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Sample records for e50k disrupts rab8

  1. Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis

    Science.gov (United States)

    Sato, Takashi; Iwano, Tomohiko; Kunii, Masataka; Matsuda, Shinji; Mizuguchi, Rumiko; Jung, Yongwook; Hagiwara, Haruo; Yoshihara, Yoshihiro; Yuzaki, Michisuke; Harada, Reiko; Harada, Akihiro

    2014-01-01

    ABSTRACT The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms. Rab8a has a closely related isoform, Rab8b. To determine whether Rab8b can compensate for Rab8a, we generated Rab8b-knockout mice. Although the Rab8b-knockout mice did not display an overt phenotype, Rab8a and Rab8b double-knockout mice exhibited mislocalisation of apical markers and died earlier than Rab8a-knockout mice. The apical markers accumulated in three intracellular patterns in the double-knockout mice. However, the localisation of basolateral and/or dendritic markers of the double-knockout mice seemed normal. The morphology and the length of various primary and/or motile cilia, and the frequency of ciliated cells appeared to be identical in control and double-knockout mice. However, an additional knockdown of Rab10 in double-knockout cells greatly reduced the percentage of ciliated cells. Our results highlight the compensatory effect of Rab8a and Rab8b in apical transport, and the complexity of the apical transport process. In addition, neither Rab8a nor Rab8b are required for basolateral and/or dendritic transport. However, simultaneous loss of Rab8a and Rab8b has little effect on ciliogenesis, whereas additional loss of Rab10 greatly affects ciliogenesis. PMID:24213529

  2. LRRK2 mediated Rab8a phosphorylation promotes lipid storage.

    Science.gov (United States)

    Yu, Miao; Arshad, Muhammad; Wang, Wenmin; Zhao, Dongyu; Xu, Li; Zhou, Linkang

    2018-02-27

    Several mutations in leucine rich repeat kinase 2 (LRRK2) gene have been associated with pathogenesis of Parkinson's disease (PD), a neurodegenerative disorder marked by resting tremors, and rigidity, leading to Postural instability. It has been revealed that mutations that lead to an increase of kinase activity of LRRK2 protein are significantly associated with PD pathogenesis. Recent studies have shown that some Rab GTPases, especially Rab8, serve as substrates of LRRK2 and undergo phosphorylation in its switch II domain upon interaction. Current study was performed in order to find out the effects of the phosphorylation of Rab8 and its mutants on lipid metabolism and lipid droplets growth. The phosphorylation status of Rab8a was checked by phos-tag gel. Point mutant construct were generated to investigate the function of Rab8a. 3T3L1 cells were transfected with indicated plasmids and the lipid droplets were stained with Bodipy. Fluorescent microscopy experiments were performed to examine the sizes of lipid droplets. The interactions between Rab8a and Optineurin were determined by immunoprecipitation and western blot. Our assays demonstrated that Rab8a was phosphorylated by mutated LRRK2 that exhibits high kinase activity. Phosphorylation of Rab8a on amino acid residue T72 promoted the formation of large lipid droplets. T72D mutant of Rab8a had higher activity to promote the formation of large lipid droplets compared with wild type Rab8a, with increase in average diameter of lipid droplets from 2.10 μm to 2.46 μm. Moreover, phosphorylation of Rab8a weakened the interaction with its effector Optineurin. Y1699C mutated LRRK2 was able to phosphorylate Rab8a and phosphorylation of Rab8a on site 72 plays important role in the fusion and enlargement of lipid droplets. Taken together, our study suggests an indirect relationship between enhanced lipid storage capacity and PD pathogenesis.

  3. Expression profiling of microRNAs in optineurin (E50K) mutant transgenic mice.

    Science.gov (United States)

    Gao, Lin; Jiang, B O; Lei, Dawei; Zhou, Xinrong; Yuan, Huiping

    2016-02-01

    An E50K substitution in the transcription factor optineurin (OPTN) induces primary open-angle glaucoma (POAG). To explore the potential role of microRNAs (miRNAs) in E50K OPTN-induced POAG, miRNA expression profiling was performed on retinal samples from OPTN (E50K) transgenic and wild-type mice. The retinas were collected from 30 transgenic and 30 wild-type mice, and miRNA expression was evaluated using a genome-wide miRNA microarray. miRNAs that were differentially expressed in retinal samples from OPTN (E50K) transgenic mice were identified and validated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Additional gene ontology and signaling pathway analyses were performed using bioinformatics tools. A total of 48 miRNAs exhibited increased or decreased expression in the retinas from OPTN (E50K) transgenic mice when compared with the expression in the retinas from wild-type mice. A total of 5 miRNAs with increased expression in OPTN (E50K) transgenic mice could be grouped into one cluster as they belong to the miR-8 family and may act as regulators in the development of POAG in OPTN (E50K) transgenic mice. RT-qPCR results confirmed significantly increased expression of miR-141 in the retinas of OPTN (E50K) transgenic mice as compared to wild-type mice. In conclusion, these results show that certain miRNAs are differentially expressed in the retinas of OPTN (E50K) transgenic mice and may play roles in the pathogenesis of POAG induced by OPTN (E50K).

  4. RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6

    Directory of Open Access Journals (Sweden)

    Kubilay Demir

    2013-09-01

    Full Text Available Wnt/β-catenin signaling plays an important role in embryonic development and adult tissue homeostasis. When Wnt ligands bind to the receptor complex, LRP5/6 coreceptors are activated by phosphorylation and concomitantly endocytosed. In vertebrates, Wnt ligands induce caveolin-dependent endocytosis of LRP6 to relay signal downstream, whereas antagonists such as Dickkopf promote clathrin-dependent endocytosis, leading to inhibition. However, little is known about how LRP6 is directed to different internalization mechanisms, and how caveolin-dependent endocytosis is mediated. In an RNAi screen, we identified the Rab GTPase RAB8B as being required for Wnt/β-catenin signaling. RAB8B depletion reduces LRP6 activity, β-catenin accumulation, and induction of Wnt target genes, whereas RAB8B overexpression promotes LRP6 activity and internalization and rescues inhibition of caveolar endocytosis. In Xenopus laevis and Danio rerio, RAB8B morphants show lower Wnt activity during embryonic development. Our results implicate RAB8B as an essential evolutionary conserved component of Wnt/β-catenin signaling through regulation of LRP6 activity and endocytosis.

  5. The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium

    Science.gov (United States)

    Zilber, Yulia; Babayeva, Sima; Seo, Jung Hwa; Liu, Jia Jia; Mootin, Steven; Torban, Elena

    2013-01-01

    The planar cell polarity (PCP) pathway controls multiple cellular processes during vertebrate development. Recently the PCP pathway was implicated in ciliogenesis and in ciliary function. The primary cilium is an apically projecting solitary organelle that is generated via polarized intracellular trafficking. Because it acts as a signaling nexus, defects in ciliogenesis or cilial function cause multiple congenital anomalies in vertebrates. Loss of the PCP effector Fuzzy affects PCP signaling and formation of primary cilia; however, the mechanisms underlying these processes are largely unknown. Here we report that Fuzzy localizes to the basal body and ciliary axoneme and is essential for ciliogenesis by delivering Rab8 to the basal body and primary cilium. Fuzzy appears to control subcellular localization of the core PCP protein Dishevelled, recruiting it to Rab8-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP signaling and hyperactivation of the canonical WNT pathway. We propose a mechanism by which Fuzzy participates in ciliogenesis and affects both canonical WNT and PCP signaling. PMID:23303251

  6. Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

    DEFF Research Database (Denmark)

    Sakamori, Ryotaro; Das, Soumyashree; Yu, Shiyan

    2012-01-01

    The constant self renewal and differentiation of adult intestinal stem cells maintains a functional intestinal mucosa for a lifetime. However, the molecular mechanisms that regulate intestinal stem cell division and epithelial homeostasis are largely undefined. We report here that the small GTPases...... reminiscent of human microvillus inclusion disease (MVID), a devastating congenital intestinal disorder that results in severe nutrient deprivation. Further analysis revealed that Cdc42-deficient stem cells had cell division defects, reduced capacity for clonal expansion and differentiation into Paneth cells...... activity in the intestinal epithelium, where continued cell division takes place. Furthermore, mice haploinsufficient for both Cdc42 and Rab8a in the intestine demonstrated abnormal crypt morphogenesis and epithelial transporter physiology, further supporting their functional interaction. These data...

  7. Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth

    Directory of Open Access Journals (Sweden)

    Hotaka Kobayashi

    2014-08-01

    Full Text Available Small GTPase Rab35 is an important molecular switch for endocytic recycling that regulates various cellular processes, including cytokinesis, cell migration, and neurite outgrowth. We previously showed that active Rab35 promotes nerve growth factor (NGF-induced neurite outgrowth of PC12 cells by recruiting MICAL-L1, a multiple Rab-binding protein, to Arf6-positive recycling endosomes. However, the physiological significance of the multiple Rab-binding ability of MICAL-L1 during neurite outgrowth remained completely unknown. Here we report that Rab35 and MICAL-L1 promote the recruitment of Rab8, Rab13, and Rab36 to Arf6-positive recycling endosomes during neurite outgrowth. We found that Rab35 functions as a master Rab that determines the intracellular localization of MICAL-L1, which in turn functions as a scaffold for Rab8, Rab13, and Rab36. We further showed by functional ablation experiments that each of these downstream Rabs regulates neurite outgrowth in a non-redundant manner downstream of Rab35 and MICAL-L1, e.g. by showing that knockdown of Rab36 inhibited recruitment of Rab36-specific effector JIP4 to Arf6-positive recycling endosomes, and caused inhibition of neurite outgrowth without affecting accumulation of Rab8 and Rab13 in the same Arf6-positive area. Our findings suggest the existence of a novel mechanism that recruits multiple Rab proteins at the Arf6-positive compartment by MICAL-L1.

  8. Disruption?

    DEFF Research Database (Denmark)

    2016-01-01

    This is a short video on the theme disruption and entrepreneurship. It takes the form of an interview with John Murray......This is a short video on the theme disruption and entrepreneurship. It takes the form of an interview with John Murray...

  9. Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors.

    Science.gov (United States)

    Ojeda Naharros, Irene; Gesemann, Matthias; Mateos, José M; Barmettler, Gery; Forbes, Austin; Ziegler, Urs; Neuhauss, Stephan C F; Bachmann-Gagescu, Ruxandra

    2017-12-01

    Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous organelles involved in transduction of environmental signals such as light sensation in photoreceptors. Concentration of signal detection proteins such as opsins in the ciliary membrane is achieved by RabGTPase-regulated polarized vesicle trafficking and by a selective barrier at the ciliary base, the transition zone (TZ). Dysfunction of the TZ protein CC2D2A causes Joubert/Meckel syndromes in humans and loss of ciliary protein localization in animal models, including opsins in retinal photoreceptors. The link between the TZ and upstream vesicle trafficking has been little explored to date. Moreover, the role of the small GTPase Rab8 in opsin-carrier vesicle (OCV) trafficking has been recently questioned in a mouse model. Using correlative light and electron microscopy and live imaging in zebrafish photoreceptors, we provide the first live characterization of Rab8-mediated trafficking in photoreceptors in vivo. Our results support a possibly redundant role for both Rab8a/b paralogs in OCV trafficking, based on co-localization of Rab8 and opsins in vesicular structures, and joint movement of Rab8-tagged particles with opsin. We further investigate the role of the TZ protein Cc2d2a in Rab8-mediated trafficking using cc2d2a zebrafish mutants and identify a requirement for Cc2d2a in the latest step of OCV trafficking, namely vesicle fusion. Progressive accumulation of opsin-containing vesicles in the apical portion of photoreceptors lacking Cc2d2a is caused by disorganization of the vesicle fusion machinery at the periciliary membrane with mislocalization and loss of the t-SNAREs SNAP25 and Syntaxin3 and of the exocyst component Exoc4. We further observe secondary defects on upstream Rab8-trafficking with cytoplasmic accumulation of Rab8. Taken together, our results support participation of Rab8 in OCV trafficking and identify a novel role for the TZ protein Cc2d2a in fusion of incoming

  10. The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking.

    Directory of Open Access Journals (Sweden)

    Ruxandra Bachmann-Gagescu

    2015-10-01

    Full Text Available Ciliopathies are a group of human disorders caused by dysfunction of primary cilia, ubiquitous microtubule-based organelles involved in transduction of extra-cellular signals to the cell. This function requires the concentration of receptors and channels in the ciliary membrane, which is achieved by complex trafficking mechanisms, in part controlled by the small GTPase RAB8, and by sorting at the transition zone located at the entrance of the ciliary compartment. Mutations in the transition zone gene CC2D2A cause the related Joubert and Meckel syndromes, two typical ciliopathies characterized by central nervous system malformations, and result in loss of ciliary localization of multiple proteins in various models. The precise mechanisms by which CC2D2A and other transition zone proteins control protein entrance into the cilium and how they are linked to vesicular trafficking of incoming cargo remain largely unknown. In this work, we identify the centrosomal protein NINL as a physical interaction partner of CC2D2A. NINL partially co-localizes with CC2D2A at the base of cilia and ninl knockdown in zebrafish leads to photoreceptor outer segment loss, mislocalization of opsins and vesicle accumulation, similar to cc2d2a-/- phenotypes. Moreover, partial ninl knockdown in cc2d2a-/- embryos enhances the retinal phenotype of the mutants, indicating a genetic interaction in vivo, for which an illustration is found in patients from a Joubert Syndrome cohort. Similar to zebrafish cc2d2a mutants, ninl morphants display altered Rab8a localization. Further exploration of the NINL-associated interactome identifies MICAL3, a protein known to interact with Rab8 and to play an important role in vesicle docking and fusion. Together, these data support a model where CC2D2A associates with NINL to provide a docking point for cilia-directed cargo vesicles, suggesting a mechanism by which transition zone proteins can control the protein content of the ciliary

  11. Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Olivier Devergne

    2017-02-01

    Full Text Available The basement membrane (BM, a sheet of extracellular matrix lining the basal side of epithelia, is essential for epithelial cell function and integrity, yet the mechanisms that control the basal restriction of BM proteins are poorly understood. In epithelial cells, a specialized pathway is dedicated to restrict the deposition of BM proteins basally. Here, we report the identification of a factor in this pathway, a homolog of the mammalian guanine nucleotide exchange factor (GEF Mss4, which we have named Stratum. The loss of Stratum leads to the missecretion of BM proteins at the apical side of the cells, forming aberrant layers in close contact with the plasma membrane. We found that Rab8GTPase acts downstream of Stratum in this process. Altogether, our results uncover the importance of this GEF/Rab complex in specifically coordinating the basal restriction of BM proteins, a critical process for the establishment and maintenance of epithelial cell polarity.

  12. Investigating Disruption

    DEFF Research Database (Denmark)

    Lundgaard, Stine Schmieg; Rosenstand, Claus Andreas Foss

    This book shares knowledge collected from 2015 and onward within the Consortium for Digital Disruption anchored at Aalborg University (www.dd.aau.dk). Evidenced by this publication, the field of disruptive innovation research has gone through several stages of operationalizing the theory. In recent...... years, researchers are increasingly looking back towards the origins of the theory in attempts to cure it from its most obvious flaws. This is especially true for the use of the theory in making predictions about future disruptions. In order to continue to develop a valuable theory of disruption, we...... find it useful to first review what the theory of disruptive innovation initially was, how it has developed, and where we are now. A cross section of disruptive innovation literature has been reviewed in order to form a general foundation from which we might better understand the changing world...

  13. Disruption model

    International Nuclear Information System (INIS)

    Murray, J.G.; Bronner, G.

    1982-07-01

    Calculations of disruption time and energy dissipation have been obtained by simulating the plasma as an electrical conducting loop that varies in resistivity, current density, major radius. The calculations provide results which are in good agreement with experimental observations. It is believed that this approach allows engineering designs for disruptions to be completed in large tokamaks such as INTOR or FED

  14. Digital Disruption

    DEFF Research Database (Denmark)

    Rosenstand, Claus Andreas Foss

    Disruption var frem til slutningen af 2016 i Danmark et ord, som kun få kendte og endnu færre havde en holdning til. Nu er der imidlertid sat fokus på begrebet fra allerhøjeste nationale sted, idet regeringen har taget initiativ til nedsættelse af det, Statsminister Lars Løkke Rasmussen indtil...... videre kalder et ”disruption-råd”. Faktisk er rådet skrevet ind i 2016 regeringsgrundlaget for VLK-regeringen. Disruption af organisationer er ikke et nyt fænomen; men hastigheden, hvormed det sker, er stadig accelererende. Årsagen er den globale mega-trend: Digitalisering. Og derfor er specielt digital...... disruption en sag for os alle. Derfor er det også for vigtigt et emne til, at det udelukkende behandles i elitære videnskabelige, industrielle og politiske kredse. Der er behov for en bredere samfundsdebat; og bogen er et forskningsbaseret bidrag ind i denne debat. For a kvalificere debatten om disruption i...

  15. Politisk disruption

    DEFF Research Database (Denmark)

    Tække, Jesper

    2018-01-01

    Dette blogindlæg giver en kort analyse af hvordan de sociale medier ved at give en ny tid har åbnet for den disruption af de politiske processer som især Trump stå som et eksempel på.......Dette blogindlæg giver en kort analyse af hvordan de sociale medier ved at give en ny tid har åbnet for den disruption af de politiske processer som især Trump stå som et eksempel på....

  16. Disrupting Business

    DEFF Research Database (Denmark)

    Cox, Geoff; Bazzichelli, Tatiana

    Disruptive Business explores some of the interconnections between art, activism and the business concept of disruptive innovation. With a backdrop of the crisis of financial capitalism, austerity cuts in the cultural sphere, the idea is to focus on potential art strategies in relation to a broken...... economy. In a perverse way, we ask whether this presents new opportunities for cultural producers to achieve more autonomy over their production process. If it is indeed possible, or desirable, what alternative business models emerge? The book is concerned broadly with business as material for reinvention...

  17. Sustainable Disruptions

    DEFF Research Database (Denmark)

    Friis, Silje Alberthe Kamille; Kjær, Lykke Bloch

    2016-01-01

    Since 2012 the Sustainable Disruptions (SD) project at the Laboratory for Sustainability at Design School Kolding (DK) has developed and tested a set of design thinking tools, specifically targeting the barriers to economically, socially, and environmentally sustainable business development...... invested in the issue of sustainable business development, in particular the leaders and employees of SMEs, but also to design education seeking new ways to consciously handle and teach the complexity inherent in sustainable transformation. Findings indicate that the SD design thinking approach contributes....... The tools have been applied in practice in collaboration with 11 small and medium sized companies (SMEs). The study investigates these approaches to further understand how design thinking can contribute to sustainable transition in a business context. The study and the findings are relevant to organizations...

  18. Disrupted Disclosure

    DEFF Research Database (Denmark)

    Krause Hansen, Hans; Uldam, Julie

    , and onongoing research in the extractive industries and social movements, this work-in-progress sets outto examine (a) why and how transparency has been constructed and mobilized in recentinternational attempts to regulate the extractive industries, specifically oil and gas companies; (b)how companies’ normal...... appearances become challenged through disruptive disclosures in mediaenvironments characterized by multiple levels of visibility, with companies both observing andbeing observed by civil society groups that criticize them; (c) why and how the mobilization aroundtransparency and ensuing practices......While projects of governance by transparency have become widespread over the past decades, theyare usually investigated and theorized in isolation from the wider field of visibility and surveillancein which they are embedded. Building on theories of governance, visibility and surveillance...

  19. Endocrine Disrupting Chemicals (EDCs)

    Science.gov (United States)

    ... Center Pacientes y Cuidadores Hormones and Health The Endocrine System Hormones Endocrine Disrupting Chemicals (EDCs) Steroid and Hormone ... Hormones and Health › Endocrine Disrupting Chemicals (EDCs) The Endocrine System Hormones Endocrine Disrupting Chemicals (EDCs) EDCs Myth vs. ...

  20. Search and Disrupt

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders

    Extant research on external knowledge search and open innovation assumes that collaborators are aligned in their strategic interests towards solving innovation problems. However, disruptive innovation is known to threaten the competitive advantage of incumbent firms, thereby creating a potential...

  1. Search and Disrupt

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders

    This paper analyzes how external search is affected by strategic interest alignment among knowledge sources. I focus on misalignment arising from the heterogeneous effects of disruptive technologies by analyzing the influence of incumbents on 2,855 non-incumbents? external knowledge search efforts....... The efforts most likely to solve innovation problems obtained funding from the European Commission?s 7th Framework Program (2007-2013). The results show that involving incumbents improves search in complementary technologies, while demoting it when strategic interests are misaligned in disruptive technologies....... However, incumbent sources engaged in capability reconfiguration to accommodate disruption improve search efforts in disruptive technologies. The paper concludes that the value of external sources is contingent on more than their knowledge. Specifically, interdependence of sources in search gives rise...

  2. Disruption Rose Tinted II

    OpenAIRE

    Livingstone, Andrew

    2009-01-01

    'Disruption - Rose Tinted II' continues to engage narratives of historical English china as previously explored in the work 'Rose Tinted'. This work engages the sleepy rural idyll which is overlaid with visual contemporary social commentary.

  3. Digital disruption ?syndromes.

    Science.gov (United States)

    Sullivan, Clair; Staib, Andrew

    2017-05-18

    The digital transformation of hospitals in Australia is occurring rapidly in order to facilitate innovation and improve efficiency. Rapid transformation can cause temporary disruption of hospital workflows and staff as processes are adapted to the new digital workflows. The aim of this paper is to outline various types of digital disruption and some strategies for effective management. A large tertiary university hospital recently underwent a rapid, successful roll-out of an integrated electronic medical record (EMR). We observed this transformation and propose several digital disruption "syndromes" to assist with understanding and management during digital transformation: digital deceleration, digital transparency, digital hypervigilance, data discordance, digital churn and post-digital 'depression'. These 'syndromes' are defined and discussed in detail. Successful management of this temporary digital disruption is important to ensure a successful transition to a digital platform. What is known about this topic? Digital disruption is defined as the changes facilitated by digital technologies that occur at a pace and magnitude that disrupt established ways of value creation, social interactions, doing business and more generally our thinking. Increasing numbers of Australian hospitals are implementing digital solutions to replace traditional paper-based systems for patient care in order to create opportunities for improved care and efficiencies. Such large scale change has the potential to create transient disruption to workflows and staff. Managing this temporary disruption effectively is an important factor in the successful implementation of an EMR. What does this paper add? A large tertiary university hospital recently underwent a successful rapid roll-out of an integrated electronic medical record (EMR) to become Australia's largest digital hospital over a 3-week period. We observed and assisted with the management of several cultural, behavioural and

  4. Endocrine disrupting compounds

    DEFF Research Database (Denmark)

    Bøgh, I B; Christensen, P; Dantzer, V

    2001-01-01

    processes, and exposure during critical periods of prenatal development might affect reproductive performance over several generations. Alkylphenols and their metabolites are lipophilic substances exerting apparent estrogenic action in in vitro and in vivo testing systems. With the widespread industrial use...... or embryo models for the evaluation of possible consequences of human exposure to endocrine disrupting compounds is discussed. Furthermore, possible consequences of exposure to endocrine disrupting compounds for the embryo transfer industry are addressed....

  5. Disruptive Mood Dysregulation Disorder (DMDD)

    Science.gov (United States)

    ... for Families Guide Facts for Families - Vietnamese Disruptive Mood Dysregulation Disorder (DMDD) No. 110; Updated May 2013 Disruptive Mood Dysregulation Disorder (DMDD) is a relatively new diagnosis ...

  6. Disruption prediction at JET

    International Nuclear Information System (INIS)

    Milani, F.

    1998-12-01

    The sudden loss of the plasma magnetic confinement, known as disruption, is one of the major issue in a nuclear fusion machine as JET (Joint European Torus). Disruptions pose very serious problems to the safety of the machine. The energy stored in the plasma is released to the machine structure in few milliseconds resulting in forces that at JET reach several Mega Newtons. The problem is even more severe in the nuclear fusion power station where the forces are in the order of one hundred Mega Newtons. The events that occur during a disruption are still not well understood even if some mechanisms that can lead to a disruption have been identified and can be used to predict them. Unfortunately it is always a combination of these events that generates a disruption and therefore it is not possible to use simple algorithms to predict it. This thesis analyses the possibility of using neural network algorithms to predict plasma disruptions in real time. This involves the determination of plasma parameters every few milliseconds. A plasma boundary reconstruction algorithm, XLOC, has been developed in collaboration with Dr. D. O'Brien and Dr. J. Ellis capable of determining the plasma wall/distance every 2 milliseconds. The XLOC output has been used to develop a multilayer perceptron network to determine plasma parameters as l i and q ψ with which a machine operational space has been experimentally defined. If the limits of this operational space are breached the disruption probability increases considerably. Another approach for prediction disruptions is to use neural network classification methods to define the JET operational space. Two methods have been studied. The first method uses a multilayer perceptron network with softmax activation function for the output layer. This method can be used for classifying the input patterns in various classes. In this case the plasma input patterns have been divided between disrupting and safe patterns, giving the possibility of

  7. Emerging and Disruptive Technologies.

    Science.gov (United States)

    Kricka, Larry J

    2016-08-01

    Several emerging or disruptive technologies can be identified that might, at some point in the future, displace established laboratory medicine technologies and practices. These include increased automation in the form of robots, 3-D printing, technology convergence (e.g., plug-in glucose meters for smart phones), new point-of-care technologies (e.g., contact lenses with sensors, digital and wireless enabled pregnancy tests) and testing locations (e.g., Retail Health Clinics, new at-home testing formats), new types of specimens (e.g., cell free DNA), big biology/data (e.g., million genome projects), and new regulations (e.g., for laboratory developed tests). In addition, there are many emerging technologies (e.g., planar arrays, mass spectrometry) that might find even broader application in the future and therefore also disrupt current practice. One interesting source of disruptive technology may prove to be the Qualcomm Tricorder XPrize, currently in its final stages.

  8. Interruptions disrupt reading comprehension.

    Science.gov (United States)

    Foroughi, Cyrus K; Werner, Nicole E; Barragán, Daniela; Boehm-Davis, Deborah A

    2015-06-01

    Previous research suggests that being interrupted while reading a text does not disrupt the later recognition or recall of information from that text. This research is used as support for Ericsson and Kintsch's (1995) long-term working memory (LT-WM) theory, which posits that disruptions while reading (e.g., interruptions) do not impair subsequent text comprehension. However, to fully comprehend a text, individuals may need to do more than recognize or recall information that has been presented in the text at a later time. Reading comprehension often requires individuals to connect and synthesize information across a text (e.g., successfully identifying complex topics such as themes and tones) and not just make a familiarity-based decision (i.e., recognition). The goal for this study was to determine whether interruptions while reading disrupt reading comprehension when the questions assessing comprehension require participants to connect and synthesize information across the passage. In Experiment 1, interruptions disrupted reading comprehension. In Experiment 2, interruptions disrupted reading comprehension but not recognition of information from the text. In Experiment 3, the addition of a 15-s time-out prior to the interruption successfully removed these negative effects. These data suggest that the time it takes to process the information needed to successfully comprehend text when reading is greater than that required for recognition. Any interference (e.g., an interruption) that occurs during the comprehension process may disrupt reading comprehension. This evidence supports the need for transient activation of information in working memory for successful text comprehension and does not support LT-WM theory. (c) 2015 APA, all rights reserved).

  9. Managing Supply Chain Disruptions

    Science.gov (United States)

    2008-08-09

    additional resources such as increased levels of inventory to restore operations following a disruption (Stonebraker & Afifi , 2004; Zsidisin et al...Other Disciplines to Logistics. International Journal of Physical Distribution & Logistics Management, 27(9/10), pp 515. Stonebraker, P. W. & Afifi

  10. Sustainable Disruption Management

    DEFF Research Database (Denmark)

    Vaaben, Bo Valdemar

    when managing recovery from disruptions. The underlying work of this thesis is carried out as an industrial PhD project in co-operation with the company Jeppesen, which have the airline industry as its primary area of business and the maritime industry as its secondary area. For this reason the thesis...

  11. Statistical analysis of JET disruptions

    International Nuclear Information System (INIS)

    Tanga, A.; Johnson, M.F.

    1991-07-01

    In the operation of JET and of any tokamak many discharges are terminated by a major disruption. The disruptive termination of a discharge is usually an unwanted event which may cause damage to the structure of the vessel. In a reactor disruptions are potentially a very serious problem, hence the importance of studying them and devising methods to avoid disruptions. Statistical information has been collected about the disruptions which have occurred at JET over a long span of operations. The analysis is focused on the operational aspects of the disruptions rather than on the underlining physics. (Author)

  12. [Xenoestrogens: endocrine disrupting compounds].

    Science.gov (United States)

    Wozniak, Milena; Murias, Marek

    2008-11-01

    In recent years much attention has been paid to the issues of chemicals that disrupt the normal function of endocrine system, namely xenoestrogens. These chemicals can mimic the activity of endogenous estrogens, antagonize their interaction with estrogen receptors or disrupt the synthesis, metabolism and functions of endogenous female hormones. Due to the fact that they act thanks to many different mechanisms, it is very difficult to estimate their estrogenic activity by means of a simple tests. The important issue remains the fact that xenoestrogens may have a positive or negative influence on the function of the endocrine system. It seems to be very important that there are many sources of xenoestrogens, that is not only vegetables and fruit (phytoestrogens), but also metals (Co, Cu, Ni, Cr, Pb), dental appliances (alkilphenols), food containers or blood containers (PVC--polyvinyl chloride, DEHP--di-(2-ethylhexyl) phthalate), cosmetics (parabens) and pesticides (DDT--dichlor-diphenyl-trichlorethylane, endosulfane).

  13. Disrupted Refugee Family Life

    DEFF Research Database (Denmark)

    Shapiro, Ditte Krogh

    2017-01-01

    Fleeing civil war involves managing life threatening events and multiple disruptions of everyday life. The theoretical potentials of analysing the recreation of everyday family life among Syrian refugees in Denmark is explored based on conceptualizations that emphasize the collective agency...... war and struggle to recreate an everyday life in exile is to contribute with contextualization and expansion of mainstream understandings of family life, suffering, and resilience in refugee family trajectories in multiple contexts....

  14. Wound Disruption Following Colorectal Operations.

    Science.gov (United States)

    Moghadamyeghaneh, Zhobin; Hanna, Mark H; Carmichael, Joseph C; Mills, Steven; Pigazzi, Alessio; Nguyen, Ninh T; Stamos, Michael J

    2015-12-01

    Postoperative wound disruption is associated with high morbidity and mortality. We sought to identify the risk factors and outcomes of wound disruption following colorectal resection. The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database was used to examine the clinical data of patients who underwent colorectal resection from 2005 to 2013. Multivariate regression analysis was performed to identify risk factors of wound disruption. We sampled a total of 164,297 patients who underwent colorectal resection. Of these, 2073 (1.3 %) had wound disruption. Patients with wound disruption had significantly higher mortality (5.1 vs. 1.9 %, AOR: 1.46, P = 0.01). The highest risk of wound disruption was seen in patients with wound infection (4.8 vs. 0.9 %, AOR: 4.11, P disruption such as chronic steroid use (AOR: 1.71, P disruption compared to open surgery (AOR: 0.61, P disruption occurs in 1.3 % of colorectal resections, and it correlates with mortality of patients. Wound infection is the strongest predictor of wound disruption. Chronic steroid use, obesity, severe COPD, prolonged operation, non-elective admission, and serum albumin level are strongly associated with wound disruption. Utilization of the laparoscopic approach may decrease the risk of wound disruption when possible.

  15. Disruption - Access cards service

    CERN Multimedia

    2014-01-01

    We would like to inform you that between 10 November and 15 December 2014, the access cards service in Building 55 will be disrupted, as the GS Department has decided to improve the facilities for users of this building. During the work, you will find the registration, biometric registration and dosimeter exchange services on the second floor of Building 55 and the vehicle sticker service on the ground floor along with the access cards service. We thank you for your understanding and apologise for any inconvenience caused.

  16. Relativistic tidal disruption events

    Directory of Open Access Journals (Sweden)

    Levan A.

    2012-12-01

    Full Text Available In March 2011 Swift detected an extremely luminous and long-lived outburst from the nucleus of an otherwise quiescent, low luminosity (LMC-like galaxy. Named Swift J1644+57, its combination of high-energy luminosity (1048 ergs s−1 at peak, rapid X-ray variability (factors of >100 on timescales of 100 seconds and luminous, rising radio emission suggested that we were witnessing the birth of a moderately relativistic jet (Γ ∼ 2 − 5, created when a star is tidally disrupted by the supermassive black hole in the centre of the galaxy. A second event, Swift J2058+0516, detected two months later, with broadly similar properties lends further weight to this interpretation. Taken together this suggests that a fraction of tidal disruption events do indeed create relativistic outflows, demonstrates their detectability, and also implies that low mass galaxies can host massive black holes. Here, I briefly outline the observational properties of these relativistic tidal flares observed last year, and their evolution over the first year since their discovery.

  17. Cell disruption for microalgae biorefineries.

    Science.gov (United States)

    Günerken, E; D'Hondt, E; Eppink, M H M; Garcia-Gonzalez, L; Elst, K; Wijffels, R H

    2015-01-01

    Microalgae are a potential source for various valuable chemicals for commercial applications ranging from nutraceuticals to fuels. Objective in a biorefinery is to utilize biomass ingredients efficiently similarly to petroleum refineries in which oil is fractionated in fuels and a variety of products with higher value. Downstream processes in microalgae biorefineries consist of different steps whereof cell disruption is the most crucial part. To maintain the functionality of algae biochemicals during cell disruption while obtaining high disruption yields is an important challenge. Despite this need, studies on mild disruption of microalgae cells are limited. This review article focuses on the evaluation of conventional and emerging cell disruption technologies, and a comparison thereof with respect to their potential for the future microalgae biorefineries. The discussed techniques are bead milling, high pressure homogenization, high speed homogenization, ultrasonication, microwave treatment, pulsed electric field treatment, non-mechanical cell disruption and some emerging technologies. Copyright © 2015 Elsevier Inc. All rights reserved.

  18. Endocrine disrupting chemicals

    DEFF Research Database (Denmark)

    Mandrup, Karen

    BACKGROUND: Endocrine disrupting chemicals (EDCs) may contribute to reproductive changes in boys in the Western world, however, less is known about influence of EDCs in women. The incidence of precocious breast development is increasing in USA and Europe and mammary gland development has been...... gland development before puberty in whole mounted mammary glands and in adults in histological sections of the mammary glands. Moreover, female offspring were evaluated for external genital malformations. The EDCs studied for mammary gland effects were the estrogenic compounds ethinyl estradiol...... were sensitive to EDCs. EDCs with estrogenic mode of action appeared to increase mammary outgrowth in prepubertal female rats and a potent model compound, ethinyl estradiol, increased the density in females and males and the number of terminal end buds in male rats. Histological examination showed...

  19. Overview of core disruptive accidents

    International Nuclear Information System (INIS)

    Marchaterre, J.F.

    1977-01-01

    An overview of the analysis of core-disruptive accidents is given. These analyses are for the purpose of understanding and predicting fast reactor behavior in severe low probability accident conditions, to establish the consequences of such conditions and to provide a basis for evaluating consequence limiting design features. The methods are used to analyze core-disruptive accidents from initiating event to complete core disruption, the effects of the accident on reactor structures and the resulting radiological consequences are described

  20. AIDS and economic disruption.

    Science.gov (United States)

    Johnson, G S

    1996-10-01

    Child and adult mortality increases in Cameroon due to AIDS will cause life expectancy to fall by as many as 8 years, from just over 50 to just over 40 years. The social consequences of AIDS include grieving, stigmatizing, and the large-scale disruption of family and community structures. Widows and widowers due to AIDS mortality are affected differently from each other, with the widows of men who have died from AIDS facing potential sociocultural and economic hardship. The economic consequences of AIDS in Bamenda and elsewhere in Cameroon will occur mainly through the epidemic's impact upon the size and quality of the labor force. By killing a significant number of male and female workers aged 15-60 years, AIDS will reduce the size and growth rate of the labor force. Despite, rapid population growth, labor is a relatively scarce factor of agricultural production in Cameroon. The spread of HIV in rural areas, combined with the intensity and scarcity of agricultural labor, suggests that AIDS will have an impact upon production and per capita incomes, and increase the already high rates of hunger and absolute poverty. In the context of HIV/AIDS, young people must be empowered to make informed decisions about sex. Adolescents are most at risk because they tend to experiment more than married couples and have many sex partners. Sexual activity begins as early as age 8 years and penetrative sex at age 13 or earlier. The author considers the factors which encourage adolescents to engage in sexual activities.

  1. Disrupting Ethnography through Rhizoanalysis

    Directory of Open Access Journals (Sweden)

    Diana Masny

    2014-10-01

    Full Text Available This article interrogates principles of ethnography in education proposed by Mills and Morton: raw tellings, analytic pattern, vignette and empathy. This article adopts a position that is uncomfortable, unconventional and interesting. It involves a deterritorialization/ rupture of ethnography in education in order to reterritorialize a different concept: rhizoanalysis, a way to position theory and data that is multilayered, complex and messy. Rhizoanalysis, the main focus of this article is not a method. It is an approach to research conditioned by a reality in which Deleuze and Guattari disrupt representation, interpretation and subjectivity. In this article, Multiple Literacies Theory, a theoretical and practical framework, becomes a lens to examine a rhizomatic study of a Korean family recently arrived to Australia and attending English as a second language classes. Observations and interviews recorded the daily lives of the family. The vignettes were selected by reading data intensively and immanently through a process of palpation, an innovative approach to educational research. Rhizoanalysis proposes to abandon the given and invent different ways of thinking about and doing research and what might happen when reading data differently, intensively and immanently, through Multiple Literacies Theory. Rhizoanalysis, a game-changer in the way research can be conducted, affords a different lens to tackle issues in education through research.

  2. Thigmotaxis Mediates Trail Odour Disruption.

    Science.gov (United States)

    Stringer, Lloyd D; Corn, Joshua E; Sik Roh, Hyun; Jiménez-Pérez, Alfredo; Manning, Lee-Anne M; Harper, Aimee R; Suckling, David M

    2017-05-10

    Disruption of foraging using oversupply of ant trail pheromones is a novel pest management application under investigation. It presents an opportunity to investigate the interaction of sensory modalities by removal of one of the modes. Superficially similar to sex pheromone-based mating disruption in moths, ant trail pheromone disruption lacks an equivalent mechanistic understanding of how the ants respond to an oversupply of their trail pheromone. Since significant compromise of one sensory modality essential for trail following (chemotaxis) has been demonstrated, we hypothesised that other sensory modalities such as thigmotaxis could act to reduce the impact on olfactory disruption of foraging behaviour. To test this, we provided a physical stimulus of thread to aid trailing by Argentine ants otherwise under disruptive pheromone concentrations. Trail following success was higher using a physical cue. While trail integrity reduced under continuous over-supply of trail pheromone delivered directly on the thread, provision of a physical cue in the form of thread slightly improved trail following and mediated trail disruption from high concentrations upwind. Our results indicate that ants are able to use physical structures to reduce but not eliminate the effects of trail pheromone disruption.

  3. Sleep disruption in chronic rhinosinusitis.

    Science.gov (United States)

    Mahdavinia, Mahboobeh; Schleimer, Robert P; Keshavarzian, Ali

    2017-05-01

    Chronic rhinosinusitis (CRS) is a common disease of the upper airways and paranasal sinuses with a marked decline in quality of life (QOL). CRS patients suffer from sleep disruption at a significantly higher proportion (60 to 75%) than in the general population (8-18 %). Sleep disruption in CRS causes decreased QOL and is linked to poor functional outcomes such as impaired cognitive function and depression. Areas covered: A systematic PubMed/Medline search was done to assess the results of studies that have investigated sleep and sleep disturbances in CRS. Expert commentary: These studies reported sleep disruption in most CRS patients. The main risk factors for sleep disruption in CRS include allergic rhinitis, smoking, and high SNOT-22 total scores. The literature is inconsistent with regard to the prevalence of sleep-related disordered breathing (e.g. obstructive sleep apnea) in CRS patients. Although nasal obstruction is linked to sleep disruption, the extent of sleep disruption in CRS seems to expand beyond that expected from physical blockage of the upper airways alone. Despite the high prevalence of sleep disruption in CRS, and its detrimental effects on QOL, the literature contains a paucity of studies that have investigated the mechanisms underlying this major problem in CRS.

  4. Ultrasonic disruption of algae cells

    Science.gov (United States)

    King, P. M.; Nowotarski, K.; Joyce, E. M.; Mason, T. J.

    2012-05-01

    During last decade there has been increasing interest in the production of sustainable fuels from microalgae (R.H. Wijffels and M.J. Barbosa, 2010; Singh et al 2011; D.H. Lee 2011). The aim of this project was to determine if algal cells can be ultrasonically disrupted to release lipids for biofuel production. Ultrasonic disruption of two unicellular algal species: Dunnaliella salina and Nannochloropsis oculata was investigated using a 20 kHz probe. Haemocytometer, optical density, UV-Vis, fluoro-spectrophotometer and confocal microscopy results demonstrated complete cell destruction of Dunaliella salina within 16 minutes of sonication. Results obtained for Nannochloropsis oculata differed in that ultrasound dispersed clumped cells with little or no cell disruption, as observed by haemocytometer and confocal microscopy analysis. However, UV-Visible and fluoro-spectrophotometer analysis indicated chlorophyll release following sonication, suggesting some cell disruption had occurred.

  5. A Network Disruption Modeling Tool

    National Research Council Canada - National Science Library

    Leinart, James

    1998-01-01

    Given that network disruption has been identified as a military objective and C2-attack has been identified as the mechanism to accomplish this objective, a target set must be acquired and priorities...

  6. Disruptive innovation: the demand side.

    Science.gov (United States)

    Havighurst, Clark C

    2008-01-01

    The notion of disruptive innovation provides a welcome framework for considering the prospects for low-cost alternatives in American medicine. Such innovations as have been seen, however, are largely the result of demand by patients paying their own bills because they have high-deductible coverage or are uninsured. Many other cost-saving innovations are discouraged by financing systems that are themselves largely immune to competition from disruptive innovators.

  7. Disruption studies on ASDEX upgrade

    International Nuclear Information System (INIS)

    Pautasso, G.; Egorov, S.; Finken, K.H.

    2003-01-01

    Disruptions generate large thermal and mechanical stresses on the tokamak components and are occasionally responsible for damages to the machine. For a future reactor disruptions have a significant impact on the design since all loading conditions must be analyzed in accordance with stricter design criteria (due to safety or difficult maintenance). Therefore the uncertainties affecting the predicted stresses must be reduced as much as possible with a more comprehensive set of measurements and analyses in this generation of experimental machines, and avoidance/predictive methods must be developed further. Disruption studies on ASDEX Upgrade are focused on these subjects, namely on: (1) understanding the physical mechanisms leading to this phenomenon in order to learn to avoid it or to predict its occurrence and to mitigate its effects; (2) analyzing the effects of disruptions on the machine to determine the functional dependence of the thermal and mechanical loads upon the discharge parameters. This allows, firstly, to dimension or reinforce the machine components to withstand these loads and, secondly, to extrapolate them to tokamaks still in the design phase; (3) learning to mitigate the consequence of disruptions, i.e. thermal loads, mechanical forces and runaways with injection of impurity pellets or gas. This paper is focused on most recent results concerning points, i.e. on the analysis of the degree of asymmetry of the forces and on the use of impurity puff for mitigation

  8. Disruptive event analysis: volcanism and igneous intrusion

    International Nuclear Information System (INIS)

    Crowe, B.M.

    1979-01-01

    Three basic topics are addressed for the disruptive event analysis: first, the range of disruptive consequences of a radioactive waste repository by volcanic activity; second, the possible reduction of the risk of disruption by volcanic activity through selective siting of a repository; and third, the quantification of the probability of repository disruption by volcanic activity

  9. Online Education Cast as "Disruptive Innovation"

    Science.gov (United States)

    Totter, Andrew

    2008-01-01

    Technology-based forces of "disruptive innovation" are gathering around public education and will overhaul the way K-12 students learn--with potentially dramatic consequences for established public schools, according to an upcoming book that draws parallels to disruptions in other industries. In his "Disrupting Class: How Disruptive Innovation…

  10. Professional Disruption in Health Regulation

    DEFF Research Database (Denmark)

    Hasselbalch, Jacob

    2016-01-01

    How do professions respond to fast-moving technological changes? Disruptive innovations overturn expectations about how markets function and develop, and they often raise moral, legal and scientific concerns among professionals. Sudden technological changes can result in a state of professional...... disruption, in which technological change challenges the institutional arrangements of a profession. This article distinguishes between fast and slow processes of professional change, focusing on the role of technology as one cause of fast changes to a profession. Professionals and non-professionals engage...... in framing contests that draw on cognitive, normative and relational keys to signal their expectations. It is in these framing contests that professionals run the risk of disruption. Drawing on interview data with key policy actors, I investigate electronic cigarettes regulation in the European Union and its...

  11. Major plasma disruptions in TNS

    International Nuclear Information System (INIS)

    Onega, R.J.; Becraft, W.R.; Bettis, E.S.

    1979-02-01

    Evaluation of the instrumentation and control of a power producing tokamak fusion reactor such as The Next Step (TNS) requires an assessment of the consequences of a major plasma disruption during reactor operation. The most important consequence of a disruption will be damage to the first wall from thermal and magnetic stress. Severe temperature gradients will cause thermal stress, placing a limit on the number of disruptions that can occur before the integrity of the wall is lost, and eddy currents induced in the wall will interact with the magnetic energy of the plasma and the →B/sub T/ field to create mechanical forces. Consequences to the ohmic heating (OH) coils, their power supplies, and other coils must also be taken into account

  12. Disrupting the Industry with Play

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2016-01-01

    or two ago. This is significantly disrupting the industry in several market sectors. This paper describes the components of the playware and embodied artificial intelligence research that has led to disruption in the industrial robotics sector, and which points to the next disruption of the health care......Decades of research into intelligent, playful technology and user-friendly man-machine interfaces has provided important insight into the creation of robotic systems and intelligent interactive systems which are much more user-friendly, safer and cheaper than what appeared possible merely a decade...... sector. This includes playful robotics, LEGO robots for kids, minimal robot systems, user-friendly, behavior-based, biomimetic, modular robotics and intelligent systems. The insight into these components and the use in synthesis for designing robots and intelligent systems allows anybody, anywhere...

  13. Disruptive Innovation in Healthcare & Rehabilitation

    DEFF Research Database (Denmark)

    Brooks, Anthony Lewis

    2014-01-01

    Disruption is a powerful body of theory that describes how people interact and react, how behavior is shaped, how organizational cultures form and influence decisions. Innovation is the process of translating an idea or invention into a product or service that creates value or for which customers...... will pay. Disruptive Innovation in context of the author’s body of work in healthcare and rehabilitation relates to how development of a cloud-based converged infrastructure resource, similar to that conceived in a national (Danish) study titled Humanics, can act as an accessible data and knowledge...

  14. JET and COMPASS asymmetrical disruptions

    Czech Academy of Sciences Publication Activity Database

    Gerasimov, S.N.; Abreu, P.; Baruzzo, M.; Drozdov, V.; Dvornova, A.; Havlíček, Josef; Hender, T.C.; Hronová-Bilyková, Olena; Kruezi, U.; Li, X.; Markovič, Tomáš; Pánek, Radomír; Rubinacci, G.; Tsalas, M.; Ventre, S.; Villone, F.; Zakharov, L.E.

    2015-01-01

    Roč. 55, č. 11 (2015), s. 113006-113006 ISSN 0029-5515 R&D Projects: GA MŠk(CZ) LM2011021 Institutional support: RVO:61389021 Keywords : tokamak * asymmetrical disruption * JET * COMPASS Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 4.040, year: 2015

  15. Disruption mitigation on Tore Supra

    International Nuclear Information System (INIS)

    Martin, G.; Sourd, F.; Saint-Laurent, F.; Bucalossi, J.; Eriksson, L.G.

    2004-01-01

    During disruptions, the plasma energy is lost on the first wall within 1 ms, forces up to hundred tons are applied to the structures and kA of electrons are accelerated up to 50 MeV (runaway electrons). Already sources of concern in present day tokamaks, extrapolation to ITER shows the necessity of mitigation procedures, to avoid serious damages to in-vessel components. Massive gas injection was proposed, and encouraging tests have been done on Textor and DIII-D. Similar experiments where performed on Tore Supra, with the goal to validate their effect on runaway electrons, observed during the majority of disruptions. 0.1 mole of helium was injected within 5 ms in ohmic plasmas, up to 1.2 MA, either stable, or in a pre-disruptive phase (argon puffing). Beneficial effects where obtained: reduction of the current fall rate and eddy currents, total disappearance of runaway electrons and easy recovery for the next pulse, without noticeable helium pollution of following plasmas. Analysis of the 4 ms period between injection and disruption indicates that to reach these goals, one need to inject enough helium to keep it only partially ionised. It corresponds to 0.1 g for Tore Supra, and extrapolate to hundreds of grams for ITER. (authors)

  16. Jogging Can Modify Disruptive Behaviors.

    Science.gov (United States)

    Allen, Jill I.

    1980-01-01

    Jogging was used to modify disruptive behavior as part of the classroom routine for 12 learning disabled elementary-grade boys. The number of incidents of each of five negative behaviors were reduced by half following the 10-minute jogging routine. (SBH)

  17. Will blockchain disrupt your business?

    OpenAIRE

    Schmeiss, Jessica

    2018-01-01

    Blockchain has been praised to be “the technology most likely to change the next decade of business”. The disruptive power of the blockchain technology is yet limited, says HIIG-researcher Jessica Schmeiss. Beyond the hype, there a opportunities for companies to make their current business models more cost-effective and more efficient.

  18. Marital Alternatives and Marital Disruption.

    Science.gov (United States)

    Udry, J. Richard

    1981-01-01

    Explores the usefulness of "marital alternatives" as a dimension in explaining marital stability, using longitudinal data from a panel of married, White, urban couples from 16 urban areas. Results indicated the dimension of marital alternatives appeared to be a better predictor of marital disruption than marital satisfaction. (Author/RC)

  19. Disruption mitigation on Tore Supra

    International Nuclear Information System (INIS)

    Martin, G.; Sourd, F.; Saint-Laurent, F.; Bucalossi, J.; Eriksson, L.G.

    2005-01-01

    During disruptions, the plasma energy is lost on the first wall within 1 ms, forces up to hundred tons are applied to the structures and kA of electrons are accelerated up to 50 MeV (runaway electrons). Already sources of concern in present day tokamaks, extrapolation to ITER shows the necessity of mitigation procedures, to avoid serious damages to in-vessel components. Massive gas injection was proposed, and encouraging tests have been done on Textor and DIII-D. Similar experiments where performed on Tore Supra, with the goal to validate their effect on runaway electrons, observed during the majority of disruptions. 0.1 mole of helium was injected within 5 ms in ohmic plasmas, up to 1.2 MA, either stable, or in a pre-disruptive phase (argon puffing). Beneficial effects where obtained: reduction of the current fall rate and eddy currents, total disappearance of runaway electrons and easy recovery for the next pulse, without noticeable helium pollution of following plasmas. Analysis of the 4 ms period between injection and disruption indicates that to reach these goals, one need to inject enough helium to keep it only partially ionised. It correspond to 0.1 g for Tore Supra, and extrapolate to hundred's of grams for ITER. (author)

  20. Supply disruption cost for power network planning

    International Nuclear Information System (INIS)

    Kjoelle, G.H.

    1992-09-01

    A description is given of the method of approach to calculate the total annual socio-economic cost of power supply disruption and non-supplied energy, included the utilities' cost for planning. The total socio-economic supply disruption cost is the sum of the customers' disruption cost and the utilities' cost for failure and disruption. The mean weighted disruption cost for Norway for one hour disruption is NOK 19 per kWh. The customers' annual disruption cost is calculated with basis in the specific disruption cost referred to heavy load (January) and dimensioning maximum loads. The loads are reduced by factors taking into account the time variations of the failure frequency, duration, the loads and the disruption cost. 6 refs

  1. Bodily illusions disrupt tactile sensations.

    Science.gov (United States)

    D'Amour, Sarah; Pritchett, Lisa M; Harris, Laurence R

    2015-02-01

    To accurately interpret tactile information, the brain needs to have an accurate representation of the body to which to refer the sensations. Despite this, body representation has only recently been incorporated into the study of tactile perception. Here, we investigate whether distortions of body representation affect tactile sensations. We perceptually altered the length of the arm and the width of the waist using a tendon vibration illusion and measured spatial acuity and sensitivity. Surprisingly, we found reduction in both tactile acuity and sensitivity thresholds when the arm or waist was perceptually altered, which indicates a general disruption of low-level tactile processing. We postulate that the disruptive changes correspond to the preliminary stage as the body representation starts to change and may give new insights into sensory processing in people with long-term or sudden abnormal body representation such as are found in eating disorders or following amputation.

  2. Disrupting the habit of interviewing

    Directory of Open Access Journals (Sweden)

    Eileen Honan

    2014-06-01

    Full Text Available This paper contributes to the growing domain of ‘post-qualitative’ research and experiments with a new (representational form to move away from traditional and clichéd descriptions of research methods. In this paper, I want to interrogate the category of interview, and the habit of interviewing, to disrupt the clichés, so as to allow thinking of different ways of writing/speaking/representing the interactions between researcher and researched that will breathe new life into qualitative inquiries. I will attempt to flatten and shred, destabilise and disrupt our common-sense ideas about interview, including those held most sacred to the qualitative community, that of anonymity and confidentiality, as well as the privilege of the ‘transcript’ in re-presenting interview data.

  3. Disruptive technologies in higher education

    Directory of Open Access Journals (Sweden)

    Michael Flavin

    2012-08-01

    Full Text Available This paper analyses the role of “disruptive” innovative technologies in higher education. In this country and elsewhere, Higher Education Institutions (HEIs have invested significant sums in learning technologies, with Virtual Learning Environments (VLEs being more or less universal, but these technologies have not been universally adopted and used by students and staff. Instead, other technologies not owned or controlled by HEIs are widely used to support learning and teaching. According to Christensen's theory of Disruptive Innovation, these disruptive technologies are not designed explicitly to support learning and teaching in higher education, but have educational potential. This study uses Activity Theory and Expansive Learning to analyse data regarding the impact of disruptive technologies. The data were obtained through a questionnaire survey about awareness and use of technologies, and through observation and interviews, exploring participants’ actual practice. The survey answers tended to endorse Disruptive Innovation theory, with participants establishing meanings for technologies through their use of them, rather than in keeping with a designer's intentions. Observation revealed that learners use a narrow range of technologies to support learning, but with a tendency to use resources other than those supplied by their HEIs. Interviews showed that participants use simple and convenient technologies to support their learning and teaching. This study identifies a contradiction between learning technologies made available by HEIs, and technologies used in practice. There is no evidence to suggest that a wide range of technologies is being used to support learning and teaching. Instead, a small range of technologies is being used for a wide range of tasks. Students and lecturers are not dependent on their HEIs to support learning and teaching. Instead, they self-select technologies, with use weighted towards established brands. The

  4. Engineering analysis of TFTR disruption

    International Nuclear Information System (INIS)

    Murray, J.G.; Rothe, K.E.; Bronner, G.

    1984-09-01

    This report covers an engineering approach quantifying the currents, forces, and times, as well as plasma position, for the worst-case disruption based on engineerign circuit assumptions for the plasma. As the plasma moves toward the wall during the current-decay phase of disruption, the wall currents affect the rate of movement and, hence, the decay time. The calculated structure-induced currents differ considerably from those calculated using a presently available criterion, which specifies that the plasma remains stationary in the center of the torus while decaying in 10 ms. This report outlines the method and basis for the engineering calculation used to determine the current and forces as a function of the circuit characteristics. It provides specific calculations for the Tokamak Fusion Test Reactor (TFTR) with variations in parameters such as the thermal decay time, the torus resistance, and plasma temperature during the current decay. The study reviews possible ways to reduce the disruption damage of TFTR by reducing the magnitude of the plasma external field energy that is absorbed by the plasma during the current decay

  5. Engineering analysis of TFTR disruption

    Energy Technology Data Exchange (ETDEWEB)

    Murray, J.G.; Rothe, K.E.; Bronner, G.

