WorldWideScience

Sample records for ea sti-195 wes

  1. Wes Jackson. In nature's way.

    Science.gov (United States)

    1992-09-01

    The opinions and a biographical sketch of Wes Jackson, the founder of the Land Institute, are presented. The land Institute near Salina, Kansas is a nonprofit organization devoted to sustainable agriculture. Opinions are provided on the relationship of the Land Institute to sustainable agriculture, the definition of sustainability, the feasibility of replication of his work, his ideas about the destruction wreaked by the plow vs. the sword, technology and population growth, the future farmer, and the speed with which modern science has destroyed the ozone layer. Sustainable agriculture is using the prairie to provide answers to how agriculture can work with nature; the approach will take longer but will sustain both agriculture and people for another 10,000 years. The system runs on sunlight and recycles all materials and is based on the principles of ecosystems, which have been around for hundreds of years. Agricultural technology is based on a fossil fuel intensive infrastructure and is "parachuted into Third World countries." "Corn - the gift of the gods has been the killer of this continent." 50% of the topsoil has been lost, and soil is more important than oil. Advances in biotechnology are seen as the "human cleverness" approach; the preference is for an ecological approach first. Biotechnology tells how to "spin wheels faster," but it also generates more waste. The future farmer is more like the 19th century British naturalist. A projection is that 1st the oil is used up, then the natural gas, and when nuclear power is embraced, Murphy's Law must be repealed. It is important to understand the "we can'ts". Realization of limits will direct energy to the sun's potential and recycling and the flow of energy. Descartes' notion of correctable ignorance must be repudiated. Our knowledge-based world has led to acid rain, global warming, the ozone hole, and Chernobyl. It took just 25 years for chlorofluorocarbons to destroy the ozone layer. A philosophical shift in

  2. DIE VRYWILLIGERSMAGTE VAN GRIEKWALAND-WES

    African Journals Online (AJOL)

    teen gekant was, is dit op 15 Oktober 1880 by die Kaapkolonie ingelyf.9. Gedurende sy kortstondige bestaan van minder as 'n dekade lank het die kroonkolonie Griekwa- land-Wes met talle finansiele, ekonomiese, so- siale en ander probleme te doen gehad. Een van die ernstige probleme was die bedreiging wat.

  3. ENGLISH / PIDGIN-ENGLISH (WES-KOS), PRELIMINARY GLOSSARY.

    Science.gov (United States)

    SCHNEIDER, GILBERT D.

    THIS PRELIMINARY GLOSSARY OF ENGLISH / PIDGIN-ENGLISH (WES-KOS) HAS BEEN USED IN PEACE CORPS TRAINING PROGRAMS. WES-KOS (IN USE SINCE THE 18TH CENTURY) IS USED THROUGHOUT WEST AFRICA, HOWEVER THE GLOSSES IN THIS TEXT ARE THE COMMON CULTURAL-LINGUISTIC EQUIVALENTS USED IN WEST CAMEROON AND EASTERN NIGERIA. A BRIEF STATEMENT IS GIVEN IN THE…

  4. Buffels (Wes), Elsies, Sir Lowry's pass, Steenbras and Buffels (Oos)

    CSIR Research Space (South Africa)

    Heinecken, TJE

    1982-06-01

    Full Text Available This report is a synthesis of all available information on five of the smaller rivers discharging in to False bay combined as a single volume. The rivers dealt with are the Buffels (Wes), Elsies, Sir Lowry' Pass, Steenbras and Buffels (Oos). False...

  5. A 'new' Cromer-related high frequency antigen probably antithetical to WES.

    Science.gov (United States)

    Daniels, G L; Green, C A; Darr, F W; Anderson, H; Sistonen, P

    1987-01-01

    An antibody to a high frequency antigen, made in a WES+ Black antenatal patient (Wash.), failed to react with the red cells of a presumed WES+ homozygote and is, therefore, probably antithetical to anti-WES. Like anti-WES, it reacted with papain, ficin, trypsin or neuraminidase treated cells but not with alpha-chymotrypsin or pronase treated cells and was specifically inhibited by concentrated serum. It also reacted more strongly in titration with WES- cells than with WES+ cells. The antibody is Cromer-related as it failed to react with Inab phenotype (IFC-) cells and reacted only weakly with Dr(a-) cells. Wash. cells and those of the other possible WES+ homozygote are Cr(a+) Tc(a+b-c-) Dr(a+) IFC+ but reacted only very weakly with anti-Esa.

  6. NOAA Weather Radio - EAS Description

    Science.gov (United States)

    Non-Zero All Hazards Logo Emergency Alert Description Event Codes Fact Sheet FAQ Organization Search Search For Go NWS All NOAA Emergency Alert System (EAS) List of EAS Event Codes NWS EAS fact sheet What Management Agency (FEMA) and the NWS, implements the EAS at the federal level. The EAS is the nation's public

  7. Investigation of EAS cores

    Directory of Open Access Journals (Sweden)

    Shaulov S.B.

    2017-01-01

    Full Text Available The development of nuclear-electromagnetic cascade models in air in the late forties have shown informational content of the study of cores of extensive air showers (EAS. These investigations were the main goal in different experiments which were carried out over many years by a variety of methods. Outcomes of such investigations obtained in the HADRON experiment using an X-ray emulsion chamber (XREC as a core detector are considered. The Ne spectrum of EAS associated with γ-ray families, spectra of γ-rays (hadrons in EAS cores and the Ne dependence of the muon number, ⟨Nμ⟩, in EAS with γ-ray families are obtained for the first time at energies of 1015–1017 eV with this method. A number of new effects were observed, namely, an abnormal scaling violation in hadron spectra which are fundamentally different from model predictions, an excess of muon number in EAS associated with γ-ray families, and the penetrating component in EAS cores. It is supposed that the abnormal behavior of γ-ray spectra and Ne dependence of the muon number are explained by the emergence of a penetrating component in the 1st PCR spectrum ‘knee’ range. Nuclear and astrophysical explanations of the origin of the penetrating component are discussed. The necessity of considering the contribution of a single close cosmic-ray source to explain the PCR spectrum in the knee range is noted.

  8. Die Welt als Puppenhaus. Die verzauberten Filme des Wes Anderson als Retrospektive im Kino Xenix

    OpenAIRE

    Binotto, Johannes

    2012-01-01

    Nur gerade sieben Filme hat der Regisseur und Autor Wes Anderson bisher gemacht, damit aber ein einzigartiges Œuvre geschaffen. Das Xenix zeigt diese melancholischen und verspielten Kunstwerke, zusammen mit Filmen, die als Inspiration dienten.

  9. EAS Telecommunications Certification Bodies (TCB)

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). A Telecommunication Certification Body (TCB) is an accredited product certification body with the authority to issue Grants of...

  10. EAS Equipment Authorization Grantee Registrations

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). Radio Frequency (RF) devices are required to be properly authorized under 47 CFR Part 2 prior to being marketed or imported...

  11. WES Evaluation of the Three-Year Bachelor's Degree from India. Updated

    Science.gov (United States)

    World Education Services, 2014

    2014-01-01

    Based on its research and review of fundamental changes in quality assurance in higher education in India, in 2006 World Education Services (WES) revised its assessment of selected the three-year Bachelor's degree awarded by Indian universities. This policy takes into account specific criteria regarding institutional standing and student…

  12. Clinical Application of the PES/WES Index on Natural Teeth: Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Alessandro Lanza

    2017-01-01

    Full Text Available The use of reliable indices to evaluate the aesthetic outcomes in the aesthetic area is an important and objective clinical aid to monitor the results over time. According to the literature various indices were proposed to evaluate aesthetic outcomes of implant-prosthetic rehabilitation of the anterior area like Peri-Implant and Crown Index [PICI], Implant Crown Aesthetic Index [ICAI], Pink Esthetic Score/White Esthetic Score [PES/WES], and Pink Esthetic Score [PES] but none of them was related to prosthetic rehabilitation on natural teeth. The aim of this study is to verify the validity of PES/WES index for natural tooth-prosthetic rehabilitation of the anterior area. As secondary objective, we proposed to evaluate the long-term predictability of this clinical application, one of which is presented below, following the analysis of the most currently accepted literature.

  13. Clinical Application of the PES/WES Index on Natural Teeth: Case Report and Literature Review

    OpenAIRE

    Lanza, Alessandro; Di Francesco, Fabrizio; De Marco, Gennaro; Femiano, Felice; Itro, Angelo

    2017-01-01

    The use of reliable indices to evaluate the aesthetic outcomes in the aesthetic area is an important and objective clinical aid to monitor the results over time. According to the literature various indices were proposed to evaluate aesthetic outcomes of implant-prosthetic rehabilitation of the anterior area like Peri-Implant and Crown Index [PICI], Implant Crown Aesthetic Index [ICAI], Pink Esthetic Score/White Esthetic Score [PES/WES], and Pink Esthetic Score [PES] but none of them was relat...

  14. Comparison of absolute intensity between EAS with gamma families and general EAS at Mount Norikura

    International Nuclear Information System (INIS)

    Mitsumune, T.; Nakatsuka, T.; Nishikawa, K.

    1985-01-01

    Gamma families with total energy greater than 10 TeV, found in the EX chamber which was cooperated with the EAS array, were combined with EAS triggered by big bursts. The absolute intensity of the size spectrum of these combined EAS was compared with that of general EAS obtained by AS trigger. The EAS with sizes greater than 2x1 million were always accompanied by gamma families with sigma E sub gamma H 10 TeV, n sub gamma, H 2 and Emin=3 TeV, although the rate of EAS accompaning such gamma families decreases rapidly as their sizes decrease

  15. 47 CFR 11.31 - EAS protocol.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false EAS protocol. 11.31 Section 11.31... characters. FM or TV call signs must use a slash ASCII character number 47 (/) in lieu of a dash. (c) The EAS... the State EAS Mapbook. FIPS# State: AL 01 AK 02 AZ 04 AR 05 CA 06 CO 08 CT 09 DE 10 DC 11 FL 12 GA 13...

  16. OneVA EA Vision and Strategy

    Data.gov (United States)

    Department of Veterans Affairs — The outcomes/goals supported by effective use of an EA are: Improved Service Delivery, Functional Integration, Resource Optimization and Authoritative Reference. VA...

  17. Aproximació a l'univers fílmic de Wes Anderson: existeix una marca autoral?

    OpenAIRE

    Cadena Hernández, Adrià

    2016-01-01

    Al llarg del anys Wes Anderson s'ha postulat com un dels directors contemporanis més importants i influents. Aquest estudi revisa la totalitat de la seva filmografia, centrant-se en la seva última pel·lícula "The Grand Budapest Hotel". L'anàlisi pretén verificar si Wes Anderson pot ser considerat o no autor de les seves pel·lícules en base a les pautes estipulades per la política d'autors provinent de la Nouvelle Vague. A lo largo de los últimos años Wes Anderson se ha postulado como uno d...

  18. Exploratory factorial analysis of the working enviroment scale (WES among employees of a public psychiatric hospital in Bucaramanga, Colombia

    Directory of Open Access Journals (Sweden)

    Lucía Quintero Isaza

    2007-01-01

    Full Text Available Background. Job satisfaction is an important factor to guarantee work productivity. There are various scales to measure job satisfaction. Out of these scales, the recently validated Working Environment Scale-10 (WES-10 is the most brief. However, up to date the factor structure of the WES-10 has not been explored among any Colombian working populations. Objective. To determine the factor structure of the WES-10 among employees of a public psychiatric hospital in Bucaramanga, Colombia. Materials and methods. It was designed a validation study without a gold standard. Two-hundred seventeen workers participated, the mean age was 37.7 years (SD±9.8; 75.4% were women; 49.5% were narried; 37.0% were technical or vocacional degree; 58.7% lived in middle class neigbourhood; 51.7% were assistancial functions; and have been working in the hospital the mean of 13.0 year (SD± 8.8. The WES-10 is a 10-item device with five options of ordinal answer. It was done an exploratory factor analysis using the principal component method. Factors with eigenvalue over 1.0 were retrained. Results. The WES-10 showed internal consistency of 0.78 and bidimensional structure accounted for 48.8% of the variance. Factor one (working adjustment presented an eigenvalue of 3.49; and factor two (self-realization, 1.39. Conclusions. The WES-10 presents an acceptable internal consistency and may be used for research purposes. Its bidimentional structure explores approximately the proposed construct.

  19. O design de produção nos filmes de Wes Anderson

    OpenAIRE

    Cunha, Humberto Thimoteo

    2009-01-01

    Esse projeto pesquisa a relação entre design e cinema, seguindo a linha do design de produção, o estudo da escolha de locações, a disposição de cenários, móveis e objetos. Posteriormente faz uma análise dos filmes do diretor Wes Anderson, buscando a importância dessa atividade no processo de produção dos filmes, analisando elementos de design de produção como objetos cenários e móveis, também elementos de figurino e elementos de pós-produção. A ánalise buscará mostrar que a importância do...

  20. Impact of conservatism on the Ea process

    International Nuclear Information System (INIS)

    Pelletier, C.A.

    1985-01-01

    Although starting out with an admitted negative view of the impact of conservatism on the Ea process, the opposite conclusion is reached. Overall, the impact of the authors conservatism has been positive

  1. EAS 2.948 Listed Test Firms

    Data.gov (United States)

    Federal Communications Commission — EAS (Equipment Authorization System). The following firms have submitted the information required by Section 2.948 of the FCC Rules for measuring devices subject to...

  2. Web-based Weather Expert System (WES) for Space Shuttle Launch

    Science.gov (United States)

    Bardina, Jorge E.; Rajkumar, T.

    2003-01-01

    The Web-based Weather Expert System (WES) is a critical module of the Virtual Test Bed development to support 'go/no go' decisions for Space Shuttle operations in the Intelligent Launch and Range Operations program of NASA. The weather rules characterize certain aspects of the environment related to the launching or landing site, the time of the day or night, the pad or runway conditions, the mission durations, the runway equipment and landing type. Expert system rules are derived from weather contingency rules, which were developed over years by NASA. Backward chaining, a goal-directed inference method is adopted, because a particular consequence or goal clause is evaluated first, and then chained backward through the rules. Once a rule is satisfied or true, then that particular rule is fired and the decision is expressed. The expert system is continuously verifying the rules against the past one-hour weather conditions and the decisions are made. The normal procedure of operations requires a formal pre-launch weather briefing held on Launch minus 1 day, which is a specific weather briefing for all areas of Space Shuttle launch operations. In this paper, the Web-based Weather Expert System of the Intelligent Launch and range Operations program is presented.

  3. Novel Genetic Variants of Sporadic Atrial Septal Defect (ASD) in a Chinese Population Identified by Whole-Exome Sequencing (WES).

    Science.gov (United States)

    Liu, Yong; Cao, Yu; Li, Yaxiong; Lei, Dongyun; Li, Lin; Hou, Zong Liu; Han, Shen; Meng, Mingyao; Shi, Jianlin; Zhang, Yayong; Wang, Yi; Niu, Zhaoyi; Xie, Yanhua; Xiao, Benshan; Wang, Yuanfei; Li, Xiao; Yang, Lirong; Wang, Wenju; Jiang, Lihong

    2018-03-05

    BACKGROUND Recently, mutations in several genes have been described to be associated with sporadic ASD, but some genetic variants remain to be identified. The aim of this study was to use whole-exome sequencing (WES) combined with bioinformatics analysis to identify novel genetic variants in cases of sporadic congenital ASD, followed by validation by Sanger sequencing. MATERIAL AND METHODS Five Han patients with secundum ASD were recruited, and their tissue samples were analyzed by WES, followed by verification by Sanger sequencing of tissue and blood samples. Further evaluation using blood samples included 452 additional patients with sporadic secundum ASD (212 male and 240 female patients) and 519 healthy subjects (252 male and 267 female subjects) for further verification by a multiplexed MassARRAY system. Bioinformatic analyses were performed to identify novel genetic variants associated with sporadic ASD. RESULTS From five patients with sporadic ASD, a total of 181,762 genomic variants in 33 exon loci, validated by Sanger sequencing, were selected and underwent MassARRAY analysis in 452 patients with ASD and 519 healthy subjects. Three loci with high mutation frequencies, the 138665410 FOXL2 gene variant, the 23862952 MYH6 gene variant, and the 71098693 HYDIN gene variant were found to be significantly associated with sporadic ASD (PASD (PASD, and supported the use of WES and bioinformatics analysis to identify disease-associated mutations.

  4. EA Training 2.0 Newsletter #3 - EA Active, Problem Based Learning Methodology

    DEFF Research Database (Denmark)

    Buus, Lillian; Ryberg, Thomas; Sroga, Magdalena

    2010-01-01

    The main products of the project are innovative, active problem-based learning methodology for EA education and training, EA courses for university students and private and public sector employees, and an Enterprise Architecture competence ontology including a complete specification of skills...

  5. EAS selection in the EMMA underground array

    DEFF Research Database (Denmark)

    Sarkamo, J.; Bezrukov, L.; Enqvist, T.

    2013-01-01

    The first measurements of the Experiment with MultiMuon Array (EMMA) have been analyzed for the selection of the Extensive Air Showers (EAS). Test data were recorded with an underground muon tracking station and a satellite station separated laterally by 10 metres. Events with tracks distributed...

  6. 47 CFR 11.33 - EAS Decoder.

    Science.gov (United States)

    2010-10-01

    ..., satellite, public switched telephone network, or any other source that uses the EAS protocol. (2) Valid..., analog radio and television broadcast stations, analog cable systems and wireless cable systems may... program data must be retained even with power removed. (7) Outputs. Decoders shall have the following...

  7. 47 CFR 11.32 - EAS Encoder.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EMERGENCY ALERT SYSTEM (EAS) Equipment Requirements § 11... operation. (vi) Indicator Display. The encoder shall be provided with a visual and/or aural indicator which... to +50 degrees C and a range of relative humidity of up to 95%. (c) Primary Supply Voltage Variation...

  8. A clinically driven variant prioritization framework outperforms purely computational approaches for the diagnostic analysis of singleton WES data.

    Science.gov (United States)

    Stark, Zornitza; Dashnow, Harriet; Lunke, Sebastian; Tan, Tiong Y; Yeung, Alison; Sadedin, Simon; Thorne, Natalie; Macciocca, Ivan; Gaff, Clara; Oshlack, Alicia; White, Susan M; James, Paul A

    2017-11-01

    Rapid identification of clinically significant variants is key to the successful application of next generation sequencing technologies in clinical practice. The Melbourne Genomics Health Alliance (MGHA) variant prioritization framework employs a gene prioritization index based on clinician-generated a priori gene lists, and a variant prioritization index (VPI) based on rarity, conservation and protein effect. We used data from 80 patients who underwent singleton whole exome sequencing (WES) to test the ability of the framework to rank causative variants highly, and compared it against the performance of other gene and variant prioritization tools. Causative variants were identified in 59 of the patients. Using the MGHA prioritization framework the average rank of the causative variant was 2.24, with 76% ranked as the top priority variant, and 90% ranked within the top five. Using clinician-generated gene lists resulted in ranking causative variants an average of 8.2 positions higher than prioritization based on variant properties alone. This clinically driven prioritization approach significantly outperformed purely computational tools, placing a greater proportion of causative variants top or in the top 5 (permutation P-value=0.001). Clinicians included 40 of the 49 WES diagnoses in their a priori list of differential diagnoses (81%). The lists generated by PhenoTips and Phenomizer contained 14 (29%) and 18 (37%) of these diagnoses respectively. These results highlight the benefits of clinically led variant prioritization in increasing the efficiency of singleton WES data analysis and have important implications for developing models for the funding and delivery of genomic services.

  9. Wes Andersons färgstarka värld : En studie av färg i film

    OpenAIRE

    Hallenquist, Peter

    2009-01-01

      Abstract The focus of this essay is the american director Wes Anderson and the use of colour in his films. I also put some focus on colour as a neglected element in film studies, and what has caused this neglect. In my own research, I have analysed three of Anderson's films: Bottle Rocket (1996), The Royal Tenenbaums (2001) and The Darjeeling Limited (2007). To get a broad sense of a films use of colour, I have investigated the colour scheme, the colours of the costumes, as well as colour p...

  10. CASA-MIA: A ''precision'' EAS detector

    International Nuclear Information System (INIS)

    Borione, A.; Cronin, J.W.; Covault, C.E.; Fick, B.E.; Gibbs, K.G.; Krimm, H.A.; McKay, T.A.; Mueller, D.; Newport, B.J.; Ong, R.A.; Rosenberg, L.J.; Catanese, M.; Green, K.D.; Matthews, J.; Nitz, D.F.; Sinclair, D.; van der Velde, J.C.; Kieda, D.

    1993-01-01

    The CASA-MIA detector was constructed to search for sources of UHE neutral radiation. As such it has established limits well below those of previously reported observations and of most contemporaneous detectors. In addition to its primary mission, however, CASA-MIA measures the lateral distribution of both electrons and muons in EAS throughout a range of energies and with a degree of sampling not previously available

  11. Performance comparisons between PCA-EA-LBG and PCA-LBG-EA approaches in VQ codebook generation for image compression

    Science.gov (United States)

    Tsai, Jinn-Tsong; Chou, Ping-Yi; Chou, Jyh-Horng

    2015-11-01

    The aim of this study is to generate vector quantisation (VQ) codebooks by integrating principle component analysis (PCA) algorithm, Linde-Buzo-Gray (LBG) algorithm, and evolutionary algorithms (EAs). The EAs include genetic algorithm (GA), particle swarm optimisation (PSO), honey bee mating optimisation (HBMO), and firefly algorithm (FF). The study is to provide performance comparisons between PCA-EA-LBG and PCA-LBG-EA approaches. The PCA-EA-LBG approaches contain PCA-GA-LBG, PCA-PSO-LBG, PCA-HBMO-LBG, and PCA-FF-LBG, while the PCA-LBG-EA approaches contain PCA-LBG, PCA-LBG-GA, PCA-LBG-PSO, PCA-LBG-HBMO, and PCA-LBG-FF. All training vectors of test images are grouped according to PCA. The PCA-EA-LBG used the vectors grouped by PCA as initial individuals, and the best solution gained by the EAs was given for LBG to discover a codebook. The PCA-LBG approach is to use the PCA to select vectors as initial individuals for LBG to find a codebook. The PCA-LBG-EA used the final result of PCA-LBG as an initial individual for EAs to find a codebook. The search schemes in PCA-EA-LBG first used global search and then applied local search skill, while in PCA-LBG-EA first used local search and then employed global search skill. The results verify that the PCA-EA-LBG indeed gain superior results compared to the PCA-LBG-EA, because the PCA-EA-LBG explores a global area to find a solution, and then exploits a better one from the local area of the solution. Furthermore the proposed PCA-EA-LBG approaches in designing VQ codebooks outperform existing approaches shown in the literature.

  12. A vueltas con la alfabetización visual: lenguaje y significado en las películas de Wes Anderson

    OpenAIRE

    Ferreras Rodríguez, José Gabriel; Leite, Lucimeire Virgilio

    2008-01-01

    El presente artículo tiene por objetivo discutir algunos elementos del concepto de la alfabetización visual, aplicando, luego, las herramientas de análisis de imágenes a las películas de Wes Anderson, como ejemplos del manejo intencional de las imágenes para transmitir determinados significados. The present article aims to discuss, firstly, some elements encompassed in the definition of visual literary and, secondly, to apply some image analysis tools to Wes Anderson’s movies, as examples ...

  13. A vueltas con la alfabetización visual: lenguaje y significado en las películas de Wes Anderson

    OpenAIRE

    José Gabriel Ferreras Rodríguez; Lucimeire Vergilio Leite

    2008-01-01

    El presente artículo tiene por objetivo discutir algunos elementos del concepto de la alfabetización visual, aplicando, luego, las herramientas de análisis de imágenes a las películas de Wes Anderson, como ejemplos del manejo intencional de las imágenes para transmitir determinados significados. The present article aims to discuss, firstly, some elements encompassed in the definition of visual literary and, secondly, to apply some image analysis tools to Wes Anderson’s movies, as examples of...

  14. A vueltas con la alfabetización visual: lenguaje y significado en las películas de Wes Anderson

    Directory of Open Access Journals (Sweden)

    José Gabriel Ferreras Rodríguez

    2008-01-01

    Full Text Available El presente artículo tiene por objetivo discutir algunos elementos del concepto de la alfabetización visual, aplicando, luego, las herramientas de análisis de imágenes a las películas de Wes Anderson, como ejemplos del manejo intencional de las imágenes para transmitir determinados significados. The present article aims to discuss, firstly, some elements encompassed in the definition of visual literary and, secondly, to apply some image analysis tools to Wes Anderson’s movies, as examples of intentional pictorial organization so as to convey specific meanings.

  15. Environmental Agents Service (EAS) Registry System of Records

    Data.gov (United States)

    Department of Veterans Affairs — The Environmental Agent Service (EAS) Registries is the information system encompassing the Ionizing Radiation Registry (IRR), the Agent Orange Registry (AOR), and...

  16. Reconceptualizing public participation in environmental assessment as EA civics

    International Nuclear Information System (INIS)

    Sinclair, A. John; Diduck, Alan P.

    2017-01-01

    Notwithstanding the considerable attention placed on creating meaningful opportunities for public participation in environmental assessment (EA), many participants and those who have reviewed participation processes often find practice sorely wanting. This reality stands in stark juxtaposition to future environmental governance needs, which will require increased openness, deliberation and transdisciplinary knowledge in order to deal with environmental change that is ever more uncertain, complex and conflictual. In this paper, our purpose was to consider how to meet those needs through reconceptualizing public participation as EA civics, founded on an active citizen base, deliberative in nature and orientated toward learning. We do this through developing a new conceptual model of next generation participation processes that is relevant at multiple spatial scales and institutional levels, is applicable to the entire assessment cycle and spans temporal scales through feedback loops. Our EA civics model builds on the “civics approach” to environmental governance and “action civics” by extending their core ideas to participation in EA. We did this by conducting an integrative literature review (including numerous papers we have contributed over the years) and reflecting on our own experiences as EA participants. We apply current thinking on public participation design to our EA civics conceptualization and highlight important design features that have received scant attention. We conclude that EA civics holds promise for fairer and more robust participation processes if all aspects of the model are considered and the actions related to each are implemented. - Highlights: • Consideration of the ‘civics approach’ and ‘action civics’ in an EA context • Conceptualization of public participation as EA civics • Reflection on the EA civics as a model of participation suitable for next generation assessment

  17. Reconceptualizing public participation in environmental assessment as EA civics

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, A. John, E-mail: jsincla@umanitoba.ca [Natural Resources Institute, University of Manitoba, Winnipeg, MB R3T 2N2 (Canada); Diduck, Alan P., E-mail: a.diduck@uwinnipeg.ca [Department of Environmental Studies and Sciences, University of Winnipeg, 515 Portage Avenue, Winnipeg R3B 2E9 (Canada)

    2017-01-15

    Notwithstanding the considerable attention placed on creating meaningful opportunities for public participation in environmental assessment (EA), many participants and those who have reviewed participation processes often find practice sorely wanting. This reality stands in stark juxtaposition to future environmental governance needs, which will require increased openness, deliberation and transdisciplinary knowledge in order to deal with environmental change that is ever more uncertain, complex and conflictual. In this paper, our purpose was to consider how to meet those needs through reconceptualizing public participation as EA civics, founded on an active citizen base, deliberative in nature and orientated toward learning. We do this through developing a new conceptual model of next generation participation processes that is relevant at multiple spatial scales and institutional levels, is applicable to the entire assessment cycle and spans temporal scales through feedback loops. Our EA civics model builds on the “civics approach” to environmental governance and “action civics” by extending their core ideas to participation in EA. We did this by conducting an integrative literature review (including numerous papers we have contributed over the years) and reflecting on our own experiences as EA participants. We apply current thinking on public participation design to our EA civics conceptualization and highlight important design features that have received scant attention. We conclude that EA civics holds promise for fairer and more robust participation processes if all aspects of the model are considered and the actions related to each are implemented. - Highlights: • Consideration of the ‘civics approach’ and ‘action civics’ in an EA context • Conceptualization of public participation as EA civics • Reflection on the EA civics as a model of participation suitable for next generation assessment.

  18. Use of capillary Western immunoassay (Wes) for quantification of dystrophin levels in skeletal muscle of healthy controls and individuals with Becker and Duchenne muscular dystrophy.

    Science.gov (United States)

    Beekman, Chantal; Janson, Anneke A; Baghat, Aabed; van Deutekom, Judith C; Datson, Nicole A

    2018-01-01

    Duchenne muscular dystrophy (DMD) is a neuromuscular disease characterized by progressive weakness of the skeletal and cardiac muscles. This X-linked disorder is caused by open reading frame disrupting mutations in the DMD gene, resulting in strong reduction or complete absence of dystrophin protein. In order to use dystrophin as a supportive or even surrogate biomarker in clinical studies on investigational drugs aiming at correcting the primary cause of the disease, the ability to reliably quantify dystrophin expression in muscle biopsies of DMD patients pre- and post-treatment is essential. Here we demonstrate the application of the ProteinSimple capillary immunoassay (Wes) method, a gel- and blot-free method requiring less sample, antibody and time to run than conventional Western blot assay. We optimized dystrophin quantification by Wes using 2 different antibodies and found it to be highly sensitive, reproducible and quantitative over a large dynamic range. Using a healthy control muscle sample as a reference and α-actinin as a protein loading/muscle content control, a panel of skeletal muscle samples consisting of 31 healthy controls, 25 Becker Muscle dystrophy (BMD) and 17 DMD samples was subjected to Wes analysis. In healthy controls dystrophin levels varied 3 to 5-fold between the highest and lowest muscle samples, with the reference sample representing the average of all 31 samples. In BMD muscle samples dystrophin levels ranged from 10% to 90%, with an average of 33% of the healthy muscle average, while for the DMD samples the average dystrophin level was 1.3%, ranging from 0.7% to 7% of the healthy muscle average. In conclusion, Wes is a suitable, efficient and reliable method for quantification of dystrophin expression as a biomarker in DMD clinical drug development.

  19. Enrichment of Microbial Cultures for Hydrolysis of EA2192

    National Research Council Canada - National Science Library

    Rastogi, Vipin

    1998-01-01

    .... The enrichment was initiated using consortium adapted to biodegrade hydrolyzed vx (courtesy Dr. DeFrank). Based on NMR analysis, the concentration of EA2192 reduced from 120 ppm to 50 ppm in 48 hr of growth...

  20. EAS vahendas mullu Harjumaale 47 miljonit krooni toetusi / Allar Korjas

    Index Scriptorium Estoniae

    Korjas, Allar

    2005-01-01

    Möödunud aastal jõudis EAS- i vahendusel alustavate ja tegutsevate ettevõtete ning regionaalse arengu toetamiseks Harjumaale 47,1 miljonit krooni. Tabel. Vt. samas: Aare Ets. Regionaalne koostöö Harjumaal on oluline

  1. Chemical and laboratory analyses oceanographic data collected aboard the Wes Bordelon in the Gulf of Mexico from 2010-08-18 to 2010-08-22 in response to the Deepwater Horizon Oil Spill event (NODC Accession 0074863)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and laboratory analyses oceanographic data were collected aboard the Wes Bordelon in the Gulf of Mexico from 2010-08-18 to 2010-08-22 in response to the...

  2. Noise properties and cascadability of SOA-EA regenerators

    DEFF Research Database (Denmark)

    Öhman, Filip; Bischoff, Svend; Tromborg, Bjarne

    2002-01-01

    We suggest and analyse a new device containing concatenated pairs of semiconductor optical amplifiers (SOAs) and electroabsorption modulators (EAs). The device has regenerative properties and improves the cascadability of optical fibre links.......We suggest and analyse a new device containing concatenated pairs of semiconductor optical amplifiers (SOAs) and electroabsorption modulators (EAs). The device has regenerative properties and improves the cascadability of optical fibre links....

  3. The Tunka-133 EAS Cherenkov light array: Status of 2011

    International Nuclear Information System (INIS)

    Berezhnev, S.F.; Besson, D.; Budnev, N.M.; Chiavassa, A.; Chvalaev, O.A.; Gress, O.A.; Dyachok, A.N.; Epimakhov, S.N.; Haungs, A.; Karpov, N.I.; Kalmykov, N.N.; Konstantinov, E.N.; Korobchenko, A.V.; Korosteleva, E.E.; Kozhin, V.A.; Kuzmichev, L.A.; Lubsandorzhiev, B.K.; Lubsandorzhiev, N.B.; Mirgazov, R.R.; Panasyuk, M.I.

    2012-01-01

    A new EAS Cherenkov light array, Tunka-133, with ∼1km 2 geometrical area has been installed at the Tunka Valley (50 km from Lake Baikal) in 2009. The array permits a detailed study of cosmic ray energy spectrum and mass composition in the energy range 10 16 –10 18 eV with a uniform method. We describe the array construction, DAQ and methods of the array calibration. The method of energy reconstruction and absolute calibration of measurements are discussed. The analysis of spatial and time structure of EAS Cherenkov light allows to estimate the depth of the EAS maximum X max . The results on the all particles energy spectrum and the mean depth of the EAS maximum X max vs. primary energy derived from the data of two winter seasons (2009–2011) are presented. Preliminary results of joint operation of the Cherenkov array with antennas for the detection of EAS radio signals are shown. Plans for future upgrades – deployment of remote clusters, radioantennas and a scintillator detector network and a prototype of the HiSCORE gamma-telescope – are discussed.

  4. EAS experiment on board the Airbus A380

    International Nuclear Information System (INIS)

    Capdevielle, J.N.; Cohen, F.; Jedrzejczak, K.; Szabelska, B.; Szabelski, J.; Wibig, T.

    2006-01-01

    We consider taking the opportunity of about 10,000 hours of test flights of the Airbus A380, and to install in the passenger area detectors for high energy cosmic ray events. The altitude of 10 km (250 g/cm 2 ) presents the opportunity to measure EAS originating from heavy primaries to energies exceeding 10 7 GeV, and also the proton component beyond the energy of the knee arriving without interaction. At the flight altitude iron originated EAS are well developed and by registering their lateral distribution in the 70 meters long cabin it will be possible to distinguish them from proton originated EAS. The hadron component of EAS (registered as number of secondary hadrons produced in the detector) would help in discrimination and energy estimation. On the other hand, the detection of high energy protons (without EAS) would enable us to measure the high energy proton spectrum. The proton energy would be estimated via hadron multiplicity in single interactions inside the detector. We propose to use about 60 modules of 0.5 m 2 of active detectors with scintillators to detect E-M component and a carbon target with lead layer to detect the hadronic component via neutron registrations

  5. Analysis of ethyl acrylate (EA) and acrylic acid (AA) residues from rat tissues following oral ea dosing

    International Nuclear Information System (INIS)

    Udinsky, J.R.; Frederick, C.B.

    1990-01-01

    Gavage dosing of rats with EA at high dose levels (100 or 200 mg/kg) has resulted in tumors at the dosing site, forestomach (FST), but no lesions of the glandular stomach (GST) or other remote tissues. Since previous in vitro studies have demonstrated that EA is very rapidly metabolized to AA and glutathione conjugates, EA and AA residues were analyzed 0-24 hr following gavage dosing of non-fasted F-344/N male rats with [1- 14 C]EA in corn oil at 10, 50, and 200 mg/kg. Analysis of total 14 C indicated that the dose solution was primarily in the FST at ≥5 min after dosing, although 14 C was detected in the GST, duodenum, and small intestine (attributed to distension of the FST and leakage from the FST to the GST). HPLC analysis of the gut contents, gut wall, liver, kidneys, lungs, and blood indicated that EA and AA could only be detected at ≥15 min in the FST and GST contents, and in the FST tissue. AA alone was detected in the GST tissue, duodenum tissue and contents, and small intestine tissue and contents. The minimum level of detection was 0.0005% of the dose. The remaining 14 C was primarily attributed to binding to the gut contents or bioincorporation of AA. The detection of EA and AA residues only in the upper gastrointestinal tract following gavage dosing is consistent with rapid detoxification of EA by hydrolysis and conjugation which prevents toxicity at sites remote form the site of dosing

  6. 47 CFR 11.54 - EAS operation during a National Level emergency.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false EAS operation during a National Level emergency... SYSTEM (EAS) Emergency Operations § 11.54 EAS operation during a National Level emergency. (a) The EAS Operating Handbook summarizes the procedures to be followed upon receipt of a National level EAN or EAT...

  7. D1.1 Stakeholders Needs Regarding EA

    DEFF Research Database (Denmark)

    Ryberg, Thomas; Eleftheriou, Paraskevi; Maglavera, Stavroula

    2009-01-01

    The objective of this deliverable is to identify and document the competences (skills and knowledge) that employees of both private and public sector organisations need to acquire in order to be capable of developing an EA as well as the competences that university students need to acquire in a u...... competences comprising professional skills, personal skills and knowledge. Finally, three detailed lists of EA related competences are presented for the three target groups of the project i.e. private sector employees, public sector employees and university students....

  8. (1+1) EA on Generalized Dynamic OneMax

    DEFF Research Database (Denmark)

    Kötzing, Timo; Lissovoi, Andrei; Witt, Carsten

    2015-01-01

    . We get tight bounds both for the case of bit strings, as well as for the case of more than two values per position. Surprisingly, in the latter setting, the expected quality of the search point maintained by the (1+1) EA does not depend on the number of values per dimension....... using the modern tool of drift analysis. We extend these results to search spaces which allow for more than two values per dimension. Furthermore, we make an anytime analysis as suggested by Jansen and Zarges (2014), analyzing how closely the (1+1) EA can track the dynamically moving optimum over time...

  9. Trends in Governmental Enterprise Architecture: Reviewing National EA Programs

    DEFF Research Database (Denmark)

    Gøtze, John; Christiansen, Peter Engelund

    2007-01-01

    This article is the first in a series of three, where we will analyze and evaluate governmental enterprise architecture policies and practices from an international perspective. This first article presents the overall findings from an international study, we have made about governmental EA, and i...

  10. A new paradigm for Environmental Assessment (EA) in Korea

    International Nuclear Information System (INIS)

    Song, Young-Il; Glasson, John

    2010-01-01

    Over the last 30 years, Environmental Impact Assessment (EIA) in Korea has played an important role in decision-making processes particularly for environmentally sensitive projects. However, the EIA system alone has sometimes not been effective enough to ensure the successful resolution of environmental concerns. In order to compensate for the limitations of the EIA system, a new assessment system called Prior Environmental Review System (PERS), which is relevant to Strategic Environmental Assessment (SEA) in some aspects, was introduced in 1993. PERS aims to balance development and preservation by identifying possible environmental impacts of some administrative plans mainly related to development projects in the early stages of planning. However, PERS still appeared to have some weak points such as a limited range of subjects to be assessed, and weakness of tiering (or vertical integration) from PERS to EIA. Therefore, the necessity for reform of the Korean Environmental Assessment (EA) system, including PERS, was raised. In response, the Korean government sought to establish its policy direction for implementing SEA by enhancing the objectivity and expertise of PERS. The policy was approved by the National Assembly in May 2005, and went into effect in June 2006. The introduction of SEA, by enhancing PERS, provides a framework for a system of EA from the strategic level, including PPPs, to the project level. Yet, despite such improvements, some managerial and technical problems associated with subsequent EA implementation remain. This paper critically reviews the evolution of the EA system in Korea and suggests essential improvements for the current EA system based on experiences of implementation of both EIA and SEA since June 2006, in the context of international good practice.

  11. The Importance of Being ‘On the Road’: A Reading of the Journey in The Darjeeling Limited (2007 by Wes Anderson

    Directory of Open Access Journals (Sweden)

    José Duarte

    2015-06-01

    Full Text Available Road stories are significant cultural objects that “provide a ready space for [the] exploration” (Cohan and Hark 1997, 2 of different landscapes, contributing to the encounter of the traveller with him/herself or with the Other. These cultural encounters offer the opportunity both for inner reflection upon the nation in which the protagonists travel. Such is the case of the Whitman brothers in The Darjeeling Limited (2007, Wes Anderson, who embark on a journey in India, seeking spiritual enlightenment from the problems of the past. The confrontation with the foreign Other will not only put into perspective a changed notion of the Indian nation but also their true purpose in life. Based upon the idea of the transformative power of journeys, and considering The Darjeeling Limited as a road movie, this article analyzes the brothers’ awakening as they travel deeper into the Indian landscape to emerge with a renewed sense of self.

  12. [A sporadic case of episodic ataxia with nystagmus (EA-2)].

    Science.gov (United States)

    Namekawa, M; Takiyama, Y; Ueno, N; Nishizawa, M

    1998-05-01

    A 39-year-old man with episodic ataxia with nystagmus (EA-2) was reported. He showed intermittent cerebellar dysfunction, i.e., ataxia, nystagmus, dysarthria and vertigo, since he was 10 years old. Although this attack lasted for several hours, he was normal with exception of interictal nystagmus. His parents and sister showed no episodic ataxia. We ruled out the diseases, which may cause episodic ataxia, such as multiple sclerosis, vascular disorders, metabolic disorders and congenital anomalies. He was released from the attack by treatment with acetazolamide. EA-2 has been associated with mutations in the alpha 1A-voltage dependent calcium channel gene (CACNL1A4), which is also affected in familial hemiplegic migraine (FMH) and spinocerebellar ataxia type 6 (SCA6). In EA-2, frame-shift mutation leading to premature stop and splice-site mutation leading to truncated, non-functional channel protein have been reported. However, our patient did not have the mutations in the CACNL1A4 gene that were previously reported. In addition, our patient did not have an expanded CAG allele in the CACNL1A4 gene which is responsible for SCA6. Further examination is required to address whether a new mutation exists in the CACNL1A4 gene in our patient.

  13. 47 CFR 90.691 - Emission mask requirements for EA-based systems.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emission mask requirements for EA-based systems. 90.691 Section 90.691 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... of Ea-Based Smr Systems in the 809-824/851-869 Mhz Band § 90.691 Emission mask requirements for EA...

  14. Physical Properties and Evolutionary States of EA-type Eclipsing Binaries Observed by LAMOST

    Science.gov (United States)

    Qian, S.-B.; Zhang, J.; He, J.-J.; Zhu, L.-Y.; Zhao, E.-G.; Shi, X.-D.; Zhou, X.; Han, Z.-T.

    2018-03-01

    About 3196 EA-type binaries (EAs) were observed by LAMOST by 2017 June 16 and their spectral types were derived. Meanwhile, the stellar atmospheric parameters of 2020 EAs were determined. In this paper, those EAs are cataloged and their physical properties and evolutionary states are investigated. The period distribution of EAs suggests that the period limit of tidal locking for the close binaries is about 6 days. It is found that the metallicity of EAs is higher than that of EW-type binaries (EWs), indicating that EAs are generally younger than EWs and they are the progenitors of EWs. The metallicities of long-period EWs (0.4values of Log (g) are usually smaller than those of EAs. These support the evolutionary process that EAs evolve into long-period EWs through the combination of angular momentum loss (AML) via magnetic braking and case A mass transfer. For short-period EWs, their metallicities are lower than those of EAs, while their gravitational accelerations are higher. These reveal that they may be formed from cool short-period EAs through AML via magnetic braking with little mass transfer. For some EWs with high metallicities, they may be contaminated by material from the evolution of unseen neutron stars and black holes or they have third bodies that may help them to form rapidly through a short timescale of pre-contact evolution. The present investigation suggests that the modern EW populations may have formed through a combination of these mechanisms.

  15. Design and research on nuclear power plant EAS jet pump

    International Nuclear Information System (INIS)

    Chen Xingjiang; Fang Xiquan; Xie Jian; Yang Bin; Wang Xueling; Qi Yanli

    2014-01-01

    The jet pump is an important part of the PWR containment spray system. It will be performed the security functions under the accident conditions, which the containment spray system adds the right amount of sodium hydroxide through the jet pump to spray water. This paper describes the principle of jet pump. And the optimum structure dimensions were calculated according to the performance parameter and requirement of the jet pump. On the basis of foreign EAS jet pump design experience, the structure dimensions were modified according to the CFD analysis and performance test. Finally, the results of CFD analysis and performance test were provided. (authors)

  16. Expert Advisor (EA) Evaluation System Using Web-based ELECTRE Method in Foreign Exchange (Forex) Market

    Science.gov (United States)

    Satibi; Widodo, Catur Edi; Farikhin

    2018-02-01

    This research aims to optimize forex trading profit automatically using EA but its still keep considering accuracy and drawdown levels. The evaluation system will classify EA performance based on trading market sessions (Sydney, Tokyo, London and New York) to determine the right EA to be used in certain market sessions. This evaluation system is a web-based ELECTRE methods that interact in real-time with EA through web service and are able to present real-time charts performance dashboard using web socket protocol communications. Web applications are programmed using NodeJs. In the testing period, all EAs had been simulated 24 hours in all market sessions for three months, the best EA is valued by its profit, accuracy and drawdown criteria that calculated using web-based ELECTRE method. The ideas of this research are to compare the best EA on testing period with collaboration performances of each best classified EA by market sessions. This research uses three months historical data of EUR/USD as testing period and other 3 months as validation period. As a result, performance of collaboration four best EA classified by market sessions can increase profits percentage consistently in testing and validation periods and keep securing accuracy and drawdown levels.

  17. Expert Advisor (EA Evaluation System Using Web-based ELECTRE Method in Foreign Exchange (Forex Market

    Directory of Open Access Journals (Sweden)

    Satibi Satibi

    2018-01-01

    Full Text Available This research aims to optimize forex trading profit automatically using EA but its still keep considering accuracy and drawdown levels. The evaluation system will classify EA performance based on trading market sessions (Sydney, Tokyo, London and New York to determine the right EA to be used in certain market sessions. This evaluation system is a web-based ELECTRE methods that interact in real-time with EA through web service and are able to present real-time charts performance dashboard using web socket protocol communications. Web applications are programmed using NodeJs. In the testing period, all EAs had been simulated 24 hours in all market sessions for three months, the best EA is valued by its profit, accuracy and drawdown criteria that calculated using web-based ELECTRE method. The ideas of this research are to compare the best EA on testing period with collaboration performances of each best classified EA by market sessions. This research uses three months historical data of EUR/USD as testing period and other 3 months as validation period. As a result, performance of collaboration four best EA classified by market sessions can increase profits percentage consistently in testing and validation periods and keep securing accuracy and drawdown levels.

  18. Chemical and physical oceanographic profile data collected from CTD casts aboard the Wes Bordelon in the Gulf of Mexico from 2010-09-05 to 2010-09-13 in response to the Deepwater Horizon oil spill event (NODC Accession 0069085)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and physical oceanographic profile data were collected aboard the Wes Bordelon in the Gulf of Mexico from 2010-09-05 to 2010-09-13 in response to the...

  19. Chemical and physical oceanographic profile data collected from CTD casts aboard the Wes Bordelon in the Gulf of Mexico from 2010-08-18 to 2010-08-22 in response to the Deepwater Horizon oil spill event (NODC Accession 0069086)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Chemical and physical oceanographic profile data were collected aboard the Wes Bordelon in the Gulf of Mexico from 2010-08-18 to 2010-08-22 in response to the...

  20. 47 CFR 1.1311 - Environmental information to be included in the environmental assessment (EA).

    Science.gov (United States)

    2010-10-01

    ... a residential area, the EA must also address the impact of this lighting upon the residents. (2) A... concerning the proposal's environmental impact, if any. The EA shall deal specifically with any feature of... land utilized (e.g., deforestation, water diversion, wetland fill, or other extensive change of surface...

  1. 7 CFR 1955.136 - Environmental Assessment (EA) and Environmental Impact Statement (EIS).

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Environmental Assessment (EA) and Environmental Impact... Disposal of Inventory Property General § 1955.136 Environmental Assessment (EA) and Environmental Impact Statement (EIS). (a) Prior to a final decision on some disposal actions, an environmental assessment must be...

  2. 75 FR 33799 - EasTrans, LLC; Notice of Baseline Filing

    Science.gov (United States)

    2010-06-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-30-000] EasTrans, LLC; Notice of Baseline Filing June 8, 2010. Take notice that on June 4, 2010, EasTrans, LLC submitted a baseline filing of its Statement of Operating Conditions for services provided under section 311 of the...

  3. MODELING AND DESIGN STUDY USING HFC-236EA AS AN ALTERNATIVE REFRIGERANT IN A CENTRIFUGAL COMPRESSOR

    Science.gov (United States)

    The report gives results of an investigation of the operation of a centrifugal compressor--part of a chlorofluorocarbon (CFC)-114 chiller installation--with the new refrigerant hydrofluorocarbon (HFC)-236ea, a proposed alternative to CFC-114. A large set of CFC-236ea operating da...

  4. REDES TECNOLÓGICAS APLICADAS EM EaD

    Directory of Open Access Journals (Sweden)

    Suélly Lima dos Santos

    2011-08-01

    Full Text Available Com o advento da internet e o aparecimento das novas tecnologias educacionais, conjunto de informações e comunicações (telefone, internet, rádio, vídeo, computador e televisão, ultrapassaram as fronteiras das quatro paredes da sala de aula, surgindo ambientes virtuais direcionadas à ampliação da participação dos serviços públicos relacionados ao ensino. À educação e à formação técnica e profissional permitiu-se o aumento da interatividade através da tecnologia, promovendo maneiras de acesso ao aluno utilizando computadores e/ou dispositivos móveis que viabiliza a Educação à Distância (EaD. Devido o grande crescimento do ensino à distância, as instituições já utilizam redes de dados para ampliar o acesso de aprendizagem. Com este espantoso aumento das redes, e da acelerada transmissão de informações aprender como elas funcionam é muito importante, além do mais usando a própria tecnologia para este fim. Como conclusão deste trabalho as mudanças relâmpadas da grande disponibilidade de dados no ambiente virtual é de enorme valia para o processo ensino-aprendizado.

  5. EA follow-up in the Ghanaian mining sector: Challenges and opportunities

    International Nuclear Information System (INIS)

    Appiah-Opoku, Seth; Bryan, Hobson C.

    2013-01-01

    Environmental assessment (EA) follow-up provides a means for monitoring and evaluating the implementation of environmental impact studies. It is integral to the success or failure of a project or program. In spite of its importance, very little attention is given to the need for follow-up programs in most jurisdictions in Africa. Using a case study in the Ghanaian mining sector, this paper explores the challenges and opportunities within the country's EA process for an effective follow-up program. The paper is based on informal interviews, content analysis of relevant publications, official EA documents, and internet searches. The authors suggest a standard EA follow-up program to be formalized as an integral part of Ghana's environmental assessment policy. They also propose a follow-up process that harnesses existing opportunities within the country's EA system. This approach can be replicated in other African countries

  6. Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea

    International Nuclear Information System (INIS)

    Poudel, Bhawana; Bilbao, Daniel; Sarathchandra, Padmini; Germack, Renee; Rosenthal, Nadia; Santini, Maria Paola

    2011-01-01

    Highlights: ► In this study, we explored the function of IGF-1Ea propeptide in inducing cardiogenesis of stem cells. ► IGF-1Ea promoted cardiac mesodermal induction in uncommitted cells. ► Under differentiation condition, IGF-1Ea increased expression of cardiac differentiation markers. ► Furthermore, it promoted formation of finely organized sarcomeric structure. ► IGF-1Ea propeptide may be a good candidate to improve production of cardiomyocytes from pluripotent cells. -- Abstract: The mechanism implicated in differentiation of endogenous cardiac stem cells into cardiomyocytes to regenerate the heart tissue upon an insult remains elusive, limiting the therapeutical goals to exogenous cell injection and/or gene therapy. We have shown previously that cardiac specific overexpression of the insulin-like growth factor 1 propeptide IGF-1Ea induces beneficial myocardial repair after infarct. Although the mechanism is still under investigation, the possibility that this propeptide may be involved in promoting stem cell differentiation into the cardiac lineage has yet to be explored. To investigate whether IGF-1Ea promote cardiogenesis, we initially modified P19 embryonal carcinoma cells to express IGF-1Ea. Taking advantage of their cardiomyogenic nature, we analyzed whether overexpression of this propeptide affected cardiac differentiation program. The data herein presented showed for the first time that constitutively overexpressed IGF-1Ea increased cardiogenic differentiation program in both undifferentiated and DMSO-differentiated cells. In details, IGF-1Ea overexpression promoted localization of alpha-actinin in finely organized sarcomeric structure compared to control cells and upregulated the cardiac mesodermal marker NKX-2.5 and the ventricular structural protein MLC2v. Furthermore, activated IGF-1 signaling promoted cardiac mesodermal induction in undifferentiated cells independently of cell proliferation. This analysis suggests that IGF-1Ea may be a

  7. Runtime analysis of the (1+1) EA on computing unique input output sequences

    DEFF Research Database (Denmark)

    Lehre, Per Kristian; Yao, Xin

    2010-01-01

    Computing unique input output (UIO) sequences is a fundamental and hard problem in conformance testing of finite state machines (FSM). Previous experimental research has shown that evolutionary algorithms (EAs) can be applied successfully to find UIOs for some FSMs. However, before EAs can...... in the theoretical analysis, and the variability of the runtime. The numerical results fit well with the theoretical results, even for small problem instance sizes. Together, these results provide a first theoretical characterisation of the potential and limitations of the (1 + 1) EA on the problem of computing UIOs....

  8. Posterior Tracheopexy for Severe Tracheomalacia Associated with Esophageal Atresia (EA: Primary Treatment at the Time of Initial EA Repair versus Secondary Treatment

    Directory of Open Access Journals (Sweden)

    Hester F. Shieh

    2018-01-01

    Full Text Available PurposeWe review outcomes of posterior tracheopexy for tracheomalacia in esophageal atresia (EA patients, comparing primary treatment at the time of initial EA repair versus secondary treatment.MethodsAll EA patients who underwent posterior tracheopexy from October 2012 to September 2016 were retrospectively reviewed. Clinical symptoms, tracheomalacia scores, and persistent airway intrusion were collected. Indication for posterior tracheopexy was the presence of clinical symptoms, in combination with severe tracheomalacia as identified on bronchoscopic evaluation, typically defined as coaptation in one or more regions of the trachea. Secondary cases were usually those with chronic respiratory symptoms who underwent bronchoscopic evaluation, whereas primary cases were those found to have severe tracheomalacia on routine preoperative dynamic tracheobronchoscopy at the time of initial EA repair.ResultsA total of 118 patients underwent posterior tracheopexy: 18 (15% primary versus 100 (85% secondary cases. Median (interquartile range age was 2 months (1–4 months for primary (22% type C and 18 months (8–40 months for secondary (87% type C cases (p < 0.001. There were statistically significant improvements in most clinical symptoms postoperatively for primary and secondary cases, with no significant differences in any postoperative symptoms between the two groups (p > 0.1. Total tracheomalacia scores improved significantly in primary (p = 0.013 and secondary (p < 0.001 cases. Multivariable Cox regression analysis indicated no differences in persistent airway intrusion requiring reoperation between primary and secondary tracheopexy adjusting for imbalances in age and EA type (p = 0.67.ConclusionPosterior tracheopexy is effective in treating severe tracheomalacia with significant improvements in clinical symptoms and degree of airway collapse on bronchoscopy. With no significant differences in outcomes between primary and

  9. Synthesis and optimization of EA-MMA copolymer emulsion%EA-MMA共聚乳液合成工艺及优化

    Institute of Scientific and Technical Information of China (English)

    张成芬; 武玉民

    2011-01-01

    以丙烯酸乙酯(EA)和甲基丙烯酸甲酯(MMA)为共聚单体、过硫酸钾(KPS)为引发剂、十二烷基硫酸钠(SDS)和壬基酚聚氧乙烯醚(OP-10)为复合乳化剂,采用乳液聚合法合成出一种稳定的EA-MMA乳液.通过单因素试验法考察了乳化剂浓度、引发剂浓度、反应温度和反应时间等因素对乳液平均粒径和单体转化率的影响,并采用正交试验法进一步优选出制备EA-MMA乳液的最佳工艺条件.结果表明:当w(乳化剂)=2.0%、w(引发剂)=0.60%、反应时间为4 h和反应温度为80℃时,制成的EA-MMA乳液较稳定,并且单体转化率相对最高.%With ethyl acrylate(EA) and methyl methacrylate( MMA) as comonomers ,potassium persulfate(KPS)as initiator,and sodium dodecyl sulfate(SDS) and nonylphenol ethoxylates(OP-10) as composite emulsifier,a stable EA-MMA emulsion was synthesized by emulsion polymerization. The influences of some factor(such as emulsifier concentration,initiator concentration,reaction temperature and reaction time) on average particle size of emulsion and monomer conversion rate were investigated by single factor experiment method,then the optimal process conditions of preparing EA-MMA emulsion were preferred by orthogonal experiment method. The results showed that the EA-MMA emulsion had better stability and relatively highest monomer conversion rate when the mass fractions of emulsifier and initiator were 2.0% and 0.60% respectively,the reaction time and reaction temperature were 4 h and 80 ℃ respectively.

  10. Inclusive pseudodata for eA collisions at the LHeC

    CERN Document Server

    Armesto, N

    2010-01-01

    I explain how the pseudodata for eA collisions are generated, for the reduced cross section, $F_2$, $F_L$ and the corresponding heavy flavor decompositions. I also discuss how the uncertainties are computed.

  11. 47 CFR 11.55 - EAS operation during a State or Local Area emergency.

    Science.gov (United States)

    2010-10-01

    ..., earthquakes, heavy snows, icing conditions, widespread fires, etc. Man-made emergencies may include: toxic gas...) SDARS licensees and DBS providers may participate in EAS at the state and local level and make their...

  12. Harlamov selgitab EAS-i nõukogule BNS-ist lahkumist / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2005-01-01

    Ettevõtluse Arendamise Sihtasutuse juhatuse esimehe kandidaadilt Oleg Harlamovilt, praeguselt majandus- ja kommunikatsiooniminister Edgar Savisaare nõunikult, plaanitakse küsida tema BNS-ist lahkumise kohta. Lisa: Varrak: EAS pole kellegi rahapump

  13. Slow and fast light in SOA-EA structures for phased-array antennas

    DEFF Research Database (Denmark)

    Sales, S.; Öhman, Filip; Bermejo, A.

    We present an SOA-EA structure for controlling the phase and amplitude of optically fed phased-array antennas. Phase shifts of 40 degrees are obtained through slow and fast light effects by changing only the reverse voltage....

  14. Business Architecture Development at Public Administration - Insights from Government EA Method Engineering Project in Finland

    Science.gov (United States)

    Valtonen, Katariina; Leppänen, Mauri

    Governments worldwide are concerned for efficient production of services to customers. To improve quality of services and to make service production more efficient, information and communication technology (ICT) is largely exploited in public administration (PA). Succeeding in this exploitation calls for large-scale planning which embraces issues from strategic to technological level. In this planning the notion of enterprise architecture (EA) is commonly applied. One of the sub-architectures of EA is business architecture (BA). BA planning is challenging in PA due to a large number of stakeholders, a wide set of customers, and solid and hierarchical structures of organizations. To support EA planning in Finland, a project to engineer a government EA (GEA) method was launched. In this chapter, we analyze the discussions and outputs of the project workshops and reflect emerged issues on current e-government literature. We bring forth insights into and suggestions for government BA and its development.

  15. Measurable difference in Cherenkov light between gamma and hadron induced EAS

    Energy Technology Data Exchange (ETDEWEB)

    Cabot, H.; Meynadier, Ch. [Universite de Perpignan, Groupe de Physique Fondamentale, Perpignan (France); Sobczynska, D. [Experimental Physics Department, University of Lodz, Lodz (Poland); Szabelska, B. [Soltan Institute for Nuclear Studies, Lodz (Poland); Szabelski, J. [Universite de Perpignan, Groupe de Physique Fondamentale, Perpignan (France)]|[Soltan Institute for Nuclear Studies, Lodz (Poland); Wibig, T. [Experimental Physics Department, University of Lodz, Lodz (Poland)

    1997-12-31

    We describe the possibly measurable difference in the Cherenkov light component of EAS induced by en electromagnetic particle (i.e. e{sup +}, e{sup -} or {gamma}) and induced by a hadron (i.e. proton or heavier nuclei) in TeV range. The method can be applied in experiments which use wavefront sampling method of EAS Cherenkov light detection (e.g. THEMISTOCLE, ASGAT). (author) 16 refs, 9 figs

  16. Classification of EA1-box proteins and new insights into their role during reproduction in grasses.

    Science.gov (United States)

    Uebler, Susanne; Márton, Mihaela L; Dresselhaus, Thomas

    2015-12-01

    EA1-box protein classification. Success in reproduction and vegetative development in flowering plants strongly depends on precise cell-to-cell signaling events mediated by secreted peptides.A small peptide family named as EA1-like (EAL) has been first described 10 years ago and includes EA1 involved in pollen tubes attraction by the female gametophyte and EAL1-regulating germ cell identity in maize. EALs consist of an N-terminal endoplasmic reticulum-targeting motif, the highly conserved EA1-box and a short C-terminal alanine-rich domain. Whereas EAL peptides are exclusively found in the Gramineae, the EA1-box is widely distributed throughout the plant kingdom. Based on in silico analysis and subcellular localization studies, we report here a new classification of EA1-box proteins in flowering plants. They can be distinguished into three protein classes: the already defined EAL proteins, the EAG (EA1-box glycine-rich) proteins and the EAC (EA1-box containing)proteins. While fusion proteins of EAL and EAC classes locate to the secretory pathway, EAGs are cytoplasmic and locate also to the nucleus. Moreover, we further show that the third EAL protein of Zea mays, EAL2, appears to be also involved in processes related to late embryogenic development as its peptide level increases after formation of leaf primordia. Immunohistochemical studies indicate its presence in the scutellar parenchyma and around the vasculature, where it is secreted to the extracellular space. In conclusion, the members of the maize EAL family possess very diverse functions during reproduction and it will now be exciting to elucidate the functions of EAGs and EACs in plants.

