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Sample records for e3 transition strength

  1. Two- to one-phonon E3 transition strength in {sup 148}Gd

    Energy Technology Data Exchange (ETDEWEB)

    Piiparinen, M [Niels Bohr Institute, Tandem Accelerator Laboratory, Roskilde (Denmark); [Jyvaeskylae Univ. (Finland). Dept. of Physics; Atac, A; Nyberg, J; Ramsoy, T; Sletten, G [Niels Bohr Institute, Tandem Acceleratory Laboratory, Roskile, (Denmark); Virtanen, A; Muller, D [Jyvaeskylae Univ. (Finland). Dept. of Physics; Kleinheinz, P [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Kernphysik; Blomqvist, J [Manne Siegbahn Inst. of Physics, Stockholm (Sweden)

    1992-08-01

    In a plunger experiment the mean life of the ({nu} f{sub 6}{sup 2}x3{sup -}x3{sup -})12{sup +} state at 3.981 MeV in {sub 64}{sup 148}Gd{sub 84} was measured as {tau}=83(10)ps, giving 77(11)B{sub w} for the 1286 keV 12{sup +} {yields} 9{sup -} E3 transition rate, which confirms the double-octupole character of the 12{sup +} state. The observed deviations in energy and transition rate from harmonic vibration are shown to be caused by the exclusion principle acting between nucleons in the two phonons and are related to the dominant contributions to the {sup 148}Gd octupole phonon of the low-lying {Delta}l={Delta}j=3 proton- and neutron in-shell 3{sup -} excitations which are of vital significance for the octupole mode in open-shell nuclei. (author). 17 refs., 2 figs.

  2. E3-transitions in sup(105, 107, 109, 111)Ag

    International Nuclear Information System (INIS)

    Shevelev, G.A.; Troitskaya, A.G.; Kartashov, V.M.

    1978-01-01

    Electron radiation of the isomeric transitions of the sup(105-111)Ag odd nuclei was studied using an iron magnetic πsup(√2) beta spectrometer. For most isomeric transitions, relative intensities of the K, L, M, and N lines have been measured; for sup(105-111)Ag and 111 Cd they were measured for the first time. Energy of gamma transitions, relative intensities of internal conversion electrons (ICE) compared with the theoretical ICE values for the E3 transitions are presented. The observations for all the shells are in a fairly gool agreement with the calculations. Systematics of low-lying excited states of the silver nuclei involved is proposed. It has been established that spins and parities of the first excited states of the sup(105-111)Ag odd nuclei are 7/2 + . Multipolarities of isomeric transitions from these staes are pure E3. Spin and parity 9/2 + of the second excited states may be uniquely determined unly for 109 Ag from direct measurements of the ICE transition at 45.8 keV

  3. Polynomial expansions and transition strengths

    International Nuclear Information System (INIS)

    Draayer, J.P.

    1980-01-01

    The subject is statistical spectroscopy applied to determining strengths and strength sums of excitation processes in nuclei. The focus will be on a ds-shell isoscalar E2 study with detailed shell-model results providing the standard for comparison; similar results are available for isovector E2 and M1 and E4 transitions as well as for single-particle transfer and ν +- decay. The present study is intended to serve as a tutorial for applications where shell-model calculations are not feasible. The problem is posed and a schematic theory for strengths and sums is presented. The theory is extended to include the effect of correlations between H, the system Hamiltonian, and theta, the excitation operator. Associated with correlation measures is a geometry that can be used to anticipate the goodness of a symmetry. This is illustrated for pseudo SU(3) in the fp-shell. Some conclusions about fluctuations and collectivity that one can deduce from the statistical results for strengths are presented

  4. Magnetic moments, E3 transitions and the structure of high spin core excited states in 211Rn

    International Nuclear Information System (INIS)

    Poletti, A.R.; Dracoulis, G.D.; Byrne, A.P.; Stuchbery, A.E.; Poletti, S.J.; Gerl, J.; Lewis, P.M.

    1985-03-01

    The results of g-factor measurements of high spin states in 211 Rn are: Esub(x)=8856+Δsup(') keV (Jsup(π)=63/2 - ), g=0.626(7); 6101+Δsup(') keV (49/2 + ), 0.766(8); 5247+Δsup(') keV (43/2 - ), 0.74(2); 3927+Δsup(') keV (35/2 + ), 1/017(12); 1578+Δsup(') keV (17/2 - ), 0.912(9). These results together with measured E3 transition strengths and shell model calculations are used to assign configurations to the core excited states in 211 Rn. Mixed configurations are required to explain the g-factors and enhanced E3 strengths simultaneously

  5. Magnetic moments, E3 transitions and the structure of high-spin core excited states in 211Rn

    International Nuclear Information System (INIS)

    Poletti, A.R.; Dracoulis, G.D.; Byrne, A.P.; Stuchbery, A.E.; Poletti, S.J.; Gerl, J.; Lewis, P.M.

    1985-01-01

    The results of g-factor measurements of high-spin states in 211 Rn are: Esub(x)=8856+Δ' keV (Jsup(π)=63/2 - ), g=0.626(7); 6101+Δ' keV (49/2 + ), 0.766(8); 5347+Δ' keV (43/2 - ), 0.74(2); 3927+Δ keV (35/2 + ), 1.017(12); 1578+Δ keV (17/2 - ), 0.912(9). These results together with measured E3 transition strengths and shell model calculations are used to assign configurations to the core excited states in 211 Rn. Mixed configurations are required to explain the g-factors and enhanced E3 strengths simultaneously. (orig.)

  6. Quantum phase transition in the U(4) vibron model and the E(3) symmetry

    International Nuclear Information System (INIS)

    Zhang Yu; Hou Zhanfeng; Chen Huan; Wei Haiqing; Liu Yuxin

    2008-01-01

    We study the details of the U(3)-O(4) quantum phase transition in the U(4) vibron model. Both asymptotic analysis in the classical limit and rigorous calculations for finite boson number systems indicate that a second-order phase transition is still there even for the systems with boson number N ranging from tens to hundreds. Two kinds of effective order parameters, including E1 transition ratios B(E1:2 1 →1 1 )/B(E1:1 1 →0 1 ) and B(E1:0 2 →1 1 )/B(E1:1 1 →0 1 ), and the energy ratios E 2 1 /E 0 2 and E 3 1 /E 0 2 are proposed to identify the second-order phase transition in experiments. We also found that the critical point of phase transition can be approximately described by the E(3) symmetry, which persists even for moderate N∼10 protected by the scaling behaviors of quantities at the critical point. In addition, a possible empirical example exhibiting roughly the E(3) symmetry is discussed

  7. Spectroscopy of 215Ra: the shell model and enhanced E3 transitions

    International Nuclear Information System (INIS)

    Stuchbery, A.E.; Dracoulis, G.D.; Kibedi, T.; Fabricius, B.; Lane, G.J.; Poletti, A.R.; Baxter, A.M.

    1998-01-01

    Excited states in the N=127 nucleus 215 Ra have been studied using γ-ray and electron spectroscopy following reactions of 13 C on 206 Pb targets. Levels were identified up to spins of ∝61/2 ℎ and excitation energies of ∝6 MeV. Enhanced octupole transitions are a feature of the level scheme. Lifetimes and magnetic moments were measured for several isomeric levels. The level scheme, transition rates and magnetic moments are compared with empirical shell model calculations and multiparticle octupole-coupled shell model calculations. In general, the experimental data are well described, but in comparison with its success in describing enhanced E3 transitions between related states in the radon isotopes, some limitations of the multiparticle octupole-coupling approach are revealed in 215 Ra. (orig.)

  8. Reduced electric-octupole transition probabilities, B(E3;O1+ → 31-), for even-even nuclides throughout the periodic table

    International Nuclear Information System (INIS)

    Spear, R.H.

    1988-11-01

    Adopted values for the excitation energy, E x( 3 1 - ), of the first 3 - state of the even-even nuclei are tabulated. Values of the reduced electric-octupole transition probability, B(E3;O 1 + → 3 1 - ), from the ground state to this state, as determined from Coulomb excitation, lifetime measurements, inelastic electron scattering, deformation parameters β 3 obtained from angular distributions of inelastically scattered nucleons and light ions, and other miscellaneous procedures are listed in separate Tables. Adopted values for B(E3; O 1 + → 3 1 - ) are presented in Table VII, together with the E3 transition strengths, in Weisskopf units, and the product E x( 3 1 - ) x B(E3; O 1 + → 3 1 - - ) expressed as a percentage of the energy-weighted E3 sum-rule strength. An evaluation is made of the reliability of B(E3; O 1 + → 3 1 - ) values deduced from deformation parameters β 3 . The literature has been covered to March 1988

  9. Electric Monopole Transition Strengths in 62Ni

    Directory of Open Access Journals (Sweden)

    Evitts L. J.

    2016-01-01

    Full Text Available Excited states in 62Ni were populated with a (p, p’ reaction using the 14UD Pelletron accelerator at the Australian National University. Electric monopole transition strengths, ρ2(E0, were measured through simultaneous detection of the internal conversion electrons and γ rays emitted from the de-excitation of populated states, using the Super-e spectrometer coupled with a germanium detector. The strength of the 02+ to 01+ transition has been measured to be 77−34+23 × 10−3 and agrees with previously reported values. Upper limits have been placed on the 03+ to 01+ and 03+ to 02+ transitions. The measured ρ2(E0 value of the 22+ to 21+ transition in 62Ni has been measured for the first time and found to be one of the largest ρ2(E0 values measured to date in nuclei heavier than Ca. The low-lying states of 62Ni have previously been classified as one- and two-phonon vibrational states based on level energies. The measured electric quadrupole transition strengths are consistent with this interpretation. However as electric monopole transitions are forbidden between states which differ by one phonon number, the simple harmonic quadrupole vibrational picture is not suffcient to explain the large ρ2(E0 value for the 22+ to 21+ transition.

  10. Electric Monopole Transition Strengths in 62Ni

    Science.gov (United States)

    Evitts, L. J.; Garnsworthy, A. B.; Kibédi, T.; Moukaddam, M.; Alshahrani, B.; Eriksen, T. K.; Holt, J. D.; Hota, S. S.; Lane, G. J.; Lee, B. Q.; McCormick, B. P.; Palalani, N.; Reed, M. W.; Stroberg, S. R.; Stuchbery, A. E.

    2016-09-01

    Excited states in 62Ni were populated with a (p, p') reaction using the 14UD Pelletron accelerator at the Australian National University. Electric monopole transition strengths, ρ2(E0), were measured through simultaneous detection of the internal conversion electrons and γ rays emitted from the de-excitation of populated states, using the Super-e spectrometer coupled with a germanium detector. The strength of the 02+ to 01+ transition has been measured to be 77-34+23 × 10-3 and agrees with previously reported values. Upper limits have been placed on the 03+ to 01+ and 03+ to 02+ transitions. The measured ρ2(E0) value of the 22+ to 21+ transition in 62Ni has been measured for the first time and found to be one of the largest ρ2(E0) values measured to date in nuclei heavier than Ca. The low-lying states of 62Ni have previously been classified as one- and two-phonon vibrational states based on level energies. The measured electric quadrupole transition strengths are consistent with this interpretation. However as electric monopole transitions are forbidden between states which differ by one phonon number, the simple harmonic quadrupole vibrational picture is not suffcient to explain the large ρ2(E0) value for the 22+ to 21+ transition.

  11. Properties of 15/2- states in 215Ra and 217Th; evaluation of the 15/2- to 9/2+ E3 strength in N=127 isotones

    International Nuclear Information System (INIS)

    Dracoulis, G.D.; Riess, R.; Stuchbery, A.E.; Bark, R.A.; Gupta, S.L.; Baxter, A.M.; Kruse, M.

    1988-01-01

    The lifetime of the yrast 15/2 - state in 215 Ra was measured using pulsed beams and γ-ray and electron techniques. Transition multipolarities were established from measured conversion coefficients. The B(E3) of the 15/2 - → 9/2 + transition is found to be considerably larger than previously reported. A candidate for the corresponding transition in 217 Th was also observed. The E3 strength of the 15/2 - → 9/2 + transition in the N=127 isotones is evaluated in the light of these and other recent results. Interpretation in the framework of particle-octupole vibration coupling requires a systematic lowering of the core 3 - vibration as proton pairs are added to 208 Pb

  12. Collision strengths for transitions in Ni XIX

    Indian Academy of Sciences (India)

    4l configurations of Ni XIX, for which flexible atomic code. (FAC) has been ... atomic data (namely energy levels, radiative rates, collision strengths, excitation rates, etc.) ... Zhang and Sampson, who adopted the Coulomb–Born-exchange.

  13. Electric Monopole Transition Strengths in the Stable Nickel Isotopes

    Science.gov (United States)

    Evitts, Lee John

    A series of measurements of stable nickel isotopes were performed at the Australian National University in Canberra. Excited states in 58,60,62Ni were populated via inelastic scattering of proton beams delivered by the 14UD Pelletron accelerator. Multiple setups were used in order to determine the structure of low-lying states. The CAESAR array of Compton-suppressed HPGe detectors was used to measure the (E2/M1) mixing ratio of transitions from angular distributions of gamma rays. The Super-e spectrometer was used to measure conversion coefficients for a number of J to J transitions. The data obtained from both devices was combined with previously measured parent lifetimes and branching ratios to determine E0 transition strengths between J-pi transitions. The E0 transition strength for the second 0+ to first 0+ transitions in 60,62Ni have been measured for the first time through internal conversion electron detection. The experimental value of 132(+59,-70) for 62Ni agrees within 2 sigma of the previous result obtained from internal pair formation. However it is likely that the previous experimental results used an outdated theoretical model for internal pair formation emission. This work also represents the first measurements of E0 transition strengths between 2+ states in Ni isotopes. There is generally large E0 strength between the 2+ states, particularly in the second 2+ to first 2+ transition, however there is also a large uncertainty in the measurements owing to the difficulties involved in measuring conversion coefficients. In 62Ni, the E0 transition strength of 172(+62,-77) for the second 2+ to first 2+ transition gives further weight to the argument against the spherical vibrator model, as an E0 transition is forbidden if there is a change of only one phonon. The large measurement also indicates the presence of shape coexistence, complementing the recent experimental work carried out in the neutron-rich Ni isotopes.

  14. Random matrix theory for transition strengths: Applications and open questions

    Science.gov (United States)

    Kota, V. K. B.

    2017-12-01

    Embedded random matrix ensembles are generic models for describing statistical properties of finite isolated interacting quantum many-particle systems. A finite quantum system, induced by a transition operator, makes transitions from its states to the states of the same system or to those of another system. Examples are electromagnetic transitions (then the initial and final systems are same), nuclear beta and double beta decay (then the initial and final systems are different) and so on. Using embedded ensembles (EE), there are efforts to derive a good statistical theory for transition strengths. With m fermions (or bosons) in N mean-field single particle levels and interacting via two-body forces, we have with GOE embedding, the so called EGOE(1+2). Now, the transition strength density (transition strength multiplied by the density of states at the initial and final energies) is a convolution of the density generated by the mean-field one-body part with a bivariate spreading function due to the two-body interaction. Using the embedding U(N) algebra, it is established, for a variety of transition operators, that the spreading function, for sufficiently strong interactions, is close to a bivariate Gaussian. Also, as the interaction strength increases, the spreading function exhibits a transition from bivariate Breit-Wigner to bivariate Gaussian form. In appropriate limits, this EE theory reduces to the polynomial theory of Draayer, French and Wong on one hand and to the theory due to Flambaum and Izrailev for one-body transition operators on the other. Using spin-cutoff factors for projecting angular momentum, the theory is applied to nuclear matrix elements for neutrinoless double beta decay (NDBD). In this paper we will describe: (i) various developments in the EE theory for transition strengths; (ii) results for nuclear matrix elements for 130Te and 136Xe NDBD; (iii) important open questions in the current form of the EE theory.

  15. Effect of symmetry breaking on transition strength distributions

    International Nuclear Information System (INIS)

    Mitchell, G.E.; Shriner, J.F. Jr.

    2001-01-01

    The quantum numbers of over 100 states in 30 P have been determined from the ground state to 8 MeV. Previous measurements had provided complete spectroscopy in 26 Al. For these N=Z=odd nuclei, states of isospin T=0 and T=1 coexist at all energies. These spectra provide a unique opportunity to test the effect of symmetry breaking (of the approximate symmetry isospin) on the level statistics and on the transition strength distributions. The level statistics are strongly affected by the small symmetry breaking and the transition strength distributions differ from the Porter-Thomas distribution

  16. Transition-strength fluctuations and the onset of chaotic motion

    International Nuclear Information System (INIS)

    Alhassid, Y.; Levine, R.D.

    1986-01-01

    The maximum-entropy formalism is used to characterize the fluctuations in transition strengths for a bound quantum-mechanical system. In the chaotic limit only one, ever present, sum rule is required as a constraint. The resulting distribution is that of Porter and Thomas, which can also be derived from random-matrix theory. For nonchaotic systems the distribution of transition strengths has a lower entropy. A possible additional constraint, operative during the onset of chaos, is proposed. The distribution of maximal entropy subject to both constraints accords with computed intensities in a system of two degrees of freedom

  17. Oscillator strengths and transition probabilities for the intercombination transitions in Fe XXII

    International Nuclear Information System (INIS)

    Glass, R.

    1979-01-01

    Oscillator strengths and transition probabilities are evaluated for the intercombination transitions between the 2s 2 2p, 2s 2p 2 and 2p 3 states of Fe XXII using configuration interaction wavefunctions. The fine-structure splittings have also been calculated. Some significant differences with previous calculations are obtained

  18. Collision strengths for dipole-allowed transitions in S II

    International Nuclear Information System (INIS)

    Ho, Y.K.; Henry, R.J.W.

    1990-01-01

    Calculations of collision strengths for electron-impact excitations of S II from the ground state 3p3 4S0 to excited states 3p4 4P, 3d 4F, 3d 4D, 4s 4P, and 3d 4P were carried out using the R-matrix code described by Berrington et al. (1978) and the NIEM code described by Henry et al. (1981). Results are presented for the thermally averaged collision strengths for the five-state and six-state calculations. Convergence behaviors were examined by comparison with the six-state calculations and the previously obtained two-state calculations. Uncertainties for these transitions were estimated to be within 20 percent, except for the 4S0 - 3p4 4P transition in which a 40 percent uncertainty was estimated. 22 refs

  19. Oscillator strengths and radiative rates for transitions in neutral sulfur

    International Nuclear Information System (INIS)

    Deb, N.C.; Hibbert, A.

    2008-01-01

    We present accurate oscillator strengths and radiative rates for 2173 E1 transitions among the 120 levels belonging to 3s 2 3p 4 , 3s3p 5 , and 3s 2 3p 3 ( 4 S o , 2 D o , 2 P o )nl configurations where nl=4s,5s,6s,4p,5p,6p,3d,4d,4f,5f. A configuration interaction approach is employed through the standard CIV3 program. The 114 LS states included in the present calculation generate 250 fine-structure levels belonging to the above configurations below 100,000 cm -1 . However, results of only 120 fine-structure levels are presented due to the absence of experimental energy values for the remaining levels. Tabulations of oscillator strengths and radiative rates, and their comparison with other calculations, are presented in the first two tables. In a separate table the oscillator strengths and transition probabilities, in length and velocity gauges, are presented for 2173 E1 transitions, and are arranged in ascending order of wavelength

  20. Strength distribution of γ-transitions deexciting superdeformed rotational bands

    International Nuclear Information System (INIS)

    Lopez-Martens, A.P.; Doesing, T.; Khoo, T.L.; Korichi, A.; Hannachi, F.; Calderin, I.J.; Lauritsen, T.; Ahmad, I.; Carpenter, M.P.; Fischer, S.M.; Hackman, G.; Janssens, R.V.F.; Nisius, D.; Reiter, P.; Amro, H.; Moore, E.F.

    1999-01-01

    The strength distribution of the γ rays in the decay-out from superdeformed (SD) states is investigated by applying the maximum likelihood method, with special emphasis on the influence of the lower threshold given by experimental conditions. Clear graphical solutions are found, and a careful estimation of the dispersion in the values of the number of degrees of freedom and of the average strength of the most likely χ 2 distribution is carried out. For the 194 Hg nucleus, 41 primary transitions from the decay-out of SD states are identified above 2600 keV. It is concluded that they represent the strongest 10% of the transitions selected stochastically from a Porter-Thomas distribution. This would support the scenario of a statistical decay of SD states via coupling to a compound state at normal deformation. However, the occurrence of several very strong direct one-step transitions as previously observed in 194 Hg has a very small probability of the order of 10 -4 . This may indicate special selection rules governing the decay. However, based on the absence of strong primary transitions from SD states in adjacent nuclei, the situation in 194 Hg is viewed as a very lucky incidence

  1. Enhanced E3 transitions and mixed configurations for core excited isomers in 210At and 211At

    International Nuclear Information System (INIS)

    Dracoulis, G.D.; Steed, C.A.; Byrne, A.P.; Poletti, S.J.; Stuchbery, A.E.; Bark, R.A.

    1986-09-01

    The lifetime and branching ratio of the 19 + isomer in 210 At have been measured. Its enhanced E3 decay and g-factor, and those of the related 39/2 - isomer in 211 At are compared with the results of a semi-empirical shell model calculation which includes couplings to the 3 - octupole vibration, resulting in mixed configurations. Lifetimes were also obtained for the 15 - isomer in 210 At, and he 29/2 + isomer in 209 At

  2. Strengths of gamma-ray transitions in A = 6–44 nuclei (III)

    NARCIS (Netherlands)

    Endt, P.M.

    The present tables list the strengths (in Weisskopf units) of over 2400 γ-ray transitions in A = 6–44 nuclei, classified according to character (electric or magnetic, multipolarity, isospin forbiddenness). Selected transitions from unbound states are included. The strengths for isovector E1 and M1

  3. Strength distributions of electromagnetic transitions in light nuclei

    International Nuclear Information System (INIS)

    Kostin, V.Ya.; Koval', A.A.; Kopanets, E.G.; Tsytko, S.P.

    1980-01-01

    Distributions of probabilities of electromagnetic transitions from resonance levels of light nuclei with masses A=Z-40 for eight types of transition (epsilon1, epsilon2, M1, M8, isoscalar and isovector) are obtained. Recommended upper limits (RUL) of transition probabilities are determined for each type of transitions. A comparison with analogous characteristics for transitions between bound states is carried out. It has been causes found that RUL for resonance states substantially differ from RUL for transitions between bound states. Possible causes of such difference are discussed

  4. COLLISION STRENGTHS AND EFFECTIVE COLLISION STRENGTHS FOR TRANSITIONS WITHIN THE GROUND-STATE CONFIGURATION OF S III

    Energy Technology Data Exchange (ETDEWEB)

    Hudson, C. E.; Ramsbottom, C. A.; Scott, M. P., E-mail: c.hudson@qub.ac.uk, E-mail: c.ramsbottom@qub.ac.uk, E-mail: p.scott@qub.ac.uk [Department of Applied Maths and Theoretical Physics, The Queen' s University of Belfast, Belfast BT7 1NN (United Kingdom)

    2012-05-01

    We have carried out a 29-state R-matrix calculation in order to calculate collision strengths and effective collision strengths for the electron impact excitation of S III. The recently developed parallel RMATRX II suite of codes have been used, which perform the calculation in intermediate coupling. Collision strengths have been generated over an electron energy range of 0-12 Ryd, and effective collision strength data have been calculated from these at electron temperatures in the range 1000-100,000 K. Results are here presented for the fine-structure transitions between the ground-state configurations of 3s {sup 2}3p {sup 23} P{sub 0,1,2}, {sup 1}D{sub 2}, and {sup 1} S{sub 0}, and the values given resolve a discrepancy between two previous R-matrix calculations.

  5. E3 Staff Database

    Data.gov (United States)

    US Agency for International Development — E3 Staff database is maintained by E3 PDMS (Professional Development & Management Services) office. The database is Mysql. It is manually updated by E3 staff as...

  6. The empirical connection between (p,n) cross sections and beta decay transition strengths

    International Nuclear Information System (INIS)

    Taddeucci, T.N.

    1988-01-01

    A proportionality is assumed to exist between 0/degree/ (p,n) cross sections and the corresponding beta decay transition strengths. The validity of this assumption is tested by comparison of measured (p,n) cross sections and analogous beta decay strengths. Distorted waves impulse approximation calculations also provide useful estimates of the accuracy of the proportionality relationship. 14 refs., 10 figs

  7. Determination of the B(E3,0$^{+}$ $\\rightarrow$ 3$^{-}$) strength in the octupole correlated nuclei $^{142,144}$Ba using Coulomb excitation

    CERN Multimedia

    We propose to exploit the unique capability of ISOLDE to provide intense post-accelerated $^{142}$Ba and $^{144}$Ba ion beams from the HIE-ISOLDE facility to enable the Coulomb excitation of the first 3$^-$ state in these nuclei. By measuring the $\\gamma$-ray yields of the E1 decays from the 3$^-$ state using the MINIBALL array, we can obtain the interesting transition matrix element. The results will give quantitative information about octupole correlations in these nuclei.

  8. Determination of the B(E3;0$^+\\!\\rightarrow$ 3$^{-}$) strength in the octupole correlated nucleus $^{144}$Ba using Coulomb excitation

    CERN Multimedia

    We propose to exploit the unique capability of ISOLDE to provide intense post-accelerated $^{144}$Ba ion beams from the REX facility to enable the Coulomb excitation of the first 3$^{-}$ state in this nucleus. By measuring the $\\gamma$-ray yields of the E1 decay connecting the 3$^{-}$ and 2$^{+}$ states using the MINIBALL array, we can obtain the interesting transition matrix element. The result will give quantitative information about octupole correlations in this nucleus. We require 27 shifts to fulfill the aims of the experiment.

  9. Garnet Yield Strength at High Pressures and Implications for Upper Mantle and Transition Zone Rheology

    International Nuclear Information System (INIS)

    Kavner, A.

    2008-01-01

    Garnet helps control the mechanical behavior of the Earth's crust, mantle, and transition zone. Here, measurements are presented suggesting that garnet, long considered to be a high-viscosity phase, is actually weaker than the other dominant components in the transition zone. The mechanical behavior of garnet at high pressures was examined using radial diffraction techniques in the diamond anvil cell. The yield strength of grossular garnet was inferred from synchrotron X-ray measurements of differential lattice strains. The differential stress was found to increase from 1.3 (±0.6) GPa at a hydrostatic pressure 5.8 (±1.1) GPa to 4.1 (±0.4) GPa at 15.7 (±1.0) GPa, where it was level to 19 GPa. The strength results are consistent with inferred strength values for majorite garnet from measurements in the diamond cell normal geometry, bolstering the idea that garnet-structured materials may all have similar strengths. In this low-temperature, high differential stress regime, garnet is shown to be significantly weaker than anhydrous ringwoodite and to have a strength similar to hydrous ringwoodite. This result suggests that the presence of water in the transition zone may not be required to explain a weak rheology, and therefore models of transition zone behavior built assuming that garnet is the high-strength phase may need to be revised.

  10. Dependence of dipole transition gamma ray strength on the type of nucleus

    International Nuclear Information System (INIS)

    Cojocaru, V.; Stefanescu, Irina; Popescu, I.V.; Badica, T.; Olariu, A.

    2000-01-01

    The strength of gamma-ray transition is defined as the ratio between the experimental radiative width Γ γ and the theoretical radiative width calculated according to a model (for example Weisskopf single particle model, Γ W ). It is important to know on which parameters this strengths depend. In our previous work we put in evidence the dependence of the dipole transition gamma-ray strengths on the type of the nucleus. In this paper we look for a possible dependence of the quadrupole gamma-ray strengths on the type of nucleus (doubly-even, doubly-odd, with odd proton number and odd neutron number). All the input data are taken from the National Nuclear Data Center, Brookhaven. In order to demonstrate this possible dependence one can use the average of the strongest 10% transitions of given character. As the A dependence is concerned we use the following A-regions: 6-20, 21-44, 45-90, 91-150, 151-200. An average value for these transitions is also plotted both for the E2 and M2 transitions. Generally, all the functions log 10 vs A (S=Γ γ /Γ W ) have the same pattern as 'total' put in evidence by Endt. Moreover, there is a clear difference in the most A regions of the average S 10 values for different types of nuclei. As the RUL (Recommended Upper Limits W.u.) are concerned they have to be established as the highest experimental values of the transition strengths. In this work we suggest new RUL but this time in connection with the type of the nucleus. A table with the RUL depending on the nuclear type, for E2 and M2 transitions, respectively, is given. The number of M2 transitions is quite small. In this case, one might set the recommended upper limits with some precaution. (authors)

  11. Acrylate oligomers in ultraviolet cured PSA's glass transition, molecular weight versus peel strength

    International Nuclear Information System (INIS)

    Miller, H.C.

    1999-01-01

    Typically those not skilled in the art relate Glass Transition Temperature to Pressure Sensitive Adhesives. You need a low Tg material to prepare good pressure sensitive adhesives. This report deals with a wide range acrylate terminated oligomers in a standard formulation. Molecular weight, chemical structure variations are examined versus the Glass Transition of the oligomers and final peel strength. Each formulated adhesive will require unique oligomer properties to reach one hundred newtons per 100 millimeters (5.71 pounds per square inch) peel strength. Excellent peel strengths may be obtained with oligomer molecular weight ranging from six thousand to one thousand molecular weight and glass transition temperatures ranging from minus seventy four degrees centigrade up to thirteen degrees centigrade

  12. Fine-structure energy levels, oscillator strengths and transition probabilities in Ni XVI

    International Nuclear Information System (INIS)

    Deb, N.C.; Msezane, A.Z.

    2001-01-01

    Fine-structure energy levels relative to the ground state, oscillator strengths and transition probabilities for transitions among the lowest 40 fine-structure levels belonging to the configurations 3s 2 3p, 3s3p 2 , 3s 2 3d, 3p 3 and 3s3p3d of Ni XVI are calculated using a large scale CI in program CIV3 of Hibbert. Relativistic effects are included through the Breit-Pauli approximation via spin-orbit, spin-other-orbit, spin-spin, Darwin and mass correction terms. The existing discrepancies between the calculated and measured values for many of the relative energy positions are resolved in the present calculation which yields excellent agreement with measurement. Also, many of our oscillator strengths for allowed and intercombination transitions are in very good agreement with the recommended data by the National Institute of Standard and Technology (NIST). (orig.)

  13. Prediction of the oscillator strengths for the electric dipole transitions in Th II

    Energy Technology Data Exchange (ETDEWEB)

    Dembczynski, Jerzy [Institute of Control and Information Engineering, Faculty of Electrical Engineering, Poznan University of Technology, Piotrowo 3A, 60-965 Poznan (Poland); Ruczkowski, Jaroslaw; Elantkowska, Magdalena [Laboratory of Quantum Engineering and Metrology, Faculty of Technical Physics, Poznan University of Technology, Nieszawska 13B, 60-965 Poznan (Poland)

    2014-07-01

    In order to parametrize the oscillator strength, the matrix of angular coefficients of the possible transitions in multiconfiguration system were calculated. In the odd and even configuration systems, the fine structure eigenvectors for both parities were obtained, using our semiempirical method, which taken into account also the second order effects, resulting from the excitations from electronic closed shells to open shells and from open shells to empty shell. The correctness of the fine structure wave functions was verified by the comparison of calculated and experimental hyperfine structure constants for Th II available in the literature. The least square fit to experimental values for some transitions allow to obtain the values of radial parameters and predict the oscillator strengths values for all possible transitions from the levels under consideration. These calculations are necessary for the design of the nuclear frequency standard based on the thorium ion.

  14. Policies and Predictions for a Low-Carbon Transition by 2050 in Passenger Vehicles in East Asia: Based on an Analysis Using the E3ME-FTT Model

    Directory of Open Access Journals (Sweden)

    Aileen Lam

    2018-05-01

    Full Text Available In this paper we apply a model of technological diffusion, Future Technology Transformations in the Transport Sector (FTT: Transport, linked to the E3ME macroeconomic model, to study possible future technological transitions in personal passenger transport in four East Asian countries. We assess how targeted policies could impact on these transitions by defining four scenarios based on policies that aim to reduce emissions from transport. For each country we find that an integrated approach of tax incentives, subsidies, regulations (fuel economy efficiency, kick-start programs and biofuel programs yield the most significant emission reductions because, when combined, they accelerate effectively the diffusion of electric vehicles in the region.

  15. Flat punch adhesion: transition from fracture-based to strength-limited pull-off

    International Nuclear Information System (INIS)

    Jiang, Yijie; Turner, Kevin T; Grierson, David S

    2014-01-01

    The adhesion of a cylindrical flat punch to a surface due to interatomic forces is a well-known problem that is important in many applications, including indentation experiments and the adhesion of fibrillar structures. Traditionally, the pull-off force has been related to the work of adhesion and punch geometry via the Kendall solution that uses a Griffith energy balance to assess crack propagation and pull-off. More recently, it has been shown that under certain conditions, notably at small punch diameters, the contact can behave in a ‘strength-limited’ fashion in which the interface separates uniformly rather than via crack propagation. Here, a Maugis-Dugdale-type analysis of power-law-shaped bodies in contact is used to examine the change in behaviour from the fracture-based Kendall solution to strength-limited pull-off for cylindrical flat punches. The transition from fracture-based to strength-limited behaviour is described in terms of a non-dimensional parameter that is similar to previous quantities used to describe the transition and is a function of the punch size, the elasticity of the contact, and the adhesion properties. The results of this relatively simple analysis compare favourably with results from more complex computational simulations. In addition, the results are used to develop a function that quantifies the transition between the Kendall solution and the strength-limited solution in order to facilitate interpretation of adhesion measurements in the transition regime between the two limits. Finally, the power-law analysis is used to assess the sensitivity of the transition to the exact shape of the punch. (paper)

  16. Oscillator strengths for transitions among Fe III levels belonging to the three lowest configurations

    International Nuclear Information System (INIS)

    Deb, N C; Hibbert, A

    2008-01-01

    Accurate oscillator strengths and Einstein A-coefficients for some El and E2 transitions among 3d 6 , 3d 5 4s and 3d 5 4p levels of FeIII are presented and compared with other available results. The present results comprise by far the largest configuration interaction calculation for this astrophysically important ion, and include relativistic effects through the Breit-Pauli operator. The core-valence effects from a large number of 3d 6 and 3d 5 cores are carefully treated by optimising 4d, 4f, 5s, 5p, 5d, 5f and 6p orbitals either as a correction or as a correlation orbital while 1s, 2s, 2p, 3s, 3p and 3d Hartree-Fock functions are used. The 4s and 4p functions are optimised as spectroscopic orbitals. Fine-tuning of the ab initio energies was done through adjusting by a small amount some diagonal elements of the Hamiltonian matrix. It is found that for many of the relatively strong dipole transitions, our calculated oscillator strengths agree with available calculations, while for the weaker transitions our results often disagree with the previously determined results. We also present gA values for five E2 transitions for the multiplets 3d 6 5 DJ → 3d 5 ( 6 S)4s 5 S 2. The present results for these transitions show a 30-40% increase over the results previously published.

  17. Large enhancement of radiative strength for soft transitions in the quasicontinuum.

    Science.gov (United States)

    Voinov, A; Algin, E; Agvaanluvsan, U; Belgya, T; Chankova, R; Guttormsen, M; Mitchell, G E; Rekstad, J; Schiller, A; Siem, S

    2004-10-01

    Radiative strength functions (RSFs) for the (56,57)Fe nuclei below the separation energy are obtained from the 57Fe(3He,alphagamma)56Fe and 57Fe(3He,3He'gamma)57Fe reactions, respectively. An enhancement of more than a factor of 10 over common theoretical models of the soft (E(gamma) less than or approximately equal 2 MeV) RSF for transitions in the quasicontinuum (several MeV above the yrast line) is observed. Two-step cascade intensities with soft primary transitions from the 56Fe(n,2gamma)57Fe reaction confirm the enhancement.

  18. E2 and M1 transition strengths in heavy deformed nuclei revisited

    International Nuclear Information System (INIS)

    Draayer, J.P.; Popa, G.; Hirsch, J.G.; Vargas, C.E.

    2003-01-01

    An update on the status of pseudo-SU(3) shell-model calculations in strongly deformed nuclei in the rare earth region is presented. Representative results for energy levels as well as E2 (quadrupole) and M1 (scissors) transitions strengths in 162 Dy (even-even) and 163 Dy (odd-mass) are given. The calculations use realistic single-particle energies and quadrupole-quadrupole and pairing interaction strengths fixed from systematics. The strengths of rotor-like terms included in the Hamiltonian- all small relative to the other terms in the interaction were adjusted to give an overall best fit to the energy spectra. The results present a paradox: for even-even nuclei (integer angular momentum) non-zero pseudo-spin configurations seems to be unimportant while for the odd-mass systems (half-integer angular momentum) pseudo-spin mixing is essential as spin-flip couplings appear to dominate the M1 transition strengths. (Author)

  19. Effect of transition metal impurities on the strength of grain boundaries in vanadium

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Xuebang; Kong, Xiang-Shan; You, Yu-Wei; Liu, Wei; Liu, C. S., E-mail: csliu@issp.ac.cn [Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, P.O. Box 1129, Hefei 230031 (China); Chen, Jun-Ling; Luo, G.-N. [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China)

    2016-09-07

    Effects of 3d (Ti-Ni), 4d (Zr-Pd), and 5d (Hf-Pt) transition metal impurities on strength of two representative vanadium grain boundaries (GBs), symmetric Σ3(111) and asymmetric Σ5(210), were studied by first-principles calculations within the framework of the Rice-Wang thermodynamic model and within the computational tensile test. The desirable elements to increase the GB cohesion were predicted based on their segregation and strengthening behaviors across the different GB sites. It reveals that the elements Ti, Zr, Hf, Nb, and Ta are good choices for the GB cohesion enhancers. In addition, the GB strengthening by solutes is sensitive to the GB structures. The elements Cr, Mn, Fe, Co, and Ni decrease the GB strength of the Σ3(111) GB but they can increase the cohesion of the Σ5(210) GB. Furthermore, the origin of Ti-induced change of the GB strength was uncovered by analyzing the atomic bonds and electronic structures as well as the tensile strength. This work provides a theoretical guidance to screen promising alloying elements in V-based materials with improved resistance to GB decohesion and also helps us to understand the formation mechanism of Ti-rich precipitates in the V-Cr-Ti alloys under neutron or ion irradiation environments.

  20. Oscillator strengths and branching fractions of 4d75p-4d75s Rh II transitions

    Science.gov (United States)

    Bouazza, Safa

    2017-01-01

    This work reports semi-empirical determination of oscillator strengths, transition probabilities and branching fractions for Rh II 4d75p-4d75s transitions in a wide wavelength range. The angular coefficients of the transition matrix, beforehand obtained in pure SL coupling with help of Racah algebra are transformed into intermediate coupling using eigenvector amplitudes of these two configuration levels determined for this purpose; The transition integral was treated as free parameter in the least squares fit to experimental oscillator strength (gf) values found in literature. The extracted value: 5s|r1|4d75p> =2.7426 ± 0.0007 is slightly smaller than that computed by means of ab-initio method. Subsequently to oscillator strength evaluations, transition probabilities and branching fractions were deduced and compared to those obtained experimentally or through another approach like pseudo-relativistic Hartree-Fock model including core-polarization effects.

  1. Distribution of spin dipole transition strength in the 15N(n,p)15C reaction

    International Nuclear Information System (INIS)

    Cellar, A.; Alford, W.P.; Helmer, R.; Abegg, R.; Frekers, D.; Haeusser, O.; Henderson, R.S.; Jackson, K.P.; Vetterli, M.; Yen, S.; Jeppesen, R.; Larson, B.; Mildenberger, J.; Pointon, B.W.; Trudel, A.

    1990-08-01

    The reaction 15 N(n,p) 15 C was studied at a neutron energy of 288 MeV using the TRIUMF (n,p) charge exchange facility and a high pressure gas target. The angular distributions for spin dipole (ΔL=1) transitions to the states in 15 C at energies 0 MeV and 0.740 MeV, as well as for higher excitation energies, were measured and the results were compared with DWIA calculations. The measured distribution of the spin dipole strength agrees well with shell model predictions, indicating that a rather simple model provides a satisfactory description of the 15 N ground state, and of positive parity states in 15 C up to about 18 MeV excitation. The magnitude of the peak cross sections (at ≅ 7 degrees) is described well by the calculations when the theoretical cross section is renormalized by a factor 0.7. The calculated cross sections near zero degrees are generally smaller than experimental data. It this is a general feature of ΔL=1 transitions, it suggests that estimates of GT strength based on a multipole decomposition of measured cross sections may be too high. (Author) (41 refs., 3 tabs., 14 figs.)

  2. Strength functions of primary transitions following thermal neutron capture in strontium

    International Nuclear Information System (INIS)

    Winter, C.; Lieb, K.P.

    1989-01-01

    The primary E1, M1 and E2 γ-radiation in 87,88,89 Sr observed after thermal neutron capture was compared with the predictions of single particle and giant resonance models. The nuclei feature a wide range of neutron binding energies between 6.3 and 11.1 MeV, which makes a 5.5 MeV spectrum of primary transition energies available for investigation. The (n, γ) reaction was used to estimate the parameters of the spin-flip M1 giant resonance in strontium. The total energy weighted M1 strength of this resonance exceeds the results of shell model and random phase approximation calculations for 90 Zr by a factor of 3-4. The E1 strengths were found to agree with the established giant dipole resonance model. The few data on primary E2 transitions do not allow to differentiate between the giant quadrupole resonance and the single particle models. (orig.)

  3. High-spin yrast isomers in 211Rn and 212Rn with enhanced E3 decays

    International Nuclear Information System (INIS)

    Dracoulis, G.D.; Byrne, A.P.; Fabricius, B.

    1990-01-01

    New isomeric states with J π =69/2 + ,τ m = 13 (1) ns in 211 Rn and J π =33 - ,τ m = 7(1) ns in 212 Rn have been identified. They decay by enchanced E3 transitions with strengths of 33(3) and 43(6) single particle units to the known 63/2 - and 30 + isomers 211 Rn and 212 Rn, respectively. The excitation energies and transition strengths agree well with predictions of the multi-particle, octupole-vibration coupled model. 13 refs., 2 tabs., 3 figs

  4. Inter-band B(E2) transitions strengths in 160-170Dy nuclei

    International Nuclear Information System (INIS)

    Vargas, Carlos E; Lerma, Sergio; Velázquez, Víctor

    2015-01-01

    The rare earth region of the nuclear landscape is characterized by a large collectivity observed. The microscopic studies are difficult to perform in the region due to the enormous size of the valence spaces. The use of symmetries based models avoids that problem, because the symmetry allows to choose the most relevant degrees of freedom for the system under consideration. We present theoretical results for electromagnetic properties in 160-168 Dy isotopes employing the pseudo-SU(3) model. In particular, we study the B(E2) inter-band transition strengths between the ground state, γ and, β-bands. The model succesfully describes in a systematic way rotational features in these nuclei and allows to extrapolate toward the midshell nucleus 170 Dy

  5. Effect of electric field on the oscillator strength and cross-section for intersubband transition in a semiconductor quantum ring

    International Nuclear Information System (INIS)

    Bhattacharyya, S; Das, N R

    2012-01-01

    In this paper, we study the oscillator strength and cross-section for intersubband optical transition in an n-type semiconductor quantum ring of cylindrical symmetry in the presence of an electric field perpendicular to the plane of the ring. The analysis is done considering Kane-type band non-parabolicity of the semiconductor and assuming that the polarization of the incident radiation is along the axis of the ring. The results show that the oscillator strength decreases and the transition energy increases with the electric field. The assumption of a parabolic band leads to an overestimation of the oscillator strength. The effects of the electric field, band non-parabolicity and relaxation time on absorption cross-section for intersubband transition in a semiconductor quantum ring are also shown. (paper)

  6. Electron-impact excitation of Fe II: Effective collision strengths for optically allowed fine-structure transitions

    International Nuclear Information System (INIS)

    Ramsbottom, C.A.

    2009-01-01

    In this paper, we present collision strengths and Maxwellian averaged effective collision strengths for the electron-impact excitation of Fe II. We consider specifically the optically allowed lines for transitions from the 3d 6 4s and 3d 7 even parity configuration states to the 3d 6 4p odd parity configuration levels. The parallel suite of Breit-Pauli codes are utilized to compute the collision cross-sections where relativistic effects are included explicitly in both the target and the scattering approximation. A total of 100 LS or 262-jj levels formed from the basis configurations 3d 6 4s, 3d 7 and 3d 6 4p were included in the wavefunction representation of the target, including all doublet, quartet and sextet terms. The Maxwellian averaged effective collision strengths are computed across a wide range of electron temperatures from 100 to 100,000 K, temperatures of importance in astrophysical and plasma applications. A detailed comparison is made with previous works and significant differences were found to occur for some of the transitions considered. We conclude that in order to obtain converged collision strengths and effective collision strengths for these allowed transitions it is necessary to include contributions from partial waves up to L = 50 explicitly in the calculation, and in addition, account for contributions from even higher partial waves through a 'top up' procedure.