    1984-09-01

    This report covers an engineering approach quantifying the currents, forces, and times, as well as plasma position, for the worst-case disruption based on engineerign circuit assumptions for the plasma. As the plasma moves toward the wall during the current-decay phase of disruption, the wall currents affect the rate of movement and, hence, the decay time. The calculated structure-induced currents differ considerably from those calculated using a presently available criterion, which specifies that the plasma remains stationary in the center of the torus while decaying in 10 ms. This report outlines the method and basis for the engineering calculation used to determine the current and forces as a function of the circuit characteristics. It provides specific calculations for the Tokamak Fusion Test Reactor (TFTR) with variations in parameters such as the thermal decay time, the torus resistance, and plasma temperature during the current decay. The study reviews possible ways to reduce the disruption damage of TFTR by reducing the magnitude of the plasma external field energy that is absorbed by the plasma during the current decay.

  6. Disruptive innovation as an entrepreneurial process

    NARCIS (Netherlands)

    Chandra, Y.; Yang, S.-J.S.; Singh, P.; Prajogo, D.; O'Neill, P.; Rahman, S.

    2008-01-01

    Research on conditions and causal mechanisms that influence disruptive innovation has been relatively unexplored in the extant research in disruptive innovation. By re-conceptualizing disruptive innovation as an entrepreneurial process at product, firm and industry levels, this paper draws on

  7. Revision Hope: Writing Disruption in Composition Studies.

    Science.gov (United States)

    Jung, Julie

    1997-01-01

    Uses Roland Barthes's metaphor of the "punctum" to explore the transformative potential of disruptions. Argues that writing teachers have been trained to read disruption in texts and classrooms as "evidence of poor taste or failed pedagogy," but that disruptions delay closure and thereby create spaces wherein theories and…

  8. Disruption and Distinctiveness in Higher Education

    Science.gov (United States)

    Purcell, Wendy

    2014-01-01

    "Disruption"--while an evocative word triggering feelings of anxiety and perhaps even fear--also signals renewal and growth. The Higher Education (HE) sector in England has experienced some profound disruption over the years, and yet has emerged stronger and renewed in many ways. The impact of recent disruptive forces, from fees to the…

  9. Routine Responses to Disruption of Routines

    Science.gov (United States)

    Guha, Mahua

    2015-01-01

    "Organisational routines" is a widely studied research area. However, there is a dearth of research on disruption of routines. The few studies on disruption of routines discussed problem-solving activities that are carried out in response to disruption. In contrast, this study develops a theory of "solution routines" that are a…

  10. Fisheries-induced disruptive selection.

    Science.gov (United States)

    Landi, Pietro; Hui, Cang; Dieckmann, Ulf

    2015-01-21

    Commercial harvesting is recognized to induce adaptive responses of life-history traits in fish populations, in particular by shifting the age and size at maturation through directional selection. In addition to such evolution of a target stock, the corresponding fishery itself may adapt, in terms of fishing policy, technological progress, fleet dynamics, and adaptive harvest. The aim of this study is to assess how the interplay between natural and artificial selection, in the simplest setting in which a fishery and a target stock coevolve, can lead to disruptive selection, which in turn may cause trait diversification. To this end, we build an eco-evolutionary model for a size-structured population, in which both the stock׳s maturation schedule and the fishery׳s harvest rate are adaptive, while fishing may be subject to a selective policy based on fish size and/or maturity stage. Using numerical bifurcation analysis, we study how the potential for disruptive selection changes with fishing policy, fishing mortality, harvest specialization, life-history tradeoffs associated with early maturation, and other demographic and environmental parameters. We report the following findings. First, fisheries-induced disruptive selection is readily caused by commonly used fishing policies, and occurs even for policies that are not specific for fish size or maturity, provided that the harvest is sufficiently adaptive and large individuals are targeted intensively. Second, disruptive selection is more likely in stocks in which the selective pressure for early maturation is naturally strong, provided life-history tradeoffs are sufficiently consequential. Third, when a fish stock is overexploited, fisheries targeting only large individuals might slightly increase sustainable yield by causing trait diversification (even though the resultant yield always remains lower than the maximum sustainable yield that could be obtained under low fishing mortality, without causing disruptive

  11. Changing perspectives in medical practice: disruptive innovation.

    Science.gov (United States)

    Paterick, Zachary R; Pradhan, Sala R; Paterick, Timothy E; Waterhouse, Blake E

    2009-01-01

    Disruptive innovation represents a business model that identifies a market location and increases consumer options. Retail clinics may represent a disruptive healthcare innovation that identifies strategies to reduce the cost of healthcare at the primary care level. The future of healthcare demands disruptive innovation that will allow for the 50 million uninsured members of our society to receive medical care. Disruptive innovative solutions need to ensure access, quality, and reasonable cost. Retail clinics represent the tip of the iceberg in disruptive innovative thinking. The obstacles that retail clinics must solve will be lessons learned for those that identify future innovative techniques.

  12. Disruptive Innovation in Numerical Hydrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Waltz, Jacob I. [Los Alamos National Laboratory

    2012-09-06

    We propose the research and development of a high-fidelity hydrodynamic algorithm for tetrahedral meshes that will lead to a disruptive innovation in the numerical modeling of Laboratory problems. Our proposed innovation has the potential to reduce turnaround time by orders of magnitude relative to Advanced Simulation and Computing (ASC) codes; reduce simulation setup costs by millions of dollars per year; and effectively leverage Graphics Processing Unit (GPU) and future Exascale computing hardware. If successful, this work will lead to a dramatic leap forward in the Laboratory's quest for a predictive simulation capability.

  13. Incumbent response to disruptive innovation

    DEFF Research Database (Denmark)

    Kaulio, Matti; Thorén, Kent; Rohrbeck, René

    changes, however successful in minor business model adaptions. An implication hereof is that the business model concept as such has low predictive power in explaining success and failure and is in the need of an operationalization. In addition, the article discusses the relationship between technological...... in relation to disruptive change. In relation to technical change the case company has successfully in transferred its technology from one generation to the next during more than 20 years. In relation to business model change the case company has been proactive but not successful in major business model...... innovation and business innovation....

  14. Disruptive innovation for social change.

    Science.gov (United States)

    Christensen, Clayton M; Baumann, Heiner; Ruggles, Rudy; Sadtler, Thomas M

    2006-12-01

    Countries, organizations, and individuals around the globe spend aggressively to solve social problems, but these efforts often fail to deliver. Misdirected investment is the primary reason for that failure. Most of the money earmarked for social initiatives goes to organizations that are structured to support specific groups of recipients, often with sophisticated solutions. Such organizations rarely reach the broader populations that could be served by simpler alternatives. There is, however, an effective way to get to those underserved populations. The authors call it "catalytic innovation." Based on Clayton Christensen's disruptive-innovation model, catalytic innovations challenge organizational incumbents by offering simpler, good-enough solutions aimed at underserved groups. Unlike disruptive innovations, though, catalytic innovations are focused on creating social change. Catalytic innovators are defined by five distinct qualities. First, they create social change through scaling and replication. Second, they meet a need that is either overserved (that is, the existing solution is more complex than necessary for many people) or not served at all. Third, the products and services they offer are simpler and cheaper than alternatives, but recipients view them as good enough. Fourth, they bring in resources in ways that initially seem unattractive to incumbents. And fifth, they are often ignored, put down, or even encouraged by existing organizations, which don't see the catalytic innovators' solutions as viable. As the authors show through examples in health care, education, and economic development, both nonprofit and for-profit groups are finding ways to create catalytic innovation that drives social change.

  15. Tokamak disruption heat flux simulator

    International Nuclear Information System (INIS)

    Langhoff, M.; Hess, G.; Gahl, J.; Ingram, R.

    1990-01-01

    A coaxial plasma gun system, operating in the deflagration mode, has been built and fired at the University of New Mexico. This system, powered by a 100 kJ capacitor bank, was designed to give a variable pulse length of approximately 50-100 us. The gun is intended to deliver to a target an energy deposition density of 1 kJ per cm 2 via impact with a deuterium plasma possessing a highly directed energy. This system should simulate on the target, over an area of approximately 10 cm 2 , the heat flux of a tokamak plasma disruption on plasma facing components. Current diagnostics for the system are rather rudimentary but sufficient for determination of plasma pulse characteristics and energy transfer to target. Electrical measurements include bank voltage measured via resistive voltage dividers, and bank current measured via Rogowski coil. The shape of the plasma, its position relative to the target area, and the final impact area, is determined via open-shutter photography and the use of witness plates. Total energy deposited onto targets will be determined through simple calorimetry and careful target mass measurements. Preliminary results describing the ablation of carbon targets exposed to disruption like heat fluxes will be presented as well as a description of the experimental apparatus

  16. Current concepts in neuroendocrine disruption.

    Science.gov (United States)

    León-Olea, Martha; Martyniuk, Christopher J; Orlando, Edward F; Ottinger, Mary Ann; Rosenfeld, Cheryl; Wolstenholme, Jennifer; Trudeau, Vance L

    2014-07-01

    In the last few years, it has become clear that a wide variety of environmental contaminants have specific effects on neuroendocrine systems in fish, amphibians, birds and mammals. While it is beyond the scope of this review to provide a comprehensive examination of all of these neuroendocrine disruptors, we will focus on select representative examples. Organochlorine pesticides bioaccumulate in neuroendocrine areas of the brain that directly regulate GnRH neurons, thereby altering the expression of genes downstream of GnRH signaling. Organochlorine pesticides can also agonize or antagonize hormone receptors, adversely affecting crosstalk between neurotransmitter systems. The impacts of polychlorinated biphenyls are varied and in many cases subtle. This is particularly true for neuroedocrine and behavioral effects of exposure. These effects impact sexual differentiation of the hypothalamic-pituitary-gonadal axis, and other neuroendocrine systems regulating the thyroid, metabolic, and stress axes and their physiological responses. Weakly estrogenic and anti-androgenic pollutants such as bisphenol A, phthalates, phytochemicals, and the fungicide vinclozolin can lead to severe and widespread neuroendocrine disruptions in discrete brain regions, including the hippocampus, amygdala, and hypothalamus, resulting in behavioral changes in a wide range of species. Behavioral features that have been shown to be affected by one or more these chemicals include cognitive deficits, heightened anxiety or anxiety-like, sociosexual, locomotor, and appetitive behaviors. Neuroactive pharmaceuticals are now widely detected in aquatic environments and water supplies through the release of wastewater treatment plant effluents. The antidepressant fluoxetine is one such pharmaceutical neuroendocrine disruptor. Fluoxetine is a selective serotonin reuptake inhibitor that can affect multiple neuroendocrine pathways and behavioral circuits, including disruptive effects on reproduction and

  17. Current Concepts in Neuroendocrine Disruption

    Science.gov (United States)

    2014-01-01

    In the last few years, it has become clear that a wide variety of environmental contaminants have specific effects on neuroendocrine systems in fish, amphibians, birds and mammals. While it is beyond the scope of this review to provide a comprehensive examination of all of these neuroendocrine disruptors, we will focus on select representative examples. Organochlorine pesticides bioaccumulate in neuroendocrine areas of the brain that directly regulate GnRH neurons, thereby altering the expression of genes downstream of GnRH signaling. Organochlorine pesticides can also agonize or antagonize hormone receptors, adversely affecting crosstalk between neurotransmitter systems. The impacts of polychlorinated biphenyls are varied and in many cases subtle. This is particularly true for neuroedocrine and behavioral effects of exposure. These effects impact sexual differentiation of the hypothalamic-pituitary-gonadal axis, and other neuroendocrine systems regulating the thyroid, metabolic, and stress axes and their physiological responses. Weakly estrogenic and anti-androgenic pollutants such as bisphenol A, phthalates, phytochemicals, and the fungicide vinclozolin can lead to severe and widespread neuroendocrine disruptions in discrete brain regions, including the hippocampus, amygdala, and hypothalamus, resulting in behavioral changes in a wide range of species. Behavioral features that have been shown to be affected by one or more these chemicals include cognitive deficits, heightened anxiety or anxiety-like, sociosexual, locomotor, and appetitive behaviors. Neuroactive pharmaceuticals are now widely detected in aquatic environments and water supplies through the release of wastewater treatment plant effluents. The antidepressant fluoxetine is one such pharmaceutical neuroendocrine disruptor. Fluoxetine is a selective serotonin reuptake inhibitor that can affect multiple neuroendocrine pathways and behavioral circuits, including disruptive effects on reproduction and

  18. Current disruption in toroidal devices

    International Nuclear Information System (INIS)

    1979-07-01

    Attempts at raising the density or the plasma current in a tokamak above certain critical values generally result in termination of the discharge by a disruption. This sudden end of the plasma current and plasma confinement is accompanied by large induced voltages and currents in the outer structures which, in large tokamaks, can only be handled with considerable effort, and which will probably only be tolerable in reactors as rare accidents. Because of its crucial importance for the construction and operation of tokamaks, this phenomenon and its theoretical interpretation were the subject of a three-day symposium organized by the International Atomic Energy Agency and Max-Planck-Institut fuer Plasmaphysik at Garching from February 14 to 16. (orig./HT)

  19. CATASTROPHIC DISRUPTION OF COMET ISON

    Energy Technology Data Exchange (ETDEWEB)

    Keane, Jacqueline V.; Kleyna, Jan T.; Riesen, Timm-Emmanuel; Meech, Karen J. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Milam, Stefanie N.; Charnley, Steven B. [Astrochemistry Laboratory, NASA GSFC, MS 690, Greenbelt, MD 20771 (United States); Coulson, Iain M. [Joint Astronomy Center, 660 North Aohoku Place, Hilo, HI 96720 (United States); Sekanina, Zdenek [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Kracht, Rainer, E-mail: keane@ifa.hawaii.edu [Ostlandring 53, D-25335 Elmshorn, Schleswig-Holstein (Germany)

    2016-11-10

    We report submillimeter 450 and 850 μ m dust continuum observations for comet C/2012 S1 (ISON) obtained at heliocentric distances 0.31–0.08 au prior to perihelion on 2013 November 28 ( r {sub h} = 0.0125 au). These observations reveal a rapidly varying dust environment in which the dust emission was initially point-like. As ISON approached perihelion, the continuum emission became an elongated dust column spread out over as much as 60″ (>10{sup 5} km) in the anti-solar direction. Deconvolution of the November 28.04 850 μ m image reveals numerous distinct clumps consistent with the catastrophic disruption of comet ISON, producing ∼5.2 × 10{sup 10} kg of submillimeter-sized dust. Orbital computations suggest that the SCUBA-2 emission peak coincides with the comet's residual nucleus.

  20. Catastrophic Disruption of Comet ISON

    Science.gov (United States)

    Keane, Jacqueline V.; Milam, Stefanie N.; Coulson, Iain M.; Kleyna, Jan T.; Sekanina, Zdenek; Kracht, Rainer; Riesen, Timm-Emmanuel; Meech, Karen J.; Charnley, Steven B.

    2016-01-01

    We report submillimeter 450 and 850 microns dust continuum observations for comet C/2012 S1 (ISON) obtained at heliocentric distances 0.31-0.08 au prior to perihelion on 2013 November 28 (rh?=?0.0125 au). These observations reveal a rapidly varying dust environment in which the dust emission was initially point-like. As ISON approached perihelion, the continuum emission became an elongated dust column spread out over as much as 60? (greater than 10(exp 5) km in the anti-solar direction. Deconvolution of the November 28.04 850 microns image reveals numerous distinct clumps consistent with the catastrophic disruption of comet ISON, producing approximately 5.2?×?10(exp 10) kg of submillimeter-sized dust. Orbital computations suggest that the SCUBA-2 emission peak coincides with the comet's residual nucleus.

  1. Automatic location of disruption times in JET.

    Science.gov (United States)

    Moreno, R; Vega, J; Murari, A

    2014-11-01

    The loss of stability and confinement in tokamak plasmas can induce critical events known as disruptions. Disruptions produce strong electromagnetic forces and thermal loads which can damage fundamental components of the devices. Determining the disruption time is extremely important for various disruption studies: theoretical models, physics-driven models, or disruption predictors. In JET, during the experimental campaigns with the JET-C (Carbon Fiber Composite) wall, a common criterion to determine the disruption time consisted of locating the time of the thermal quench. However, with the metallic ITER-like wall (JET-ILW), this criterion is usually not valid. Several thermal quenches may occur previous to the current quench but the temperature recovers. Therefore, a new criterion has to be defined. A possibility is to use the start of the current quench as disruption time. This work describes the implementation of an automatic data processing method to estimate the disruption time according to this new definition. This automatic determination allows both reducing human efforts to locate the disruption times and standardizing the estimates (with the benefit of being less vulnerable to human errors).

  2. Survey of disruption causes at JET

    NARCIS (Netherlands)

    de Vries, P. C.; Johnson, M. F.; Alper, B.; Buratti, P.; Hender, T. C.; Koslowski, H. R.; Riccardo, V.

    2011-01-01

    A survey has been carried out into the causes of all 2309 disruptions over the last decade of JET operations. The aim of this survey was to obtain a complete picture of all possible disruption causes, in order to devise better strategies to prevent or mitigate their impact. The analysis allows the

  3. Recovery of Disruptions in Rapid Transit Networks

    NARCIS (Netherlands)

    Cadarso, L.; Marin, A.; Maroti, G.

    2013-01-01

    This paper studies the disruption management problem of rapid transit rail networks. Besides optimizing the timetable and the rolling stock schedules, we explicitly deal with the effects of the disruption on the passenger demand.We propose a two-step approach that combines an integrated optimization

  4. Disruption Management in Passenger Railway Transportation

    DEFF Research Database (Denmark)

    Groth, Julie Jespersen; Potthoff, Daniel; Clausen, Jens

    2009-01-01

    This paper deals with disruption management in passenger railway transportation. In the disruption management process, many actors belonging to different organizations play a role. In this paper we therefore describe the process itself and the roles of the different actors. Furthermore, we discus...

  5. Disruptive School Peers and Student Outcomes

    DEFF Research Database (Denmark)

    Kristoffersen, Jannie H. G.; Krægpøth, Morten Visby; Skyt Nielsen, Helena

    identify three groups of potentially disruptive and emotionally sensitive children from detailed Danish register data: children with divorced parents, children with parents convicted of crime, and children with a psychiatric diagnosis. We find that adding potentially disruptive children lowers the academic...... achievement of peers by about 1.5-2 percent of a standard deviation....

  6. Disrupted Sleep: From Molecules to Cognition

    NARCIS (Netherlands)

    van Someren, E.J.; Cirelli, C.; Dijk, D.J.; Van Cauter, E.; Schwartz, S.; Chee, M.W.L.

    2015-01-01

    Although the functions of sleep remain to be fully elucidated, it is clear that there are far-reaching effects of its disruption, whether by curtailment for a single night, by a few hours each night over a long period, or by disruption in sleep continuity. Epidemiological and experimental studies of

  7. Disrupted Sleep : From Molecules to Cognition

    NARCIS (Netherlands)

    Van Someren, Eus J W; Cirelli, Chiara; Dijk, Derk-Jan; Van Cauter, Eve; Schwartz, Sophie; Chee, Michael W L

    2015-01-01

    UNLABELLED: Although the functions of sleep remain to be fully elucidated, it is clear that there are far-reaching effects of its disruption, whether by curtailment for a single night, by a few hours each night over a long period, or by disruption in sleep continuity. Epidemiological and

  8. Disruptive School Peers and Student Outcomes

    DEFF Research Database (Denmark)

    Kristoffersen, Jannie H. G.; Krægpøth, Morten Visby; Nielsen, Helena Skyt

    2015-01-01

    identify three groups of potentially disruptive and emotionally sensitive children from detailed Danish register data: children with divorced parents, children with parents convicted of crime, and children with a psychiatric diagnosis. We find that adding potentially disruptive children lowers the academic...

  9. Disruptive School Peers and Student Outcomes

    DEFF Research Database (Denmark)

    Kristoffersen, Jannie H. G.; Krægpøth, Morten Visby; Skyt Nielsen, Helena

    identify three groups of potentially disruptive and emotionally sensitive children from detailed Danish register data: children with divorced parents, children with parents convicted of crime, and children with a psychiatric diagnosis. We find that adding potentially disruptive children lowers the academic...

  10. Resistance to Disruption in a Classroom Setting

    Science.gov (United States)

    Parry-Cruwys, Diana E.; Neal, Carrie M.; Ahearn, William H.; Wheeler, Emily E.; Premchander, Raseeka; Loeb, Melissa B.; Dube, William V.

    2011-01-01

    Substantial experimental evidence indicates that behavior reinforced on a denser schedule is more resistant to disruption than is behavior reinforced on a thinner schedule. The present experiment studied resistance to disruption in a natural educational environment. Responding during familiar activities was reinforced on a multiple…

  11. Plasma membrane disruption: repair, prevention, adaptation

    Science.gov (United States)

    McNeil, Paul L.; Steinhardt, Richard A.

    2003-01-01

    Many metazoan cells inhabit mechanically stressful environments and, consequently, their plasma membranes are frequently disrupted. Survival requires that the cell rapidly repair or reseal the disruption. Rapid resealing is an active and complex structural modification that employs endomembrane as its primary building block, and cytoskeletal and membrane fusion proteins as its catalysts. Endomembrane is delivered to the damaged plasma membrane through exocytosis, a ubiquitous Ca2+-triggered response to disruption. Tissue and cell level architecture prevent disruptions from occurring, either by shielding cells from damaging levels of force, or, when this is not possible, by promoting safe force transmission through the plasma membrane via protein-based cables and linkages. Prevention of disruption also can be a dynamic cell or tissue level adaptation triggered when a damaging level of mechanical stress is imposed. Disease results from failure of either the preventive or resealing mechanisms.

  12. Mechanistic evaluation of endocrine disrupting chemicals

    DEFF Research Database (Denmark)

    Taxvig, Camilla

    BACKGROUND: This PhD project is part of the research area concerning effects of endocrine disrupters at the National Food Institute at DTU in Denmark. Endocrine disrupting chemicals (EDCs) have proved to be important for improper development of the male reproductive organs and subsequent for the ......BACKGROUND: This PhD project is part of the research area concerning effects of endocrine disrupters at the National Food Institute at DTU in Denmark. Endocrine disrupting chemicals (EDCs) have proved to be important for improper development of the male reproductive organs and subsequent...... metabolising system using liver S9 mixtures or hepatic rat microsomes could be a convenient method for the incorporation of metabolic aspects into in vitro testing for endocrine disrupting effects....

  13. Allosteric Inhibition Through Core Disruption

    Energy Technology Data Exchange (ETDEWEB)

    Horn, James R.; Shoichet, Brian K. (NWU); (UCSF)

    2010-03-05

    Although inhibitors typically bind pre-formed sites on proteins, it is theoretically possible to inhibit by disrupting the folded structure of a protein or, in the limit, to bind preferentially to the unfolded state. Equilibria defining how such molecules act are well understood, but structural models for such binding are unknown. Two novel inhibitors of {beta}-lactamase were found to destabilize the enzyme at high temperatures, but at lower temperatures showed no preference for destabilized mutant enzymes versus stabilized mutants. X-ray crystal structures showed that both inhibitors bound to a cryptic site in {beta}-lactamase, which the inhibitors themselves created by forcing apart helixes 11 and 12. This opened up a portion of the hydrophobic core of the protein, into which these two inhibitors bind. Although this binding site is 16 {angstrom} from the center of the active site, the conformational changes were transmitted through a sequence of linked motions to a key catalytic residue, Arg244, which in the complex adopts conformations very different from those in catalytically competent enzyme conformations. These structures offer a detailed view of what has heretofore been a theoretical construct, and suggest the possibility for further design against this novel site.

  14. Report on Criteria for Endocrine Disrupters

    DEFF Research Database (Denmark)

    Holbech, Henrik

    2011-01-01

    This report has been prepared by the Danish Centre on Endocrine Disrupters as a project contracted by the Danish Environmental Protection Agency. The Danish Centre on Endocrine Disrupters is an interdisciplinary scientific network without walls. The main purpose of the Centre is to build and gather....... The overall aim of this project is to provide a science based proposal for criteria for endocrine disrupters. The terms of reference for the project specify elements to be included and/or addressed when developing the criteria (Annex 1). Also, several international reports and papers dealing with assessment...

  15. The Effects of Disruption on Strategic Management

    DEFF Research Database (Denmark)

    Drejer, Anders

    2017-01-01

    , Digitalization, Globalization and much more. Furthermore, the effects of disruption are now being felt by organizations and industries all over the world. In this paper, we will try to outline and illustrate some of those effects using the case-study of an international, Danish, SME. The case company has been...... forced to face some challenges caused by disruption and in the process of doing so has changed its strategy process significantly towards a more learning based approach to strategic management. Keywords: disruption; case- study; SME; strategy process....

  16. Periodic disruptions in the MT-1 tokamak

    International Nuclear Information System (INIS)

    Zoletnik, S.

    1988-11-01

    Disruptive instabilities are common phenomena in toroidal devices, especially in tokamaks. Three types can be distinguished: internal, minor and major disruptions. Periodic minor disruptions in the MT-1 tokamak were measured systematically with values of the limiter safety factor between 4 and 10. The density limit as a function of plasma current and horizontal displacement was investigated. Precursor oscillations always appear before the instability with increasing amplitude but can be observed at the density limit with quasi-stationary amplitude. Phase correlation between precursor oscillations were measured with Mirnov coils and x-ray detectors, and they show good agreement with a simple magnetic island model. (R.P.) 11 refs.; 6 figs

  17. Visual in-pile fuel disruption experiments

    International Nuclear Information System (INIS)

    Cano, G.L.; Ostensen, R.W.; Young, M.F.

    1978-01-01

    In a loss-of-flow (LOF) accident in an LMFBR, the mode of disruption of fuel may determine the probability of a subsequent energetic excursion. To investigate these phenomena, in-pile disruption of fission-heated irradiated fuel pellets was recorded by high speed cinematography. Instead of fuel frothing or dust-cloud breakup (as used in the SAS code) massive and very rapid fuel swelling, not predicted by analytical models, occurred. These tests support massive fuel swelling as the initial mode of fuel disruption in a LOF accident. (author)

  18. Erosion products in disruption simulation experiments

    Energy Technology Data Exchange (ETDEWEB)

    Safronov, V.; Arkhipov, N.; Bakhtin, V.; Barsuk, V.; Kurkin, S.; Mironova, E.; Toporkov, D.; Vasenin, S.; Zhitlukhin, A. [Troitsk Inst. for Innovation and Fusion Research, Troisk, Moscow region (Russian Federation); Arkhipov, I. [Inst. of Physical Chemistry, Russian Academy of Science, Moscow (Russian Federation); Werle, H.; Wuerz, H. [Forschungszentrum Karlsruhe (Germany)

    1998-07-01

    Erosion of divertor materials under tokamak disruption event presents a serious problem of ITER technology. Erosion restricts the divertor lifetime and leads to production of redeposited layers of the material retaining large amount of tritium, which is a major safety issue for future fusion reactor. Since ITER disruptive heatloads are not achievable in existing tokamaks, material erosion is studied in special simulation experiments. Till now the simulation experiments have focused mainly on investigation of shielding effect and measurement of erosion rate. In the present work the properties of eroded and redeposited graphite are studied under condition typical for hard ITER disruption. (author)

  19. Disruptions and Their Mitigation in TEXTOR

    International Nuclear Information System (INIS)

    Finken, K.H.; Jaspers, R.; Kraemer-Flecken, A.; Savtchkov, A.; Lehnen, M.; Waidmann, G.

    2005-01-01

    Disruptions remain a major concern for tokamak devices, particularly for large machines. The critical issues are the induced (halo) currents and the resulting forces, the excessive heating of exposed surfaces by the instantaneous power release, and the possible occurrence of highly energetic runaway electrons. The key topics of the investigations on TEXTOR in the recent years concerned (a) the power deposition pattern recorded by a fast infrared scanner, (b) the runaway generation measured by synchrotron radiation in the infrared spectral region, (c) method development for 'healing' discharges that are going to disrupt, and (d) massive gas puffing for mitigating the adverse effects of disruptions

  20. Disruptions, disruptivity and safer operating windows in the high-β spherical torus NSTX

    International Nuclear Information System (INIS)

    Gerhardt, S.P.; Bell, R.E.; Diallo, A.; Gates, D.; LeBlanc, B.P.; Menard, J.E.; Mueller, D.; Sabbagh, S.A.; Soukhanovskii, V.; Tritz, K.; Yuh, H.

    2013-01-01

    This paper discusses disruption rates, disruption causes and disruptivity statistics in the high-β N National Spherical Torus Experiment (NSTX) (Ono et al 2000 Nucl. Fusion 40 557). While the overall disruption rate is rather high, configurations with high β N , moderate q * , strong boundary shaping, sufficient rotation and broad pressure and current profiles are found to have the lowest disruptivity; active n = 1 control further reduces the disruptivity. The disruptivity increases rapidly for q * min > 1.25 is generally acceptable for avoiding the onset of core rotating n = 1 kink/tearing modes; when EPM and ELM disturbances are present, the required q min for avoiding those modes is raised to ∼1.5. The current ramp and early flat-top phase of the discharges are prone to n = 1 core rotating modes locking to the wall, leading to a disruption. Small changes to the discharge fuelling during this phase can often mitigate the rotation damping associated with these modes and eliminate the disruption. The largest stored-energy disruptions are those that occur at high current when a plasma current ramp-down is initiated incorrectly. (paper)

  1. Towards a Framework of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    2014-01-01

    Digital platforms are disruptive information technology (IT) artifacts that erode conventional business logic associated with traditional market structures. This paper presents a framework for examining the disruptive potential of digital platforms whereby we postulate that the strategic interplay...... of governance regimes and platform layers is deterministic of whether disruptive derivatives are permitted to flourish. This framework has been employed in a comparative case study between centralized (i.e., PayPal) and decentralized (i.e., Coinkite) digital payment platforms to illustrate its applicability...... and yield propositions on the nature and impact of digital platform disruptions. Preliminary findings indicate that centralized digital platforms attempt to create unique configurals to obtain monopolistic power by tightly coupling platform layers, which are difficult to replicate. Conversely, decentralized...

  2. The Logic of Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties (e.g., apps). This study endeavours to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market...... environments. We postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation...... is permitted. To shed light on the disruptive potential of digital platforms, we opted for payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  3. Runaway electron generation in tokamak disruptions

    Energy Technology Data Exchange (ETDEWEB)

    Helander, P. [EURATOM/UKAEA Fusion Association, Culham Science Centre, Abingdon (United Kingdom); Andersson, F.; Fulop, T.; Smith, T.H.; Anderson, D.; Lisak, M. [Chalmers Univ. of Technology, Dept. of Electromagnetics, Goteborg (Sweden); Eriksson, L.G. [Euratom-CEA, Centre d' Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Recherches sur la Fusion Controlee

    2004-07-01

    The time evolution of the plasma current during a tokamak disruption is calculated by solving the equations for runaway electron production simultaneously with the induction equation for the toroidal electric field. The resistive diffusion time in a post-disruption plasma is typically comparable to the runaway avalanche growth time. Accordingly, the toroidal electric field induced after the thermal quench of a disruption diffuses radially through the plasma at the same time as it accelerates runaway electrons, which in turn back-react on the electric field. When these processes are accounted for in a self-consistent way, it is found that (1) the efficiency and time scale of runaway generation agrees with JET experiments; (2) the runaway current profile typically becomes more peaked than the pre-disruption current profile; and (3) can easily become radially in the shape of filaments. It is also shown that higher runaway electron generation is expected if the thermal quench is sufficiently fast. (authors)

  4. Disruption Management in Passenger Railway Transportation

    DEFF Research Database (Denmark)

    Jespersen-Groth, Julie; Potthoff, Daniel; Clausen, Jens

    This paper deals with disruption management in passenger railway transportation. In the disruption management process, many actors belonging to different organizations play a role. In this paper we therefore describe the process itself and the roles of the different actors. Furthermore, we discus...... for related problems in the airline world are discussed as well. Finally, we address the integration of the re-scheduling processes of the timetable, and the resources rolling stock and crew....

  5. BINARY DISRUPTION BY MASSIVE BLACK HOLES: HYPERVELOCITY STARS, S STARS, AND TIDAL DISRUPTION EVENTS

    Energy Technology Data Exchange (ETDEWEB)

    Bromley, Benjamin C. [Department of Physics and Astronomy, University of Utah, 115 S 1400 E, Rm 201, Salt Lake City, UT 84112 (United States); Kenyon, Scott J.; Geller, Margaret J.; Brown, Warren R., E-mail: bromley@physics.utah.edu, E-mail: skenyon@cfa.harvard.edu, E-mail: mgeller@cfa.harvard.edu, E-mail: wbrown@cfa.harvard.edu [Smithsonian Astrophysical Observatory, 60 Garden Street, Cambridge, MA 02138 (United States)

    2012-04-20

    We examine whether disrupted binary stars can fuel black hole growth. In this mechanism, tidal disruption produces a single hypervelocity star (HVS) ejected at high velocity and a former companion star bound to the black hole. After a cluster of bound stars forms, orbital diffusion allows the black hole to accrete stars by tidal disruption at a rate comparable to the capture rate. In the Milky Way, HVSs and the S star cluster imply similar rates of 10{sup -5} to 10{sup -3} yr{sup -1} for binary disruption. These rates are consistent with estimates for the tidal disruption rate in nearby galaxies and imply significant black hole growth from disrupted binaries on 10 Gyr timescales.

  6. An Ecological Perspective on Sleep Disruption.

    Science.gov (United States)

    Tougeron, Kévin; Abram, Paul K

    2017-09-01

    Despite its evolutionary importance and apparent ubiquity among animals, the ecological significance of sleep is largely unresolved. The ecology of sleep has been particularly neglected in invertebrates. In insects, recent neurobehavioral research convincingly demonstrates that resting behavior shares several common characteristics with sleep in vertebrates. Laboratory studies have produced compelling evidence that sleep disruption can cause changes in insect daily activity patterns (via "sleep rebound") and have consequences for behavioral performance during active periods. However, factors that could cause insect sleep disruption in nature have not been considered nor have the ecological consequences. Drawing on evidence from laboratory studies, we argue that sleep disruption may be an overlooked component of insect ecology and could be caused by a variety of anthropogenic and nonanthropogenic factors in nature. We identify several candidate sleep-disrupting factors and provide new insights on the potential consequences of sleep disruption on individual fitness, species interactions, and ecosystem services. We propose an experimental framework to bridge the current gap in knowledge between laboratory and field studies. We conclude that sleep disruption is a potential mechanism underpinning variation in behavioral, population, and community-level processes associated with several aspects of global change.

  7. Airline Disruption Management - Perspectives, Experiences and Outlook

    DEFF Research Database (Denmark)

    Kohl, Niklas; Larsen, Allan; Larsen, Jesper

    2004-01-01

    Over the past decade, airlines have become more concerned with developing an optimal flight schedule, with very little slack left to accommodate for any form of variation from the optimal solution. During operation the planned schedules often have to be revised due to disruptions caused by for ex......Over the past decade, airlines have become more concerned with developing an optimal flight schedule, with very little slack left to accommodate for any form of variation from the optimal solution. During operation the planned schedules often have to be revised due to disruptions caused...... by for example severe weather, technical problems and crew sickness. Thus, the field of Airline Disruption Management has emerged within the past few years. The increased focus on cutting cost at the major airlines has intensified the interest in the development of new and cost e cient methods to handle airline...... disruptions. The purpose of this paper is twofold. In the first part it o ers an introduction to airline disruption management, provides the readers with a description of the planning processes and delivers a detailed overview of the numerous aspects of airline disruption management. In the second part we...

  8. Airline Disruption Management - Perspectives, Experiences and Outlook

    DEFF Research Database (Denmark)

    Kohl, Niklas; Larsen, Allan; Larsen, Jesper

    2007-01-01

    Over the past decade, airlines have become more concerned with developing an optimal flight schedule, with very little slack left to accommodate for any form of variation from the optimal solution. During operation the planned schedules often have to be revised due to disruptions caused by for ex......Over the past decade, airlines have become more concerned with developing an optimal flight schedule, with very little slack left to accommodate for any form of variation from the optimal solution. During operation the planned schedules often have to be revised due to disruptions caused...... by for example severe weather, technical problems and crew sickness. Thus, the field of Airline Disruption Management has emerged within the past few years. The increased focus on cutting cost at the major airlines has intensified the interest in the development of new and cost efficient methods to handle...... airline disruptions. The purpose of this paper is twofold. In the first part it offers an introduction to airline disruption management provides the readers with a description of the planning processes and delivers a detailed overview of the numerous aspects of airline disruption management. In the second...

  9. MHD stability, operational limits and disruptions

    International Nuclear Information System (INIS)

    1999-01-01

    The present physics understandings of magnetohydrodynamic (MHD) stability of tokamak plasmas, the threshold conditions for onset of MHD instability, and the resulting operational limits on attainable plasma pressure (beta limit) and density (density limit), and the consequences of plasma disruption and disruption related effects are reviewed and assessed in the context of their application to a future DT burning reactor prototype tokamak experiment such as ITER. The principal considerations covered within the MHD stability and beta limit assessments are (i) magnetostatic equilibrium, ideal MHD stability and the resulting ideal MHD beta limit; (ii) sawtooth oscillations and the coupling of sawtooth activity to other types of MHD instability; (iii) neoclassical island resistive tearing modes and the corresponding limits on beta and energy confinement; (iv) wall stabilization of ideal MHD instabilities and resistive wall instabilities; (v) mode locking effects of non-axisymmetric error fields; (vi) edge localized MHD instabilities (ELMs, etc.); and (vii) MHD instabilities and beta/pressure gradient limits in plasmas with actively modified current and magnetic shear profiles. The principal considerations covered within the density limit assessments are (i) empirical density limits; (ii) edge power balance/radiative density limits in ohmic and L-mode plasmas; and (iii) edge parameter related density limits in H-mode plasmas. The principal considerations covered in the disruption assessments are (i) disruption causes, frequency and MHD instability onset; (ii) disruption thermal and current quench characteristics; (iii) vertical instabilities (VDEs), both before and after disruption, and plasma and in-vessel halo currents; (iv) after disruption runaway electron formation, confinement and loss; (v) fast plasma shutdown (rapid externally initiated dissipation of plasma thermal and magnetic energies); (vi) means for disruption avoidance and disruption effect mitigation; and

  10. Mechanical algal disruption for efficient biodiesel extraction

    Science.gov (United States)

    Krehbiel, Joel David

    Biodiesel from algae provides several benefits over current biodiesel feedstocks, but the energy requirements of processing algae into a useable fuel are currently so high as to be prohibitive. One route to improving this is via disruption of the cells prior to lipid extraction, which can significantly increase energy recovery. Unfortunately, several obvious disruption techniques require more energy than can be gained. This dissertation examines the use of microbubbles to improve mechanical disruption of algal cells using experimental, theoretical, and computational methods. New laboratory experiments show that effective ultrasonic disruption of algae is achieved by adding microbubbles to an algal solution. The configuration studied flows the solution through a tube and insonifies a small section with a high-pressure ultrasound wave. Previous biomedical research has shown effective cell membrane damage on animal cells with similar methods, but the present research is the first to extend such study to algal cells. Results indicate that disruption increases with peak negative pressure between 1.90 and 3.07 MPa and with microbubble concentration up to 12.5 x 107 bubbles/ml. Energy estimates of this process suggest that it requires only one-fourth the currently most-efficient laboratory-scale disruption process. Estimates of the radius near each bubble that causes disruption (i.e. the disruption radius) suggest that it increases with peak negative pressure and is near 9--20 microm for all cases tested. It is anticipated that these procedures can be designed for better efficiency and efficacy, which will be facilitated by identifying the root mechanisms of the bubble-induced disruption. We therefore examine whether bubble expansion alone creates sufficient cell deformation for cell rupture. The spherically-symmetric Marmottant model for bubble dynamics allows estimation of the flow regime under experimental conditions. Bubble expansion is modeled as a point source of

  11. Effect of music on mealtime disruptions.

    Science.gov (United States)

    Hooper, Jeff; Carson, Derek; Lindsay, Bill

    People with learning disabilities can disrupt mealtimes with non-cooperative, aggressive and self-injurious behaviours that challenge other people to tolerate and manage them. These behaviours appear to arise because the proximity of other people, and the heightened activity and noise of a dining room, causes anxiety and agitation. To examine how delivering calming background music via headphones affected anxiety-driven behaviours that disrupted mealtimes. A sample of 30 adults with mild, moderate or severe learning disabilities were videotaped during mealtimes on two consecutive days. On the first day, half the group ate without any calming music while the other half sat opposite them wearing earphones and listening to calming music. On the second day, the non-music and music groups swapped around. Of the participants who tolerated the earphones, only three showed disruptive behaviour; all three had been sitting at the table waiting for their food. With so few examples, meaningful inferential analysis was not possible. However, there were signs that calming music had a positive effect on disruptive mealtime behaviours. It eliminated physical harm, complaining and verbal repetition in one person, and stopped another from shouting/swearing. It also reduced the incidence of shouting/swearing, restlessness and vocalising. Calming music and reduced waiting at tables for food may reduce disruptive behaviours.

  12. Disruptive Intelligence - How to gather Information to deal with disruptive innovations

    NARCIS (Netherlands)

    Vriens, D.J.; Solberg Søilen, K.

    2014-01-01

    Disruptive innovations are innovations that have the capacity to transform a whole business into one with products that are more accessible and affordable (cf. Christensen et al. 2009). As Christensen et al. argue no business is immune to such disruptive innovations. If these authors are right, it

  13. Tidal Disruption Events from Eccentric Nuclear Disks

    Science.gov (United States)

    Wernke, Heather N.; Madigan, Ann-Marie

    2018-04-01

    Stars that get too close to a supermassive black hole are in danger of being tidally disrupted. Stellar two-body relaxation is commonly assumed to be the main driver of these events. Recent work has shown, however, that secular gravitational torques from eccentric nuclear disks can push stars to extreme eccentricities at much higher rates than predicted by two-body relaxation. This work did not include the effects of general relativity, however, which could quench secular torques via rapid apsidal precession. Here we show that, for a star in danger of disruption, general relativity acts on a timescale of less than an orbital period. This short timescale means that general relativity does not have enough time to have a major effect on the orbit. When driven by secular torques from eccentric nuclear disks, tidal disruption event rates are not affected by general relativity.

  14. From Digital Disruption to Business Model Scalability

    DEFF Research Database (Denmark)

    Nielsen, Christian; Lund, Morten; Thomsen, Peter Poulsen

    2017-01-01

    as a response to digital disruption. A series of case studies illustrate that besides frequent existing messages in the business literature relating to the importance of creating agile businesses, both in growing and declining economies, as well as hard to copy value propositions or value propositions that take...... a long time to replicate, business model scalability can be cornered into four dimensions. In many corporate restructuring exercises and Mergers and Acquisitions there is a tendency to look for synergies in the form of cost reductions, lean workflows and market segments. However, this state of mind......This article discusses the terms disruption, digital disruption, business models and business model scalability. It illustrates how managers should be using these terms for the benefit of their business by developing business models capable of achieving exponentially increasing returns to scale...

  15. Density turbulence and disruption phenomena in TEXTOR

    International Nuclear Information System (INIS)

    Waidmann, G.; Kuang, G.; Jadoul, M.

    1992-01-01

    Disruptive processes are observed in tokamak plasmas not only at the operating limits (density limit or q-limit) but can be found under a variety of experimental conditions. Large forces are exerted then on vessel components and support structures. The sudden release of stored plasma energy presents a serious erosion problem for the first wall already in the next generation of large tokamak machines. Strong energy losses from the plasma and an influx of impurities are already present in minor plasma disruptions which do not immediately lead to a plasma current termination. The rapid loss of energy confinement was investigated within the framework of a systematic study on plasma disruption phenomena in TEXTOR. (author) 4 refs., 4 figs

  16. Disruption effects on the beam size measurement

    International Nuclear Information System (INIS)

    Raimondi, P.; Decker, F.J.; Chen, P.

    1995-01-01

    At the SLC Final Focus with higher currents and smaller beam sizes, the disruption parameter D y is close to one and so the pinch effect should produce a luminosity enhancement. Since a flat beam-beam function is fit to deflection scan data to measure the beam size, disruption can affect the measurement. Here the authors discuss the quantitative effects of disruption for typical SLC beam parameters. With 3.5 10 10 particles per pulse, bunch length of 0.8 mm and beam sizes of 2.1 μm horizontally and 0.55 μm vertically, the measured vertical size can be as much as 25% bigger than the real one. Furthermore during the collision the spot size actually decrease, producing an enhancement factor H D of about 1.25. This would yield to a true luminosity which is 1.6 times that which is estimated from the beam-beam deflection fit

  17. Mechanisms of Memory Disruption in Depression.

    Science.gov (United States)

    Dillon, Daniel G; Pizzagalli, Diego A

    2018-03-01

    Depressed individuals typically show poor memory for positive events, potentiated memory for negative events, and impaired recollection. These phenomena are clinically important but poorly understood. Compelling links between stress and depression suggest promising candidate mechanisms. Stress can suppress hippocampal neurogenesis, inhibit dopamine neurons, and sensitize the amygdala. We argue that these phenomena may impair pattern separation, disrupt the encoding of positive experiences, and bias retrieval toward negative events, respectively, thus recapitulating core aspects of memory disruption in depression. Encouragingly, optogenetic reactivation of cells engaged during the encoding of positive memories rapidly reduces depressive behavior in preclinical models. Thus, many memory deficits in depression appear to be downstream consequences of chronic stress, and addressing memory disruption can have therapeutic value. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Isolated Sleep Paralysis: Fear, Prevention, and Disruption.

    Science.gov (United States)

    Sharpless, Brian Andrew; Grom, Jessica Lynn

    2016-01-01

    Relatively little is known about isolated sleep paralysis (ISP), and no empirically supported treatments are available. This study aims to determine: the clinical impact of ISP, the techniques used to prevent or disrupt ISP, and the effectiveness of these techniques. 156 undergraduates were assessed with lifetime ISP using a clinical interview. 75.64% experienced fear during ISP, and 15.38% experienced clinically significant distress/interference, while 19.23% attempted to prevent ISP, and 79.31% of these believed their methods were successful. Regarding disruption, 69.29% made attempts, but only 54.12% reported them effective. Disruption was more common than prevention, but several techniques were useful. Encouraging individuals to utilize these techniques and better monitor their symptoms may be an effective way to manage problematic ISP.

  19. Analytic modeling of axisymmetric disruption halo currents

    International Nuclear Information System (INIS)

    Humphreys, D.A.; Kellman, A.G.

    1999-01-01

    Currents which can flow in plasma facing components during disruptions pose a challenge to the design of next generation tokamaks. Induced toroidal eddy currents and both induced and conducted poloidal ''halo'' currents can produce design-limiting electromagnetic loads. While induction of toroidal and poloidal currents in passive structures is a well-understood phenomenon, the driving terms and scalings for poloidal currents flowing on open field lines during disruptions are less well established. A model of halo current evolution is presented in which the current is induced in the halo by decay of the plasma current and change in enclosed toroidal flux while being convected into the halo from the core by plasma motion. Fundamental physical processes and scalings are described in a simplified analytic version of the model. The peak axisymmetric halo current is found to depend on halo and core plasma characteristics during the current quench, including machine and plasma dimensions, resistivities, safety factor, and vertical stability growth rate. Two extreme regimes in poloidal halo current amplitude are identified depending on the minimum halo safety factor reached during the disruption. A 'type I' disruption is characterized by a minimum safety factor that remains relatively high (typically 2 - 3, comparable to the predisruption safety factor), and a relatively low poloidal halo current. A 'type II' disruption is characterized by a minimum safety factor comparable to unity and a relatively high poloidal halo current. Model predictions for these two regimes are found to agree well with halo current measurements from vertical displacement event disruptions in DIII-D [T. S. Taylor, K. H. Burrell, D. R. Baker, G. L. Jackson, R. J. La Haye, M. A. Mahdavi, R. Prater, T. C. Simonen, and A. D. Turnbull, open-quotes Results from the DIII-D Scientific Research Program,close quotes in Proceedings of the 17th IAEA Fusion Energy Conference, Yokohama, 1998, to be published in

  20. Disruptive event analysis: volcanism and igneous intrusion

    International Nuclear Information System (INIS)

    Crowe, B.M.

    1980-08-01

    An evaluation is made of the disruptive effects of volcanic activity with respect to long term isolation of radioactive waste through deep geologic storage. Three major questions are considered. First, what is the range of disruption effects of a radioactive waste repository by volcanic activity. Second, is it possible, by selective siting of a repository, to reduce the risk of disruption by future volcanic activity. And third, can the probability of repository disruption by volcanic activity be quantified. The main variables involved in the evaluation of the consequences of repository disruption by volcanic activity are the geometry of the magma-repository intersection (partly controlled by depth of burial) and the nature of volcanism. Potential radionuclide dispersal by volcanic transport within the biosphere ranges in distance from several kilometers to global. Risk from the most catastrophic types of eruptions can be reduced by careful site selection to maximize lag time prior to the onset of activity. Certain areas or volcanic provinces within the western United States have been sites of significant volcanism and should be avoided as potential sites for a radioactive waste repository. Examples of projection of future sites of active volcanism are discussed for three areas of the western United States. Probability calculations require two types of data: a numerical rate or frequency of volcanic activity and a numerical evaluation of the areal extent of volcanic disruption for a designated region. The former is clearly beyond the current state of art in volcanology. The latter can be approximated with a reasonable degree of satisfaction. In this report, simplified probability calculations are attempted for areas of past volcanic activity

  1. Automated selective disruption of slow wave sleep.

    Science.gov (United States)

    Ooms, Sharon J; Zempel, John M; Holtzman, David M; Ju, Yo-El S

    2017-04-01

    Slow wave sleep (SWS) plays an important role in neurophysiologic restoration. Experimentally testing the effect of SWS disruption previously required highly time-intensive and subjective methods. Our goal was to develop an automated and objective protocol to reduce SWS without affecting sleep architecture. We developed a custom Matlab™ protocol to calculate electroencephalogram spectral power every 10s live during a polysomnogram, exclude artifact, and, if measurements met criteria for SWS, deliver increasingly louder tones through earphones. Middle-aged healthy volunteers (n=10) each underwent 2 polysomnograms, one with the SWS disruption protocol and one with sham condition. The SWS disruption protocol reduced SWS compared to sham condition, as measured by spectral power in the delta (0.5-4Hz) band, particularly in the 0.5-2Hz range (mean 20% decrease). A compensatory increase in the proportion of total spectral power in the theta (4-8Hz) and alpha (8-12Hz) bands was seen, but otherwise normal sleep features were preserved. N3 sleep decreased from 20±34 to 3±6min, otherwise there were no significant changes in total sleep time, sleep efficiency, or other macrostructural sleep characteristics. This novel SWS disruption protocol produces specific reductions in delta band power similar to existing methods, but has the advantage of being automated, such that SWS disruption can be performed easily in a highly standardized and operator-independent manner. This automated SWS disruption protocol effectively reduces SWS without impacting overall sleep architecture. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Disruptive Innovation by Emerging Multinational Latecomers

    DEFF Research Database (Denmark)

    Li, Peter Ping

    on disruptive innovation (DI) and the bottom of the pyramid (BOP) provides a great opportunity to shed light on the key issue. To take advantage of this “missed” opportunity, I integrate the two reframed constructs of DI and BOP and also develop a typology of four ideal-typical innovations toward a theory...... of latecomer innovation as a special DI by EMNE at BOP to provide insights into the mechanisms underlying the trajectories of catching up and leapfrogging. Built upon latecomer innovation, EMNEs at BOP can emerge as the most disruptive challengers to the MNE incumbents at TOP. The implications of reframed...

  3. Engineering aspects of disruption current decay

    International Nuclear Information System (INIS)

    Murray, J.G.

    1983-11-01

    Engineering features associated with the configuration of a tokamak can affect the amount of energy that produces melting and damage to the limiters or internal wall surfaces as the result of a major disruption. During the current decay period of a major thermal disruption, the energy that can damage a wall or limiter comes from the external magnetic field. By providing a good conducting torus near the plasma and increasing the plasma circuit resistance, this magnetic energy (transferred by way of the plasma circuit) can be minimized. This report addresses engineering design features to reduce the energy deposited on the inner torus surface that produces melting of the structures

  4. Development of disruption thermal analysis code DREAM

    International Nuclear Information System (INIS)

    Yamazaki, Seiichiro; Kobayahsi, Takeshi; Seki, Masahiro.

    1989-01-01

    When a plasma disruption takes place in a tokamak type fusion reactor, plasma facing componenets such as first wall and divertor/limiter are subjected to a intensse heat load in a short duration. At the surface of the wall, temperature rapidly rises, and melting and evaporation occurs. It causes reduction of wall thickness and crack initiation/propagation. As lifetime of the components is significantly affected by them, the transient analysis in consideration of phase changes and radiation heat loss in required in the design of these components. This paper describes the computer code DREAM, developed to perform the disruption thermal analysis, taking phase changes and radiation into account. (author)

  5. Energetics of LMFBR core disruptive accidents

    International Nuclear Information System (INIS)

    Marchaterre, J.F.

    1979-01-01

    In general, in the design of fast reactor systems, containment design margins are specified by investigating the response of the containment to core disruptive accidents. The results of these analyses are then translated into criteria which the designers must meet. Currently, uniform and agreed upon criteria are lacking, and in this time while they are being developed, the designer should be aware of the considerations which go into the particular criteria he must work with, and participate in their development. This paper gives an overview of the current state of the art in assessing core disruptive accidents and the design implications of this process. (orig.)

  6. Disruptive Technologies and Networking in Telecom Industries

    DEFF Research Database (Denmark)

    Madsen, Erik Strøjer; Hartington, Simon Preuthun

    2015-01-01

    This article discuss’ how economics of scale in supply and demand in the telecommunication industry has developed and how this has had great effect on the widespread usage and popularity of smartphones. By using this as a theoretical ground the paper looks into technical innovation...... in the telecommunication industry and finds significant similarities between the industry development and the literature on disruptive technology, which finds that incumbent companies are not able to react in a successful way when disruptions occur in their industry. By studying how the telecommunication industry...

  7. Disruptive technologies and networking in telecom industries

    DEFF Research Database (Denmark)

    Madsen, Erik Strøjer; Hartington, Simon

    This article discuss’ how economics of scale in supply and demand in the telecommunication industry has developed and how this has had great effect on the widespread usage and popularity of smart phones. By using this as a theoretical ground the paper looks into technical innovation...... in the telecommunication industry and finds significant similarities between the industry development and the literature on disruptive technology, which finds that incumbent companies are not able to react in a successful way when disruptions occur in their industry. By studying how the telecommunication industry...

  8. Disruptive School Peers and Student Outcomes

    DEFF Research Database (Denmark)

    Kristoffersen, Jannie H. Grøne; Krægpøth, Morten; Nielsen, Helena Skyt

    This paper estimates how peers’ achievement gains are affected by the presence of potentially disruptive and emotionally sensitive children in the school-cohort. We exploit that some children move between schools and thus generate variation in peer composition in the receiving school-cohort. We i...

  9. Naval sonar disrupts foraging in humpback whales

    NARCIS (Netherlands)

    Sivle, L.D.; Wensveen, P.J.; Kvadsheim, P.H.; Lam, F.P.A.; Visser, F.; Curé, C.; Harris, C.M.; Tyack, P.L.; Miller, P.J.O.

    2016-01-01

    Modern long-range naval sonars are a potential disturbance for marine mammals and can cause disruption of feeding in cetaceans. We examined the lunge-feeding behaviour of humpback whales Megaptera novaeangliae before, during and after controlled exposure experiments with naval sonar by use of

  10. Disruptive Innovation by Emerging Multinational Latecomers

    DEFF Research Database (Denmark)

    Li, Peter Ping

    on disruptive innovation (DI) and the bottom of the pyramid (BOP) provides a great opportunity to shed light on the key issue. To take advantage of this “missed” opportunity, I integrate the two reframed constructs of DI and BOP and also develop a typology of four ideal-typical innovations toward a theory...

