelerate old field succession toward matured grassland.

  16. 198Au grain implantation for early tongue cancer in patients of advanced age or poor performance status

    International Nuclear Information System (INIS)

    Ryu, Yoshiharu; Shibuya, Hitoshi; Hayashi, Keiji

    2013-01-01

    Brachytherapy using 198 Au grains is minimally invasive and the only curative treatment for early tongue cancer in patients of advanced age or poor performance status available in our institution. From March 1993 to February 2008, 198 Au grains were used to treat a group of 96 Stage I–II tongue cancer patients who could not undergo surgery or brachytherapy using 192 Ir pins because of an advanced age (≥75 years) or poor performance status (≥2). The patients were followed for 3.9 ± 3.3 years, and the cause-specific survival and local control rates were determined. Survival analyses were performed using the Kaplan-Meier method, and univariate and multivariate analyses were performed using the Cox proportional hazard model. The results were compared with those for a group of 193 early tongue-cancer patients who underwent treatment using iridium pins. The 5-year cause-specific survival and local control rates of the 198 Au grains group were 71% and 68%, respectively, both of which were 16% lower than the corresponding rates for the 192 Ir pins group. Our study demonstrated that as the last curative treatment available, 198 Au grain implantation could be used to achieve moderate treatment results for early tongue cancer in patients of advanced age or poor performance status

  17. A preliminary study of the effects of plastic film-mulched raised beds on soil temperature and crop performance of early-sown short-season spring maize (Zea mays L. in the North China Plain

    Directory of Open Access Journals (Sweden)

    Jing Dang

    2016-08-01

    Full Text Available To identify a strategy for earlier sowing and harvesting of spring maize (Zea mays L. in an alternative maize–maize double cropping system, a 2-year field experiment was performed at Quzhou experimental station of China Agricultural University in 2014 and 2015. A short-season cultivar, Demeiya number 1 (KX7349, was used in the experiment. Soil temperature to 5 cm depth in the early crop growth stage, crop growth, crop yield, and water use of different treatments (plastic film-mulched raised bed (RF and flat field without plastic film mulching (CK in 2014; RF, plastic film-mulched flat field (FF, and CK in 2015 were measured or calculated and compared. Soil temperature in the film-mulched treatments was consistently higher than that in CK (1.6–3.5 °C in average during the early growth stage. Crops in plastic film-mulched treatments used 214 fewer growing-degree days (GDDs in 2014 and 262 fewer GDDs in 2015. In 2014, the RF treatment yielded 32.7% higher biomass than CK, although its 9.4% higher grain yield was not statistically significant. Also, RF used 17.9% less water and showed 33.1% higher water use efficiency (WUE than CK. In 2015, RF and FF showed 56.2% and 49.5% higher yield, 15.0% and 4.5% lower water use (ET, and 63.4% and 75.7% higher WUE, respectively, than CK. RF markedly increased soil temperature in the early crop season, accelerated crop growth, reduced ET, and greatly increased crop yield and WUE. Compared with FF, RF had no obvious effect on crop growth rate, although soil temperature during the period between sowing and stem elongation was slightly increased. However, RF resulted in lower ET and higher WUE than FF. Effects of RF on soil water dynamics as well as its cost-effectiveness remain topics for further study.

  18. Early changes of serum insulin-like growth factor-II (IGF-II) levels in patients with acute brain injury

    International Nuclear Information System (INIS)

    Liu Cegang; Zhang Xinlu; Tao Jin; Xu Anding; Xu Shanshui; Huang Zhenpeng

    2003-01-01

    Objective: To investigate the early changes and clinical significance of serum Insulin-like growth factor-II (IGF-II) levels in patients with acute brain injury. Methods: Radioimmunoassay was used for measurement of the serum IGF-II concentration in 30 controls and 29 acute brain injury patients before and after treatment (within 1 day, at 3 and 7 days). Results: The serum IGF-II levels in brain injury patients at 1 day, 3 day 7 days after injury were 0.131 ± 0.047 ng/ml, 0.117 ± 0.046 ng/ml and 0.123 ±0.050 ng/ml respectively and were significantly lower than those in controls 0.44 ± 0.014 ng/ml, p<0.01. Differences among the values of the three days were not significant. Conclusion: IGF-II might play important role in the pathophysiological process of early acute brain injury

  19. Emotional education in Early Childhood Education teachers: a key aspect in teaching performance

    Directory of Open Access Journals (Sweden)

    María del Camino Escolar Llamazares

    2017-02-01

    Full Text Available Based on the importance of emotional education in Early Childhood students it is equally important that these skills are also present in the training of teachers. The objective is to analyze the training offered by the CFIEs of Burgos and Miranda de Ebro to Early Childhood teachers about emotional education. This is a descriptive cross-sectional study. In relation to the results, the analysis focuses on the study of frequencies using the SPPS statistical program v. 22. Results: We obtain that 69.9% of the courses taken include in the title a term related to emotional education or emotional intelligence, that such courses has tripled in recent years, public schools being mostly what carried them. The main beneficiaries are the teachers of the Early Childhood and primary education. In conclusion, the emotional education in the performance of teachers of Early Childhood it is a key aspect so that they can implement active methodologies that facilitate the overall development of students, so despite the continuing education program related to these aspects is increasing in recent years, it would require that responsible for CFIEs establish an action plan to develop in all areas of the province of Burgos.

  20. Molecular-beam epitaxy growth of high-performance midinfrared diode lasers

    International Nuclear Information System (INIS)

    Turner, G.W.; Choi, H.K.; Calawa, D.R.

    1994-01-01

    Recent advances in the performance of GaInAsSb/AlGaAsSb quantum-well diode lasers have been directly related to improvements in the quality of the molecular-beam epitaxy (MBE)-grown epitaxial layers. These improvements have been based on careful measurement and control of lattice matching and intentional strain, changes in shutter sequencing at interfaces, and a generally better understanding of the growth of Sb-based epitaxial materials. By using this improved MBE-grown material, significantly enhanced performance has been obtained for midinfrared lasers. These lasers, which are capable of ∼2-μm emission at room temperature, presently exhibit threshold current densities of 143 A/cm 2 , continuous wave powers of 1.3 W, and diffraction-limited powers of 120 mW. Such high-performance midinfrared diode lasers are of interest for a wide variety of applications, including eye-safe laser radar, remote sensing of atmospheric contaminants and wind turbulence, laser surgery, and pumping of solid-state laser media. 12 refs., 3 figs

  1. Effect of feeding silkworm on growth performance and feed efficiency of snakehead (Channa striata)

    Science.gov (United States)

    Firmani, U.; Lono

    2018-04-01

    The snakehead, Chana striata is a carnivorous freshwater fish and widely distributed in Asia. High demand of this fish has been triggering many aquaculturist to culture C. stiata. Feed was the important factor for fish growth. Silkworm has high protein content, low fat and can be used as natural feed for finfish. This study investigate the silkworm feed in C. striata. The treatment of this research were A (100 % pellet); B (100 % silkworm); C (combination of 75 % pellet and 25 % silkworm); D (combination of 50 % pellet and 50 % silkworm); and E (combination of 25 % pellet and 75 % silkworm). The variables measured in this study were relatif growth, specific growth rate, feed efficiency, feed conversion ratio, and survival rate. The result show that silkworm gave the high growth performance, feed efficiency and survival rate of the snakehead (Channa striata) compared with the control.

  2. Cognitive performance patterns in healthy individuals with substantia nigra hyperechogenicity and early Parkinson’s disease

    Directory of Open Access Journals (Sweden)

    Rezzak Yilmaz

    2016-11-01

    Full Text Available Introduction: Hyperechogenicity of the substantia nigra (SN+ is a risk marker for Parkinson’s disease (PD which can be detected before the diagnosis. In healthy individuals, SN+ has been associated with slight deficits in specific cognitive functions, suggesting cognitive impairment as a possible pre-diagnostic marker for PD. However, the pattern of cognitive deficits associated with SN+ has not yet been compared with those present in PD.Methods: Data of 262 healthy individuals with normal echogenicity (SN- and 48 healthy individuals with SN+ were compared with 82 early stage PD patients using the Consortium to Establish a Registry for Alzheimer’s disease test battery. First, the test clusters (factors were identified using a principal component analysis (PCA. Mean group performance of cognitive tests belonging to distinct factors, according to the PCA, and single subtest performances were compared using analyses of variance. Second, the number of individuals with abnormal cognitive performances (z-score <-1.0 were compared between groups. Results: Verbal memory, semantic and executive function, and praxis were identified as components of cognitive performances. The SN+ group performed significantly worse than the SN- group in tests assessing semantic and executive function, with a non-significant decrease in verbal memory. On the subtest level, individuals of the SN+ group scored significantly lower than the SN- group on the Boston Naming Test (BNT (p=0.008. In all subtests, the percentages of PD patients with values below the cut-off for abnormal performance were higher than in the SN- group. Moreover, more individuals from the SN+ group scored below the cut-off in the BNT (SN-=8.4%, SN+=20.8%, p=0.01 and TMT-B (SN-=6.9%, SN+=16.7%, p=0.02, compared to the SN- group. Conclusion: This study confirms poorer performance of healthy individuals with SN+ compared to SN- in specific cognitive domains. However, against the SN- group, the cognitive

  3. EFFECT OF HUMIC SUBSTANCES AND PROBIOTICS ON GROWTH PERFORMANCE AND MEAT QUALITY OF RABBITS

    Directory of Open Access Journals (Sweden)

    Vladimír Parkányi

    2012-04-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4  The aim of this work was determined effect of supplemental humic substances and probiotics on growth performance and meat quality of rabbits.  The growth performances were observed on two hundred and twelve growing rabbits assigned randomly by weight to two treatments. The treatments included: 1 Control group: in this group were rabbits fed with basal diet during all experiment (35th – 77th day, 2 experimental group: the animals were fed with basal diet+3kg/t humic substances – Humac Nature during whole experiment.  In this group was during fattening period (35th – 49th and 63rd – 70th days of age added to feed the probiotic preparation – Propoul (Lactobacillus fermentum CCM 7158 1x108 CFU 2 g per ten pieces. Body weight and feed intake were measured weekly in order to determine the average daily gain, average daily feed intake and gain/feed. The characteristics of meat quality were determined on twelve rabbit males at the age of 77 days, when the rabbits achieved average slaughter weight 2500g. Results of the whole experimental period showed that addition humic substances and probiotic preparation to the diet had positive effect (not significantly on intensity of growth live weight in the last phase of fattening period. The results of this study suggest that humic substances with probiotics might be utilized as a feed additive in the rabbit diet. It could not significantly improve growth performance and meat quality of rabbits.doi:10.5219/192 

  4. Post-fire wood management alters water stress, growth, and performance of pine regeneration in a Mediterranean ecosystem

    Science.gov (United States)

    Maranon-Jimenez, Sara; Castro, Jorge; Querejeta, José Ignacio; Fernandez-Ondono, Emilia; Allen, Craig D.

    2013-01-01

    Extensive research has focused on comparing the impacts of post-fire salvage logging versus those of less aggressive management practices on forest regeneration. However, few studies have addressed the effects of different burnt-wood management options on seedling/sapling performance, or the ecophysiological mechanisms underlying differences among treatments. In this study, we experimentally assess the effects of post-fire management of the burnt wood on the growth and performance of naturally regenerating pine seedlings (Pinus pinaster). Three post-fire management treatments varying in degree of intervention were implemented seven months after a high-severity wildfire burned Mediterranean pine forests in the Sierra Nevada, southeast Spain: (a) “No Intervention” (NI, all burnt trees left standing); (b) “Partial Cut plus Lopping” (PCL, felling most of the burnt trees, cutting off branches, and leaving all the biomass on site without mastication); and (c) “Salvage Logging” (SL, felling the burnt trees, piling up the logs and masticating the fine woody debris). Three years after the fire, the growth, foliar nutrient concentrations, and leaf carbon, nitrogen and oxygen isotopic composition (δ13C, δ18O and δ15N) of naturally regenerating seedlings were measured in all the treatments. Pine seedlings showed greatest vigor and size in the PCL treatment, whereas growth was poorest in SL. The nutrient concentrations were similar among treatments, although greater growth in the two treatments with residual wood present indicated higher plant uptake. Seedlings in the SL treatment showed high leaf δ13C and δ18O values indicating severe water stress, in contrast to significantly alleviated water stress indications in the PCL treatment. Seedling growth and physiological performance in NI was intermediate between that of PCL and SL. After six growing seasons, P. pinaster saplings in PCL showed greater growth and cone production than SL saplings. In summary

  5. The Effect of Wallow on Growth Performance of Pre-Pubertal Pigs in ...

    African Journals Online (AJOL)

    A study was carried out to determine the influence of wallow on the growth performance of growing pigs. Sixteen (16) pre-pubertal pigs (8 males and 8 females) of large white breed, aged three months were randomly assigned to two treatments. There were eight animals per group designated as treatment A = with wallow ...