  7. Schmidt Reaction of E-3-Benzylidenechromanones and E-3-Benzylidenethiochromanones

    Directory of Open Access Journals (Sweden)

    Tapas K. Mandal

    2013-01-01

    Full Text Available On treatment with NaN3/c. H2SO4-HOAc or NaN3/TFA, E-3-benzylidenechromanones are mostly converted to E-β-aminobenzylidenechromanones while E-3-benzylidenethiochromanones are converted to 3-benzoylthiochromones. A structurally new type of product has been isolated for the reaction of E-3-benzylidene-4′-methoxychromanone with NaN3/TFA. Mechanistic paths have been suggested for formation of the products.

  8. CI+MBPT calculations of Ar I energies, g factors, and transition line strengths

    Science.gov (United States)

    Savukov, I. M.

    2018-03-01

    Excited states of noble gas atoms present certain challenges to atomic theory for several reasons: first, relativistic effects are important and LS coupling is not optimal; second, energy intervals can be quite small, leading to strong mixing of states; third, many-body perturbation theory for hole states does not converge well. Previously, some attempts were made to solve this problem, using for example the all-order coupled-cluster approach and particle-hole configuration-interaction many-body perturbation theory (CI-MBPT) with modified denominators. However, while these approaches were promising, the accuracy was still limited. In this paper, we calculate Ar I energies, g factors, and transition amplitudes using ab initio CI-MBPT with eight valence electrons to avoid the problem of slow convergence of MBPT due to strong interaction between 3p and 3s states. We also included in CI many dominant states obtained by double excitations of the ground state configuration. Thus perturbation corrections were needed only for 1s, 2s, 2p core electrons non-included in valence-valence CI, which are quite small. We found that energy, g factors, and electric dipole matrix elements are in reasonable agreement with experiments. It is noteworthy that the theory agreed well with accurately measured g factors. Experimental oscillator strengths have large uncertainty, so in some cases we made a comparison with average values.

  9. Electron-impact excitation collision strengths and theoretical line intensities for transitions in S III

    Energy Technology Data Exchange (ETDEWEB)

    Grieve, M. F. R.; Ramsbottom, C. A.; Hudson, C. E. [Centre for Theoretical Atomic, Molecular and Optical Physics, School of Mathematics and Physics, Queen' s University Belfast, Belfast, BT7 1NN (United Kingdom); Keenan, F. P., E-mail: c.ramsbottom@qub.ac.uk [Astrophysics Research Centre, School of Mathematics and Physics, Queen' s University Belfast, Belfast, BT7 1NN (United Kingdom)

    2014-01-01

    We present Maxwellian-averaged effective collision strengths for the electron-impact excitation of S III over a wide range of electron temperatures of astrophysical importance, log T{sub e} (K) = 3.0-6.0. The calculation incorporates 53 fine-structure levels arising from the six configurations—3s {sup 2}3p {sup 2}, 3s3p {sup 3}, 3s {sup 2}3p3d, 3s {sup 2}3p4s, 3s {sup 2}3p4p, and 3s {sup 2}3p4d—giving rise to 1378 individual lines and is undertaken using the recently developed RMATRX II plus FINE95 suite of codes. A detailed comparison is made with a previous R-matrix calculation and significant differences are found for some transitions. The atomic data are subsequently incorporated into the modeling code CLOUDY to generate line intensities for a range of plasma parameters, with emphasis on allowed ultraviolet extreme-ultraviolet emission lines detected from the Io plasma torus. Electron density-sensitive line ratios are calculated with the present atomic data and compared with those from CHIANTI v7.1, as well as with Io plasma torus spectra obtained by Far-Ultraviolet Spectroscopic Explorer and Extreme-Ultraviolet Explorer. The present line intensities are found to agree well with the observational results and provide a noticeable improvement on the values predicted by CHIANTI.

  10. Study of the strength distribution of primary γ-transitions in the decay from superdeformed states in 194Hg

    International Nuclear Information System (INIS)

    Lopez-Martens, A.P.; Doessing, T.; Khoo, T.L.; Korichi, A.; Hannachi, F.; Calderin, I.J.; Lauritsen, T.; Ahmad, I.; Carpenter, M.P.; Fischer, S.M.; Hackman, G.; Janssens, R.V.F.; Nisius, D.; Reiter, P.; Amro, H.; Moore, E.F.

    1999-01-01

    The strength distribution of the primary γ rays in the decay from superdeformed (SD) states is investigated by applying the maximum likelihood method. For the 194 Hg nucleus, 41 primary transitions are identified above 2600 keV. It is concluded that they represent the strongest 10% of the transitions selected stochastically from a Porter-Thomas distribution. This would support the scenario of a statistical decay of SD states via coupling to a compound state at normal deformation. However, the occurrence of several very strong 'one-step linking' transitions is found to have a very small probability. Based on the absence of strong primary transitions from SD states in adjacent nuclei, the situation in 194 Hg is viewed as a very lucky incidence

  11. Reinterpretation of the recently measured absolute generalized oscillator strength for the Ar 3p-4p transition

    International Nuclear Information System (INIS)

    Msezane, A.Z.; Felfli, Z.; Chen, Z.; Amusia, M.Ya.; Chernysheva, L. V.

    2002-01-01

    The recent experimental observation of the absolute generalized oscillator strength (GOS) for the Ar 3p-(4p,4p ' ) nondipole transition has been interpreted as a manifestation of quadrupole excitation [X. W. Fan and K. T. Leung, Phys. Rev. A 62, 062703 (2000)]. Contrary to the experimentalists' assignment, on the grounds of our random-phase-approximation with exchange (RPAE) calculation, we attribute the measured GOS to combined monopole, the dominant component, and quadrupole contributions. Our RPAE GOS's for the Ar dipole 3p-4s and 3p-3d,5s and the lowest nondipole transitions are compared with the measurements. The results could have significant implications for other similar transitions, previously interpreted as quadrupole excitation and for interpreting other discrete transitions

  12. Anomalous transition strength in the proton-unbound nucleus {sup 109}{sub 53}I{sub 56}

    Energy Technology Data Exchange (ETDEWEB)

    Procter, M.G., E-mail: mark.procter@postgrad.manchester.ac.uk [School of Physics and Astronomy, Schuster Laboratory, The University of Manchester, Manchester M13 9PL (United Kingdom); Cullen, D.M. [School of Physics and Astronomy, Schuster Laboratory, The University of Manchester, Manchester M13 9PL (United Kingdom); Department of Physics, University of Jyvaeskylae, FIN-40014 Jyvaeskylae (Finland); Scholey, C.; Ruotsalainen, P. [Department of Physics, University of Jyvaeskylae, FIN-40014 Jyvaeskylae (Finland); Angus, L. [University of The West of Scotland, High Street, Paisley PA1 2BE (United Kingdom); Baeck, T.; Cederwall, B. [Department of Physics, Royal Institute of Technology, SE-10691 Stockholm (Sweden); Dewald, A.; Fransen, C. [Institut fuer Kernphysik, Universitaet zu Koeln, D-50937, Koeln (Germany); Grahn, T. [Department of Physics, University of Jyvaeskylae, FIN-40014 Jyvaeskylae (Finland); Oliver Lodge Laboratory, University of Liverpool, Liverpool L69 7ZE (United Kingdom); Greenlees, P.T. [Department of Physics, University of Jyvaeskylae, FIN-40014 Jyvaeskylae (Finland); Hackstein, M. [Institut fuer Kernphysik, Universitaet zu Koeln, D-50937, Koeln (Germany); Jakobsson, U.; Jones, P.M.; Julin, R.; Juutinen, S.; Ketelhut, S.; Leino, M. [Department of Physics, University of Jyvaeskylae, FIN-40014 Jyvaeskylae (Finland); Liotta, R. [Department of Physics, Royal Institute of Technology, SE-10691 Stockholm (Sweden); Lumley, N.M. [School of Physics and Astronomy, Schuster Laboratory, The University of Manchester, Manchester M13 9PL (United Kingdom)

    2011-10-13

    A lifetime measurement has been made for the first excited 11/2{sup +} state in the proton-unbound nucleus {sup 109}{sub 53}I{sub 56} using the recoil-distance Doppler-shift method in conjunction with recoil-proton tagging. The experimental reduced transition probability is considerably smaller than the prediction of theoretical shell-model calculations using the CD-Bonn nucleon-nucleon potential. The discrepancy between the theoretical and experimental reduced transition strengths in this work most likely arises from the inability of the current shell-model calculations to accurately account for the behavior of the unbound nuclear states.

  13. Energy levels, oscillator strengths, line strengths, and transition probabilities in Si-like ions of La XLIII, Er LIV, Tm LV, and Yb LVI

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Zhan-Bin, E-mail: chenzb008@qq.com [College of Science, National University of Defense Technology, Changsha, Hunan 410073 (China); Ma, Kun [School of Information Engineering, Huangshan University, Huangshan 245041 (China); Wang, Hong-Jian [Chongqing Key Laboratory for Design and Control of Manufacturing Equipment, Chongqing Technology and Business University, Chongqing 40067 (China); Wang, Kai, E-mail: wangkai@hbu.edu.cn [Hebei Key Lab of Optic-electronic Information and Materials, The College of Physics Science and Technology, Hebei University, Baoding 071002 (China); Liu, Xiao-Bin [Department of Physics, Tianshui Normal University, Tianshui 741001 (China); Zeng, Jiao-Long [College of Science, National University of Defense Technology, Changsha, Hunan 410073 (China)

    2017-01-15

    Detailed calculations using the multi-configuration Dirac–Fock (MCDF) method are carried out for the lowest 64 fine-structure levels of the 3s{sup 2}3p{sup 2}, 3s{sup 2}3p3d, 3s3p{sup 3}, 3s3p{sup 2}3d, 3s{sup 2}3d{sup 2}, and 3p{sup 4} configurations in Si-like ions of La XLIII, Er LIV, Tm LV, and Yb LVI. Energies, oscillator strengths, wavelengths, line strengths, and radiative electric dipole transition rates are given for all ions. A parallel calculation using the many-body perturbation theory (MBPT) method is also carried out to assess the present energy levels accuracy. Comparisons are performed between these two sets of energy levels, as well as with other available results, showing that they are in good agreement with each other within 0.5%. These high accuracy results can be used to the modeling and the interpretation of astrophysical objects and fusion plasmas. - Highlights: • Energy levels and E1 transition rates of Si-like ions are presented. • Breit interaction and Quantum Electrodynamics effects are discussed. • Present results should be useful in the astrophysical application and plasma modeling.

  14. Oscillator strengths and transition probabilities from the Breit–Pauli R-matrix method: Ne IV

    Energy Technology Data Exchange (ETDEWEB)

    Nahar, Sultana N., E-mail: nahar@astronomy.ohio-state.edu

    2014-09-15

    The atomic parameters–oscillator strengths, line strengths, radiative decay rates (A), and lifetimes–for fine structure transitions of electric dipole (E1) type for the astrophysically abundant ion Ne IV are presented. The results include 868 fine structure levels with n≤ 10, l≤ 9, and 1/2≤J≤ 19/2 of even and odd parities, and the corresponding 83,767 E1 transitions. The calculations were carried out using the relativistic Breit–Pauli R-matrix method in the close coupling approximation. The transitions have been identified spectroscopically using an algorithm based on quantum defect analysis and other criteria. The calculated energies agree with the 103 observed and identified energies to within 3% or better for most of the levels. Some larger differences are also noted. The A-values show good to fair agreement with the very limited number of available transitions in the table compiled by NIST, but show very good agreement with the latest published multi-configuration Hartree–Fock calculations. The present transitions should be useful for diagnostics as well as for precise and complete spectral modeling in the soft X-ray to infra-red regions of astrophysical and laboratory plasmas. -- Highlights: •The first application of BPRM method for accurate E1 transitions in Ne IV is reported. •Amount of atomic data (n going up to 10) is complete for most practical applications. •The calculated energies are in very good agreement with most observed levels. •Very good agreement of A-values and lifetimes with other relativistic calculations. •The results should provide precise nebular abundances, chemical evolution etc.

  15. Cooperative effect of random and time-periodic coupling strength on synchronization transitions in one-way coupled neural system: mean field approach.

    Science.gov (United States)

    Jiancheng, Shi; Min, Luo; Chusheng, Huang

    2017-08-01

    The cooperative effect of random coupling strength and time-periodic coupling strengh on synchronization transitions in one-way coupled neural system has been investigated by mean field approach. Results show that cooperative coupling strength (CCS) plays an active role for the enhancement of synchronization transitions. There exist an optimal frequency of CCS which makes the system display the best CCS-induced synchronization transitions, a critical frequency of CCS which can not further affect the CCS-induced synchronization transitions, and a critical amplitude of CCS which can not occur the CCS-induced synchronization transitions. Meanwhile, noise intensity plays a negative role for the CCS-induced synchronization transitions. Furthermore, it is found that the novel CCS amplitude-induced synchronization transitions and CCS frequency-induced synchronization transitions are found.

  16. Application of the oscillator strength of 'hypersensitive' transitions to the investigation of complex equilibria of lanthanide ions

    International Nuclear Information System (INIS)

    Bukietynska, K.; Mondry, A.; Osmeda, E.

    1981-01-01

    Stability constants and thermodynamic parameters of Nd 3+ , Ho 3+ and Er 3+ complexes with acetates, propionates, glycolates, lactates and α-hydroxyisobutyrates were determined by a spectroscopic method based upon the measurements of the variation of oscillator strengths of 'hypersensitive' 4f-4f-transitions. The sets of βsub (n) values at 21 0 C are in a good agreement with those found potentiometrically. The stability constants of the complexes evaluated at 5 different temperatures were used for the calculation of ΔG, ΔH, ΔS values. The evaluated thermodynamic parameters are in a satisfactory agreement with those found calorimetrically. The thermodynamic parameters calculated from two independent 'hypersensitive' transitions of the Er 3+ ion are also consistent. (author)

  17. Electron impact collision strengths and transition rates for extreme ultraviolet emission from Xe10+

    International Nuclear Information System (INIS)

    Shen Yunfeng; Gao Cheng; Zeng Jiaolong

    2009-01-01

    The energy levels, oscillator strengths, and electron impact collision strengths are calculated for the Xe 10+ ion using the configuration interaction scheme implemented by the Flexible Atomic Code. These data pertain to the 3917 levels belonging to the following configurations: 4s 2 4p 6 4d 8 , 4s 2 4p 6 4d 7 4f, 4s 2 4p 6 4d 7 5l (l = s, p, d, or f), 4s 2 4p 5 4d 9 , 4s 2 4p 5 4d 8 4f, 4s 2 4p 5 4d 8 5l, 4s 2 4p 6 4d 6 5s5p, 4s 2 4p 6 4d 6 5p5d. Configuration interactions among these configurations are included in the calculation. Collision strengths are obtained at 10 scattered electron energies (1-1000 eV) and are tabulated here at five representative energies of 10, 50, 100, 500, and 1000 eV. Effective collision strengths are obtained by assuming a Maxwellian electron velocity distribution at 10 temperatures ranging from 10 to 100 eV, and are tabulated at five representative temperatures of 10, 30, 50, 70 and 100 eV in this work. The whole data set should be useful for research involving extreme ultraviolet emission from Xe 10+

  18. Relativistic model-potential oscillator strengths and transition probabilities for 4fsup(n)6s-4fsup(n)6p transitions in Eu(II), Tb(II), and Ho(II) in J1j coupling

    International Nuclear Information System (INIS)

    Migdalek, J.

    1984-01-01

    The lowest 4fsup(n)6s-4fsup(n)6p transitions are studied for the Eu(II) (n=7), Tb(II) (n=9), and Ho(II) (n=11) spectra, where the J 1 J coupling is an acceptable approximation. The relativistic radial integrals, required to evaluate the oscillator strengths and transition probabilities, are calculated with the model-potential method, which includes also core-polarization effects. The similarities observed in oscillator strengths for transitions with given ΔJ but different J values are discussed and explained. The computed oscillator strengths are compared with those obtained with the Coulomb approximation and it is found that the latter are only 11-12% lower. The core polarization influence on oscillator strengths is also investigated and the 19-21% decrease in oscillator strengths due to this effect is predicted. This result may, however, be overestimated because of some deficiencies in our procedure. (author)

  19. Strength, ductility, and ductile-brittle transition temperature for MFR [magnetic fusion reactor] candidate vanadium alloys

    International Nuclear Information System (INIS)

    Loomis, B.A.; Lee, R.H.; Smith, D.L.; Peterson, J.R.

    1987-09-01

    The dependence of the yield strength, tensile strength, elongation, and reduction in area on temperature for the V-15Ti-7.5Cr, V-20Ti, V-15Cr-5Ti, V-12Cr-5Ti, V-10Cr-5Ti, and V-3Ti-1Si alloys was determined from tensile tests at temperatures ranging from 25 to 700 0 C. The strength of the alloys increased with an increase of the combined Cr and Ti concentration. The total elongation for the alloys ranged between 20% and 38%. The reduction in area ranged from 30% to 90%. The DBTT, which was determined from the temperature dependence of the reduction in area, was less than 25 0 C for the V-15Ti-7.5Cr, V-20Ti, and V-3Ti-1Si alloys. The DBTT for the V-10Cr-5Ti, V-12Cr-5Ti, and V-15Cr-5Ti alloys was also less than 25 0 C if these alloys were annealed to reduce the hydrogen concentration prior to the tensile test. If these latter alloys were not annealed prior to the tensile test, the DBTT ranged from 40 0 C to 90 0 C and the DBTT increased with an increase of the Cr concentration. A Cr/Ti concentration ratio of 0 to 0.5 in these alloys was found to cause the alloys to be less susceptible to hydrogen embrittlement. 14 refs., 4 figs., 3 tabs

  20. Strength, ductility, and ductile-brittle transition temperature for MFR candidate vanadium alloys

    International Nuclear Information System (INIS)

    Loomis, B.A.; Lee, R.H.; Smith, D.L.

    1988-01-01

    The dependence of the yield strength, tensile strength, elongation, and reduction in area on temperature for the V-15Ti-7.5Cr, V-20Ti, V-15Cr-5Ti, V-12Cr-5Ti, V-10Cr-5Ti, and V-3Ti-1Si alloys was determined from tensile tests at temperatures ranging from 25 to 700 0 C. The strength of the alloys increased with an increase of the combined Cr and Ti concentration. The total elongation for the alloys ranged between 20 and 38%. The reduction in area ranged from 30 to 90%. The DBTT, which was determined from the temperature dependence of the reduction in area, was less than 25 0 C for the V-15Ti-7.5Cr, V-20Ti, and V-3Ti-1Si alloys. The DBTT for the V-10Cr-5Ti, V-12Cr-5Ti, and V-15Cr-5Ti alloys was also less than 25 0 C if these alloys were annealed to reduce the hydrogen concentration prior to the tensile test. If these latter alloys were not annealed prior to the tensile test, the DBTT ranged from 40 to 90 0 C and the DBTT increased with an increase of the Cr concentration. A Cr/Ti concentration ratio of 0-0.5 in these alloys was found to cause the alloys to be less susceptible to hydrogen embrittlement. (orig.)

  1. 0(gs)+ -->2(1)+ transition strengths in 106Sn and 108Sn.

    Science.gov (United States)

    Ekström, A; Cederkäll, J; Fahlander, C; Hjorth-Jensen, M; Ames, F; Butler, P A; Davinson, T; Eberth, J; Fincke, F; Görgen, A; Górska, M; Habs, D; Hurst, A M; Huyse, M; Ivanov, O; Iwanicki, J; Kester, O; Köster, U; Marsh, B A; Mierzejewski, J; Reiter, P; Scheit, H; Schwalm, D; Siem, S; Sletten, G; Stefanescu, I; Tveten, G M; Van de Walle, J; Van Duppen, P; Voulot, D; Warr, N; Weisshaar, D; Wenander, F; Zielińska, M

    2008-07-04

    The reduced transition probabilities, B(E2; 0(gs)+ -->2(1)+), have been measured in the radioactive isotopes (108,106)Sn using subbarrier Coulomb excitation at the REX-ISOLDE facility at CERN. Deexcitation gamma rays were detected by the highly segmented MINIBALL Ge-detector array. The results, B(E2;0(gs)+ -->2(1)+)=0.222(19)e2b2 for 108Sn and B(E2; 0(gs)+-->2(1)+)=0.195(39)e2b2 for 106Sn were determined relative to a stable 58Ni target. The resulting B(E2) values are approximately 30% larger than shell-model predictions and deviate from the generalized seniority model. This experimental result may point towards a weakening of the N=Z=50 shell closure.

  2. Atomistic simulation of ideal shear strength, point defects, and screw dislocations in bcc transition metals: Mo as a prototype

    International Nuclear Information System (INIS)

    Xu, W.; Moriarty, J.A.

    1996-01-01

    Using multi-ion interatomic potentials derived from first-principles generalized pseudopotential theory, we have studied ideal shear strength, point defects, and screw dislocations in the prototype bcc transition metal molybdenum (Mo). Many-body angular forces, which are important to the structural and mechanical properties of such central transition metals with partially filled d bands, are accounted for in the present theory through explicit three- and four-ion potentials. For the ideal shear strength of Mo, our computed results agree well with those predicted by full electronic-structure calculations. For point defects in Mo, our calculated vacancy-formation and activation energies are in excellent agreement with experimental results. The energetics of six self-interstitial configurations have also been investigated. The left-angle 110 right-angle split dumbbell interstitial is found to have the lowest formation energy, in agreement with the configuration found by x-ray diffuse scattering measurements. In ascending order, the sequence of energetically stable interstitials is predicted to be left-angle 110 right-angle split dumbbell, crowdion, left-angle 111 right-angle split dumbbell, tetrahedral site, left-angle 001 right-angle split dumbbell, and octahedral site. In addition, the migration paths for the left-angle 110 right-angle dumbbell self-interstitial have been studied. The migration energies are found to be 3 endash 15 times higher than previous theoretical estimates obtained using simple radial-force Finnis-Sinclair potentials. Finally, the atomic structure and energetics of left-angle 111 right-angle screw dislocations in Mo have been investigated. We have found that the so-called open-quote open-quote easy close-quote close-quote core configuration has a lower formation energy than the open-quote open-quote hard close-quote close-quote one, consistent with previous theoretical studies. (Abstract Truncated)

  3. Ultrasonic inspection of the strength member weld of transit and pioneer heat sources

    International Nuclear Information System (INIS)

    Dudley, W.A.

    1975-01-01

    A nondestructive technique was developed which allows ultrasonic inspection of the closure weld for the strength member component in plutonium-238 radioisotopic heat sources. The advantage of the ultrasonic approach, over that of the more commonly used radiographic one, is the recognized superiority of ultrasonic testing for identifying lack-of-weld penetration (LOP) when accompanied by incomplete diffusion bonding. The ultrasonic technique, a transverse mode scan of the weld for detection of LOP, is primarily accomplished by use of a holding fixture which permits the vented heat source to be immersed into an inspection tank. The mechanical portion of the scanning system is a lathe modified with an inspection tank and a manipulator. This scanning system has been used in the past to inspect SNAP-27 heat sources. The analyzer-transducer combination used in the inspection is capable of detecting a channel type flaw with a side wall depth of 0.076 mm (0.003 in.) in a weld standard. (U.S.)

  4. Absolute E3 and M2 transition probabilities for the electromagnetic decay of the I{sup {pi}}=K{sup {pi}}=8{sup -} isomeric state in {sup 132}Ce

    Energy Technology Data Exchange (ETDEWEB)

    Perkowski, J.; Andrzejewski, J.; Krol, A. [University of Lodz, Faculty of Physics and Applied Informatics, Lodz (Poland); Srebrny, J.; Kownacki, J.; Zielinska, M. [University of Warsaw, Heavy Ion Laboratory, Warsaw (Poland); Bruce, A.M. [University of Brighton, School of Environment and Technology, Brighton (United Kingdom); Droste, C.; Grodner, E.; Morek, T. [University of Warsaw, Nuclear Physics Division, IEP, Warsaw (Poland); Kisielinski, M. [University of Warsaw, Heavy Ion Laboratory, Warsaw (Poland); The Andrzej Soltan Institute for Nuclear Studies, Warsaw (Poland); Korman, A. [The Andrzej Soltan Institute for Nuclear Studies, Warsaw (Poland); Kowalczyk, M.; Mierzejewski, J. [University of Warsaw, Heavy Ion Laboratory, Warsaw (Poland); University of Warsaw, Nuclear Physics Division, IEP, Warsaw (Poland); Marganiec, J. [University of Lodz, Faculty of Physics and Applied Informatics, Lodz (Poland); Gesellschaft fuer Schwerionenforschung (GSI), Reactions and Nuclear Astrophysics Division, Darmstadt (Germany); Sobczak, K. [University of Lodz, Faculty of Physics and Applied Informatics, Lodz (Poland); Institute of Physics Polish Academy of Sciences, Warsaw (Poland); Trzaska, W.H. [University of Jyvaeskylae, Department of Physics, Survontie 9, P.O. Box 35, Jyvaeskylae (Finland); Helsinki Institute of Physics, Survontie 9, P.O. Box 35, Helsinki (Finland)

    2009-12-15

    The decay of the I{sup {pi}}=K{sup {pi}}=8{sup -} isomeric state at 2340keV in {sup 132}Ce has been investigated in the {sup 120}Sn({sup 16}O,4n){sup 132}Ce reaction. The measurements were carried out in e-{gamma} and {gamma}-{gamma} coincidence modes using an electron spectrometer coupled to the OSIRIS II gamma-ray array at the Heavy Ion Laboratory of the University of Warsaw. Experimentally obtained internal conversion coefficients for the 8{sup -}{yields}6{sup +} and 8{sup -}{yields}5{sup +} transitions allowed the multipolarities, mixing ratios, reduced transition probabilities and hindrance factors to be determined. (orig.)

  5. ScienceToGo.org: The Strengths and Weaknesses of Communicating Climate Change through Mass Transit Advertising Spaces

    Science.gov (United States)

    Lustick, D. S.; Lohmeier, J.; Chen, R. F.; Wilson, R.; Rabkin, D.; Thompson, S. R.

    2016-02-01

    Engaging urban populations with climate change science is a difficult challenge since cities can seem so removed from the `natural environment.' However, mass transit provides an inherent means of communicating environmental messages with a cross section of the urban population. The Out of Home Media (OHM) spaces found on platforms and inside train cars provide a potentially effective means of bringing informal science learning opportunities directly to an underserved STEM audience. Our team felt that any messaging curriculum for a coastal urban subway system must complement the scary reality of the impacts of a changing climate (i.e. rising sea levels) with current examples of how the city is preparing for a more sustainable future. Urban areas such as Boston must develop adaptation and mitigation strategies that will help them not only survive, but thrive in a changing environment. In 2013-14, ScienceToGo.org ran a series of 12 engaging posters and placards staring `Ozzie the Ostrich' on the Massachusetts Bay Transit Authority's Red and Orange subway lines targeting an audience of more than 400,000 riders per day. The 12 month curriculum was divided into three phases: reality, relevance, and hope. During the presentation, we will present the results of our quasi-experimental research which identifies, quantifies, and explains the observed impacts of the campaign on adult riders. The strengths and weaknesses of the communication strategy will be discussed. Finally, we will conclude with some recommendations for how this work could improve and inform other urban informal science learning initiatives.

  6. Time-resolved Fourier-transform infrared emission spectroscopy of Ag in the (1300-3600)-cm(-1) region: Transitions involving f and g states and oscillator strengths

    Czech Academy of Sciences Publication Activity Database

    Civiš, Svatopluk; Matulková, Irena; Cihelka, Jaroslav; Kubelík, Petr

    2010-01-01

    Roč. 82, č. 2 (2010), 022502 ISSN 1050-2947 R&D Projects: GA AV ČR IAA400400705; GA AV ČR KAN100500652 Institutional research plan: CEZ:AV0Z40400503 Keywords : spectroscopy * transitions * oscillator strengths Subject RIV: CF - Physical ; The oretical Chemistry Impact factor: 2.861, year: 2010

  7. Atomic data from the IRON Project. XXXII. On the accuracy of the effective collision strength for the electron impact excitation of the quadrupole transition in AR III

    Science.gov (United States)

    Galavís, M. E.; Mendoza, C.; Zeippen, C. J.

    1998-12-01

    Since te[Burgess et al. (1997)]{bur97} have recently questioned the accuracy of the effective collision strength calculated in the IRON Project for the electron impact excitation of the 3ssp23p sp4 \\ sp1 D -sp1 S quadrupole transition in Ar iii, an extended R-matrix calculation has been performed for this transition. The original 24-state target model was maintained, but the energy regime was increased to 100 Ryd. It is shown that in order to ensure convergence of the partial wave expansion at such energies, it is necessary to take into account partial collision strengths up to L=30 and to ``top-up'' with a geometric series procedure. By comparing effective collision strengths, it is found that the differences from the original calculation are not greater than 25% around the upper end of the common temperature range and that they are much smaller than 20% over most of it. This is consistent with the accuracy rating (20%) previously assigned to transitions in this low ionisation system. Also the present high-temperature limit agrees fairly well (15%) with the Coulomb-Born limit estimated by Burgess et al., thus confirming our previous accuracy rating. It appears that Burgess et al., in their data assessment, have overextended the low-energy behaviour of our reduced effective collision strength to obtain an extrapolated high-temperature limit that appeared to be in error by a factor of 2.

  8. The calculation of oscillator strengths for the 5s21S0→5s5p1,3P1 transitions in Cd-like ions

    International Nuclear Information System (INIS)

    Li Guangyuan

    1998-01-01

    The screened hydrogenic model is employed to calculate the oscillator strength of the 5s 2 1 S 0 -5s5p 1 P 1 resonance transition in Cd-like ions (Z = 48 -74). The expression for the oscillator strength of the 5s 2 1 S 0 -5s5p 3 P1 is given, with the introduction of the correctional coefficient K and the mixing angle in jj-coupling. The results are compared with that of other authors, and some discussions are also given

  9. MgH Rydberg series: Transition energies from electron propagator theory and oscillator strengths from the molecular quantum defect orbital method

    Science.gov (United States)

    Corzo, H. H.; Velasco, A. M.; Lavín, C.; Ortiz, J. V.

    2018-02-01

    Vertical excitation energies belonging to several Rydberg series of MgH have been inferred from 3+ electron-propagator calculations of the electron affinities of MgH+ and are in close agreement with experiment. Many electronically excited states with n > 3 are reported for the first time and new insight is given on the assignment of several Rydberg series. Valence and Rydberg excited states of MgH are distinguished respectively by high and low pole strengths corresponding to Dyson orbitals of electron attachment to the cation. By applying the Molecular Quantum Defect Orbital method, oscillator strengths for electronic transitions involving Rydberg states also have been determined.

  10. Method to increase the transition temperature and for the critical magnetic field strength of the known intermetallic compounds of vanadium or niobium

    International Nuclear Information System (INIS)

    Winter, H.

    1977-01-01

    The invention deals with a method to raise the transition temperature and critical magnetic field strength of superconducting, intermetallic compounds of vanadium and niobium. For example, a niobium alloy with 4 wt.% Al in melted in vacuum electric arc and formed into a sheet of about 1 mm thick. Strips of this sheet are electrically heated up to 1,900 0 C for one hour in a high-vacuum oven. The strips are then annealed in evacuated quartz ampoules for 120 hours at 800 0 C. These strips have a transition temperature of 24 K and a critical magnetic field strength of 600 kg; the critical current density was 5 x 10 4 A/cm 2 . (HPOE) [de

  11. The unusual strength of the 5.14→1.27MeV, 2-→2+ transition in 22Ne

    International Nuclear Information System (INIS)

    Merdinger, J.C.; Bozek, E.; Gehringer, C.; Stachura, Z.

    1975-01-01

    The lifetime of the 5.14MeV excited state of 22 Ne was investigated by use of the electronic timing, recoil distance and Doppler shift attenuation techniques. A mean life tau=1.2+-0.3ps was obtained, corresponding to a transition strength of 9.8x10 -6 W.u. for the E1 decay of this state [fr

  12. Strength and rupture-life transitions caused by secondary carbide precipitation in HT-9 during high-temperature low-rate mechanical testing

    International Nuclear Information System (INIS)

    DiMelfi, R.J.; Gruber, E.E.; Kramer, J.M.; Hughes, T.H.

    1992-01-01

    The martensitic-ferritic alloy HT-9 is slated for long-term use as a fuel-cladding material in the Integral Fast Reactor. Analysis of published high-temperature mechanical property data suggests that secondary carbide precipitation would occur during service life causing substantial strengthening of the as-heat-treated material. Aspects of the kinetics of this precipitation process are extracted from calculations of the back stress necessary to produce the observed strengthening effect under various creep loading conditions. The resulting Arrhenius factor is shown to agree quantitatively with shifts to higher strength of crept material in reference to the intrinsic strength of HT-9. The results of very low constant strain-rate high-temperature tensile tests on as-heat-treated HT-9 that focus on the transition in strength with precipitation will be presented and related to rupture-life

  13. Known for My Strengths: Positive Traits of Transition-Age Youth With Intellectual Disability and/or Autism

    Science.gov (United States)

    Carter, Erik W.; Boehm, Thomas L.; Biggs, Elizabeth E.; Annandale, Naomi H.; Taylor, Courtney E.; Loock, Aimee K.; Liu, Rosemary Y.

    2015-01-01

    Can young people with intellectual and developmental disabilities be known for their strengths? This mixed-method study explored the strengths of 427 youth and young adults with intellectual disability and/or autism (ages 13-21) from the vantage point of their parents. Using the Assessment Scale for Positive Character Traits-Developmental…

  14. E3Net: a system for exploring E3-mediated regulatory networks of cellular functions.

    Science.gov (United States)

    Han, Youngwoong; Lee, Hodong; Park, Jong C; Yi, Gwan-Su

    2012-04-01

    Ubiquitin-protein ligase (E3) is a key enzyme targeting specific substrates in diverse cellular processes for ubiquitination and degradation. The existing findings of substrate specificity of E3 are, however, scattered over a number of resources, making it difficult to study them together with an integrative view. Here we present E3Net, a web-based system that provides a comprehensive collection of available E3-substrate specificities and a systematic framework for the analysis of E3-mediated regulatory networks of diverse cellular functions. Currently, E3Net contains 2201 E3s and 4896 substrates in 427 organisms and 1671 E3-substrate specific relations between 493 E3s and 1277 substrates in 42 organisms, extracted mainly from MEDLINE abstracts and UniProt comments with an automatic text mining method and additional manual inspection and partly from high throughput experiment data and public ubiquitination databases. The significant functions and pathways of the extracted E3-specific substrate groups were identified from a functional enrichment analysis with 12 functional category resources for molecular functions, protein families, protein complexes, pathways, cellular processes, cellular localization, and diseases. E3Net includes interactive analysis and navigation tools that make it possible to build an integrative view of E3-substrate networks and their correlated functions with graphical illustrations and summarized descriptions. As a result, E3Net provides a comprehensive resource of E3s, substrates, and their functional implications summarized from the regulatory network structures of E3-specific substrate groups and their correlated functions. This resource will facilitate further in-depth investigation of ubiquitination-dependent regulatory mechanisms. E3Net is freely available online at http://pnet.kaist.ac.kr/e3net.

  15. Excitation strengths and transition radii differences of one-phonon quadrupole excitations from electron scattering on {sup 92,94}Zr and {sup 94}Mo

    Energy Technology Data Exchange (ETDEWEB)

    Sheikh Obeid, Abdulrahman

    2014-11-01

    In the framework of this thesis electron scattering experiments on low-energy excitations of {sup 92}Zr and {sup 94}Zr were performed at the S-DALINAC in a momentum transfer range q=0.3-0.6 fm{sup -1}. The nature of one-phonon symmetric and mixed-symmetric 2{sup +} and 3{sup -} states of {sup 92}Zr was investigated by comparison with predictions of the quasi-particle phonon model (QPM). Theoretical (e,e') cross sections have been calculated within the distorted wave Born approximation (DWBA) to account for Coulomb distortion effects. The reduced strengths of the one-quadrupole phonon states and the one-octupole phonon state have been extracted. The similarity of the momentum-transfer dependence of the form factors between the 2{sup +} states supports the one-phonon nature of the 2{sup +}{sub 2} state of {sup 92}Zr. A new method based on the Plane Wave Born Approximation (PWBA) for a model-independent determination of the ratio of the E2 transition strengths of fully symmetric (FSS) and mixed-symmetry (MSS) one-phonon excitations of heavy vibrational nuclei is introduced. Due to the sensitivity of electron scattering to charge distributions, the charge transition-radii difference can be determined. The basic assumptions (independence from the ratio of Coulomb corrections and from absolute values of transition radii) are tested within the Tassie model, which makes no specific assumptions about the structure of the states other than collectivity. It is shown that a PWBA analysis of the form factors, which usually fails for heavy nuclei, can nevertheless be applied in a relative analysis. This is a new promising approach to determine the ground state transition strength of the 2{sup +} MSS of vibrational nuclei with a precision limited only by the experimental information about the B(E2;2{sup +}{sub 1}→0{sup +}{sub 1}) strength. The PWBA approach furthermore provides information about differences of the proton transition radii of the respective states

  16. TRANSIT

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. TRANSIT. SYSTEM: DETERMINE 2D-POSITION GLOBALLY BUT INTERMITTENT (POST-FACTO). IMPROVED ACCURACY. PRINCIPLE: POLAR SATELLITES WITH INNOVATIONS OF: GRAVITY-GRADIENT ATTITUDE CONTROL; DRAG COMPENSATION. WORKS ...

  17. E3 Travel & Mission Support System

    Data.gov (United States)

    US Agency for International Development — ETRAMS is a travel data collection system developed by the CKM team in E3 that collects information on both the basic details of an employee's trips (destination,...

  18. E3 Financing How-to Guide

    Science.gov (United States)

    The Financing How-to-Guide is intended to help manufacturers and their communities navigate financing and investment opportunities. While this guide provides an overview, there is no one-way to pay for E3 activities or attract investment.

  19. E3: Economy, Energy and Environment

    Science.gov (United States)

    E3 is a technical assistance framework helping communities, manufacturers, and manufacturing supply chains adapt and thrive in today's green economy. Find information on pollution prevention, sustainable business practices, and energy efficiency.

  20. E3: Extreme Energy Event monitoring

    CERN Document Server

    CERN. Geneva

    2015-01-01

    World peace through CERN technology: Use of explosives especially in urban areas is the defining phenomenon of the last and current century. E3 aims to reduce such excesses of violence by collecting scientific hard evidence.

  1. Quadrupole and monopole generalized oscillator strength for 2p-3p, 2p-4p transition of neon atomic in the velocity formulation

    International Nuclear Information System (INIS)

    Gomis, L; Diedhiou, I; Tall, M S; Diallo, S; Diatta, C S; Niassy, B

    2007-01-01

    The quadrupole and monopole generalized oscillator strengths (GOS) as a function of momentum transfer are calculated for the 2p-3p and 2p-4p transitions of the neon atom using the analytical Hartree-Fock (HF) wavefunctions for the ground-state and the wavefunctions for the excited states which are obtained numerically from the modified HF Slater equation. Calculations are carried out by using the HF method and random phase approximation with exchange in the velocity formulation. The positions and the number of the extrema in the GOS have received particular attention in the evaluation. Our calculated monopole GOS of 2p-3p transition in velocity form reveals one maximum located between the experimental and theoretical results of other authors. The disagreement between our first maximum of the quadrupole GOS 2p-3p transition with the experimental and other theoretical ones is unimportant. The extrema of the monopole and quadrupole GOS of 2p-4p transition are given in this paper. The results of velocity form study also show that the electron correlation effects are important around the maxima and are found to influence the positions of the extrema insignificantly

  2. The strength of the M2 transition from the 7-/2 hole state in 43K

    International Nuclear Information System (INIS)

    Poletti, A.R.; Southon, J.R.

    1977-01-01

    The mean life of the 738 keV level of 43 K has been measured by direct electronic timing as tausub(m) = 265 +- 15 ns. The reaction 40 Ar(α,pγ) 43 K at 10.4 MeV was used to excite the level. A comparison is made with another recent measurement while the deduced M2 strength is compared with those in other potassium isotopes. (author)

  3. Effect of cooling rate during solidification of Sn-9Zn lead-free solder alloy on its microstructure, tensile strength and ductile-brittle transition temperature

    Energy Technology Data Exchange (ETDEWEB)

    Prabhu, K.N., E-mail: prabhukn_2002@yahoo.co.in [Department of Metallurgical and Materials Engineering, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025 (India); Deshapande, Parashuram; Satyanarayan [Department of Metallurgical and Materials Engineering, National Institute of Technology Karnataka, Surathkal, Mangalore 575 025 (India)

    2012-01-30

    Highlights: Black-Right-Pointing-Pointer Effect of cooling rate on tensile and impact properties of Sn-9Zn alloy was assessed. Black-Right-Pointing-Pointer Both DBTT and UTS of the solder alloy increased with increase in cooling rate. Black-Right-Pointing-Pointer An optimum cooling rate during solidification would minimize DBTT and maximize UTS. - Abstract: Solidification rate is an important variable during processing of materials, including soldering, involving solidification. The rate of solidification controls the metallurgical microstructure at the solder joint and hence the mechanical properties. A high tensile strength and a lower ductile-brittle transition temperature are necessary for reliability of solder joints in electronic circuits. Hence in the present work, the effect of cooling rate during solidification on microstructure, impact and tensile properties of Sn-9Zn lead-free solder alloy was investigated. Four different cooling media (copper and stainless steel moulds, air and furnace cooling) were used for solidification to achieve different cooling rates. Solder alloy solidified in copper mould exhibited higher cooling rate as compared to other cooling media. The microstructure is refined as the cooling rate was increased from 0.03 to 25 Degree-Sign C/s. With increase in cooling rate it was observed that the size of Zn flakes became finer and distributed uniformly throughout the matrix. Ductile-to-brittle transition temperature (DBTT) of the solder alloy increased with increase in cooling rate. Fractured surfaces of impact test specimens showed cleavage like appearance and river like pattern at very low temperatures and dimple like appearance at higher temperatures. The tensile strength of the solder alloy solidified in Cu and stainless moulds were higher as compared to air and furnace cooled samples. It is therefore suggested that the cooling rate during solidification of the solder alloy should be optimum to maximize the strength and minimize the

  4. Effect of cooling rate during solidification of Sn–9Zn lead-free solder alloy on its microstructure, tensile strength and ductile–brittle transition temperature

    International Nuclear Information System (INIS)

    Prabhu, K.N.; Deshapande, Parashuram; Satyanarayan

    2012-01-01

    Highlights: ► Effect of cooling rate on tensile and impact properties of Sn–9Zn alloy was assessed. ► Both DBTT and UTS of the solder alloy increased with increase in cooling rate. ► An optimum cooling rate during solidification would minimize DBTT and maximize UTS. - Abstract: Solidification rate is an important variable during processing of materials, including soldering, involving solidification. The rate of solidification controls the metallurgical microstructure at the solder joint and hence the mechanical properties. A high tensile strength and a lower ductile–brittle transition temperature are necessary for reliability of solder joints in electronic circuits. Hence in the present work, the effect of cooling rate during solidification on microstructure, impact and tensile properties of Sn–9Zn lead-free solder alloy was investigated. Four different cooling media (copper and stainless steel moulds, air and furnace cooling) were used for solidification to achieve different cooling rates. Solder alloy solidified in copper mould exhibited higher cooling rate as compared to other cooling media. The microstructure is refined as the cooling rate was increased from 0.03 to 25 °C/s. With increase in cooling rate it was observed that the size of Zn flakes became finer and distributed uniformly throughout the matrix. Ductile-to-brittle transition temperature (DBTT) of the solder alloy increased with increase in cooling rate. Fractured surfaces of impact test specimens showed cleavage like appearance and river like pattern at very low temperatures and dimple like appearance at higher temperatures. The tensile strength of the solder alloy solidified in Cu and stainless moulds were higher as compared to air and furnace cooled samples. It is therefore suggested that the cooling rate during solidification of the solder alloy should be optimum to maximize the strength and minimize the DBTT.

  5. Strength problems and ordering of nonstoichiometric monocarbides and mononitrides of subgroup 4a i 5a transition metals

    International Nuclear Information System (INIS)

    Manukhin, A.V.; Lopatin, P.B.