  11. Biosensor discovery of thyroxine transport disrupting chemicals

    NARCIS (Netherlands)

    Marchesini, G.R.; Meimaridou, A.; Haasnoot, W.; Meulenberg, E.; Albertus, F.; Mizuguchi, M.; Takeuchi, M.; Irth, H.; Murk, A.J.

    2008-01-01

    Ubiquitous chemicals may interfere with the thyroid system that is essential in the development and physiology of vertebrates. We applied a surface plasmon resonance (SPR) biosensor-based screening method for the fast screening of chemicals with thyroxine (T4) transport disrupting activity. Two

  12. Gender, Career Disruption, and Academic Rewards.

    Science.gov (United States)

    McElrath, Karen

    1992-01-01

    A survey of 314 male and female faculty in criminology and sociology found that faculty women are more likely than men to leave academic positions, and women who interrupt careers commonly do so for a job-seeking spouse. Women experience significant losses in tenure and earnings as a result of career disruptions. (MSE)

  13. Is Online Learning a Disruptive Innovation?

    Science.gov (United States)

    Meyer, Katrina A.

    2011-01-01

    In their desire to plan for the future, planners must assess the role of both internal and external influences on the institution. What then should people make of the idea that technology is disruptive? This perception fuels the views of Barone and Hagner (2001), who claimed that technology would "transform" higher education; Duderstadt (2000),…

  14. Management of posterior urethral disruption injuries.

    Science.gov (United States)

    Myers, Jeremy B; McAninch, Jack W

    2009-03-01

    Posterior urethral disruption is a traumatic injury to the male urethra, which most often results from pelvic fracture. After trauma, the distraction defect between the two ends of the urethra often scars and becomes fibrotic, blocking the urethra and bladder emptying. Increasing evidence suggests that many posterior urethral disruptions occur at the junction between the membranous urethra and the bulbar urethra, which is distal to the rhabdosphincter. In the acute setting, when a posterior urethral disruption is suspected, retrograde urethrography should be performed. Posterior urethral disruptions can be managed acutely by realignment of the urethra over a urethral catheter or by placement of a suprapubic catheter for bladder drainage only. Once fibrosis has stabilized, the patient can undergo posterior urethroplasty. In most cases, this procedure can be performed via a perineal approach in a single-stage surgery. The results of this single-stage perineal urethroplasty are excellent, and a patent urethra can be re-established in the majority of men who undergo surgery.

  15. Histopathological and biochemical disrupting effects of Escravos ...

    African Journals Online (AJOL)

    user

    2014-02-27

    Feb 27, 2014 ... The aim of this study was to investigate the histological and biochemical disrupting effects of Escravos ... rupturing or leaking of production infrastructures that are described as, “very old and lack regular ... crude oil were measured in weight on an electronic weighing balance and given orally (oral gavage) ...

  16. Disrupted functional connectivity in adolescent obesity

    Directory of Open Access Journals (Sweden)

    Laura Moreno-Lopez

    2016-01-01

    Conclusions: These findings suggest that adolescent obesity is linked to disrupted functional connectivity in brain networks relevant to maintaining balance between reward, emotional memories and cognitive control. Our findings may contribute to reconceptualization of obesity as a multi-layered brain disorder leading to compromised motivation and control, and provide a biological account to target prevention strategies for adolescent obesity.

  17. Disrupting Educational Inequalities through Youth Digital Activism

    Science.gov (United States)

    Stornaiuolo, Amy; Thomas, Ebony Elizabeth

    2017-01-01

    This article reviews scholarship on youth and young adult activism in digital spaces, as young users of participatory media sites are engaging in political, civic, social, or cultural action and advocacy online to create social change. The authors argue that youth's digital activism serves as a central mechanism to disrupt inequality, and that…

  18. Natural and Professional Help during Marital Disruption.

    Science.gov (United States)

    Toro, Paul A.; Zax, Melvin

    Although few people bring their psychological problems to mental health professionals, research in the area of 'natural' help is rudimentary. To investigate the process and effectiveness of natural professional groups in helping individuals experiencing marital disruption, 42 helpers (14 mental health professionals, 14 divorce lawyers, and 14…

  19. Development of Disruptive Open Access Journals

    Science.gov (United States)

    Anderson, Terry; McConkey, Brigette

    2009-01-01

    Open access (OA) publication has emerged, with disruptive effects, as a major outlet for scholarly publication. OA publication is usually associated with on-line distribution and provides access to scholarly publications to anyone, anywhere--regardless of their ability to pay subscription fees or their association with an educational institution.…

  20. Dynamics and radiation from tidal disruption events

    NARCIS (Netherlands)

    Bonnerot, C.A.

    2017-01-01

    When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE). The stellar matter then fuels the compact object causing a bright flare that is a unique probe of the majority of galactic nuclei, otherwise quiescent. For

  1. Heavy Metals Acting as Endocrine Disrupters

    Directory of Open Access Journals (Sweden)

    Bogdan Georgescu

    2011-10-01

    Full Text Available Last years researches focused on several natural and synthetic compounds that may interfere with the major functionsof the endocrine system and were termed endocrine disrupters. Endocrine disrupters are defined as chemicalsubstances with either agonist or antagonist endocrine effects in human and animals. These effects may be achievedby interferences with the biosynthesis or activity of several endogenous hormones. Recently, it was demonstratedthat heavy metals such as cadmium (Cd, arsen (As, mercury (Hg, nickel (Ni, lead (Pb and zinc (Zn may exhibitendocrine-disrupting activity in animal experiments. Emerging evidence of the intimate mechanisms of action ofthese heavy metals is accumulating. It was revealed, for example, that the Zn atom from the Zn fingers of theestrogen receptor can be replaced by several heavy metal molecules such as copper, cobalt, Ni and Cd. By replacingthe Zn atom with Ni or copper, binding of the estrogen receptor to the DNA hormone responsive elements in the cellnucleus is prevented. In both males and females, low-level exposure to Cd interferes with the biological effects ofsteroid hormones in reproductive organs. Arsen has the property to bind to the glucocorticoid receptor thusdisturbing glucocorticoids biological effects. With regard to Hg, this may induce alterations in male and femalefertility, may affect the function of the hypothalamo-pituitary-thyroid axis or the hypothalamo-pituitary-adrenal axis,and disrupt biosynthesis of steroid hormones.

  2. Preliminary investigation into the possible endocrine disrupting ...

    African Journals Online (AJOL)

    JTEkanem

    Preliminary investigation into the possible endocrine disrupting activity of Bonny light crude oil contaminated - diet on ... rats (twenty male and twenty five females) were expose to Bonny –light crude oil contaminated diet at concentrations of 1%, 5% and 10% .... also being implicated in possessing antiestrogenic activity9.

  3. Time scales in tidal disruption events

    Directory of Open Access Journals (Sweden)

    Krolik J.

    2012-12-01

    Full Text Available We explore the temporal structure of tidal disruption events pointing out the corresponding transitions in the lightcurves of the thermal accretion disk and of the jet emerging from such events. The hydrodynamic time scale of the disrupted star is the minimal time scale of building up the accretion disk and the jet and it sets a limit on the rise time. This suggest that Swift J1644+57, that shows several flares with a rise time as short as a few hundred seconds could not have arisen from a tidal disruption of a main sequence star whose hydrodynamic time is a few hours. The disrupted object must have been a white dwarf. A second important time scale is the Eddington time in which the accretion rate changes form super to sub Eddington. It is possible that such a transition was observed in the light curve of Swift J2058+05. If correct this provides interesting constraints on the parameters of the system.

  4. The Relative Ineffectiveness of Criminal Network Disruption

    Science.gov (United States)

    Duijn, Paul A. C.; Kashirin, Victor; Sloot, Peter M. A.

    2014-01-01

    Researchers, policymakers and law enforcement agencies across the globe struggle to find effective strategies to control criminal networks. The effectiveness of disruption strategies is known to depend on both network topology and network resilience. However, as these criminal networks operate in secrecy, data-driven knowledge concerning the effectiveness of different criminal network disruption strategies is very limited. By combining computational modeling and social network analysis with unique criminal network intelligence data from the Dutch Police, we discovered, in contrast to common belief, that criminal networks might even become ‘stronger’, after targeted attacks. On the other hand increased efficiency within criminal networks decreases its internal security, thus offering opportunities for law enforcement agencies to target these networks more deliberately. Our results emphasize the importance of criminal network interventions at an early stage, before the network gets a chance to (re-)organize to maximum resilience. In the end disruption strategies force criminal networks to become more exposed, which causes successful network disruption to become a long-term effort. PMID:24577374

  5. Traffic disruption route Einstein near building 170

    CERN Multimedia

    A Lopez - TS/CE

    2005-01-01

    The TS/CE Group informs you that, for the duration of the work at Building 170, there may be some disruption to traffic on route Einstein in the vicinity of Building 170. The work is due to take place from the 14th to 18th February. For more information, please contact 165029. A. Lopez TS/CE

  6. 75 FR 69881 - Responding to Disruptive Patients

    Science.gov (United States)

    2010-11-16

    ... the health care setting, which opposes the use of punishment in the management of disruptive patients...: November 9, 2010. Robert C. McFetridge, Director of Regulation Policy and Management, Office of the General... definite period or until the conditions for removing conditions specified in the order are satisfied...

  7. Pesticides Provoke Endocrine Disruption A Review

    International Nuclear Information System (INIS)

    Aly, M.A.S.

    2006-01-01

    Increasing numbers of environmental chemicals,including pesticides, have the ability to produce endocrine disruption by various mechanisms. such substances may affect hormone secretion from an endocrine gland and may alter the rate of hormone elimination from the body. environmental chemicals may also disrupt regulatory feedback mechanisms that exist between two endocrine organs; or may interact with a hormone receptor either by mimicking or antagonizing the actions of the natural hormone. these chemicals are referred to endocrine disruptive chemicals (EDC's). EDC's act to alter the blood hormone levels or the subsequent action of hormones . the use of radioimmunoassay(RIA) constitutes a superior and unrivalled tool for the determination and quantification of hormones.the endocrine system participates in virtually all important functions of an organism, such as sexual differentiation before birth, sexual maturation during puberty, reproduction in adulthood, growth, metabolism, digestion, cardiovascular function and excretion. hormones are also implicated in the etiology of certain cancers of hormone- dependent tissues, such as those of the breast, uterus, and prostate gland. therefore, endocrine disruption can potentially produce widespread effects. scientists should not stick to the past belief which presumes that pesticides have limited effect on some hormones. A paradigm shift in which a wider vision of understanding of the wholesome complex effects of pesticides on the whole body rather than a narrow limited understanding should take place

  8. Perceptual consequences of disrupted auditory nerve activity.

    Science.gov (United States)

    Zeng, Fan-Gang; Kong, Ying-Yee; Michalewski, Henry J; Starr, Arnold

    2005-06-01

    Perceptual consequences of disrupted auditory nerve activity were systematically studied in 21 subjects who had been clinically diagnosed with auditory neuropathy (AN), a recently defined disorder characterized by normal outer hair cell function but disrupted auditory nerve function. Neurological and electrophysical evidence suggests that disrupted auditory nerve activity is due to desynchronized or reduced neural activity or both. Psychophysical measures showed that the disrupted neural activity has minimal effects on intensity-related perception, such as loudness discrimination, pitch discrimination at high frequencies, and sound localization using interaural level differences. In contrast, the disrupted neural activity significantly impairs timing related perception, such as pitch discrimination at low frequencies, temporal integration, gap detection, temporal modulation detection, backward and forward masking, signal detection in noise, binaural beats, and sound localization using interaural time differences. These perceptual consequences are the opposite of what is typically observed in cochlear-impaired subjects who have impaired intensity perception but relatively normal temporal processing after taking their impaired intensity perception into account. These differences in perceptual consequences between auditory neuropathy and cochlear damage suggest the use of different neural codes in auditory perception: a suboptimal spike count code for intensity processing, a synchronized spike code for temporal processing, and a duplex code for frequency processing. We also proposed two underlying physiological models based on desynchronized and reduced discharge in the auditory nerve to successfully account for the observed neurological and behavioral data. These methods and measures cannot differentiate between these two AN models, but future studies using electric stimulation of the auditory nerve via a cochlear implant might. These results not only show the unique

  9. The mass disruption of Jupiter Family comets

    Science.gov (United States)

    Belton, Michael J. S.

    2015-01-01

    I show that the size-distribution of small scattered-disk trans-neptunian objects when derived from the observed size-distribution of Jupiter Family comets (JFCs) and other observational constraints implies that a large percentage (94-97%) of newly arrived active comets within a range of 0.2-15.4 km effective radius must physically disrupt, i.e., macroscopically disintegrate, within their median dynamical lifetime. Additional observational constraints include the numbers of dormant and active nuclei in the near-Earth object (NEO) population and the slope of their size distributions. I show that the cumulative power-law slope (-2.86 to -3.15) of the scattered-disk TNO hot population between 0.2 and 15.4 km effective radius is only weakly dependent on the size-dependence of the otherwise unknown disruption mechanism. Evidently, as JFC nuclei from the scattered disk evolve into the inner Solar System only a fraction achieve dormancy while the vast majority of small nuclei (e.g., primarily those with effective radius <2 km) break-up. The percentage disruption rate appears to be comparable with that of the dynamically distinct Oort cloud and Halley type comets (Levison, H.F., Morbidelli, A., Dones, L., Jedicke, R., Wiegert, P.A., Bottke Jr., W.F. [2002]. Science 296, 2212-2215) suggesting that all types of comet nuclei may have similar structural characteristics even though they may have different source regions and thermal histories. The typical disruption rate for a 1 km radius active nucleus is ∼5 × 10-5 disruptions/year and the dormancy rate is typically 3 times less. We also estimate that average fragmentation rates range from 0.01 to 0.04 events/year/comet, somewhat above the lower limit of 0.01 events/year/comet observed by Chen and Jewitt (Chen, J., Jewitt, D.C. [1994]. Icarus 108, 265-271).

  10. Disrupt mig vel: Fire gode råd om disruption

    DEFF Research Database (Denmark)

    Rydén, Pernille; Ringberg, Torsten; Østergaard Jacobsen, Per

    2017-01-01

    Forandring. Ønsket om at være teknologisk foran, kommer ofte til at ske på bekostning af fokus på kundernes oplevelser. Lighedstegnet mellem disruption og ny teknologi er kun den halve sandhed.......Forandring. Ønsket om at være teknologisk foran, kommer ofte til at ske på bekostning af fokus på kundernes oplevelser. Lighedstegnet mellem disruption og ny teknologi er kun den halve sandhed....

  11. Longitudinal association between marital disruption and child BMI and obesity.

    Science.gov (United States)

    Arkes, Jeremy

    2012-08-01

    This research examines whether family disruptions (i.e., divorces and separation) contribute to children's weight problems. The sample consists of 7,299 observations for 2,333 children, aged 5-14, over the 1986-2006 period, from a US representative sample from the Child and Young Adult Survey accompanying the National Longitudinal Survey of Youth (NLSY). The study uses individual-fixed-effects models in a longitudinal framework to compare children's BMI and weight problems before and after a disruption. Furthermore, besides doing a before-after comparison for children, the study also estimates the effects at various periods relative to the disruption in order to examine whether children are affected before the disruption and whether any effects change as time passes from the disruption, as some effects may be temporary or slow to develop. Despite having a larger sample than the previous studies, the results provide no evidence that, on average, children's BMI and BMI percentile scores (measured with continuous outcomes) are affected before the disruption, after the disruption, and as time passes from the disruption, relative to a baseline period a few years before the disruption. However, children experiencing a family disruption do have an increased risk of obesity (having a BMI percentile score of 95 or higher) in the two years leading up to the disruption as well as after the disruption, and as time passes from the disruption.

  12. Academic Publishing, Internet Technology, and Disruptive Innovation

    Directory of Open Access Journals (Sweden)

    Haven Allahar

    2017-11-01

    Full Text Available After 350 years of operation, the academic journal publishing industry is imbalanced and in flux as a result of the impacts of Internet technology, which has led, over the past 20 years, to the rise of open access publishing. The introduction of open access journals, in the opinion of many researchers, is considered to be a case of disruptive innovation that is revolutionizing the industry. This article analyzes the traditional journal publishing system, the recent open access models of journal publishing as an evolving phenomenon, the nature and extent of open access as a disruptive innovation, and the implications for key stakeholders. The major finding is that open access publishing has gained traction because technology has contributed to lower publication costs, easier access to research articles, and speedier publishing processes. However, the threat posed by open access has not significantly impacted traditional publishers because of strategies employed by the major publishers and slow adoption of open access by some researchers.

  13. Thyroid effects of endocrine disrupting chemicals

    DEFF Research Database (Denmark)

    Boas, Malene; Feldt-Rasmussen, Ulla; Main, Katharina M

    2012-01-01

    In recent years, many studies of thyroid-disrupting effects of environmental chemicals have been published. Of special concern is the exposure of pregnant women and infants, as thyroid disruption of the developing organism may have deleterious effects on neurological outcome. Chemicals may exert...... thyroid effects through a variety of mechanisms of action, and some animal experiments and in vitro studies have focused on elucidating the mode of action of specific chemical compounds. Long-term human studies on effects of environmental chemicals on thyroid related outcomes such as growth...... and development are still lacking. The human exposure scenario with life long exposure to a vast mixture of chemicals in low doses and the large physiological variation in thyroid hormone levels between individuals render human studies very difficult. However, there is now reasonably firm evidence that PCBs have...

  14. Manufacturing doubt about endocrine disrupter science

    DEFF Research Database (Denmark)

    Bergman, Åke; Becher, Georg; Blumberg, Bruce

    2015-01-01

    as flawed. We show that Lamb et al. misuse conceptual frameworks for assessing causality, especially the Bradford-Hill criteria, by ignoring the fundamental problems that exist with inferring causality from empirical observations. We conclude that Lamb et al.'s attempt of deconstructing the UNEP/WHO (2013......We present a detailed response to the critique of "State of the Science of Endocrine Disrupting Chemicals 2012" (UNEP/WHO, 2013) by financial stakeholders, authored by Lamb et al. (2014). Lamb et al.'s claim that UNEP/WHO (2013) does not provide a balanced perspective on endocrine disruption...... is based on incomplete and misleading quoting of the report through omission of qualifying statements and inaccurate description of study objectives, results and conclusions. Lamb et al. define extremely narrow standards for synthesizing evidence which are then used to dismiss the UNEP/WHO 2013 report...

  15. Electromagnetic safety analysis during major disruption

    International Nuclear Information System (INIS)

    Gao Chunming; Wang Yafei; Chen Zhi; Feng Kaiming

    2006-01-01

    The electromagnetic safety analysis during major disruption is important for safety analysis of the CH HCSB TBM. In this paper, using finite element method, the electromagnetic safety analysis of the CH HCSB TBM is carried out in consideration of major disruption. First, the finite element models of the CH HCSB TBM and its sub-module are established; second, the distributions of the induced eddy currents and electromagnetic forces on the whole CH HCSB TBM module and its sub-module are calculated; third, the torquemoment on whole CH HCSB TBM module and its sub-module are calculated from the distributions of the electromagnetic forces. Comparing the maximum allowable values of the parameters of the materials with the calculated data, the electromagnetic safety of the CH HCSB TBM is investigated. (authors)

  16. Neural net prediction of tokamak plasma disruptions

    International Nuclear Information System (INIS)

    Hernandez, J.V.; Lin, Z.; Horton, W.; McCool, S.C.

    1994-10-01

    The computation based on neural net algorithms in predicting minor and major disruptions in TEXT tokamak discharges has been performed. Future values of the fluctuating magnetic signal are predicted based on L past values of the magnetic fluctuation signal, measured by a single Mirnov coil. The time step used (= 0.04ms) corresponds to the experimental data sampling rate. Two kinds of approaches are adopted for the task, the contiguous future prediction and the multi-timescale prediction. Results are shown for comparison. Both networks are trained through the back-propagation algorithm with inertial terms. The degree of this success indicates that the magnetic fluctuations associated with tokamak disruptions may be characterized by a relatively low-dimensional dynamical system

  17. Endocrine-disrupting chemicals and skin manifestations.

    Science.gov (United States)

    Ju, Qiang; Zouboulis, Christos C

    2016-09-01

    Endocrine-disrupting chemicals (EDCs) are exogenous compounds that have the ability to disrupt the production and actions of hormones through direct or indirect interaction with hormone receptors, thus acting as agonists or antagonists. Human health is affected after either individual occupation or dietary and environmental exposure to EDCs. On the other hand, skin is one of the largest organs of the body and its main function is protection from noxious substances. EDCs perturb the endocrine system, and they are also carcinogenic, immunotoxic, and hepatotoxic to human skin. In addition, their effects on keratinocytes, melanocytes, sebocytes, inflammatory and immunological cells, and skin stem cells produce inflammatory and allergic skin diseases, chloracne, disorders of skin pigmentation, skin cancer, and skin aging. Mechanisms, which EDCs use to induce these skin disorders are complicated, and involve the interference of endogenous hormones and most importantly the activation of the aryl hydrocarbon receptor signal pathway. Further studies on EDCs and skin diseases are necessary to elucidate these mechanisms.

  18. CUMULATIVE DEVELOPMENTAL EFFECTS OF ENDOCRINE DISRUPTERS: SYNERGY OR ADDITIVITY?

    Science.gov (United States)

    Exposure to chemicals with hormonal activity during critical developmental periods can disrupt reproductive function and development. Within the last decade, several classes of pesticides and toxic substances have been shown to disrupt differentiation of the male rat reproductive...

  19. Conversion of homothallic yeast to heterothallism through to gene disruption

    CSIR Research Space (South Africa)

    Van Zyl, WH

    1993-04-01

    Full Text Available A simple method was developed for the conversion of homothallic Saccharomyces cerevisiae yeast strains to heterothallism through HO gene disruption. An integrative ho=neo disrupted allele was constructed by cloning a dominant selectable marker...

  20. Conversion of homothallic yeast to heterothallism trough HO gene disruption

    CSIR Research Space (South Africa)

    Van Zyl, WH

    1993-04-01

    Full Text Available A simple method was developed for the conversion of homothallic Saccharomyces cerevisiae yeaststrains to heterothallism through HO gene disruption. An integrative ho:: neo disrupted allele was constructed by cloning a dominant selectable marker...

  1. Capture of Small Bodies After Tidal Disruption

    Science.gov (United States)

    Ershova, A.; Medvedev, Yu.

    2017-09-01

    The subject of the current work is the phisical and dynamical evolution of the small comets group formed by tidal disruption of the protocomet while passing near the large body (Sun, Jupiter). The equations of motion were integrated numericaly. In case of the Sun the evolution of the sun-grazing orbits were discussed and the typical lifetime of such comets was estimated. Nongravitational acceleration and the size reduction of fragments due to sublimation were taking into account using the Marsden formula.

  2. Five disruptive technology directions for 5G

    DEFF Research Database (Denmark)

    Boccardi, Federico; W. Heath Jr., Robert; Lozano, Angel

    2014-01-01

    New research directions will lead to fundamental changes in the design of future fifth generation (5G) cellular networks. This article describes five technologies that could lead to both architectural and component disruptive design changes: device-centric architectures, millimeter wave, massive...... MIMO, smarter devices, and native support for machine-to-machine communications. The key ideas for each technology are described, along with their potential impact on 5G and the research challenges that remain....

  3. National Defense Industrial Association Disruptive Technologies Conference

    Science.gov (United States)

    2009-10-14

    Algorithms, MEMS • Nano ; Meta; & New Materials • Cognitive Computing • Bio-Revolution NDIA Disruptive Technologies 10/16/2009 Page-8 Forces of Change...DISTRIBUTE 2 1 st Cen t u r y St r a t eg ic Tec h n o l o g y Vec t o r s Defense Science Board 2006 Summer Study August 18, 2006 (Final) NDIA

  4. Disruptive Innovation in Chinese and Indian Businesses

    DEFF Research Database (Denmark)

    With the rapid development of China and India as new economic powers in global competition, an obvious question is whether these emerging economies are great opportunities or threats. Whilst answers are bound to differ depending on one's perspective, it is increasingly clear that more local firms...... sustainable. This unique book will be valuable to both scholars and practitioners interested in disruptive innovation and those working in the fields of Asian studies, international business, economics and globalization...

  5. Disruption effects on the beam size measurement

    Energy Technology Data Exchange (ETDEWEB)

    Raimondi, P.; Decker, F.J.; Chen, P.

    1995-06-01

    At the SLC Final Focus with higher currents and smaller beam sizes, the disruption parameter D{sub y} is close to one and so the pinch effect should produce a luminosity enhancement. Since a flat beam-beam function is fit to deflection scan data to measure the beam size, disruption can affect the measurement. Here the authors discuss the quantitative effects of disruption for typical SLC beam parameters. With 3.5 10{sup 10} particles per pulse, bunch length of 0.8 mm and beam sizes of 2.1 {mu}m horizontally and 0.55 {mu}m vertically, the measured vertical size can be as much as 25% bigger than the real one. Furthermore during the collision the spot size actually decrease, producing an enhancement factor H{sub D} of about 1.25. This would yield to a true luminosity which is 1.6 times that which is estimated from the beam-beam deflection fit.

  6. Disruptive Innovation Can Prevent the Next Pandemic.

    Science.gov (United States)

    Shaikh, Affan T; Ferland, Lisa; Hood-Cree, Robert; Shaffer, Loren; McNabb, Scott J N

    2015-01-01

    Public health surveillance (PHS) is at a tipping point, where the application of novel processes, technologies, and tools promise to vastly improve efficiency and effectiveness. Yet twentieth century, entrenched ideology and lack of training results in slow uptake and resistance to change. The term disruptive innovation - used to describe advances in technology and processes that change existing markets - is useful to describe the transformation of PHS. Past disruptive innovations used in PHS, such as distance learning, the smart phone, and field-based laboratory testing have outpaced older services, practices, and technologies used in the traditional classroom, governmental offices, and personal communication, respectively. Arguably, the greatest of these is the Internet - an infrastructural innovation that continues to enable exponential benefits in seemingly limitless ways. Considering the Global Health Security Agenda and facing emerging and reemerging infectious disease threats, evolving environmental and behavioral risks, and ever changing epidemiologic trends, PHS must transform. Embracing disruptive innovation in the structures and processes of PHS can be unpredictable. However, it is necessary to strengthen and unlock the potential to prevent, detect, and respond.

  7. Spin Dependence in Tidal Disruption Events

    Science.gov (United States)

    Kesden, Michael; Stone, Nicholas; van Velzen, Sjoert

    2018-01-01

    A supermassive black hole (SBH) can tidally disrupt stars when its tidal field overwhelms the stars’ self-gravity. The stellar debris produced in such tidal disruption events (TDEs) evolves into tidal streams that can self-intersect. These inelastic stream collisions dissipate orbital energy, both circularizing the tidal stream and contributing to the emission observed during the TDE. Once circularized into a disk, the stellar debris can be viscously accreted by the SBH powering additional luminous emission. We explore how SBH spin can affect the tidal disruption process. Tidal forces are spin dependent, as is the minimum orbital angular momentum below which stars are directly captured by the SBH. This implies that the TDE rate will be spin dependent, particularly for more massive SBHs for which relativistic effects are more significant. SBH spin also affects TDE light curves through the initial debris orbits, the nature of the stream collisions, the viscous evolution of the accretion disk, and the possibility of launching jets. We explore the spin dependence of these phenomena to identify promising signatures for upcoming surveys expected to discover hundreds of TDE candidates in the next decade.

  8. Natural Hazards and Supply Chain Disruptions

    Science.gov (United States)

    Haraguchi, M.

    2016-12-01

    Natural hazards distress the global economy through disruptions in supply chain networks. Moreover, despite increasing investment to infrastructure for disaster risk management, economic damages and losses caused by natural hazards are increasing. Manufacturing companies today have reduced inventories and streamlined logistics in order to maximize economic competitiveness. As a result, today's supply chains are profoundly susceptible to systemic risks, which are the risk of collapse of an entire network caused by a few node of the network. For instance, the prolonged floods in Thailand in 2011 caused supply chain disruptions in their primary industries, i.e. electronic and automotive industries, harming not only the Thai economy but also the global economy. Similar problems occurred after the Great East Japan Earthquake and Tsunami in 2011, the Mississippi River floods and droughts during 2011 - 2013, and the Earthquake in Kumamoto Japan in 2016. This study attempts to discover what kind of effective measures are available for private companies to manage supply chain disruptions caused by floods. It also proposes a method to estimate potential risks using a Bayesian network. The study uses a Bayesian network to create synthetic networks that include variables associated with the magnitude and duration of floods, major components of supply chains such as logistics, multiple layers of suppliers, warehouses, and consumer markets. Considering situations across different times, our study shows desirable data requirements for the analysis and effective measures to improve Value at Risk (VaR) for private enterprises and supply chains.

  9. Disruptive Innovation Can Prevent the Next Pandemic

    Directory of Open Access Journals (Sweden)

    Affan eShaikh

    2015-09-01

    Full Text Available Public health surveillance (PHS is at a tipping point, where the application of novel processes, technologies, and tools promise to vastly improve efficiency and effectiveness. Yet 20th-century, entrenched ideology and lack of training results in slow uptake and resistance to change. The term disruptive innovation – used to describe advances in technology and processes that change existing markets, is useful to describe the transformation of PHS. Past disruptive innovations used in PHS, such as distance learning, the smart phone, and field-based laboratory testing have outpaced older services, practices, and technologies used in the traditional classroom, governmental offices, and personal communication, respectively. Arguably, the greatest of these is the Internet – an infrastructural innovation that continues to enable exponential benefits in seemingly limitless ways. Considering the Global Health Security Agenda and facing emerging and reemerging infectious disease threats, evolving environmental and behavioral risks, and ever changing epidemiologic trends, PHS must transform. Embracing disruptive innovation in the structures and processes of PHS can be unpredictable. However it is necessary to strengthen and unlock the potential to prevent, detect, and respond.

  10. Risk Evaluation of Endocrine-Disrupting Chemicals

    Directory of Open Access Journals (Sweden)

    Laura Gioiosa

    2015-10-01

    Full Text Available We review here our studies on early exposure to low doses of the estrogenic endocrine-disrupting chemical bisphenol A (BPA on behavior and metabolism in CD-1 mice. Mice were exposed in utero from gestation day (GD 11 to delivery (prenatal exposure or via maternal milk from birth to postnatal day 7 (postnatal exposure to 10 µg/kg body weight/d of BPA or no BPA (controls. Bisphenol A exposure resulted in long-term disruption of sexually dimorphic behaviors. Females exposed to BPA pre- and postnatally showed increased anxiety and behavioral profiles similar to control males. We also evaluated metabolic effects in prenatally exposed adult male offspring of dams fed (from GD 9 to 18 with BPA at doses ranging from 5 to 50 000 µg/kg/d. The males showed an age-related significant change in a number of metabolic indexes ranging from food intake to glucose regulation at BPA doses below the no observed adverse effect level (5000 µg/kg/d. Consistent with prior findings, low but not high BPA doses produced significant effects for many outcomes. These findings provide further evidence of the potential risks that developmental exposure to low doses of the endocrine disrupter BPA may pose to human health, with fetuses and infants being highly vulnerable.

  11. Influence of Dynamic Capabilities in Creating Disruptive Innovation

    OpenAIRE

    Čiutienė, Rūta; Thattakath, Emil William

    2015-01-01

    The aim of this paper is to demonstrate the influence of Dynamic Capabilities in creating Disruptive Innovation. For doing so the concepts of Dynamic Capabilities and Disruptive Innovation are reviewed. The criteria of an innovation named Disruptive Innovation are obtained by comparative study between the various innovation types. To demonstrate the role of Dynamic Capabilities in creating Disruptive Innovation, the Innovation Lifecycle is demonstrated with respect to Dynamic Capabilities. Th...

  12. Antecedents and implications of disruptive innovation: Evidence from China

    OpenAIRE

    Wan, Feng; Williamson, Peter; Yin, Eden

    2015-01-01

    A growing recognition of the importance of disruptive innovation has led researchers to examine the question of how disruptive innovation comes about and to what extent it reflects "discovery" versus "creation" of opportunities. Earlier research has focused on the organisational preconditions for disruptive innovation to arise. Much less attention has been paid to the role of innovation processes, including their goals and design, in promoting disruptive innovation. In this paper we aim to be...

  13. Cost Sharing in the Prevention of Supply Chain Disruption

    OpenAIRE

    Wen Wang; Kelei Xue; Xiaochen Sun

    2017-01-01

    We examine the influence of cost-sharing mechanism on the disruption prevention investment in a supply chain with unreliable suppliers. When a supply chain faces considerable loss following a disruption, supply chain members are motivated toward investing in manners that reduce their disruption probability. In improving supply chain reliability, the cost-sharing mechanism must be set appropriately to realize the efficiency of the disruption prevention investment. In a supply chain where the f...

  14. Disruptive Behaviour of Students in Primary Education and Emotional Intelligence

    Science.gov (United States)

    Esturgo-Deu, M. Estrella; Sala-Roca, Josefina

    2010-01-01

    This study analyses the relation between disruptive behaviours and the emotional abilities of children in primary education. To do this, disruptive behaviour and emotional abilities were evaluated in 1422 pupils aged between 6 and 12 years of age at 11 education centres using EQIjv. No relation was found between disruptive behaviours and age, but…

  15. Practice Oriented Algorithmic Disruption Management in Passenger Railways

    NARCIS (Netherlands)

    J.C. Wagenaar (Joris)

    2016-01-01

    markdownabstractHow to deal with a disruption is a question railway companies face on a daily basis. This thesis focusses on the subject how to handle a disruption such that the passenger service is upheld as much as possible. The current mathematical models for disruption management can not yet be

  16. Feature extraction for improved disruption prediction analysis at JET

    International Nuclear Information System (INIS)

    Ratta, G. A.; Vega, J.; Murari, A.; Johnson, M.

    2008-01-01

    Disruptions are major instabilities and remain one of the main problems in tokomaks. Using Joint European Torus database, a disruption predictor is developed by computational methods including supervised learning techniques. The main objectives of the work are to develop accurate automatic classifiers, to test their performances, and to determine how much in advance of the disruption they can operate with acceptable reliability.

  17. Science and policy on endocrine disrupters must not be mixed

    DEFF Research Database (Denmark)

    Bergman, Åke; Andersson, Anna-Maria; Becher, Georg

    2013-01-01

    The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about...... of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU....

  18. Disruption of Four Kinesin Genes in Dictyostelium

    Directory of Open Access Journals (Sweden)

    Soga Ikko

    2008-04-01

    Full Text Available Abstract Background Kinesin and dynein are the two families of microtubule-based motors that drive much of the intracellular movements in eukaryotic cells. Using a gene knockout strategy, we address here the individual function(s of four of the 13 kinesin proteins in Dictyostelium. The goal of our ongoing project is to establish a minimal motility proteome for this basal eukaryote, enabling us to contrast motor functions here with the often far more elaborate motor families in the metazoans. Results We performed individual disruptions of the kinesin genes, kif4, kif8, kif10, and kif11. None of the motors encoded by these genes are essential for development or viability of Dictyostelium. Removal of Kif4 (kinesin-7; CENP-E family significantly impairs the rate of cell growth and, when combined with a previously characterized dynein inhibition, results in dramatic defects in mitotic spindle assembly. Kif8 (kinesin-4; chromokinesin family and Kif10 (kinesin-8; Kip3 family appear to cooperate with dynein to organize the interphase radial microtubule array. Conclusion The results reported here extend the number of kinesin gene disruptions in Dictyostelium, to now total 10, among the 13 isoforms. None of these motors, individually, are required for short-term viability. In contrast, homologs of at least six of the 10 kinesins are considered essential in humans. Our work underscores the functional redundancy of motor isoforms in basal organisms while highlighting motor specificity in more complex metazoans. Since motor disruption in Dictyostelium can readily be combined with other motility insults and stresses, this organism offers an excellent system to investigate functional interactions among the kinesin motor family.

  19. Pheromone disruption of Argentine ant trail integrity

    Science.gov (United States)

    Suckling, D.M.; Peck, R.W.; Manning, L.M.; Stringer, L.D.; Cappadonna, J.; El-Sayed, A. M.

    2008-01-01

    Disruption of Argentine ant trail following and reduced ability to forage (measured by bait location success) was achieved after presentation of an oversupply of trail pheromone, (Z)-9-hexadecenal. Experiments tested single pheromone point sources and dispersion of a formulation in small field plots. Ant walking behavior was recorded and digitized by using video tracking, before and after presentation of trail pheromone. Ants showed changes in three parameters within seconds of treatment: (1) Ants on trails normally showed a unimodal frequency distribution of walking track angles, but this pattern disappeared after presentation of the trail pheromone; (2) ants showed initial high trail integrity on a range of untreated substrates from painted walls to wooden or concrete floors, but this was significantly reduced following presentation of a point source of pheromone; (3) the number of ants in the pheromone-treated area increased over time, as recruitment apparently exceeded departures. To test trail disruption in small outdoor plots, the trail pheromone was formulated with carnuba wax-coated quartz laboratory sand (1 g quartz sand/0.2 g wax/1 mg pheromone). The pheromone formulation, with a half-life of 30 h, was applied by rotary spreader at four rates (0, 2.5, 7.5, and 25 mg pheromone/m2) to 1- and 4-m2 plots in Volcanoes National Park, Hawaii. Ant counts at bait cards in treated plots were significantly reduced compared to controls on the day of treatment, and there was a significant reduction in ant foraging for 2 days. These results show that trail pheromone disruption of Argentine ants is possible, but a much more durable formulation is needed before nest-level impacts can be expected. ?? 2008 Springer Science+Business Media, LLC.

  20. Laser Microbial Killing and Biofilm Disruption

    Science.gov (United States)

    Krespi, Yosef P.; Kizhner, Victor

    2009-06-01

    Objectives: To analyze the ability of NIR lasers to reduce bacterial load and demonstrate the capability of fiber-based Q-switched Nd:YAG laser disrupting biofilm. Study Design: NIR diode laser was tested in vitro and in vivo using pathogenic microorganisms (S. aureus, S. pneumoniae, P. aeruginosa). In addition biofilms were grown from clinical Pseudomonas isolates and placed in culture plates, screws, tympanostomy tubes and PET sutures. Methods: In the animal experiments acute rhinosinusitis model was created by packing the rabbit nose with bacteria soaked solution. The nasal pack was removed in two days and nose was exposed to laser irradiation. A 940 nm diode laser with fiber diffuser was used. Nasal cultures were obtained before and after the laser treatments. Animals were sacrificed fifteen days following laser treatment and bacteriologic/histologic results analyzed. Q-switched Nd:YAG laser generated shockwave pulses were delivered on biofilm using special probes over culture plates, screws, tubes, and PET sutures for the biofilm experiments. Results: Average of two log bacteria reduction was achieved with NIR laser compared to controls. Histologic studies demonstrated preservation of tissue integrity without significant damage to mucosa. Biofilms were imaged before, during and after treatment using a confocal microscope. During laser-generated shockwave application, biofilm was initially seen to oscillate and eventually break off. Large and small pieces of biofilm were totally and instantly removed from the surface to which they were attached in seconds. Conclusions: Significant bacterial reduction was achieved with NIR laser therapy in this experimental in vitro and animal study. In addition we disrupted Pseudomonas aeruginosa biofilms using Q-switched Nd:YAG laser and special probes generating plasma and shockwave. This new and innovative method of bacteria killing and biofilm disruption without injuring host tissue may have clinical application in the

  1. Physics and observations of tidal disruption events

    Science.gov (United States)

    Mangalam, Arun; Mageshwaran, Tamilan

    2018-04-01

    We describe a model of tidal disruption events (TDEs) with input physical parameters that include the black hole (BH) mass M•, the specific orbital energy E, the angular momentum J, the star mass M⊙ and radius R⊙. We calculate the rise time of the TDEs, the peak bolometric luminosity in terms of these physical parameters and a typical light curve of TDEs for various All Sky Survey (ASS) and Deep Sky Survey (DSS) missions. We then derive the expected detection rates and discuss the follow up of TDEs through observations in various spectral bands from X-rays to radio wavelengths.

  2. Electrical disruption in toroidal plasma of hydrogen

    International Nuclear Information System (INIS)

    Roberto, M.; Silva, C.A.B.; Goes, L.C.S.; Sudano, J.P.

    1991-01-01

    The initial phase of ionization of a toroidal plasma produced in hydrogen was investigated using zero-dimensional model. The model describes the temporal evolution of plasma by spatial medium of particle density and temperature, on whole plasma volume. The energy and particle (electrons and ions) balance equations are considered. The electron loss is due to ambipolar diffusion in the presence of magnetic field. The electron energy loss involves ionization, Coulomb interaction and diffusion. The ohmic heating converter gives the initial voltage necessary to disruption. (M.C.K.)

  3. Manuel′s asteroid disruption technique

    Directory of Open Access Journals (Sweden)

    Manuel John

    2015-01-01

    Full Text Available A seventy-year-old male presented with dense asteroid hyalosis in both eyes. He had undergone cataract extraction in one eye 3 years ago, and the other eye had immature cataract. Both the autorefractor and dilated streak retinoscopy did not give readings and subjective visual improvement could not be achieved. Immediately following YAG posterior capsulotomy and anterior vitreous asteroid disruption, the vision improved to 20/20 with recordable auto refractor and streak retinoscopy values. Our initial experience indicates that the treatment is simple, safe and effective but needs controlled and prospective studies to confirm its long-term safety.

  4. Disruptive Innovation in Air Measurement Technology: Reality ...

    Science.gov (United States)

    This presentation is a big picture overview on the changing state of air measurement technology in the world, with a focus on the introduction of low-cost sensors into the market place. The presentation discusses how these new technologies may be a case study in disruptive innovation for the air pollution measurement field. The intended audience is primarily those with experience in air pollution measurement methods, but much of the talk is accessible to the general public. This is a keynote presentation on emerging air monitoring technology, to be provided at the AWMA measurements conference in March, 2016.

  5. Disruption management in the airline industry

    OpenAIRE

    Mariani, Carlotta

    2015-01-01

    The first point of the study purpose is taken into account in the second and third chapter of this work. It helps to create the ground of the successive argument and it also shows the main problem that could generate a delays or a disruptions in the airline industry. We know that the structure of airlines is divided into various phase and they are strategic, tactical and operational phases. part of the strategic phase are Routes, Type of aircraft (size), Price / policy, Out-sou...

  6. Multimedia data mining and analytics disruptive innovation

    CERN Document Server

    Baughman, Aaron; Pan, Jia-Yu; Petrushin, Valery A

    2015-01-01

    This authoritative text/reference provides fresh insights into the cutting edge of multimedia data mining, reflecting how the research focus has shifted towards networked social communities, mobile devices and sensors. Presenting a detailed exploration into the progression of the field, the book describes how the history of multimedia data processing can be viewed as a sequence of disruptive innovations. Across the chapters, the discussion covers the practical frameworks, libraries, and open source software that enable the development of ground-breaking research into practical applications.

  7. The mass disruption of Oort cloud comets.

    Science.gov (United States)

    Levison, Harold F; Morbidelli, Alessandro; Dones, Luke; Jedicke, Robert; Wiegert, Paul A; Bottke, William F

    2002-06-21

    We have calculated the number of dormant, nearly isotropic Oort cloud comets in the solar system by (i) combining orbital distribution models with statistical models of dormant comet discoveries by well-defined surveys and (ii) comparing the model results to observations of a population of dormant comets. Dynamical models that assume that comets are not destroyed predict that we should have discovered approximately 100 times more dormant nearly isotropic comets than are actually seen. Thus, as comets evolve inward from the Oort cloud, the majority of them must physically disrupt.

  8. Features, Events, and Processes: Disruptive Events

    Energy Technology Data Exchange (ETDEWEB)

    P. Sanchez

    2004-11-08

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA).

  9. Disruptive mood dysregulation disorder: current insights

    Directory of Open Access Journals (Sweden)

    Baweja R

    2016-08-01

    Full Text Available Raman Baweja, Susan D Mayes, Usman Hameed, James G Waxmonsky Department of Psychiatry, Penn State University College of Medicine, Hershey, PA, USA Abstract: Disruptive mood dysregulation disorder (DMDD was introduced as a new diagnostic entity under the category of depressive disorders in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5. It was included in DSM-5 primarily to address concerns about the misdiagnosis and consequent overtreatment of bipolar disorder in children and adolescents. DMDD does provide a home for a large percentage of referred children with severe persistent irritability that did not fit well into any DSM, Fourth Edition (DSM-IV diagnostic category. However, it has been a controversial addition to the DSM-5 due to lack of published validity studies, leading to questions about its validity as a distinct disorder. In this article, the authors discuss the diagnostic criteria, assessment, epidemiology, criticism of the diagnosis, and pathophysiology, as well as treatment and future directions for DMDD. They also review the literature on severe mood dysregulation, as described by the National Institute of Mental Health, as the scientific support for DMDD is based primarily on studies of severe mood dysregulation. Keywords: disruptive mood dysregulation disorder, persistent irritability, temper outbursts 

  10. Smog induces oxidative stress and microbiota disruption

    Directory of Open Access Journals (Sweden)

    Tit-Yee Wong

    2017-04-01

    Full Text Available Smog is created through the interactions between pollutants in the air, fog, and sunlight. Air pollutants, such as carbon monoxide, heavy metals, nitrogen oxides, ozone, sulfur dioxide, volatile organic vapors, and particulate matters, can induce oxidative stress in human directly or indirectly through the formation of reactive oxygen species. The outermost boundary of human skin and mucous layers are covered by a complex network of human-associated microbes. The relation between these microbial communities and their human host are mostly mutualistic. These microbes not only provide nutrients, vitamins, and protection against other pathogens, they also influence human's physical, immunological, nutritional, and mental developments. Elements in smog can induce oxidative stress to these microbes, leading to community collapse. Disruption of these mutualistic microbiota may introduce unexpected health risks, especially among the newborns and young children. Besides reducing the burning of fossil fuels as the ultimate solution of smog formation, advanced methods by using various physical, chemical, and biological means to reduce sulfur and nitrogen contains in fossil fuels could lower smog formation. Additionally, information on microbiota disruption, based on functional genomics, culturomics, and general ecological principles, should be included in the risk assessment of prolonged smog exposure to the health of human populations.

  11. Features, Events, and Processes: Disruptive Events

    International Nuclear Information System (INIS)

    P. Sanchez

    2004-01-01

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA)

  12. Modeling Steroidogenesis Disruption Using High-Throughput ...

    Science.gov (United States)

    Environmental chemicals can elicit endocrine disruption by altering steroid hormone biosynthesis and metabolism (steroidogenesis) causing adverse reproductive and developmental effects. Historically, a lack of assays resulted in few chemicals having been evaluated for effects on steroidogenesis. The steroidogenic pathway is a series of hydroxylation and dehydrogenation steps carried out by CYP450 and hydroxysteroid dehydrogenase enzymes, yet the only enzyme in the pathway for which a high-throughput screening (HTS) assay has been developed is aromatase (CYP19A1), responsible for the aromatization of androgens to estrogens. Recently, the ToxCast HTS program adapted the OECD validated H295R steroidogenesis assay using human adrenocortical carcinoma cells into a high-throughput model to quantitatively assess the concentration-dependent (0.003-100 µM) effects of chemicals on 10 steroid hormones including progestagens, androgens, estrogens and glucocorticoids. These results, in combination with two CYP19A1 inhibition assays, comprise a large dataset amenable to clustering approaches supporting the identification and characterization of putative mechanisms of action (pMOA) for steroidogenesis disruption. In total, 514 chemicals were tested in all CYP19A1 and steroidogenesis assays. 216 chemicals were identified as CYP19A1 inhibitors in at least one CYP19A1 assay. 208 of these chemicals also altered hormone levels in the H295R assay, suggesting 96% sensitivity in the

  13. Smog induces oxidative stress and microbiota disruption.

    Science.gov (United States)

    Wong, Tit-Yee

    2017-04-01

    Smog is created through the interactions between pollutants in the air, fog, and sunlight. Air pollutants, such as carbon monoxide, heavy metals, nitrogen oxides, ozone, sulfur dioxide, volatile organic vapors, and particulate matters, can induce oxidative stress in human directly or indirectly through the formation of reactive oxygen species. The outermost boundary of human skin and mucous layers are covered by a complex network of human-associated microbes. The relation between these microbial communities and their human host are mostly mutualistic. These microbes not only provide nutrients, vitamins, and protection against other pathogens, they also influence human's physical, immunological, nutritional, and mental developments. Elements in smog can induce oxidative stress to these microbes, leading to community collapse. Disruption of these mutualistic microbiota may introduce unexpected health risks, especially among the newborns and young children. Besides reducing the burning of fossil fuels as the ultimate solution of smog formation, advanced methods by using various physical, chemical, and biological means to reduce sulfur and nitrogen contains in fossil fuels could lower smog formation. Additionally, information on microbiota disruption, based on functional genomics, culturomics, and general ecological principles, should be included in the risk assessment of prolonged smog exposure to the health of human populations. Copyright © 2017. Published by Elsevier B.V.

  14. Cool Core Disruption in Abell 1763

    Science.gov (United States)

    Douglass, Edmund; Blanton, Elizabeth L.; Clarke, Tracy E.; Randall, Scott W.; Edwards, Louise O. V.; Sabry, Ziad

    2017-01-01

    We present the analysis of a 20 ksec Chandra archival observation of the massive galaxy cluster Abell 1763. A model-subtracted image highlighting excess cluster emission reveals a large spiral structure winding outward from the core to a radius of ~950 kpc. We measure the gas of the inner spiral to have significantly lower entropy than non-spiral regions at the same radius. This is consistent with the structure resulting from merger-induced motion of the cluster’s cool core, a phenomenon seen in many systems. Atypical of spiral-hosting clusters, an intact cool core is not detected. Its absence suggests the system has experienced significant disruption since the initial dynamical encounter that set the sloshing core in motion. Along the major axis of the elongated ICM distribution we detect thermal features consistent with the merger event most likely responsible for cool core disruption. The merger-induced transition towards non-cool core status will be discussed. The interaction between the powerful (P1.4 ~ 1026 W Hz-1) cluster-center WAT radio source and its ICM environment will also be discussed.

  15. Disrupting Law School: How Disruptive Innovation Will Revolutionize the Legal World

    Science.gov (United States)

    Pistone, Michele R.; Horn, Michael B.

    2016-01-01

    Facing dramatic declines in enrollment, revenue, and student quality at the same time that their cost structure continues to rise and public support has waned, law schools are in crisis. A key driver of the crisis is shrinking employment opportunities for recent graduates, which stem in part from the disruption of the traditional business model…

  16. Comparison of Advanced Machine Learning Tools for Disruption Prediction and Disruption Studies

    Czech Academy of Sciences Publication Activity Database

    Odstrčil, Michal; Murari, A.; Mlynář, Jan

    2013-01-01

    Roč. 41, č. 7 (2013), s. 1751-1759 ISSN 0093-3813 R&D Projects: GA ČR GAP205/10/2055 Institutional support: RVO:61389021 Keywords : Learning Machines * Support Vector Machines * Neural Network * ASDEX Upgrade * JET * Disruption mitigation * Tokamaks * ITER Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 0.950, year: 2013

  17. Disruptive Conduct: The Impact of Disruptive Technologies on Social Relations in Higher Education

    Science.gov (United States)

    Flavin, Michael

    2016-01-01

    Higher education institutions (HEIs) have invested significantly in digital technologies for learning and teaching. However, technologies provided by HEIs have not been universally successful in terms of adoption and usage. Meanwhile, both students and lecturers use disruptive technologies to support learning and teaching. This article examines…

  18. Tactile acuity is disrupted in osteoarthritis but is unrelated to disruptions in motor imagery performance.

    NARCIS (Netherlands)

    Stanton, T.R.; Lin, C.W.; Bray, H.; Smeets, R.J.P.; Taylor, D.; Law, R.Y.; Moseley, G.L.

    2013-01-01

    OBJECTIVE: To determine whether tactile acuity is disrupted in people with knee OA and to determine whether tactile acuity, a clinical signature of primary sensory cortex representation, is related to motor imagery performance (MIP; evaluates working body schema) and pain. METHODS: Experiment 1:

  19. Disruptive change and the reconfiguration of innovation ecosystems

    Directory of Open Access Journals (Sweden)

    Ozgur Dedehayir

    2017-10-01

    Full Text Available This conceptual paper extends the traditional view of disruptive change, which considers the effects of rivalry between an incumbent and new entrant firm, by examining the impact of disruption upon the ‘innovation ecosystem’ in its entirety – the group of organisations that collaborate in creating a holistic value proposition for the end-user. Following Adner’s “ecosystem-as-structure” perspective, we develop propositions that anticipate structural differences between incumbent and disruptive innovation ecosystems, and then review these propositions in the context of three historical, disruptive innovation cases; Bakelite (a synthetic plastic, microwave oven, and photocopier. Through these cases, we illustrate that the manner of innovation ecosystem reconfiguration is likely to depend on the design attributes of the product, as well as the type of disruption experienced. We conclude by reflecting upon contemporary cases of disruption enabled through digital technologies, and proposing a framework that can guide future research.

  20. Disruption of Conscious Access in Schizophrenia.

    Science.gov (United States)

    Berkovitch, Lucie; Dehaene, Stanislas; Gaillard, Raphaël

    2017-11-01

    Schizophrenia is a severe and complex psychiatric disorder resulting in delusions, hallucinations, and cognitive impairments. Across a variety of paradigms, an elevated threshold for conscious perception has been repeatedly observed in persons with schizophrenia. Remarkably, even subtle measures of subliminal processing appear to be preserved. We argue here that the dissociation between impaired conscious access and intact unconscious processing may be due to a specific disruption of top-down attentional amplification. This proposal is compatible with the neurophysiological disturbances observed in schizophrenia, including dysconnectivity, abnormal neural oscillations, and glutamatergic and cholinergic dysregulation. Therefore, placing impaired conscious access as a central feature of schizophrenia can help researchers develop a coherent and parsimonious pathophysiological framework of the disease. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Endocrine disrupter - estradiol - in Chesapeake Bay tributaries

    Energy Technology Data Exchange (ETDEWEB)

    Dorabawila, Nelum [University of Maryland Eastern Shore, Princess Anne, MD 21853 (United States); Gupta, Gian [University of Maryland Eastern Shore, Princess Anne, MD 21853 (United States)]. E-mail: gcgupta@umes.edu

    2005-04-11

    Exogenous chemicals that interfere with natural hormonal functions are considered endocrine disrupting chemicals (EDCs). Estradiol (17{beta}-estradiol or E2) is the most potent of all xenoestrogens. Induction of vitellogenin (VTG) production in male fish occurs at E2 concentrations as low as 1 ng l{sup -1}. E2 reaches aquatic systems mainly through sewage and animal waste disposal. Surface water samples from ponds, rivers (Wicomico, Manokin and Pocomoke), sewage treatment plants (STPs), and coastal bays (Assawoman, Monie, Chincoteague, and Tangier Sound - Chesapeake Bay) on the Eastern Shore of Maryland were analyzed for E2 using enzyme linked immuno-sorbent assay (ELISA). E2 concentrations in river waters varied between 1.9 and 6.0 ng l{sup -1}. Highest E2 concentrations in river waters were observed immediately downstream of STPs. E2 concentrations in all the coastal bays tested were 2.3-3.2 ng l{sup -1}.