  6. Early age stress-crack opening relationships for high performance concrete

    DEFF Research Database (Denmark)

    Østergaard, Lennart; Lange, David A.; Stang, Henrik

    2004-01-01

    Stress–crack opening relationships for concrete in early age have been determined for two high performance concrete mixes with water to cementitious materials ratios of 0.307 and 0.48. The wedge splitting test setup was used experimentally and the cracked nonlinear hinge model based...... on the fictitious crack model was applied for the interpretation of the results. A newly developed inverse analysis algorithm was utilized for the extraction of the stress–crack opening relationships. Experiments were conducted at 8, 10, 13, 17, 22, 28, 48, 168 h (7 days) and 672 h (28 days). At the same ages...

  7. Invited review: Carryover effects of early lactation feeding on total lactation performance in dairy cows

    DEFF Research Database (Denmark)

    Jørgensen, Carina; Spörndly, R; Bertilsson, J

    2016-01-01

    In comparison with the intensive research on the direct effects of energy supply on dairy cow lactation performance, little attention has been paid to the effect of early lactation feeding on subsequent production. The present paper reviews 9 studies carried out with the aim of quantifying...... the immediate and subsequent responses in milk production and body weight to early lactation feeding. Most results showed that a more generous feeding in early lactation caused a positive carryover effect on subsequent production, whereas an inadequate level of feed in early lactation has been shown to reduce...... to be determined by several factors including duration of the treatment and post-treatment feeding level. The most important factor though appears to be the magnitude of over- or underfeeding (i.e., a strong relationship between the treatment period feeding level and the subsequent response in production)....

  8. Effects of copra (Cocos nucifera) meal on the growth performance of Cyprinus carpio

    Science.gov (United States)

    Yusup, Cep Hikmat Maulana; Nugroho, Rudy A.

    2017-02-01

    This research aimed to evaluate the optimum concentration of copra meal as a fish meal replacement on the growth performance of Cyprinus carpio. Various concentrations of copra (Cocos nucifera) meal, viz 3, 6, 9, and 12 % were used to determine the final weight, body weight gain (BWG), average weekly gain (AWG), daily weight gain (DWG), specific growth rate (SGR), protein efficiency ratio (PER), feed conversion ratio (FCR) of the C. carpio (Initial body weight 25-25.2 g/fish) and compare with control group (Basal diet) without copra meal replacement and commercial diet (CD). Six groups of C. carpio with three replicates were used and fed with different concentration of copra meal at satiation level five times per day for 12 weeks. At the end of feeding trial, the C. carpio fed 9% copra meal in the diet had higher final weight, BWG, AWG, DWG, SGR than any other groups, except commercial diet (CD). Meanwhile, the highest PER was found on the fish fed CD, followed by fish fed 3 % of copra meal in the diet. However, FCR was not affected by any types of diets. These finding suggested that the 9% replacement of wheat in the diet with copra meal is beneficial to improve growth performance.

  9. Growth in pediatric renal transplant recipients.

    Science.gov (United States)

    Vasudevan, A; Phadke, K

    2007-04-01

    One of the fundamental challenges in managing pediatric renal transplant recipient is to ensure normal growth and development. The goal of renal transplant is not just to prolong life but to optimize quality of life. Short stature during childhood may be associated with academic underachievement and development of comorbidities such as attention deficit hyperactivity disorder, learning disability, and mood disorders. The most important factors affecting growth are use of corticosteroids, allograft function, and age and height deficit at the time of transplant. Aggressive conservative management of chronic renal failure and early use of growth hormone therapy will help in optimizing height at time of transplant. Early transplant, steroid minimization or withdrawal, and growth hormone therapy will help in achieving normal adult height in a majority of renal post transplant population. Steroid avoidance to achieve good growth still needs to be validated.

  10. Growth performance, haematological and biochemical study of ...

    African Journals Online (AJOL)

    A significant difference (P<0.05) was established in the growth parameters determined in the C. gariepinus fingerlings fed with the four frog formulations, namely, final weight, total weight, and mean feed gain, mean weight gain and feed conversion ratio The 40% R. galamensis ration elicited higher growth values than all ...

  11. Early Programming by Protein Intake: The Effect of Protein on Adiposity Development and the Growth and Functionality of Vital Organs

    Directory of Open Access Journals (Sweden)

    Veronica Luque

    2015-01-01

    Full Text Available This article reviews the role of protein intake on metabolic programming early in life. The observations that breastfeeding in infancy reduces the risk of being overweight and obese later in life and the differences in the protein content between formula milk and human milk have generated the early protein hypothesis. The present review focuses on a mechanistic approach to programmed adiposity and the growth and development of other organs by protein intake in infancy, which may be mediated by branched-chain amino acids, insulin, and insulin-like growth factor 1 via the mammalian target of rapamycin. Observational studies and clinical trials have shown that lowering the protein content in infant and follow-on formulas may reduce the risk of becoming obese later in life. The recent body of evidence is currently being translated into new policies. Therefore, the evolution of European regulatory laws and recommendations by expert panels on the protein content of infant and follow-on formulas are also reviewed. Research gaps, such as the critical window for programming adiposity by protein intake, testing formulas with modified amino acids, and the long-term consequences of differences in protein intake on organ functionality among well-nourished infants, have been identified.

  12. Effects of different space allowances on growth performance, blood profile and pork quality in a grow-to-finish production system

    Directory of Open Access Journals (Sweden)

    J. C. Jang

    2017-12-01

    Full Text Available Objective This experiment was conducted to evaluate the optimal space allowance on growth performance, blood profile and pork quality of growing-finishing pigs. Methods A total of ninety crossbred pigs [(Yorkshire×Landrace×Duroc, 30.25±1.13 kg] were allocated into three treatments (0.96: four pigs/pen, 0.96 m2/pig; 0.80: five pigs/pen, 0.80 m2/pig; 0.69: six pigs/pen, 0.69 m2/pig in a randomized complete block design. Pigs were housed in balanced sex and had free access to feed in all phases for 14 weeks (growing phase I, growing phase II, finishing phase I, and finishing phase II. Results There was no statistical difference in growing phase, but a linear decrease was observed on average daily gain (ADG, p<0.01, average daily feed intake (ADFI, p<0.01, and body weight (BW, p<0.01 with decreasing space allowance in late finishing phase. On the other hand, a quadratic effect was observed on gain to feed ratio in early finishing phase (p<0.03. Consequently, overall ADG, ADFI, and final BW linearly declined in response to decreased space allowance (p<0.01. The pH of pork had no significant difference in 1 hour after slaughter, whereas there was a linear decrease in 24 h after slaughter with decreasing space allowance. Floor area allowance did not affect pork colors, but shear force linearly increased as floor space decreased (p<0.01. There was a linear increase in serum cortisol concentration on 14 week (p<0.05 with decreased space allocation. Serum IgG was linearly ameliorated as space allowance increased on 10 week (p<0.05 and 14 week (p<0.01. Conclusion Data from current study indicated that stress derived from reduced space allowance deteriorates the immune system as well as growth performance of pigs, resulting in poor pork quality. Recommended adequate space allowance in a grow-to-finish production system is more than 0.80 m2/pig for maximizing growth performance and production efficiency.

  13. Effect of system of lamb rearing and season on early post-partum fertility of ewes and growth performance of lambs in Katahdin sheep.

    Science.gov (United States)

    Rastle-Simpson, S; D'Souza, K; Redhead, A; Singh-Knights, D; Baptiste, Q; Knights, M

    2017-10-01

    The effect of season (S), lamb rearing system (RT) and grain supplementation (GS) on post-partum fertility in Katahdin ewes and growth in Katahdin lambs was evaluated. Katahdin ewes were bred to lamb in fall (n = 36) or spring (n = 56) and at approximately 2.5 months post-partum were randomly assigned to be permanently separated or to continue to suckle their lambs for an additional 3 months. All ewes were joined with rams following treatment to synchronize oestrus. Weaned (W, n = 84) and continuously suckled lambs (CSK, n = 88) were fed forage only (n = 84; hay and pasture for fall- and spring-born lambs respectively) or were supplemented (n = 88; 18% crude protein ration ad libitum) and all weighed biweekly. Ewes rebred in the fall had a shorter ram introduction to lambing interval (p ewes lambing was not affected by season. The first service lambing rate was lower in ewes continuously suckling lambs in the spring, but not in the fall breeding season (S × RT, p = 0.03). Lambs that continuously suckled their dams and were supplemented grew quicker and gained more (p ewes are capable of early rebreeding post-partum while suckling their lambs, which makes them suited for use in accelerated lambing programmes. Journal of Animal Physiology and Animal Nutrition © 2016 Blackwell Verlag GmbH.

  14. Growth & development of Indian children adopted in Sweden.

    Science.gov (United States)

    Proos, Lemm A

    2009-11-01

    More than 6800 children from India have been adopted in Sweden over the last four decades. At arrival many were undernourished and suffered from infectious diseases. Catch-up growth was common. Unexpectedly, cases of early pubertal development were subsequently reported. In order to investigate the growth and development of adopted children more in detail we studied 114 children adopted from India prospectively during two years. The majority were stunted at arrival and caught up in height and weight after two years. Psychomotor retardation and common infections diminished fairly soon. Those that were stunted did not attain the higher catch-up levels of those not stunted at arrival. Low birthweight also limited the degree of catch-up growth. 107 girls were analysed retrospectively in another study. The median menarcheal age was 11.6 yr (range 7.3-14.6 yr) which is significantly earlier than the mean in Swedish and privileged Indian girls (13.0 and 12.4-12.9 yr, respectively). The pubertal linear growth component was normal in duration and magnitude but likewise started 1.5 yr earlier. The final height/age was 154 cm (-1.4 SDS) and the weight/age 46.9 kg (-1.1 SDS) 8 per cent were 145 cm or shorter. Stunting limited catch-up growth and final height. Those that were most stunted at arrival, and had the fastest catch-up growth, had the earliest menarche. Good maternal and child nutrition is necessary for full expression of a child's growth potential. What is lost in growth early in life can only partially be recovered by catch-up growth. Such growth is associated with risk for early pubertal development which abbreviates the childhood growth period and limits final height. The mechanism underlying the early pubertal development, and the optimal management of nutrition rehabilitation after chronic malnutrition, need to be clarified by further studies.

  15. Impact of iron supplementation and deworming on growth performance in preschool Beninese children

    NARCIS (Netherlands)

    Dossa, R.A.M.; Ategbo, E.A.D.; Koning, de F.L.H.A.; Raaij, van J.M.A.; Hautvast, J.G.A.J.

    2001-01-01

    To assess the effects of iron and deworming on linear growth performance of preschoolers. Design: Three-month randomized, double-blind and placebo-controlled trial. The children were allocated to four treatments: iron (60 mg elemental iron/day) albendazole (200 mg/day for 3 consecutive days,

  16. Predicting plant performance under simultaneously changing environmental conditions – the interplay between temperature, light and internode growth

    Directory of Open Access Journals (Sweden)

    Katrin eKahlen

    2015-12-01

    Full Text Available Plant performance is significantly influenced by prevailing light and temperature conditions during plant growth and development. For plants exposed to natural fluctuations in abiotic environmental conditions it is however laborious and cumbersome to experimentally assign any contribution of individual environmental factors to plant responses. This study aimed at analyzing the interplay between light, temperature and internode growth based on model approaches. We extended the light-sensitive virtual plant model L-Cucumber by implementing a common Arrhenius function for appearance rates, growth rates and growth durations. For two greenhouse experiments, the temperature-sensitive model approach resulted in a precise prediction of cucumber mean internode lengths and number of internodes, as well as in accurately predicted patterns of individual internode lengths along the main stem. In addition, a system’s analysis revealed that environmental data averaged over the experimental period were not necessarily related to internode performance. Finally, the need for a species-specific parameterization of the temperature response function and related aspects in modelling temperature effects on plant development and growth is discussed.

  17. Delayed phenotypic expression of growth hormone transgenesis during early ontogeny in Atlantic salmon (Salmo salar?

    Directory of Open Access Journals (Sweden)

    Darek T R Moreau

    Full Text Available Should growth hormone (GH transgenic Atlantic salmon escape, there may be the potential for ecological and genetic impacts on wild populations. This study compared the developmental rate and respiratory metabolism of GH transgenic and non-transgenic full sibling Atlantic salmon during early ontogeny; a life history period of intense selection that may provide critical insight into the fitness consequences of escaped transgenics. Transgenesis did not affect the routine oxygen consumption of eyed embryos, newly hatched larvae or first-feeding juveniles. Moreover, the timing of early life history events was similar, with transgenic fish hatching less than one day earlier, on average, than their non-transgenic siblings. As the start of exogenous feeding neared, however, transgenic fish were somewhat developmentally behind, having more unused yolk and being slightly smaller than their non-transgenic siblings. Although such differences were found between transgenic and non-transgenic siblings, family differences were more important in explaining phenotypic variation. These findings suggest that biologically significant differences in fitness-related traits between GH transgenic and non-transgenic Atlantic salmon were less than family differences during the earliest life stages. The implications of these results are discussed in light of the ecological risk assessment of genetically modified animals.