  17. Digitaalisen markkinointiviestinnän mahdollisuudet : Case Kelloliike EA Lahti Oy

    OpenAIRE

    Harmaala, Tiina

    2011-01-01

    TIIVISTELMÄ Harmaala, Tiina. 2011. Digitaalisen markkinointiviestinnän mahdollisuudet – Case Kelloliike EA Lahti Oy. Opinnäytetyö. Kemi-Tornion ammattikorkeakoulu. Kaupan ja kulttuurin toimiala. Sivuja 62. Opinnäytetyön tavoitteena on Kelloliike EA Lahti Oy:n digitaalisen markkinointiviestinnän suunnittelu. Tutkimuksessa tarkastelen digitaalista markkinointiviestintää integroidun markkinointiviestinnän näkökulmasta. Tutkimuksen tarkoituksena on selvittää toimeksiantajalle sen markkino...

  18. A New Kind of Void Soap-free P(MMA-EA-MAA) Latex Particles

    Institute of Scientific and Technical Information of China (English)

    Kai KANG; Cheng You KAN; Yi DU; Yu Zhong LI; De Shan LIU

    2005-01-01

    Soap-free P(MMA-EA-MAA) particles with narrow size distribution were synthesized by seeded emulsion polymerization of methyl methacrylate (MMA), ethyl acrylate (EA) and methacrylic acid (MAA), and large voids inside the particles were generated by alkali posttreatment in the presence of 2-butanone. Results indicated that the size of void and the particle volume were related with the amount of 2-butanone. The generation mechanism of voids was proposed.

  19. Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea

    Energy Technology Data Exchange (ETDEWEB)

    Poudel, Bhawana [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom); Bilbao, Daniel [EMBL, Mouse Biology Unit, Monterotondo (Italy); Sarathchandra, Padmini; Germack, Renee [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom); Rosenthal, Nadia [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom); Australian Regenerative Medicine Institute, Monash University, Melbourne (Australia); Santini, Maria Paola, E-mail: m.santini@imperial.ac.uk [Heart Science Centre, National Heart and Lung Institute, Imperial College, London (United Kingdom)

    2011-12-16

    Highlights: Black-Right-Pointing-Pointer In this study, we explored the function of IGF-1Ea propeptide in inducing cardiogenesis of stem cells. Black-Right-Pointing-Pointer IGF-1Ea promoted cardiac mesodermal induction in uncommitted cells. Black-Right-Pointing-Pointer Under differentiation condition, IGF-1Ea increased expression of cardiac differentiation markers. Black-Right-Pointing-Pointer Furthermore, it promoted formation of finely organized sarcomeric structure. Black-Right-Pointing-Pointer IGF-1Ea propeptide may be a good candidate to improve production of cardiomyocytes from pluripotent cells. -- Abstract: The mechanism implicated in differentiation of endogenous cardiac stem cells into cardiomyocytes to regenerate the heart tissue upon an insult remains elusive, limiting the therapeutical goals to exogenous cell injection and/or gene therapy. We have shown previously that cardiac specific overexpression of the insulin-like growth factor 1 propeptide IGF-1Ea induces beneficial myocardial repair after infarct. Although the mechanism is still under investigation, the possibility that this propeptide may be involved in promoting stem cell differentiation into the cardiac lineage has yet to be explored. To investigate whether IGF-1Ea promote cardiogenesis, we initially modified P19 embryonal carcinoma cells to express IGF-1Ea. Taking advantage of their cardiomyogenic nature, we analyzed whether overexpression of this propeptide affected cardiac differentiation program. The data herein presented showed for the first time that constitutively overexpressed IGF-1Ea increased cardiogenic differentiation program in both undifferentiated and DMSO-differentiated cells. In details, IGF-1Ea overexpression promoted localization of alpha-actinin in finely organized sarcomeric structure compared to control cells and upregulated the cardiac mesodermal marker NKX-2.5 and the ventricular structural protein MLC2v. Furthermore, activated IGF-1 signaling promoted cardiac

  20. Time for a new approach to public participation in EA: Promoting cooperation and consensus for sustainability

    International Nuclear Information System (INIS)

    Doelle, Meinhard; Sinclair, A. John

    2006-01-01

    One of the fundamental challenges of project-based environmental assessments (EA) has been to deliver on the promise of meaningful public participation leading to decisions that put affected societies on the path to sustainability. The record to date has been less than promising, leading the authors to propose that it is time to consider a different approach to legislating public participation in project assessments, one that starts with the ultimate objective of cooperation and consensus building. The authors work back from this objective and propose an EA process specifically designed to encourage all participants to participate constructively. In the process, the authors identify how the proposed process will address various criticisms made of the traditional approach to EA by proponents, government officials and members of the public alike. Through a fundamental shift from process requirements to a focus on the outcomes of EA, the authors propose a way forward for project-based EA to deliver on the promise of becoming a central tool on the path to sustainability

  1. Isolation and characterization of new lignin streams derived from extractive-ammonia (EA) pretreatment

    Energy Technology Data Exchange (ETDEWEB)

    da Costa Sousa, Leonardo [Michigan State Univ., East Lansing, MI (United States); Foston, Marcus [Washington Univ., St. Louis, MO (United States); Bokade, Vijay [National Chemical Lab., Pune (India); Azarpira, Ali [Univ. of Wisconsin, Madison, WI (United States); Lu, Fachuang [Univ. of Wisconsin, Madison, WI (United States); Ragauskas, Arthur J. [Univ. of Tennessee, Knoxville, TN (United States); Ralph, John [Univ. of Wisconsin, Madison, WI (United States); Dale, Bruce [Michigan State Univ., East Lansing, MI (United States); Balan, Venkatesh [Michigan State Univ., East Lansing, MI (United States)

    2016-05-05

    One of the key challenges facing lignin conversion to fuels and chemicals is related to the level of carbohydrate and ash impurities found in extracted lignin. Structural modifications of lignin may also occur as a result of biomass pretreatment and harsh lignin extraction protocols. Extractive-Ammonia (EA) is a new pretreatment technology that uses liquid ammonia to cleave lignin–carbohydrate complexes, decrystallize cellulose, solubilize lignin, and selectively extract lignin from lignocellulosic biomass, enabling better utilization of both lignin and carbohydrate components in a biorefinery. The EA-based biorefinery produces two different lignin-rich streams, with different properties, that could potentially be upgraded to fuels and chemicals using green processes. Here, a water/ethanol-based fractionation method was developed to enrich the ammonia-soluble extractives, resulting in a major product stream containing 92% lignin. Detailed characterization of the various streams resulting from EA treatment, including compositional analysis, structural characterization by nuclear magnetic resonance (NMR) spectrometry, elemental analysis, molecular weight analysis, and thermo-gravimetric analysis provides a broad evaluation of the EA-derived lignin product stream structures and properties, assessing their potential for commercial applications. In conclusion, EA-derived lignins preserve much of lignin's functionality, including the sensitive β-aryl ether units. Furthermore, we observed nitrogen incorporation in the lignin-rich streams, notably due to the presence of hydroxycinnamoyl amides formed during ammonia pretreatment.

  2. Optimal mutation rates for the (1+λ) EA on OneMax

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2016-01-01

    We study the (1 + λ) EA with mutation probability c/n, where c > 0 is a constant, on the ONEMAX problem. Using an improved variable drift theorem, we show that upper and lower bounds on the expected runtime of the (1+λ) EA obtained from variable drift theorems are at most apart by a small lower...... mutation rates for the (1+λ) EA for various parameter settings of c and λ and also for moderate sizes of n. This makes the need for potentially lengthy and costly experiments in order to optimize the parameters unnecessary. Interestingly, even for moderate n and not too small λ it turns out that mutation...... rates up to 10% larger than the asymptotically optimal rate 1/n minimize the expected runtime. However, in absolute terms the expected runtime does not change by much when replacing 1/n with the optimal mutation rate....

  3. E+A galaxies in the SDSS. Stellar population and morphology

    Science.gov (United States)

    Leiva, R.; Galaz, G.

    2014-10-01

    Galaxies with E+A spectrum have deep Balmer absorption and no H_{α} and [OII] emission. This suggest recent star formation and the lack of ongoing star formation. With an E+A sample from the SDSS DR 7 (Aihara et al. 2011) we study the morphology with Galaxy Zoo 1 data and the star formation history fitting models from Bruzual & Charlot (2003). We found an underpopulation of spiral and disk like galaxies and an overpopulation of interacting galaxies, the last seems consistent with the scenario where, at low z, the interaction mechanism is responsible for at least part of the E+A galaxies. The star formation history (SFH) fits most of the spectra indicating an increased star formation around 2 Gyr in the past. Additional parameters like dust internal extinction need to be included to improve the fitting.

  4. Self-Adaptive Operator Scheduling using the Religion-Based EA

    DEFF Research Database (Denmark)

    Thomsen, Rene; Krink, Thiemo

    2002-01-01

    of their application is determined by a constant parameter, such as a fixed mutation rate. However, recent studies have shown that the optimal usage of a variation operator changes during the EA run. In this study, we combined the idea of self-adaptive mutation operator scheduling with the Religion-Based EA (RBEA......), which is an agent model with spatially structured and variable sized subpopulations (religions). In our new model (OSRBEA), we used a selection of different operators, such that each operator type was applied within one specific subpopulation only. Our results indicate that the optimal choice...

  5. A Combined group EA-PROMETHEE method for a supplier selection problem

    Directory of Open Access Journals (Sweden)

    Hamid Reza Rezaee Kelidbari

    2016-07-01

    Full Text Available One of the important decisions which impacts all firms’ activities is the supplier selection problem. Since the 1950s, several works have addressed this problem by treating different aspects and instances. In this paper, a combined multiple criteria decision making (MCDM technique (EA-PROMETHEE has been applied to implement a proper decision making. To this aim, after reviewing the theoretical background regarding to supplier selection, the extension analysis (EA is used to determine the importance of criteria and PROMETHEE for appraisal of suppliers based on the criteria. An empirical example illustrated the proposed approach.

  6. Crack closure in near-threshold fatigue crack propagation in railway axle steel EA4T

    Czech Academy of Sciences Publication Activity Database

    Pokorný, Pavel; Vojtek, Tomáš; Náhlík, Luboš; Hutař, Pavel

    2017-01-01

    Roč. 185, NOV (2017), s. 2-19 ISSN 0013-7944 R&D Projects: GA MŠk(CZ) LQ1601 Institutional support: RVO:68081723 Keywords : Fatigue crack propagation * crack closure * EA4T * Railway axle Subject RIV: JL - Materials Fatigue, Friction Mechanics OBOR OECD: Audio engineering , reliability analysis Impact factor: 2.151, year: 2016

  7. HEAT TRANSFER EVALUATION OF HFC-236EA WITH HIGH PERFORMANCE ENHANCED TUBES IN CONDENSATION AND EVAPORATION

    Science.gov (United States)

    The report gives results of an evaluation of the heat transfer performance of pure hydrofluorocarbon (HFC)-236ea for high performance enhanced tubes which had not been previously used in Navy shipboard chillers. Shell-side heat transfer coefficient data are presented for condensa...

  8. HEAT TRANSFER EVALUATION OF HFC-236EA AND CFC-114 IN CONDENSATION AND EVAPORATION

    Science.gov (United States)

    The report gives results of a heat transfer evaluation of the refrigerants hexafluoropropane (HFC-236ea) and 1,1,2,2-dichloro-tetrafluoroethane (CFC-114). (NOTE: With the mandatory phase-out of chlorofluorocarbons (CFCs), as dictated by the Montreal Protocol and Clean Air Act Ame...

  9. 47 CFR 11.51 - EAS code and Attention Signal Transmission requirements.

    Science.gov (United States)

    2010-10-01

    ... interfere with other visual messages. (e) Analog class D non-commercial educational FM stations as defined in § 73.506 of this chapter, digital class D non-commercial educational FM stations, analog Low Power... Message (EOM) codes using the EAS Protocol. The Attention Signal must precede any emergency audio message...

  10. Proyecto de Obras de Urbanización de la UD-EA1 Tm Murcia

    OpenAIRE

    Lafuente Pérez, Antonio

    2016-01-01

    El presente proyecto tiene por objeto la construcción de las obras de urbanización (viales, zonas verdes y servicios de abastecimiento y saneamiento) de la UD-EA1 del PGOUM. Escuela de Ingeniería de Caminos y Minas Universidad Politécnica de Cartagena

  11. Utility of 64-row MDCT in assessment of neonates with congenital EA and distal TEF

    Directory of Open Access Journals (Sweden)

    Hosam El-Deen Galal Mohamed El-Malah

    2015-12-01

    Conclusion: Preoperative MDCT scan with MPVR, 3D TL-VR of 64-row MDCT which is a noninvasive technique could provide more accurate information about the assessment of the origin of the fistula, the distal esophageal pouches and inter-pouch distance in neonates with EA and distal TEF.

  12. 75 FR 61345 - Airworthiness Directives; Eclipse Aerospace, Inc. Model EA500 Airplanes

    Science.gov (United States)

    2010-10-05

    ... Airworthiness Directives; Eclipse Aerospace, Inc. Model EA500 Airplanes AGENCY: Federal Aviation Administration... service information identified in this AD, contact Eclipse Aerospace Incorporated, 2503 Clark Carr Loop... Kinney, Aerospace Engineer, Ft. Worth Aircraft Certification Office, FAA, 2601 Meacham Blvd., Fort Worth...

  13. Spectrophotometric Properties of E+A Galaxies in SDSS-IV MaNGA

    Science.gov (United States)

    Marinelli, Mariarosa; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Johnson, Amalya; Kerrison, Nicole; Melchert, Nancy; Ojanen, Winonah; Weaver, Olivia; Liu, Charles; SDSS-IV MaNGA

    2018-01-01

    Quenched post-starburst galaxies, or E+A galaxies, represent a unique and informative phase in the evolution of galaxies. We used a qualitative rubric-based methodology, informed by the literature, to manually select galaxies from the SDSS-IV IFU survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) using the single-fiber spectra from the Sloan Digital Sky Survey Data Release 8. Of the 2,812 galaxies observed so far in MaNGA, we found 39 galaxies meeting our criteria for E+A classification. Spectral energy distributions of these 39 galaxies from the far-UV to the mid-infrared demonstrate a heterogeneity in our sample emerging in the infrared, indicating many distinct paths to visually similar optical spectra. We used SDSS-IV MaNGA Pipe3D data products to analyze stellar population ages, and found that 34 galaxies exhibited stellar populations that were older at 1 effective radius than at the center of the galaxy. Given that our sample was manually chosen based on E+A markers in the single-fiber spectra aimed at the center of each galaxy, our E+A galaxies may have only experienced their significant starbursts in the central region, with a disk of quenched or quenching material further outward. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  14. Separation and properties of EA-rosette-forming lymphocytes in humans

    NARCIS (Netherlands)

    van Oers, M. H.; Zeijlemaker, W. P.; Schellekens, P. T.

    1977-01-01

    Human peripheral blood lymphocytes were separated into subpopulations enriched or depleted with respect to B lymphocytes (Ig-bearing cells), T lymphocytes, (cell forming rosettes with sheep erythrocytes: E-RFC) and Fc receptor-bearing lymphocytes (EA-RFC). From the distributions and recoveries of

  15. 75 FR 62133 - Notice of Availability of Final Environmental Assessment (FINAL EA) and a Finding of No...

    Science.gov (United States)

    2010-10-07

    ... Availability of Final Environmental Assessment (FINAL EA) and a Finding of No Significant Impact (FONSI) for... of No Significant Impact (FONSI) for Land Purchase, Access Road Construction and Access Tunnel... Impact (FONSI) based on the Final Environmental Assessment (FINAL EA) for Land Purchase, Access Road...

  16. The Stellar Kinematics of E+A Galaxies in SDSS IV-MaNGA

    Science.gov (United States)

    Johnson, Amalya; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Kerrison, Nicole; Marinelli, Mariarosa; Melchert, Nancy; Ojanen, Winonah; Liu, Charles; SDSS-IV MaNGA

    2018-01-01

    E+A galaxies, hypothesized to be “transition” galaxies between the blue cloud and the red sequence, are valuable sources for studying the evolution of galaxies. Using data from the Sloan Digital Sky Survey Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, a large scale integral field spectroscopic survey of nearby galaxies from 3600 to 10300 Å, we identifed galaxies that exhibitted E+A characteristics within their optical spectra. We analyzed the 2,812 galaxies thus far observed by MaNGA to identify those that showed evidence of a starburst about 1 billion years ago, followed by cessation of star formation and quenching of the galaxy. Through this process we identifed 39 E+A galaxies by directly looking at the optical spectra and ensuring they exhibited the necessary properties of an E+A spectra, including a strong break at the 4000 Å mark, little to no Hα emission and absorption through the Balmer series, and a blue slope of the continuum past ~5000 Å as the flux decreases. We analyzed the stellar kinematics of these galaxies to determine whether or not they were fast or slow rotators, a proposed indicator of a major merger in their recent past. Using Voronoi binned graphs from the MaNGA Marvin database, we measured their stellar rotation curves in order to more clearly show the range of velocities within the galaxies. Among our 39 E+A candidates, all but two exhibited significant, orderly rotation across the galaxy, and 29 out of 39 of our galaxies show rotation faster than 30 km/s. With the caveat that our selection process was biased toward galaxies with orderly rotation, this prevalence of rotation challenges the belief that all E+A galaxies are created from major mergers. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  17. The time structure of the EAS muon component observed in the KASCADE experiment

    International Nuclear Information System (INIS)

    Brancus, I.M.; Badea, A.F.; Duma, M.; Vulpescu, B.; Rebel, H.; Haeusler, R.; Mathes, H.J.

    1998-01-01

    The determination of the chemical composition in the energy range of 10 15 eV is the scientific goal of the KASCADE (Karlsruhe Shower Core and Array Detector) experiment. Under this aspect, the temporal structure of the muon component of extended air showers (EAS) is of great interest for a detailed understanding of the EAS features, since the muon arrival time distribution maps the longitudinal EAS development via the time-of-flight of muons produced in large atmospheric heights and shows effects for mass discrimination of the EAS primaries. Using the muon detection and timing facilities of the KASCADE Central Detector, in particular the 'trigger' layer of 456 scintillation detectors and the position-sensitive large-area multiwire proportional chambers, installed under the hadron calorimeter, the muon arrival time distributions (E μ ≥ 2 GeV) registered relative to the arrival of the foremost muons have been measured. Their dependence on various shower quantities, the distance from the shower center R μ , the zenith angle Θ of shower incidence and muon shower content N μ tr (which is an identifier of the primary energy), have been studied. We characterize the single arrival time distribution by various different moments: the median Δτ 0.50 , the 1 st and the 3 rd quartiles (Δτ 0.25 and Δτ 0.75 ) which express different features of the distributions. The dependence of the measured median distributions on the distance from the shower center for a restricted Θ-range and averaged over the observed shower size spectrum is presented. The shapes can be approximated by a gamma probability distribution function. There are also displayed the mean values (Δτ 0.50 ) and the dispersion σ 0.50 of the median distributions, whose R μ -variations represent the (median) profile on the EAS muon disc. The theoretical interpretation of this kind of experimental results on the basis of Monte Carlo simulations of the EAS development is under progress. (authors)

  18. Characteristics of Ni-Cr-Fe laser clad layers on EA4T steel

    Science.gov (United States)

    Chen, Wenjing; Chen, Hui; Wang, Yongjing; Li, Congchen; Wang, Xiaoli

    2017-07-01

    The Ni-Cr-Fe metal powder was deposited on EA4T steel by laser cladding technology. The microstructure and chemical composition of the cladding layer were analyzed by optical microscopy (OM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The bonding ability between the cladding layer and the matrix was measured. The results showed that the bonding between the cladding layer and the EA4T steel was metallurgical bonding. The microstructure of cladding layer was composed of planar crystals, columnar crystals and dendrite, which consisted of Cr2Ni3, γ phase, M23C6 and Ni3B phases. When the powder feeding speed reached 4 g/min, the upper bainite occurred in the heat affected zone (HAZ). Moreover, the tensile strength of the joint increased, while the yield strength and the ductility decreased.

  19. Lead-resistant Providencia alcalifaciens strain 2EA bioprecipitates Pb+2 as lead phosphate.

    Science.gov (United States)

    Naik, M M; Khanolkar, D; Dubey, S K

    2013-02-01

    A lead-resistant bacteria isolated from soil contaminated with car battery waste were identified as Providencia alcalifaciens based on biochemical characteristics, FAME profile and 16S rRNA sequencing and designated as strain 2EA. It resists lead nitrate up to 0·0014 mol l(-1) by precipitating soluble lead as insoluble light brown solid. Scanning electron microscopy coupled with energy-dispersive X-ray spectrometric analysis (SEM-EDX) and X-ray diffraction spectroscopy (XRD) revealed extracellular light brown precipitate as lead orthophosphate mineral, that is, Pb(9) (PO(4))(6) catalysed by phosphatase enzyme. This lead-resistant bacterial strain also demonstrated tolerance to high levels of cadmium and mercury along with multiple antibiotic resistance. Providencia alcalifaciens strain 2EA could be used for bioremediation of lead-contaminated environmental sites, as it can efficiently precipitate lead as lead phosphate. © 2012 The Society for Applied Microbiology.

  20. Estimation of primary cosmic ray characteristics with the help of EAS Cherenkov light

    International Nuclear Information System (INIS)

    Aleksandrov, L.; Brankova, M.; Kirov, I.; Mishev, A.; Stamenov, J.; Ushev, S.; Mavrodiev, S.

    1999-01-01

    A new method of estimating primary cosmic ray characteristics based on the registration and analysis of EAS Cherenkov light is proposed. The nature, energy and arrival direction of primaries are obtained as a solution of a nonlinear inverse problem. The applied mathematical model is created by analyzing 'Hotovo' telescope experimental data. The behaviour of model parameters is studied using CORSIKA code for the primary energy interval 30 GeV-3 TeV. This method could be applied successfully for a different kind of detector displacements of EAS arrays. Moreover, it is shown that the shower parameter estimation could be obtained more effectively and precisely in the case of detectors displacement according to a Spiral

  1. Strength Pareto particle swarm optimization and hybrid EA-PSO for multi-objective optimization.

    Science.gov (United States)

    Elhossini, Ahmed; Areibi, Shawki; Dony, Robert

    2010-01-01

    This paper proposes an efficient particle swarm optimization (PSO) technique that can handle multi-objective optimization problems. It is based on the strength Pareto approach originally used in evolutionary algorithms (EA). The proposed modified particle swarm algorithm is used to build three hybrid EA-PSO algorithms to solve different multi-objective optimization problems. This algorithm and its hybrid forms are tested using seven benchmarks from the literature and the results are compared to the strength Pareto evolutionary algorithm (SPEA2) and a competitive multi-objective PSO using several metrics. The proposed algorithm shows a slower convergence, compared to the other algorithms, but requires less CPU time. Combining PSO and evolutionary algorithms leads to superior hybrid algorithms that outperform SPEA2, the competitive multi-objective PSO (MO-PSO), and the proposed strength Pareto PSO based on different metrics.

  2. EAS primary particle parameter estimation with the complex Pamir-XXI detector array

    Directory of Open Access Journals (Sweden)

    Galkin V.I.

    2017-01-01

    Full Text Available Some new developments in EAS methods made in the framework of the Pamir-XXI project are presented. First, primary energy and direction definition accuracies by a network of fast scintillators are considered, optimum network cell size is defined for 10 PeV showers. Second, the same accuracies for a network of fast optical (Cherenkov detectors are considered for 30 TeV–10 PeV showers. Third, the possibilities of separation of EAS initiated by protons, nitrogen and iron nuclei of 1 and 10 PeV energies using a wide-angle Cherenkov telescope are discussed. Finally, the results of the extraction of 30–50 TeV gamma showers from the proton shower background with the same telescope are presented. Presumably, our developments can help in the study of PCR mass composition and ultra high energy gamma ray astronomy in other projects.

  3. Arrival time and incidence angle distributions of extensive air showers (EAS) muons

    International Nuclear Information System (INIS)

    Brancus, I.M.; Duma, M.; Vulpescu, B.; Foeller, M.; Rebel, H.; Voelker, G.; Chilingarian, A.A.

    1995-01-01

    The arrival time distributions of the muons can be related to the longitudinal EAS development and may provide additional information about the nature of the primary. Based on EAS simulations using the Monte-Carlo code CORSIKA, the correlations between arrival time and incidence angle distributions have been investigated in a case of a set of ideal detectors (10 m x 10 m) placed at various distances from the shower core. Applying advanced statistical techniques based on Bayes decision rule and non-parametric multivariate analysing methods it turns out that the correlations of muon arrival time and incidence angle at various separating distances of about 50 m exhibit promising features for mass discrimination (author)

  4. Electron attachment rate constant measurement by photoemission electron attachment ion mobility spectrometry (PE-EA-IMS)

    International Nuclear Information System (INIS)

    Su, Desheng; Niu, Wenqi; Liu, Sheng; Shen, Chengyin; Huang, Chaoqun; Wang, Hongmei; Jiang, Haihe; Chu, Yannan

    2012-01-01

    Photoemission electron attachment ion mobility spectrometry (PE-EA-IMS), with a source of photoelectrons induced by vacuum ultraviolet radiation on a metal surface, has been developed to study electron attachment reaction at atmospheric pressure using nitrogen as the buffer gas. Based on the negative ion mobility spectra, the rate constants for electron attachment to tetrachloromethane and chloroform were measured at ambient temperature as a function of the average electron energy in the range from 0.29 to 0.96 eV. The experimental results are in good agreement with the data reported in the literature. - Highlights: ► Photoemission electron attachment ion mobility spectrometry (PE-EA-IMS) was developed to study electron attachment reaction. ► The rate constants of electron attachment to CCl 4 and CHCl 3 were determined. ► The present experimental results are in good agreement with the previously reported data.

  5. Observation of lateral substructures in EAS by measurement of the time distribution of atmospheric Cerenkov light

    International Nuclear Information System (INIS)

    Bosia, G.; Navarra, G.; Saavedra, O.

    1975-01-01

    The lateral structure of EAS is derived from the arrival time distribution of atmospheric Cerenkov light assuming a strict correlation between time structure and lateral particle distribution. Results of the Pic du Midi experiment are presented. Substructures in the time distribution of the Cerenkov light can be related to structures in the lateral density distribution of electrons. The frequency (a few %) of substructures can be explained within conventional models of high energy interactions. (orig.) [de

  6. U.H.E. γ-ray observations with the EAS-TOP array

    International Nuclear Information System (INIS)

    Aglietta, M.; Alessandro, B.; Arneodo, F.; Badino, G.; Bergamasco, L.; Castagnoli, C.; Castellina, A.; Cattadori, C.; Chiavassa, A.; Cini, G.; Piazzoli, B.D.; Fulgione, W.; Ghia, P.L.; Galeotti, P.; Mannocchi, G.; Morello, C.; Navarra, G.; Periale, L.; Riccati, L.; Saavedra, O.; Trinchero, G.C.; Vallania, P.; Vernetto, S.

    1991-01-01

    The EAS-TOP array at Gran Sasso (Italy) has been fully operating as a gamma-ray astronomy observatory since the beginning of 1989 (energy range 10 14 -10 17 eV). We present the results on search for gamma ray emission from candidate point sources in northern hemisphere obtained by data collected through 1989-1990. The UHE energy event observed from Crab Nebula on February 23rd, 1989, is also discussed

  7. D2.1 - An EA Active, Problem Based Learning Methodology - EAtrain2

    DEFF Research Database (Denmark)

    Ryberg, Thomas; Georgsen, Marianne; Buus, Lillian

    This deliverable reports on the work undertaken in work package 2 with the key objective to develop a learning methodology for web 2.0 mediated Enterprise Architecture (EA) learning building on a problem based learning (PBL) approach. The deliverable reports not only on the methodology but also...... on the activities leading to its development (literature review, workshops, etc.) and on further outcomes of this work relevant to the platform specification and pilot courses preparation....

  8. Post-Starburst Galaxies At The End of The E+A Phase

    Science.gov (United States)

    Liu, Charles; Marinelli, Mariarosa; Chang, Madeleine; Lyczko, Camilla; Vega Orozco, Cecilia; SDSS-IV Collaboration

    2018-06-01

    Post-starburst galaxies, once thought to be rare curiosities, are now recognized to represent a key phase in the galaxy evolution. The post-starburst, or E+A phase, should however not be considered as a single, short-lived phenomenon; rather, it is an extended evolutionary process that occurs a galaxy transitions from an actively star-forming system into a quiescent one. We present a study of nearby galaxies at or near the end of the E+A phase, wherein all star formation has been quenched, the fossilized stellar population of the most recent starburst is highly localized, and the remainder of the galaxy's stellar population is old and quiescent. The luminosity and stellar age distribution of these "end-phase E+As" can provide insights into the evolution of galaxies onto and within the red sequence, from active to passive systems. This work is supported by National Science Foundation grants to CUNY College of Staten Island and the American Museum of Natural History; the College of Staten Island Office of Academic Affairs; the Sherman Fairchild Science Pathways Scholars Program (SP^2) at Barnard College; and the Alfred P. Sloan Foundation.

  9. Measurement of organic carbon stable isotope composition of different soil types by EA-IRMS system

    International Nuclear Information System (INIS)

    Qi Biao; Ding Lingling; Cui Jiehua; Wang Yanhong

    2009-01-01

    Element analyzer-isotope ratio mass spectrometers (EA-IRMS) is a rapid and precise method for measuring stable carbon isotope. Pure CO 2 reference gas was calibrated via international standard-Urea, and the δ 13 C us PDB value of pure CO 2 is (-29.523 ± 0.0181)%. Stability and linearity of the EA-IRMS system, precision of δ 13 C measurement for samples were tested through experimental comparison. Moreover, determination method of organic carbon stable isotope in soil was based on the system. The EA-IRMS system had well linearity when ion intensity ranged from 1.0 to 7.0V, and it excelled the total linearity when the ion intensity was from 1.5 to 5.0V, and the accurate result of δ 13 C for sample analysis could be obtained with precision of 0.015%. If carbon content in sample is more than 5μg, the requirement for analyzing accurate result of δ 13 C could be achieved. The organic carbon stable isotope was measured in 18 different types soil samples, the average natural abundance of 13 C was 1.082%, and the organic carbon stable isotope composition was significantly different among different type soils. (authors)

  10. ACC/AHA guidelines superior to ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans

    DEFF Research Database (Denmark)

    Mortensen, Martin Bødtker; Nordestgaard, Børge G; Afzal, Shoaib

    2017-01-01

    Aim We compared the 2013 American College of Cardiology/American Heart Association (ACC/AHA) and the 2016 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on prevention of atherosclerotic cardiovascular disease (ASCVD) using different risk prediction models [US......-calibrated around decision thresholds for statin therapy. For a Class I recommendation, 42% of individuals qualified for statins using the ACC/AHA guidelines vs. 6% with the ESC/EAS guidelines. Using ACC/AHA- vs. ESC/EAS-defined statin eligibility led to a substantial gain in sensitivity (+62% for any ASCVD and+76......% for fatal ASCVD) with a smaller loss in specificity (-35% for any ASCVD and -36% for fatal ASCVD). Similar differences between the ACC/AHA and ESC/EAS guidelines were found for men and women separately, and for Class IIa recommendations. The sensitivity and specificity of a US-PCE risk of 5% were similar...

  11. 85 km Long Reach PON System Using a Reflective SOA-EA Modulator and Distributed Raman Fiber Amplification

    DEFF Research Database (Denmark)

    Tafur Monroy, Idelfonso; Öhman, Filip; Yvind, Kresten

    2006-01-01

    We report on a bidirectional 85 km long reach PON system supported by distributed fiber Raman amplification with a record 7.5 Gb/s remote carrier modulated upstream signal by employing a reflective SOA-EA monolithically integrated circuit......We report on a bidirectional 85 km long reach PON system supported by distributed fiber Raman amplification with a record 7.5 Gb/s remote carrier modulated upstream signal by employing a reflective SOA-EA monolithically integrated circuit...

  12. Determining the primary cosmic ray energy from the total flux of Cherenkov light measured at the Yakutsk EAS array

    International Nuclear Information System (INIS)

    Ivanov, A. A.; Knurenko, S. P.; Sleptsov, I. E.

    2007-01-01

    We present a method for determining the energy of the primary particle that generates an extensive air shower (EAS) of comic rays based on measuring the total flux of Cherenkov light from the shower. Applying this method to Cherenkov light measurements at the Yakutsk EAS array has allowed us to construct the cosmic ray energy spectrum in the range 10 15 - 3 x 10 19 eV

  13. Letramentos acadêmicos e multimodalidade em contexto de EaD semipresencial

    OpenAIRE

    Komesu, Fabiana

    2012-01-01

    De uma perspectiva teórica enunciativo-discursiva, este artigo tem como objetivo discutir o processo de constituição do texto em contexto digital, de maneira particularizada, por meio da problematização de modos e recursos semióticos atualizados na produção acadêmica do universitário que utiliza computador com acesso à internet no processo de Educação a Distância (EaD) semipresencial. Interessa investigar como o modelo de letramentos acadêmicos pode ser articulado ao estudo da multimodalidade...

  14. An enhanced rate of tidal disruptions in the centrally overdense E+A galaxy NGC 3156

    OpenAIRE

    Stone, Nicholas C.; van Velzen, Sjoert

    2016-01-01

    Time domain optical surveys have discovered roughly a dozen candidate stellar tidal disruption flares in the last five years, and future surveys like the {\\it Large Synoptic Survey Telescope} will likely find hundreds to thousands more. These tidal disruption events (TDEs) present an interesting puzzle: a majority of the current TDE sample is hosted by rare post-starburst galaxies, and tens of percent are hosted in even rarer E+A galaxies, which make up $\\sim 0.1\\%$ of all galaxies in the loc...

  15. ELECTRON–MUON IDENTIFICATION BY ATMOSPHERIC SHOWER AND ELECTRON BEAM IN A NEW EAS DETECTOR CONCEPT

    Energy Technology Data Exchange (ETDEWEB)

    Iori, M. [“Sapienza” Univeristy of Rome, Piazzale A. Moro 5, Rome I-00185 (Italy); Denizli, H.; Yilmaz, A. [Abant Izzet Baysal University, Bolu 14280 (Turkey); Ferrarotto, F. [Istituto Nazionale di Fisica Nucleare (INFN)—Sezione di Roma, Rome I-00185 (Italy); Russ, J., E-mail: Maurizio.Iori@roma1.infn.it [Carnegie-Mellon University, Pittsburgh, PA 15213 (United States)

    2015-03-10

    We present results demonstrating the time resolution and μ/e separation capabilities of a new concept  for an EAS detector capable of measuring cosmic rays arriving with large zenith angles. This kind of detector has been designed to be part of a large area (several square kilometer) surface array designed to measure ultra high energy (10–200 PeV) τ neutrinos using the Earth-skimming technique. A criterion to identify electron-gammas is also shown and the particle identification capability is tested by measurements in coincidence with the KASKADE-GRANDE experiment in Karlsruhe, Germany.

  16. Electron-Muon Identification by Atmospheric Shower and Electron Beam in a New EAS Detector Concept

    Science.gov (United States)

    Iori, M.; Denizli, H.; Yilmaz, A.; Ferrarotto, F.; Russ, J.

    2015-03-01

    We present results demonstrating the time resolution and μ/e separation capabilities of a new concept for an EAS detector capable of measuring cosmic rays arriving with large zenith angles. This kind of detector has been designed to be part of a large area (several square kilometer) surface array designed to measure ultra high energy (10-200 PeV) τ neutrinos using the Earth-skimming technique. A criterion to identify electron-gammas is also shown and the particle identification capability is tested by measurements in coincidence with the KASKADE-GRANDE experiment in Karlsruhe, Germany.

  17. Exotic geophysical phenomena observed in an environmental neutron flux study using EAS PRISMA detectors

    Directory of Open Access Journals (Sweden)

    Alekseenko Victor

    2017-01-01

    Full Text Available Some exotic geophysical events are observed by a global net of electron-neutron detectors (en-detectors developed in the framework of the PRISMA EAS project. Our en-detectors running both on the Earth's surface and underground are continuously measuring the environmental thermal neutron flux. Thermal neutrons are in equilibrium with media and are therefore sensitive to many geophysical phenomena, which are exotic for people studying ultra high-energy cosmic rays or carrying out low background experiments deep underground.

  18. MMAS vs. Population-based EA on a family of dynamic fitness functions

    DEFF Research Database (Denmark)

    Lissovoi, Andrei; Witt, Carsten

    2014-01-01

    We study the behavior of a population-based EA and the Max-Min Ant System (MMAS) on a family of deterministically-changing fitness functions, where, in order to find the global optimum, the algorithms have to find specific local optima within each of a series of phases. In particular, we prove...... a Maze function extended over a finite alphabet of μ symbols, whereas population size μ-1 is not sufficient. Furthermore, we show that MMAS does not require additional modifications to track the optimum of the finite-alphabet Maze functions, and, using a novel drift statement to simplify the analysis...

  19. MMAS Versus Population-Based EA on a Family of Dynamic Fitness Functions

    DEFF Research Database (Denmark)

    Lissovoi, Andrei; Witt, Carsten

    2015-01-01

    We study the behavior of a population-based EA and the Max–Min Ant System (MMAS) on a family of deterministically-changing fitness functions, where, in order to find the global optimum, the algorithms have to find specific local optima within each of a series of phases. In particular, we prove...... function extended over a finite alphabet of μ symbols, whereas population size μ−1 is not sufficient. Furthermore, we show that MMAS does not require additional modifications to track the optimum of the finite-alphabet Maze functions, and, using a novel drift statement to simplify the analysis, reduce...

  20. Effect of medium components and culture conditions in Bacillus subtilis EA-CB0575 spore production.

    Science.gov (United States)

    Posada-Uribe, Luisa F; Romero-Tabarez, Magally; Villegas-Escobar, Valeska

    2015-10-01

    Bacillus subtilis spores have important biotechnological applications; however, achieving both, high spore cell densities and sporulation efficiencies in fermentation, is poorly reported. In this study, medium components and culture conditions were optimized with different statistical methods to increase spore production of the plant growth promoting rhizobacteria B. subtilis EA-CB0575. Key medium components were determined with Plackett-Burman (PB) design, and the optimum concentration levels of two components (glucose, MgSO4·7H2O) were optimized with a full factorial and central composite design, achieving 1.37 × 10(9) CFU/mL of spore cell density and 93.5 % of sporulation efficiency in shake flask. The optimized medium was used to determine the effect of culture conditions on spore production at bioreactor level, finding that maintaining pH control did not affect significantly spore production, while the interaction of agitation and aeration rates had a significant effect on spore cell density. The overall optimization generated a 17.2-fold increase in spore cell density (8.78 × 10(9) CFU/mL) and 1.9-fold increase in sporulation efficiency (94.2 %) compared to that of PB design. These results indicate the potential of B. subtilis EA-CB0575 to produce both, high spore cell densities and sporulation efficiencies, with very low nutrient requirements and short incubation period which can represent savings of process production.

  1. Searching saturation effects in inclusive and exclusive eA processes

    International Nuclear Information System (INIS)

    Goncalves, V.P.

    2016-01-01

    In this contribution we have discussed the search of saturation effects in inclusive and exclusive eA processes. In particular, we present a comparison between the linear and non-linear predictions for the nuclear structure functions as well as for the Deep Virtual Compton Scattering (DVCS) and vector meson production in future eA colliders. These results demonstrated that although the inclusive observables are sensitive to saturation effects, it is not yet possible to draw any firm conclusion concerning the QCD dynamics from inclusive quantities due to the large uncertainty present in the collinear predictions. In contrast, exclusive processes are promising observables to search saturation effects, due to the quadratic dependence on the forward scattering amplitude. In particular, the analysis of the nuclear DVCS and vector meson production demonstrated that the energy dependence of the differential cross sections are strongly modified with the increasing of the atomic mass number and that coherent cross section dominates at small t and the incoherent one at large t. Moreover, the number of dips at small t increases with the atomic number, with the position of the dips being almost independent of the model used to treat the dipole - proton interaction

  2. Hydroelectric project EA's [environmental assessments]: The Magpie development in northern Ontario

    International Nuclear Information System (INIS)

    Ashwood, K.

    1992-01-01

    Great Lakes Power recently constructed a hydroelectric plant on the Magpie River near Wawa, Ontario. The project involved three main elements: construction of a 33 m high dam, a 15.5 MW power station, and a spillway at Steephill Falls; construction of a 3.5 m high overflow weir just above the crest of scenic Magpie Falls, creating a head pond to supply a 15 MW power plant; and construction of a weir and 15 MW power plant at Mission Falls. Although this was a private development and therefore not automatically subject to Ontario's Environmental Assessment Act, Great Lakes Power decided to conform with the act's requirements and undertook a comprehensive environmental assessment (EA). Environmental issues were focused on changes in hydrology and water quality, impacts on fisheries and natural resources, slope stability and erosion, socioeconomic impacts, impacts on heritage resources, and impacts on tourism and recreation. The project was approved subject to conditions which included implementation of mitigation and monitoring requirements outlined in the EA document. Environmental specialists worked closely with the engineers at the detailed design stage of the project, resulting in modifications to the preliminary design to minimize environmental impacts

  3. Differentiation of partial acylglycerols derived from different animal fats by EA-IRMS and GCMS techniques

    Energy Technology Data Exchange (ETDEWEB)

    Nina Naquiah, A.N.; Marikkar, J.M.N.; Shuhaimi, M.

    2016-07-01

    A study was carried out to compare partial acylglycerols of lard with those of chicken fat, beef fat and mutton fat using Gas Chromatography Mass Spectrometry (GC-MS) and Elemental Analysis–Isotope Ratio Mass Spectrometry (EA-IRMS). Mono- (MAG) and di-(DAG) acylglycerols of animal fats were prepared according to a chemical glycerolysis method and isolated using column chromatography. The fatty acid composition and δ13C carbon isotope ratio of MAG and DAG derived from individual animal fat were determined separately to establish their identity characteristics. The results showed that the δ13C values of MAG and DAG of lard were significantly different from those of MAG and DAG derived from chicken fat, beef fat and mutton fat. According to the loading plots based on a principle component analysis (PCA), fatty acids namely stearic, oleic and linoleic were the most discriminating parameters to distinctly identify MAG and DAG derived from different animal fats. This demonstrated that the EA-IRMS and the PCA of fatty acid data have considerable potential for discriminating MAG and DAG derived from lard from other animal fats for Halal authentication purposes. (Author)

  4. Membrane topology and identification of key residues of EaDAcT, a plant MBOAT with unusual substrate specificity.

    Science.gov (United States)

    Tran, Tam N T; Shelton, Jennifer; Brown, Susan; Durrett, Timothy P

    2017-10-01

    Euonymus alatus diacylglycerol acetyltransferase (EaDAcT) catalyzes the transfer of an acetyl group from acetyl-CoA to the sn-3 position of diacylglycerol to form 3-acetyl-1,2-diacyl-sn-glycerol (acetyl-TAG). EaDAcT belongs to a small, plant-specific subfamily of the membrane bound O-acyltransferases (MBOAT) that acylate different lipid substrates. Sucrose gradient density centrifugation revealed that EaDAcT colocalizes to the same fractions as an endoplasmic reticulum (ER)-specific marker. By mapping the membrane topology of EaDAcT, we obtained an experimentally determined topology model for a plant MBOAT. The EaDAcT model contains four transmembrane domains (TMDs), with both the N- and C-termini orientated toward the lumen of the ER. In addition, there is a large cytoplasmic loop between the first and second TMDs, with the MBOAT signature region of the protein embedded in the third TMD close to the interface between the membrane and the cytoplasm. During topology mapping, we discovered two cysteine residues (C187 and C293) located on opposite sides of the membrane that are important for enzyme activity. In order to identify additional amino acid residues important for acetyltransferase activity, we isolated and characterized acetyltransferases from other acetyl-TAG-producing plants. Among them, the acetyltransferase from Euonymus fortunei possessed the highest activity in vivo and in vitro. Mutagenesis of conserved amino acids revealed that S253, H257, D258 and V263 are essential for EaDAcT activity. Alteration of residues unique to the acetyltransferases did not alter the unique acyl donor specificity of EaDAcT, suggesting that multiple amino acids are important for substrate recognition. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

  5. Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018

    Directory of Open Access Journals (Sweden)

    Wang Shengyue

    2011-02-01

    Full Text Available Abstract Background Clostridium acetobutylicum, a gram-positive and spore-forming anaerobe, is a major strain for the fermentative production of acetone, butanol and ethanol. But a previously isolated hyper-butanol producing strain C. acetobutylicum EA 2018 does not produce spores and has greater capability of solvent production, especially for butanol, than the type strain C. acetobutylicum ATCC 824. Results Complete genome of C. acetobutylicum EA 2018 was sequenced using Roche 454 pyrosequencing. Genomic comparison with ATCC 824 identified many variations which may contribute to the hyper-butanol producing characteristics in the EA 2018 strain, including a total of 46 deletion sites and 26 insertion sites. In addition, transcriptomic profiling of gene expression in EA 2018 relative to that of ATCC824 revealed expression-level changes of several key genes related to solvent formation. For example, spo0A and adhEII have higher expression level, and most of the acid formation related genes have lower expression level in EA 2018. Interestingly, the results also showed that the variation in CEA_G2622 (CAC2613 in ATCC 824, a putative transcriptional regulator involved in xylose utilization, might accelerate utilization of substrate xylose. Conclusions Comparative analysis of C. acetobutylicum hyper-butanol producing strain EA 2018 and type strain ATCC 824 at both genomic and transcriptomic levels, for the first time, provides molecular-level understanding of non-sporulation, higher solvent production and enhanced xylose utilization in the mutant EA 2018. The information could be valuable for further genetic modification of C. acetobutylicum for more effective butanol production.

  6. WES: A well test analysis expert system

    International Nuclear Information System (INIS)

    Mensch, A.

    1988-06-01

    This report describes part of the development of an expert system in the domain of well-test analysis. This work has been done during my final internship, completed at the Lawrence Berkeley Laboratory. The report is divided in three parts: the first one gives a description of the state of the project at the time I first began to work on it, and raises some problems that have to be solved. The second section shows the results that have been reached, and the last one draws conclusions from these results and proposes extensions that would be useful in the future

  7. Search for Anti-EA(D Antibodies in Subjects with an “Isolated VCA IgG” Pattern

    Directory of Open Access Journals (Sweden)

    Massimo De Paschale

    2010-01-01

    Full Text Available The presence of an “isolated viral capsid antigen (VCA IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. However, one alternative is to use an enzyme-linked immunosorbent assay (ELISA to detect anti-early antigen (EA antibodies, which can be found in about 85% of subjects with acute Epstein-Barr virus (EBV infections. The purpose of this work was to search for anti-EA(D antibodies in 130 samples with an isolated VCA IgG pattern at ELISA screening and classified as being indicative of past (102 cases or acute (28 cases infection on the basis of the immunoblotting results. Thirty-seven samples (28.5% were positive for anti-EA(D, of which 25 (89.3% had been classified by immunoblotting as indicating acute and 12 (11.8% past EBV infection. This difference was statistically significant (<.01. The results of our search for anti-EA(D antibodies correctly identified nearly 90% of acute (presence or past EBV infections (absence. When other tests are not available, the search for anti-EA antibodies may therefore be helpful in diagnosing patients with an isolated VCA IgG pattern at screening tests.

  8. Preequilibrium light particle emission in heavy ion collisions for E/A between 10 and 20 MeV/A

    International Nuclear Information System (INIS)

    Kailas, S.

    1989-01-01

    It is known that when two heavy ions collide, while the interaction process is dominated by nucleus-nucleus mean field effects at lower energies (E/A < 10Me V), the nucleon-nucleon collision aspects dominate at higher energies (E/A <100 MeV) . In the intermediate E/A region, both the above mentioned effects are important t o varying degrees. Many experiments have shown that when the incident energy excee ds 10 MeV/A, the complete fusion (CF) of target and projectile gives way to an inco mplete fusion (ICF) mechanism associated with preequilibrium light particle (PELP) emmi sion. This phenomenon becomes increasingly important as E increases and at E/A < 20 Me V, the cross section for PELP emission becomes comparable to the reaction cross section . Considerable progress has been made in the last decade towards understanding of ICF and PELP. In the present work, the review of this field is mainly restricted to E/A values lying between 10 and 20 MeV/A. (author). 27 refs., 5 figs

  9. Oxygen isotope analysis of phosphate: improved precision using TC/EA CF-IRMS.

    Science.gov (United States)

    LaPorte, D F; Holmden, C; Patterson, W P; Prokopiuk, T; Eglington, B M

    2009-06-01

    Oxygen isotope values of biogenic apatite have long demonstrated considerable promise for paleothermometry potential because of the abundance of material in the fossil record and greater resistance of apatite to diagenesis compared to carbonate. Unfortunately, this promise has not been fully realized because of relatively poor precision of isotopic measurements, and exceedingly small size of some substrates for analysis. Building on previous work, we demonstrate that it is possible to improve precision of delta18O(PO4) measurements using a 'reverse-plumbed' thermal conversion elemental analyzer (TC/EA) coupled to a continuous flow isotope ratio mass spectrometer (CF-IRMS) via a helium stream [Correction made here after initial online publication]. This modification to the flow of helium through the TC/EA, and careful location of the packing of glassy carbon fragments relative to the hot spot in the reactor, leads to narrower, more symmetrically distributed CO elution peaks with diminished tailing. In addition, we describe our apatite purification chemistry that uses nitric acid and cation exchange resin. Purification chemistry is optimized for processing small samples, minimizing isotopic fractionation of PO4(-3) and permitting Ca, Sr and Nd to be eluted and purified further for the measurement of delta44Ca and 87Sr/86Sr in modern biogenic apatite and 143Nd/144Nd in fossil apatite. Our methodology yields an external precision of +/- 0.15 per thousand (1sigma) for delta18O(PO4). The uncertainty is related to the preparation of the Ag3PO4 salt, conversion to CO gas in a reversed-plumbed TC/EA, analysis of oxygen isotopes using a CF-IRMS, and uncertainty in constructing calibration lines that convert raw delta18O data to the VSMOW scale. Matrix matching of samples and standards for the purpose of calibration to the VSMOW scale was determined to be unnecessary. Our method requires only slightly modified equipment that is widely available. This fact, and the

  10. Exogenous vs Endogenous Growth in the EU’s EaP and Central Asian Countries

    Directory of Open Access Journals (Sweden)

    Sharipov Ilkhom

    2016-12-01

    Full Text Available The main purpose of this paper is to determine and analyse the factors that affected economic growth in the EU’s Eastern Partnership and Central Asian countries in the 2000-2015 period. Economic growth is one of the main targets of economic policy of any country and influenced by various determinants. Of particular interest is the endogenous and exogenous nature of these factors. Having classified these factors into exogenous and endogenous ones, we examined and determined the significance and robustness of various factors influencing the economic growth in these countries, like investment, human capital, research and development, economic policies and macroeconomic conditions, openness to trade, geography, political factors and others. Correlation and factor analysis showed significance and strong association of GDP per capita with physical, human capital, and R&D in EaP countries and with natural resources and active population share in Central Asian countries.

  11. WH-EA: An Evolutionary Algorithm for Wiener-Hammerstein System Identification

    Directory of Open Access Journals (Sweden)

    J. Zambrano

    2018-01-01

    Full Text Available Current methods to identify Wiener-Hammerstein systems using Best Linear Approximation (BLA involve at least two steps. First, BLA is divided into obtaining front and back linear dynamics of the Wiener-Hammerstein model. Second, a refitting procedure of all parameters is carried out to reduce modelling errors. In this paper, a novel approach to identify Wiener-Hammerstein systems in a single step is proposed. This approach is based on a customized evolutionary algorithm (WH-EA able to look for the best BLA split, capturing at the same time the process static nonlinearity with high precision. Furthermore, to correct possible errors in BLA estimation, the locations of poles and zeros are subtly modified within an adequate search space to allow a fine-tuning of the model. The performance of the proposed approach is analysed by using a demonstration example and a nonlinear system identification benchmark.

  12. Population Size vs. Mutation Strength for the (1+λ) EA on OneMax

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2015-01-01

    The (1+1) EA with mutation probability c/n, where c>0 is an arbitrary constant, is studied for the classical OneMax function. Its expected optimization time is analyzed exactly (up to lower order terms) as a function of c and λ. It turns out that 1/n is the only optimal mutation probability if λ......=o(ln n ln ln n/ln ln ln n), which is the cut-off point for linear mnspeed-up. However, if λ is above this cut-off point then the standard mutation probability 1/n is no longer the only optimal choice. Instead, the expected number of generations is (up to lower order terms) independent of c...

  13. Multigap resistive plate chambers for EAS study in the EEE Project

    CERN Document Server

    An, S; Badalà, A; Zichichi, A

    2007-01-01

    The EEE (Extreme Energy Events) Project, conceived by its leader Antonino Zichichi, is an experiment to study very high-energetic air showers (EAS) through the detection of the shower's muon component using a network of tracking detectors, installed in Italian high schools. The single tracking telescope is composed of three large area () Multi-gap Resistive Plate Chambers (MRPCs). The data collected by the telescopes will be used for studies of air showers and also for the search of time correlations between sites which are far apart. The first telescope, recently installed in the Liceo B. Touschek in Grottaferrata (Rome), is successfully running, and other telescopes are going to be installed in a short time in other towns, opening up the way for the first search of long-distance coincidences over a total area of .

  14. Differentiation of partial acylglycerols derived from different animal fats by EA-IRMS and GCMS techniques

    Directory of Open Access Journals (Sweden)

    Nina Naquiah, A. N.

    2016-06-01

    Full Text Available A study was carried out to compare partial acylglycerols of lard with those of chicken fat, beef fat and mutton fat using Gas Chromatography Mass Spectrometry (GC-MS and Elemental Analysis–Isotope Ratio Mass Spectrometry (EA-IRMS. Mono- (MAG and di-(DAG acylglycerols of animal fats were prepared according to a chemical glycerolysis method and isolated using column chromatography. The fatty acid composition and δ13C carbon isotope ratio of MAG and DAG derived from individual animal fat were determined separately to establish their identity characteristics. The results showed that the δ13C values of MAG and DAG of lard were significantly different from those of MAG and DAG derived from chicken fat, beef fat and mutton fat. According to the loading plots based on a principle component analysis (PCA, fatty acids namely stearic, oleic and linoleic were the most discriminating parameters to distinctly identify MAG and DAG derived from different animal fats. This demonstrated that the EA-IRMS and the PCA of fatty acid data have considerable potential for discriminating MAG and DAG derived from lard from other animal fats for Halal authentication purposes.Se realizó un estudio para comparar acilgliceroles parciales de la manteca de cerdo con las de grasa de pollo, grasa de vacuno y grasa de cordero utilizando cromatografía de gases-espectrometría de masas (GC-MS y análisis elemental de Isótopos-Espectrometría de Masas (EA-IRMS. Los mono- (MAG y di- (DAG acilgliceroles de grasas animales se prepararon mediante un método de glicerolisis química y se aislaron mediante cromatografía en columna. La composición de ácidos grasos y la relación isotópica de carbono δ13C de los MAG y DAG de las grasas de animales se determinan por separado para establecer sus características de identidad. Los resultados mostraron que los valores de δ13C de MAG y DAG de la manteca de cerdo fue significativamente diferente de los de MAG y DAG derivados de grasa

  15. Stable Carbon Isotope Ratio (δ13C Measurement of Graphite Using EA-IRMS System

    Directory of Open Access Journals (Sweden)

    Andrius Garbaras

    2015-06-01

    Full Text Available δ13C values in non-irradiated natural graphite were measured. The measurements were carried out using an elemental analyzer combined with stable isotope ratio mass spectrometer (EA-IRMS. The samples were prepared with ground and non-ground graphite, the part of which was mixed with Mg (ClO42. The best combustion of graphite in the oxidation furnace of the elemental analyzer was achieved when the amount of pulverized graphite ranged from 200 to 490 µg and the mass ratio C:Mg(ClO42 was approximately 1:10. The method for the graphite burning avoiding the isotope fractionation is proposed.DOI: http://dx.doi.org/10.5755/j01.ms.21.2.6873

  16. A Study of E+A Galaxies Through SDSS-MaNGA Integral Field Spectroscopy

    Science.gov (United States)

    Wally, Muhammad; Weaver, Olivia A.; Anderson, Miguel Ricardo; Liu, Allen; Falcone, Julia; Wallack, Nicole Lisa; James, Olivia; Liu, Charles

    2017-01-01

    We outline the selection process and analysis of sixteen E+A galaxies observed by the Mapping Nearby Galaxies at the Apache Point Observatory (MaNGA) survey as a part of the fourth generation of the Sloan Digital Sky Survey (SDSS-IV). We present their Integral field spectroscopy and analyze their spatial distribution of stellar ages, metallicities and other stellar population properties. We can potentially study the variation in these properties as a function of redshift. This work was supported by the Alfred P. Sloan Foundation via the SDSS-IV Faculty and Student Team (FAST) initiative, ARC Agreement #SSP483 to the CUNY College of Staten Island. This work was also supported by grants to The American Museum of Natural History, and the CUNY College of Staten Island through The National Science Foundation.

  17. Sailuotong Prevents Hydrogen Peroxide (H2O2-Induced Injury in EA.hy926 Cells

    Directory of Open Access Journals (Sweden)

    Sai Wang Seto

    2017-01-01

    Full Text Available Sailuotong (SLT is a standardised three-herb formulation consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus designed for the management of vascular dementia. While the latest clinical trials have demonstrated beneficial effects of SLT in vascular dementia, the underlying cellular mechanisms have not been fully explored. The aim of this study was to assess the ability and mechanisms of SLT to act against hydrogen peroxide (H2O2-induced oxidative damage in cultured human vascular endothelial cells (EAhy926. SLT (1–50 µg/mL significantly suppressed the H2O2-induced cell death and abolished the H2O2-induced reactive oxygen species (ROS generation in a concentration-dependent manner. Similarly, H2O2 (0.5 mM; 24 h caused a ~2-fold increase in lactate dehydrogenase (LDH release from the EA.hy926 cells which were significantly suppressed by SLT (1–50 µg/mL in a concentration-dependent manner. Incubation of SLT (50 µg/mL increased superoxide dismutase (SOD activity and suppressed the H2O2-enhanced Bax/Bcl-2 ratio and cleaved caspase-3 expression. In conclusion, our results suggest that SLT protects EA.hy916 cells against H2O2-mediated injury via direct reduction of intracellular ROS generation and an increase in SOD activity. These protective effects are closely associated with the inhibition of the apoptotic death cascade via the suppression of caspase-3 activation and reduction of Bax/Bcl-2 ratio, thereby indicating a potential mechanism of action for the clinical effects observed.

  18. After the Fall: The Dust and Gas in E+A Post-starburst Galaxies

    Science.gov (United States)

    Smercina, A.; Smith, J. D. T.; Dale, D. A.; French, K. D.; Croxall, K. V.; Zhukovska, S.; Togi, A.; Bell, E. F.; Crocker, A. F.; Draine, B. T.; Jarrett, T. H.; Tremonti, C.; Yang, Yujin; Zabludoff, A. I.

    2018-03-01

    The traditional picture of post-starburst galaxies as dust- and gas-poor merger remnants, rapidly transitioning to quiescence, has been recently challenged. Unexpected detections of a significant interstellar medium (ISM) in many post-starburst galaxies raise important questions. Are they truly quiescent, and if so, what mechanisms inhibit further star formation? What processes dominate their ISM energetics? We present an infrared spectroscopic and photometric survey of 33 E+A post-starbursts selected by the Sloan Digital Sky Survey, aimed at resolving these questions. We find compact, warm dust reservoirs with high PAH abundances and total gas and dust masses significantly higher than expected from stellar recycling alone. Both polycyclic aromatic hydrocarbon (PAH)/total infrared (TIR) and dust-to-burst stellar mass ratios are seen to decrease with post-burst age, indicative of the accumulating effects of dust destruction and an incipient transition to hot, early-type ISM properties. Their infrared spectral properties are unique, with dominant PAH emission, very weak nebular lines, unusually strong H2 rotational emission, and deep [C II] deficits. There is substantial scatter among star formation rate (SFR) indicators, and both PAH and TIR luminosities provide overestimates. Even as potential upper limits, all tracers show that the SFR has typically experienced a decline of more than two orders of magnitude since the starburst and that the SFR is considerably lower than expected given both their stellar masses and molecular gas densities. These results paint a coherent picture of systems in which star formation was, indeed, rapidly truncated, but in which the ISM was not completely expelled, and is instead supported against collapse by latent or continued injection of turbulent or mechanical heating. The resulting aging burst populations provide a “high-soft” radiation field that seemingly dominates the E+A galaxies’ unusual ISM energetics.