    1995-01-01

    Consideration is given to graphical concentration dependences of flexural strength limit of TiC x and VC x monocarbides, ZrN x mononitride and to the relationship between these dependences and phenomena of nonmetallic vacancy ordering in mentioned compounds. The assumption about existence of the second ordered structure in TiC x titanium monocarbide and ordered structure in ZrN x zirconium mononitride (0.78...0.8 < x < 0.9...0.95) was supported. 15 refs.; 4 figs

  6. Benchmarking transition energies and emission strengths for X-ray astrophysics with measurements at the Livermore EBITs

    Energy Technology Data Exchange (ETDEWEB)

    Hell, Natalie [Friedrich Alexander Univ., Erlangen (Germany)

    2017-03-15

    K-shell transitions in astrophysically abundant metals and L-shell transitions in Fe group elements show characteristic signatures in the soft X-ray spectrum in the energy range 0.1–10 keV. These signatures have great diagnostic value for plasma parameters such as electron and ion temperatures and densities, and can thus help understand the physics controlling the energetic processes in astrophysical sources. This diagnostic power increases with advances in spectral resolution and effective area of the employed X-ray observatories. However, to make optimal use of the diagnostic potential – whether through global spectral modeling or through diagnostics from local modeling of individual lines – the underlying atomic physics has to be complete and well known. With the next generation of soft X-ray observatories featuring micro-calorimeters such as the SXS on Astro- H/Hitomi and the X-IFU on Athena, broadband high-resolution spectroscopy with large effective area will become more commonly available in the next decade. With these spectrometers, the accuracy of the plasma parameters derived from spectral modeling will be limited by the uncertainty of the reference atomic data rather than by instrumental factors, as is sometimes already the case for the high-resolution grating observations with Chandra-HETG and XMM-Newton-RGS. To take full advantage of the measured spectra, assessment of the accuracy of and improvements to the available atomic reference data are therefore important. Dedicated measurements in the laboratory are essential to benchmark the theoretical calculations providing the bulk of the reference data used in astrophysics. Experiments at the Lawrence Livermore National Laboratory electron beam ion traps (EBIT-I and SuperEBIT) have a long history of providing this service. In this work, I present new measurements of transition energies and absolute electron impact excitation cross sections geared towards currently open atomic physics data needs.

  7. Evolution of E 2 transition strength in deformed hafnium isotopes from new measurements on 172Hf,174Hf, and 176Hf

    Science.gov (United States)

    Rudigier, M.; Nomura, K.; Dannhoff, M.; Gerst, R.-B.; Jolie, J.; Saed-Samii, N.; Stegemann, S.; Régis, J.-M.; Robledo, L. M.; Rodríguez-Guzmán, R.; Blazhev, A.; Fransen, Ch.; Warr, N.; Zell, K. O.

    2015-04-01

    Background: The available data for E 2 transition strengths in the region between neutron-deficient hafnium and platinum isotopes are far from complete. More and precise data are needed to enhance the picture of structure evolution in this region and to test state-of-the-art nuclear models. In a simple model, the maximum collectivity is expected at the middle of the major shell. However, for actual nuclei, particularly in heavy-mass regions, which should be highly complex, this picture may no longer be the case, and one should use a more realistic nuclear-structure model. We address this point by studying the spectroscopy of Hf as a representative case. Purpose: We remeasure the 21+ half-lives of 172,174,176Hf, for which there is some disagreement in the literature. The main goal is to measure, for the first time, the half-lives of higher-lying states of the rotational band. The new results are compared to a theoretical calculation for absolute transition strengths. Method: The half-lives were measured using γ -γ and conversion-electron-γ delayed coincidences with the fast timing method. For the determination of half-lives in the picosecond region, the generalized centroid difference method was applied. For the theoretical calculation of the spectroscopic properties, the interacting boson model is employed, whose Hamiltonian is determined based on microscopic energy-density functional calculations. Results: The measured 21+ half-lives disagree with results from earlier γ -γ fast timing measurements, but are in agreement with data from Coulomb excitation experiments and other methods. Half-lives of the 41+ and 61+ states were measured, as well as a lower limit for the 81+ states. Conclusions: This work shows the importance of a mass-dependent effective boson charge in the interacting boson model for the description of E 2 transition rates in chains of nuclei. It encourages further studies of the microscopic origin of this mass dependence. New experimental

  8. Q2 Dependence of Quadrupole Strength in the gamma*p-->Delta+(1232) --> p pi0 Transition

    International Nuclear Information System (INIS)

    Volker Burkert; Kyungseon Joo; Lee Smith; Ralph Minehart

    2002-01-01

    Models of baryon structure predict a small quadrupole deformation of the nucleon due to residual tensor forces between quarks or distortions from the pion cloud. Sensitivity to quark versus pion degrees of freedom occurs through the Q 2 dependence of the magnetic (M 1+ ), electric (E 1+ ), and scalar (S 1+ ) multipoles in the γ*p → Δ + (1232) → pπ 0 transition. New precision measurements of the ratios E 1+ /M 1+ and S 1+ /M 1+ are reported here over the range Q 2 = 0.4-1.8 GeV 2 . Results are best described by recent unitary models in which the pion cloud plays a dominant role

  9. Optical absorption of carbon nanotube diodes: Strength of the electronic transitions and sensitivity to the electric field polarization

    Science.gov (United States)

    Mencarelli, Davide; Pierantoni, Luca; Rozzi, Tullio

    2008-03-01

    Aim of this work is to model electrostatically doped carbon nanotubes (CNT), which have recently proved to perform as ideal PN diodes, also showing photovoltaic properties. The new model is able to predict the optical absorption of semiconducting CNT as function of size and chirality. We justify theoretically, for the first time, the experimentally observed capability of CNTs to detect and select not only a well defined set of frequencies, as resulting from their discrete band structure, but also the polarization of the incident radiation. The analysis develops from an approach proposed in a recent contribution. The periodic structure of CNTs is formally modeled as a photonic crystal, that is characterized by means of numerical simulators. Longitudinal and transverse components of the electric field are shown to excite distinct interband transitions between well defined energy levels. Equivalently, for a given energy of the incident radiation, absorption may show polarization ratios strongly exceeding unity.

  10. Generalized oscillator strength for the argon 3p6-3p5 4s transition: Correlation and exchange effects on the characteristic minimum

    International Nuclear Information System (INIS)

    Chen, Zhifan; Msezane, Alfred Z.; Amusia, M. Ya.

    1999-01-01

    We have investigated the generalized oscillator strength (GOS) for a transition of the type np→(n+1)s, where n is the principal quantum number of the outermost filled shell of the atomic ground state, using the random-phase approximation with exchange. We find that the influence of correlation and exchange effects on the position of the characteristic minimum in the GOS of Ar(n=3) is insignificant. Also, our first Born approximation predicts the position of the minimum accurately provided that accurate target wave functions are employed. Our results agree excellently with measurements and are expected to be applicable equally to the corresponding subshells of Ne(n=2), Kr(n=4), and Xe(n=5). (c) 1999 The American Physical Society

  11. Generalized oscillator strength for the argon 3p{sup 6}-3p{sup 5} 4s transition: Correlation and exchange effects on the characteristic minimum

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Zhifan [Center for Theoretical Studies of Physical Systems, and Department of Physics, Clark Atlanta University, Atlanta, Georgia 30314 (United States); Msezane, Alfred Z. [Center for Theoretical Studies of Physical Systems, and Department of Physics, Clark Atlanta University, Atlanta, Georgia 30314 (United States); Amusia, M. Ya. [Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, (Israel)

    1999-12-01

    We have investigated the generalized oscillator strength (GOS) for a transition of the type np{yields}(n+1)s, where n is the principal quantum number of the outermost filled shell of the atomic ground state, using the random-phase approximation with exchange. We find that the influence of correlation and exchange effects on the position of the characteristic minimum in the GOS of Ar(n=3) is insignificant. Also, our first Born approximation predicts the position of the minimum accurately provided that accurate target wave functions are employed. Our results agree excellently with measurements and are expected to be applicable equally to the corresponding subshells of Ne(n=2), Kr(n=4), and Xe(n=5). (c) 1999 The American Physical Society.

  12. Scaling laws in (e,3e) processes

    International Nuclear Information System (INIS)

    Gasaneo, G; Rodriguez, K V; Ancarani, L U; Cappello, C Dal; Charpentier, I

    2009-01-01

    We study the double ionization of helium-like ions by impact of electrons with high incident energy. Within the isoelectronic sequence, an approximate scaling law for (e,3e) differential cross sections is proposed and confirmed by calculations. The latter are performed using 14-parameters Hylleraas-like wave functions to represent the bound electrons in the initial channel, plane waves for the fast incoming and scattered electrons, and a continuum distorted wave approach for the two ejected electrons in the final channel.

  13. E3 Success Story - E3 Southwest Virginia: Economy, Energy and the Environment

    Science.gov (United States)

    E3 Southwest Virginia supports sustainable manufacturing in 17 counties in southwest Virginia. The MTC provides manufacturers with assessments of production processes to reduce their energy consumption and drive innovation.

  14. Compressive strength and interfacial transition zone of sugar cane bagasse ash concrete: A comparison to the established pozzolans

    Science.gov (United States)

    Hussein, Asma Abd Elhameed; Shafiq, Nasir; Nuruddin, Muhd Fadhil

    2015-05-01

    Agricultural and industrial by-products are commonly used in concrete production as cement replacement materials (CRMs) or as admixtures to enhance both fresh and hardened properties of concrete as well as to save the environment from the negative effects caused by their disposal. Sugar Cane Bagasse Ash (SCBA) is one of the promising CRMs, it is used as a partial replacement of cement for producing concrete; properties of such concrete depend on the chemical composition, fineness, and burning temperature of SCBA. Approximately 1500 Million tons of sugarcane are annually produced over all the world which leave about 40-45% bagasse after juice crushing for sugar industry giving an average annual production of about 600 Million tons of bagasse as a waste material. This paper presents some findings on the effect of SCBA on workability, compressive strength and microstructure of interfacial zone of concrete and its performance is compared to some of the established CRMs namely Densified Silica Fume, Fly Ash and Microwave Incinerated Rice Husk Ash.

  15. New technique for a simultaneous estimation of the level density and radiative strength functions of dipole transitions at E sub e sub x<=B sub n -0.5 MeV

    CERN Document Server

    Khitrov, V A

    2001-01-01

    The new, model-independent method to estimate simultaneously the level densities excited in the (n,gamma) reaction and the radiative strength functions of dipole transitions is developed. The method can be applied for any nucleus and reaction followed by cascade gamma-emission. It is just necessary to measure the intensities of two-step gamma-cascades depopulating one or several high-excited states and determine the quanta ordering in the main portion of the observed cascades. The method provides a sufficiently narrow interval of most probable densities of levels with given J suppi and radiative strength functions of dipole transitions populating them.

  16. Enhanced E3 Excitations in 144,146Ba and the Evolution of Octupole Collectivity

    Science.gov (United States)

    Bucher, B.; Zhu, S.; ANL, LLNL, LBNL, INL, UAM, Rochester, Maryland Collaboration

    2017-09-01

    Recent Coulomb excitation studies on 144,146Ba using the GRETINA-CHICO2 detection system with post-accelerated CARIBU beams have confirmed the existence of enhanced E3 transitions in these isotopes which are centered in a region that has long been predicted to exhibit stable octupole-deformed shapes. Furthermore, the widely-varying E1 strength observed between these isotopes is well-accounted for by models having octupole-deformed potentials, and the variation has been linked to increased occupancies of specific single-particle orbitals in the reflection-asymmetric potential. This talk will summarize the most recent experimental and theoretical results. In addition, data on octupole-related properties in the surrounding isotopes will be discussed in an attempt to better understand the origin and evolution of octupole collectivity in this mass region. This work is supported by the U.S. Department of Energy, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 (ANL), DE-AC02-05CH11231 (LBNL, GRETINA), DOE DE-AC52-07NA27344 (LLNL), DE-AC07-05ID14517 (INL), and MINECO (Spain).

  17. Enhancement of octupole strength in near spherical nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Robledo, L.M. [Universidad Autonoma de Madrid, Dep. Fisica Teorica, Facultad de Ciencias, Madrid (Spain)

    2016-09-15

    The validity of the rotational formula used to compute E1 and E3 transition strengths in even-even nuclei is analyzed within the Generator Coordinate Method framework based on mean field wave functions. It turns out that those nuclei with spherical or near spherical shapes the E1 and E3 strengths computed with this formula are strongly underestimated and a sound evaluation of them requires angular-momentum projected wave functions. Results for several isotopic chains with proton number equal to or near magic numbers are analyzed and compared with experimental data. The use of angular-momentum projected wave functions greatly improves the agreement with the scarce experimental data. (orig.)

  18. E3 Success Story - San Antonio E3 Case Study: UEMC “Now Hiring”

    Science.gov (United States)

    exas Manufacturing Assistance Center conducted an E3 assessment as part of the local Lean-Clean-Energy program in October of 2009. Overall, UEMC has reduced demand by approximately 30kw and reduced consumption by over 100,000 kwh/year.

  19. The Chang'e 3 Mission Overview

    Science.gov (United States)

    Li, Chunlai; Liu, Jianjun; Ren, Xin; Zuo, Wei; Tan, Xu; Wen, Weibin; Li, Han; Mu, Lingli; Su, Yan; Zhang, Hongbo; Yan, Jun; Ouyang, Ziyuan

    2015-07-01

    The Chang'e 3 (CE-3) mission was implemented as the first lander/rover mission of the Chinese Lunar Exploration Program (CLEP). After its successful launch at 01:30 local time on December 2, 2013, CE-3 was inserted into an eccentric polar lunar orbit on December 6, and landed to the east of a 430 m crater in northwestern Mare Imbrium (19.51°W, 44.12°N) at 21:11 on December 14, 2013. The Yutu rover separated from the lander at 04:35, December 15, and traversed for a total of 0.114 km. Acquisition of science data began during the descent of the lander and will continue for 12 months during the nominal mission. The CE-3 lander and rover each carry four science instruments. Instruments on the lander are: Landing Camera (LCAM), Terrain Camera (TCAM), Extreme Ultraviolet Camera (EUVC), and Moon-based Ultraviolet Telescope (MUVT). The four instruments on the rover are: Panoramic Camera (PCAM), VIS-NIR Imaging Spectrometer (VNIS), Active Particle induced X-ray Spectrometer (APXS), and Lunar Penetrating Radar (LPR). The science objectives of the CE-3 mission include: (1) investigation of the morphological features and geological structures of and near the landing area; (2) integrated in-situ analysis of mineral and chemical composition of and near the landing area; and (3) exploration of the terrestrial-lunar space environment and lunar-based astronomical observations. This paper describes the CE-3 objectives and measurements that address the science objectives outlined by the Comprehensive Demonstration Report of Phase II of CLEP. The CE-3 team has archived the initial science data, and we describe data accessibility by the science community.

  20. Generalized oscillator strength for the transition Aapprox. /sup 1/B/sup 2u/Xapprox. A/sub 1g/ in benzene at initial kinetic energies 400 eV and 500 eV

    Energy Technology Data Exchange (ETDEWEB)

    Klump, K N; Lassettre, E N

    1977-10-01

    Generalized oscillator strengths, f, for the transition A/sup 1/B/sub 2u/ reverse arrow X/sup 1/A/sub 1g/ in benzene, determined by electron impact methods, are reported as a function of the momentum change. At scattering angles down to 2.5/sup 0/ helium was used as the comparison gas. Determinations are also reported at theta = 0/sup 0/ using mercury as the comparison gas. The oscillator strength curve has both a minimum and a maximum due to the superposition of electric dipole and octupole transitions. The band envelope is studied and is shown to remain unchanged in shape but is shifted by h nu/sub 6/ approximately 0.065 eV with increasing angle due to the shift from electric dipole to octupole scattering.

  1. A Longitudinal Study into Indicators of Mental Health, Strengths and Difficulties Reported by Boarding Students as They Transition from Primary School to Secondary Boarding Schools in Perth, Western Australia

    Science.gov (United States)

    Mander, David J.; Lester, Leanne

    2017-01-01

    This study examined indicators of mental health, as well as strengths and difficulties, as reported by same-age boarding and non-boarding students spanning four time points over a 2-year period as they transitioned from primary to boarding school in Western Australia (i.e., at the end of Grade 7, beginning of Grade 8, end of Grade 8, and end of…

  2. Some nonunitary, indecomposable representations of the Euclidean algebra e(3)

    International Nuclear Information System (INIS)

    Douglas, Andrew; De Guise, Hubert

    2010-01-01

    The Euclidean group E(3) is the noncompact, semidirect product group E(3)≅R 3 x SO(3). It is the Lie group of orientation-preserving isometries of three-dimensional Euclidean space. The Euclidean algebra e(3) is the complexification of the Lie algebra of E(3). We construct three distinct families of finite-dimensional, nonunitary representations of e(3) and show that each representation is indecomposable. The representations of the first family are explicitly realized as subspaces of the polynomial ring F[X,Y,Z] with the action of e(3) given by differential operators. The other families are constructed via duals and tensor products of the representations within the first family. We describe subrepresentations, quotients and duals of these indecomposable representations.

  3. Weighted f-values, A-values, and line strengths for the E1 transitions among 3d6, 3d54s, and 3d54p levels of Fe III

    International Nuclear Information System (INIS)

    Deb, Narayan C.; Hibbert, Alan

    2009-01-01

    Weighted oscillator strengths, weighted radiative rates, and line strengths for all the E1 transitions between 285 fine-structure levels belonging to the 3d 6 , 3d 5 4s, and 3d 5 4p configurations of Fe III are presented, in ascending order of wavelength. Calculations have been undertaken using the general configuration interaction (CI) code CIV3. The large configuration set is constructed by allowing single and double replacements from any of 3d 6 , 3d 5 4s, 3d 5 4p, and 3d 5 4d configurations to nl orbitals with n≤5,l≤3 as well as 6p. Additional selective promotions from 3s and 3p subshells are also included in the CI expansions to incorporate the important correlation effects in the n=3 shell. Results of some strong transitions between levels of 3d 6 , 3d 5 4s, and 3d 5 4p configurations are also presented and compared with other available calculations. It is found that large disagreements occur in many transitions among the existing calculations

  4. On the strength of the U{sub A}(1) anomaly at the chiral phase transition in N{sub f}=2 QCD

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, Bastian B. [Institut für Theoretische Physik, Goethe-Universität,D-60438 Frankfurt am Main (Germany); Institut für theoretische Physik, Universität Regensburg,D-93040 Regensburg (Germany); Francis, Anthony [Department of Physics & Astronomy, York University,4700 Keele St, Toronto, ON M3J 1P3 (Canada); Meyer, Harvey B. [PRISMA Cluster of Excellence, Institut für Kernphysik and Helmholtz Institut Mainz,Johannes Gutenberg-Universität Mainz, D-55099 Mainz (Germany); Philipsen, Owe [Institut für Theoretische Physik, Goethe-Universität,D-60438 Frankfurt am Main (Germany); Robaina, Daniel; Wittig, Hartmut [PRISMA Cluster of Excellence, Institut für Kernphysik and Helmholtz Institut Mainz,Johannes Gutenberg-Universität Mainz, D-55099 Mainz (Germany)

    2016-12-30

    We study the thermal transition of QCD with two degenerate light flavours by lattice simulations using O(a)-improved Wilson quarks. Temperature scans are performed at a fixed value of N{sub t}=(aT){sup −1}=16, where a is the lattice spacing and T the temperature, at three fixed zero-temperature pion masses between 200 MeV and 540 MeV. In this range we find that the transition is consistent with a broad crossover. As a probe of the restoration of chiral symmetry, we study the static screening spectrum. We observe a degeneracy between the transverse isovector vector and axial-vector channels starting from the transition temperature. Particularly striking is the strong reduction of the splitting between isovector scalar and pseudoscalar screening masses around the chiral phase transition by at least a factor of three compared to its value at zero temperature. In fact, the splitting is consistent with zero within our uncertainties. This disfavours a chiral phase transition in the O(4) universality class.

  5. E3 Testing of Directed Energy Systems: A Challenging Future

    National Research Council Canada - National Science Library

    Brown, Lyndell R

    2009-01-01

    .... Compatibility testing and susceptibility to electromagnetic radiation is required. Standards, such as MIL-STD-464 and MIL-STD-237D, are being revised to include HPM levels and frequencies for E3 tests...

  6. E3: Economy - Energy - Environment; Supporting Manufacturing Leadership through Sustainability

    Data.gov (United States)

    U.S. Environmental Protection Agency — The E3 initiative is designed to help you thrive in a new business era focused on sustainability and, working together, to promote sustainable manufacturing and...

  7. E3 Success Story - Working Together: E3 Ohio and the Ohio By-Product Synergy Network

    Science.gov (United States)

    The Mid-Ohio Regional Planning Commission (MORPC) received funding to support the integration of the national E3 sustainability initiative with the Ohio By-Product Synergy (BPS) Network to create an efficient and replicable model for reducing GHGs.

  8. Effective inclusion of polarization effects in calculations of the oscillator strengths and transition energies in atoms and molecules using the equation-of-motion method

    International Nuclear Information System (INIS)

    Glushkov, A.V.; Kol'tsova, N.Yu.

    1994-01-01

    Equations of motion were solved by a modified method in a quasi-particle representation of the density functional taking into account the most important polarization effects, including the so-called 2p-2h two-particle-two-hole interactions. Based on these calculations, spectroscopic data on energies and oscillator strengths of the helium atom (the test computation), carbon monoxide, nitrogen molecule, and ethylene are presented that refine some previously reported experimental and theoretical results. It is shown that in some cases the inclusion of polarization corrections introduced by 2p-2h effects is of basic importance because it provides up to ∼30% contribution to the energies and oscillator strengths. 23 refs., 5 tabs

  9. Oscillator strengths for neutral technetium

    International Nuclear Information System (INIS)

    Garstang, R.H.

    1981-01-01

    Oscillator strengths have been calculated for most of the spectral lines of TcI which are of interest in the study of stars of spectral type S. Oscillator strengths have been computed for the corresponding transitions in MnI as a partial check of the technetium calculations

  10. Width and strength of the hot giant dipole resonance. The role of the life time of the compound nucleus and the transition from order to chaos

    International Nuclear Information System (INIS)

    Chomaz, P.

    1996-01-01

    A bump in the γ decay spectrum is observed at high energies which is due to the excitation of the Giant Dipole Resonance (GDR) in the compound nucleus. The fact is discussed that the total width of the γ-ray spectrum of the GDR transitions must contain twice the width of the compound nucleus levels. This implies that one must except a rapid increase of the width of the GDR. This increase contributes to the observed saturation of the photon multiplicity. A new suppression factor due to the lost of collectivity induced by the fast particle emission is proposed. (K.A.)

  11. Photochemical Aryl Radical Cyclizations to Give (E-3-Ylideneoxindoles

    Directory of Open Access Journals (Sweden)

    Michael Gurry

    2014-09-01

    Full Text Available (E-3-Ylideneoxindoles are prepared in methanol in reasonable to good yields, as adducts of photochemical 5-exo-trig of aryl radicals, in contrast to previously reported analogous radical cyclizations initiated by tris(trimethylsilylsilane and azo-initiators that gave reduced oxindole adducts.

  12. Apolipoprotein E*3-Leiden transgenic mice mode for hypolipidaemic drugs

    NARCIS (Netherlands)

    Vlijmen, B.J.M. van; Pearce, N.J.; Bergö, M.; Staels, B.; Yates, J.W.; Gribble, A.D.; Bond, B.C.; Hofker, M.H.; Havekes, L.M.; Groot, P.H.E.

    1998-01-01

    Apolipoprotein (APO) E*3-Leiden mice with impaired chylomicron and VLDL (very low density lipoprotein) remnant metabolism display hyperlipidaemia and atherosclerosis. In the present study, these mice were used for testing the hypolipidaemic effect of two marketed agents, lovastatin (CAS 75330-75-5)

  13. Lunar Penetrating Radar onboard the Chang'e-3 mission

    Science.gov (United States)

    Fang, Guang-You; Zhou, Bin; Ji, Yi-Cai; Zhang, Qun-Ying; Shen, Shao-Xiang; Li, Yu-Xi; Guan, Hong-Fei; Tang, Chuan-Jun; Gao, Yun-Ze; Lu, Wei; Ye, Sheng-Bo; Han, Hai-Dong; Zheng, Jin; Wang, Shu-Zhi

    2014-12-01

    Lunar Penetrating Radar (LPR) is one of the important scientific instruments onboard the Chang'e-3 spacecraft. Its scientific goals are the mapping of lunar regolith and detection of subsurface geologic structures. This paper describes the goals of the mission, as well as the basic principles, design, composition and achievements of the LPR. Finally, experiments on a glacier and the lunar surface are analyzed.

  14. Energy Exascale Earth System Model (E3SM) Project Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Bader, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-18

    The E3SM project will assert and maintain an international scientific leadership position in the development of Earth system and climate models at the leading edge of scientific knowledge and computational capabilities. With its collaborators, it will demonstrate its leadership by using these models to achieve the goal of designing, executing, and analyzing climate and Earth system simulations that address the most critical scientific questions for the nation and DOE.

  15. Allowed and forbidden transition parameters for Fe XV

    International Nuclear Information System (INIS)

    Nahar, Sultana N.

    2009-01-01

    A comprehensive set of fine structure energy levels, oscillator strengths (f), line strengths (S), and radiative decay rates (A) for bound-bound transitions in Fe XV is presented. The allowed electric dipole (E1) transitions were obtained from the relativistic Breit-Pauli R-matrix method which is based on the close coupling approximation. A total of 507 fine structure energy levels with n ≤ 10, l ≤ 9, and 0 ≤ J ≤ 10 are found. They agree within 1% with the available observed energies. These energy levels yield a total of 27,812 E1, same-spin multiplets and intercombination transitions. The A values are in good agreement with those compiled by NIST and other existing values for most transitions. Forbidden transitions are obtained from a set of 20 configurations with orbitals ranging from 1s to 5f using the relativistic code SUPERSTRUCTURE (SS) in the Breit-Pauli approximation. From a set of 123 fine structure levels, a total of 6962 S and A values are presented for forbidden electric quadrupole (E2), electric octupole (E3), magnetic dipole (M1), and magnetic quadrupole (M2) transitions. The energies from SS calculations agree with observed energies to within 1-3%. A values for E2, M1 transitions agree very well with the available values for most transitions while those for M2 transitions show variable agreement. The large set of transition parameters presented should be applicable for both diagnostics and spectral modeling in the X-ray, ultraviolet, and optical regions of astrophysical plasmas.

  16. Some Preliminary Scientific Results of Chang'E-3 Mission

    Science.gov (United States)

    Zou, Y.; Li, W.; Zheng, Y.; Li, H.

    2015-12-01

    Chang'E-3 mission is the main task of Phase two of China Lunar Exploration Program (CLEP), and also is Chinese first probe of landing, working and roving on the moon. Chang'E-3 craft composed of a lander and a rover, and each of them carry four scientific payloads respectively. The landing site of Chang'E-3 was located at 44.12 degrees north latitude and 19.51 degrees west longitude, where is in the northern part of Imbrium Which the distance in its west direction from the landing site of former Soviet probe Luna-17 is about 400 km, and about 780km far from the landing site of Appolo-17 in its southeast direction. Unfortunately, after a series of scientific tests and exploration on the surface of the moon, the motor controller communication of the rover emerged a breakdown on January 16, 2014, which leaded the four payloads onboard the rover can't obtain data anymore. However, we have received some interesting scientific data which have been studied by Chinese scientists. During the landing process of Chang'E-3, the Landing camera got total 4673 images with the Resolution in millimeters to meters, and the lander and rover took pictures for each other at different point with Topography camera and Panoramic camera. We can find characteristic changes in celestial brightness with time by analyzing image data from Lunar-based Ultraviolet Telescope (LUT) and an unprecedented constraint on water content in the sunlit lunar exosphere seen by LUT). The figure observed by EUV camera (EUVC) shows that there is a transient weak area of the Earth's plasma sphere; This event took place about three hours. The scientists think that it might be related to the change of the particle density of mid-latitude ionosphere. The preliminary spectral and mineralogical results from the landing site are derived according to the data of Visible and Near-infrared Imaging Spectrometer (VNIS). Seven major elements including Mg, Al, Si, K, Ca, Ti and Fe have been identified by the Active Particle

  17. E3D, 3-D Elastic Seismic Wave Propagation Code

    International Nuclear Information System (INIS)

    Larsen, S.; Harris, D.; Schultz, C.; Maddix, D.; Bakowsky, T.; Bent, L.

    2004-01-01

    1 - Description of program or function: E3D is capable of simulating seismic wave propagation in a 3D heterogeneous earth. Seismic waves are initiated by earthquake, explosive, and/or other sources. These waves propagate through a 3D geologic model, and are simulated as synthetic seismograms or other graphical output. 2 - Methods: The software simulates wave propagation by solving the elasto-dynamic formulation of the full wave equation on a staggered grid. The solution scheme is 4-order accurate in space, 2-order accurate in time

  18. Aspects of radiative K{sup +}{sub e3} decays

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, B. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany); Mueller, E.H. [Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany); University of Edinburgh, School of Physics, Edinburgh (United Kingdom); Gasser, J.; Schmid, M. [Universitaet Bern, Institut fuer theoretische Physik, Bern (Switzerland)

    2007-04-15

    We re-investigate the radiative charged kaon decay K{sup {+-}}{yields}{pi}{sup 0}e{sup {+-}}{nu}{sub e}{gamma} [K{sub e3{gamma}}{sup {+-}}] in chiral perturbation theory, merging the chiral expansion with Low's theorem. We thoroughly analyze the precision of the predicted branching ratio relative to the non-radiative decay channel. Structure dependent terms and their impact on differential decay distributions are investigated in detail, and the possibility to see effects of the chiral anomaly in this decay channel is emphasized. (orig.)

  19. Aspects of radiative K+e3 decays

    International Nuclear Information System (INIS)

    Kubis, B.; Mueller, E.H.; Gasser, J.; Schmid, M.

    2007-01-01

    We re-investigate the radiative charged kaon decay K ± →π 0 e ± ν e γ [K e3γ ± ] in chiral perturbation theory, merging the chiral expansion with Low's theorem. We thoroughly analyze the precision of the predicted branching ratio relative to the non-radiative decay channel. Structure dependent terms and their impact on differential decay distributions are investigated in detail, and the possibility to see effects of the chiral anomaly in this decay channel is emphasized. (orig.)

  20. Implication of SUMO E3 ligases in nucleotide excision repair.

    Science.gov (United States)

    Tsuge, Maasa; Kaneoka, Hidenori; Masuda, Yusuke; Ito, Hiroki; Miyake, Katsuhide; Iijima, Shinji

    2015-08-01

    Post-translational modifications alter protein function to mediate complex hierarchical regulatory processes that are crucial to eukaryotic cellular function. The small ubiquitin-like modifier (SUMO) is an important post-translational modification that affects transcriptional regulation, nuclear localization, and the maintenance of genome stability. Nucleotide excision repair (NER) is a very versatile DNA repair system that is essential for protection against ultraviolet (UV) irradiation. The deficiencies in NER function remarkably increase the risk of skin cancer. Recent studies have shown that several NER factors are SUMOylated, which influences repair efficiency. However, how SUMOylation modulates NER has not yet been elucidated. In the present study, we performed RNAi knockdown of SUMO E3 ligases and found that, in addition to PIASy, the polycomb protein Pc2 affected the repair of cyclobutane pyrimidine dimers. PIAS1 affected both the removal of 6-4 pyrimidine pyrimidone photoproducts and cyclobutane pyrimidine dimers, whereas other SUMO E3 ligases did not affect the removal of either UV lesion.

  1. Trajectory Determination for Chang 'e-3 Probe Soft-landing

    Science.gov (United States)

    Yezhi, S.; Huang, Y.

    2017-12-01

    On December 2, 2013, The Chang 'e-3 (ce-3) probe was successfully launched from a long march-3b carrier rocket at Xichang satellite launch center. After more than five days of flying, the probe was captured by the moon to 100 km by 100 km. The orbit maneuvered to 15 km by 100 km 4 days later. Finally, at 21:12 Beijing time on December 14, 2013, it landed at the junction of the Sinus Iridum and Mare Imbrium. In the ce-3 project, the combined test mode of the radio ranging measurement and very long baseline interferometry (VLBI) was used. The soft-landing was carried out in ce-3 mission for the sampling .The paper presents a new method of trajectory determination for soft landing and sampling returning for lunar probe by B spline approximation. By simulation and data processing of Chang'E-3(CE-3), it could be assumed that the accuracy of trajectory determination of soft landing is less than 100 meters in CE-3. It appears that the difference between the endpoint of trajectory and the location from image processed by NASA'S LRO is less than 50m .It confirms the method of soft landing trajectory determination provided by the paper is effective. The paper analyzes the dynamics and control characteristics of the sampling returning, provides the preliminary feasible trajectory determination method for soft landing and sampling return of Chang'E-5 (CE - 5).

  2. E3 analysis for crude and vacuum distillation system

    Energy Technology Data Exchange (ETDEWEB)

    Mittal, V; Zhang, J; Yang, X; Xu, Q [Dan F. Smith Department of Chemical Engineering, Lamar University, Beaumont, Texas (United States)

    2011-11-15

    Crude oil blending is a very common practice in petroleum refineries, where the main focus is to minimize the total purchase cost of crude oils under specified blending oil properties. Crude oil blending actually has significant impacts on energy consumption from heating furnaces during crude oil processing. Conceivably, furnace energy consumption from burning fuels such as natural gas, fuel oil, or propane causes huge amounts of CO{sub 2} emissions. In this paper, a methodology framework for crude oil blending and processing with simultaneous consideration of energy, emission, and economic profit (E3) is developed. It includes four stages of work: steady-state modeling, heating energy consumption calculation, emission model development, and economic evaluation. With Aspen HYSYS simulation, the developed methodology provides a quantitative support for refinery to identify an optimal E3 operating strategy. A case study is implemented to demonstrate the efficacy of this methodology. (Copyright copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. Performance Measurement of Advanced Stirling Convertors (ASC-E3)

    Science.gov (United States)

    Oriti, Salvatore M.

    2013-01-01

    NASA Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG project is providing life, reliability, and performance testing data of the Advanced Stirling Convertor (ASC). The latest version of the ASC (ASC-E3, to represent the third cycle of engineering model test hardware) is of a design identical to the forthcoming flight convertors. For this generation of hardware, a joint Sunpower and GRC effort was initiated to improve and standardize the test support hardware. After this effort was completed, the first pair of ASC-E3 units was produced by Sunpower and then delivered to GRC in December 2012. GRC has begun operation of these units. This process included performance verification, which examined the data from various tests to validate the convertor performance to the product specification. Other tests included detailed performance mapping that encompassed the wide range of operating conditions that will exist during a mission. These convertors were then transferred to Lockheed Martin for controller checkout testing. The results of this latest convertor performance verification activity are summarized here.

  4. Fatigue properties for the fracture strength of columnar accessory minerals embedded within metamorphic tectonites: implications for stress magnitude in continental crust at the depth of the brittle-plastic transition zone

    Science.gov (United States)

    Kimura, N.; Iwashita, N.; Masuda, T.

    2009-04-01

    1. Introduction Previous studies have compiled yield-strength profiles of continental lithosphere based on the results of laboratory measurements and numerical calculations; however, yield-strength values remain poorly constrained, especially at depths below the brittle-plastic transition zone. Recent studies by the authors have refined the microboudin technique for estimating palaeostress magnitude in the deep crust (> 10 km depth). This technique has the potential to provide important information on stress levels in the deep continental crust, an environment to which available in situ stress measurements and palaeopiezometric methods cannot be applied. In applying the microboudinage technique, obtaining an estimate of the palaeostress magnitude requires knowledge of the fracture strength of columnar accessory minerals (e.g., tourmaline, amphibole, and epidote) that are subjected to brittle fracturing during plastic deformation of the surrounding matrix minerals. The absolute magnitude of fracture strength is known to show a marked reduction in the case of fatigue fracture. Fatigue fracture falls into two categories: static fatigue and cyclic fatigue. In the field of experimental rock deformation, stress corrosion by water molecules (static fatigue) is commonly invoked as the mechanism of fatigue fracture; however, evidence of both static and cyclic fatigue has been reported from studies of natural geological samples. The present study focused on the fatigue properties of columnar accessory minerals at high temperatures, with the aim of improving the accuracy of estimates of natural palaeostress magnitude at depth in the crust. 2. Constant stress-rate test A constant stress-rate test was performed to determine the influence of static fatigue on the strength of columnar accessory minerals. The test was conducted under three-point bending with a span distance of 10 mm. Temperature conditions and the crosshead speed were set in the ranges of ambient to 600°C, and 0

  5. Radiative K{sub e3} decays revisited

    Energy Technology Data Exchange (ETDEWEB)

    Gasser, J. [Universitaet Bern, Institut fuer Theoretische Physik, Bern (Switzerland); Kubis, B. [Universitaet Bern, Institut fuer Theoretische Physik, Bern (Switzerland); Universitaet Bonn, Helmholtz-Institut fuer Strahlen- und Kernphysik, Bonn (Germany); Paver, N. [Universita degli Studi di Trieste, Dipartimento di Fisica Teorica, Trieste (Italy); INFN-Trieste, Trieste (Italy); Verbeni, M. [Universidad de Granada, Departamento de Fisica Teorica y del Cosmos, Granada (Spain)

    2005-03-01

    Motivated by recent experimental results and ongoing measurements, we review the chiral perturbation theory prediction for K{sub L}{yields}{pi}{sup -+}e{sup {+-}}{nu}{sub e}{gamma} decays. Special emphasis is given to the stability of the inner bremsstrahlung-dominated relative branching ratio versus the K{sub e3} form factors, and on the separation of the structure-dependent amplitude in differential distributions over the phase space. For the structure-dependent terms, an assessment of the order p{sup 6} corrections is given, in particular, a full next-to-leading order calculation of the axial component is performed. The experimental analysis of the photon energy spectrum is discussed, and other potentially useful distributions are introduced. (orig.)

  6. The EISCAT_3D Project in Norway: E3DN

    Science.gov (United States)

    La Hoz, C.; Oksavik, K.

    2013-12-01

    EISCAT_3D (E3D) is a project to build the next generation of incoherent scatter radars endowed with 3-dimensional scalar and vector capabilities that will replace the current EISCAT radars in Northern Scandinavia. One active (transmitting) site in Norway and four passive (receiving) sites in the Nordic countries will provide 3-D vector imaging capabilities by rapid scanning and multi-beam forming. The unprecedented flexibility of the solid-state transmitter with high duty-cycle, arbitrary wave-forming and polarisation and its pulsed power of 10 MW will provide unrivalled experimental capabilities to investigate the highly non-stationary and non-homogeneous state of the polar upper atmosphere. Aperture Synthesis Imaging Radar (ASIR) will to endow E3D with imaging capabilities in 3-dimensions that includes sub-beam resolution. Complemented by pulse compression, it will provide 3-dimensional images of certain types of incoherent scatter radar targets resolved to about 100 metres at 100 km range, depending on the signal-to-noise ratio. The Norwegian scientific programme is inspired by the pioneer polar scientist Kristian Birkeland (picture) and includes pressing questions on polar upper atmospheric research, among others: (Q1) How to proceed beyond the present simplistic, static, stationary and homogeneous analysis of upper atmospheric and ionospheric processes? (Q2) How does space weather affect ionospheric processes and how to support modelling and space weather services? (Q3) How to advance fundamental plasma physics by employing the ionosphere as a natural plasma physics laboratory? (Q4) How does the influx of extraterrestrial material interact with the upper atmosphere and where does the material originate from? (Q5) How does solar activity couple from geospace into the lower atmosphere and climate system, and does this energy change the wave forcing of geospace from below? Kristian Birkeland, Norwegian scientist and pioneer in polar and auroral research.

  7. Payload topography camera of Chang'e-3

    International Nuclear Information System (INIS)

    Yu, Guo-Bin; Liu, En-Hai; Zhao, Ru-Jin; Zhong, Jie; Zhou, Xiang-Dong; Zhou, Wu-Lin; Wang, Jin; Chen, Yuan-Pei; Hao, Yong-Jie

    2015-01-01

    Chang'e-3 was China's first soft-landing lunar probe that achieved a successful roving exploration on the Moon. A topography camera functioning as the lander's “eye” was one of the main scientific payloads installed on the lander. It was composed of a camera probe, an electronic component that performed image compression, and a cable assembly. Its exploration mission was to obtain optical images of the lunar topography in the landing zone for investigation and research. It also observed rover movement on the lunar surface and finished taking pictures of the lander and rover. After starting up successfully, the topography camera obtained static images and video of rover movement from different directions, 360° panoramic pictures of the lunar surface around the lander from multiple angles, and numerous pictures of the Earth. All images of the rover, lunar surface, and the Earth were clear, and those of the Chinese national flag were recorded in true color. This paper describes the exploration mission, system design, working principle, quality assessment of image compression, and color correction of the topography camera. Finally, test results from the lunar surface are provided to serve as a reference for scientific data processing and application. (paper)

  8. Attitude Strength.

    Science.gov (United States)

    Howe, Lauren C; Krosnick, Jon A

    2017-01-03

    Attitude strength has been the focus of a huge volume of research in psychology and related sciences for decades. The insights offered by this literature have tremendous value for understanding attitude functioning and structure and for the effective application of the attitude concept in applied settings. This is the first Annual Review of Psychology article on the topic, and it offers a review of theory and evidence regarding one of the most researched strength-related attitude features: attitude importance. Personal importance is attached to an attitude when the attitude is perceived to be relevant to self-interest, social identification with reference groups or reference individuals, and values. Attaching personal importance to an attitude causes crystallizing of attitudes (via enhanced resistance to change), effortful gathering and processing of relevant information, accumulation of a large store of well-organized relevant information in long-term memory, enhanced attitude extremity and accessibility, enhanced attitude impact on the regulation of interpersonal attraction, energizing of emotional reactions, and enhanced impact of attitudes on behavioral intentions and action. Thus, important attitudes are real and consequential psychological forces, and their study offers opportunities for addressing behavioral change.

  9. Aβ-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1.

    Science.gov (United States)

    Rodrigues, Elizabeth M; Scudder, Samantha L; Goo, Marisa S; Patrick, Gentry N

    2016-02-03

    Alzheimer's disease (AD) is a neurodegenerative disease in which patients experience progressive cognitive decline. A wealth of evidence suggests that this cognitive impairment results from synaptic dysfunction in affected brain regions caused by cleavage of amyloid precursor protein into the pathogenic peptide amyloid-β (Aβ). Specifically, it has been shown that Aβ decreases surface AMPARs, dendritic spine density, and synaptic strength, and also alters synaptic plasticity. The precise molecular mechanisms by which this occurs remain unclear. Here we demonstrate a role for ubiquitination in Aβ-induced synaptic dysfunction in cultured rat neurons. We find that Aβ promotes the ubiquitination of AMPARs, as well as the redistribution and recruitment of Nedd4-1, a HECT E3 ubiquitin ligase we previously demonstrated to target AMPARs for ubiquitination and degradation. Strikingly, we show that Nedd4-1 is required for Aβ-induced reductions in surface AMPARs, synaptic strength, and dendritic spine density. Our findings, therefore, indicate an important role for Nedd4-1 and ubiquitin in the synaptic alterations induced by Aβ. Synaptic changes in Alzheimer's disease (AD) include surface AMPAR loss, which can weaken synapses. In a cell culture model of AD, we found that AMPAR loss correlates with increased AMPAR ubiquitination. In addition, the ubiquitin ligase Nedd4-1, known to ubiquitinate AMPARs, is recruited to synapses in response to Aβ. Strikingly, reducing Nedd4-1 levels in this model prevented surface AMPAR loss and synaptic weakening. These findings suggest that, in AD, Nedd4-1 may ubiquitinate AMPARs to promote their internalization and weaken synaptic strength, similar to what occurs in Nedd4-1's established role in homeostatic synaptic scaling. This is the first demonstration of Aβ-mediated control of a ubiquitin ligase to regulate surface AMPAR expression. Copyright © 2016 the authors 0270-6474/16/361590-06$15.00/0.

  10. Climate Change Communicators: The C3E3 Project

    Science.gov (United States)

    Sharif, H. O.; Joseph, J.

    2013-12-01

    The University of Texas at San Antonio (UTSA), San Antonio College (SAC), and the University of North Dakota (UND) have partnered with NASA to provide underrepresented undergraduates from UTSA, SAC, and other community colleges climate-related research and education experiences through the Climate Change Communication: Engineer, Environmental science, and Education (C3E3) project. The program aims to develop a robust response to climate change by providing K-16 climate change education; enhance the effectiveness of K-16 education particularly in engineering and other STEM disciplines by use of new instructional technologies; increase the enrollment in engineering programs and the number of engineering degrees awarded by showing engineering's usefulness in relation to the much-discussed contemporary issue of climate change; increase persistence in STEM degrees by providing student research opportunities; and increase the ethnic diversity of those receiving engineering degrees and help ensure an ethnically diverse response to climate change. Students participated in the second summer internship funded by the project. More than 60 students participated in guided research experiences aligned with NASA Science Plan objectives for climate and Earth system science and the educational objectives of the three institutions. The students went through training in modern media technology (webcasts), and in using this technology to communicate the information on climate change to others, especially high school students, culminating in production of webcasts on investigating the aspects of climate change using NASA data. Content developed is leveraged by NASA Earth observation data and NASA Earth system models and tools. Several departments are involved in the educational program.