  18. The Effectiveness of Peer Review of Teaching When Performed between Early-Career Academics

    Science.gov (United States)

    Woodman, Richard J.; Parappilly, Maria B.

    2015-01-01

    The success of peer review of teaching (PRT) in shaping teaching practice during an academic's formative years may depend on the peers' teaching experience and the frequency of evaluation. Two Australian early-career University lecturers with no previous experience of peer review performed a single PRT on one another following a one week academic…

  19. Disturbances in Maternal Steroidogenesis and Appearance of Intrauterine Growth Retardation at High-Altitude Environments Are Established from Early Pregnancy. Effects of Treatment with Antioxidant Vitamins.

    Directory of Open Access Journals (Sweden)

    Victor H Parraguez

    Full Text Available Pregnancies at high-altitudes are influenced by hypoxia and oxidative stress and frequently affected by IUGR. However, a common thought is that early pregnant women visiting altitude have no major complications for gestation development, since IUGR is developed during the second half of pregnancy. Thus, using a well-characterized sheep-model, we aimed to determine whether long- and/or short-term exposure to high-altitude may affect maternal steroidogenesis and therefore embryo-fetal growth from conception. The second aim was to differentiate the relative role of hypoxia and oxidative stress by assessing the effects of supplementation with antioxidant agents during this early-pregnancy stage, which were previously found to be useful to prevent IUGR. The results indicate that both long- and short-term exposure to high-altitude causes disturbances in maternal ovarian steroidogenesis and negatively affects embryo-fetal growth already during the very early stages of gestation, with the consequences being even worsened in newcomers to high-altitude. The supply of antioxidant during this period only showed discrete effects for preventing IUGR. In conclusion, the present study gives a warning for clinicians about the risks for early-pregnant women when visiting high-altitude regions and suggests the need for further studies on the effects of the length of exposure and on the interaction of the exposure with the pregnancy stage.

  20. Early growth patterns and cardiometabolic function at the age of 5 in a multiethnic birth cohort: the ABCD study

    Directory of Open Access Journals (Sweden)

    Vrijkotte Tanja GM

    2009-03-01

    Full Text Available Abstract Background The relation between fetal growth retardation and cardiovascular and metabolic diseases in later life has been demonstrated in many studies. However, debate exists around the potential independent role of postnatal growth acceleration. Furthermore, it is unknown whether a potential effect of growth acceleration on cardiovascular and metabolic function is confined to certain timeframes. The present study assesses the (predictive role of prenatal and postnatal growth on 5 components of cardiovascular and metabolic function in children aged 5. The potential association of timing of postnatal growth acceleration with these outcomes will be explored. Methods and design Prospective multiethnic community-based cohort study of 8266 pregnancies (Amsterdam Born Children and their Development, ABCD study. Up till now, anthropometry of 5104 children from the original cohort was followed during the first 5 years of life, with additional information about birth weight, pregnancy duration, and various potential confounding variables. At age 5, various components of cardiovascular and metabolic function are being measured. Outcome variables are body size, body composition and fat distribution, insulin sensitivity, lipid profile, blood pressure and autonomic regulation of cardiovascular function. Discussion This study will be one of the first population-based prospective cohort studies to address the association between measures of both prenatal and postnatal growth and various components of cardiovascular and metabolic function. Specific attention is paid to the timing of acceleration in growth and its potential association with the outcome variables. Importantly, the longitudinal design of this study gives us the opportunity to gain more insight into growth trajectories associated with adverse outcomes in later life. If identified as an independent risk factor, this provides further basis for the hypothesis that accelerated growth during

  1. Early numeracy performance of South African school beginners

    Directory of Open Access Journals (Sweden)

    Pirjo Aunio

    2016-12-01

    Full Text Available Early numeracy skills are highly relevant for children’s mathematics learning at school, especially in the initial years when much mathematics learning relies on early numeracy competence. The aim of this study was to investigate the level of early numeracy skills in a sample of South African children in the first months of formal schooling. In this cross- sectional study, there were 443 first graders (206 girls and 237 boys from Gauteng Province schools. The mean age of the children was 81.61 months (6 years 10 months (SD 5.40 months. Their early numeracy skills were measured with the ThinkMath Scale. The main finding of this study was that there were statistically significant differences in early numeracy skills between the children when they started first grade. The differences were related to the home language of the first graders in the English medium schools, as well as the type of school (public vs. private. This article concludes that the numeracy competence of the children from the sample was notably varied in the beginning of their formal schooling, which has implications for teaching in the vastly different classroom populations that are all served by one national curriculum.

  2. Associations of Midlife to Late Life Fatigue With Physical Performance and Strength in Early Old Age

    DEFF Research Database (Denmark)

    Mänty, Minna Regina; Kuh, Diana; Cooper, Rachel

    2015-01-01

    OBJECTIVES: To examine associations of fatigue in midlife and later life with physical performance and strength in early old age. METHODS: Data on approximately 1800 men and women from the UK Medical Research Council National Survey of Health and Development with data on fatigue at ages 43 and 60...... points. These associations were robust and were maintained after adjustment for a range of covariates including physical activity and health status. CONCLUSIONS: Reports of frequent fatigue were associated with poorer physical performance in early old age, especially if sustained from midlife to later...... to 64 years were used. Fatigue was defined as perceived tiredness and was assessed prospectively at ages 43 and 60 to 64 years. At both ages, participants were categorized as having no, occasional, or frequent fatigue. Physical performance and strength were measured at age 60 to 64 years using four...

  3. Perinatal morbidity and mortality in early-onset fetal growth restriction : cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

    NARCIS (Netherlands)

    Lees, C.; Marlow, N.; Arabin, B.; Bilardo, C. M.; Brezinka, C.; Derks, J. B.; Duvekot, J.; Frusca, T.; Diemert, A.; Ferrazzi, E.; Ganzevoort, W.; Hecher, K.; Martinelli, P.; Ostermayer, E.; Papageorghiou, A. T.; Schlembach, D.; Schneider, K. T. M.; Thilaganathan, B.; Todros, T.; van Wassenaer-Leemhuis, A.; Valcamonico, A.; Visser, G. H. A.; Wolf, H.

    2013-01-01

    ObjectivesFew data exist for counseling and perinatal management of women after an antenatal diagnosis of early-onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching. The objective of this study was to describe

  4. Effect of early experience and adaptation period on voluntary intake, digestion, and growth in Barbarine lambs given tannin-containing (Acacia cyanophylla Lindl. foliage) or tannin-free (oaten hay) diets

    Energy Technology Data Exchange (ETDEWEB)

    Ben Salem, H. [Institut National de la Recherche Agronomique de Tunisie, Laboratoire des Productions Animales et Fourrageres, Ariana (Tunisia)]. E-mail: bensalem.hichem@iresa.agrinet.tn; Nefzaouia, A.; Ben Salem, I. [Institut National de la Recherche Agronomique de Tunisie, Laboratoire des Productions Animales et Fourrageres, Ariana (Tunisia); Makkar, H.P.S. [Animal Production and Health Section, Joint FAO/IAEA Division, International Atomic Energy Agency, Vienna (Austria); Hochlef, H. [Institut National de la Recherche Agronomique de Tunisie, Laboratoire des Productions Animales et Fourrageres, Ariana (Tunisia); Ecole Superieure d' Agriculture de Mateur, Mateur (Tunisia); Ben Salem, L. [Office de l' Elevage et des Paturages, Tunis (Tunisia)

    2005-08-19

    Our objective was to determine whether experience early in life and adaptation time (up to 72 days) to tannin-rich diets affect feed intake, digestion, nitrogen balance, and growth in Barbarine lambs given tannin-containing (Acacia cyanophylla Lindl., acacia) or tannin-free (oaten hay) diets later in life. Twelve experienced lambs (live-weight, LW: 13.2 {+-} 2.0 kg) were divided into two equal groups. Each group received air-dried acacia (tannin-containing diet) or oaten hay (hay, tannin free-diet) ad libitum. Twelve other inexperienced lambs (LW 12.3 {+-} 2.5 kg) were also divided into two equal groups. Each group received one of the above two diets. All animals were 4 months old at the start of this experiment and were supplemented with 300 g concentrate. To investigate the carry-over effect of tannins, the acacia-diet was removed on day 73, thus all lambs received thereafter the hay-diet for a further 24 days before starting a 6-day faecal collection period. Irrespective to early experience and adaptation time, the nutritive value of hay-diet was higher than that of acacia-diet and consequently lambs given hay performed better than those receiving acacia (P = 0.0001). Animals exposed to tannins early in life exhibited higher digestible crude protein intake (P = 0.0389), retained more N (P = 0.0963) and excreted more allantoin in urine (P = 0.0248) than the inexperienced lambs. Except plasma urea (P = 0.2923), the adaptation period to experimental diets affected significantly all measured parameters (P 0.0001). Animals adapted to diets for only 6 days exhibited the lowest acacia or hay intake and the highest diet digestibility compared to those adapted to these diets for 24, 48 or 72 days. Weight losses of inexperienced lambs adapted to acacia-diet for 6 days were associated with negative nitrogen balance. Sheep which received the acacia-diet, followed by the hay diet, had similar hay intake, diet digestibility, N balance and growth rate as compared to those

  5. Effect of early experience and adaptation period on voluntary intake, digestion, and growth in Barbarine lambs given tannin-containing (Acacia cyanophylla Lindl. foliage) or tannin-free (oaten hay) diets

    International Nuclear Information System (INIS)

    Ben Salem, H.; Nefzaouia, A.; Ben Salem, I.; Makkar, H.P.S.; Hochlef, H.; Ben Salem, L.

    2005-01-01

    Our objective was to determine whether experience early in life and adaptation time (up to 72 days) to tannin-rich diets affect feed intake, digestion, nitrogen balance, and growth in Barbarine lambs given tannin-containing (Acacia cyanophylla Lindl., acacia) or tannin-free (oaten hay) diets later in life. Twelve experienced lambs (live-weight, LW: 13.2 ± 2.0 kg) were divided into two equal groups. Each group received air-dried acacia (tannin-containing diet) or oaten hay (hay, tannin free-diet) ad libitum. Twelve other inexperienced lambs (LW 12.3 ± 2.5 kg) were also divided into two equal groups. Each group received one of the above two diets. All animals were 4 months old at the start of this experiment and were supplemented with 300 g concentrate. To investigate the carry-over effect of tannins, the acacia-diet was removed on day 73, thus all lambs received thereafter the hay-diet for a further 24 days before starting a 6-day faecal collection period. Irrespective to early experience and adaptation time, the nutritive value of hay-diet was higher than that of acacia-diet and consequently lambs given hay performed better than those receiving acacia (P = 0.0001). Animals exposed to tannins early in life exhibited higher digestible crude protein intake (P = 0.0389), retained more N (P = 0.0963) and excreted more allantoin in urine (P = 0.0248) than the inexperienced lambs. Except plasma urea (P = 0.2923), the adaptation period to experimental diets affected significantly all measured parameters (P 0.0001). Animals adapted to diets for only 6 days exhibited the lowest acacia or hay intake and the highest diet digestibility compared to those adapted to these diets for 24, 48 or 72 days. Weight losses of inexperienced lambs adapted to acacia-diet for 6 days were associated with negative nitrogen balance. Sheep which received the acacia-diet, followed by the hay diet, had similar hay intake, diet digestibility, N balance and growth rate as compared to those offered

  6. Sex is not everything: the role of gender in early performance of a fundamental laparoscopic skill.

    Science.gov (United States)

    Kolozsvari, Nicoleta O; Andalib, Amin; Kaneva, Pepa; Cao, Jiguo; Vassiliou, Melina C; Fried, Gerald M; Feldman, Liane S

    2011-04-01

    Existing literature on the acquisition of surgical skills suggests that women generally perform worse than men. This literature is limited by looking at an arbitrary number of trials and not adjusting for potential confounders. The objective of this study was to evaluate the impact of gender on the learning curve for a fundamental laparoscopic task. Thirty-two medical students performed the FLS peg transfer task and their scores were plotted to generate a learning curve. Nonlinear regression was used to estimate learning plateau and learning rate. Variables that may affect performance were assessed using a questionnaire. Innate visual-spatial abilities were evaluated using tests for spatial orientation, spatial scanning, and perceptual abilities. Score on first peg transfer attempt, learning plateau, and learning rate were compared for men and women using Student's t test. Innate abilities were correlated to simulator performance using Pearson's coefficient. Multivariate linear regression was used to investigate the effect of gender on early laparoscopic performance after adjusting for factors found significant on univariate analysis. Statistical significance was defined as P men and 13 women participated in the study; 30 were right-handed, 12 reported high interest in surgery, and 26 had video game experience. There were no differences between men and women in initial peg transfer score, learning plateau, or learning rate. Initial peg transfer score and learning rate were higher in subjects who reported having a high interest in surgery (P = 0.02, P = 0.03). Initial score also correlated with perceptual ability score (P = 0.03). In multivariate analysis, only surgical interest remained a significant predictor of score on first peg transfer (P = 0.03) and learning rate (P = 0.02), while gender had no significant relationship to early performance. Gender did not affect the learning curve for a fundamental laparoscopic task, while interest in surgery and perceptual

  7. Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth

    Energy Technology Data Exchange (ETDEWEB)

    De Nicola, Elena [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy); Meric, Suereyya [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Gallo, Marialuisa [Campania Regional Agency for Environmental Protection (ARPAC), I-80143 Naples (Italy); Iaccarino, Mario [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy); Della Rocca, Claudio [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Lofrano, Giusy [Department of Civil Engineering, Salerno University, I-84084 Fisciano (Italy); Russo, Teresa [Campania Regional Agency for Environmental Protection (ARPAC), I-80143 Naples (Italy); Pagano, Giovanni [Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples (Italy)]. E-mail: gbpagano@tin.it

    2007-03-15

    Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels {>=}1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% 'viable' (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. - Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects.