  19. Evaluation of RSDL, M291 SDK, 0.5% Bleach, 1% Soapy Water and SERPACWA. Part 12: Challenge with EA1212 (GF, cyclosarin)

    Science.gov (United States)

    2016-01-01

    products in the haired guinea pig model following exposure to GF (EA1212). 15. SUBJECT TERMS decontamination, delayed decontamination, Reactive Skin...the four listed decontamination products in the haired guinea pig model following exposure to GF (EA1212). In all experiments, guinea pigs were close...the four listed decontamination products and SERPACWA in the haired guinea pig model following exposure to GF [cyclosarin, EA1212, Cyclohexyl

  20. Investigation of relative arrival time distributions of EAS electron and muon component with the KASCADE central detector

    International Nuclear Information System (INIS)

    Hafemann, W.; Haeusler, R.; Rebel, H.; Mathes, H.J.

    2000-01-01

    The central detector of the KASCADE experiment is equipped with two layers of scintillation detectors with different area coverage. The scintillators of both detector systems have a good timing resolution of about 1.6 ns. With these two arrangements we performed extensive measurements of the arrival time differences at different energy thresholds of the electron and the muon component of EAS. The observed time structure of the shower profile is classified according to different EAS parameters. We furthermore present an analysis and comparism based on detailed MC simulations of the shower development. This comparism shows good agreement between experimental data and the expected behaviour of the different time distributions. (orig.)

  1. Overcoming hybridization barriers by the secretion of the maize pollen tube attractant ZmEA1 from Arabidopsis ovules.

    Science.gov (United States)

    Márton, Mihaela L; Fastner, Astrid; Uebler, Susanne; Dresselhaus, Thomas

    2012-07-10

    A major goal of plant reproduction research is to understand and overcome hybridization barriers so that the gene pool of crop plants can be increased and improved upon. After successful pollen germination on a receptive stigma, the nonmotile sperm cells of flowering plants are transported via the pollen tube (PT) to the egg apparatus for the achievement of double fertilization. The PT path is controlled by various hybridization mechanisms probably involving a larger number of species-specific molecular interactions. The egg-apparatus-secreted polymorphic peptides ZmEA1 in maize and LURE1 and LURE2 in Torenia fournieri as well as TcCRP1 in T. concolor were shown to be required for micropylar PT guidance, the last step of the PT journey. We report here that ZmEA1 attracts maize PTs in vitro and arrests their growth at higher concentrations. Furthermore, it binds to the subapical region of maize PT tips in a species-preferential manner. To overcome hybridization barriers at the level of gametophytic PT guidance, we expressed ZmEA1 in Arabidopsis synergid cells. Secreted ZmEA1 enabled Arabidopsis ovules to guide maize PT in vitro in a species-preferential manner to the micropylar opening of the ovule. These results demonstrate that the egg-apparatus-controlled reproductive-isolation barrier of PT guidance can be overcome even between unrelated plant families. Copyright © 2012 Elsevier Ltd. All rights reserved.

  2. 77 FR 33972 - Channel Spacing and Bandwidth Limitations for Certain Economic Area (EA)-based 800 MHz...

    Science.gov (United States)

    2012-06-08

    ..., 445 12th Street SW., Washington, DC 20554. The complete text may be purchased from the Commission's... regulatory parity between commercial wireless licensees, to consumers' benefit. Under this rule change, EA... begin, the specific locations of antenna sites, and effective radiated power (ERP) for each antenna site...

  3. 33 CFR 230.7 - Actions normally requiring an Environmental Assessment (EA) but not necessarily an EIS.

    Science.gov (United States)

    2010-07-01

    .... (d) Construction and Operations and Maintenance. Changes in environmental impacts which were not considered in the project EIS or EA. Examples are changes in pool level operations, use of new disposal areas, location of bank protection works, etc. (e) Real Estate Management and Disposal Actions. (1) Disposal of a...

  4. 85 km long reach PON system using a reflective SOA-EA modulator and distributed Raman fiber amplification

    NARCIS (Netherlands)

    Tafur Monroy, I.; Öhman, F.; Yvind, K.; Kjaer, R.; Peucheret, C.; Koonen, A.M.J.; Jeppesen, P.

    2006-01-01

    We report on a bidirectional 85 km long reach PON system supported by distributed fiber Raman amplification with a record 7.5 Gb/s remote carrier modulated upstream signal by employing a reflective SOA-EA monolithically integrated circuit.

  5. 47 CFR 90.699 - Transition of the upper 200 channels in the 800 MHz band to EA licensing.

    Science.gov (United States)

    2010-10-01

    ... are defined as the actual costs associated with providing a replacement system, such as equipment and... activities necessary for implementing the replacement facilities, including engineering and cost analysis of... equipment and analog replacement parts can be difficult to find. An EA licensee's obligation to pay...

  6. Projectile-like fragments from 129Xe+natCu reactions at E/A = 40 MeV

    International Nuclear Information System (INIS)

    Russ, D.E.; Mignerey, A.C.; Garcia-Solis, E.J.

    1996-01-01

    The bombarding of heavy nuclei with energetic heavy projectiles has been one of the most important experimental tools for nuclear science. At low beam energies, (E/A) beam 100 MeV, these mean field effects are less important and nucleon-nucleon interactions dominate. Within the intermediate energy region, the situation is less clear because of both the mean field and nucleon-nucleon effects contribute. There is no consensus on the theoretical treatment of nuclear reaction in the intermediate energy regime and statistical, dynamical, and hybrid models have been used with limited success. Previous studies of 136 Xe + 209 Bi at E/A = 28 MeV carried out at Michigan State University (MSU) have been well described by a damped reaction mechanism. On the other hand, 129 Xe + nat Cu at E/A = 50 MeV also at MSU has been compared with a hybrid model with reasonable success. In order to see a transition from a damped reaction mechanism to more fragmentation-like processes, an experiment was carried out at MSU using 129 Xe beams at E/A = 30, 40, 50, and 60 MeV. The targets were Cu, Sc, and Au. The current study only looks at the projectile-like fragments (PLF) detected in the Maryland Forward Array (MFA)

  7. Dynamical aspects of violent collisions in Ar + Ag reactions at E/A = 27 MeV

    International Nuclear Information System (INIS)

    Rivet, M.F.; Borderie, B.; Jouan, D.; Remaud, B.

    1988-01-01

    Intermediate-mass fragment studies were found to give an overview of the mechanisms involved in violent collisions between Ar and Ag at E/A = 27 MeV. A comparison is made with semi-classical calculations (Landau-Vlasov) which reproduce experimental observations well and sustain the persistence of dissipative processes at high incident relative velocity (∼ 0.2c)

  8. Spectral Analysis, Synthesis, & Energy Distributions of Nearby E+A Galaxies Using SDSS-IV MaNGA

    Science.gov (United States)

    Weaver, Olivia A.; Anderson, Miguel Ricardo; Wally, Muhammad; James, Olivia; Falcone, Julia; Liu, Allen; Wallack, Nicole; Liu, Charles; SDSS Collaboration

    2017-01-01

    Utilizing data from the Mapping Nearby Galaxies at APO (MaNGA) Survey (MaNGA Product Launch-4, or MPL-4), of the latest generation of the Sloan Digital Sky Survey (SDSS-IV), we identified nine post-starburst (E+A) systems that lie within the Green Valley transition zone. We identify the E+A galaxies by their SDSS single fiber spectrum and u-r color, then confirmed their classification as post-starburst by coding/plotting methods and spectral synthesis codes (FIREFLY and PIPE3D), as well as with their Spectral Energy Distributions (SEDs) from 0.15 µm to 22 µm, using GALEX, SDSS, 2MASS, and WISE data. We produced maps of gaussian-fitted fluxes, equivalent widths, stellar velocities, metallicities and age. We also produced spectral line ratio diagrams to classify regions of stellar populations of the galaxies. We found that our sample of E+As retain their post-starburst properties across the entire galaxy, not just at their center. We detected matching a trend line in the ultraviolet and optical bands, consistent with the expected SEDs for an E+A galaxy, and also through the J, H and Ks bands, except for one object. We classified one of the nine galaxies as a luminous infrared galaxy, unusual for a post-starburst object. Our group seeks to further study stellar population properties, spectral energy distributions and quenching properties in E+A galaxies, and investigate their role in galaxy evolution as a whole. This work was supported by the Alfred P. Sloan Foundation via the SDSS-IV Faculty and Student Team (FAST) initiative, ARC Agreement #SSP483 to the CUNY College of Staten Island. This work was also supported by grants to The American Museum of Natural History, and the CUNY College of Staten Island through from National Science Foundation.

  9. Surface-water interface induces conformational changes critical for protein adsorption: Implications for monolayer formation of EAS hydrophobin

    Directory of Open Access Journals (Sweden)

    Kamron eLey

    2015-11-01

    Full Text Available The class I hydrophobin EAS is part of a family of small, amphiphilic fungal proteins best known for their ability to self-assemble into stable monolayers that modify the hydrophobicity of a surface to facilitate further microbial growth. These proteins have attracted increasing attention for industrial and biomedical applications, with the aim of designing surfaces that have the potential to maintain their clean state by resisting non-specific protein binding. To gain a better understanding of this process, we have employed all-atom molecular dynamics to study initial stages of the spontaneous adsorption of monomeric EAS hydrophobin on fully hydroxylated silica, a commonly used industrial and biomedical substrate. Particular interest has been paid to the Cys3-Cys4 loop, which has been shown to exhibit disruptive behavior in solution, and the Cys7-Cys8 loop, which is believed to be involved in the aggregation of EAS hydrophobin at interfaces. Specific and water mediated interactions with the surface were also analyzed. We have identified two possible binding motifs, one which allows unfolding of the Cys7-Cys8 loop due to the surfactant-like behavior of the Cys3-Cys4 loop, and another which has limited unfolding due to the Cys3-Cys4 loop remaining disordered in solution. We have also identified intermittent interactions with water which mediate the protein adsorption to the surface, as well as longer lasting interactions which control the diffusion of water around the adsorption site. These results have shown that EAS behaves in a similar way at the air-water and surface-water interfaces, and have also highlighted the need for hydrophilic ligand functionalization of the silica surface in order to prevent the adsorption of EAS hydrophobin.

  10. A Multi-Level Investigation into the Antecedents of Enterprise Architecture (EA) Assimilation in the U.S. Federal Government: A Longitudinal Mixed Methods Research Study

    Science.gov (United States)

    Makiya, George K.

    2012-01-01

    This dissertation reports on a multi-dimensional longitudinal investigation of the factors that influence Enterprise Architecture (EA) diffusion and assimilation within the U.S. federal government. The study uses publicly available datasets of 123 U.S. federal departments and agencies, as well as interview data among CIOs and EA managers within…

  11. Photometric solution and frequency analysis of the oEA system EW Boo

    International Nuclear Information System (INIS)

    Zhang, X. B.; Wang, K.; Luo, Y. P.

    2015-01-01

    We present the first photometric solution and frequency analysis of the neglected oscillating Algol-type (oEA) binary EW Boo. B- and V-band light curves of the star were obtained on 11 nights in 2014. Using the Wilson–Devinney code, the eclipsing light curves were synthesized and the first photometric solution was derived for the binary system. The results reveal that EW Boo could be a semi-detached system with the less-massive secondary component filling its Roche lobe. By subtracting the eclipsing light changes from the data, we obtained the intrinsic pulsating light curves of the hotter, massive primary component. Frequency analysis of residual light shows multi-mode pulsation with the dominant period at 0.01909 days. A preliminary mode identification suggests that the star could be pulsating in non-radial (l = 1) modes. The long-term orbital period variation of the system was also investigated for the first time. An improved orbital period and new ephemerides of the eclipsing binary are given. The O−C analysis indicates a secular period increasing at a rate of dP/dt=2.9×10 −7 days yr −1 , which could be interpreted as mass transfer from the cooler secondary to the primary component.

  12. Letramentos acadêmicos e multimodalidade em contexto de EaD semipresencial

    Directory of Open Access Journals (Sweden)

    Fabiana Komesu

    2012-07-01

    Full Text Available De uma perspectiva teórica enunciativo-discursiva, este artigo tem como objetivo discutir o processo de constituição do texto em contexto digital, de maneira particularizada, por meio da problematização de modos e recursos semióticos atualizados na produção acadêmica do universitário que utiliza computador com acesso à internet no processo de Educação a Distância (EaD semipresencial. Interessa investigar como o modelo de letramentos acadêmicos pode ser articulado ao estudo da multimodalidade, considerando-se que em ambiente eletrônico o universitário tem, por hipótese, acesso “ilimitado” a todo e qualquer texto, não apenas ao chamado “verbal”, comumente atribuído ao elemento gráfico. O conjunto do material é formado de textos produzidos por alunos do Curso de Pedagogia semipresencial da Universidade Virtual do Estado de São Paulo (UNIVESP no ano de 2010.Palavras-chave: Escrita. Letramentos. Discurso. Educação a distância. Internet.

  13. EA-MC Neutronic Calculations on IAEA ADS Benchmark 3.2

    Energy Technology Data Exchange (ETDEWEB)

    Dahlfors, Marcus [Uppsala Univ. (Sweden). Dept. of Radiation Sciences; Kadi, Yacine [CERN, Geneva (Switzerland). Emerging Energy Technologies

    2006-01-15

    The neutronics and the transmutation properties of the IAEA ADS benchmark 3.2 setup, the 'Yalina' experiment or ISTC project B-70, have been studied through an extensive amount of 3-D Monte Carlo calculations at CERN. The simulations were performed with the state-of-the-art computer code package EA-MC, developed at CERN. The calculational approach is outlined and the results are presented in accordance with the guidelines given in the benchmark description. A variety of experimental conditions and parameters are examined; three different fuel rod configurations and three types of neutron sources are applied to the system. Reactivity change effects introduced by removal of fuel rods in both central and peripheral positions are also computed. Irradiation samples located in a total of 8 geometrical positions are examined. Calculations of capture reaction rates in {sup 129}I, {sup 237}Np and {sup 243}Am samples and of fission reaction rates in {sup 235}U, {sup 237}Np and {sup 243}Am samples are presented. Simulated neutron flux densities and energy spectra as well as spectral indices inside experimental channels are also given according to benchmark specifications. Two different nuclear data libraries, JAR-95 and JENDL-3.2, are applied for the calculations.

  14. Integration of EA and IT service to improve performance at higher education organizations

    Directory of Open Access Journals (Sweden)

    Hermanto Agus

    2018-01-01

    Full Text Available One of the perceived benefits of the use of information technology is the increased accuracy and speed of information that greatly helped the operations of an institution or organization. Politeknik XYZ as one of the organizations / institutions in the field of education, now need to consider the strategic role of information technology in supporting academic activities and develop a wide range of academic services, especially for students. Accordingly, in this study has been carried out the planning and improvement of information technology services in accordance with EA and IT Service standards, based on analysis using ACMM maturity level. The end result of architectural planning and service enhancement developed with TOGAF and ITIL is to be used as a reference in the improvement the role of information systems and technology in supporting business process organizations at Polytechnic XYZ. This study demonstrates the importance of raising awareness of the interdependent relationship between architecture and quality of service management in the organization of information technology.

  15. Expedited response action proposal (EE/CA ampersand EA) for 200 West Area carbon tetrachloride plume

    International Nuclear Information System (INIS)

    1991-09-01

    The report contains the proposal for an expedited response action (ERA) for the remediation of carbon tetrachloride contamination in the unsaturated soils beneath the 200 West Area of the Hanford Site. It provides the US Environmental Protection Agency (EPA) and the Washington State Department of Ecology (Ecology) with information regarding the need for the ERA and an evaluation of alternatives to reduce the mobility, toxicity, and/or volume of the carbon tetrachloride in the unsaturated soils. This report is intended to aid the EPA and Ecology in selecting a preferred alternative for implementing the ERA. This proposal does not address remediation of carbon tetrachloride in the ground water underlying the 200 West Area; nor is the radioactive waste mixed with the carbon tetrachloride in the disposal site the subject of this ERA. This report has also been prepared to address the requirements for an environmental assessment (EA). The purpose of this ERA is to prevent, or at least minimize, further migration of carbon tetrachloride contamination from the unsaturated soils to uncontaminated areas. This action is needed to ensure that the environment and public health are adequately protected and to reduce the threat of further groundwater contamination. Information on the origin, nature, and extent of carbon tetrachloride (and co-contaminants), and other site characteristics used as a basis for evaluating remedial alternatives is presented

  16. Preliminary Studies of the Demonstration Plant of the Energy Amplifier (EA) by LAESA

    International Nuclear Information System (INIS)

    Abanades, A.; Nunez-Lagos, R.; Perez-Navarro, A.; Rubio, J.A.

    1998-01-01

    On July 1997, an international company named LAESA has finished its foundational period, with the headquarters in Zaragoza. The main initial goal of the company is, based on the conceptual design of an Energy Amplifier from C. Rubbia and collaborators, to take the necessary steps for developing the engineering design and the construction of a demonstration unit of EA (approx 100 MWt in its first phase and 250 MWt in the second one). The company will be mainly charged of the technical aspects required by the construction of the prototype and its funding comes both from private and public capital, as well as the selling of services. The prototype intends to use a final accelerator current of approx 12 mA and a beam energy close to 400 MeV. The construction period is expected to be 5 to t years and the initial emphasis of the installation is to demonstrate its capability for a massive incineration of long lived radioactive waste, with the corresponding energy generation. The necessary development to prepare de engineering design is being the subject of a R and D programme in Spain. Other countries with or without companies inside LAESA are also carrying on other Rand D programmes. The expected planning foresees an integrated R and D programme, a first version of the engineering design and the initial contacts both with the Spanish Nuclear Regulatory Commission, as well as the Spanish Environmental authorities. During the Conference, the status of the engineering design will be shown. (Author) 3 refs

  17. Revised analysis of the (1+1) EA for the minimum spanning tree problem

    DEFF Research Database (Denmark)

    Witt, Carsten

    2014-01-01

    We revisit the classical analysis of the (1+1) EA for the minimum spanning tree problem in the case that nothing is known about the weights of the underlying graph. Here the original upper bound on the expected running time by Neumann and Wegener [Theor. Comput. Sci. 378(1), 32-40, 2007], which...... depends on the largest weight of the graph, is of no use. The best upper bound available before in this case is due to Reichel and Skutella [FOGA 2009, 21-28] and is of order O(m3 \\log n), where m is the number of edges and n the number of vertices. Using an adaptive drift analysis, we show the improved...... bound O(m2 (sqrt{c(G)} + \\log n)), where c(G) is the circumference (length of the longest cycle) of the graph. This is only by an asymptotic factor of at most sqrt{n}/\\log n away from the classical lower bound. Furthermore, an alternative fitness function leading to the bound O(m2\\log n) is proposed...

  18. Azimuthal asymmetries of the charged particle densities in EAS in the range of KASCADE-Grande

    International Nuclear Information System (INIS)

    Sima, O.; Morariu, C.; Manailescu, C.; Rebel, H.; Haungs, A.

    2009-03-01

    The reconstruction of Extended Air Showers (EAS) observed by ground level particle detectors is based on the characteristics of observables like particle lateral density (PLD), arrival time signals etc. Lateral densities, inferred from detector data, are usually parameterized by applying various lateral distribution functions (LDF). The LDFs are used in turn for evaluating quantities like the total number of particles, the density at particular radial distances. Typical expressions for LDFs anticipate azimuthal symmetry of the density around the shower axis. The deviations of the particle lateral density from this assumption are smoothed out in the case of compact arrays like KASCADE, but not in the case of arrays like Grande, which only sample a smaller part of the azimuthal variation. In this report we discuss the origin of the asymmetry: geometric, attenuation and geomagnetic effects. Geometric effects occur in the case of inclined showers, due to the fact that the observations are made in a plane different from the intrinsic shower plane. Hence the projection procedure from the observational plane to the relevant normal shower plane plays a significant role. Attenuation effects arise from the differences between the distances travelled by particles that reach the ground at the same radial coordinate but with various azimuthal positions in the case of inclined showers. The influence of the geomagnetic field distorts additionally the charged particle distributions in a way specific to the geomagnetic location. Based on dedicated CORSIKA simulations we have evaluated the magnitude of the effects. Focused to geometric and attenuation effects, procedures for minimizing the effects of the azimuthal asymmetry of lateral density in the intrinsic shower plane were developed. The consequences of the reconstruction of the charge particle sizes determined with the Grande array are also discussed and a procedure for practical application of restoring the azimuthal symmetry

  19. Impacts of the EA and SCA patterns on the 20th century NAO-winter precipitation relationship in Europe

    Science.gov (United States)

    Comas-Bru, Laia; McDermott, Frank

    2013-04-01

    Much of the 20th century multi-decadal variability in the NAO-winter precipitation relationship over the N. Atlantic / European sector can be ascribed to the combined effects of the North Atlantic Oscillation (NAO) and either the East Atlantic pattern (EA) or the Scandinavian pattern (SCA). The NAO, EA and SCA indices employed here are defined as the three leading vectors of the cross-correlation matrix calculated from monthly sea-level pressure anomalies for 138 complete winters from the 20CRv2 dataset (Compo et al., 2011). Winter precipitation data over Europe for the entire 20th century is derived from the high resolution CRU-TS3.1 climate dataset (Mitchell and Jones, 2005). Here we document for the first time, that different NAO/EA and NAO/SCA combinations systematically influence winter precipitation conditions in Europe as a consequence of NAO dipole migrations. We find that the zero-correlated line of the NAO-winter precipitation relationship migrates southwards when the EA is in the opposite phase to the NAO. This can be related to a south-westwards migration of the NAO dipole under these conditions, as shown by teleconnectivity maps. Similarly, a clockwise movement of the NAO-winter climate correlated areas occurs when the phase of the SCA is opposite to that of the NAO, reflecting a clockwise movement of the NAO dipole under these conditions. An important implication of these migrations is that they influence the spatial and temporal stationarity of climate-NAO relationships. As a result, the link between winter precipitation patterns and the NAO is not straightforward in some regions such as the southern UK, Ireland and France. For instance, much of the inter-annual variability in the N-S winter precipitation gradient in the UK, originally attributed to inter-annual and inter-decadal variability of the NAO, reflects the migration of the NAO dipole, linked to linear combinations of the NAO and the EA. Our results indicate that when the N-S winter

  20. 3α-breakup-induced dynamical polarization potential of 12C at E/A >= 10 MeV

    International Nuclear Information System (INIS)

    Kubono, S.; Sugitani, M.; Tanaka, M.H.; Morita, K.; Sakuragi, Y.; Kamimura, M.

    1985-06-01

    The important role of the 3α-breakup processes to the optical potential of 12 C at E/A >= 10 MeV has been shown by observing directly the excitation of the 7.65-MeV 0 2 + state which breaks into 3α clusters. The 3α-breakup processes also explain well the previously unknown reduction factor for the exit-channel real potential for the same state. (author)

  1. Deeply inelastic collisions as a source of intermediate mass fragments at E/A = 27 MeV

    International Nuclear Information System (INIS)

    Borderie, B.; Montoya, M.; Rivet, M.F.; Jouan, D.; Cabot, C.; Fuchs, H.; Gardes, D.; Gauvin, H.; Jacquet, D.; Monnet, F.

    1988-01-01

    Intermediate-mass fragments detected in coincidence with heavy residues were measured in 40 Ar induced reactions on Ag at E/A = 27 MeV. From the observed characteristics, it is inferred that intermediate-mass fragments associated with the so-called intermediate-velocity source come mainly from deeply inelastic collisions occurring after or at the same time as preequilibrium particle emission. (orig.)

  2. Special report. Update on EAS (electronic article surveillance) systems: protecting against patient wandering, infant abduction, property theft.

    Science.gov (United States)

    1993-10-01

    Concern about wandering patients and infant abduction on the part of hospitals has sparked renewed interest in Electronic Article Surveillance (EAS) systems. Such systems had their origins in department stores and libraries where they are almost universally used. They also have applications in hospitals for preventing the theft of supplies and equipment. A number of companies provide EAS products for the health care field. How do you select the system that is best for your needs? "Talk to users. Pick out a number of profit and non-profit hospitals to get their views," advises Ted Algaier, vice president, marketing and sales, Innovative Control Systems, Inc., Waukesha, WI. "Examine the history of the company or vendor to determine if it understands the health care market and find out if the product really works." In this report, we'll review a number of EAS systems currently on the market, and present information on how they work, how effective they are, and costs involved. Also included are comments from users who have installed such systems.

  3. Characterization of the Defense Waste Processing Facility (DWPF) Environmental Assessment (EA) glass Standard Reference Material. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Jantzen, C.M.; Bibler, N.E.; Beam, D.C.; Crawford, C.L.; Pickett, M.A.

    1993-06-01

    Liquid high-level nuclear waste at the Savannah River Site (SRS) will be immobilized by vitrification in borosilicate glass. The glass will be produced and poured into stainless steel canisters in the Defense Waste Processing Facility (DWPF). Other waste form producers, such as West Valley Nuclear Services (WVNS) and the Hanford Waste Vitrification Project (HWVP), will also immobilize high-level radioactive waste in borosilicate glass. The canistered waste will be stored temporarily at each facility for eventual permanent disposal in a geologic repository. The Department of Energy has defined a set of requirements for the canistered waste forms, the Waste Acceptance Product Specifications (WAPS). The current Waste Acceptance Primary Specification (WAPS) 1.3, the product consistency specification, requires the waste form producers to demonstrate control of the consistency of the final waste form using a crushed glass durability test, the Product Consistency Test (PCI). In order to be acceptable, a waste glass must be more durable during PCT analysis than the waste glass identified in the DWPF Environmental Assessment (EA). In order to supply all the waste form producers with the same standard benchmark glass, 1000 pounds of the EA glass was fabricated. The chemical analyses and characterization of the benchmark EA glass are reported. This material is now available to act as a durability and/or redox Standard Reference Material (SRM) for all waste form producers.

  4. A Qualitative Evaluation of Contact Centre Dietitian Support and Electronic Motivational Messaging for eaTracker My Goals Users.

    Science.gov (United States)

    Lieffers, Jessica R L; Haresign, Helen; Mehling, Christine; Arocha, Jose F; Hanning, Rhona M

    2018-06-01

    To conduct a qualitative evaluation of adjunct supports (brief motivational messaging regarding goals delivered by email/website, contact centre dietitian assistance) offered by EatRight Ontario (ERO) for users of a website-based nutrition/activity goal setting/tracking feature (eaTracker "My Goals"). One-on-one semi-structured interviews were conducted with My Goals users in Ontario (n = 18) and Alberta (n = 5) recruited via the eaTracker website and ERO contact centre dietitians (n = 5). Interview transcripts were analyzed using content analysis. Participants had mixed experiences and perspectives with ERO motivational messaging. Messages targeted towards specific goals (e.g., tips, recipes) were generally well-liked, and generic messages (e.g., eaTracker login reminders) were less useful. No interviewed users had contacted ERO dietitians regarding goals, and dietitians reported encountering few callers asking for assistance while using My Goals. Limited user knowledge was one explanation for this finding. Participants provided suggestions to enhance these supports. Electronic motivational messaging and contact centre dietitian assistance have the potential to support achievement of goals set with website-based features. When considering using electronic messaging, researchers and practitioners should consider message content and delivery tailoring. Marketing that focuses on how contact centre dietitians can assist website users with their goals is needed when services are used in naturalistic settings.

  5. Ultrastructural changes in the membrane system of isolated chloroplasts of spinach under the influence of carbonic anhydrase inhibitors AA and EA

    Directory of Open Access Journals (Sweden)

    Marina V. Vodka

    2013-04-01

    Full Text Available The effects of carbonic anhydrase inhibitors (АА and EA on the membrane system of isolated chloroplasts of spinach were investigated. Under the influence of AA the considerable alterations in granal structure occurred, the thickness of the granal thylakoids increased by 36% and the interspace between thylakoids by 10% comparable with the control. As a result of EA treatment, the thickness of granal thylakoids enhanced by 31% and the interspace between thylakoids increased by 8% in comparison to the control. It was shown that structure of the granal system of the chloroplast was more sensitive to AA than EA. The data obtained can indicate a decrease in the activity of the thylakoid carbonic anhydrase, inhibition of electron transport and photosynthetic process as a whole in the presence of carbonic anhydrase inhibitors (AA and EA.

  6. Rate Constant and Temperature Dependence for the Reaction of Hydroxyl Radicals with 2-Flouropropane (FC-281ea) and Comparison with an Estimated Rate Constant

    Science.gov (United States)

    DeMore, W.; Wilson, E., Jr.

    1998-01-01

    Relative rate experiments were used to measure the rate constant and temperature dependence of the reaction of OH radicals with 2-fluoropropane (HFC-281ea), using ethane, propane, ethyl chloride as reference standards.

  7. Characteristics of EAS and primary particle mass composition in the energy region of 1017-3.1019 eV by Yakutsk data

    International Nuclear Information System (INIS)

    Knurenko, S.P.; Egorova, V.P.; Ivanov, A.A.; Kolosov, V.A.; Makarov, I.T.; Petrov, Z.E.; Sleptsov, I.Ye.; Struchkov, G.G.

    2006-01-01

    In this work the data of the Yakutsk complex EAS array and their comparison with calculation in the case of primary nuclei of different chemical elements are presented. The calculation by QGSJET model have been used interpreting experimental data

  8. Evaluation of RSDL, M291 SDK, 0.5 Bleach, 1% Soapy Water and SERPACWA: Part 11: Challenge with EA4243 (VR, Russian VX)

    Science.gov (United States)

    2016-01-01

    listed decontamination products in the haired guinea pig model following exposure to VR (Russian VX, EA4243). 15. SUBJECT TERMS decontamination...the efficacy of the barrier skin cream SERPACWA and the four listed decontamination products in the haired guinea pig model following exposure to VR...four listed decontamination products and SERPACWA in the haired guinea pig model following exposure to VR (Russian VX, EA4243, Soviet V-gas

  9. The genome of the Erwinia amylovora phage PhiEaH1 reveals greater diversity and broadens the applicability of phages for the treatment of fire blight.

    Science.gov (United States)

    Meczker, Katalin; Dömötör, Dóra; Vass, János; Rákhely, Gábor; Schneider, György; Kovács, Tamás

    2014-01-01

    The enterobacterium Erwinia amylovora is the causal agent of fire blight. This study presents the analysis of the complete genome of phage PhiEaH1, isolated from the soil surrounding an E. amylovora-infected apple tree in Hungary. Its genome is 218 kb in size, containing 244 ORFs. PhiEaH1 is the second E. amylovora infecting phage from the Siphoviridae family whose complete genome sequence was determined. Beside PhiEaH2, PhiEaH1 is the other active component of Erwiphage, the first bacteriophage-based pesticide on the market against E. amylovora. Comparative genome analysis in this study has revealed that PhiEaH1 not only differs from the 10 formerly sequenced E. amylovora bacteriophages belonging to other phage families, but also from PhiEaH2. Sequencing of more Siphoviridae phage genomes might reveal further diversity, providing opportunities for the development of even more effective biological control agents, phage cocktails against Erwinia fire blight disease of commercial fruit crops.

  10. Effects of the foliar-applied protein "Harpin(Ea)" (messenger) on tomatoes infected with Phytophthora infestans.

    Science.gov (United States)

    Fontanilla, M; Montes, M; De Prado, R

    2005-01-01

    The active ingredient in Messenger, is Harpin(Ea), a naturally occurring protein derived from Erwinia amylovora, a causal agent of fire blight. When Messenger is applied to a plant, the protein Harpin(Ea) binds foliar receptors to it. The receptors recognize the presence of Harpin(Ea), sending a signal that a pathogen is present, actually "tricking" the plant into thinking that it is under attack. This binding process triggers a cascade of responses affecting a global change of gene expressions, stimulating several distinct biochemical pathways within the plant responsible for growth and disease and insect resistance. The objective of this work is to characterize the development of an induced resistance against Phytophthora infestans. No effective treatment is currently available against this pathogenic agent, which causes the loss of complete harvests of different crops. Tomato plants with and without Messenger applications were inoculated with Phytophthora infestans in the same way. In addition, some plants with and without Messenger applications were not inoculated. Inoculated plants were symptomatologically checked for local and systemic symptoms. Evaluations of the number of tomatoes produced, with or without damage, and their growth, were also carried out. Based on the data obtained from the assays, significant changes were observed in the parameters measured due to Messenger treatment. The severe damage of this disease was reduced in the plants which received Messenger applications. These results open up new pathways in the control of diseases like Phytophthora infestans, in which effective means to combat them still do not exist, or these means are harmful to the environment.

  11. EurEAs_Gplex--A new SNaPshot assay for continental population discrimination and gender identification.

    Science.gov (United States)

    Daca-Roszak, P; Pfeifer, A; Żebracka-Gala, J; Jarząb, B; Witt, M; Ziętkiewicz, E

    2016-01-01

    Assays that allow analysis of the biogeographic origin of biological samples in a standard forensic laboratory have to target a small number of highly differentiating markers. Such markers should be easy to multiplex and the assay must perform well in the degraded and scarce biological material. SNPs localized in the genome regions, which in the past were subjected to differential selective pressure in various populations, are the most widely used markers in the studies of biogeographic affiliation. SNPs reflecting biogeographic differences not related to any phenotypic traits are not sufficiently explored. The goal of our study was to identify a small set of SNPs not related to any known pigmentation/phenotype-specific genes, which would allow efficient discrimination between populations of Europe and East Asia. The selection of SNPs was based on the comparative analysis of representative European and Chinese/Japanese samples (B-lymphocyte cell lines), genotyped using the Infinium HumanOmniExpressExome microarray (Illumina). The classifier, consisting of 24 unlinked SNPs (24-SNP classifier), was selected. The performance of a 14-SNP subset of this classifier (14-SNP subclassifier) was tested using genotype data from several populations. The 14-SNP subclassifier differentiated East Asians, Europeans and Africans with ∼100% accuracy; Palestinians, representative of the Middle East, clustered with Europeans, while Amerindians and Pakistani were placed between East Asian and European populations. Based on these results, we have developed a SNaPshot assay (EurEAs_Gplex) for genotyping SNPs from the 14-SNP subclassifier, combined with an additional marker for gender identification. Forensic utility of the EurEAs_Gplex was verified using degraded and low quantity DNA samples. The performance of the EurEAs_Gplex was satisfactory when using degraded DNA; tests using low quantity DNA samples revealed a previously not described source of genotyping errors, potentially

  12. Systematics of complex fragment emission from La induced reactions at E/A = 47 MeV

    International Nuclear Information System (INIS)

    Kehoe, W.L.; Mignerey, A.C.; Bradley, S.

    1989-03-01

    Complex fragment (Z > 2) emission was studied in the reverse kinematics reactions of 139 La on 27 Al and /sup nat./Cu at a bombarding energy of E/A = 47 MeV. Experimental results from inclusive and coincidence measurements for two- and three-fold complex fragments events are presented. Measured cross sections and Z 1 -Z 2 correlations show a predominately binary-decay process for the La + Al reaction, while the La + Cu reaction is dominated by multi-body decay. 18 refs., 9 figs., 1 tab

  13. Low modulation bias InGaN-based integrated EA-modulator-laser on semipolar GaN substrate

    KAUST Repository

    Shen, Chao; Leonard, John; Pourhashemi, Arash; Oubei, Hassan M.; Alias, Mohd Sharizal; Ng, Tien Khee; Nakamura, Shuji; DenBaars, Steven P.; Speck, James S.; Alyamani, Ahmed Y.; Eldesouki, Munir M.; Ooi, Boon S.

    2015-01-01

    In summary, we demonstrated the monolithic integration of electroabsorption modulator with laser diode and measured DC and AC modulation characteristics of the device, which is grown on (2021̅) plane GaN substrate. By alternating the modulation voltage at −3.5 V and 0 V, we achieve the laser output power of < 1.5 mW to > 9 mW, respectively, leading to ∼8.1 dB On/Off ratio. Our results clearly show that a low power consumption modulator can be achieved with semipolar EA-modulator compared to that of the c-plane devices.

  14. Low modulation bias InGaN-based integrated EA-modulator-laser on semipolar GaN substrate

    KAUST Repository

    Shen, Chao

    2015-10-06

    In summary, we demonstrated the monolithic integration of electroabsorption modulator with laser diode and measured DC and AC modulation characteristics of the device, which is grown on (2021̅) plane GaN substrate. By alternating the modulation voltage at −3.5 V and 0 V, we achieve the laser output power of < 1.5 mW to > 9 mW, respectively, leading to ∼8.1 dB On/Off ratio. Our results clearly show that a low power consumption modulator can be achieved with semipolar EA-modulator compared to that of the c-plane devices.

  15. The cosmic ray proton, helium and CNO fluxes in the 100 TeV energy region from TeV muons and EAS atmospheric Cherenkov light observations of MACRO and EAS-TOP

    CERN Document Server

    Aglietta, M; Ambrosio, M; Antolini, R; Antonioli, P; Arneodo, F; Baldini, A; Barbarino, G C; Barish, B C; Battistoni, G; Becherini, Y; Bellotti, R; Bemporad, C; Bergamasco, L; Bernardini, P; Bertaina, M; Bilokon, H; Bower, C; Brigida, M; Bussino, S; Cafagna, F; Calicchio, M; Campana, D; Carboni, M; Caruso, R; Castagnoli, C; Castellina, A; Cecchini, S; Cei, F; Chiarella, V; Chiarusi, T; Chiavassa, A; Choudhary, B C; Cini, G; Coutu, S; Cozzi, M; De Cataldo, G; De Marzo, C; De Mitri, I; De Vincenzi, M; Dekhissi, H; Derkaoui, J; Di Credico, A; Di Sciascio, G; Erriquez, O; Favuzzi, C; Forti, C; Fulgione, W; Fusco, P; Galeotti, P; Ghia, P L; Giacomelli, G; Giannini, G; Giglietto, N; Giorgini, M; Grassi, M; Grillo, A; Guarino, F; Gustavino, C; Habig, A; Hanson, K; Heinz, R; Iacovacci, M; Iarocci, E; Katsavounidis, E; Katsavounidis, I; Kearns, E; Kim, H; Kyriazopoulou, S; Lamanna, E; Lane, C; Levin, D S; Lipari, P; Longley, N P; Longo, M J; Loparco, F; Maaroufi, F; Mancarella, G; Mandrioli, G; Mannocchi, G; Margiotta, A; Marini, A; Martello, D; Marzari-Chiesa, A; Mazziotta, M N; Michael, D G; Monacelli, P; Montaruli, T; Monteno, M; Morello, C; Mufson, S; Musser, J; Navarra, G; Nicolò, D; Nolty, R; Orth, C; Osteria, G; Palamara, O; Patera, V; Patrizii, L; Pazzi, R; Peck, C W; Perrone, L; Petrera, S; D'Ettorre-Piazzoli, B; Popa, V; Rainó, A; Reynoldson, J; Ronga, F; Saavedra, O; Satriano, C; Scapparone, E; Scholberg, K; Sciubba, A; Sioli, M; Sirri, G; Sitta, M; Spinelli, P; Spinetti, M; Spurio, M; Stamerra, A; Steinberg, R; Stone, J L; Sulak, L R; Surdo, A; Tarle, G; Togo, V; Trinchero, G C; Vakili, M; Valchierotti, S; Vallania, P; Vernetto, S; Vigorito, C; Walter, C W; Webb, R; 10.1016/j.astropartphys.2004.01.005

    2004-01-01

    The primary cosmic ray (CR) proton, helium and CNO fluxes in the energy range 80-300 TeV are studied at the National Gran Sasso Laboratories by means of EAS-TOP (Campo Imperatore, 2005 m a.s.l.) and MACRO (deep underground, 3100 m w.e., the surface energy threshold for a muon reaching the detector being E/sub mu //sup th/ approximately=1.3 TeV). The measurement is based on: (a) the selection of primaries based on their energy/nucleon (i.e., with energy/nucleon sufficient to produce a muon with energy larger than 1.3 TeV) and the reconstruction of the shower geometry by means of the muons recorded by MACRO in the deep underground laboratories; (b) the detection of the associated atmospheric Cherenkov light (C.l.) signals by means of the C.l. detector of EAS-TOP. The C.l. density at core distance r>100 m is directly related to the total primary energy E/sub 0/. Proton and helium ("p+He") and proton, helium and CNO ("p +He+CNO") primaries are thus selected at E/sub 0/ approximately=80 Te V, and at E/sub 0/ appro...

  16. Optimal Mutation Rates for the (1+lambda) EA on OneMax Through Asymptotically Tight Drift Analysis

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2018-01-01

    We study the (1+) EA, a classical population-based evolutionary algorithm, with mutation probability c / n, where and are constant, on the benchmark function OneMax, which counts the number of 1-bits in a bitstring. We improve a well-established result that allows to determine the first hitting t...... that mutation rates up to 10% larger than the asymptotically optimal rate 1 / n minimize the expected runtime. However, in absolute terms the expected runtime does not change by much when replacing 1 / n with the optimal mutation rate....... drift is known. This reduces the analysis of expected optimization time to finding an exact expression for the drift. We then give an exact closed-form expression for the drift and develop a method to approximate it very efficiently, enabling us to determine approximate optimal mutation rates for the (1......+) EA for various parameter settings of c and and also for moderate sizes of n. This makes the need for potentially lengthy and costly experiments in order to optimize c for fixed n and for the optimization of OneMax unnecessary. Interestingly, even for moderate n and not too small it turns out...

  17. Northeast Empire Limited Partnership No. 2 Alternative Energy, Inc. and Maine Public Service Company (Docket No. EA-95): Environmental Assessment

    International Nuclear Information System (INIS)

    1992-05-01

    This environmental assessment (EA) has been prepared in connection with the application (the Application) by Alternative Energy, Inc. (AEI), Northeast Empire Limited Partnership number-sign 2 (the Partnership) and Maine Public Service Company (MPS and, collectively with AEI and the Partnership, the Applicants), filed on January 6, 1992, for authorization to transmit electric energy to a foreign country. The electric energy to be exported would be produced by a 39-megawatt (MW), wood-fired powerplant (the Project) to be developed by AEI and to be built by the Partnership in Ashland, Maine, which is located in MPS' service territory. In the Application, the Applicants requested authorization for MPS to transmit electricity generated by the Project from Maine through New Brunswick, Canada, on route back to the US for domestic use by Central Maine Power Company (MP). The need to cross the US -Canadian border arises due to the geography of the area and to facilitate access to an existing transmission line. None of the power will be used in Canada. This EA addresses the environmental impacts associated with the export of electric energy and the connected actions which are expected to result from the authorization of those exports. The electricity would be exported over cross-border transmission facilities maintained between MPS and New Brunswick Power Corporation (NB Power). No new cross-border facilities, and no modification of any existing cross-border facilities, are required in connection with the proposed action

  18. Differentiation of lard, chicken fat, beef fat and mutton fat by GCMS and EA-IRMS techniques.

    Science.gov (United States)

    Ahmad Nizar, Nina Naquiah; Nazrim Marikkar, Jalaldeen Mohamed; Hashim, Dzulkifly Mat

    2013-01-01

    A study was conducted to differentiate lard, chicken fat, beef fat and mutton fat using Gas Chromatography Mass Spectrometry (GC-MS) and Elemental Analyzer-Isotope Ratio Mass Spectrometry (EA-IRMS). The comparison of overall fatty acid data showed that lard and chicken fat share common characteristics by having palmitic, oleic and linoleic acid as major fatty acids while beef and mutton fats shared common characteristics by possessing palmitic, stearic and oleic acid as major fatty acids. The direct comparisons among the fatty acid data, therefore, may not be suitable for discrimination of different animal fats. When the fatty acid distributional data was subjected to Principle Component Analysis (PCA), it was demonstrated that stearic, oleic and linoleic acids as the most discriminating parameters in the clustering of animal fats into four subclasses. The bulk carbon analysis of animal fats using EA-IRMS showed that determination of the carbon isotope ratios (δ¹³C) would be a good indicator for discriminating lard, chicken fat, beef fat and mutton fat. This would lead to a faster and more efficient method to ascertain the source of origin of fats used in food products.

  19. Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Enrique Gallego-Colon

    2015-01-01

    Full Text Available Strategies to limit damage and improve repair after myocardial infarct remain a major therapeutic goal in cardiology. Our previous studies have shown that constitutive expression of a locally acting insulin-like growth factor-1 Ea (IGF-1Ea propeptide promotes functional restoration after cardiac injury associated with decreased scar formation. In the current study, we investigated the underlying molecular and cellular mechanisms behind the enhanced functional recovery. We observed improved cardiac function in mice overexpressing cardiac-specific IGF-1Ea as early as day 7 after myocardial infarction. Analysis of gene transcription revealed that supplemental IGF-1Ea regulated expression of key metalloproteinases (MMP-2 and MMP-9, their inhibitors (TIMP-1 and TIMP-2, and collagen types (Col 1α1 and Col 1α3 in the first week after injury. Infiltration of inflammatory cells, which direct the remodelling process, was also altered; in particular there was a notable reduction in inflammatory Ly6C+ monocytes at day 3 and an increase in anti-inflammatory CD206+ macrophages at day 7. Taken together, these results indicate that the IGF-1Ea transgene shifts the balance of innate immune cell populations early after infarction, favouring a reduction in inflammatory myeloid cells. This correlates with reduced extracellular matrix remodelling and changes in collagen composition that may confer enhanced scar elasticity and improved cardiac function.

  20. The Interplay of Population Size and Mutation Probability in the (1+λ) EA on OneMax

    DEFF Research Database (Denmark)

    Gießen, Christian; Witt, Carsten

    2017-01-01

    The ((Formula presented.)) EA with mutation probability c / n, where (Formula presented.) is an arbitrary constant, is studied for the classical OneMax function. Its expected optimization time is analyzed exactly (up to lower order terms) as a function of c and (Formula presented.). It turns out...... that 1 / n is the only optimal mutation probability if (Formula presented.), which is the cut-off point for linear speed-up. However, if (Formula presented.) is above this cut-off point then the standard mutation probability 1 / n is no longer the only optimal choice. Instead, the expected number...... of generations is (up to lower order terms) independent of c, irrespectively of it being less than 1 or greater. The theoretical results are obtained by a careful study of order statistics of the binomial distribution and variable drift theorems for upper and lower bounds. Experimental supplements shed light...

  1. Charge correlations in the breakup of gold projectiles in reactions at E/A=600 MeV

    International Nuclear Information System (INIS)

    Kreutz, P.

    1992-09-01

    In the present thesis the charge correlations in the breakup of gold projectiles in heavy ion collisions at an incident energy of E/A=600 MeV were studied. Thereby it has been proved that the sum of the charges from the projectile source under exclusion of the protons (Z bound ) is saliently suited for the classification of the nuclear reactions. At large values of Z bound we fins fission and spallation reactions. For smaller values of Z bound we observe events with an increasing number of medium-heavy fragments. Thereby the multifragment events appear in the Dalitz diagrams as a continuation of more symmetric becoming spallation events. In reactions with Z bound ≅ 35 the conditions for the formation of medium-heavy fragments are optimal and the multifragment events represent the dominating exit channel. A mean multiplicity of the medium-heavy fragments of ≅ 4 is reached. (orig./HSI) [de

  2. Carta Acuerdo Dirección de EaD - y Dirección SeDiCI

    OpenAIRE

    Universidad Nacional de La Plata; Dirección de Educación a Distancia, Innovación en el aula y TIC (EAD)

    2012-01-01

    Establecer un marco de colaboración técnica entre la Dirección de Educación a Distancia Innovación en el aula y TIC (EaD) y el Servicio de Difusión de la Creación Intelectual (SeDiCI) de la UNLP, de modo de potenciar el desarrollo de actividades conjuntas en temas de interés común, aprovechando al máximo los recursos humanos y de infraestructura con los que cuentan. En este contexto crear un Repositorio Abierto de Objetos de Aprendizaje (OA) que permita integrar la producción de la UNLP y ...

  3. The Israeli EA-FEL Upgrade Towards Long Pulse Operation for Ultra-High Resolution Single Pulse Coherent Spectroscopy

    CERN Document Server

    Gover, A; Kanter, M; Kapilevich, B; Litvak, B; Peleg, S; Socol, Y; Volshonok, M

    2005-01-01

    The Israeli Electrostatic Accelerator FEL (EA-FEL) is now being upgraded towards long pulse (1005s) operation and ultra-high resolution (10(-6)) single pulse coherent spectroscopy. We present quantitative estimations regarding the applications of controlled radiation chirp for spectroscopic applications with pulse-time Fourier Transform limited spectral resolution. Additionally, we describe a novel extraction-efficiency-improving scheme based on increase of accelerating voltage (boosting) after saturation is achieved. The efficiency of the proposed scheme is confirmed by theoretical and numerical calculations. The latter are performed using software, based on 3D space-frequency domain model. The presentation provides an overview of the upgrade status: the high-voltage terminal is being reconfigured to accept the accelerating voltage boost system; a new broad band low-loss resonator is being manufactured; multi-stage depressed collector is assembled.

  4. Influence of combined impact and cyclic loading on the overall fatigue life of forged steel, EA4T

    Energy Technology Data Exchange (ETDEWEB)

    Malekzadeh, A.; Hadidi-Moud, S.; Farhangdoost, Kh [Ferdowsi University of Mashhad, Mashhad (Iran, Islamic Republic of)

    2017-03-15

    The performance of forged steel, EA4T, used in rail industry, under simulated in service conditions, i.e. combined impact - cyclic loading, was investigated through a comprehensive experimental programme. The standard Paris-Erdogan fatigue design curve parameters, m and C, were calibrated to account for the effect of the impact component of loading. A minimum threshold for impact load component, identified in the experiments, was also incorporated in the proposed empirical model. Comparison with experimental findings indicated that this “modified” Fatigue design curve could predict the fatigue life of pre impact loaded specimens with sufficient accuracy. It was therefore suggested that the modified model may be used as a novel design tool for predicting the overall fatigue life of components made of this material under the specified combined impact and fatigue loading conditions.

  5. Study on Soap-free P(MMA-EA-AA/MAA) Latex Particles With Narrow Size Distribution

    Institute of Scientific and Technical Information of China (English)

    K. Kang; C. Y. Kan; Y. Du; D. S. Liu

    2005-01-01

    @@ 1Introduction In the past decades, more and more studies have been focused on the synthesis of monodisperse particles with different diameter by special polymerization technique. In 1980' s, Ugelstad, et al[1] invented two-step swelling method to prepare monodisperse microsphere with large size more than 1 μm. In the following decade, Okubo and his coworkers[2] synthesized monodisperse crosslinked polymer particles above 3 μm using one-step dynamic swelling method. New method has been developed to produce particles more than 50 μm in diameter with a standard deviation of less than 2%[3]. Up to now, most of the monodisperse particles were usually prepared by polymerization of St in the presence of surfactants. In this presentation, sub-micro sized P (MMA-EA-AA/MAA) particles with narrow size distribution were prepared by seeded emulsion polymerization in the absence of any surfactant materials.

  6. Hadronic cosmic ray interactions near the LHC energy region and in the UHE domain of giant EAS

    Energy Technology Data Exchange (ETDEWEB)

    Capdevielle, J.N. [AstroParticule et Cosmologie (APC), College de France, 75 - Paris (France)

    2005-07-01

    The fluctuations of ray families simulated with CORSIKA in the energy region 3.10{sup 15} - 10{sup 17} eV on the basis of standard Lns collider physics exhibits alignments of secondaries in the stratosphere and at ground level. The remarkable event recorded on the Concorde does not fit well however those cases. The possible hints of new mechanisms, especially the valence diquark breaking, are considered. Observing that the extrapolation of the original cosmic ray primary spectrum derived from the size spectrum measured in the Akeno classical EAS array coincides with the spectrum measured recently by the Hires Stereo experiment, we point out a possible overestimation of the primary energy in inclined showers of the surface arrays like AGASA. (author)

  7. Heat partition in the E/A=8.5 MeV 74Ge+165Ho reaction

    International Nuclear Information System (INIS)

    Kwiatkowski, K.; Planeta, R.; Zhou, S.H.; Viola, V.E.; Breuer, H.; McMahan, M.A.; Mignerey, A.C.

    1990-01-01

    The excitation-energy distribution of projectilelike fragments formed in the E/A=8.5 MeV 74 Ge+ 165 Ho reaction has been obtained by applying a statistical evaporation calculation to the difference between primary fragment mass yields derived from kinematic coincidence measurements and directly measured yields. A gradual transition from approximate equipartition of excitation energy for small energy losses to a division that favors the targetlike fragment for highly damped events is observed, in agreement with previous measurements. For a given energy loss, heat partition is found to correlate with the direction of net nucleon transfer. The variances of the excitation-energy distributions are shown to increase monotonically as a function of energy loss. The average data are compared with predictions of the nucleon exchange transport model. The results suggest that energy-loss mechanisms in addition to nucleon exchange may be important in the early stages of the collision

  8. New aspects in nucleon-nucleus collisions and EAS properties around 10(6) GeV

    International Nuclear Information System (INIS)

    Capdevielle, J.N.; Gawin, J.

    1985-01-01

    At energies higher than 2 x 10 to the 5 GeV, very little information exists on detailed properties of nucleon-nucleon collision; the rare elements are coming from jets and as nondirect improvements from gamma-ray families. The results exhibit some conflicting features, or at least, very large fluctuations like copious production of gamma rays in opposition to Centauro-like events, which suggest that phase transition to quark-gluon plasma occurs in nucleus-nucleus collisions and even in nucleon-nucleus collision. The multicluster phenomenological model (MPM) is extrapolated for EAS simulation up to 5 x 10 to the 6 GeV to put in evidence some significant deviation between experimental data and prediction

  9. Headspace solid phase microextraction--GC/C-IRMS for delta13CVPDB measurements of mono-aromatic hydrocarbons using EA-IRMS calibration.

    Science.gov (United States)

    Ebongué, Véronique Woule; Geypens, Benny; Berglund, Michael; Taylor, Philip

    2009-03-01

    This work aims at comparing the delta(13)C(VPDB) of mono-aromatic hydrocarbons benzene, toluene, ethylbenzene and xylene isomers (BTEX) measured by elemental analyser (EA)-isotope ratio mass spectrometer (IRMS) with the delta(13)C(VPDB) measured on the same compounds by headspace solid phase microextraction - GC/C-IRMS (hSPME - GC/C-IRMS) with the final goal of using these compounds as internal standards on the latter system. The EA-IRMS measurements were done using calcium and lithium carbonate isotopic reference materials: NBS19 and L-SVEC for establishing the delta(13)C(VPDB) scale. The EA-IRMS measurements with helium dilution of a set of five reference materials (USGS40, USGS41, IAEA-CH-6, IAEA-CH-3 and IAEA-601) show systematic bias of 1 per thousand relative to their assigned values. This bias due to the dilution mechanism in the used ConfloII interface device could not be avoided. As the selected hydrocarbons: BTEX could not be analysed by EA-IRMS without helium dilution, their delta(13)C(VPDB) must be corrected from this observed bias using an external calibration. The CO(2) gas calibrated using EA-IRMS without helium dilution, was used as an in-house reference for the delta(13)C(VPDB) measurements of the BTEX by the hSPME - GC/C-IRMS system. The comparison made between the delta(13)C(VPDB) measured on the same BTEX compounds by EA-IRMS (with external calibration) and by hSPME - GC/C-IRMS techniques showed good agreement.

  10. A Gaussian mixture clustering model for characterizing football players using the EA Sports' FIFA video game system. [Modelo basado en agrupamiento de mixturas Gaussianas para caracterizar futbolistas utilizando el sistema de videojuegos FIFA de EA Sports].

    Directory of Open Access Journals (Sweden)

    César Soto-Valero

    2017-07-01

    Full Text Available The generation and availability of football data has increased considerably last decades, mostly due to its popularity and also because of technological advances. Gaussian mixture clustering models represents a novel approach to exploring and analyzing performance data in sports. In this paper, we use principal components analysis in conjunction with a model-based Gaussian clustering method with the purpose of characterizing professional football players. Our model approach is tested using 40 attributes from EA Sports' FIFA video game series system, corresponding to 7705 European players. Clustering results reveal a clear distinction among different performance indicators, representing four different roles in the team. Players were labeled according to these roles and a gradient tree boosting model was used for ranking attributes regarding to its importance. We found that the dribbling skill is the most discriminating variable among the different clustered players’ profiles. Resumen En las últimas décadas se ha visto un incremento considerable en la generación y disponibilidad de datos de fútbol, esto se debe fundamentalmente a la popularidad de este deporte así como a los avances tecnológicos realizados en este campo. Los modelos de agrupamiento basados en mixturas Gaussianas representan un enfoque novedoso para explorar y analizar datos de desempeño deportivo. En el presente trabajo, se lleva a cabo una caracterización de jugadores profesionales de fútbol utilizando técnicas de análisis de componentes principales y agrupamiento basados en mixturas Gaussianas. El modelo presentado es comprobado utilizando datos del sistema de videojuegos FIFA de EA Sports, dichos datos representan 40 atributos correspondientes a 7705 futbolistas europeos. Los resultados del agrupamiento revelan una clara distinción entre algunos indicadores de desempeño, los cuales corresponden a cuatro roles diferentes en el equipo. Consecuentemente, los

  11. E+A Galaxy Properties and Post-Starburst Galaxy Evolution Data through SDSS-IV MaNGA and Illustris: A Co-Analysis

    Science.gov (United States)

    Ojanen, Winonah; Dudley, Raymond; Edwards, Kay; Gonzalez, Andrea; Johnson, Amalya; Kerrison, Nicole; Marinelli, Mariarosa; Melchert, Nancy; Liu, Charles; Sloan Collaboration, SDSS-IV MaNGA

    2018-01-01

    E+A galaxies (Elliptical + A-type stars) are post-starburst galaxies that have experienced a sudden quenching phase. Using previous research methods, 39 candidates out of 2,812 galaxies observed, or 1.4%, were selected from the SDSS-IV MaNGA survey. We then identified morphological characteristics of the 39 galaxies including stellar kinematics, Gini coefficient, gas density and distribution and stellar ages. To study the origin of how E+A galaxies evolved to their present state, galaxy simulation data from the Illustris simulation was utilized to identify similar quenched post-starburst candidates. Seven post-starburst candidates were identified through star formation rate histories of Illustris simulated galaxies. The evolution of these galaxies is studied from 0 to 13.8 billion years ago to identify what caused the starburst and quenching of the Illustris candidates. Similar morphological characteristics of Illustris post-starburst candidates are pulled from before, during, and post-starburst and compared to the same morphological characteristics of the E+A galaxies from SDSS-IV MaNGA. The characteristics and properties of the Illustris galaxies are used to identify the possible evolutionary histories of the observed E+A galaxies. This work was supported by grants AST-1460860 from the National Science Foundation and SDSS FAST/SSP-483 from the Alfred P. Sloan Foundation to the CUNY College of Staten Island.

  12. Correlations of light particles in the reaction 40Ar on 197Au at E/A=200 MeV

    International Nuclear Information System (INIS)

    Kunde, G.J.

    1990-08-01

    For the study of small-angle correlations of light particles an experiment at the SATURNE synchrotron with 40 Ar on 197 Au at an incident energy of E/A=200 MeV was performed. A hodoscope consisting of an 8x8 matrix of silicon-cesium iodide detectors was applied under a mean angle of 40 degrees. The evaluation of the coincident particle information was performed via correlation functions, which were determined for systems with Z ≤ = 3. For three different fragments emission temperatures were measured via the determination of population ratios for particle-unstable states. Furthermore by means of p-p correlations the reaction volume was studied. The results are: For 5 Li a mean emission temperature of 6.4 -1.0 1.1 MeV resulted, for 4 He a mean emission temperature of 5.4 -1.2 +1.8 MeV was found. The temperature of 2.3 -0.2 0.6 MeV determined for 8 Be is strongly influenced by feeding. For the states at 21.1 and 22.1 MeV in 4 He a dependence of the temperature on the kinetic sum energy of the coincident particles was found, a temperature growth with increasing sum energy of about 3 MeV over the measured range of the sum energies resulted. Via p-p correlations a source radius of 5.8 ± 0.3 fm was determined. The correction for protons from sequential decays leads to radii, which are about 1 fm smaller. The radii and radius ratios for different ranges of the sum energy of the protons were analyzed. The measured emission temperatures are about 1 MeV higher than the values for the same system at E/A = 60 MeV. The temperatures correspond in the model of the statistical multifragmentation to an excitation energy of about 2 GeV, while they follow in the model of the sequential fragment emission for an excitation energy of about 1 GeV. (orig.) [de

  13. δ15N measurement of organic and inorganic substances by EA-IRMS: a speciation-dependent procedure.