  11. The interactions in K{sub μ3} and K{sub e3} decay

    Energy Technology Data Exchange (ETDEWEB)

    McDowell, S. W. [Brazilian Centre of Research in Physics, Rio de Janeiro (Brazil)

    1963-01-15

    An attractive feature common to all present theories of weak interactions is the assumption that they result from the coupling (either direct or via intermediate bosons) of vector-axial vector currents. The V-A coupling of leptonic currents and baryonic currents conserving strangeness successfully explains the characteristic properties of μ-decay, π-decay and μ-decay. On the other hand, the leptonic decay modes of K-mesons provide the best source of information on the nature of the currents carrying strangeness. From K{sub μ2} one learns that there must exist an axial-vector current carrying strangeness; further, if the leptonic weak interaction is universal, one can explain the absence of the K{sub e2} mode by excluding a pseudo-scalar interaction. From K{sub μ3} and K{sub e3} decay one can obtain information on scalar, vector and tensor coupling of strangeness non-conserving currents with leptons. In recent experiments on K{sub e3} decay a good fitting of the pion spectrum was obtained with a constant vector form factor. Although regarding this result as strong evidence of pure vector coupling, one might still argue that other possibilities, such as a mixture of vector and tensor couplings with energy-dependent form factors, are not excluded. I shall discuss here, in the first place, some properties of the transition amplitudes which are independent of the structure of form factors. They provide a test of universality and a criterion for unambiguous determination of the nature of the weak interaction involved in these processes. Secondly, I shall discuss the structure of form factors, by means of dispersion relations and introducing explicitly the effect of the K*-resonance in the Kπ-interaction.

  12. Global Kinetic Analysis of Mammalian E3 Reveals pH-dependent NAD+/NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum*

    Science.gov (United States)

    Moxley, Michael A.; Beard, Daniel A.; Bazil, Jason N.

    2016-01-01

    Mammalian E3 is an essential mitochondrial enzyme responsible for catalyzing the terminal reaction in the oxidative catabolism of several metabolites. E3 is a key regulator of metabolic fuel selection as a component of the pyruvate dehydrogenase complex (PDHc). E3 regulates PDHc activity by altering the affinity of pyruvate dehydrogenase kinase, an inhibitor of the enzyme complex, through changes in reduction and acetylation state of lipoamide moieties set by the NAD+/NADH ratio. Thus, an accurate kinetic model of E3 is needed to predict overall mammalian PDHc activity. Here, we have combined numerous literature data sets and new equilibrium spectroscopic experiments with a multitude of independently collected forward and reverse steady-state kinetic assays using pig heart E3. The latter kinetic assays demonstrate a pH-dependent transition of NAD+ activation to inhibition, shown here, to our knowledge, for the first time in a single consistent data set. Experimental data were analyzed to yield a thermodynamically constrained four-redox-state model of E3 that simulates pH-dependent activation/inhibition and active site redox states for various conditions. The developed model was used to determine substrate/product conditions that give maximal E3 rates and show that, due to non-Michaelis-Menten behavior, the maximal flux is different compared with the classically defined kcat. PMID:26644471

  13. Topological strength of magnetic skyrmions

    Energy Technology Data Exchange (ETDEWEB)

    Bazeia, D.; Ramos, J.G.G.S.; Rodrigues, E.I.B.

    2017-02-01

    This work deals with magnetic structures that attain integer and half-integer skyrmion numbers. We model and solve the problem analytically, and show how the solutions appear in materials that engender distinct, very specific physical properties, and use them to describe their topological features. In particular, we found a way to model skyrmion with a large transition region correlated with the presence of a two-peak skyrmion number density. Moreover, we run into the issue concerning the topological strength of a vortex-like structure and suggest an experimental realization, important to decide how to modify and measure the topological strength of the magnetic structure.

  14. Bond strength of masonry

    NARCIS (Netherlands)

    Pluijm, van der R.; Vermeltfoort, A.Th.

    1992-01-01

    Bond strength is not a well defined property of masonry. Normally three types of bond strength can be distinguished: - tensile bond strength, - shear (and torsional) bond strength, - flexural bond strength. In this contribution the behaviour and strength of masonry in deformation controlled uniaxial

  15. Soft radiative strength in warm nuclei

    International Nuclear Information System (INIS)

    Becker, J A; Bernstein, L A; Garrett, P E; Nelson, R O; Schiller, A; Voinov, A; Agvaanluvsan, U; Algin, E; Belgya, T; Chankova, R; Guttormsen, M; Mitchell, G E; Rekstad, J; Siem, S

    2004-01-01

    Unresolved transitions in the nuclear γ-ray cascade produced in the decay of excited nuclei are best described by statistical concepts: a continuous radiative strength function (RSF) and level density yield mean values of transition matrix elements. Data on the soft (E γ < 3-4 MeV) RSF for transitions between warm states (i.e. states several MeV above the yrast line) have, however, remained elusive

  16. The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo

    International Nuclear Information System (INIS)

    Vijaysri, Sangeetha; Talasela, Latha; Mercer, Andrew A.; Mcinnes, Colin J.; Jacobs, Bertram L.; Langland, Jeffrey O.

    2003-01-01

    Orf virus (OV), the prototypic parapoxvirus, is resistant to the effects of interferon (IFN) and this function of OV has been mapped to the OV20.0L gene. The protein product of this gene shares 31% amino acid identity to the E3L-encoded protein of vaccinia virus (VV) that is required for the broad host range and IFN-resistant phenotype of VV in cells in culture and for virulence of the virus in vivo. In this study we investigated whether the distantly related OV E3L homologue could complement the deletion of E3L in VV. The recombinant VV (VV/ORF-E3L) expressing the OV E3L homologue in place of VV E3L was indistinguishable from wt VV in its cell-culture phenotype. But VV/ORF-E3L was over a 1000-fold less pathogenic than wt VV (LD 50 > 5 x 10 6 PFU, compared to LD 50 of wtVV = 4 x 10 3 PFU) following intranasal infection of mice. While wt VV spread to the lungs and brain and replicated to high titers in the brain of infected mice, VV/ORF-E3L could not be detected in the lungs or brain following intranasal infection. VV/ORF-E3L was at least 100,000-fold less pathogenic than wt VV on intracranial injection. Domain swap experiments demonstrate that the difference in pathogenesis maps to the C-terminal domain of these proteins. This domain has been shown to be required for the dsRNA binding function of the VV E3L

  17. Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling.

    Directory of Open Access Journals (Sweden)

    Wei Li

    2008-01-01

    Full Text Available Specificity of protein ubiquitylation is conferred by E3 ubiquitin (Ub ligases. We have annotated approximately 617 putative E3s and substrate-recognition subunits of E3 complexes encoded in the human genome. The limited knowledge of the function of members of the large E3 superfamily prompted us to generate genome-wide E3 cDNA and RNAi expression libraries designed for functional screening. An imaging-based screen using these libraries to identify E3s that regulate mitochondrial dynamics uncovered MULAN/FLJ12875, a RING finger protein whose ectopic expression and knockdown both interfered with mitochondrial trafficking and morphology. We found that MULAN is a mitochondrial protein - two transmembrane domains mediate its localization to the organelle's outer membrane. MULAN is oriented such that its E3-active, C-terminal RING finger is exposed to the cytosol, where it has access to other components of the Ub system. Both an intact RING finger and the correct subcellular localization were required for regulation of mitochondrial dynamics, suggesting that MULAN's downstream effectors are proteins that are either integral to, or associated with, mitochondria and that become modified with Ub. Interestingly, MULAN had previously been identified as an activator of NF-kappaB, thus providing a link between mitochondrial dynamics and mitochondria-to-nucleus signaling. These findings suggest the existence of a new, Ub-mediated mechanism responsible for integration of mitochondria into the cellular environment.

  18. Electric quadrupole strength in nuclei

    International Nuclear Information System (INIS)

    Kirson, M.W.

    1979-01-01

    Isoscalar electric quadrupole strength distributions in nuclei are surveyed, and it is concluded that the strength is shared, in most cases, roughly equally between low-lying transitions and the giant quadrupole state. The same is not true of the isovector case. A simple extension of the schematic model gives a remarkably successul description of the data, and emphasizes the vital importance of the coupling between high-lying and low-lying quadrupole modes. The standadrd simple representation of the giant quadrupole resonance as produced by operating on the nuclear ground state with the quadrupole transition operator is not applicable to the isoscalar case. It is suggested that giant resonances fall into broad classes of similar states, with considerable qualitative differences between the distinct classes. (author)

  19. Quantum phase transitions

    International Nuclear Information System (INIS)

    Sachdev, S.

    1999-01-01

    Phase transitions are normally associated with changes of temperature but a new type of transition - caused by quantum fluctuations near absolute zero - is possible, and can tell us more about the properties of a wide range of systems in condensed-matter physics. Nature abounds with phase transitions. The boiling and freezing of water are everyday examples of phase transitions, as are more exotic processes such as superconductivity and superfluidity. The universe itself is thought to have passed through several phase transitions as the high-temperature plasma formed by the big bang cooled to form the world as we know it today. Phase transitions are traditionally classified as first or second order. In first-order transitions the two phases co-exist at the transition temperature - e.g. ice and water at 0 deg., or water and steam at 100 deg. In second-order transitions the two phases do not co-exist. In the last decade, attention has focused on phase transitions that are qualitatively different from the examples noted above: these are quantum phase transitions and they occur only at the absolute zero of temperature. The transition takes place at the ''quantum critical'' value of some other parameter such as pressure, composition or magnetic field strength. A quantum phase transition takes place when co-operative ordering of the system disappears, but this loss of order is driven solely by the quantum fluctuations demanded by Heisenberg's uncertainty principle. The physical properties of these quantum fluctuations are quite distinct from those of the thermal fluctuations responsible for traditional, finite-temperature phase transitions. In particular, the quantum system is described by a complex-valued wavefunction, and the dynamics of its phase near the quantum critical point requires novel theories that have no analogue in the traditional framework of phase transitions. In this article the author describes the history of quantum phase transitions. (UK)

  20. Modulated magnetic structure of F e3P O7 as seen by 57Fe Mössbauer spectroscopy

    Science.gov (United States)

    Sobolev, A. V.; Akulenko, A. A.; Glazkova, I. S.; Pankratov, D. A.; Presniakov, I. A.

    2018-03-01

    The paper reports results of the 57Fe Mössbauer measurements on an F e3P O4O3 powder sample recorded at various temperatures, including the point of magnetic phase transition TN≈163 K . The spectra measured above TN consist of a quadrupole doublet with high quadrupole splitting of Δ300 K≈1.10 mm /s , emphasizing that F e3 + ions are located in crystal positions with a strong electric-field gradient (EFG). To predict the sign and orientation of the main components of the EFG tensor, we calculated the EFG using the density-functional-theory approach. In the temperature range T spiral spin structure results from easy-axis anisotropy in the plane of the iron spin rotation. The temperature evolution of the hyperfine field Hhf(T ) was described by the Bean-Rodbell model, which takes into account that the exchange magnetic interactions are a strong function of the lattice spacing. The obtained Mössbauer data are in qualitative agreement with previous neutron-diffraction data for a modulated helical magnetic structure in strongly frustrated F e3P O4O3 .

  1. Functional characterization of DnSIZ1, a SIZ/PIAS-type SUMO E3 ligase from Dendrobium.

    Science.gov (United States)

    Liu, Feng; Wang, Xiao; Su, Mengying; Yu, Mengyuan; Zhang, Shengchun; Lai, Jianbin; Yang, Chengwei; Wang, Yaqin

    2015-09-17

    SUMOylation is an important post-translational modification of eukaryotic proteins that involves the reversible conjugation of a small ubiquitin-related modifier (SUMO) polypeptide to its specific protein substrates, thereby regulating numerous complex cellular processes. The PIAS (protein inhibitor of activated signal transducers and activators of transcription [STAT]) and SIZ (scaffold attachment factor A/B/acinus/PIAS [SAP] and MIZ) proteins are SUMO E3 ligases that modulate SUMO conjugation. The characteristic features and SUMOylation mechanisms of SIZ1 protein in monocotyledon are poorly understood. Here, we examined the functions of a homolog of Arabidopsis SIZ1, a functional SIZ/PIAS-type SUMO E3 ligase from Dendrobium. In Dendrobium, the predicted DnSIZ1 protein has domains that are highly conserved among SIZ/PIAS-type proteins. DnSIZ1 is widely expressed in Dendrobium organs and has a up-regulated trend by treatment with cold, high temperature and wounding. The DnSIZ1 protein localizes to the nucleus and shows SUMO E3 ligase activity when expressed in an Escherichia coli reconstitution system. Moreover, ectopic expression of DnSIZ1 in the Arabidopsis siz1-2 mutant partially complements several phenotypes and results in enhanced levels of SUMO conjugates in plants exposed to heat shock conditions. We observed that DnSIZ1 acts as a negative regulator of flowering transition which may be via a vernalization-induced pathway. In addition, ABA-hypersensitivity of siz1-2 seed germination can be partially suppressed by DnSIZ1. Our results suggest that DnSIZ1 is a functional homolog of the Arabidopsis SIZ1 with SUMO E3 ligase activity and may play an important role in the regulation of Dendrobium stress responses, flowering and development.

  2. 10 CFR 830 Major Modification Determination for the ATR Diesel Bus (E-3) and Switchgear Replacement

    International Nuclear Information System (INIS)

    Duckwitz, Noel

    2011-01-01

    Near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE's long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project, subject of this determination, will replace the existent diesel-electrical bus (E-3) and associated switchgear. More specifically, INL proposes transitioning ATR to 100% commercial power with appropriate emergency backup to include: (1) Provide commercial power as the normal source of power to the ATR loads currently supplied by diesel-electric power. (2) Provide backup power to the critical ATR loads in the event of a loss of commercial power. (3) Replace obsolescent critical ATR power distribution equipment, e.g., switchgear, transformers, motor control centers, distribution panels. Completion of this and two other age-related projects (primary coolant pump and motor replacement and emergency firewater injection system replacement) will resolve major age related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues make the project a major modification: (1) Evaluation Criteria No.2 (Footprint change). The addition of a new PC-4 structure to the ATR Facility to house safety-related SSCs requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., structural qualification, fire suppression) to ensure no adverse impacts to the safety-related functions of the housed equipment. (2) Evaluation Criteria No.3 (Change of existing process). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps requires careful attention and analysis to ensure it meets a project primary

  3. Electronic and structural properties of B i2S e3:Cu

    Science.gov (United States)

    Sobczak, Kamil; Strak, Pawel; Kempisty, Pawel; Wolos, Agnieszka; Hruban, Andrzej; Materna, Andrzej; Borysiuk, Jolanta

    2018-04-01

    Electronic and structural properties of B i2S e3 and its extension to copper doped B i2S e3:Cu were studied using combined ab initio simulations and transmission electron microscopy based techniques, including electron energy loss spectroscopy, energy filtered transmission electron microscopy, and energy dispersive x-ray spectroscopy. The stability of the mixed phases was investigated for substitutional and intercalation changes of basic B i2S e3 structure. Four systems were compared: B i2S e3 , structures obtaining by Cu intercalation of the van der Waals gap, by substitution of Bi by Cu in quintuple layers, and C u2Se . The structures were identified and their electronic properties were obtained. Transmission electron microscopy measurements of B i2S e3 and the B i2S e3:Cu system identified the first structure as uniform and the second as composite, consisting of a nonuniform lower-Cu-content matrix and randomly distributed high-Cu-concentration precipitates. Critical comparison of the ab initio and experimental data identified the matrix as having a B i2S e3 dominant part with randomly distributed Cu-intercalated regions having 1Cu-B i2S e3 structure. The precipitates were determined to have 3Cu-B i2S e3 structure.

  4. The Strength Compass

    DEFF Research Database (Denmark)

    Ledertoug, Mette Marie

    In the Ph.D-project ͚Strengths-based Learning - Children͛s character strengths as a means to their learning potential͛ 750 Danish children have assessed ͚The Strength Compass͛ in order to identify their strengths and to create awareness of strengths. This was followed by a strengths......-based intervention program in order to explore the strengths. Finally different methods to apply the strength in everyday life at school were applied. The paper presentation will show the results for strengths display for children aged 6-16 in different categories: Different age groups: Are the same strengths...... present in both small children and youths? Gender: Do the results show differences between the two genders? Danish as a mother- tongue language: Do the results show any differences in the strengths display when considering different language and cultural backgrounds? Children with Special Needs: Do...

  5. Families in Transition .

    Science.gov (United States)

    Bundy, Michael L., Ed.; Gumaer, James, Ed.

    1984-01-01

    Focuses on disrupted families and the role of the school counselor in helping children adjust. Describes characteristics of healthy families, and discusses the transition to the blended family, effects of divorce groups on children's classroom behavior, counseling children in stepfamilies, single-parent families, and parenting strengths of single…

  6. Evaluation of the energy-climate package with the help of Gemini-E3 Model

    International Nuclear Information System (INIS)

    Vielle, M.; Moulinier, J.M.; Bernard, A.

    2009-01-01

    This article presents an evaluation of the energy-climate package carried out at the request of the Ministry of Sustainable Development (MEEDDAT) by simulating several scenarios on the general calculable equilibrium model GEMINI-E3. The analysis was carried out during the European negotiations in very close collaboration with the services of the Ministry and has thus constituted a useful tool for deciding and defining the position of France, which, besides, chaired the Union in the course of the transition period of the second half of 2008 and was in charge of finding and gaining acceptance of a compromise between all the member countries, while taking into account the aspirations of the professionals most closely involved. As one might guess, the study shows that the easing of constraints through mechanisms of flexibility yields reductions in the cost of European policy on climate change, particularly for the achievement of the main objective, viz. the 20% reduction of greenhouse gas emissions by 2020. This cost is reasonable, although its distribution between countries is neither homogeneous, nor in conformity with concerns over equity. Many indirect effects of the policy on climate change, in particular the gains or losses caused by the modification of the terms of trade, may significantly upset the hierarchy of direct costs. This article also looks into the carbon leakage issue and suggests, in particular, favouring the net leakage concept, this being the discrepancy between the additional emissions in non-annex B countries and those which would have been incurred if production in response to demand from annex B countries relatively insensitive to the policy o climatic change, had not been relocated. Another feature of this study is an evaluation, after the event, of the extent to which the use of a modelling tool has effectively allowed identification of the issues raised in the course of the European negotiation, and to provide relevant answers. (authors)

  7. (e,3e) collisions on He in the quasi-dipolar regime

    International Nuclear Information System (INIS)

    Taouil, I.; Lahmam-Bennani, A.; Duguet, A.

    1999-01-01

    We report the first measurement of the angular distributions of the two ejected electrons following electron impact double ionization of helium, using a multi-parameter (e,3e) spectrometer. The high incident energy of these experiments allows comparison with photo-double ionization results. Comparison is also made with existing (e,3e) theoretical calculations. (orig.)

  8. PXR agonism decreases plasma HDL levels in ApoE*3-Leiden.CETP mice

    NARCIS (Netherlands)

    Haan, W. de; Vries-van der Weij, J. de; Mol, I.M.; Hoekstra, M.; Romijn, J.A.; Jukema, J.W.; Havekes, L.M.; Princen, H.M.G.; Rensen, P.C.N.

    2009-01-01

    Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR agonism on HDL metabolism in ApoE*3-Leiden (E3L) and

  9. G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization

    International Nuclear Information System (INIS)

    Brooks, William S.; Banerjee, Sami; Crawford, David F.

    2007-01-01

    G2E3 was originally described as a G2/M-specific gene with DNA damage responsive expression. The presence of a conserved HECT domain within the carboxy-terminus of the protein indicated that it likely functions as a ubiquitin ligase or E3. Although HECT domains are known to function in this capacity for many proteins, we demonstrate that a portion of the HECT domain from G2E3 plays an important role in the dynamic subcellular localization of the protein. We have shown that G2E3 is a nucleo-cytoplasmic shuttling protein with nuclear export mediated by a novel nuclear export domain that functions independently of CRM1. In full-length G2E3, a separate region of the HECT domain suppresses the function of the NES. Additionally, G2E3 contains a nucleolar localization signal (NoLS) in its amino terminus. Localization of G2E3 to the nucleolus is a dynamic process, and the protein delocalizes from the nucleolus rapidly after DNA damage. Cell cycle phase-specific expression and highly regulated subcellular localization of G2E3 suggest a possible role in cell cycle regulation and the cellular response to DNA damage

  10. Procedure Redesign Methods : E3-Control: a redesign methodology for control procedures

    NARCIS (Netherlands)

    Liu, J.; Hofman, W.J.; Tan, Y.H.

    2011-01-01

    This chapter highlights the core research methodology, e3-control, that is applied throughout the ITAIDE project for the purpose of control procedure redesign. We present the key concept of the e3-control methodology and its technical guidelines. Based on the output of this chapter, domain experts

  11. 17 CFR 270.22e-3 - Exemption for liquidation of money market funds.

    Science.gov (United States)

    2010-04-01

    ... money market funds. 270.22e-3 Section 270.22e-3 Commodity and Securities Exchanges SECURITIES AND... for liquidation of money market funds. (a) Exemption. A registered open-end management investment company or series thereof (“fund”) that is regulated as a money market fund under § 270.2a-7 is exempt...

  12. Map-Based Cloning of the Gene Associated With the Soybean Maturity Locus E3

    Science.gov (United States)

    Watanabe, Satoshi; Hideshima, Rumiko; Xia, Zhengjun; Tsubokura, Yasutaka; Sato, Shusei; Nakamoto, Yumi; Yamanaka, Naoki; Takahashi, Ryoji; Ishimoto, Masao; Anai, Toyoaki; Tabata, Satoshi; Harada, Kyuya

    2009-01-01

    Photosensitivity plays an essential role in the response of plants to their changing environments throughout their life cycle. In soybean [Glycine max (L.) Merrill], several associations between photosensitivity and maturity loci are known, but only limited information at the molecular level is available. The FT3 locus is one of the quantitative trait loci (QTL) for flowering time that corresponds to the maturity locus E3. To identify the gene responsible for this QTL, a map-based cloning strategy was undertaken. One phytochrome A gene (GmPhyA3) was considered a strong candidate for the FT3 locus. Allelism tests and gene sequence comparisons showed that alleles of Misuzudaizu (FT3/FT3; JP28856) and Harosoy (E3/E3; PI548573) were identical. The GmPhyA3 alleles of Moshidou Gong 503 (ft3/ft3; JP27603) and L62-667 (e3/e3; PI547716) showed weak or complete loss of function, respectively. High red/far-red (R/FR) long-day conditions enhanced the effects of the E3/FT3 alleles in various genetic backgrounds. Moreover, a mutant line harboring the nonfunctional GmPhyA3 flowered earlier than the original Bay (E3/E3; PI553043) under similar conditions. These results suggest that the variation in phytochrome A may contribute to the complex systems of soybean flowering response and geographic adaptation. PMID:19474204

  13. E3 ubiquitin ligases as drug targets and prognostic biomarkers in melanoma

    Directory of Open Access Journals (Sweden)

    Kristina Bielskienė

    2015-01-01

    E3 ligases are of interest as drug targets for their ability to regulate proteins stability and functions. Compared to the general proteasome inhibitor bortezomib, which blocks the entire protein degradation, drugs that target a particular E3 ligase are expected to have better selectivity with less associated toxicity. Components of different E3 ligases complexes (FBW7, MDM2, RBX1/ROC1, RBX2/ROC2, cullins and many others are known as oncogenes or tumor suppressors in melanomagenesis. These proteins participate in regulation of different cellular pathways and such important proteins in cancer development as p53 and Notch. In this review we summarized published data on the role of known E3 ligases in the development of melanoma and discuss the inhibitors of E3 ligases as a novel approach for the treatment of malignant melanomas.

  14. The strength compass

    DEFF Research Database (Denmark)

    Ledertoug, Mette Marie

    of agreement/disagreement. Also the child/teacher is asked whether the actual strength is important and if he or she has the possibilities to apply the strength in the school. In a PhDproject ‘Strengths-based Learning - Children’s Character Strengths as Means to their Learning Potential’ 750 Danish children......Individual paper presentation: The ‘Strength Compass’. The results of a PhDresearch project among schoolchildren (age 6-16) identifying VIAstrengths concerning age, gender, mother-tongue-langue and possible child psychiatric diagnosis. Strengths-based interventions in schools have a theoretical...... Psychological Publishing Company. ‘The Strength Compass’ is a computer/Ipad based qualitative tool to identify the strengths of a child by a self-survey or a teacher’s survey. It is designed as a visual analogue scale with a statement of the strength in which the child/teacher may declare the degree...

  15. A novel NR2E3 gene mutation in autosomal recessive retinitis pigmentosa with cystic maculopathy

    OpenAIRE

    Mahajan, D.; Votruba, Marcela

    2017-01-01

    NR2E3 is a gene that encodes for photoreceptor cell specific nuclear receptor, which is involved in cone proliferation. The splice site mutation 119-2A>C in NR2E3 (15q23) has been previously reported to underlie recessive enhanced cone S sensitivity syndrome, clumped pigmentary retinal degeneration, Goldman-Favre syndrome and also autosomal dominant and autosomal recessive retinitis pigmentosa (RP). However, the mutation c 571 + 2 T > C in NR2E3 has not been previously reported with retinal d...

  16. Causal strength induction from time series data.

    Science.gov (United States)

    Soo, Kevin W; Rottman, Benjamin M

    2018-04-01

    One challenge when inferring the strength of cause-effect relations from time series data is that the cause and/or effect can exhibit temporal trends. If temporal trends are not accounted for, a learner could infer that a causal relation exists when it does not, or even infer that there is a positive causal relation when the relation is negative, or vice versa. We propose that learners use a simple heuristic to control for temporal trends-that they focus not on the states of the cause and effect at a given instant, but on how the cause and effect change from one observation to the next, which we call transitions. Six experiments were conducted to understand how people infer causal strength from time series data. We found that participants indeed use transitions in addition to states, which helps them to reach more accurate causal judgments (Experiments 1A and 1B). Participants use transitions more when the stimuli are presented in a naturalistic visual format than a numerical format (Experiment 2), and the effect of transitions is not driven by primacy or recency effects (Experiment 3). Finally, we found that participants primarily use the direction in which variables change rather than the magnitude of the change for estimating causal strength (Experiments 4 and 5). Collectively, these studies provide evidence that people often use a simple yet effective heuristic for inferring causal strength from time series data. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  17. First results with the general equilibrium model GEM-E3 Switzerland

    International Nuclear Information System (INIS)

    Bahn, O.; Frei, C.

    2000-01-01

    The GEM-E3 model has been implemented and applied for Switzerland. It has been in particular used to assess an ecological tax reform in Switzerland. Results of this analysis are presented here. (author)

  18. Scaling of cross-sections for asymmetric (e,3e) process on helium ...

    Indian Academy of Sciences (India)

    , India ... (e, 3e) process; five-fold differential cross-section; scaling; helium isoelec- tronic ions. ... ration and experimental control of the target and the intensity related problems make the measurements extremely difficult. The scaling laws of ...

  19. Redefining E-3 Core Competencies for Dominant Battlespace Knowledge in Future Combat Operations

    National Research Council Canada - National Science Library

    Kirkendall, David A

    2005-01-01

    .... The study focuses on how E-3 training is driven by the maintenance of a set of battle management core competencies rooted in the basics of aircraft tactical fluid control force accountability and aerial refueling...

  20. E3 Success Story - Whirlpool Trains Staff on Lean and Green Advantage

    Science.gov (United States)

    Whirlpool Corporation invited Green Suppliers Network representatives to its Monterrey facility to provide training on the Lean and Green Advantage. The project sought to expand E3 initiatives to every part of the company's operations.

  1. E3 Success Story - Advancing Performance in Sustainability and Workforce Development

    Science.gov (United States)

    E3: North Carolina advances performance in sustainability and workforce development strategies for the state's manufacturers. The initiative helps communities and manufacturers address energy and sustainability challenges by leveraging expertise.

  2. A study of the profile of the E3 electron trap in GaAs

    Energy Technology Data Exchange (ETDEWEB)

    Kourkoutas, C.D. (TEI Athens (Greece). Dept. of Physics Chemistry and Material Technology); Kovacs, B.; Szentpali, B.; Somogyi, K. (Research Inst. for Technical Physics, Budapest (Hungary)); Euthymiou, P.C. (Athens Univ. (Greece)); Giakoumakis, G.E. (Ioannina Univ. (Greece). Dept. of Physics)

    1994-01-01

    Electron irradiation at room temperature introduces in GaAs a donor type electronic state Tx at 0.18 eV, which is associated with the E3 electron trap. The presence of Tx is observed at depths d > 1.5 [mu]m, which correspond to the limits of the depletion region under the highest applied reverse bias voltage, while the E3 trap concentration drops off into the same region. (author).

  3. A study of the profile of the E3 electron trap in GaAs

    International Nuclear Information System (INIS)

    Kourkoutas, C.D.; Euthymiou, P.C.; Giakoumakis, G.E.

    1994-01-01

    Electron irradiation at room temperature introduces in GaAs a donor type electronic state Tx at 0.18 eV, which is associated with the E3 electron trap. The presence of Tx is observed at depths d > 1.5 μm, which correspond to the limits of the depletion region under the highest applied reverse bias voltage, while the E3 trap concentration drops off into the same region. (author)

  4. Molecular structure and spectral properties of ethyl 3-quinolinecarboxylate (E3Q) and [Ag(E3Q)2(TCA)] complex (TCA = Trichloroacetate)

    Science.gov (United States)

    Soliman, Saied M.; Kassem, Taher S.; Badr, Ahmed M. A.; Abou Youssef, Morsy A.; Assem, Rania

    2014-09-01

    A new [Ag(E3Q)2(TCA)] complex; (E3Q = Ethyl 3-quinolinecarboxylate and TCA = Trichloroacetate) has been synthesized and characterized using elemental analysis, FTIR, NMR and mass spectroscopy. The molecular geometry and spectroscopic properties of the complex as well as the free ligand have been calculated using the hybrid B3LYP method. The calculations predicted a distorted tetrahedral arrangement around Ag(I) ion. The vibrational spectra of the studied compounds have been assigned using potential energy distribution (PED). TD-DFT method was used to predict the electronic absorption spectra. The most intense absorption band showed a bathochromic shift and lowering of intensity in case of the complex (233.7 nm, f = 0.5604) compared to E3Q (λmax = 228.0 nm, f = 0.9072). The calculated 1H NMR chemical shifts using GIAO method showed good correlations with the experimental data. The computed dipole moment, polarizability and HOMO-LUMO energy gap were used to predict the nonlinear optical (NLO) properties. It is found that Ag(I) enhances the NLO activity. The natural bond orbital (NBO) analyses were used to elucidate the intramolecular charge transfer interactions causing stabilization for the investigated systems.

  5. Transitional Justice

    DEFF Research Database (Denmark)

    Gissel, Line Engbo

    This presentation builds on an earlier published article, 'Contemporary Transitional Justice: Normalising a Politics of Exception'. It argues that the field of transitional justice has undergone a shift in conceptualisation and hence practice. Transitional justice is presently understood to be th...... to be the provision of ordinary criminal justice in contexts of exceptional political transition.......This presentation builds on an earlier published article, 'Contemporary Transitional Justice: Normalising a Politics of Exception'. It argues that the field of transitional justice has undergone a shift in conceptualisation and hence practice. Transitional justice is presently understood...

  6. Strengths-based Learning

    DEFF Research Database (Denmark)

    Ledertoug, Mette Marie

    -being. The Ph.D.-project in Strength-based learning took place in a Danish school with 750 pupils age 6-16 and a similar school was functioning as a control group. The presentation will focus on both the aware-explore-apply processes and the practical implications for the schools involved, and on measurable......Strength-based learning - Children͛s Character Strengths as Means to their Learning Potential͛ is a Ph.D.-project aiming to create a strength-based mindset in school settings and at the same time introducing strength-based interventions as specific tools to improve both learning and well...

  7. Give Me Strength.

    Institute of Scientific and Technical Information of China (English)

    维拉

    1996-01-01

    Mort had an absolutely terrible day at the office.Everythingthat could go wrong did go wrong.As he walked home he could beheard muttering strange words to himself:“Oh,give me strength,give me strength.”Mort isn’t asking for the kind of strength thatbuilds strong muscles:he’s asking for the courage or ability to

  8. Case study of the interdisciplinary integration in an IST-E3 project

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik

    2002-01-01

    Case study of a specific IST-E3 project funded by the EU commissions 5th framework program. The case study highlights the difficulties in integrating different disciplinary approaches and suggests that a more openended research strategy should be applied by the commission.......Case study of a specific IST-E3 project funded by the EU commissions 5th framework program. The case study highlights the difficulties in integrating different disciplinary approaches and suggests that a more openended research strategy should be applied by the commission....

  9. Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

    Directory of Open Access Journals (Sweden)

    Wouter Boomsma

    2016-02-01

    Full Text Available The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important. E3 ubiquitin-protein ligases mediate substrate ubiquitination by bringing together the substrate with an E2 ubiquitin-conjugating enzyme, which transfers ubiquitin to the substrate. For misfolded proteins, substrate recognition is generally delegated to molecular chaperones that subsequently interact with specific E3 ligases. An important exception is San1, a yeast E3 ligase. San1 harbors extensive regions of intrinsic disorder, which provide both conformational flexibility and sites for direct recognition of misfolded targets of vastly different conformations. So far, no mammalian ortholog of San1 is known, nor is it clear whether other E3 ligases utilize disordered regions for substrate recognition. Here, we conduct a bioinformatics analysis to examine >600 human and S. cerevisiae E3 ligases to identify enzymes that are similar to San1 in terms of function and/or mechanism of substrate recognition. An initial sequence-based database search was found to detect candidates primarily based on the homology of their ordered regions, and did not capture the unique disorder patterns that encode the functional mechanism of San1. However, by searching specifically for key features of the San1 sequence, such as long regions of intrinsic disorder embedded with short stretches predicted to be suitable for substrate interaction, we identified several E3 ligases with these characteristics. Our initial analysis revealed that another remarkable trait of San1 is shared with several candidate E3 ligases: long stretches of complete lysine suppression, which in San1 limits auto-ubiquitination. We encode these characteristic features into a San1 similarity-score, and present a set of proteins that are plausible candidates as San1 counterparts in humans. In conclusion, our work

  10. Monitoring of high-risk pregnancies using E3 and HPL

    Energy Technology Data Exchange (ETDEWEB)

    Bieglmayer, Ch; Spona, J

    1981-01-01

    Routine determinations of HPL and E3 together with other clinical and laboratory checks offer usable information on the state of pregnancy and assist the doctor in taking decisions on the use of therapeutical measures. The anamnesis, the presence of placental insufficiency of EPH-gestosis are important indications for monitoring the pregnancy using HPL and E3. A commercial RIA apparatus (Centria 2) allowing the determination of HPL in a mere hour was compared with our established laboratory method. In 140 determinations, the correlation was r=0.75. Considering its capacity and method, the instrument seems to be more suitable for a small specialized laboratory.

  11. Supporting Transition

    Science.gov (United States)

    Qureshi, Asima; Petrucco, James

    2018-01-01

    Meadowbrook Primary School has explored the use of The Teacher Assessment in Primary Science (TAPS) to support transition, initially for transfer to secondary school and now for transition from Early Years Foundation Stage (EYFS) into Key Stage 1 (ages 5-7). This article will consider an example of a secondary transition project and discuss the…

  12. Correlation and relativistic effects for the 4f-nl and 5p-nl multipole transitions in Er-like tungsten

    International Nuclear Information System (INIS)

    Safronova, U. I.; Safronova, A. S.

    2011-01-01

    Wavelengths, transition rates, and line strengths are calculated for the multipole (E1, M1, E2, M2, E3, and M3) transitions between the excited [Cd]4f 13 5p 6 nl, [Cd]4f 14 5p 5 nl configurations and the ground [Cd]4f 14 5p 6 state in Er-like W 6+ ion ([Cd]=[Kr]4d 10 5s 2 ). In particular, the relativistic many-body perturbation theory (RMBPT), including the Breit interaction, is used to evaluate energies and transition rates for multipole transitions in this hole-particle system. This method is based on the relativistic many-body perturbation theory that agrees with multiconfiguration Dirac-Fock (MCDF) calculations in lowest order, and includes all second-order correlation corrections and corrections from negative-energy states. The calculations start from a [Cd]4f 14 5p 6 Dirac-Fock (DF) potential. First-order perturbation theory is used to obtain intermediate-coupling coefficients, and second-order RMBPT is used to determine the multipole matrix elements needed for calculations of other atomic properties such as line strengths and transition rates. In addition, core multipole polarizability is evaluated in random-phase and DF approximations. The comparison with available data is demonstrated.

  13. Anisotropic Concrete Compressive Strength

    DEFF Research Database (Denmark)

    Gustenhoff Hansen, Søren; Jørgensen, Henrik Brøner; Hoang, Linh Cao

    2017-01-01

    When the load carrying capacity of existing concrete structures is (re-)assessed it is often based on compressive strength of cores drilled out from the structure. Existing studies show that the core compressive strength is anisotropic; i.e. it depends on whether the cores are drilled parallel...

  14. High strength ferritic alloy

    International Nuclear Information System (INIS)

    1977-01-01

    A high strength ferritic steel is specified in which the major alloying elements are chromium and molybdenum, with smaller quantities of niobium, vanadium, silicon, manganese and carbon. The maximum swelling is specified for various irradiation conditions. Rupture strength is also specified. (U.K.)

  15. Photon strength functions

    International Nuclear Information System (INIS)

    Bergqvist, I.

    1976-01-01

    Methods for extracting photon strength functions are briefly discussed. We follow the Brink-Axel approach to relate the strength functions to the giant resonances observed in photonuclear work and summarize the available data on the E1, E2 and M1 resonances. Some experimental and theoretical problems are outlined. (author)

  16. Interviewing to Understand Strengths

    Science.gov (United States)

    Hass, Michael R.

    2018-01-01

    Interviewing clients about their strengths is an important part of developing a complete understanding of their lives and has several advantages over simply focusing on problems and pathology. Prerequisites for skillfully interviewing for strengths include the communication skills that emerge from a stance of not knowing, developing a vocabulary…

  17. Decay of the isoscalar 1(h/2π)ω giant E3 resonance in 92Mo

    International Nuclear Information System (INIS)

    Klein, R.A.

    1984-01-01

    By means of the Heidelberg tandem-post accelerator combination the decay of the isoscalar 1 (h/2π)ω giant E3 resonance (LEOR) in 92 Mo was studied by (α, α', γ) coincidence measurements. At an incident energy of 50.4 MeV of the α particles the scattered helium nuclei were spectroscoped by eight semiconductor detectors in a maximum of the L=3 angular distribution. The γ quanta emitted coincidently by the excited target nuclei were detected in three high-resolution Ge diodes. Because of the good resolution both in the alpha and in the gamma branch for about 30 states in the excitation energy range of 1-7 MeV branching ratios for the gamma decay could be measured. For 16 of these levels lifetimes were determined by the Doppler-shift attenuation method. Starting from the determined branching ratios and typical lifetimes (40-90 fs) for 3 - states in the excitation-energy range of the LEOR (5-10 MeV) an earlier reported strong ground-state decay (8%) of the LEOR can be excluded. Rather the LEOR decays so as it is expected by the model of the statistical decay namely dominantly to low-lying 3 - , 4 - , and above all 5 - levels. A likewise reported strong E1-decay of the LEOR to the 2 + 1 state in 90 Zr which is implicated in the framework of a collective model in connection with the E3 ground-state transitions can in 92 Mo also not be confirmed. In spite of the strongly collective nature of the first 2 + state in 92 Mo an increased LEOR decay to this level was not observed. Against that in the LEOR region ground-state transitions of 1 - states with isoscalar nature were spectroscoped. The observation of these levels is also reproduced by performed RPA calculations. A parallel measurement on 90 Zr confirms the results of this thesis. (orig./HSI) [de

  18. Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases

    DEFF Research Database (Denmark)

    Boomsma, Wouter Krogh; Nielsen, Sofie Vincents; Lindorff-Larsen, Kresten

    2016-01-01

    conduct a bioinformatics analysis to examine >600 human and S. cerevisiae E3 ligases to identify enzymes that are similar to San1 in terms of function and/or mechanism of substrate recognition. An initial sequence-based database search was found to detect candidates primarily based on the homology...

  19. NMR characterization of foldedness for the production of E3 RING domains

    NARCIS (Netherlands)

    Huang, A.; de Jong, R.N.; Folkers, G.E.; Boelens, R.

    2010-01-01

    We summarize the use of NMR spectroscopy in the production and the screening of stability and foldedness of protein domains, and apply it to the RING domains of E3 ubiquitin-ligases. RING domains are involved in specific interactions with E2 ubiquitin-conjugating enzymes and thus play an essential

  20. Ophthalmic epidemiology in Europe : the "European Eye Epidemiology" (E3) consortium

    NARCIS (Netherlands)

    Delcourt, Cecile; Korobelnik, Jean-Francois; Buitendijk, Gabrielle H. S.; Foster, Paul J.; Hammond, Christopher J.; Piermarocchi, Stefano; Peto, Tunde; Jansonius, Nomdo; Mirshahi, Alireza; Hogg, Ruth E.; Bretillon, Lionel; Topouzis, Fotis; Deak, Gabor; Grauslund, Jakob; Broe, Rebecca; Souied, Eric H.; Creuzot-Garcher, Catherine; Sahel, Jose; Daien, Vincent; Lehtimaki, Terho; Hense, Hans-Werner; Prokofyeva, Elena; Oexle, Konrad; Rahi, Jugnoo S.; Cumberland, Phillippa M.; Schmitz-Valckenberg, Steffen; Fauser, Sascha; Bertelsen, Geir; Hoyng, Carel; Bergen, Arthur; Silva, Rufino; Wolf, Sebastian; Lotery, Andrew; Chakravarthy, Usha; Fletcher, Astrid; Klaver, Caroline C. W.

    The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000

  1. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.

    Science.gov (United States)

    Brown, Nicholas G; VanderLinden, Ryan; Watson, Edmond R; Weissmann, Florian; Ordureau, Alban; Wu, Kuen-Phon; Zhang, Wei; Yu, Shanshan; Mercredi, Peter Y; Harrison, Joseph S; Davidson, Iain F; Qiao, Renping; Lu, Ying; Dube, Prakash; Brunner, Michael R; Grace, Christy R R; Miller, Darcie J; Haselbach, David; Jarvis, Marc A; Yamaguchi, Masaya; Yanishevski, David; Petzold, Georg; Sidhu, Sachdev S; Kuhlman, Brian; Kirschner, Marc W; Harper, J Wade; Peters, Jan-Michael; Stark, Holger; Schulman, Brenda A

    2016-06-02

    Protein ubiquitination involves E1, E2, and E3 trienzyme cascades. E2 and RING E3 enzymes often collaborate to first prime a substrate with a single ubiquitin (UB) and then achieve different forms of polyubiquitination: multiubiquitination of several sites and elongation of linkage-specific UB chains. Here, cryo-EM and biochemistry show that the human E3 anaphase-promoting complex/cyclosome (APC/C) and its two partner E2s, UBE2C (aka UBCH10) and UBE2S, adopt specialized catalytic architectures for these two distinct forms of polyubiquitination. The APC/C RING constrains UBE2C proximal to a substrate and simultaneously binds a substrate-linked UB to drive processive multiubiquitination. Alternatively, during UB chain elongation, the RING does not bind UBE2S but rather lures an evolving substrate-linked UB to UBE2S positioned through a cullin interaction to generate a Lys11-linked chain. Our findings define mechanisms of APC/C regulation, and establish principles by which specialized E3-E2-substrate-UB architectures control different forms of polyubiquitination. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Characterizations of Space Curves According to Bishop Darboux Vector in Euclidean 3-Space E3

    OpenAIRE

    Huseyin KOCAYIGIT; Ali OZDEMIR

    2014-01-01

    In this paper, we obtained some characterizations of space curves according to Bihop frame in Euclidean 3-space E3 by using Laplacian operator and Levi-Civita connection. Furthermore, we gave the general differential equations which characterize the space curves according to the Bishop Darboux vector and the normal Bishop Darboux vector.

  3. Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.

    Directory of Open Access Journals (Sweden)

    Rakesh Kumar Singh

    Full Text Available Core histone proteins are essential for packaging the genomic DNA into chromatin in all eukaryotes. Since multiple genes encode these histone proteins, there is potential for generating more histones than what is required for chromatin assembly. The positively charged histones have a very high affinity for negatively charged molecules such as DNA, and any excess of histone proteins results in deleterious effects on genomic stability and cell viability. Hence, histone levels are known to be tightly regulated via transcriptional, posttranscriptional and posttranslational mechanisms. We have previously elucidated the posttranslational regulation of histone protein levels by the ubiquitin-proteasome pathway involving the E2 ubiquitin conjugating enzymes Ubc4/5 and the HECT (Homologous to E6-AP C-Terminus domain containing E3 ligase Tom1 in the budding yeast. Here we report the identification of four additional E3 ligases containing the RING (Really Interesting New Gene finger domains that are involved in the ubiquitylation and subsequent degradation of excess histones in yeast. These E3 ligases are Pep5, Snt2 as well as two previously uncharacterized Open Reading Frames (ORFs YKR017C and YDR266C that we have named Hel1 and Hel2 (for Histone E3 Ligases respectively. Mutants lacking these E3 ligases are sensitive to histone overexpression as they fail to degrade excess histones and accumulate high levels of endogenous histones on histone chaperones. Co-immunoprecipitation assays showed that these E3 ligases interact with the major E2 enzyme Ubc4 that is involved in the degradation related ubiquitylation of histones. Using mutagenesis we further demonstrate that the RING domains of Hel1, Hel2 and Snt2 are required for histone regulation. Lastly, mutants corresponding to Hel1, Hel2 and Pep5 are sensitive to replication inhibitors. Overall, our results highlight the importance of posttranslational histone regulatory mechanisms that employ multiple E3

  4. 34 CFR 300.43 - Transition services.