  8. Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth

    International Nuclear Information System (INIS)

    De Nicola, Elena; Meric, Suereyya; Gallo, Marialuisa; Iaccarino, Mario; Della Rocca, Claudio; Lofrano, Giusy; Russo, Teresa; Pagano, Giovanni

    2007-01-01

    Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels ≥1 mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3 mg/L when control cultures displayed suboptimal quality, i.e. <70% 'viable' (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. - Vegetable tannin and synthetic tannins were moderately toxic or displayed hormetic effects in sea urchins and in algae. Re-defining control quality is needed for evaluating hormetic effects

  9. Omega-3 polyunsaturated fatty acids provided during embryonic development improve the growth performance and welfare of Muscovy ducks (Cairina moschata).

    Science.gov (United States)

    Baéza, E; Chartrin, P; Bordeau, T; Lessire, M; Thoby, J M; Gigaud, V; Blanchet, M; Alinier, A; Leterrier, C

    2017-09-01

    The welfare of ducks can be affected by unwanted behaviors such as excessive reactivity and feather pecking. Providing long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA) during gestation and early life has been shown to improve the brain development and function of human and rodent offspring. The aim of this study was to test whether the pecking behavior of Muscovy ducks during rearing could be reduced by providing LC n-3 PUFA during embryonic and/or post-hatching development of ducklings. Enrichment of eggs, and consequently embryos, with LC n-3 PUFA was achieved by feeding female ducks (n-3F) a diet containing docosahexaenoic (DHA) and linolenic acids (microalgae and linseed oil). A control group of female ducks (CF) was fed a diet containing linoleic acid (soybean oil). Offspring from both groups were fed starter and grower diets enriched with DHA and linolenic acid or only linoleic acid, resulting in four treatment groups with 48 ducklings in each. Several behavioral tests were performed between 1 and 3 weeks of age to analyze the adaptation ability of ducklings. The growth performance, time budget, social interactions, feather growth, and pecking behavior of ducklings were recorded regularly during the rearing period. No significant interaction between maternal and duckling feeding was found. Ducklings from n-3F ducks had a higher body weight at day 0, 28, and 56, a lower feed conversion ratio during the growth period, and lower reactivity to stress than ducklings from CF ducks. Ducklings from n-3F ducks also exhibited a significantly reduced feather pecking frequency at 49 and 56 days of age and for the whole rearing period. Moreover, consumption of diets enriched with n-3 PUFA during the starter and grower post-hatching periods significantly improved the tibia mineralization of ducklings and the fatty acid composition of thigh muscles at 84 days of age by increasing the n-3 FA content. © 2017 Poultry Science Association Inc.

  10. Explaining African Growth Performance: A Production-Frontier Approach

    OpenAIRE

    Romain Houssa; Oleg Badunenko; Daniel J. Henderson

    2010-01-01

    This paper employs a production frontier approach that allows distinguishing technologic progress from efficiency development. Data on 35 African countries in 1970-2007 show that efficiency losses have constrained growth in Africa while technology progress has played a marginal growth enhancing role in the region. Moreover, physical and human capital accumulation are the main factors that drive productivity growth at the country level. Examining the outcomes of successful countries suggests t...

  11. Optimising growth in phenylketonuria

    DEFF Research Database (Denmark)

    Dokoupil, Katharina; Gokmen-Ozel, Hulya; Lammardo, Anna Maria

    2012-01-01

    populations. We reviewed the literature searching for evidence regarding PKU and growth as well as possible links between dietary management of PKU and growth. The search retrieved only limited evidence on the effect of PKU and its dietary management on growth. Physical development in PKU remains an under....... Protein requirements in dietary management of PKU are met mostly from Phe-free protein substitutes with the intake of natural protein restricted to patient tolerance. Several reports have suggested that growth in early childhood in PKU is sub-optimal, relative to non-PKU control groups or reference...

  12. Lettuce (Lactuca sativa L. var. Sucrine) growth performance in complemented aquaponic solution outperforms hydroponics

    NARCIS (Netherlands)

    Delaide, Boris; Goddek, Simon; Gott, James; Soyeurt, Hélène; Jijakli, M.H.

    2016-01-01

    Plant growth performance is optimized under hydroponic conditions. The comparison between aquaponics and hydroponics has attracted considerable attention recently, particularly regarding plant yield. However, previous research has not focused on the potential of using aquaponic solution

  13. Effects of dietary hawthorn extract on growth performance, immune responses, growth- and immune-related genes expression of juvenile golden pompano (Trachinotus ovatus) and its susceptibility to Vibrio harveyi infection.

    Science.gov (United States)

    Tan, Xiaohong; Sun, Zhenzhu; Huang, Zhong; Zhou, Chuanpeng; Lin, Heizhao; Tan, Lianjie; Xun, Pengwei; Huang, Qian

    2017-11-01

    The present study was conducted to investigate the effects of dietary hawthorn extract (HTE) supplementation on growth performance, immune responses, hepatic antioxidant abilities, growth- and immune-related and heat shock protein genes expression and resistance to the pathogen Vibrio harveyi in Trachinotus ovatus. A basal diet supplemented with HTE at 0 (Diet 1), 0.50 (Diet 2), 1.00 (Diet 3), 2.00 (Diet 4), 4.00 (Diet 5) and 10.00 (Diet 6) g kg -1 were fed to golden pompano for 8 weeks. The highest final body weight, weight gain rate, specific growth rate, feed efficiency ratio and protein efficiency rate were observed in fish fed Diet 2 (P Vibrio harveyi, significant higher post-challenge survival was observed in fish fed Diet 2 and Diet 3 than the control group (P growth-related genes (IGF-I and IGF-II) were significantly up-regulated in fish fed HTE supplement (P growth performance and growth-related genes expression, strengthen immunity, and improve hepatic antioxidative abilities and resistance to Vibrio harveyi infection. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Early Learning and Educational Technology Policy Brief

    Science.gov (United States)

    Lee, Joan

    2016-01-01

    Recognizing the growth of technology use in early learning settings, the U.S. Department of Education and U.S. Department of Health and Human Services collaborated in the development of the "Early Learning and Educational Technology Policy Brief" to promote developmentally appropriate use of technology in homes and early learning…

  15. Interacting effects of warming and drought on regeneration and early growth of Acer pseudoplatanus and A. platanoides.

    Science.gov (United States)

    Carón, M M; De Frenne, P; Brunet, J; Chabrerie, O; Cousins, S A O; De Backer, L; Decocq, G; Diekmann, M; Heinken, T; Kolb, A; Naaf, T; Plue, J; Selvi, F; Strimbeck, G R; Wulf, M; Verheyen, K

    2015-01-01

    Climate change is acting on several aspects of plant life cycles, including the sexual reproductive stage, which is considered amongst the most sensitive life-cycle phases. In temperate forests, it is expected that climate change will lead to a compositional change in community structure due to changes in the dominance of currently more abundant forest tree species. Increasing our understanding of the effects of climate change on currently secondary tree species recruitment is therefore important to better understand and forecast population and community dynamics in forests. Here, we analyse the interactive effects of rising temperatures and soil moisture reduction on germination, seedling survival and early growth of two important secondary European tree species, Acer pseudoplatanus and A. platanoides. Additionally, we analyse the effect of the temperature experienced by the mother tree during seed production by collecting seeds of both species along a 2200-km long latitudinal gradient. For most of the responses, A. platanoides showed higher sensitivity to the treatments applied, and especially to its joint manipulation, which for some variables resulted in additive effects while for others only partial compensation. In both species, germination and survival decreased with rising temperatures and/or soil moisture reduction while early growth decreased with declining soil moisture content. We conclude that although A. platanoides germination and survival were more affected after the applied treatments, its initial higher germination and larger seedlings might allow this species to be relatively more successful than A. pseudoplatanus in the face of climate change. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

  16. Early growth response-1 negative feedback regulates skeletal muscle postprandial insulin sensitivity via activating Ptp1b transcription.

    Science.gov (United States)

    Wu, Jing; Tao, Wei-Wei; Chong, Dan-Yang; Lai, Shan-Shan; Wang, Chuang; Liu, Qi; Zhang, Tong-Yu; Xue, Bin; Li, Chao-Jun

    2018-03-15

    Postprandial insulin desensitization plays a critical role in maintaining whole-body glucose homeostasis by avoiding the excessive absorption of blood glucose; however, the detailed mechanisms that underlie how the major player, skeletal muscle, desensitizes insulin action remain to be elucidated. Herein, we report that early growth response gene-1 ( Egr-1) is activated by insulin in skeletal muscle and provides feedback inhibition that regulates insulin sensitivity after a meal. The inhibition of the transcriptional activity of Egr-1 enhanced the phosphorylation of the insulin receptor (InsR) and Akt, thus increasing glucose uptake in L6 myotubes after insulin stimulation, whereas overexpression of Egr-1 decreased insulin sensitivity. Furthermore, deletion of Egr-1 in the skeletal muscle improved systemic insulin sensitivity and glucose tolerance, which resulted in lower blood glucose levels after refeeding. Mechanistic analysis demonstrated that EGR-1 inhibited InsR phosphorylation and glucose uptake in skeletal muscle by binding to the proximal promoter region of protein tyrosine phosphatase-1B (PTP1B) and directly activating transcription. PTP1B knockdown largely restored insulin sensitivity and enhanced glucose uptake, even under conditions of EGR-1 overexpression. Our results indicate that EGR-1/PTP1B signaling negatively regulates postprandial insulin sensitivity and suggest a potential therapeutic target for the prevention and treatment of excessive glucose absorption.-Wu, J., Tao, W.-W., Chong, D.-Y., Lai, S.-S., Wang, C., Liu, Q., Zhang, T.-Y., Xue, B., Li, C.-J. Early growth response-1 negative feedback regulates skeletal muscle postprandial insulin sensitivity via activating Ptp1b transcription.

  17. Effect of silver nanoparticles on growth performance, metabolism and microbial profile of broiler chickens

    DEFF Research Database (Denmark)

    Pineda, Lane Manalili; Chwalibog, André; Sawosz, Ewa

    2012-01-01

    and intestinal content were collected to evaluate the effects of AgNano on plasma concentration of immunoglobulins and the intestinal microflora, respectively. The provision of water solutions containing different concentrations of AgNano had no effect on postnatal growth performance and the energy metabolism...... (IgG) in the blood plasma of broilers supplemented with AgNano decreased at day 36 (p = 0.012). The results demonstrated that AgNano affects N utilisation and plasma IgG concentration; however, it does not influence the microbial populations in the digestive tract, the energy metabolism and growth...

  18. Effects of stocking density on growth performance, feather growth, intestinal development, and serum parameters of geese.

    Science.gov (United States)

    Yin, L Y; Wang, Z Y; Yang, H M; Xu, L; Zhang, J; Xing, H

    2017-09-01

    This experiment was conducted to evaluate the effects of stocking density on the growth performance, feather growth, intestinal development, and serum parameters of geese. In total, 336 healthy, 28-day-old, male Yangzhou goslings were randomly allotted to 30 plastic wire-floor pens according to 5 stocking densities (2, 3, 4, 5 and 6 birds/m2). The results showed that with the stocking density increased from 2 birds/m2 to 6 birds/m2, the body weights of geese at 42 d (P density was increased to 6 birds/m2. Serum concentrations of alkaline phosphatase (P = 0.013) and triiodothyronine (P density increased. The serum thyroxine concentration of geese from the 6 birds/m2 group was lower than that of geese from the other groups (P density will adversely influence thyroid function and the developments of the body weight, body size, feathers, and small intestine. Under our experimental conditions, we recommend that the stocking density of geese should be kept to 5 or fewer birds/m2 to avoid the negative effects of high stocking density on geese. © 2017 Poultry Science Association Inc.

  19. Monitoring Million Trees LA: Tree performance during the early years and future benefits

    Science.gov (United States)

    E. Gregory McPherson

    2014-01-01

    Million Trees LA (MTLA) is one of several large-scale mayoral tree planting initiatives striving to create more livable cities through urban forestry. This study combined field sampling of tree survival and growth with numerical modeling of future benefits to assess performance of MTLA plantings. From 2006 to 2010 MTLA planted a diverse mix of 91,786 trees....