  2. Endocrine disrupter - estradiol - in Chesapeake Bay tributaries

    International Nuclear Information System (INIS)

    Dorabawila, Nelum; Gupta, Gian

    2005-01-01

    Exogenous chemicals that interfere with natural hormonal functions are considered endocrine disrupting chemicals (EDCs). Estradiol (17β-estradiol or E2) is the most potent of all xenoestrogens. Induction of vitellogenin (VTG) production in male fish occurs at E2 concentrations as low as 1 ng l -1 . E2 reaches aquatic systems mainly through sewage and animal waste disposal. Surface water samples from ponds, rivers (Wicomico, Manokin and Pocomoke), sewage treatment plants (STPs), and coastal bays (Assawoman, Monie, Chincoteague, and Tangier Sound - Chesapeake Bay) on the Eastern Shore of Maryland were analyzed for E2 using enzyme linked immuno-sorbent assay (ELISA). E2 concentrations in river waters varied between 1.9 and 6.0 ng l -1 . Highest E2 concentrations in river waters were observed immediately downstream of STPs. E2 concentrations in all the coastal bays tested were 2.3-3.2 ng l -1

  3. Features, Events, and Processes: Disruptive Events

    International Nuclear Information System (INIS)

    J. King

    2004-01-01

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report

  4. Metabolism Disrupting Chemicals and Metabolic Disorders

    Science.gov (United States)

    Heindel, Jerrold J.; Blumberg, Bruce; Cave, Mathew; Machtinger, Ronit; Mantovani, Alberto; Mendez, Michelle A.; Nadal, Angel; Palanza, Paola; Panzica, Giancarlo; Sargis, Robert; Vandenberg, Laura N.; Saal, Frederick vom

    2016-01-01

    The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome. We will specifically examine evidence linking EDC exposures during critical periods of development with metabolic diseases that manifest later in life and across generations. PMID:27760374

  5. Disruptive Innovation in Chinese and Indian Businesses

    DEFF Research Database (Denmark)

    With the rapid development of China and India as new economic powers in global competition, an obvious question is whether these emerging economies are great opportunities or threats. Whilst answers are bound to differ depending on one's perspective, it is increasingly clear that more local firms......, especially local entrepreneurs, from these emerging economies will play a more critical role in global competition by becoming challengers to global incumbents. Indeed, the fact that the majority of their populations are at the bottom of the pyramid, and thus cannot afford products designed for the developed...... or services, which originate in lower-end market segments, but later move up to compete with those provided by incumbent firms. This book sheds new light on disruptive innovations both from and for the bottom of the pyramid in China and India, from the point of view of local entrepreneurs and international...

  6. Disruptions seen arising from nuclear rate shock

    International Nuclear Information System (INIS)

    Utroska, D.

    1984-01-01

    Recent reports by the public utility industry and Price Waterhouse conclude that the rate shock associated with some of the over 40 nuclear plants coming on-line in the next few years could disrupt local economies and change the way certain crisis-state electric companies report their financial dealings. Passing the full cost of a plant along to ratepayers can result in a direct reduction in electricity demand and a corresponding flight of consumers from the region. Another effect may be to eliminate allowance for funds used during construction (AFUDC) as an accounting tool if there is no possibility of recovering costs from ratepayers. One report estimates that the lifetime value of nuclear plant costs will likely exceed lifetime fuel savings by $82 to $266 billion. Rate phase-in could mitigate the shock and make it more equitable. 1 table

  7. The Disruptive Effect of Think Aloud

    DEFF Research Database (Denmark)

    Nielsen, Janni; Yssing, Carsten

    Thinking Aloud Thinking Aloud is the most commonly used technique used to test users´ interaction with computers. The assumption is that Think Aloud gives access to what goes on in the users´ minds. However, interfaces are multi modal and play heavily on user´s visual perception. Reflecting upon...... Think Aloud (TA), we ask the question: what happens when users are required to verbalise their visual perceptions and interactions? We argue that TA may have a disruptive effect, suggesting that other techniques be considered. With a theoretical distinction between focal and subsidiary awareness...... and a focus on the sense making process, we develop a frame for test of user´s visual interaction which rely on the coordination between hand/mouse and eye/cursor.Author Keywords: Think Aloud, visual perception, interaction, test...

  8. Action-specific disruption of perceptual confidence.

    Science.gov (United States)

    Fleming, Stephen M; Maniscalco, Brian; Ko, Yoshiaki; Amendi, Namema; Ro, Tony; Lau, Hakwan

    2015-01-01

    Theoretical models of perception assume that confidence is related to the quality or strength of sensory processing. Counter to this intuitive view, we showed in the present research that the motor system also contributes to judgments of perceptual confidence. In two experiments, we used transcranial magnetic stimulation (TMS) to manipulate response-specific representations in the premotor cortex, selectively disrupting postresponse confidence in visual discrimination judgments. Specifically, stimulation of the motor representation associated with the unchosen response reduced confidence in correct responses, thereby reducing metacognitive capacity without changing visual discrimination performance. Effects of TMS on confidence were observed when stimulation was applied both before and after the response occurred, which suggests that confidence depends on late-stage metacognitive processes. These results place constraints on models of perceptual confidence and metacognition by revealing that action-specific information in the premotor cortex contributes to perceptual confidence. © The Author(s) 2014.

  9. Disrupting neuronal transmission: Mechanism of DBS?

    Directory of Open Access Journals (Sweden)

    Satomi eChiken

    2014-03-01

    Full Text Available Applying high-frequency stimulation to deep brain rain structure, known as deep brain stimulation (DBS, has now been recognized an effective therapeutic option for a wide range of neurological and psychiatric disorders. DBS targeting the basal ganglia thalamo-cortical loop, especially the internal segment of the globus pallidus, subthalamic nucleus and thalamus, has been widely employed as a successful surgical therapy for movement disorders, such as Parkinson’s disease, dystonia and tremor. However, the neurophysiological mechanism underling the action of DBS remains unclear and is still under debate: does DBS inhibit or excite local neuronal elements? In this review, we will examine this question and propose the alternative interpretation: DBS dissociates inputs and outputs, resulting in disruption of abnormal signal transmission.

  10. Endocrine disrupting chemicals and growth of children.

    Science.gov (United States)

    Botton, Jérémie; Kadawathagedara, Manik; de Lauzon-Guillain, Blandine

    2017-06-01

    According to the "environmental obesogen hypothesis", early-life (including in utero) exposure to endocrine disrupting chemicals (EDCs) may disturb the mechanisms involved in adipogenesis or energy storage, and thus may increase the susceptibility to overweight and obesity. Animal models have shown that exposure to several of these chemicals could induce adipogenesis and mechanisms have been described. Epidemiological studies are crucial to know whether this effect could also be observed in humans. We aimed at summarizing the literature in epidemiology on the relationship between EDCs exposure and child's growth. Overall, epidemiological studies suggest that pre- and/or early postnatal exposure to some EDCs may increase the risk of overweight or obesity during childhood. In that review, we present some limitations of these studies, mainly in exposure assessment, that currently prevent to conclude about causality. Recent advances in epidemiology should bring further knowledge. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  11. The disruptive effect of Think Aloud

    DEFF Research Database (Denmark)

    Nielsen, Janni; Yssing, Carsten

    2004-01-01

    Thinking Aloud Thinking Aloud is the most commonly used technique used to test users´ interaction with computers. The assumption is that Think Aloud gives access to what goes on in the users´ minds. However, interfaces are multi modal and play heavily on user´s visual perception. Reflecting upon...... Think Aloud (TA), we ask the question: what happens when users are required to verbalise their visual perceptions and interactions? We argue that TA may have a disruptive effect, suggesting that other techniques be considered. With a theoretical distinction between focal and subsidiary awareness...... and a focus on the sense making process, we develop a frame for test of user´s visual interaction which rely on the coordination between hand/mouse and eye/cursor.Author Keywords: Think Aloud, visual perception, interaction, test...

  12. Features, Events, and Processes: Disruptive Events

    Energy Technology Data Exchange (ETDEWEB)

    J. King

    2004-03-31

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report.

  13. Identifikasi Pembayaran Bergerak (Mobile Payment) yang Mengganggu (Disruptive) di Indonesia

    OpenAIRE

    Mawarrini, Robertta Indira

    2017-01-01

    This research aims to identify disruptive mobile payment in Indonesia. Mobile payment as a sector of financial technology is enabling the lifestyle transformation of electronic banking. The future of retail banking is a smartphone experience that gladden and customers also aspire for a “bank in my pocket”. Mobile payment as the second sector most likely to be disrupted in the intersection of finance and technology industry. The promising approach of disruptive innovations is proposed by Profe...

  14. Disruption of Trophic Inhibitory Signaling in Autism Sepctrum Disorders

    Science.gov (United States)

    2016-12-01

    1 AWARD NUMBER: W81XWH-14-1-0433 TITLE: Disruption of Trophic Inhibitory Signaling in Autism Sepctrum Disorders PRINCIPAL INVESTIGATOR: Anis...SUBTITLE 5a. CONTRACT NUMBER Disruption of Trophic Inhibitory Signaling in Autism Sepctrum Disorders 5b. GRANT NUMBER W81XWH-14-1-0433 5c. PROGRAM...chloride co-transporters that control EGABA could be used as a corrective strategy for the synaptic and circuit disruptions demonstrated in the

  15. A bright year for tidal disruptions

    Science.gov (United States)

    Metzger, Brian D.; Stone, Nicholas C.

    2016-09-01

    When a star is tidally disrupted by a supermassive black hole (SMBH), roughly half of its mass falls back to the SMBH at super-Eddington rates. As this gas is tenuously gravitationally bound and unable to cool radiatively, only a small fraction fin ≪ 1 may accrete, with the majority instead becoming unbound in an outflow of velocity ˜104 km s-1. The outflow spreads laterally as it expands to large radii, encasing the SMBH and blocking the inner disc's EUV/X-ray radiation, which becomes trapped in a radiation-dominated nebula. Ionizing nebular radiation heats the inner edge of the ejecta, converting the emission to optical/near-UV wavelengths where photons more readily escape due to the lower opacity. This can explain the unexpectedly low and temporally constant effective temperatures of optically discovered tidal disruption event (TDE) flares. For high-mass SMBHs, M• ≳ 107 M⊙, the ejecta can become fully ionized at an earlier stage, or for a wider range of viewing angles, producing a TDE flare accompanied by thermal X-ray emission. The peak optical luminosity is suppressed as the result of adiabatic losses in the inner disc wind when M• ≪ 107 M⊙, possibly contributing to the unexpected dearth of optical TDEs in galaxies with low-mass SMBHs. In the classical picture, where fin ≈ 1, TDEs de-spin supermassive SMBHs and cap their maximum spins well below theoretical accretion physics limits. This cap is relaxed in our model, and existing Fe Kα spin measurements provide preliminary evidence that fin < 1.

  16. Technology and plasma-materials interaction processes of tokamak disruptions

    International Nuclear Information System (INIS)

    McGrath, R.T.; Kellman, A.G.

    1992-01-01

    A workshop on the technology and plasma-materials interaction processes of tokamak disruptions was held April 3, 1992 in Monterey, California, as a satellite meeting of the 10th International Conference on Plasma-Surface Interactions. The objective was to bring together researchers working on disruption measurements in operating tokamaks, those performing disruption simulation experiments using pulsed plasma gun, electron beam and laser systems, and computational physicists attempting to model the evolution and plasma-materials interaction processes of tokamak disruptions. This is a brief report on the workshop. 4 refs

  17. Stabilization of tearing modes to suppress major disruptions in tokamaks

    International Nuclear Information System (INIS)

    Holmes, J.A.; Carreras, B.; Hicks, H.R.; Lynch, S.J.; Waddell, B.V.

    1979-02-01

    It is shown, for q-profiles which lead to a disruption, that the control of the amplitude of the 2/1 tearing mode avoids the disruption. Q-profiles measured in T-4 and PLT before a major disruption were studied. Two methods of controlling the 2/1 mode amplitude have been considered: (1) Feedback stabilization with the feedback signal locked in phase with the 2/1 mode. (2) Heating slightly outside the q = 2 surface. In both cases it is only necessary to decrease the 2/1 mode amplitude to suppress the disruption. It is not always necessary to stabilize the unstable modes fully

  18. Short- and long-term health consequences of sleep disruption.

    Science.gov (United States)

    Medic, Goran; Wille, Micheline; Hemels, Michiel Eh

    2017-01-01

    Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic-pituitary-adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care

  19. A Preferred Home for Disrupted Stars

    Science.gov (United States)

    Kohler, Susanna

    2016-07-01

    Observed burps from the shredding of stars by supermassive black holes suggest that this behavior is more common in an unusual type of galaxy. A new study has examined NGC 3156, an example from this galaxy type, to better understand what causes this preference.Stellar BetrayalAn artists illustration of a tidal disruption event, in which a star is sent on a plunging orbit near a supermassive black hole and is subsequently torn apart by the black holes tidal forces. [NASA/CXC/M.Weiss]Tidal disruption events (TDEs) are events where a star plunges too close to a supermassive black hole and is torn apart by the black holes tidal forces. Weve observed roughly a dozen of these violent events in the last five years, and we expect to finds hundreds to thousands more with future surveys.TDEs are triggered when a star is sent on a plunging orbit close to a supermassive black hole. But what sends the star into harms way? One possible culprit is a dynamical mechanism known as two-body relaxation. In this process, stars orbiting a black hole undergo individual starstar interactions that, with a close enough encounter, can send them on plunging orbits.Choosing an Unusual HostOne puzzle with TDEs is that they tend to be preferentially found in rather unusual galaxies: galaxies that recently exhibited a lot of star formation but are now quiescent. In particular, several of the TDEs have been discovered in what are known as E+A galaxies, a rare subtype of elliptical galaxy that has recently undergone a major starburst.Since this subtype makes up only ~0.1% of all galaxies, its surprising that weve found so many TDEs in E+A galaxies so far. So why the preference?In an effort to answer this question, two scientists, Nicholas Stone (Einstein Fellow at Columbia University) and Sjoert van Velzen (Hubble Fellow at Johns Hopkins University), have teamed up to examine a nearby E+A galaxy, NGC 3156.Tidal disruption rates as a function of central supermassive-black-hole mass. The blue curve

  20. Novice Teachers' Opinions on Students' Disruptive Behaviours: A Case Study

    Science.gov (United States)

    Sezer, Senol

    2017-01-01

    Purpose: It is recognised worldwide that novice teachers encounter various disruptive behaviours and face many challenges that stem from problematic students. Disruptive behaviours are seen as some of the most pervasive challenges widely affecting the teaching experience of novice teachers. In this study, the aim was to determine novice teachers'…

  1. Teachers' Perceptions of Disruptive Behaviour in Schools: A Psychological Perspective

    Science.gov (United States)

    Nash, Poppy; Schlösser, Annette; Scarr, Tanya

    2016-01-01

    This article reports on an investigation into school teachers' perceptions of disruptive behaviour from a psychological perspective. The inter-disciplinary nature of this research bridges the understanding between educational and psychological perspectives on disruptive behaviour. This article discusses evidence that for the most troubled pupils,…

  2. Disruptive behaviour in the Foundation Phase of schooling | Marais ...

    African Journals Online (AJOL)

    Since the passage of legislation banning corporal punishment in South African schools, disruptive behaviour in schools has become an issue of national concern. Against this background a research project was undertaken in which the types and causes of disruptive behaviour occurring most frequently in the Foundation ...

  3. Disruptive Behaviour in the Foundation Phase of Schooling

    Science.gov (United States)

    Marais, Petro; Meier, Corinne

    2010-01-01

    Since the passage of legislation banning corporal punishment in South African schools, disruptive behaviour in schools has become an issue of national concern. Against this background a research project was undertaken in which the types and causes of disruptive behaviour occurring most frequently in the Foundation Phase of schooling were…

  4. Why looking at social media at work disrupts your concentration

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella; Wiewiura, Joachim Schmidt

    2016-01-01

    You might have heard of the bystander-effect, but what about the Pinball-effect, which disrupts your attention on important tasks?......You might have heard of the bystander-effect, but what about the Pinball-effect, which disrupts your attention on important tasks?...

  5. Plasma-material interaction under simulated disruption conditions

    International Nuclear Information System (INIS)

    Arkhipov, N.I.; Bakhtin, V.P.; Safronov, V.M.; Toporkov, D.A.; Vasenin, S.G.; Wurz, H.; Zhitlukhin, A.M.

    1995-01-01

    Sudden evaporation of divertor plate surface under high heat load during tokamak plasma disruption instantaneously produces a vapor shield. The cloud of vaporized material prevents the divertor plates from the bulk of incoming energy flux and thus reduces the further material erosion. Dynamics and effectiveness of the vapor shield are studied experimentally at the 2MK-200 facility under simulated disruption conditions. (orig.)

  6. In vitro screening for endocrine disruptive activity in selected South ...

    African Journals Online (AJOL)

    Various waterborne anthropogenic contaminants disrupt the endocrine systems of wildlife and humans, targeting reproductive pathways, among others. Very little is known, however, regarding the occurrence of endocrine disruptive activity in South African freshwater ecosystems, and coastal ecosystems have not been ...

  7. High trait anxiety: a challenge for disrupting fear memory reconsolidation

    NARCIS (Netherlands)

    Soeter, M.; Kindt, M.

    2013-01-01

    Disrupting reconsolidation may be promising in the treatment of anxiety disorders but the fear-reducing effects are thus far solely demonstrated in the average organism. A relevant question is whether disrupting fear memory reconsolidation is less effective in individuals who are vulnerable to

  8. Disruption management of the vehicle routing problem with vehicle breakdown

    DEFF Research Database (Denmark)

    Mu, Q; Fu, Z; Lysgaard, Jens

    2011-01-01

    This paper introduces a new class of problem, the disrupted vehicle routing problem (VRP), which deals with the disruptions that occur at the execution stage of a VRP plan. The paper then focuses on one type of such problem, in which a vehicle breaks down during the delivery and a new routing...

  9. Disruptive change and the reconfiguration of innovation ecosystems

    NARCIS (Netherlands)

    Dedehayir, Ozgur; Ortt, J.R.; Seppänen, Marko

    2017-01-01

    This conceptual paper extends the traditional view of disruptive change, which considers the effects of rivalry between an incumbent and new entrant firm, by examining the impact of disruption upon the ‘innovation ecosystem’ in its entirety – the group of organisations that collaborate in

  10. Biomarkers used in Environmental Health with focus on Endocrine Disrupters

    DEFF Research Database (Denmark)

    Krüger, Tanja; Ghisari, Mandana; Long, Manhai

    2012-01-01

    Endocrine-disrupting chemicals (EDCs) are compounds that either mimic or block endogenous hormones and can disrupt the normal function of the body. Bio-monitoring is the assessment of internal doses of EDCs and has been used for decades to provide information about exposures to chemicals giving...

  11. Disruption Management of Rolling Stock in Passenger Railway Transportation

    NARCIS (Netherlands)

    L.K. Nielsen (Lars Kjaer); G. Maróti (Gábor)

    2009-01-01

    textabstractThis paper deals with real-time disruption management of rolling stock in passenger railway transportation. We present a generic framework for modeling disruptions in railway rolling stock schedules. The framework is presented as an online combinatorial decision problem where the

  12. Railway disruption management challenges and possible solution directions

    NARCIS (Netherlands)

    Ghaemi, N.; Cats, O.; Goverde, R.M.P.

    2017-01-01

    This paper investigates the challenges of railway traffic controllers in dealing with big disruptions and the kind of support tools that could help to improve their task in terms of performance, lead time and workload. The disruption handling process can be partitioned into three phases

  13. Sleep disruption and the sequelae associated with traumatic brain injury.

    Science.gov (United States)

    Lucke-Wold, Brandon P; Smith, Kelly E; Nguyen, Linda; Turner, Ryan C; Logsdon, Aric F; Jackson, Garrett J; Huber, Jason D; Rosen, Charles L; Miller, Diane B

    2015-08-01

    Sleep disruption, which includes a loss of sleep as well as poor quality fragmented sleep, frequently follows traumatic brain injury (TBI) impacting a large number of patients each year in the United States. Fragmented and/or disrupted sleep can worsen neuropsychiatric, behavioral, and physical symptoms of TBI. Additionally, sleep disruption impairs recovery and can lead to cognitive decline. The most common sleep disruption following TBI is insomnia, which is difficulty staying asleep. The consequences of disrupted sleep following injury range from deranged metabolomics and blood brain barrier compromise to altered neuroplasticity and degeneration. There are several theories for why sleep is necessary (e.g., glymphatic clearance and metabolic regulation) and these may help explain how sleep disruption contributes to degeneration within the brain. Experimental data indicate disrupted sleep allows hyperphosphorylated tau and amyloid β plaques to accumulate. As sleep disruption may act as a cellular stressor, target areas warranting further scientific investigation include the increase in endoplasmic reticulum and oxidative stress following acute periods of sleep deprivation. Potential treatment options for restoring the normal sleep cycle include melatonin derivatives and cognitive behavioral therapy. Published by Elsevier Ltd.

  14. Plasma-material interaction under simulated disruption conditions

    Energy Technology Data Exchange (ETDEWEB)

    Arkhipov, N.I. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Bakhtin, V.P. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Safronov, V.M. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Toporkov, D.A. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Vasenin, S.G. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Wurz, H. [Kernforschungszentrum Karlsruhe, INR (Germany); Zhitlukhin, A.M. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation)

    1995-12-31

    Sudden evaporation of divertor plate surface under high heat load during tokamak plasma disruption instantaneously produces a vapor shield. The cloud of vaporized material prevents the divertor plates from the bulk of incoming energy flux and thus reduces the further material erosion. Dynamics and effectiveness of the vapor shield are studied experimentally at the 2MK-200 facility under simulated disruption conditions. (orig.).

  15. Supply Chain Disruptions Theory and Practice of Managing Risk

    CERN Document Server

    Mehrotra, Anuj; Ray, Saibal

    2012-01-01

    One of the most critical issues facing supply chain managers in today’s globalized and highly uncertain business environments is how to deal proactively with disruptions that might affect the complicated supply networks characterizing modern enterprises. Supply Chain Disruptions: Theory and Practice of Managing Risk presents a state-of the-art perspective on this particular issue. Supply Chain Disruptions: Theory and Practice of Managing Risk demonstrates that effective management of supply disruptions necessitates both strategic and tactical measures – the former involving optimal design of supply networks; the latter involving inventory, finance and demand management. It shows that managers ought to use all available levers at their disposal throughout the supply network – like sourcing and pricing strategies, providing financial subsidies, encouraging information sharing and incentive alignment between supply chain partners – in order to tackle supply disruptions. The editors combine up-to-date aca...

  16. Neuroimaging findings in disruptive behavior disorders.

    Science.gov (United States)

    Baker, Rosalind H; Clanton, Roberta L; Rogers, Jack C; De Brito, Stéphane A

    2015-08-01

    Decades of research have shown that youths with disruptive behavior disorders (DBD) are a heterogeneous population. Over the past 20 years, researchers have distinguished youths with DBD as those displaying high (DBD/HCU) versus low (DBD/LCU) callous-unemotional (CU) traits. These traits include flat affect and reduced empathy and remorse, and are associated with more severe, varied, and persistent patterns of antisocial behavior and aggression. Conduct problems in youths with HCU and LCU are thought to reflect distinct causal vulnerabilities, with antisocial behavior in youths with DBD/HCU reflecting a predominantly genetic etiology, while antisocial behavior in youths with DBD/LCU is associated primarily with environmental influences. Here we selectively review recent functional (fMRI) and structural (sMRI) magnetic resonance imaging research on DBD, focusing particularly on the role of CU traits. First, fMRI studies examining the neural correlates of affective stimuli, emotional face processing, empathy, theory of mind, morality, and decision-making in DBD are discussed. This is followed by a review of the studies investigating brain structure and structural connectivity in DBD. Next, we highlight the need to further investigate females and the role of sex differences in this population. We conclude the review by identifying potential clinical implications of this research.

  17. Fungal laccases degradation of endocrine disrupting compounds.

    Science.gov (United States)

    Macellaro, Gemma; Pezzella, Cinzia; Cicatiello, Paola; Sannia, Giovanni; Piscitelli, Alessandra

    2014-01-01

    Over the past decades, water pollution by trace organic compounds (ng/L) has become one of the key environmental issues in developed countries. This is the case of the emerging contaminants called endocrine disrupting compounds (EDCs). EDCs are a new class of environmental pollutants able to mimic or antagonize the effects of endogenous hormones, and are recently drawing scientific and public attention. Their widespread presence in the environment solicits the need of their removal from the contaminated sites. One promising approach to face this challenge consists in the use of enzymatic systems able to react with these molecules. Among the possible enzymes, oxidative enzymes are attracting increasing attention because of their versatility, the possibility to produce them on large scale, and to modify their properties. In this study five different EDCs were treated with four different fungal laccases, also in the presence of both synthetic and natural mediators. Mediators significantly increased the efficiency of the enzymatic treatment, promoting the degradation of substrates recalcitrant to laccase oxidation. The laccase showing the best performances was chosen to further investigate its oxidative capabilities against micropollutant mixtures. Improvement of enzyme performances in nonylphenol degradation rate was achieved through immobilization on glass beads.

  18. Disruption of myelination by diagnostic US

    International Nuclear Information System (INIS)

    Ellisman, M.H.; Palmer, D.E.; Andre, M.P.

    1986-01-01

    In order to test for possible effects of US on myelination, the authors exposed 20 unanesthetized rat pups to US intensities consistent with those used for imaging a human fetus in utero. The rats were 3-5 days old and at a stage of myelination similar to that of a human fetus of about 4-5 months. Then animals were exposed for 30 minutes to the beam from a 3.5-MHz transducer (ADR 2130 real-time linear array, SPTA intensity of 0.4 mW/cm/sup 2/ and SATA intensity of 0.05 mW/cm/sup 2/). Control animals were bound and placed in the tank but not exposed for 30 minutes, and taken straight from the cage. Some animals were killed and tissues were processed for electron microscopy immediately after exposure, others were killed after recovery periods of up to 24 hours. Enlargements of the periaxonal space was visible with separation of adjacent paranodal loops and disruption of Schwann cell-axonal junctions in all exposed animals. Paranodal demyelination was also noted in several nodes. Nodes exhibiting this microedematous morphology were apparent even after a 24-hour recovery period but were not found in control preparations

  19. Disrupted functional connectivity in adolescent obesity.

    Science.gov (United States)

    Moreno-Lopez, Laura; Contreras-Rodriguez, Oren; Soriano-Mas, Carles; Stamatakis, Emmanuel A; Verdejo-Garcia, Antonio

    2016-01-01

    Obesity has been associated with brain alterations characterised by poorer interaction between a hypersensitive reward system and a comparatively weaker prefrontal-cognitive control system. These alterations may occur as early as in adolescence, but this notion remains unclear, as no studies so far have examined global functional connectivity in adolescents with excess weight. We investigated functional connectivity in a sample of 60 adolescents with excess weight and 55 normal weight controls. We first identified parts of the brain displaying between-group global connectivity differences and then characterised the extent of the differences in functional network integrity and their association with reward sensitivity. Adolescent obesity was linked to neuroadaptations in functional connectivity within brain hubs linked to interoception (insula), emotional memory (middle temporal gyrus) and cognitive control (dorsolateral prefrontal cortex) (pFWE adolescent obesity is linked to disrupted functional connectivity in brain networks relevant to maintaining balance between reward, emotional memories and cognitive control. Our findings may contribute to reconceptualization of obesity as a multi-layered brain disorder leading to compromised motivation and control, and provide a biological account to target prevention strategies for adolescent obesity.

  20. Disruptive innovation: the future of healthcare?

    Science.gov (United States)

    Yellowlees, Peter; Odor, Alberto; Patrice, Kesha; Parish, Michelle Burke; Nafiz, Najia; Iosif, Ana-Maria; Hilty, Donald

    2011-04-01

    The traditional face-to-face doctor-patient relationship is the core of conventional medical practice. One key aspect of this changing relationship is the increasing dependency on asynchronous data collection in clinical consultations. Such electronic communications and data streams may be numeric, text-based, audio, digitized still pictures, video and radiologic, as well as emanating from multiple medical devices. While asynchronous medicine may be established in specialties like radiology and dermatology, there is little research regarding the use of asynchronous medicine in areas of medicine that traditionally rely on the physical doctor-patient interaction such as primary care, internal medicine, geriatrics, and psychiatry. The practice of psychiatry stands out as a discipline that is highly dependent on the quality of the physical meeting between the doctor and the patient, yet even in this specialty it is possible to utilize asynchronous medicine for some types of psychiatric consultations. Asynchronous medicine has the potential to be significantly disruptive to our current healthcare processes, as well as more clinically and economically efficient.

  1. Reward disrupts reactivated human skill memory.

    Science.gov (United States)

    Dayan, Eran; Laor-Maayany, Rony; Censor, Nitzan

    2016-06-16

    Accumulating evidence across species and memory domains shows that when an existing memory is reactivated, it becomes susceptible to modifications. However, the potential role of reward signals in these mechanisms underlying human memory dynamics is unknown. Leaning on a wealth of findings on the role of reward in reinforcing memory, we tested the impact of reinforcing a skill memory trace with monetary reward following memory reactivation, on strengthening of the memory trace. Reinforcing reactivated memories did not strengthen the memory, but rather led to disruption of the memory trace, breaking down the link between memory reactivation and subsequent memory strength. Statistical modeling further revealed a strong mediating role for memory reactivation in linking between memory encoding and subsequent memory strength only when the memory was replayed without reinforcement. We suggest that, rather than reinforcing the existing memory trace, reward creates a competing memory trace, impairing expression of the original reward-free memory. This mechanism sheds light on the processes underlying skill acquisition, having wide translational implications.

  2. Passive hand movements disrupt adults’ counting strategies

    Directory of Open Access Journals (Sweden)

    Ineke eImbo

    2011-09-01

    Full Text Available In the present study, we experimentally tested the role of hand motor circuits in simple-arithmetic strategies. Educated adults solved simple additions (e.g., 8+3 or simple subtractions (e.g., 11–3 while they were required to retrieve the answer from long-term memory (e.g., knowing that 8+3 = 11, to transform the problem by making an intermediate step (e.g., 8+3 = 8+2+1 = 10+1 = 11 or to count one-by-one (e.g., 8+3 = 8…9…10…11. During the process of solving the arithmetic problems, the experimenter did or did not move the participants’ hand on a 4-point matrix. The results show that passive hand movements disrupted the counting strategy while leaving the other strategies unaffected. This pattern of results is in agreement with a procedural account, showing that the involvement of hand motor circuits in adults’ mathematical abilities is reminiscent of finger counting during childhood.

  3. Oncogenomic disruptions in arsenic-induced carcinogenesis.

    Science.gov (United States)

    Sage, Adam P; Minatel, Brenda C; Ng, Kevin W; Stewart, Greg L; Dummer, Trevor J B; Lam, Wan L; Martinez, Victor D

    2017-04-11

    Chronic exposure to arsenic affects more than 200 million people worldwide, and has been associated with many adverse health effects, including cancer in several organs. There is accumulating evidence that arsenic biotransformation, a step in the elimination of arsenic from the human body, can induce changes at a genetic and epigenetic level, leading to carcinogenesis. At the genetic level, arsenic interferes with key cellular processes such as DNA damage-repair and chromosomal structure, leading to genomic instability. At the epigenetic level, arsenic places a high demand on the cellular methyl pool, leading to global hypomethylation and hypermethylation of specific gene promoters. These arsenic-associated DNA alterations result in the deregulation of both oncogenic and tumour-suppressive genes. Furthermore, recent reports have implicated aberrant expression of non-coding RNAs and the consequential disruption of signaling pathways in the context of arsenic-induced carcinogenesis. This article provides an overview of the oncogenomic anomalies associated with arsenic exposure and conveys the importance of non-coding RNAs in the arsenic-induced carcinogenic process.

  4. Disruption in the diabetic device care market

    Directory of Open Access Journals (Sweden)

    Ojha U

    2018-02-01

    Full Text Available Utkarsh Ojha,1 Raihan Mohammed2 1Faculty of Medicine, Imperial College School of Medicine, Imperial College London, London, UK; 2Department of Medicine, University of Cambridge, Cambridge, UK Abstract: As diabetes mellitus (DM has approached pandemic proportions, the pressure for effective glycemic management is mounting. The starting point for managing and living well with DM involves early diagnosis and monitoring blood glucose levels. Therefore, self-monitoring of blood glucose (SMBG can help patients maintain their blood glucose levels within the appropriate range. The general principle behind the current SMBG method involves a finger prick test to obtain a blood drop, which is applied onto a reagent strip and read by an automated device. Novel techniques are currently under evaluation to create the next generation of painless and accurate glucose monitoring for DM. We began by outlining how the emerging technology of the noninvasive glucose monitoring devices (NIGMDs provides both economic and clinical benefits for health systems and patients. We further explored the engineering and techniques behind these upcoming devices. Finally, we evaluated how the NIGMDs disrupt the diabetic device care market and drive health care consumerism. We postulated that the NIGMDs play a pivotal role in the implementation of next generation of diabetes prevention strategies. Keywords: medical devices, medical technology, diabetes management, innovation

  5. Lesbian disclosure: disrupting the taken for granted.

    Science.gov (United States)

    McDonald, Carol

    2009-03-01

    The purpose of this interpretive inquiry was to generate understandings about the experience of lesbian disclosure. The inquiry relied on Gadamerian hermeneutic and feminist philosophical thought and was situated in women's health. In a feminist understanding of women's health, experiences of health are inseparable from the everyday experiences of an embodied life and are constituted within each woman's social, material, and discursive realities.The study was informed by conversations with 15 women who self-identified as lesbian for the purpose of the inquiry, accounts of women in the media, and the researcher's reflective journals. The findings move us towards new understandings about the multiple meanings of "lesbian". "They challenge nurses to consider the binary categories of homosexual and heterosexual as inadequate signifiers for the reality of women's lives, to consider the particular arrangements of each woman's life, and to disrupt assumptions of heterosexism in order to reduce the negative impact of social exclusion, isolation, discrimination, and stigmatization as social determinants of health.

  6. Fungal Laccases Degradation of Endocrine Disrupting Compounds

    Directory of Open Access Journals (Sweden)

    Gemma Macellaro

    2014-01-01

    Full Text Available Over the past decades, water pollution by trace organic compounds (ng/L has become one of the key environmental issues in developed countries. This is the case of the emerging contaminants called endocrine disrupting compounds (EDCs. EDCs are a new class of environmental pollutants able to mimic or antagonize the effects of endogenous hormones, and are recently drawing scientific and public attention. Their widespread presence in the environment solicits the need of their removal from the contaminated sites. One promising approach to face this challenge consists in the use of enzymatic systems able to react with these molecules. Among the possible enzymes, oxidative enzymes are attracting increasing attention because of their versatility, the possibility to produce them on large scale, and to modify their properties. In this study five different EDCs were treated with four different fungal laccases, also in the presence of both synthetic and natural mediators. Mediators significantly increased the efficiency of the enzymatic treatment, promoting the degradation of substrates recalcitrant to laccase oxidation. The laccase showing the best performances was chosen to further investigate its oxidative capabilities against micropollutant mixtures. Improvement of enzyme performances in nonylphenol degradation rate was achieved through immobilization on glass beads.

  7. Plasma temperature measurements in disruption simulated experiment

    Energy Technology Data Exchange (ETDEWEB)

    Arkhipov, N.I. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Bakhtin, V.P. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Safronov, V.M. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Toporkov, D.A. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Vasenin, S.G. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation); Wurz, H. [Kernforschungszentrum Karlsruhe, INR (Germany); Zhitlukhin, A.M. [Troitsk Inst. for Innovation and Fusion Research (Russian Federation)

    1995-12-31

    Results are reported of experiments to measure the temporal and spatial distributions of a temperature and radiation of a near surface plasma cloud appearing in the disruption simulated experiments. These measurements are needed to verificate the different numerical models of vapor shielding layer which appears to arise near the divertor plates surface and prevents them from the bulk of the incoming energy. Experiments with graphite and tungsten samples were carried out at the 2MK-200 plasma facility. Long CUSP trap was used as a source of high temperature deuterium plasma with a power density W = 10 MW/cm{sup 2} and time duration t = 20 mcs. Laser scattering, space and time resolved soft x-ray spectroscopy was employed to measure the plasma cloud temperature and radiation. The different behaviour of shielding layer parameters was shown for a graphite and tungsten samples. For a tungsten the sharp boundary existed between the incoming deuterium plasma and the thin layer of ablated material plasma and the strong gradient of electron temperature took place in this zone. For a graphite this boundary was broadened at the distance and the main part of the screening layer consisted of the mixture of the incoming deuterium and ablated carbon plasma. (orig.).

  8. Real Time Simulation of Power Grid Disruptions

    Energy Technology Data Exchange (ETDEWEB)

    Chinthavali, Supriya [ORNL; Dimitrovski, Aleksandar D [ORNL; Fernandez, Steven J [ORNL; Groer, Christopher S [ORNL; Nutaro, James J [ORNL; Olama, Mohammed M [ORNL; Omitaomu, Olufemi A [ORNL; Shankar, Mallikarjun [ORNL; Spafford, Kyle L [ORNL; Vacaliuc, Bogdan [ORNL

    2012-11-01

    DOE-OE and DOE-SC workshops (Reference 1-3) identified the key power grid problem that requires insight addressable by the next generation of exascale computing is coupling of real-time data streams (1-2 TB per hour) as the streams are ingested to dynamic models. These models would then identify predicted disruptions in time (2-4 seconds) to trigger the smart grid s self healing functions. This project attempted to establish the feasibility of this approach and defined the scientific issues, and demonstrated example solutions to important smart grid simulation problems. These objectives were accomplished by 1) using the existing frequency recorders on the national grid to establish a representative and scalable real-time data stream; 2) invoking ORNL signature identification algorithms; 3) modeling dynamically a representative region of the Eastern interconnect using an institutional cluster, measuring the scalability and computational benchmarks for a national capability; and 4) constructing a prototype simulation for the system s concept of smart grid deployment. The delivered ORNL enduring capability included: 1) data processing and simulation metrics to design a national capability justifying exascale applications; 2) Software and intellectual property built around the example solutions; 3) demonstrated dynamic models to design few second self-healing.

  9. Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption.

    Science.gov (United States)

    Veiga-Lopez, A; Moeller, J; Abbott, D H; Padmanabhan, V

    2016-06-29

    Prenatal testosterone (T) excess from days 30-90 of gestation disrupts gonadotropin surge and ovarian follicular dynamics and induces insulin resistance and functional hyperandrogenism in sheep. T treatment from days 60-90 of gestation produces a milder phenotype, albeit with reduced fecundity. Using this milder phenotype, the aim of this study was to understand the relative postnatal contributions of androgen and insulin in mediating the prenatal T induced disruptions in ovarian follicular dynamics. Four experimental groups were generated: 1) control (vehicle treatment), 2) prenatal T-treated (100 mg i.m. administration of T propionate twice weekly from days 60-90 of gestation), 3) prenatal T plus postnatal anti-androgen treated (daily oral dose of 15 mg/kg/day of flutamide beginning at 8 weeks of age) and 4) prenatal T and postnatal insulin sensitizer-treated (daily oral dose of 8 mg/day rosiglitazone beginning at 8 weeks of age). Follicular response to a controlled ovarian stimulation protocol was tested during their third breeding season. Main outcome measures included the determination of number and size of ovarian follicles and intrafollicular concentrations of steroids. At the end of the controlled ovarian stimulation, the number of follicles approaching ovulatory size (≥6 mm) were ~35 % lower in prenatal T-treated (6.5 ± 1.8) compared to controls (9.8 ± 2.0). Postnatal anti-androgen (10.3 ± 1.9), but not insulin sensitizer (5.0 ± 0.9), treatment prevented this decrease. Preovulatory sized follicles in the T group had lower intrafollicular T, androstenedione, and progesterone compared to that of the control group. Intrafollicular steroid disruption was partially reversed solely by postnatal insulin sensitizer treatment. These results demonstrate that the final preovulatory follicular growth and intrafollicular steroid milieu is impaired in prenatal T-treated females. The findings are consistent with the lower fertility rate

  10. Disrupted functional connectome in antisocial personality disorder.

    Science.gov (United States)

    Jiang, Weixiong; Shi, Feng; Liao, Jian; Liu, Huasheng; Wang, Tao; Shen, Celina; Shen, Hui; Hu, Dewen; Wang, Wei; Shen, Dinggang

    2017-08-01

    Studies on antisocial personality disorder (ASPD) subjects focus on brain functional alterations in relation to antisocial behaviors. Neuroimaging research has identified a number of focal brain regions with abnormal structures or functions in ASPD. However, little is known about the connections among brain regions in terms of inter-regional whole-brain networks in ASPD patients, as well as possible alterations of brain functional topological organization. In this study, we employ resting-state functional magnetic resonance imaging (R-fMRI) to examine functional connectome of 32 ASPD patients and 35 normal controls by using a variety of network properties, including small-worldness, modularity, and connectivity. The small-world analysis reveals that ASPD patients have increased path length and decreased network efficiency, which implies a reduced ability of global integration of whole-brain functions. Modularity analysis suggests ASPD patients have decreased overall modularity, merged network modules, and reduced intra- and inter-module connectivities related to frontal regions. Also, network-based statistics show that an internal sub-network, composed of 16 nodes and 16 edges, is significantly affected in ASPD patients, where brain regions are mostly located in the fronto-parietal control network. These results suggest that ASPD is associated with both reduced brain integration and segregation in topological organization of functional brain networks, particularly in the fronto-parietal control network. These disruptions may contribute to disturbances in behavior and cognition in patients with ASPD. Our findings may provide insights into a deeper understanding of functional brain networks of ASPD.

  11. Disruptive Event Biosphere Doser Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. Wasiolek

    2000-12-28

    The purpose of this report was to document the process leading to, and the results of, development of radionuclide-, exposure scenario-, and ash thickness-specific Biosphere Dose Conversion Factors (BDCFs) for the postulated postclosure extrusive igneous event (volcanic eruption) at Yucca Mountain. BDCF calculations were done for seventeen radionuclides. The selection of radionuclides included those that may be significant dose contributors during the compliance period of up to 10,000 years, as well as radionuclides of importance for up to 1 million years postclosure. The approach documented in this report takes into account human exposure during three different phases at the time of, and after, volcanic eruption. Calculations of disruptive event BDCFs used the GENII-S computer code in a series of probabilistic realizations to propagate the uncertainties of input parameters into the output. The pathway analysis included consideration of different exposure pathway's contribution to the BDCFs. BDCFs for volcanic eruption, when combined with the concentration of radioactivity deposited by eruption on the soil surface, allow calculation of potential radiation doses to the receptor of interest. Calculation of radioactivity deposition is outside the scope of this report and so is the transport of contaminated ash from the volcano to the location of the receptor. The integration of the biosphere modeling results (BDCFs) with the outcomes of the other component models is accomplished in the Total System Performance Assessment (TSPA), in which doses are calculated to the receptor of interest from radionuclides postulated to be released to the environment from the potential repository at Yucca Mountain.

  12. Ecosystem regime shifts disrupt trophic structure.

    Science.gov (United States)

    Hempson, Tessa N; Graham, Nicholas A J; MacNeil, M Aaron; Hoey, Andrew S; Wilson, Shaun K

    2018-01-01

    Regime shifts between alternative stable ecosystem states are becoming commonplace due to the combined effects of local stressors and global climate change. Alternative states are characterized as substantially different in form and function from pre-disturbance states, disrupting the delivery of ecosystem services and functions. On coral reefs, regime shifts are typically characterized by a change in the benthic composition from coral to macroalgal dominance. Such fundamental shifts in the benthos are anticipated to impact associated fish communities that are reliant on the reef for food and shelter, yet there is limited understanding of how regime shifts propagate through the fish community over time, relative to initial or recovery conditions. This study addresses this knowledge gap using long-term data of coral reef regime shifts and recovery on Seychelles reefs following the 1998 mass bleaching event. It shows how trophic structure of the reef fish community becomes increasingly dissimilar between alternative reef ecosystem states (regime-shifted vs. recovering) with time since disturbance. Regime-shifted reefs developed a concave trophic structure, with increased biomass in base trophic levels as herbivorous species benefitted from increased algal resources. Mid trophic level species, including specialists such as corallivores, declined with loss of coral habitat, while biomass was retained in upper trophic levels by large-bodied, generalist invertivores. Recovering reefs also experienced an initial decline in mid trophic level biomass, but moved toward a bottom-heavy pyramid shape, with a wide range of feeding groups (e.g., planktivores, corallivores, omnivores) represented at mid trophic levels. Given the importance of coral reef fishes in maintaining the ecological function of coral reef ecosystems and their associated fisheries, understanding the effects of regime shifts on these communities is essential to inform decisions that enhance ecological

  13. Dexamethasone Chemotherapy Does Not Disrupt Orexin Signaling

    Science.gov (United States)

    Kram, David E.; Krasnow, Stephanie M.; Levasseur, Peter R.; Zhu, Xinxia; Stork, Linda C.

    2016-01-01

    Background Steroid-induced sleep disturbance is a common and highly distressing morbidity for children receiving steroid chemotherapy for the treatment of pediatric acute lymphoblastic leukemia (ALL). Sleep disturbance can negatively impact overall quality of life, neurodevelopment, memory consolidation, and wound healing. Hypothalamic orexin neurons are influential wake-promoting neurons, and disturbances in orexin signaling leads to abnormal sleep behavior. A new class of drug, the orexin receptor antagonists, could be an intriguing option for sleep disorders caused by increased orexinergic output. Our aim was to examine the impact of ALL treatment doses of corticosteroids on the orexin system in rodents and in children undergoing treatment for childhood ALL. Methods We administered repeated injections of dexamethasone to rodents and measured responsive orexin neural activity compared to controls. In children with newly diagnosed standard risk B-cell ALL receiving dexamethasone therapy per Children’s Oncology Group (COG) induction therapy from 2014–2016, we collected pre- and during-steroids matched CSF samples and measured the impact of steroids on CSF orexin concentration. Results In both rodents, all markers orexin signaling, including orexin neural output and orexin receptor expression, were preserved in the setting of dexamethasone. Additionally, we did not detect a difference in pre- and during-dexamethasone CSF orexin concentrations in children receiving dexamethasone. Conclusions Our results demonstrate that rodent and human orexin physiology is largely preserved in the setting of high dose dexamethasone. The data obtained in our experimental model fail to demonstrate a causative role for disruption of the orexin pathway in steroid-induced sleep disturbance. PMID:27997622

  14. Cost Sharing in the Prevention of Supply Chain Disruption

    Directory of Open Access Journals (Sweden)

    Wen Wang

    2017-01-01

    Full Text Available We examine the influence of cost-sharing mechanism on the disruption prevention investment in a supply chain with unreliable suppliers. When a supply chain faces considerable loss following a disruption, supply chain members are motivated toward investing in manners that reduce their disruption probability. In improving supply chain reliability, the cost-sharing mechanism must be set appropriately to realize the efficiency of the disruption prevention investment. In a supply chain where the focal manufacturing company has its own subsidiary supplier and an outsourcing supplier, we analyze different forms of cost-sharing mechanisms when both suppliers confront disruption risks. Through the cost-sharing mechanisms presented in this study, supply chain members can improve their reliability via disruption prevention investments without considerably increasing the total supply chain cost. We present two concepts, the cost-sharing structure and the cost-sharing ratio, in this study. As the two key components of cost-sharing mechanism, these two elements constitute a practicable cost allocation mechanism to facilitate disruption prevention.

  15. Enzymatic cell disruption of microalgae biomass in biorefinery processes.

    Science.gov (United States)

    Demuez, Marie; Mahdy, Ahmed; Tomás-Pejó, Elia; González-Fernández, Cristina; Ballesteros, Mercedes

    2015-10-01

    When employing biotechnological processes for the procurement of biofuels and bio-products from microalgae, one of the most critical steps affecting economy and yields is the "cell disruption" stage. Currently, enzymatic cell disruption has delivered effective and cost competitive results when compared to mechanical and chemical cell disruption methods. However, the introduction of enzymes implies additional associated cost within the overall process. In order to reduce this cost, autolysis of microalgae is proposed as alternative enzymatic cell disruption method. This review aims to provide the state of the art of enzymatic cell disruption treatments employed in biorefinery processes and highlights the use of endopeptidases. During the enzymatic processes of microalgae life cycle, some lytic enzymes involved in cell division and programmed cell death have been proven useful in performing cell lysis. In this context, the role of endopeptidases is emphasized. Mirroring these natural events, an alternative cell disruption approach is proposed and described with the potential to induce the autolysis process using intrinsic cell enzymes. Integrating induced autolysis within biofuel production processes offers a promising approach to reduce overall global costs and energetic input associated with those of current cell disruption methods. A number of options for further inquiry are also discussed. © 2015 Wiley Periodicals, Inc.

  16. On the computation of the disruption forces in tokamaks

    Science.gov (United States)

    Pustovitov, V. D.; Rubinacci, G.; Villone, F.

    2017-12-01

    The currents and forces induced in the tokamak vacuum vessel (wall) during the disruption are calculated for different values of wall resistivity. Several consequences and new developments are derived from the general result that the global disruption force acting on the perfectly conducting wall must be exactly opposite to the similar force acting on the plasma, which is inherently small in tokamaks. This theoretical prediction is tested and confirmed here for the ITER tokamak with disruption modelled as the fast thermal quench followed by slower current quench that develops into the vertical displacement event. The plasma is simulated by the evolutionary equilibrium code CarMa0NL. One of the results is that the computed integral force on a perfectly conducting wall is zero at each instant during a disruption. This in turn highlights the importance of having good models for the plasma (in which the equilibrium constraint is explicitly imposed) and for the structures (able to correctly describe the induced currents and the resistive effects). The dependence of the disruption force on the magnetic field penetration through the wall is demonstrated. Also the concept of a disruption force damper is proposed, able to ‘absorb’ a significant part of the force that would arise on a resistive wall during a disruption.

  17. Sleep disruption among cancer patients following autologous hematopoietic cell transplantation.

    Science.gov (United States)

    Nelson, Ashley M; Jim, Heather S L; Small, Brent J; Nishihori, Taiga; Gonzalez, Brian D; Cessna, Julie M; Hyland, Kelly A; Rumble, Meredith E; Jacobsen, Paul B

    2018-03-01

    Despite a high prevalence of sleep disruption among hematopoietic cell transplant (HCT) recipients, relatively little research has investigated its relationships with modifiable cognitive or behavioral factors or used actigraphy to characterize sleep disruption in this population. Autologous HCT recipients who were 6-18 months post transplant completed self-report measures of cancer-related distress, fear of cancer recurrence, dysfunctional sleep cognitions, and inhibitory sleep behaviors upon enrollment. Patients then wore an actigraph for 7 days and completed a self-report measure of sleep disruption on day 7 of the study. Among the 84 participants (age M = 60, 45% female), 41% reported clinically relevant sleep disruption. Examination of actigraph data confirmed that, on average, sleep was disrupted (wake after sleep onset M = 66 min) and sleep efficiency was less than recommended (sleep efficiency M = 78%). Cancer-related distress, fear of recurrence, dysfunctional sleep cognitions, and inhibitory sleep behaviors were related to self-reported sleep disruption (p valuesdisruption after transplant. Cancer-related distress, fear of recurrence, dysfunctional sleep cognitions, and maladaptive sleep behaviors are related to self-reported sleep disruption and should be considered targets for cognitive behavioral intervention in this population.

  18. Designing reliable supply chain network with disruption risk

    Directory of Open Access Journals (Sweden)

    Ali Bozorgi Amiri

    2013-01-01

    Full Text Available Although supply chains disruptions rarely occur, their negative effects are prolonged and severe. In this paper, we propose a reliable capacitated supply chain network design (RSCND model by considering random disruptions in both distribution centers and suppliers. The proposed model determines the optimal location of distribution centers (DC with the highest reliability, the best plan to assign customers to opened DCs and assigns opened DCs to suitable suppliers with lowest transportation cost. In this study, random disruption occurs at the location, capacity of the distribution centers (DCs and suppliers. It is assumed that a disrupted DC and a disrupted supplier may lose a portion of their capacities, and the rest of the disrupted DC's demand can be supplied by other DCs. In addition, we consider shortage in DCs, which can occur in either normal or disruption conditions and DCs, can support each other in such circumstances. Unlike other studies in the extent of literature, we use new approach to model the reliability of DCs; we consider a range of reliability instead of using binary variables. In order to solve the proposed model for real-world instances, a Non-dominated Sorting Genetic Algorithm-II (NSGA-II is applied. Preliminary results of testing the proposed model of this paper on several problems with different sizes provide seem to be promising.

  19. Erosion of melt layers developed during a plasma disruption

    International Nuclear Information System (INIS)

    Hassanein, A.; Konkashbaev, A.; Konkashbaev, I.

    1995-01-01

    Material erosion of plasma-facing components during a tokamak disruption is a serious problem that limits reactor operation and economical reactor lifetime. In particular, metallic low-Z components such as Be will be subjected to severe melting during disruptions and edge localized modes (ELMs). Loss of the developed melt layer will critically shorten the lifetime of these components, severely contaminate the plasma, and seriously inhibit successful and reliable operation of the reactor. In this study mechanisms responsible for melt-layer loss during a disruption are modeled and evaluated. Implications of melt-layer loss on the performance of metallic facing components in the reactor environment are discussed. (orig.)

  20. Disruptive behaviour in the Foundation Phase of schooling

    Directory of Open Access Journals (Sweden)

    Petro Marais

    2010-01-01

    Full Text Available Since the passage of legislation banning corporal punishment in South African schools, disruptive behaviour in schools has become an issue of national concern. Against this background a research project was undertaken in which the types and causes of disruptive behaviour occurring most frequently in the Foundation Phase of schooling were identified, with a view to providing strategies for teachers to manage behaviour of this kind. A qualitative research approach was applied. Data collection was done by conducting interviews comprising semistructured questions with Foundation Phase teachers. Strategies purposely devised to deal specifically with the identified types and causes of disruptive behaviour are explained.

  1. Making CVE Work: A Focused Approach Based on Process Disruption

    Directory of Open Access Journals (Sweden)

    J.M. Berger

    2016-05-01

    Full Text Available One of the biggest barriers to designing a comprehensive Countering Violent Extremism (CVE programme is defining its scope. This paper argues for a narrow approach, focusing on disengagement and the disruption of recruitment. The author develops a simplified model of radicalisation and the concurrent terrorist recruitment process, proposing concrete themes for disruptive intervention and messaging. After analysing case studies of disengagement, the author offers recommendations for specific action to accomplish CVE goals by disrupting recruitment processes and deploying targeted messaging within the framework of the correlated models.

  2. Sleep Deprivation and Circadian Disruption: Stress, Allostasis, and Allostatic Load.

    Science.gov (United States)

    McEwen, Bruce S; Karatsoreos, Ilia N

    2015-03-01

    Sleep has important homeostatic functions, and circadian rhythms organize physiology and behavior on a daily basis to insure optimal function. Sleep deprivation and circadian disruption can be stressors, enhancers of other stressors that have consequences for the brain and many body systems. Whether the origins of circadian disruption and sleep disruption and deprivation are from anxiety, depression, shift work, long-distance air travel, or a hectic lifestyle, there are consequences that impair brain functions and contribute to the cumulative wear and tear on body systems caused by too much stress and/or inefficient management of the systems that promote adaptation. Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Human biological monitoring of suspected endocrine-disrupting compounds

    Directory of Open Access Journals (Sweden)

    Moosa Faniband

    2014-02-01

    Full Text Available Endocrine-disrupting compounds are exogenous agents that interfere with the natural hormones of the body. Human biological monitoring is a powerful method for monitoring exposure to endocrine disrupting compounds. In this review, we describe human biological monitoring systems for different groups of endocrine disrupting compounds, polychlorinated biphenyls, brominated flame retardants, phthalates, alkylphenols, pesticides, metals, perfluronated compounds, parabens, ultraviolet filters, and organic solvents. The aspects discussed are origin to exposure, metabolism, matrices to analyse, analytical determination methods, determinants, and time trends.