    Science.gov (United States)

    Gentile, Natacha; Rossi, Michel J; Delémont, Olivier; Siegwolf, Rolf T W

    2013-01-01

    Little attention has been paid so far to the influence of the chemical nature of the substance when measuring δ(15)N by elemental analysis (EA)-isotope ratio mass spectrometry (IRMS). Although the bulk nitrogen isotope analysis of organic material is not to be questioned, literature from different disciplines using IRMS provides hints that the quantitative conversion of nitrate into nitrogen presents difficulties. We observed abnormal series of δ(15)N values of laboratory standards and nitrates. These unexpected results were shown to be related to the tailing of the nitrogen peak of nitrate-containing compounds. A series of experiments were set up to investigate the cause of this phenomenon, using ammonium nitrate (NH(4)NO(3)) and potassium nitrate (KNO(3)) samples, two organic laboratory standards as well as the international secondary reference materials IAEA-N1, IAEA-N2-two ammonium sulphates [(NH(4))(2)SO(4)]-and IAEA-NO-3, a potassium nitrate. In experiment 1, we used graphite and vanadium pentoxide (V(2)O(5)) as additives to observe if they could enhance the decomposition (combustion) of nitrates. In experiment 2, we tested another elemental analyser configuration including an additional section of reduced copper in order to see whether or not the tailing could originate from an incomplete reduction process. Finally, we modified several parameters of the method and observed their influence on the peak shape, δ(15)N value and nitrogen content in weight percent of nitrogen of the target substances. We found the best results using mere thermal decomposition in helium, under exclusion of any oxygen. We show that the analytical procedure used for organic samples should not be used for nitrates because of their different chemical nature. We present the best performance given one set of sample introduction parameters for the analysis of nitrates, as well as for the ammonium sulphate IAEA-N1 and IAEA-N2 reference materials. We discuss these results considering the

  14. Automatic and integrated micro-enzyme assay (AIμEA) platform for highly sensitive thrombin analysis via an engineered fluorescence protein-functionalized monolithic capillary column.

    Science.gov (United States)

    Lin, Lihua; Liu, Shengquan; Nie, Zhou; Chen, Yingzhuang; Lei, Chunyang; Wang, Zhen; Yin, Chao; Hu, Huiping; Huang, Yan; Yao, Shouzhuo

    2015-04-21

    Nowadays, large-scale screening for enzyme discovery, engineering, and drug discovery processes require simple, fast, and sensitive enzyme activity assay platforms with high integration and potential for high-throughput detection. Herein, a novel automatic and integrated micro-enzyme assay (AIμEA) platform was proposed based on a unique microreaction system fabricated by a engineered green fluorescence protein (GFP)-functionalized monolithic capillary column, with thrombin as an example. The recombinant GFP probe was rationally engineered to possess a His-tag and a substrate sequence of thrombin, which enable it to be immobilized on the monolith via metal affinity binding, and to be released after thrombin digestion. Combined with capillary electrophoresis-laser-induced fluorescence (CE-LIF), all the procedures, including thrombin injection, online enzymatic digestion in the microreaction system, and label-free detection of the released GFP, were integrated in a single electrophoretic process. By taking advantage of the ultrahigh loading capacity of the AIμEA platform and the CE automatic programming setup, one microreaction column was sufficient for many times digestion without replacement. The novel microreaction system showed significantly enhanced catalytic efficiency, about 30 fold higher than that of the equivalent bulk reaction. Accordingly, the AIμEA platform was highly sensitive with a limit of detection down to 1 pM of thrombin. Moreover, the AIμEA platform was robust and reliable to detect thrombin in human serum samples and its inhibition by hirudin. Hence, this AIμEA platform exhibits great potential for high-throughput analysis in future biological application, disease diagnostics, and drug screening.

  15. Effect of smoking on EA and NOS expression as well as NO and ET-1 content in gingival tissue of patients with chronic periodontitis

    Directory of Open Access Journals (Sweden)

    Ying Feng

    2017-02-01

    Full Text Available Objective: To study the effect of smoking on EA and NOS expression as well as NO and ET-1 content in gingival tissue of patients with chronic periodontitis. Methods: Patients diagnosed with periodontitis in our hospital between May 2013 and March 2016 were selected to screen 72 cases of smokers and 80 cases of non-smokers who were enrolled in smoking group and non-smoking group respectively, periodontal tissue was collected to detect the expression of EA, NOS and NLRP3 inflammasome, and gingival crevicular fluid was collected to detect the content of ET-1, NO, inflammatory factors and MMPs. Results: EA expression and ET-1 content in gingival tissue of smoking group were significantly higher than those of nonsmoking group while NOS expression and NO content in gingival tissue were significantly lower than those of non-smoking group; NLRP3, ASC, Caspase-1, IL-1β and IL-18 expression in gingival tissue of smoking group were significantly higher than those of nonsmoking group, and IL-1β, IL-18, TNF-α, IFN-γ, MMP1, MMP8 and MMP13 content in gingival crevicular fluid were significantly higher than those of non-smoking group; NLRP3, ASC, Caspase-1, IL-1β and IL-18 expression as well as IL-1β, IL-18, TNF-α, IFN-γ, MMP1, MMP8 and MMP13 content were positively correlated with EA and ET-1, and negatively correlated with NOS and NO. Conclusion: Smoking can cause increased EA and ET-1 as well as decreased NOS and NO in gingival tissue of patients with chronic periodontitis, thus adjusting the expression of NLRP3 inflammasome and MMPs to periodontal tissue inflammation and structure damage.

  16. ALTERED EXPRESSION OF SURFACE RECEPTORS AT EA.HY926 ENDOTHELIAL CELL LINE INDUCED WITH PLACENTAL SECRETORY FACTORS

    Directory of Open Access Journals (Sweden)

    O. I. Stepanova

    2012-01-01

    Full Text Available Abstract. Placental cell populations produce a great variety of angiogenic factors and cytokines than control angiogenesis in placenta. Functional regulation of endothelial cells proceeds via modulation of endothelial cell receptors for endogenous angiogenic and apoptotic signals. Endothelial phenotype alteration during normal pregnancy and in cases of preclampsia is not well understood. The goal of this investigation was to evaluate altered expression of angiogenic and cytokine receptors at EA.hy926 endothelial cells under the influence of placental tissue supernatants. Normal placental tissue supernatants from 1st and 3rd trimesters, and pre-eclamptic placental tissue supernatants (3rd trimester stimulated angiogenic and cytokine receptors expression by the cultured endothelial cells, as compared with their background expression. Tissue supernatants from placental samples of 3rd trimester caused a decreased expression of angiogenic and cytokine receptors by endothelial cells, thus reflecting maturation of placental vascular system at these terms. Supernatants from preeclamptic placental tissue induced an increase of CD119 expression, in comparison with normal placental supernatants from the 3rd trimester. This finding suggests that IFNγ may be a factor of endothelial activation in pre-eclampsia. The study was supported by grants ГК №02.740.11.0711, НШ-3594.2010.7., and МД-150.2011.7.

  17. Enterprise Architecture (EA) Roadmap

    Data.gov (United States)

    Office of Personnel Management — The Enterprise Roadmap reflects the information technology (IT) investment priorities established in agency PortfolioStat reviews, as well as IT program decisions...

  18. A continuum of H- to He-rich tidal disruption candidates with a preference for E+A galaxies

    Energy Technology Data Exchange (ETDEWEB)

    Arcavi, Iair; Gal-Yam, Avishay; Horesh, Assaf; Ofek, Eran O.; De Cia, Annalisa; Tal, David [Department of Particle Physics and Astrophysics, The Weizmann Institute of Science, Rehovot 76100 (Israel); Sullivan, Mark [School of Physics and Astronomy, University of Southampton, Southampton SO17 1BJ (United Kingdom); Pan, Yen-Chen [Department of Physics (Astrophysics), University of Oxford, DWB, Keble Road, Oxford OX1 3RH (United Kingdom); Cenko, S. Bradley [Astrophysics Science Division, NASA Goddard Space Flight Center, Mail Code 661, Greenbelt, MD 20771 (United States); Yan, Lin; Yang, Chen-Wei [Infrared Processing and Analysis Center, California Institute of Technology, Pasadena, CA 91125 (United States); Howell, D. A. [Las Cumbres Observatory Global Telescope, 6740 Cortona Drive, Suite 102, Goleta, CA 93111 (United States); Kulkarni, Shrinivas R.; Tendulkar, Shriharsh P.; Cohen, Judith G. [Cahill Center for Astrophysics, California Institute of Technology, Pasadena, CA 91125 (United States); Tang, Sumin [Kavli Institute for Theoretical Physics, University of California, Santa Barbara, CA 93106 (United States); Xu, Dong [Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 København Ø (Denmark); Sternberg, Assaf [Excellence Cluster Universe, Technische Universität München, Boltzmann Strasse 2, D-85748 Garching (Germany); Bloom, Joshua S.; Nugent, Peter E., E-mail: iarcavi@lcogt.net [Department of Astronomy, University of California, Berkeley, CA 94720 (United States); and others

    2014-09-20

    We present the results of a Palomar Transient Factory (PTF) archival search for blue transients that lie in the magnitude range between 'normal' core-collapse and superluminous supernovae (i.e., with –21 ≤ M {sub R} {sub (peak)} ≤ – 19). Of the six events found after excluding all interacting Type IIn and Ia-CSM supernovae, three (PTF09ge, 09axc, and 09djl) are coincident with the centers of their hosts, one (10iam) is offset from the center, and a precise offset cannot be determined for two (10nuj and 11glr). All the central events have similar rise times to the He-rich tidal disruption candidate PS1-10jh, and the event with the best-sampled light curve also has similar colors and power-law decay. Spectroscopically, PTF09ge is He-rich, while PTF09axc and 09djl display broad hydrogen features around peak magnitude. All three central events are in low star formation hosts, two of which are E+A galaxies. Our spectrum of the host of PS1-10jh displays similar properties. PTF10iam, the one offset event, is different photometrically and spectroscopically from the central events, and its host displays a higher star formation rate. Finding no obvious evidence for ongoing galactic nuclei activity or recent star formation, we conclude that the three central transients likely arise from the tidal disruption of a star by a supermassive black hole. We compare the spectra of these events to tidal disruption candidates from the literature and find that all of these objects can be unified on a continuous scale of spectral properties. The accumulated evidence of this expanded sample strongly supports a tidal disruption origin for this class of nuclear transients.

  19. Study the Stability of SSR Repeats of pEA29 Plasmid of the Casual Agent of Fire Blight

    Directory of Open Access Journals (Sweden)

    S. Baghaee Ravari

    2016-02-01

    Full Text Available Introduction Fire blight disease causes by Erwinia amylovora infects a wide variety of rosaceous plants. It was first recorded from pear trees in Karaj in year 1990. After that it was observed in many pear and apple orchards of the country. E. amylovora isolates differed slightly in virulence, symptoms and host range which ca be related to different plasmid content. The presence of an universal plasmid, pEA29, has been observed in majority of E. amylovora strains. Short-sequence DNA repeat with eight nt were repeated 3 to 15 times in the PstI fragment of the pEA29 plasmid. Here, the stability of SSR units and efficiency of this method to categorize strains was checked. For this reseaon two methods including amplification and cloning of whole and part of PstI fragment was done and the sequences were compared to eachother. In addition stability was evaluated based on three treatments including long time propagation, keeping strains in cold situation and re-isolation of infected tissues. Materials and Methods In this study 20 strains were purchased from the Iranian Plant Protection Research Institute. Their typical phenotypic tests were examined for all strains. All of then were checked with lateral flow immune chromatography in different serial dilutions. The pathogenicity were aassayed using complete fruit. Direct PCR with A/B primers and nested PCR with AJ75/AJ76 were applied for studied strains. Ten representative strains were selected snf part of PstI fragment amplified using RS1/RS2 primers. The PCR products were purified by QIAquick PCR purification kit (Qiagen, USA, cloned in pGEM-T and were sequenced (Macrogen Inc., Korea. Five of 10 were chosen for stability tests including long time propagation and sub culturing each two week for three months, keeping strains in refrigerator for three months and re-isolation of infected tissues. Results and Discussion In phenotypic tests all studies strains were facultative anaerobic growth, oxidase

  20. Prevalence of E/A wave fusion and A wave truncation in DDD pacemaker patients with complete AV block under nominal AV intervals.

    Directory of Open Access Journals (Sweden)

    Wolfram C Poller

    Full Text Available Optimization of the AV-interval (AVI in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB under the pre-programmed AVI. We manually optimized sub-optimal AVI.We analyzed 160 pacemaker patients with complete AVB, both in sinus rhythm (AV-sense; n = 129 and under atrial pacing (AV-pace; n = 31. Using Doppler analyses of the transmitral inflow we classified the nominal AVI as: a normal, b too long (E/A wave fusion or c too short (A wave truncation. In patients with a sub-optimal AVI, we performed manual optimization according to the recommendations of the American Society of Echocardiography.All AVB patients with atrial pacing exhibited a normal transmitral inflow under the nominal AV-pace intervals (100%. In contrast, 25 AVB patients in sinus rhythm showed E/A wave fusion under the pre-programmed AV-sense intervals (19.4%; 95% confidence interval (CI: 12.6-26.2%. A wave truncations were not observed in any patient. All patients with a complete E/A wave fusion achieved a normal transmitral inflow after AV-sense interval reduction (mean optimized AVI: 79.4 ± 13.6 ms.Given the rate of 19.4% (CI 12.6-26.2% of patients with a too long nominal AV-sense interval, automatic algorithms may prove useful in improving cardiac hemodynamics, especially in the subgroup of atrially triggered pacemaker patients with AV node diseases.

  1. Simulating the energy deposits of particles in the KASCADE-grande detector stations as a preliminary step for EAS event reconstruction

    International Nuclear Information System (INIS)

    Toma, G.; Brancus, I.M.; Mitrica, B.; Sima, O.; Rebel, H.; Haungs, A.

    2005-01-01

    The study of primary cosmic rays with energies higher than 10 14 eV is done mostly by indirect observation techniques such as the study of Extensive Air Showers (EAS). In the much larger framework effort of inferring data on the mass and energy of the primaries from EAS observables, the present study aims at developing a versatile method and software tool that will be used to reconstruct lateral particle densities from the energy deposits of particles in the KASCADE-Grande detector stations. The study has been performed on simulated events, by taking into account the interaction of the EAS components with the detector array (energy deposits). The energy deposits have been simulated using the GEANT code and then the energy deposits have been parametrized for different incident energies and angles of EAS particles. Thus the results obtained for simulated events have the same level of consistency as the experimental data. This technique will allow an increased speed of lateral particle density reconstruction when studying real events detected by the KASCADE-Grande array. The particle densities in detectors have been reconstructed from the energy deposits. A correlation between lateral particle density and primary mass and primary energy (at ∼600 m from shower core) has been established. The study puts great emphasis on the quality of reconstruction and also on the speed of the technique. The data obtained from the study on simulated events creates the basis for the next stage of the study, the study of real events detected by the KASCADE-Grande array. (authors)

  2. The recruitment of patients to trials in head and neck cancer: a qualitative study of the EaStER trial of treatments for early laryngeal cancer.

    Science.gov (United States)

    Hamilton, D W; de Salis, I; Donovan, J L; Birchall, M

    2013-08-01

    We aimed to investigate the factors contributing to poor recruitment to the EaStER trial "Early Stage glottic cancer: Endoscopic excision or Radiotherapy" feasibility study. We performed a prospective qualitative assessment of the EaStER trial at three centres to investigate barriers to recruitment and implement changes. Methods used included semi-structured interviews, focus groups and audio-recordings of recruitment encounters. First, surgeons and recruiters did not all accept the primary outcome as the rationale for the trial. Surgeons did not always adhere to the trial eligibility criteria leading to variations between centres in the numbers of "eligible" patients. Second, as both treatments were considered equally successful, recruiters and patients focused on the pragmatics of the different trial arms, favouring surgery over radiotherapy. The lack of equipoise was reflected in the way recruiters presented trial information. Third, patient views, beliefs and preferences were not fully elicited or addressed by recruiters. Fourth, in some centres, logistical issues made trial participation difficult. This qualitative research identified several major issues that explained recruitment difficulties. While there was insufficient time to address these in the EaStER trial, several factors would need to be addressed to launch further RCTs in head and neck cancer. These include the need for clear ongoing agreement among recruiting clinicians regarding details in the study protocol; an understanding of the logistical issues hindering recruitment at individual centres; and training recruiters to enable them to explain the need for randomisation and the rationale for the RCT to patients.

  3. A comparison of genotyping-by-sequencing analysis methods on low-coverage crop datasets shows advantages of a new workflow, GB-eaSy.

    Science.gov (United States)

    Wickland, Daniel P; Battu, Gopal; Hudson, Karen A; Diers, Brian W; Hudson, Matthew E

    2017-12-28

    Genotyping-by-sequencing (GBS), a method to identify genetic variants and quickly genotype samples, reduces genome complexity by using restriction enzymes to divide the genome into fragments whose ends are sequenced on short-read sequencing platforms. While cost-effective, this method produces extensive missing data and requires complex bioinformatics analysis. GBS is most commonly used on crop plant genomes, and because crop plants have highly variable ploidy and repeat content, the performance of GBS analysis software can vary by target organism. Here we focus our analysis on soybean, a polyploid crop with a highly duplicated genome, relatively little public GBS data and few dedicated tools. We compared the performance of five GBS pipelines using low-coverage Illumina sequence data from three soybean populations. To address issues identified with existing methods, we developed GB-eaSy, a GBS bioinformatics workflow that incorporates widely used genomics tools, parallelization and automation to increase the accuracy and accessibility of GBS data analysis. Compared to other GBS pipelines, GB-eaSy rapidly and accurately identified the greatest number of SNPs, with SNP calls closely concordant with whole-genome sequencing of selected lines. Across all five GBS analysis platforms, SNP calls showed unexpectedly low convergence but generally high accuracy, indicating that the workflows arrived at largely complementary sets of valid SNP calls on the low-coverage data analyzed. We show that GB-eaSy is approximately as good as, or better than, other leading software solutions in the accuracy, yield and missing data fraction of variant calling, as tested on low-coverage genomic data from soybean. It also performs well relative to other solutions in terms of the run time and disk space required. In addition, GB-eaSy is built from existing open-source, modular software packages that are regularly updated and commonly used, making it straightforward to install and maintain

  4. A large sample of Kohonen selected E+A (post-starburst) galaxies from the Sloan Digital Sky Survey

    Science.gov (United States)

    Meusinger, H.; Brünecke, J.; Schalldach, P.; in der Au, A.

    2017-01-01

    the E+A sample that may indicate hidden AGNs, though other sources are also possible. The catalogue is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/597/A134

  5. A Reflight of the Explorer-1 Science Mission: The Montana EaRth Orbiting Pico Explorer (MEROPE)

    Science.gov (United States)

    Klumpar, D. M.; Obland, M.; Hunyadi, G.; Jepsen, S.; Larsen, B.; Kankelborg, C.; Hiscock, W.

    2001-05-01

    Montana State University's interdisciplinary Space Science and Engineering Laboratory (SSEL) under support from the Montana NASA Space Grant Consortium is engaged in an earth orbiting satellite student design and flight project. The Montana EaRth Orbiting Pico Explorer (MEROPE) will carry a modern-day reproduction of the scientific payload carried on Explorer-1. On February 1, 1958 the United States launched its first earth orbiting satellite carrying a 14 kg scientific experiment built by Professor James Van Allen's group at the State University of Iowa (now The University of Iowa). The MEROPE student satellite will carry a reproduction, using current-day technology, of the scientific payload flown on Explorer-1. The CubeSat-class satellite will use currently available, low cost technologies to produce a payload-carrying satellite with a total orbital mass of 1 kg in a volume of 1 cubic liter. The satellite is to be launched in late 2001 into a 600 km, 65° inclination orbit. MEROPE will utilize passive magnetic orientation for 2-axis attitude control. A central microprocessor provides timing, controls on-board operations and switching, and enables data storage. Body mounted GaAs solar arrays are expected to provide in excess of 1.5 W. to maintain battery charge and operate the bus and payload. The Geiger counter will be operated at approximately 50% duty cycle, primarily during transits of the earth's radiation belts. Data will be stored on board and transmitted approximately twice per day to a ground station located on the Bozeman campus of the Montana State University. Owing to the 65° inclination, the instrument will also detect the higher energy portion of the electron spectrum responsible for the production of the Aurora Borealis. This paper describes both the technical implementation and design of the satellite and its payload as well as the not inconsiderable task of large team organization and management. As of March 2001, the student team consists of

  6. Global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa based on atmospheric observations

    Science.gov (United States)

    Vollmer, M. K.; Miller, B. R.; Rigby, M. L.; Reimann, S.; Muhle, J.; Agage, Soge, Snu Members, Kopri Members

    2010-12-01

    We report on the atmospheric measurements and global emissions of the hydrofluorocarbons (HFCs) HFC-365mfc (CH3CH2CF2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). These measurements are from in-situ observations at stations of AGAGE (Advanced Global Atmospheric Gases Experiment) and SOGE (System for Observations of Halogenated Greenhouse Gases in Europe), and from the Korean station Gosan. We also report on flask sample measurements from the Antarctic stations King Sejong and Troll, and extend our records back to the 1970s using archived air samples of both hemispheres. All data are used in a global 12-box 2-dimensional atmospheric transport model to derive global abundances and emission estimates. All four HFCs have strongly increased in the atmosphere in recent years with growth rates at nearly 10 %, resulting in dry air mole fractions at the end of 2009 of 0.49 ppt for HFC-365mfc, 1.00 ppt for HFC-245fa, and 0.51 ppt for HFC-227ea. HFC-236fa, for which we report the first atmospheric measurements, is less abundant and has grown to 0.069 ppt at the end of 2009. Our model results show rapidly growing emissions of HFC-365mfc and HFC-245fa after 2002 but surprisingly these have now started to decline to globally 2.7 kt/yr (HFC-365mfc) and 6.1 kt/yr (HFC-245fa). On the other hand HFC-227ea and HFC-236fa show uninterrupted growth in their emissions of 2.5 kt/yr and 0.2 kt/yr at the end of 2009.

  7. Preliminary Results Regarding the Present Morphometric Characters of Thermal Rudd, Scardinius racovitzai Müller 1958 from Pețea Spring Natural Reserve

    Directory of Open Access Journals (Sweden)

    Grigoraş Gabriela

    2015-12-01

    Full Text Available The precarious temperature regime, associated with the negative influence of other environmental and biotic factors, represents a major risk for the survival of the thermal rudd from the lake Ochiul Mare, located in the Pârâul Peţea natural reserve. Therefore, a complex morphometric and body geometry analysis was conducted on specimens collected in 2013 in order to define the variability of the present population. The relatively small sample size is due to legislative restrictions on collecting endangered species, so statistical methods of analysis were applied to increase confidence in the assertions.

  8. Study of the decay of hot nuclear systems formed in Au-induced reactions at E/A=60 MeV

    International Nuclear Information System (INIS)

    Delis, D.N.; Colonna, N.; Sui, Q.; Tso, K.

    1993-01-01

    Multifragment production was measured for the 197 Au + 12 C, 27 Al, 51 V, 63 Cu and 197 Au reactions at E/A= 60 MeV. Comparison of experimental observables to calculations with a dynamical code coupled to a statistical model indicates agreement with some features of the experimental data. Furthermore the logarithms of the branching ratios for binary, ternary, quaternary, and quinary decays plotted as a function of E -1/2 show a linear dependence that ,strongly suggests a statistical competition between the various multifraigment channels. Finally, by utilizing the momentum tensor, the shape of the most central events in momentum space has been determined

  9. Decay patterns of target-like and projectile-like nuclei in 84Kr+197Au, natU reactions at E/A=150 MeV

    International Nuclear Information System (INIS)

    Quednau, B.M.; Galin, J.; Ledoux, X.; Crema, E.; Gebauer, B.; Hilscher, D.; Jahnke, U.; Jacquet, D.; Leray, S.; and others.

    1996-01-01

    The reactions 84 Kr+ 197 Au and 84 Kr+ nat U were studied at E/A=150 MeV employing the large-volume neutron multiplicity filter ORION at SATURNE. The observed correlations between the atomic number of projectile-like nuclei and neutron multiplicity indicate large excitation energies in the primary projectile- and target-like fragments. Angular correlations between the fission fragments of the U-like nucleus and the projectile-like fragments show a memory of the reaction plane, however no indications of spin effects are found. (author)

  10. Representaciones culturales de países hispanohablantes: una mirada a los recursos visuales en el contexto de EaD

    Directory of Open Access Journals (Sweden)

    Leandra Cristina de Oliveira

    2017-09-01

    Full Text Available Con vistas a la relevancia de la discusión sobre cultura en la Lingüística Aplicada, tanto en el ámbito de la enseñanza de lengua materna como de lengua extranjera, direccionamos el diálogo sobre el tema a la enseñanza de español en la Educación a Distancia (EaD. Observando el Curso de Letras Español de la Universidad Federal de Santa Catarina, en la modalidad EaD, objetivamos discutir las representaciones culturales de los países hispanohablantes en las imágenes del Ambiente virtual de la asignatura Lengua Española I. Consonante al objetivo, asentamos la siguiente cuestión: ¿en qué medida las representaciones culturales en las imágenes analizadas contribuyen para la desconstrucción de concepciones reduccionistas y estereotipadas sobre los países hispanohablantes? La respuesta a esta cuestión procede del análisis de las imágenes introductorias de los tópicos de la asignatura citada, fundamentada en bases teóricas de estudios culturales, con especial atención a los conceptos de cultura, identidad y diferencia.

  11. High-precision determination of 18O/16O ratios of silver phosphate by EA-pyrolysis-IRMS continuous flow technique.

    Science.gov (United States)

    Lécuyer, Christophe; Fourel, François; Martineau, François; Amiot, Romain; Bernard, Aurélien; Daux, Valérie; Escarguel, Gilles; Morrison, John

    2007-01-01

    A high-precision, and rapid on-line method for oxygen isotope analysis of silver phosphate is presented. The technique uses high-temperature elemental analyzer (EA)-pyrolysis interfaced in continuous flow (CF) mode to an isotopic ratio mass spectrometer (IRMS). Calibration curves were generated by synthesizing silver phosphate with a 13 per thousand spread in delta(18)O values. Calibration materials were obtained by reacting dissolved potassium dihydrogen phosphate (KH(2)PO(4)) with water samples of various oxygen isotope compositions at 373 K. Validity of the method was tested by comparing the on-line results with those obtained by classical off-line sample preparation and dual inlet isotope measurement. In addition, silver phosphate precipitates were prepared from a collection of biogenic apatites with known delta(18)O values ranging from 12.8 to 29.9 per thousand (V-SMOW). Reproducibility of +/- 0.2 per thousand was obtained by the EA-Py-CF-IRMS method for sample sizes in the range 400-500 microg. Both natural and synthetic samples are remarkably well correlated with conventional (18)O/(16)O determinations. Silver phosphate is a very stable material and easy to degas and, thus, could be considered as a good candidate to become a reference material for the determination of (18)O/(16)O ratios of phosphate by high-temperature pyrolysis. Copyright 2006 John Wiley & Sons, Ltd.

  12. Carbon-13 composition of bulk dry wines by irm-EA/MS and irm-13C NMR: An indicator of vine water status

    Directory of Open Access Journals (Sweden)

    Guyon Francois

    2017-01-01

    Full Text Available Measurements performed on a set of 32 authentic wines (not submitted to any oenological treatment and their ethanol, recovered by distillation, show high correlation between δ13C of bulk wine and its ethanol. These measurements were performed by isotope ratio monitoring by mass spectrometry coupled to an elemental analyzer (irm-EA/MS. Then a series of wines produced by vines of which water status was assessed during the growing season with predawn leaf water potential measurements, was studied by irm-EA/MS. As expected δ13C is correlated to vine water status conditions, as a result of stomatal closure. The ethanol of these specific wines was also analyzed by isotope ratio monitoring and by nuclear magnetic resonance (irm-13C NMR to determine carbon-13 composition on the two specific sites of the ethanol skeleton. If these measurements confirm the correlation between 13C composition and vine growth conditions, the 13C stereospecific information does not make vine water status assessment more precise.

  13. A retrospective analysis of real-world use of the eaTracker® My Goals website by adults from Ontario and Alberta, Canada.

    Science.gov (United States)

    Lieffers, Jessica R L; Haresign, Helen; Mehling, Christine; Hanning, Rhona M

    2016-09-15

    Little is known about use of goal setting and tracking tools within online programs to support nutrition and physical activity behaviour change. In 2011, Dietitians of Canada added "My Goals," a nutrition and physical activity behaviour goal setting and tracking tool to their free publicly available self-monitoring website (eaTracker® ( http://www.eaTracker.ca/ )). My Goals allows users to: a) set "ready-made" SMART (Specific, Measurable, Attainable, Realistic, Time-related) goals (choice of n = 87 goals from n = 13 categories) or "write your own" goals, and b) track progress using the "My Goals Tracker." The purpose of this study was to characterize: a) My Goals user demographics, b) types of goals set, and c) My Goals Tracker use. Anonymous data on all goals set using the My Goals feature from December 6/2012-April 28/2014 by users ≥19y from Ontario and Alberta, Canada were obtained. This dataset contained: anonymous self-reported user demographic data, user set goals, and My Goals Tracker use data. Write your own goals were categorized by topic and specificity. Data were summarized using descriptive statistics. Multivariate binary logistic regression was used to determine associations between user demographics and a) goal topic areas and b) My Goals Tracker use. Overall, n = 16,511 goal statements (75.4 % ready-made; 24.6 % write your own) set by n = 8,067 adult users 19-85y (83.3 % female; mean age 41.1 ± 15.0y, mean BMI 28.8 ± 7.6kg/m(2)) were included for analysis. Overall, 33.1 % of ready-made goals were from the "Managing your Weight" category. Of write your own goal entries, 42.3 % were solely distal goals (most related to weight management); 38.6 % addressed nutrition behaviour change (16.6 % had unspecific general eating goals); 18.1 % addressed physical activity behaviour change (47.3 % had goals without information on exercise amount and type). Many write your own goals were poor quality (e.g., non-specific (e.g., missing

  14. Atmospheric histories and global emissions of the anthropogenic hydrofluorocarbons HFC-365mfc, HFC-245fa, HFC-227ea, and HFC-236fa

    Science.gov (United States)

    Vollmer, Martin K.; Miller, Benjamin R.; Rigby, Matthew; Reimann, Stefan; Mühle, Jens; Krummel, Paul B.; O'Doherty, Simon; Kim, Jooil; Rhee, Tae Siek; Weiss, Ray F.; Fraser, Paul J.; Simmonds, Peter G.; Salameh, Peter K.; Harth, Christina M.; Wang, Ray H. J.; Steele, L. Paul; Young, Dickon; Lunder, Chris R.; Hermansen, Ove; Ivy, Diane; Arnold, Tim; Schmidbauer, Norbert; Kim, Kyung-Ryul; Greally, Brian R.; Hill, Matthias; Leist, Michael; Wenger, Angelina; Prinn, Ronald G.

    2011-04-01

    We report on ground-based atmospheric measurements and emission estimates of the four anthropogenic hydrofluorocarbons (HFCs) HFC-365mfc (CH3CF2CH2CF3, 1,1,1,3,3-pentafluorobutane), HFC-245fa (CHF2CH2CF3, 1,1,1,3,3-pentafluoropropane), HFC-227ea (CF3CHFCF3, 1,1,1,2,3,3,3-heptafluoropropane), and HFC-236fa (CF3CH2CF3, 1,1,1,3,3,3-hexafluoropropane). In situ measurements are from the global monitoring sites of the Advanced Global Atmospheric Gases Experiment (AGAGE), the System for Observations of Halogenated Greenhouse Gases in Europe (SOGE), and Gosan (South Korea). We include the first halocarbon flask sample measurements from the Antarctic research stations King Sejong and Troll. We also present measurements of archived air samples from both hemispheres back to the 1970s. We use a two-dimensional atmospheric transport model to simulate global atmospheric abundances and to estimate global emissions. HFC-365mfc and HFC-245fa first appeared in the atmosphere only ˜1 decade ago; they have grown rapidly to globally averaged dry air mole fractions of 0.53 ppt (in parts per trillion, 10-12) and 1.1 ppt, respectively, by the end of 2010. In contrast, HFC-227ea first appeared in the global atmosphere in the 1980s and has since grown to ˜0.58 ppt. We report the first measurements of HFC-236fa in the atmosphere. This long-lived compound was present in the atmosphere at only 0.074 ppt in 2010. All four substances exhibit yearly growth rates of >8% yr-1 at the end of 2010. We find rapidly increasing emissions for the foam-blowing compounds HFC-365mfc and HFC-245fa starting in ˜2002. After peaking in 2006 (HFC-365mfc: 3.2 kt yr-1, HFC-245fa: 6.5 kt yr-1), emissions began to decline. Our results for these two compounds suggest that recent estimates from long-term projections (to the late 21st century) have strongly overestimated emissions for the early years of the projections (˜2005-2010). Global HFC-227ea and HFC-236fa emissions have grown to average values of 2.4 kt yr-1

  15. Testing of an automated online EA-IRMS method for fast and simultaneous carbon content and stable isotope measurement of aerosol samples

    Science.gov (United States)

    Major, István; Gyökös, Brigitta; Túri, Marianna; Futó, István; Filep, Ágnes; Hoffer, András; Molnár, Mihály

    2016-04-01

    Comprehensive atmospheric studies have demonstrated that carbonaceous aerosol is one of the main components of atmospheric particulate matter over Europe. Various methods, considering optical or thermal properties, have been developed for quantification of the accurate amount of both organic and elemental carbon constituents of atmospheric aerosol. The aim of our work was to develop an alternative fast and easy method for determination of the total carbon content of individual aerosol samples collected on prebaked quartz filters whereby the mass and surface concentration becomes simply computable. We applied the conventional "elemental analyzer (EA) coupled online with an isotope ratio mass spectrometer (IRMS)" technique which is ubiquitously used in mass spectrometry. Using this technique we are able to measure simultaneously the carbon stable isotope ratio of the samples, as well. During the developing process, we compared the EA-IRMS technique with an off-line catalytic combustion method worked out previously at Hertelendi Laboratory of Environmental Studies (HEKAL). We tested the combined online total carbon content and stable isotope ratio measurement both on standard materials and real aerosol samples. Regarding the test results the novel method assures, on the one hand, at least 95% of carbon recovery yield in a broad total carbon mass range (between 100 and 3000 ug) and, on the other hand, a good reproducibility of stable isotope measurements with an uncertainty of ± 0.2 per mill. Comparing the total carbon results obtained by the EA-IRMS and the off-line catalytic combustion method we found a very good correlation (R2=0.94) that proves the applicability of both preparation method. Advantages of the novel method are the fast and simplified sample preparation steps and the fully automated, simultaneous carbon stable isotope ratio measurement processes. Furthermore stable isotope ratio results can effectively be applied in the source apportionment

  16. Influence of wind on aerodynamic drag for the second case of the arrangement of the equipment on the LE 060EA locomotive bodywork

    Directory of Open Access Journals (Sweden)

    Sorin ARSENE

    2015-06-01

    Full Text Available The electric power supply equipment of electric railways vehicles of surface is placed on the their body. The arrangement of the equipment on the vehicle body determines the variation of the aerodynamic drag. The gusts of wind occurring during the vehicle movement result in additional requests. The case of the locomotive of type LE 060 EA 5100kW moving with the second driving position is analyzed in this paper. For this particular case the components ensemble of the power supply system was geometric modelled in 3D format at 1:1 scale. The resulted model was placed in air flow simulation software to determine the aerodynamic resistance. The wind influence is analyzed for five point values of its speed. The wind direction is simulated by eight point values of the angle that it makes to the longitudinal axis of the vehicle.

  17. A simulation study of Linsley's approach to infer elongation rate and fluctuations of the EAS maximum depth from muon arrival time distributions

    International Nuclear Information System (INIS)

    Badea, A.F.; Brancus, I.M.; Rebel, H.; Haungs, A.; Oehlschlaeger, J.; Zazyan, M.

    1999-01-01

    The average depth of the maximum X m of the EAS (Extensive Air Shower) development depends on the energy E 0 and the mass of the primary particle, and its dependence from the energy is traditionally expressed by the so-called elongation rate D e defined as change in the average depth of the maximum per decade of E 0 i.e. D e = dX m /dlog 10 E 0 . Invoking the superposition model approximation i.e. assuming that a heavy primary (A) has the same shower elongation rate like a proton, but scaled with energies E 0 /A, one can write X m = X init + D e log 10 (E 0 /A). In 1977 an indirect approach studying D e has been suggested by Linsley. This approach can be applied to shower parameters which do not depend explicitly on the energy of the primary particle, but do depend on the depth of observation X and on the depth X m of shower maximum. The distribution of the EAS muon arrival times, measured at a certain observation level relatively to the arrival time of the shower core reflect the pathlength distribution of the muon travel from locus of production (near the axis) to the observation locus. The basic a priori assumption is that we can associate the mean value or median T of the time distribution to the height of the EAS maximum X m , and that we can express T = f(X,X m ). In order to derive from the energy variation of the arrival time quantities information about elongation rate, some knowledge is required about F i.e. F = - ∂ T/∂X m ) X /∂(T/∂X) X m , in addition to the variations with the depth of observation and the zenith-angle (θ) dependence, respectively. Thus ∂T/∂log 10 E 0 | X = - F·D e ·1/X v ·∂T/∂secθ| E 0 . In a similar way the fluctuations σ(X m ) of X m may be related to the fluctuations σ(T) of T i.e. σ(T) = - σ(X m )· F σ ·1/X v ·∂T/∂secθ| E 0 , with F σ being the corresponding scaling factor for the fluctuation of F. By simulations of the EAS development using the Monte Carlo code CORSIKA the energy and angle

  18. Implication of EAS data for the study of primary cosmic rays above 10 to the 5th power GeV

    Science.gov (United States)

    Popova, L.; Wdowczyk, J.

    1985-01-01

    Due to the strong decrease of the energetic cosmic ray flux its direct detection at the top of atmosphere with aircraft is limited at the present time to about 100,000 GeV. The intensity of all primary particles can be approximated in the range 100 to 100,000 GeV by power function with power index 2.65. There are predominantly protons and the rest is represented by several groups of nuclei. In the range of 100,000 to 10 to the 8th power GeV considerable disagreement is most probably connected with the uncertainity of the indirect derivation of the parameters of extensive air showers. Results for the primary spectrum in the range to the 8th power GeV, obtained by implication of extensive air showers (EAS) data from mountain altitudes are discussed.

  19. Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responses.

    Directory of Open Access Journals (Sweden)

    Nathaniel J Schuldt

    Full Text Available Malaria greatly impacts the health and wellbeing of over half of the world's population. Promising malaria vaccine candidates have attempted to induce adaptive immune responses to Circumsporozoite (CS protein. Despite the inclusion of potent adjuvants, these vaccines have limited protective efficacy. Conventional recombinant adenovirus (rAd based vaccines expressing CS protein can induce CS protein specific immune responses, but these are essentially equivalent to those generated after use of the CS protein subunit based vaccines. In this study we combined the use of rAds expressing CS protein along with rAds expressing novel innate immune response modulating proteins in an attempt to significantly improve the induction of CS protein specific cell mediated immune (CMI responses.BALB/cJ mice were co-vaccinated with a rAd vectors expressing CS protein simultaneous with a rAd expressing either TLR agonist (rEA or SLAM receptors adaptor protein (EAT-2. Paradoxically, expression of the TLR agonist uncovered a potent immunosuppressive activity inherent to the combined expression of the CS protein and rEA. Fortunately, use of the rAd vaccine expressing EAT-2 circumvented CS protein's suppressive activity, and generated a fivefold increase in the number of CS protein responsive, IFNγ secreting splenocytes, as well as increased the breadth of T cells responsive to peptides present in the CS protein. These improvements were positively correlated with the induction of a fourfold improvement in CS protein specific CTL functional activity in vivo.Our results emphasize the need for caution when incorporating CS protein into malaria vaccine platforms expressing or containing other immunostimulatory compounds, as the immunological outcomes may be unanticipated and/or counter-productive. However, expressing the SLAM receptors derived signaling adaptor EAT-2 at the same time of vaccination with CS protein can overcome these concerns, as well as significantly

  20. Search for EAS radio-emission at the Tien-Shan shower installation at a height of 3340 m above sea level

    Science.gov (United States)

    Beisenova, A.; Boos, E.; Haungs, A.; Sadykov, T.; Salihov, N.; Shepetov, A.; Tautayev, Y.; Vildanova, L.; Zhukov, V.

    2017-06-01

    The complex EAS installation of the Tien Shan mountain cosmic ray station which is situated at a height of 3340 m above sea level includes the scintillation and Cherenkov detectors of charged shower particles, an ionization calorimeter and a set of neutron detectors for registering the hadronic component of the shower, and a number of underground detectors of the penetrative EAS component. Now it is intended to expand this installation with a promising method for detecting the radio-emission generated by the particles of the developing shower. The facility for radio-emission detection consists of a three crossed dipole antennae, one being set vertically, and another two - mutually perpendicularly in a horizontal plane, all of them being connected to a three-channel radio-frequency amplifier of German production. By the passage of an extensive air shower, which is defined by a scintillation shower detector system, the output signal of antenna amplifier is digitized by a fast multichannel DT5720 ADC of Italian production, and kept within computer memory. The further analysis of the detected signal anticipates its operation according to a special algorithm and a search for the pulse of radio-emission from the shower. A functional test of the radio-installation is made with artificial signals which imitate those of the shower, and with the use of a N1996A type wave analyzer of Agilent Technologies production. We present preliminary results on the registration of extensive air shower emission at the Tien Shan installation which were collected during test measurements held in Summer 2016.

  1. Análise da utilização das tecnologias da informação e comunicação na educação a distância (EaD.

    Directory of Open Access Journals (Sweden)

    Carla Simone Pires

    2017-02-01

    Full Text Available A EaD se caracteriza por docentes e discentes fisicamente separados, conectados por TICs. No Brasil a EaD não é recente, entretanto, tem aumentado nos últimos anos devido a políticas públicas e à evolução das TICs, entretanto, a sua aplicação normalmente tem foco na economia de recursos. Apesar das dificuldades encontradas, é tendência mundial e converge para o uso de tecnologias. Neste sentido, TICs podem causar inclusão/exclusão social, dependendo de como sua utilização é planejadas. O mesmo ocorre com processos avaliativos, que mostram fragilidades. Os resultados permitem concluir que a transição para EaD não apresenta mudanças de práticas pedagógicas. Apesar disto, tem importante papel social, uma vez que vem suprir demandas reprimidas no que tange o acesso à educação superior, além de incentivar o desenvolvimento de municípios com Baixos Índice de Desenvolvimento Humano (IDH e Índice de Desenvolvimento da Educação Básica (IDEB. Ainda, mostra a necessidade de redimensionar as práticas de ensino (reinventando usos para TICs na transição entre ensino presencial e EaD, possibilitando que a EaD assuma sua função social na educação brasileira. Neste sentido,  Este trabalho teve como objetivo fazer um estudo analítico do contexto da Educação a Distância (EaD no Brasil, as práticas pedagógicas usadas e o papel das Tecnologias de Informação (TICs neste processo.

  2. Mass yield distributions for the reactions Ca+Ca, Nb+Nb and Ca+Ca at E/A=800 MeV in the molecular-dynamical model

    International Nuclear Information System (INIS)

    Kiselev, S.M.

    1987-01-01

    Mass yield distributions obtained on the basis of the molecular-dynamical model are presented for the Ca+Ca, Nb+Nb reactions at E/A=400 MeV and Ca+Ca reaction at E/A=800 MeV. For the fragments with masses upto quarter of the mass of initial nucleus the model predicts a power law for mass spectra with almost the same value of the exponent. Such the behaviour is roughly a result of the superposition of the fireball breakup and the disintegration of spectator regions rather than the evidence of a liquid-gas-like phase transition in hot nuclear matter

  3. Final Environmental Assessment (EA) for Modification of Airspace Units R-3008A/B/C from Visual Flight Rules (VFR) to VFR-Instrument Flight Rules (IFR) at Moody Air Force Base, Georgia

    Science.gov (United States)

    2015-09-30

    RULES ( IFR ) AT MOODY AIR FORCE BASE, GEORGIA September 2015 Finding of No Significant Impact Modification of Airspace Units R-3008A/B/C from...Interactions with Federally- Recognized Tribes. These tribal governments were also consulted regarding impacts to Final EA for VFR- IFR in R-3008A/B/C at Moody...analysis would focus on impacts to these Final EA for VFR- IFR in R-3008A/B/C at Moody AFB September 2015 2-5 resources from proposed activities

  4. Limites e possibilidades do ensino à distância (EaD na educação permanente em saúde: revisão integrativa

    Directory of Open Access Journals (Sweden)

    Adriane das Neves Silva

    2015-04-01

    Full Text Available Trata-se de um estudo sobre o uso do ensino a distância (EaD como uma estratégia de ensino na educação permanente em saúde (EPS, que teve como objetivo identificar e analisar os limites e possibilidades do uso da EaD na EPS. Estudo de revisão integrativa. O resultado aponta que a EaD é uma estratégia inovadora possível e potencial para a EPS, facilitando o desenvolvimento da aprendizagem dentro ou fora da instituição de saúde, porém é evidente a escassez de pesquisas na área. As limitações para a realização dos programas estão relacionadas à variável tempo, preparação para lidar com as tecnologias e importância do tutor como facilitador da aprendizagem. Conclui-se que o uso da EaD tem tido uma importante contribuição para o desenvolvimento dos recursos humanos em saúde, seja no processo de formação e/ou no processo contínuo de conhecimento.

  5. A retrospective analysis of real-world use of the eaTracker® My Goals website by adults from Ontario and Alberta, Canada

    Directory of Open Access Journals (Sweden)

    Jessica R. L. Lieffers

    2016-09-01

    Full Text Available Abstract Background Little is known about use of goal setting and tracking tools within online programs to support nutrition and physical activity behaviour change. In 2011, Dietitians of Canada added “My Goals,” a nutrition and physical activity behaviour goal setting and tracking tool to their free publicly available self-monitoring website (eaTracker® ( http://www.eaTracker.ca/ . My Goals allows users to: a set “ready-made” SMART (Specific, Measurable, Attainable, Realistic, Time-related goals (choice of n = 87 goals from n = 13 categories or “write your own” goals, and b track progress using the “My Goals Tracker.” The purpose of this study was to characterize: a My Goals user demographics, b types of goals set, and c My Goals Tracker use. Methods Anonymous data on all goals set using the My Goals feature from December 6/2012-April 28/2014 by users ≥19y from Ontario and Alberta, Canada were obtained. This dataset contained: anonymous self-reported user demographic data, user set goals, and My Goals Tracker use data. Write your own goals were categorized by topic and specificity. Data were summarized using descriptive statistics. Multivariate binary logistic regression was used to determine associations between user demographics and a goal topic areas and b My Goals Tracker use. Results Overall, n = 16,511 goal statements (75.4 % ready-made; 24.6 % write your own set by n = 8,067 adult users 19-85y (83.3 % female; mean age 41.1 ± 15.0y, mean BMI 28.8 ± 7.6kg/m2 were included for analysis. Overall, 33.1 % of ready-made goals were from the “Managing your Weight” category. Of write your own goal entries, 42.3 % were solely distal goals (most related to weight management; 38.6 % addressed nutrition behaviour change (16.6 % had unspecific general eating goals; 18.1 % addressed physical activity behaviour change (47.3 % had goals without information on exercise amount and type. Many write your own

  6. Optimization of on-line hydrogen stable isotope ratio measurements of halogen- and sulfur-bearing organic compounds using elemental analyzer-chromium/high-temperature conversion isotope ratio mass spectrometry (EA-Cr/HTC-IRMS).

    Science.gov (United States)

    Gehre, Matthias; Renpenning, Julian; Geilmann, Heike; Qi, Haiping; Coplen, Tyler B; Kümmel, Steffen; Ivdra, Natalija; Brand, Willi A; Schimmelmann, Arndt

    2017-03-30

    Accurate hydrogen isotopic analysis of halogen- and sulfur-bearing organics has not been possible with traditional high-temperature conversion (HTC) because the formation of hydrogen-bearing reaction products other than molecular hydrogen (H 2 ) is responsible for non-quantitative H 2 yields and possible hydrogen isotopic fractionation. Our previously introduced, new chromium-based EA-Cr/HTC-IRMS (Elemental Analyzer-Chromium/High-Temperature Conversion Isotope Ratio Mass Spectrometry) technique focused primarily on nitrogen-bearing compounds. Several technical and analytical issues concerning halogen- and sulfur-bearing samples, however, remained unresolved and required further refinement of the reactor systems. The EA-Cr/HTC reactor was substantially modified for the conversion of halogen- and sulfur-bearing samples. The performance of the novel conversion setup for solid and liquid samples was monitored and optimized using a simultaneously operating dual-detection system of IRMS and ion trap MS. The method with several variants in the reactor, including the addition of manganese metal chips, was evaluated in three laboratories using EA-Cr/HTC-IRMS (on-line method) and compared with traditional uranium-reduction-based conversion combined with manual dual-inlet IRMS analysis (off-line method) in one laboratory. The modified EA-Cr/HTC reactor setup showed an overall H 2 -recovery of more than 96% for all halogen- and sulfur-bearing organic compounds. All results were successfully normalized via two-point calibration with VSMOW-SLAP reference waters. Precise and accurate hydrogen isotopic analysis was achieved for a variety of organics containing F-, Cl-, Br-, I-, and S-bearing heteroelements. The robust nature of the on-line EA-Cr/HTC technique was demonstrated by a series of 196 consecutive measurements with a single reactor filling. The optimized EA-Cr/HTC reactor design can be implemented in existing analytical equipment using commercially available material and

  7. Capacidades do Estado brasileiro e arquitetura institucional da EaD: da organização burocrática à autonomia inserida dos órgãos estatais

    Directory of Open Access Journals (Sweden)

    Daniela da Costa Britto Pereira Lima

    2018-04-01

    Full Text Available Resumo: O tema deste estudo é a arquitetura institucional da educação a distância (EaD no Brasil sob a ótica das capacidades do Estado no que se refere à organização burocrática. Seu objetivo geral é apresentar e discutir algumas das capacidades do Estado brasileiro para gerir sua política pública de EaD. A pesquisa é do tipo bibliográfica e de natureza empírica, com suporte teórico em Evans (1993, 1995, 2004. O estudo empírico considerou o mapeamento e a análise da arquitetura institucional da EaD no Brasil entre 2010 e 2013 (LIMA, 2013. Constata-se que o Estado precisa rever sua arquitetura institucional da EaD, visando desenvolver a sua capacidade de organização burocrática e autonomia inserida, para passar de um Estado intermediário para desenvolvimentista. Palavras-chave: Educação a distância; educação superior; capacidades do Estado; arquitetura institucional.   Abstract: The theme of this study is the institutional architecture of distance education - EaD - in Brazil, from the point of view of the state's capabilities, regarding the bureaucratic organization. Its general objective is to present and discuss some of the capabilities of the Brazilian State to manage it's public DE policy. The research is a bibliographical and empirical study, with theoretical support in Evans (1993, 1995, 2004. The empirical study considered the mapping and analysis of the institutional architecture of EaD in Brazil between 2010 and 2013 (LIMA, 2013. It concludes that the Brazilian State needs to reassess its DE institutional architecture as a means to develop its bureaucratic organization capacity and inserted autonomy, and as a condition to move from an intermediary State to a developed one. Keywords: distance education; higher education; State capacity; institutional architecture.   Resumen: El tema de este estudio es la arquitectura institucional de la educación a distancia (EaD en Brasil bajo la óptica de las capacidades

  8. Search for $E_{\\gamma} \\geq 5 x 10^{13} eV \\gamma$-Ray Through the BAKSAN and EAS-TOP Correlated Data

    CERN Document Server

    Aglietta, M

    2000-01-01

    A search for transient point sources of ultra-high-energy (UHE) \\gamma-rays has been performed, based on the correlation of two extensive air shower arrays, BAKSAN (North Caucasus, $1700 m$ a.s.l., BAKSAN Neutrino Observatory, $9 Russia) and EAS-TOP (Campo Imperatore, $2005$ a.s.l., Laboratori Nazionali del Gran Sasso, Italy), which are located at very similar latitudes $(\\phi\\approx 43\\dag N)$, and separated in longitude by $\\Delta\\lambda \\approx 33.7\\dag$. $9 The search has been conducted at primary energy $E_{\\gamma} \\geq 5\\cdot10^{13} eV$ on the timescale of a daily source transit over the sky observable in the northern hemisphere $(19\\dag 5 \\cdot 10^{13} eV)> 2.0 \\cdot10^{-11} cm^{-2} s^{-1}$ and duration $\\Delta t 5. \\cdot 10^{13} eV) > 1.3 \\cdot10^{-11} cm^{-2} s^{-}1$ and $\\Delta t< 7.5 hrs$. A coincident $9 episode from Markarian $421$, observed on January 15th, 1994, with expected chance imitation rate $n_{ch}=0.01$ is discussed.

  9. Sitewide environmental assessment EA-1236 for preparation for transfer of ownership of Naval Petroleum Reserve No. 3 (NPR-3), Natrona County, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The Proposed Action includes the following principal elements: (1) The accelerated plugging and abandoning of uneconomic wells over the next six years. Uneconomic wells are operating wells which can no longer cover their direct and indirect costs. DOE estimates that there are 900 wells to be plugged and abandoned over the next six years, leaving approximately 200 wells for transfer by 2003. (2) Complete reclamation and restoration of abandoned sites. Restoration would include dismantling surface facilities, batteries, roads, test satellites, electrical distribution systems and associated power poles, when they are no longer needed for production. Soil contaminated by hydrocarbons would be biologically treated. Roads, facilities, batteries, and well sites would be ripped up, recontoured, disked and seeded with native vegetation. (3) The continued development of the Rocky Mountain Oilfield Testing Center (RMOTC) through the establishment of a consortium of university, state and private institutions. RMOTC would continue to provide facilities and support to government and private industry for testing and evaluating new oilfield and environmental technologies. Based on the findings of the EA, DOE has determined that the proposal does not constitute a major Federal action significantly affecting the quality of the human environment within the meaning of NEPA. Therefore, an environmental impact statement is not required.

  10. Sitewide environmental assessment EA-1236 for preparation for transfer of ownership of Naval Petroleum Reserve No. 3 (NPR-3), Natrona County, Wyoming

    International Nuclear Information System (INIS)

    1998-04-01

    The Proposed Action includes the following principal elements: (1) The accelerated plugging and abandoning of uneconomic wells over the next six years. Uneconomic wells are operating wells which can no longer cover their direct and indirect costs. DOE estimates that there are 900 wells to be plugged and abandoned over the next six years, leaving approximately 200 wells for transfer by 2003. (2) Complete reclamation and restoration of abandoned sites. Restoration would include dismantling surface facilities, batteries, roads, test satellites, electrical distribution systems and associated power poles, when they are no longer needed for production. Soil contaminated by hydrocarbons would be biologically treated. Roads, facilities, batteries, and well sites would be ripped up, recontoured, disked and seeded with native vegetation. (3) The continued development of the Rocky Mountain Oilfield Testing Center (RMOTC) through the establishment of a consortium of university, state and private institutions. RMOTC would continue to provide facilities and support to government and private industry for testing and evaluating new oilfield and environmental technologies. Based on the findings of the EA, DOE has determined that the proposal does not constitute a major Federal action significantly affecting the quality of the human environment within the meaning of NEPA. Therefore, an environmental impact statement is not required

  11. The important role of martensite laths to fracture toughness for the ductile fracture controlled by the strain in EA4T axle steel

    International Nuclear Information System (INIS)

    Liang, Yilong; Long, Shaolei; Xu, Pingwei; Lu, Yemao; Jiang, Yun; Liang, Yu; Yang, Ming

    2017-01-01

    The Hall-Petch relationship was used to investigate the role of martensite lath on fracture toughness (K IC ) during ductile fracture in a low-carbon EA4T axle steel. The hierarchical structures of lath martensite was clarified by means of optical microscope (OM), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and electron backscattering diffraction (EBSD). Firstly, in such hierarchical structures, packet size (d p ) and block size (d b ) increase significantly with the size of prior austenite (d r ), while the martensite lath width (d l ) decreases. Subsequently, K IC was measured and follows the Hall-Petch relationship with d l . It depends on the rotation, bending and direct shear during crack propagation of laths, confirmed by EBSD. Besides, fracture toughness (K IC ) is proportional to a parameter ε v , the matrix strain, which is related to the plastic deformation of laths. Therefore, the martensite lath in hierarchical structures is the effective control unit of K IC during ductile fracture controlled by the strain.

  12. Authenticity determination of honeys with non-extractable proteins by means of elemental analyzer (EA) and liquid chromatography (LC) coupled to isotope ratio mass spectroscopy (IRMS).

    Science.gov (United States)

    Dong, Hao; Xiao, Kaijun; Xian, Yanping; Wu, Yuluan

    2018-02-01

    The present work aims to systematically demonstrate the authenticity of honeys with non-extractable proteins for the first time, by means of EA-IRMS and LC-IRMS. Fifty-three pure honeys of various botanical and geographical origins were studied and a criterion on the basis of the stable carbon isotope ratio characterization of total honey and the main sugars was established for pure honeys. Parameters such as δ 13 C values of total honey and the main sugars were well utilized to identify honeys with non-extractable proteins. Thirty-five honeys from which protein could not be extracted were all identified as adulterated with C-4 sugars or C-3 sugars. The use of isotopic compositions and some systematic differences permit the honeys with non-extractable proteins to be reliably identified. The findings obtained in this work could supplement the AOAC 998.12 C-4 sugar method, with regard to honeys from which protein cannot be extracted. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. The important role of martensite laths to fracture toughness for the ductile fracture controlled by the strain in EA4T axle steel

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Yilong, E-mail: liangyilong@126.com [College of Materials Science and Metallurgical Engineering, Guizhou University (China); Guizhou key Laboratory for Mechanical Behavior and Microstructure of Materials (China); National & Local Joint Engineering Laboratory for High-performance Metal Structure Material and Advanced Manufacturing Technology (China); Long, Shaolei; Xu, Pingwei; Lu, Yemao [College of Materials Science and Metallurgical Engineering, Guizhou University (China); Guizhou key Laboratory for Mechanical Behavior and Microstructure of Materials (China); National & Local Joint Engineering Laboratory for High-performance Metal Structure Material and Advanced Manufacturing Technology (China); Jiang, Yun [Guizhou key Laboratory for Mechanical Behavior and Microstructure of Materials (China); National & Local Joint Engineering Laboratory for High-performance Metal Structure Material and Advanced Manufacturing Technology (China); Liang, Yu; Yang, Ming [College of Materials Science and Metallurgical Engineering, Guizhou University (China); Guizhou key Laboratory for Mechanical Behavior and Microstructure of Materials (China); National & Local Joint Engineering Laboratory for High-performance Metal Structure Material and Advanced Manufacturing Technology (China)

    2017-05-17

    The Hall-Petch relationship was used to investigate the role of martensite lath on fracture toughness (K{sub IC}) during ductile fracture in a low-carbon EA4T axle steel. The hierarchical structures of lath martensite was clarified by means of optical microscope (OM), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and electron backscattering diffraction (EBSD). Firstly, in such hierarchical structures, packet size (d{sub p}) and block size (d{sub b}) increase significantly with the size of prior austenite (d{sub r}), while the martensite lath width (d{sub l}) decreases. Subsequently, K{sub IC} was measured and follows the Hall-Petch relationship with d{sub l}. It depends on the rotation, bending and direct shear during crack propagation of laths, confirmed by EBSD. Besides, fracture toughness (K{sub IC}) is proportional to a parameter ε{sub v}, the matrix strain, which is related to the plastic deformation of laths. Therefore, the martensite lath in hierarchical structures is the effective control unit of K{sub IC} during ductile fracture controlled by the strain.

  14. EA 18G Growler Aircraft (EA 18G)

    Science.gov (United States)

    2015-12-01

    10051.9 N/A 13186.9 8636.4 11550.1 15672.4 1 APB Breach Confidence Level Confidence Level of cost estimate for current APB: 50% The current...estimate recommendation aims to provide sufficient resources to execute the program under normal conditions, encountering average levels of technical...TY $M) Initial PAUC Development Estimate Changes PAUC Production Estimate Econ Qty Sch Eng Est Oth Spt Total 93.573 4.150 1.442 -0.319 0.947 -0.348

  15. Ensino da oralidade em Língua Estrangeira na EaD através de programas de comunicação síncrona. L2 speech teaching in Distance Education (EaD through synchronous communication softwares

    Directory of Open Access Journals (Sweden)

    Estivalet, Gustavo L.