  20. Can reactivity to stress and family environment explain memory and executive function performance in early and middle childhood?

    Science.gov (United States)

    Piccolo, Luciane da Rosa; Salles, Jerusa Fumagalli de; Falceto, Olga Garcia; Fernandes, Carmen Luiza; Grassi-Oliveira, Rodrigo

    2016-01-01

    According to the literature, children's overall reactivity to stress is associated with their socioeconomic status and family environment. In turn, it has been shown that reactivity to stress is associated with cognitive performance. However, few studies have systematically tested these three constructs together. To investigate the relationship between family environment, salivary cortisol measurements and children's memory and executive function performance. Salivary cortisol levels of 70 children aged 9 or 10 years were measured before and after performing tasks designed to assess memory and executive functions. Questionnaires on socioeconomic issues, family environment and maternal psychopathologies were administered to participants' families during the children's early childhood and again when they reached school age. Data were analyzed by calculating correlations between variables and conducting hierarchical regression. High cortisol levels were associated with poorer working memory and worse performance in tasks involving executive functions, and were also associated with high scores for maternal psychopathology (during early childhood and school age) and family dysfunction. Family environment variables and changes in cortisol levels explain around 20% of the variance in performance of cognitive tasks. Family functioning and maternal psychopathology in early and middle childhood and children's stress levels were associated with children's working memory and executive functioning.

  1. Longitudinal analysis of receptive vocabulary growth in young Spanish English-speaking children from migrant families.

    Science.gov (United States)

    Jackson, Carla Wood; Schatschneider, Christopher; Leacox, Lindsey

    2014-01-01

    The authors of this study described developmental trajectories and predicted kindergarten performance of Spanish and English receptive vocabulary acquisition of young Latino/a English language learners (ELLs) from socioeconomically disadvantaged migrant families. In addition, the authors examined the extent to which gender and individual initial performance in Spanish predict receptive vocabulary performance and growth rate. The authors used hierarchical linear modeling of 64 children's receptive vocabulary performance to generate growth trajectories, predict performance at school entry, and examine potential predictors of rate of growth. The timing of testing varied across children. The ELLs (prekindergarten to 2nd grade) participated in 2-5 testing sessions, each 6-12 months apart. The ELLs' average predicted standard score on an English receptive vocabulary at kindergarten was nearly 2 SDs below the mean for monolingual peers. Significant growth in the ELLs' receptive vocabulary was observed between preschool and 2nd grade, indicating that the ELLs were slowly closing the receptive vocabulary gap, although their average score remained below the standard score mean for age-matched monolingual peers. The ELLs demonstrated a significant decrease in Spanish receptive vocabulary standard scores over time. Initial Spanish receptive vocabulary was a significant predictor of growth in English receptive vocabulary. High initial Spanish receptive vocabulary was associated with greater growth in English receptive vocabulary and decelerated growth in Spanish receptive vocabulary. Gender was not a significant predictor of growth in either English or Spanish receptive vocabulary. ELLs from low socioeconomic backgrounds may be expected to perform lower in English compared with their monolingual English peers in kindergarten. Performance in Spanish at school entry may be useful in identifying children who require more intensive instructional support for English vocabulary

  2. Growth dynamics of tree-line and lake-shore Scots pine (Pinus sylvestris L. in the central Scandinavian Mountains during the Medieval Climate Anomaly and the early Little Ice Age

    Directory of Open Access Journals (Sweden)

    Hans W Linderholm

    2014-05-01

    Full Text Available Trees growing at their altitudinal or latitudinal distribution in Fennoscandia have been widely used to reconstruct warm season temperatures, and the region hosts some of the world’s longest tree-ring chronologies. These multi-millennial long chronologies have mainly been built from tree remains found in lakes (subfossil wood from lake-shore trees. We used a unique dataset of Scots pine tree-ring data collected from wood remains found on a mountain slope in the central Scandinavian Mountains, yielding a chronology spanning over much of the last 1200 years. This data was compared with a local subfossil wood chronology with the aim to 1 describe growth variability in two environments during the Medieval Climate Anomaly (MCA and the early Little Ice Age (LIA, and 2 investigate differences in growth characteristics during these contrasting periods. It was shown that the local tree-line during both the MCA and early LIA was almost 150 m higher that at present. Based on living pines from the two environments, tree-line pine growth was strongly associated with mid-summer temperatures, while the lake-shore trees showed an additional response to summer precipitation. During the MCA, regarded to be a period of favourable climate in the region, the tree-ring data from both environments showed strong coherency and moderate growth variability. In the early LIA, the two chronologies were less coherent, with the tree-line chronology showing more variability, suggesting different growth responses in the two environments during this period of less favourable growing conditions. Our results indicate that tree-ring width chronologies mainly based on lake-shore trees may need to be re-evaluated.

  3. Early vocabulary development in children with bilateral cochlear implants.

    Science.gov (United States)

    Välimaa, Taina; Kunnari, Sari; Laukkanen-Nevala, Päivi; Lonka, Eila

    2018-01-01

    Children with unilateral cochlear implants (CIs) may have delayed vocabulary development for an extended period after implantation. Bilateral cochlear implantation is reported to be associated with improved sound localization and enhanced speech perception in noise. This study proposed that bilateral implantation might also promote early vocabulary development. Knowledge regarding vocabulary growth and composition in children with bilateral CIs and factors associated with it may lead to improvements in the content of early speech and language intervention and family counselling. To analyse the growth of early vocabulary and its composition during the first year after CI activation and to investigate factors associated with vocabulary growth. The participants were 20 children with bilateral CIs (12 boys; eight girls; mean age at CI activation = 12.9 months). Vocabulary size was assessed with the Finnish version of the MacArthur Communicative Development Inventories (CDI) Infant Form and compared with normative data. Vocabulary composition was analysed in relation to vocabulary size. Growth curve modelling was implemented using a linear mixed model to analyse the effects of the following variables on early vocabulary growth: time, gender, maternal education, residual hearing with hearing aids, age at first hearing aid fitting and age at CI activation. Despite clear vocabulary growth over time, children with bilateral CIs lagged behind their age norms in receptive vocabulary during the first 12 months after CI activation. In expressive vocabulary, 35% of the children were able to catch up with their age norms, but 55% of the children lagged behind them. In receptive and expressive vocabularies of 1-20 words, analysis of different semantic categories indicated that social terms constituted the highest proportion. Nouns constituted the highest proportion in vocabularies of 101-400 words. The proportion of verbs remained below 20% and the proportion of function words and

  4. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort

    NARCIS (Netherlands)

    Leffelaar, Evelien R.; Vrijkotte, Tanja G. M.; van Eijsden, Manon

    2010-01-01

    Low vitamin D levels during pregnancy may account for reduced fetal growth and for altered neonatal development. The present study explored the association between maternal vitamin D status measured early in pregnancy and birth weight, prevalence of small-for-gestational-age (SGA) infants and

  5. Mathematical and numerical modeling of early atherosclerotic lesions***

    Directory of Open Access Journals (Sweden)

    Raoult Annie

    2010-12-01

    Full Text Available This article is devoted to the construction of a mathematical model describing the early formation of atherosclerotic lesions. The early stage of atherosclerosis is an inflammatory process that starts with the penetration of low density lipoproteins in the intima and with their oxidation. This phenomenon is closely linked to the local blood flow dynamics. Extending a previous work [5] that was mainly restricted to a one-dimensional setting, we couple a simple lesion growth model relying on the biomolecular process that takes place in the intima with blood flow dynamics and mass transfer. We perform numerical simulations on a two-dimensional geometry taken from [6,7] that mimicks a carotid artery deformed by a perivascular cast and we compare the numerical results with experimental data.

  6. Effects of spacing on early growth rate and carbon sequestration in Pinus brut ia Ten. plantations

    Energy Technology Data Exchange (ETDEWEB)

    Erkan, N.; Aydin, A.C.

    2016-07-01

    Aim of the study: The aim of this study was to analyze the effects of initial spacing on early growth and carbon sequestration rates in Turkish red pine plantations up to 12 years old, established with improved seeds and deep soil cultivation. Area of study: The study was conducted on experimental sites established in two locations within the Turkish red pine natural distribution areas, namely Du acı and Nebiler close to Antalya city. Material and methods: Data were collected from the experimental sites established as a Nelder design (fan-shaped), with 72 rays and 18 arcs (circles), and trees were planted (almost square) at distances ranging from 1.15 to 4.77 m. Soil type of both sites is loamy, with soil clay content varying between 70-87% in Duacı and 51-70% in Nebiler. Soils are deep being more than one m in both sites, but rockier in Nebiler, providing better soil drainage in this site. Main results: The results showed that mean total height was greater at closer spacing than those of wider spacing until age eight. Growth retardation at wider spacing in early years may be related to water loss due to evaporation in hot summer days and weed suppression. Following the age eight, competition among trees appears to be the major factor reducing the growth and carbon fixation. Diameter at breast height and individual tree volume increased, while stand volume, mean annual volume increment and annual carbon storage per hectare considerably decreased for wider spacing. Our results suggest that in order to obtain higher yield and more carbon fixation, short rotation plantations should initially be established in closer spacing, followed by thinning in subsequent years as required by silvicultural concerns. In this context, spacing 3.0 × 1.0 m or 3.0 × 1.5 m (3.0 and 4.5 m2 growing area per tree, respectively) seems to be more plausible, providing farm machinery for maintenance and harvesting. We also found that mean annual volume increment per unit area can be

  7. Characterisation of foreign object damage (FOD) and early fatigue crack growth in laser shock peened Ti-6Al-4V aerofoil specimens

    Energy Technology Data Exchange (ETDEWEB)

    Spanrad, S. [Mechanical Behaviour of Materials Laboratory, Department of Mechanical and Design Engineering, University of Portsmouth (United Kingdom); Tong, J., E-mail: jie.tong@port.ac.uk [Mechanical Behaviour of Materials Laboratory, Department of Mechanical and Design Engineering, University of Portsmouth (United Kingdom)

    2011-02-25

    Research highlights: {yields} A study of deformation in a generic LSPed aerofoil specimen subjected to high speed head-on and 45 deg. impacts, and subsequently fatigue loading. {yields} Characterisation of damage features considering geometry of the projectile, impact angle and impact velocity. {yields} Onset and early crack growth due to FOD in LSPed samples compared to those without LSP subjected to cubical impacts under simulated service loading conditions. - Abstract: Foreign object damage (FOD) has been identified as one of the primary life limiting factors for fan and compressor blades, with the leading edge of aerofoils particularly susceptible to such damage. In this study, a generic aerofoil specimen of Ti-6Al-4V alloy was used. The specimens were treated by laser shock peening (LSP) to generate compressive residual stresses in the leading edge region prior to impact. FOD was simulated by firing a cubical projectile at the leading edge using a laboratory gas gun at 200 m/s, head-on; and at 250 m/s, at an angle of 45 deg. The specimens were then subjected to 4-point bend fatigue testing under high cycle (HCF), low cycle (LCF) and combined LCF and HCF loading conditions. Scanning electron microscopy (SEM) was used to characterise the damage features due to FOD. Crack initiation and early crack growth due to FOD and subsequent fatigue growth were examined in detail. The results were compared between the two impact conditions; and with those from samples without LSP treatment as well as those impacted with spherical projectiles. The results seem to suggest that LSP has improved the crack growth resistance post FOD. Delayed onset of crack initiation was observed in LSPed samples compared to those without LSP under similar loading conditions. Damage features depend on the geometry of the projectile, the impact angle as well as the impact velocity.

  8. Photobiostimulation effects on germination and early growth of wheat seeds (Triticum aestivum L) produced by a semiconductor laser with λ=980nm

    International Nuclear Information System (INIS)

    Michtchenko, A.; Hernandez, M.

    2009-01-01

    The effect of the exposure of wheat (Triticum aestivum L) seeds to a IR laser radiation with λ=980nm produced by a semiconductor laser on germination and early growth had been studied under laboratory conditions. Seeds were irradiated to one of two laser intensities 15 mWcm - ''2 or 30 mWcm -2 for different periods of time 30, 60 or 120 s. Seeds exposed to a light intensity of 15mWcm -2 and an exposition time of 30 s. showed an increase on the percentage of seeds germinated normally while the percentage of seeds germinated abnormally decreased. At the same time there is a stimulation effect on the growth of the stem and on the growth of the root of 10% on wheat seedlings over control seedlings. Significant differences (ρ < 0.001) were observed between the control and the above treatment. (Author)

  9. EFFECTS OF DIFFERENT TYPES OF FEED ON GROWTH, SURVIVAL AND DIGESTIVE ENZYME ACTIVITY OF EARLY JUVENILE-STAGE MARBLE GOBY, Oxyeleotris marmoratus

    Directory of Open Access Journals (Sweden)

    Muhammad Darwis

    2008-06-01

    Full Text Available The stable mass seed production technique of marble goby, Oxyeleotris marmoratus has not yet been established due to high mortality occurring on the early juvenile stage and/or after 40 days after hatching (d AH. In order to establish the mass seed production technique, O. marmoratus juveniles of 40 d AH were reared for 60 days to determine growth, survival and digestive enzyme activity at different types of feed (trash fish, artificial feed and Artemia sp. nauplii. Specific growth rate (5.32 and survival rate (91.3% in juveniles fed Artemia sp. nauplii showed significantly higher (P<0.05 than those of juveniles fed trash fish and artificial feed. At the end of the experiment, the mean specific trypsin, amylase and lipase activities of juveniles fed Artemia sp. nauplii were recorded as 0.04 mU mg protein-1m-1, 0.114 mg maltose mg protein-1h-1 and 9.58 m Units, respectively, and they were significantly higher than those of juveniles fed trash fish and artificial feed. In the present study it was shown that O. marmoratus early juveniles had more efficient digestibility and absorption the nutrient when fed with Artemia.