    Science.gov (United States)

    2010-07-01

    ..., including postsecondary education, vocational education, integrated employment (including supported...; (2) Is based on the individual child's needs, taking into account the child's strengths, preferences..., acquisition of daily living skills and provision of a functional vocational evaluation. (b) Transition...

  5. Pathfinding the Flight Advanced Stirling Convertor Design with the ASC-E3

    Science.gov (United States)

    Wong, Wayne A.; Wilson, Kyle; Smith, Eddie; Collins, Josh

    2012-01-01

    The Advanced Stirling Convertor (ASC) was initially developed by Sunpower, Inc. under contract to NASA Glenn Research Center (GRC) as a technology development project. The ASC technology fulfills NASA's need for high efficiency power convertors for future Radioisotope Power Systems (RPS). Early successful technology demonstrations between 2003 to 2005 eventually led to the expansion of the project including the decision in 2006 to use the ASC technology on the Advanced Stirling Radioisotope Generator (ASRG). Sunpower has delivered 22 ASC convertors of progressively mature designs to date to GRC. Currently, Sunpower with support from GRC, Lockheed Martin Space System Company (LMSSC), and the Department of Energy (DOE) is developing the flight ASC-F in parallel with the ASC-E3 pathfinders. Sunpower will deliver four pairs of ASC-E3 convertors to GRC which will be used for extended operation reliability assessment, independent validation and verification testing, system interaction tests, and to support LMSSC controller verification. The ASC-E3 and -F convertors are being built to the same design and processing documentation and the same product specification. The initial two pairs of ASC-E3 are built before the flight units and will validate design and processing changes prior to implementation on the ASC-F flight convertors. This paper provides a summary on development of the ASC technology and the status of the ASC-E3 build and how they serve the vital pathfinder role ahead of the flight build for ASRG. The ASRG is part of two of the three candidate missions being considered for selection for the Discovery 12 mission.

  6. Transition radiation and transition scattering

    International Nuclear Information System (INIS)

    Ginzburg, V.L.

    1982-01-01

    Transition radiation is a process of a rather general character. It occurs when some source, which does not have a proper frequency (for example, a charge) moves at a constant velocity in an inhomogeneous and (or) nonstationary medium or near such a medium. The simplest type of transition radiation takes place when a charge crosses a boundary between two media (the role of one of the media may be played by vacuum). In the case of periodic variation of the medium, transition radiation possesses some specific features (resonance transition radiation or transition scattering). Transition scattering occurs, in particular, when a permittivity wave falls onto an nonmoving (fixed) charge. Transition scattering is closely connected with transition bremsstrahlung radiation. All these transition processes are essential for plasma physics. Transition radiation and transition scattering have analogues outside the framework of electrodynamics (like in the case of Vavilov-Cherenkov radiation). In the present report the corresponding range of phenomena is elucidated, as far as possible, in a generally physical aspect. (Auth.)

  7. ACCURATE LABORATORY WAVELENGTHS OF THE e 3 Σ-(ν' = 5) - X 1 Σ+(ν'' = 0) BAND OF 12C16O

    International Nuclear Information System (INIS)

    Dickenson, G. D.; Nortje, A. C.; Steenkamp, C. M.; Rohwer, E. G.; Du Plessis, A.

    2010-01-01

    The forbidden singlet-triplet transitions of carbon monoxide (CO) are important in the interpretation of vacuum ultraviolet interstellar absorption spectra and in particular for the measurement of large CO column densities. Twenty rovibronic lines of the e 3 Σ - (ν' = 5) - X 1 Σ + (ν'' = 0) band of 12 C 16 O for which laboratory wavelengths were previously unavailable were identified in laser-induced fluorescence excitation spectra. Wavelengths were assigned to five rovibronic transitions to an average accuracy of 0.0028 A. A further 15 lines could not be fully resolved and average wavelengths were measured for these groups of closely spaced lines. A wavelength difference of 0.011 ± 0.0028 A between the measured wavelengths and the calculated wavelengths in the atlas of Eidelsberg and Rostas demonstrates the need for more experimental data on CO.

  8. Accurate Laboratory Wavelengths of the e 3 Σ-(ν' = 5) - X 1 Σ+(ν'' = 0) Band of 12C16O

    Science.gov (United States)

    Dickenson, G. D.; Nortje, A. C.; Steenkamp, C. M.; Rohwer, E. G.; Du Plessis, A.

    2010-05-01

    The forbidden singlet-triplet transitions of carbon monoxide (CO) are important in the interpretation of vacuum ultraviolet interstellar absorption spectra and in particular for the measurement of large CO column densities. Twenty rovibronic lines of the e 3Σ-(ν' = 5) - X 1Σ+(ν'' = 0) band of 12 C 16O for which laboratory wavelengths were previously unavailable were identified in laser-induced fluorescence excitation spectra. Wavelengths were assigned to five rovibronic transitions to an average accuracy of 0.0028 Å. A further 15 lines could not be fully resolved and average wavelengths were measured for these groups of closely spaced lines. A wavelength difference of 0.011 ± 0.0028 Å between the measured wavelengths and the calculated wavelengths in the atlas of Eidelsberg & Rostas demonstrates the need for more experimental data on CO.

  9. E3 protein of bovine coronavirus is a receptor-destroying enzyme with acetylesterase activity

    International Nuclear Information System (INIS)

    Vlasak, R.; Luytjes, W.; Leider, J.; Spaan, W.; Palese, P.

    1988-01-01

    In addition to members of the Orthomyxoviridae and Paramyxoviridae, several coronaviruses have been shown to possess receptor-destroying activities. Purified bovine coronavirus (BCV) preparations have an esterase activity which inactivates O-acetylsialic acid-containing receptors on erythrocytes. Diisopropyl fluorophosphate (DFP) completely inhibits this receptor-destroying activity of BCV, suggesting that the viral enzyme is a serine esterase. Treatment of purified BCV with [ 3 H]DFP and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the proteins revealed that the esterase/receptor-destroying activity of BCV is associated with the E3 protein was specifically phosphorylated. This finding suggests that the esterase/receptor-destroying activity of BCV is associated with the E3 protein. Furthermore, treatment of BCV with DFP dramatically reduced its infectivity in a plaque assay. It is assumed that the esterase activity of BCV is required in an early step of virus replication, possible during virus entry or uncoating

  10. Ghosts of Milky Way's past: the globular cluster ESO 37-1 (E 3)

    Science.gov (United States)

    de la Fuente Marcos, R.; de la Fuente Marcos, C.; Moni Bidin, C.; Ortolani, S.; Carraro, G.

    2015-09-01

    Context. In the Milky Way, most globular clusters are highly conspicuous objects that were found centuries ago. However, a few dozen of them are faint, sparsely populated systems that were identified largely during the second half of the past century. One of the faintest is ESO 37-1 (E 3) and as such it remains poorly studied, with no spectroscopic observations published so far although it was discovered in 1976. Aims: We investigate the globular cluster E 3 in an attempt to better constrain its fundamental parameters. Spectroscopy of stars in the field of E 3 is shown here for the first time. Methods: Deep, precise VI CCD photometry of E 3 down to V ~ 26 mag is presented and analysed. Low-resolution, medium signal-to-noise ratio spectra of nine candidate members are studied to derive radial velocity and metallicity. Proper motions from the UCAC4 catalogue are used to explore the kinematics of the bright members of E 3. Results: Isochrone fitting indicates that E 3 is probably very old, with an age of about 13 Gyr; its distance from the Sun is nearly 10 kpc. It is also somewhat metal rich with [Fe/H] = -0.7. Regarding its kinematics, our tentative estimate for the proper motions is (μα cosδ,μδ) = (-7.0 ± 0.8, 3.5 ± 0.3) mas yr-1 (or a tangential velocity of 382 ± 79 km s-1) and for the radial velocity 45 ± 5 km s-1 in the solar rest frame. Conclusions: E 3 is one of the most intriguing globular clusters in the Galaxy. Having an old age and being metal rich is clearly a peculiar combination, only seen in a handful of objects like the far more conspicuous NGC 104 (47 Tucanae). In addition, its low luminosity and sparse population make it a unique template for the study of the final evolutionary phases in the life of a star cluster. Unfortunately, E 3 is among the most elusive and challenging known globular clusters because field contamination severely hampers spectroscopic studies. This research note is based on observations made with the ESO VLT at the

  11. Light Distribution in the E3 and E4 Scintillation Counters of the ATLAS Tile Calorimeter

    CERN Document Server

    Hsu, Catherine

    2013-01-01

    The Tile Calorimeter (TileCal) of the ATLAS experiment is an important component of the ATLAS calorimetry because they play a crucial role in the search for new particles. The E3 and E4 are crack scintillators of TileCal that extend into the gap region between the EM barrel and EM endcaps. They thus sample the energy of the EM showers produced by particles interacting with the dead material in the EM calorimeters and with the inner detector cables. This project focuses on the study of the light collection uniformity in the E3 and E4 scintillating tiles using low energy electrons as the ionising particles. It is important to have uniform light response in the tiles because it would ensure a good energy resolution for the dead region. However, many factors affect the uniform light collection within the scintillating tiles.

  12. E3 protein of bovine coronavirus is a receptor-destroying enzyme with acetylesterase activity

    Energy Technology Data Exchange (ETDEWEB)

    Vlasak, R.; Luytjes, W.; Leider, J.; Spaan, W.; Palese, P.

    1988-12-01

    In addition to members of the Orthomyxoviridae and Paramyxoviridae, several coronaviruses have been shown to possess receptor-destroying activities. Purified bovine coronavirus (BCV) preparations have an esterase activity which inactivates O-acetylsialic acid-containing receptors on erythrocytes. Diisopropyl fluorophosphate (DFP) completely inhibits this receptor-destroying activity of BCV, suggesting that the viral enzyme is a serine esterase. Treatment of purified BCV with (/sup 3/H)DFP and subsequent sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the proteins revealed that the esterase/receptor-destroying activity of BCV is associated with the E3 protein was specifically phosphorylated. This finding suggests that the esterase/receptor-destroying activity of BCV is associated with the E3 protein. Furthermore, treatment of BCV with DFP dramatically reduced its infectivity in a plaque assay. It is assumed that the esterase activity of BCV is required in an early step of virus replication, possible during virus entry or uncoating.

  13. Establishment of a Wheat Cell-Free Synthesized Protein Array Containing 250 Human and Mouse E3 Ubiquitin Ligases to Identify Novel Interaction between E3 Ligases and Substrate Proteins.

    Directory of Open Access Journals (Sweden)

    Hirotaka Takahashi

    Full Text Available Ubiquitination is a key post-translational modification in the regulation of numerous biological processes in eukaryotes. The primary roles of ubiquitination are thought to be the triggering of protein degradation and the regulation of signal transduction. During protein ubiquitination, substrate specificity is mainly determined by E3 ubiquitin ligase (E3. Although more than 600 genes in the human genome encode E3, the E3s of many target proteins remain unidentified owing to E3 diversity and the instability of ubiquitinated proteins in cell. We demonstrate herein a novel biochemical analysis for the identification of E3s targeting specific proteins. Using wheat cell-free protein synthesis system, a protein array containing 227 human and 23 mouse recombinant E3s was synthesized. To establish the high-throughput binding assay using AlphaScreen technology, we selected MDM2 and p53 as the model combination of E3 and its target protein. The AlphaScreen assay specifically detected the binding of p53 and MDM2 in a crude translation mixture. Then, a comprehensive binding assay using the E3 protein array was performed. Eleven of the E3s showed high binding activity, including four previously reported E3s (e.g., MDM2, MDM4, and WWP1 targeting p53. This result demonstrated the reliability of the assay. Another interactors, RNF6 and DZIP3-which there have been no report to bind p53-were found to ubiquitinate p53 in vitro. Further analysis showed that RNF6 decreased the amount of p53 in H1299 cells in E3 activity-dependent manner. These results suggest the possibility that the RNF6 ubiquitinates and degrades p53 in cells. The novel in vitro screening system established herein is a powerful tool for finding novel E3s of a target protein.

  14. Lunar Penetrating Radar onboard the Chang'e-3 mission

    International Nuclear Information System (INIS)

    Fang Guang-You; Zhou Bin; Ji Yi-Cai; Zhang Qun-Ying; Shen Shao-Xiang; Li Yu-Xi; Guan Hong-Fei; Tang Chuan-Jun; Gao Yun-Ze; Lu Wei; Ye Sheng-Bo; Han Hai-Dong; Zheng Jin; Wang Shu-Zhi

    2014-01-01

    Lunar Penetrating Radar (LPR) is one of the important scientific instruments onboard the Chang'e-3 spacecraft. Its scientific goals are the mapping of lunar regolith and detection of subsurface geologic structures. This paper describes the goals of the mission, as well as the basic principles, design, composition and achievements of the LPR. Finally, experiments on a glacier and the lunar surface are analyzed

  15. ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response.

    Science.gov (United States)

    Malakhova, Oxana A; Zhang, Dong-Er

    2008-04-04

    Interferons regulate diverse immune functions through the transcriptional activation of hundreds of genes involved in anti-viral responses. The interferon-inducible ubiquitin-like protein ISG15 is expressed in cells in response to a variety of stress conditions like viral or bacterial infection and is present in its free form or is conjugated to cellular proteins. In addition, protein ubiquitination plays a regulatory role in the immune system. Many viruses modulate the ubiquitin (Ub) pathway to alter cellular signaling and the antiviral response. Ubiquitination of retroviral group-specific antigen precursors and matrix proteins of the Ebola, vesicular stomatitis, and rabies viruses by Nedd4 family HECT domain E3 ligases is an important step in facilitating viral release. We found that Nedd4 is negatively regulated by ISG15. Free ISG15 specifically bound to Nedd4 and blocked its interaction with Ub-E2 molecules, thus preventing further Ub transfer from E2 to E3. Furthermore, overexpression of ISG15 diminished the ability of Nedd4 to ubiquitinate viral matrix proteins and led to a decrease in the release of Ebola VP40 virus-like particles from the cells. These results point to a mechanistically novel function of ISG15 in the enhancement of the innate anti-viral response through specific inhibition of Nedd4 Ub-E3 activity. To our knowledge, this is the first example of a Ub-like protein with the ability to interfere with Ub-E2 and E3 interaction to inhibit protein ubiquitination.

  16. Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast.

    Science.gov (United States)

    Nakatsukasa, Kunio; Okumura, Fumihiko; Kamura, Takumi

    2015-01-01

    Eukaryotic organisms use diverse mechanisms to control metabolic rates in response to changes in the internal and/or external environment. Fine metabolic control is a highly responsive, energy-saving process that is mediated by allosteric inhibition/activation and/or reversible modification of preexisting metabolic enzymes. In contrast, coarse metabolic control is a relatively long-term and expensive process that involves modulating the level of metabolic enzymes. Coarse metabolic control can be achieved through the degradation of metabolic enzymes by the ubiquitin-proteasome system (UPS), in which substrates are specifically ubiquitinated by an E3 ubiquitin ligase and targeted for proteasomal degradation. Here, we review select multi-protein E3 ligase complexes that directly regulate metabolic enzymes in Saccharomyces cerevisiae. The first part of the review focuses on the endoplasmic reticulum (ER) membrane-associated Hrd1 and Doa10 E3 ligase complexes. In addition to their primary roles in the ER-associated degradation pathway that eliminates misfolded proteins, recent quantitative proteomic analyses identified native substrates of Hrd1 and Doa10 in the sterol synthesis pathway. The second part focuses on the SCF (Skp1-Cul1-F-box protein) complex, an abundant prototypical multi-protein E3 ligase complex. While the best-known roles of the SCF complex are in the regulation of the cell cycle and transcription, accumulating evidence indicates that the SCF complex also modulates carbon metabolism pathways. The increasing number of metabolic enzymes whose stability is directly regulated by the UPS underscores the importance of the proteolytic regulation of metabolic processes for the acclimation of cells to environmental changes.

  17. A bacterial E3 ubiquitin ligase targets a host protein kinase to disrupt plant immunity.

    Science.gov (United States)

    Rosebrock, Tracy R; Zeng, Lirong; Brady, Jennifer J; Abramovitch, Robert B; Xiao, Fangming; Martin, Gregory B

    2007-07-19

    Many bacterial pathogens of plants and animals use a type III secretion system to deliver diverse virulence-associated 'effector' proteins into the host cell. The mechanisms by which these effectors act are mostly unknown; however, they often promote disease by suppressing host immunity. One type III effector, AvrPtoB, expressed by the plant pathogen Pseudomonas syringae pv. tomato, has a carboxy-terminal domain that is an E3 ubiquitin ligase. Deletion of this domain allows an amino-terminal region of AvrPtoB (AvrPtoB(1-387)) to be detected by certain tomato varieties leading to immunity-associated programmed cell death. Here we show that a host kinase, Fen, physically interacts with AvrPtoB(1-387 )and is responsible for activating the plant immune response. The AvrPtoB E3 ligase specifically ubiquitinates Fen and promotes its degradation in a proteasome-dependent manner. This degradation leads to disease susceptibility in Fen-expressing tomato lines. Various wild species of tomato were found to exhibit immunity in response to AvrPtoB(1-387 )and not to full-length AvrPtoB. Thus, by acquiring an E3 ligase domain, AvrPtoB has thwarted a highly conserved host resistance mechanism.

  18. HSV-1 ICP0: An E3 Ubiquitin Ligase That Counteracts Host Intrinsic and Innate Immunity

    Directory of Open Access Journals (Sweden)

    Mirna Perusina Lanfranca

    2014-05-01

    Full Text Available The herpes simplex virus type 1 (HSV-1 encoded E3 ubiquitin ligase, infected cell protein 0 (ICP0, is required for efficient lytic viral replication and regulates the switch between the lytic and latent states of HSV-1. As an E3 ubiquitin ligase, ICP0 directs the proteasomal degradation of several cellular targets, allowing the virus to counteract different cellular intrinsic and innate immune responses. In this review, we will focus on how ICP0’s E3 ubiquitin ligase activity inactivates the host intrinsic defenses, such as nuclear domain 10 (ND10, SUMO, and the DNA damage response to HSV-1 infection. In addition, we will examine ICP0’s capacity to impair the activation of interferon (innate regulatory mediators that include IFI16 (IFN γ-inducible protein 16, MyD88 (myeloid differentiation factor 88, and Mal (MyD88 adaptor-like protein. We will also consider how ICP0 allows HSV-1 to evade activation of the NF-κB (nuclear factor kappa B inflammatory signaling pathway. Finally, ICP0’s paradoxical relationship with USP7 (ubiquitin specific protease 7 and its roles in intrinsic and innate immune responses to HSV-1 infection will be discussed.

  19. Construction of new operation interface for the LABIHS simulator using the ELIPSE E3 studio software

    Energy Technology Data Exchange (ETDEWEB)

    Augusto, Silas C.; Oliveira, Mauro V., E-mail: silas@ien.gov.b, E-mail: mvitor@ien.gov.b [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    The Human-System Interface Laboratory (LABIHS), located at the Instituto de Engenharia Nuclear (IEN), has a compact simulator that simulate the processes of a pressurized water reactor nuclear power plant of 930 MWe of power. This simulator is composed by a HP-UX workstation computer, where the simulation software runs, and a set of computer stations, that represent an advanced control room, where the simulator is operated by software control panels that represent several systems of the simulated nuclear power plant. The current HSIs for the LABIHS simulator was built using iLog software tool. The development of new human-system interfaces (HSIs) for the simulator is one of the research fields of LABIHS. This paper presents the screen components development process for a new HSI for the LABIHS simulator, using the software Elipse{sup TM} E3 Studio. These new components developed using the E3 Studio are similar to the ones used in the current simulator interface. The article shows some comparisons between the component and screen development with Elipse{sup TM} E3 Studio processes and using iLog Studio. (author)

  20. Construction of new operation interface for the LABIHS simulator using the ELIPSE E3 studio software

    International Nuclear Information System (INIS)

    Augusto, Silas C.; Oliveira, Mauro V.

    2011-01-01

    The Human-System Interface Laboratory (LABIHS), located at the Instituto de Engenharia Nuclear (IEN), has a compact simulator that simulate the processes of a pressurized water reactor nuclear power plant of 930 MWe of power. This simulator is composed by a HP-UX workstation computer, where the simulation software runs, and a set of computer stations, that represent an advanced control room, where the simulator is operated by software control panels that represent several systems of the simulated nuclear power plant. The current HSIs for the LABIHS simulator was built using iLog software tool. The development of new human-system interfaces (HSIs) for the simulator is one of the research fields of LABIHS. This paper presents the screen components development process for a new HSI for the LABIHS simulator, using the software Elipse TM E3 Studio. These new components developed using the E3 Studio are similar to the ones used in the current simulator interface. The article shows some comparisons between the component and screen development with Elipse TM E3 Studio processes and using iLog Studio. (author)

  1. Identification of Arabidopsis MYB56 as a novel substrate for CRL3(BPM) E3 ligases.

    Science.gov (United States)

    Chen, Liyuan; Bernhardt, Anne; Lee, JooHyun; Hellmann, Hanjo

    2015-02-01

    Controlled stability of proteins is a highly efficient mechanism to direct diverse processes in living cells. A key regulatory system for protein stability is given by the ubiquitin proteasome pathway, which uses E3 ligases to mark specific proteins for degradation. In this work, MYB56 is identified as a novel target of a CULLIN3 (CUL3)-based E3 ligase. Its stability depends on the presence of MATH-BTB/POZ (BPM) proteins, which function as substrate adaptors to the E3 ligase. Genetic studies have indicated that MYB56 is a negative regulator of flowering, while BPMs positively affect this developmental program. The interaction between BPMs and MYB56 occurs at the promoter of FLOWERING LOCUS T (FT), a key regulator in initiating flowering in Arabidopsis, and results in instability of MYB56. Overall the work establishes MYB transcription factors as substrates of BPM proteins, and provides novel information on components that participate in controlling flowering time in plants. Copyright © 2015 The Author. Published by Elsevier Inc. All rights reserved.

  2. Identification of Arabidopsis MYB56 as a novel substrate for CRL3BPM E3 ligases.

    Science.gov (United States)

    Chen, Liyuan; Bernhardt, Anne; Lee, JooHyun; Hellmann, Hanjo

    2014-10-24

    Controlled stability of proteins is a highly efficient mechanism to direct diverse processes in living cells. A key regulatory system for protein stability is given by the ubiquitin proteasome pathway, which uses E3 ligases to mark specific proteins for degradation. In this work MYB56 is identified as a novel target of a CULLIN3 (CUL3)-based E3 ligase. Its stability depends on the presence of MATH-BTB/POZ (BPM) proteins, which function as substrate adaptors to the E3 ligase. Genetic studies pointed out that MYB56 is a negative regulator of flowering, while BPMs positively affect this developmental program. The interaction between BPMs and MYB56 occurs at the promoter of FLOWERING LOCUS T (FT), a key regulator in initiating flowering in Arabidopsis, and results in instability of MYB56. Overall the work establishes MYB transcription factors as substrates of BPM proteins, and provides novel information on components that participate in controlling the flowering time point in plants. © The Author 2014. Published by the Molecular Plant Shanghai Editorial Office in association with Oxford University Press on behalf of CSPB and IPPE, SIBS, CAS.

  3. GEM-E3: A computable general equilibrium model applied for Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Bahn, O. [Paul Scherrer Inst., CH-5232 Villigen PSI (Switzerland); Frei, C. [Ecole Polytechnique Federale de Lausanne (EPFL) and Paul Scherrer Inst. (Switzerland)

    2000-01-01

    The objectives of the European Research Project GEM-E3-ELITE, funded by the European Commission and coordinated by the Centre for European Economic Research (Germany), were to further develop the general equilibrium model GEM-E3 (Capros et al., 1995, 1997) and to conduct policy analysis through case studies. GEM-E3 is an applied general equilibrium model that analyses the macro-economy and its interaction with the energy system and the environment through the balancing of energy supply and demand, atmospheric emissions and pollution control, together with the fulfillment of overall equilibrium conditions. PSI's research objectives within GEM-E3-ELITE were to implement and apply GEM-E3 for Switzerland. The first objective required in particular the development of a Swiss database for each of GEM-E3 modules (economic module and environmental module). For the second objective, strategies to reduce CO{sub 2} emissions were evaluated for Switzerland. In order to develop the economic, PSI collaborated with the Laboratory of Applied Economics (LEA) of the University of Geneva and the Laboratory of Energy Systems (LASEN) of the Federal Institute of Technology in Lausanne (EPFL). The Swiss Federal Statistical Office (SFSO) and the Institute for Business Cycle Research (KOF) of the Swiss Federal Institute of Technology (ETH Zurich) contributed also data. The Swiss environmental database consists mainly of an Energy Balance Table and of an Emission Coefficients Table. Both were designed using national and international official statistics. The Emission Coefficients Table is furthermore based on know-how of the PSI GaBE Project. Using GEM-E3 Switzerland, two strategies to reduce the Swiss CO{sub 2} emissions were evaluated: a carbon tax ('tax only' strategy), and the combination of a carbon tax with the buying of CO{sub 2} emission permits ('permits and tax' strategy). In the first strategy, Switzerland would impose the necessary carbon tax to achieve

  4. GEM-E3: A computable general equilibrium model applied for Switzerland

    International Nuclear Information System (INIS)

    Bahn, O.; Frei, C.

    2000-01-01

    The objectives of the European Research Project GEM-E3-ELITE, funded by the European Commission and coordinated by the Centre for European Economic Research (Germany), were to further develop the general equilibrium model GEM-E3 (Capros et al., 1995, 1997) and to conduct policy analysis through case studies. GEM-E3 is an applied general equilibrium model that analyses the macro-economy and its interaction with the energy system and the environment through the balancing of energy supply and demand, atmospheric emissions and pollution control, together with the fulfillment of overall equilibrium conditions. PSI's research objectives within GEM-E3-ELITE were to implement and apply GEM-E3 for Switzerland. The first objective required in particular the development of a Swiss database for each of GEM-E3 modules (economic module and environmental module). For the second objective, strategies to reduce CO 2 emissions were evaluated for Switzerland. In order to develop the economic, PSI collaborated with the Laboratory of Applied Economics (LEA) of the University of Geneva and the Laboratory of Energy Systems (LASEN) of the Federal Institute of Technology in Lausanne (EPFL). The Swiss Federal Statistical Office (SFSO) and the Institute for Business Cycle Research (KOF) of the Swiss Federal Institute of Technology (ETH Zurich) contributed also data. The Swiss environmental database consists mainly of an Energy Balance Table and of an Emission Coefficients Table. Both were designed using national and international official statistics. The Emission Coefficients Table is furthermore based on know-how of the PSI GaBE Project. Using GEM-E3 Switzerland, two strategies to reduce the Swiss CO 2 emissions were evaluated: a carbon tax ('tax only' strategy), and the combination of a carbon tax with the buying of CO 2 emission permits ('permits and tax' strategy). In the first strategy, Switzerland would impose the necessary carbon tax to achieve the reduction target, and use the tax

  5. Cyclotron transitions of bound ions

    Science.gov (United States)

    Bezchastnov, Victor G.; Pavlov, George G.

    2017-06-01

    A charged particle in a magnetic field possesses discrete energy levels associated with particle rotation around the field lines. The radiative transitions between these levels are the well-known cyclotron transitions. We show that a bound complex of particles with a nonzero net charge displays analogous transitions between the states of confined motion of the entire complex in the field. The latter bound-ion cyclotron transitions are affected by a coupling between the collective and internal motions of the complex and, as a result, differ from the transitions of a "reference" bare ion with the same mass and charge. We analyze the cyclotron transitions for complex ions by including the coupling within a rigorous quantum approach. Particular attention is paid to comparison of the transition energies and oscillator strengths to those of the bare ion. Selection rules based on integrals of collective motion are derived for the bound-ion cyclotron transitions analytically, and the perturbation and coupled-channel approaches are developed to study the transitions quantitatively. Representative examples are considered and discussed for positive and negative atomic and cluster ions.

  6. Systematics of strength function sum rules

    Directory of Open Access Journals (Sweden)

    Calvin W. Johnson

    2015-11-01

    Full Text Available Sum rules provide useful insights into transition strength functions and are often expressed as expectation values of an operator. In this letter I demonstrate that non-energy-weighted transition sum rules have strong secular dependences on the energy of the initial state. Such non-trivial systematics have consequences: the simplification suggested by the generalized Brink–Axel hypothesis, for example, does not hold for most cases, though it weakly holds in at least some cases for electric dipole transitions. Furthermore, I show the systematics can be understood through spectral distribution theory, calculated via traces of operators and of products of operators. Seen through this lens, violation of the generalized Brink–Axel hypothesis is unsurprising: one expects sum rules to evolve with excitation energy. Furthermore, to lowest order the slope of the secular evolution can be traced to a component of the Hamiltonian being positive (repulsive or negative (attractive.

  7. Phase transitions

    CERN Document Server

    Sole, Ricard V; Solé, Ricard V; Solé, Ricard V; Sol, Ricard V; Solé, Ricard V

    2011-01-01

    Phase transitions--changes between different states of organization in a complex system--have long helped to explain physics concepts, such as why water freezes into a solid or boils to become a gas. How might phase transitions shed light on important problems in biological and ecological complex systems? Exploring the origins and implications of sudden changes in nature and society, Phase Transitions examines different dynamical behaviors in a broad range of complex systems. Using a compelling set of examples, from gene networks and ant colonies to human language and the degradation of diverse ecosystems, the book illustrates the power of simple models to reveal how phase transitions occur. Introductory chapters provide the critical concepts and the simplest mathematical techniques required to study phase transitions. In a series of example-driven chapters, Ricard Solé shows how such concepts and techniques can be applied to the analysis and prediction of complex system behavior, including the origins of ...

  8. Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

    Science.gov (United States)

    Hodson, Charlotte; Purkiss, Andrew; Miles, Jennifer Anne; Walden, Helen

    2014-01-01

    Summary The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrate choice and the modification type. The molecular details of generic E3-E2 interactions are well established. Nevertheless, the determinants of selective, specific E3-E2 recognition are not understood. There are ∼40 E2s and ∼600 E3s giving rise to a possible ∼24,000 E3-E2 pairs. Using the Fanconi Anemia pathway exclusive E3-E2 pair, FANCL-Ube2T, we report the atomic structure of the FANCL RING-Ube2T complex, revealing a specific and extensive network of additional electrostatic and hydrophobic interactions. Furthermore, we show that these specific interactions are required for selection of Ube2T over other E2s by FANCL. PMID:24389026

  9. Strength of Fibrous Composites

    CERN Document Server

    Huang, Zheng-Ming

    2012-01-01

    "Strength of Fibrous Composites" addresses evaluation of the strength of a fibrous composite by using its constituent material properties and its fiber architecture parameters. Having gone through the book, a reader is able to predict the progressive failure behavior and ultimate strength of a fibrous laminate subjected to an arbitrary load condition in terms of the constituent fiber and matrix properties, as well as fiber geometric parameters. The book is useful to researchers and engineers working on design and analysis for composite materials. Dr. Zheng-Ming Huang is a professor at the School of Aerospace Engineering & Applied Mechanics, Tongji University, China. Mr. Ye-Xin Zhou is a PhD candidate at the Department of Mechanical Engineering, the University of Hong Kong, China.

  10. High strength alloys

    Science.gov (United States)

    Maziasz, Phillip James [Oak Ridge, TN; Shingledecker, John Paul [Knoxville, TN; Santella, Michael Leonard [Knoxville, TN; Schneibel, Joachim Hugo [Knoxville, TN; Sikka, Vinod Kumar [Oak Ridge, TN; Vinegar, Harold J [Bellaire, TX; John, Randy Carl [Houston, TX; Kim, Dong Sub [Sugar Land, TX

    2010-08-31

    High strength metal alloys are described herein. At least one composition of a metal alloy includes chromium, nickel, copper, manganese, silicon, niobium, tungsten and iron. System, methods, and heaters that include the high strength metal alloys are described herein. At least one heater system may include a canister at least partially made from material containing at least one of the metal alloys. At least one system for heating a subterranean formation may include a tubular that is at least partially made from a material containing at least one of the metal alloys.

  11. Hand grip strength

    DEFF Research Database (Denmark)

    Frederiksen, Henrik; Gaist, David; Petersen, Hans Christian

    2002-01-01

    in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known......-55%). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively, were found in this study. Hence grip strength is a suitable phenotype for identifying genetic variants of importance to mid...

  12. The Processing and Analysis of Lunar Penetrating Radar Channel-1 Data from Chang'E-3

    Directory of Open Access Journals (Sweden)

    Gao Yun-ze

    2015-10-01

    Full Text Available Lunar Penetrating Radar (LPR, which is one of the most important science payloads onboard the Chang'E-3 (CE-3 rover, is used to obtain electromagnetic image less than 100 m beneath the lunar surface. This paper describes the system composition and working mechanism of the LPR and presents a detailed analysis of its data. We investigated special signal-processing methods and present the result of channel-1 data. The result shows that the effective echo occurs at depths greater than 100 m. Moreover, an unusual reflection exists at depth of 40 m, which may be the boundary of two geological units beneath the lunar surface.

  13. Subsurface structures in the northern Mare Imbrium measured by Chang'E-3 and SELENE

    Science.gov (United States)

    Kumamoto, A.; Ishiyama, K.; Feng, J.

    2016-12-01

    Subsurface structures in the northern Mare Imbrium measured by Chang'E-3 and SELENE have been compared. In Chang'E-3 mission, subsurface radar sounding at (19.51W, 44.12N) was performed by Lunar Penetrating Radar (LPR) onboard the Yutu rover. The LPR was pulse radar operated at two frequencies: 60 MHz and 500 MHz. During its operation period from December 2013 to January 2014, the LPR observed subsurface echoes along the rover's track with total distance of 114 m. From the observation in 60 MHz, the subsurface echoes from buried regolith layers at depths of 35, 50, 140, 240, and 360 m were reported (Xiao et al., 2015). In SELENE mission, global subsurface radar sounding of the moon was performed by Lunar Radar Sounder (LRS) onboard the SELENE (Kaguya) spacecraft from the polar orbit with an altitude of 100 km. The LRS was chirp radar operated in a frequency range from 4-6 MHz. So the range resolution of LRS was 75 m in vacuum. During operation period from December 2007 to September 2008, subsurface echoes from all areas of the Moon was observed with a lateral resolution of 76 m. From the global observation, the subsurface echoes from the buried regolith layers in the neraside maria including Mare Imbrium at depths of several hundred meters were reported (Ono et al., 2009).In the present study, we focus on SELENE/LRS data obtained at (19.50W, 44.12N) which is the nearest to the Chang'E-3 landing site. While clear and large-scale subsurface reflectors, as found in Ono et al. (2009), are not found in it, we can identify some echo components from the depths of 140 ( 2000 ns), 240 ( 4000 ns), and 360 m ( 6000 ns). Further analyses utilizing high-resolution data from Chang'E-3/LPR and large-scale data from SELENE/LRS, we will be able to determine the thickness and large-scale structures of the buried regolith layers found by the both radars, and discuss their formation processes in volcanic history of Mare Imbrium.

  14. The Processing and Analysis of Lunar Penetrating Radar Channel-1 Data from Chang'E-3

    OpenAIRE

    Gao Yun-ze; Dong Ze-hua; Fang Guang-you; Ji Yi-cai; Zhou Bin

    2015-01-01

    Lunar Penetrating Radar (LPR), which is one of the most important science payloads onboard the Chang'E-3 (CE-3) rover, is used to obtain electromagnetic image less than 100 m beneath the lunar surface. This paper describes the system composition and working mechanism of the LPR and presents a detailed analysis of its data. We investigated special signal-processing methods and present the result of channel-1 data. The result shows that the effective echo occurs at depths greater than 100 m. Mo...

  15. IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases

    DEFF Research Database (Denmark)

    Schmid, Fabian Marc; Schou, Kenneth Bødtker; Vilhelm, Martin Juel

    2018-01-01

    ciliogenesis, and ciliary localization of the receptor is required for its appropriate ligand-mediated activation by PDGF-AA. However, the mechanisms regulating sorting of PDGFRα and feedback inhibition of PDGFRα signaling at the cilium are unknown. Here, we provide evidence that intraflagellar transport...... protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cbl-mediated ubiquitination and internalization of PDGFRα for feedback inhibition of receptor signaling. In wild-type cells treated with PDGF-AA, c-Cbl becomes enriched in the cilium, and the receptor...

  16. Theory of free-bound transitions in channeling radiation

    International Nuclear Information System (INIS)

    Saenz, A.W.; Nagl, A.; Uberall, H.

    1988-01-01

    On the basis of a single-string model, we derive formulas for the transition strengths of free-bound transitions of axially channeled electrons. We illustrate the theory by numerical calculations of these strengths for 3.5-MeV electrons in Si. Experimental evidence for such transitions has been obtained previously [J.U. Andersen et al., Nucl. Instrum. Methods 194, 209 (1982)] and is in good qualitative agreement with our calculations

  17. Transit transparency.

    Science.gov (United States)

    2012-07-01

    Public transit agencies have employed intelligent systems for determining : schedules and routes and for monitoring the real-time location and status of their : vehicle fleets for nearly two decades. But until recently, the data generated by : daily ...

  18. Probe tests microweld strength

    Science.gov (United States)

    1965-01-01

    Probe is developed to test strength of soldered, brazed or microwelded joints. It consists of a spring which may be adjusted to the desired test pressure by means of a threaded probe head, and an indicator lamp. Device may be used for electronic equipment testing.

  19. Coplanar (e, 3e) differential cross-section of He atom

    CERN Document Server

    Choubisa, R; Sud, K K

    2003-01-01

    We present in this paper the results of our calculation of five-fold differential cross-section (FDCS) for (e, 3e) process on He atom in low momentum transfer and high electron impact energy in shake-off mechanism. The formalism has been developed in Born approximation using plane waves. Byron and Joachain as well as Le Sech and correlated BBK-type wave functions respectively for incident and scattered. bound and ejected electrons. The angular distribution of FDCS of our calculation is presented in various modes of coplanar geometry and comparison is made with the available experimental data. We observe that the present calculation is able to reproduce the trend of the experimental data. However, it differs in magnitude from the experiment. The present theory does not predict four-peak structure in summed mutual angle mode for lower excess ejected electron energies. We also discuss the importance of momentum transfer, post-collision interaction (PCI) and ion participation in the (e, 3e) process in constant th...

  20. No Evidence for Multiple Stellar Populations in the Low-mass Galactic Globular Cluster E 3

    Science.gov (United States)

    Salinas, Ricardo; Strader, Jay

    2015-08-01

    Multiple stellar populations are a widespread phenomenon among Galactic globular clusters. Even though the origin of the enriched material from which new generations of stars are produced remains unclear, it is likely that self-enrichment will be feasible only in clusters massive enough to retain this enriched material. We searched for multiple populations in the low mass (M˜ 1.4× {10}4 {M}⊙ ) globular cluster E3, analyzing SOAR/Goodman multi-object spectroscopy centered on the blue cyanogen (CN) absorption features of 23 red giant branch stars. We find that the CN abundance does not present the typical bimodal behavior seen in clusters hosting multistellar populations, but rather a unimodal distribution that indicates the presence of a genuine single stellar population, or a level of enrichment much lower than in clusters that show evidence for two populations from high-resolution spectroscopy. E3 would be the first bona fide Galactic old globular cluster where no sign of self-enrichment is found. Based on observations obtained at the Southern Astrophysical Research (SOAR) Telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the US National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

  1. Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.

    Science.gov (United States)

    Sarkar, Sukumar; Brautigan, David L; Larner, James M

    2017-08-01

    Reducing the levels of the androgen receptor (AR) is one of the most viable approaches to combat castration-resistant prostate cancer. Previously, we observed that proteasomal-dependent degradation of AR in response to 2-methoxyestradiol (2-ME) depends primarily on the E3 ligase C-terminus of HSP70-interacting protein (STUB1/CHIP). Here, 2-ME stimulation activates CHIP by phosphorylation via Aurora kinase A (AURKA). Aurora A kinase inhibitors and RNAi knockdown of Aurora A transcript selectively blocked CHIP phosphorylation and AR degradation. Aurora A kinase is activated by 2-ME in the S-phase as well as during mitosis, and phosphorylates CHIP at S273. Prostate cancer cells expressing an S273A mutant of CHIP have attenuated AR degradation upon 2-ME treatment compared with cells expressing wild-type CHIP, supporting the idea that CHIP phosphorylation by Aurora A activates its E3 ligase activity for the AR. These results reveal a novel 2-ME→Aurora A→CHIP→AR pathway that promotes AR degradation via the proteasome that may offer novel therapeutic opportunities for prostate cancer. Mol Cancer Res; 15(8); 1063-72. ©2017 AACR . ©2017 American Association for Cancer Research.

  2. The MIEL1 E3 Ubiquitin Ligase Negatively Regulates Cuticular Wax Biosynthesis in Arabidopsis Stems.

    Science.gov (United States)

    Lee, Hong Gil; Kim, Juyoung; Suh, Mi Chung; Seo, Pil Joon

    2017-07-01

    Cuticular wax is an important hydrophobic layer that covers the plant aerial surface. Cuticular wax biosynthesis is shaped by multiple layers of regulation. In particular, a pair of R2R3-type MYB transcription factors, MYB96 and MYB30, are known to be the main participants in cuticular wax accumulation. Here, we report that the MYB30-INTERACTING E3 LIGASE 1 (MIEL1) E3 ubiquitin ligase controls the protein stability of the two MYB transcription factors and thereby wax biosynthesis in Arabidopsis. MIEL1-deficient miel1 mutants exhibit increased wax accumulation in stems, with up-regulation of wax biosynthetic genes targeted by MYB96 and MYB30. Genetic analysis reveals that wax accumulation of the miel1 mutant is compromised by myb96 or myb30 mutation, but MYB96 is mainly epistatic to MIEL1, playing a predominant role in cuticular wax deposition. These observations indicate that the MIEL1-MYB96 module is important for balanced cuticular wax biosynthesis in developing inflorescence stems. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  3. Blocking an N-terminal acetylation–dependent protein interaction inhibits an E3 ligase

    Energy Technology Data Exchange (ETDEWEB)

    Scott, Daniel C.; Hammill, Jared T.; Min, Jaeki; Rhee, David Y.; Connelly, Michele; Sviderskiy, Vladislav O.; Bhasin, Deepak; Chen, Yizhe; Ong, Su-Sien; Chai, Sergio C.; Goktug, Asli N.; Huang, Guochang; Monda, Julie K.; Low, Jonathan; Kim, Ho Shin; Paulo, Joao A.; Cannon, Joe R.; Shelat, Anang A.; Chen, Taosheng; Kelsall, Ian R.; Alpi, Arno F.; Pagala, Vishwajeeth; Wang, Xusheng; Peng, Junmin; Singh , Bhuvanesh; Harper, J. Wade; Schulman, Brenda A.; Guy, R. Kip (MSKCC); (Dundee); (SJCH); (Harvard-Med); (MXPL)

    2017-06-05

    N-terminal acetylation is an abundant modification influencing protein functions. Because ~80% of mammalian cytosolic proteins are N-terminally acetylated, this modification is potentially an untapped target for chemical control of their functions. Structural studies have revealed that, like lysine acetylation, N-terminal acetylation converts a positively charged amine into a hydrophobic handle that mediates protein interactions; hence, this modification may be a druggable target. We report the development of chemical probes targeting the N-terminal acetylation–dependent interaction between an E2 conjugating enzyme (UBE2M or UBC12) and DCN1 (DCUN1D1), a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8. The inhibitors are highly selective with respect to other protein acetyl-amide–binding sites, inhibit NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification. Overall, our data demonstrate that N-terminal acetyl-dependent protein interactions are druggable targets and provide insights into targeting multiprotein E2–E3 ligases.

  4. Diagramming Transactive Building Business Cases: Using Principles of e3 Value to Document Valuation Studies

    Energy Technology Data Exchange (ETDEWEB)

    Hammerstrom, Donald J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Makhmalbaf, Atefe [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Marinovici, Maria C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-12-30

    Energy management in buildings is becoming more transactive. Pacific Northwest National Laboratory and the U.S. Department of Energy Building Technologies Office recently defined innovative use cases wherein market-like mechanisms are used to manage energy within buildings, between buildings, and between buildings and third-party entities, such as power utilities. A next step toward defining a set of transactive use cases in the buildings domain is to carefully diagram the corresponding business cases to capture details of transactions among all stakeholders and their economic value propositions. The principles of e3-value diagramming are applied in this report toward creating business value diagrams. These principles are extended to be consistent with Universal Modeling Language use-case diagrams. Example diagrams are presented for a subset of buildings-domain use cases that were introduced in an earlier Pacific Northwest National Laboratory report. The diagrams are intended to clearly represent an understanding of the transactions through which individual entities accumulate value in their respective use cases, and the diagrams should therefore support economic valuation studies. The report reviews some of the foundational principles of e3 value and includes authors’ insights concerning the formulation of these diagrams using Universal Modeling Language as a more systematic modeling approach.