    2014-11-01

    Full Text Available From the increasing growth of foreign language courses in distance education (EaD, information and communication technology (TIC have been playing a key role for the success of teaching and learning of speaking skills. Hence, synchronous communication softwares such as MSN, GoogleTalk, Skype, Voip, Dim-Dim, VZO Chat, Facebook, among others, have become essential tools for developing this skill in the interaction between students and teachers. Thus, this paper a makes a brief theoretical review of these softwares’ use in teaching speaking skills, b evaluates their use in the UFSC undergraduate distance course on Literature – Bachelor in English Language Teaching, and c discusses the use of synchronous communication softwares for teaching foreign languages in distance education. The adopted methodology included 1 observation on the use of these softwares during the course, 2 a questionnaire answered by the students, and 3 interviews with the teachers. It was observed that these softwares were used mostly in evaluation situations and that there is a demand from the students for broader interaction in foreign language through these tools in a didactic manner. Therefore, in order to develop speaking skills in foreign language in distance education, it is necessary an effective teaching practice through synchronous communication softwares. A partir do grande crescimento dos cursos de línguas estrangeiras (LE na educação a distância (EaD, as tecnologias de informação e comunicação (TIC passaram a desempenhar um papel fundamental nos processos de ensino e aprendizagem da oralidade em LE. Logo, os programas de comunicação síncrona, como MSN, GoogleTalk, Skype, Voip, Dim-Dim, VZO Chat, Facebook, entre outros, tornaram-se ferramentas essenciais na interação entre alunos e professores no desenvolvimento dessa habilidade. Este artigo realiza a uma breve revisão teórica da utilização desses programas no ensino da oralidade em LE, b avalia

  16. (MAA:EA) copolymer films

    Indian Academy of Sciences (India)

    2017-08-16

    Aug 16, 2017 ... behaviour. The interaction between oppositely charged poly- ... methods to improve the ionic conductivity, optical proper- ties, mechanical and ... liquid, filler and mixed salt systems [10,11]. Based on the ... multiple ways of preparing Cu2+ based polymer thin films. The Cu2+ ion ..... A broad and very strong.

  17. Optimization of single channel glazed photovoltaic thermal (PVT) array using Evolutionary Algorithm (EA) and carbon credit earned by the optimized array

    International Nuclear Information System (INIS)

    Singh, Sonveer; Agrawal, Sanjay; Gadh, Rajit

    2015-01-01

    Highlights: • Optimization of SCGPVT array using Evolutionary Algorithm. • The overall exergy gain is maximized with an Evolutionary Algorithm. • Annual Performance has been evaluated for New Delhi (India). • There are improvement in results than the model given in literature. • Carbon credit analysis has been done. - Abstract: In this paper, work is carried out in three steps. In the first step, optimization of single channel glazed photovoltaic thermal (SCGPVT) array has been done with an Evolutionary Algorithm (EA) keeping the overall exergy gain is an objective function of the SCGPVT array. For maximization of overall exergy gain, total seven design variables have been optimized such as length of the channel (L), mass flow rate of flowing fluid (m_F), velocity of flowing fluid (V_F), convective heat transfer coefficient through the tedlar (U_T), overall heat transfer coefficient between solar cell to ambient through glass cover (U_S_C_A_G), overall back loss heat transfer coefficient from flowing fluid to ambient (U_F_A) and convective heat transfer coefficient of tedlar (h_T). It has been observed that the instant overall exergy gain obtained from optimized system is 1.42 kW h, which is 87.86% more than the overall exergy gain of a un-optimized system given in literature. In the second step, overall exergy gain and overall thermal gain of SCGPVT array has been evaluated annually and there are 69.52% and 88.05% improvement in annual overall exergy gain and annual overall thermal gain respectively than the un-optimized system for the same input irradiance and ambient temperature. In the third step, carbon credit earned by the optimized SCGPVT array has also been evaluated as per norms of Kyoto Protocol Bangalore climatic conditions.

  18. Titanium dioxide nanoparticles induce human eosinophil adhesion onto endothelial EA.hy926 cells via activation of phosphoinositide 3-kinase/Akt cell signalling pathway.

    Science.gov (United States)

    Murphy-Marion, Maxime; Girard, Denis

    2018-02-01

    The use of nanoparticles (NPs) for developing new therapeutic strategies in a variety of diseases is gaining increasing attention. However, NPs could possess undesired effects, including pro-inflammatory activities. Despite the fact that several studies reported that NPs may induce or exacerbate eosinophilic inflammation in vivo in rodents, the information regarding the direct interaction between NPs and human eosinophils is lacking. In the present study, we test the possibility that NPs could alter the capacity of human eosinophils to adhere onto a cellular substratum. Using a panel of NPs, we found that several were able to increase the adhesion of human eosinophil onto endothelial EA.hy926 cells. Among them, TiO 2 NPs were the most potent and we therefore pursue this study with these NPs. TiO 2 NPs were found to increase the adhesion of eosinophils in a concentration dependent fashion. TiO 2 NPs did not alter the cell surface expression of a panel of cellular adhesion molecules, but CD29. Indeed, a weak to moderate, but significant, decrease of CD29 was observed after 30min but returned to normal levels after 90min. TiO 2 NPs were found to activate Akt, one important target of phosphoinositide 3-kinase (PI3K). However, despite the fact that cells were fully responsive to the cytokine GM-CSF activating both Akt and Erk-1/2, TiO 2 NPs did not activate Erk-1/2. Using a pharmacological approach with the PI3K/Akt inhibitor, wortmannin, the ability of TiO 2 NPs to activate Akt was drastically inhibited and, further, their capacity to increase adhesion of eosinophils was reversed. This study provides insights into the effects of NPs on the biology of human eosinophils indicating that as other agents, NPs, namely TiO 2 NPs, can induce intracellular events associated with a cellular function, adhesion. Copyright © 2017 Elsevier GmbH. All rights reserved.

  19. Políticas Públicas de Educação no Brasil: A Utilização da EaD Como Instrumento de Inclusão Social

    Directory of Open Access Journals (Sweden)

    José Matias Pereira

    2010-08-01

    Full Text Available The present article searchs to analyze - from the debate on the theory and the concept of education in the distance - the possibilities of intensive use of the EaD, in the context of the new public politics of education, as instrument of social inclusion in Brazil. It is verified, in this analysis that education in the distance, in a context where the continued learning started to be part in the life of the people, is presented as an important tool in the process of construction of public politics of education in the country. We conclude that, in the management of the public politics of education in the distance in Brazil must be advanced in the consistent construction of one arcabouço institucional and in the generation of stimulatons to the research in EaD, with sight to contribute for an increasing social inclusion in the country.

  20. Surface-Layer (S-Layer) Proteins Sap and EA1 Govern the Binding of the S-Layer-Associated Protein BslO at the Cell Septa of Bacillus anthracis

    Science.gov (United States)

    Kern, Valerie J.; Kern, Justin W.; Theriot, Julie A.; Schneewind, Olaf

    2012-01-01

    The Gram-positive pathogen Bacillus anthracis contains 24 genes whose products harbor the structurally conserved surface-layer (S-layer) homology (SLH) domain. Proteins endowed with the SLH domain associate with the secondary cell wall polysaccharide (SCWP) following secretion. Two such proteins, Sap and EA1, have the unique ability to self-assemble into a paracrystalline layer on the surface of bacilli and form S layers. Other SLH domain proteins can also be found within the S layer and have been designated Bacillus S-layer-associated protein (BSLs). While both S-layer proteins and BSLs bind the same SCWP, their deposition on the cell surface is not random. For example, BslO is targeted to septal peptidoglycan zones, where it catalyzes the separation of daughter cells. Here we show that an insertional lesion in the sap structural gene results in elongated chains of bacilli, as observed with a bslO mutant. The chain length of the sap mutant can be reduced by the addition of purified BslO in the culture medium. This complementation in trans can be explained by an increased deposition of BslO onto the surface of sap mutant bacilli that extends beyond chain septa. Using fluorescence microscopy, we observed that the Sap S layer does not overlap the EA1 S layer and slowly yields to the EA1 S layer in a growth-phase-dependent manner. Although present all over bacilli, Sap S-layer patches are not observed at septa. Thus, we propose that the dynamic Sap/EA1 S-layer coverage of the envelope restricts the deposition of BslO to the SCWP at septal rings. PMID:22609927

  1. Study of the peripheral projectile-like fragments from the reaction 129Xe on 27Al, natCu, 139La and 165Ho, at E/A = 50 MeV

    International Nuclear Information System (INIS)

    Garcia-Solis, E.J.; Russ, D.E.; Madani, H.

    1996-01-01

    There are several reaction mechanisms identified for peripheral heavy-ion collisions. For low bombarding energies (E/A ∼ 10 MeV) the predominant reaction channel is the deep-inelastic reaction mechanism. In this process, the projectile and target form a rotating binary system, interchanging nucleons and angular momentum until they separate. At higher bombarding energies (E/A ∼ 50 to 100 MeV) incomplete fusion is thought to be the prevailing reaction channel. In this type of interaction part of the projectile merges with the target during the collision. Finally, for energies greater than 100 MeV/A, the main reaction channel is characterized by the formation of a highly-excited separate fragment (fireball) produced during the overlap between the projectile and the target. The data set studied was from an experiment designed to characterize the projectile-like products of the 27 Al, nat Cu, 139 La, and 165 Ho reactions at E/A = 50 MeV, which was performed at the Michigan State University Super Cyclotron Laboratory (MSU-NSCL). The Maryland Forward Array (MFA), was used to measure projectile-like fragments in coincidence with target-like fragments and light-charge particles in the MSU 4π detector

  2. A non-linear detection of phospho-histone H2AX in EA.hy926 endothelial cells following low-dose X-irradiation is modulated by reactive oxygen species

    International Nuclear Information System (INIS)

    Large, Martin; Reichert, Sebastian; Hehlgans, Stephanie; Fournier, Claudia; Rödel, Claus; Rödel, Franz

    2014-01-01

    A discontinuous dose response relationship is a major characteristic of the anti-inflammatory effects of low-dose X-irradiation therapy. Although recent data indicate an involvement of a variety of molecular mechanisms in these characteristics, the impact of reactive oxygen species (ROS) production to give rise or contribute to these phenomena in endothelial cells (EC) remains elusive. HUVEC derived immortalized EA.hy926 cells were stimulated by tumor necrosis factor-α (TNF-α, 20 ng/ml) 4 h before irradiation with doses ranging from 0.3 to 1 Gy. To analyse DNA repair capacity, phospho-histone H2AX foci were assayed at 1 h, 4 h and 24 h after irradiation. ROS production and superoxide dismutase (SOD) activity were analysed by fluorometric 2′,7′-dichlorodihydrofluorescein-diacetate (H2DCFDA) and colorimetric assays. A functional impact of ROS on γH2AX production was analysed by treatment with the scavenger N-acetyl-L-cysteine (NAC). Irrespective of stimulation by TNF-α, EA.hy926 cells revealed a linear dose response characteristic of γH2AX foci detection at 1 h and 4 h after irradiation. By contrast, we observed a discontinuity in residual γH2AX foci detection at 24 h after irradiation with locally elevated values following a 0.5 Gy exposure that was abolished by inhibition of ROS by NAC. Moreover, SOD protein expression was significantly decreased at doses of 0.5 Gy and 0.7 Gy concomitant with a reduced SOD activity. These data implicate a non-linear regulation of ROS production and SOD activity in EA.hy926 EC following irradiation with doses < 1 Gy that may contribute to a discontinuous dose-response relationship of residual γH2AX foci detection

  3. Optimization of on-line hydrogen stable isotope ratio measurements of halogen- and sulfur-bearing organic compounds using elemental analyzer–chromium/high-temperature conversion isotope ratio mass spectrometry (EA-Cr/HTC-IRMS)

    Science.gov (United States)

    Gehre, Matthias; Renpenning, Julian; Geilmann, Heike; Qi, Haiping; Coplen, Tyler B.; Kümmel, Steffen; Ivdra, Natalija; Brand, Willi A.; Schimmelmann, Arndt

    2017-01-01

    Rationale: Accurate hydrogen isotopic analysis of halogen- and sulfur-bearing organics has not been possible with traditional high-temperature conversion (HTC) because the formation of hydrogen-bearing reaction products other than molecular hydrogen (H2) is responsible for non-quantitative H2 yields and possible hydrogen isotopic fractionation. Our previously introduced, new chromium-based EA-Cr/HTC-IRMS (Elemental Analyzer–Chromium/High-Temperature Conversion Isotope Ratio Mass Spectrometry) technique focused primarily on nitrogen-bearing compounds. Several technical and analytical issues concerning halogen- and sulfur-bearing samples, however, remained unresolved and required further refinement of the reactor systems.

  4. N/Z equilibration in damped collisions induced by E/A = 8.5 MeV /sup 58/Ni and /sup 64/Ni on /sup 238/U

    International Nuclear Information System (INIS)

    Planeta, R.; Zhou, S.H.; Kwiatkowski, K.

    1988-01-01

    Nuclide distributions have been measured for damped collision products formed in the reaction of E/A = 8.5 MeV /sup 58/Ni and /sup 64/Ni ions with /sup 238/U. The data demonstrate that in these very asymmetric systems the evolution of the nucleon-exchange process as a function of energy loss depends strongly on the N/Z value of the projectile and the corresponding gradient in the potential-energy surface. Comparison of the data with transport model calculations shows qualitative agreement with the N and Z centroids, variances, and correlation coefficients. However, absolute discrepancies exist which suggest the need for improvement in the model

  5. Comparative Study on Theoretical and Machine Learning Methods for Acquiring Compressed Liquid Densities of 1,1,1,2,3,3,3-Heptafluoropropane (R227ea via Song and Mason Equation, Support Vector Machine, and Artificial Neural Networks

    Directory of Open Access Journals (Sweden)

    Hao Li

    2016-01-01

    Full Text Available 1,1,1,2,3,3,3-Heptafluoropropane (R227ea is a good refrigerant that reduces greenhouse effects and ozone depletion. In practical applications, we usually have to know the compressed liquid densities at different temperatures and pressures. However, the measurement requires a series of complex apparatus and operations, wasting too much manpower and resources. To solve these problems, here, Song and Mason equation, support vector machine (SVM, and artificial neural networks (ANNs were used to develop theoretical and machine learning models, respectively, in order to predict the compressed liquid densities of R227ea with only the inputs of temperatures and pressures. Results show that compared with the Song and Mason equation, appropriate machine learning models trained with precise experimental samples have better predicted results, with lower root mean square errors (RMSEs (e.g., the RMSE of the SVM trained with data provided by Fedele et al. [1] is 0.11, while the RMSE of the Song and Mason equation is 196.26. Compared to advanced conventional measurements, knowledge-based machine learning models are proved to be more time-saving and user-friendly.

  6. Characterization of Erwinia amylovora strains from different host plants using repetitive-sequences PCR analysis, and restriction fragment length polymorphism and short-sequence DNA repeats of plasmid pEA29.

    Science.gov (United States)

    Barionovi, D; Giorgi, S; Stoeger, A R; Ruppitsch, W; Scortichini, M

    2006-05-01

    The three main aims of the study were the assessment of the genetic relationship between a deviating Erwinia amylovora strain isolated from Amelanchier sp. (Maloideae) grown in Canada and other strains from Maloideae and Rosoideae, the investigation of the variability of the PstI fragment of the pEA29 plasmid using restriction fragment length polymorphism (RFLP) analysis and the determination of the number of short-sequence DNA repeats (SSR) by DNA sequence analysis in representative strains. Ninety-three strains obtained from 12 plant genera and different geographical locations were examined by repetitive-sequences PCR using Enterobacterial Repetitive Intergenic Consensus, BOX and Repetitive Extragenic Palindromic primer sets. Upon the unweighted pair group method with arithmetic mean analysis, a deviating strain from Amelanchier sp. was analysed using amplified ribosomal DNA restriction analysis (ARDRA) analysis and the sequencing of the 16S rDNA gene. This strain showed 99% similarity to other E. amylovora strains in the 16S gene and the same banding pattern with ARDRA. The RFLP analysis of pEA29 plasmid using MspI and Sau3A restriction enzymes showed a higher variability than that previously observed and no clear-cut grouping of the strains was possible. The number of SSR units reiterated two to 12 times. The strains obtained from pear orchards showing for the first time symptoms of fire blight had a low number of SSR units. The strains from Maloideae exhibit a wider genetic variability than previously thought. The RFLP analysis of a fragment of the pEA29 plasmid would not seem a reliable method for typing E. amylovora strains. A low number of SSR units was observed with first epidemics of fire blight. The current detection techniques are mainly based on the genetic similarities observed within the strains from the cultivated tree-fruit crops. For a more reliable detection of the fire blight pathogen also in wild and ornamentals Rosaceous plants the genetic

  7. Metodologia de ensino via educação a distância (EaD) integradora e colaborativa para o ensino superior, baseada na percepção dos alunos (MAPICes)

    OpenAIRE

    Vitorino, Elizete Vieira

    2004-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. O ensino superior é o instrumento principal de transmissão da experiência cultural e científica acumulada pela humanidade. São as universidades que reúnem um conjunto de funções tradicionais associadas ao progresso e a transmissão do saber: pesquisa e inovação, ensino e formação, educação a distância (EaD). Justifica-se, então, que se desenvolvam trabalhos vol...

  8. DEMOCRACY AND DEVELOPMENT IN WEsT AFRicA: How ...

    African Journals Online (AJOL)

    that can be pursued to help meet the challenges of constructing democratic development at the ... Soviet Union and, more recently, by a number of South ... America. Gerray, Thacker and Affaro. (2006) in a new study have argued that from a ... during the cold war, western governments ... attention because of their strategic.

  9. oordrag van eiendomsreg in die vulgêre reg in die wes-romeinse ryk

    African Journals Online (AJOL)

    Mnr F Schutte

    klassieke. Romeinse reg (250vC-27vC), klassieke Romeins reg (27vC-250nC), na-klassieke Romeinse reg. (250nC-1100nC). Sien verder ook Van Zyl Romeinse Privaatreg. 3 Die vulgêre reg het die klassieke reg in die tydperk tussen 350 en ...

  10. PSU/WES interlaboratory comparative methodology study of an experimental cementitious repository seal material

    International Nuclear Information System (INIS)

    Roy, D.M.; Grutzeck, M.W.; Mather, K.

    1980-09-01

    A study is underway in two separate laboratories to investigate possible use of portland cement grout as repository sealing material for underground isolation of nuclear waste. The labs involved are the Materials Research Laboratory of the Pennsylvania State University (PSU) and the Structures Laboratory (SL) of the US Army Engineer Waterways Experiment Station. The same cementitious (grout) mixture was prepared in each laboratory in September 1980, and tests were started. Testing included characterization of cement and fly ash by chemical, physical, and petrographic procedures. Tests of hardened specimens included restrained expansion, compressive strength, modulus of elasticity, density, permeability, x-ray diffraction, and scanning electron microscopy. Each laboratory made many of the same tests and some that were not directly comparable. This document (Report 1) contains largely 3- and 7-day results and none beyond 28-day ages

  11. Design of the WES Centrifuge (Phase 3A and 3B)

    Science.gov (United States)

    1993-03-31

    the facility; heme ANS&A’a role was to encourage users from different laboratories by discussing the opportunities that presented themselves on the...the ability to interpret users’ needs and for conceptual model defintion , den aquisition and mastrking. Possible arrangements whereby RP could spend...equipment was discussed. CRREL involvement would be needed in the defintion of initial experiments and in the devdlopme of a programme for the commismoning

  12. Verhoudingsbemarking by reisagentskappe in die Wes-Kaap Provinsie / Mornay Roberts-Lombard

    OpenAIRE

    Roberts-Lombard, Mornay

    2006-01-01

    Relationship marketing has received much attention and widespread publicity over the past ten years and has moved to the forefront of research and practice. It provides companies with a management tool to establish economically profitable relationships, networks and interactions with different, but equally important stakeholder markets. The marketing concept as reflected in the four P's of the marketing mix was prominent in marketing practice and thinking until the mid-1980s, w...

  13. EDUCAÇÃO AMBIENTAL NA AMAZÔNIA: as contribuições da EA na Reserva Extrativista Marinha de São João da Ponta – PA

    Directory of Open Access Journals (Sweden)

    Indiara da Silva Oliveira

    2016-03-01

       EDUCACIÓN AMBIENTAL EN EL AMAZONAS: Las contribuciones de la EA en la Reserva Extractiva Marina de São João da Ponta – PA  RESUMEN Environmental educación es una práctica pedagógica dirigida a todos los segmentos de la sociedad y sus acciones se debe practicar con el objetivo de resolver o minimizar los problemas ambientales existentes en el nivel y / o global local. En este sentido, debido a la necesidad de la conservación de los recursos naturales y la solución o minimización de los problemas ambientales de manera que: depredadora pesca del cangrejo, la deforestación y la sedimentación en los bordes de los pantanos y arroyos, la desaparición de especies de flora y fauna y la presencia de vertederos, la Reserva Extractiva Marina de São João da Ponta - PA, las actividades de EA se llevaron a cabo a partir de la extensión universitaria, el Grupo de Estudio de Paisaje y Medio Ambiente Planificación (GEPPAM de la Facultad de Geografía y Cartografía (FGC, la Universidad Federal de Pará (UFPA. Y le tocó a este trabajo científico llamado Educación Ambiental en la Amazonía: el caso de Reserva Extractiva Marina de São João da Ponta - PA analizar estas actividades en ese RESEX, basado en los principios y objetivos de la educación ambiental, según lo definido por la Ley 9.795 / 99, el establecimiento de la Política Nacional de Educación Ambiental, así como la contribución de estas prácticas educativas para la Gestión Ambiental de la reserva en cuestión. Para el presente estudio se había utilizado la literatura y documentos, entrevistas con agentes ambientales voluntarias y el trabajo de laboratorio para la fabricación de tablas y gráficos. Sus resultados fueron prometedores, aunque todavía queda mucho por hacer para resolverlos problemas sociales y ambientales encontradas en la Reserva Extractiva Marina de São João da Ponta - PA. Palabras clave: Medio Ambiente; Gestión; Unidad de Conservación.

  14. Uma breve revisão histórica do papel das videoaulas na EaD no Brasil DOI:10.5007/1984-8420.2010v11n2p53

    Directory of Open Access Journals (Sweden)

    Aline Cassol Daga

    2010-05-01

    Full Text Available Este artigo tem como objetivo refletir sobre o papel que tem ocupado a produção e veiculação de videoaulas dentro do panorama da Educação a Distância no Brasil, principalmente no contexto de programas nacionais destinados à educação de jovens e adultos, tanto no que concerne à formação discente, quanto no que concerne à formação continuada de professores em atuação nas redes públicas de ensino. Para tanto, o artigo se divide em dois capítulos: no primeiro capítulo revisitamos a trajetória do programa Telecurso em suas três versões – Telecurso 2º grau e Telecurso 1º Grau, Telecurso 2000, Novo Telecurso; no segundo capítulo discutimos os programas de EaD vinculados à formação do professor em serviço.

  15. Calyx trademark EA implementation at AECB

    International Nuclear Information System (INIS)

    1997-01-01

    This report describes a project to examine the applicability of a knowledge-based decision support software for environmental assessment (Calyx) to assist the Atomic Energy Control Board in environmental screenings, assessment, management, and database searches. The report begins with background on the Calyx software and then reviews activities with regard to modification of the Calyx knowledge base for application to the nuclear sector. This is followed by lists of standard activities handled by the software and activities specific to the Board; the hierarchy of environmental components developed for the Board; details of impact rules that describe the conditions under which environmental impacts will occur (the bulk of the report); information on mitigation and monitoring rules and on instance data; and considerations for future work on implementing Calyx at the Board. Appendices include an introduction to expert systems and an overview of the Calyx knowledge base structure

  16. Kaks raamatut eesti kirikuloost / Ea Jansen

    Index Scriptorium Estoniae

    Jansen, Ea, 1921-2005

    2004-01-01

    Rets. rmt.: Riho Saard. Eesti rahvusest luterliku pastorkonna väljakujunemine ja vaba rahvakiriku projekti loomine, 1870-1917 ; Mikko Ketola. The nationality question in the Estonian Evangelical Lutheran Church, 1918-1939. Riho Saardi raamat käsitleb "uue eestlase" võitlust oma kiriku eest.

  17. NOAA Weather Radio - EAS Event Codes

    Science.gov (United States)

    Non-Zero All Hazards Logo Emergency Alert Description Event Codes Fact Sheet FAQ Organization Search Coding Using SAME SAME Non-Zero Codes DOCUMENTS NWR Poster NWR Brochure NWR Brochure Printing Notes

  18. H.Ea.R.T. 2013 Conference

    CERN Document Server

    Tampone, Gennaro; Zinno, Raffaele; Historical Earthquake-Resistant Timber Frames in the Mediterranean Area

    2015-01-01

    This book presents a selection of the best papers from the HEaRT 2013 conference, held in Cosenza, Italy, which provided a valuable forum for engineers and architects, researchers, and educators to exchange views and findings concerning the technological history, construction features, and seismic behavior of historical timber-framed walls in the Mediterranean countries. The topics covered are wide ranging and include historical aspects and examples of the use of timber-framed construction systems in response to earthquakes, such as the gaiola system in Portugal and the Bourbon system in southern Italy; interpretation of the response of timber-framed walls to seismic actions based on calculations and experimental tests; assessment of the effectiveness of repair and strengthening techniques, e.g., using aramid fiber wires or sheets; and modelling analyses. In addition, on the basis of case studies, a methodology is presented that is applicable to diagnosis, strengthening, and improvement of seismic performance...

  19. Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells.

    Science.gov (United States)

    Lin, Hung-Chih; Su, Shih-Li; Lin, Wan-Chun; Lin, Ai-Hsuan; Yang, Ya-Chen; Lii, Chong-Kuei; Chen, Haw-Wen

    2018-03-01

    Andrographolide is a potent anti-inflammatory agent found in Andrographis paniculata. Endothelin 1 (ET-1) is an endothelium-derived vasoconstrictor with pro-inflammatory properties secreted in response to hypoxia. Mitogen-activated protein kinase phosphatase 5 (MKP-5) is a dual-specificity phosphatase that dephosphorylates threonine and tyrosine residues of MAPKs. We showed previously that hypoxia-induced HIF-1α expression and ET-1 secretion are dependent on p38 MAPK in EA.hy926 cells. Here, we investigate what role MKP-5 plays in andrographolide's inhibition of hypoxia-induced expression of HIF-1α and ET-1. Hypoxic conditions were created using the hypoxia-mimetic agent CoCl 2 . Andrographolide enhanced HO-1 and MKP-5 expression and cellular cGMP content in addition to inhibiting hypoxia-induced ROS generation. Concomitantly, the HO-1 byproduct CO and the cGMP analogue 8-bromoguanosine 3',5'-cyclic monophosphate (8-Br-cGMP) increased MKP-5 expression, and pretreatment with CO and 8-Br-cGMP inhibited hypoxia-induced HIF-1α and ET-1 expression. Transfection of HO-1 siRNA or pretreatment with the HO-1 inhibitor ZnPP-9 or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, a specific inhibitor of soluble guanylate cyclase, reduced andrographolide-induced MKP-5 expression. Moreover, silencing MKP-5 or treatment with the phosphatase inhibitor vanadate abrogated andrographolide's suppressing hypoxia-induced p38 MAPK activation and HIF-1α expression. The inhibition of hypoxia-induced HIF-1α and ET-1 expression by andrographolide is likely associated with HO-1/CO/cGMP/MKP-5 pathways, which is involved in inhibiting hypoxia-induced p38 MAPK activation. © 2017 Wiley Periodicals, Inc.

  20. Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Hebron C. Chang

    2016-01-01

    Full Text Available Hericium erinaceus (HE is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926 cells upon tumor necrosis factor-α- (TNF-α- stimulation (10 ng/mL. The underlying molecular mechanisms behind the pharmacological efficacies were elucidated. We found that noncytotoxic concentrations of HE (50–200 μg/mL significantly inhibited TNF-α-induced migration/invasion and capillary-like tube formation of endothelial cells. HE treatment suppressed TNF-α-induced activity and/or overexpression of matrix metalloproteinase-9 (MMP-9 and intercellular adhesion molecule-1 (ICAM-1. Furthermore, HE downregulated TNF-α-induced nuclear translocation and transcriptional activation of nuclear factor-κB (NF-κB followed by suppression of I-κB (inhibitor-κB degradation. Data from fluorescence microscopy illustrated that increased intracellular ROS production upon TNF-α-stimulation was remarkably inhibited by HE pretreatment in a dose-dependent manner. Notably, HE triggered antioxidant gene expressions of heme oxygenase-1 (HO-1, γ-glutamylcysteine synthetase (γ-GCLC, and glutathione levels, which may contribute to inhibition of ROS. Increased antioxidant status was associated with upregulated nuclear translocation and transcriptional activation of NF-E2 related factor-2 (Nrf2 in HE treated cells. Our findings conclude that antiangiogenic and anti-inflammatory activities of H. erinaceus may contribute to its anticancer property through modulation of MMP-9/NF-κB and Nrf2-antioxidant signaling pathways.

  1. Hericium erinaceus Inhibits TNF-α-Induced Angiogenesis and ROS Generation through Suppression of MMP-9/NF-κB Signaling and Activation of Nrf2-Mediated Antioxidant Genes in Human EA.hy926 Endothelial Cells.

    Science.gov (United States)

    Chang, Hebron C; Yang, Hsin-Ling; Pan, Jih-Hao; Korivi, Mallikarjuna; Pan, Jian-You; Hsieh, Meng-Chang; Chao, Pei-Min; Huang, Pei-Jane; Tsai, Ching-Tsan; Hseu, You-Cheng

    2016-01-01

    Hericium erinaceus (HE) is an edible mushroom that has been shown to exhibit anticancer and anti-inflammatory activities. We investigated the antiangiogenic and antioxidant potentials of ethanol extracts of HE in human endothelial (EA.hy926) cells upon tumor necrosis factor-α- (TNF-α-) stimulation (10 ng/mL). The underlying molecular mechanisms behind the pharmacological efficacies were elucidated. We found that noncytotoxic concentrations of HE (50-200 μg/mL) significantly inhibited TNF-α-induced migration/invasion and capillary-like tube formation of endothelial cells. HE treatment suppressed TNF-α-induced activity and/or overexpression of matrix metalloproteinase-9 (MMP-9) and intercellular adhesion molecule-1 (ICAM-1). Furthermore, HE downregulated TNF-α-induced nuclear translocation and transcriptional activation of nuclear factor-κB (NF-κB) followed by suppression of I-κB (inhibitor-κB) degradation. Data from fluorescence microscopy illustrated that increased intracellular ROS production upon TNF-α-stimulation was remarkably inhibited by HE pretreatment in a dose-dependent manner. Notably, HE triggered antioxidant gene expressions of heme oxygenase-1 (HO-1), γ-glutamylcysteine synthetase (γ-GCLC), and glutathione levels, which may contribute to inhibition of ROS. Increased antioxidant status was associated with upregulated nuclear translocation and transcriptional activation of NF-E2 related factor-2 (Nrf2) in HE treated cells. Our findings conclude that antiangiogenic and anti-inflammatory activities of H. erinaceus may contribute to its anticancer property through modulation of MMP-9/NF-κB and Nrf2-antioxidant signaling pathways.

  2. Aspectos discursivos sobre/no ensino-aprendizagem de língua inglesa e na formação de professores em um curso EaD

    Directory of Open Access Journals (Sweden)

    Cristiane Carvalho de Paula Brito

    2015-05-01

    Full Text Available Resumo Este trabalho visa apresentar resultados parciais de uma investigação sobre o ensino-aprendizagem de língua inglesa (LI e formação de professores, desenvolvida em um curso de graduação em língua e literatura inglesas, em uma universidade pública mineira. À luz dos pressupostos teórico-metodológicos da Análise do Discurso francesa em interface com os estudos em Linguística Aplicada, propomo-nos a discutir: (i o desenho do curso e materiais e seu possível impacto na formação dos licenciandos; (ii as representações por eles construídas acerca dos processos de ensino-aprendizagem de LI a distância; e (iii as práticas de aprendizagem que têm sido desenvolvidas no curso. As análises apontam que a relação dos sujeitos com a LI vai se delineando e se ressignificando ao longo do curso e que as práticas de linguagem desenvolvidas no contexto das novas tecnologias se dão em processos de descontinuidade e não de uma suposta ruptura, trazendo à tona a relação singular que os sujeitos estabelecem com a língua que aprendem-ensinam. Palavras-chave: EaD, ensino-aprendizagem de língua inglesa, discurso, formação de professores.   Discursive aspects about/in English teaching-learning and teacher education in a distance course Abstract This paper presents partial results of a research on the teaching and learning of English language (EL and teacher education, developed in an undergraduate course in English language and English language literature at a public university in the State of Minas Gerais, Brazil. In light of the theoretical and methodological assumptions of the French Discourse Analysis in its interface with studies in Applied Linguistics, we propose to discuss: (i the course design and materials and their possible impact on the development of the undergraduates; (ii the representations of the processes of teaching and learning the EL at a distance as built by them; and (iii the learning practices that have been

  3. ’n Ondersoek na die bronne van werkstevredenheid en werkstres onder middelvlakbestuurders in die Wes-Kaap

    Directory of Open Access Journals (Sweden)

    S. C. Strydom

    2002-09-01

    Full Text Available The general aim of the study is to investigate the different attitudes and perceptions of middle level managers with regard to sources of job satisfaction, sources which contribute to job dissatisfaction, and to job stress. In this regard it was decided to make use of triangulation by which qualitative and quantitative research methods are used. Thematic analysis is used on the qualitative level to identify the possible sources of job satisfaction, dissatisfaction and job stress. This method is quantitatively supported by a determination of the frequencies and percentages of subject responses by means of semi structured interviews. On the qualitative level it was found that the experience of success is rated as the most important source of job satisfaction and that interpersonal relationships are the most significant source of job dissatisfaction. Finally it seems that work expectations/ demands appear to be the major source of job stress. Opsomming Die algemene doelstelling van die studie is om ondersoek in te stel na die verskillende houdings en persepsies van middelvlak-bestuurders rakende werkstevredenheid, sowel as die bronne wat bydra tot werkstres en werksontevredenheid. In dié verband is besluit om van triangulasie gebruik te maak. Op die kwalitatiewe vlak word tematiese analise gebruik om potensiële bronne van werkstevredenheid, ontevredenheid en werkstres te identifiseer. Hierdie metode word verder kwantitatief ondersteun deur ‘n bepaling van frekwensies en persentasies van subjekte se reponse wat uit semi-gestruktureerde onderhoude verkry is. Op die kwalitatiewe vlak blyk dit dat die ervaring van sukses die grootste bron van werkstevredenheid is en dat interpersoonlike verhoudings die bron is wat die meeste bydra tot ontevredenheid. Verder blyk dit dat werksverwagtinge/-eise die grootste bron van werkstres is.

  4. PSU/WES Interlaboratory Comparative Methodology Study of an Experimental Cementitious Repository Seal Material. Report 2. Final Results.

    Science.gov (United States)

    1982-03-01

    SO3 t 1.90 2.05 1.86 Na 2OS 0.09 0.21 0.15 Na2 Ott 0.12 0.11 0.12 K 2OS 0.49 0.47 0.51 K 2Ott 0.47 0.46 0.51 TiO 2S 0.19 0.18 0.18 TiO 2tt 0.19 0.20...ths ctibatiti.basI o Ot 81 ialdepencdcni ivieasiarcinctits, is 0.004 jam tafrdClstancN from I to 5 pim and 0.CtO pmr tar distatices trunm 10 to 50 pmi

  5. Paying for Higher Education. Paper No. EA026

    Science.gov (United States)

    Wyness, Gill

    2015-01-01

    The United Kingdom (UK) has dramatically increased the supply of graduates over the last four decades. The university system has successfully produced a huge increase in mass higher education over the last 40 years to meet an increased demand for skilled workers. It is one of the UK's most successful export industries in terms of attracting…

  6. 47 CFR 11.61 - Tests of EAS procedures.

    Science.gov (United States)

    2010-10-01

    ... class D non-commercial educational FM and analog and digital LPTV stations are required to transmit only... and times on all channels. (ii) DBS providers, analog and digital class D non-commercial educational... stations must conduct these tests on all audio streams. Effective December 31, 2006, DTV stations must...

  7. 47 CFR 11.11 - The Emergency Alert System (EAS).

    Science.gov (United States)

    2010-10-01

    ... transmission of data such as interactive games. Wireless Cable Systems (BRS/EBS STATIONS) [A. Wireless cable... the entity that has acquired the right to use the channels of a wireless cable system for transmission... stations including AM, FM, and Low-power FM (LPFM) stations; digital audio broadcasting (DAB) stations...

  8. Case histories of EA documents for nuclear waste

    International Nuclear Information System (INIS)

    Vocke, R.W.

    1985-01-01

    Nuclear power programs and policies in the United States have been subject to environmental assessment under the National Environmental Policy Act (NEPA) since 1971. NEPA documentation prepared for programmatic policy decision-making within the nuclear fuel cycle and concurrent federal policy are examined as they relate to radioactive waste management in this paper. Key programmatic environmental impact statements that address radioactive waste management include: the Atomic Energy Commission document on management of commercial high-level and transuranium-contaminated radioactive waste, which focussed on development of engineered retrievable surface storage facilities (RSSF); the Nuclear Regulatory Commission (NRC) document on use of recycled plutonium in mixed oxide fuel in light water cooled reactors, which focussed on plutonium recycle and RSSF; the NRC statement on handling of spent light water power reactor fuel, which focussed on spent fuel storage; and the Department of Energy (DOE) statement on management of commercially generated radioactive wastes, which focussed on development of deep geologic repositories. DOE is currently pursuing the deep geologic repository option, with monitored retrievable storage as a secondary option

  9. An EAS event observed in the early stage of development

    Science.gov (United States)

    Barroso, S. L. C.; Beggio, P. C.; de Carvalho, A. O.; Chinellato, J. A.; Mariano, A.; de Oliveira, R.; Shibuya, E. H.; Brazil-Japan Collaboration of Chacaltaya Emulsion Chamber Experiment

    2008-01-01

    Since 1969 the experiments of Brazil-Japan Collaboration showed the occurrence of a series of events, showing a region with a high concentration of electromagnetic particles, surrounded by isolated and/or groups of showers. These events were named "halo events" or "super-families". Currently, we have more than a dozen of such events. The first of them, due to its aspect, was named "Andromeda". We present here the main characteristics of a similar halo event, named C21S087I075. It has a halo region with many high energy showers in its border. Other small energy showers spread over the central and surrounding blocks (S088, S100, S101, I074). These isolated showers, classified as of hadronic or electromagnetic origin, present a fractional energy distribution compatible with that of a Centauro candidate event (C16S087I037), reported at this symposium [S.L.C. Barroso, P.C. Beggio, J.A. Chinellato, A.O. Carvalho, A. Mariano, R. Oliveira, E.H. Shibuya, in this issue of XIV ISVHECRI]. Moreover, the lateral distribution in the halo region is similar to that observed in other 3 halo events.

  10. Thermophysical Properties and Spectral Characterization of EA 6043

    Science.gov (United States)

    2014-10-01

    Russian VX (RVX) Density Antoine equation Vapor pressure Volatility Enthalpy of vaporization Entropy of vaporization Viscosity...and volatility (mg/m3), respectively, as a function of temperature. ΔHvap = RbT 2/(c + T)2 (3) where ΔHvap = enthalpy of vaporization (kJ...for vapor pressure, volatility (or saturation concentration), and enthalpy of vaporization at selected temperatures between –20 °C and the

  11. Evaluating Educational Programs. ERIC Digest Series Number EA 54.

    Science.gov (United States)

    Beswick, Richard

    In this digest, readers are introduced to the scope of instructional program evaluation and evaluators' changing roles in school districts. A program evaluation measures outcomes based on student-attainment goals, implementation levels, and external factors such as budgetary restraints and community support. Instructional program evaluation may be…

  12. 47 CFR 101.1327 - Renewal expectancy for EA licensees.

    Science.gov (United States)

    2010-10-01

    ..., including a timetable of the construction of new facilities to meet changes in demand for services provided...) In determining whether a renewal applicant has complied with the “substantial service” requirement by the end of the ten-year initial license term, the Commission may consider factors such as: (1) Whether...

  13. The new Tunka-133 EAS Cherenkov array: Status of 2009

    International Nuclear Information System (INIS)

    Antokhonov, B.V.; Beregnev, S.F.; Budnev, N.M.; Chvalaev, O.B.; Chiavassa, A.; Gress, O.A.; Kalmykov, N.N.; Karpov, N.N.; Korosteleva, E.E.; Kozhin, V.A.; Kuzmichev, L.A.; Lubsandorzhiev, B.K.; Mirgazov, R.R.; Panasyuk, M.I.; Pankov, L.V.; Prosin, V.V.; Ptuskin, V.S.; Semeney, Yu.A.; Shaibonov, B.; Silaev, A.A.

    2011-01-01

    The deployment of the new Extensive air shower Cherenkov installation Tunka-133 with about 1 km 2 geometric acceptance area was completed in October 2009. The array will permit a detailed long-term study of the cosmic ray energy spectrum and mass composition in the energy range 10 15 -10 18 eV with a unique and more elaborate method. The array construction and data acquisition system, preliminary results and plans for future development are presented.

  14. 32 CFR 651.33 - Actions normally requiring an EA.

    Science.gov (United States)

    2010-07-01

    ...) Development and implementation of Integrated Natural Resources Management Plans (INRMPs) (land, forest, fish, and wildlife) and Integrated Cultural Resources Management Plans (ICRMPs). (i) Actions that take place...), wetlands, floodplains, coastal zones, wilderness areas, aquifers or other water supplies, prime or unique...

  15. Hoea Ea: Land Education and Food Sovereignty in Hawaii

    Science.gov (United States)

    Meyer, Manulani Aluli

    2014-01-01

    This short piece offers two literal and figurative snapshots of what land education looks like in action in Hawaii. The first snapshot depicts a contemporary example of Indigenous Hawaiian taro cultivation in the Limahuli valley on the island of Kauai. The second snapshot illustrates the food sovereignty movement in Waianae, Oahu located at the…

  16. EAS fluctuation approach to primary mass composition investigation

    International Nuclear Information System (INIS)

    Stamenov, J.N.; Janminchev, V.D.

    1985-01-01

    The analysis of muon and electron fluctuation distribution shapes by statistical method of inverse problem solution gives the possibility to obtain the relative contribution values of the five main primary nuclei groups. The method is model-independent for a big class of interaction models and can give good results for observation levels not too far from the development maximum and for the selection of showers with fixed sizes and zenith angles not bigger than 30 deg

  17. Evaluation of stratospheric age of air from CF4, C2F6, C3F8, CHF3, HFC-125, HFC-227ea and SF6; implications for the calculations of halocarbon lifetimes, fractional release factors and ozone depletion potentials

    Science.gov (United States)

    Leedham Elvidge, Emma; Bönisch, Harald; Brenninkmeijer, Carl A. M.; Engel, Andreas; Fraser, Paul J.; Gallacher, Eileen; Langenfelds, Ray; Mühle, Jens; Oram, David E.; Ray, Eric A.; Ridley, Anna R.; Röckmann, Thomas; Sturges, William T.; Weiss, Ray F.; Laube, Johannes C.

    2018-03-01

    In a changing climate, potential stratospheric circulation changes require long-term monitoring. Stratospheric trace gas measurements are often used as a proxy for stratospheric circulation changes via the mean age of air values derived from them. In this study, we investigated five potential age of air tracers - the perfluorocarbons CF4, C2F6 and C3F8 and the hydrofluorocarbons CHF3 (HFC-23) and HFC-125 - and compare them to the traditional tracer SF6 and a (relatively) shorter-lived species, HFC-227ea. A detailed uncertainty analysis was performed on mean ages derived from these new tracers to allow us to confidently compare their efficacy as age tracers to the existing tracer, SF6. Our results showed that uncertainties associated with the mean age derived from these new age tracers are similar to those derived from SF6, suggesting that these alternative compounds are suitable in this respect for use as age tracers. Independent verification of the suitability of these age tracers is provided by a comparison between samples analysed at the University of East Anglia and the Scripps Institution of Oceanography. All five tracers give younger mean ages than SF6, a discrepancy that increases with increasing mean age. Our findings qualitatively support recent work that suggests that the stratospheric lifetime of SF6 is significantly less than the previous estimate of 3200 years. The impact of these younger mean ages on three policy-relevant parameters - stratospheric lifetimes, fractional release factors (FRFs) and ozone depletion potentials - is investigated in combination with a recently improved methodology to calculate FRFs. Updates to previous estimations for these parameters are provided.

  18. 75 FR 7949 - Airworthiness Directives; Extra Flugzeugproduktions- und Vertriebs- GmbH Models EA-300/200 and EA...

    Science.gov (United States)

    2010-02-23

    ..., Aerospace Engineer, FAA, Small Airplane Directorate, 901 Locust, Room 301, Kansas City, Missouri 64106... the tail spring support structure as instructed in PART II of Extra Flugzeugproduktions- und Vertriebs... tail spring support structure terminates the repetitive inspections required in paragraph (f)(1) of...

  19. Automatic digitization. Experience of magnum 8000 in automatic digitization in EA; Digitalizacion automatica. Experiencias obtenidas durante la utilizacion del sistema magnus 8000 para la digitalizacion automatica en EA

    Energy Technology Data Exchange (ETDEWEB)

    Munoz Garcia, M.

    1995-12-31

    The paper describes the life cycle to be followed for the automatic digitization of files containing rasterised (scanned) images for their conversion into vector files (processable using CAD tools). The main characteristics of each of the five phases: capture, cleaning, conversion, revision and post-processing, that form part of the life cycle, are described. Lastly, the paper gives a comparative analysis of the results obtained using the automatic digitization process and other more conventional methods. (Author)

  20. Supplemental Environmental Assessment (EA) for the Vernal Pool Restoration Project in Wing Infrastructure Development Outlook (WINDO) Implementation Plan EA, Volume 2 Beale Air Force Base, California

    Science.gov (United States)

    2010-09-01

    jamaicensis coturniculus)  Greater sandhill crane (Grus canadensis tabida)  Bank swallow ( Riparia riparia ) The Swainson’s hawk prefers to nest in...EQD) Safety Zones . These zones are established to minimize risk and exposure to individuals from explosives and explosive storage facilities...There are numerous EQD Safety Zones on the northern and southern parts of the base. The land encompassing Beale AFB was originally part of Camp Beale

  1. 78 FR 46295 - Special Conditions: Eclipse, EA500, Certification of Autothrottle Functions Under Part 23

    Science.gov (United States)

    2013-07-31

    ... persons (standard seating five people) and may be operated as a single or two pilot aircraft (reference...-4090. SUPPLEMENTARY INFORMATION: Comments Invited We invite interested people to take part in this...

  2. Environmental Assessment (EA): Proposed Construction of a Munitions Flight Maintenance Facility, Hill Air Force Base, Utah

    Science.gov (United States)

    2008-07-01

    031 /·-c.,.. ?i Ogden C.ty Ma1 tenance Area (Redes~gnated 2001) er ~~.., Sa Laice Oty Ma1 enance Alea (RedeSIQreled 1999) Pr<MYOrem...Vegetation Hill AFB is located in a geographic region that would typically support a mountain -brush type native plant community. Dominant vegetation

  3. Portfolio optimization using fundamental indicators based on multi-objective EA

    CERN Document Server

    Silva, Antonio Daniel; Horta, Nuno

    2016-01-01

    This work presents a new approach to portfolio composition in the stock market. It incorporates a fundamental approach using financial ratios and technical indicators with a Multi-Objective Evolutionary Algorithms to choose the portfolio composition with two objectives the return and the risk. Two different chromosomes are used for representing different investment models with real constraints equivalents to the ones faced by managers of mutual funds, hedge funds, and pension funds. To validate the present solution two case studies are presented for the SP&500 for the period June 2010 until end of 2012. The simulations demonstrates that stock selection based on financial ratios is a combination that can be used to choose the best companies in operational terms, obtaining returns above the market average with low variances in their returns. In this case the optimizer found stocks with high return on investment in a conjunction with high rate of growth of the net income and a high profit margin. To obtain s...

  4. Design and fabrication of two kind of SOI-based EA-type VOAs

    Science.gov (United States)

    Yuan, Pei; Wang, Yue; Wu, Yuanda; An, Junming; Hu, Xiongwei

    2018-06-01

    SOI-based variable optical attenuators based on electro-absorption mechanism are demonstrated in this paper. Two different doping structures are adopted to realize the attenuation: a structure with a single lateral p-i-n diode and a structure with several lateral p-i-n diodes connected in series. The VOAs with lateral p-i-n diodes connected in series (series VOA) can greatly improve the device attenuation efficiency compared to VOAs with a single lateral p-i-n diode structure (single VOA), which is verified by the experimental results that the attenuation efficiency of the series VOA and the single VOA is 3.76 dB/mA and 0.189 dB/mA respectively. The corresponding power consumption at 20 dB attenuation is 202 mW (series VOA) and 424 mW (single VOA) respectively. The raise time is 34.5 ns (single VOA) and 45.5 ns (series VOA), and the fall time is 37 ns (single VOA) and 48.5 ns (series VOA).

  5. 3.1.SUIT. Draft EA procedure applicable to historical areas active conservation

    DEFF Research Database (Denmark)

    Algreen-Ussing, Gregers; Wedebrunn, Ola

    2002-01-01

    This document is a preliminary draft for an Environmental Impact Assessment procedure. Its aim is to provide draft guidelines for the assessment of likely significant effects of urban development projects on the urban environment including material assets and cultural heritage. This procedure...... is intended as a way to propose and ensure an active conservation policy for urban historical areas. It is based on state-of-the-art methods and the knowledge of the experts involved in the SUIT project. It is also based on the guidelines presenting the grid of analysis to be used by stakeholders in a joint...

  6. 47 CFR 1.1308 - Consideration of environmental assessments (EAs); findings of no significant impact.

    Science.gov (United States)

    2010-10-01

    ... COMMISSION GENERAL PRACTICE AND PROCEDURE Procedures Implementing the National Environmental Policy Act of... the Bureau or the Commission to reach a determination that the proposal will or will not have a... have jurisdiction by law or which have relevant expertise. Note: With respect to actions specified...

  7. Generalized Synthesis of EAs [E = Fe, Co, Mn, Cr] Nanostructures and Investigating Their Morphology Evolution

    Directory of Open Access Journals (Sweden)

    P. Desai

    2015-01-01

    Full Text Available This paper illustrates a novel route for the synthesis of nanostructured transition metal arsenides including those of FeAs, CoAs, MnAs, and CrAs through a generalized protocol. The key feature of the method is the use of one-step hot-injection and the clever use of a combination of precursors which are low-melting and highly reactive such as metal carbonyls and triphenylarsine in a solventless setup. This method also facilitates the formation of one-dimensional nanostructures as we move across the periodic table from CrAs to CoAs. The chemical basis of this reaction is simple redox chemistry between the transition metals, wherein the transition metal is oxidized from elemental state (E0 to E3+in lieu of reduction of As3+ to As3−. While the thermodynamic analysis reveals that all these conversions are spontaneous, it is the kinetics of the process that influences morphology of the product nanostructures, which varies from extremely small nanoparticles to nanorods. Transition metal pnictides show interesting magnetic properties and these nanostructures can serve as model systems for the exploration of their intricate magnetism as well as their applications and can also function as starting materials for the arsenide based nanosuperconductors.

  8. Is the PPP valid for the EA-11 countries? New evidence from nonlinear unit root tests

    OpenAIRE

    Kavkler, Alenka; Boršič, Darja; Bekő, Jani

    2016-01-01

    In the empirical literature there is a prevalent view that real exchange rates tend to converge towards levels predicted by the Purchasing Power Parity (PPP) only in the long-run and that short-run deviations from the PPP relationship are frequently sizable. The progressing of European monetary integration and the forming of monetary union spurred the interest of researchers to assess the relevance of the PPP theory in the case of the single European currency. Our paper t...

  9. U3O8 production cost analysis study. Sandstone deposit mine model EA-730, Volume 1

    International Nuclear Information System (INIS)

    1978-08-01

    Objective was the development and testing of a model for estimating the production cost of conventional uranium mining. The model used evolved from a base case underground mine of 1000 tons per day output at a nominal depth of 900 feet, and from base-case open pit mines of 2000 tons per day output at 30-, 120-, and 240-foot depths. In addition, an alternate production method employing heap leaching was partially investigated, to be merged with similar work performed by another contractor. The model was internally structured into component submodels capable of reflecting the contributory factors which aggregate into the computed production cost. A financial submodel based on last-quarter 1976 prices used conventional accounting practices to generate a cash flow and profit-and-loss record over the mine life. From this a selling price was obtained based on a desired discounted cash flow return on equity. This submodel is also capable of accepting input inflation rates so that costs in current dollars for future years can be estimated. A Monte Carlo method of the analysis of variance was applied to 50 model runs to obtain a statistical estimate for the expected variance in production cost

  10. Schools: The Evidence on Academies, Resources and Pupil Performance. Paper No. EA023

    Science.gov (United States)

    McNally, Sandra

    2015-01-01

    England's performance in international tests of student achievement continues to be disappointing. Further improvement is essential not only for students' themselves but also for economic growth. This briefing considers the impact of Academies, school spending and teacher quality. Research evidence suggests that it is right to protect school…

  11. 15. Francis E.A. Owakah Race Ideology and the Conceptualization ...

    African Journals Online (AJOL)

    Owakah

    whether or not Africans have the same rational ability as Europeans. .... reject ethno philosophy as an approach to the study of African philosophy. ..... name as a special messenger and the interpreter of god's message (Serequeberhan. 1994 ...

  12. Design and beam transport simulations of a multistage collector for the Israeli EA-FEM

    Science.gov (United States)

    Tecimer, M.; Canter, M.; Efimov, S.; Gover, A.; Sokolowski, J.

    2001-12-01

    A four stage asymmetric type depressed collector has been designed for the Israeli mm-wave FEM that is driven by a 1.4 MeV, 1.5 A electron beam. After leaving the interaction section the spent beam has an energy spread of 120 keV and 75 π mm mrad normalized beam emittance. Simulations of the beam transport system from the undulator exit through the decelerator tube into the collector have been carried out using EGUN and GPT codes. The latter has also been employed to study trajectories of the primary and scattered particles within the collector, optimizing the asymmetrical collector geometry and the electrode potentials at the presence of a deflecting magnetic field. The estimated overall system and collector efficiencies reach 50% and 70%, respectively, with a beam recovery of 99.6%. The design is aimed to attain millisecond long pulse operation and subsequently 1 kW average power. Simulation results are implemented in a mechanical design that leads to a simple, cost efficient assembly eliminating ceramic insulator rings between collector stages and the associated brazing in the manufacturing process. Instead, each copper plate is supported by insulating posts and freely displaceable within the vacuum chamber. We report on the simulation results of the beam transport and recovery systems and on the mechanical aspects of the multistage collector design.

  13. Design and beam transport simulations of a multistage collector for the Israeli EA-FEM

    Energy Technology Data Exchange (ETDEWEB)

    Tecimer, M. E-mail: tecimer@post.tau.ac.il; Canter, M.; Efimov, S.; Gover, A.; Sokolowski, J

    2001-12-21

    A four stage asymmetric type depressed collector has been designed for the Israeli mm-wave FEM that is driven by a 1.4 MeV, 1.5 A electron beam. After leaving the interaction section the spent beam has an energy spread of 120 keV and 75 {pi} mm mrad normalized beam emittance. Simulations of the beam transport system from the undulator exit through the decelerator tube into the collector have been carried out using EGUN and GPT codes. The latter has also been employed to study trajectories of the primary and scattered particles within the collector, optimizing the asymmetrical collector geometry and the electrode potentials at the presence of a deflecting magnetic field. The estimated overall system and collector efficiencies reach 50% and 70%, respectively, with a beam recovery of 99.6%. The design is aimed to attain millisecond long pulse operation and subsequently 1 kW average power. Simulation results are implemented in a mechanical design that leads to a simple, cost efficient assembly eliminating ceramic insulator rings between collector stages and the associated brazing in the manufacturing process. Instead, each copper plate is supported by insulating posts and freely displaceable within the vacuum chamber. We report on the simulation results of the beam transport and recovery systems and on the mechanical aspects of the multistage collector design.

  14. Design and beam transport simulations of a multistage collector for the Israeli EA-FEM

    International Nuclear Information System (INIS)

    Tecimer, M.; Canter, M.; Efimov, S.; Gover, A.; Sokolowski, J.

    2001-01-01

    A four stage asymmetric type depressed collector has been designed for the Israeli mm-wave FEM that is driven by a 1.4 MeV, 1.5 A electron beam. After leaving the interaction section the spent beam has an energy spread of 120 keV and 75 π mm mrad normalized beam emittance. Simulations of the beam transport system from the undulator exit through the decelerator tube into the collector have been carried out using EGUN and GPT codes. The latter has also been employed to study trajectories of the primary and scattered particles within the collector, optimizing the asymmetrical collector geometry and the electrode potentials at the presence of a deflecting magnetic field. The estimated overall system and collector efficiencies reach 50% and 70%, respectively, with a beam recovery of 99.6%. The design is aimed to attain millisecond long pulse operation and subsequently 1 kW average power. Simulation results are implemented in a mechanical design that leads to a simple, cost efficient assembly eliminating ceramic insulator rings between collector stages and the associated brazing in the manufacturing process. Instead, each copper plate is supported by insulating posts and freely displaceable within the vacuum chamber. We report on the simulation results of the beam transport and recovery systems and on the mechanical aspects of the multistage collector design

  15. Cosmic ray nuclear interactions and EAS-triggered families observed by the Chacaltaya hybrid experiment

    International Nuclear Information System (INIS)

    Aoki, H.; Honda, K.; Inoue, N.; Ishii, T.; Kawasumi, N.; Martinic, N.; Ochi, N.; Ohmori, N.; Ohsawa, A.; Tamada, M.; Ticona, R.

    2008-01-01

    Longitudinal and lateral characteristics of the families detected by emulsion chambers in the hybrid experiment with AS-array at Mt. Chacaltaya are studied in detail. Although many groups discuss about an increase of the heavy component in primary cosmic-rays beyond the knee region, it is shown that the observed characteristics of the families accompanied by large shower size, Ne>10 6 , can not be explained by an increase of heavy primaries alone. It is necessary to assume some changes of nuclear interaction in order to explain the observed characteristics of the air-showers accompanied by families

  16. 76 FR 24874 - Initiation of Scoping for an Environmental Assessment (EA)

    Science.gov (United States)

    2011-05-03

    ... Federal holidays. Fax: 202-564-0072, ATTN: CGP Scoping Comments. Comments should be received within 30... U.S. territories with the exception of the Virgin Islands, federal facilities in four states...

  17. 76 FR 80366 - Availability of an Environmental Assessment (EA) and Finding of No Significant Impact (FONSI)

    Science.gov (United States)

    2011-12-23

    ... 20004, between 9 a.m. and 5 p.m. Eastern time, Monday through Friday, except Federal holidays. Comments... U.S. territories with the exception of the Virgin Islands, federal facilities in four states...

  18. 78 FR 68835 - Initiation of Scoping for an Environmental Assessment (EA)

    Science.gov (United States)

    2013-11-15

    ..., Washington, DC 20004, between 9 a.m. and 5 p.m. Eastern time, Monday through Friday, except Federal holidays... Columbia, Puerto Rico, all U.S. territories with the exception of the Virgin Islands, federal facilities in...

  19. Environmental Assessment (EA): Proposed Aircraft Power Systems Repair Transformation Facility, Hill Air Force Base, Utah

    Science.gov (United States)

    2007-05-16

    and silicon carbide; spent elastic abrasive media; rags and wipes from the NDI process ; and unused scraps of TIG welding wire. Dust from the thermal...used, which would not be expected to produce regulated air emissions. For this process , no air quality permit updates are anticipated. • Welding ...The electron beam welding equipment would not be expected to produce regulated air emissions. The tungsten inert gas ( TIG ) welding equipment would

  20. Final Environmental Assessment (EA) for Headquarters Building Construction and Main Gate Reconfiguration White Bluff, Spokane, Washington

    Science.gov (United States)

    2012-12-01

    in 1954 and operated as Army Nike Missile Control Site until 1963. It was then converted to a USAF satellite operations center operated by USAF...Source Study: Spokane Satellite Tracking Office. Prepared for US Army Corps of Engineers by Adams and Clark, Inc ., Spokane, WA. Archaeological and

  1. A vida ea obra de Zaíra Cintra Vidal

    Directory of Open Access Journals (Sweden)

    Gertrudes Teixeira Lopes

    2001-06-01

    Full Text Available Estudo histórico social, cujo objetivo é descrever a trajetória de Zaira Cintra Vidal, sua inserção na Escola de Enfermeiras Rachel Haddock Lobo e sua participação na Associação Brasileira de Enfermagem (ABEn. O estudo fundamenta-se nos conceitos de poder simbólico, habitus e luta simbólica de Pierre Bourdieu. As fontes primárias foram documentos existentes no Centro de Documentação da EEAN/UFRJ e no Centro de Memória da FENF/UERJ. Os dados foram obtidos no período de agosto de 2000 a abril de 2001 mediante um roteiro de análise documental. Os resultados evidenciaram que Zaira Cintra Vidal, nasceu em 05 de maio de 1903, graduou-se pela Escola de Enfermeiras do Departamento Nacional de Saúde Pública, em 1926; pós-graduou-se nos EUA de 1927 a 1929, retornando em 1943. Criou a Escola de Enfermeiras Rachel Haddock Lobo, sendo a primeira diretora por nove anos e participou na diretoria da ABEn e na redação da Revista Anais de Enfermagem.

  2. Saksa ekspert soovitab EAS-i erastada / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2003-01-01

    Saksa spetsialisti hinnangul tuleks Eestis erastada Ettevõtluse Arendamise Sihtasutus, põllumajanduse registrite ja informatsiooni amet ning teised struktuurifondide rakendusüksused. Saksamaal on enamik 50 rakendusüksusest eraomandis

  3. 78 FR 70529 - Notice of Availability for the Final Environmental Assessment (EA) and Finding No Significant...