  10. Early-in-life thermal performance of UO2--PuO2 fast reactor fuel

    International Nuclear Information System (INIS)

    Baker, R.B.; Leggett, R.D.

    1979-01-01

    Results from the combined analyses of two thermal performance tests, HEDL P-19 and HEDL P-20 are described. The tests were designed to provide data on the power required to cause incipient fuel melting early in life under conditions prototypic of FFTF driver fuel pins and similar FBR fuel systems

  11. Defects in silicon effect on device performance and relationship to crystal growth conditions

    Science.gov (United States)

    Jastrzebski, L.

    1985-01-01

    A relationship between material defects in silicon and the performance of electronic devices will be described. A role which oxygen and carbon in silicon play during the defects generation process will be discussed. The electronic properties of silicon are a strong function of the oxygen state in the silicon. This state controls mechanical properties of silicon efficiency for internal gettering and formation of defects in the device's active area. In addition, to temperature, time, ambience, and the cooling/heating rates of high temperature treatments, the oxygen state is a function of the crystal growth process. The incorporation of carbon and oxygen into silicon crystal is controlled by geometry and rotation rates applied to crystal and crucible during crystal growths. Also, formation of nucleation centers for oxygen precipitation is influenced by the growth process, although there is still a controversy which parameters play a major role. All these factors will be reviewed with special emphasis on areas which are still ambiguous and controversial.

  12. The performance studies of DKDP crystals grown by a rapid horizontal growth method

    Science.gov (United States)

    Xie, Xiaoyi; Qi, Hongji; Wang, Bin; Wang, Hu; Chen, Duanyang; Shao, Jianda

    2018-04-01

    A deuterated potassium dihydrogen phosphate (DKDP) crystal with about 70% deuterium level was grown by a rapid horizontal growth method with independent design equipment, which includes a continuous filtration system. The cooling program during crystal growth was designed according to a self-developed software to catch the size of growing crystal in real time. The crystal structure, optical performance and laser induced damage threshold (LIDT) of this DKDP crystal were investigated in this paper. The deuterium concentration of the crystal was confirmed by the neutron diffraction technique, which was effective and available in determining a complete range of deuteration level. The dielectric property was measured to evaluate the perfection of the lattice. The transmittance and LIDT were carried out further to evaluate the optical and functional properties of this DKDP crystal grown in the rapid horizontal growth technique. All of the detailed characterization for DKDP figured out that the 70% deuterated KDP crystal grown in this way had relatively good qualities.

  13. Growth trajectories of alcohol information processing and associations with escalation of drinking in early adolescence.

    Science.gov (United States)

    Colder, Craig R; O'Connor, Roisin M; Read, Jennifer P; Eiden, Rina D; Lengua, Liliana J; Hawk, Larry W; Wieczorek, William F

    2014-09-01

    This longitudinal study provided a comprehensive examination of age-related changes in alcohol outcome expectancies, subjective evaluation of alcohol outcomes, and automatic alcohol associations in early adolescence. A community sample (52% female, 75% White/non-Hispanic) was assessed annually for 3 years (mean age at the first assessment = 11.6 years). Results from growth modeling suggested that perceived likelihood of positive outcomes increased and that subjective evaluations of these outcomes were more positive with age. Perceived likelihood of negative outcomes declined with age. Automatic alcohol associations were assessed with an Implicit Association Task (IAT), and were predominantly negative, but these negative associations weakened with age. High initial levels of perceived likelihood of positive outcomes at age 11 were associated with escalation of drinking. Perceived likelihood of negative outcomes was associated with low risk for drinking at age 11, but not with changes in drinking. Increases in positive evaluations of positive outcomes were associated with increases in alcohol use. Overall, findings suggest that at age 11, youth maintain largely negative attitudes and perceptions about alcohol, but with the transition into adolescence, there is a shift toward a more neutral or ambivalent view of alcohol. Some features of this shift are associated with escalation of drinking. Our findings point to the importance of delineating multiple aspects of alcohol information processing for extending cognitive models of alcohol use to the early stages of drinking.

  14. Guided Growth of Horizontal ZnSe Nanowires and their Integration into High-Performance Blue-UV Photodetectors.

    Science.gov (United States)

    Oksenberg, Eitan; Popovitz-Biro, Ronit; Rechav, Katya; Joselevich, Ernesto

    2015-07-15

    Perfectly aligned horizontal ZnSe nano-wires are obtained by guided growth, and easily integrated into high-performance blue-UV photodetectors. Their crystal phase and crystallographic orientation are controlled by the epitaxial relations with six different sapphire planes. Guided growth paves the way for the large-scale integration of nanowires into optoelectronic devices. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Enhancement of growth performance and hematological changes in rainbow trout (Onchorhynchus mykiss alevins fed with Bifidobacterium bacteria

    Directory of Open Access Journals (Sweden)

    Javad Sahandi

    2017-04-01

    Full Text Available The study of probiotic application as an important rearing strategy was started more than 30 years ago and most of these studies were carried out to increase growth and survival of larvae. Effect of Bifidobacterium animalis PTTC-1631 and B. lactis PTTC-1736 as probiotic supplement has been studied on growth performance and hematological changes on rainbow trout, Oncorhynchus mykiss alevins with initial body weight of 0.583 ± 0.197 g. The commercial diet was supplemented with graded levels of probiotics (1×107, 2×107 and 3×107 CFU g-1 dry feed to obtain 3 sets of experimental diets (T1, T2, andT3 respectively and fed four times a day for 60 days. T1 alevin showed the best growth performance in terms of specific growth rate, weight gain, metabolic growth rate, feed conversion ratio and survival rate. The highest red and white blood cell concentrations were noticed in fish fed T2 and T3 diets, respectively, no significant difference was observed in hemoglobin content. T1 showed the significant elevation of serum biochemical parameters and reduction of cortisol level. The results of present study might suggest likely positive effects of probiotic supplements with concentration of 1×107 CFU g-1 dry feed on growth and hematology on rainbow trout alevins.

  16. Early plant growth and biochemical responses induced by Azospirillum brasilense Sp245 lipopolysaccharides in wheat (Triticum aestivum L.) seedlings are attenuated by procyanidin B2.

    Science.gov (United States)

    Vallejo-Ochoa, Juan; López-Marmolejo, Mariel; Hernández-Esquivel, Alma Alejandra; Méndez-Gómez, Manuel; Suárez-Soria, Laura Nicolasa; Castro-Mercado, Elda; García-Pineda, Ernesto

    2018-03-01

    This study analyzes the effects of procyanidin B2 on early wheat plant growth and plant biochemical responses promoted by lipopolysaccharides (LPS) derived from the rhizobacteria Azospirillum brasilense Sp245. Measurements of leaf, root length, fresh weight, and dry weight showed in vitro plant growth stimulation 4 days after treatment with A. brasilense as well as LPS. Superoxide anion (O 2 ·- ) and hydrogen peroxide (H 2 O 2 ) levels increased in seedling roots treated with LPS (100 μg mL -1 ). The chlorophyll content in leaf decreased while the starch content increased 24 h after treatment in seedling roots. The LPS treatment induced a high increase in total peroxidase (POX) (EC 1.11.1.7) activity and ionically bound cell wall POX content in roots, when compared to respective controls. Early plant growth and biochemical responses observed in wheat seedlings treated with LPS were inhibited by the addition of procyanidin B2 (5 μg mL -1 ), a B type proanthocyanidin (PAC), plant-derived polyphenolic compound with binding properties of LPS. All results suggest first that the ionically bound cell wall POX enzymes could be a molecular target of A. brasilense LPS, and second that the recognition or association of LPS by plant cells is required to activate plant responses. This last event could play a critical role during plant growth regulation by A. brasilense LPS.

  17. Carbonate platform growth and demise offshore Central Vietnam

    DEFF Research Database (Denmark)

    Fyhn, Michael B.W.; Boldreel, Lars Ole; Nielsen, Lars H.

    2013-01-01

    Fault Zone, the Tuy Hoa Carbonate Platform fringes the continental margin between Da Nang and Nha Trang. Here, platform growth initiated during the Early Miocene and continued until Middle Miocene time when regional uplift led to subaerial exposure, termination of platform growth and karstification...... continues on isolated platforms hosting the Paracel Islands farther seawards. The onset of widespread carbonate deposition largely reflects the Early Miocene transgression of the area linked with early post-rift subsidence and the opening of the South China Sea. The mid-Neogene shift in carbonate deposition...

  18. Black hole growth in the early Universe is self-regulated and largely hidden from view.

    Science.gov (United States)

    Treister, Ezequiel; Schawinski, Kevin; Volonteri, Marta; Natarajan, Priyamvada; Gawiser, Eric

    2011-06-15

    The formation of the first massive objects in the infant Universe remains impossible to observe directly and yet it sets the stage for the subsequent evolution of galaxies. Although some black holes with masses more than 10(9) times that of the Sun have been detected in luminous quasars less than one billion years after the Big Bang, these individual extreme objects have limited utility in constraining the channels of formation of the earliest black holes; this is because the initial conditions of black hole seed properties are quickly erased during the growth process. Here we report a measurement of the amount of black hole growth in galaxies at redshift z = 6-8 (0.95-0.7 billion years after the Big Bang), based on optimally stacked, archival X-ray observations. Our results imply that black holes grow in tandem with their host galaxies throughout cosmic history, starting from the earliest times. We find that most copiously accreting black holes at these epochs are buried in significant amounts of gas and dust that absorb most radiation except for the highest-energy X-rays. This suggests that black holes grew significantly more during these early bursts than was previously thought, but because of the obscuration of their ultraviolet emission they did not contribute to the re-ionization of the Universe.

  19. Patterns of Growth in Early Childhood and Infectious Disease and Nutritional Determinants.

    Science.gov (United States)

    Black, Robert E

    2017-01-01

    The physical growth of young children in low- and middle-income countries is reduced compared to international standards. The deviations in growth in both weight and height are greatest in the first 2 years of life and this has serious consequences for child mortality, development, adult stature, and health. The determinants of these patterns of growth faltering include intergenerational factors, such as maternal height, short birth interval, and conditions in pregnancy, including maternal underweight and anemia. These factors contribute to fetal growth restriction and premature delivery, which put many infants on a different growth trajectory. Postnatal exposure to microbes resulting in diarrhea and febrile infectious diseases and poor quality diet further compromise growth. Determinants of growth faltering after birth vary by setting and are not independent of each other. For example, the adverse effects of diarrhea on growth may be mitigated by a high-quality diet. Global estimates suggest that 25% of stunting can be attributed to fetal growth restriction and even more in countries in South Asia with a high prevalence of low birth weight. Infectious diseases may contribute a similar amount and subclinical enteric infections can result in intestinal dysfunction with adverse effects on nutrition and growth. Dietary factors, especially consumption of complementary foods of insufficient quality, have a paramount role in growth faltering in the critical period of infancy. © 2017 Nestec Ltd., Vevey/S. Karger AG, Basel.