  5. A conserved role for the ARC1 E3 ligase in Brassicaceae self-incompatibility

    Directory of Open Access Journals (Sweden)

    Daphne eGoring

    2014-05-01

    Full Text Available Ubiquitination plays essential roles in the regulation of many processes in plants including pollen rejection in self-incompatible species. In the Brassicaceae (mustard family, self-incompatibility drives the rejection of self-pollen by preventing pollen hydration following pollen contact with the stigmatic surface. Self-pollen is recognized by a ligand-receptor pair: the pollen S-locus Cysteine Rich/S-locus Protein 11 (SCR/SP11 ligand and the pistil S Receptor Kinase (SRK. Following self-pollen contact, the SCR/SP11 ligand on the pollen surface binds to SRK on the pistil surface, and the SRK-activated signaling pathway is initiated. This pathway includes the ARM Repeat Containing 1 (ARC1 protein, a member of the Plant U-box (PUB family of E3 ubiquitin ligases. ARC1 is a functional E3 ligase and is required downstream of SRK for the self-incompatibility response. This mini review highlights our recent progress in establishing ARC1’s conserved role in self-pollen rejection in Brassica and Arabidopsis species and discusses future research directions in this field.

  6. Highly retarded M2 transition in 90Nb

    International Nuclear Information System (INIS)

    Sergeev, V.O.

    2006-01-01

    One studied properties of 2.3 keV transition between 124.67 (4 - ) and 122.37 keV (6 + ) in 90 Nb. The mentioned M2-transition is shown to be retarded by approximately 10 4 times and provided explanations of the mentioned extraordinary high factor of deceleration. One evaluated impurity of E3 possible multipolarity constituent in the mentioned transition (δ 2 [ru

  7. Electromagnetic transition strengths in 75Kr and 79Sr

    International Nuclear Information System (INIS)

    Cardona, M.A.; Filevich, Alberto; Garcia Bermudez, Gerardo; Achterberg, Erhard

    1989-01-01

    Experimental and theoretical studies of nuclear structure in light Kr and Sr isotopes have revealed a region of large quadrupole deformation. In this work, deformation properties of odd-nuclei 75 Kr and 79 Sr have been investigated. For this purpose, lifetime of excited states in both nuclei have been measured by means of the recoil distance Doppler shift technique. These nuclei were populated via the reactions: 54 Fe( 24 Mg,2pn) 75 Kr at 75 MeV and 54 Fe( 28 Si,2pn) 79 Sr at 97 MeV, the beams were provided by the Tandar accelerator. The experimental B(E2) values for these nuclei were well reproduced in the framework of the triaxial-rotor-plus quasiparticle model. In order to fix the parameters of the model a study of neighboring even-even Kr isotopes was performed. The whole N=3 and N=4 oscillator shell was used for the space configuration of the odd particle for negative and positive bands respectively. (Author) [es

  8. Strengths perspective among the homeless adolescents: A systematic review

    Directory of Open Access Journals (Sweden)

    Janmejaya Samal

    2017-01-01

    Full Text Available Background: Earlier, the scholars of family studies have primarily focused on the problems and weaknesses of the families. However, during these days, there is a shift from problems to strength-based perspective. Methodology: Search of literature was carried out through internet-based Google Scholar search engine. Of the 112 titles obtained 21 titles fit the criteria of the study objectives, of which 9 full-text articles were finally selected for the purpose of this review. Results: In this review, nine full-text articles were reviewed. Nine of these researches investigated different facets of strengths perspective among the homeless adolescents. Chronologically, nine of these reviewed studies delineated the following thematic facets of strengths perspective among the homeless adolescents. These include personal strength and informal resources, personal strength in high-risk environment, strengths perspective during the transition of adolescence to adulthood, personal and social strengths that refrained the homeless adolescents form intravenous drug use, resilience and self-esteem, religion as an important strength, “hope” as a way of living among the homeless adolescents, coping strategies of street-involved youth, and usage of internet and social media as an important strength among homeless adolescents. Conclusion: Strengths perspective helps the youth to become a master of their own lives and helps to deal with all the adversities in life.

  9. Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice

    NARCIS (Netherlands)

    Delsing, D.J.; Jukema, J.W.; van de Wiel, M.A.; Emeis, J.; van der Laarse, A.; Havekes, L.M.; Princen, H.M.G.

    2003-01-01

    This study was designed to investigate the potential antiatherosclerotic effects of the calcium antagonist amlodipine as compared with the HMG-CoA reductase inhibitor atorvastatin and the combination of both in ApoE*3-Leiden transgenic mice. Four groups of 15 ApoE*3-Leiden mice were put on a

  10. Measurement of the E1/E3 phase in 226Ra

    Science.gov (United States)

    Amzal, N.; Butler, P. A.; Hawcroft, D.; Hammond, N. J.; Herzberg, R.-D.; Jones, G. D.; Scholey, C.; Stezowski, O.; Czosnyka, T.; Iwanicki, J.; Napiorkowski, P. J.; Julin, R.; Mach, H.; Cerderka¨Ll, J.; Fraile, L. M.; Fynbo, H. O. U.; Isolde Collaboration

    2004-04-01

    We report experimental attempts to determine the sign of the electric dipole moment (relative to the electric octupole moment) in the octupole deformed nucleus 226Ra. Sensitivity to this quantity is observed in the measured yields of γ-ray transitions following very low energy Coulomb excitation.

  11. Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.

    Directory of Open Access Journals (Sweden)

    Raphael Roduit

    Full Text Available BACKGROUND: NR2E3 (PNR is an orphan nuclear receptor essential for proper photoreceptor determination and differentiation. In humans, mutations in NR2E3 have been associated with the recessively inherited enhanced short wavelength sensitive (S- cone syndrome (ESCS and, more recently, with autosomal dominant retinitis pigmentosa (adRP. NR2E3 acts as a suppressor of the cone generation program in late mitotic retinal progenitor cells. In adult rod photoreceptors, NR2E3 represses cone-specific gene expression and acts in concert with the transcription factors CRX and NRL to activate rod-specific genes. NR2E3 and CRX have been shown to physically interact in vitro through their respective DNA-binding domains (DBD. The DBD also contributes to homo- and heterodimerization of nuclear receptors. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed NR2E3 homodimerization and NR2E3/CRX complex formation in an in vivo situation by Bioluminescence Resonance Energy Transfer (BRET(2. NR2E3 wild-type protein formed homodimers in transiently transfected HEK293T cells. NR2E3 homodimerization was impaired in presence of disease-causing mutations in the DBD, except for the p.R76Q and p.R104W mutant proteins. Strikingly, the adRP-linked p.G56R mutant protein interacted with CRX with a similar efficiency to that of NR2E3 wild-type and p.R311Q proteins. In contrast, all other NR2E3 DBD-mutant proteins did not interact with CRX. The p.G56R mutant protein was also more effective in abolishing the potentiation of rhodospin gene transactivation by the NR2E3 wild-type protein. In addition, the p.G56R mutant enhanced the transrepression of the M- and S-opsin promoter, while all other NR2E3 DBD-mutants did not. CONCLUSIONS/SIGNIFICANCE: These results suggest different disease mechanisms in adRP- and ESCS-patients carrying NR2E3 mutations. Titration of CRX by the p.G56R mutant protein acting as a repressor in trans may account for the severe clinical phenotype in adRP patients.

  12. Monopole transitions in hot nuclei

    International Nuclear Information System (INIS)

    Sujkowski, Z.

    1994-01-01

    Monopole transitions can be a signature of shape changing in a hot, pulsating nucleus (the low energy E0 mode) and/or a measure of the compressibility of finite nuclei (GMR, the breathing mode). Experimental information pertaining to GMR is reviewed. Recipes for deducing the incompressibility modules for infinite nuclear matter from data on GMR are discussed. Astrophysical implications are outlined. The first attempts at locating the GMR strength in moderately hot nuclei are described. Prospects for improving the experimental techniques to make an observation of this strength in selected nuclei unambiguous are discussed. (author). 46 refs, 8 figs

  13. Monopole transitions in hot nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Sujkowski, Z. [Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland)

    1994-12-31

    Monopole transitions can be a signature of shape changing in a hot, pulsating nucleus (the low energy E0 mode) and/or a measure of the compressibility of finite nuclei (GMR, the breathing mode). Experimental information pertaining to GMR is reviewed. Recipes for deducing the incompressibility modules for infinite nuclear matter from data on GMR are discussed. Astrophysical implications are outlined. The first attempts at locating the GMR strength in moderately hot nuclei are described. Prospects for improving the experimental techniques to make an observation of this strength in selected nuclei unambiguous are discussed. (author). 46 refs, 8 figs.

  14. Structural analysis of lunar subsurface with Chang'E-3 lunar penetrating radar

    Science.gov (United States)

    Lai, Jialong; Xu, Yi; Zhang, Xiaoping; Tang, Zesheng

    2016-01-01

    Geological structure of the subsurface of the Moon provides valuable information on lunar evolution. Recently, Chang'E-3 has utilized lunar penetrating radar (LPR), which is equipped on the lunar rover named as Yutu, to detect the lunar geological structure in Northern Imbrium (44.1260N, 19.5014W) for the first time. As an in situ detector, Chang'E-3 LPR has relative higher horizontal and vertical resolution and less clutter impact compared to spaceborne radars and earth-based radars. In this work, we analyze the LPR data at 500 MHz transmission frequency to obtain the shallow subsurface structure of the landing area of Chang'E-3 in Mare Imbrium. Filter method and amplitude recovery algorithms are utilized to alleviate the adverse effects of environment and system noises and compensate the amplitude losses during signal propagation. Based on the processed radar image, we observe numerous diffraction hyperbolae, which may be caused by discrete reflectors beneath the lunar surface. Hyperbolae fitting method is utilized to reverse the average dielectric constant to certain depth (ε bar). Overall, the estimated ε bar increases with the depth and ε bar could be classified into three categories. Average ε bar of each category is 2.47, 3.40 and 6.16, respectively. Because of the large gap between the values of ε bar of neighboring categories, we speculate a three-layered structure of the shallow surface of LPR exploration region. One possible geological picture of the speculated three-layered structure is presented as follows. The top layer is weathered layer of ejecta blanket with its average thickness and bound on error is 0.95±0.02 m. The second layer is the ejecta blanket of the nearby impact crater, and the corresponding average thickness is about 2.30±0.07 m, which is in good agreement with the two primary models of ejecta blanket thickness as a function of distance from the crater center. The third layer is regarded as a mixture of stones and soil. The

  15. Structural Analysis of Lunar Subsurface with Chang'E 3 Lunar Penetrating Radar

    Science.gov (United States)

    Xu, Yi; Lai, Jialong; Tang, Zesheng

    2015-04-01

    Geological structure of the subsurface of the Moon provides valuable information for our understanding of lunar evolution. Recently, Chang'E 3 has utilized lunar penetrating radar (LPR), which is equipped on the lunar rover named as Yutu, to detect the lunar geological structure in Northern Imbrium (44.1260N, 19.5014W) for the first time. As an in-situ detector, Chang'E 3 LPR has higher horizontal and vertical resolution and less clutter impact compared to spaceborne radars such as Chandrayaan-1 and Kaguya. In this work, we analyze the LPR data at 500 MHz transmission frequency to obtain the shallow subsurface structure of the landing area of Chang'E 3 in Mare Imbrium. First, filter method and amplitude recover algorithms are introduced for data processing to alleviate the adverse effects of environment and system noises and compensate the amplitude losses during signal propagation. Next, based on the processed LPR data, we present the methods to determine the interfaces between layers. A three-layered structure of the shallow surface of the Moon has been observed. The corresponding real part of relative dielectric constant is inverted with deconvolution method. The average dielectric constants of the surface, second and third layer is 2.8, 3.2 and 3.6, respectively. The phenomenon that the average dielectric constant increases with the depth is consistent with prior art. With the obtained dielectric constants, the thickness of each layer can be calculated. One possible geological picture of the observed three-layered structure is presented as follows. The top layer is lunar regolith with its thickness ranging from 0.59 m to 0.9 m. The second layer is the ejecta blanket of the nearby impact crater, and the corresponding thickness is between 3.6m to 3.9m, which is in good agreement with the model of ejecta blanket thickness (height) as a function of distance from the crater center proposed by Melosh in 1989. The third layer is regarded as early lunar regolith with 4

  16. Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa.

    Science.gov (United States)

    Pepper, Ian J; Van Sciver, Robert E; Tang, Amy H

    2017-08-07

    The RAS signaling pathway is a pivotal developmental pathway that controls many fundamental biological processes including cell proliferation, differentiation, movement and apoptosis. Drosophila Seven-IN-Absentia (SINA) is a ubiquitin E3 ligase that is the most downstream signaling "gatekeeper" whose biological activity is essential for proper RAS signal transduction. Vertebrate SINA homologs (SIAHs) share a high degree of amino acid identity with that of Drosophila SINA. SINA/SIAH is the most conserved signaling component in the canonical EGFR/RAS/RAF/MAPK signal transduction pathway. Vertebrate SIAH1, 2, and 3 are the three orthologs to invertebrate SINA protein. SINA and SIAH1 orthologs are found in all major taxa of metazoans. These proteins have four conserved functional domains, known as RING (Really Interesting New Gene), SZF (SIAH-type zinc finger), SBS (substrate binding site) and DIMER (Dimerization). In addition to the siah1 gene, most vertebrates encode two additional siah genes (siah2 and siah3) in their genomes. Vertebrate SIAH2 has a highly divergent and extended N-terminal sequence, while its RING, SZF, SBS and DIMER domains maintain high amino acid identity/similarity to that of SIAH1. But unlike vertebrate SIAH1 and SIAH2, SIAH3 lacks a functional RING domain, suggesting that SIAH3 may be an inactive E3 ligase. The SIAH3 subtree exhibits a high degree of amino acid divergence when compared to the SIAH1 and SIAH2 subtrees. We find that SIAH1 and SIAH2 are expressed in all human epithelial cell lines examined thus far, while SIAH3 is only expressed in a limited subset of cancer cell lines. Through phylogenetic analyses of metazoan SINA and SIAH E3 ligases, we identified many invariant and divergent amino acid residues, as well as the evolutionarily conserved functional motifs in this medically relevant gene family. Our phylomedicinal study of this unique metazoan SINA/SIAH protein family has provided invaluable evolution-based support towards future

  17. Redox Buffer Strength

    Science.gov (United States)

    de Levie, Robert

    1999-04-01

    The proper functioning of enzymes in bodily fluids requires that the pH be maintained within rather narrow limits. The first line of defense against large pH fluctuations in such fluids is the passive control provided by the presence of pH buffers. The ability of pH buffers to stabilize the pH is indicated by the buffer value b introduced in 1922 by van Slyke. It is equally important for many enzymes that the redox potential is kept within a narrow range. In that case, stability of the potential is most readily achieved with a redox buffer. In this communication we define the redox buffer strength by analogy with acid-base buffer strength.

  18. Global economics/energy/environmental (E3) modeling of long-term nuclear energy futures

    International Nuclear Information System (INIS)

    Krakowski, R.A.; Davidson, J.W.; Bathke, C.G.; Arthur, E.D.; Wagner, R.L. Jr.

    1997-01-01

    A global energy, economics, environment (E 3 ) model has been adopted and modified with a simplified, but comprehensive and multi-regional, nuclear energy module. Using this model, consistent nuclear energy scenarios are constructed. A spectrum of future is examined at two levels in a hierarchy of scenario attributes in which drivers are either external or internal to nuclear energy. Impacts of a range of nuclear fuel-cycle scenarios are reflected back to the higher-level scenario attributes. An emphasis is placed on nuclear materials inventories (in magnitude, location, and form) and their contribution to the long-term sustainability of nuclear energy and the future competitiveness of both conventional and advanced nuclear reactors

  19. Design and Experimental Verification of Chang'E-3 Moon-night Survival Device for APXS

    Science.gov (United States)

    Deng-yi, Chen; Jian, Wu; Yi-ming, Hu; Jin, Chang; Yi-zhong, Gong; Ming-sheng, Cai; Huan-yu, Wang; Jia-yu, Zhang; Xing-zhu, Cui; Jin-zhou, Wang

    2016-07-01

    The Active Particle X-ray Spectrometer (APXS) is one of the 4 scientific payloads of Chang'E-3 (CE-3) Lunar Rover, of which the scientific object is to identify the elements of lunar soil and rock samples by a carried radioactive source to trigger and detect the characteristic X-ray from them. According to the extreme temperature environment of the APXS and under the restriction of limited resources, this paper presents the design and analysis of the moon-night survival device RHU (radioisotope heating unit) for the APXS, and describes the corresponding environmental tests on its structure dynamics and moon-night survival. Finally, its reinstallation on the launch tower and the preliminary result of its on-orbit operation are introduced.

  20. Data processing and initial results of Chang'e-3 lunar penetrating radar

    Science.gov (United States)

    Su, Yan; Fang, Guang-You; Feng, Jian-Qing; Xing, Shu-Guo; Ji, Yi-Cai; Zhou, Bin; Gao, Yun-Ze; Li, Han; Dai, Shun; Xiao, Yuan; Li, Chun-Lai

    2014-12-01

    To improve our understanding of the formation and evolution of the Moon, one of the payloads onboard the Chang'e-3 (CE-3) rover is Lunar Penetrating Radar (LPR). This investigation is the first attempt to explore the lunar subsurface structure by using ground penetrating radar with high resolution. We have probed the subsurface to a depth of several hundred meters using LPR. In-orbit testing, data processing and the preliminary results are presented. These observations have revealed the configuration of regolith where the thickness of regolith varies from about 4 m to 6 m. In addition, one layer of lunar rock, which is about 330 m deep and might have been accumulated during the depositional hiatus of mare basalts, was detected.

  1. Data processing and initial results of Chang'e-3 lunar penetrating radar

    International Nuclear Information System (INIS)

    Su Yan; Feng Jian-Qing; Xing Shu-Guo; Li Han; Dai Shun; Xiao Yuan; Li Chun-Lai; Fang Guang-You; Ji Yi-Cai; Zhou Bin; Gao Yun-Ze

    2014-01-01

    To improve our understanding of the formation and evolution of the Moon, one of the payloads onboard the Chang'e-3 (CE-3) rover is Lunar Penetrating Radar (LPR). This investigation is the first attempt to explore the lunar subsurface structure by using ground penetrating radar with high resolution. We have probed the subsurface to a depth of several hundred meters using LPR. In-orbit testing, data processing and the preliminary results are presented. These observations have revealed the configuration of regolith where the thickness of regolith varies from about 4 m to 6 m. In addition, one layer of lunar rock, which is about 330 m deep and might have been accumulated during the depositional hiatus of mare basalts, was detected

  2. A young multilayered terrane of the northern Mare Imbrium revealed by Chang’E-3 mission

    Science.gov (United States)

    Xiao, Long; Zhu, Peimin; Fang, Guangyou; Xiao, Zhiyong; Zou, Yongliao; Zhao, Jiannan; Zhao, Na; Yuan, Yuefeng; Qiao, Le; Zhang, Xiaoping; Zhang, Hao; Wang, Jiang; Huang, Jun; Huang, Qian; He, Qi; Zhou, Bin; Ji, Yicai; Zhang, Qunying; Shen, Shaoxiang; Li, Yuxi; Gao, Yunze

    2015-03-01

    China’s Chang’E-3 (CE-3) spacecraft touched down on the northern Mare Imbrium of the lunar nearside (340.49°E, 44.12°N), a region not directly sampled before. We report preliminary results with data from the CE-3 lander descent camera and from the Yutu rover’s camera and penetrating radar. After the landing at a young 450-meter crater rim, the Yutu rover drove 114 meters on the ejecta blanket and photographed the rough surface and the excavated boulders. The boulder contains a substantial amount of crystals, which are most likely plagioclase and/or other mafic silicate mineral aggregates similar to terrestrial dolerite. The Lunar Penetrating Radar detection and integrated geological interpretation have identified more than nine subsurface layers, suggesting that this region has experienced complex geological processes since the Imbrian and is compositionally distinct from the Apollo and Luna landing sites.

  3. The preliminary processing and analysis of LPR Channel-2B data from Chang'E-3

    Science.gov (United States)

    Zhao, Na; Zhu, PeiMin; Yang, KeSi; Yuan, YueFeng; Guo, ShiLi

    2014-12-01

    The Lunar Penetrating Radar (LPR) carried by Chang'E-3 has imaged the shallow subsurface of the landing site at the northern Mare Imbrium. The antenna B of the Channel-2 onboard the LPR (LPR Channel-2B) has collected more than 2000 traces of usable raw data. Because of the low resolution and noise of the raw data, only a few shallow geological structures are visible. To improve the resolution and the signal-to-noise ratio of the LPR data, we processed the LPR data including amplitude compensation, filtering, and deconvolution processes. The processing results reveal that the data processing in this study not only improves the signal-to-noise ratio of the LPR Channel-2B data but also makes the geological structures vivid. The processing results will lay the foundation for the subsequent geological interpretation and physical property inversion of lunar materials.

  4. Regolith stratigraphy at the Chang'E-3 landing site as seen by lunar penetrating radar

    Science.gov (United States)

    Fa, Wenzhe; Zhu, Meng-Hua; Liu, Tiantian; Plescia, Jeffrey B.

    2015-12-01

    The Chang'E-3 lunar penetrating radar (LPR) observations at 500 MHz reveal four major stratigraphic zones from the surface to a depth of ~20 m along the survey line: a layered reworked zone (<1 m), an ejecta layer (~2-6 m), a paleoregolith layer (~4-11 m), and the underlying mare basalts. The reworked zone has two to five distinct layers and consists of surface regolith. The paleoregolith buried by the ejecta from a 500 m crater is relatively homogenous and contains only a few rocks. Population of buried rocks increases with depth to ~2 m at first, and then decreases with depth, representing a balance between initial deposition of the ejecta and later turnover of the regolith. Combining with the surface age, the LPR observations indicate a mean accumulation rate of about 5-10 m/Gyr for the surface regolith, which is at least 4-8 times larger than previous estimation.

  5. A young multilayered terrane of the northern Mare Imbrium revealed by Chang'E-3 mission.

    Science.gov (United States)

    Xiao, Long; Zhu, Peimin; Fang, Guangyou; Xiao, Zhiyong; Zou, Yongliao; Zhao, Jiannan; Zhao, Na; Yuan, Yuefeng; Qiao, Le; Zhang, Xiaoping; Zhang, Hao; Wang, Jiang; Huang, Jun; Huang, Qian; He, Qi; Zhou, Bin; Ji, Yicai; Zhang, Qunying; Shen, Shaoxiang; Li, Yuxi; Gao, Yunze

    2015-03-13

    China's Chang'E-3 (CE-3) spacecraft touched down on the northern Mare Imbrium of the lunar nearside (340.49°E, 44.12°N), a region not directly sampled before. We report preliminary results with data from the CE-3 lander descent camera and from the Yutu rover's camera and penetrating radar. After the landing at a young 450-meter crater rim, the Yutu rover drove 114 meters on the ejecta blanket and photographed the rough surface and the excavated boulders. The boulder contains a substantial amount of crystals, which are most likely plagioclase and/or other mafic silicate mineral aggregates similar to terrestrial dolerite. The Lunar Penetrating Radar detection and integrated geological interpretation have identified more than nine subsurface layers, suggesting that this region has experienced complex geological processes since the Imbrian and is compositionally distinct from the Apollo and Luna landing sites. Copyright © 2015, American Association for the Advancement of Science.

  6. Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase: DAWIDZIAK et al.

    Energy Technology Data Exchange (ETDEWEB)

    Dawidziak, Daria M. [Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville Virginia; Sanchez, Jacint G. [Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville Virginia; Wagner, Jonathan M. [Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville Virginia; Ganser-Pornillos, Barbie K. [Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville Virginia; Pornillos, Owen [Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville Virginia

    2017-07-24

    Tripartite motif (TRIM) proteins comprise a large family of RING-type ubiquitin E3 ligases that regulate important biological processes. An emerging general model is that TRIMs form elongated antiparallel coiled-coil dimers that prevent interaction of the two attendant RING domains. The RING domains themselves bind E2 conjugating enzymes as dimers, implying that an active TRIM ligase requires higher-order oligomerization of the basal coiled-coil dimers. Here, we report crystal structures of the TRIM23 RING domain in isolation and in complex with an E2–ubiquitin conjugate. Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation.

  7. RING E3 ligases: key regulatory elements are involved in abiotic stress responses in plants.

    Science.gov (United States)

    Cho, Seok Keun; Ryu, Moon Young; Kim, Jong Hum; Hong, Jeong Soo; Oh, Tae Rin; Kim, Woo Taek; Yang, Seong Wook

    2017-08-01

    Plants are constantly exposed to a variety of abiotic stresses, such as drought, heat, cold, flood, and salinity. To survive under such unfavorable conditions, plants have evolutionarily developed their own resistant-mechanisms. For several decades, many studies have clarified specific stress response pathways of plants through various molecular and genetic studies. In particular, it was recently discovered that ubiquitin proteasome system (UPS), a regulatory mechanism for protein turn over, is greatly involved in the stress responsive pathways. In the UPS, many E3 ligases play key roles in recognizing and tethering poly-ubiquitins on target proteins for subsequent degradation by the 26S proteasome. Here we discuss the roles of RING ligases that have been defined in related to abiotic stress responses in plants. [BMB Reports 2017; 50(8): 393-400].

  8. Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

    Science.gov (United States)

    Ishimoto, Kenji; Hayase, Ayaka; Kumagai, Fumiko; Kawai, Megumi; Okuno, Hiroko; Hino, Nobumasa; Okada, Yoshiaki; Kawamura, Takeshi; Tanaka, Toshiya; Hamakubo, Takao; Sakai, Juro; Kodama, Tatsuhiko; Tachibana, Keisuke; Doi, Takefumi

    2017-06-17

    Lipin-1 has dual functions in the regulation of lipid and energy metabolism according to its subcellular localization, which is tightly controlled. However, it is unclear how Lipin-1 degradation is regulated. Here, we demonstrate that Lipin-1 is degraded through its DSGXXS motif. We show that Lipin-1 interacts with either of two E3 ubiquitin ligases, BTRC or FBXW11, and that this interaction is DSGXXS-dependent and mediates the attachment of polyubiquitin chains. Further, we demonstrate that degradation of Lipin-1 is regulated by BTRC in the cytoplasm and on membranes. These novel insights into the regulation of human Lipin-1 stability will be useful in planning further studies to elucidate its metabolic processes. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.

    Directory of Open Access Journals (Sweden)

    Qiang Wang

    2017-03-01

    Full Text Available The cyclic GMP-AMP synthase (cGAS, upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2'3'-cGAMP, which then binds to stimulator of interferon genes (STING and activates downstream signaling. It remains to be elucidated how the cGAS enzymatic activity is modulated dynamically. Here, we reported that the ER ubiquitin ligase RNF185 interacted with cGAS during HSV-1 infection. Ectopic-expression or knockdown of RNF185 respectively enhanced or impaired the IRF3-responsive gene expression. Mechanistically, RNF185 specifically catalyzed the K27-linked poly-ubiquitination of cGAS, which promoted its enzymatic activity. Additionally, Systemic Lupus Erythematosus (SLE patients displayed elevated expression of RNF185 mRNA. Collectively, this study uncovers RNF185 as the first E3 ubiquitin ligase of cGAS, shedding light on the regulation of cGAS activity in innate immune responses.

  10. Ret Finger Protein: An E3 Ubiquitin Ligase Juxtaposed to the XY Body in Meiosis

    Directory of Open Access Journals (Sweden)

    Isabelle Gillot

    2009-01-01

    Full Text Available During prophase I of male meiosis, the sex chromosomes form a compact structure called XY body that associates with the nuclear membrane of pachytene spermatocytes. Ret Finger Protein is a transcriptional repressor, able to interact with both nuclear matrix-associated proteins and double-stranded DNA. We report the precise and unique localization of Ret Finger Protein in pachytene spermatocytes, in which Ret Finger Protein takes place of lamin B1, between the XY body and the inner nuclear membrane. This localization of Ret Finger Protein does not seem to be associated with O-glycosylation or sumoylation. In addition, we demonstrate that Ret Finger Protein contains an E3 ubiquitin ligase activity. These observations lead to an attractive hypothesis in which Ret Finger Protein would be involved in the positioning and the attachment of XY body to the nuclear lamina of pachytene spermatocytes.

  11. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

    Directory of Open Access Journals (Sweden)

    Pradeep D Uchil

    2008-02-01

    Full Text Available Members of the TRIpartite interaction Motif (TRIM family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse. We identified approximately 20 TRIM proteins that, when transiently expressed in HEK293 cells, affect the entry or release of human immunodeficiency virus 1 (HIV, murine leukemia virus (MLV, or avian leukosis virus (ALV. While TRIM11 and 31 inhibited HIV entry, TRIM11 enhanced N-MLV entry by interfering with Ref1 restriction. Strikingly, many TRIM proteins affected late stages of the viral life cycle. Gene silencing of endogenously expressed TRIM 25, 31, and 62 inhibited viral release indicating that they play an important role at late stages of the viral life cycle. In contrast, downregulation of TRIM11 and 15 enhanced virus release suggesting that these proteins contribute to the endogenous restriction of retroviruses in cells.

  12. Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting.

    Science.gov (United States)

    Kwun, H J; Wendzicki, J A; Shuda, Y; Moore, P S; Chang, Y

    2017-12-07

    The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover. These results provide important insight as to how centrosome number and chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such as MCV sT, which may contribute to Merkel cell carcinogenesis.

  13. [Near infrared distance sensing method for Chang'e-3 alpha particle X-ray spectrometer].

    Science.gov (United States)

    Liang, Xiao-Hua; Wu, Ming-Ye; Wang, Huan-Yu; Peng, Wen-Xi; Zhang, Cheng-Mo; Cui, Xing-Zhu; Wang, Jin-Zhou; Zhang, Jia-Yu; Yang, Jia-Wei; Fan, Rui-Rui; Gao, Min; Liu, Ya-Qing; Zhang, Fei; Dong, Yi-Fan; Guo, Dong-Ya

    2013-05-01

    Alpha particle X-ray spectrometer (APXS) is one of the payloads of Chang'E-3 lunar rover, the scientific objective of which is in-situ observation and off-line analysis of lunar regolith and rock. Distance measurement is one of the important functions for APXS to perform effective detection on the moon. The present paper will first give a brief introduction to APXS, and then analyze the specific requirements and constraints to realize distance measurement, at last present a new near infrared distance sensing algorithm by using the inflection point of response curve. The theoretical analysis and the experiment results verify the feasibility of this algorithm. Although the theoretical analysis shows that this method is not sensitive to the operating temperature and reflectance of the lunar surface, the solar infrared radiant intensity may make photosensor saturation. The solutions are reducing the gain of device and avoiding direct exposure to sun light.

  14. Corium crust strength measurements

    Energy Technology Data Exchange (ETDEWEB)

    Lomperski, S. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439-4840 (United States)], E-mail: lomperski@anl.gov; Farmer, M.T. [Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439-4840 (United States)], E-mail: farmer@anl.gov

    2009-11-15

    Corium strength is of interest in the context of a severe reactor accident in which molten core material melts through the reactor vessel and collects on the containment basemat. Some accident management strategies involve pouring water over the melt to solidify it and halt corium/concrete interactions. The effectiveness of this method could be influenced by the strength of the corium crust at the interface between the melt and coolant. A strong, coherent crust anchored to the containment walls could allow the yet-molten corium to fall away from the crust as it erodes the basemat, thereby thermally decoupling the melt from the coolant and sharply reducing the cooling rate. This paper presents a diverse collection of measurements of the mechanical strength of corium. The data is based on load tests of corium samples in three different contexts: (1) small blocks cut from the debris of the large-scale MACE experiments, (2) 30 cm-diameter, 75 kg ingots produced by SSWICS quench tests, and (3) high temperature crusts loaded during large-scale corium/concrete interaction (CCI) tests. In every case the corium consisted of varying proportions of UO{sub 2}, ZrO{sub 2}, and the constituents of concrete to represent a LWR melt at different stages of a molten core/concrete interaction. The collection of data was used to assess the strength and stability of an anchored, plant-scale crust. The results indicate that such a crust is likely to be too weak to support itself above the melt. It is therefore improbable that an anchored crust configuration could persist and the melt become thermally decoupled from the water layer to restrict cooling and prolong an attack of the reactor cavity concrete.

  15. Socio-economic factors associated with a healthy diet: results from the E3N study.

    Science.gov (United States)

    Affret, Aurélie; Severi, Gianluca; Dow, Courtney; Rey, Grégoire; Delpierre, Cyrille; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Fagherazzi, Guy

    2017-06-01

    To identify individual and contextual socio-economic factors associated with a healthy diet. Dietary data from a large cohort study were used to derive two mutually exclusive dietary patterns through a latent class analysis. Associations between dietary patterns and socio-economic factors were studied with logistic regression. E3N, a French prospective cohort study composed of women recruited from a national health insurance plan covering people working in the national education system. E3N participants (n 73 031) with dietary and socio-economic data available. The 'Healthy' pattern was characterized by a large consumption of fruits and vegetables and the 'Less Healthy' pattern by a large consumption of pizza and processed meat. When all socio-economic factors were analysed together, all of the individual factors considered were associated with a healthy diet (e.g. women with three or more children were less likely to follow a healthy diet v. women with no children, OR (95 % CI): 0·70 (0·66, 0·75)) while the contextual factors associated with a healthy diet included the size of the agglomeration of residence and the area of birth and residence (e.g. women living in the West of France were less likely to follow a healthy diet v. those living in the South of France: 0·78 (0·72, 0·83)). We demonstrated that individual and contextual factors are both associated with diet. Rather than focusing only on individual factors, we recommend future studies or public health and nutritional strategies on diet to consider both types of factors.

  16. Chang'e 3 and Jade Rabbit's: observations and the landing zone

    Science.gov (United States)

    Ping, Jinsong

    Chang’E-3 was launched and landed on the near side of the Moon in December 2013. It is realizing the 2nd phase of Chinese lunar scientific exploration projects. Together with the various in-situ optical observations around the landing sites, the mission carried 4 kinds of radio science experiments, cover the various lunar scientific disciplines as well as lunar surface radio astronomy studies. The key payloads onboard the lander and rover include the near ultraviolet telescope, extreme ultraviolet cameras, ground penetrating radar, very low frequency radio spectrum analyzer, which have not been used in earlier lunar landing missions. Optical spectrometer, Alpha Paticle X-ray spectrometer and Gama Ray spectrometer is also used. The mission is using extreme ultraviolet camera to observe the sun activity and geomagnetic disturbances on geo-space plasma layer of extreme ultraviolet radiation, studying space weather in the plasma layer role in the process; the mission also carries the first time lunar base optical astronomical observations. Most importantly, the topography, landforms and geological structure has been explored in detail. Additionally, the very precise Earth-Moon radio phase ranging technique was firstly tested and realized in this mission. It may increase the study of lunar dyanmics together with LLR technique. Similar to Luna-Glob landers, together with the VLBI radio beacons, the radio transponders are also set on the Chang’E-3. Transponder will receive the uplink X band radio wave transmitted from the two newly constructed Chinese deep space stations, where the high quality hydrogen maser atomic clocks have been used as local time and frequency standard. Radio science receivers have been developed by updating the multi-channel open loop Doppler receiver developed for VLBI and Doppler tracking in Yinghuo-1 and Phobos-Glob Martian missions. This experiment will improve the study of lunar dynamics, by means of measuring the lunar physical liberations

  17. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.

    Science.gov (United States)

    Wan, Lixin; Chen, Ming; Cao, Juxiang; Dai, Xiangpeng; Yin, Qing; Zhang, Jinfang; Song, Su-Jung; Lu, Ying; Liu, Jing; Inuzuka, Hiroyuki; Katon, Jesse M; Berry, Kelsey; Fung, Jacqueline; Ng, Christopher; Liu, Pengda; Song, Min Sup; Xue, Lian; Bronson, Roderick T; Kirschner, Marc W; Cui, Rutao; Pandolfi, Pier Paolo; Wei, Wenyi

    2017-04-01

    BRAF drives tumorigenesis by coordinating the activation of the RAS/RAF/MEK/ERK oncogenic signaling cascade. However, upstream pathways governing BRAF kinase activity and protein stability remain undefined. Here, we report that in primary cells with active APC FZR1 , APC FZR1 earmarks BRAF for ubiquitination-mediated proteolysis, whereas in cancer cells with APC-free FZR1, FZR1 suppresses BRAF through disrupting BRAF dimerization. Moreover, we identified FZR1 as a direct target of ERK and CYCLIN D1/CDK4 kinases. Phosphorylation of FZR1 inhibits APC FZR1 , leading to elevation of a cohort of oncogenic APC FZR1 substrates to facilitate melanomagenesis. Importantly, CDK4 and/or BRAF/MEK inhibitors restore APC FZR1 E3 ligase activity, which might be critical for their clinical effects. Furthermore, FZR1 depletion cooperates with AKT hyperactivation to transform primary melanocytes, whereas genetic ablation of Fzr1 synergizes with Pten loss, leading to aberrant coactivation of BRAF/ERK and AKT signaling in mice. Our findings therefore reveal a reciprocal suppression mechanism between FZR1 and BRAF in controlling tumorigenesis. Significance: FZR1 inhibits BRAF oncogenic functions via both APC-dependent proteolysis and APC-independent disruption of BRAF dimers, whereas hyperactivated ERK and CDK4 reciprocally suppress APC FZR1 E3 ligase activity. Aberrancies in this newly defined signaling network might account for BRAF hyperactivation in human cancers, suggesting that targeting CYCLIN D1/CDK4, alone or in combination with BRAF/MEK inhibition, can be an effective anti-melanoma therapy. Cancer Discov; 7(4); 424-41. ©2017 AACR. See related commentary by Zhang and Bollag, p. 356 This article is highlighted in the In This Issue feature, p. 339 . ©2017 American Association for Cancer Research.

  18. E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue.

    Science.gov (United States)

    Lim, Jung Hwa; Shin, Hee Won; Chung, Kyung-Sook; Kim, Nam-Soon; Kim, Ju Hee; Jung, Hong-Ryul; Im, Dong-Soo; Jung, Cho-Rok

    Here, we show that E2-EPF ubiquitin carrier protein (UCP) elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL) and its own lysine residues both in vitro and in vivo. The initiation of the ubiquitin reaction depended on not only Lys11 linkage but also the Lys6, Lys48 and Lys63 residues of ubiquitin, which were involved in polyubiquitin chain formation on UCP itself. UCP self-association occurred through the UBC domain, which also contributed to the interaction with pVHL. The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination. The Lys76 residue of UCP was the most critical site for auto-ubiquitination, whereas the polyubiquitin chain formation on pVHL occurred on all three of its lysines (Lys159, Lys171 and Lys196). A UCP mutant in which Cys118 was changed to alanine (UCPC118A) did not form a polyubiquitin chain but did strongly accumulate mono- and di-ubiquitin via auto-ubiquitination. Polyubiquitin chain formation required the coordination of Cys95 and Cys118 between two interacting molecules. The mechanism of the polyubiquitin chain reaction of UCP may involve the transfer of ubiquitin from Cys95 to Cys118 by trans-thiolation, with polyubiquitin chains forming at Cys118 by reversible thioester bonding. The polyubiquitin chains are then moved to the lysine residues of the substrate by irreversible isopeptide bonding. During the elongation of the ubiquitin chain, an active Cys118 residue is required in both parts of UCP, namely, the catalytic enzyme and the substrate. In conclusion, UCP possesses not only E2 ubiquitin conjugating enzyme activity but also E3 ubiquitin ligase activity, and Cys118 is critical for polyubiquitin chain formation.

  19. E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue.

    Directory of Open Access Journals (Sweden)

    Jung Hwa Lim

    Full Text Available Here, we show that E2-EPF ubiquitin carrier protein (UCP elongated E3-independent polyubiquitin chains on the lysine residues of von Hippel-Lindau protein (pVHL and its own lysine residues both in vitro and in vivo. The initiation of the ubiquitin reaction depended on not only Lys11 linkage but also the Lys6, Lys48 and Lys63 residues of ubiquitin, which were involved in polyubiquitin chain formation on UCP itself. UCP self-association occurred through the UBC domain, which also contributed to the interaction with pVHL. The polyubiquitin chains appeared on the N-terminus of UCP in vivo, which indicated that the N-terminus of UCP contains target lysines for polyubiquitination. The Lys76 residue of UCP was the most critical site for auto-ubiquitination, whereas the polyubiquitin chain formation on pVHL occurred on all three of its lysines (Lys159, Lys171 and Lys196. A UCP mutant in which Cys118 was changed to alanine (UCPC118A did not form a polyubiquitin chain but did strongly accumulate mono- and di-ubiquitin via auto-ubiquitination. Polyubiquitin chain formation required the coordination of Cys95 and Cys118 between two interacting molecules. The mechanism of the polyubiquitin chain reaction of UCP may involve the transfer of ubiquitin from Cys95 to Cys118 by trans-thiolation, with polyubiquitin chains forming at Cys118 by reversible thioester bonding. The polyubiquitin chains are then moved to the lysine residues of the substrate by irreversible isopeptide bonding. During the elongation of the ubiquitin chain, an active Cys118 residue is required in both parts of UCP, namely, the catalytic enzyme and the substrate. In conclusion, UCP possesses not only E2 ubiquitin conjugating enzyme activity but also E3 ubiquitin ligase activity, and Cys118 is critical for polyubiquitin chain formation.

  20. Strength capability while kneeling.

    Science.gov (United States)

    Haslegrave, C M; Tracy, M F; Corlett, E N

    1997-12-01

    Work sometimes has to be carried out kneeling, particularly where jobs are performed in confined spaces as is common for miners, aircraft baggage handlers and maintenance workers. In order to assess the risks in performing forceful tasks under such conditions, data is needed on strength capabilities of kneeling subjects. A study was undertaken to measure isometric strength in single-handed exertions for male subjects and to investigate the effects on this of task layout factors (direction of force exertion, reach distance, height of the workpiece and orientation relative to the subject's sagittal plane). The data has been tabulated to show the degree to which strength may be reduced in different situations and analysis of the task factors showed their influence to be complex with direction of exertion and reach distance having the greatest effect. The results also suggest that exertions are weaker when subjects are kneeling on two knees than when kneeling on one knee, although this needs to be confirmed by direct experimental comparison.

  1. Gastrointestinal transit and reflux studies

    International Nuclear Information System (INIS)

    Greenspan, R.L.; Kochan, J.

    1988-01-01

    Current imaging modalities such as magnetic resonance imaging and computed tomography provide anatomic resolution far beyond that achievable with the current methods of scintigraphic imaging. Consequently, the strength of nuclear medicine has shifted and now lies in its ability to provide physiologic data noninvasively and simply. This ability is well illustrated by the scintigraphic techniques developed for evaluation of the alimentary tract. Studies of esophageal transit, gastroesophageal reflux, and gastric emptying are now widely available. Evaluation of small and large intestinal transit have also been investigated. These techniques are discussed in the present chapter

  2. Overexpression of herbaceous peony miR156e-3p improves anthocyanin accumulation in transgenic Arabidopsis thaliana lateral branches.

    Science.gov (United States)

    Zhao, Daqiu; Xia, Xing; Wei, Mengran; Sun, Jing; Meng, Jiasong; Tao, Jun

    2017-12-01

    microRNAs (miRNAs) play critical regulatory roles in plant growth and development. In the present study, the function of herbaceous peony ( Paeonia lactiflora Pall.) miR156e-3p in the regulation of color formation has been investigated. Firstly, P. lactiflora miR156e-3p precursor sequence (pre-miR156e-3p) was isolated. Subsequently, the overexpression vector of pre-miR156e-3p was constructed and transformed into Arabidopsis thaliana . Moreover, the medium screening, GUS staining, polymerase chain reaction (PCR) of the GUS region and real-time quantitative PCR (qRT-PCR) of miR156e-3p all confirmed that the purpose gene had been successfully transferred into Arabidopsis plants and expressed, which resulted in apparent purple lateral branches. And this change in color was caused by the improved anthocyanin accumulation. In addition, expression analysis had shown that the level of miR156e-3p transcript was increased, while transcription level of target gene squamosa promoter binding protein-like gene ( SPL1 ), encoding SPL transcription factor that negatively regulated anthocyanin accumulation, was repressed in miR156e-3p-overexpressing transgenic plants, and its downstream gene dihydroflavonol 4-reductase gene ( DFR ) that was directly involved in anthocyanin biosynthesis was strongly expressed, which resulted in anthocyanin accumulation of Arabidopsis lateral branches. These findings would improve the understanding of miRNAs regulation of color formation in P. lactiflora .