    Science.gov (United States)

    2013-11-26

    ... FONSI for transferring the land and real estate at the Cotton Quality Research Station (CQRS) in Clemson.../property rights to the University. The Quit Claim Deed will incorporate any use restrictions identified by...

  4. Plataforma Blackboard: treinamento dos professores para a eficácia na EaD

    Directory of Open Access Journals (Sweden)

    Daniel Serravalle de Sá

    2010-08-01

    Full Text Available http://dx.doi.org/10.5007/1807-9288.2010v6n1p124 O presente artigo faz considerações sobre o uso da plataforma Blackboard Academic Suite como ferramenta de ensino no âmbito do Departamento de Espanhol, Português e Estudos Latino-Americanos (SPLAS na Universidade de Manchester. O que se oferece é um depoimento da experiência do autor enquanto um professor-usuário dessa tecnologia aplicada ao ensino. Reflete-se aqui sobre as funcionalidades da plataforma e a questão do treinamento necessário para utilização plena do programa e o sucesso da experiência educativa.

  5. Vitamin E--a selective inhibitor of the NADPH oxidoreductase enzyme system in human granulocytes

    International Nuclear Information System (INIS)

    Butterick, C.J.; Baehner, R.L.; Boxer, L.A.; Jersild, R.A. Jr.

    1983-01-01

    The cellular sites of H 2 O 2 formation in phagocytizing granulocytes have been identified with cerium chloride. A precipitate was visible in phagosomes and on plasma membranes from intact normal cells in the presence of either 0.71 mM NADH or NADPH. X-ray microanalysis permitted identification of cerium deposition within the phagosomes even in the absence of reduced pyridine nucleotides. Catalase ablated the formation of the reaction product. Intact granulocytes obtained from subjects receiving 1600 units of vitamin E daily for 2 weeks exhibited reaction product in the presence of NADH but not NADPH. Intact cells from subjects treated with vitamin E demonstrated diminished numbers of phagocytic vesicles containing reaction product. During phagocytosis the granulocytes treated with vitamin E consumed oxygen but exhibited significantly reduced rates of hydrogen-peroxide-dependent glucose-1- 14 C oxidation to 14 CO 2 . Isolated phagocytic vesicles obtained from granulocytes after ingestion of opsonized lipopolysaccharide-paraffin oil droplets contained reaction product when exposed to 0.71 mM NADPH. No reaction product was evident at 0.71 mM NADH but was evident at 2.0 mM NADH. Isolated phagocytic vesicles from the granulocytes of subjects receiving vitamin E exhibited reaction product only in the presence of NADH. These observations suggest that vitamin E interferes with the electron transport chain apparently required for the oxidation of NADPH to form H 2 O 2 in the phagocytizing granulocyte

  6. Design and beam transport simulations of a multistage collector for the Israeli EA-FEM

    CERN Document Server

    Tecimer, M; Efimov, S; Gover, A; Sokolowski, J

    2001-01-01

    A four stage asymmetric type depressed collector has been designed for the Israeli mm-wave FEM that is driven by a 1.4 MeV, 1.5 A electron beam. After leaving the interaction section the spent beam has an energy spread of 120 keV and 75 pi mm mrad normalized beam emittance. Simulations of the beam transport system from the undulator exit through the decelerator tube into the collector have been carried out using EGUN and GPT codes. The latter has also been employed to study trajectories of the primary and scattered particles within the collector, optimizing the asymmetrical collector geometry and the electrode potentials at the presence of a deflecting magnetic field. The estimated overall system and collector efficiencies reach 50% and 70%, respectively, with a beam recovery of 99.6%. The design is aimed to attain millisecond long pulse operation and subsequently 1 kW average power. Simulation results are implemented in a mechanical design that leads to a simple, cost efficient assembly eliminating ceramic i...

  7. Psub(T) analysis of multicored EAS observed by the 54m2 spark chamber

    International Nuclear Information System (INIS)

    Yamamoto, Y.; Nakatsuka, T.; Kawamoto, M.

    1982-01-01

    Rate of subcores whose axes traversed iron beams was examined by the precise measurement of air shower's arrival direction and subcore's location. As a result, it is estimated that 72,5% of subcores we picked up are from atmospheric origin and 27.5% are from iron beam origin. Psub(T) spectrum of atmospheric origin subcores made from 63 subcores (36.6%) not traversing iron beams is a little (factor = 0.7) lower than that of all subcores but alike in the slope. The cross section of large-Psub(T)-jet generating such subcores is still very large and comparable to the estimation by Cline applying QCD to large-Psub(T)-jet

  8. Environmental Assessment (EA) for the Comprehensive Range Plan (CRP), Melrose Air Force Range (AFR), New Mexico

    Science.gov (United States)

    2011-07-01

    intensity, frequency, and duration. Sound is created by acoustic energy, which produces minute pressure waves that travel through a medium (like air...concave plains associated with playa lake basins. Slope ranges from zero to 1 percent. Olton Loams – Consist of very deep, well-drained, moderately slow...gently sloping plains and upper side slopes of playas and draws. Slopes range from zero to 5 percent. 3.5.2.2 Water Resources Surface Water – The most

  9. Environmental Assessment (EA) for Replacement of the Wastewater Lift Station (Building 510)

    Science.gov (United States)

    2013-04-13

    ensure that wastewater from FEW continues to be safely and efficiently moved to the City of Cheyenne sanitary sewer system. The lift station is...from four to six inches. The subsoil is primarily alluvial clay that extends from a depth of approximately 6 to 36 inches. 8.4. Air Quality. Under...Disposal 8.6.1. Sanitary Sewer System A National Pollutant Discharge Elimination System (NPDES) permit issued by the WYDEQ is in place to allow discharge

  10. Final Environmental Assessment (EA) for Replacement of the Wastewater Lift Station (Building 510)

    Science.gov (United States)

    2013-03-01

    ensure that wastewater from FEW continues to be safely and efficiently moved to the City of Cheyenne sanitary sewer system. The lift station is...from four to six inches. The subsoil is primarily alluvial clay that extends from a depth of approximately 6 to 36 inches. 8.4. Air Quality. Under...Disposal 8.6.1. Sanitary Sewer System A National Pollutant Discharge Elimination System (NPDES) permit issued by the WYDEQ is in place to allow discharge

  11. Final Environmental Assessment (EA) for the Revitalization of Military Family Housing Keesler AFB, MS

    Science.gov (United States)

    2006-03-01

    12,000 square feet each). An Olympic-size swimming pool (approximately 71 feet by 164 feet). Twelve covered bus stops. A skateboard park...11,644 Covered Bus Stop 100 12 1,200 Skateboard Park 10,890 1 10,890 Storage Unit 100 534 53,400 Total N/A N/A 125,134 Location to be determined...Olympic-size Swimming Pool 1 1 Covered Bus Stop 5 4 3 12 Skateboard Park 1 1 Storage Unit 0 294 160 80 534 2.6 ALTERNATIVE 1 (IMMEDIATE

  12. Environmental Assessment (EA): Proposed Missile Storage Improvements, Utah Test and Training Range

    Science.gov (United States)

    2013-06-11

    801) 451 -7872 Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std. Z39.18 Hill Air Force Base, Utah Final Environmental Assessment...motors were monitored to determine their functional capability when stored in prescribed temperatures varying between -65 degrees Fahrenheit to 200...degrees Fahrenheit . One of these structures (Building 30260) was used for cryogenic or deep-freeze testing. They were hardened structures meant to

  13. Controlling microwave signals by means of slow and fast light effects in SOA-EA structures

    DEFF Research Database (Denmark)

    Sales, Salvador; Öhman, Filip; Capmany, José

    2007-01-01

    We present a novel scheme for the control of microwave signals in the optical domain. We propose the use of alternating amplifying and absorbing sections to implement phase control by using fast and slow light effects in semiconductors. The potential benefits from the proposed semiconductor optic...

  14. Emergency Communications: The Emergency Alert System (EAS) and All-Hazard Warnings

    National Research Council Canada - National Science Library

    Moore, Linda K; Reese, Shawn

    2005-01-01

    ... tested. Much has been accomplished in recent years but the current hodgepodge of warning and alert systems is inadequate for fully alerting the public about terrorist attacks or natural disasters...

  15. Heavy ion elastic and quasi-elastic scattering above E/A = 30 MeV

    International Nuclear Information System (INIS)

    Barrette, J.

    1986-05-01

    At high energy, heavy-ion elastic scattering probes the ion-ion potential in a large domain much inside the strong absorption radius. This results in a more precise determination of the real part of the nuclear potential and a consistent picture of its evolution with energy begins to emerge. It is relatively similar to that observed in light ion scattering. Even if the inelastic angular distributions seem to contain less refractive or interior contribution, coupled channel effects from these states are still important at least up to 20 MeV/n. Heavy-ion induced transfer reactions to discrete states have small cross sections but present a very strong selectivity for states with the highest available spin and could thus provide new and interesting spectroscopic information

  16. Steep and Adjustable Transfer Functions of Monolithic SOA-EA 2R-Regenerators

    DEFF Research Database (Denmark)

    Öhman, Filip; Kjær, Rasmus; Christiansen, Lotte Jin

    2006-01-01

    of a semiconductor waveguide with alternating amplifier and absorber sections using quantum-well active material. The steep nonlinearity of the transfer function is achieved by concatenating several sections. We identify the saturation properties of the absorbing media, as dictated by the band-filling and field......Measurements and numerical modeling of a reamplification and reshaping (2R) regenerator demonstrate a steep power transfer function with adjustable threshold. The threshold can be adjusted more than 6 dB by simple control of the reverse bias voltage of the absorber section. The device consists...... screening, as important for the observed transfer functions. The relation of the saturation powers of the gain and absorption sectionsis important for design optimization....

  17. Geologic and Climatic Puzzleofihe Proterozoic S nowball.··.Ea·rt·h

    Indian Academy of Sciences (India)

    excess CO2 from the atmosphere, initiating global cooling and eventually plunging the ... glacial ice cover melted the ice by greenhouse warming bringing ... Such deposits or 'tills' consist offine clay, silt or sand embedded with striated. ... Dropstones are large boulders transported by glaciers, which get dropped over tine ...

  18. 36 CFR 1010.7 - Actions that do not require an EA or EIS.

    Science.gov (United States)

    2010-07-01

    ... regulations pertaining to visitor activities; (32) Routine maintenance, property management, and resource..., fees, bonds and royalties; (5) Management, formulation, allocation, transfer and reprogramming of the... and private entities, visitors, individuals, or the general public; (9) Legislative proposals of an...

  19. belangstel. AD Pont. S. van der Linde ea, Roeping en Belofte. Ons ...

    African Journals Online (AJOL)

    Test

    Hoogs interessant is die opmerking oor die bybedoelings wat dikwels met die sending saamgegaan het sodat die sending soms tot 'n vervlakte en gesekulariseerde filantropiese besigheid ge vord het. Hoe verwoestend dit werk, het ons hier in Suid-Afrika al meer as een maal ten duurste moes ondervind. Dit doen goed om.

  20. TRE TRYCARE e.a.: De glarie van de scheep- vaari:. Nautische ...

    African Journals Online (AJOL)

    en publikasies, vir die eerste maal op 'n we- tenskaplik verantwoorde wyse gebruik ge- maak word van 'n grotendeels nog onontgon- ne goudmyn van argivalia waaroor ons eie argiefbewaarplekke beskik. Hierdie goudmyn bestaan hoofsaaklik uit boustowwe wat hul ontstaan te danke het aan die verrigtings van.

  1. [Map of Alzheimer's disease and other dementias in Spain. MapEA Project].

    Science.gov (United States)

    Martínez-Lage, Pablo; Martín-Carrasco, Manuel; Arrieta, Enrique; Rodrigo, Jesús; Formiga, Francesc

    In the current context of increased life expectancy and progressive aging of the population a very significant increase in the number of people with cognitive impairment and dementia is expected. Consequently, Spain will face an enormous social and health problem in the next decades. The Mapa de la enfermedad de Alzheimer y otras demencias en España project aims to analyse plans, prevention and early diagnosis activities, process of care and resources available across the 17 Spanish regions for the management of cognitive impairment and dementia in order to identify improvement areas, as well as to provide a list of recommendations. The working group consisted of an Advisory Committee of 5 national experts and a Committee of Experts from each region made up of professionals in the field of Neurology, Geriatrics, Psychiatry, and Primary Care, as well as representatives of Family Associations of People with Alzheimer's and other dementias. The Expert Committee of each region held meetings in which the current situation of care was reviewed. Plans available in Spain for dementia management are mostly obsolete or have not been implemented. Prevention and early detection activities are generally not carried out. There is great variability of care process that patients must follow for the diagnosis, treatment, and follow-up of the disease, and not all diagnostic test are available in different regions. In general, resources are considered scarce and unknown. The Mapa de la enfermedad de Alzheimer y otras demencias en España study has been able to detect the main points that require changing n the management, organisation, and coordination of resources, such as information and training of the personnel involved. Furthermore, the study has revealed that, in Spain, the necessary conditions are in place in Spain, such as the availability and capacity of professionals involved, as well as there being the potential diagnostic and health care resources to address this room for improvement through the approval and development of a National Alzheimer's Plan, supported by a deep and truthful political commitment, which will be the ideal framework for the development of these possibilities. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  2. 76 FR 78628 - Copper Valley Electric Association, Inc.; Notice of Application and Applicant-Prepared EA...

    Science.gov (United States)

    2011-12-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13124-003] Copper Valley... Application: Major License. b. Project No.: P-13124-003. c. Date filed: August 30, 2011. d. Applicant: Copper.... 791 (a)-825(r). h. Applicant Contact: Robert A. Wilkinson, CEO, Copper Valley Electric Association...

  3. 78 FR 65607 - Availability of the Final Environmental Assessment (EA) and Finding of No Significant Impact...

    Science.gov (United States)

    2013-11-01

    ... increase food and fiber productivity by developing new technology for safe and efficient agricultural... involvement process for Section 106 of the National Historic Preservation Act (16 U.S.C. 470(f) as provided...

  4. Environmental Assessment (EA): Proposed Emergency Power Unit Overhaul Complex at Little Mountain Test Annex, Utah

    Science.gov (United States)

    2014-03-14

    association with World War II. However, it has been previously mitigated through a memorandum of agreement between the USAF and the Utah SHPO, signed in...goldfinch Carduelis tristis T U * House sparrow Passer domesticus R C *‡ Mountain bluebird Sialia currucoides S U * Northern flicker Colaptes...been mitigated . This information is provided to assist with Section 106 responsibilities as per §36CFR800. If you have questions, please contact me at

  5. Single-Lap-Joint Screening of Hysol EA 9309NA Epoxy Adhesive

    Science.gov (United States)

    2017-05-01

    Acknowledgments This research was supported in part by the US Army Education Outreach Programs (Science and Engineering Apprentice Program and College...useful for estimating downstream logistical phase- out risk based on current and pending environmental regulations . Second-tier testing consists of...was used to ensure that the breaking load of single-lap-joint samples fell between 15% and 85% of the cell’s full-scale capacity. A crosshead speed

  6. Searching for gluon number fluctuations effects in eA collisions

    Energy Technology Data Exchange (ETDEWEB)

    Kugeratski, M. S. [Universidade Federal de Santa Catarina, Campus Joinville, Rua Presidente Prudente de Moraes, 406, CEP 89218-000, Joinville, SC (Brazil); Gonçalves, V. P.; Santana Amaral, J. T. de [Instituto de Física e Matemática, Universidade Federal de Pelotas, Caixa Postal 354, CEP 96010-900, Pelotas, RS (Brazil)

    2014-11-11

    We propose to investigate the gluon number fluctuations effects in deep inelastic electron-ion scattering at high energies. We estimate the nuclear structure function F{sub 2}{sup A}(x,Q{sup 2}), as well the longitudinal and charm contributions, using a generalization for nuclear targets of the Golec-Biernat-Wusthoff (GBW) model which describes the electron proton HERA data. Here we consider that the nucleus at high energies acts as an amplifier of the physics of high parton densities. For a first investigation we study the scattering with Ca and Pb nuclei. Our preliminary results predict that the effects of gluon number fluctuations are small in the region of the future electron ion collider.

  7. 76 FR 71619 - Availability of the Final Environmental Assessment (EA) and Finding of No Significant Impact...

    Science.gov (United States)

    2011-11-18

    ... the National Environmental Policy Act (NEPA) of 1969, 42 United States Code Sec. 4321-4347 (as amended... during regular business hours at the following location: McGinley Memorial Library, 317 Main Street... environmental policies and objectives as set forth in Section 101 of NEPA and other applicable environmental...

  8. Collective flow in Ne + Pb collisions at E/A = 400 and 800 MeV

    International Nuclear Information System (INIS)

    Gosset, J.; Babinet, R.; De Marco, N.

    1987-06-01

    Triple differential cross sections in momentum p, polar angle θ, and azimuthal angle φ with respect to the reaction plane, have been measured at the Saturne synchrotron in Saclay for collisions between neon and lead nuclei

  9. TENDÊNCIAS alimentar ea obesidade JUVENTUDE NO PAQUISTÃO

    Directory of Open Access Journals (Sweden)

    Anjum Hashmi

    2013-06-01

    Full Text Available Contexto: A epidemia de obesidade decolou por volta de 1980 e em quase todos os países tem vindo a aumentar inexoravelmente desde então. Só em 1997 foi que aceitam que este era um problema de saúde pública. Também está se tornando um importante problema de saúde pública entre as crianças do Paquistão devido a mudanças no estilo de vida e outros fatores. O aumento da prevalência da obesidade na infância e seus riscos à saúde concomitante justificam os esforços para a prevenção generalizada. Embora tanto a dieta e atividade física têm sido enfatizadas como as intervenções apropriadas, existem dados limitados sobre as tendências em alimentos e nutrientes consumidos nos jovens paquistaneses, devido à falta de dados consistentes recolhidos a nível nacional, o estudo enfoca o papel da dieta na prevenção da obesidade . Objetivos: Analisar os vários tipos de tendências alimentares em jovens levando a obesidade em jovens de escolas urbanas de alta do Paquistão. Métodos: Um estudo transversal foi conduzido entre 01 de janeiro de 2008 a 30 de Junho de 2009, em Hyderabad. Um total de 504 homens e mulheres estudantes de seis a dez grade foram selecionados por amostragem aleatória simples. Eles foram entrevistados por coletores de dados treinados através de questionário dieta. As medidas antropométricas foram realizadas com instrumentos calibrados com a idade eo sexo do IMC específicos pontos de corte de acordo com a OMS, referência de crescimento. Resultados: A prevalência de sobrepeso (percentil> 85 e obesidade (percentil> 95 foi de 23% e 15% entre os meninos, respectivamente, enquanto que nas meninas a prevalência de sobrepeso e obesidade foi de 16% e 8% respectivamente. A cintura com as taxas de quadril (RCQ é outra medida de obesidade central, juntamente com o IMC. Uma percentagem significativa de meninas (86% e meninos (85% tiveram RCQ anormal. Cerca de 83% das crianças não trouxe qualquer almoço / lanche na escola. Mais da metade (56% comeu alguma refeição em um restaurante fast food. Por último cerca de 31% das escolas promovida empresas de fast food para abrir suas bancas nas instalações da escola. A análise multivariada mostrou as variáveis de freqüência alimentar especificamente, laticínios (P = 0,21, amido (P = 0,846, hortaliças (P = 0,095. Finalmente, aqueles que comiam mais frutas do que 4 vezes por semana tinham 55% (OR 0,45 menor probabilidade de serem obesos do que aqueles que comiam menos do que 4 vezes por semana (P = 0,02 Conclusão: Os determinantes da obesidade estão dentro das rápidas mudanças nas tendências de alimentos e padrões de vida que teve um impacto claro e significativo sobre a prevalência de obesidade em jovens de Pakistan.Successful intervenções de prevenção da obesidade dos jovens incluem a família e programas baseados na escola, educação em saúde sobre a nutrição, a campanha de mídia, atividade física e aconselhamento.

  10. PCR nuclear composition at 1-20 PeV according to lateral distributions of all EAS and EAS accompanied high-energy-gamma rays and hadrons in EC at Tien-Shan level

    International Nuclear Information System (INIS)

    Nesterova, N.M.; Pavlyuchenko, V.P.; Chubenko, A.P.; Shaulov, S.B.

    2003-01-01

    The Tien-Shan array Adron data are presented on electron-photon component lateral distributions (age parameter S) of extensive air showers of cosmic rays. The data are given as a dependence on the electron size N e for all showers and for showers accompanied by high-energy gamma rays and hadrons in X-ray films. N e characterizes the energy of primary-cosmic-ray nuclei E 0 . Later events are generated by primary photons chiefly. That allows judging on the proton role with E 0 change. S distributions point to the considerable part of light nuclei, protons mainly, at the region above knee of the spectrum at N e > 10 6 up to N e = 5 x 10 6 (E 0 ∼ 10 PeV) at least [ru

  11. Environmental Assessment with Finding of No Significant Impact (EA/FONSI) for New Mobile Aircraft Fire Trainer

    Science.gov (United States)

    2010-04-23

    communities. The major compositional trend of the vegetation over time is toward an increased density of conifers , especially in the Montane zone...important plant or animal species; interfered substantially with wildlife movement or reproductive behavior; resulted in a substantial infusion of...with wildlife movement or reproductive behavior. The MAFT site is adjacent to know PMJM habitat. Potential impacts to vegetation would not be

  12. The decay of hot nuclei formed in La-induced reactions at E/A=45 MeV

    International Nuclear Information System (INIS)

    Libby, B.

    1993-01-01

    The decay of hot nuclei formed in the reactions 139 La + 27 Al, 51 V, nat Cu, and 139 La were studied by the coincident detection of up to four complex fragments (Z > 3) emitted in these reactions. Fragments were characterized as to their atomic number, energy and in- and out-of-plane angles. The probability of the decay by an event of a given complex fragment multiplicity as a function of excitation energy per nucleon of the source is nearly independent of the system studied. Additionally, there is no large increase in the proportion of multiple fragment events as the excitation energy of the source increases past 5 MeV/nucleon. This is at odds with many prompt multifragmentation models of nuclear decay. The reactions 139 La + 27 Al, 51 V, nat Cu were also studied by combining a dynamical model calculation that simulates the early stages of nuclear reactions with a statistical model calculation for the latter stages of the reactions. For the reaction 139 La + 27 Al, these calculations reproduced many of the experimental features, but other features were not reproduced. For the reaction 139 La + 51 V, the calculation failed to reproduce somewhat more of the experimental features. The calculation failed to reproduce any of the experimental features of the reaction 139 La + nat Cu, with the exception of the source velocity distributions

  13. Epstein-Barr virus early antigen diffuse (EBV-EA/D)-directed immunoglobulin A antibodies in systemic lupus erythematosus patients

    DEFF Research Database (Denmark)

    Draborg, A H; Jørgensen, J M; Müller, H

    2012-01-01

    We sought to determine whether the serological response towards lytic cycle antigens of Epstein-Barr virus (EBV) is altered in systemic lupus erythematosus (SLE) patients.......We sought to determine whether the serological response towards lytic cycle antigens of Epstein-Barr virus (EBV) is altered in systemic lupus erythematosus (SLE) patients....

  14. Structure Identification Using High Resolution Mass Spectrometry Data and the EPA’s CompTox Chemistry Dashboard (EAS)

    Science.gov (United States)

    The iCSS CompTox Dashboard is a publicly accessible dashboard provided by the National Center for Computation Toxicology at the US-EPA. It serves a number of purposes, including providing a chemistry database underpinning many of our public-facing projects (e.g. ToxCast and ExpoC...

  15. Environmental Chemistry Compound Identification Using High Resolution Mass Spectrometry Data Integrated to the EPA Chemistry Dashboard (EAS)

    Science.gov (United States)

    There is a growing need for rapid chemical screening and prioritization to inform regulatory decision-making on thousands of chemicals in the environment. We have previously used high-resolution mass spectrometry to examine household vacuum dust samples using liquid chromatograph...

  16. 78 FR 70356 - Compliance With Order EA-13-109, Order Modifying Licenses With Regard to Reliable Hardened...

    Science.gov (United States)

    2013-11-25

    ... Licenses With Regard to Reliable Hardened Containment Vents Capable of Operation Under Severe Accident... Regard to Reliable Hardened Containment Vents Capable of Operation under Severe Accident Conditions... capable of a operation under severe accident conditions. This ISG also endorses, with clarifications, the...

  17. 78 FR 57418 - Compliance With Order EA-13-109, Order Modifying Licenses With Regard to Reliable Hardened...

    Science.gov (United States)

    2013-09-18

    ... Licenses With Regard to Reliable Hardened Containment Vents Capable of Operation Under Severe Accident... Capable of Operation under Severe Accident Conditions.'' (ADAMS Accession No. ML13247A417) This draft JLD... Containment Vents Capable of Operation under Severe Accident Conditions'' (ADAMS Accession No. ML13130A067...

  18. Simulation of final states in ep and eA collisions at the LHeC using DPMJET-III

    CERN Document Server

    Armesto, N

    2010-01-01

    $e$p and $e$Pb collisions at the LHeC are simulated using DPMJET-III. Four events classes: inclusive, inelastic non-diffractive, single diffractive on the photon side and coherently diffractive, are generated. Particle and energy pseudorapidity distributions, and distributions on forward neutron multiplicity and rapidity gap existence, are shown.

  19. Possible measurements of gamma ray astronomy through the detection of EAS particles in Chacaltaya (5220 m a. s. 1. )

    Energy Technology Data Exchange (ETDEWEB)

    Morello, C; Navarra, G; Martinic, N; Miranda, P; Turtelli, Junior, A

    1986-01-01

    Since the beginning of August '82 an array for measurements of cosmic ray variations is operating at the Chacaltaya Laboratory (Bolivia, 5220 m a.s.1.). The possibility of using the same detector for measurements of high energy gamma-ray astronomy from the Galactic Center and the sources PSR 0833-45 and Centaurus A is discussed. In one year of continuous operation a flux: S(E/sub 0/>2.5 x 10/sup 4/ GeV) = 10/sup -11/ Ph/cm/sup 2/ sec can be detected from a point source within a confidence level of 3 s.d.

  20. 75 FR 2107 - Notice of Availability of the Draft Environmental Assessment (Draft EA) for the Urban Stream...

    Science.gov (United States)

    2010-01-14

    ... proposed project. The construction of the Urban Stream Research Center is one component ecological... localized construction-related impacts to air quality and increases in noise from the use of construction...

  1. Two-proton interferometry at backward angles in 16O + 197Au at E/A = 94 MeV

    International Nuclear Information System (INIS)

    Lautridou, P.; Quebert, J.; Peghaire, A.; Saint-Laurent, F.

    1988-01-01

    Backward angle measurements of the p-p correlation function at small relative momenta exhibit a damping of final state interactions. This new shape is analysed in the framework of Fermi-Dirac statistical effects for which a characteristic lifetime of the order of 10 -21 s is deduced

  2. INFLUENCE OF SOLUBLE PLACENTAL TISSUE-DERIVED MOLECULES UPON EXPRESSION OF ADHESION MOLECULES BY EA.HY926 ENDOTHELIAL CELLS

    Directory of Open Access Journals (Sweden)

    O. I. Stepanova

    2011-01-01

    Full Text Available Abstract.  Leukocyte  recruitment  to  placental  tissue  is  an  important  factor  of  its  development.  In  this respect, adhesion molecules at the endothelial cell surface represent a key determining factor of leukocyte adhesion and their trans-endothelial migration. The goal of investigation was to evaluate changed expression of adhesion molecules on the endothelial cells induced by supernates of placental tissue cultures. Placental tissue supernatants produced by the first- and third-trimester placental tissue from normal pregnancy, as well as from women with gestosis, induced higher expression of CD31, CD9, CD62E, CD62P, CD34, CD54, CD51/61, CD49d  and  integrin  β7  expression  by  endothelial  cells,  as  compared  with  their  baseline  levels.  However, the  supernates  from  pre-eclamptic  placental  tissue (3rd  trimester  caused  an  increased  CD9  expression by  endothelial  cells,  as  compared  with  effects  of placental  supernates  from  eclampsia-free  cases.  Our data  contribute  to  understanding  a  possible  role  of endothelial cell adhesion molecules in recruitment of leukocytes to placental tissue and possible participation of adhesion molecules in pathogenesis of pre-eclampsia. The work was supported by a grant from Russian Ministry of Education and Science ГК №02.740.11.0711 and Presidential grant № НШ-3594.2010.7 and МД-150.2011.7. (Med. Immunol., 2011, vol. 13, N 6, pp 589-596

  3. East African highland bananas (Musa spp. AAA-EA) 'worry' more about potassium deficiency than drought stress

    NARCIS (Netherlands)

    Taulya, G.

    2013-01-01

    Drought stress, potassium (K) and nitrogen (N) deficiencies are major constraints to rain-fed East African highland banana (EAHB) production in Uganda. It was hypothesised that the reduction in fresh bunch mass and increase in dry matter (DM) allocation to corms with drought stress, K and N

  4. 76 FR 54525 - Notice of Availability of a Final Environmental Assessment (Final EA) and a Finding of No...

    Science.gov (United States)

    2011-09-01

    ... administrative space requirements and will be able to accommodate state-of-the-art equipment upgrades. The... fencing; replacement of the 8 element V-Ring antenna on the Runway 32R instrument landing system with a 14... the environmental analysis. Issued in Des Plaines, Illinois, on August 22, 2011. Virginia Marcks...

  5. 75 FR 9015 - Notice of Availability of a Final Environmental Assessment (Final EA) and a Finding of No...

    Science.gov (United States)

    2010-02-26

    ... construction and operation of a new ATCT at TVC. The replacement ATCT will be a Low Activity Level facility... operational characteristics. The existing antenna and shelter will be removed once the new equipment is... been used as guidance in the preparation of the environmental analysis. Issued in Des Plaines, Illinois...

  6. Final Environmental Assessment (EA), Long-Term Integrated Management of Mission-Generated Solid Waste, Edwards Air Force Base, California

    Science.gov (United States)

    2016-11-28

    surrounding communities within the Antelope Valley. Major industries in the area include agriculture, mining, and tourism , in addition to aerospace...festivals, sports , and other leisure pursuits, plus the attractions of the nearby Los Angeles metropolitan area make Edwards AFB a great jumping-off

  7. QMD simulation of multifragment production in heavy ion collisions at E/A=600 MeV

    International Nuclear Information System (INIS)

    Begemann-Blaich, M.; Mueller, W.F.J.; Aichelin, J.; Hubele, J.; Imme, G.; Leray, S.; Lindenstruth, V.; Liu, Z.; Lynen, U.; Meijer, R.J.; Milkau, U.; Moroni, A.; Ogilvie, C.A.; Pochodzalla, J.; Raciti, G.; Schuettauf, A.; Stuttge, L.; Tucholski, A.

    1993-04-01

    With the ALADIN forward spectrometer the fragmentation of gold nuclei at 600 MeV per nucleon after interaction with carbon, aluminum, copper and lead targets has been investigated. The results are compared to quantum-molecular-dynamics calculations using soft and hard equations of state as well as soft equation of state with momentum dependent forces. Whereas the QMD has been successfully applied to heavy ion collisions at lower energies, it is not possible to reproduce the fragment distributions and the light particle multiplicities observed in this experiment at relativistic energies. To study the reasons for the discrepancy between the experimental data and the simulations, we investigated the time evolution of the nuclear system after a collision and the disintegration pattern of excited nuclei in the QMD approach. (orig.). 9 figs

  8. Possible measurements of gamma ray astronomy through the detection of EAS particles in Chacaltaya (5220 m a.s.1.)

    International Nuclear Information System (INIS)

    Morello, C.; Navarra, G.; Martinic, N.; Miranda, P.; Turtelli Junior, A.

    1986-01-01

    Since the beginning of August'82 an array for measurements of cosmic ray variations is operating at the Chacaltaya Laboratory (Bolivia, 5220 m a.s.1.). The possibility of using the same detector for measurements of high energy Gamma-Ray Astronomy from the Galactic Center and the sources PSR 0833-45 and Centaurus A is discussed. In one year of continuous operation a flux: S(E 0 >2.5x10 4 GeV) = 10 -11 Ph/cm 2 sec can be detected from a point source within a confidence level of 3 s.d. (Author) [pt

  9. 77 FR 67862 - Notice of Availability of the Final Environmental Assessment (EA) and Finding of No Significant...

    Science.gov (United States)

    2012-11-14

    ... City Hall, Engineering Department, 123 S. Lincoln St., Aberdeen, SD 57401. Alexander Mitchell Library.... Peck, Acting Manager, Manager, Bismarck Airport District Office FAA, Great Lakes Region. [FR Doc. 2012...

  10. Study of the multi-fragment production in asymmetric heavy ion reactions at E/A = 600 MeV

    International Nuclear Information System (INIS)

    Hubele, J.C.

    1992-03-01

    In this thesis the fragmentation of Au projectiles in collisions with light target nuclei ( 12 C, 27 Al, 64 Cu) is studied at a projectile energy of 600 MeV per nucleon. For the description of an event three observables are used: the multiplicity M lp of the light particles, the largest observed charge Z max of the projectile fragments, as well as a newly introduced obsevable Z bound , which is defined as the sum of all charge contained in complex projectile fragments (Z ≥ 2). By means of this observable different exit channels can be identified: the formation of a heavy residual nucleus by evaporation of light particles, the binary fission, the decay into IMF's (3 ≤ Z ≤ 30) and the complete decay into light particles. At the applied incident energy in the case of Au+Cu reactions each of these decay channels can be realized. The observables Z bound and M lpp are proved as suited quantities for the reconstruction of the impact parameter. Furthermore independently on the target a universal relation between Z bound and the multiplicity distribution of medium-heavy fragments is found. By simple model assumptions it is made plausible that Z bound is correlated both with the size of the projectile residue and in the mean with its excitation energy. For the characterization of the decay into IMF's the multiplicity M imf of these fragments is applied. For all three targets with increasing centrality first an increasing of the mean fragment multiplicities to maximal values of 3-4 is observed. In the case of the Cu target and suggestively also at the Al target in the most central collisions again a decreasing of the multiplicity is found. The universal Z bound behaviour is a hint to a - at least partial - equilibration of the primary projectile residue before the decay. (HSI) [de

  11. Hydrogen isotope determination by TC/EA technique in application to volcanic glass as a window into secondary hydration

    Science.gov (United States)

    Martin, Erwan; Bindeman, Ilya; Balan, Etienne; Palandri, Jim; Seligman, Angela; Villemant, Benoit

    2017-12-01

    The use of volcanic glass as recorder of paleoenvironmental conditions has existed for 30 years. In this paper we investigate the methodological aspects of the determination of water content, isotopic composition, and water speciation in volcanic glass using the High Temperature Conversion/Elemental Analyzer (TCEA) mass spectrometer system on milligram quantities of glass concentrates. It is shown here that the precision and the reproducibility of this method is comparable to off-line conventional methods that require 100 times greater amount of material (δD ± 3‰; [H2O]tot ± 10relative% if 1 wt%) but is quicker and permits easy replication. This method extracts 100% of the water as verified by FTIR measurements. Finally, this study confirms the interest of DRIFT spectroscopy in the NIR range for the study of porous samples such as volcanic pumices and tephra, to determine the water speciation (H2O/OH). It may complement conventional FTIR transmission measurements in the MIR or NIR range that usually require homogeneous transparent sections or high degree of sample dilution in a non-absorbing matrix. Using these methods, we attempt to discriminate residual magmatic from secondary meteoric water in volcanic glass. Using mafic to differentiated samples from different geological settings and different climatic conditions, we show that the H-isotope composition and water content of volcanic glass alone are not always sufficient to provide clear distinction between magmatic and meteoric origin. However if the magma is known to have a δD between - 90‰ and - 40‰ (- 60‰ for MORB mantle source), it is quite easy to resolve the δD evolution during magmatic degassing from post-depositional rehydration by meteoric water with δD - 20‰. Water speciation measurements may provide additional information. In most cases, isotopic and total water measurements should be complemented by characterization of water speciation. During magmatic degassing (from 6 wt% to 0.1 wt% water) the H2O/OH is expected to decrease from 2 to close to 0. However, our dataset suggests that during secondary glass hydration (from 0.1 wt% to 6 wt% water) the H2O/OH ratio decreases from 5 to 2, which is the complete opposite. Overall our results support the use of H-isotopes of volcanic glass to discuss the composition of meteoric waters and paleo-climate within a specific region. To this purpose, the volcanic glass has to be almost fully rehydrated in order to fingerprint the isotopic composition of the ambient environmental water. As rehydration is exponentially faster with increasing temperature, efficient rehydration taking months to years, may occur in a cooling volcanic deposits that are meters-thick and thus can remain at a few hundred °C for a years to hundreds of years after the eruption. Such deposits could then provide a snap-shot view of climatic conditions at the time of the studied eruption.

  12. Preliminary study to characterize plastic polymers using elemental analyser/isotope ratio mass spectrometry (EA/IRMS).

    Science.gov (United States)

    Berto, Daniela; Rampazzo, Federico; Gion, Claudia; Noventa, Seta; Ronchi, Francesca; Traldi, Umberto; Giorgi, Giordano; Cicero, Anna Maria; Giovanardi, Otello

    2017-06-01

    Plastic waste is a growing global environmental problem, particularly in the marine ecosystems, in consideration of its persistence. The monitoring of the plastic waste has become a global issue, as reported by several surveillance guidelines proposed by Regional Sea Conventions (OSPAR, UNEP) and appointed by the EU Marine Strategy Framework Directive. Policy responses to plastic waste vary at many levels, ranging from beach clean-up to bans on the commercialization of plastic bags and to Regional Plans for waste management and recycling. Moreover, in recent years, the production of plant-derived biodegradable plastic polymers has assumed increasing importance. This study reports the first preliminary characterization of carbon stable isotopes (δ 13 C) of different plastic polymers (petroleum- and plant-derived) in order to increase the dataset of isotopic values as a tool for further investigation in different fields of polymers research as well as in the marine environment surveillance. The δ 13 C values determined in different packaging for food uses reflect the plant origin of "BIO" materials, whereas the recycled plastic materials displayed a δ 13 C signatures between plant- and petroleum-derived polymers source. In a preliminary estimation, the different colours of plastic did not affect the variability of δ 13 C values, whereas the abiotic and biotic degradation processes that occurred in the plastic materials collected on beaches and in seawater, showed less negative δ 13 C values. A preliminary experimental field test confirmed these results. The advantages offered by isotope ratio mass spectrometry with respect to other analytical methods used to characterize the composition of plastic polymers are: high sensitivity, small amount of material required, rapidity of analysis, low cost and no limitation in black/dark samples compared with spectroscopic analysis. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. 78 FR 65606 - Availability of the Final Environmental Assessment (EA) and a Finding of No Significant Impact...

    Science.gov (United States)

    2013-11-01

    ...) has made a FONSI for transferring the land and real estate at the JPC-NRCC in Watkinsville, Georgia... rights to the Board of Regents of the University System of Georgia. The Quit Claim Deed will incorporate...

  14. Inteligencia colectiva en los juegos sociales en Facebook Zynga versus EA Playfish: empresas, usuarios, contenidos e interacciones /

    OpenAIRE

    Díaz Álvarez, Lluïsa

    2015-01-01

    El fenómeno de los juegos sociales en Facebook ha resultado un paradigma de cambio dentro de la industria del videojuego. En este proceso vemos involucrados diversos factores como las empresas, los contenidos, los usuarios y las interacciones producidas entre ellos. Estos elementos están íntimamente relacionados y no podemos entender el proceso sin tener en cuenta las interrelaciones establecidas en el entorno digital. Esta tesis trata precisamente sobre esto: cómo interactúan estos factores ...

  15. Projectile and target fragmentation at intermediate energies (20 MeV <= E/A <= 100 MeV)

    International Nuclear Information System (INIS)

    Dayras, R.A.

    1985-04-01

    In order to follow the evolution of the reaction mechanisms in the transition region of the intermediate energy range, detailed studies of projectile-like fragments from a 44 MeV/u 40 Ar projectile bombarding 27 Al and sup(NAT)T: targets have been made. Experimental results are given. Discussion of the data is presented: transfer reactions, isotopic distributions, the fragmentation model, and abrasion model are used in the discussion

  16. The Effectiveness of Biofertilizer on Plant Growth Soyb Ea N “Edam Am E” (Glycin Max)

    OpenAIRE

    Sudiarti, Diah

    2017-01-01

    This study aimed at determining the effectiveness of biofertilizer with different concentrations on plant growth of soybean “edamame” (glycin max). Biofertilizer in this study consists of microbial consortia (lactobacillus, pseudomonas, bacillus, saccharomyces, rhizobium, azotobacter, azospirillum, and cellulomonas). The treatment consists of 3 biofertilizer concentrations (25%, 50%, dan 75%), as well as the negative control and positive control (100% chemical fertilizer equivalent 5g/plant)....

  17. Elastic scattering of 16O+16O at energies E/A between 5 and 8 MeV

    International Nuclear Information System (INIS)

    Nicoli, M. P.; Haas, F.; Freeman, R. M.; Aissaoui, N.; Beck, C.; Elanique, A.; Nouicer, R.; Morsad, A.; Szilner, S.; Basrak, Z.

    1999-01-01

    The elastic scattering of 16 O+ 16 O has been measured at nine energies between E lab =75 and 124 MeV. The data cover up to 100 degree sign in the c.m. and can be described in terms of phenomenological and folding model potentials which reproduce the main features observed. In agreement with studies at higher energies in this and similar systems, refractive effects are present in the angular distributions at all energies. In particular, the passage of Airy minima through 90 degree sign at E c.m. =40, 47.5, and 62 MeV explains the deep minima observed in the excitation function. The real part of the optical potential is found to vary very little with energy over the studied interval, but the imaginary part shows a rapid change in its shape at incident energy about 90 MeV. Nonetheless, the energy dependence of the volume integral of the real and imaginary parts is in agreement with dispersion relation predictions. (c) 1999 The American Physical Society

  18. 77 FR 58112 - Notice of Intent To Prepare an Environmental Assessment (EA) for the Proposed Conveyance of Land...

    Science.gov (United States)

    2012-09-19

    ... transition away from an economy focused largely on DOE and Hanford activities to one based on private sector... community in the transition away from an economy focused largely on DOE and Hanford-related funding...; ecological resources; cultural and historic resources; geology and soils; water resources; climate and air...

  19. Mitigating risks associated with Lockout/Tagout (LOTO) of hazardous energy in Nigeria : a tracker approach / E.A. Aghenta.

    OpenAIRE

    Aghenta, Emmanuel Aigbokhaibho

    2012-01-01

    The main objective of the study was to determine the risk(s) associated with lockout/tagout of hazardous energy and propose a new LOTO procedure which tracks the implementation of LOTO to mitigate against identified risks as a basis for promotion of safety. The study focuses on electrical personnel working in PHCN. Only electrical accident risks are examined, not other types of risk e.g. mechanical, chemical, and nuclear. To gather material for this study, a questionnaire was distributed ...

  20. Search for characteristics of preequilibrium protons emitted in Ar + Ag collisions at E/A = 27 MeV

    International Nuclear Information System (INIS)

    Jouan, D.; Rivet, M.F.; Borderie, B.; Gauvin, H.; Cabot, C.; Fuchs, H.; Gardes, D.; Jacquet, D.; Monnet, F.; Montoya, M.

    1987-12-01

    Protons emitted in coincidence with heavy residues have been measured, for the reaction 27 MeV per nucleon 40 Ar + nat Ag. From the proton velocity spectra, an anisotropic component was extracted, which shows a broad angular distribution, and a mean velocity larger than the beam velocity. Multiplicities for this component are low, about 0.8, independent of the violence of the collision. For central collisions, selected via the higher heavy residue velocities, the velocity characteristics of the anisotropic component, seen in this case as a pure preequilibrium component, were compared to semi-classical calculations (Landau-Vlasov)

  1. Evolution of the reaction 40Ar + Ag from E/A = 7 to 34 MeV

    International Nuclear Information System (INIS)

    Alexander, J.M.

    1991-01-01

    The 4π charged-particle multidetector AMPHORA has been used to study the reaction 40 Ar + nat Ag from 270 - 1,356 MeV. Charged-particle multiplicity distributions show a low-multiplicity group associated with peripheral collisions and a high multiplicity group associated with central collisions. Average multiplicities for central collisions increase with increasing projectile energy, indicating ever-increasing collision violence. Angular distributions of emitted protons are essentially isotorpic for θ ≥ 80 degree in a reference frame characterized by the empirical systematics of linear momentum transfer (i.e. ∼ 100% to ∼ 70% from 7-34 MeV/nucleon). Spectra of these protons at side angles are evaporation-like in shape and indicate relative effective temperatures of 3, 6, 8, and 12 MeV for beam energies of 7, 17, 27 and 34 MeV respectively. Azimuthal angular correlations between various pairs are consistent with spin-driven emission from emitter sources of reasonable spin values. In short, these results support a classical picture of extensively thermalized emitter nuclei even for initial excitation energies of ∼ 5 MeV per system nucleon and spins of ≥ 100ℎ

  2. Nucleon exchange properties of the E/A=8.5 MeV 74Ge+165Ho reaction

    International Nuclear Information System (INIS)

    Planeta, R.; Kwiatkowski, K.; Zhou, S.H.; Viola, V.E.; Breuer, H.; McMahan, M.A.; Kehoe, W.; Mignerey, A.C.

    1990-01-01

    Mass and charge distributions have been measured for damped projectile-like fragments in the reaction 74 Ge+ 165 Ho at 8.5 MeV per nucleon bombarding energy. Coincidences were measured between Z- and A-identified projectile-like fragments and angle-correlated heavy reaction partners in order to derive the primary mass distribution for projectile-like fragments. Centroids and variances of the primary and post-evaporative Z, N, and A distributions are presented. The evolution of the primary N and Z distributions as a function of energy loss is found to deviate from predictions of the nucleon exchange transport model

  3. 78 FR 78943 - Notice of Availability (NOA) of an Environmental Assessment (EA) for the Temporary Storage of...

    Science.gov (United States)

    2013-12-27

    ... Defense Supply Center Richmond, Virginia AGENCY: Defense Logistics Agency, DoD. ACTION: Notice of... at Defense Supply Center Richmond, Virginia. SUMMARY: The Defense Logistics Agency (DLA) announces... Engelberger at (703) 767-0705 during normal business hours Monday through Friday, from 8:00 a.m. to 4:30 p.m...

  4. Spatiotemporal characteristics of heat waves over China in regional climate simulations within the CORDEX-EA project

    Science.gov (United States)

    Wang, Pinya; Tang, Jianping; Sun, Xuguang; Liu, Jianyong; Juan, Fang

    2018-03-01

    Using the Weather Research and Forecasting (WRF) model, this paper analyzes the spatiotemporal features of heat waves in 20-year regional climate simulations over East Asia, and investigates the capability of WRF to reproduce observational heat waves in China. Within the framework of the Coordinated Regional Climate Downscaling Experiment (CORDEX), the WRF model is driven by the ERA-Interim (ERAIN) reanalysis, and five continuous simulations are conducted from 1989 to 2008. Of these, four runs apply the interior spectral nudging (SN) technique with different wavenumbers, nudging variables and nudging coefficients. Model validations show that WRF can reasonably reproduce the spatiotemporal features of heat waves in China. Compared with the experiment without SN, the application of SN is effectie on improving the skill of the model in simulating both the spatial distributions and temporal variations of heat waves of different intensities. The WRF model shows advantages in reproducing the synoptic circulations with SN and therefore yields better representations for heat wave events. Besides, the SN method is able to preserve the variability of large-scale circulations quite well, which in turn adjusts the extreme temperature variability towards the observation. Among the four SN experiments, those with stronger nudging coefficients perform better in modulating both the spatial and temporal features of heat waves. In contrast, smaller nudging coefficients weaken the effects of SN on improving WRF's performances.

  5. 10 CFR Appendix C to Subpart D of... - Classes of Actions that Normally Require EAs But Not Necessarily EISs

    Science.gov (United States)

    2010-01-01

    ... management program C6. Implementation of Power Marketing Administration systemwide erosion control program C7... Marketing Administration system-wide vegetation management program. C6Implementation of a Power Marketing... 10 average megawatts or more over a 12 month period. This applies to power marketing operations and...

  6. 77 FR 41811 - In the Matter of Tennessee Valley Authority Watts Bar Nuclear Plant EA-12-021; Confirmatory Order...

    Science.gov (United States)

    2012-07-16

    ... ADR session mediated by a professional mediator, arranged through Cornell University's Institute on... representative) to digitally sign documents and access the E-Submittal server for any proceeding in which it is... for accessing the E-Submittal server are detailed in NRC's ``Guidance for Electronic Submission...

  7. Final Environmental Assessment (EA) Addressing the Repair of Runway 05/23 at Fairchild Air Force Base, Washington

    Science.gov (United States)

    2009-11-01

    farmland is defined as land that has the best combination of physical and chemical characteristics for producing food, feed, forage, fiber , and...flows. Layers of basalt could be as much as 500 feet thick with gravel, silt, or pyroclastic deposits interbedded. During the Pleistocene (from...unconformably atop the bedrock and is composed of weakly lithified sedimentary deposits from a Miocene-aged shallow lake. The Columbia River Basalts

  8. Differences in the Psychosocial Work Environment of Different Types of Schools.

    Science.gov (United States)

    Docker, John G.; And Others

    1989-01-01

    Discusses the use of the Work Environment Scale (WES) to measure teachers' perceptions of psychosocial dimensions of their school environment. Describes an application of WES in which work climates of different school types were compared and contrasted. (RJC)

  9. 76 FR 34914 - Energy Conservation Program for Consumer Products and Certain Commercial and Industrial Equipment...

    Science.gov (United States)

    2011-06-15

    ... CONTACT: Mr. Wes Anderson, U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy...: (202) 586-7335. E-mail: Wes.Anderson@ee.doe.gov . In the Office of General Counsel, contact Ms...

  10. 76 FR 30555 - Energy Conservation Program for Consumer Products: Test Procedures for Residential Central Air...

    Science.gov (United States)

    2011-05-26

    [email protected] . FOR FURTHER INFORMATION CONTACT: Mr. Wes Anderson, U.S. Department of Energy, Office... Avenue, SW., Washington, DC 20585-0121. Telephone: (202) 586-7335. E-mail: Wes.Anderson@ee.doe.gov . Ms...

  11. Æstet til sidste blodige krumme

    DEFF Research Database (Denmark)

    Schubart, Rikke

    2014-01-01

    Rikke Schubart interviewer instruktør Wes Anderson om hans nye film The Grand Budapest Hotel (2014)......Rikke Schubart interviewer instruktør Wes Anderson om hans nye film The Grand Budapest Hotel (2014)...

  12. Accommodating World Englishes in Developing EFL Learners' Oral Communication

    Science.gov (United States)

    Mukminatien, Nur

    2012-01-01

    This article aims to discuss issues of World Englishes (WEs) and the implications in ELT. It explores the extent to which WEs are taken into account as emerging English varieties different from inner circle varieties, how WEs should be accommodated by English teachers, and which standard to adopt to accommodate learner's linguistic needs for…

  13. Example-Based Learning: Effects of Different Types of Examples on Student Performance, Cognitive Load and Self-Efficacy in a Statistical Learning Task

    Science.gov (United States)

    Huang, Xiaoxia

    2017-01-01

    Previous research has indicated the disconnect between example-based research focusing on worked examples (WEs) and that focusing on modeling examples. The purpose of this study was to examine and compare the effect of four different types of examples from the two separate lines of research, including standard WEs, erroneous WEs, expert (masterly)…

  14. The Future of World Englishes in Language Testing

    Science.gov (United States)

    Brown, James Dean

    2014-01-01

    This article begins by defining "world Englishes" (WEs) and the related paradigm of inner-, outer-, and expanding-circle English(es). The discussion then turns to the central concerns of the WEs and language testing (LT) communities with regard to how English tests can best be constructed to include various WEs by discussing (a) what…

  15. Fluxes of 10-2000 GeV hadrons in EAS produced by 1-100 PeV PCR according to Tien Shan data

    International Nuclear Information System (INIS)

    Nesterova, N.M.; Pavlyuchenko, V.P.; Chubenko, A.P.; Shchepetov, A.L.; Mukhamedshin, R.A.

    2005-01-01

    The experimental data on the hadrons spectra with the energy of 10-2000 GeV in the extensive air showers with the electrons number N e =3 x 10 5 -10 8 at the distances of 3-60 m from the axis are obtained at the Tien-Shan mountainous facility (690 g/cm 2 ) by means of the 18NM64 neutron monitor and ionization calorimeter. The obtained results are compared with the calculations by the MS0-model. The comparison shows that the singular hadrons experimental number significantly exceeds the calculational value. This may be brought by the change in the PCR character and its interaction with the air atoms nuclei by the energies above several PeV [ru

  16. Routinely used immunoassays do not detect circulating anti-GBM antibodies against native NC1 hexamer and EA epitope of the α3 chain of type IV collagen.

    Science.gov (United States)

    Clavarino, Giovanna; Gauthier, Arnaud; Hellmark, Thomas; Carron, Pierre-Louis; Giovannini, Diane; Colliard, Sophie; Dragon-Durey, Marie-Agnès; Segelmark, Mårten; Cesbron, Jean-Yves; Dumestre-Pérard, Chantal

    2018-04-12

    Detection of circulating anti-GBM antibodies has a key role for the diagnosis of Goodpasture syndrome but immunoassays using purified or recombinant alpha3(IV)NC1 as antigen do not recognize all anti-GBM antibodies. We show that anti-GBM antibodies directed against epitopes in their native conformation or cryptic epitopes are detected by indirect immunofluorescence. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Experimental study of Au+Au collisions at E/A=150 and 400 MeV: comparison with the GQMD-matrix model

    International Nuclear Information System (INIS)

    Ramillien, V.

    1995-07-01

    We present new experimental data obtained with the FOPI detector at the SIS Heavy ions accelerator (Darmstadt, Germany), for the Au + Au heavy ion collisions at 150 and 400 A.MeV incident energy. The sideward flow, determined form the method of Danielewicz without reaction plane reconstruction, and the nuclear stopping are studied as a function of the centrality of the collisions and as a function of the fragment charge. In order to study the nuclear in-medium effects, which act on the N-N cross-sections and potential and hence on experimental observables like the nuclear matter flow and stopping, these results are compared with the predictions of two different QMD versions. The first one (GQMD) offers a fully microscopic calculation of the cross-sections and potential in the G-matrix formalism and naturally includes the in-medium effects. This version is for the first time confronted to experiment. The second one (IQMD) uses a standard Skyrme potential plus a momentum dependent term in order to mimic the in-medium effects. We find that the experimental stopping is overestimated for 30-40% in the models IQMD and GQMD. Concerning the flow, we find that the momentum dependence of the potential in GQMD is somewhat stronger as can be seen for the more peripheral events and fits better the data in this case. On the other hand, the model GQMD clearly lacks of density dependence to reproduce the more central events. (author). 52 refs., 57 figs., 11 tabs

  18. Impact parameter selected nuclear temperatures of hot nuclei from excited state populations for 40Ar+197Au reactions at E/A=25MeV

    International Nuclear Information System (INIS)

    Li Zuyu; He Zhiyong; Duan Limin; Jin Genming; Wu Heyu; Zhang Baoguo; Wen Wanxin; Qi Yujin; Luo Qingzheng; Dai Guangxi; Wang Hongwei

    1997-01-01

    Nuclear temperatures extracted from excited state populations were measured as a function of linear momentum transfer (LMT) for 40 Ar+ 197 Au reactions at 25MeV/nucleon. The emission temperatures increased slightly with increasing linear momentum transfer or decreasing impact parameter. Taking into account the corrections of detection efficiency and sequential feeding from higher-lying states, a temperature of T∼4MeV was deduced for central collisions. For peripheral collisions the extracted temperatures increased with the energy of the particles. (orig.)

  19. Study of the correlation of gamma-ray families with the EAS by the Monte-Carlo simulation and a suggested future experiment

    International Nuclear Information System (INIS)

    Kasahara, K.; Torii, S.; Yuda, T.

    1981-01-01

    To examine information which may be obtained by the simultaneous observation of gamma-ray families and accompanying air showers, a Monte-Carlo simulation is carried out under various assumptions for primary cosmic rays and nuclear interactions. It is shown that only proton primary can produce those families that have energy greater than ΣEsub(γ) approximately=100 TeV with air shower size less than 10 5 ; other heavy primaries such as alpha, carbon etc always generate larger sizes than 10 5 for families ΣEsub(γ)>=100 TeV. Therefore we will be able to select families generated by proton primaries and discuss the character of nuclear interaction at very high energies without suffering from the problem of imitations of various new characters (large Pt, large multiplicity etc) by heavy primaries. Moreover, it is shown that the chemical composition of the primaries at >=10 15 eV region is possibly studied through ΣEsub(γ)-size correlation

  20. Analysis of 13C-mixed triacylglycerol in stool by bulk (EA-IRMS) and compound specific (GC/MS) methods.

    Science.gov (United States)

    Slater, C; Ling, S C; Preston, T; Weaver, L T

    2002-06-01

    This paper was presented in poster form at the 17th International Congress of Nutrition, August 27-31, Vienna, Austria (Annals of Nutrition & Metabolism 2001; 45(Suppl.1):349). Some of the data were also presented in poster form at the British Society of Gastroenterology Meeting, March 18-21, Glasgow, UK (Gut 2001; 48(Suppl.1):A91). The 13C-mixed triacylglycerol (MTG) breath test is used to measure intraluminal fat digestion. In normal digestion, 20-40% of the ingested 13C label is recovered in breath CO2. We aimed to identify the proportions of ingested label excreted in stool, as well as breath following ingestion of 13C-MTG by children with impaired exocrine pancreatic function and healthy controls. 13C enrichment of breath samples was measured by continuous flow isotope ratio mass spectrometry (IRMS) and cumulative percent dose recovered (cPDR) in 10 h was calculated. Total 13C of a faecal fat extract from each stool was measured by elemental analyser-IRMS, and 13C enrichment and concentration of the TBDMS derivative of octanoic acid was measured by GC/MS after hydrolysis of the fat extract. Stool 5-day cPDR was calculated. Mean breath cPDR was 35%. Mean cPDR in stool by combustion-IRMS and GC/ MS, respectively, was 0.8% and 1.0%. Therefore, the remaining 64% of the 13C label must remain in the body and variability in breath cPDR is due to postabsorptive rather than predigestive factors.

  1. Selection of assessment methods for evaluating banana weevil Cosmopolites sordidus (Coleoptera: Curculionidae) damage on highland cooking banana (Musa spp., genome group AAA-EA).

    Science.gov (United States)

    Gold, C S; Ragama, P E; Coe, R; Rukazambuga, N D T M

    2005-04-01

    Cosmopolites sordidus (Germar) is an important pest on bananas and plantains. Population build-up is slow and damage becomes increasingly important in successive crop cycles (ratoons). Yield loss results from plant loss, mat disappearance and reduced bunch size. Damage assessment requires destructive sampling and is most often done on corms of recently harvested plants. A wide range of damage assessment methods exist and there are no agreed protocols. It is critical to know what types of damage best reflect C. sordidus pest status through their relationships with yield loss. Multiple damage assessment parameters (i.e. for the corm periphery, cortex and central cylinder) were employed in two yield loss trials and a cultivar-screening trial in Uganda. Damage to the central cylinder had a greater effect on plant size and yield loss than damage to the cortex or corm periphery. In some cases, a combined assessment of damage to the central cylinder and cortex showed a better relationship with yield loss than an assessment of the central cylinder alone. Correlation, logistic and linear regression analyses showed weak to modest correlations between damage to the corm periphery and damage to the central cylinder. Thus, damage to the corm periphery is not a strong predictor of the more important damage to the central cylinder. Therefore, C. sordidus damage assessment should target the central cylinder and cortex.

  2. EAS spectrum in the primary energy region above 10 to the 15th power eV by the Akeno and Yakutsk array data

    Science.gov (United States)

    Krasilnikov, D. D.; Knurenko, S. P.; Krasilnikov, A. D.; Pavlov, V. N.; Sleptsov, I. Y.; Yegorova, V. P.

    1985-01-01

    The extensive air showers spectrum on scintillation desity Rko in primary energy region E sub approx. 10 to the 15th power - 10 to the 20th power eV on the Yakutsk array data and recent results of the Akeno is given.

  3. New results from Ooty EAS array for cosmic sources at PeV energies: Cygnus X-3, Crab pulsar and Sco X-1

    International Nuclear Information System (INIS)

    Tonwar, S.C.; Gupta, S.K.; Gopalakrishnan, N.V.; Rajeev, M.R.; Srivatsan, R.; Sreekantan, B.V.