  4. Criteria for endocrine disrupters: report from the Danish centre on Endocrine Disrupters (CEHOS)

    DEFF Research Database (Denmark)

    Holbech, Henrik; Bjerregaard, Poul; Hass, Ulla

    The aim of this session is to give a presentation of the report (both ENV and HH) on criteria carried out by the Danish Centre on Endocrine Disrupters (CEHOS) as a project contracted by the Danish Environmental Protection Agency. CEHOS is an interdisciplinary scientific network without walls and ...... and gives examples of available ED data and relevant placement in groups. The overall purpose of the report is to provide scientific background for Danish input to the ongoing EU work within this field....... and the main purpose of the Centre is to build and gather new knowledge on endocrine disrupters (EDs) with focus on information needed for the preventive work of the regulatory authorities. The aim of the report was to propose scientific criteria for the identification of ED substances of concern for human...... health and the environment. A number of issues relevant for the development of criteria for EDs were considered such as definition, potency, lead effects, specificity and relevance for humans and the environment. The proposed criteria divide substances into three categories dependent on the available...

  5. Tebuconazole disrupts steroidogenesis in Xenopus laevis.

    Science.gov (United States)

    Poulsen, Rikke; Luong, Xuan; Hansen, Martin; Styrishave, Bjarne; Hayes, Tyrone

    2015-11-01

    A 27-day controlled exposure study of adult male African clawed frogs (Xenopus laevis) was conducted to examine the mechanism by which tebuconazole may disrupt steroidogenesis. The fungicide was measured by LC-MS/MS in tank water and in target tissues (adipose, kidney, liver, and brain), and we observed tissue-specific bioconcentration with BCF up to 238. Up to 10 different steroid hormones were quantified in gonads using LC-MS/MS and in plasma using GC-MS/MS and a radioimmunoassay was performed for further measurement of androgens. In order to assess whether effects increased with exposure or animals adapted to the xenobiotic, blood samples were collected 12 days into the study and at termination (day 27). After 12 days of exposure to 100 and 500μgL(-1) tebuconazole, plasma levels of testosterone (T) and dihydrotestosterone (DHT) were increased, while plasma 17β-estradiol (E2) concentrations were greatly reduced. Exposure to 0.1μgL(-1), on the other hand, resulted in decreased levels of T and DHT, with no effects observed for E2. After 27 days of exposure, effects were no longer observed in circulating androgen levels while the suppressive effect on E2 persisted in the two high-exposure groups (100 and 500μgL(-1)). Furthermore, tebuconazole increased gonadal concentrations of T and DHT as well as expression of the enzyme CYP17 (500μgL(-1), 27 days). These results suggest that tebuconazole exposure may supress the action of CYP17 at the lowest exposure (0.1μgL(-1)), while CYP19 suppression dominates at higher exposure concentrations (increased androgens and decreased E2). Increased androgen levels in plasma half-way into the study and in gonads at termination may thus be explained by compensatory mechanisms, mediated through increased enzymatic expression, as prolonged exposure had no effect on circulating androgen levels. Copyright © 2015. Published by Elsevier B.V.

  6. Recollecting positive and negative autobiographical memories disrupts working memory.

    Science.gov (United States)

    Allen, Richard J; Schaefer, Alexandre; Falcon, Thomas

    2014-09-01

    The present article reports two experiments examining the impact of recollecting emotionally valenced autobiographical memories on subsequent working memory (WM) task performance. Experiment 1 found that negatively valenced recollection significantly disrupted performance on a supra-span spatial WM task. Experiment 2 replicated and extended these findings to a verbal WM task (digit recall), and found that both negative and positive autobiographical recollections had a detrimental effect on verbal WM. In addition, we observed that these disruptive effects were more apparent on early trials, immediately following autobiographical recollection. Overall, these findings show that both positive and negative affect can disrupt WM when the mood-eliciting context is based on autobiographical memories. Furthermore, these results indicate that the emotional disruption of WM can take place across different modalities of WM (verbal and visuo-spatial). Copyright © 2014 Elsevier B.V. All rights reserved.

  7. Towards A Research Agenda on Digital Platform Disruption

    DEFF Research Database (Denmark)

    Kazan, Erol; Tan, Chee-Wee; Lim, Eric T. K.

    Digital platforms are disruptive IT artifacts, because they facilitate the quick release of innovative platform derivatives from third parties. This study endeavors to unravel the disruptive potential, caused by distinct designs and configurations of digital platforms on market environments. We...... postulate that the disruptive potential of digital platforms is determined by the degree of alignment among the business, technology and platform profiles. Furthermore, we argue that the design and configuration of the aforementioned three elements dictates the extent to which open innovation is permitted....... To shed light on the disruptive potential of digital platforms, we opted for digital payment platforms as our unit of analysis. Through interviews with experts and payment providers, we seek to gain an in-depth appreciation of how contemporary digital payment platforms are designed and configured...

  8. Characterization of disruptions in the Microwave Tokamak Experiment, MTX

    International Nuclear Information System (INIS)

    Hooper, E.B.; Makowski, M.A.

    1990-01-01

    The Microwave Tokamak Experiment (MTX) has a substantial number of fast diagnostics, especially for electrons, as part of its mission for pulsed, high-power electron cyclotron heating. As part of its contribution to ITER R ampersand D, these diagnostics are being used to characterize disruptions in MTX. This report is the first of two, with the second planned for submittal in September 1990, at the end of the ITER conceptual design activity. Here, we analyze the characteristics of disruptions during normal operation of MTX, discuss some new data pertaining to the ''Granetz limit,'' and describe preliminary data on ramped density shorts which will be used for fast measurements on density limit disruptions. The final report will discuss measurements using the fast diagnostics to characterize the disruption

  9. Accelerating bridge construction to minimize traffic disruption : research spotlight.

    Science.gov (United States)

    2013-12-01

    Since 2008, MDOT has been using accelerated bridge construction, which utilizes prefabricated components and structural placements, to minimize traffic disruptions during bridge replacement or rehabilitation. A recent project provided MDOT with a new...

  10. Cost Consequences of a Port-Related Supply Chain Disruption

    Directory of Open Access Journals (Sweden)

    Hui Shan LOH

    2015-09-01

    Full Text Available Port functionality is a significant and important aspect of cargo transportation. Previous studies have identified a list of port-related supply chain disruption threats and developed a management model that seeks to address these threats. This paper adds value to these related studies by comparing four consequences of an example of these threats: (1 avoidance of disruption, (2 mitigation of disruption, (3 deviation of transportation plan and (4 delays and deviation of transportation plan. The impact of these consequences is simulated in a case study using data from a chemical manufacturer based in Singapore. This paper quantitatively measures the impact of a port-related threat on supply chains and thus highlights the importance of port-related supply chain disruption management.

  11. Science and Technology Test Mining: Disruptive Technology Roadmaps

    National Research Council Canada - National Science Library

    Kostoff, Ronald

    2003-01-01

    Disruptive technologies create growth in the industries they penetrate or create entirely new industries through the introduction of products and services that are dramatically cheaper, better, and more convenient...

  12. Disruption management for truck appointment system at a container terminal

    DEFF Research Database (Denmark)

    Li, Na; Chen, Gang; Govindan, Kannan

    2018-01-01

    Disruption often occurs in both land-side and sea-side operations at a container terminal, causing substantial interference of scheduled operations and poor green performance. The land-side disruption is rarely researched, and this paper addresses the ordinary level of such disruption where......-appointed arrivals at a container terminal that is running an appointment system. Second, we propose some response strategies to cope with different levels of disruptions, and evaluate their resilience ability with two Key Performance Indicators (KPIs): total waiting time of on-time trucks and total idling emissions...... scenarios is a combined one based on priority and yard-crane moving distance; its performance depends primarily on the concentration level of container locations and secondly on the system utilization. In the other scenarios that have low arrival punctuality, the best strategy could focus purely on yard...

  13. A System Shock Approach to Modelling Clandestine Network Disruption

    National Research Council Canada - National Science Library

    Dipper, Tamlan

    2004-01-01

    .... This model took as its focus the disruption of successful terrorist operations. In doing so it drew upon operational art, group behavioural studies, and psychological research into problem solving...

  14. Magnetohydrodynamic simulations of density-limit disruptions in tokamaks

    International Nuclear Information System (INIS)

    Kleva, R.G.; Drake, J.F.; Denton, R.E.

    1990-01-01

    Magnetohydrodynamic simulations are presented which demonstrate that density limit disruptions can be triggered by edge radiation which destabilizes a q = 1 kink followed by a q = 2 tearing mode. A bubble of cold plasma is injected from the edge into the center by the q = 1 kink. The q = 2 mode then broadens the current profile and throws the hot plasma to the wall. The MHD simulations presented are the first to successfully reproduce several key features of density limit disruptions including (1) the rapid drop in the central temperature, (2) the rapid expansion of the current profile, (3) the m = 1 cold bubble which is seen to be injected from the edge into the center during density limit disruptions on JET, and (4) disruptions in sawtoothing discharges. (author)

  15. Simulating Impacts of Disruptions to Liquid Fuels Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Wilson, Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Resilience and Regulatory Effects; Corbet, Thomas F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Policy and Decision Analytics; Baker, Arnold B. [ABB Consulting, Albuquerque, NM (United States); O' Rourke, Julia M. [Univ. of Texas, Austin, TX (United States). Dept. of Mechanical Engineering

    2015-04-01

    This report presents a methodology for estimating the impacts of events that damage or disrupt liquid fuels infrastructure. The impact of a disruption depends on which components of the infrastructure are damaged, the time required for repairs, and the position of the disrupted components in the fuels supply network. Impacts are estimated for seven stressing events in regions of the United States, which were selected to represent a range of disruption types. For most of these events the analysis is carried out using the National Transportation Fuels Model (NTFM) to simulate the system-level liquid fuels sector response. Results are presented for each event, and a brief cross comparison of event simulation results is provided.

  16. Short- and long-term health consequences of sleep disruption

    Directory of Open Access Journals (Sweden)

    Medic G

    2017-05-01

    Full Text Available Goran Medic,1,2 Micheline Wille,1 Michiel EH Hemels1 1Market Access, Horizon Pharma B.V., Utrecht, 2Unit of Pharmacoepidemiology & Pharmacoeconomics, Department of Pharmacy, University of Groningen, Groningen, The Netherlands Abstract: Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short- and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep. Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic–pituitary–adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with

  17. Who disrupts from placement in foster and kinship care?

    Science.gov (United States)

    Chamberlain, Patricia; Price, Joe M; Reid, John B; Landsverk, John; Fisher, Phillip A; Stoolmiller, Mike

    2006-04-01

    To identify reliable, inexpensive predictors of foster care placement disruption that could be used to assess risk of placement failure. Using the Parent Daily Report Checklist (PDR), foster or kinship parents of 246 children (5-12 years old) in California were interviewed three times about whether or not their foster child engaged in any of the 30 problem behaviors during the previous 24 h. PDR was conducted during telephone contacts (5-10 min each) that occurred from 1 to 3 days apart at baseline. Disruptions were tracked for the subsequent 12 months. Other potential predictors of disruption were examined, including the child's age, gender, and ethnicity, the foster parent's ethnicity, the number of other children in the foster home, and the type of placement (kin or non-kin). Foster/kin parents reported an average of 5.77 child problems per day on the PDR checklist. The number of problem behaviors was linearly related to the child's risk of placement disruption during the subsequent year. The threshold for the number of problem behaviors per day that foster and kinship parents tolerated without increased risk of placement disruption for these latency-aged children was 6 or fewer. Children in non-kin placements were more likely to disrupt than those in kinship placements. There was a trend for increased risk of disruption as the number of children in the home increased. The PDR Checklist may be useful in predicting which placements are at most risk of future disruption, allowing for targeted services and supports.

  18. Dynamic communications for small satellites using disruption tolerant network concepts

    OpenAIRE

    Giuditta, N.; Gill, E.K.A.; Fernández, B.; Isaac, D.

    2009-01-01

    New network technologies are providing interconnectivity in areas previously unheard of. One of these novel technologies, named Disruption Tolerant Networking (DTN), shows promise for the space industry. In order to study its suitability for University projects, a model of a University space mission has been created using network simulation software. This offers an insight into the characteristics, opportunities and challenges of this new technology. Disruption Tolerant Networking is a pionee...

  19. North Sea submarine cable disruptions and fishing activity

    OpenAIRE

    Hintzen, N.T.; Machiels, M.A.M.

    2014-01-01

    At the North Sea seafloor, numerous submarine cables are positioned that connect telecommunication networks between countries. Worldwide, human activities cause most of the cable disruptions with fisheries accounting for nearly half of all reported faults. Due to a recent increase of submarine cable disruptions in the central North Sea area, Global Marine Systems Ltd. requested IMARES to investigate a possible link between these occurrences and the recent gear switch of the Dutch –demersal be...

  20. Total magnetic reconnection during a tokamak major disruption

    International Nuclear Information System (INIS)

    Goetz, J.A.; Dexter, R.N.; Prager, S.C.

    1990-07-01

    The safety factor within a tokamak plasma has been measured during a major disruption. During the disruption, the central safety factor jumps from below one to above one, while the total current is unchanged. This implies that total reconnection has occurred. This observation is in contract to the absence of total reconnection observed during a sawtooth oscillation in the same device. 11 refs., 6 figs

  1. Science and Technology Test Mining: Disruptive Technology Roadmaps

    Science.gov (United States)

    2003-07-23

    2330, 2002. This paper discusses how peer-to-peer computing is emerging as a disruptive technology for global collaborative solutions. It explains how...8217brand image’ of nation-states on a global plane. The article critiques the notion that new media, especially the internet, are disruptive technologies ...advantage over potential adversaries. The widespread access to a wide variety of modern top of the fine technologies made possible by the globalization of

  2. A theoretical method for assessing disruptive computer viruses

    Science.gov (United States)

    Wu, Yingbo; Li, Pengdeng; Yang, Lu-Xing; Yang, Xiaofan; Tang, Yuan Yan

    2017-09-01

    To assess the prevalence of disruptive computer viruses in the situation that every node in a network has its own virus-related attributes, a heterogeneous epidemic model is proposed. A criterion for the global stability of the virus-free equilibrium and a criterion for the existence of a unique viral equilibrium are given, respectively. Furthermore, extensive simulation experiments are conducted, and some interesting phenomena are found from the experimental results. On this basis, some policies of suppressing disruptive viruses are recommended.

  3. Managing Port-Related Supply Chain Disruptions: A Conceptual Paper

    Directory of Open Access Journals (Sweden)

    Hui Shan Loh

    2014-04-01

    This paper synthesizes the current literature into a management model that seeks to target operational deficiencies at ports. The management model is operationalized in three tiers, from the top management level to the front-line employees, with characteristics from risk management, business continuity management and quality management theories. The proposed model serves as a universal guide in assisting port management in managing port-related disruptions and seeks to reduce the occurrences of port-related supply chain disruption threats.

  4. MHD precursor to disruption in Iran tokamak 1

    International Nuclear Information System (INIS)

    Alireza, Hojabri; Fatemeh, Hajakbari; Alireza, Hojabri; Mahmmod, Ghoranneviss; Fatemeh, Hajakbari

    2004-01-01

    The purpose of this paper is to investigate the major disruptions occurring in low-q(a) discharges in Iran Tokamak 1, and to compare the theoretical and experimental results for the rate of island growth. The study of precursor phase of disruption can be predicted and avoided using suitable control systems. In this paper are described the stability analysis and the observed growth rates indicating that the rotating modes are tearing modes. (authors)

  5. "Targeted disruption of the epithelial-barrier by Helicobacter pylori"

    Directory of Open Access Journals (Sweden)

    Wroblewski Lydia E

    2011-11-01

    Full Text Available Abstract Helicobacter pylori colonizes the human gastric epithelium and induces chronic gastritis, which can lead to gastric cancer. Through cell-cell contacts the gastric epithelium forms a barrier to protect underlying tissue from pathogenic bacteria; however, H. pylori have evolved numerous strategies to perturb the integrity of the gastric barrier. In this review, we summarize recent research into the mechanisms through which H. pylori disrupts intercellular junctions and disrupts the gastric epithelial barrier.

  6. Light pollution disrupts sleep in free-living animals

    OpenAIRE

    Raap, Thomas; Pinxten, Rianne; Eens, Marcel

    2015-01-01

    Artificial lighting can alter individual behaviour, with often drastic and potentially negative effects on biological rhythms, daily activity and reproduction. Whether this is caused by a disruption of sleep, an important widespread behaviour enabling animals to recover from daily stress, is unclear. We tested the hypothesis that light pollution disrupts sleep by recording individual sleep behaviour of great tits, Parus major, that were roosting in dark nest-boxes and were exposed to light-em...

  7. MOOCs as a disruptive force in online education

    Directory of Open Access Journals (Sweden)

    Dennis Viehland

    Full Text Available MOOCs - massive open online courses - have emerged as the dominant topic in online education in New Zealand and elsewhere. MOOCs have been variously described as a tsunami, a paradigm shift and a disruptive force to both place-based and online tertiary education. This paper offers a comprehensive description of MOOCs and discusses key disruptive aspects of MOOC-based education such as university/student disengagement, low completion rates, peer assessment and business models.

  8. Tumor RNA disruption predicts survival benefit from breast cancer chemotherapy.

    Science.gov (United States)

    Parissenti, Amadeo M; Guo, Baoqing; Pritzker, Laura B; Pritzker, Kenneth P H; Wang, Xiaohui; Zhu, Mu; Shepherd, Lois E; Trudeau, Maureen E

    2015-08-01

    In a prior substudy of the CAN-NCIC-MA.22 clinical trial (ClinicalTrials.gov identifier NCT00066443), we observed that neoadjuvant chemotherapy reduced tumor RNA integrity in breast cancer patients, a phenomenon we term "RNA disruption." The purpose of the current study was to assess in the full patient cohort the relationship between mid-treatment tumor RNA disruption and both pCR post-treatment and, subsequently, disease-free survival (DFS) up to 108 months post-treatment. To meet these objectives, we developed the RNA disruption assay (RDA) to quantify RNA disruption and stratify it into 3 response zones of clinical importance. Zone 1 is a level of RNA disruption inadequate for pathologic complete response (pCR); Zone 2 is an intermediate level, while Zone 3 has high RNA disruption. The same RNA disruption cut points developed for pCR response were then utilized for DFS. Tumor RDA identified >fourfold more chemotherapy non-responders than did clinical response by calipers. pCR responders were clustered in RDA Zone 3, irrespective of tumor subtype. DFS was about 2-fold greater for patients with tumors in Zone 3 compared to Zone 1 patients. Kaplan-Meier survival curves corroborated these findings that high tumor RNA disruption was associated with increased DFS. DFS values for patients in zone 3 that did not achieve a pCR were similar to that of pCR recipients across tumor subtypes, including patients with hormone receptor positive tumors that seldom achieve a pCR. RDA appears superior to pCR as a chemotherapy response biomarker, supporting the prospect of its use in response-guided chemotherapy.

  9. Transport-diffusion comparisons for small core LMFBR disruptive accidents

    International Nuclear Information System (INIS)

    Tomlinson, E.T.

    1977-11-01

    A number of numerical experiments were performed to assess the validity of diffusion theory for calculating the reactivity state of various small core LMFBR disrupted geometries. The disrupted configurations correspond, in general, to various configurations predicted by SAS3A for transient undercooling (TUC) and transient overpower (TOP) accidents for homogeneous cores and to the ZPPR-7 configurations for heterogeneous core. In all TUC cases diffusion theory was shown to be inadequate for the calculation of reactivity changes during core disassembly

  10. Symbiotic Gene Activation is Interrupted by Endocrine Disrupting Chemicals

    OpenAIRE

    Jennifer E. Fox; Matthew E. Burow; John A. McLachlan

    2001-01-01

    Endocrine disrupting chemicals (EDCs) include organochlorine pesticides, plastics manufacturing by-products, and certain herbicides[1]. These chemicals have been shown to disrupt hormonal signaling in exposed wildlife, lab animals, and mammalian cell culture by binding to estrogen receptors (ER-α and ER-β) and affecting the expression of estrogen responsive genes[2,3]. Additionally, certain plant chemicals, termed phytoestrogens, are also able to bind to estrogen receptors and modulate gene e...

  11. Supply Disruptions, Asymmetric Information, and a Backup Production Option

    OpenAIRE

    Zhibin (Ben) Yang; Göker Ayd{\\i}n; Volodymyr Babich; Damian R. Beil

    2009-01-01

    We study a manufacturer that faces a supplier privileged with private information about supply disruptions. We investigate how risk-management strategies of the manufacturer change and examine whether risk-management tools are more or less valuable in the presence of such asymmetric information. We model a supply chain with one manufacturer and one supplier, in which the supplier's reliability is either high or low and is the supplier's private information. On disruption, the supplier chooses...

  12. Mutualism Disruption Threatens Global Plant Biodiversity: A Systematic Review.

    Directory of Open Access Journals (Sweden)

    Clare E Aslan

    Full Text Available As global environmental change accelerates, biodiversity losses can disrupt interspecific interactions. Extinctions of mutualist partners can create "widow" species, which may face reduced ecological fitness. Hypothetically, such mutualism disruptions could have cascading effects on biodiversity by causing additional species coextinctions. However, the scope of this problem - the magnitude of biodiversity that may lose mutualist partners and the consequences of these losses - remains unknown.We conducted a systematic review and synthesis of data from a broad range of sources to estimate the threat posed by vertebrate extinctions to the global biodiversity of vertebrate-dispersed and -pollinated plants. Though enormous research gaps persist, our analysis identified Africa, Asia, the Caribbean, and global oceanic islands as geographic regions at particular risk of disruption of these mutualisms; within these regions, percentages of plant species likely affected range from 2.1-4.5%. Widowed plants are likely to experience reproductive declines of 40-58%, potentially threatening their persistence in the context of other global change stresses.Our systematic approach demonstrates that thousands of species may be impacted by disruption in one class of mutualisms, but extinctions will likely disrupt other mutualisms, as well. Although uncertainty is high, there is evidence that mutualism disruption directly threatens significant biodiversity in some geographic regions. Conservation measures with explicit focus on mutualistic functions could be necessary to bolster populations of widowed species and maintain ecosystem functions.

  13. Disruption of dark matter substructure: fact or fiction?

    Science.gov (United States)

    van den Bosch, Frank C.; Ogiya, Go; Hahn, Oliver; Burkert, Andreas

    2018-03-01

    Accurately predicting the demographics of dark matter (DM) substructure is of paramount importance for many fields of astrophysics, including gravitational lensing, galaxy evolution, halo occupation modelling, and constraining the nature of DM. Because of its strongly non-linear nature, DM substructure is typically modelled using N-body simulations, which reveal that large fractions of DM subhaloes undergo complete disruption. In this paper, we use both analytical estimates and idealized numerical simulations to investigate whether this disruption is mainly physical, due to tidal heating and stripping, or numerical (i.e. artificial). We show that, contrary to naive expectation, subhaloes that experience a tidal shock ΔE that exceeds the subhalo's binding energy, |Eb|, do not undergo disruption, even when ΔE/|Eb| is as large as 100. Along the same line, and contrary to existing claims in the literature, instantaneously stripping matter from the outskirts of a DM subhalo also does not result in its complete disruption, even when the instantaneous remnant has positive binding energy. In addition, we show that tidal heating due to high-speed (impulsive) encounters with other subhaloes (`harassment') is negligible compared to the tidal effects due to the host halo. Hence, we conclude that, in the absence of baryonic processes, the complete physical disruption of CDM substructure is extremely rare and that most disruption in numerical simulations therefore must be artificial. We discuss various processes that have been associated with numerical overmerging and conclude that inadequate force softening is the most likely culprit.

  14. Ultraviolet and optical observations of tidal disruption events

    Directory of Open Access Journals (Sweden)

    Gezari S.

    2012-12-01

    Full Text Available Tidal disruption events are expected to produce a luminous flare of radiation from fallback accretion of tidally disrupted stellar debris onto the central supermassive black hole. The first convincing candidates for tidal disruption events were discovered in the soft X-rays: large-amplitude, luminous, extremely-soft X-ray flares from inactive galaxies in the ROSAT All-Sky survey. However, the sparsely sampled light curves and lack of multiwavelength observations for these candidates make it difficult to directly constrain the parameters of their events (e.g., Eddington ratio, mass of the black hole, type of star disrupted. Here I present a review of the recent progress made in studying tidal disruption events in detail from taking advantage of wide-field, multi-epoch observations of UV and optical surveys (GALEX, SDSS, PTF, Pan-STARRS1 to measure well-sampled light curves, trigger prompt multiwavelength follow-up observations, and measure rates. I conclude with the promising potential of the next generation of optical synoptic surveys, such as LSST, to probe black hole demographics with samples of thousands of tidal disruption events.

  15. Emotions, cognitive interference, and concentration disruption in youth sport.

    Science.gov (United States)

    McCarthy, Paul J; Allen, Mark S; Jones, Marc V

    2013-01-01

    We explored the relationship between emotions, cognitive interference, concentration disruption and performance in youth sport. In study 1, 150 youth sport athletes (Mage = 13.13 years, s = 1.79) completed measures of emotion, cognitive interference, and concentration disruption for their most recently completed competition. In Study 2, 46 female rhythmic gymnasts (Mage = 10.30 years, s = 1.74) completed measures of emotion immediately before competition, and measures of cognitive interference and concentration disruption immediately after competition. Study 1 showed that anxiety and dejection were associated with more interfering thoughts and greater disruptions in concentration, whereas the effects of anger and happiness on interfering thoughts differed relative to the age of participants. Specifically, anger was associated with more interfering thoughts only in younger athletes and happiness was associated with fewer interfering thoughts only in older athletes. Study 2 showed that emotions experienced before competition were not strongly associated with cognitive interference or concentration disruption, but athletes reporting more thoughts of escape in competition were less successful in the competition as measured by objective performance scores. These findings demonstrate that emotions are important for cognitive interference and concentration disruption, and provide some initial evidence that cognitive interference is important for performance in youth sport.

  16. Aggregate formation affects ultrasonic disruption of microalgal cells.

    Science.gov (United States)

    Wang, Wei; Lee, Duu-Jong; Lai, Juin-Yih

    2015-12-01

    Ultrasonication is a cell disruption process of low energy efficiency. This study dosed K(+), Ca(2+) and Al(3+) to Chlorella vulgaris cultured in Bold's Basal Medium at 25°C and measured the degree of cell disruption under ultrasonication. Adding these metal ions yielded less negatively charged surfaces of cells, while with the latter two ions large and compact cell aggregates were formed. The degree of cell disruption followed: control=K(+)>Ca(2+)>Al(3+) samples. Surface charges of cells and microbubbles have minimal effects on the microbubble number in the proximity of the microalgal cells. Conversely, cell aggregates with large size and compact interior resist cell disruption under ultrasonication. Staining tests revealed high diffusional resistance of stains over the aggregate interior. Microbubbles may not be effective generated and collapsed inside the compact aggregates, hence leading to low cell disruption efficiencies. Effective coagulation/flocculation in cell harvesting may lead to adverse effect on subsequent cell disruption efficiency. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Disruptive Event Biosphere Dose Conversion Factor Analysis

    International Nuclear Information System (INIS)

    M. A. Wasiolek

    2003-01-01

    This analysis report, ''Disruptive Event Biosphere Dose Conversion Factor Analysis'', is one of the technical reports containing documentation of the ERMYN (Environmental Radiation Model for Yucca Mountain Nevada) biosphere model for the geologic repository at Yucca Mountain, its input parameters, and the application of the model to perform the dose assessment for the repository. The biosphere model is one of a series of process models supporting the Total System Performance Assessment (TSPA) for the Yucca Mountain repository. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of the two reports that develop biosphere dose conversion factors (BDCFs), which are input parameters for the TSPA model. The ''Biosphere Model Report'' (BSC 2003 [DIRS 164186]) describes in detail the conceptual model as well as the mathematical model and lists its input parameters. Model input parameters are developed and described in detail in five analysis report (BSC 2003 [DIRS 160964], BSC 2003 [DIRS 160965], BSC 2003 [DIRS 160976], BSC 2003 [DIRS 161239], and BSC 2003 [DIRS 161241]). The objective of this analysis was to develop the BDCFs for the volcanic ash exposure scenario and the dose factors (DFs) for calculating inhalation doses during volcanic eruption (eruption phase of the volcanic event). The volcanic ash exposure scenario is hereafter referred to as the volcanic ash scenario. For the volcanic ash scenario, the mode of radionuclide release into the biosphere is a volcanic eruption through the repository with the resulting entrainment of contaminated waste in the tephra and the subsequent atmospheric transport and dispersion of contaminated material in the biosphere. The biosphere process

  18. Disruptive Event Biosphere Dose Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. A. Wasiolek

    2003-07-21

    This analysis report, ''Disruptive Event Biosphere Dose Conversion Factor Analysis'', is one of the technical reports containing documentation of the ERMYN (Environmental Radiation Model for Yucca Mountain Nevada) biosphere model for the geologic repository at Yucca Mountain, its input parameters, and the application of the model to perform the dose assessment for the repository. The biosphere model is one of a series of process models supporting the Total System Performance Assessment (TSPA) for the Yucca Mountain repository. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of the two reports that develop biosphere dose conversion factors (BDCFs), which are input parameters for the TSPA model. The ''Biosphere Model Report'' (BSC 2003 [DIRS 164186]) describes in detail the conceptual model as well as the mathematical model and lists its input parameters. Model input parameters are developed and described in detail in five analysis report (BSC 2003 [DIRS 160964], BSC 2003 [DIRS 160965], BSC 2003 [DIRS 160976], BSC 2003 [DIRS 161239], and BSC 2003 [DIRS 161241]). The objective of this analysis was to develop the BDCFs for the volcanic ash exposure scenario and the dose factors (DFs) for calculating inhalation doses during volcanic eruption (eruption phase of the volcanic event). The volcanic ash exposure scenario is hereafter referred to as the volcanic ash scenario. For the volcanic ash scenario, the mode of radionuclide release into the biosphere is a volcanic eruption through the repository with the resulting entrainment of contaminated waste in the tephra and the subsequent atmospheric transport and dispersion of contaminated material in

  19. Disruptive behaviour in the perioperative setting: a contemporary review.

    Science.gov (United States)

    Villafranca, Alexander; Hamlin, Colin; Enns, Stephanie; Jacobsohn, Eric

    2017-02-01

    Disruptive behaviour, which we define as behaviour that does not show others an adequate level of respect and causes victims or witnesses to feel threatened, is a concern in the operating room. This review summarizes the current literature on disruptive behaviour as it applies to the perioperative domain. Searches of MEDLINE ® , Scopus™, and Google books identified articles and monographs of interest, with backreferencing used as a supplemental strategy. Much of the data comes from studies outside the operating room and has significant methodological limitations. Disruptive behaviour has intrapersonal, interpersonal, and organizational causes. While fewer than 10% of clinicians display disruptive behaviour, up to 98% of clinicians report witnessing disruptive behaviour in the last year, 70% report being treated with incivility, and 36% report being bullied. This type of conduct can have many negative ramifications for clinicians, students, and institutions. Although the evidence regarding patient outcomes is primarily based on clinician perceptions, anecdotes, and expert opinion, this evidence supports the contention of an increase in morbidity and mortality. The plausible mechanism for this increase is social undermining of teamwork, communication, clinical decision-making, and technical performance. The behavioural responses of those who are exposed to such conduct can positively or adversely moderate the consequences of disruptive behaviour. All operating room professions are involved, with the rank order (from high to low) being surgeons, nurses, anesthesiologists, and "others". The optimal approaches to the prevention and management of disruptive behaviour are uncertain, but they include preventative and professional development courses, training in soft skills and teamwork, institutional efforts to optimize the workplace, clinician contracts outlining the clinician's (and institution's) responsibilities, institutional policies that are monitored and

  20. Structured Literature Review of disruptive innovation theory within the digital domain

    DEFF Research Database (Denmark)

    Vesti, Helle; Nielsen, Christian; Rosenstand, Claus Andreas Foss

    2017-01-01

    The area of interest is disruption is the digital domain. The research questions are: How has the disruption and digital disruption literature developed over time? What is the research focus into disruption regarding the digital domain and how has this changed over time?Which methods are being...... utilized in research regarding disruption and digital disruption?Where are the key contributors to disruption in general and in digital disruption? Is there a future for digital disruption research? The method is a Structured Literature Review (SLR). The contribution is the results of an analysis of 95...... publications within the field of disruption in the digital domain and disruptive innovation theory in general. Works of twelve practitioners and 83 academics are investigated....

  1. Risk factors for wound disruption following cesarean delivery.

    Science.gov (United States)

    Subramaniam, Akila; Jauk, Victoria C; Figueroa, Dana; Biggio, Joseph R; Owen, John; Tita, Alan T N

    2014-08-01

    Risk factors for post-cesarean wound infection, but not disruption, are well-described in the literature. The primary objective of this study was to identify risk factors for non-infectious post-cesarean wound disruption. Secondary analysis was conducted using data from a single-center randomized controlled trial of staple versus suture skin closure in women ≥24 weeks' gestation undergoing cesarean delivery. Wound disruption was defined as subcutaneous skin or fascial dehiscence excluding primary wound infections. Composite wound morbidity (disruption or infection) was examined as a secondary outcome. Patient demographics, medical co-morbidities, and intrapartum characteristics were evaluated as potential risk factors using multivariable logistic regression. Of the 398 randomized patients, 340, including 26 with disruptions (7.6%) met inclusion criteria and were analyzed. After multivariable adjustments, African-American race (aOR 3.9, 95% CI 1.1-13.8) and staple - as opposed to suture - wound closure (aOR 5.4, 95% CI 1.8-16.1) remained significant risk factors for disruption; non-significant increases were observed for body mass index ≥30 (aOR 2.1, 95% CI 0.6-7.5), but not for diabetes mellitus (aOR 0.9, 95% CI 0.3-2.9). RESULTS for composite wound morbidity were similar. Skin closure with staples, African-American race, and considering the relatively small sample size, potentially obesity are associated with increased risk of non-infectious post-cesarean wound disruption.

  2. The Spark of Disruptive Innovation for Space Physics and Aeronomy

    Science.gov (United States)

    MacDonald, E.

    2017-12-01

    What is disruptive innovation and why does it matter for Space Physics and Aeronomy (SPA)? This presentation will define disruptive innovation and present several examples relevant to SPA. These examples range from Cubesats to Citizen Science. Disruptive innovation requires not just an idea but also execution. Why do we need disruptive innovation? Simply put, we need to break out of our comfortable rut to solve bigger problems and evolve as a field for the future. These opportunities are exciting and they are difficult. SPA is well-suited to these types of interdisciplinary applications, due to its dual fundamental and applied nature that dovetails with many other fields. Challenges are that we do not incentivize disruptive innovation, we do not recognize it, and we typically do not fund it. As a result we are risk averse and we suffer from the "Matthew effect" of accumulated advantage. We do not allow ourselves to learn from new and uncomfortable angles and recognize the innovation that comes from there. The strength of having a more diverse and inclusive field is that a range of more diverse ideas and perspectives will be promoted. The next big innovations for SPA may come from the outside, and the best way to capture such ideas may be to promote diversity and inclusion at all levels.

  3. [Vascular disruption birth defects are not associated to chromosomal alterations].

    Science.gov (United States)

    Pachajoa, Harry; Ariza, Yoseth; Isaza, Carolina; Méndez, Fabián

    2015-11-01

    It is estimated that 2 to 35 of newborns present a congenital malformation. Some publications suggest that vascular disruption birth defects are not associated with chromosomal alterations detected by conventional karyotype. to determine the frequency of chromosomal alterations detected by high resolution G banded karyotype in patients with vascular disruption birth defects in a Colombian population (South America). transversal study. Population: a sample of patients identified by an epidemiological surveillance system of congenital malformations in a reference hospital in Cali, Colombia. 41 cases of vascular disruption birth defects were identified during a 36 month period; in a descending order those were: transverse reduction defects, hydranencephaly and gastroschisis. Two expert cytogenetists performed independent evaluation of the genetic material of the patients, and no chromosomal alterations detectable by G banded karyotype were identified. It is recommended that genetic counseling in cases of defects by vascular disruption is carried out taking into account the empirical recurrence risks reported for each one the types of defects by vascular disruption and the use of karyotype should be limited to cases with other malformations or chromosomal abnormality suspected by phenotype.

  4. TMS produces two dissociable types of speech disruption.

    Science.gov (United States)

    Stewart, L; Walsh, V; Frith, U; Rothwell, J C

    2001-03-01

    We aimed to use repetitive transcranial magnetic stimulation (rTMS) to disrupt speech with the specific objective of dissociating speech disruption according to whether or not it was associated with activation of the mentalis muscle. Repetitive transcranial magnetic stimulation (rTMS) was applied over two sites of the right and left hemisphere while subjects counted aloud and recited the days of the week, months of the year, and nursery rhymes. Analysis of EMG data and videotaped recordings showed that rTMS applied over a posterior site, lateral to the motor hand area of both the right and the left hemisphere resulted in speech disruption that was accompanied by activation of the mentalis muscle, while rTMS applied over an anterior site on the left but not the right hemisphere resulted in speech disruption that was dissociated from activation of the mentalis muscle. The findings provide a basis for the use of subthreshold stimulation over the extrarolandic speech disruption site in order to probe the functional properties of this area and to test psychological theories of linguistic function. Copyright 2001 Academic Press.

  5. Parents’ Education, Personality, and Their Children’s Disruptive Behaviour

    Directory of Open Access Journals (Sweden)

    Purwati

    2017-07-01

    Full Text Available The aims of this study were (1 to understand the effects of parents' education and personality aspects on child disruptive behavior, (2 to know the correlation between the parents' personality aspects (N-Deference, N-Succorance, NDominance and N-Aggression and the children' disruptive behavior. A quantitative approach to the correlational design was employed. Three variables were studied, namely parents' education and personality as the independent variables and child disruptive behavior as the independent variable. The applied instruments are questionnaires, (2 personality test (EPPS, and (3 observation with time and interval samplings approach. The population is from Magelang, Indonesia, while the participants are 100 children at the age of 5 – 7 years and their parents. The results show that (1 there are some effects of parents' education and personality on child disruptive behavior, and (2 aggressive aspects of the parents' personality gave great effects on child disruptive behavior, followed by the succorance, deference, and at the lowest level, the dominance aspects

  6. Electrical stimulation of a small brain area reversibly disrupts consciousness.

    Science.gov (United States)

    Koubeissi, Mohamad Z; Bartolomei, Fabrice; Beltagy, Abdelrahman; Picard, Fabienne

    2014-08-01

    The neural mechanisms that underlie consciousness are not fully understood. We describe a region in the human brain where electrical stimulation reproducibly disrupted consciousness. A 54-year-old woman with intractable epilepsy underwent depth electrode implantation and electrical stimulation mapping. The electrode whose stimulation disrupted consciousness was between the left claustrum and anterior-dorsal insula. Stimulation of electrodes within 5mm did not affect consciousness. We studied the interdependencies among depth recording signals as a function of time by nonlinear regression analysis (h(2) coefficient) during stimulations that altered consciousness and stimulations of the same electrode at lower current intensities that were asymptomatic. Stimulation of the claustral electrode reproducibly resulted in a complete arrest of volitional behavior, unresponsiveness, and amnesia without negative motor symptoms or mere aphasia. The disruption of consciousness did not outlast the stimulation and occurred without any epileptiform discharges. We found a significant increase in correlation for interactions affecting medial parietal and posterior frontal channels during stimulations that disrupted consciousness compared with those that did not. Our findings suggest that the left claustrum/anterior insula is an important part of a network that subserves consciousness and that disruption of consciousness is related to increased EEG signal synchrony within frontal-parietal networks. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Total magnetic reconnection during a tokamak major disruption

    International Nuclear Information System (INIS)

    Goetz, J.A.

    1990-09-01

    Magnetic reconnection has long been considered to be the cause of sawtooth oscillations and major disruptions in tokamak experiments. Experimental confirmation of reconnection models has been hampered by the difficulty of direct measurement of reconnection, which would involve tracing field lines for many transits around the tokamak. Perhaps the most stringent test of reconnection in a tokamak involves measurement of the safety factor q. Reconnection arising from a single helical disturbance with mode numbers m and n should raise q to m/n everywhere inside of the original resonant surface. Total reconnection should also flatten the temperature and current density profiles inside of this surface. Disruptive instabilities have been studied in the Tokapole 2, a poloidal divertor tokamak. When Tokapole 2 is operated in the material limiter configuration, a major disruption results in current termination as in most tokamaks. However, when operated in the magnetic limiter configuration current termination is suppressed and major disruptions appear as giant sawtooth oscillations. The objective of this thesis is to determine if total reconnection is occurring during major disruptions. To accomplish this goal, the poloidal magnetic field has been directly measured in Tokapole 2 with internal magnetic coils. A full two-dimensional measurement over the central current channel has been done. From these measurements, the poloidal magnetic flux function is obtained and the magnetic surfaces are plotted. The flux-surface-averaged safety factor is obtained by integrating the local magnetic field line pitch over the experimentally obtained magnetic surface

  8. MANAGING DISRUPTIVE BEHAVIOR OF STUDENTS IN LANGUAGE CLASSROOM

    Directory of Open Access Journals (Sweden)

    Siti Khasinah

    2017-05-01

    Full Text Available This article describes students’ disruptive behaviors in language classroom that may greatly affect language teaching and learning process, especially in ESL or EFL classes. Teachers should know what disruptive behavior is to enable them to deal with problems occurred in their classroom or to take preventive actions to keep their students well-behaved during the class. This can reduce the occurrence of misbehavior of students in their classroom. To prevent disruption in the classroom, teachers should establish behavioral expectations in the first day of the semester and the expectations can be based on students attendance, arrivals and departures, class participation, full English speaking, and other appropriate conducts in the syllabus and discuss them at the outset of the term. The agreement is then assigned as a learning contract or a code of conducts with which bounds the whole class. Consequently, whenever students are misbehaved, teachers and other students will directly know and recognize that the behaviors are out of the code. There are factors reasoning students to behave badly, so teachers as trouble solvers have to find appropriate strategies that are effective in helping students keep the code. Otherwise, the disruptions will escalate quickly and the problems will increase in numbers rapidly and finally, teachers will have to work very hard to avoid teaching failure and “losing face” when they cannot manage the disruption as listed in the expectation.

  9. Design Disruption in Contested, Contingent and Contradictory Future-Making

    Directory of Open Access Journals (Sweden)

    Yoko Akama

    2015-10-01

    Full Text Available This paper aims to problematize how we step into situations that are often contested, contingent and contradictory. In this context, how can we sharpen our sensitivity of the role design plays in generating understanding and future-making possibilities? Here, we employ the term disruption as a way to question our own knowledge construction and research practices in Design Anthropology and Participatory Design. We pursue disruption as a political and necessary consciousness when Design Anthropology meets Participatory Design and discuss the generative, reflexive and analytical dimensions of disruption through three vignettes. These vignettes raises questions of how we interrogate disruptions of power to consider different ways in which this manifests when entering into and participating in ongoing changing process. They also highlight the need to displace existing knowledge, rather than pursuing ‘mutual learning’ that had been a defining commitment of Participatory Design. Lastly, the vignettes reveal the need to disrupt the designer-researcher in order to surrender to contradiction and contingency as part of future-making.

  10. Laboratory tests of catastrophic disruption of rotating bodies

    Science.gov (United States)

    Morris, A. J. W.; Burchell, M. J.

    2017-11-01

    The results of catastrophic disruption experiments on static and rotating targets are reported. The experiments used cement spheres of diameter 10 cm as the targets. Impacts were by mm sized stainless steel spheres at speeds of between 1 and 7.75 km s-1. Energy densities (Q) in the targets ranged from 7 to 2613 J kg-1. The experiments covered both the cratering and catastrophic disruption regimes. For static, i.e. non-rotating targets the critical energy density for disruption (Q*, the value of Q when the largest surviving target fragment has a mass equal to one half of the pre-impact target mass) was Q* = 1447 ± 90 J kg-1. For rotating targets (median rotation frequency of 3.44 Hz) we found Q* = 987 ± 349 J kg-1, a reduction of 32% in the mean value. This lower value of Q* for rotating targets was also accompanied by a larger scatter on the data, hence the greater uncertainty. We suggest that in some cases the rotating targets behaved as static targets, i.e. broke up with the same catastrophic disruption threshold, but in other cases the rotation helped the break up causing a lower catastrophic disruption threshold, hence both the lower value of Q* and the larger scatter on the data. The fragment mass distributions after impact were similar in both the static and rotating target experiments with similar slopes.

  11. A new approach for disruption management in airline operations control

    CERN Document Server

    Castro, António J M; Oliveira, Eugénio

    2014-01-01

    Most of the research efforts dealing with airline scheduling have been done on off-line plan optimization.  However, nowadays, with the increasingly complex and huge traffic at airports, the real challenge is how to react to unexpected events that may cause plan-disruptions, leading to flight delays. Moreover these disruptive events usually affect at least three different dimensions of the situation: the aircraft assigned to the flight, the crew assignment and, often forgotten, the passengers’ journey and satisfaction. This book includes answers to this challenge and proposes the use of the Multi-agent System paradigm to rapidly compose a multi-faceted solution to the disruptive event taking into consideration possible preferences of those three key aspects of the problem. Negotiation protocols taking place between agents that are experts in solving the different problem dimensions, combination of different utility functions and, not less important, the inclusion of the human in the automatic decision-maki...

  12. Costal cartilage fractures and disruptions in a rugby football player.

    Science.gov (United States)

    Lopez, Victor; Ma, Richard; Li, Xinning; Steele, John; Allen, Answorth A

    2013-05-01

    Costal cartilage fracture of the rib cage, or costochondral, is a rare sporting injury. For contact athletes, the instability of the rib cage may lead to potential serious complications, similar to rib fractures or thorax disruption. Most authors recommend initial conservative treatment with surgery reserved for only recalcitrant cases. We report a case of an amateur American male rugby football player who sustained a costal cartilage fracture and disruption involving the anterior left fifth and sixth rib costal cartilages. The case highlights the difficulty in establishing the diagnosis based on clinical examination and standard radiographs alone. Computed tomography was used to assist in diagnosing this destabilizing injury to the rib cage. Costal cartilage fractures and disruptions in athletes are rarely reported in the literature and can have serious implications for the athlete's ability to return to play if the rib cage is destabilized.

  13. The Interface of IT Capabilities and Disruptive Innovations

    DEFF Research Database (Denmark)

    Baiyere, Abayomi

    2017-01-01

    The occurrence of disruptive innovations tends to challenge the fabric, structure and capability that define firms facing their threat. Prior research indicates that the capacity of a firm to restructure and reconfigure its resources to face/leverage such turbulent situations is dependent on how...... well it can orchestrate its capabilities. Although IT capability has been identified as one of the essential capability of today’s organisations, managers as well as researchers are yet to uncover the dynamics through which an organisation’s IT capability can be leveraged in disruptive innovation...... situations. This paper contributes to our understanding in this direction by conceptually exploring the different roles of an organisation's IT capabilitiy in disruptive innovation scenarios. The paper provides a synthesis of the current state of knowledge about both concepts and extends this to highlight...

  14. Measurement of perceived disruption during rebuilding following Hurricane Andrew.

    Science.gov (United States)

    Burnett, K; Ironson, G; Benight, C; Wynings, C; Greenwood, D; Carver, C S; Cruess, D; Baum, A; Schneiderman, N

    1997-10-01

    The purpose of this study was to develop and evaluate a measure of perceived disruption during rebuilding following a disaster. Two eight-item scales, which measured intensity of disruption during the entire repair phase (Intensity-RP) and intensity of disruption during the past month (Intensity-PM) were developed and administered to 135 survivors of Hurricane Andrew. At 9 to 12 months postdisaster, Intensity-RP and Intensity-PM were both significantly associated with scores on the Global Severity Index of the SCL-90-R, and with scores on the Impact of Event-Intrusion Scale; Intensity-PM alone was significantly associated with PTSD scores. Regression analyses indicated that each scale contributed significant unique variance in predicting mental health symptoms, even after controlling for relevant demographic and initial disaster exposure variables.

  15. Marital Disruption and Allostatic Load in Late Life.

    Science.gov (United States)

    Rote, Sunshine

    2017-06-01

    This study examines the link between marital disruption and biological risk, and asks whether the association of this precarious life event with health is contingent on marital loss duration and history. Data are drawn from the National Social Life, Health, and Aging Project ( N = 1,414), and Poisson regressions are presented for allostatic load and logistic regressions for individual biomarkers. The currently unmarried with more distant marital disruptions exhibit higher levels of allostatic load than the currently married, which is primarily driven by dysregulation of cardiovascular and metabolic indicators. Results also reveal the differing ways marital disruption "gets under the skin" with widowhood associated with compromised inflammatory, metabolic, and cardiovascular functioning, and divorce with cardiovascular and neuroendocrine markers. Findings lend support for both the crisis and chronic strain models, and likely reflect normative expectations of the timing of life events, decrements in marital resources, and selection processes.

  16. Stellar dynamics and tidal disruption events in galactic nuclei

    Directory of Open Access Journals (Sweden)

    Alexander T.

    2012-12-01

    Full Text Available The disruption of a star by the tidal field of a massive black hole is the final outcome of a chain of complex dynamical processes in the host galaxy. I introduce the “loss cone problem”, and describe the many theoretical and numerical challenges on the path of solving it. I review various dynamical channels by which stars can be supplied to a massive black hole, and the relevant dynamical relaxation/randomization mechanisms. I briefly mention some “exotic” tidal disruption scenarios, and conclude by discussing new dynamical results that are changing our understanding of dynamics near a massive black hole, and may well be relevant for tidal disruption dynamics.

  17. Thyroid-disrupting chemicals and brain development: an update

    Directory of Open Access Journals (Sweden)

    Bilal B Mughal

    2018-04-01

    Full Text Available This review covers recent findings on the main categories of thyroid hormone–disrupting chemicals and their effects on brain development. We draw mostly on epidemiological and experimental data published in the last decade. For each chemical class considered, we deal with not only the thyroid hormone–disrupting effects but also briefly mention the main mechanisms by which the same chemicals could modify estrogen and/or androgen signalling, thereby exacerbating adverse effects on endocrine-dependent developmental programmes. Further, we emphasize recent data showing how maternal thyroid hormone signalling during early pregnancy affects not only offspring IQ, but also neurodevelopmental disease risk. These recent findings add to established knowledge on the crucial importance of iodine and thyroid hormone for optimal brain development. We propose that prenatal exposure to mixtures of thyroid hormone–disrupting chemicals provides a plausible biological mechanism contributing to current increases in the incidence of neurodevelopmental disease and IQ loss.

  18. CE: Telehealth: a case study in disruptive innovation.

    Science.gov (United States)

    Grady, Janet

    2014-04-01

    Technologic advances in health care have often outpaced our ability to integrate the technology efficiently, establish best practices for its use, and develop policies to regulate and evaluate its effectiveness. However, these may be insufficient reasons to put the brakes on innovation-particularly those "disruptive innovations" that challenge the status quo and have the potential to produce better outcomes in a number of important areas. This article discusses the concept of disruptive innovation and highlights data supporting its necessity within health care in general and nursing in particular. Focusing on telehealth as a case study in disruptive innovation, the author provides examples of its application and reviews literature that examines its effectiveness in both nursing practice and education.

  19. Designing a Supply Chain Network under the Risk of Disruptions

    Directory of Open Access Journals (Sweden)

    Armin Jabbarzadeh

    2012-01-01

    Full Text Available This paper studies a supply chain design problem with the risk of disruptions at facilities. At any point of time, the facilities are subject to various types of disruptions caused by natural disasters, man-made defections, and equipment breakdowns. We formulate the problem as a mixed-integer nonlinear program which maximizes the total profit for the whole system. The model simultaneously determines the number and location of facilities, the subset of customers to serve, the assignment of customers to facilities, and the cycle-order quantities at facilities. In order to obtain near-optimal solutions with reasonable computational requirements for large problem instances, two solution methods based on Lagrangian relaxation and genetic algorithm are developed. The effectiveness of the proposed solution approaches is shown using numerical experiments. The computational results, in addition, demonstrate that the benefits of considering disruptions in the supply chain design model can be significant.

  20. On the Papaloizou-Pringle instability in tidal disruption events

    Science.gov (United States)

    Nealon, Rebecca; Price, Daniel J.; Bonnerot, Clément; Lodato, Giuseppe

    2018-02-01

    We demonstrate that the compact, thick disc formed in a tidal disruption event may be unstable to non-axisymmetric perturbations in the form of the Papaloizou-Pringle instability. We show this can lead to rapid redistribution of angular momentum that can be parametrized in terms of an effective Shakura-Sunyaev α parameter. For remnants that have initially weak magnetic fields, this may be responsible for driving mass accretion prior to the onset of the magnetorotational instability. For tidal disruptions around a 106 M⊙ black hole, the measured accretion rate is super-Eddington but is not sustainable over many orbits. We thus identify a method by which the torus formed in tidal disruption event may be significantly accreted before the magnetorotational instability is established.

  1. Tidal disruption of fuzzy dark matter subhalo cores

    Science.gov (United States)

    Du, Xiaolong; Schwabe, Bodo; Niemeyer, Jens C.; Bürger, David

    2018-03-01

    We study tidal stripping of fuzzy dark matter (FDM) subhalo cores using simulations of the Schrödinger-Poisson equations and analyze the dynamics of tidal disruption, highlighting the differences with standard cold dark matter. Mass loss outside of the tidal radius forces the core to relax into a less compact configuration, lowering the tidal radius. As the characteristic radius of a solitonic core scales inversely with its mass, tidal stripping results in a runaway effect and rapid tidal disruption of the core once its central density drops below 4.5 times the average density of the host within the orbital radius. Additionally, we find that the core is deformed into a tidally locked ellipsoid with increasing eccentricities until it is completely disrupted. Using the core mass loss rate, we compute the minimum mass of cores that can survive several orbits for different FDM particle masses and compare it with observed masses of satellite galaxies in the Milky Way.

  2. ENHANCED TIDAL DISRUPTION RATES FROM MASSIVE BLACK HOLE BINARIES

    International Nuclear Information System (INIS)

    Chen Xian; Liu, F. K.; Madau, Piero; Sesana, Alberto

    2009-01-01

    'Hard' massive black hole (MBH) binaries embedded in steep stellar cusps can shrink via three-body slingshot interactions. We show that this process will inevitably be accompanied by a burst of stellar tidal disruptions, at a rate that can be several orders of magnitude larger than that appropriate for a single MBH. Our numerical scattering experiments reveal that (1) a significant fraction of stars initially bound to the primary hole are scattered into its tidal disruption loss cone by gravitational interactions with the secondary hole, an enhancement effect that is more pronounced for very unequal mass binaries; (2) about 25% (40%) of all strongly interacting stars are tidally disrupted by an MBH binary of mass ratio q = 1/81 (q = 1/243) and eccentricity 0.1; and (3) two mechanisms dominate the fueling of the tidal disruption loss cone, a Kozai nonresonant interaction that causes the secular evolution of the stellar angular momentum in the field of the binary, and the effect of close encounters with the secondary hole that change the stellar orbital parameters in a chaotic way. For a hard MBH binary of 10 7 M sun and mass ratio 10 -2 , embedded in an isothermal stellar cusp of velocity dispersion σ * = 100 km s -1 , the tidal disruption rate can be as large as N-dot * ∼1 yr -1 . This is 4 orders of magnitude higher than estimated for a single MBH fed by two-body relaxation. When applied to the case of a putative intermediate-mass black hole inspiraling onto Sgr A*, our results predict tidal disruption rates N-dot * ∼0.05-0.1 yr -1 .

  3. Current disruptions in the near-earth neutral sheet region

    International Nuclear Information System (INIS)

    Liu, A.T.Y.; Anderson, B.J.; Takahashi, K.; Zanetti, L.J.; McEntire, R.W.; Potemra, T.A.; Lopez, R.E.; Klumpar, D.M.; Greene, E.M.; Strangeway, R.