  3. Strengths only or strengths and relative weaknesses? A preliminary study.

    Science.gov (United States)

    Rust, Teri; Diessner, Rhett; Reade, Lindsay

    2009-10-01

    Does working on developing character strengths and relative character weaknesses cause lower life satisfaction than working on developing character strengths only? The present study provides a preliminary answer. After 76 college students completed the Values in Action Inventory of Strengths (C. Peterson & M. E. P. Seligman, 2004), the authors randomly assigned them to work on 2 character strengths or on 1 character strength and 1 relative weakness. Combined, these groups showed significant gains on the Satisfaction With Life Scale (E. Diener, R. A. Emmons, R. J. Larsen, & S. Griffin, 1985), compared with a 32-student no-treatment group. However, there was no significant difference in gain scores between the 2-strengths group and the 1-character-strength-and-1-relative-character-weakness group. The authors discuss how focusing on relative character weaknesses (along with strengths) does not diminish-and may assist in increasing-life satisfaction.

  4. Transitions in the cadmium sequence

    International Nuclear Information System (INIS)

    Hibbert, A.

    1982-01-01

    We present calculations of oscillator strengths of the 5s 2 1 S 0 -5s5p sup(1,3)P 1 transitions for Cd I, In II, I VI and Xe VII, using configuration interaction wave functions which take into account valence shell correlation only. It is found that for the intercombination line there is reasonable agreement between theory and experiment, but for the allowed transitions, in I VI and Xe VII, the theoretical and experimental oscillator strengths differ by about a factor of 2. A major part of this disagreement is removed when correction factors, representing the use of experimental energy splittings and the effect of the core, are applied to the ab initio results. (orig.)

  5. Strength Training: For Overall Fitness

    Science.gov (United States)

    Healthy Lifestyle Fitness Strength training is an important part of an overall fitness program. Here's what strength training can do for ... is a key component of overall health and fitness for everyone. Lean muscle mass naturally diminishes with ...

  6. Fine-structure energy levels, oscillator strengths and lifetimes

    Indian Academy of Sciences (India)

    We have done relativistic calculations for the evaluation of energy levels, oscillator strengths, transition probabilities and lifetimes for Cr VIII ion. Use has been made of configuration interaction technique by including Briet–Pauli approximation. The energies of various levels from the ground state to excited levels of 3s3p6, ...

  7. Sustainable energy development in Austria until 2020: Insights from applying the integrated model 'e3.at'

    International Nuclear Information System (INIS)

    Stocker, Andrea; Grossmann, Anett; Madlener, Reinhard; Wolter, Marc Ingo

    2011-01-01

    This paper reports on the Austrian research project 'Renewable energy in Austria: Modeling possible development trends until 2020'. The project investigated possible economic and ecological effects of a substantially increased use of renewable energy sources in Austria. Together with stakeholders and experts, three different scenarios were defined, specifying possible development trends for renewable energy in Austria. The scenarios were simulated for the period 2006-2020, using the integrated environment-energy-economy model 'e3.at'. The modeling results indicate that increasing the share of renewable energy sources in total energy use is an important but insufficient step towards achieving a sustainable energy system in Austria. A substantial increase in energy efficiency and a reduction of residential energy consumption also form important cornerstones of a sustainable energy policy. - Highlights: → Together with stakeholders three renewable energy scenarios for Austria were defined. → The scenarios were simulated using an integrated environment-energy-economy model. → Increasing the share of renewables in total energy use is important but insufficient. → Efficiency and a cut of energy use are also essential for a sustainable energy system.

  8. Correlated compositional and mineralogical investigations at the Chang′e-3 landing site

    Science.gov (United States)

    Ling, Zongcheng; Jolliff, Bradley L.; Wang, Alian; Li, Chunlai; Liu, Jianzhong; Zhang, Jiang; Li, Bo; Sun, Lingzhi; Chen, Jian; Xiao, Long; Liu, Jianjun; Ren, Xin; Peng, Wenxi; Wang, Huanyu; Cui, Xingzhu; He, Zhiping; Wang, Jianyu

    2015-01-01

    The chemical compositions of relatively young mare lava flows have implications for the late volcanism on the Moon. Here we report the composition of soil along the rim of a 450-m diameter fresh crater at the Chang′e-3 (CE-3) landing site, investigated by the Yutu rover with in situ APXS (Active Particle-induced X-ray Spectrometer) and VNIS (Visible and Near-infrared Imaging Spectrometer) measurements. Results indicate that this region's composition differs from other mare sample-return sites and is a new type of mare basalt not previously sampled, but consistent with remote sensing. The CE-3 regolith derived from olivine-normative basaltic rocks with high FeO/(FeO+MgO). Deconvolution of the VNIS data indicates abundant high-Ca ferropyroxene (augite and pigeonite) plus Fe-rich olivine. We infer from the regolith composition that the basaltic source rocks formed during late-stage magma-ocean differentiation when dense ferropyroxene-ilmenite cumulates sank and mixed with deeper, relatively ferroan olivine and orthopyroxene in a hybridized mantle source. PMID:26694712

  9. Preface: The Chang'e-3 lander and rover mission to the Moon

    International Nuclear Information System (INIS)

    Ip Wing-Huen; Yan Jun; Li Chun-Lai; Ouyang Zi-Yuan

    2014-01-01

    The Chang'e-3 (CE-3) lander and rover mission to the Moon was an intermediate step in China's lunar exploration program, which will be followed by a sample return mission. The lander was equipped with a number of remote-sensing instruments including a pair of cameras (Landing Camera and Terrain Camera) for recording the landing process and surveying terrain, an extreme ultraviolet camera for monitoring activities in the Earth's plasmasphere, and a first-ever Moon-based ultraviolet telescope for astronomical observations. The Yutu rover successfully carried out close-up observations with the Panoramic Camera, mineralogical investigations with the VIS-NIR Imaging Spectrometer, study of elemental abundances with the Active Particle-induced X-ray Spectrometer, and pioneering measurements of the lunar subsurface with Lunar Penetrating Radar. This special issue provides a collection of key information on the instrumental designs, calibration methods and data processing procedures used by these experiments with a perspective of facilitating further analyses of scientific data from CE-3 in preparation for future missions

  10. Correlated compositional and mineralogical investigations at the Chang'e-3 landing site.

    Science.gov (United States)

    Ling, Zongcheng; Jolliff, Bradley L; Wang, Alian; Li, Chunlai; Liu, Jianzhong; Zhang, Jiang; Li, Bo; Sun, Lingzhi; Chen, Jian; Xiao, Long; Liu, Jianjun; Ren, Xin; Peng, Wenxi; Wang, Huanyu; Cui, Xingzhu; He, Zhiping; Wang, Jianyu

    2015-12-22

    The chemical compositions of relatively young mare lava flows have implications for the late volcanism on the Moon. Here we report the composition of soil along the rim of a 450-m diameter fresh crater at the Chang'e-3 (CE-3) landing site, investigated by the Yutu rover with in situ APXS (Active Particle-induced X-ray Spectrometer) and VNIS (Visible and Near-infrared Imaging Spectrometer) measurements. Results indicate that this region's composition differs from other mare sample-return sites and is a new type of mare basalt not previously sampled, but consistent with remote sensing. The CE-3 regolith derived from olivine-normative basaltic rocks with high FeO/(FeO+MgO). Deconvolution of the VNIS data indicates abundant high-Ca ferropyroxene (augite and pigeonite) plus Fe-rich olivine. We infer from the regolith composition that the basaltic source rocks formed during late-stage magma-ocean differentiation when dense ferropyroxene-ilmenite cumulates sank and mixed with deeper, relatively ferroan olivine and orthopyroxene in a hybridized mantle source.

  11. SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements.

    Directory of Open Access Journals (Sweden)

    Jason Liang

    2018-03-01

    Full Text Available Mms21, a subunit of the Smc5/6 complex, possesses an E3 ligase activity for the Small Ubiquitin-like MOdifier (SUMO. Here we show that the mms21-CH mutation, which inactivates Mms21 ligase activity, causes increased accumulation of gross chromosomal rearrangements (GCRs selected in the dGCR assay. These dGCRs are formed by non-allelic homologous recombination between divergent DNA sequences mediated by Rad52-, Rrm3- and Pol32-dependent break-induced replication. Combining mms21-CH with sgs1Δ caused a synergistic increase in GCRs rates, indicating the distinct roles of Mms21 and Sgs1 in suppressing GCRs. The mms21-CH mutation also caused increased rates of accumulating uGCRs mediated by breakpoints in unique sequences as revealed by whole genome sequencing. Consistent with the accumulation of endogenous DNA lesions, mms21-CH mutants accumulate increased levels of spontaneous Rad52 and Ddc2 foci and had a hyper-activated DNA damage checkpoint. Together, these findings support that Mms21 prevents the accumulation of spontaneous DNA lesions that cause diverse GCRs.

  12. Preface: The Chang'e-3 lander and rover mission to the Moon

    Science.gov (United States)

    Ip, Wing-Huen; Yan, Jun; Li, Chun-Lai; Ouyang, Zi-Yuan

    2014-12-01

    The Chang'e-3 (CE-3) lander and rover mission to the Moon was an intermediate step in China's lunar exploration program, which will be followed by a sample return mission. The lander was equipped with a number of remote-sensing instruments including a pair of cameras (Landing Camera and Terrain Camera) for recording the landing process and surveying terrain, an extreme ultraviolet camera for monitoring activities in the Earth's plasmasphere, and a first-ever Moon-based ultraviolet telescope for astronomical observations. The Yutu rover successfully carried out close-up observations with the Panoramic Camera, mineralogical investigations with the VIS-NIR Imaging Spectrometer, study of elemental abundances with the Active Particle-induced X-ray Spectrometer, and pioneering measurements of the lunar subsurface with Lunar Penetrating Radar. This special issue provides a collection of key information on the instrumental designs, calibration methods and data processing procedures used by these experiments with a perspective of facilitating further analyses of scientific data from CE-3 in preparation for future missions.

  13. The Processing of Lunar Penetrating Radar Channel-2B Data from Chang'E-3

    Science.gov (United States)

    Zhu, P.; Zhao, N.; Yang, K.; Yuan, Y.; Guo, S.

    2014-12-01

    The Lunar Penetrating Radar (LPR) carried by Chang'E-3 has imaged the shallow subsurface of the landing site at the northern Mare Imbrium. The antenna B of the Channel-2 onboard the LPR (LPR Channel-2B) has collected more than 20000 traces of raw data. The raw LPR data could not be directly used for geological interpretation because of the operation mode of the LPR, noise and fast attenuation of radar wave. This study focuses data preprocessing and processing methods to obtain higher quality data. A section of usable LPR data of over 2000 traces is gained after the preprocessing of selecting, splicing, removing delay time and fine-correcting to raw data, but only a few shallow geological structures are visible. To further improve the resolution and the signal-to-noise ratio of the LPR data, we have processed the LPR data including amplitude compensation, filtering, and deconvolution processes based on electromagnetic wave theory. The processing results reveal that (1) the spherical spreading compensation and auto gain control enhance the amplitude of reflection echoes from deeper strata and make the geological structures more obvious, (2) the spiking deconvolution applied to narrow reflection events down makes it possible to identify thin layers with 30% improved resolution, and (3) the band-pass filtering removes the multiple reflections and, consequently, improves the signal-to-noise ratio of LPR data. The processing results will lay the foundation for the subsequent geological interpretation and physical property inversion of lunar materials.

  14. Deviations between experimental and theoretical results in Ar (e, 3e) double ionization

    International Nuclear Information System (INIS)

    Jia, C C; Lahmam-Bennani, A; Cappello, C Dal; Duguet, A; Avaldi, L

    2003-01-01

    The coplanar (e, 3e) relative cross sections for double ionization of argon have been measured at an electron impact energy of E 0 = 561.4 eV and under equal energy sharing among the two 'ejected' electrons, E b = E c = 9 eV. The scattering angle is fixed to θ a = 1.5 degrees, corresponding to a momentum transfer K=0.4 au to the target. The experimental results have been compared with calculations in the first Born approximation, which include only first-order processes in the target-projectile interaction. The comparison shows severe deviations between the experimental and theoretical results. These deviations are much larger than the ones previously observed in helium under comparable kinematics. To fill this gap between theory and experiment, a decisive improvement in the theory is needed. This can be achieved by improving the first-order calculations and by including higher-order processes such as the two-step mechanism, or even new mechanisms, for instance the simultaneous ejection of the pair of target electrons. (letter to the editor)

  15. The Impact of Parametric Uncertainties on Biogeochemistry in the E3SM Land Model

    Science.gov (United States)

    Ricciuto, Daniel; Sargsyan, Khachik; Thornton, Peter

    2018-02-01

    We conduct a global sensitivity analysis (GSA) of the Energy Exascale Earth System Model (E3SM), land model (ELM) to calculate the sensitivity of five key carbon cycle outputs to 68 model parameters. This GSA is conducted by first constructing a Polynomial Chaos (PC) surrogate via new Weighted Iterative Bayesian Compressive Sensing (WIBCS) algorithm for adaptive basis growth leading to a sparse, high-dimensional PC surrogate with 3,000 model evaluations. The PC surrogate allows efficient extraction of GSA information leading to further dimensionality reduction. The GSA is performed at 96 FLUXNET sites covering multiple plant functional types (PFTs) and climate conditions. About 20 of the model parameters are identified as sensitive with the rest being relatively insensitive across all outputs and PFTs. These sensitivities are dependent on PFT, and are relatively consistent among sites within the same PFT. The five model outputs have a majority of their highly sensitive parameters in common. A common subset of sensitive parameters is also shared among PFTs, but some parameters are specific to certain types (e.g., deciduous phenology). The relative importance of these parameters shifts significantly among PFTs and with climatic variables such as mean annual temperature.

  16. An assessment of Japanese carbon tax reform using the E3MG econometric model.

    Science.gov (United States)

    Lee, Soocheol; Pollitt, Hector; Ueta, Kazuhiro

    2012-01-01

    This paper analyses the potential economic and environmental effects of carbon taxation in Japan using the E3MG model, a global macroeconometric model constructed by the University of Cambridge and Cambridge Econometrics. The paper approaches the issues by considering first the impacts of the carbon tax in Japan introduced in 2012 and then the measures necessary to reduce Japan's emissions in line with its Copenhagen pledge of -25% compared to 1990 levels. The results from the model suggest that FY2012 Tax Reform has only a small impact on emission levels and no significant impact on GDP and employment. The potential costs of reducing emissions to meet the 25% reduction target for 2020 are quite modest, but noticeable. GDP falls by around 1.2% compared to the baseline and employment by 0.4% compared to the baseline. But this could be offset, with some potential economic benefits, if revenues are recycled efficiently. This paper considers two revenue recycling scenarios. The most positive outcome is if revenues are used both to reduce income tax rates and to increase investment in energy efficiency. This paper shows there could be double dividend effects, if Carbon Tax Reform is properly designed.

  17. An Assessment of Japanese Carbon Tax Reform Using the E3MG Econometric Model

    Directory of Open Access Journals (Sweden)

    Soocheol Lee

    2012-01-01

    Full Text Available This paper analyses the potential economic and environmental effects of carbon taxation in Japan using the E3MG model, a global macroeconometric model constructed by the University of Cambridge and Cambridge Econometrics. The paper approaches the issues by considering first the impacts of the carbon tax in Japan introduced in 2012 and then the measures necessary to reduce Japan’s emissions in line with its Copenhagen pledge of −25% compared to 1990 levels. The results from the model suggest that FY2012 Tax Reform has only a small impact on emission levels and no significant impact on GDP and employment. The potential costs of reducing emissions to meet the 25% reduction target for 2020 are quite modest, but noticeable. GDP falls by around 1.2% compared to the baseline and employment by 0.4% compared to the baseline. But this could be offset, with some potential economic benefits, if revenues are recycled efficiently. This paper considers two revenue recycling scenarios. The most positive outcome is if revenues are used both to reduce income tax rates and to increase investment in energy efficiency. This paper shows there could be double dividend effects, if Carbon Tax Reform is properly designed.

  18. An Assessment of Japanese Carbon Tax Reform Using the E3MG Econometric Model

    Science.gov (United States)

    Lee, Soocheol; Pollitt, Hector; Ueta, Kazuhiro

    2012-01-01

    This paper analyses the potential economic and environmental effects of carbon taxation in Japan using the E3MG model, a global macroeconometric model constructed by the University of Cambridge and Cambridge Econometrics. The paper approaches the issues by considering first the impacts of the carbon tax in Japan introduced in 2012 and then the measures necessary to reduce Japan's emissions in line with its Copenhagen pledge of −25% compared to 1990 levels. The results from the model suggest that FY2012 Tax Reform has only a small impact on emission levels and no significant impact on GDP and employment. The potential costs of reducing emissions to meet the 25% reduction target for 2020 are quite modest, but noticeable. GDP falls by around 1.2% compared to the baseline and employment by 0.4% compared to the baseline. But this could be offset, with some potential economic benefits, if revenues are recycled efficiently. This paper considers two revenue recycling scenarios. The most positive outcome is if revenues are used both to reduce income tax rates and to increase investment in energy efficiency. This paper shows there could be double dividend effects, if Carbon Tax Reform is properly designed. PMID:23365531

  19. Reaction (γ,2e) and (e,3e) as probe of electron correlation in atoms

    International Nuclear Information System (INIS)

    Amusia, M.Y.

    1995-01-01

    Cross sections of the (γ,2e) and (e,3e) reactions contain information about the two vacancy-energy spectrum and electron-pair correlations in initial and final states of the target atom. Physical pictures of these processes are presented for two- and many-electron atoms. The simplest mechanisms are discussed, demonstrating some features which await experimental confirmation. Attention is given to high photon energy and the relativistic energy region of these reactions. The energy distribution of outgoing relativistic electrons is qualitatively different from the nonrelativistic case. The origin and types of corrections to the simplest mechanisms, and possible means of their detection, are discussed. In addition, the role of different resonances: shape, giant, autoionizational, and Feshbach-type are considered. Results of calculations are compared with experimental data, mainly on double photoionization cross sections. Different possible objects as targets for the reactions are considered, including negative ions, excited atoms, molecules, and clusters. The modification of these reactions due to photon emission is discussed. The future of the domain is outlined

  20. Reactions (γ,2e) and (e,3e) as probes of electronic correlations in atoms

    International Nuclear Information System (INIS)

    Amusia, M.Ya.

    1993-01-01

    Cross sections of the (γ,2e) and (e,3e) reactions carry information on two vacancy energy spectrum and on electron pair correlations in initial and final states of the target atom. Physical pictures of these processes are presented for two- and many-electron atoms. Simplest mechanisms of them are discussed, demonstrating some features which are waiting for experimental confirmation. Attention is given to high photon energy and even to relativistic energy region of these reactions. The energy distribution of outgoing relativistic electrons is qualitatively different from what it is for the nonrelativistic case. Origin and types of corrections to the simplest mechanisms and possible means of their detection are discussed. Role of different resonances: shape, giant, autoionizational, and Feschbach-type are considered. Results of calculations are compared with experimental data, mainly on double photoionization cross sections. Different possible objects as targets for the reactions are mentioned, including negative ions, excited atoms, molecules and clusters. Modification of the type of these reactions due to rather probable emission of the photon is discussed. Future of the domain is outlined. (orig.)

  1. Mutation in SUMO E3 ligase, SIZ1, disrupts the mature female gametophyte in Arabidopsis

    KAUST Repository

    Ling, Yu

    2012-01-09

    Female gametophyte is the multicellular haploid structure that can produce embryo and endosperm after fertilization, which has become an attractive model system for investigating molecular mechanisms in nuclei migration, cell specification, cell-to-cell communication and many other processes. Previous reports found that the small ubiquitin-like modifier (SUMO) E3 ligase, SIZ1, participated in many processes depending on particular target substrates and suppression of salicylic acid (SA) accumulation. Here, we report that SIZ1 mediates the reproductive process. SIZ1 showed enhanced expression in female organs, but was not detected in the anther or pollen. A defect in the siz1-2 maternal source resulted in reduced seed-set regardless of high SA concentration within the plant. Moreover, aniline blue staining and scanning electron microscopy revealed that funicular and micropylar pollen tube guidance was arrested in siz1-2 plants. Some of the embryo sacs of ovules in siz1-2 were also disrupted quickly after stage FG7. There was no significant affects of the siz1-2 mutation on expression of genes involved in female gametophyte development- or pollen tube guidance in ovaries. Together, our results suggest that SIZ1 sustains the stability and normal function of the mature female gametophyte which is necessary for pollen tube guidance. © 2012 Ling et al.

  2. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity

    KAUST Repository

    Lin, Xiao-Li

    2016-04-29

    COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype. SIZ1 physically interacts with COP1 and mediates the sumoylation of COP1. A K193R substitution in COP1 blocks its SUMO modification and reduces COP1 activity in vitro and in planta. Consistently, COP1 activity is reduced in siz1 and the level of HY5, a COP1 target protein, is increased in siz1. Sumoylated COP1 may exhibits higher transubiquitination activity than does non-sumoylated COP1, but SIZ1-mediated SUMO modification does not affect COP1 dimerization, COP1-HY5 interaction, and nuclear accumulation of COP1. Interestingly, prolonged light exposure reduces the sumoylation level of COP1, and COP1 mediates the ubiquitination and degradation of SIZ1. These regulatory mechanisms may maintain the homeostasis of COP1 activity, ensuing proper photomorphogenic development in changing light environment. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.

  3. An Arabidopsis SUMO E3 Ligase, SIZ1, Negatively Regulates Photomorphogenesis by Promoting COP1 Activity

    KAUST Repository

    Lin, Xiao-Li; Niu, De; Hu, Zi-Liang; Kim, Dae Heon; Jin, Yin Hua; Cai, Bin; Liu, Peng; Miura, Kenji; Yun, Dae-Jin; Kim, Woe-Yeon; Lin, Rongcheng; Jin, Jing Bo

    2016-01-01

    COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function siz1 mutant seedlings exhibit a weak constitutive photomorphogenic phenotype. SIZ1 physically interacts with COP1 and mediates the sumoylation of COP1. A K193R substitution in COP1 blocks its SUMO modification and reduces COP1 activity in vitro and in planta. Consistently, COP1 activity is reduced in siz1 and the level of HY5, a COP1 target protein, is increased in siz1. Sumoylated COP1 may exhibits higher transubiquitination activity than does non-sumoylated COP1, but SIZ1-mediated SUMO modification does not affect COP1 dimerization, COP1-HY5 interaction, and nuclear accumulation of COP1. Interestingly, prolonged light exposure reduces the sumoylation level of COP1, and COP1 mediates the ubiquitination and degradation of SIZ1. These regulatory mechanisms may maintain the homeostasis of COP1 activity, ensuing proper photomorphogenic development in changing light environment. Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.

  4. Modulation of immune cell functions by the E3 ligase CBL-b

    Directory of Open Access Journals (Sweden)

    Christina eLutz-Nicoladoni

    2015-03-01

    Full Text Available Maintenance of immunological tolerance is a critical hallmark of the immune system. Several signaling checkpoints necessary to balance activating and inhibitory input to immune cells have been described so far, among which the E3 ligase Cbl-b appears to be a central player. Cbl-b is expressed in all leukocyte subsets and regulates several signaling pathways in T cells, NK cells, B cells and different types of myeloid cells. In most cases Cbl-b negatively regulates activation signals through antigen or pattern recognition receptors and co-stimulatory molecules. In line with this function, cblb-deficient immune cells display lower activation thresholds and cblb knockout mice spontaneously develop autoimmunity and are highly susceptible to experimental autoimmunity. Interestingly, genetic association studies link cblb-polymorphisms with autoimmunity also in humans. Vice versa, the increased activation potential of cblb-deficient cells renders them more potent to fight against malignancies or infections. Accordingly, several reports have shown that cblb knockout mice reject tumors, which mainly depends on cytotoxic T and NK cells. Thus targeting Cbl-b may be an interesting strategy to enhance anti-cancer immunity. In this review we summarize the findings on the molecular function of Cbl-b in different cell types and illustrate the potential of Cbl-b as target for immunomodulatory therapies.

  5. The evolutionarily conserved E3 ubiquitin ligase AtCHIP contributes to plant immunity

    Directory of Open Access Journals (Sweden)

    Xin eLi

    2016-03-01

    Full Text Available Plants possess a sophisticated immune system to recognize and respond to microbial threats in their environment. The level of immune signaling must be tightly regulated so that immune responses can be quickly activated in the presence of pathogens, while avoiding autoimmunity. HSP90s, along with their diverse array of co-chaperones, forms chaperone complexes that have been shown to play both positive and negative roles in regulating the accumulation of immune receptors and regulators. In this study, we examined the role of AtCHIP, an evolutionarily conserved E3 ligase that was known to interact with chaperones including HSP90s in multicellular organisms including fruit fly, C. elegans, plants and human. Atchip knockout mutants display enhanced disease susceptibility to a virulent oomycete pathogen, and overexpression of AtCHIP causes enhanced disease resistance at low temperature. Although CHIP was reported to target HSP90 for ubiquitination and degradation, accumulation of HSP90.3 was not affected in Atchip plants. In addition, protein accumulation of nucleotide-binding, leucine-rich repeat domain immune receptor (NLR SNC1 is not altered in Atchip mutant. Thus, while AtCHIP plays a role in immunity, it does not seem to regulate the turnover of HSP90 or SNC1. Further investigation is needed in order to determine the exact mechanism behind AtCHIP’s role in regulating plant immune responses.

  6. Test Hardware Design for Flightlike Operation of Advanced Stirling Convertors (ASC-E3)

    Science.gov (United States)

    Oriti, Salvatore M.

    2012-01-01

    NASA Glenn Research Center (GRC) has been supporting development of the Advanced Stirling Radioisotope Generator (ASRG) since 2006. A key element of the ASRG project is providing life, reliability, and performance testing of the Advanced Stirling Convertor (ASC). For this purpose, the Thermal Energy Conversion branch at GRC has been conducting extended operation of a multitude of free-piston Stirling convertors. The goal of this effort is to generate long-term performance data (tens of thousands of hours) simultaneously on multiple units to build a life and reliability database. The test hardware for operation of these convertors was designed to permit in-air investigative testing, such as performance mapping over a range of environmental conditions. With this, there was no requirement to accurately emulate the flight hardware. For the upcoming ASC-E3 units, the decision has been made to assemble the convertors into a flight-like configuration. This means the convertors will be arranged in the dual-opposed configuration in a housing that represents the fit, form, and thermal function of the ASRG. The goal of this effort is to enable system level tests that could not be performed with the traditional test hardware at GRC. This offers the opportunity to perform these system-level tests much earlier in the ASRG flight development, as they would normally not be performed until fabrication of the qualification unit. This paper discusses the requirements, process, and results of this flight-like hardware design activity.

  7. Functional Characterization of the Apple RING E3 Ligase MdMIEL1 in Transgenic Arabidopsis

    Directory of Open Access Journals (Sweden)

    Jianping AN

    2017-03-01

    Full Text Available E3 ubiquitin ligases are involved in various physiological processes, and they play pivotal roles in growth and development. In this study, we identified a previously unknown gene in the apple fruit (Malus × domestica and named it MdMIEL1. The MdMIEL1 gene encoded a protein that contained a zinc-finger domain at its N-terminus and a RING-finger motif at its C-terminus. To investigate MdMIEL1 functions, we generated transgenic Arabidopsis lines expressing the MdMIEL1 gene under the control of the Cauliflower mosaic virus 35S promoter. Interestingly, ectopic expression of MdMIEL1 in Arabidopsis produced multiple phenotypes, including early germination, early flowering and a lateral root number increase relative to wild-type plants. Further analysis indicated that MdMIEL1 regulated lateral root initiation by increasing auxin accumulation in the roots. In a word, these results suggest that, MdMIEL1 as a novel RING-finger ubiquitin ligase influences plant growth and development, and highlight that MdMIEL1 regulates lateral root growth.

  8. TRIM32 ubiquitin E3 ligase, one enzyme for several pathologies: From muscular dystrophy to tumours.

    Science.gov (United States)

    Lazzari, Elisa; Meroni, Germana

    2016-10-01

    TRIM32 is a member of the TRIpartite Motif family characterised by the presence of an N-terminal three-domain-module that includes a RING domain, which confers E3 ubiquitin ligase activity, one or two B-box domains and a Coiled-Coil region that mediates oligomerisation. Several TRIM32 substrates were identified including muscular proteins and proteins involved in cell cycle regulation and cell motility. As ubiquitination is a versatile post-translational modification that can affect target turnover, sub-cellular localisation or activity, it is likely that diverse substrates may be differentially affected by TRIM32-mediated ubiquitination, reflecting its multi-faceted roles in muscle physiology, cancer and immunity. With particular relevance for muscle physiology, mutations in TRIM32 are associated with autosomal recessive Limb-Girdle Muscular Dystrophy 2H, a muscle-wasting disease with variable clinical spectrum ranging from almost asymptomatic to wheelchair-bound patients. In this review, we will focus on the ability of TRIM32 to mark specific substrates for proteasomal degradation discussing how the TRIM32-proteasome axis may (i) be important for muscle homeostasis and for the pathogenesis of muscular dystrophy; and (ii) define either an oncogenic or tumour suppressive role for TRIM32 in the context of different types of cancer. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction Injury.

    Science.gov (United States)

    Xue, Pengfei; Liu, Xiaojuan; Shen, Yiming; Ju, Yuanyuan; Lu, Xiongsong; Zhang, Jinlong; Xu, Guanhua; Sun, Yuyu; Chen, Jiajia; Gu, Haiyan; Cui, Zhiming; Bao, Guofeng

    2018-06-22

    E3 ubiquitin ligase c-Caritas B cell lymphoma (c-cbl) is associated with negative regulation of receptor tyrosine kinases, signal transduction of antigens and cytokine receptors, and immune response. However, the expression and function of c-cbl in the regulation of neuropathic pain after chronic constriction injury (CCI) are unknown. In rat CCI model, c-cbl inhibited the activation of spinal cord microglia and the release of pro-inflammatory factors including tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6), which alleviated mechanical and heat pain through down-regulating extracellular signal-regulated kinase (ERK) pathway. Additionally, exogenous TNF-α inhibited c-cbl protein level vice versa. In the primary microglia transfected with c-cbl siRNA, when treated with TNF-α or TNF-α inhibitor, the corresponding secretion of IL-1β and IL-6 did not change. In summary, CCI down-regulated c-cbl expression and induced the activation of microglia, then activated microglia released inflammatory factors via ERK signaling to cause pain. Our data might supply a novel molecular target for the therapy of CCI-induced neuropathic pain.

  10. Initial clinical evaluation of radiolabeled MX-DTPA humanized BrE-3 antibody in patients with advanced breast cancer.

    Science.gov (United States)

    Kramer, E L; Liebes, L; Wasserheit, C; Noz, M E; Blank, E W; Zabalegui, A; Melamed, J; Furmanski, P; Peterson, J A; Ceriani, R L

    1998-07-01

    To evaluate radiometal-labeled humanized BrE-3 (huBrE-3) monoclonal antibody as a radioimmunolocalization and therapeutic agent in breast cancer patients, tumor localization, pharmacokinetics, radiation dosimetry, and immunogenicity of (111)In-labeled combined 1-p-isothiocyanatobenzyl 3-methyl- and 1-p-isothiocyanatobenzyl 4-methyldiethylenetriamine pentaacetic acid (MX-DTPA) huBrE-3 were studied. Seven women with BrE-3 antigen-positive, metastatic breast carcinoma underwent (111)In huBrE-3 infusion (5 mCi; 50 mg), followed by serial gamma camera imaging and plasma sampling. Region of interest analysis of images was used to make radiation absorbed dose estimates for (111)In huBrE-3. Data were extrapolated to 90Y huBrE-3. Human anti-human antibody (HAHA) response was measured in serum samples obtained up to 3 months after infusion. Patients tolerated infusions well. Seventy-six percent of 105 known sites of disease were identified on planar and single-photon emission computed tomography scans. For six of seven patients, a biexponential model fit the plasma time-activity curve best with an average T1/2alpha=10.6+/-8.5 (SD) h and average T1/2beta=114.2+/-39.2 h. Radiation absorbed dose estimates for (111)In huBrE-3 for whole body averaged 0.53+/-.08 rads/mCi. Dose estimates for 90Y huBrE-3 for marrow averaged 8.4+/-11.9 rads/mCi, and for tumors, 70+/-31.5 rads/mCi. Liver radioactivity uptake averaged 19.7+/-8.8% injected dose at 24 h after infusion, translating into an average radiation absorbed dose 21.1+/-12 rads/90Y mCi administered. Only one of seven patients demonstrated a low level of HAHA response. Although the plasma half-lives are longer and marrow dose higher for radiolabeled huBrE-3 compared with the murine construct, the excellent tumor localization, good tumor dosimetry, and low immunogenicity support the use of 90Y-huBrE-3 antibody for radioimmunotherapy of breast cancer.

  11. Complete replication-competent adenovirus 11p vectors with E1 or E3 insertions show improved heat stability

    Energy Technology Data Exchange (ETDEWEB)

    Mei, Ya-Fang, E-mail: ya-fang.mei@umu.se [Department of Clinical Microbiology and Virology, Umeå University, SE-901 85 Umeå (Sweden); Wu, Haidong, E-mail: haidong.wu@umu.se [Department of Clinical Microbiology and Virology, Umeå University, SE-901 85 Umeå (Sweden); Hultenby, Kjell, E-mail: kjell.hultenby@ki.se [Division of Clinical Research Centre, Department of Laboratory Medicine, Karolinska Institute, SE-14186 Stockholm (Sweden); Silver, Jim, E-mail: jim.silver@umu.se [Department of Clinical Microbiology and Virology, Umeå University, SE-901 85 Umeå (Sweden)

    2016-10-15

    Conventional adenovirus vectors harboring E1 or E3 deletions followed by the insertion of an exogenous gene show considerably reduced virion stability. Here, we report strategies to generate complete replication-competent Ad11p(RCAd11p) vectors that overcome the above disadvantage. A GFP cassette was successfully introduced either upstream of E1A or in the E3A region. The resulting vectors showed high expression levels of the hexon and E1genes and also strongly induced the cytopathic effect in targeted cells. When harboring oversized genomes, the RCAd11pE1 and RCAd11pE3 vectors showed significantly improved heat stability in comparison to Ad11pwt;of the three, RCAd11pE3 was the most tolerant to heat treatment. Electron microscopy showed that RCAd11pE3, RCAd11pE1, Ad11pwt, and Ad11pE1 Delmanifested dominant, moderate, minimum, or no full virus particles after heat treatment at 47 °C for 5 h. Our results demonstrated that both genome size and the insertion site in the viral genome affect virion stability. -- Highlights: •Replicating adenovirus 11p GFP vectors at the E1 or E3 region were generated. •RCAd11pE3 and RCAd11pE1 vectors manifested significantly improved heat stability. •RCAd11pE3 and RCAd11pE1 showed more full viral particles than Ad11pwt after heating. •We demonstrated that both genome size and the insertion site affect virion stability.

  12. Complete replication-competent adenovirus 11p vectors with E1 or E3 insertions show improved heat stability

    International Nuclear Information System (INIS)

    Mei, Ya-Fang; Wu, Haidong; Hultenby, Kjell; Silver, Jim

    2016-01-01

    Conventional adenovirus vectors harboring E1 or E3 deletions followed by the insertion of an exogenous gene show considerably reduced virion stability. Here, we report strategies to generate complete replication-competent Ad11p(RCAd11p) vectors that overcome the above disadvantage. A GFP cassette was successfully introduced either upstream of E1A or in the E3A region. The resulting vectors showed high expression levels of the hexon and E1genes and also strongly induced the cytopathic effect in targeted cells. When harboring oversized genomes, the RCAd11pE1 and RCAd11pE3 vectors showed significantly improved heat stability in comparison to Ad11pwt;of the three, RCAd11pE3 was the most tolerant to heat treatment. Electron microscopy showed that RCAd11pE3, RCAd11pE1, Ad11pwt, and Ad11pE1 Delmanifested dominant, moderate, minimum, or no full virus particles after heat treatment at 47 °C for 5 h. Our results demonstrated that both genome size and the insertion site in the viral genome affect virion stability. -- Highlights: •Replicating adenovirus 11p GFP vectors at the E1 or E3 region were generated. •RCAd11pE3 and RCAd11pE1 vectors manifested significantly improved heat stability. •RCAd11pE3 and RCAd11pE1 showed more full viral particles than Ad11pwt after heating. •We demonstrated that both genome size and the insertion site affect virion stability.

  13. Excitation rates for transitions in Kr XXXII

    Science.gov (United States)

    Aggarwal, K. M.; Keenan, F. P.; Lawson, K. D.

    2009-04-01

    In this paper we report our results for collision strengths and effective collision strengths for transitions among the lowest 125 levels of the 2s22p, 2s2p2, 2p3, 2s23ell, 2s2p3ell, and 2p23ell configurations of Kr XXXII. For our calculations both the FAC and DARC codes have been employed.

  14. Electron scattering studies of selected electric and magnetic dipole and quadrupole transitions in light and heavy nuclei, the new multipole giant resonances and atomic transitions - recent results from the DALINAC

    International Nuclear Information System (INIS)

    Richter, A.

    1977-01-01

    Recent experimental work from the Darmstadt electron linear accelerator (DALINAC) is briefly summarized. Particular emphasis is given to the following topics: high resolution inelastic electron scattering (ΔE approximately 30 keV FWHM) has been used to study the radiative width and magnetization density of the 2 + , T = 1 state at 16.11 MeV in 12 C, E2 strength distribution in 28 Si below an excitation energy of 13 MeV and the isospin forbidden E1 electroexcitation of the 1 - , T = 0 state at 6.95 MeV in 40 Ca. High resolution inelastic electron scattering was also employed to determine certain M1 transitions in 14 N, 28 Si, 39 K, 58 Ni, 90 Zr and 208 Pb and the M2 strength distribution in the two heaviest nuclei. At medium energy resolution (ΔE approximately 200 keV FWHM) spectra at various angles and bombarding energies have been measured from (4-31) MeV for 208 Pb. They are being analyzed in order to determine E0, E1, E2, E3 and M1 giant resonance strength in the continuum. The Z and E dependence and the scaling behaviour of the atomic inner shell ionization cross section at relativistic electron impact is studied on gaseous and solid targets. (orig./BJ) [de

  15. Roles of pinning strength and density in vortex melting

    International Nuclear Information System (INIS)

    Obaidat, I M; Khawaja, U Al; Benkraouda, M

    2008-01-01

    We have investigated the role of pinning strength and density on the equilibrium vortex-lattice to vortex-liquid phase transition under several applied magnetic fields. This study was conducted using a series of molecular dynamic simulations on several samples with different strengths and densities of pinning sites which are arranged in periodic square arrays. We have found a single solid-liquid vortex transition when the vortex filling factor n>1. We have found that, for fixed pinning densities and strengths, the melting temperature, T m , decreases almost linearly with increasing magnetic field. Our results provide direct numerical evidence for the significant role of both the strength and density of pinning centers on the position of the melting line. We have found that the vortex-lattice to vortex-liquid melting line shifts up as the pinning strength or the pinning density was increased. The effect on the melting line was found to be more pronounced at small values of strength and density of pinning sites

  16. Tests of Hadronic Probes of GT Strength

    CERN Multimedia

    2002-01-01

    There are many important problems where one wishes to know the distribution of Gamow-Teller (GT) strength in circumstances where it cannot be measured directly (for example, because of energy-release limitations). Then one must rely on hadronic probes to infer the GT strength. It is therefore essential to test these probes as extensively as possible. The isospin-analog transitions in $^{37}$Ca $\\beta^{+}$ -decay and $^{37}$Cl$(p, n)$ provide an excellent ground for such a test. Recent $^{37}$Cl$ (p, n) $ studies, while qualitatively in agreement with our previous ISOLDE work on $^{37}$Ca $\\beta^{+} $ -decay, show quantitative discrepancies that appear to grow as the excitation energy in the residual nuclei increases. Because of the bulk of the GT strengh appears at these high excitation energies, it is important to extend the $\\beta$-decay data to even higher excitation energies where, because of rapidly diminishing phase-space, strong GT transitions correspond to very weak $\\beta$ -branches. We propose to do...

  17. Strength and lifetime of polymer glasses

    Energy Technology Data Exchange (ETDEWEB)

    Bartenev, G.M.; Kartasov, E.M.

    1981-03-01

    A kinetic equation of the time-dependence of strength (complete isotherm of lifetime) of polymer glasses at stress values ranging from the limiting stress of the occurence of separation breaks to the critical stress is derived. The curvature of lifetime plots occuring at low and high periods of time in the experiments are considered. The ranges of noncritical state, breaks caused by a thermofluctuation mechanism, a transition range and athermal breaks are discerned. The limitations of applicability of the basic empirical equation of the kinetic theory of the time-dependence of strength are explained. Theoretical equations are suggested for calculating various characteristics of the brittle break, as limiting stress and critical stress, relative critical craze length and coefficient of stress concentration at the craze tip with respect to various geometrical configurations of the craze and its position in the sample. With polymethylmethacrylate as an example in the brittle and quasi-brittle state, as characterized by the transition from the rupture of sets of chemical bonds to individual chemical bonds, the thermofluctuation processes of break in polymer glasses are discussed. The application of the thermofluctuation theory of solids to the quasi-brittle fracture is considered. The growth kinetics of crazes and the corresponding equation of lifetime were found to be described by identical (corresponding) analytical expressions by which the changes of the coefficients of stress concentration in the range of microplastic deformation in front of the growing is covered within a wide region of temperature including the brittle temperature.

  18. Gaussian discriminating strength

    Science.gov (United States)

    Rigovacca, L.; Farace, A.; De Pasquale, A.; Giovannetti, V.

    2015-10-01

    We present a quantifier of nonclassical correlations for bipartite, multimode Gaussian states. It is derived from the Discriminating Strength measure, introduced for finite dimensional systems in Farace et al., [New J. Phys. 16, 073010 (2014), 10.1088/1367-2630/16/7/073010]. As the latter the new measure exploits the quantum Chernoff bound to gauge the susceptibility of the composite system with respect to local perturbations induced by unitary gates extracted from a suitable set of allowed transformations (the latter being identified by posing some general requirements). Closed expressions are provided for the case of two-mode Gaussian states obtained by squeezing or by linearly mixing via a beam splitter a factorized two-mode thermal state. For these density matrices, we study how nonclassical correlations are related with the entanglement present in the system and with its total photon number.

  19. M1 and E2 transitions in the ground-state configuration of atomic ...

    Indian Academy of Sciences (India)

    have calculated the forbidden transition (M1 and E2) parameters such as transition energies, log- arithmic weighted ... Keywords. Forbidden transitions; transition energies; logarithmic weighted oscillator strengths; .... optimizing the energy function based on the non-relativistic Hamiltonian of an atom,. HNR = N. ∑ j=1. (12∇ ...

  20. Analysis of the geomorphology surrounding the Chang'e-3 landing site

    International Nuclear Information System (INIS)

    Li Chun-Lai; Mu Ling-Li; Zou Xiao-Duan; Liu Jian-Jun; Ren Xin; Zeng Xing-Guo; Yang Yi-Man; Zhang Zhou-Bin; Liu Yu-Xuan; Zuo Wei; Li Han

    2014-01-01

    Chang'e-3 (CE-3) landed on the Mare Imbrium basin in the east part of Sinus Iridum (19.51°W, 44.12°N), which was China's first soft landing on the Moon and it started collecting data on the lunar surface environment. To better understand the environment of this region, this paper utilizes the available high-resolution topography data, image data and geological data to carry out a detailed analysis and research on the area surrounding the landing site (Sinus Iridum and 45 km×70 km of the landing area) as well as on the topography, landform, geology and lunar dust of the area surrounding the landing site. A general topographic analysis of the surrounding area is based on a digital elevation model and digital elevation model data acquired by Chang'e-2 that have high resolution; the geology analysis is based on lunar geological data published by USGS; the study on topographic factors and distribution of craters and rocks in the surrounding area covering 4 km×4 km or even smaller is based on images from the CE-3 landing camera and images from the topographic camera; an analysis is done of the effect of the CE-3 engine plume on the lunar surface by comparing images before and after the landing using data from the landing camera. A comprehensive analysis of the results shows that the landing site and its surrounding area are identified as typical lunar mare with flat topography. They are suitable for maneuvers by the rover, and are rich in geological phenomena and scientific targets, making it an ideal site for exploration

  1. Life course evolution of body size and breast cancer survival in the E3N cohort.

    Science.gov (United States)

    His, Mathilde; Le Guélennec, Marine; Mesrine, Sylvie; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Dossus, Laure

    2018-04-15

    Although adult obesity has been associated with poor breast cancer survival, data on adiposity at different periods in life and its lifelong evolution are scarce. Our aims were to assess the associations between breast cancer survival and body size during childhood, puberty and early adulthood and body size trajectories from childhood to adulthood. Self-assessed body size at age 8, at puberty, at age 20-25 and at age 35-40 and trajectories of body size of 4,662 breast cancer survivors from the prospective E3N cohort were studied in relation to risk of death from any cause, death from breast cancer and second invasive cancer event using multivariate Cox regression models. Four trajectories of body size were identified (T1 "moderate increase," T2 "stable/low increase," T3 "increase at puberty" and T4 "constantly high"). Compared with stable body size, an increase in body size during adult life was associated with an increased risk of death from any cause (HR T1 vs. T2 = 1.27; 95% CI = 1.01-1.60) and an increased risk of second invasive cancer event (HR T1 vs. T2 = 1.25; 95% CI = 1.06-1.47). Silhouettes at various ages were not associated with survival. Our results suggest that the evolution of body size from childhood to adulthood has a long-term influence on breast cancer survival. Although these results need to be confirmed, this work sheds light on the need to combine lifelong approaches to current BMI to better identify breast cancer survivors who are at higher risk of recurrence or second primary cancer, or of death. © 2017 UICC.