    1990-01-01

    Ooty group has reported detection of a steady signal from Cyg X-3 based on observations made during 1984-86 through detection of a directional excess. Further analysis of data has revealed a significant flux enhancement during April 1986, confirming observations reported by the CYGNUS group at Los Alamos and the Baksan group. These results show conclusively that the flux from Cyg X-3 is variable over a time scale of few weeks. We also report here the details of an unusual burst from Cyg X-3, consisting of 5 showers in 13 minutes, on June 19, 1985, which shows the variability of the flux from Cyg X-3 on a much shorter time scale of few minutes. Our analysis of showers arriving from the direction of the Crab pulsar has shown only a small time-averaged excess. But these data, when folded with the Crab pulsar period, show a very significant excess at the expected phase of the optical interpulse. This is the first detection of 33 ms pulsation in the PeV energy flux from the Crab pulsar. The exact alignment of the phase of emission over nearly 20 decades of energy, from meter wavelengths to PeV, makes the Crab pulsar a really unique source to study and understand details of mechanisms for emission and acceleration of particles in compact sources. We also present here a discussion of our observations on another X-ray binary, Sco X-1. Ooty data show a very significant excess in the number of showers from the direction of Sco X-1 during a two month period in 1986, in agreement with observations reported by the Mt. Chacaltaya group. These observations establish this X-ray binary as another important source of PeV energy radiation. (orig.)

  4. Coincidence measurements of intermediate mass fragments produced in /sup 32/S-induced reactions on Ag at E/A = 22.5 MeV

    International Nuclear Information System (INIS)

    Fields, D.J.; Lynch, W.G.; Nayak, T.K.

    1986-01-01

    Single- and two-particle inclusive cross sections for the production of light nuclei and intermediate mass fragments, 3< or =Z< or =24, were measured at angles well beyond the grazing angle for /sup 32/S-induced reactions on Ag at 720 MeV. Information about fragment multiplicities and reaction dynamics was extracted from measurements of light particles, intermediate mass fragments, and targetlike residues in coincidence with intermediate mass fragments. Incomplete linear momentum transfer and non-compound-particle emission are important features of collisions producing intermediate mass fragments. About half of the incident kinetic energy in these collisions is converted into internal excitation. The mean multiplicity of intermediate mass fragments is of the order of 1. Particle correlations are strongly enhanced in the plane which contains the intermediate mass fragment and the beam axis

  5. Ada Compiler Validation Summary Report: Certificate Number: 901112W1. 11116 Cray Research, Inc., Cray Ada Compiler, Release 2.0, Cray X-MP/EA (Host & Target)

    Science.gov (United States)

    1990-11-12

    semaphores : 0.00 44858 Waiting on shared registers : 0.00 0 Waiting on A-registers/funct.units : 19.69 5551338711 Waiting on S-registers/funct.units...dependent bodies that implement the fundamental low-level primitives on which SR-3082 2.0 Cray Research, Inc. 73 Ada Program Runtime Model Cray Ada...operations provided by the runtime library are performed synchronously , with program execution suspended until the 1/O operation is complete. The

  6. Qual o impacto do conhecimento de informática no desempenho acadêmico dos alunos de EaD?

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-01-01

    Full Text Available Com a globalização e a difusão da internet ganhou impulso extraordinário, nos últimos anos, a educação à distância (EAD, por meio de aulas transmitidas através de websites e atividadescumpridas pelos alunos em seus próprios computadores. O EAD vem facilitar o acesso ao ensino para as pessoas que trabalham ou possuem baixo poder aquisitivo, devido ao seu custo reduzido e a exibilidades de horários. Apesar de existir há mais de 150 anos no mundo, somente nas últimas décadas a educação à distância se tornou alvo de estudos e pesquisas acadêmicas, de forma sistematizada. Neste contexto, o objetivo desta pesquisa é avaliar o impacto do conhecimentoem informática no desempenho acadêmico dos alunos de EAD da Faculdade COC. Foi realizada uma pesquisa exploratória não probabilística na Faculdade Interativa COC – EAD, Pólo Lafaiete – Ribeirão Preto. Tal pesquisa consistiu em um questionário com 21 questões dicotômicas qualitativas, relativas ao grau de conhecimento e domínio das tecnologias de informação e ensino à distância, disponibilidade de acesso a estas tecnologias, além do sexo e desempenho acadêmico(média ponderada e nota no último módulo. Os dados foram tabulados, sendo consideradas duas variáveis principais: desempenho acadêmico, representado pela nota do último módulo; e conhecimento em informática, representado pela somatória das questões relativas a este assunto. Os dados foram analisados estatisticamente, sendo a correlação entre as duas variáveis consideradas analisada pelo teste de Correlação de Pearson. Foram analisadas as entrevistas de 54respondentes do curso de Administração (44,45% do sexo masculino e 55,55% sexo feminino. O coeficiente de correlação r=0,303 indica que há uma correlação significativa entre o desempenho acadêmico dos alunos (nota e seu conhecimento em informática, ou seja, quanto maior o domínio da informática melhores as notas obtidas por estes alunos no curso à distância. O ensino a distância tem como principal ferramenta a informática, de maneira que aqueles alunos com menor conhecimento em tecnologia da informação encontram uma barreira que reflete no seudesempenho acadêmico. As notas são calculadas através de: atividades eletrônicas, provas presencial e eletrônica, atividades avaliativas, de maneira que quem tem dificuldades com o computador,terá maiores dificuldades de acessar estes recursos, concluir com sucesso tais atividades, e até mesmo se apropriar do conhecimento.

  7. Qual o impacto do conhecimento de informática no desempenho acadêmico dos alunos de EaD?

    Directory of Open Access Journals (Sweden)

    Eduardo de Paula e Silva Chaves

    2013-10-01

    Full Text Available Com a globalização e a difusão da internet ganhou impulso extraordinário, nos últimos anos, a educação à distância (EAD, por meio de aulas transmitidas através de websites e atividades cumpridas pelos alunos em seus próprios computadores. O EAD vem facilitar o acesso ao ensino para as pessoas que trabalham ou possuem baixo poder aquisitivo, devido ao seu custo reduzido e a flexibilidades de horários. Apesar de existir há mais de 150 anos no mundo, somente nas últimas décadas a educação à distância se tornou alvo de estudos e pesquisas acadêmicas, de forma sistematizada. Neste contexto, o objetivo desta pesquisa é avaliar o impacto do conhecimento em informática no desempenho acadêmico dos alunos de EAD da Faculdade COC. Foi realizada uma pesquisa exploratória não probabilística na Faculdade Interativa COC – EAD, Pólo Lafaiete – Ribeirão Preto. Tal pesquisa consistiu em um questionário com 21 questões dicotômicas qualitativas, relativas ao grau de conhecimento e domínio das tecnologias de informação e ensino à distância, disponibilidade de acesso a estas tecnologias, além do sexo e desempenho acadêmico (média ponderada e nota no último módulo. Os dados foram tabulados, sendo consideradas duas variáveis principais: desempenho acadêmico, representado pela nota do último módulo; e conhecimento em informática, representado pela somatória das questões relativas a este assunto Os dados foram analisados estatisticamente, sendo a correlação entre as duas variáveis consideradas analisada pelo teste de Correlação de Pearson. Foram analisadas as entrevistas de 54 respondentes do curso de Administração (44,45% do sexo masculino e 55,55% sexo feminino. O coeficiente de correlação r=0,303 indica que há uma correlação significativa entre o desempenho acadêmico dos alunos (nota e seu conhecimento em informática, ou seja, quanto maior o domínio da informática melhores as notas obtidas por estes alunos no curso à distância. O ensino a distância tem como principal ferramenta a informática, de maneira que aqueles alunos com menor conhecimento em tecnologia da informação encontram uma barreira que reflete no seu desempenho acadêmico. As notas são calculadas através de: atividades eletrônicas, provas presencial e eletrônica, atividades avaliativas, de maneira que quem tem dificuldades com o computador, terá maiores dificuldades de acessar estes recursos, concluir com sucesso tais atividades, e até mesmo se apropriar do conhecimento.

  8. Impact parameter dependent light particle correlations for 40Ar induced reactions on 197Au at E/A = 60 MeV

    International Nuclear Information System (INIS)

    Kyanowski, A.

    1987-01-01

    With the help of a multidetector system of 96 plastic detectors, mounted in the forward hemisphere between 3 0 and 30 0 , we measured light charged particles to make an off-line event-type selection. The final aim to distinguish different impact parameter domains with the plastic wall could be achieved using the observed multiplicity as the sampling parameter. With the help of a computer simulation based on a participant-spectator model to describe the reation, the mean observed multiplicity could be established to vary smoothly with the total multiplicity, a variable which is often cited as an indicator for the violence of a reaction. Even if the simulation indicates a broad distribution of the observed multiplicity over the different impact parameters, we could separate the extreme cases of peripheral and central collisions. If the events are selected with the appropriate multiplicity gates, it turns out that peripheral collisions give rise to enhanced correlations, whereas the correlation function is strongly reduced for central collisions. Between these extreme values the correlation reduces smoothly with the impact parameter. The space-time extent of the emitting system is therefore larger for small impact parameters than in peripheral collisions. Supposing that the spatial extent is rather independent of the impact parameter (except for very peripheral collisions) we suggest that the observed variation of the correlation function could indicate a variation of the emission time for light particles rather than a spatial evolution. On the contrary the temperature, determined equally after an event-type selection with the observed multiplicity, shows no variation with the impact parameter. This could indicate that a limiting temperature is reached at a value at which the emission of particles is faster than the temporal development of the temperature. (orig./HSI)

  9. Tipología de Estrategias de Aprendizaje para la Comprensión Lectora en Inglés en la Modalidad EaD

    OpenAIRE

    Mónica Gilda González de Doña; María José Marcovecchio; Viviana Margarit; Laura Ureta

    2008-01-01

    En el presente trabajo se propone una tipología de estrategias que promuevan la comprensión de textos científicos en inglés en una modalidad a distancia. Son cada día más numerosas las propuestas pedagógicas soportadas por las nuevas tecnologías, por lo que se ha vuelto imperativo ofrecer programas y cursos no convencionales que contemplen la inclusión de la enseñanza de la lecto-comprensión en inglés. En base a nuestra experiencia en la modalidad presencial, un lector eficiente d...

  10. Inelastic 12C(12C, 12C)12C scattering via the Glauber optical potential at E/A=30 MeV and 85 MeV

    International Nuclear Information System (INIS)

    Chauvin, J.; Lebrun, D.; Durand, F.; Buenerd, M.

    1984-07-01

    It is shown that some approximations implied in the optical limit of the Glauber theory are justified for low energies heavy-ions surface collisions. The Glauber optical potential -with no free parameters- leads to reasonable predictions for both elastic and inelastic scattering in the 12 C + 12 C system

  11. Analisi dei margini di convenienza aziendali-distrettuali in alcuni modelli organizzativi di gestione degli effluenti di allevamento (EA). Un confronto tra casi di riferimento in Veneto

    OpenAIRE

    Brighenti , Alberto

    2013-01-01

    The topic of this research is the study of new models for the management of livestock effluents, in particular situations of concentration or bad organization, is able to produce negative externality for the environment, especially loss in the underground and surface water of nitrate. This problem of water pollution in one hand is a cost for the community, because the citizen wants clean water and in the other is a cost for the livestock firm, because is constricted to respect an environmenta...

  12. Tipología de Estrategias de Aprendizaje para la Comprensión Lectora en Inglés en la Modalidad EaD

    Directory of Open Access Journals (Sweden)

    Mónica Gilda González de Doña

    2008-01-01

    Full Text Available En el presente trabajo se propone una tipología de estrategias que promuevan la comprensión de textos científicos en inglés en una modalidad a distancia. Son cada día más numerosas las propuestas pedagógicas soportadas por las nuevas tecnologías, por lo que se ha vuelto imperativo ofrecer programas y cursos no convencionales que contemplen la inclusión de la enseñanza de la lecto-comprensión en inglés. En base a nuestra experiencia en la modalidad presencial, un lector eficiente debe contar con el conocimiento y manejo de las estrategias cognitivas y metacognitivas involucradas en el proceso de lectura. Asimismo, debe desarrollar estrategias de decodificación que le permitan abordar textos en el idioma inglés. Sumado a esto, en un entorno a distancia, el proceso se vuelve más complejo ya que el lector debe adquirir estrategias de manejo de las TICs. A partir de la tipología sugerida, el lector hará uso de aquellas que le sean pertinentes según la problemática cognitiva planteada y su propio estilo de aprendizaje. Nuestra propuesta surge de la necesidad de facilitarle al estudiante enfrentar el doble desafío que implica por un lado, desenvolverse en un entorno virtual y por el otro, abordar textos de su especialidad en un idioma desconocido.

  13. Exclusive measurement of the Ne = Pb → π ±, H, He at E/A = 400 and 800 MeV

    International Nuclear Information System (INIS)

    Poitou, J.; Babinet, R.; De Marco, N.

    1987-06-01

    This work is part of a systematic investigation of Ne-nucleus collisions undertaken with the 4 π detector Diogene. Only data obtained with Ne at 400 and 800 MeV/A on Pb nuclei are presented. Experimental data are also compared with the resuts of an intranuclear cascade calculation which takes, into account nuclear binding, Pauli blocking and isospin

  14. Proton-proton correlations at small relative momentum in neon-nucleus collisions at E/A=400 and 800 MeV

    International Nuclear Information System (INIS)

    Dupieux, P.; Alard, J.P.; Augerat, J.; Bastid, N.; Charmensat, P.; Fraysse, L.; Marroncle, J.; Montarou, G.; Parizet, M.J.; Qassoud, D.; Rahmani, A.; Fodor, Z.

    1988-01-01

    Proton-proton small angle correlations have been measured in neon-nucleus collisions, using the 4π detector Diogene, at 400 and 800 MeV per nucleon incident energies. Values of the size of the emitting region are obtained by comparison with the Koonin formula, taking into account the biases of the apparatus. The dependence of the density of target mass and incident energy is also analysed. (orig.)

  15. Fragment production and collective Behaviour in central 197Au + 197Au reactions at E/A = 100 MeV to 800 MeV

    International Nuclear Information System (INIS)

    Wienold, T.

    1993-07-01

    In this thesis results of the reaction Au on Au at incident energies of 100 to 800 MeV/u are preentes, which were obtained with the phase 1 of the 4π detector system at the GSI in Darmstadt. The studies are concentrated to collective behaviour and the production of medium-heavy fragments (IMF) in hot and dense nuclear matter, as it is produced in semicentral and central collisions. The data set consists of the measurement of triple respectively quadruple differential cross sections of charged fragments in a large range of the phase space over nearly one order of magnitude in the incident energy. In this thesis for the first time the existence of a central source of medium-heavy fragments in very central collisions is shown. For this new criteria for the event selection are applied, as the combination of large particle multiplicity and the absence of a directed sideward flow, or the degree of the stopping in the energy flow. The analysis of the central source yielded a large mean IMF multiplicity of 13±2 (extrapolated to 4π, 100 MeV/u incident energy). Furthermore the quantitative change of the directed sideward flow with the ''centrality'' of the collisions was evaluated. With the measurments performed here now a new data set exists, which prepares many observables for the test of the numerous theoretical transport theories

  16. Wind Energy Solutions : to bring renewable energy everywhere

    International Nuclear Information System (INIS)

    Baigent, K.

    2006-01-01

    This presentation provided details of Wind Energy Solutions (WES) Canada's current activities and research innovations. Established initially in Holland in 2004, WES Canada's corporate activities include technology development; licensing, registration and approvals; product development; manufacturing and distribution; and global service and maintenance training. WES Canada is the exclusive importer of WES turbines for Canada and the United States, and offers turnkey wind energy solutions for local dealers and installers. WES product technology aims to provide flexible logistics, as well as to facilitate local production and project development. WES turbines range from 2.5 kW to 250 KW and are available for both on-site power generation and grid-connected applications. The presentation provided specifications for the WES 5 Tulipo wind turbine, a low noise level, low vibration turbine that provides 2 independent safety systems: a failsafe brake on fast shaft of gear; and emergency yawing. A series of photographs demonstrated the installation process of the Tulipo. It was noted that many WES turbines are used in farming applications, as the turbine fits easily on 1 truck, and is easy to install with a foundation made by a local contractor using WES technical drawings engineered for local soil conditions. The turbine is also suitable for factories, harbours, schools and remote villages. It was concluded that the turbines have been specifically engineered for cold climates, as an imbalance control will prevent operation when the blades have significant ice build-up. refs., tabs., figs

  17. Experimental study of Au+Au collisions at E/A=150 and 400 MeV: comparison with the GQMD-matrix model; Etude experimentale des collisions Au+Au a E/A=150 et 400 MeV: comparaison avec le modele matrice-GQMD

    Energy Technology Data Exchange (ETDEWEB)

    Ramillien, V

    1995-07-01

    We present new experimental data obtained with the FOPI detector at the SIS Heavy ions accelerator (Darmstadt, Germany), for the Au + Au heavy ion collisions at 150 and 400 A.MeV incident energy. The sideward flow, determined form the method of Danielewicz without reaction plane reconstruction, and the nuclear stopping are studied as a function of the centrality of the collisions and as a function of the fragment charge. In order to study the nuclear in-medium effects, which act on the N-N cross-sections and potential and hence on experimental observables like the nuclear matter flow and stopping, these results are compared with the predictions of two different QMD versions. The first one (GQMD) offers a fully microscopic calculation of the cross-sections and potential in the G-matrix formalism and naturally includes the in-medium effects. This version is for the first time confronted to experiment. The second one (IQMD) uses a standard Skyrme potential plus a momentum dependent term in order to mimic the in-medium effects. We find that the experimental stopping is overestimated for 30-40% in the models IQMD and GQMD. Concerning the flow, we find that the momentum dependence of the potential in GQMD is somewhat stronger as can be seen for the more peripheral events and fits better the data in this case. On the other hand, the model GQMD clearly lacks of density dependence to reproduce the more central events. (author). 52 refs., 57 figs., 11 tabs.

  18. Looking beyond the exome: a phenotype-first approach to molecular diagnostic resolution in rare and undiagnosed diseases

    Science.gov (United States)

    Pena, Loren DM; Jiang, Yong-Hui; Schoch, Kelly; Spillmann, Rebecca C.; Walley, Nicole; Stong, Nicholas; Horn, Sarah Rapisardo; Sullivan, Jennifer A.; McConkie-Rosell, Allyn; Kansagra, Sujay; Smith, Edward C.; El-Dairi, Mays; Bellet, Jane; Ann Keels, Martha; Jasien, Joan; Kranz, Peter G.; Noel, Richard; Nagaraj, Shashi K.; Lark, Robert K.; Wechsler, Daniel SG; del Gaudio, Daniela; Leung, Marco L.; Hendon, Laura G.; Parker, Collette C.; Jones, Kelly L.; Goldstein, David B.; Shashi, Vandana

    2017-01-01

    Purpose To describe examples of missed pathogenic variants on whole exome sequencing (WES) and the importance of deep phenotyping for further diagnostic testing. Methods Guided by phenotypic information, three children with negative WES underwent targeted single gene testing. Results Individual 1 had a clinical diagnosis consistent with infantile systemic hyalinosis, although WES and an NGS-based ANTXR2 test were negative. Sanger sequencing of ANTXR2 revealed a homozygous single base pair insertion, previously missed by the WES variant caller software. Individual 2 had neurodevelopmental regression and cerebellar atrophy, with no diagnosis on WES. New clinical findings prompted Sanger sequencing and copy number testing of PLA2G6. A novel homozygous deletion of the non-coding exon 1 (not included in the WES capture kit) was detected, with extension into the promoter, confirming the clinical suspicion of infantile neuroaxonal dystrophy. Individual 3 had progressive ataxia, spasticity and MRI changes of vanishing white matter leukoencephalopathy. An NGS leukodystrophy gene panel and WES showed a heterozygous pathogenic variant in EIF2B5; no deletions/duplications were detected. Sanger sequencing of EIF2B5 showed a frameshift indel, likely missed due to failure of alignment. Conclusions These cases illustrate potential pitfalls of WES/NGS testing, and the importance of phenotype-guided molecular testing in yielding diagnoses. PMID:28914269

  19. De Novo Coding Variants Are Strongly Associated with Tourette Disorder

    DEFF Research Database (Denmark)

    Willsey, A Jeremy; Fernandez, Thomas V; Yu, Dongmei

    2017-01-01

    Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186 ...

  20. 75 FR 27227 - Energy Conservation Program: Energy Conservation Standards for Residential Central Air...

    Science.gov (United States)

    2010-05-14

    ...-7335. E-mail: Wes.Anderson@ee.doe.gov . Ms. Elizabeth Kohl, U.S. Department of Energy, Office of the... additional information regarding visiting the Resource Room. FOR FURTHER INFORMATION CONTACT: Mr. Wes Anderson, U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Building...

  1. World Englishes, English as an International Language and Applied Linguistics

    Science.gov (United States)

    Kilickaya, Ferit

    2009-01-01

    The paper discusses World Englishes (WEs) in relation to English as an International Language (EIL) and Applied Linguistics. Taking into account Kachru's interesting but at the same time controversial debate about the status of English in its varieties, which are commonly called WEs and the opposing ideas presented by Quirk, it is aimed to present…

  2. A clinical utility study of exome sequencing versus conventional genetic testing in pediatric neurology.

    Science.gov (United States)

    Vissers, Lisenka E L M; van Nimwegen, Kirsten J M; Schieving, Jolanda H; Kamsteeg, Erik-Jan; Kleefstra, Tjitske; Yntema, Helger G; Pfundt, Rolph; van der Wilt, Gert Jan; Krabbenborg, Lotte; Brunner, Han G; van der Burg, Simone; Grutters, Janneke; Veltman, Joris A; Willemsen, Michèl A A P

    2017-09-01

    Implementation of novel genetic diagnostic tests is generally driven by technological advances because they promise shorter turnaround times and/or higher diagnostic yields. Other aspects, including impact on clinical management or cost-effectiveness, are often not assessed in detail prior to implementation. We studied the clinical utility of whole-exome sequencing (WES) in complex pediatric neurology in terms of diagnostic yield and costs. We analyzed 150 patients (and their parents) presenting with complex neurological disorders of suspected genetic origin. In a parallel study, all patients received both the standard diagnostic workup (e.g., cerebral imaging, muscle biopsies or lumbar punctures, and sequential gene-by-gene-based testing) and WES simultaneously. Our unique study design allowed direct comparison of diagnostic yield of both trajectories and provided insight into the economic implications of implementing WES in this diagnostic trajectory. We showed that WES identified significantly more conclusive diagnoses (29.3%) than the standard care pathway (7.3%) without incurring higher costs. Exploratory analysis of WES as a first-tier diagnostic test indicates that WES may even be cost-saving, depending on the extent of other tests being omitted. Our data support such a use of WES in pediatric neurology for disorders of presumed genetic origin.Genet Med advance online publication 23 March 2017.

  3. Lynch syndrome patients' views of and preferences for return of results following whole exome sequencing.

    Science.gov (United States)

    Hitch, Kelly; Joseph, Galen; Guiltinan, Jenna; Kianmahd, Jessica; Youngblom, Janey; Blanco, Amie

    2014-08-01

    Whole exome sequencing (WES) uses next generation sequencing technology to provide information on nearly all functional, protein-coding regions in an individual's genome. Due to the vast amount of information and incidental findings that can be generated from this technology, patient preferences must be investigated to help clinicians consent and return results to patients. Patients (n = 19) who were previously clinically diagnosed with Lynch syndrome, but received uninformative negative Lynch syndrome genetic results through traditional molecular testing methods participated in semi-structured interviews after WES testing but before return of results to explore their views of WES and preferences for return of results. Analyses of interview results found that nearly all participants believed that the benefits of receiving all possible results generated from WES outweighed the undesirable effects. The majority of participants conveyed that relative to coping with a cancer diagnosis, information generated from WES would be manageable. Importantly, participants' experience with Lynch syndrome influenced their notions of genetic determinism, tolerance for uncertain results, and family communication plans. Participants would prefer to receive WES results in person from a genetic counselor or medical geneticist so that an expert could help explain the meaning and implications of the potentially large quantity and range of complicated results. These results underscore the need to study various populations with regard to the clinical use of WES in order to effectively and empathetically communicate the possible implications of this new technology and return results.

  4. The clinical utility of whole-exome sequencing in the context of rare diseases - the changing tides of medical practice.

    Science.gov (United States)

    Nguyen, M T; Charlebois, K

    2015-10-01

    Whole-exome sequencing (WES) carries the potential to facilitate the identification of disease causing genes. This is particularly relevant concerning rare diseases, which proves particularly difficult for physicians to diagnose. However, the complexity of this technology renders its applicability onto the clinical setting uncertain. Our study thus aims to understand physicians' perspectives regarding the clinical utility of WES, particularly for providing a diagnosis for patients with rare diseases. Ten semi-structured interviews were conducted with physicians with experience and familiarity with WES, and the major themes that emerged from our interviews were (i) the relevance of WES in diagnosing patients with rare diseases (appropriateness); (ii) the cost-effectiveness of WES (accessibility), (iii) the practical issues related to the clinical implementation of WES (practicability); and (iv) ethical, legal and social issues (acceptability). Our study highlights how the clinical implementation of WES presents additional challenges where rare diseases are taken into consideration. © 2014 The Authors. Clinical Genetics published by John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Establishing very long-chain fatty alcohol and wax ester biosynthesis in Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Wenning, Leonie; Yu, Tao; David, Florian

    2017-01-01

    used WEs are mainly isolated from Simmondsia chinensis (jojoba), but the high extraction costs and limited harvest areas constrain their use. The use of FARs in combination with different WSs to achieve a synthesis of jojoba-like WEs in bacteria and yeast has been reported previously, but the products...... were restricted to C28-C36 WEs. These rather short WEs make up only a very small percentage of the total WEs in natural jojoba oil. The synthesis of longer chain WEs (up to C44) in Saccharomyces cerevisiae has so far only been achieved after substrate feeding. Here we identified new routes......, respectively, after 48h. Moreover, we enabled the synthesis of jojoba-like WEs up to a chain length of C42, catalyzed by a combination of Maqu_2220 together with the WS from S. chinensis (SciWS) and the S. cerevisiae elongase Elo2p, with a maximum yield of 12.24±3.35mg/g CDW after 48h....

  6. Reporting results from whole-genome and whole-exome sequencing in clinical practice: a proposal for Canada?

    Science.gov (United States)

    Zawati, Ma'n H; Parry, David; Thorogood, Adrian; Nguyen, Minh Thu; Boycott, Kym M; Rosenblatt, David; Knoppers, Bartha Maria

    2014-01-01

    This article proposes recommendations for the use of whole-genome and whole-exome (WGS/WES) sequencing in clinical practice, endorsed by the board of directors of the Canadian College of Medical Geneticists. The publication of statements and recommendations by several international and national organisations on clinical WGS/WES has prompted a need for Canadian-specific guidance. A multi-disciplinary group consisting of lawyers, ethicists, genetic researchers, and clinical geneticists was assembled to review existing guidelines on WGS/WES and identify provisions relevant to the Canadian context. Definitions were provided to orient the recommendations and to minimize confusion with other recommendations. Recommendations include the following: WGS/WES should be used in a judicious and cost-efficient manner; WGS/WES should be used to answer a clinical question; and physicians need to explain to adult patients the nature of the results that could arise, so as to allow them to make informed choices over whether to take the test and which results they wish to receive. Recommendations are also provided for WGS/WES in the pediatric context, and for when results implicate patients' family members. These recommendations are only a proposal to be developed into comprehensive Canadian-based guidelines. They aim to promote discussion about the reporting of WGS/WES results, and to encourage the ethical implementation of these new technologies in the clinical setting.

  7. Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton Tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region

    NARCIS (Netherlands)

    Drabek, D.; Raguz, S.; Wit, de T.P.M.; Dingjan, G.M.; Savelkoul, H.F.J.; Grosveld, F.; Hendriks, R.W.

    1997-01-01

    Bruton tyrosine kinase (Btk) is essential for the development of pre-B cells to mature B cell stages. Btk-deficient mice manifest an X-linked immunodeficiency (xid) defect characterized by a reduction of peripheral IgMlow IgDhigh B cells, a lack of peritoneal CD5 B cells, low serum levels of IgM and

  8. Avaliação da experiência em EaD em um contexto de formação de formadores/Evaluation of Distance Education experience in a context of qualification of trainers

    Directory of Open Access Journals (Sweden)

    Heloisa Collins

    2009-06-01

    Full Text Available O objetivo deste artigo é analisar e discutir o que dizem sobre sua experiência em EAD alguns professores que vivenciaram um longo e exigente processo de formação continuada a distância. Para tanto, é apresentado um breve relato da experiência em EAD vivida pelos participantes do curso de formação continuada a distância Práticas de Leitura e Escrita na Contemporaneidade e oferecida uma interpretação de um conjunto de depoimentos de professores-alunos para tentar mostrar que processos de EAD podem, democraticamente, beneficiar diferentes tipos de alunos, gerar ótimos níveis de motivação para a aprendizagem e para o trabalho e oportunizar ricas relações humanas com alto grau de proximidade. A análise dos comentários dos alunos sobre sua aprendizagem e experiência digital faz uso de um aparato teórico proposto pela Linguística Sistêmico-Funcional. A interpretação dos depoimentos é então apoiada em uma análise da avaliatividade expressa na linguagem. Uma vez que realizamos avaliações para contar aos nossos ouvintes ou leitores como nos sentimos em relação a coisas ou pessoas, ou seja, que posições assumimos em relação a elas (Martin, 2003, é possível e importante tentar mapear os tipos de avaliações que os professores-alunos utilizam para falar de sua experiência, dos participantes e do curso. The aim of this paper is to analyze and discuss what some teachers say about a distance learning experience during a long and demanding distance teacher development process. To do this, we first present a report on the experience in the teacher development course Práticas de Leitura e Escrita na Contemporaneidade (Reading and Writing Practices in Contemporaneity; then, we offer an interpretation about a set of evaluative reports the participants made. Our aim is to argue that distance courses can be democratically beneficial to different types of students, motivating for work and study and an opportunity for the creation of rich human relations, with a high degree of proximity. The analysis of the evaluative reports makes use of theoretical tools offered by Systemic Functional Linguistics, more specifically appraisal theory (Martin 2003. Since we make evaluations in order to tell our interlocutors about how we feel in relation to people and things, i.e., what positions we assume in relation to them, it is possible to try and map the types of evaluations that the participants make to talk about their experience, about their colleagues and about the course.

  9. Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration

    NARCIS (Netherlands)

    Vallejo-Vaz, Antonio J.; Akram, Asif; Kondapally Seshasai, Sreenivasa Rao; Cole, Della; Watts, Gerald F.; Hovingh, G. Kees; Kastelein, John J. P.; Mata, Pedro; Raal, Frederick J.; Santos, Raul D.; Soran, Handrean; Freiberger, Tomas; Abifadel, Marianne; Aguilar-Salinas, Carlos A.; Alnouri, Fahad; Alonso, Rodrigo; Al-Rasadi, Khalid; Banach, Maciej; Bogsrud, Martin P.; Bourbon, Mafalda; Bruckert, Eric; Car, Josip; Ceska, Richard; Corral, Pablo; Descamps, Olivier; Dieplinger, Hans; Do, Can T.; Durst, Ronen; Ezhov, Marat V.; Fras, Zlatko; Gaita, Dan; Gaspar, Isabel M.; Genest, Jaques; Harada-Shiba, Mariko; Jiang, Lixin; Kayikcioglu, Meral; Lam, Carolyn S. P.; Latkovskis, Gustavs; Laufs, Ulrich; Liberopoulos, Evangelos; Lin, Jie; Lin, Nan; Maher, Vincent; Majano, Nelson; Marais, A. David; März, Winfried; Mirrakhimov, Erkin; Miserez, André R.; Mitchenko, Olena; Nawawi, Hapizah; Nilsson, Lennart; Nordestgaard, Børge G.; Paragh, György; Petrulioniene, Zaneta; Pojskic, Belma; Reiner, Željko; Sahebkar, Amirhossein; Santos, Lourdes E.; Schunkert, Heribert; Shehab, Abdullah; Slimane, M. Naceur; Stoll, Mario; Su, Ta-Chen; Susekov, Andrey; Tilney, Myra; Tomlinson, Brian; Tselepis, Alexandros D.; Vohnout, Branislav; Widén, Elisabeth; Yamashita, Shizuya; Catapano, Alberico L.; Ray, Kausik K.

    2016-01-01

    Background: The potential for global collaborations to better inform public health policy regarding major non-hypercholesterolaemia (FH), a common genetic disorder associated with premature cardiovascular disease, is yet to be reliably ascertained using similar approaches. The European

  10. Using Paraquat to Generate Anion Free Radicals and Hydrogen Peroxide in "In Vitro": Antioxidant Effect of Vitamin E--A Procedure to Teach Theoretical and Experimental Principles of Reactive Oxygen Species Biochemistry

    Science.gov (United States)

    Jimenez-Del-Rio, Marlene; Suarez-Cedeno, Gerson; Velez-Pardo, Carlos

    2010-01-01

    The theoretical basis of reactive oxygen species and their impact on health issues are relatively easy to understand by biomedical students. The detection of reactive oxygen species requires expensive equipment, the procedures are time consuming and costly, and the results are hard to interpret. Moreover, cause-and-effect relationships in the…

  11. ‘How movies move us just the right way’ - Exploring the role of camera movement and montage in human film perception - First steps on a joint venture of 4EA approaches to cognition and empirical Neuroscience

    OpenAIRE

    Heimann, Katrin

    2015-01-01

    Film is an omnipresent medium in today’s world, playing a crucial role in a massive amusement industry, in advertisement as well as in information distribution, education, sciences and the arts. What and how we perceive the world when we perceive it via film thus seems an important question to answer. Still, the principles of film perception are barely understood. This thesis presents some of the newest steps in an interdisciplinary approach to exploring human creation and perception of film....

  12. Universidades que ofertam cursos EaD no estado de Santa Catarina: uma comparaçâo entre o nível de maturidade e o índice potencial de maturidade

    Directory of Open Access Journals (Sweden)

    Cleide Tirana Nunes Possamai

    2017-12-01

    Full Text Available Em virtude de sua constante evolução, a Educação a Distância tornou-se um tema de intensas pesquisas, afinal o objetivo desta modalidade de ensino é facilitar o acesso à população a aperfeiçoamento constate, principalmente pela utilização frequente de novas tecnologias e sua modernização, consolidando-se desta forma como uma opção que a população encontra para se atualizar. Este estudo tem por objetivo comparar o nível de maturidade e o índice potencial de maturidade nas instituições de ensino que ofertam cursos em EAD no Estado de Santa Catarina. Para atingir este objetivo utilizou-se um modelo de maturidade adaptado para as características deste segmento. Por meio de uma pesquisa quantitativa, descrita, de corte transversal e método survey, os dados deste estudo foram obtidos. O tratamento destes dados concretizou-se por meio da moda. A tabulação foi efetuada para identificar o NM e o IPM de cada IES buscando realizar a devida comparação. Os achados da pesquisa apresentam o nível de maturidade e o índice potencial de maturidade de cada IES, bem como a comparação entre ambos para verificar se existe um nível de maturidade que seja ideal para as Universidades de Santa Catarina que ofertam cursos em EAD.

  13. FLDAS Noah Land Surface Model L4 daily 0.1 x 0.1 degree for Eastern Africa (GDAS and RFE2) V001 (FLDAS_NOAH01_A_EA_D) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains a series of land surface parameters simulated from the Noah 3.3 model in the Famine Early Warning Systems Network (FEWS NET) Land Data...

  14. Verification of k (0)-NAA results at the LVR-15 reactor in A similar to eA3/4 with the use of Au plus Mo plus Rb( plus Zn) monitor set

    Czech Academy of Sciences Publication Activity Database

    Kubešová, Marie; Krausová, Ivana; Kučera, Jan

    2014-01-01

    Roč. 300, č. 2 (2014), s. 473-480 ISSN 0236-5731 R&D Projects: GA ČR(CZ) GBP108/12/G108; GA MŠk(XE) LM2011019 Institutional support: RVO:61389005 Keywords : neutron activation analysis * k(0) standardization * neutron flux parameters * monitor set for long irradiations Subject RIV: CB - Analytical Chemistry , Separation Impact factor: 1.034, year: 2014

  15. Case note: HvJ EU (rolnummer C-160/14: João Filipe Ferreira da Silva e Brito e.a. tegen Estado português)

    NARCIS (Netherlands)

    Beltzer, R.M.

    2015-01-01

    AIA, een Portugese luchtvaartmaatschappij, is ontbonden en de werknemers zijn ontslagen. TAP, de hoofdaandeelhouder van AIA, is gedurende een half jaar een deel van de vluchten van AIA gaan uitvoeren, waaronder chartervluchten. Op deze markt was TAP nog niet actief. De Portugese rechter vraagt in

  16. Research on the Port Strategic Alliance of the Coastal Ar-eas of Zhejiang Province%浙江省沿海港口战略联盟研究

    Institute of Scientific and Technical Information of China (English)

    林伟泓

    2014-01-01

    随着竞争的日趋激烈,港口企业逐渐认识到进行合作的重要性和必要性,在竞合的过程中实现互赢,港口战略联盟就是在这种背景下发生的。本文介绍了港口战略联盟的概念、内容以及部分已经开始探索港口联盟的浙江港口企业的发展现状,并介绍港口战略联盟的主要联盟方式---横向战略联盟和纵向战略联盟,结合浙江港口实际状况,探求其中所存在的问题,并针对其提出了一些较具体的解决方案,以供浙江港口企业参考。%With the competition becoming increasingly fierce, port enterprises have gradually realized the importance and necessity of cooperation, and they mutually benefit from the competition and cooperation, so port strategic alliance emerges in the back-ground. This paper introduced the definition and content of port strategic alliance, as well as the development situation of some Zhejiang port enterprises which have already started exploring port alliance, and also introduced the main ways of alliance-transverse strategic alliance and longitudinal strategic alliance. Combined with the practical situation of Zhejiang port, this paper explored the existing problems and provided some specific solu-tions for Zhejiang port enterprises.

  17. Guidelines, "minimal requirements" and standard of care in glioblastoma around the Mediterranean Area: A report from the AROME (Association of Radiotherapy and Oncology of the Mediterranean arEa) Neuro-Oncology working party.

    Science.gov (United States)

    2016-02-01

    Glioblastoma is the most common and the most lethal primary brain tumor in adults. Although studies are ongoing, the epidemiology of glioblastoma in North Africa (i.e. Morocco, Algeria and Tunisia) remains imperfectly settled and needs to be specified for a better optimization of the neuro-oncology healthcare across the Mediterranean area and in North Africa countries. Over the last years significant therapeutic advances have been accomplished improving survival and quality of life of glioblastoma patients. Indeed, concurrent temozolomide-radiotherapy (temoradiation) and adjuvant temozolomide has been established as the standard of care associated with a survival benefit and a better outcome. Therefore, considering this validated strategy and regarding the means and some other North Africa countries specificities, we decided, under the auspices of AROME (association of radiotherapy and oncology of the Mediterranean area; www.aromecancer.org), a non-profit organization, to organize a dedicated meeting to discuss the standards and elaborate a consensus on the "minimal requirements" adapted to the local resources. Thus, panels of physicians involved in daily multidisciplinary brain tumors management in the two borders of the Mediterranean area have been invited to the AROME neuro-oncology working party. We report here the consensus, established for minimal human and material resources for glioblastoma diagnosis and treatment faced to the standard of care, which should be reached. If the minimal requirements are not reached, the patients should be referred to the closest specialized medical center where at least minimal requirements, or, ideally, the standard of care should be guaranteed to the patients. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  18. Muusikamaailm : Sibeliuse nädal Järvenpääl. Enescu festival Bukarestis. Ukraina tagastab käsikirjad. Nello Santi 70. Gina Cigna lahkus kõrges eas / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    Järvenpääl toimus Sibeliuse nädal. Bukarestis toimus George Enescu festival. Ukraina valitsuse otsusega tagastatakse Berliini Gesangsakademie'le nende fondides olnud hulk käsikirjalis Nimekas itaalia ooperidirigent Nello Santi sai 70. Itaalia päritolu prantsuse ooperilaulja Gina Cigna suri 101 aastasena

  19. FLDAS Noah Land Surface Model L4 Monthly Climatology 0.1 x 0.1 degree for Eastern Africa (MERRA-2 and CHIRPS) V001 (FLDAS_NOAH01_C_EA_MC) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — The monthly climatology data set contains a series of land surface parameters simulated from the Noah 3.3 model in the Famine Early Warning Systems Network (FEWS...

  20. Does Late Gadolinium Enhancement still have Value? Right Ventricular Internal Mechanical Work, Ea/Emax and Late Gadolinium Enhancement as Prognostic Markers in Patients with Advanced Pulmonary Hypertension via Cardiac MRI.

    Science.gov (United States)

    Abouelnour, Amr Ei; Doyle, Mark; Thompson, Diane V; Yamrozik, June; Williams, Ronald B; Shah, Moneal B; Soma, Siva Kr; Murali, Srinivas; Benza, Raymond L; Biederman, Robert Ww

    2017-01-01

    Investigate the impact of Right Ventricular (RV) Internal Work (IW), ratio of arterial to ventricular end-systolic elastance (E a /E max ), and RV Insertion Point (IP) Late Gadolinium Enhancement (LGE) on outcome in Pulmonary Hypertension (PH) patients. LGE is well known to be present within the RVIPs and Inter Ventricular Septum (IVS) in PH patients, but its prognostic role remains complex and potentially overestimated via 2D qualitative relative to the 3D quantitative measures now available. However, E a /E max , a measure of ventricular-arterial coupling and IW, when added to external cardiac work i.e. the P-V loop area as correlates to the heart's energy demands, might fundamentally improve measures of prognosis as they interrogate physiology beyond just the RV. Cardiac Magnetic Resonance Imaging (CMR) of 124 PH patients (age = 60±13, 85F) referred to a large tertiary PH center, was retrospectively examined for RV volumetric and functional indices and RVIP LGE%. Right Heart Catheterizations (RHC) performed within 1±2 months of the CMR were reviewed. E a /E max was derived as RV End-Systolic Volume (ESV/RVSV). IW was estimated as RVESV ×(RV end-systolic pressure-RV diastolic pressure). Patients were followed from date of CMR for up to 5 years for MACE (death, hospitalized RV failure, initiation of parenteral prostacyclin, sustained ventricular arrhythmia or referral for lung transplantation). MACE was high; 48/124 (39%) patients had MACE by 1.6±1.3 years. Neither RVIP nor IVS LGE using visual assessment or even 3D quantization predicted MACE. The strongest predictor of MACE was RVIW (OR=1.00013, pright-sided human myocardial pathologies.

  1. Efeito do NaCI sobre o crecimento ea multiplicação in vitro de bananeira The effect of NaCl on the growth and multiplication of bananeira (MUSA SP in vitro

    Directory of Open Access Journals (Sweden)

    Cristiane Elizabeth Costa de Macêdo

    2005-08-01

    Full Text Available A salinidade dos solos é um importante fator de estresse, ocorrendo em regiões semi-áridas e áridas do Nordeste brasileiro, onde a bananeira é cultivada. O efeito de diferentes concentrações de cloreto de sódio (NaCl foi estudado sobre a multiplicação e o crescimento in vitro de brotos de bananeira da variedade "Grand Naine", visando a uma posterior seleção in vitro. Brotos de bananeira foram inoculados em meio de cultura MS (Murashige & SKoog na ausência de T0=0 (controle e na presença de três tratamentos contendo NaCl: T1= 50mM; T2=75mM e T3=100mM e subcultivados cinco vezes nos seus respectivos tratamentos. Os subcultivos foram realizados a cada 30 dias e observado o número de brotos multiplicados por broto inoculado em cada tratamento, a altura e o número de folhas dos brotos inoculados e a produção de matéria fresca aos 0; 30; 60; 90; 120 e 150 dias após a exposição ao sal. Os resultados mostraram que a adição de NaCl ao meio de cultura afetou a multiplicação in vitro, e que o aumento da concentração do sal é proporcional à diminuição do número de brotos produzidos. A multiplicação in vitro de brotos de bananeira foi reduzida em cerca de 80% na dose de 50mM e em cerca de 90% nas doses de 75 e 100mM. Nos tratamentos submetidos a 75 e 100 mM de NaCl, houve redução do número de folhas e também no crescimento dos brotos iniciais e na produção de matéria fresca. A melhor dose de NaCl entre as testadas e sob as condições experimentais utilizadas, para a realização de uma posterior seleção, foi 50mM por ter apresentado efeitos intermediários nos caracteres avaliados.Soil salinity is an important factor of stress that occurs in many semi-arid and arid regions of Brazil where the bananeira is cultivated. The effect of different sodium chloride (NaCl concentrations, in vitro, on the growth and shoot multiplication derived from explants of "Grand Naine" variety was studied. The shoot-tips of the bananeira were inoculated in MS media in the absence: T0=0 (control and in the presence of three NaCl treatments: T1=50mM, T2=75mM e T3=100mM and sub cultured five times in the respective treatments. The subcultures were carried out every 30 days and the number of shoots multiplicated on each inoculated shoot, length and total number leaves of inoculated shoot and production of fresh weight were observed at 0; 30; 60; 90; 120 e 150 days after salt exposition. The results showed that the presence of NaCl in the media affects the shoot's production in vitro. The increase of NaCl concentration in the media is proportional to the decrease in the number of shoots produced. The multiplication of bananeira's shoot reduced about 80% in the treatment T1, while the treatments T2 and T3 achieved 90% of reduction. On the other hand the two saline treatments 75 and 100 mM interfered at the same form in the growth of shoots, production of fresh weight, length and total number of leaves. Under experimental conditions the best dose among the different sodium chloride was 50 mM because this dose showed intermediary effects on the characters evaluated.

  2. Exclusive measurements of light fragment production at forward angles in Ne-Pb and Ne-NaF collisions at E/A=400 MeV and 800 MeV

    International Nuclear Information System (INIS)

    Bastid, N.; Alard, J.P.; Arnold, J.; Augerat, J.; Biagi, F.; Crouau, M.; Charmensat, P.; Dupieux, P.; Fraysse, L.; Marroncle, J.; Montarou, G.; Parizet, M.J.; Qassoud, D.; Rahmani, A.; Schimmerling, W.

    1990-01-01

    Emission of light fragments at small angles is studied in relativistic heavy ion collisions using the Diogene plastic wall for both symmetrical and non-symmetrical target-projectile systems with 400 MeV per nucleon and 800 MeV per nucleon incident neon nuclei. Efficiency of multiplicity measurements in the small angle range for the selection of central or peripheral collisions is confirmed for asymmetric systems. Differential production cross sections of Z=1 fragments show evidence for the existence of two emitting sources. The apparent temperature of each source is obtained from comparison with a thermodynamical model. (orig.)

  3. Final Environmental Assessment and Finding of No Significant Impact (EA/FONSI) for 2012-14 Capital Improvements Program (CIP) at Davis-Monthan Air Force Base, Tucson, Arizona

    Science.gov (United States)

    2012-03-01

    million years ago. Isolated outcrops of granite more than 1 billion years old are evident throughout the province, but most of the andesite and basaltic ...billion years ago (U.S. Geological Survey 2003). Some basaltic flows occurred as early as 4 million years ago and as late as 65 million years ago...hazardous fibers released into the air. Buildings to be demolished or renovated should be evaluated for the presence of ACMs or other hazardous

  4. Fighting the Flu

    Centers for Disease Control (CDC) Podcasts

    2011-03-08

    Wes Studi, Hollywood actor, urges Native peoples to know the facts about the flu.  Created: 3/8/2011 by National Center for Immunization and Respiratory Diseases (NCIRD).   Date Released: 3/8/2011.

  5. kardinale aspekte van nasionale diensplig met spesifieke verwysing ...

    African Journals Online (AJOL)

    This is the case with organizations such as the. South African ..... Federale Republiek van Wes-Duitsland: The Force Structure in the. Federal Republic of ... Defense Intelligence Agency& Arms and Armour Press, Londen1979, p 121. 8.

  6. Initial Earthquake Centrifuge Model Experiments for the Study of Liquefaction

    National Research Council Canada - National Science Library

    Steedman, R

    1998-01-01

    .... These are intended to gather data suitable for the development of improved design approaches for the prediction of liquefaction under earthquake loading using the new centrifuge facility at the WES...

  7. Hazardous Waste Research Center

    Data.gov (United States)

    Federal Laboratory Consortium — The U.S. Army Engineer Waterways Experiment Station (WES) is playing a major role in development of technologies for cleanup of toxic and hazardous waste in military...

  8. Options for In Situ Capping of Palos Verdes Shelf Contaminated Sediments

    National Research Council Canada - National Science Library

    Palermo, Michael; Schroeder, Paul; Rivera, Yilda; Ruiz, Carlos; Clarke, Doug; Gailani, Joe; Clausner, James; Hynes, Mary; Fredette, Thomas; Tardy, Barbara

    1999-01-01

    The U.S. Army Engineer Waterways Experiment Station (WES) has performed an evaluation of in situ capping options for sediment restoration of DDT and PCB contaminated sediments on the Palos Verdes (PV...

  9. Identification of genetic defects in primary immunodeficiencies by whole exome sequencing

    DEFF Research Database (Denmark)

    Christiansen, Mette; Jensen, Jens Magnus Bernth; Veirum, Jens Erik

    2014-01-01

    to hypogammaglobulinaemia, and increased risk of both infections as well as cancer. We employed whole exome sequencing (WES) to identify mutations associated with primary immunodeficiency in severely affected children. We present WES data on 2 patients with severe immunodeficiency. WES was performed using TruSeq exome kit...... and severe infections including sepsis. Second, we identified compound heterozygote stopgain mutations in RAD52 and a heterozygote mutation in LRRC8A in a 7 year-old girl with T-cell deficiency, reduced T-cell mediated B-cell activity, hypogammaglobulinaemia, prolonged splenomegali and benign adenopathy. RAD......52 has not previously been linked to immunodeficiency and we are currently investigating the functional consequences. Knowledge of the mechanisms underlying immunodeficiencies is a prerequisite for understanding disease pathogenesis. WES allows the demonstration of immune defects that may result from...

  10. 76 FR 39245 - Energy Conservation Program: Energy Conservation Standards for Residential Furnaces and...

    Science.gov (United States)

    2011-07-06

    ... Wes.Anderson@ee.doe.gov . Mr. Eric Stas or Ms. Jennifer Tiedeman, U.S. Department of Energy, Office of.... Wesley Anderson (central air conditioners and heat pumps), U.S. Department of Energy, Office of Energy...

  11. Evaluation and comparison of health care Work Environment Scale in military settings.

    Science.gov (United States)

    Maloney, J P; Anderson, F D; Gladd, D L; Brown, D L; Hardy, M A

    1996-05-01

    The purpose of this study was to describe health care providers' perceptions of their work environment at a large U.S. Army medical center, and to compare the findings to other military medical centers. The sample (N = 112) consisted of the professional nursing staff working on the nine inpatient units. The Work Environmental Scale (WES) was used to measure perceptions of the workplace relative to gender, position (head nurses, staff nurses, and agency nurses), specialty nursing (intensive care unit [ICU] versus non-ICU), education (MSN, BSN, and ADN), and patterns of differences between the WES subscales of four military medical centers. Results of the study indicate that there were no significant gender differences. Head nurses, non-ICU nurses, and MSN nurses perceived their environment more positively. There were significant differences in the WES subscales between the military hospitals. Implications for nursing using the WES were recommended.

  12. Petrus Abelardus se Megariaanse argument in Theologia 'Scholarium'

    African Journals Online (AJOL)

    Test

    7 Jun 2011 ... Martin Heidegger se beroemde opmerking (1958:37; 'Die wêreld word donker . .... Luther en die Wes-Europese Kerkhervorming}]). 7. ...... King, P., 2004, 'Peter Abelard', Stanford Encyclopedia of Philosophy, viewed February.

  13. The Induction of Growth Inhibition and Apoptosis in HeLa and MCF-7 Cells by Teucrium sandrasicum, Having Effective Antioxidant Properties.

    Science.gov (United States)

    Tarhan, Leman; Nakipoğlu, Mahmure; Kavakcıoğlu, Berna; Tongul, Burcu; Nalbantsoy, Ayşe

    2016-03-01

    The hidromethanolic (Met/W), ethyl acetate (EA(EA/W)), and water (W(EA/W)) extracts from Teucrium sandrasicum leaves (L) and flowers (F) were investigated for antioxidant properties and antiproliferative effects on HeLa, MCF-7, and L929. The highest DPPH scavenging, metal chelating capacities, and total phenolic and flavonoid contents were observed in Met/WL. The highest hydroxyl scavenging and reducing power capacities were found in EA(EA/W)L. Met/WL, EA(EA/W)L and EA(EA/W)F inhibited cancer cell growths, while they did not show significant cytotoxicity on L929. While the reactive oxygen species (ROS) levels were generally close to controls in HeLa, they were induced in MCF-7 with the treatment of Met/WL, EA(EA/W)L, and EA(EA/W)F and acted as antioxidant for L929. The highest apoptosis inductions were observed in Met/WL-treated HeLa and EA(EA/W)L-treated MCF-7, which were supported with the changes in mitochondrial membrane potentials. The highest caspase-9 activities were found in Met/WL-treated HeLa and EA(EA/W)F-treated MCF-7. Caspase-3 activity was only induced in EA(EA/W)F-treated HeLa.

  14. 75 FR 28002 - Duke Energy Indiana, Inc.; Notice of Intent To Prepare an Environmental Assessment for the...

    Science.gov (United States)

    2010-05-19

    .... The main goal of the scoping process is to focus the analysis in the EA on the important environmental... the EA. All comments received in a timely fashion will be considered during the preparation of the EA...

  15. Evaluation of Upland Disposal of Oakland Harbor, California, Sediment; Volume I: Turning Basin Sediments

    Science.gov (United States)

    1992-10-01

    infiltration studies ( Westerdahl and Skogerboe 1982). Extensive field 53 verification studies have been conducted with the WES Rainfall Simulator...Lysimeter System on a wide range of Corps project sites ( Westerdahl and Skogerboe 1982, Lee and Skogerboe 1984, Skogerboe et al. 1987). The WES Rain- fall...Vicksburg, MS. Winer, B. J. 1971. Statistical Principles in Experimental Design, McGraw- Hill Book Company, New York. Westerdahl , H. E., and Skogerboe, J

  16. Aquatic Plant Control Research Program. Proceedings, Annual Meeting, Aquatic Plant Control Research Program (23rd) Held in West Palm Beach, Florida on 14-17 November 1988

    Science.gov (United States)

    1989-06-01

    85 CHEMICAL CONTROL TECHNOLOGY DEVELOPMENT .......... 91 Chemical Control Technology Development: Overview by Howard E. Westerdahl ...A, B, & C) Chemical Convod Technlo Development - H. Westerdah, WES, Presiding 8:00 a.m. Overview - Chemical Control Technology -H. Westerdahl , WES 8...Paul PO Box 631 1421 USPO & Custom House Vicksburg, MS 39181-0631 St. Paul, MN 55101-1479 Howard Westerdahl Tim Worley USAE Waterways Experiment Station

  17. New Bedford Harbor Superfund Project, Acushnet River Estuary Engineering Feasibility Study of Dredging and Dredged Material Disposal Alternatives. Report 4. Surface Runoff Quality Evaluation for Confined Disposal

    Science.gov (United States)

    1988-01-01

    infiltration studies ( Westerdahl and Skogerboe 1982). Exten- sive field verification studies have been conducted with the WES Rainfall Simulator...Lysimeter System on a wide range of USACE project sites ( Westerdahl and Skogerboe 1982, Lee and Skogerboe 1984, Skogerboe et al. 1987). The WES Rainfall...Criteria for Water 1986,"’ Criteria and Standards Division, Washington, DC. Westerdahl , H. E., and Skogerboe, J. G. 1982. "Realistic Rainfall and Water

  18. Esthetic evaluation of maxillary single-tooth implants in the esthetic zone

    Science.gov (United States)

    Cho, Hae-Lyung; Lee, Jae-Kwan; Um, Heung-Sik

    2010-01-01

    Purpose The aim of this study is to assess the influence exerted by the observer's dental specialization and compare patients' opinion with observers' opinion of the esthetics of maxillary single-tooth implants in the esthetic zone. Methods Forty-one adult patients, who were treated with a single implant in the esthetic zone, were enrolled in this study. Eight observers (2 periodontists, 2 prosthodontists, 2 orthodontists and 2 senior dental students) applied the pink esthetic score (PES)/white esthetic score (WES) to 41 implant-supported single restorations twice with an interval of 4 weeks. We used a visual analog scale (VAS) to assess the patient's satisfaction with the treatment outcome from an esthetic point of view. Results In the PES/WES, very good and moderate intraobserver agreements were noted between the first and second rating. The mean total PES/WES was 11.19 ± 3.59. The mean PES was 5.17 ± 2.29 and mean WES was 6.02 ± 1.96. In the total PES/WES, the difference between the groups was not significant. However, in the WES, the difference between the groups was significant and prosthodontists were found to have assigned poorer ratings than the other groups. Periodontists gave higher ratings than prosthodontists and senior dental students. Orthodontists were clearly more critical than the other observers. The statistical analysis revealed statistically significant correlation between patients' esthetic perception and dentists' perception of the anterior tooth. However, the correlation between the total PES/WES and the VAS score for the first premolar was not statistically significant. Conclusions The PES/WES is an objective tool in rating the esthetics of implant supported single crowns and adjacent soft tissues. Orthodontists were the most critical observers, while periodontists were more generous than other observers. The statistical analysis revealed a statistically significant correlation between patients' esthetic perception and dentists

  19. Establishing very long-chain fatty alcohol and wax ester biosynthesis in Saccharomyces cerevisiae.

    Science.gov (United States)

    Wenning, Leonie; Yu, Tao; David, Florian; Nielsen, Jens; Siewers, Verena

    2017-05-01

    Wax esters (WEs) are neutral lipids and can be used for a broad range of commercial applications, including personal care products, lubricants, or coatings. They are synthesized by enzymatic reactions catalyzed by a fatty acyl reductase (FAR) and a wax ester synthase (WS). At present, commercially used WEs are mainly isolated from Simmondsia chinensis (jojoba), but the high extraction costs and limited harvest areas constrain their use. The use of FARs in combination with different WSs to achieve a synthesis of jojoba-like WEs in bacteria and yeast has been reported previously, but the products were restricted to C28-C36 WEs. These rather short WEs make up only a very small percentage of the total WEs in natural jojoba oil. The synthesis of longer chain WEs (up to C44) in Saccharomyces cerevisiae has so far only been achieved after substrate feeding. Here we identified new routes for producing very long-chain fatty alcohols (VLCFOHs) up to a chain length of C22 by heterologous expression of a FAR derived from Apis mellifera (AmFAR1) or Marinobacter aquaeolei VT8 (Maqu_2220) in S. cerevisiae and achieved maximum yields of 3.22 ± 0.36 mg/g cell dry weight (CDW) and 7.84 ± 3.09 mg/g CDW, respectively, after 48 h. Moreover, we enabled the synthesis of jojoba-like WEs up to a chain length of C42, catalyzed by a combination of Maqu_2220 together with the WS from S. chinensis (SciWS) and the S. cerevisiae elongase Elo2p, with a maximum yield of 12.24 ± 3.35 mg/g CDW after 48 h. Biotechnol. Bioeng. 2017;114: 1025-1035. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  20. Interagency Research Conference (15th) Held in Vicksburg, Mississippi on 3-5 November 1987

    Science.gov (United States)

    1987-11-05

    Stepped Spillway USBR H-7b Labyrinth Spillways USBR H-7d Scour Downstream from Stilling Basins WES H-Ba Analyses of Hydroturbine Vibrations TVA H-Be... Hydroturbine Flow Measurement Using the Pressure- Time Method TVA The following technology transfer methods were given by the participants: a. Technical...7c Stilling Basin Damage Due to Erosion USBR H-7d Scour Downstream from Stilling Basins WES H-8a Analyses of Hydroturbine Vibrations TVA H-8b

  1. Borehole Plugging-Materials Development Program

    International Nuclear Information System (INIS)

    Gulick, C.W. Jr.

    1978-06-01

    This report discusses the background and first year's results of the grouting materials development program for plugging boreholes associated with the Nuclear Waste Isolation Pilot Plant. The grouts are to be pumpable, impermeable, and durable for many thousands of years. The work was done at the Concrete Laboratory of the U.S. Army Engineer Waterways Experiment Station (WES), Vicksburg, Mississippi. The workability, strength, porosity, bonding, expansion, and permeability data are summarized and discussed. The work is continuing at WES

  2. Cloning, production, and functional expression of the bacteriocin enterocin A, produced by Enterococcus faecium T136, by the yeasts Pichia pastoris, Kluyveromyces lactis, Hansenula polymorpha, and Arxula adeninivorans.

    Science.gov (United States)

    Borrero, Juan; Kunze, Gotthard; Jiménez, Juan J; Böer, Erik; Gútiez, Loreto; Herranz, Carmen; Cintas, Luis M; Hernández, Pablo E

    2012-08-01

    The bacteriocin enterocin A (EntA) produced by Enterococcus faecium T136 has been successfully cloned and produced by the yeasts Pichia pastoris X-33EA, Kluyveromyces lactis GG799EA, Hansenula polymorpha KL8-1EA, and Arxula adeninivorans G1212EA. Moreover, P. pastoris X-33EA and K. lactis GG799EA produced EntA in larger amounts and with higher antimicrobial and specific antimicrobial activities than the EntA produced by E. faecium T136.