  20. A synthesis of radial growth patterns preceding tree mortality

    Science.gov (United States)

    Cailleret, Maxime; Jansen, Steven; Robert, Elisabeth M.R.; Desoto, Lucia; Aakala, Tuomas; Antos, Joseph A.; Beikircher, Barbara; Bigler, Christof; Bugmann, Harald; Caccianiga, Marco; Cada, Vojtech; Camarero, Jesus J.; Cherubini, Paolo; Cochard, Herve; Coyea, Marie R.; Cufar, Katarina; Das, Adrian J.; Davi, Hendrik; Delzon, Sylvain; Dorman, Michael; Gea-Izquierdo, Guillermo; Gillner, Sten; Haavik, Laurel J.; Hartmann, Henrik; Heres, Ana-Maria; Hultine, Kevin R.; Janda, Pavel; Kane, Jeffrey M.; Kharuk, Vyacheslav I.; Kitzberger, Thomas; Klein, Tamir; Kramer, Koen; Lens, Frederic; Levanic, Tom; Calderon, Juan C. Linares; Lloret, Francisco; Lobo-Do-Vale, Raquel; Lombardi, Fabio; Lopez Rodriguez, Rosana; Makinen, Harri; Mayr, Stefan; Meszaros, IIona; Metsaranta, Juha M.; Minunno, Francesco; Oberhuber, Walter; Papadopoulos, Andreas; Peltoniemi, Mikko; Petritan, Any M.; Rohner, Brigitte; Sanguesa-Barreda, Gabriel; Sarris, Dimitrios; Smith, Jeremy M.; Stan, Amanda B.; Sterck, Frank; Stojanovic, Dejan B.; Suarez, Maria L.; Svoboda, Miroslav; Tognetti, Roberto; Torres-Ruiz, Jose M.; Trotsiuk, Volodymyr; Villalba, Ricardo; Vodde, Floor; Westwood, Alana R.; Wyckoff, Peter H.; Zafirov, Nikolay; Martinez-Vilalta, Jordi

    2017-01-01

    Tree mortality is a key factor influencing forest functions and dynamics, but our understanding of the mechanisms leading to mortality and the associated changes in tree growth rates are still limited. We compiled a new pan-continental tree-ring width database from sites where both dead and living trees were sampled (2970 dead and 4224 living trees from 190 sites, including 36 species), and compared early and recent growth rates between trees that died and those that survived a given mortality event. We observed a decrease in radial growth before death in ca. 84% of the mortality events. The extent and duration of these reductions were highly variable (1–100 years in 96% of events) due to the complex interactions among study species and the source(s) of mortality. Strong and long-lasting declines were found for gymnosperms, shade- and drought-tolerant species, and trees that died from competition. Angiosperms and trees that died due to biotic attacks (especially bark-beetles) typically showed relatively small and short-term growth reductions. Our analysis did not highlight any universal trade-off between early growth and tree longevity within a species, although this result may also reflect high variability in sampling design among sites. The intersite and interspecific variability in growth patterns before mortality provides valuable information on the nature of the mortality process, which is consistent with our understanding of the physiological mechanisms leading to mortality. Abrupt changes in growth immediately before death can be associated with generalized hydraulic failure and/or bark-beetle attack, while long-term decrease in growth may be associated with a gradual decline in hydraulic performance coupled with depletion in carbon reserves. Our results imply that growth-based mortality algorithms may be a powerful tool for predicting gymnosperm mortality induced by chronic stress, but not necessarily so for angiosperms and in case of intense drought or

  1. Early growth of typical high-redshift black holes seeded by direct collapse

    Science.gov (United States)

    Latif, Muhammad A.; Volonteri, Marta; Wise, John H.

    2018-06-01

    Understanding the growth of high-redshift massive black holes (MBHs) is a problem of great astrophysical interest. The most luminous quasars at z > 6 are frequently observed but they represent only the tip of the iceberg as the majority of the low-luminosity active galactic nuclei (AGN) population remains undetected. In this study, we perform a radiation hydrodynamics cosmological simulation to study the growth of `normal' black holes in the high-redshift universe. In our simulation, we model the formation of Pop III and Pop II stars along with their chemical, mechanical, and radiative feedback. We consider both UV and X-ray emission from an accreting BH to simulate its radiative feedback. The selected halo has a mass of 3 × 10^{10} M_{⊙} at z = 7.5 and we turn on radiative feedback from a MBH seed of 10^5 M_{⊙} along with in situ star formation at z = 12 when the halo mass reaches well above the atomic cooling limit. We find that the MBH accretes only about 2200 M_{⊙} during 320 Myr and the average mass accretion on to the MBH is a few times 10^{-6} M_{⊙} yr^{-1}. Our results suggest that the stunted growth of MBH is a consequence of supernovae in tandem with MBH feedback which drive large outflows and evacuate the gas from MBH vicinity. This may explain why a population of low-luminosity AGN has not been detected so-far at z > 6; the large contrast between the star formation rate and the MBH accretion rate may make then hard to detect even in upcoming deep surveys.

  2. The effects of different sizes of insoluble grit on growth performance and carcass traits in broiler chickens

    Directory of Open Access Journals (Sweden)

    Abbas Ali Rajabiyan Moghaddam

    2016-04-01

    Full Text Available The present study was conducted to investigate the effects of different sizes of insoluble grit on growth performance and carcass traits in broiler chickens. A total of 200 broilers (Ross 308, 10 days old, were randomly allotted to five experimental equal groups with four replicates of 10 chickens (five male and five female and fed with basal diet + ground wheat (without grit; basal diet + whole wheat (without grit and basal diet contain 1.5% grit of diet with sizes of 2, 3 and 4 mm. Growth performance (evaluated through weight gain, feed intake and feed conversion ratio was determined on day 24 and 42. Also, carcass traits (relative weights of carcass, breast, thigh, liver, heart, gizzard and intestine and intestine length were assessed on day 42. Weight gains and feed conversion ratio were significantly improved in broilers added with grit 2 mm compared to the control group (p<0.05, whereas; carcass traits were not significantly altered. These data suggest that grit with size of 2 mm improve growth performance in broiler chickens.

  3. Early Prediction of Student Dropout and Performance in MOOCSs Using Higher Granularity Temporal Information

    Science.gov (United States)

    Ye, Cheng; Biswas, Gautam

    2014-01-01

    Our project is motivated by the early dropout and low completion rate problem in MOOCs. We have extended traditional features for MOOC analysis with richer and higher granularity information to make more accurate predictions of dropout and performance. The results show that finer-grained temporal information increases the predictive power in the…

  4. Effect of the squid viscera hydrolysate on growth performance and digestion in the red sea bream Pagrus major.

    Science.gov (United States)

    Kondo, Fumitaka; Ohta, Takashi; Iwai, Toshiharu; Ido, Atsushi; Miura, Chiemi; Miura, Takeshi

    2017-12-01

    The improvement in feed efficiency is one of the most important subjects in fish culture. The development of feed, in terms of good intake, high growth performance, and high feed efficiency is needed. Squid viscera are one of the candidates for alternative material in improving feed efficiency in fish culture. In the present study, we described the dietary effect of the squid viscera hydrolysate (SVH) on the growth performance of the red sea bream. The addition of SVH to feed caused significant increases in feed intake, fork length, and body weight and produced a marked improvement in feed conversion after 4 weeks of feeding. Furthermore, the results of this feeding revealed that low dietary levels of SVH promote growth performance in the red sea bream. We physiologically analyzed digestion and appetite in fish fed diet containing SVH. SVH promoted the activity of hepatic trypsin and lipase, gene expression of stomach pepsin, hepatic lipase, and pyloric caeca trypsin, thereby improving the nutrient availability in red sea bream. Moreover, the mRNA expression of appetite regulating factor, such as brain NPY and stomach ghrelin was significantly improved by dietary SVH. Our current results indicate that dietary SVH as alternative material produced excellent effects on growth performance, which is dependent on the promoting effect on digestion and appetite in red sea bream.

  5. Trade-off between early emergence and herbivore susceptibility mediates exotic success in an experimental California plant community.

    Science.gov (United States)

    Waterton, Joseph; Cleland, Elsa E

    2016-12-01

    Ecological trade-offs are fundamental to theory in community ecology; critical for understanding species coexistence in diverse plant communities, as well as the evolution of diverse life-history strategies. Invasions by exotic species can provide insights into the importance of trade-offs in community assembly, because the ecological strategies of invading species often differ from those present in the native species pool. Exotic annual species have invaded many Mediterranean-climate areas around the globe, and often germinate and emerge earlier in the growing season than native species. Early-season growth can enable exotic annual species to preempt space and resources, competitively suppressing later-emerging native species; however, early-emerging individuals may also be more apparent to herbivores. This suggests a potential trade-off between seasonal phenology and susceptibility to herbivory. To evaluate this hypothesis, we monitored the emergence and growth of 12 focal species (six each native and exotic) in monoculture and polyculture, while experimentally excluding generalist herbivores both early and later in the growing season. Consistent with past studies, the exotic species emerged earlier than native species. Regardless of species origin, earlier-emerging species achieved greater biomass by the end of the experiment, but were more negatively impacted by herbivory, particularly in the early part of the growing season. This greater impact of early-season herbivory on early-active species led to a reduction in the competitive advantage of exotic species growing in polyculture, and improved the performance of later-emerging natives. Such a trade-off between early growth and susceptibility to herbivores could be an important force in community assembly in seasonal herbaceous-dominated ecosystems. These results also show how herbivore exclusion favors early-active exotic species in this system, with important implications for management in many areas invaded

  6. HOW TO SUSTAIN ECONOMIC PERFORMANCE? ECONOMIC GROWTH AND ITS IMPACT FACTORS

    Directory of Open Access Journals (Sweden)

    OANA SIMONA HUDEA (CARAMAN

    2012-05-01

    Full Text Available This paper intends to render several important factors of impact on economic growth and to describe the particular types of relationships of the latter with each one of its influencing elements. In order to correctly determine such issue, we have resorted to three carefully selected models that have been estimated and compared so as to identify the most adequate and representative regression. For this purpose we have performed an analysis based on cross-section annual data for 105 countries spread all over the world. After having tested and rejected certain exogenous variables initially considered, such as imports or exports, we have finally retained the external debt and foreign direct investments as explanatory items of the dependent variable. The results revealed that both of them positively affect the gross domestic product of the analysed countries, this one being inelastic in relation to the exogenous variables considered. Even if the relationship between the economic growth and the external debt of a country is usually negative, as the money exit out of the country due to the debt service causes non-achieved potential investments, yet, there is an inflexion point up to which the external debt has a positive influence on economic growth by the increase of the investments funds acquired as result of the external credit contracting, this being the case reflected by our study. As for the relationship existing between foreign direct investments and GDP, the economic theory confirms that FDI and economic growth are directly correlated, the former contributing to technical progress, production increase and, finally, to the improvement of the living standard.

  7. Growth facilitators of SME’s in a low-growth region

    DEFF Research Database (Denmark)

    Aagaard, Annabeth; Senderovitz, Martin

    Growth and growth facilitation among SME’s and entrepreneurs have attracted attention from both academics and practitioners for decades. However, the existing literature of growth models tends to oversimplify the different stages, and the inherent determinism in these models does not reflect...... reality, where firms may have individual choices and not pre-destined evolutionary paths. In addition, firm performance is often seen as the outcome or success criteria in the majority of the SME and entrepreneurial management literature, where performance is primarily measured in innovation, financial...... performance, and growth. The objective of this paper and the research project behind has been to compensate for these shortcomings and to achieve application-oriented knowledge of what creates growth in SME’s small and medium enterprises and within a specific low growth region in Denmark. This paper aims...

  8. Growth of Carbon Nanotubes on Clay: Unique Nanostructured Filler for High-Performance Polymer Nanocomposites

    NARCIS (Netherlands)

    Zhang, Wei-De; Phang, In Yee; Liu, Tianxi

    2006-01-01

    High-performance composites are produced using nanostructured clay-carbon nanotube (CNT) hybrids as a reinforcing filler. The intercalation of iron particles between the clay platelets serves as the catalyst for the growth of CNTs, while the platelets are exfoliated by the CNTs, forming the unique

  9. Salivary cytokine levels in early gingival inflammation

    DEFF Research Database (Denmark)

    Belstrøm, Daniel; Damgaard, Christian; Könönen, Eija

    2017-01-01

    Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine levels in early gingival inflammation. The aim of this study was to determine salivary levels of vascular endothelial growth factor (VEGF), interleukin (IL)-8, monocyte chemoattr......Salivary protein levels have been studied in periodontitis. However, there is lack of information on salivary cytokine levels in early gingival inflammation. The aim of this study was to determine salivary levels of vascular endothelial growth factor (VEGF), interleukin (IL)-8, monocyte...

  10. growth performance in clarias gariepinus burchell

    African Journals Online (AJOL)

    Timothy Ademakinwa

    bridge the gap between demand and supply of fish from capture fisheries. High cost ..... Table 4: Growth response and nutrient utilization* of the cultured fish fed different experimental diets ..... Netherlands, ISBN-13: 9789076998411,. Pp: 304.

  11. Differential muscular myosin heavy chain expression of the pectoral and pelvic girdles during early growth in the king penguin (Aptenodytes patagonicus) chick.