    1992-01-01

    Observations from the Charge Composition Explorer in 1985 and 1986 revealed fifteen current disruption events in which the magnetic field fluctuations were large and their onsets coincided well with ground onsets of substorm expansion or intensification. Over the disruption interval, the local magnetic field can change by as much as a factor of ∼7. In general, the stronger the current buildup and the closer the neutral sheet, the larger the resultant field change. There is also a tendency for a larger subsequent enhancement in the AE index with a stronger current buildup prior to current disruption. For events with good pitch angle coverage and extended observation in the neutral sheet region the authors find that the particle pressure increases toward the disruption onset and decreases afterward. Just prior to disruption, either the total particle pressure is isotropic, or the perpendicular component (P perpendicular ) dominates the parallel component (P parallel ), the plasma beta is seen to be as high as ∼70, and the observed plasma pressure gradient at the neutral sheet is large along the tail axis. The deduced local current density associated with pressure gradient is ∼27-80 n/Am 2 and is ∼85-105 mA/m when integrated over the sheet thickness. They infer from these results that just prior to the onset of current disruption, (1) an extremely thin current sheet requiring P parallel > P perpendicular for stress balance does not develop at these distances, (2) the thermal ion orbits are in the chaotic or Speiser regime while the thermal electrons are in the adiabatic regime and, in one case, exhibit peaked fluxes perpendicular to the magnetic field, thus implying no electron orbit chaotization to possibly initiate ion tearing instability, and (3) the neutral sheet is in the unstable regime specified by the cross-field current instability

  4. Summary 14 leadership principles behind the world's most disruptive company

    CERN Document Server

    2015-01-01

    Complete summary of John Rossman's book: ""The Amazon Way: 14 Leadership Principles Behind the World's Most Disruptive Company""This summary of ideas from John Rossman's book ""The Amazon Way: 14 Leadership Principles Behind the World's Most Disruptive Company"" reveals the leadership 'secrets' behind one of the biggest companies in the world. These 'secrets' are applied to all decision-making processes in the business and are used every day.There are 14 principles of leadership:1. Obsess over the customer2. Take ownership of results3. Invent and simplify4. Leaders are right - A lot5. Hire an

  5. [Technological convergence will quickly generate disruptive innovations in oncology].

    Science.gov (United States)

    Coucke, Ph A

    2016-06-01

    Convergence between information and communication technology and recent developments in medical care will totally change the health care sector. The way we perform diagnosis, treatment and follow-up will undergo disruptive changes in a very near future. We intend to highlight this statement by a limited selection of examples of radical innovations, especially in the field of oncology. To be totally disruptive and to illustrate the concept of "lateral power" - especially cognitive distribution - the list of references is only made up of internet links. Anyone - patients included - can easily and instantly access to this information everywhere.

  6. Wave form of current quench during disruptions in tokamaks

    International Nuclear Information System (INIS)

    Sugihara, Masayoshi; Gribov, Yuri; Shimada, Michiya; Lukash, Victor; Kawano, Yasunori; Yoshino, Ryuji; Miki, Nobuharu; Ohmori, Junji; Khayrutdinov, Rustam

    2003-01-01

    The time dependence of the current decay during the current quench phase of disruptions, which can significantly influence the electro-magnetic force on the in-vessel components due to the induced eddy currents, is investigated using data obtained in JT-60U experiments in order to derive a relevant physics guideline for the predictive simulations of disruptions in ITER. It is shown that an exponential decay can fit the time dependence of current quench for discharges with large quench rate (fast current quench). On the other hand, for discharges with smaller quench rate (slow current quench), a linear decay can fit the time dependence of current quench better than exponential. (author)

  7. Quorum Sensing Disruption in Vibrio harveyi Bacteria by Clay Materials.

    Science.gov (United States)

    Naik, Sajo P; Scholin, Jonathon; Ching, San; Chi, Fang; Herpfer, Marc

    2018-01-10

    This work describes the use of clay minerals as catalysts for the degradation of quorum sensing molecule N-(3-oxooctanoyl)-dl-homoserine lactone. Certain clay minerals as a result of their surface properties and porosity can catalytically degrade the quorum sensing molecule into smaller fragments. The disruption of quorum sensing by clay in a growing Gram-negative Vibrio harveyi bacteria culture was also studied by monitoring luminescence and population density of the bacteria, wherein quenching of bacterial quorum sensing activity was observed by means of luminescence reduction. The results of this study show that food-grade clays can be used as biocatalysts in disrupting bacterial activity in various media.

  8. The diagnosis of internal disc disruption with CT discography

    International Nuclear Information System (INIS)

    Liu Miao; Chen Xingcan; Li Xiaohong; Pan Yongqin

    2008-01-01

    Objective: To study the value of diagnosis for internal disc disruption (IDD)with CT discography(CTD). Methods: 42 discs of 32 patients showing no disc herniation on CT or MRI, but suffering from chronic low back pain, were undertaken CTD to work out the types of CTD with correlation between contrast medium dosages and the induction of pain. Results: CTD demonstrated 4 types of IDD which was individually correlated with the contrast dosages and induced pain; furthermore the dosages for positive and negative disc cases showed significant differece (P<0.01). Conclusions: CTD can show the direct sign of internal disc disruption, providing more information than conventional discography. (authors)

  9. Shares, gaps and the economy's response to oil disruptions

    International Nuclear Information System (INIS)

    Huntington, Hillard G.

    2004-01-01

    Most previous studies have focused on whether oil price shocks cause economic recessions but fewer studies have investigated whether the impact of an oil price shock can be different under alternative economic conditions. Using an international data set of industrialized economies, this paper explores whether an economy relying more on oil or operating closer to full employment may be more vulnerable to an oil disruption. Although the results for oil dependence are ambiguous, the analysis does find a significant relationship between the impacts of an oil shock and how closely the economy is operating to its full-employment level prior to the disruption. (Author)

  10. The potential for disruptive innovations in nuclear power

    International Nuclear Information System (INIS)

    Adams, F.P.

    2014-01-01

    The concept of 'disruptive innovation' is a management tool that provides a framework for understanding the structure and dynamics of technology markets, especially their sometimes acute response to innovation. The concept was used in a preliminary assessment of a number of energy technologies, including renewable energy technologies and energy storage, as well as nuclear technologies, as they interact in industry and the marketplace. The technologies were assessed and perspectives were provided on their current potential for innovation to disrupt the value networks behind electricity markets. The findings indicate that this concept may provide useful guidance for the planning of technology development. (author)

  11. Probing Quiescent Massive Black Holes: Insights from Tidal Disruption Events

    OpenAIRE

    Gezari, Suvi; Strubbe, Linda; Bloom, Joshua S.; Grindlay, J. E.; Soderberg, Alicia; Elvis, Martin; Coppi, Paolo; Lawrence, Andrew; Ivezic, Zeljko; Merritt, David; Komossa, Stefanie; Halpern, Jules; Eracleous, Michael

    2009-01-01

    Tidal disruption events provide a unique probe of quiescent black holes in the nuclei of distant galaxies. The next generation of synoptic surveys will yield a large sample of flares from the tidal disruption of stars by massive black holes that will give insights to four key science questions: 1) What is the assembly history of massive black holes in the universe? 2) Is there a population of intermediate mass black holes that are the primordial seeds of supermassive black holes? 3) How can w...

  12. Disruption Management in Passenger Transportation - from Air to Tracks

    DEFF Research Database (Denmark)

    Clausen, Jens

    2007-01-01

    of the world has show a dramatic increase as well. Public transportation by e.g. rail has come into focus, and hence also the service level provided by suppliers ad public transportation. These transportation systems are likewise very vulnerable to disruptions. In the airline industry there is a long tradition...... operations are becoming available. The use of advanced planning and recovery methods in the railway industry currently gains momentum. The current paper gives a short overview over the methods used for planning and disruption management in the airline industry. The situation regarding railway optimization...

  13. Use of the disruption mitigation valve in closed loop for routine protection at JET

    International Nuclear Information System (INIS)

    Reux, Cédric; Lehnen, Michael; Kruezi, Uron; Jachmich, Stefan; Card, Peter; Heinola, Kalle; Joffrin, Emmanuel; Lomas, Peter J.; Marsen, Stefan; Matthews, Guy; Riccardo, Valeria; Rimini, Fernanda; Vries, Peter de

    2013-01-01

    Highlights: ► A massive gas injection valve was used for disruption routine mitigation at JET. ► A disruption mitigation valve was integrated in JET real time systems. ► Simple triggering schemes such as mode lock were used for disruption detection. ► High forces disruptions were prevented by the use of the gas valve. ► Radiated energy is higher in mitigated disruption than in unmitigated ones. -- Abstract: Disruptions are a major concern for next-generation tokamaks, including ITER. Heat loads, electromagnetic forces and runaway electrons generated by disruptions have to be mitigated for a reliable operation of future machines. Massive gas injection is one of the methods proposed for disruption mitigation. This article reports the first use of massive gas injection as an active disruption protection system at JET. During the 2011–2012 campaigns, 67 disruptions have been mitigated by the disruption mitigation valve (DMV) following a detection by mode lock amplitude and loop voltage changes. Most of disruptions where the valve was intended to be used were successfully mitigated by the DMV, although at different stages of the typical slow disruptions of the ITER-like wall. The fraction of magnetic and thermal energy radiated during the disruption was found to be increased by the action of the DMV. Vertical forces dispersion was also reduced. No non-sustained breakdown was observed following pulses terminated by the disruption mitigation valve

  14. Use of the disruption mitigation valve in closed loop for routine protection at JET

    Energy Technology Data Exchange (ETDEWEB)

    Reux, Cédric, E-mail: cedric.reux@ccfe.ac.uk [Ecole Polytechnique, LPP, CNRS UMR 7648, 91128 Palaiseau (France); JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Lehnen, Michael; Kruezi, Uron [Association EURATOM-FZJ, Trilateral Euregio Cluster, 52425 Julich (Germany); Jachmich, Stefan [Laboratoire de Physique des Plasmas-Laboratorium voor Plasmafysica, Association EURATOM-Belgian State Institute ERM/KMS, B-1000 Brussels (Belgium); EFDA-CSU, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Card, Peter [Culham Science Centre, EURATOM/CCFE Association, Abingdon OX14 3DB (United Kingdom); Heinola, Kalle [Department of Physics, University of Helsinki, P.O. Box 64, 00014 University of Helsinki (Finland); Joffrin, Emmanuel [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Lomas, Peter J. [Culham Science Centre, EURATOM/CCFE Association, Abingdon OX14 3DB (United Kingdom); Marsen, Stefan [Max-Planck-Institut für Plasmaphysik, Teilinstitut Greifswald, EURATOM-Assoziation, D-17491 Greifswald (Germany); Matthews, Guy; Riccardo, Valeria; Rimini, Fernanda [Culham Science Centre, EURATOM/CCFE Association, Abingdon OX14 3DB (United Kingdom); Vries, Peter de [FOM Institute DIFFER, P.O. Box 1207, 3430 BE Nieuwegein (Netherlands)

    2013-10-15

    Highlights: ► A massive gas injection valve was used for disruption routine mitigation at JET. ► A disruption mitigation valve was integrated in JET real time systems. ► Simple triggering schemes such as mode lock were used for disruption detection. ► High forces disruptions were prevented by the use of the gas valve. ► Radiated energy is higher in mitigated disruption than in unmitigated ones. -- Abstract: Disruptions are a major concern for next-generation tokamaks, including ITER. Heat loads, electromagnetic forces and runaway electrons generated by disruptions have to be mitigated for a reliable operation of future machines. Massive gas injection is one of the methods proposed for disruption mitigation. This article reports the first use of massive gas injection as an active disruption protection system at JET. During the 2011–2012 campaigns, 67 disruptions have been mitigated by the disruption mitigation valve (DMV) following a detection by mode lock amplitude and loop voltage changes. Most of disruptions where the valve was intended to be used were successfully mitigated by the DMV, although at different stages of the typical slow disruptions of the ITER-like wall. The fraction of magnetic and thermal energy radiated during the disruption was found to be increased by the action of the DMV. Vertical forces dispersion was also reduced. No non-sustained breakdown was observed following pulses terminated by the disruption mitigation valve.

  15. Beryllium and graphite performance in ITER during a disruption

    International Nuclear Information System (INIS)

    Hassanein, A.; Ehst, D.A.; Gahl, J.

    1993-09-01

    Plasma disruptions are considered one of the most limiting factors for successful operation of magnetic fusion reactors. During a disruption, a sharp, rapid release of energy strikes components such as the divertor or limiter plates. Severe surface erosion and melting of these components may then occur. The amount of material eroded from both ablation and melting is important to the reactor design and component lifetime. The anticipated performance of both beryllium and graphite as plasma-facing materials during such abnormal events is analyzed and compared. Recent experimental data obtained with both plasma guns and electron beams are carefully evaluated and compared to results of analytical modeling, including vapor shielding effect. Initial results from plasma gun experiments indicate that the Be erosion rate is about five times larger than that for a graphite material under the same disruption conditions. Key differences between simulation experiments and reactor disruption on the net erosion rate, and consequently on the lifetime of the divertor plate, are discussed in detail. The advantages and disadvantages of Be over graphite as a divertor plasma-facing material are discussed

  16. Disruptive Innovation in Air Measurement Technology: Reality or Hype?

    Science.gov (United States)

    This presentation is a big picture overview on the changing state of air measurement technology in the world, with a focus on the introduction of low-cost sensors into the market place. The presentation discusses how these new technologies may be a case study in disruptive innov...

  17. Effects of Disruption Risks on Biorefinery Location Design

    Directory of Open Access Journals (Sweden)

    Yun Bai

    2015-02-01

    Full Text Available While ever-growing bio-ethanol production poses considerable challenges to the bioenergy supply chain, the risk of refinery operation disruptions further compromises the efficiency and reliability of the energy supply system. This paper applies discrete and continuous reliable facility location models to the design of reliable bio-ethanol supply chains so that the system can hedge against potential operational disruptions. The discrete model is shown to be suitable for obtaining the exact optimality for small or moderate instances, while the continuous model has superior computational tractability for large-scale applications. The impacts of both site-independent and dependent disruptions (i.e., due to flooding are analyzed in empirical case study for the State of Illinois (one of the main biomass supply states in the U.S.. The reliable solution is compared with a deterministic solution under the same setting. It is found that refinery disruptions, especially those site-dependent ones, affect both optimal refinery deployment and the supply chain cost. Sensitivity analysis is also conducted to show how refinery failure probability and fixed cost (for building biorefineries affect optimal supply chain configuration and the total expected system cost.

  18. Sleep Patterns and Sleep Disruptions in School-Age Children.

    Science.gov (United States)

    Sadeh, Avi; Raviv, Amiram; Gruber, Reut

    2000-01-01

    Assessed sleep patterns, sleep disruptions, and sleepiness of second-, fourth-, and sixth-graders. Found that older children had more delayed sleep onset times and increased reported daytime sleepiness than younger; girls spent more time in sleep than boys and had increased percentage of motionless sleep; and 18 percent of children had fragmented…

  19. Disruption and adaptation of urban transport networks from flooding

    Directory of Open Access Journals (Sweden)

    Pregnolato Maria

    2016-01-01

    Full Text Available Transport infrastructure networks are increasingly vulnerable to disruption from extreme rainfall events due to increasing surface water runoff from urbanization and changes in climate. Impacts from such disruptions typically extend far beyond the flood footprint, because of the interconnection and spatial extent of modern infrastructure. An integrated flood risk assessment couples high resolution information on depth and velocity from the CityCAT urban flood model with empirical analysis of vehicle speeds in different depths of flood water, to perturb a transport accessibility model and determine the impact of a given event on journey times across the urban area. A case study in Newcastle-upon-Tyne (UK shows that even minor flooding associate with a 1 in 10 year event can cause traffic disruptions of nearly half an hour. Two adaptation scenarios are subsequently tested (i hardening (i.e. flood protection a single major junction, (ii introduction of green roofs across all buildings. Both options have benefits in terms of reduced disruption, but for a 1 in 200 year event greening all roofs in the city provided only three times the benefit of protecting one critical road junction, highlighting the importance of understanding network attributes such as capacity and flows.

  20. Balancing Disruptive Students' Rights with Campus Safety

    Science.gov (United States)

    Matthew, Kathryn I.; Kajs, Lawrence; Matthew, Millard E.

    2017-01-01

    Disruptive students potentially pose significant problems for campus administrators as they strive to maintain a safe campus environment conducive to learning while not violating the legal rights of the students. Maintaining a safe campus is important because increasing numbers of students with mental and cognitive disorders are enrolling in…

  1. Endocrine-disrupting chemicals: associated disorders and mechanisms of action.

    Science.gov (United States)

    De Coster, Sam; van Larebeke, Nicolas

    2012-01-01

    The incidence and/or prevalence of health problems associated with endocrine-disruption have increased. Many chemicals have endocrine-disrupting properties, including bisphenol A, some organochlorines, polybrominated flame retardants, perfluorinated substances, alkylphenols, phthalates, pesticides, polycyclic aromatic hydrocarbons, alkylphenols, solvents, and some household products including some cleaning products, air fresheners, hair dyes, cosmetics, and sunscreens. Even some metals were shown to have endocrine-disrupting properties. Many observations suggesting that endocrine disruptors do contribute to cancer, diabetes, obesity, the metabolic syndrome, and infertility are listed in this paper. An overview is presented of mechanisms contributing to endocrine disruption. Endocrine disruptors can act through classical nuclear receptors, but also through estrogen-related receptors, membrane-bound estrogen-receptors, and interaction with targets in the cytosol resulting in activation of the Src/Ras/Erk pathway or modulation of nitric oxide. In addition, changes in metabolism of endogenous hormones, cross-talk between genomic and nongenomic pathways, cross talk with estrogen receptors after binding on other receptors, interference with feedback regulation and neuroendocrine cells, changes in DNA methylation or histone modifications, and genomic instability by interference with the spindle figure can play a role. Also it was found that effects of receptor activation can differ in function of the ligand.

  2. Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of Action

    Directory of Open Access Journals (Sweden)

    Sam De Coster

    2012-01-01

    Full Text Available The incidence and/or prevalence of health problems associated with endocrine-disruption have increased. Many chemicals have endocrine-disrupting properties, including bisphenol A, some organochlorines, polybrominated flame retardants, perfluorinated substances, alkylphenols, phthalates, pesticides, polycyclic aromatic hydrocarbons, alkylphenols, solvents, and some household products including some cleaning products, air fresheners, hair dyes, cosmetics, and sunscreens. Even some metals were shown to have endocrine-disrupting properties. Many observations suggesting that endocrine disruptors do contribute to cancer, diabetes, obesity, the metabolic syndrome, and infertility are listed in this paper. An overview is presented of mechanisms contributing to endocrine disruption. Endocrine disruptors can act through classical nuclear receptors, but also through estrogen-related receptors, membrane-bound estrogen-receptors, and interaction with targets in the cytosol resulting in activation of the Src/Ras/Erk pathway or modulation of nitric oxide. In addition, changes in metabolism of endogenous hormones, cross-talk between genomic and nongenomic pathways, cross talk with estrogen receptors after binding on other receptors, interference with feedback regulation and neuroendocrine cells, changes in DNA methylation or histone modifications, and genomic instability by interference with the spindle figure can play a role. Also it was found that effects of receptor activation can differ in function of the ligand.

  3. North Sea submarine cable disruptions and fishing activity

    NARCIS (Netherlands)

    Hintzen, N.T.; Machiels, M.A.M.

    2014-01-01

    At the North Sea seafloor, numerous submarine cables are positioned that connect telecommunication networks between countries. Worldwide, human activities cause most of the cable disruptions with fisheries accounting for nearly half of all reported faults. Due to a recent increase of submarine cable

  4. Disruptive Ideas for Power Grid Security and Resilience With DER

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, Erfan [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-10-23

    This presentation by Erfan Ibrahim was prepared for NREL's 2017 Cybersecurity and Reslience Workshop on distributed energy resource (DER) best practices. The presentation provides an overview of NREL's Cyber-Physical Systems Security and Resilience R&D Center, the Center's approach to cybersecurity, and disruptive ideas for power grid security and resilience with DER.

  5. Disrupting the Dissertation: Linked Data, Enhanced Publication and Algorithmic Culture

    Science.gov (United States)

    Tracy, Frances; Carmichael, Patrick

    2017-01-01

    This article explores how the three aspects of Striphas' notion of algorithmic culture (information, crowds and algorithms) might influence and potentially disrupt established educational practices. We draw on our experience of introducing semantic web and linked data technologies into higher education settings, focussing on extended student…

  6. Review: Endocrine disrupting chemicals (phenol and phthalates) in ...

    African Journals Online (AJOL)

    There has been increasing concern about the impacts of exposure to chemical compounds with endocrine disrupting activities in the environment, especially aquatic environments, to wildlife and humans. South Africa is known to have used and abused most chemicals listed by developed and developing countries as ...

  7. Mixture effects of endocrine disrupting compounds in vitro

    DEFF Research Database (Denmark)

    Kjærstad, Mia Birkhøj; Taxvig, Camilla; Andersen, H. R.

    2010-01-01

    assuming additivity. Overall these and other studies show that weak endocrine disrupting compounds, like parabens and azole fungicides, give rise to combination effects when they occur in mixtures. These combination effects should be taken into account in regulatory risk assessment not to under...

  8. Disrupting Myths of Poverty in the Face of Resistance

    Science.gov (United States)

    Pollock, Katina; Lopez, Ann; Joshee, Reva

    2013-01-01

    This case disrupts some of the prevalent myths about families from low-income and poor households held by educators. Recognizing the inherent tensions, this case demonstrates the importance of creating equitable and inclusive learning environments. We presented some of the challenges faced by Marcus, a progressive principal, as he attempts to…

  9. Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

    Science.gov (United States)

    Sukhai, Mahadeo A.; Prabha, Swayam; Hurren, Rose; Rutledge, Angela C.; Lee, Anna Y.; Sriskanthadevan, Shrivani; Sun, Hong; Wang, Xiaoming; Skrtic, Marko; Seneviratne, Ayesh; Cusimano, Maria; Jhas, Bozhena; Gronda, Marcela; MacLean, Neil; Cho, Eunice E.; Spagnuolo, Paul A.; Sharmeen, Sumaiya; Gebbia, Marinella; Urbanus, Malene; Eppert, Kolja; Dissanayake, Dilan; Jonet, Alexia; Dassonville-Klimpt, Alexandra; Li, Xiaoming; Datti, Alessandro; Ohashi, Pamela S.; Wrana, Jeff; Rogers, Ian; Sonnet, Pascal; Ellis, William Y.; Corey, Seth J.; Eaves, Connie; Minden, Mark D.; Wang, Jean C.Y.; Dick, John E.; Nislow, Corey; Giaever, Guri; Schimmer, Aaron D.

    2012-01-01

    Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened a library of on- and off-patent drugs and identified the antimalarial agent mefloquine as a compound that selectively kills AML cells and AML stem cells in a panel of leukemia cell lines and in mice. Using a yeast genome-wide functional screen for mefloquine sensitizers, we identified genes associated with the yeast vacuole, the homolog of the mammalian lysosome. Consistent with this, we determined that mefloquine disrupts lysosomes, directly permeabilizes the lysosome membrane, and releases cathepsins into the cytosol. Knockdown of the lysosomal membrane proteins LAMP1 and LAMP2 resulted in decreased cell viability, as did treatment of AML cells with known lysosome disrupters. Highlighting a potential therapeutic rationale for this strategy, leukemic cells had significantly larger lysosomes compared with normal cells, and leukemia-initiating cells overexpressed lysosomal biogenesis genes. These results demonstrate that lysosomal disruption preferentially targets AML cells and AML progenitor cells, providing a rationale for testing lysosomal disruption as a novel therapeutic strategy for AML. PMID:23202731

  10. Heat transfer modelling of first walls subject to plasma disruption

    International Nuclear Information System (INIS)

    Fillo, J.A.; Makowitz, H.

    1981-01-01

    A brief description of the plasma disruption problem and potential thermal consequences to the first wall is given. Thermal models reviewed include: a) melting of a solid with melt layer in place; b) melting of a solid with complete removal of melt (ablation); c) melting/vaporization of a solid; and d) vaporization of a solid but no phase change affecting the temperature profile

  11. Reproducing (and Disrupting) Heteronormativity: Gendered Sexual Socialization in Preschool Classrooms

    Science.gov (United States)

    Gansen, Heidi M.

    2017-01-01

    Using ethnographic data from 10 months of observations in nine preschool classrooms, I examine gendered sexual socialization children receive from teachers' practices and reproduce through peer interactions. I find heteronormativity permeates preschool classrooms, where teachers construct (and occasionally disrupt) gendered sexuality in a number…

  12. Multiphoton imaging the disruptive nature of sulfur mustard lesions

    Science.gov (United States)

    Werrlein, Robert J.; Braue, Catherine R.; Dillman, James F.

    2005-03-01

    Sulfur mustard [bis-2-chloroethyl sulfide] is a vesicating agent first used as a weapon of war in WWI. It causes debilitating blisters at the epidermal-dermal junction and involves molecules that are also disrupted by junctional epidermolysis bullosa (JEB) and other blistering skin diseases. Despite its recurring use in global conflicts, there is still no completely effective treatment. We have shown by imaging human keratinocytes in cell culture and in intact epidermal tissues that the basal cells of skin contain well-organized molecules (keratins K5/K14, α6β4 integrin, laminin 5 and α3β1 integrin) that are early targets of sulfur mustard. Disruption and collapse of these molecules is coincident with nuclear displacement, loss of functional asymmetry, and loss of polarized mobility. The progression of this pathology precedes basal cell detachment by 8-24 h, a time equivalent to the "clinical latent phase" that defines the extant period between agent exposure and vesication. Our images indicate that disruption of adhesion-complex molecules also impairs cytoskeletal proteins and the integration of structures required for signal transduction and tissue repair. We have recently developed an optical system to test this hypothesis, i.e., to determine whether and how the early disruption of target molecules alters signal transduction. This environmentally controlled on-line system provides a nexus for real-time correlation of imaged lesions with DNA microarray analysis, and for using multiphoton microscopy to facilitate development of more effective treatment strategies.

  13. Disruption of the human gut microbiota following Norovirus infection.

    Directory of Open Access Journals (Sweden)

    Adam M Nelson

    Full Text Available The gut microbiota, the collection of all bacterial members in the intestinal tract, plays a key role in health. Disruption of the indigenous microbiota by a variety of stressors, including antibiotic therapy and intestinal infections, is associated with multiple health problems. We sought to determine if infection with Norovirus disrupts the gut microbiota. Barcoded pyrosequencing of the 16S rRNA-encoding gene was used to characterize the stool microbiota in Norovirus-infected human patients (n = 38. While the microbiota in most infected patients (n = 31 resembled that seen in uninfected healthy controls, a minority of patients (n = 7 possessed a significantly altered microbiota characterized by reduced relative numbers of Bacteriodetes and a corresponding increase in Proteobacteria. In these patients, the increase in Proteobacteria was due to a single operational taxonomic unit (OTU of Escherichia coli. We cultured E. coli from Norovirus-infected patients and characterized them using PCR-ribotyping and virulence factor analysis. Multiple ribotypes were encountered, but none possessed typical virulence factors commonly carried by enteropathogenic E. coli strains. Microbiota disruption and elevated Proteobacteria were not significantly correlated to patient age, gender, sampling time following illness onset, or overall gut inflammation. These results demonstrate that some patients have a disrupted microbiota following Norovirus infection, and therefore may be at elevated risk for long-term health complications.

  14. Consequences of family disruption on children's educational outcomes in Norway.

    Science.gov (United States)

    Steele, Fiona; Sigle-Rushton, Wendy; Kravdal, Øystein

    2009-08-01

    Using high-quality data from Norwegian population registers, we examine the relationship between family disruption and children's educational outcomes. We distinguish between disruptions caused by parental divorce and paternal death and, using a simultaneous equation model, pay particular attention to selection bias in the effect of divorce. We also allow for the possibility that disruption may have different effects at different stages of a child's educational career. Our results suggest that selection on time-invariant maternal characteristics is important and works to overstate the effects of divorce on a child's chances of continuing in education. Nevertheless, the experience of marital breakdown during childhood is associated with lower levels of education, and the effect weakens with the child's age at disruption. The effects of divorce are most pronounced for the transitions during or just beyond the high school level. In models that do not allow for selection, children who experienced a father's death appear less disadvantaged than children whose parents divorced. After we control for selection, however differences in the educational qualifications of children from divorced and bereaved families narrow substantially and, at mean ages of divorce, are almost non-existent.

  15. Just one look: Direct gaze briefly disrupts visual working memory.

    Science.gov (United States)

    Wang, J Jessica; Apperly, Ian A

    2017-04-01

    Direct gaze is a salient social cue that affords rapid detection. A body of research suggests that direct gaze enhances performance on memory tasks (e.g., Hood, Macrae, Cole-Davies, & Dias, Developmental Science, 1, 67-71, 2003). Nonetheless, other studies highlight the disruptive effect direct gaze has on concurrent cognitive processes (e.g., Conty, Gimmig, Belletier, George, & Huguet, Cognition, 115(1), 133-139, 2010). This discrepancy raises questions about the effects direct gaze may have on concurrent memory tasks. We addressed this topic by employing a change detection paradigm, where participants retained information about the color of small sets of agents. Experiment 1 revealed that, despite the irrelevance of the agents' eye gaze to the memory task at hand, participants were worse at detecting changes when the agents looked directly at them compared to when the agents looked away. Experiment 2 showed that the disruptive effect was relatively short-lived. Prolonged presentation of direct gaze led to recovery from the initial disruption, rather than a sustained disruption on change detection performance. The present study provides the first evidence that direct gaze impairs visual working memory with a rapidly-developing yet short-lived effect even when there is no need to attend to agents' gaze.

  16. Collaborate or not? : A system dynamics study on disruption recovery

    NARCIS (Netherlands)

    Zhu, Quan; Krikke, Harold; Caniels, Marjolein C. J.

    2016-01-01

    Purpose – The purpose of this paper is to investigate different combinations of collaboration strategies to deal with different types of supply chain disruptions, find the best combination, and provide targeting suggestions for investments. Design/methodology/approach – A system dynamics simulation

  17. Interdependent, Dependent, and Independent Group Contingencies for Controlling Disruptive Behavior.

    Science.gov (United States)

    Gresham, Frank M.; Gresham, Gwenyth N.

    1982-01-01

    Three group-oriented contingency systems (interdependent, dependent, and independent) were compared to evaluate each system's effectiveness in controlling the disruptive behavior of a self-contained classroom of 12 educable mentally retarded elementary-aged children. Interdependent and dependent group contingency systems were more effective than…

  18. Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

    DEFF Research Database (Denmark)

    Hartoft-Nielsen, Marie-Louise; Boas, Malene; Bliddal, Sofie

    2011-01-01

    Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals-endocrine disrupting chemicals (EDCs)-has been shown to cause almost...

  19. Social media disruptive change in healthcare : responses of healthcare providers

    NARCIS (Netherlands)

    Smailhodzic, Edin; Boonstra, Albert; Langley, David

    Social media represent specific types of technologies that are end-user driven and end-users are able to drive disruptive change giving little time to organizations to react. With rapid and powerful emergence of social media communities in healthcare, this sector is faced with new and alternative

  20. Social media disruptive change in healthcare : Responses of healthcare providers?

    NARCIS (Netherlands)

    Smailhodzic, E.; Boonstra, A.; Langley, D.J.

    2016-01-01

    Social media represent specific types of technologies that are end-user driven and end-users are able to drive disruptive change giving little time to organizations to react. With rapid and powerful emergence of social media communities in healthcare, this sector is faced with new and alternative

  1. Parental Divorce, Life-Course Disruption, and Adult Depression.

    Science.gov (United States)

    Ross, Catherine E.; Mirowsky, John

    1999-01-01

    Reports on a national sample of adults (N=2,592) surveyed on the association between adult depression and childhood parental divorce. Results suggest that parental divorce may disrupt a person's life course and create lifelong consequences for their well being, by lowering socioeconomic status and increasing problems in interpersonal…

  2. Management Control System Support of Initiatives for Disruptive Students

    Science.gov (United States)

    Scott, Colin

    2011-01-01

    Purpose: The purpose of the paper is to investigate the management control system (MCS) support of school initiatives to develop the school climate and to re-engage disruptive students. Design/methodology/approach: The paper adopts an approach of critical action research interviews with management and document reviews informed by Habermasian…

  3. Endocrine-disrupting chemicals and public health protection

    DEFF Research Database (Denmark)

    Zoeller, R Thomas; Brown, T R; Doan, L L

    2012-01-01

    An endocrine-disrupting chemical (EDC) is an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. The potential for deleterious effects of EDC must be considered relative to the regulation of hormone synthesis, secretion, and actions and the variabili...

  4. Intellectual Disability Modifies Gender Effects on Disruptive Behaviors

    Science.gov (United States)

    Einfeld, Stewart L.; Gray, Kylie M.; Ellis, Louise A.; Taffe, John; Emerson, Eric; Tonge, Bruce J.; Horstead, Sian K.

    2010-01-01

    In typically developing children, boys are more commonly diagnosed than girls with disruptive behavior disorders, namely, attention-deficit/hyperactivity disorder, conduct disorder, and oppositional defiant disorder. For children with intellectual disability (ID), the evidence for this gender effect is less clear. In this report we examine gender…

  5. High Trait Anxiety: A Challenge for Disrupting Fear Memory Reconsolidation

    Science.gov (United States)

    Soeter, Marieke; Kindt, Merel

    2013-01-01

    Disrupting reconsolidation may be promising in the treatment of anxiety disorders but the fear-reducing effects are thus far solely demonstrated in the average organism. A relevant question is whether disrupting fear memory reconsolidation is less effective in individuals who are vulnerable to develop an anxiety disorder. By collapsing data from six previous human fear conditioning studies we tested whether trait anxiety was related to the fear-reducing effects of a pharmacological agent targeting the process of memory reconsolidation - n = 107. Testing included different phases across three consecutive days each separated by 24 h. Fear responding was measured by the eye-blink startle reflex. Disrupting the process of fear memory reconsolidation was manipulated by administering the β-adrenergic receptor antagonist propranolol HCl either before or after memory retrieval. Trait anxiety uniquely predicted the fear-reducing effects of disrupting memory reconsolidation: the higher the trait anxiety, the less fear reduction. Vulnerable individuals with the propensity to develop anxiety disorders may need higher dosages of propranolol HCl or more retrieval trials for targeting and changing fear memory. Our finding clearly demonstrates that we cannot simply translate observations from fundamental research on fear reduction in the average organism to clinical practice. PMID:24260096

  6. High trait anxiety: a challenge for disrupting fear memory reconsolidation.

    Directory of Open Access Journals (Sweden)

    Marieke Soeter

    Full Text Available Disrupting reconsolidation may be promising in the treatment of anxiety disorders but the fear-reducing effects are thus far solely demonstrated in the average organism. A relevant question is whether disrupting fear memory reconsolidation is less effective in individuals who are vulnerable to develop an anxiety disorder. By collapsing data from six previous human fear conditioning studies we tested whether trait anxiety was related to the fear-reducing effects of a pharmacological agent targeting the process of memory reconsolidation--n = 107. Testing included different phases across three consecutive days each separated by 24 h. Fear responding was measured by the eye-blink startle reflex. Disrupting the process of fear memory reconsolidation was manipulated by administering the β-adrenergic receptor antagonist propranolol HCl either before or after memory retrieval. Trait anxiety uniquely predicted the fear-reducing effects of disrupting memory reconsolidation: the higher the trait anxiety, the less fear reduction. Vulnerable individuals with the propensity to develop anxiety disorders may need higher dosages of propranolol HCl or more retrieval trials for targeting and changing fear memory. Our finding clearly demonstrates that we cannot simply translate observations from fundamental research on fear reduction in the average organism to clinical practice.

  7. Modelling multi-ion plasma gun simulations of Tokamak disruptions

    International Nuclear Information System (INIS)

    Ehst, D.A.

    1995-08-01

    The effect of impurity ions in plasma gun ablation tests of various targets is considered. Inclusion of reasonable amounts of impurity (∼10%) is adequate to explain observed energy transmission and erosion measurements. The gun tests and the computer code calculations are relevant to the parameter range expected for major disruptions on large tokamaks

  8. Educational Games and Virtual Reality as Disruptive Technologies

    Science.gov (United States)

    Psotka, Joseph

    2013-01-01

    New technologies often have the potential for disrupting existing established practices, but nowhere is this so pertinent as in education and training today. And yet, education has been glacially slow to adopt these changes in a large scale way, and innovations seem to be imposed mainly by students' and their changing social lifestyles than…

  9. School Counselors Serving Students with Disruptive Behavior Disorders

    Science.gov (United States)

    Grothaus, Tim

    2013-01-01

    School counselors are in a prime position to collaborate with school and community stakeholders to both prevent and respond to the challenges experienced and exhibited by students with one or more disruptive behavior disorders (DBD). In this article, the DBDs discussed include conduct disorder, oppositional defiant disorder, intermittent explosive…

  10. Tidal disruption of white dwarfs by intermediate mass black holes

    Directory of Open Access Journals (Sweden)

    Bode T.

    2012-12-01

    Full Text Available Modeling ultra-close encounters between a white dwarf and a spinning, intermediate mass black hole requires a full general relativistic treatment of gravity. This paper summarizes results from such a study. Our results show that the disruption process and prompt accretion of the debris strongly depend on the magnitude and orientation of the black hole spin. On the other hand, the late-time accretion onto the black hole follows the same decay, Ṁ ∝  t−5/3, estimated from Newtonian gravity disruption studies. The spectrum of the fallback material peaks in the soft X-rays and sustains Eddington luminosity for 1–3 yrs after the disruption. The orientation of the black hole spin has also a profound effect on how the outflowing debris obscures the central region. The disruption produces a burst of gravitational radiation with characteristic frequencies of ∼3.2 Hz and strain amplitudes of ∼10−18 for galactic intermediate mass black holes.

  11. Abundance – A new window on how disruptive innovation occurs

    NARCIS (Netherlands)

    Mahto, Raj V.; Belousova, Olga; Ahluwalia, Saurabh

    2018-01-01

    The economic philosophy of abundance has provided a new portal to view disruptive innovation. After decades of the world's middle class shrinking and the poor becoming poorer the abundance concept has created an interest in the “Rising Billion” transforming the poor into a more viable economic force

  12. Effect of irrigation disruption and biological nitrogen on growth and ...

    African Journals Online (AJOL)

    In addition, the maximum (4.29 %) harvest index was obtained from irrigation disruption at third and second harvest with 9 L/ha of nitroxin application. In conclusion, lower amounts of nitrogen was needed to produced the optimal yield of seed in water deficit situation compared with non stress condition, while the nitrogen ...

  13. Assessment of accident energetics in LMFBR core-disruptive accidents

    International Nuclear Information System (INIS)

    Fauske, H.K.

    1977-01-01

    An assessment of accident energetics in LMFBR core-disruptive accidents is given with emphasis on the generic issues of energetic recriticality and energetic fuel-coolant interaction events. Application of a few general behavior principles to the oxide-fueled system suggests that such events are highly unlikely following a postulated core meltdown event

  14. The association of telomere length with family violence and disruption.

    Science.gov (United States)

    Drury, Stacy S; Mabile, Emily; Brett, Zoë H; Esteves, Kyle; Jones, Edward; Shirtcliff, Elizabeth A; Theall, Katherine P

    2014-07-01

    To enhance the understanding of biological mechanisms connecting early adversity and negative health, we examine the association between family interpersonal violence and disruption and telomere length in youth. These specific exposures were selected because of their established links with negative health consequences across the life-course. Children, age 5 to 15, were recruited from the greater New Orleans area, and exposure to family disruption and violence was assessed through caregiver report. Telomere length, from buccal cell DNA (buccal telomere length [bTL]), was determined by using monochrome multiplex quantitative real-time polymerase chain reaction. The association between bTL and adversity exposure was tested (n = 80). Cumulative exposure to interpersonal violence and family disruption was correlated with bTL. Controlling for other sociodemographic factors, bTL was significantly shorter in children with higher exposure to family violence and disruption. Witnessing family violence exerted a particularly potent impact. A significant gender interaction was found (β = -0.0086, SE = 0.0031, z test= -2.79, P = .0053) and analysis revealed the effect only in girls. bTL is a molecular biomarker of adversity and allostatic load that is detectable in childhood. The present results extend previous studies by demonstrating that telomeres are sensitive to adversity within the overarching family domain. These findings suggest that the family ecology may be an important target for interventions to reduce the biological impact of adversity in the lives of children. Copyright © 2014 by the American Academy of Pediatrics.

  15. Verbal Overshadowing: Disrupting Memory in Postsecondary Adult Students

    Science.gov (United States)

    O'Guin, Jerold C.

    2010-01-01

    Verbal overshadowing is the later disruption of recognition memory resulting from prior verbal recall of the memory. Cognitive psychologists in the field of criminal justice have studied the effect since 1990 due to its ramifications in eyewitness testimony. Because of its short history of research, the effects of verbal overshadowing in the…

  16. Robust Optimization of Fourth Party Logistics Network Design under Disruptions

    Directory of Open Access Journals (Sweden)

    Jia Li

    2015-01-01

    Full Text Available The Fourth Party Logistics (4PL network faces disruptions of various sorts under the dynamic and complex environment. In order to explore the robustness of the network, the 4PL network design with consideration of random disruptions is studied. The purpose of the research is to construct a 4PL network that can provide satisfactory service to customers at a lower cost when disruptions strike. Based on the definition of β-robustness, a robust optimization model of 4PL network design under disruptions is established. Based on the NP-hard characteristic of the problem, the artificial fish swarm algorithm (AFSA and the genetic algorithm (GA are developed. The effectiveness of the algorithms is tested and compared by simulation examples. By comparing the optimal solutions of the 4PL network for different robustness level, it is indicated that the robust optimization model can evade the market risks effectively and save the cost in the maximum limit when it is applied to 4PL network design.

  17. Monoclonal antibodies AC-43 and AC-29 disrupt Plasmodium vivax ...

    Indian Academy of Sciences (India)

    Prakash

    Therefore, these glycoproteins appear to be potential candidates for a vector- directed transmission-blocking vaccine (TBV). [Chugh M, Gulati B R and Gakhar S K 2010 Monoclonal antibodies AC-43 and AC-29 disrupt Plasmodium vivax development in the Indian malaria vector Anopheles culicifacies (Diptera: culicidae); J.

  18. Novel naval technologies: Sustaining or disrupting naval doctrine

    NARCIS (Netherlands)

    te Kulve, Haico; Smit, Willem A.

    2010-01-01

    The defense sector is generally known to be simultaneously conservative and enthusiastic about novel technologies. Uptake of new technologies by the military may differ depending on the perceived impact of new technologies. Introduction of technological changes can sustain or disrupt doctrine and

  19. E-learning as augmentation rather than disruption

    DEFF Research Database (Denmark)

    Heilesen, Simon; Josephsen, Jens

    2007-01-01

    levels. And that this may well account for some of the present disillusionment with e-learning. Further, we argue that e-learning already has had a significant impact on our world view and understanding of education and that questions of augmentation or disruption should be studied over a long period...

  20. Sgr A* flares: tidal disruption of asteroids and planets?

    NARCIS (Netherlands)

    Zubovas, K.; Nayakshin, S.; Markoff, S.

    2012-01-01

    It is theoretically expected that a supermassive black hole (SMBH) in the centre of a typical nearby galaxy disrupts a solar-type star every ∼105 yr, resulting in a bright flare lasting for months. Sgr A*, the resident SMBH of the Milky Way, produces (by comparison) tiny flares that last only hours

  1. Disruption Management for an Airline - Rescheduling of aircraft

    DEFF Research Database (Denmark)

    Larsen, Jesper; Løve, Michael; Sørensen, Kim Riis

    2002-01-01

    The Aircraft Recovery Problem (ARP) involves decisions concerning aircraft to flight assignments in situations where unforseen events have disrupted the existing flight schedule, e.g. bad weather causing flight delays. The aircraft recovery problem aims to recover these flight schedules through a...

  2. Biomarkers for circadian rhythm disruption independent of time of day

    NARCIS (Netherlands)

    K.C.G. van Dycke (Kirsten); J.L.A. Pennings (Jeroen L.A.); C.T.M. van Oostrom (Conny); L.W.M. Van Kerkhof (Linda W.M.); H. van Steeg (Harry); G.T.J. van der Horst (Gijsbertus); W. Rodenburg (Wendy)

    2015-01-01

    textabstractFrequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the presence of circadian rhythm disturbance (CRD), including melatonin, cortisol and body temperature, require 24-hr ("around the

  3. Nobility, Competence, and Disruption: Challenges to Teacher Education

    Science.gov (United States)

    Fenstermacher, Gary D.

    2015-01-01

    This article was comprises the keynote address presented by Gary D. Fenstermacher, at the Conference of the California Council on Teacher Education (CCTE), March 19, 2015, in San Jose, California. The subject covered Nobility, Competence, and Disruption and what they mean in teacher education. Fenstermacher presents his subject in four assertions:…

  4. Evaluating Alzheimer's Disease Progression by Modeling Crosstalk Network Disruption

    Science.gov (United States)

    Liu, Haochen; Wei, Chunxiang; He, Hua; Liu, Xiaoquan

    2016-01-01

    Aβ, tau, and P-tau have been widely accepted as reliable markers for Alzheimer's disease (AD). The crosstalk between these markers forms a complex network. AD may induce the integral variation and disruption of the network. The aim of this study was to develop a novel mathematic model based on a simplified crosstalk network to evaluate the disease progression of AD. The integral variation of the network is measured by three integral disruption parameters. The robustness of network is evaluated by network disruption probability. Presented results show that network disruption probability has a good linear relationship with Mini Mental State Examination (MMSE). The proposed model combined with Support vector machine (SVM) achieves a relative high 10-fold cross-validated performance in classification of AD vs. normal and mild cognitive impairment (MCI) vs. normal (95% accuracy, 95% sensitivity, 95% specificity for AD vs. normal; 90% accuracy, 94% sensitivity, 83% specificity for MCI vs. normal). This research evaluates the progression of AD and facilitates AD early diagnosis. PMID:26834548

  5. Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures

    Science.gov (United States)

    Skene, Debra J.; Arendt, Josephine; Cade, Janet E.; Grant, Peter J.; Hardie, Laura J.

    2016-01-01

    Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important. PMID:27763782

  6. Dynamic communications for small satellites using disruption tolerant network concepts

    NARCIS (Netherlands)

    Giuditta, N.; Gill, E.K.A.; Fernández, B.; Isaac, D.

    2009-01-01

    New network technologies are providing interconnectivity in areas previously unheard of. One of these novel technologies, named Disruption Tolerant Networking (DTN), shows promise for the space industry. In order to study its suitability for University projects, a model of a University space mission

  7. Propranolol disrupts consolidation of emotional memory in Lymnaea.

    Science.gov (United States)

    Shymansky, Tamila; Hughes, Emily; Rothwell, Cailin M; Lukowiak, Ken

    2018-03-01

    The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the invertebrate model Lymnaea to study propranolol's ability to disrupt consolidation of memories formed under varying various types of stress which cause differing degrees of emotional memory. We show that when propranolol is administered immediately following operant conditioning, only the consolidation process of memories enhanced by individual stressors (i.e. a non-emotional memory) is susceptible to disruption. However, when propranolol is administered prior to training, only memories enhanced by a combination of stressors leading to an emotional memory are susceptible to disruption. These data suggest that the time of propranolol administration, as well as the type of memory formed play a key role in propranolol's ability to obstruct memory consolidation. Copyright © 2018 Elsevier Inc. All rights reserved.

  8. Disrupting circadian rhythms in rats induces retrograde amnesia

    NARCIS (Netherlands)

    Fekete, Mátyás; Ree, J.M. van; Niesink, Raymond J.M.; Wied, D. de

    1985-01-01

    Disrupting circadian organization in rats by phase-shifting the illumination cycle or by exposure to a reversed day/night cycle or to continuous light, resulted in retrograde amnesia for passive avoidance behavior. This retrograde amnesia induced by phase-shifting lasted at least 2 days, and

  9. Enhanced Turbulence During the Energy Quench of Disruptions

    NARCIS (Netherlands)

    Remkes, G. J. J.; Schüller, F. C.

    1991-01-01

    Enhanced electron density fluctuation levels with frequencies in the megahertz range have been observed during the energy quench phase of minor disruptions in the TORTUR Tokamak. The high frequencies of the phenomena indicate that the enhanced transport during the energy quench is caused by

  10. Disruptive colonial boundaries and attempts to resolve land ...

    African Journals Online (AJOL)

    But on closer examination it became clear that land/boundary disputes in the region have their roots in European colonialism, and derive largely from administrative policies that were disruptive on inter-village boundaries. Despite the efforts of British colonial authorities at resolving these disputes before the close of the ...

  11. Production control and supplier selection under demand disruptions

    Directory of Open Access Journals (Sweden)

    Xianzhe Chen

    2010-12-01

    Full Text Available This paper investigates the effects of demand disruptions on production control and supplier selection in a three-echelon supply chain system. The customer demand is modeled as a jump-diffusion process in a continuous-time setting. A two-number production-inventory policy is implemented in the production control model for the manufacturer. The objective is to minimize the long-term average total cost consisting of backlog cost, holding cost, switching cost, and ordering cost. The simulated annealing method is applied to search the optimal critical switching values. Furthermore, an improved analytical hierarchy process (AHP is proposed to select the best supplier, based on quantitative factors such as the optimal long-term total cost obtained through the simulated annealing method under demand disruptions and qualitative factors such as quality and service. Numerical studies are conducted to demonstrate the effects of demand disruptions in the face of various risk scenarios. Managerial insights from simulation results are provided as well. Our approaches can be implemented as the “stress test” for companies in front of various supply chain disruption scenarios.

  12. Different cell disruption methods for astaxanthin recovery by Phaffia ...

    African Journals Online (AJOL)

    Astaxanthin (3,3'-dihydroxy-b,b'-carotene-4,4'-dione) is carotenoid of high market value whose demand has increased in such fields as aquaculture, pharmaceutical supplements and natural coloring. Cell disruption is the first step for isolating intracellular materials and it depends on the cell wall permeability. In order to ...

  13. Sustainable and Resilient Supply Chain Network Design under Disruption Risks

    Directory of Open Access Journals (Sweden)

    Sonia Irshad Mari

    2014-09-01

    Full Text Available Sustainable supply chain network design is a rich area for academic research that is still in its infancy and has potential to affect supply chain performance. Increasing regulations for carbon and waste management are forcing firms to consider their supply chains from ecological and social objectives, but in reality, however, facilities and the links connecting them are disrupted from time to time, due to poor weather, natural or manmade disasters or a combination of any other factors. Supply chain systems drop their sustainability objectives while coping with these unexpected disruptions. Hence, the new challenges for supply chain managers are to design an efficient and effective supply chain network that will be resilient enough to bounce back from any disruption and that also should have sufficient vigilance to offer same sustainability under a disruption state. This paper focuses on ecological sustainability, because an environmental focus in a supply chain system is more important and also links with other pillars of sustainability, as the products need to be produced, packed and transported in an ethical way, which should not harm social balance and the environment. Owing to importance of the considered issue, this paper attempts to introduce a network optimization model for a sustainable and resilient supply chain network by incorporating (1 sustainability via carbon emissions and embodied carbon footprints and (2 resilience by incorporating location-specific risks. The proposed goal programming (GP model optimizes the total cost, while considering the resilience and sustainability of the supply chain network.

  14. Hydrogeologic effects of natural disruptive events on nuclear waste repositories

    International Nuclear Information System (INIS)

    Davis, S.N.

    1980-06-01

    Some possible hydrogeologic effects of disruptive events that may affect repositories for nuclear waste are described. A very large number of combinations of natural events can be imagined, but only those events which are judged to be most probable are covered. Waste-induced effects are not considered. The disruptive events discussed above are placed into four geologic settings. Although the geology is not specific to given repository sites that have been considered by other agencies, the geology has been generalized from actual field data and is, therefore, considered to be physically reasonable. The geologic settings considered are: (1) interior salt domes of the Gulf Coast, (2) bedded salt of southeastern New Mexico, (3) argillaceous rocks of southern Nevanda, and (4) granitic stocks of the Basin and Range Province. Log-normal distributions of permeabilities of rock units are given for each region. Chapters are devoted to: poresity and permeability of natural materials, regional flow patterns, disruptive events (faulting, dissolution of rock forming minerals, fracturing from various causes, rapid changes of hydraulic regimen); possible hydrologic effects of disruptive events; and hydraulic fracturing

  15. Rapid actions of xenoestrogens disrupt normal estrogenic signaling.

    Science.gov (United States)

    Watson, Cheryl S; Hu, Guangzhen; Paulucci-Holthauzen, Adriana A

    2014-03-01

    Some chemicals used in consumer products or manufacturing (e.g. plastics, surfactants, pesticides, resins) have estrogenic activities; these xenoestrogens (XEs) chemically resemble physiological estrogens and are one of the major categories of synthesized compounds that disrupt endocrine actions. Potent rapid actions of XEs via nongenomic mechanisms contribute significantly to their disruptive effects on functional endpoints (e.g. cell proliferation/death, transport, peptide release). Membrane-initiated hormonal signaling in our pituitary cell model is predominantly driven by mERα with mERβ and GPR30 participation. We visualized ERα on plasma membranes using many techniques in the past (impeded ligands, antibodies to ERα) and now add observations of epitope proximity with other membrane signaling proteins. We have demonstrated a range of rapid signals/protein activations by XEs including: calcium channels, cAMP/PKA, MAPKs, G proteins, caspases, and transcription factors. XEs can cause disruptions of the oscillating temporal patterns of nongenomic signaling elicited by endogenous estrogens. Concentration effects of XEs are nonmonotonic (a trait shared with natural hormones), making it difficult to design efficient (single concentration) toxicology tests to monitor their harmful effects. A plastics monomer, bisphenol A, modified by waste treatment (chlorination) and other processes causes dephosphorylation of extracellular-regulated kinases, in contrast to having no effects as it does in genomic signaling. Mixtures of XEs, commonly found in contaminated environments, disrupt the signaling actions of physiological estrogens even more severely than do single XEs. Understanding the features of XEs that drive these disruptive mechanisms will allow us to redesign useful chemicals that exclude estrogenic or anti-estrogenic activities. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Disruptive behavior in the workplace: Challenges for gastroenterology fellows.

    Science.gov (United States)

    Srisarajivakul, Nalinee; Lucero, Catherine; Wang, Xiao-Jing; Poles, Michael; Gillespie, Colleen; Zabar, Sondra; Weinshel, Elizabeth; Malter, Lisa

    2017-05-14

    To assess first-year gastroenterology fellows' ability to address difficult interpersonal situations in the workplace using objective structured clinical examinations (OSCE). Two OSCEs ("distracted care team" and "frazzled intern") were created to assess response to disruptive behavior. In case 1, a fellow used a colonoscopy simulator while interacting with a standardized patient (SP), nurse, and attending physician all played by actors. The nurse and attending were instructed to display specific disruptive behavior and disregard the fellow unless requested to stop the disruptive behavior and focus on the patient and procedure. In case 2, the fellow was to calm an intern managing a patient with massive gastrointestinal bleeding. The objective in both scenarios was to assess the fellows' ability to perform their duties while managing the disruptive behavior displayed by the actor. The SPs used checklists to rate fellows' performances. The fellows completed a self-assessment survey. Twelve fellows from four gastrointestinal fellowship training programs participated in the OSCE. In the "distracted care team" case, one-third of the fellows interrupted the conflict and refocused attention to the patient. Half of the fellows were able to display professionalism despite the heated discussion nearby. Fellows scored lowest in the interprofessionalism portion of post-OSCE surveys, measuring their ability to handle the conflict. In the "frazzled intern" case, 68% of fellows were able to establish a calm and professional relationship with the SP. Despite this success, only half of the fellows were successfully communicate a plan to the SP and only a third scored "well done" in a domain that focused on allowing the intern to think through the case with the fellow's guidance. Fellows must receive training on how to approach disruptive behavior. OSCEs are a tool that can assess fellow skills and set a culture for open discussion.