  3. A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders.

    Science.gov (United States)

    Stark, Zornitza; Tan, Tiong Y; Chong, Belinda; Brett, Gemma R; Yap, Patrick; Walsh, Maie; Yeung, Alison; Peters, Heidi; Mordaunt, Dylan; Cowie, Shannon; Amor, David J; Savarirayan, Ravi; McGillivray, George; Downie, Lilian; Ekert, Paul G; Theda, Christiane; James, Paul A; Yaplito-Lee, Joy; Ryan, Monique M; Leventer, Richard J; Creed, Emma; Macciocca, Ivan; Bell, Katrina M; Oshlack, Alicia; Sadedin, Simon; Georgeson, Peter; Anderson, Charlotte; Thorne, Natalie; Melbourne Genomics Health Alliance; Gaff, Clara; White, Susan M

    2016-11-01

    To prospectively evaluate the diagnostic and clinical utility of singleton whole-exome sequencing (WES) as a first-tier test in infants with suspected monogenic disease. Singleton WES was performed as a first-tier sequencing test in infants recruited from a single pediatric tertiary center. This occurred in parallel with standard investigations, including single- or multigene panel sequencing when clinically indicated. The diagnosis rate, clinical utility, and impact on management of singleton WES were evaluated. Of 80 enrolled infants, 46 received a molecular genetic diagnosis through singleton WES (57.5%) compared with 11 (13.75%) who underwent standard investigations in the same patient group. Clinical management changed following exome diagnosis in 15 of 46 diagnosed participants (32.6%). Twelve relatives received a genetic diagnosis following cascade testing, and 28 couples were identified as being at high risk of recurrence in future pregnancies. This prospective study provides strong evidence for increased diagnostic and clinical utility of singleton WES as a first-tier sequencing test for infants with a suspected monogenic disorder. Singleton WES outperformed standard care in terms of diagnosis rate and the benefits of a diagnosis, namely, impact on management of the child and clarification of reproductive risks for the extended family in a timely manner.Genet Med 18 11, 1090-1096.

  4. Designing Efficient Self-Diagnosis Activities in the Physics Classroom

    Science.gov (United States)

    Safadi, Rafi'

    2017-12-01

    Self-diagnosis (SD) activities require students to self-diagnose their solutions to problems that they solved on their own. This involves identifying where they went wrong and then explaining the nature of their errors—why they went wrong—aided by some form of support. Worked examples (WEs) are often used to support students in SD activities. A WE is a step-by-step demonstration of how to solve a problem. One unresolved issue is why students fail to exploit WEs in SD exercises. Yerushalmi et al., for instance, provided students with written WEs and asked them to self-diagnose their solutions with respect to these WEs. These authors found no correlation between students' SD performance and their subsequent problem-solving performance on transfer problems, suggesting that students had only superficially exploited the written WEs. The aim of this article is to describe a new SD activity that was developed to prompt students to effectively use written WEs when self-diagnosing, and to examine its effectiveness in advancing students' learning in physics.

  5. Genetic counselors' views and experiences with the clinical integration of genome sequencing.

    Science.gov (United States)

    Machini, Kalotina; Douglas, Jessica; Braxton, Alicia; Tsipis, Judith; Kramer, Kate

    2014-08-01

    In recent years, new sequencing technologies known as next generation sequencing (NGS) have provided scientists the ability to rapidly sequence all known coding as well as non-coding sequences in the human genome. As the two emerging approaches, whole exome (WES) and whole genome (WGS) sequencing, have started to be integrated in the clinical arena, we sought to survey health care professionals who are likely to be involved in the implementation process now and/or in the future (e.g., genetic counselors, geneticists and nurse practitioners). Two hundred twenty-one genetic counselors- one third of whom currently offer WES/WGS-participated in an anonymous online survey. The aims of the survey were first, to identify barriers to the implementation of WES/WGS, as perceived by survey participants; second, to provide the first systematic report of current practices regarding the integration of WES/WGS in clinic and/or research across the US and Canada and to illuminate the roles and challenges of genetic counselors participating in this process; and third to evaluate the impact of WES/WGS on patient care. Our results showed that genetic counseling practices with respect to WES/WGS are consistent with the criteria set forth in the ACMG 2012 policy statement, which highlights indications for testing, reporting, and pre/post test considerations. Our respondents described challenges related to offering WES/WGS, which included billing issues, the duration and content of the consent process, result interpretation and disclosure of incidental findings and variants of unknown significance. In addition, respondents indicated that specialty area (i.e., prenatal and cancer), lack of clinical utility of WES/WGS and concerns about interpretation of test results were factors that prevented them from offering this technology to patients. Finally, study participants identified the aspects of their professional training which have been most beneficial in aiding with the integration of

  6. Developing and Implementing "Waupaca Eating Smart": A Restaurant and Supermarket Intervention to Promote Healthy Eating Through Changes in the Food Environment.

    Science.gov (United States)

    Escaron, Anne L; Martinez-Donate, Ana P; Riggall, Ann Josie; Meinen, Amy; Hall, Beverly; Nieto, F Javier; Nitzke, Susan

    2016-03-01

    Restaurants and food stores are suitable settings for healthy eating interventions. A community-academic partnership developed and implemented "Waupaca Eating Smart" (WES), a healthy eating program in restaurants and supermarkets of a rural, Midwest community. Previous interventions targeted either restaurants or small food stores nearly all in urban areas. Intervention design and implementation is rarely documented, making replication difficult for interested researchers and communities. In this article, we report the activities we undertook to develop and implement WES. Working with a local nutrition and activity coalition, we used evidence-based strategies guided by the social ecological model and social marketing principles to inform the content of WES. Formative assessment included a review of the literature, statewide key informant interviews and focus groups with restaurant and food store operators and patrons, a local community survey, and interviews with prospective WES businesses. WES was implemented in seven restaurants and two supermarkets and evaluated for feasibility and acceptance using surveys and direct observation of WES implementation. Prior to this intervention, only one of seven restaurants had three or more meals that met WES nutrition criteria. By the end of the program, 38 meals were labeled and promoted to restaurant customers, and the team had staffed four side salad taste tests for supermarket customers. Four and 10 months after intervention launch, the majority of the program's strategies were observed in participating outlets, suggesting that these program's strategies are feasible and can be sustained. Operators reported strong satisfaction overall. A combined restaurant- and supermarket-based healthy eating intervention is feasible and positively valued in rural communities. Further research is needed to better understand how to foster sustainability of these interventions and their impact on customer food choices. © 2015 Society for

  7. Whole exome sequencing in neurogenetic odysseys: An effective, cost- and time-saving diagnostic approach.

    Directory of Open Access Journals (Sweden)

    Marta Córdoba

    Full Text Available Diagnostic trajectories for neurogenetic disorders frequently require the use of considerable time and resources, exposing patients and families to so-called "diagnostic odysseys". Previous studies have provided strong evidence for increased diagnostic and clinical utility of whole-exome sequencing in medical genetics. However, specific reports assessing its utility in a setting such as ours- a neurogeneticist led academic group serving in a low-income country-are rare.To assess the diagnostic yield of WES in patients suspected of having a neurogenetic condition and explore the cost-effectiveness of its implementation in a research group located in an Argentinean public hospital.This is a prospective study of the clinical utility of WES in a series of 40 consecutive patients selected from a Neurogenetic Clinic of a tertiary Hospital in Argentina. We evaluated patients retrospectively for previous diagnostic trajectories. Diagnostic yield, clinical impact on management and economic diagnostic burden were evaluated.We demonstrated the clinical utility of Whole Exome Sequencing in our patient cohort, obtaining a diagnostic yield of 40% (95% CI, 24.8%-55.2% among a diverse group of neurological disorders. The average age at the time of WES was 23 (range 3-70. The mean time elapsed from symptom onset to WES was 11 years (range 3-42. The mean cost of the diagnostic workup prior to WES was USD 1646 (USD 1439 to 1853, which is 60% higher than WES cost in our center.WES for neurogenetics proved to be an effective, cost- and time-saving approach for the molecular diagnosis of this heterogeneous and complex group of patients.

  8. Hartley and Itokawa: small comet and asteroid with similar morphologies and structures

    Science.gov (United States)

    Kochemasov, G. G.

    2011-10-01

    at the convex bulge, from the antipodean side (Fig. 5). The smaller rocky asteroid Itokawa (0.5 km long, Fig. 2) is surprisingly similar in shape and structure to the icy core of Hart ley. It is also bent and rich in cross-cutting lineations o 4 direct ions marked by small holes-craters. But here they are ext inct and lack of gas -dust jets. One sees a transition from a volat ile rich comet core to an ext inct mostly rocky mass - asteroid. In both cases (comet core and as teroid) in the middle develops a smooth "wais t". The bulged convex and antipodal concave segments -hemispheres in rotating bodies require somewhat different densities of composing them masses to equilibrate angular momentum of two halves (compare with the Ea rth's hemis pheres : the eas tern continental "granitic" and wes tern Pacific "bas altic"). The near-IR images of two asteroids (Fig.6-7) confirm this. The concave and convex s ides are co mpos itionally d ifferent. In the Eros ' cas e the concave s ide is rich er in pyroxene, thus denser.

  9. Diagnostic Impact and Cost-effectiveness of Whole-Exome Sequencing for Ambulant Children With Suspected Monogenic Conditions.

    Science.gov (United States)

    Tan, Tiong Yang; Dillon, Oliver James; Stark, Zornitza; Schofield, Deborah; Alam, Khurshid; Shrestha, Rupendra; Chong, Belinda; Phelan, Dean; Brett, Gemma R; Creed, Emma; Jarmolowicz, Anna; Yap, Patrick; Walsh, Maie; Downie, Lilian; Amor, David J; Savarirayan, Ravi; McGillivray, George; Yeung, Alison; Peters, Heidi; Robertson, Susan J; Robinson, Aaron J; Macciocca, Ivan; Sadedin, Simon; Bell, Katrina; Oshlack, Alicia; Georgeson, Peter; Thorne, Natalie; Gaff, Clara; White, Susan M

    2017-09-01

    Optimal use of whole-exome sequencing (WES) in the pediatric setting requires an understanding of who should be considered for testing and when it should be performed to maximize clinical utility and cost-effectiveness. To investigate the impact of WES in sequencing-naive children suspected of having a monogenic disorder and evaluate its cost-effectiveness if WES had been available at different time points in their diagnostic trajectory. This prospective study was part of the Melbourne Genomics Health Alliance demonstration project. At the ambulatory outpatient clinics of the Victorian Clinical Genetics Services at the Royal Children's Hospital, Melbourne, Australia, children older than 2 years suspected of having a monogenic disorder were prospectively recruited from May 1 through November 30, 2015, by clinical geneticists after referral from general and subspecialist pediatricians. All children had nondiagnostic microarrays and no prior single-gene or panel sequencing. All children underwent singleton WES with targeted phenotype-driven analysis. The study examined the clinical utility of a molecular diagnosis and the cost-effectiveness of alternative diagnostic trajectories, depending on timing of WES. Of 61 children originally assessed, 44 (21 [48%] male and 23 [52%] female) aged 2 to 18 years (mean age at initial presentation, 28 months; range, 0-121 months) were recruited, and a diagnosis was achieved in 23 (52%) by singleton WES. The diagnoses were unexpected in 8 of 23 (35%), and clinical management was altered in 6 of 23 (26%). The mean duration of the diagnostic odyssey was 6 years, with each child having a mean of 19 tests and 4 clinical genetics and 4 nongenetics specialist consultations, and 26 (59%) underwent a procedure while under general anesthetic for diagnostic purposes. Economic analyses of the diagnostic trajectory identified that WES performed at initial tertiary presentation resulted in an incremental cost savings of A$9020 (US$6838) per

  10. Simulating (log(c) n)-wise Independence in NC

    Science.gov (United States)

    1989-05-01

    independent) distribution. However, Xk (A) = (1x(I))k = Z Z y (i,)...X(ik). iEA ijEAi 2 EA IkEA So Lemma 2.4 applies to show that any k-wise independent...AEA AEAi1EA ikEA So henceforth we want an X such that F(X) >_ E[F(X)]. 2.5 Generating k-Wise Independent Variables It still remains to demonstrate a k

  11. Esthetic Evaluation of Implant Crowns and Peri-Implant Soft Tissue in the Anterior Maxilla: Comparison and Reproducibility of Three Different Indices.

    Science.gov (United States)

    Tettamanti, Sandro; Millen, Christopher; Gavric, Jelena; Buser, Daniel; Belser, Urs C; Brägger, Urs; Wittneben, Julia-Gabriela

    2016-06-01

    A successful implant reconstruction with optimal esthetics consists of a visually pleasing prosthesis and complete and healthy surrounding soft tissue. In the current literature, numerous indices used to qualitatively assess esthetics have been described. However, studies comparing the indices and their reproducibility are scarce. The aim of this study was to compare three different esthetic indices for the evaluation of single implant-supported crowns. A total of 10 prosthodontists (P), 10 orthodontists (O), 10 general dentists (G), and 10 lay people (L) independently performed the same assessment using 30 photographs and corresponding casts with three different esthetic indices (Peri-Implant and Crown Index [PICI], Implant Crown Aesthetic Index [ICAI], "Pink Esthetic Score/White Esthetic Score [PES/WES]) and repeated the evaluations 4 weeks later. The PES/WES and the PICI showed significantly higher esthetic scores (pink, white, total) and clinical acceptance compared with the ICAI in all four groups and in both assessments. The highest intraobserver agreement was achieved using the PES/WES and the least with the ICAI. The mean Kappa per group ranged from 0.18 (group L with ICAI) to 0.63 (group G with PICI). In comparison with the ICAI, the PES/WES and PICI were more reproducible. Therefore, PES/WES and PICI seem to be more suitable as esthetic indices for single implant crowns. © 2015 Wiley Periodicals, Inc.

  12. Genotyping of fanconi anemia patients by whole exome sequencing: advantages and challenges.

    Directory of Open Access Journals (Sweden)

    Kerstin Knies

    Full Text Available Fanconi anemia (FA is a rare genomic instability syndrome. Disease-causing are biallelic mutations in any one of at least 15 genes encoding members of the FA/BRCA pathway of DNA-interstrand crosslink repair. Patients are diagnosed based upon phenotypical manifestations and the diagnosis of FA is confirmed by the hypersensitivity of cells to DNA interstrand crosslinking agents. Customary molecular diagnostics has become increasingly cumbersome, time-consuming and expensive the more FA genes have been identified. We performed Whole Exome Sequencing (WES in four FA patients in order to investigate the potential of this method for FA genotyping. In search of an optimal WES methodology we explored different enrichment and sequencing techniques. In each case we were able to identify the pathogenic mutations so that WES provided both, complementation group assignment and mutation detection in a single approach. The mutations included homozygous and heterozygous single base pair substitutions and a two-base-pair duplication in FANCJ, -D1, or -D2. Different WES strategies had no critical influence on the individual outcome. However, database errors and in particular pseudogenes impose obstacles that may prevent correct data perception and interpretation, and thus cause pitfalls. With these difficulties in mind, our results show that WES is a valuable tool for the molecular diagnosis of FA and a sufficiently safe technique, capable of engaging increasingly in competition with classical genetic approaches.

  13. Promises, pitfalls and practicalities of prenatal whole exome sequencing.

    Science.gov (United States)

    Best, Sunayna; Wou, Karen; Vora, Neeta; Van der Veyver, Ignatia B; Wapner, Ronald; Chitty, Lyn S

    2018-01-01

    Prenatal genetic diagnosis provides information for pregnancy and perinatal decision-making and management. In several small series, prenatal whole exome sequencing (WES) approaches have identified genetic diagnoses when conventional tests (karyotype and microarray) were not diagnostic. Here, we review published prenatal WES studies and recent conference abstracts. Thirty-one studies were identified, with diagnostic rates in series of five or more fetuses varying between 6.2% and 80%. Differences in inclusion criteria and trio versus singleton approaches to sequencing largely account for the wide range of diagnostic rates. The data suggest that diagnostic yields will be greater in fetuses with multiple anomalies or in cases preselected following genetic review. Beyond its ability to improve diagnostic rates, we explore the potential of WES to improve understanding of prenatal presentations of genetic disorders and lethal fetal syndromes. We discuss prenatal phenotyping limitations, counselling challenges regarding variants of uncertain significance, incidental and secondary findings, and technical problems in WES. We review the practical, ethical, social and economic issues that must be considered before prenatal WES could become part of routine testing. Finally, we reflect upon the potential future of prenatal genetic diagnosis, including a move towards whole genome sequencing and non-invasive whole exome and whole genome testing. © 2017 John Wiley & Sons, Ltd. © 2017 John Wiley & Sons, Ltd.

  14. Identification of innate immunodeficiencies by whole genome sequencing

    DEFF Research Database (Denmark)

    Mogensen, Trine; Christiansen, Mette; Veirum, Jens Erik

    2014-01-01

    encephalitis or other herpes simplex virus (HSV) disease manifestations. The goal is to identify host factors in innate immunity which may explain the hitherto unknown mechanism underlying differential susceptibility to HSV infections between individuals. Such knowledge may have clinical and therapeutical...... implications. Methods: As part of a pilot study we performed WES on 4 patients with herpes encephalitis or mucocutaneous manifestations of HSV infection. WES was performed with Illumina technology (Illumina HiSeq/MiSeq) and analyzed PolyPhen-2 (Polymorphism Phenotyping v2) PhyloP, and SIFT prediction software......, TBK1 and Unc93B) may contribute to the development of herpes encephalitis. Common to these genetic defects is that they lead to reduced antiviral interferon (IFN) responses. In this study whole exome sequencing (WES) was performed to identify mutations associated with susceptibility to herpes...

  15. Whole-exome sequencing links TMCO1 defect syndrome with cerebro-facio-thoracic dysplasia.

    Science.gov (United States)

    Pehlivan, Davut; Karaca, Ender; Aydin, Hatip; Beck, Christine R; Gambin, Tomasz; Muzny, Donna M; Bilge Geckinli, B; Karaman, Ali; Jhangiani, Shalini N; Gibbs, Richard A; Lupski, James R

    2014-09-01

    Whole-exome sequencing (WES) is a type of disruptive technology that has tremendous influence on human and clinical genetics research. An efficient and cost-effective method, WES is now widely used as a diagnostic tool for identifying the molecular basis of genetic syndromes that are often challenging to diagnose. Here we report a patient with a clinical diagnosis of cerebro-facio-thoracic dysplasia (CFTD; MIM#213980) in whom we identified a homozygous splice-site mutation in the transmembrane and coiled-coil domains 1 (TMCO1) gene using WES. TMCO1 mutations cause craniofacial dysmorphism, skeletal anomalies characterized by multiple malformations of the vertebrae and ribs, and intellectual disability (MIM#614132). A retrospective review revealed that clinical manifestations of both syndromes are very similar and overlap remarkably. We propose that mutations of TMCO1 are not only responsible for craniofacial dysmorphism, skeletal anomalies and mental retardation syndrome but also for CFTD.

  16. Electroacupuncture at Zusanli Prevents Severe Scalds-Induced Gut Ischemia and Paralysis by Activating the Cholinergic Pathway

    Directory of Open Access Journals (Sweden)

    Huan Wang

    2015-01-01

    Full Text Available Severe burn injuries may result in gastrointestinal paralysis, and barrier dysfunction due to gut ischemia and lowered vagus excitability. In this study we investigate whether electroacupuncture (EA at Zusanli (ST36 could prevent severe scalds-induced gut ischemia, paralysis, and barrier dysfunction and whether the protective role of EA at ST36 is related to the vagus nerve. 35% burn area rats were divided into six groups: (a EAN: EA nonchannel acupoints followed by scald injury; (b EA: EA at ST36 after scald injury; (c VGX/EA: vagotomy (VGX before EA at ST36 and scald injury; (d VGX/EAN: VGX before EAN and scald injury; (e atropine/EA: applying atropine before scald injury and then EA at ST36; (f atropine/EAN: applying atropine before scald injury and then EA at nonchannel acupoints. EA at the Zusanli point significantly promoted the intestinal impelling ratio and increased the amount of mucosal blood flow after scald injury. The plasma diamine oxidase (DAO and intestinal permeability decreased significantly after scald injury in the EA group compared with others. However, EA after atropine injection or cervical vagotomy failed to improve intestinal motility and mucosa blood flow suggesting that the mechanism of EA may be related to the activation of the cholinergic nerve pathway.

  17. Alkaline water electrolysis technology for Space Station regenerative fuel cell energy storage

    Science.gov (United States)

    Schubert, F. H.; Hoberecht, M. A.; Le, M.

    1986-01-01

    The regenerative fuel cell system (RFCS), designed for application to the Space Station energy storage system, is based on state-of-the-art alkaline electrolyte technology and incorporates a dedicated fuel cell system (FCS) and water electrolysis subsystem (WES). In the present study, emphasis is placed on the WES portion of the RFCS. To ensure RFCS availability for the Space Station, the RFCS Space Station Prototype design was undertaken which included a 46-cell 0.93 cu m static feed water electrolysis module and three integrated mechanical components.

  18. Whole-exome sequencing analysis of Waardenburg syndrome in a Chinese family

    Science.gov (United States)

    Chen, Dezhong; Zhao, Na; Wang, Jing; Li, Zhuoyu; Wu, Changxin; Fu, Jie; Xiao, Han

    2017-01-01

    Waardenburg syndrome (WS) is a dominantly inherited, genetically heterogeneous auditory-pigmentary syndrome characterized by non-progressive sensorineural hearing loss and iris discoloration. By whole-exome sequencing (WES), we identified a nonsense mutation (c.598C>T) in PAX3 gene, predicted to be disease causing by in silico analysis. This is the first report of genetically diagnosed case of WS PAX3 c.598C>T nonsense mutation in Chinese ethnic origin by WES and in silico functional prediction methods. PMID:28690861

  19. Ontwikkelingsekonomie — Bestek en metode vir die studie daarvan

    Directory of Open Access Journals (Sweden)

    H.J. Weber

    1974-03-01

    Full Text Available Kennis van die probleme van onderontwikkelde gebiede is baie oud. Sodra verskille in ontwikkeldheid, hetsy op militêre, ekonomiese of ander gebiede duidelik word, en as sodanig erken word, wys die probleme van die minderontwikkelde gebiede hulself uit. Die ekonomiese geskiedenis is vol sodanige erkende verskille o.a. Hellenistiese kultuursentra, Imperiale Rome, Byzantium en sy florerende stadstaat; Noord- en Wes- Europa na die ontdekking van die nuwe wêreld en die vasstelling van effektiewe marinekommunikasie tussen Wes- Europa, Amerika en Oos-Asië.

  20. Whole-exome sequencing analysis of Waardenburg syndrome in a Chinese family.

    Science.gov (United States)

    Chen, Dezhong; Zhao, Na; Wang, Jing; Li, Zhuoyu; Wu, Changxin; Fu, Jie; Xiao, Han

    2017-01-01

    Waardenburg syndrome (WS) is a dominantly inherited, genetically heterogeneous auditory-pigmentary syndrome characterized by non-progressive sensorineural hearing loss and iris discoloration. By whole-exome sequencing (WES), we identified a nonsense mutation (c.598C>T) in PAX3 gene, predicted to be disease causing by in silico analysis. This is the first report of genetically diagnosed case of WS PAX3 c.598C>T nonsense mutation in Chinese ethnic origin by WES and in silico functional prediction methods.

  1. HABP2 p.G534E variant in patients with family history of thyroid and breast cancer

    DEFF Research Database (Denmark)

    Pinheiro, Maísa; Drigo, Sandra Aparecida; Tonhosolo, Renata

    2017-01-01

    Familial Papillary Thyroid Carcinoma (PTC) has been described as a hereditary predisposition cancer syndrome associated with mutations in candidate genes including HABP2. Two of 20 probands from families with history of PTC and breast carcinoma (BC) were evaluated by whole exome sequencing (WES...... familial PTC cases. Genes potentially associated with deregulation of the extracellular matrix organization pathway (CTSB, TNXB, COL4A3, COL16A1, COL24A1, COL5A2, NID1, LOXL2, MMP11, TRIM24 and MUSK) and DNA repair function (NBN and MSH2) were detected by WES, suggesting that other cancer-associated genes...

  2. Die Ontstaan en Ontwikkeling van die Pan-Afrikanisme en due implikasies daarvan

    Directory of Open Access Journals (Sweden)

    A. J.H. van der Walt

    1961-03-01

    Full Text Available Dit was nie voor 1880 dat tropiese Afrika, dil is die grootste gedeelte van Wes-, Oos- en Midde-Afrika, deur ontdekkingsreisigers,handelaars en sendelinge tot so ’11 mate ontsluit is, dat dit in die vaarwater van die wêreldpolitiek geraak het nie. Lank voor hierdie tyd is natuurlik steunpunte aan die Wes-, Suid- en Ooskusdeur die Portugese en later die Nederlanders en Engelse eset ter wille van óf dieslawehandel en/óf as steunpunte op dielarig handelsweg na die ryke Ooste.

  3. Coinheritance of biallelic SLURP1 and SLC39A4 mutations cause a severe genodermatosis with skin peeling and hair loss all over the body.

    Science.gov (United States)

    Harms, F L; Nampoothiri, S; Kortüm, F; Thomas, J; Panicker, V V; Alawi, M; Altmüller, J; Yesodharan, D; Kutsche, K

    2018-06-27

    Next-generation sequencing (NGS), especially multi-gene panels and whole-exome sequencing (WES), is a tool for identifying the cause of monogenic disorders and has played a role in uncovering the genetic cause of previously uncharacterized genodermatoses. 1 By the application of NGS, the concept of apparently novel or atypical clinical presentations has been challenged by the finding of two or more genetic diagnoses in affected individuals. Approximately 5% of cases in which WES was informative had dual or multiple molecular diagnoses. 2 This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  4. Standardization of laboratory lipid profile assessment: A call for action with a special focus on the 2016 ESC/EAS dyslipidemia guidelines - Executive summary: A consensus endorsed by the Cardiovascular Risk and Prevention Group of the Portuguese Internal Medicine Society, the Portuguese Atherosclerosis Society, the Portuguese Society of Cardiology, the Portuguese Society of Laboratory Medicine, and the Portuguese Association of Clinical Chemistry.

    Science.gov (United States)

    da Silva, Pedro Marques; Sequeira Duarte, João; von Hafe, Pedro; Gil, Victor; Nunes de Oliveira, Jorge; de Sousa, Germano

    2018-04-01

    Even with improvements in lifestyle interventions, better control of cardiovascular (CV) risk factors, and improvements in CV outcomes, cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in Portugal and Europe. Atherogenic dyslipidemias, particularly hypercholesterolemia, have a crucial causal role in the development of atherosclerotic CVD. The clinical approach to a patient with dyslipidemia requires an accurate diagnosis, based on harmonized and standardized lipid and lipoprotein laboratory assessments. Results and reports of these tests, together with assessment of total CV risk and the respective therapeutic targets, will help ensure that clinical guidelines and good clinical practices are followed, increasing the reliability of screening for lipid disorders, producing more accurate diagnoses and CV risk stratification, and improving CV prevention. To this end, this consensus aims to provide clinicians with practical guidance for the harmonization and standardization of laboratory lipid tests, focusing on the most recent dyslipidemia management guidelines. Copyright © 2018 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.

  5. Combined Endometrial Ablation and Levonorgestrel Intrauterine System Use in Women With Dysmenorrhea and Heavy Menstrual Bleeding: Novel Approach for Challenging Cases.

    Science.gov (United States)

    Papadakis, Efstathios P; El-Nashar, Sherif A; Laughlin-Tommaso, Shannon K; Shazly, Sherif A M; Hopkins, Matthew R; Breitkopf, Daniel M; Famuyide, Abimbola O

    2015-01-01

    To evaluate the feasibility and impact of levonorgestrel intrauterine system (LNG-IUS) on treatment failure after endometrial ablation (EA) in women with heavy menstrual bleeding (HMB) and dysmenorrhea at 4 years. Cohort study (Canadian Task Force II-2). An academic institution in the upper Midwest. All women with HMB and dysmenorrhea who underwent EA with combined placement of LNG-IUS (EA/LNG-IUS cohort, 23 women) after 2005 and an historic reference group from women who had EA alone (EA cohort, 65 women) from 1998 through the end of 2005. Radiofrequency EA, thermal balloon ablation, and LNG-IUS. The primary outcome was treatment failure defined as persistent pain, bleeding, and hysterectomy after EA at 4 years. The combined treatment failure outcome was documented in 2 patients (8.7%) in the EA/LNG-IUS group and 19 patients (29.2%) in the EA group with an unadjusted OR of .23 (95% CI, .05-1.08). After adjusting for known risk factors of failure, the adjusted OR was .19 (95% CI, .26-.88). None of the women who underwent EA/LNG-IUS had hysterectomy for treatment failure compared with 16 (24%) in the EA group (p = .009); postablation pelvic pain was documented in 1 woman (4.3%) in the EA/LNG-IUS group compared with 8 women (12.3%) in the EA group (p = .24). One woman in the EA/LNG-IUS group (4.3%) presented with persistent bleeding compared with 15 (23.1%) in the EA group (p = .059). Office removal of the intrauterine device was performed in 4 women with no complications. LNG-IUS insertion at the time of EA is feasible and can provide added benefit after EA in women with dysmenorrhea and HMB. Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved.

  6. Practitioner survey of the state of health integration in environmental assessment: The case of northern Canada

    International Nuclear Information System (INIS)

    Noble, Bram; Bronson, Jackie

    2006-01-01

    Based on a case study of health integration in Canadian northern EA, this paper further demonstrates the lack of consistent integration of health in EA practice. A survey was administered to northern EA and health practitioners, administrators and special interest groups to assess current northern health assessment practices, the scope of health in EA, EA performance with regard to health assessment and the perceived barriers to health integration. Results suggest that health is currently recognized as an important component of northern EA and is addressed in the majority of cases; however, health is addressed primarily during the pre-decision stages of EA and less often during post-decision follow-up and monitoring. Moreover, when health is addressed, attention is limited to the physical components of health and health impacts due to physical environmental change, with considerably less attention given to the social aspects of health. Results also suggest dissent between EA practitioners, health practitioners and other interests concerning the overall state of health in EA; however, there is consensus on the key challenges to improved integration, namely differences in understanding of the scope of health and expectations of EA to assess health impacts; limited coordination between EA and health practitioners; limited scope and requirements of current EA legislation for health assessment; and the lack of supporting EA methods and frameworks

  7. Environmental assessment in The Netherlands: Effectively governing environmental protection? A discourse analysis

    Energy Technology Data Exchange (ETDEWEB)

    Runhaar, Hens, E-mail: h.a.c.runhaar@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Laerhoven, Frank van, E-mail: vanLaerhoven@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Driessen, Peter, E-mail: p.driessen@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Arts, Jos, E-mail: e.j.m.m.arts@rug.nl [University of Groningen, Faculty of Planning, P.O. Box 800, 9700 AV Groningen (Netherlands)

    2013-02-15

    Environmental assessment (EA) aims to enhance environmental awareness and to ensure that environmental values are fully considered in decision-making. In the EA arena, different discourses exist on what EA should aim for and how it functions. We hypothesise that these discourses influence its application in practice as well as its effectiveness in terms of achieving the above goals. For instance, actors who consider EA as a hindrance to fast implementation of their projects will probably apply it as a mandatory checklist, whereas actors who believe that EA can help to develop more environmentally sound decisions will use EIA as a tool to design their initiatives. In this paper we explore discourses on EA in The Netherlands and elaborate on their implications for EA effectiveness. Based on an innovative research design comprising an online survey with 443 respondents and 20 supplementary semi-structured interviews we conclude that the dominant discourse is that EA is mainly a legal requirement; EAs are conducted because they have to be conducted, not because actors choose to do so. EA effectiveness however seems reasonably high, as a majority of respondents perceive that it enhances environmental awareness and contributes to environmental protection. However, the 'legal requirement' discourse also results in decision-makers seldom going beyond what is prescribed by EA and environmental law. Despite its mandatory character, the predominant attitude towards EA is quite positive. For most respondents, EA is instrumental in providing transparency of decision-making and in minimising the legal risks of not complying with environmental laws. Differences in discourses seldom reflect extreme opposites. The 'common ground' regarding EA provides a good basis for working with EA in terms of meeting legal requirements but at the same time does not stimulate creativity in decision-making or optimisation of environmental values. In countries characterised by

  8. Environmental assessment in The Netherlands: Effectively governing environmental protection? A discourse analysis

    International Nuclear Information System (INIS)

    Runhaar, Hens; Laerhoven, Frank van; Driessen, Peter; Arts, Jos

    2013-01-01

    Environmental assessment (EA) aims to enhance environmental awareness and to ensure that environmental values are fully considered in decision-making. In the EA arena, different discourses exist on what EA should aim for and how it functions. We hypothesise that these discourses influence its application in practice as well as its effectiveness in terms of achieving the above goals. For instance, actors who consider EA as a hindrance to fast implementation of their projects will probably apply it as a mandatory checklist, whereas actors who believe that EA can help to develop more environmentally sound decisions will use EIA as a tool to design their initiatives. In this paper we explore discourses on EA in The Netherlands and elaborate on their implications for EA effectiveness. Based on an innovative research design comprising an online survey with 443 respondents and 20 supplementary semi-structured interviews we conclude that the dominant discourse is that EA is mainly a legal requirement; EAs are conducted because they have to be conducted, not because actors choose to do so. EA effectiveness however seems reasonably high, as a majority of respondents perceive that it enhances environmental awareness and contributes to environmental protection. However, the ‘legal requirement’ discourse also results in decision-makers seldom going beyond what is prescribed by EA and environmental law. Despite its mandatory character, the predominant attitude towards EA is quite positive. For most respondents, EA is instrumental in providing transparency of decision-making and in minimising the legal risks of not complying with environmental laws. Differences in discourses seldom reflect extreme opposites. The ‘common ground’ regarding EA provides a good basis for working with EA in terms of meeting legal requirements but at the same time does not stimulate creativity in decision-making or optimisation of environmental values. In countries characterised by less

  9. Abikäsi miljardite liigutajatele / Kadri Jakobson ; kommenteerinud Paavo Põld, Juhan Parts

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2010-01-01

    Varahaldusettevõtted Limestone Investment Management, Redgate Asset Management ja Avaron Asset Management on saanud EAS-ilt eksporditoetusi kokku 5,4 mln. krooni, kuid pole teada, millele täpselt raha kulub. EAS-i selgitusi

  10. An investigation into the perceptions of business stakeholders on the benefits of enterprise architecture: the case of Telkom SA

    CSIR Research Space (South Africa)

    Lehong, SM

    2013-06-01

    Full Text Available This study identifies the perceived benefits of Enterprise Architecture (EA) among business stakeholders who are aware of EA but are not specialists in the field of ICT, and proposes a clearly differentiated and comprehensive cluster of stakeholder...

  11. A brief dietary assessment predicts executive dysfunction in an elderly cohort: results from the Einstein Aging Study

    Science.gov (United States)

    Objectives: To examine the association between diet and executive function, episodic memory and global verbal cognition in the Einstein Aging Study (EAS) cohort and determine whether race modifies this relationship. Design: Cross-sectional. Setting: Community. Participants: EAS participants without ...

  12. National Manpower Inventory. Volume 3. Technical Documentation for Software for the Model

    Science.gov (United States)

    1985-09-01

    Radar & AXR-13 LLLTV IMA Technician Drone Electronics Technician EA-6a EXCAP Central Computer ( AYA -6) Technician EA-6B EXCAP DTS Opor & ALO-99 Displays...7196 AM 7212 AM 7222 AM 7223 Tllla DTS Operator & Digital Display Group IMA Technician EA-6B ICAP Central Computer AYA -6 Technician EA-3B OMA...Personnel Clerk 0131 Unit Diary Clerk 0151 Administrative Clerk 0161 Postal Clerk 0193 Personnel/Administrative Chief 0211 Counlefinlelligence

  13. Autonomous Reconfiguration Procedures for EJB-based Enterprise Applications

    OpenAIRE

    Vogel, Thomas; Bruhn, Jens; Wirtz, Guido

    2018-01-01

    Enterprise Applications (EA) are complex software systems for supporting the business of companies. Evolution of an EA should not affect its availability, e.g., because of a temporal shutdown, business operations may be affected. One possibility to address this problem is the seamless reconfiguration of the affected EA, i.e., applying the relevant changes while the system is running. Our approach to seamless reconfiguration focuses on component-oriented EAs. It is based on the Autonomic Compu...

  14. Electroacupuncture Ameliorates Learning and Memory via Activation of the CREB Signaling Pathway in the Hippocampus to Attenuate Apoptosis after Cerebral Hypoperfusion

    OpenAIRE

    Han, Xiaohua; Zhao, Xiuxiu; Lu, Min; Liu, Fang; Guo, Feng; Zhang, Jinghui; Huang, Xiaolin

    2013-01-01

    Studies have shown that electroacupuncture (EA) ameliorates learning and memory after ischemic injury. However, there have been few studies elucidating the mechanisms of EA on learning and memory in cerebral hypoperfusion. In this study, we explored the cAMP response element-binding protein (CREB) signaling pathway-mediated antiapoptotic action involved in EA-induced improvement of learning and memory. EA at GV20 and GV14 acupoints was applied in cerebral hypoperfusion rats. A Morris water ma...

  15. Dietary enzymatically treated Artemisia annua L. supplementation alleviates liver oxidative injury of broilers reared under high ambient temperature

    Science.gov (United States)

    Wan, Xiaoli; Zhang, Jingfei; He, Jintian; Bai, Kaiwen; Zhang, Lili; Wang, Tian

    2017-09-01

    Heat stress induced by high ambient temperature is a major concern in commercial broiler production. To evaluate the effects of dietary enzymatically treated Artemisia annua L. (EA) supplementation on growth performance and liver oxidative injury of broilers reared under heat stress, a total of 320 22-day-old male broilers were randomly allotted into five groups with eight replicates of eight birds each. Broilers in the control group were housed at 22 ± 1 °C and fed the basal diet. Broilers in the HS, HS-EA1, HS-EA2, and HS-EA3 groups were fed basal diet supplemented with 0, 0.75, 1.00, and 1.25 g/kg EA, respectively, and reared under cyclic high temperature (34 ± 1 °C for 8 h/day and 22 ± 1 °C for 16 h/day). Broilers fed EA diets had higher final body weight, average daily body weight gain, and average daily feed intake, as well as liver concentration of reduced glutathione, activities of antioxidant enzymes, abilities to inhibit hydroxyl radical and superoxide radical (HS-EA2 and HS-EA3), and lower liver concentrations of reactive oxygen metabolites, malondialdehyde, and protein carbonyl (HS-EA1, HS-EA2, and HS-EA3) than HS group ( P proteins 70 and 90, upregulated the mRNA levels of nuclear factor erythroid 2-related factor 2 (HS-EA1, HS-EA2, and HS-EA3) and heme oxygenase 1 (HS-EA2 and HS-EA3) in liver of heat-treated broilers ( P diet is 1.00-1.25 g/kg.

  16. Long-term pulmonary function in esophageal atresia-A case-control study

    DEFF Research Database (Denmark)

    Pedersen, Rikke N; Markøv, Simone; Kruse-Andersen, Søren

    2017-01-01

    BACKGROUND: Esophageal atresia (EA) is a congenital anomaly associated with substantial pulmonary morbidity throughout childhood. AIM: The aim of this study was to evaluate pulmonary complications among 59 five to 15-year-old children and adolescents with surgically corrected congenital EA. METHO...... ventilatory impairment occurring in EA is probably due to poor lung growth after thoracotomy. No single factor predicted ventilatory impairment in children and adolescents with EA. Pediatr Pulmonol. 2016; 9999:XX-XX. © 2016 Wiley Periodicals, Inc....

  17. The Reintegration of Tongan Postgraduate Scholars after Study Abroad: Knowledge Utilisation and Resituation

    Science.gov (United States)

    Franken, Margaret; Langi, Nautalus Tuituiovai Kaho; Branson, Christopher

    2016-01-01

    Higher education has seen increasing educational mobility as students finance themselves or get financial support from their families to study abroad (Shields "Comp Educ Rev" 57(4):609-636, 2013; Verbik and Lazanowski in "World education news and reviews." http://www.wes.org/educators/pdf/StudentMobility.pdf, 2007). Another…

  18. Abiotic and Biotic Mechanisms Controlling In Situ Remediation of NDMA

    Science.gov (United States)

    2009-05-01

    1985; Mitch et al. 2003) and soil microcosms ( Mallik and Testai 1981). These results were confirmed in our laboratory (WES) using 14C-NDMA (Figure...9- Fluorenylmethylchloroformate.” Journal of Chromatography 721(2):231–239. Mallik MA and K Testai. 1981. “Transformation of Nitrosamines in Soil

  19. Esthetic outcome for maxillary anterior single implants assessed by different dental specialists.

    Science.gov (United States)

    Al-Dosari, Abdullah; Al-Rowis, Ra'ed; Moslem, Feras; Alshehri, Fahad; Ballo, Ahmed M

    2016-10-01

    The aim of this study was to assess the esthetic outcome of maxillary anterior single implants by comparing the esthetic perception of dental professionals and patients. Twenty-three patients with single implants in the esthetic zone were enrolled in this study. Dentists of four different dental specialties (Three orthodontists, three oral surgeons, three prosthodontists, and three periodontists) evaluated the pink esthetic score (PES)/white esthetic score (WES) for 23 implant-supported single restorations. The satisfactions of the patients on the esthetic outcome of the treatment have been evaluated according to the visual analog scale (VAS). The mean total PES/WES was 12.26 ± 4.76. The mean PES was 6.45 ± 2.78 and mean WES was 5.80 ± 2.82. There was a statistically significant difference among the different specialties for WES ( P esthetic perception, thereby providing rationales for involving patients in the treatment plan to achieve higher levels of patient satisfaction.

  20. Teaching English or Producing Docility? Foucauldian Analysis of Pakistani State-Mandated English Textbooks

    Science.gov (United States)

    Channa, Liaquat Ali; Gilhooly, Daniel; Channa, Abdul Razaque; Manan, Syed Abdul

    2017-01-01

    The scholarship of language education, particularly with reference to learning and use of English, is marked by varieties of English. One may note two broad models: (1) ENL, ESL, and EFL; (2) EIL, ELF, and WEs. Although the scholarship is replete with debates, the debates seem to only construct and maintain that learning English and its use are…

  1. De novo FBXO11 mutations are associated with intellectual disability and behavioural anomalies.

    Science.gov (United States)

    Fritzen, Daniel; Kuechler, Alma; Grimmel, Mona; Becker, Jessica; Peters, Sophia; Sturm, Marc; Hundertmark, Hela; Schmidt, Axel; Kreiß, Martina; Strom, Tim M; Wieczorek, Dagmar; Haack, Tobias B; Beck-Wödl, Stefanie; Cremer, Kirsten; Engels, Hartmut

    2018-05-01

    Intellectual disability (ID) has an estimated prevalence of 1.5-2%. In most affected individuals, its genetic basis remains unclear. Whole exome sequencing (WES) studies have identified a multitude of novel causative gene defects and have shown that a large proportion of sporadic ID cases results from de novo mutations. Here, we present two unrelated individuals with similar clinical features and deleterious de novo variants in FBXO11 detected by WES. Individual 1, a 14-year-old boy, has mild ID as well as mild microcephaly, corrected cleft lip and alveolus, hyperkinetic disorder, mild brain atrophy and minor facial dysmorphism. WES detected a heterozygous de novo 1 bp insertion in the splice donor site of exon 3. Individual 2, a 3-year-old boy, showed ID and pre- and postnatal growth retardation, postnatal mild microcephaly, hyperkinetic and restless behaviour, as well as mild dysmorphism. WES detected a heterozygous de novo frameshift mutation. While ten individuals with ID and de novo variants in FBXO11 have been reported as part of larger studies, only one of the reports has some additional clinical data. Interestingly, the latter individual carries the identical mutation as our individual 2 and also displays ID, intrauterine growth retardation, microcephaly, behavioural anomalies, and dysmorphisms. Thus, we confirm deleterious de novo mutations in FBXO11 as a cause of ID and start the delineation of the associated clinical picture which may also comprise postnatal microcephaly or borderline small head size and behavioural anomalies.

  2. 75 FR 56578 - Renewal of the Advisory Committee on Apprenticeship (ACA), and an Open Meeting

    Science.gov (United States)

    2010-09-16

    ..., Training Project Manager, Corporate Training Development, United Parcel Service, Atlanta, Georgia. Mr. Wes... Training, United Association of Journeymen & Apprentices of the Plumbing & Pipe Fitting Industry of the U.S... America, Pomfret Center, Connecticut. Ms. Charissa Raynor, Executive Director, Service Employees...

  3. Antitussive arabinogalactan of Andrographis paniculata demonstrates synergistic effect with andrographolide.

    Science.gov (United States)

    Nosáľová, Gabriela; Majee, Sujay Kumar; Ghosh, Kanika; Raja, Washim; Chatterjee, Udipta Ranjan; Jureček, Ludovít; Ray, Bimalendu

    2014-08-01

    Traditional Indian medicines have been used in humans for thousands of years. While the link to a particular indication has been established in man, the active principle of the formulations often remains unknown. In this study, we aim to investigate the structural features and antitussive activity of fractions from Andrographis paniculata leaves. In vivo investigations of water extract (WE), and both ethanol-soluble (WES) and precipitated (WEP) fractions from WE on the citric-acid induced cough efforts and airways smooth muscle reactivity in guinea pigs were performed. Chemical, chromatographic and spectroscopic analysis revealed the existence of a highly branched pectic arabinogalactan (109kDa) in WEP and andrographolide in WES. WEP showed significant antitussive activity while the potencies of WE and WES are even higher. Neither WE nor WES significantly alter specific airway smooth muscle reactivity. Remarkably, the antitussive activity of arabinogalactan could be increased by synergistic action with andrographolide. Finally, traditional aqueous extraction method provides an arabinogalactan from A. paniculata, which stimulate biological response but without addiction. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Tjazhelovessõ Gollivuda v deistvii / Jevgeni Levik

    Index Scriptorium Estoniae

    Levik, Jevgeni

    2005-01-01

    Koguperefilm "Lemony Snicketi sari õnnetuid lugusid" ("Lemony Snicket's A Series of Unfortunate Events") : režissöör Brad Silberling : Ameerika Ühendriigid 2004 ja seikluslik komöödia "Steve Zissou ja veealune maailm" ("Life Aquatic with Steve Zissou") : režissöör Wes Anderson : Ameerika Ühendriigid 2004

  5. TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT

    NARCIS (Netherlands)

    Devalla, Harsha D.; Gélinas, Roselle; Aburawi, Elhadi H.; Beqqali, Abdelaziz; Goyette, Philippe; Freund, Christian; Chaix, Marie-A.; Tadros, Rafik; Jiang, Hui; Le Béchec, Antony; Monshouwer-Kloots, Jantine J.; Zwetsloot, Tom; Kosmidis, Georgios; Latour, Frédéric; Alikashani, Azadeh; Hoekstra, Maaike; Schlaepfer, Jurg; Mummery, Christine L.; Stevenson, Brian; Kutalik, Zoltan; de Vries, Antoine Af; Rivard, Léna; Wilde, Arthur Am; Talajic, Mario; Verkerk, Arie O.; Al-Gazali, Lihadh; Rioux, John D.; Bhuiyan, Zahurul A.; Passier, Robert

    2016-01-01

    Genetic causes of many familial arrhythmia syndromes remain elusive. In this study, whole-exome sequencing (WES) was carried out on patients from three different families that presented with life-threatening arrhythmias and high risk of sudden cardiac death (SCD). Two French Canadian probands

  6. The Top Three Valor Awards and the United States Marine Corps: A Study from World War I to Present Day Iraq and Afghanistan

    Science.gov (United States)

    2014-06-13

    the Medal of Honor.85 “The process by which the MOH is awarded has become flawed, and the DOD must strive to bring an end to an era of overprotection ...later in the literature review. 84Ibid., 37. 85Wes J. Deaver, “The Medal of Honor, An Era of Overprotection ,” Marine Corps Gazette 94, no. 9

  7. Molecular diagnostic experience of whole-exome sequencing in adult patients.

    Science.gov (United States)

    Posey, Jennifer E; Rosenfeld, Jill A; James, Regis A; Bainbridge, Matthew; Niu, Zhiyv; Wang, Xia; Dhar, Shweta; Wiszniewski, Wojciech; Akdemir, Zeynep H C; Gambin, Tomasz; Xia, Fan; Person, Richard E; Walkiewicz, Magdalena; Shaw, Chad A; Sutton, V Reid; Beaudet, Arthur L; Muzny, Donna; Eng, Christine M; Yang, Yaping; Gibbs, Richard A; Lupski, James R; Boerwinkle, Eric; Plon, Sharon E

    2016-07-01

    Whole-exome sequencing (WES) is increasingly used as a diagnostic tool in medicine, but prior reports focus on predominantly pediatric cohorts with neurologic or developmental disorders. We describe the diagnostic yield and characteristics of WES in adults. We performed a retrospective analysis of consecutive WES reports for adults from a diagnostic laboratory. Phenotype composition was determined using Human Phenotype Ontology terms. Molecular diagnoses were reported for 17.5% (85/486) of adults, which is lower than that for a primarily pediatric population (25.2%; P = 0.0003); the diagnostic rate was higher (23.9%) for those 18-30 years of age compared to patients older than 30 years (10.4%; P = 0.0001). Dual Mendelian diagnoses contributed to 7% of diagnoses, revealing blended phenotypes. Diagnoses were more frequent among individuals with abnormalities of the nervous system, skeletal system, head/neck, and growth. Diagnostic rate was independent of family history information, and de novo mutations contributed to 61.4% of autosomal dominant diagnoses. Early WES experience in adults demonstrates molecular diagnoses in a substantial proportion of patients, informing clinical management, recurrence risk, and recommendations for relatives. A positive family history was not predictive, consistent with molecular diagnoses often revealed by de novo events, informing the Mendelian basis of genetic disease in adults.Genet Med 18 7, 678-685.

  8. Analysis of wax esters by silver-ion high-performance liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Vrkoslav, Vladimír; Urbanová, Klára; Háková, Matina; Cvačka, Josef

    2013-08-09

    Wax esters (WEs), esters of long-chain fatty acids and long-chain alcohols, were analysed by Ag-HPLC/APCI-MS/MS. Two ChromSpher Lipids columns connected in series (a total length of 50cm) and hexane-2-propanol-acetonitrile mobile phases were used to achieve good separation of the molecular species. The chromatographic behaviour of WEs was studied under optimised conditions: retention increased with the number of double bonds and with the temperature (15-35°C); retention times were affected by the double-bond position, trans isomers eluted earlier than cis isomers, and the WEs were partially separated depending on the aliphatic-chain length. The WEs provided simple APCI spectra with [M+H](+) ions, the MS/MS spectra showed fragments, which allowed their identification. The method was applied for an analysis of the WE mixtures from jojoba oil and human hair and the results were compared with analogous data from an optimised RP-HPLC system. Copyright © 2013 Elsevier B.V. All rights reserved.

  9. The Danish organic movement from social movement to market mainstream and beyond …?

    DEFF Research Database (Denmark)

    Kjeldsen, Chris; Ingemann, Jan Holm

    2010-01-01

    The development of organic and with them various other forms of alternative food networks have been the subject of extensive research within the field of agro-food studies during the past 10–20 years. In that period, organic food has gained an increasing food market share and a wide number of Wes...

  10. Designing Efficient Self-Diagnosis Activities in the Physics Classroom

    Science.gov (United States)

    Safadi, Rafi'

    2017-01-01

    Self-diagnosis (SD) activities require students to self-diagnose their solutions to problems that they solved on their own. This involves identifying where they went wrong and then explaining the nature of their errors--why they went wrong--aided by some form of support. Worked examples (WEs) are often used to support students in SD activities. A…

  11. Rhabdosargus holubi Rhabdosargus globiceps

    African Journals Online (AJOL)

    Bioi. 17: 143-162. CARR, W.E.S. & ADAMS, C.A. 1973. Food habits of juvenile marine fishes occupying seagrass beds in the estuarine zone near. Crystal River, Florida. Trans. A mer. Fish. Soc. 3: 511- 540. CHARLES, R. 1975. Aspects of the biology of the mojarra. Eucinostomus gula (Quoy & Gaimard), in the Biscayne Bay,.

  12. Regional Planning, Local Visions : Participatory Futuring in West Africa

    OpenAIRE

    Peter Easton

    2000-01-01

    The note examines regional planning, and future participatory methods for economic development in West Africa, based on the work carried out by the Club du Sahel - a branch of the Organization for Economic Cooperation and Development (OECD) - responsible for coordinating northern donor agencies, in support of food security, and natural resource management in the desert-edge portions of Wes...

  13. Streptomyces roietensis sp. nov., an endophytic actinobacterium isolated from the surface-sterilized stem of jasmine rice, Oryza sativa KDML 105.

    Science.gov (United States)

    Kaewkla, Onuma; Franco, Christopher Milton Mathew

    2017-11-01

    An endophytic actinobacterium, strain WES2 T , was isolated from the stem of a jasmine rice plant collected from a paddy field in Thung Gura Rong Hai, Roi Et province, Thailand. As a result of a polyphasic study, this strain was identified as representing a novel member of the genus Streptomyces. This strain was a Gram-stain-positive, aerobic actinobacterium with well-developed substrate mycelia and forming chains of looped spores. The closest phylogenetic relations, which shared the highest 16S rRNA gene sequence similarity, were Streptomyces nogalater JCM 4799 T and Streptomyces lavenduligriseus NRRL-ISP 5487 T at 99.1 and 99.0 %, respectively. Chemotaxonomic data, including major fatty acids, cell wall components and major menaquinones, confirmed the affiliation of WES2 T to the genus Streptomyces. The data from the phylogenetic analysis, including physiological and biochemical studies and DNA-DNA hybridization, revealed the genotypic and phenotypic differentiation of WES2 T from the most closely related species with validly published names. The name proposed for the novel species is Streptomycesroietensis sp. nov. The type strain is WES2 T (=DSM 101729=NRRL B-65344).

  14. Performance Characteristics of Plane Wall Two Dimensional Diffusers

    Science.gov (United States)

    1953-02-01

    die Umsetzung von Wässergeschwindigkeit in Druck . Mitt. Forsch.-Arb. Geb. Ing.-Wes., Heft 76, 1909. k6 NACA TN 2888 12. Hochschild, Heinrich...Wi 0 2/ .75 ■ /5.2s A //.00 D 7.75 • 5. 3D & \\\\ /2 /e Z d, &&3 20 24 Figure 15.- Variation of pressure efficiency with divergence angle

  15. PER 2009(4)

    African Journals Online (AJOL)

    PER Electronic Law Review - Potchefstoomse Elektroniese Regsblad

    38 In Wes-Australië is die gekodifiseerde verweer van noodweer, soos vervat in die Criminal. Code, in 2008 op grond van ... 39 In Victoria word noodweer in die algemeen deur a 9AC en 9AE Crimes Act 1958 gereël, terwyl a 9AH spesifieke ...... uitg (Printing Things Potchefstroom 2005). Roth Briefing Paper No 3/07.

  16. Clinical Applicability of Whole-Exome Sequencing Exemplified by a Study in Young Adults with the Advanced Cryptogenic Cholestatic Liver Diseases

    Directory of Open Access Journals (Sweden)

    Maria Kulecka

    2017-01-01

    Full Text Available Background. The proper use of new medical tests in clinical practice requires the establishment of their value and range of diagnostic usefulness. While whole-exome sequencing (WES has already entered the medical practice, recognizing its diagnostic usefulness in multifactorial diseases has not yet been achieved. Aims. The objective of this study was to establish usability of WES in determining genetic background of chronic cholestatic liver disease (CLD in young patients. Methods. WES was performed on six young patients (between 17 and 22 years old with advanced fibrosis or cirrhosis due to CLD and their immediate families. Sequencing was performed on an Ion Proton sequencer. Results. On average, 19,673 variants were identified, of which from 7 to 14 variants of an individual were nonsynonymous, homozygous, recessively inherited, and considered in silico as pathogenic. Although monogenic cause of CLD has not been determined, several heterozygous rare variants and polymorphisms were uncovered in genes previously known to be associated with CLD, including ATP8B1, ABCB11, RXRA, and ABCC4, indicative of multifactorial genetic background. Conclusions. WES is a potentially useful diagnostic tool in determining genetic background of multifactorial diseases, but its main limitation results from the lack of opportunities for direct linkage between the uncovered genetic variants and molecular mechanisms of disease.

  17. Importance of comprehensive molecular profiling for clinical outcome in children with recurrent cancer

    DEFF Research Database (Denmark)

    Østrup, Olga; Nysom, Karsten; Scheie, David

    2018-01-01

    treatment. Results: Of the 48 patients, 33 had actionable findings. The most efficient method for the identification of actionable findings was WES (39%), followed by SNP array (37%). Of note, gene fusions were identified by RNAseq in 21% of the samples. Eleven findings led to clinical intervention, i...

  18. Whole-exome sequencing and an iPSC-derived cardiomyocyte model provides a powerful platform for gene discovery in left ventricular hypertrophy

    Directory of Open Access Journals (Sweden)

    Degui eZhi

    2012-05-01

    Full Text Available Rationale: Left ventricular hypertrophy (LVH is a heritable predictor of cardiovascular disease, particularly in blacks. Objective: Determine the feasibility of combining evidence from two distinct but complimentary experimental approaches to identify novel genetic predictors of increased LV mass . Methods: Whole exome sequencing (WES was conducted in 7 African American sibling trios ascertained on high average familial LV mass indexed to height (LVMHT. WES identified 31,426 missense or nonsense mutations (MS/NS which were examined for association with LVMHT using linear mixed models adjusted for age, sex, body weight, and family relationship. To functionally assess WES findings, human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM were stimulated to induce hypertrophy; mRNA sequencing was used to determine expression differences associated with hypertrophy onset. Results: After correction for multiple testing, 295 MS/NS variants in 265 genes were associated with LVMHT. We identified 44 of 265 WES genes differentially expressed (P<0.05 in hypertrophied cells. To further prioritize these 44 candidates, 7 supportive statistical and annotation-based criteria were used to evaluate the relevance of these genes. Five genes, HLA-B, HTT, MTSS1, SLC5A12, THBS1, were each supported by 3 criteria. THBS1 encodes an adhesive glycoprotein that promotes matrix preservation in pressure-overload LVH and harbors conserved and predicted damaging variants. Conclusions: Combining evidence from cutting-edge genetic and cellular experiments can enable identification of novel LVH risk loci.

  19. Early-Onset Severe Encephalopathy with Epilepsy: The BRAT1 Gene Should Be Added to the List of Causes

    NARCIS (Netherlands)

    van de Pol, L.A.; Wolf, N.I.; van Weissenbruch, M.M.; Stam, C.J.; Weiss, M.M.; Waisfisz, Q.; Kevelam, S.H.; Bugiani, M.; van de Kamp, J.M.; Knaap, M.

    2015-01-01

    A variety of pathologies can underlie early-onset severe encephalopathy with epilepsy. To aid the diagnostic process in such patients we present an overview of causes, including the rapidly expanding list of genes involved. When no explanation is found, whole-exome sequencing (WES) can be used in an

  20. Exome sequencing unravels unexpected differential diagnoses in individuals with the tentative diagnosis of Coffin-Siris and Nicolaides-Baraitser syndromes.

    Science.gov (United States)

    Bramswig, Nuria C; Lüdecke, Hermann-Josef; Alanay, Yasemin; Albrecht, Beate; Barthelmie, Alexander; Boduroglu, Koray; Braunholz, Diana; Caliebe, Almuth; Chrzanowska, Krystyna H; Czeschik, Johanna Christina; Endele, Sabine; Graf, Elisabeth; Guillén-Navarro, Encarna; Kiper, Pelin Özlem Simsek; López-González, Vanesa; Parenti, Ilaria; Pozojevic, Jelena; Utine, Gulen Eda; Wieland, Thomas; Kaiser, Frank J; Wollnik, Bernd; Strom, Tim M; Wieczorek, Dagmar

    2015-06-01

    Coffin-Siris syndrome (CSS) and Nicolaides-Baraitser syndrome (NCBRS) are rare intellectual disability/congenital malformation syndromes that represent distinct entities but show considerable clinical overlap. They are caused by mutations in genes encoding members of the BRG1- and BRM-associated factor (BAF) complex. However, there are a number of patients with the clinical diagnosis of CSS or NCBRS in whom the causative mutation has not been identified. In this study, we performed trio-based whole-exome sequencing (WES) in ten previously described but unsolved individuals with the tentative diagnosis of CSS or NCBRS and found causative mutations in nine out of ten individuals. Interestingly, our WES analysis disclosed overlapping differential diagnoses including Wiedemann-Steiner, Kabuki, and Adams-Oliver syndromes. In addition, most likely causative de novo mutations were identified in GRIN2A and SHANK3. Moreover, trio-based WES detected SMARCA2 and SMARCA4 deletions, which had not been annotated in a previous Haloplex target enrichment and next-generation sequencing of known CSS/NCBRS genes emphasizing the advantages of WES as a diagnostic tool. In summary, we discuss the phenotypic and diagnostic challenges in clinical genetics, establish important differential diagnoses, and emphasize the cardinal features and the broad clinical spectrum of BAF complex disorders and other disorders caused by mutations in epigenetic landscapers.