    Science.gov (United States)

    Erbrech, Aude; Robin, Jean-Patrice; Guérin, Nathalie; Groscolas, René; Gilbert, Caroline; Martrette, Jean-Marc

    2011-06-01

    Continuous growth, associated with a steady parental food supply, is a general pattern in offspring development. So that young chicks can acquire their locomotor independence, this period is usually marked by a fast maturation of muscles, during which different myosin heavy chain (MyHC) isoforms are expressed. However, parental food provisioning may fluctuate seasonally, and offspring therefore face a challenge to ensure the necessary maturation of their tissues when energy is limited. To address this trade-off we investigated muscle maturation in both the pectoral and pelvic girdles of king penguin chicks. This species has an exceptionally long rearing period (1 year), which is prolonged when parental food provisioning is drastically reduced during the sub-Antarctic winter. Approximately 1 month post hatching, chicks acquire a functional pedestrian locomotion, which uses pelvic muscles, whereas swimming, which uses the pectoral muscles, only occurs 1 year later. We therefore tested the hypothesis that the MyHC content of the leg muscles reaches a mature state before those of the pectoral muscles. We found that leg muscle MyHC composition changed with the progressive acquisition of pedestrian locomotion, whereas pectoral muscle fibres reached their mature MyHC profile as early as hatching. Contrary to our predictions, the acquisition of the adult profile in pectoral muscles could be related to an early maturation of the contractile muscular proteins, presumably associated with early thermoregulatory capacities of chicks, necessary for survival in their cold environment. This differential maturation appears to reconcile both the locomotor and environmental constraints of king penguin chicks during growth.

  12. Group relationships in early and late sessions and improvement in interpersonal problems.

    Science.gov (United States)

    Lo Coco, Gianluca; Gullo, Salvatore; Di Fratello, Carla; Giordano, Cecilia; Kivlighan, Dennis M

    2016-07-01

    Groups are more effective when positive bonds are established and interpersonal conflicts resolved in early sessions and work is accomplished in later sessions. Previous research has provided mixed support for this group development model. We performed a test of this theoretical perspective using group members' (actors) and aggregated group members' (partners) perceptions of positive bonding, positive working, and negative group relationships measured early and late in interpersonal growth groups. Participants were 325 Italian graduate students randomly (within semester) assigned to 1 of 16 interpersonal growth groups. Groups met for 9 weeks with experienced psychologists using Yalom and Leszcz's (2005) interpersonal process model. Outcome was assessed pre- and posttreatment using the Inventory of Interpersonal Problems, and group relationships were measured at Sessions 3 and 6 using the Group Questionnaire. As hypothesized, early measures of positive bonding and late measures of positive working, for both actors and partners, were positively related to improved interpersonal problems. Also as hypothesized, late measures of positive bonding and early measures of positive working, for both actors and partners, were negatively related to improved interpersonal problems. We also found that early actor and partner positive bonding and negative relationships interacted to predict changes in interpersonal problems. The findings are consistent with group development theory and suggest that group therapists focus on group-as-a-whole positive bonding relationships in early group sessions and on group-as-a-whole positive working relationships in later group sessions. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  13. Feed intake, growth performance and digestibility in goats fed whole corn plant silage and Napier grass

    Directory of Open Access Journals (Sweden)

    Khaing, K.T.

    2015-06-01

    Full Text Available Shortage and inconsistent quality of forage in developing countries are the major constraints to the development of ruminant sector. To overcome these problems, feeding of ruminants with conserved forages is an important feeding strategy to ensure the success of ruminant production in the third world countries. The use of whole corn plant as silage has drawn many attention due to high protein efficiency, relatively high digestible energy and total digestible nutrients. Thus, the objective of this study was to determine feed intake, growth performance and nutrients digestibility in goats fed different inclusion level of whole corn plant silage to Napier grass based diets. Fifteen male Boer cross goats around six months old and approximately 18.54 ? 1.83 kg of body weight were used as experimental animals. The goats were assigned into five treatment groups consisted of different proportions of Napier grass (G and whole plant corn silage (CS ?T1:100/0 G/CS; T2:75/25 G/CS; T3:50/50 G/CS; T4:25/75 G/CS and T5:0/100 G/CS. The increase of corn silage to Napier grass proportion demonstrates increase in dry matter intake and growth performance in the goats. The highest nutrient digestibility was observed in T5:0/100 G/CS and T3:50/50 G/CS. It can be concluded that high proportion of corn silage to grass diets had resulted in increases in feed intake and growth performance of goats. Feeding the animals with T5 and T3 resulted in high nutrient utilization compared to other treatments. However, the highest growth performance was observed in animals that were fed with T5 diets.

  14. Postinfancy growth, schooling, and cognitive achievement: Young Lives.

    Science.gov (United States)

    Crookston, Benjamin T; Schott, Whitney; Cueto, Santiago; Dearden, Kirk A; Engle, Patrice; Georgiadis, Andreas; Lundeen, Elizabeth A; Penny, Mary E; Stein, Aryeh D; Behrman, Jere R

    2013-12-01

    Early life growth failure and resulting cognitive deficits are often assumed to be very difficult to reverse after infancy. We used data from Young Lives, which is an observational cohort of 8062 children in Ethiopia, India, Peru, and Vietnam, to determine whether changes in growth after infancy are associated with schooling and cognitive achievement at age 8 y. We represented the growth by height-for-age z score at 1 y [HAZ(1)] and height-for-age z score at 8 y that was not predicted by the HAZ(1). We also characterized growth as recovered (stunted at age 1 y and not at age 8 y), faltered (not stunted at age 1 y and stunted at age 8 y), persistently stunted (stunted at ages 1 and 8 y), or never stunted (not stunted at ages 1 and 8 y). Outcome measures were assessed at age 8 y. The HAZ(1) was inversely associated with overage for grade and positively associated with mathematics achievement, reading comprehension, and receptive vocabulary. Unpredicted growth from 1 to 8 y of age was also inversely associated with overage for grade (OR range across countries: 0.80-0.84) and positively associated with mathematics achievement (effect-size range: 0.05-0.10), reading comprehension (0.02-0.10), and receptive vocabulary (0.04-0.08). Children who recovered in linear growth had better outcomes than did children who were persistently stunted but were not generally different from children who experienced growth faltering. Improvements in child growth after early faltering might have significant benefits on schooling and cognitive achievement. Hence, although early interventions remain critical, interventions to improve the nutrition of preprimary and early primary school-age children also merit consideration.

  15. Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins

    Directory of Open Access Journals (Sweden)

    R.K. Reolon

    2008-08-01

    Full Text Available There have been indications that intrauterine and early extrauterine growth can influence childhood mental and motor function. The objective of the present study was to evaluate the influence of intrauterine growth restriction and early extrauterine head growth on the neurodevelopmental outcome of monozygotic twins. Thirty-six monozygous twin pairs were evaluated at the corrected age of 12 to 42 months. Intrauterine growth restriction was quantified using the fetal growth ratio. The effects of birth weight ratio, head circumference at birth and current head circumference on mental and motor outcomes were estimated using mixed-effect linear regression models. Separate estimates of the between (interpair and within (intrapair effects of each measure on development were thus obtained. Neurodevelopment was assessed with the Bayley Scales of Infant Development, 2nd edition, by a psychologist blind to the exposure. A standardized neurological examination was performed by a neuropediatrician who was unaware of the exposures under investigation. After adjustment, birth weight ratio and head circumference at birth were not associated with motor or mental outcomes. Current head circumference was associated with mental but not with motor outcomes. Only the intrapair twin effect was significant. An increase of 1 cm in current head circumference of one twin compared with the other was associated with 3.2 points higher in Mental Developmental Index (95%CI = 1.06-5.32; P < 0.03. Thus, no effect of intrauterine growth was found on cognition and only postnatal head growth was associated with cognition. This effect was not shared by the co-twin.

  16. Sleep habits, circadian preference, and school performance in early adolescents.

    Science.gov (United States)

    Russo, Paolo M; Biasi, Valeria; Cipolli, Carlo; Mallia, Luca; Caponera, Elisa

    2017-01-01

    This study aimed to cast light on the relationships between sleep habits, perceived sleep problems and school performance in Evening-type (E-type) compared with Morning-type (M-type) early adolescents. Comparison of questionnaire data of E-type and M-type adolescents random-selected from a large sample of eight-grade adolescents who took part in a national survey of competence in mathematics and science. The proportions of sleep problems that were observed to occur more than once per week and the frequency of struggling to fall asleep and/or falling asleep in distinct everyday situations were much higher in E-type than in M-type adolescents. Moreover, E-type adolescents showed more disturbed and poorer sleep during both school and weekend days and reported lower grades in mathematics, science and Italian. E-type adolescents showed a partial recovery of sleep debt during weekend days. This finding suggests that they could improve their school performance if tests and classwork would be scheduled on their most alert school days, namely the post-weekend ones. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. Employment growth in rural regions of the EU; A quantitative analysis for the period 1980-1995

    NARCIS (Netherlands)

    Esposti, R.; Godeschalk, F.E.; Kuhmonen, T.; Post, J.H.; Sotte, F.; Terluin, I.J.

    1999-01-01

    In this report it is examined whether rural regions in the EU with a relatively high (low) employment growth in the 1980s and early 1990s have some common socio-economic characterics, which can contribute to the explanation of their employment performance. We have grouped the socio-economic

  18. Experimental study of heterogeneous organic chemistry induced by far ultraviolet light: Implications for growth of organic aerosols by CH3 addition in the atmospheres of Titan and early Earth

    Science.gov (United States)

    Hong, Peng; Sekine, Yasuhito; Sasamori, Tsutoni; Sugita, Seiji

    2018-06-01

    Formation of organic aerosols driven by photochemical reactions has been observed and suggested in CH4-containing atmospheres, including Titan and early Earth. However, the detailed production and growth mechanisms of organic aerosols driven by solar far ultraviolet (FUV) light remain poorly constrained. We conducted laboratory experiments simulating photochemical reactions in a CH4sbnd CO2 atmosphere driven by the FUV radiations dominated by the Lyman-α line. In the experiments, we analyzed time variations in thickness and infrared spectra of solid organic film formed on an optical window in a reaction cell. Gas species formed by FUV irradiation were also analyzed and compared with photochemical model calculations. Our experimental results show that the growth rate of the organic film decreases as the CH4/CO2 ratio of reactant gas mixture decreases, and that the decrease becomes very steep for CH4/CO2 organic film but that the addition reaction of CH3 radicals onto the organic film with the reaction probability around 10-2 can explain the growth rate. At CH4/CO2 organic film. Our results suggest that organic aerosols would grow through CH3 addition onto the surface during the precipitation of aerosol particles in the middle atmosphere of Titan and early Earth. On Titan, effective CH3 addition would reduce C2H6 production in the atmosphere. On early Earth, growth of aerosol particles would be less efficient than those on Titan, possibly resulting in small-sized monomers and influencing UV shielding.

  19. Early detection of fungal growth in bakery products by use of an electronic nose based on mass spectrometry.

    Science.gov (United States)

    Vinaixa, Maria; Marín, Sonia; Brezmes, Jesús; Llobet, Eduard; Vilanova, Xavier; Correig, Xavier; Ramos, Antonio; Sanchis, Vicent

    2004-10-06

    This paper presents the design, optimization, and evaluation of a mass spectrometry-based electronic nose (MS e-nose) for early detection of unwanted fungal growth in bakery products. Seven fungal species (Aspergillus flavus, Aspergillus niger, Eurotium amstelodami, Eurotium herbariorum, Eurotium rubrum, Eurotium repens, and Penicillium corylophillum) were isolated from bakery products and used for the study. Two sampling headspace techniques were tested: static headspace (SH) and solid-phase microextraction (SPME). Cross-validated models based on principal component analysis (PCA), coupled to discriminant function analysis (DFA) and fuzzy ARTMAP, were used as data treatment. When attempting to discriminate between inoculated and blank control vials or between genera or species of in vitro growing cultures, sampling based on SPME showed better results than those based on static headspace. The SPME-MS-based e-nose was able to predict fungal growth with 88% success after 24 h of inoculation and 98% success after 48 h when changes were monitored in the headspace of fungal cultures growing on bakery product analogues. Prediction of the right fungal genus reached 78% and 88% after 24 and 96 h, respectively.

  20. Effects of different rearing systems on growth performance, carcass traits, meat quality and serum biochemical parameters of Chaohu ducks.

    Science.gov (United States)

    Zhang, Cheng; Ah Kan Razafindrabe, Richard-Hermann; Chen, Kaikai; Zhao, Xiaohui; Yang, Lei; Wang, Li; Chen, Xingyong; Jin, Sihua; Geng, Zhaoyu

    2018-04-01

    This study was conducted using a total of 360 22-day-old Chaohu ducks to evaluate the effect of rearing system on growth performance, carcass traits, meat quality and serum parameters of male and female Chaohu ducks. The birds were divided and raised in separate pens according to sex and rearing system, with three replicate pens of 30 male or 30 female ducks per pen for each rearing system. The rearing systems consisted of a floor rearing system (FRS) and a net rearing system (NRS). Results showed that ducks raised in NRS had better growth performance, whereas, ducks raised in FRS exhibited better carcass traits and meat color, and lower intramuscular fat. For the serum parameters, NRS significantly decreased high-density lipoprotein cholesterol content, and enhanced total protein and triacylglycerol contents. Male ducks had lower abdominal fat percentage, and higher growth performance and shear force, but there were no other significant differences between sexes. No rearing system × sex interaction was observed in the present study, revealing that rearing system had the same effect on both sexes. In conclusion, NRS was beneficial to the growth performance of Chaohu ducks, whereas this system had some negative effects on carcass traits, meat quality and serum profiles. © 2018 Japanese Society of Animal Science.