  17. Attractant and disruptant semiochemicals for Dendroctonus jeffreyi (Coleoptera: Curculionidae: Scolytinae).

    Science.gov (United States)

    Strom, B L; Smith, S L; Brownie, C

    2013-04-01

    Jeffrey pine, Pinus jeffreyi Greville and Balfour, is a dominant yellow pine and important overstory component of forests growing on diverse sites from southwestern Oregon to Baja California to western Nevada. The Jeffrey pine beetle, Dendroctonus jeffreyi Hopkins (Coleoptera: Curculionidae: Scolytinae), is monophagous on Jeffrey pine and its primary insect pest. Despite the importance of P. jeffreyi, difficult terrain, environmental concerns, and lack of roads can constrain pest management activities. Semiochemicals are often easier to apply and more environmentally acceptable than other options, but they are lacking in this system. Attractants have been identified, but field bioassays have been limited because of infrequent or short duration outbreaks and a lack of beetles during nonoutbreak periods. Disruptant semiochemicals have not been assessed for D. jeffreyi during outbreak conditions; however, commercially available semiochemicals have been implicated as disruptants for this bark beetle. The objective of this study was to identify the most effective commercially available attractant and disruptant semiochemicals for D. jeffreyi. Our highest observed catch occurred with the blend of 5% 1-heptanol and 95% n-heptane. When this was used to challenge potential disruptant semiochemicals, the combination of S-(-)-verbenone and the green leaf volatile blend (cis-3-Hexenol and 1-Hexanol) reduced trap catch by ≍80%. However, frontalin was most effective, reducing the number of D. jeffreyi caught by >96%. Within each year of the study, the percentage female of D. jeffreyi caught with our attractant decreased from start to end of the experimental period. On average, our first collection in a year (mid-June to early July) was 59% female, whereas our last (mid-August) was 34%. Frontalin was equally or more effective against females (the pioneering sex) than males, providing optimism that semiochemical disruption may be possible for protecting Jeffrey pines from D

  18. Evaluation of potential runaway generation in large-tokamak disruptions

    Energy Technology Data Exchange (ETDEWEB)

    Fleischmann, H.H.; Zweben, S.J. (Princeton Univ., NJ (United States). Plasma Physics Lab. Cornell Univ., Ithaca, NY (United States). School of Applied and Engineering Physics)

    1993-06-01

    A detailed evaluation of various potential mechanisms for the generation of strong runaway beams during disruptions of largetokamak devices, including TFTR, JET, DIIID and ITER, is performed based on typical operating parameters of these devices and the presently accepted disruption model. The main results include: (1) In the existing devices, the evaporative preicer'' process by itself can lead to sizable runaway beams in disruptions of high-current-medium-to-low-ne discharges. In ITER, such runaways are expected mainly for discharges with ne values sizably smaller than the projected typical ones. (2) Runaway generation also may occur during post-thermal-quench period through the untrapping of trapped hot-thermal electrons remaining from the pre-thermal-quench plasma; this process may be directly important in particular in disruptions of high-T[sub e] discharges with details depending on the time required for reclosure of the magnetic surfaces. Both processes (1) and (2) will occur and be completed mostly during the initial few 100 [mu]sec after the thermal quench. (3) Subsequently, close collisions of runaways with cold plasma electrons generally will lead to an exponential growth ( avalanching'') of runaway populations generated by processes (1) and/or (2) and/or others; this process will be effective in particular during the current quench phase and will continue until the resulting runaway beam will carry essentially all of the remaining discharge current. In presently existing devices, possible avalanche factors of up to 10[sup 2]--10[sup 5] may be expected; in ITER, avalanche factors of up to 10[sup 10]--10[sup 15] -- if not properly suppressed -- are expected to lead to strong runaway beams in most disruptions, except those at particularly high densities. At the same time, avalanching will shift the main part of their energy spectrum down to relatively low energies around 10--20 MeV, and may sizably change the spatial distribution of the

  19. Evaluation of potential runaway generation in large-tokamak disruptions

    Energy Technology Data Exchange (ETDEWEB)

    Fleischmann, H.H.; Zweben, S.J. [Princeton Univ., NJ (United States). Plasma Physics Lab.]|[Cornell Univ., Ithaca, NY (United States). School of Applied and Engineering Physics

    1993-06-01

    A detailed evaluation of various potential mechanisms for the generation of strong runaway beams during disruptions of largetokamak devices, including TFTR, JET, DIIID and ITER, is performed based on typical operating parameters of these devices and the presently accepted disruption model. The main results include: (1) In the existing devices, the evaporative ``preicer`` process by itself can lead to sizable runaway beams in disruptions of high-current-medium-to-low-ne discharges. In ITER, such runaways are expected mainly for discharges with ne values sizably smaller than the projected typical ones. (2) Runaway generation also may occur during post-thermal-quench period through the untrapping of trapped hot-thermal electrons remaining from the pre-thermal-quench plasma; this process may be directly important in particular in disruptions of high-T{sub e} discharges with details depending on the time required for reclosure of the magnetic surfaces. Both processes (1) and (2) will occur and be completed mostly during the initial few 100 {mu}sec after the thermal quench. (3) Subsequently, close collisions of runaways with cold plasma electrons generally will lead to an exponential growth (``avalanching``) of runaway populations generated by processes (1) and/or (2) and/or others; this process will be effective in particular during the current quench phase and will continue until the resulting runaway beam will carry essentially all of the remaining discharge current. In presently existing devices, possible avalanche factors of up to 10{sup 2}--10{sup 5} may be expected; in ITER, avalanche factors of up to 10{sup 10}--10{sup 15} -- if not properly suppressed -- are expected to lead to strong runaway beams in most disruptions, except those at particularly high densities. At the same time, avalanching will shift the main part of their energy spectrum down to relatively low energies around 10--20 MeV, and may sizably change the spatial distribution of the runaways.

  20. Disruption of conditioned reward association by typical and atypical antipsychotics.

    Science.gov (United States)

    Danna, C L; Elmer, G I

    2010-07-01

    Antipsychotic drugs are broadly classified into typical and atypical compounds; they vary in their pharmacological profile however a common component is their antagonist effects at the D2 dopamine receptors (DRD2). Unfortunately, diminished DRD2 activation is generally thought to be associated with the severity of neuroleptic-induced anhedonia. The purpose of this study was to determine the effect of the atypical antipsychotic olanzapine and typical antipsychotic haloperidol in a paradigm that reflects the learned transfer of incentive motivational properties to previously neutral stimuli, namely autoshaping. In order to provide a dosing comparison to a therapeutically relevant endpoint, both drugs were tested against amphetamine-induced disruption of prepulse inhibition as well. In the autoshaping task, rats were exposed to repeated pairings of stimuli that were differentially predictive of reward delivery. Conditioned approach to the reward-predictive cue (sign-tracking) and to the reward (goal-tracking) increased during repeated pairings in the vehicle treated rats. Haloperidol and olanzapine completely abolished this behavior at relatively low doses (100microg/kg). This same dose was the threshold dose for each drug to antagonize the sensorimotor gating deficits produced by amphetamine. At lower doses (3-30microg/kg) both drugs produced a dose-dependent decrease in conditioned approach to the reward-predictive cue. There was no difference between drugs at this dose range which indicates that olanzapine disrupts autoshaping at a significantly lower proposed DRD2 receptor occupancy. Interestingly, neither drug disrupted conditioned approach to the reward at the same dose range that disrupted conditioned approach to the reward-predictive cue. Thus, haloperidol and olanzapine, at doses well below what is considered therapeutically relevant, disrupts the attribution of incentive motivational value to previously neutral cues. Drug effects on this dimension of reward

  1. Tributyltin: Advancing the science on assessing endocrine disruption with an unconventional endocrine-disrupting compound

    Science.gov (United States)

    Lagadic, Laurent; Katsiadaki, Ioanna; Biever, Ronald C.; Guiney, Patrick; Karouna-Renier, Natalie; Schwarz, Tamar; Meador, James P.

    2018-01-01

    Tributyltin (TBT) has been recognized as an endocrine disrupting chemical (EDC) for several decades. However, only in the last decade, was its primary endocrine mechanism of action (MeOA) elucidated—interactions with the nuclear retinoid-X receptor (RXR), peroxisome proliferator-activated receptor γ (PPARγ), and their heterodimers. This molecular initiating event (MIE) alters a range of reproductive, developmental, and metabolic pathways at the organism level. It is noteworthy that a variety of MeOAs have been proposed over the years for the observed endocrine-type effects of TBT; however, convincing data for the MIE was provided only recently and now several researchers have confirmed and refined the information on this MeOA. One of the most important lessons learned from years of research on TBT concerns apparent species sensitivity. Several aspects such as the rates of uptake and elimination, chemical potency, and metabolic capacity are all important for identifying the most sensitive species for a given chemical, including EDCs. For TBT, much of this was discovered by trial and error, hence important relationships and important sensitive taxa were not identified until several decades after its introduction to the environment. As recognized for many years, TBT-induced responses are known to occur at very low concentrations for molluscs, a fact that has more recently also been observed in fish species. This review explores the MeOA and effects of TBT in different species (aquatic molluscs and other invertebrates, fish, amphibians, birds, and mammals) according to the OECD Conceptual Framework for Endocrine Disruptor Testing and Assessment (CFEDTA). The information gathered on biological effects that are relevant for populations of aquatic animals was used to construct Species Sensitivity Distributions (SSDs) based on No Observed Effect Concentrations (NOECs) and Lowest Observed Effect Concentrations (LOECs). Fish appear at the lower end of these distributions

  2. Where Have the Disruptions Gone? Educational Administration's Theoretical Capacity for Analysing or Fomenting Disruption

    Science.gov (United States)

    Samier, Eugenie A.

    2013-01-01

    Within this essay and the author's reflections on the articles in this special issue, the question considered is: where have all the disruptions gone? On a fundamental level, educational leadership should have something to contribute, since it holds in trust the very educational systems that go a long way to producing the human condition, and…

  3. Tidal Disruption of Phobos as the Cause of Surface Fractures

    Science.gov (United States)

    Hurford, T. A.; Asphaug, E.; Spitale, J. N.; Hemingway, D.; Rhoden, A. R.; Henning, W. G.; Bills, B. G.; Kattenhorn, S. A.; Walker, M.

    2016-01-01

    Phobos, the innermost satellite of Mars, displays an extensive system of grooves that are mostly symmetric about its sub-Mars point. Phobos is steadily spiraling inward due to the tides it raises on Mars lagging behind Phobos' orbital position and will suffer tidal disruption before colliding with Mars in a few tens of millions of years. We calculate the surface stress field of the deorbiting satellite and show that the first signs of tidal disruption are already present on its surface. Most of Phobos' prominent grooves have an excellent correlation with computed stress orientations. The model requires a weak interior that has very low rigidity on the tidal evolution time scale, overlain by an approximately 10-100 m exterior shell that has elastic properties similar to lunar regolith as described by Horvath et al. (1980).

  4. Phenanthrenequinone disrupts progesterone production in rat luteal cells.

    Science.gov (United States)

    Nykamp, J A; Bols, N C; Carlson, J C

    2001-01-01

    The ability of the environmental contaminant phenanthrene (PH) and its photooxidized product phenanthrenequinone (PHQ) to disrupt progesterone secretion was examined in a model system of in vitro suspensions of luteal cells from the rat. Treatment with PHQ dramatically inhibited luteinizing hormone (LH) stimulated progesterone secretion. PHQ also generated a significant increase in reactive oxygen species (ROS). In the absence of LH, however, PHQ stimulated a small increase in basal progesterone secretion. The parent compound, PH, did not alter progesterone or ROS release. Since there is evidence that PHQ lowers the activity of nitric oxide synthase (NOS) and that nitric oxide (NO) affects progesterone production, we examined the response to the NOS inhibitors N-monomethyl-L-arginine, Zn protoporphyrin-9, and aminoguanidine in luteal cells. However, there was no effect of these agents on LH stimulated progesterone secretion. These results indicated that PHQ is a potent disrupter of progesterone secretion and should perhaps be considered in assessing the risk of PH to humans.

  5. [Dialectical behavior therapy approaches with disruptive behavior disorders].

    Science.gov (United States)

    Stadler, Christina; Manetsch, Madleina; Vriends, Noortje

    2016-11-01

    Disruptive behaviour disorders comprise the diagnosis conduct disorder (CD) and in adults the diagnosis antisocial personality disorder (APD). CD is seen as a difficult-to-treat disorder with a high risk for persistent behavioral problems. In addition, CD is seen as the precursor to antisocial personality disorder (Kretschmer et al., 2014). Dialectical behavior therapy (DBT) was originally developed by Marsha Linehan (1991) for the treatment of borderline personality disorder, but because of the core deficits in emotion regulation in disruptive behavior disorders, DBT is also increasingly being recommended for the treatment of CD and APD. This review presents DBT adaptions for the forensic setting and for the treatment of CD/APD. Clinical implications are discussed.

  6. Endocrine disrupting chemicals: harmful substances and how to test them

    Directory of Open Access Journals (Sweden)

    Olea-Serrano Nicolás

    2002-01-01

    Full Text Available This paper presents an analysis of the opinions of different groups from: scientists, international regulatory bodies, non-governmental organizations and industry; with an interest in the problem of identifying chemical substances with endocrine disrupting activity. There is also discussion of the consequences that exposure to endocrine disruptors may have for human health, considering concrete issues related to: the estimation of risk; the tests that must be used to detect endocrine disruption; the difficulties to establish an association between dose, time of exposure, individual susceptibility, and effect; and the attempts to create a census of endocrine disruptors. Finally, it is proposed that not all hormonal mimics should be included under the single generic denomination of endocrine disruptors.

  7. Disruption of gut homeostasis by opioids accelerates HIV disease progression

    Directory of Open Access Journals (Sweden)

    Jingjing eMeng

    2015-06-01

    Full Text Available Cumulative studies during the past 30 years have established the correlation between opioid abuse and human immunodeficiency virus (HIV infection. Further studies also demonstrate that opioid addiction is associated with faster progression to AIDS in patients. Recently, it was revealed that disruption of gut homeostasis and subsequent microbial translocation play important roles in pathological activation of the immune system during HIV infection and contributes to accelerated disease progression. Similarly, opioids have been shown to modulate gut immunity and induce gut bacterial translocation. This review will explore the mechanisms by which opioids accelerate HIV disease progression by disrupting gut homeostasis. Better understanding of these mechanisms will facilitate the search for new therapeutic interventions to treat HIV infection especially in opioid abusing population.

  8. Endocrine-disrupting chemicals and the regulation of energy balance.

    Science.gov (United States)

    Nadal, Angel; Quesada, Ivan; Tudurí, Eva; Nogueiras, Rubén; Alonso-Magdalena, Paloma

    2017-09-01

    Energy balance involves the adjustment of food intake, energy expenditure and body fat reserves through homeostatic pathways. These pathways include a multitude of biochemical reactions, as well as hormonal cues. Dysfunction of this homeostatic control system results in common metabolism-related pathologies, which include obesity and type 2 diabetes mellitus. Metabolism-disrupting chemicals (MDCs) are a particular class of endocrine-disrupting chemicals that affect energy homeostasis. MDCs affect multiple endocrine mechanisms and thus different cell types that are implicated in metabolic control. MDCs affect gene expression and the biosynthesis of key enzymes, hormones and adipokines that are essential for controlling energy homeostasis. This multifaceted spectrum of actions precludes compensatory responses and favours metabolic disorders. Herein, we review the main mechanisms used by MDCs to alter energy balance. This work should help to identify new MDCs, as well as novel targets of their action.

  9. Simulating economic effects of disruptions in the telecommunications infrastructure.

    Energy Technology Data Exchange (ETDEWEB)

    Cox, Roger Gary; Barton, Dianne Catherine; Reinert, Rhonda K.; Eidson, Eric D.; Schoenwald, David Alan

    2004-01-01

    CommAspen is a new agent-based model for simulating the interdependent effects of market decisions and disruptions in the telecommunications infrastructure on other critical infrastructures in the U.S. economy such as banking and finance, and electric power. CommAspen extends and modifies the capabilities of Aspen-EE, an agent-based model previously developed by Sandia National Laboratories to analyze the interdependencies between the electric power system and other critical infrastructures. CommAspen has been tested on a series of scenarios in which the communications network has been disrupted, due to congestion and outages. Analysis of the scenario results indicates that communications networks simulated by the model behave as their counterparts do in the real world. Results also show that the model could be used to analyze the economic impact of communications congestion and outages.

  10. Bird populations as sentinels of endocrine disrupting chemicals

    Directory of Open Access Journals (Sweden)

    Claudio Carere

    2010-03-01

    Full Text Available Exposure to endocrine disrupting chemicals (EDCs is a widespread phenomenon in nature. Although the mechanisms of action of EDCs are actively studied, the consequences of endocrine disruption (ED at the population level and the adaptations evolved to cope with chronic EDC exposure have been overlooked. Birds probably represent the animal taxon most successfully adapted to synanthropic life. Hence, birds share with humans a similar pattern of exposure to xenobiotics. In this article, we review case studies on patterns of behaviour that deviate from the expectation in bird species exposed to EDCs. We provide behavioural and ecological parameters to be used as endpoints of ED; methodological requirements and caveats based on species-specific life-history traits, behavioural repertoires, developmental styles, and possibility of captive breeding; a list of species that could be used as sentinels to assess the quality of man-made environment.

  11. Rare earths: Market disruption, innovation, and global supply chains

    Science.gov (United States)

    Eggert, Roderick; Wadia, Cyrus; Anderson, Corby; Bauer, Diana; Fields, Fletcher; Meinert, Lawrence D.; Taylor, Patrick

    2016-01-01

    Rare earths, sometimes called the vitamins of modern materials, captured public attention when their prices increased more than ten-fold in 2010 and 2011. As prices fell between 2011 and 2016, rare earths receded from public view—but less visibly they became a major focus of innovative activity in companies, government laboratories and universities. Geoscientists worked to better understand the resource base and improve our knowledge about mineral deposits that will be mines in the future. Process engineers carried out research that is making primary production and recycling more efficient. Materials scientists and engineers searched for substitutes that will require fewer or no rare earths while providing properties comparable or superior to those of existing materials. As a result, even though global supply chains are not significantly different now than they were before the market disruption, the innovative activity motivated by the disruption likely will have far-reaching, if unpredictable, consequences for supply chains of rare earths in the future.

  12. Recent Advances on Endocrine Disrupting Effects of UV Filters.

    Science.gov (United States)

    Wang, Jiaying; Pan, Liumeng; Wu, Shenggan; Lu, Liping; Xu, Yiwen; Zhu, Yanye; Guo, Ming; Zhuang, Shulin

    2016-08-03

    Ultraviolet (UV) filters are used widely in cosmetics, plastics, adhesives and other industrial products to protect human skin or products against direct exposure to deleterious UV radiation. With growing usage and mis-disposition of UV filters, they currently represent a new class of contaminants of emerging concern with increasingly reported adverse effects to humans and other organisms. Exposure to UV filters induce various endocrine disrupting effects, as revealed by increasing number of toxicological studies performed in recent years. It is necessary to compile a systematic review on the current research status on endocrine disrupting effects of UV filters toward different organisms. We therefore summarized the recent advances on the evaluation of the potential endocrine disruptors and the mechanism of toxicity for many kinds of UV filters such as benzophenones, camphor derivatives and cinnamate derivatives.

  13. Associations for Disruptiveness: The Pirate Bay vs. Spotify

    Directory of Open Access Journals (Sweden)

    Bjorn Remneland Wikhamn

    2016-10-01

    Full Text Available Most studies on disruptive innovations adopt technology-centric assumptions when explaining how industries are affected by a technology’s creative destruction. This paper argues that the power of a technology lies in how it performatively associates with the cultural and social norms of the wider society. Hence, a technology is not disruptive or sustaining in itself but is potentially a productive outcome of network linkages with other social and material elements. To illustrate this claim, two digital music services will be analyzed, respectively a misfit and a maverick both challenging mainstream providers of music – The Pirate Bay and Spotify – in relation to each other and how they are positioned toward the transformation of the music industry as a whole.

  14. Disruptive Logic Architectures and Technologies From Device to System Level

    CERN Document Server

    Gaillardon, Pierre-Emmanuel; Clermidy, Fabien

    2012-01-01

    This book discusses the opportunities offered by disruptive technologies to overcome the economical and physical limits currently faced by the electronics industry. It provides a new methodology for the fast evaluation of an emerging technology from an architectural perspective and discusses the implications from simple circuits to complex architectures. Several technologies are discussed, ranging from 3-D integration of devices (Phase Change Memories, Monolithic 3-D, Vertical NanoWires-based transistors) to dense 2-D arrangements (Double-Gate Carbon Nanotubes, Sublithographic Nanowires, Lithographic Crossbar arrangements). Novel architectural organizations, as well as the associated tools, are presented in order to explore this freshly opened design space. Describes a novel architectural organization for future reconfigurable systems; Includes a complete benchmarking toolflow for emerging technologies; Generalizes the description of reconfigurable circuits in terms of hierarchical levels; Assesses disruptive...

  15. Endocrine Disruption of Vasopressin Systems and Related Behaviors

    Directory of Open Access Journals (Sweden)

    Heather B. Patisaul

    2017-06-01

    Full Text Available Endocrine disrupting chemicals (EDCs are chemicals that interfere with the organizational or activational effects of hormones. Although the vast majority of the EDC literature focuses on steroid hormone signaling related impacts, growing evidence from a myriad of species reveals that the nonapeptide hormones vasopressin (AVP and oxytocin (OT may also be EDC targets. EDCs shown to alter pathways and behaviors coordinated by AVP and/or OT include the plastics component bisphenol A (BPA, the soy phytoestrogen genistein (GEN, and various flame retardants. Many effects are sex specific and likely involve action at nuclear estrogen receptors. Effects include the elimination or reversal of well-characterized sexually dimorphic aspects of the AVP system, including innervation of the lateral septum and other brain regions critical for social and other non-reproductive behaviors. Disruption of magnocellular AVP function has also been reported in rats, suggesting possible effects on hemodynamics and cardiovascular function.

  16. Symbiotic Gene Activation is Interrupted by Endocrine Disrupting Chemicals

    Directory of Open Access Journals (Sweden)

    Jennifer E. Fox

    2001-01-01

    Full Text Available Endocrine disrupting chemicals (EDCs include organochlorine pesticides, plastics manufacturing by-products, and certain herbicides[1]. These chemicals have been shown to disrupt hormonal signaling in exposed wildlife, lab animals, and mammalian cell culture by binding to estrogen receptors (ER-α and ER-β and affecting the expression of estrogen responsive genes[2,3]. Additionally, certain plant chemicals, termed phytoestrogens, are also able to bind to estrogen receptors and modulate gene expression, and as such also may be considered EDCs[4]. One example of phytoestrogen action is genistein, a phytochemical produced by soybeans, binding estrogen receptors, and changing expression of estrogen responsive genes which certain studies have linked to a lower incidence of hormonally related cancers in Japanese populations[5]. Why would plants make compounds that are able to act as estrogens in the human body? Obviously, soybeans do not intentionally produce phytoestrogens to prevent breast cancer in Japanese women.

  17. Radiation protection criteria for cases of probabilistic disruptive events

    International Nuclear Information System (INIS)

    Beninson, D.J.

    1985-01-01

    The individual risk limitation for the case of probabilistic disruptive events is studied, when the radiation effects cease to be only stochastic; the proposed criterion is applied for the case of high level waste repositories. The protection's optimization results from the differential cost-benefit. More general procedures of decision theory that use probabilistically defined utility functions are considered for its calculation. These more general procedures can be applied also in cases where radiation exposures are only potential, to optimize the required level of safety features. It is shown that for disruptive events of low probability and large resulting consequences, the concept of 'expectation' of consequence can not be used in decision making, but that the use of probabilistically based utility functions can conceptually assure a consistent approach in deciding the required level of safety. The use of utility functions of logaritmic form to assign weights to consequences involving different loss of life is explored (M.E.L.) [es

  18. Recent Advances on Endocrine Disrupting Effects of UV Filters

    Directory of Open Access Journals (Sweden)

    Jiaying Wang

    2016-08-01

    Full Text Available Ultraviolet (UV filters are used widely in cosmetics, plastics, adhesives and other industrial products to protect human skin or products against direct exposure to deleterious UV radiation. With growing usage and mis-disposition of UV filters, they currently represent a new class of contaminants of emerging concern with increasingly reported adverse effects to humans and other organisms. Exposure to UV filters induce various endocrine disrupting effects, as revealed by increasing number of toxicological studies performed in recent years. It is necessary to compile a systematic review on the current research status on endocrine disrupting effects of UV filters toward different organisms. We therefore summarized the recent advances on the evaluation of the potential endocrine disruptors and the mechanism of toxicity for many kinds of UV filters such as benzophenones, camphor derivatives and cinnamate derivatives.

  19. A robust transfer inference algorithm for public transport journeys during disruptions

    NARCIS (Netherlands)

    Yap, M.D.; Cats, O.; van Oort, N.; Hoogendoorn, S.P.

    2017-01-01

    Disruptions in public transport have major impact on passengers and disproportional effects on passenger satisfaction. The availability of smart card data gives opportunities to better quantify disruption impacts on passengers’ experienced journey travel time and comfort. For this, accurate journey

  20. Evaluating research for disruptive innovation in the space sector

    Science.gov (United States)

    Summerer, L.

    2012-12-01

    Many governmental space activities need to be planned with a time horizon that extends beyond the comfort zone of reliable technology development assessments and predictions. In an environment of accelerating technological change, a methodological approach to addressing non-core technology trends and potentially disruptive, game-changing developments not yet linked to the space sector is increasingly important to complement efforts in core technology R&D planning. Various models and organisational setups aimed at fulfilling this purpose are in existence. These include, with varying levels of relevance to space, the National Aeronautics and Space Administration (NASA) Institute for Advanced Concepts (NIAC, operational form 1998 to 2007 and recently re-established), the Defence Advanced Research Projects Agency of the US Department of Defence, the Massachusetts Institute of Technology (MIT) Medialab, the early versions of Starlab, the Lockheed Skunk Works and the European Space Agency's Advanced Concepts Team. Some of these organisations have been reviewed and assessed individually, though systematic comparison of their methods, approaches and results have not been published. This may be due in part to the relatively sparse scientific literature on organisational parameters for enabling disruptive innovation as well as to the lack of commonly agreed indicators for the evaluation of their performance. Furthermore, innovation support systems in the space sector are organised differently than in traditional, open competitive markets, which serve as the basis for most scholarly literature on the organisation of innovation. The present paper is intended to advance and stimulate discussion on the organisation of disruptive innovation mechanisms specifically for the space sector. It uses the examples of the NASA Institute for Advanced Concepts and the ESA Advanced Concepts Team, analyses their respective approaches and compares their results, leading to the proposal of

  1. Elektromobilität: Ist das Elektrofahrzeug eine disruptive Innovation?

    OpenAIRE

    Schneider, Andreas; Grösser, Stefan N.

    2013-01-01

    Seit mehreren Jahren werden das Elektrofahrzeug und seine Auswirkungen auf die Automobilindustrie in der breiten Öffentlichkeit diskutiert. Welten wird dabei die Tatsache angesprochen, dass es sich beim Elektrofahrzeug um eine sogenannte "disruptive Innovation" handeln könnte. Frühere Beispiele disruptiver Innovationen, wie z.B. die Digitalkamera, zeigen, dass diese Innovationen die Spielregeln einer Industrie meist nachhaltig verändern. Hat das Elektrofahrzeug ebenfalls ein solchen disruptiv...

  2. Formation and termination of runaway beams in ITER disruptions

    Science.gov (United States)

    Martín-Solís, J. R.; Loarte, A.; Lehnen, M.

    2017-06-01

    A self-consistent analysis of the relevant physics regarding the formation and termination of runaway beams during mitigated disruptions by Ar and Ne injection is presented for selected ITER scenarios with the aim of improving our understanding of the physics underlying the runaway heat loads onto the plasma facing components (PFCs) and identifying open issues for developing and accessing disruption mitigation schemes for ITER. This is carried out by means of simplified models, but still retaining sufficient details of the key physical processes, including: (a) the expected dominant runaway generation mechanisms (avalanche and primary runaway seeds: Dreicer and hot tail runaway generation, tritium decay and Compton scattering of γ rays emitted by the activated wall), (b) effects associated with the plasma and runaway current density profile shape, and (c) corrections to the runaway dynamics to account for the collisions of the runaways with the partially stripped impurity ions, which are found to have strong effects leading to low runaway current generation and low energy conversion during current termination for mitigated disruptions by noble gas injection (particularly for Ne injection) for the shortest current quench times compatible with acceptable forces on the ITER vessel and in-vessel components ({τ\\text{res}}∼ 22~\\text{ms} ). For the case of long current quench times ({τ\\text{res}}∼ 66~\\text{ms} ), runaway beams up to  ∼10 MA can be generated during the disruption current quench and, if the termination of the runaway current is slow enough, the generation of runaways by the avalanche mechanism can play an important role, increasing substantially the energy deposited by the runaways onto the PFCs up to a few hundreds of MJs. Mixed impurity (Ar or Ne) plus deuterium injection proves to be effective in controlling the formation of the runaway current during the current quench, even for the longest current quench times, as well as in decreasing

  3. Measuring the Welfare Losses from Urban Water Supply Disruptions

    OpenAIRE

    Steven Buck; Maximilian Auffhammer; Stephen Hamilton; David Sunding

    2015-01-01

    The paper evaluates welfare losses from urban water supply disruptions. The analysis incorporates important features of the water industry that may cause the initial allocation of water to be inefficient, namely that ther are a large number of retail-level water utilities, and that mosst water utilities engage in a form of average cost pricing where volumetric rates are used to finance fixed expenses. We consider a sample of 53 urban water utilities in California collectively providing servic...

  4. The Effect of Personal Financing Disruptions on Entrepreneurship

    DEFF Research Database (Denmark)

    Hanspal, Tobin

    Credit market disruptions have been shown to affect business lending and the borrowingbehavior of firms. For small businesses however, financing is most often suppliedby the owner’s assets and debt financing from personal loans. This paper studies howidiosyncratic financing shocks experienced....... Personal wealth changes from investment losses strongly reduce the rateof entrepreneurial survival, especially for less experienced small business owners. Inaddition, personal losses have large effects on the intensive margin, as firm ownerssignificantly reduce employed staff. My results suggest...

  5. Reversed Procrastination by Focal Disruption of Medial Frontal Cortex.

    Science.gov (United States)

    Jha, Ashwani; Diehl, Beate; Scott, Catherine; McEvoy, Andrew W; Nachev, Parashkev

    2016-11-07

    An enduring puzzle in the neuroscience of voluntary action is the origin of the remarkably wide dispersion of the reaction time distribution, an interval far greater than is explained by synaptic or signal transductive noise [1, 2]. That we are able to change our planned actions-a key criterion of volition [3]-so close to the time of their onset implies decision-making must reach deep into the execution of action itself [4-6]. It has been influentially suggested the reaction time distribution therefore reflects deliberate neural procrastination [7], giving alternative response tendencies sufficient time for fair competition in pursuing a decision threshold that determines which one is behaviorally manifest: a race model, where action selection and execution are closely interrelated [8-11]. Although the medial frontal cortex exhibits a sensitivity to reaction time on functional imaging that is consistent with such a mechanism [12-14], direct evidence from disruptive studies has hitherto been lacking. If movement-generating and movement-delaying neural substrates are closely co-localized here, a large-scale lesion will inevitably mask any acceleration, for the movement itself could be disrupted. Circumventing this problem, here we observed focal intracranial electrical disruption of the medial frontal wall in the context of the pre-surgical evaluation of two patients with epilepsy temporarily reversing such hypothesized procrastination. Effector-specific behavioral acceleration, time-locked to the period of electrical disruption, occurred exclusively at a specific locus at the ventral border of the pre-supplementary motor area. A cardinal prediction of race models of voluntary action is thereby substantiated in the human brain. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. Pheromone mating disruption offers selective management options for key pests

    OpenAIRE

    Welter, Stephen C.; Pickel, Carolyn; Millar, Jocelyn; Cave, Frances; Van Steenwyk, Robert A.; Dunley, John

    2005-01-01

    The direct management of insect pests using pheromones for mating disruption, or “attract and kill” approaches, can provide excellent suppression of key lepidopteran pests in agriculture. Important successes to date include codling moth in pome fruit, oriental fruit moth in peaches and nectarines, tomato pinworm in vegetables, pink bollworm in cotton and omnivorous leafroller in vineyards. Large-scale implementation projects have yielded significant reductions in pesticide use while maintaini...

  7. Disruptive innovations for designing and diffusing evidence-based interventions.

    Science.gov (United States)

    Rotheram-Borus, Mary Jane; Swendeman, Dallas; Chorpita, Bruce F

    2012-09-01

    Evidence-based therapeutic and preventive intervention programs (EBIs) have been growing exponentially. Yet EBIs have not been broadly adopted in the United States. In order for our EBI science to significantly reduce disease burden, we need to critically reexamine our scientific conventions and norms. Innovation may be spurred by reexamining the traditional biomedical model for validating, implementing, and diffusing EBI products and science. The model of disruptive innovations suggests that we reengineer EBIs on the basis of their most robust features in order to serve more people in less time and at lower cost. A disruptive innovation provides a simpler and less expensive alternative that meets the essential needs for the majority of consumers and is more accessible, scalable, replicable, and sustainable. Examples of disruptive innovations from other fields include minute clinics embedded in retail chain drug stores, $2 generic eyeglasses, automated teller machines, and telemedicine. Four new research approaches will be required to support disruptive innovations in EBI science: synthesize common elements across EBIs; experiment with new delivery formats (e.g., consumer controlled, self-directed, brief, paraprofessional, coaching, and technology and media strategies); adopt market strategies to promote and diffuse EBI science, knowledge, and products; and adopt continuous quality improvement as a research paradigm for systematically improving EBIs, based on ongoing monitoring data and feedback. EBI science can have more impact if it can better leverage what we know from existing EBIs in order to inspire, engage, inform, and support families and children to adopt and sustain healthy daily routines and lifestyles. (PsycINFO Database Record (c) 2012 APA, all rights reserved).

  8. Runaway beam studies during disruptions at JET-ILW

    Czech Academy of Sciences Publication Activity Database

    Reux, C.; Plyusnin, V.; Alper, B.; Alves, D.; Bazylev, B.; Belonohy, E.; Brezinsek, S.; Decker, J.; Devaux, S.; de Vries, P.; Fil, A.; Gerasimov, S.; Lupelli, I.; Jachmich, S.; Khilkevitch, E.M.; Kiptily, V.; Koslowski, R.; Kruezi, U.; Lehnen, M.; Manzanares, A.; Mlynář, Jan; Nardon, E.; Nilsson, E.; Riccardo, V.; Saint-Laurent, F.; Shevelev, A.E.; Sozzi, C.

    2015-01-01

    Roč. 463, August (2015), s. 143-149 ISSN 0022-3115. [PLASMA-SURFACE INTERACTIONS 21: International Conference on Plasma-Surface Interactions in Controlled Fusion Devices. Kanazawa, 26.05.2014-30.05.2014] Institutional support: RVO:61389021 Keywords : tokamak * JET * runaway electrons * disruptions * ILW Subject RIV: JF - Nuclear Energetics OBOR OECD: Nuclear related engineering Impact factor: 2.199, year: 2015 http://www.sciencedirect.com/science/article/pii/S0022311514006850

  9. Bile acids cycle disruption in patients with nasopharyngeal ...

    African Journals Online (AJOL)

    2014-12-31

    Dec 31, 2014 ... Cite as: Wang C-S, Liu S-H, Peng J, Tang C, Zhu W-G. Bile acids cycle disruption in patients .... stein-Barr virus in the development of nasopharyngeal carcinoma. Chin. J. Cancer 2014; 33(11): 556 PubMed. -568. 2. Mrizak D, Martin N, Barjon C, Jimenez-Pailhes AS,. Mustapha R, Niki T, Guigay J, Pancre V, ...

  10. Aerosol emitters disrupt codling moth, Cydia pomonella, competitively.

    Science.gov (United States)

    McGhee, Peter S; Gut, Larry J; Miller, James R

    2014-12-01

    Isomate(®) CM MIST aerosol emitters (Pacific BioControl Corp, Vancouver, WA) containing 36 g of codlemone, (E,E)-8,10-dodecadien-1-ol, were deployed at various densities in a commercial apple orchard to generate dosage-response profiles in order to elucidate the behavioral mechanism of disruption. Moth captures decreased asymptotically as Isomate(®) CM MIST densities increased. Data fitting to Miller-Gut and Miller-de Lame plots yielded straight lines, with positive and negative slopes respectively. Catch of male moths decreased from 28 trap(-1) in the control to 0.9 trap(-1) at the highest emitter density. Disruption of >90% was realized at emitter densities greater than 5 units ha(-1) . The resulting set of profiles explicitly matched the predictions for competitive rather than non-competitive disruption. Thus, these devices probably disrupt by inducing false-plume following rather than by camouflaging traps and females. The use of 5 MIST units ha(-1) would be necessary to achieve the same level of codling moth control provided by a standard pheromone treatment with passive reservoir dispensers. The need for only a few aerosol emitters, 2.5-5 units ha(-1) , mitigates the cost of labor required to hand-apply hundreds of passive reservoir dispensers; however, a potential weakness in using this technology is that the low deployment density may leave areas of little or no pheromone coverage, where mate finding may occur. This technology is likely to benefit substantially from treatment of large contiguous blocks of crop. © 2014 Society of Chemical Industry.

  11. Computational model of surface ablation from tokamak disruptions

    International Nuclear Information System (INIS)

    Ehst, D.; Hassanein, A.

    1993-10-01

    Energy transfer to material surfaces is dominated by photon radiation through low temperature plasma vapors if tokamak disruptions are due to low kinetic energy particles ( < 100 eV). Simple models of radiation transport are derived and incorporated into a fast-running computer routine to model this process. The results of simulations are in fair agreement with plasma gun erosion tests on several metal targets

  12. Solid-phase synthesis of piperazinones via disrupted Ugi condensation.

    Science.gov (United States)

    Treder, Adam P; Tremblay, Marie-Claude; Yudin, Andrei K; Marsault, Eric

    2014-09-05

    The first application of aziridine aldehyde dimers in solid-phase synthesis is reported. The solid-supported disrupted Ugi condensation between an aziridine aldehyde dimer, isonitrile, and backbone-anchored amino acids delivered N-acyl aziridine intermediates, which were reacted with nucleophiles to yield the corresponding piperazinones. Subsequent cleavage from the resin provided a diverse set of 2,3,6-trisubstituted piperazinones starting from various amino acids, aziridine aldehydes, and nucleophiles.

  13. Disruption of written language in aphasia: a case study.

    Science.gov (United States)

    Freedman-Stern, R; Ulatowska, H K; Baker, T; DeLacoste, C

    1984-07-01

    This study documents the performance of a Wernicke aphasic on production of written discourse. The discourse data consisted of spontaneously produced texts of three different types: narrative discourse, personal and formal letters, and expository discourse. A detailed description of the language of this aphasic at a sentence and discourse level revealed preservation of discourse structure through proper use of cohesive devices despite severe disruption of linguistic structure at a sentence level.

  14. Recent Advances on Endocrine Disrupting Effects of UV Filters

    OpenAIRE

    Wang, Jiaying; Pan, Liumeng; Wu, Shenggan; Lu, Liping; Xu, Yiwen; Zhu, Yanye; Guo, Ming; Zhuang, Shulin

    2016-01-01

    Ultraviolet (UV) filters are used widely in cosmetics, plastics, adhesives and other industrial products to protect human skin or products against direct exposure to deleterious UV radiation. With growing usage and mis-disposition of UV filters, they currently represent a new class of contaminants of emerging concern with increasingly reported adverse effects to humans and other organisms. Exposure to UV filters induce various endocrine disrupting effects, as revealed by increasing number of ...

  15. The effects of endocrine disrupting chemicals on the human organism

    OpenAIRE

    Karolina Kulik-Kupka; Justyna Nowak; Ilona Korzonek-Szlacheta; Barbara Zubelewicz-Szkodzińska

    2017-01-01

    The development of civilization has not only improved the quality of life, but it is also responsible for increasing environmental pollution. Between 80000-100000 previously unknown chemicals have been estimated to circulate in the air. They include substances known as endocrine disrupting chemicals (EDC). These substances can naturally be found in the environment and food, or are classified as pollutants. EDCs are said to change the functionality of the endocrine system and, in this way, exe...

  16. Digital disruption of the banking industry: Threat or opportunity?

    OpenAIRE

    Krstić Nataša; Tešić Dejan

    2016-01-01

    If the previous decade in the banking business was marked by excessive credit expansion, today we are talking about a decade of its digital transformation. Under the influence of digital media and tremendous changes in technology and consumer needs, banks are exposed to digital disruption of their business models both from the inside and outside, which all leads to innovations in products, services, sales and distribution channels, business models and ultimately organizational culture. Sector...

  17. CNES-NASA Disruption-Tolerant Networking (DTN) Interoperability

    Science.gov (United States)

    Mortensen, Dale; Eddy, Wesley M.; Reinhart, Richard C.; Lassere, Francois

    2014-01-01

    Future missions requiring robust internetworking services may use Delay-Disruption-Tolerant Networking (DTN) technology. CNES, NASA, and other international space agencies are committed to using CCSDS standards in their space and ground mission communications systems. The experiment described in this presentation will evaluate operations concepts, system performance, and advance technology readiness for the use of DTN protocols in conjunction with CCSDS ground systems, CCSDS data links, and CCSDS file transfer applications

  18. Optogenetic disruption of sleep continuity impairs memory consolidation

    OpenAIRE

    Rolls, Asya; Colas, Damien; Adamantidis, Antoine; Carter, Matt; Lanre-Amos, Tope; Heller, H. Craig; de Lecea, Luis

    2011-01-01

    Memory consolidation has been proposed as a function of sleep. However, sleep is a complex phenomenon characterized by several features including duration, intensity, and continuity. Sleep continuity is disrupted in different neurological and psychiatric conditions, many of which are accompanied by memory deficits. This finding has raised the question of whether the continuity of sleep is important for memory consolidation. However, current techniques used in sleep research cannot manipulate ...

  19. Enhanced gravitropism of roots with a disrupted cap actin cytoskeleton

    Science.gov (United States)

    Hou, Guichuan; Mohamalawari, Deepti R.; Blancaflor, Elison B.

    2003-01-01

    The actin cytoskeleton has been proposed to be a major player in plant gravitropism. However, understanding the role of actin in this process is far from complete. To address this problem, we conducted an analysis of the effect of Latrunculin B (Lat B), a potent actin-disrupting drug, on root gravitropism using various parameters that included detailed curvature kinetics, estimation of gravitropic sensitivity, and monitoring of curvature development after extended clinorotation. Lat B treatment resulted in a promotion of root curvature after a 90 degrees reorientation in three plant species tested. More significantly, the sensitivity of maize (Zea mays) roots to gravity was enhanced after actin disruption, as determined from a comparison of presentation time of Lat B-treated versus untreated roots. A short 10-min gravistimulus followed by extended rotation on a 1-rpm clinostat resulted in extensive gravitropic responses, manifested as curvature that often exceeded 90 degrees. Application of Lat B to the cap or elongation zone of maize roots resulted in the disruption of the actin cytoskeleton, which was confined to the area of localized Lat B application. Only roots with Lat B applied to the cap displayed the strong curvature responses after extended clinorotation. Our study demonstrates that disrupting the actin cytoskeleton in the cap leads to the persistence of a signal established by a previous gravistimulus. Therefore, actin could function in root gravitropism by providing a mechanism to regulate the proliferation of a gravitropic signal originating from the cap to allow the root to attain its correct orientation or set point angle.

  20. High energy neutrinos from the tidal disruption of stars

    International Nuclear Information System (INIS)

    Lunardini, Cecilia

    2017-01-01

    We study the production of high energy neutrinos in jets from the tidal disruption of stars by supermassive black holes. The diffuse neutrino flux expected from these tidal disruption events (TDEs) is calculated both analytically and numerically, taking account the dependence of the rate of TDEs on the redshift and black hole mass. We find that ∝ 10% of the observed diffuse flux at IceCube at an energy of about 1 PeV can come from TDEs if the characteristics of known jetted tidal disruption events are assumed to apply to the whole population of these sources. If, however, plausible scalings of the jet Lorentz factor or variability timescale with the black hole mass are taken into account, the contribution of the lowest mass black holes to the neutrino flux is enhanced. In this case, TDEs can account for most of the neutrino flux detected at IceCube, describing both the neutrino flux normalization and spectral shape with moderate baryonic loadings. While the uncertainties on our assumptions are large, a possible signature of TDEs as the origin of the IceCube signal is the transition of the flux flavor composition from a pion beam to a muon damped source at the highest energies, which will also result in a suppression of Glashow resonance events.

  1. Electronic prescriptions and disruptions to the jurisdiction of community pharmacists.

    Science.gov (United States)

    Motulsky, Aude; Sicotte, Claude; Lamothe, Lise; Winslade, Nancy; Tamblyn, Robyn

    2011-07-01

    The practice of community pharmacists is being challenged by the appearance of electronic prescription (e-Rx) technology. This article examines the disruptions caused by e-Rx technology to the jurisdiction of community pharmacists based on a model developed from work by Abbott (1988). The main disruptions to professional activities were investigated by qualitative methods in a series of interviews with pharmacists and physicians separated in two groups: practitioners who tested a typical e-Rx technology and stakeholders involved in the implementation of this large-scale e-Rx project in Quebec, Canada. The findings suggest that the technology may disrupt the jurisdiction of community pharmacists, mainly by changing the distribution of information among physicians and community pharmacists. More specifically, the technology represents both a threat to community pharmacists - by supporting the dominant position held by physicians if it gives them access to information held exclusively by pharmacists - and an opportunity - by redistributing information to the pharmacists' benefit, allowing them to improve the quality of their inferences about medication. However, it would appear that the opportunities offered by the technology generate concerns and tensions, both between physicians and pharmacists and between the pharmacists themselves. This phenomenon may well work against the implementation and use of available tools. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Endocrine Disruption and In Vitro Ecotoxicology: Recent Advances and Approaches.

    Science.gov (United States)

    Wagner, Martin; Kienle, Cornelia; Vermeirssen, Etiënne L M; Oehlmann, Jörg

    Endocrine-disrupting chemicals (EDCs) are man-made compounds interfering with hormone signaling. Omnipresent in the environment, they can cause adverse effects in a wide range of wildlife. Accordingly, Endocrine Disruption is one focal area of ecotoxicology. Because EDCs induce complex response patterns in vivo via a wide range of mechanisms of action, in vitro techniques have been developed to reduce and understand endocrine toxicity. In this review we revisit the evidence for endocrine disruption in diverse species and the underlying molecular mechanisms. Based on this, we examine the battery of in vitro bioassays currently in use in ecotoxicological research and discuss the following key questions. Why do we use in vitro techniques? What endpoints are we looking at? Which applications are we using in vitro bioassays for? How can we put in vitro data into a broader context? And finally, what is the practical relevance of in vitro data? In critically examining these questions, we review the current state-of-the-art of in vitro (eco)toxicology, highlight important limitations and challenges, and discuss emerging trends and future research needs.

  3. Disrupted Brain Network Hubs in Subtype-Specific Parkinson's Disease.

    Science.gov (United States)

    Ma, Ling-Yan; Chen, Xiao-Dan; He, Yong; Ma, Hui-Zi; Feng, Tao

    2017-01-01

    The topological organization of brain functional networks is impaired in Parkinson's disease (PD). However, the altered patterns of functional network hubs in different subtypes of PD are not completely understood. 3T resting-state functional MRI and voxel-based graph-theory analysis were employed to systematically investigate the intrinsic functional connectivity patterns of whole-brain networks. We enrolled 31 patients with PD (12 tremor dominant [TD] and 19 with postural instability/gait difficulty [PIGD]) and 22 matched healthy controls. Whole-brain voxel-wise functional networks were constructed by measuring the temporal correlations of each pair of brain voxels. Functional connectivity strength was calculated to explore the brain network hubs. We found that both the TD and PIGD subtypes had comprehensive disrupted regions. These mainly involved the basal ganglia, cerebellum, superior temporal gyrus, pre- and postcentral gyri, inferior frontal gyrus, middle temporal gyrus, lingual gyrus, insula, and parahippocampal gyrus. Furthermore, the PIGD subgroup had more disrupted hubs in the cerebellum than the TD subgroup. These disruptions of hub connectivity were not correlated with the HY stage or disease duration. Our results emphasize the subtype-specific PD-related degeneration of brain hubs, providing novel insights into the pathophysiological mechanisms of connectivity dysfunction in different PD subgroups. © 2017 S. Karger AG, Basel.

  4. High energy neutrinos from the tidal disruption of stars

    Energy Technology Data Exchange (ETDEWEB)

    Lunardini, Cecilia [Arizona State Univ., Tempe, AZ (United States). Dept. of Physics; Winter, Walter [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2017-05-17

    We study the production of high energy neutrinos in jets from the tidal disruption of stars by supermassive black holes. The diffuse neutrino flux expected from these tidal disruption events (TDEs) is calculated both analytically and numerically, taking account the dependence of the rate of TDEs on the redshift and black hole mass. We find that ∝ 10% of the observed diffuse flux at IceCube at an energy of about 1 PeV can come from TDEs if the characteristics of known jetted tidal disruption events are assumed to apply to the whole population of these sources. If, however, plausible scalings of the jet Lorentz factor or variability timescale with the black hole mass are taken into account, the contribution of the lowest mass black holes to the neutrino flux is enhanced. In this case, TDEs can account for most of the neutrino flux detected at IceCube, describing both the neutrino flux normalization and spectral shape with moderate baryonic loadings. While the uncertainties on our assumptions are large, a possible signature of TDEs as the origin of the IceCube signal is the transition of the flux flavor composition from a pion beam to a muon damped source at the highest energies, which will also result in a suppression of Glashow resonance events.

  5. The power of disruptive technological innovation: Transcatheter aortic valve implantation.

    Science.gov (United States)

    Berlin, David B; Davidson, Michael J; Schoen, Frederick J

    2015-11-01

    We sought to evaluate the principles of disruptive innovation, defined as technology innovation that fundamentally shifts performance and utility metrics, as applied to transcatheter aortic valve implantation (TAVI). In particular, we considered implantation procedure, device design, cost, and patient population. Generally cheaper and lower performing, classical disruptive innovations are first commercialized in insignificant markets, promise lower margins, and often parasitize existing usage, representing unattractive investments for established market participants. However, despite presently high unit cost, TAVI is less invasive, treats a "new," generally high risk, patient population, and is generally done by a multidisciplinary integrated heart team. Moreover, at least in the short-term TAVI has not been lower-performing than open surgical aortic valve replacement in high-risk patients. We conclude that TAVI extends the paradigm of disruptive innovation and represents an attractive commercial opportunity space. Moreover, should the long-term performance and durability of TAVI approach that of conventional prostheses, TAVI will be an increasingly attractive commercial opportunity. © 2014 Wiley Periodicals, Inc.

  6. Neutronic analysis of LMFBRs during severe core disruptive accidents

    International Nuclear Information System (INIS)

    Tomlinson, E.T.

    1979-01-01

    A number of numerical experiments were performed to assess the validity of diffusion theory and various perturbation methods for calculating the reactivity state of a severely disrupted liquid metal cooled fast breeder reactor (LMFBR). The disrupted configurations correspond, in general, to phases through which an LMFBR core could pass during a core disruptive accident (CDA). Two-reactor models were chosen for this study, the two zone, homogeneous Clinch River Breeder Reactor and the Large Heterogeneous Reactor Design Study Core. The various phases were chosen to approximate the CDA results predicted by the safety analysis code SAS3D. The calculational methods investigated in this study include the eigenvalue difference technique based on both discrete ordinate transport theory and diffusion theory, first-order perturbation theory, exact perturbation theory, and a new hybrid perturbation theory. Selected cases were analyzed using Monte Carlo methods. It was found that in all cases, diffusion theory and perturbation theory yielded results for the change in reactivity that significantly disagreed with both the discrete ordinate and Monte Carlo results. These differences were, in most cases, in a nonconservative direction

  7. A data bank of disruptive discharges in ASDEX

    International Nuclear Information System (INIS)

    Ludescher, C.; Lackner, K.; Schneider, F.

    1994-03-01

    The compilation of data banks relating to plasma disruptions is important for the design of next-step devices and tokamak reactors, as a means of establishing safe operation regimes and assessing the residual risk from such events. ASDEX has an operational history of 33509 plasma shots covering an exceptionally wide range of machine conditions: Divertor/limiter configurations; Ohmic, NBI, ICRH and LH heating; carbonization, boronization wall-conditioning, gas-puff and pellet refuelling. We have compiled a data base of the Disruptive Operationl Regimes in ASDEX (DORA), which contains the relevant information for all ASDEX-discharges and is available on tape and readable by different data bank systems for further evaluation. We first describe the criteria applied to recognize and classify disruptions and the information about them stored in the file. In a second part we use the DORA file for some sample applications of physical or engineering interest. In an appendix we give the data and format information necessary to read the DORA file. (orig.)

  8. Modeling methodology for supply chain synthesis and disruption analysis

    Science.gov (United States)

    Wu, Teresa; Blackhurst, Jennifer

    2004-11-01

    The concept of an integrated or synthesized supply chain is a strategy for managing today's globalized and customer driven supply chains in order to better meet customer demands. Synthesizing individual entities into an integrated supply chain can be a challenging task due to a variety of factors including conflicting objectives, mismatched incentives and constraints of the individual entities. Furthermore, understanding the effects of disruptions occurring at any point in the system is difficult when working toward synthesizing supply chain operations. Therefore, the goal of this research is to present a modeling methodology to manage the synthesis of a supply chain by linking hierarchical levels of the system and to model and analyze disruptions in the integrated supply chain. The contribution of this research is threefold: (1) supply chain systems can be modeled hierarchically (2) the performance of synthesized supply chain system can be evaluated quantitatively (3) reachability analysis is used to evaluate the system performance and verify whether a specific state is reachable, allowing the user to understand the extent of effects of a disruption.

  9. The Influence of Slope Breaks on Lava Flow Surface Disruption

    Science.gov (United States)

    Glaze, Lori S.; Baloga, Stephen M.; Fagents, Sarah A.; Wright, Robert

    2014-01-01

    Changes in the underlying slope of a lava flow impart a significant fraction of rotational energy beyond the slope break. The eddies, circulation and vortices caused by this rotational energy can disrupt the flow surface, having a significant impact on heat loss and thus the distance the flow can travel. A basic mechanics model is used to compute the rotational energy caused by a slope change. The gain in rotational energy is deposited into an eddy of radius R whose energy is dissipated as it travels downstream. A model of eddy friction with the ambient lava is used to compute the time-rate of energy dissipation. The key parameter of the dissipation rate is shown to be rho R(sup 2/)mu, where ? is the lava density and mu is the viscosity, which can vary by orders of magnitude for different flows. The potential spatial disruption of the lava flow surface is investigated by introducing steady-state models for the main flow beyond the steepening slope break. One model applies to slow-moving flows with both gravity and pressure as the driving forces. The other model applies to fast-moving, low-viscosity, turbulent flows. These models provide the flow velocity that establishes the downstream transport distance of disrupting eddies before they dissipate. The potential influence of slope breaks is discussed in connection with field studies of lava flows from the 1801 Hualalai and 1823 Keaiwa Kilauea, Hawaii, and 2004 Etna eruptions.

  10. Initiation of melting and evaporating of materials under plasma disruption

    International Nuclear Information System (INIS)

    Hayashi, Takahiro; Morita, Takeshi; Kozawa, Yoshiyuki; Fujii-e, Yoichi

    1993-01-01

    In a tokamak reactor, a pulsed high heat flux, whose heat flux should result in up to 2 x 10 5 MW/m 2 , would be injected to the plasma facing components (PFCs) due to a plasma disruption. By this heat load the PFCs are melted, evaporated and cracked. In this study melting and evaporation behavior was investigated through performing the experiment with use of an electron beam to simulate heat loads due to plasma disruptions and the numerical and approximate analyses. Experimental and analytical results show that the evaporated mass increases abruptly at a curtain heat flux and time, and that the thickness of melting layer has the maximum at a curtain heat flux. From dimensionless expressions of such results the simple dimensionless correlations between the relevant values were obtained to estimate the significant characteristics such as evaporation thresholds and maximum melting layer thickness. Applying them to evaluation of the thermal resistance of materials against various heat loads due to a plasma disruption confirms that against the milder heat load, the materials whose initiation of melting and evaporation occurs late, such as tungsten, are suitable for armor materials and against the severer heat load, the materials that have a large of latent heat evaporation, such as graphite, are suitable for armor materials. (author)

  11. World oil price behavior during oil supply disruptions: what can we learn from the past

    Energy Technology Data Exchange (ETDEWEB)

    Birdsall, T.H.

    1980-08-01

    The purpose of this paper is to: (1) examine how world oil prices have behaved during past oil supply disruptions, (2) attempt to understand why world oil prices have behaved during disruptions as they have, and (3) see what history foretells, if anything, for the behavior of world oil prices during future oil supply disruptions.

  12. DMPD: What is disrupting IFN-alpha's antiviral activity? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 15283983 What is disrupting IFN-alpha's antiviral activity? Mbow ML, Sarisky RT. Tr...ends Biotechnol. 2004 Aug;22(8):395-9. (.png) (.svg) (.html) (.csml) Show What is disrupting IFN-alpha's ant...iviral activity? PubmedID 15283983 Title What is disrupting IFN-alpha's antiviral activity? Authors Mbow ML,

  13. Opportunity in an Age of Disruption: How Independent Schools Can Lead the Change

    Science.gov (United States)

    Katzman, John; Horn, Michael B.

    2016-01-01

    Technologies used in new business models have disrupted almost every sector of the economy. Many are now beginning to discuss when disruption will come to independent schools. The answer, of course, is that it has already happened; in areas such as admissions, college guidance, and learning content, there are disruptive innovations that are…

  14. Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise

    Directory of Open Access Journals (Sweden)

    Hee-Tae Roh

    2017-06-01

    Conclusion: Our study suggests that episodic vigorous exercise can increase oxidative stress and blood neurotrophic factor levels and induce disruption of the BBB. Moreover, high levels of neurotrophic factor in the blood after exercise in the obese group may be due to BBB disruption, and it is assumed that oxidative stress was the main cause of this BBB disruption.

  15. Emerging Mental Health Diagnoses and School Disruption: An Examination among Clinically Referred Children and Youth

    Science.gov (United States)

    Stewart, Shannon L.; Klassen, Janell; Hamza, Chloe

    2016-01-01

    Previous research linking school disruption with mental health problems has largely relied on assessments of academic achievement to measure school disruption. Early disruptive classroom behaviour (e.g., conflict with school staff, negative attitudes toward school), however, may precipitate poor academic performance and may stem from emerging…

  16. Early Blood-Brain Barrier Disruption after Mechanical Thrombectomy in Acute Ischemic Stroke.

    Science.gov (United States)

    Shi, Zhong-Song; Duckwiler, Gary R; Jahan, Reza; Tateshima, Satoshi; Szeder, Viktor; Saver, Jeffrey L; Kim, Doojin; Sharma, Latisha K; Vespa, Paul M; Salamon, Noriko; Villablanca, J Pablo; Viñuela, Fernando; Feng, Lei; Loh, Yince; Liebeskind, David S

    2018-02-27

    The impact of blood-brain barrier (BBB) disruption can be detected by intraparenchymal hyperdense lesion on the computed tomography (CT) scan after endovascular stroke therapy. The purpose of this study was to determine whether early BBB disruption predicts intracranial hemorrhage and poor outcome in patients with acute ischemic stroke treated with mechanical thrombectomy. We analyzed patients with anterior circulation stroke treated with mechanical thrombectomy and identified BBB disruption on the noncontrast CT images immediately after endovascular treatment. Follow-up CT or magnetic resonance imaging scan was performed at 24 hours to assess intracranial hemorrhage. We dichotomized patients into those with moderate BBB disruption versus those with minor BBB disruption and no BBB disruption. We evaluated the association of moderate BBB disruption after mechanical thrombectomy with intracranial hemorrhage and clinical outcomes. Moderate BBB disruption after mechanical thrombectomy was found in 56 of 210 patients (26.7%). Moderate BBB disruption was independently associated with higher rates of hemorrhagic transformation (OR 25.33; 95% CI 9.93-64.65; P disruption with intracranial hemorrhage remained in patients with successful reperfusion after mechanical thrombectomy. The location of BBB disruption was not associated with intracranial hemorrhage and poor outcome. Moderate BBB disruption is common after mechanical thrombectomy in a quarter of patients with acute ischemic stroke and increases the risk of intracranial hemorrhage and poor outcome. Copyright © 2018 by the American Society of Neuroimaging.

  17. Disruption of the thyroid system by the thyroid-disrupting compound Aroclor 1254 in juvenile Japanese flounder (Paralichthys olivaceus.

    Directory of Open Access Journals (Sweden)

    Yifei Dong

    Full Text Available Polychlorinated biphenyls (PCBs are a group of persistent organochlorine compounds that have the potential to disrupt the homeostasis of thyroid hormones (THs in fish, particularly juveniles. In this study, thyroid histology, plasma TH levels, and iodothyronine deiodinase (IDs, including ID1, ID2, and ID3 gene expression patterns were examined in juvenile Japanese flounder (Paralichthys olivaceus following 25- and 50-day waterborne exposure to environmentally relevant concentrations of a commercial PCB mixture, Aroclor 1254 (10, 100, and 1000 ng/L with two-thirds of the test solutions renewed daily. The results showed that exposure to Aroclor 1254 for 50 d increased follicular cell height, colloid depletion, and hyperplasia. In particular, hypothyroidism, which was induced by the administration of 1000 ng/L Aroclor 1254, significantly decreased plasma TT4, TT3, and FT3 levels. Profiles of the changes in mRNA expression levels of IDs were observed in the liver and kidney after 25 and 50 d PCB exposure, which might be associated with a reduction in plasma THs levels. The expression level of ID2 mRNA in the liver exhibited a dose-dependent increase, indicating that this ID isotype might serve as sensitive and stable indicator for thyroid-disrupting chemical (TDC exposure. Overall, our study confirmed that environmentally relevant concentrations of Aroclor 1254 cause significant thyroid disruption, with juvenile Japanese flounder being suitable candidates for use in TDC studies.

  18. Price competition model in decentralized and centralized supply chains with demand disruption

    Directory of Open Access Journals (Sweden)

    Chai Wenlong

    2013-03-01

    Full Text Available Purpose: The paper studies the price competition of a supply chain with one supplier and two competing retailers under occasional demand disruption.Design/methodology/approach: The supply chain is either decentralized or centralized. The demand disruption for two retailers occurs with different probability. We analyze the effect of occurrence probability of demand disruption on the optimal prices of the supplier and two retailers.Findings: We find that the profits of supplier, retailers and supply chain are decreasing with the occurrence probability of demand disruption.Originality/value: It is helpful for supply chain members to adjust the original contracts to demand disruption.

  19. Disruptive behavior in the operating room: prevalence, consequences, prevention, and management.

    Science.gov (United States)

    Villafranca, Alexander; Fast, Ian; Jacobsohn, Eric

    2018-04-13

    Disruptive workplace behavior can have serious consequences to clinicians, institutions, and patients. There is a range of disruptive behaviors, and the consequences are often underappreciated. The purpose of this manuscript is to review the definition, prevalence, consequences, prevention, and management of disruptive behavior in the operating room. Although a small minority of operating room clinicians act disruptively, 98% of clinicians report having recently been exposed to disruptive behavior, with the average being 64 events per clinician per year. The causes include intrapersonal factors, workplace relationships, workplace logistics, and broader contextual factors. Disruptive behavior undermines patient care by decreasing individual and team clinical performance. It decreases clinician well being, sets a poor example for medical students who are susceptible to negative role models, and decreases hospital efficiency. The way that clinicians respond to disruptive behavior may either exacerbate or reduce the consequences of the behavior. In order to prevent disruptive behavior, the causes must be addressed. Institutions must have robust policies to deal with disruptive behavior and have preventive measures that include regular staff education. Whenever disruptive behavior does occur, it must be expeditiously addressed, which may include graded discipline. Disruptive intraoperative behavior is prevalent and harms multiple parties in the operating room. Institutions require comprehensive measures to prevent the behavior and to mitigate consequences.

  20. Existing Knowledge Assets and Disruptive Innovation: The Role of Knowledge Embeddedness and Specificity

    Directory of Open Access Journals (Sweden)

    Chunpei Lin

    2018-01-01

    Full Text Available Disruptive innovation has created a significant impact on management practices and academia. This study investigated the impact of existing knowledge assets on disruptive innovation by analyzing the role of knowledge embeddedness and specificity. We conducted a hierarchical regression analysis by using survey data from 173 Chinese industrial firms to test the direct and indirect effects of knowledge embeddedness and specificity on disruptive innovation, which can be divided into outward-oriented and internal-oriented disruptive innovation. The results indicated that knowledge embeddedness not only played a positive role in knowledge specificity, but also had a positive effect on outward-oriented disruptive innovation. Furthermore, knowledge specificity exhibited opposite functions in outward-oriented and internal-oriented disruptive innovation. In addition, knowledge specificity mediated the relationship between knowledge embeddedness and outward-oriented (internal-oriented disruptive innovation.

  1. Nonlinear disruption of ecological interactions in response to nitrogen deposition.

    Science.gov (United States)

    Ochoa-Hueso, Raúl

    2016-10-01

    Global environmental change (GEC) is affecting species interactions and causing a rapid decline in biodiversity. In this study, I present a new Ecosystem Disruption Index to quantify the impacts of simulated nitrogen (N) deposition (0, 10, 20, and 50 kg N·ha -1 ·yr -1  + 6-7 kg N·ha -1 ·yr -1 background) on abiotic and biotic ecological interactions. This comparative index is based on pairwise linear and quadratic regression matrices. These matrices, calculated at the N treatment level, were constructed using a range of abiotic and biotic ecosystem constituents: soil pH, shrub cover, and the first component of several separate principal component analyses using soil fertility data (total carbon and N) and community data (annual plants, microorganisms, biocrusts, edaphic fauna) for a total of seven ecosystem constituents. Four years of N fertilization in a semiarid shrubland completely disrupted the network of ecological interactions, with a greater proportional increase in ecosystem disruption at low N addition levels. Biotic interactions, particularly those involving microbes, shrubs, and edaphic fauna, were more prone to be lost in response to N, whereas interactions involving soil properties were more resilient. In contrast, edaphic fauna was the only group directly affected by N addition, with mites and collembolans increasing their abundance with up to 20 kg N·ha -1 ·yr -1 and then decreasing, which supports the idea of higher-trophic-level organisms being more sensitive to disturbance due to more complex links with other ecosystem constituents. Future experimental studies evaluating the impacts of N deposition, and possibly other GEC drivers, on biodiversity and biotic and abiotic interactions may be able to explain results more effectively in the context of ecological networks as a key feature of ecosystem sensitivity. © 2016 by the Ecological Society of America.

  2. Bisphenol a exposure disrupts genomic imprinting in the mouse.

    Directory of Open Access Journals (Sweden)

    Martha Susiarjo

    2013-04-01

    Full Text Available Exposure to endocrine disruptors is associated with developmental defects. One compound of concern, to which humans are widely exposed, is bisphenol A (BPA. In model organisms, BPA exposure is linked to metabolic disorders, infertility, cancer, and behavior anomalies. Recently, BPA exposure has been linked to DNA methylation changes, indicating that epigenetic mechanisms may be relevant. We investigated effects of exposure on genomic imprinting in the mouse as imprinted genes are regulated by differential DNA methylation and aberrant imprinting disrupts fetal, placental, and postnatal development. Through allele-specific and quantitative real-time PCR analysis, we demonstrated that maternal BPA exposure during late stages of oocyte development and early stages of embryonic development significantly disrupted imprinted gene expression in embryonic day (E 9.5 and 12.5 embryos and placentas. The affected genes included Snrpn, Ube3a, Igf2, Kcnq1ot1, Cdkn1c, and Ascl2; mutations and aberrant regulation of these genes are associated with imprinting disorders in humans. Furthermore, the majority of affected genes were expressed abnormally in the placenta. DNA methylation studies showed that BPA exposure significantly altered the methylation levels of differentially methylated regions (DMRs including the Snrpn imprinting control region (ICR and Igf2 DMR1. Moreover, exposure significantly reduced genome-wide methylation levels in the placenta, but not the embryo. Histological and immunohistochemical examinations revealed that these epigenetic defects were associated with abnormal placental development. In contrast to this early exposure paradigm, exposure outside of the epigenetic reprogramming window did not cause significant imprinting perturbations. Our data suggest that early exposure to common environmental compounds has the potential to disrupt fetal and postnatal health through epigenetic changes in the embryo and abnormal development of the

  3. Intracellular Renin Disrupts Chemical Communication between Heart Cells. Pathophysiological Implications.

    Science.gov (United States)

    De Mello, Walmor C

    2014-01-01

    HighlightsIntracellular renin disrupts chemical communication in the heartAngiotensinogen enhances the effect of reninIntracellular enalaprilat reduces significantly the effect of reninIntracellular renin increases the inward calcium currentHarmful versus beneficial effect during myocardial infarction The influence of intracellular renin on the process of chemical communication between cardiac cells was investigated in cell pairs isolated from the left ventricle of adult Wistar Kyoto rats. The enzyme together with Lucifer yellow CH was dialyzed into one cell of the pair using the whole cell clamp technique. The diffusion of the dye in the dialyzed and in non-dialyzed cell was followed by measuring the intensity of fluorescence in both cells as a function of time. The results indicated that; (1) under normal conditions, Lucifer Yellow flows from cell to cell through gap junctions; (2) the intracellular dialysis of renin (100 nM) disrupts chemical communication - an effect enhanced by simultaneous administration of angiotensinogen (100 nM); (3) enalaprilat (10(-9) M) administered to the cytosol together with renin reduced drastically the uncoupling action of the enzyme; (4) aliskiren (10(-8) M) inhibited the effect of renin on chemical communication; (5) the possible role of intracellular renin independently of angiotensin II (Ang II) was evaluated including the increase of the inward calcium current elicited by the enzyme and the possible role of oxidative stress on the disruption of cell communication; (6) the possible harmful versus the beneficial effect of intracellular renin during myocardial infarction was discussed; (7) the present results indicate that intracellular renin due to internalization or in situ synthesis causes a severe impairment of chemical communication in the heart resulting in derangement of metabolic cooperation with serious consequences for heart function.

  4. Gas jet disruption mitigation studies on Alcator C-Mod

    International Nuclear Information System (INIS)

    Granetz, R.; Whyte, D.G.; Izzo, V.A.; Biewer, T.; Reinke, M.L.; Terry, J.; Bader, A.; Bakhtiari, M.; Jernigan, T.; Wurden, G.

    2006-01-01

    Damaging effects of disruptions are a major concern for Alcator C-Mod, ITER and future tokamak reactors. High-pressure noble gas jet injection is a mitigation technique which potentially satisfies the operational requirements of fast response time and reliability, while still being benign to subsequent discharges. Disruption mitigation experiments using an optimized gas jet injection system are being carried out on Alcator C-Mod to study the physics of gas jet penetration into high pressure plasmas, as well as the ability of the gas jet impurities to convert plasma energy into radiation on timescales consistent with C-Mod's fast quench times, and to reduce halo currents given C-Mod's high-current density. The dependence of impurity penetration and effectiveness on noble gas species (He, Ne, Ar, Kr) is also being studied. It is found that the high-pressure neutral gas jet does not penetrate deeply into the C-Mod plasma, and yet prompt core thermal quenches are observed on all gas jet shots. 3D MHD modelling of the disruption physics with NIMROD shows that edge cooling of the plasma triggers fast growing tearing modes which rapidly produce a stochastic region in the core of the plasma and loss of thermal energy. This may explain the apparent effectiveness of the gas jet in C-Mod despite its limited penetration. The higher-Z gases (Ne, Ar, Kr) also proved effective at reducing halo currents and decreasing thermal deposition to the divertor surfaces. In addition, noble gas jet injection proved to be benign for plasma operation with C-Mod's metal (Mo) wall, actually improving the reliability of the startup in the following discharge

  5. Electron beam disruption simulation of first wall material

    International Nuclear Information System (INIS)

    Quataert, D.; Brossa, F.; Moretto, P.; Rigon, G.

    1984-01-01

    The destructive effect of plasma disruptions on first wall material and limiters has been predicted and models have been made to study their behaviour under intensive pulsed energy deposition. The results presented here give a full description of qualitative and semi-quantitative results obtained for several materials (Mo, stainless steel, Cu, Al, Inconel, etc.) under various experimental conditions. Examples are given of specific defects such as: evaporation, melting, void and crack formation and recrystallization of the underlying material. Methods for the evaluation of deposited energy and beam dimensions are also presented. (author)

  6. Playware ABC 2: a Disruptive Technology for Global Development

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop

    2017-01-01

    The Playware ABC concept is used to create solutions that are usable by all kinds of users and contexts in our globalized society. In this paper, the Playware ABC can be exemplified with the development of the modular interactive tiles for health prevention and rehabilitation of anybody, anywhere......, anytime. The paper gives examples of how playware becomes a disruptive technology for global development, for instance in the health sector. For instance, in Tanzania doctors and community-based rehabilitation workers are constructing and combining modular playware tiles to easily create the right kind...

  7. Disruption management - operations research between planning and execution

    DEFF Research Database (Denmark)

    Clausen, Jens; Larsen, Jesper; Larsen, Allan

    2001-01-01

    For a large number of applications Operations Research has a proven track record: it can deliver high quality solutions for planning problems. Important examples can be found in the airline industry, logistics and production management. This report will describe real-world examples of a novel way...... of applying Operations Research: As plans have to be adjusted to take last minute changes into consideration, OR can play an active role in such a situation by producing, maybe even in a pro-actively role, alternative plans. This type of activity is called Disruption Management....

  8. Accountable Care Units: A Disruptive Innovation in Acute Care Delivery.

    Science.gov (United States)

    Castle, Bryan W; Shapiro, Susan E

    2016-01-01

    Accountable Care Units are a disruptive innovation that has moved care on acute care units from a traditional silo model, in which each discipline works separately from all others, to one in which multiple disciplines work together with patients and their families to move patients safely through their hospital stay. This article describes the "what," "how," and "why" of the Accountable Care Units model as it has evolved in different locations across a single health system and includes the lessons learned as different units and hospitals continue working to implement the model in their complex care environments.

  9. Possible endocrine disrupting effects of parabens and their metabolites

    DEFF Research Database (Denmark)

    Boberg, Julie; Taxvig, Camilla; Christiansen, Sofie

    2010-01-01

    and provides an overview of studies on toxicokinetics. After dermal uptake, parabens are hydrolyzed and conjugated and excreted in urine. Despite high total dermal uptake of paraben and metabolites,little intact paraben can be recovered in blood and urine. Paraben metabolites may play a role in the endocrine...... disruption seen in experimental animals and studies are needed to determine human levels of parabens and metabolites. Overall, the estrogenic burden of parabens and their metabolites in blood may exceed the action of endogenous estradiol in childhood and the safety margin for propylparaben is very low when...

  10. Critical issues and experimental examination on sawtooth and disruption physics

    International Nuclear Information System (INIS)

    Itoh, K.; Itoh, S.; Fukuyama, A.; Tsuji, S.

    1992-06-01

    The catastrophic phenomena which are associated with the major disruption and sawtooth contain three key processes: (1) Sudden acceleration of the growth of the helical deformation, (2) Central electron temperature crash, and (3) Rearrangement of the plasma current. Based on the theoretical model that the magnetic stochasticity plays a key role in these processes, the critical issues and possible experimental tests are proposed. Present experimental observations would be sufficient to study the detailed sequences and causes. Though models may not be complete the comparison with experiments improves understandings. (author)

  11. Case for integral core-disruptive accident analysis

    International Nuclear Information System (INIS)

    Luck, L.B.; Bell, C.R.

    1985-01-01

    Integral analysis is an approach used at the Los Alamos National Laboratory to cope with the broad multiplicity of accident paths and complex phenomena that characterize the transition phase of core-disruptive accident progression in a liquid-metal-cooled fast breeder reactor. The approach is based on the combination of a reference calculation, which is intended to represent a band of similar accident paths, and associated system- and separate-effect studies, which are designed to determine the effect of uncertainties. Results are interpreted in the context of a probabilistic framework. The approach was applied successfully in two studies; illustrations from the Clinch River Breeder Reactor licensing assessment are included

  12. Biofilm disruption with rotating microrods enhances antimicrobial efficacy

    Science.gov (United States)

    Mair, Lamar O.; Nacev, Aleksandar; Hilaman, Ryan; Stepanov, Pavel Y.; Chowdhury, Sagar; Jafari, Sahar; Hausfeld, Jeffrey; Karlsson, Amy J.; Shirtliff, Mark E.; Shapiro, Benjamin; Weinberg, Irving N.

    2017-04-01

    Biofilms are a common and persistent cause of numerous illnesses. Compared to planktonic microbes, biofilm residing cells often demonstrate significant resistance to antimicrobial agents. Thus, methods for dislodging cells from the biofilm may increase the antimicrobial susceptibility of such cells, and serve as a mechanical means of increasing antimicrobial efficacy. Using Aspergillus fumigatus as a model microbe, we magnetically rotate microrods in and around biofilm. We show that such rods can improve the efficacy of antimicrobial Amphotericin B treatments in vitro. This work represents a first step in using kinetic magnetic particle therapy for disrupting fungal biofilms.

  13. Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

    DEFF Research Database (Denmark)

    Hartoft-Nielsen, Marie-Louise; Boas, Malene; Bliddal, Sofie

    2011-01-01

    constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal...... neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use...

  14. Endocrine disrupting compounds exposure and testis development in mammals

    Science.gov (United States)

    Egbowona, Biola F.; Mustapha, Olajide A.

    2011-01-01

    In the last few decades, there is substantial evidence that male reproductive function is deteriorating in humans and wildlife and this is associated with unintentional exposure to widely used synthetic chemicals. Subsequently, much has been done to show that certain chemicals in the environment adversely interfere with the developing fetal gonads of the laboratory animals. Some in vitro studies have demonstrated treatment-induced reproductive problems in offspring exposed to endocrine disrupting compounds (EDC) which are similar to those observed in wildlife and human population. Few EDC studies have demonstrated that there are certain periods of gestation when the developing fetus is highly sensitive and at risk of small endocrine changes. Similar observations have been made in the sewage sludge model, however, while animal studies have been insightful in providing valuable information about the range of effects that can be attributed to in utero exposure to EDCs, varying levels of maternal doses administered in different studies exaggerated extrapolation of these results to human. Thus the EDC concentration representative of fetal exposure levels is uncertain because of the complexities of its nature. So far, the level of fetal exposure can only be roughly estimated. There is substantial evidence from animal data to prove that EDCs can adversely affect reproductive development and function in male and more has accumulated on the mechanisms by which they exert their effects. This paper therefore, reviews previous studies to highlight the extent to which testis development can be disrupted during fetal life. PMID:29255381

  15. The deep learning AI playbook strategy for disruptive artificial intelligence

    CERN Document Server

    Perez, Carlos E

    2017-01-01

    Deep Learning Artificial Intelligence involves the interplay of Computer Science, Physics, Biology, Linguistics and Psychology. In addition to that, it is technology that can be extremely disruptive. The ramifications to society and even our own humanity will be profound. There are few subjects that are as captivating and as consequential as this. Surprisingly, there is very little that is written about this new technology in a more comprehensive and cohesive way. This book is an opinionated take on the developments of Deep Learning AI. One question many have will be "how to apply Deep Learning AI in a business context?" Technology that is disruptive does not automatically imply that its application to valuable use cases will be apparent. For years, many people could not figure out how to monetize the World Wide Web. We are in a similar situation with Deep Learning AI. The developments may be mind-boggling but its monetization is far from being obvious. This book presents a framework to address this shortcomi...

  16. Disrupted seasonal biology impacts health, food security and ecosystems

    Science.gov (United States)

    Stevenson, T. J.; Visser, M. E.; Arnold, W.; Barrett, P.; Biello, S.; Dawson, A.; Denlinger, D. L.; Dominoni, D.; Ebling, F. J.; Elton, S.; Evans, N.; Ferguson, H. M.; Foster, R. G.; Hau, M.; Haydon, D. T.; Hazlerigg, D. G.; Heideman, P.; Hopcraft, J. G. C.; Jonsson, N. N.; Kronfeld-Schor, N.; Kumar, V.; Lincoln, G. A.; MacLeod, R.; Martin, S. A. M.; Martinez-Bakker, M.; Nelson, R. J.; Reed, T.; Robinson, J. E.; Rock, D.; Schwartz, W. J.; Steffan-Dewenter, I.; Tauber, E.; Thackeray, S. J.; Umstatter, C.; Yoshimura, T.; Helm, B.

    2015-01-01

    The rhythm of life on earth is shaped by seasonal changes in the environment. Plants and animals show profound annual cycles in physiology, health, morphology, behaviour and demography in response to environmental cues. Seasonal biology impacts ecosystems and agriculture, with consequences for humans and biodiversity. Human populations show robust annual rhythms in health and well-being, and the birth month can have lasting effects that persist throughout life. This review emphasizes the need for a better understanding of seasonal biology against the backdrop of its rapidly progressing disruption through climate change, human lifestyles and other anthropogenic impact. Climate change is modifying annual rhythms to which numerous organisms have adapted, with potential consequences for industries relating to health, ecosystems and food security. Disconcertingly, human lifestyles under artificial conditions of eternal summer provide the most extreme example for disconnect from natural seasons, making humans vulnerable to increased morbidity and mortality. In this review, we introduce scenarios of seasonal disruption, highlight key aspects of seasonal biology and summarize from biomedical, anthropological, veterinary, agricultural and environmental perspectives the recent evidence for seasonal desynchronization between environmental factors and internal rhythms. Because annual rhythms are pervasive across biological systems, they provide a common framework for trans-disciplinary research. PMID:26468242

  17. Local and integral disruption forces on the tokamak wall

    Science.gov (United States)

    Pustovitov, V. D.; Kiramov, D. I.

    2018-04-01

    The disruption-induced forces on the tokamak wall are evaluated analytically within the standard large-aspect-ratio model that implies axisymmetry, circular plasma and wall, and absence of halo currents. Additionally, the ideal-wall reaction is assumed. The disruptions are modelled as rapid changes in the plasma pressure (thermal quench (TQ)) and net current (current quench (CQ)). The force distribution over the poloidal angle is found as a function of these inputs. The derived formulas allow comparison of the TQ- and CQ-produced forces calculated differently, with and without account of the poloidal current induced in the wall. The latter variant represents the inherent property of the codes treating the wall as a set of toroidal filaments. It is proved here that such a simplification leads to unacceptably large errors in the simulated forces for both TQs and CQs. It is also shown that the TQ part of the force must prevail over that due to CQ in the high-β scenarios developed for JT-60SA and ITER.

  18. Peer deviance, parenting and disruptive behavior among young girls.

    Science.gov (United States)

    Miller, Shari; Loeber, Rolf; Hipwell, Alison

    2009-02-01

    This study examined concurrent and longitudinal associations between peer deviance, parenting practices, and conduct and oppositional problems among young girls ages 7 and 8. Participants were 588 African American and European American girls who were part of a population-based study of the development of conduct problems and delinquency among girls. Affiliations with problem-prone peers were apparent among a sizeable minority of the girls, and these associations included both males and females. Although peer delinquency concurrently predicted disruptive behaviors, the gender of these peers did not contribute to girls' behavior problems. Harsh parenting and low parental warmth showed both concurrent and prospective associations with girls' disruptive behaviors. Similar patterns of association were seen for African American and European American girls. The findings show that peer and parent risk processes are important contributors to the early development of young girls' conduct and oppositional behaviors. These data contribute to our understanding of girls' aggression and antisocial behaviors and further inform our understanding of risk processes for these behaviors among young girls in particular.

  19. Amphipathic beta-strand mimics as potential membrane disruptive antibiotics.

    Science.gov (United States)

    Watson, Jessica L; Gillies, Elizabeth R

    2009-08-21

    In recent years, there have been increasing numbers of bacterial strains emerging that are resistant to the currently available antibiotics. In the search for new antibiotics, attention has been focused on natural antimicrobial peptides that act by selectively disrupting the membranes of bacterial cells, a mechanism that is thought to be nonconducive to the development of resistance. It is desirable to mimic the structures and activities of these peptides while introducing properties such as resistance to proteolytic degradation, which make molecules more ideal for development as drugs. Described here is the design and synthesis of beta-strand mimetic oligomers based on alternating alpha-amino acids and azacyclohexenone units that segregate cationic lysine and hydrophobic valine side chains on opposite faces of the beta-strand. (1)H NMR dilution studies demonstrated that despite the incorporation of alternating d- and l-amino acids in order to obtain facial amphiphilicity, these oligomers are capable of dimerizing to beta-sheet mimics in a manner similar to the oligomers containing all l-amino acids. The ability of the molecules to disrupt phospholipid vesicles mimicking the membranes of both bacterial and mammalian cells was investigated using a fluorescent dye leakage assay. Several of the oligomers were found to exhibit activity and selectivity for the bacterial over mammalian membranes. Overall, these studies demonstrate the promise of this class of molecules for the development of new potential antibiotics and provide information on the structural features that are important for activity.

  20. Enhanced collective influence: A paradigm to optimize network disruption

    Science.gov (United States)

    Wu, Tao; Chen, Leiting; Zhong, Linfeng; Xian, Xingping

    2017-04-01

    The function of complex networks typically relies on the integrity of underlying structure. Sometimes, practical applications need to attack networks' function, namely inactivate and fragment networks' underlying structure. To effectively dismantle complex networks and regulate the function of them, a centrality measure, named CI (Morone and Makse, 2015), was proposed for node ranking. We observe that the performance of CI centrality in network disruption problem may deteriorate when it is used in networks with different topology properties. Specifically, the structural features of local network topology are overlooked in CI centrality, even though the local network topology of the nodes with a fixed CI value may have very different organization. To improve the ranking accuracy of CI, this paper proposes a variant ECI to CI by considering loop density and degree diversity of local network topology. And the proposed ECI centrality would degenerate into CI centrality with the reduction of the loop density and the degree diversity level. By comparing ECI with CI and classical centrality measures in both synthetic and real networks, the experimental results suggest that ECI can largely improve the performance of CI for network disruption. Based on the results, we analyze the correlation between the improvement and the properties of the networks. We find that the performance of ECI is positively correlated with assortative coefficient and community modularity and negatively correlated with degree inequality of networks, which can be used as guidance for practical applications.

  1. Bisphenol A, an endocrine-disrupting chemical, and brain development.

    Science.gov (United States)

    Itoh, Kyoko; Yaoi, Takeshi; Fushiki, Shinji

    2012-08-01

    Bisphenol A (BPA) is an endocrine-disrupting chemical, widely used in various industries and the field of dentistry. The consequent increase in BPA exposure among humans has led us to some concerns regarding the potential deleterious effects on reproduction and brain development. The emphasis of this review is on the effects of prenatal and lactational exposure to low doses of BPA on brain development in mice. We demonstrated that prenatal exposure to BPA affected fetal murine neocortical development by accelerating neuronal differentiation/migration during the early embryonic stage, which was associated with up- and down-regulation of the genes critical for brain development, including the basic helix-loop-helix transcription factors. In the adult mice brains, both abnormal neocortical architecture and abnormal corticothalamic projections persisted in the group exposed to the BPA. Functionally, BPA exposure disturbed murine behavior, accompanied with a disrupted neurotransmitter system, including monoamines, in the postnatal development period and in adult mice. We also demonstrated that epigenetic alterations in promoter-associated CpG islands might underlie some of the effects on brain development after exposure to BPA. © 2012 Japanese Society of Neuropathology.

  2. Divided attention disrupts perceptual encoding during speech recognition.

    Science.gov (United States)

    Mattys, Sven L; Palmer, Shekeila D

    2015-03-01

    Performing a secondary task while listening to speech has a detrimental effect on speech processing, but the locus of the disruption within the speech system is poorly understood. Recent research has shown that cognitive load imposed by a concurrent visual task increases dependency on lexical knowledge during speech processing, but it does not affect lexical activation per se. This suggests that "lexical drift" under cognitive load occurs either as a post-lexical bias at the decisional level or as a secondary consequence of reduced perceptual sensitivity. This study aimed to adjudicate between these alternatives using a forced-choice task that required listeners to identify noise-degraded spoken words with or without the addition of a concurrent visual task. Adding cognitive load increased the likelihood that listeners would select a word acoustically similar to the target even though its frequency was lower than that of the target. Thus, there was no evidence that cognitive load led to a high-frequency response bias. Rather, cognitive load seems to disrupt sublexical encoding, possibly by impairing perceptual acuity at the auditory periphery.

  3. Intracranial radiosurgery: an effective and disruptive innovation in neurosurgery.

    Science.gov (United States)

    Niranjan, Ajay; Madhavan, Ravindranath; Gerszten, Peter C; Lunsford, L Dade

    2012-01-01

    Physicians are guided by the teachings of their chosen field, standards of accepted practice, peer pressure, prior training, and other sources of bias. When potential bias begins to impact recommendations for care in the field of tumor management, physicians may fail to realize the importance of emerging medical innovations. Some of these ultimately turn out to be 'disruptive innovations.' These innovations are more often than not both low risk and cost effective. But the leaders in the field often initially ignore these newer technologies in favor of more mature existing technologies. However, over time these technologies gradually improve and become mainstream management practices. Intracranial radiosurgery is one such innovation which was not embraced by the neurosurgical community in the beginning. Nowadays, a wide variety of brain and body disorders are treated with radiosurgery. Acoustic neuromas and brain metastases are examples of rapidly growing indications of radiosurgery. In this report, the authors describe the emergence of stereotactic radiosurgery as a disruptive innovation in the field of medicine. Copyright © 2011 S. Karger AG, Basel.

  4. Symptom and Surface: Disruptive Deafness and Medieval Medical Authority.

    Science.gov (United States)

    Hsy, Jonathan

    2016-12-01

    This essay examines constructions of deafness in medieval culture, exploring how deaf experience disrupts authoritative discourses in three textual genres: medical treatise, literary fiction, and autobiographical writing. Medical manuals often present deafness as a physical defect, yet they also suggest how social conditions for deaf people can be transformed in lieu of treatment protocols. Fictional narratives tend to associate deafness with sin or social stigma, but they can also imagine deaf experience with a remarkable degree of sympathy and nuance. Autobiographical writing by deaf authors most vividly challenges diagnostic models of disability, exploring generative forms of perception that deafness can foster. In tracing the disruptive force that deaf experience exerts on perceived notions of textual authority, this essay reveals how medieval culture critiqued the diagnostic power of medical practitioners. Deafness does not simply function as a symptom of an individual problem or a metaphor for a spiritual or social condition; rather, deafness is a transformative capacity affording new modes of knowing self and other.

  5. Tidal disruption of asteroids by supermassive black holes

    Directory of Open Access Journals (Sweden)

    Gomboc A.

    2012-12-01

    Full Text Available The compact radio source Sgr A* at the centre of our Galaxy harbours a super-massive black hole, and is therefore the nearest laboratory for testing the super-massive black hole astrophysics and environment. Since it is not an active galactic nucleus, it also offers the possibility of observing the capture of low-mass objects, such as comets or asteroids, that may orbit the central black hole. In this paper we discuss conditions for tidal disruption of low-mass objects and predictions of the appearance and light curve of such events, as well as their relevance for the X-ray and infra-red flares detected in Sgr A*. The modelled light curves of such tidal disruption events bear marks of the strong gravitational field: tidal squeezing and elongation of the object, gravitational lensing, aberration of light, and Doppler effects. Finally, we show that this model is able to reproduce and fit X-ray flares.

  6. Functional Analytic Psychotherapy among Mothers with Children with Disruptive Behavior

    Directory of Open Access Journals (Sweden)

    Johanna Romero-Porras

    2018-02-01

    Full Text Available Children’s mental problems remain one of the central topics in governments’ agendas because of their negative impact at social and economic levels. The present paper is a single case study, with A-B design with concurrent control through behaviors and participants, aimed to identify the effect of the Functional Analytic Psychotherapy (FAP on four mothers who informed about their children’s disruptive behaviors in the school setting. A case-control who received psychoeducation-based intervention was included in order to observe outcome differences among participants regarding the implemented treatment. Using the FIAT-Q and functional analysis, participants’ problematic behaviors were identified. Mothers treated with FAP were expected to display behavioral changes within the sessions and generalized them to the natural context in the interaction with their children in order to promote children’s prosocial behaviors. Results indicated that FAP reduced the frequency of mothers’ problematic behaviors and, in turn, children reduced disruptive behaviors. Implications of the study results are discussed both at theoretical and applied levels.

  7. Ionizing radiation induces heritable disruption of epithelial cell interactions

    Science.gov (United States)

    Park, Catherine C.; Henshall-Powell, Rhonda L.; Erickson, Anna C.; Talhouk, Rabih; Parvin, Bahram; Bissell, Mina J.; Barcellos-Hoff, Mary Helen; Chatterjee, A. (Principal Investigator)

    2003-01-01

    Ionizing radiation (IR) is a known human breast carcinogen. Although the mutagenic capacity of IR is widely acknowledged as the basis for its action as a carcinogen, we and others have shown that IR can also induce growth factors and extracellular matrix remodeling. As a consequence, we have proposed that an additional factor contributing to IR carcinogenesis is the potential disruption of critical constraints that are imposed by normal cell interactions. To test this hypothesis, we asked whether IR affected the ability of nonmalignant human mammary epithelial cells (HMEC) to undergo tissue-specific morphogenesis in culture by using confocal microscopy and imaging bioinformatics. We found that irradiated single HMEC gave rise to colonies exhibiting decreased localization of E-cadherin, beta-catenin, and connexin-43, proteins necessary for the establishment of polarity and communication. Severely compromised acinar organization was manifested by the majority of irradiated HMEC progeny as quantified by image analysis. Disrupted cell-cell communication, aberrant cell-extracellular matrix interactions, and loss of tissue-specific architecture observed in the daughters of irradiated HMEC are characteristic of neoplastic progression. These data point to a heritable, nonmutational mechanism whereby IR compromises cell polarity and multicellular organization.

  8. Steeper Stellar Cusps in Galactic Centers from Binary Disruption

    Science.gov (United States)

    Fragione, Giacomo; Sari, Re’em

    2018-01-01

    The relaxed distribution of stars around a massive black hole is known to follow a cusp profile, ρ (r)\\propto {r}-α , with a characteristic slope α =7/4. This follows from energy conservation and a scattering rate given by two-body encounters. However, we show that the injection of stars close to the black hole, i.e., a source term in the standard cusp picture, modifies this profile. In the steady-state configuration, the cusp develops a central region with a typical slope α =9/4 in which stars diffuse outward. Binary disruption by the intense tidal field of the massive black hole is among the phenomena that take place in the Galactic Center (GC). In such a disruption, one of the binary members remains bound to the black hole, thus providing a source term of stars close to the black hole. Assuming a binary fraction of 0.1 and an orbital circularization efficiency of 0.35, we show that this source is strong enough to modify the cusp profile within ≈ 0.07 pc of the GC. If the binary fraction at the influence radius is of order unity and the orbits of all captured stars are efficiently circularized, the steeper cusp extends almost as far as the radius of influence of the black hole.

  9. Disruption of magnetospheric current sheet by quasi-electrostatic field

    Directory of Open Access Journals (Sweden)

    W. W. Liu

    2009-05-01

    Full Text Available Recent observational evidence has indicated that local current sheet disruptions are excited by an external perturbation likely associated with the kinetic ballooning (KB instability initiating at the transition region separating the dipole- and tail-like geometries. Specifically a quasi-electrostatic field pointing to the neutral sheet was identified in the interval between the arrival of KB perturbation and local current disruption. How can such a field drive the local current sheet unstable? This question is considered through a fluid treatment of thin current sheet (TCS where the generalized Ohm's law replaces the frozen-in-flux condition. A perturbation with the wavevector along the current is applied, and eigenmodes with frequency much below the ion gyrofrequency are sought. We show that the second-order derivative of ion drift velocity along the thickness of the current sheet is a critical stability parameter. In an E-field-free Harris sheet in which the drift velocity is constant, the current sheet is stable against this particular mode. As the electrostatic field grows, however, potential for instability arises. The threshold of instability is identified through an approximate analysis of the theory. For a nominal current sheet half-thickness of 1000 km, the estimated instability threshold is E~4 mV/m. Numerical solutions indicate that the two-fluid theory gives growth rate and wave period consistent with observations.

  10. Intracellular renin disrupts chemical communication between heart cells. Pathophysiological implications

    Directory of Open Access Journals (Sweden)

    Walmor eDe Mello

    2015-01-01

    Full Text Available The influence of intracellular renin on the process of chemical communication between cardiac cells was investigated in cell pairs isolated from the left ventricle of adult Wistar Kyoto rats. The enzyme together with Lucifer yellow CH was dialyzed into one cell of the pair using the whole cell clamp technique. The diffusion of the dye in the dialyzed and in non-dialyzed cell was followed by measuring the intensity of fluorescence in both cells as a function of time. The results indicated that; 1 under normal conditions, Lucifer Yellow flows from cell-to-cell through gap junctions; 2 the intracellular dialysis of renin (100nM disrupts chemical communication-an effect enhanced by simultaneous administration of angiotensinogen (100nM; 3 enalaprilat (10-9M administered to the cytosol together with renin reduced drastically the uncoupling action of the enzyme; 4 aliskiren (10-8M inhibited the effect of renin on chemical communication;5 the possible role of intracellular renin independently of angiotensin II (Ang II was evaluated including the increase of the inward calcium current elicited by the enzyme and the possible role of oxidative stress on the disruption of cell communication; 6 the possible harmful versus the beneficial effect of intracellular renin during myocardial infarction was discussed;7 the present results indicate that intracellular renin due to internalization or in situ synthesis, causes a severe impairment of chemical communication in the heart resulting in derangement of metabolic cooperation with serious consequences for heart function.

  11. Runaway beam studies during disruptions at JET-ILW

    International Nuclear Information System (INIS)

    Reux, C.; Plyusnin, V.; Alper, B.; Alves, D.; Bazylev, B.; Belonohy, E.; Brezinsek, S.; Decker, J.; Devaux, S.; Vries, P. de; Fil, A.

    2015-01-01

    Highlights: • Runaway electrons (RE) have been obtained at JET-ILW using massive argon injection. • The runaway electron domain entry points are similar between JET-C and JET-ILW. • Inside the runaway electron domain, higher RE currents are observed with JET-ILW. • RE impact has been observed without material melting up to 100 kA RE current. • Heat deposition of 2 ± 1 mm is confirmed by measurements and simulations. - Abstract: Runaway electrons (RE) during disruptions are a concern for future tokamaks including ITER with its metallic wall. Although RE are rare in spontaneous disruptions with the JET ITER-like Wall (JET-ILW), RE beams up to 380 kA were obtained using massive injection (MGI) of argon in JET-ILW divertor discharges. Entry points into the RE domain defined by operational parameters (toroidal field, argon fraction in MGI) are unchanged but higher RE currents have been obtained inside the JET-ILW MGI-generated RE domain when compared to JET-C. This might be due to the influence of the metallic wall on the current quench plasma. Temperatures of 900 °C have been observed following RE impacts on beryllium tiles. Heat deposition depth of ∼2 mm has to be assumed to match the tile cooling time. 3D simulations of the RE energy deposition using the ENDEP/MEMOS codes show that material melting is unlikely with 100 kA RE beams

  12. Runaway beam studies during disruptions at JET-ILW

    Energy Technology Data Exchange (ETDEWEB)

    Reux, C., E-mail: cedric.reux@cea.fr [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Plyusnin, V. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Instituto de Plasmas e Fuso Nuclear, Instituto Superior Tcnico, Universidade de Lisboa, Lisboa (Portugal); Alper, B. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Alves, D. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Instituto de Plasmas e Fuso Nuclear, Instituto Superior Tcnico, Universidade de Lisboa, Lisboa (Portugal); Bazylev, B. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Institut für Hochleistungsimpuls und Mikrowellentechnik, Karlsruhe Institute of Technology, Campus Nord, 76021 Karlsruhe (Germany); Belonohy, E. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); EFDA-CSU, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Brezinsek, S. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Forschungszentrum Jülich GmbH, Institut für Energie-und Klimaforschung-Plasmaphysik, 52425 Jülich (Germany); Decker, J. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Devaux, S. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CCFE, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); Vries, P. de [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); ITER Organization, Route de Vinon sur Verdon, 13115 St Paul Lez Durance (France); Fil, A. [JET-EFDA, Culham Science Centre, Abingdon OX14 3DB (United Kingdom); CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); and others

    2015-08-15

    Highlights: • Runaway electrons (RE) have been obtained at JET-ILW using massive argon injection. • The runaway electron domain entry points are similar between JET-C and JET-ILW. • Inside the runaway electron domain, higher RE currents are observed with JET-ILW. • RE impact has been observed without material melting up to 100 kA RE current. • Heat deposition of 2 ± 1 mm is confirmed by measurements and simulations. - Abstract: Runaway electrons (RE) during disruptions are a concern for future tokamaks including ITER with its metallic wall. Although RE are rare in spontaneous disruptions with the JET ITER-like Wall (JET-ILW), RE beams up to 380 kA were obtained using massive injection (MGI) of argon in JET-ILW divertor discharges. Entry points into the RE domain defined by operational parameters (toroidal field, argon fraction in MGI) are unchanged but higher RE currents have been obtained inside the JET-ILW MGI-generated RE domain when compared to JET-C. This might be due to the influence of the metallic wall on the current quench plasma. Temperatures of 900 °C have been observed following RE impacts on beryllium tiles. Heat deposition depth of ∼2 mm has to be assumed to match the tile cooling time. 3D simulations of the RE energy deposition using the ENDEP/MEMOS codes show that material melting is unlikely with 100 kA RE beams.

  13. The Disruption of Tephra Fall Deposits by Basaltic Lava Flows

    Science.gov (United States)

    Brown, R. J.; Thordarson, T.; Self, S.; Blake, S.

    2010-12-01

    Complex physical and stratigraphic relationships between lava and proximal tephra fall deposits around vents of the Roza Member in the Columbia River Basalt Province, (CRBP), USA, illustrate how basaltic lavas can disrupt, dissect (spatially and temporally) and alter tephra fall deposits. Thin pahoehoe lobes and sheet lobes occur intercalated with tephra deposits and provide evidence for synchronous effusive and explosive activity. Tephra that accumulated on the tops of inflating pahoehoe flows became disrupted by tumuli, which dissected the overlying sheet into a series of mounds. During inflation of subjacent tumuli tephra percolated down into the clefts and rubble at the top of the lava, and in some cases came into contact with lava hot enough to thermally alter it. Lava breakouts from the tumuli intruded up through the overlying tephra deposit and fed pahoehoe flows that spread across the surface of the aggrading tephra fall deposit. Non-welded scoria fall deposits were compacted and welded to a depth of ~50 cm underneath thick sheet lobes. These processes, deduced from the field relationships, have resulted in considerable stratigraphic complexity in proximal regions. We also demonstrate that, when the advance of lava and the fallout of tephra are synchronous, the contacts of some tephra sheets can be diachronous across their extent. The net effect is to reduce the usefulness of pyroclastic deposits in reconstructing eruption dynamics.

  14. Catastrophic disruptions as the origin of bilobate comets

    Science.gov (United States)

    Schwartz, Stephen R.; Michel, Patrick; Jutzi, Martin; Marchi, Simone; Zhang, Yun; Richardson, Derek C.

    2018-03-01

    Several comets observed at close range have bilobate shapes1, including comet 67P/Churyumov-Gerasimenko (67P/C-G), which was imaged by the European Space Agency's Rosetta mission2,3. Bilobate comets are thought to be primordial because they are rich in supervolatiles (for example, N2 and CO) and have a low bulk density, which implies that their formation requires a very low-speed accretion of two bodies. However, slow accretion does not only occur during the primordial phase of the Solar System; it can also occur at later epochs as part of the reaccumulation process resulting from the collisional disruption of a larger body4, so this cannot directly constrain the age of bilobate comets. Here, we show by numerical simulation that 67P/C-G and other elongated or bilobate comets can be formed in the wake of catastrophic collisional disruptions of larger bodies while maintaining their volatiles and low density throughout the process. Since this process can occur at any epoch of our Solar System's history, from early on through to the present day5, there is no need for these objects to be formed primordially. These findings indicate that observed prominent geological features, such as pits and stratified surface layers4,5, may not be primordial.

  15. Light pollution disrupts sleep in free-living animals.

    Science.gov (United States)

    Raap, Thomas; Pinxten, Rianne; Eens, Marcel

    2015-09-04

    Artificial lighting can alter individual behaviour, with often drastic and potentially negative effects on biological rhythms, daily activity and reproduction. Whether this is caused by a disruption of sleep, an important widespread behaviour enabling animals to recover from daily stress, is unclear. We tested the hypothesis that light pollution disrupts sleep by recording individual sleep behaviour of great tits, Parus major, that were roosting in dark nest-boxes and were exposed to light-emitting diode light the following night. Their behaviour was compared to that of control birds sleeping in dark nest-boxes on both nights. Artificial lighting caused experimental birds to wake up earlier, sleep less (-5%) and spent less time in the nest-box as they left their nest-box earlier in the morning. Experimental birds did not enter the nest-box or fall asleep later than controls. Although individuals in lit nest-boxes did not wake up more often nor decreased the length of their sleep bouts, females spent a greater proportion of the night awake. Our study provides the first direct proof that light pollution has a significant impact on sleep in free-living animals, in particular in the morning, and highlights a mechanism for potential effects of light pollution on fitness.

  16. Impact of Disruptive Innovations on Mobile Telecom Industry in Lebanon

    Directory of Open Access Journals (Sweden)

    Wael Bakhit

    2016-04-01

    Full Text Available The telecommunication industry is different from other industries in the basis of innovation rate. This industry continuously provides end users with new technological generations and disruptive technologies. Due to the complexity of the nature of the product served, telecommunication industry is an important case to study in order to explain the real reasons for the challenges facing telecom companies. Researching in this area will explain why some companies survive while others fail. The wide range served technology innovations is most likely to result in rapid mutation of consumers’ spending habits thus directly influencing the mobile phone companies. The aim of this is to test the reliability of innovations and its impact on companies’ profitability. For that purpose, a survey with 200 end users and 20 employees from two telecom providers (“Alfa, and “Touch” was conducted to investigate various disruptive and conventional means and their impact on the financial performance of telecom industry. The results show that most of the revenue of telecom industry comes from usage of data while the industry is lacking for competition, and quality services while charging high tariffs for customers. Currently customers are migrating to data, therefore performing a pressure on the industry to improve its services. To conclude, network operators need to decide what to they want to sacrifice and how far they want to go to reach targeted results.

  17. Gaia DR1 Evidence of Disrupting the Perseus Arm

    Science.gov (United States)

    Baba, Junichi; Kawata, Daisuke; Matsunaga, Noriyuki; Grand, Robert J. J.; Hunt, Jason A. S.

    2018-02-01

    We have discovered a clear sign of the disruption phase of the Perseus arm in the Milky Way using Cepheid variables, taking advantage of the accurately measured distances of Cepheids and the proper motions from Gaia Data Release 1. Both the Galactocentric radial and rotation velocities of 77 Cepheids within 1.5 kpc of the Perseus arm are correlated with their distances from the locus of the Perseus arm, as the trailing side is rotating faster and moving inward compared to the leading side. We also found a negative vertex deviation for the Cepheids on the trailing side, ‑27.°6 ± 2.°4, in contrast to the positive vertex deviation in the solar neighborhood. This is, to our knowledge, the first direct evidence that the vertex deviation around the Perseus arm is affected by the spiral arm. We compared these observational trends with our N-body/hydrodynamics simulations based on a static density-wave spiral scenario and with those based on a transient dynamic spiral scenario. Although our comparisons are limited to qualitative trends, they strongly favor the conclusion that the Perseus arm is in the disruption phase of a transient arm.

  18. Biomarkers for circadian rhythm disruption independent of time of day.

    Directory of Open Access Journals (Sweden)

    Kirsten C G Van Dycke

    Full Text Available Frequent shift work causes disruption of the circadian rhythm and might on the long-term result in increased health risk. Current biomarkers evaluating the presence of circadian rhythm disturbance (CRD, including melatonin, cortisol and body temperature, require 24-hr ("around the clock" measurements, which is tedious. Therefore, these markers are not eligible to be used in large-scale (human studies. The aim of the present study was to identify universal biomarkers for CRD independent of time of day using a transcriptomics approach. Female FVB mice were exposed to six shifts in a clockwise (CW and counterclockwise (CCW CRD protocol and sacrificed at baseline and after 1 shift, 6 shifts, 5 days recovery and 14 days recovery, respectively. At six time-points during the day, livers were collected for mRNA microarray analysis. Using a classification approach, we identified a set of biomarkers able to classify samples into either CRD or non-disrupted based on the hepatic gene expression. Furthermore, we identified differentially expressed genes 14 days after the last shift compared to baseline for both CRD protocols. Non-circadian genes differentially expressed upon both CW and CCW protocol were considered useful, universal markers for CRD. One candidate marker i.e. CD36 was evaluated in serum samples of the CRD animals versus controls. These biomarkers might be useful to measure CRD and can be used later on for monitoring the effectiveness of intervention strategies aiming to prevent or minimize chronic adverse health effects.

  19. ITER vacuum vessel dynamic stress analysis of a disruption

    International Nuclear Information System (INIS)

    Riemer, B.W.; Conner, D.L.; Strickler, D.J.; Williamson, D.E.

    1994-01-01

    Dynamic stress analysis of the International Thermonuclear Experimental Reactor vacuum vessel loaded by disruption forces was performed. The deformation and stress results showed strong inertial effects when compared to static analyses. Maximum stress predicted dynamically was 300 MPa, but stress shown by static analysis from loads at the same point in time reached only 80 MPa. The analysis also provided a reaction load history in the vessel's supports which is essential in evaluating support design. The disruption forces were estimated by assuming a 25-MA plasma current decaying at 1 MA/ms while moving vertically. In addition to forces developed within the vessel, vertical loadings from the first wall/strong back assemblies and the divertor were applied to the vessel at their attachment points. The first 50 natural modes were also determined. The first mode's frequency was 6.0 Hz, and its shape is characterized by vertical displacement of the vessel inner leg. The predicted deformation of the vessel appeared similar to its first mode shape combined with radial contraction. Kinetic energy history from the analysis also correlated with the first mode frequency

  20. Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.

    Directory of Open Access Journals (Sweden)

    Dae-Hee Lee

    Full Text Available The majority of chordomas show activation of the platelet-derived growth factor receptor (PDGFR. Based on in vitro intertumoral variation in response to recombinant PDGF protein and PDGFR inhibition, and variable tumor response to imatinib, we hypothesized that chordomas resistant to PDGFR inhibition may possess downstream activation of the pathway.Molecular profiling was performed on 23 consecutive chordoma primary tissue specimens. Primary cultures established from 20 of the 23 specimens, and chordoma cell lines, UCH-1 and UCH-2, were used for in vitro experiments.Loss of heterozygosity (LOH at the phosphatase and tensin homolog (PTEN locus was observed in 6 specimens (26%. PTEN disruption statistically correlated with increased Ki-67 proliferation index, an established marker of poor outcome for chordoma. Compared to wild type, PTEN deficient chordomas displayed increased proliferative rate, and responded less favorably to PDGFR inhibition. PTEN gene restoration abrogated this growth advantage. Chordomas are characterized by intratumoral hypoxia and local invasion, and histone deacetylase (HDAC inhibitors are capable of attenuating both hypoxic signaling and cell migration. The combination of PDGFR and HDAC inhibition effectively disrupted growth and invasion of PTEN deficient chordoma cells.Loss of heterozygosity of the PTEN gene seen in a subset of chordomas is associated with aggressive in vitro behavior and strongly correlates with increased Ki-67 proliferative index. Combined inhibition of PDGFR and HDAC attenuates proliferation and invasion in chordoma cells deficient for PTEN.