  2. Extensions of the 3-dimensional plasma transport code E3D

    International Nuclear Information System (INIS)

    Runov, A.; Schneider, R.; Kasilov, S.; Reiter, D.

    2004-01-01

    One important aspect of modern fusion research is plasma edge physics. Fluid transport codes extending beyond the standard 2-D code packages like B2-Eirene or UEDGE are under development. A 3-dimensional plasma fluid code, E3D, based upon the Multiple Coordinate System Approach and a Monte Carlo integration procedure has been developed for general magnetic configurations including ergodic regions. These local magnetic coordinates lead to a full metric tensor which accurately accounts for all transport terms in the equations. Here, we discuss new computational aspects of the realization of the algorithm. The main limitation to the Monte Carlo code efficiency comes from the restriction on the parallel jump of advancing test particles which must be small compared to the gradient length of the diffusion coefficient. In our problems, the parallel diffusion coefficient depends on both plasma and magnetic field parameters. Usually, the second dependence is much more critical. In order to allow long parallel jumps, this dependence can be eliminated in two steps: first, the longitudinal coordinate x 3 of local magnetic coordinates is modified in such a way that in the new coordinate system the metric determinant and contra-variant components of the magnetic field scale along the magnetic field with powers of the magnetic field module (like in Boozer flux coordinates). Second, specific weights of the test particles are introduced. As a result of increased parallel jump length, the efficiency of the code is about two orders of magnitude better. (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  3. E3 Ubiquitin Ligase RNF125 Activates Interleukin-36 Receptor Signaling and Contributes to Its Turnover.

    Science.gov (United States)

    Saha, Siddhartha S; Caviness, Gary; Yi, Guanghui; Raymond, Ernest L; Mbow, M Lamine; Kao, C Cheng

    2018-01-01

    Signaling by the interleukin-36 receptor (IL-36R) is linked to inflammatory diseases such as psoriasis. However, the regulation of IL-36R signaling is poorly understood. Activation of IL-36R signaling in cultured cells results in an increased polyubiquitination of the receptor subunit, IL-1Rrp2. Treatment with deubiquitinases shows that the receptor subunit of IL-36R, IL-1Rrp2, is primarily polyubiquitinated at the K63 position, which is associated with endocytic trafficking and signal transduction. A minor amount of ubiquitination is at the K48 position that is associated with protein degradation. A focused siRNA screen identified RNF125, an E3 ubiquitin ligase, to ubiquitinate IL-1Rrp2 upon activation of IL-36R signaling while not affecting the activated IL-1 receptor. Knockdown of RNF125 decreases signal transduction by the IL-36R. Overexpression of RNF125 in HEK293T cells activates IL-36R signaling and increases the ubiquitination of IL-1Rrp2 and its subsequent turnover. RNF125 can coimmunoprecipitate with the IL-36R, and it traffics with IL-1Rrp2 from the cell surface to lysosomes. Mutations of Lys568 and Lys569 in the C-terminal tail of IL-1Rrp2 decrease ubiquitination by RNF125 and increase the steady-state levels of IL-1Rrp2. These results demonstrate that RNF125 has multiple regulatory roles in the signaling, trafficking, and turnover of the IL-36R. © 2017 S. Karger AG, Basel.

  4. Shutdown of interferon signaling by a viral-hijacked E3 ubiquitin ligase

    Directory of Open Access Journals (Sweden)

    Kaitlin A. Davis

    2017-11-01

    Full Text Available Viruses manipulate cellular processes to create an environment favorable to replication. For most viruses, this includes subverting the expression of interferon (IFN, a signaling molecule that can stimulate production of a vast array of antiviral gene products. Rotavirus, a segmented double-stranded RNA virus that causes acute gastroenteritis in infants and young children, inhibits IFN expression through its nonstructural protein NSP1. This viral protein stifles IFN expression by inducing the degradation of host factors that are necessary for upregulating the activity of IFN genes. In the case of nearly all human and porcine rotavirus strains, NSP1 induces the ubiquitination-dependent proteasomal degradation of β-transducin repeat containing protein (β-TrCP, a host factor that plays an essential role in activating the IFN-transcription factor, NF-κB. Key to the process is the presence of a decoy sequence (degron at the C-terminus of NSP1 that causes β-TrCP to mistakenly bind NSP1 instead of its natural target, inhibitor-of-κB (IκB. In a recent report published by Davis et al [2017; mBio 8(4: e01213-17], we describe molecular requirements that govern NSP1 recognition of β-TrCP, including an essential degron phosphorylation event, and the step-wise incorporation of NSP1 into hijacked cullin-RING E3 ligases (CRLs that ubiquitinate and tag β-TrCP for degradation. Notably, although β-TrCP is chiefly recognized for its role as a master regulator of NF-κB signaling and IFN expression, β-TrCP also controls the stability of checkpoint proteins implicated in numerous other cellular pathways with antiviral activities, including autophagy and apoptosis. Thus, the impact of NSP1 on creating an intracellular environment favorable to virus replication may extend well beyond the IFN signaling pathway.

  5. Analysis of the geomorphology surrounding the Chang'e-3 landing site

    Science.gov (United States)

    Li, Chun-Lai; Mu, Ling-Li; Zou, Xiao-Duan; Liu, Jian-Jun; Ren, Xin; Zeng, Xing-Guo; Yang, Yi-Man; Zhang, Zhou-Bin; Liu, Yu-Xuan; Zuo, Wei; Li, Han

    2014-12-01

    Chang'e-3 (CE-3) landed on the Mare Imbrium basin in the east part of Sinus Iridum (19.51°W, 44.12°N), which was China's first soft landing on the Moon and it started collecting data on the lunar surface environment. To better understand the environment of this region, this paper utilizes the available high-resolution topography data, image data and geological data to carry out a detailed analysis and research on the area surrounding the landing site (Sinus Iridum and 45 km×70 km of the landing area) as well as on the topography, landform, geology and lunar dust of the area surrounding the landing site. A general topographic analysis of the surrounding area is based on a digital elevation model and digital elevation model data acquired by Chang'e-2 that have high resolution; the geology analysis is based on lunar geological data published by USGS; the study on topographic factors and distribution of craters and rocks in the surrounding area covering 4 km×4 km or even smaller is based on images from the CE-3 landing camera and images from the topographic camera; an analysis is done of the effect of the CE-3 engine plume on the lunar surface by comparing images before and after the landing using data from the landing camera. A comprehensive analysis of the results shows that the landing site and its surrounding area are identified as typical lunar mare with flat topography. They are suitable for maneuvers by the rover, and are rich in geological phenomena and scientific targets, making it an ideal site for exploration.

  6. TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase

    International Nuclear Information System (INIS)

    Kallijaervi, Jukka; Lahtinen, Ulla; Haemaelaeinen, Riikka; Lipsanen-Nyman, Marita; Palvimo, Jorma J.; Lehesjoki, Anna-Elina

    2005-01-01

    Mulibrey nanism is an autosomal recessive prenatal-onset growth disorder characterized by dysmorphic features, cardiomyopathy, and hepatomegaly. Mutations in TRIM37 encoding a tripartite motif (TRIM, RING-B-box-coiled-coil)-family protein underlie mulibrey nanism. We investigated the ubiquitin ligase activity predicted for the RING domain of TRIM37 by analyzing its autoubiquitination. Full-length TRIM37 and its TRIM domain were highly polyubiquitinated when co-expressed with ubiquitin. Polyubiquitination was decreased in a mutant protein with disrupted RING domain (Cys35Ser;Cys36Ser) and in the Leu76Pro mutant protein, a disease-associated missense mutation affecting the TRIM domain of TRIM37. Bacterially produced GST-TRIM domain fusion protein, but not its Cys35Ser;Cys36Ser or Leu76Pro mutants, were polyubiquitinated in cell-free conditions, implying RING-dependent modification. Ubiquitin was also identified as an interaction partner for TRIM37 in a yeast two-hybrid screen. Ectopically expressed TRIM37 rapidly formed aggregates that were ubiquitin-, proteasome subunit-, and chaperone-positive in immunofluorescence analysis, defining them as aggresomes. The Cys35Ser;Cys36Ser mutant and the Leu76Pro and Gly322Val patient mutant proteins were markedly less prone to aggregation, implying that aggresomal targeting reflects a physiological function of TRIM37. These findings suggest that TRIM37 acts as a TRIM domain-dependent E3 ubiquitin ligase and imply defective ubiquitin-dependent degradation of an as-yet-unidentified target protein in the pathogenesis of mulibrey nanism

  7. Specific IgE for Fag e 3 Predicts Oral Buckwheat Food Challenge Test Results and Anaphylaxis: A Pilot Study.

    Science.gov (United States)

    Yanagida, Noriyuki; Sato, Sakura; Maruyama, Nobuyuki; Takahashi, Kyohei; Nagakura, Ken-Ichi; Ogura, Kiyotake; Asaumi, Tomoyuki; Ebisawa, Motohiro

    2018-01-01

    Buckwheat (BW) is the source of a life-threatening allergen. Fag e 3-specific serum IgE (sIgE) is more useful than BW-sIgE for diagnosis; however, it is unknown whether Fag e 3-sIgE can predict oral food challenge (OFC) results and anaphylaxis. This study aimed to clarify the efficacy of Fag e 3-sIgE in predicting OFC results and anaphylaxis. We conducted a retrospective review of BW- and Fag e 3-sIgE data obtained using the ImmunoCAP® assay system and fluorescent enzyme-linked immunosorbent assay from children who underwent OFC using 3,072 mg of BW protein between July 2006 and March 2014 at Sagamihara National Hospital, Kanagawa, Japan. We analyzed 60 patients aged 1.9-13.4 years (median 6.0 years); 20 (33%) showed objective symptoms upon BW OFC. The patients without symptoms had significantly lower Fag e 3-sIgE than those with non-anaphylactic (p tested factor that significantly predicted positive OFC results (odds ratio 8.93, 95% confidence interval 3.10-25.73, p < 0.001) and OFC-induced anaphylaxis (2.67, 1.12-6.35, p = 0.027). We suggest that a threshold Fag e 3-sIgE level of 18.0 kUE/L has 95% probability of provoking a positive reaction to BW. Fag e 3-sIgE predicted OFC results and OFC-induced anaphylaxis. We further emphasize paying careful attention to the risk of BW OFC-induced anaphylaxis. © 2018 The Author(s) Published by S. Karger AG, Basel.

  8. Rock mass classification system : transition from RMR to GSI.

    Science.gov (United States)

    2013-11-01

    The AASHTO LRFD Bridge Design Specifications is expected to replace the rock mass rating : (RMR) system with the Geological Strength Index (GSI) system for classifying and estimating : engineering properties of rock masses. This transition is motivat...

  9. Transit space

    DEFF Research Database (Denmark)

    Raahauge, Kirsten Marie

    2008-01-01

    This article deals with representations of one specific city, Århus, Denmark, especially its central district. The analysis is based on anthropological fieldwork conducted in Skåde Bakker and Fedet, two well-off neighborhoods. The overall purpose of the project is to study perceptions of space...... and the interaction of cultural, social, and spatial organizations, as seen from the point of view of people living in Skåde Bakker and Fedet. The focus is on the city dwellers’ representations of the central district of Århus with specific reference to the concept of transit space. When applied to various Århusian...

  10. Transition region

    International Nuclear Information System (INIS)

    Jordan, C.

    1977-01-01

    The Glossary is designed to be a technical dictionary that will provide solar workers of various specialties, students, other astronomers and theoreticians with concise information on the nature and the properties of phenomena of solar and solar-terrestrial physics. Each term, or group of related terms, is given a concise phenomenological and quantitative description, including the relationship to other phenomena and an interpretation in terms of physical processes. The references are intended to lead the non-specialist reader into the literature. This section deals with: transition region; di-electronic recombination; intersystem or intercombination lines; satellite lines; grazing-incidence optics; and crystal spectrometers. (B.R.H.)

  11. Compressive and flexural strength of high strength phase change mortar

    Science.gov (United States)

    Qiao, Qingyao; Fang, Changle

    2018-04-01

    High-strength cement produces a lot of hydration heat when hydrated, it will usually lead to thermal cracks. Phase change materials (PCM) are very potential thermal storage materials. Utilize PCM can help reduce the hydration heat. Research shows that apply suitable amount of PCM has a significant effect on improving the compressive strength of cement mortar, and can also improve the flexural strength to some extent.

  12. Synthesis, spectroscopic characterization, theoretical study and anti-hepatic cancer activity study of 4-(1E,3Z,6E)-3-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-5-oxohepta-1,3,6-trien-1-yl)-2-methoxyphenyl 4-nitrobenzoate, a novel curcumin congener

    Science.gov (United States)

    Srivastava, Sangeeta; Gupta, Preeti; Singh, Ranvijay Pratap; Jafri, Asif; Arshad, M.; Banerjee, Monisha

    2017-08-01

    In the present work 4-(1E,3Z,6E)-3-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-5-oxohepta-1,3,6-trien-1-yl)-2-methoxyphenyl 4-nitrobenzoate (2), a novel curcumin ester was synthesized. The molecular structure and spectroscopic analysis were performed using experimental techniques like FT-IR, 1H,13C NMR, mass and UV-visible as well as theoretical calculations. The theoretical calculations were done by DFT level of theory using B3LYP/6-31G (d,p) basis set. The vibrational wavenumbers were calculated using DFT method and assigned with the help of potential energy distribution (PED). The electronic properties such as frontier orbitals and band gap energies have been calculated using time dependent density functional theory (TD-DFT). The strength and nature of weak intramolecular interactions have been studied by AIM approach. Global and local reactivity descriptors have been computed to predict reactivity and reactive sites in the molecule. First hyperpolarizability values have been calculated to describe the nonlinear optical (NLO) property of the synthesized compounds. Molecular electrostatic potential (MEP) analysis has also been carried out. The anti-hepatic cancer activity of compound 2 was also carried out.

  13. Plutonium-burn high temperature gas-cooled reactor for 3E+3S

    International Nuclear Information System (INIS)

    Okamoto, Koji

    2015-01-01

    . Plutonium can not be extracted from the YSZ-PuO 2 fuel. Therefore, the fuel cannot be used for fuel cycle. However, the direct disposal fuel will be safe in view points of non-proliferation. Nobody can use the Pu spent fuel. The HTGR is superior in viewpoint of 2S, security and safeguards. The Pu-burn HTGR is the solution for Nuclear Energy under 3E+3S. (author)

  14. Institutional Strength in Depth

    International Nuclear Information System (INIS)

    Weightman, M.

    2016-01-01

    Much work has been undertaken in order to identify, learn and implement the lessons from the TEPCO Fukushima Daiichi nuclear accident. These have mainly targeted on engineering or operational lessons. Less attention has been paid to the institutional lessons, although there have been some measures to improve individual peer reviews, particularly by the World Association of Nuclear Operators, and the authoritative IAEA report published in 2015 brought forward several important lessons for regulators and advocated a system approach. The report noted that one of the contributing factors the accident was the tendency of stakeholders not to challenge. Additionally, it reported deficiencies in the regulatory authority and system. Earlier, the root cause of the accident was identified by a Japanese independent parliamentary report as being cultural and institutional. The sum total of the institutions, the safety system, was ineffective. While it is important to address the many technical and operational lessons these may not necessary address this more fundamental lesson, and may not serve to provide robust defences against human or institutional failings over a wide variety of possible events and combinations. The overall lesson is that we can have rigorous and comprehensive safety standards and other tools in place to deliver high levels of safety, but ultimately what is important is the ability of the nuclear safety system to ensure that the relevant institutions diligently and effectively apply those standards and tools — to be robust and resilient. This has led to the consideration of applying the principles of the strength in depth philosophy to a nuclear safety system as a way of providing a framework for developing, assessing, reviewing and improving the system. At an IAEA conference in October 2013, a model was presented for a robust national nuclear safety system based on strength in depth philosophy. The model highlighted three main layers: industry, the

  15. E3B1/ABI-1 Isoforms Are Down-Regulated in Cancers of Human Gastrointestinal Tract

    Directory of Open Access Journals (Sweden)

    Rafia A. Baba

    2012-01-01

    Full Text Available The expression of E3B1/ABI-1 protein and its role in cancer progression and prognosis are largely unknown in the majority of solid tumors. In this study, we examined the expression pattern of E3B1/ABI-1 protein in histologically confirmed cases of esophageal (squamous cell carcinoma and adenocarcinoma, gastro-esophageal junction, colorectal cancers and corresponding normal tissues freshly resected from a cohort of 135 patients, by Western Blotting and Immunofluorescence Staining. The protein is present in its phosphorylated form in cells and tissues. Depending on the extent of phosphorylation it is either present in hyper-phosphorylated (M. Wt. 72 kDa form or in hypo-phosphorylated form (M. Wt. 68 kDa and 65 kDa. A thorough analysis revealed that expression of E3B1/ABI-1 protein is significantly decreased in esophageal, gastro-esophageal junction and colorectal carcinomas irrespective of age, gender, dietary and smoking habits of the patients. The decrease in expression of E3B1/ABI-1 was consistently observed for all the three isoforms. However, the decrease in the expression of isoforms varied with different forms of cancers. Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis.

  16. Transitional issues

    International Nuclear Information System (INIS)

    1998-01-01

    This discussion paper, the fifth in the series developed at the IPPSO Market Design Conference, addressed the issue of the need to prevent Ontario Hydro from taking unfair advantage of independent producers and other stakeholders through activities and investments in new power generating capacity in the transitional period leading up to deregulation. The need for controls is predicated on the assumption that the short-term actions and investments of Ontario Hydro could seriously compromise the position of independent generators, and that without such controls the level playing field essential to the operation of a competitive market, does not exist. Various actual and potential actions of Ontario Hydro were discussed, all of which point to the need for strict controls over Ontario Hydro exercising its dominant market power in an unfair way. It was recommended that as a minimum, the provincial government should no longer provide guarantees for Ontario Hydro capital projects, and that Ontario Hydro be instructed to defer any investment on new or returning generating capacity until the new market is in place. Limits could also be placed on Ontario Hydro's marketing efforts to enter into contracts during the transition period, and Ontario Hydro and municipal utilities should be required to keep separate accounts of their commercial preparation, and to settle such accounts separate from ratepayer revenue

  17. Improving Parolees' Participation in Drug Treatment and Other Services through Strengths Case Management

    OpenAIRE

    Prendergast, Michael; Cartier, Jerome J.

    2008-01-01

    In an effort to increase participation in community aftercare treatment for substance-abusing parolees, an intervention based on a transitional case management (TCM) model that focuses mainly on offenders' strengths has been developed and is under testing. This model consists of completion, by the inmate, of a self-assessment of strengths that informs the development of the continuing care plan, a case conference call shortly before release, and strengths case management for three months post...

  18. Comments on the electroweak phase transition

    International Nuclear Information System (INIS)

    Dine, M.; Leigh, R.G.; Huet, P.; Linde, A.; Linde, D.

    1992-01-01

    We report on an investigation of various problems related to the theory of the electroweak phase transition. This includes a determination of the nature of the phase transition, a discussion of the possible role of higher order radiative corrections and the theory of the formation and evolution of the bubbles of the new phase. We find in particular that no dangerous linear terms appear in the effective potential. However, the strength of the first-order phase transition is 2/3 times less than what follows from the one-loop approximation. This rules out baryogenesis in the minimal version of the electroweak theory with light Higgs bosons. (orig.)

  19. Atomic final-state effects in nuclear transitions

    International Nuclear Information System (INIS)

    Griffiths, A.; Vogel, P.

    1991-01-01

    The interaction of a nuclear gamma radiation with the atomic electron cloud gives rise to a phase shift in the nuclear electromagnetic transition amplitude. The resulting interference parameters ξ(πL) are of significance to the analysis of time-reversal experiments. We calculate these parameters for E1, E2, E3, M1, and M2 gamma transitions in a number of nuclei. We also discuss the implication of these results for simultaneous parity- and time-reversal-violating experiments

  20. Global Energy-Economy-Environment (E3) Scenarios to 2050 and Beyond

    International Nuclear Information System (INIS)

    Schrattenholzer, L.

    2005-01-01

    The Environmentally Compatible Energy Strategies (ECS) Program at the International Institute for Applied Systems Analysis (IIASA) develops policy-relevant global and world-regional energy perspectives. The basic premise of the ECS's research program is a global trend of d ecarbonization . Firstly, decarbonization includes a trend toward ever-greater efficiency, or ever less waste, in society's use of energy resources. Secondly, it includes a trend towards less carbon-intensive fossil fuels (e.g., from coal toward natural gas) and, further, to non-fossil fuels, especially renewable energy carriers. Technological change is generally regarded as one of the key drivers of sustained economic growth. Long-term energy scenarios developed at IIASA and elsewhere show that, depending on key assumptions on drivers such as population, economic growth and technological development, global energy development can be environmentally unsustainable. First, energy development might not lead to stabilizing greenhouse concentrations and might thus have significant negative impacts on the global climate. In addition, some, especially coal-intensive, scenarios might lead to levels of acid deposition at which significant damage to sensitive ecosystems is expected to occur in Europe and, even more so, in Asia. A continuation of the observed historical long-term trends of decarbonization, dematerialization, and energy efficiency improvements might therefore not be sufficient to achieve sustainable growth. Targeted technological development aiming at accelerating decarbonization, dematerialization, and/or efficiency improvement may be one of the most effective means for reconciling economic growth with global environmental objectives. This might require a step-up in investments in R and D and in the demonstration of technologies so as to stimulate both learning-by-searching and learning-by-doing. In this presentation, global E3 scenarios will be summarized in the following three groups: Non

  1. Energy transition

    International Nuclear Information System (INIS)

    Anon.

    2013-01-01

    The yearly environmental conference will hold on September 2013 to evaluate the negotiations led at the national and local levels for december 2012. The government will have then to decide of an energy programming bill which will be submitted to the Parliament at the beginning of the year 2014. 30 main propositions have emerged of the decentralised debates. One of them is the ecological taxation which raise the question of the gas oil and petrol taxation. The current environmental taxes are for almost three quarters of them taxes on energy consumptions and mainly on fossil energies. The Economic, Social and Environmental Council, gives his opinion on the way to find resources to ensure the ecological and energy transition while reducing the public deficit of the State. (O.M.)

  2. Rapid Communication: v= 2 seniority changing transitions in yrast 3 ...

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 89; Issue 5. Rapid Communication: Δ υ = 2 seniority changing transitions in yrast 3 − states and B ( E 3 ) systematics of Sn isotopes. BHOOMIKA MAHESHWARI SWATI GARG ASHOK KUMAR JAIN. Research Article Volume 89 Issue 5 November 2017 Article ID 75 ...

  3. Loading Conditions and Longitudinal Strength

    DEFF Research Database (Denmark)

    Sørensen, Herman

    1995-01-01

    Methods for the calculation of the lightweight of the ship.Loading conditions satisfying draught, trim and intact stability requirements and analysis of the corresponding stillwater longitudinal strength.......Methods for the calculation of the lightweight of the ship.Loading conditions satisfying draught, trim and intact stability requirements and analysis of the corresponding stillwater longitudinal strength....

  4. ASD Transition to Mainstream Secondary: A Positive Experience?

    Science.gov (United States)

    Neal, Sinead; Frederickson, Norah

    2016-01-01

    The transition to secondary school is considered difficult for children with autistic spectrum disorder (ASD), yet there has been little strength-based investigation of positive experiences of this population and the types of support they value most in managing anxiety about transition. The current article presents a qualitative exploration of the…

  5. Effects of dietary fish oil on serum lipids and VLDL kinetics in hyperlipidemic apolipoprotein E*3-Leiden transgenic mice

    NARCIS (Netherlands)

    Vlijmen, B.J.M. van; Mensink, R.P.; Hof, H.B. van 't; Offermans, R.F.G.; Hofker, M.H.; Havekes, L.M.

    1998-01-01

    Studying the effects of dietary fish oil on VLDL metabolism in humans is subject to both large intra- and interindividual variability. In the present study we therefore used hyperlipidentic apolipoprotein (APO) E*3-Leiden mice, which have impaired chylomicron and very low density lipoprotein (VDL)

  6. X-Ray and optical study of low core density globular clusters NGC6144 and E3

    NARCIS (Netherlands)

    Lan, S.-H.; Kong, A.K.H.; Verbunt, F.W.M.; Lewin, W.H.G.; Bassa, C.G.; Anderson, S.F.; Pooley, D.

    2010-01-01

    We report on the Chandra X-ray Observatory and Hubble Space Telescope (HST) observations of two low coredensity globular clusters, NGC6144 and E3. By comparing the number of X-ray sources inside the half-mass radius to those outside, we found six X-ray sources within the half-mass radius of NGC6144,

  7. Phosphorylation in vitro of eukaryotic initiation factors IF-E2 and IF-E3 by protein kinases

    DEFF Research Database (Denmark)

    Issinger, O G; Benne, R; Hershey, J W

    1976-01-01

    Purified protein synthesis initiation factors IF-E2 and IF-E3 from rabbit reticulocytes were phosphorylated in vitro with protein kinases isolated from the same source. The highest levels of phosphorylation resulted from incubation of the factors with a cyclic nucleotide-independent protein kinase...

  8. STRENGTH OF NANOMODIFIED HIGH-STRENGTH LIGHTWEIGHT CONCRETES

    Directory of Open Access Journals (Sweden)

    NOZEMTСEV Alexandr Sergeevich

    2013-02-01

    Full Text Available The paper presents the results of research aimed at development of nanomodified high-strength lightweight concrete for construction. The developed concretes are of low average density and high ultimate compressive strength. It is shown that to produce this type of concrete one need to use hollow glass and aluminosilicate microspheres. To increase the durability of adhesion between cement stone and fine filler the authors offer to use complex nanodimensinal modifier based on iron hydroxide sol and silica sol as a surface nanomodifier for hollow microspheres. It is hypothesized that the proposed modifier has complex effect on the activity of the cement hydration and, at the same time increases bond strength between filler and cement-mineral matrix. The compositions for energy-efficient nanomodified high-strength lightweight concrete which density is 1300…1500 kg/m³ and compressive strength is 40…65 MPa have been developed. The approaches to the design of high-strength lightweight concrete with density of less than 2000 kg/m³ are formulated. It is noted that the proposed concretes possess dense homogeneous structure and moderate mobility. Thus, they allow processing by vibration during production. The economic and practical implications for realization of high-strength lightweight concrete in industrial production have been justified.

  9. Relativistic configuration interaction treatment of generalized oscillator strength for krypton

    International Nuclear Information System (INIS)

    Wang Huangchun; Qu Yizhi; Liu Chunhua

    2007-01-01

    A fully relativistic configuration interaction method is developed to investigate the transition energies and general oscillator strengths of the lower lying states of krypton, for both optically allowed and optically forbidden transitions. The calculated results are in agreement with the recent experimental measurements. The calculated transition energies for the 5s and 5s' transitions are 9.970 and 10.717 eV, which agree with the experimental data of 10.033 and 10.643 eV. The calculated oscillator strengths are 0.211 and 0.170, comparable with the experimental results 0.214(±0.012) and 0.194 (±0.012), respectively. The momentum transfer positions (K 2 in a.u.) of the minimum and maximum GOSs in the 4s 2 4p 6 →4s 2 4p 5 (5s + 5s') transitions are 1.105 and 2.225, comparable with the measurements results 1.24 and 2.97. (authors)

  10. Relativistic Configuration Interaction Treatment of Generalized Oscillator Strength for Krypton

    Institute of Scientific and Technical Information of China (English)

    WANG Huang-Chun; QU Yi-Zhi; LIU Chun-Hua

    2007-01-01

    A fully relativistic configuration interaction method is developed to investigate the transition energies and general oscillator strengths of the lower lying states of krypton, for both optically allowed and optically forbidden transitions. The calculated results are in agreement with the recent experimental measurements. The calculated transition energies for the 5s and 5s' transitions are 9.970 and 10.717eV, which agree with the experimental data of 10.033 and 10.643 eV. The calculated oscillator strengths are 0.211 and 0.170, comparable with the experimental results 0.214(±0.012) and 0.194 (±0.012), respectively. The momentum transfer positions ( K2 in a.u.) of the minimum and maximum GOSs in the 4s24p6 → 4s24p5 (5s + 5s') transitions are 1.105 and 2.225, comparable with the measurements results 1.24 and 2.97 [Phys. Rev. A 67 (2003) 062708].

  11. A role for non-covalent SUMO interaction motifs in Pc2/CBX4 E3 activity.

    Directory of Open Access Journals (Sweden)

    Jacqueline C Merrill

    2010-01-01

    Full Text Available Modification of proteins by the small ubiquitin like modifier (SUMO is an essential process in mammalian cells. SUMO is covalently attached to lysines in target proteins via an enzymatic cascade which consists of E1 and E2, SUMO activating and conjugating enzymes. There is also a variable requirement for non-enzymatic E3 adapter like proteins, which can increase the efficiency and specificity of the sumoylation process. In addition to covalent attachment of SUMO to target proteins, specific non-covalent SUMO interaction motifs (SIMs that are generally short hydrophobic peptide motifs have been identified.Intriguingly, consensus SIMs are present in most SUMO E3s, including the polycomb protein, Pc2/Cbx4. However, a role for SIMs in SUMO E3 activity remains to be shown. We show that Pc2 contains two functional SIMs, both of which contribute to full E3 activity in mammalian cells, and are also required for sumoylation of Pc2 itself. Pc2 forms distinct sub-nuclear foci, termed polycomb bodies, and can recruit partner proteins, such as the corepressor CtBP. We demonstrate that mutation of the SIMs in Pc2 prevents Pc2-dependent CtBP sumoylation, and decreases enrichment of SUMO1 and SUMO2 at polycomb foci. Furthermore, mutational analysis of both SUMO1 and SUMO2 reveals that the SIM-interacting residues of both SUMO isoforms are required for Pc2-mediated sumoylation and localization to polycomb foci.This work provides the first clear evidence for a role for SIMs in SUMO E3 activity.

  12. RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases

    Science.gov (United States)

    Lin, Yi-Han; Evans, Timothy R.; Doms, Alexandra G.; Beauchene, Nicole A.; Hierro, Aitor

    2018-01-01

    The eukaryotic ubiquitylation machinery catalyzes the covalent attachment of the small protein modifier ubiquitin to cellular target proteins in order to alter their fate. Microbial pathogens exploit this post-translational modification process by encoding molecular mimics of E3 ubiquitin ligases, eukaryotic enzymes that catalyze the final step in the ubiquitylation cascade. Here, we show that the Legionella pneumophila effector protein RavN belongs to a growing class of bacterial proteins that mimic host cell E3 ligases to exploit the ubiquitylation pathway. The E3 ligase activity of RavN was located within its N-terminal region and was dependent upon interaction with a defined subset of E2 ubiquitin-conjugating enzymes. The crystal structure of the N-terminal region of RavN revealed a U-box-like motif that was only remotely similar to other U-box domains, indicating that RavN is an E3 ligase relic that has undergone significant evolutionary alteration. Substitution of residues within the predicted E2 binding interface rendered RavN inactive, indicating that, despite significant structural changes, the mode of E2 recognition has remained conserved. Using hidden Markov model-based secondary structure analyses, we identified and experimentally validated four additional L. pneumophila effectors that were not previously recognized to possess E3 ligase activity, including Lpg2452/SdcB, a new paralog of SidC. Our study provides strong evidence that L. pneumophila is dedicating a considerable fraction of its effector arsenal to the manipulation of the host ubiquitylation pathway. PMID:29415051

  13. Collision strengths and oscillator strengths for excitation to the n = 3 and 4 levels of neon-like ions

    International Nuclear Information System (INIS)

    Zhang, H.; Sampson, D.H.; Clark, R.E.H.; Mann, J.B.

    1987-01-01

    Collision strengths are given for the 88 possible fine-structure transitions between the ground level and the n = 3 and 4 levels in 20 neon-like ions with nuclear charge number Z in the range 18 ≤Z≤74. The results are given for the nine impact-electron energies in threshold units X = 1.0, 1.2, 1.5, 1.9, 2.5, 4.0, 6.0, 10.0, and 15.0. In addition, electric dipole oscillator strengths obtained by various methods are given. copyright 1987 Academic Press, Inc

  14. Quadrupole decay strength of the M1 scissors mode

    Science.gov (United States)

    Beck, T.; Beller, J.; Derya, V.; Gayer, U.; Isaak, J.; Löher, B.; Mertes, L.; Pietralla, N.; Ries, P.; Romig, C.; Savran, D.; Scheck, M.; Tornow, W.; Weller, H. R.; Werner, V.; Zweidinger, M.

    2015-10-01

    The E2/M1 multipole mixing ratio δ1→2 of the 1sc +→21+ transition of Gd was determined using results from high-statistics photon scattering. This provides a possibility for a new approach on the search of Jsc + members of the rotational band built on the scissors mode. By application of Alaga's rule, which is justifiable as 156Gd is a well-deformed rotor with good K quantum number, a transition strength of B (E 2 ;2sc +→01+)=0.034 (13 ) W.u. is estimated.

  15. Scaling behavior in first-order quark-hadron phase transition

    International Nuclear Information System (INIS)

    Hwa, R.C.

    1994-01-01

    It is shown that in the Ginzburg-Landau description of first-order quark-hadron phase transition the normalized factorial moments exhibit scaling behavior. The scaling exponent ν depends on only one effective parameter g, which characterizes the strength of the transition. For a strong first-order transition, we find ν=1.45. For weak transition it is 1.30 in agreement with the earlier result on second-order transition

  16. A Multi-Phase Equation of State and Strength Model for Tin

    International Nuclear Information System (INIS)

    Cox, G. A.

    2006-01-01

    This paper considers a multi-phase equation of state and a multi-phase strength model for tin in the β, γ and liquid phases. At a phase transition there are changes in volume, energy, and properties of a material that should be included in an accurate model. The strength model will also be affected by a solid-solid phase transition. For many materials there is a lack of experimental data for strength at high pressures making the derivation of strength parameters for some phases difficult. In the case of tin there are longitudinal sound speed data on the Hugoniot available that have been used here in conjunction with a multi-phase equation of state to derive strength parameters for the γ phase, a phase which does not exist at room temperature and pressure

  17. Atomic Transition Probabilities Scandium through Manganese

    International Nuclear Information System (INIS)

    Martin, G.A.; Fuhr, J.R.; Wiese, W.L.

    1988-01-01

    Atomic transition probabilities for about 8,800 spectral lines of five iron-group elements, Sc(Z = 21) to Mn(Z = 25), are critically compiled, based on all available literature sources. The data are presented in separate tables for each element and stage of ionization and are further subdivided into allowed (i.e., electric dipole-E1) and forbidden (magnetic dipole-M1, electric quadrupole-E2, and magnetic quadrupole-M2) transitions. Within each data table the spectral lines are grouped into multiplets, which are in turn arranged according to parent configurations, transition arrays, and ascending quantum numbers. For each line the transition probability for spontaneous emission and the line strength are given, along with the spectroscopic designation, the wavelength, the statistical weights, and the energy levels of the upper and lower states. For allowed lines the absorption oscillator strength is listed, while for forbidden transitions the type of transition is identified (M1, E2, etc.). In addition, the estimated accuracy and the source are indicated. In short introductions, which precede the tables for each ion, the main justifications for the choice of the adopted data and for the accuracy rating are discussed. A general introduction contains a discussion of our method of evaluation and the principal criteria for our judgements

  18. Biochemical function of typical and variant Arabidopsis thaliana U-box E3 ubiquitin-protein ligases.

    Science.gov (United States)

    Wiborg, Jakob; O'Shea, Charlotte; Skriver, Karen

    2008-08-01

    The variance of the U-box domain in 64 Arabidopsis thaliana (thale cress) E3s (ubiquitin-protein ligases) was used to examine the interactions between E3s and E2s (ubiquitin-conjugating enzymes). E2s and E3s are components of the ubiquitin protein degradation pathway. Seven U-box proteins were analysed for their ability to ubiquitinate proteins in vitro in co-operation with different E2s. All U-box domains exhibited ubiquitination activity and interacted productively with UBC4/5-type E2s. Three and four of the U-box domains mediated ubiquitin addition in the presence of UBC13 and UBC7 E2s respectively, but no productive interaction was observed with the UBC15 E2 tested. The activity of AtPUB54 [Arabidopsis thaliana (thale cress) plant U-box 54 protein] was dependent on Trp(266) in the E2-binding cleft, and the E2 selectivity was changed by substitution of this position. The function of the distant U-box protein, AtPUB49, representing a large family of eukaryotic proteins containing a U-box linked to a cyclophilin-like peptidyl-prolyl cis-trans isomerase domain, was characterized biochemically. AtPUB49 functioned both as a prolyl isomerase and a chaperone by catalysing cis-trans isomerization of peptidyl-prolyl bonds and dissolving protein aggregates. In conclusion, both typical and atypical Arabidopsis U-box proteins were active E3s. The overlap in the E3/E2 selectivity suggests that in vivo specificity is not determined only by the E3-E2 interactions, but also by other parameters, e.g. co-existence or interactions with additional domains. The biochemical functions of AtPUB49 suggest that the protein can be involved in folding or degradation of protein substrates. Similar functions can also be retained within a protein complex with separate chaperone and U-box proteins.

  19. Where is the Scissors Mode Strength in Odd-Mass Nuclei?

    International Nuclear Information System (INIS)

    Enders, J.; Huxel, N.; von Neumann-Cosel, P.; Richter, A.

    1997-01-01

    It is demonstrated by a fluctuation analysis based on the assumption of a Wigner distribution for the nuclear level spacings and of a Porter-Thomas distribution for the transition strengths that significant parts of the dipole strength excited in photon scattering experiments in heavy, deformed odd-mass nuclei are hidden in the background of the experimental spectra. With this additional strength, the heretofore claimed severe reduction of the B(M1) scissors mode strength in odd-mass nuclei compared to the one in neighboring even-even nuclei disappears. copyright 1997 The American Physical Society

  20. Rock strength under explosive loading

    International Nuclear Information System (INIS)

    Rimer, N.; Proffer, W.

    1993-01-01

    This presentation emphasizes the importance of a detailed description of the nonlinear deviatoric (strength) response of the surrounding rock in the numerical simulation of underground nuclear explosion phenomenology to the late times needed for test ban monitoring applications. We will show how numerical simulations which match ground motion measurements in volcanic tuffs and in granite use the strength values obtained from laboratory measurements on small core samples of these rocks but also require much lower strength values after the ground motion has interacted with the rock. The underlying physical mechanisms for the implied strength reduction are not yet well understood, and in fact may depend on the particular rock type. However, constitutive models for shock damage and/or effective stress have been used successfully at S-Cubed in both the Geophysics Program (primarily for DARPA) and the Containment Support Program (for DNA) to simulate late time ground motions measured at NTS in many different rock types

  1. Strength Training and Your Child

    Science.gov (United States)

    ... in organized sports or activities such as baseball, soccer, or gymnastics usually can safely to start strength ... as biking and running, adequate hydration, and healthy nutrition. Reviewed by: Mary L. Gavin, MD Date reviewed: ...

  2. Preliminary Report on Oak Ridge National Laboratory Testing of Drake/ACSS/MA2/E3X

    Energy Technology Data Exchange (ETDEWEB)

    Irminger, Philip [ORNL; Davis, Cody [General Cable Corporation; Temple, Bill [General Cable Corporation; Baker, Gord [General Cable Corporation; Starke, Michael R [ORNL

    2016-01-01

    A key to industry acceptance of a new technology is extensive validation in field trials. The Powerline Conductor Accelerated Test facility (PCAT) at Oak Ridge National Laboratory (ORNL) is specifically designed to evaluate the performance and reliability of a new conductor technology under real world conditions. The facility is set up to capture large amounts of data during testing. General Cable used the ORNL PCAT facility to validate the performance of TransPowr with E3X Technology a standard overhead conductor with an inorganic high emissivity, low absorptivity surface coating. Extensive testing has demonstrated a significant improvement in conductor performance across a wide range of operating temperatures, indicating that E3X Technology can provide a reduction in temperature, a reduction in sag, and an increase in ampacity when applied to the surface of any overhead conductor. This report provides initial results of that testing.

  3. The E-3 Test Facility at Stennis Space Center: Research and Development Testing for Cryogenic and Storable Propellant Combustion Systems

    Science.gov (United States)

    Pazos, John T.; Chandler, Craig A.; Raines, Nickey G.

    2009-01-01

    This paper will provide the reader a broad overview of the current upgraded capabilities of NASA's John C. Stennis Space Center E-3 Test Facility to perform testing for rocket engine combustion systems and components using liquid and gaseous oxygen, gaseous and liquid methane, gaseous hydrogen, hydrocarbon based fuels, hydrogen peroxide, high pressure water and various inert fluids. Details of propellant system capabilities will be highlighted as well as their application to recent test programs and accomplishments. Data acquisition and control, test monitoring, systems engineering and test processes will be discussed as part of the total capability of E-3 to provide affordable alternatives for subscale to full scale testing for many different requirements in the propulsion community.

  4. Characteristics of structural loess strength and preliminary framework for joint strength formula

    OpenAIRE

    Rong-jian Li; Jun-ding Liu; Rui Yan; Wen Zheng; Sheng-jun Shao

    2014-01-01

    The strength of structural loess consists of the shear strength and tensile strength. In this study, the stress path, the failure envelope of principal stress (Kf line), and the strength failure envelope of structurally intact loess and remolded loess were analyzed through three kinds of tests: the tensile strength test, the uniaxial compressive strength test, and the conventional triaxial shear strength test. Then, in order to describe the tensile strength and shear strength of structural lo...

  5. Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice.

    Directory of Open Access Journals (Sweden)

    Chunxiu Hu

    Full Text Available Lipids are known to play crucial roles in the development of life-style related risk factors such as obesity, dyslipoproteinemia, hypertension and diabetes. The first selective cannabinoid-1 receptor blocker rimonabant, an anorectic anti-obesity drug, was frequently used in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/m(2 with associated risk factors such as type II diabetes and dyslipidaemia in the past. Less is known about the impact of this drug on the regulation of lipid metabolism in plasma and liver in the early stage of obesity.We designed a four-week parallel controlled intervention on apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP transgenic mice with mild overweight and hypercholesterolemia. A liquid chromatography-linear ion trap-Fourier transform ion cyclotron resonance-mass spectrometric approach was employed to investigate plasma and liver lipid responses to the rimonabant intervention. Rimonabant was found to induce a significant body weight loss (9.4%, p<0.05 and a significant plasma total cholesterol reduction (24%, p<0.05. Six plasma and three liver lipids in ApoE*3Leiden.CETP transgenic mice were detected to most significantly respond to rimonabant treatment. Distinct lipid patterns between the mice were observed for both plasma and liver samples in rimonabant treatment vs. non-treated controls. This study successfully applied, for the first time, systems biology based lipidomics approaches to evaluate treatment effects of rimonabant in the early stage of obesity.The effects of rimonabant on lipid metabolism and body weight reduction in the early stage obesity were shown to be moderate in ApoE*3Leiden.CETP mice on high-fat diet.

  6. Regolith thickness at the Chang'E-3 landing site from the Lunar Penetrating Radar and impact craters

    Science.gov (United States)

    Fa, W.; Zhu, M.-H.; Liu, T.

    2015-10-01

    The Chang'E-3 lunar penetrating radar (LPR) observations reveal a newly formed regolith layer (<1 m), an ejecta layer (~2-6 m), and a palaeoregolith layer (~4-9 m) from the surface to a depth of ~ 20 m. The thicknesses of the newly formed regolith layer and the palaeoregolith layer are consistent with the estimations based on the excavation depth and morphology of small fresh craters.

  7. Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner

    OpenAIRE

    David, Diana; Jagadeeshan, Sankar; Hariharan, Ramkumar; Nair, Asha Sivakumari; Pillai, Radhakrishna Madhavan

    2014-01-01

    Background Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, Smurf2 regulates a repertoire of other signaling pathways ranging from planar cell polarity during embryonic development to cell proliferation, migration, differentiation and senescence. Expression of Smurf2 is found to be dysregulated in many cancers including breast cancer. Th...

  8. Estimated dietary dioxin exposure and breast cancer risk among women from the French E3N prospective cohort.

    Science.gov (United States)

    Danjou, Aurélie M N; Fervers, Béatrice; Boutron-Ruault, Marie-Christine; Philip, Thierry; Clavel-Chapelon, Françoise; Dossus, Laure

    2015-03-17

    Dioxins are environmental and persistent pollutants mostly emitted from combustion facilities (e.g. waste incinerators, metal and cement industries). Known to be endocrine disrupting chemicals, dioxins are suspected to increase breast cancer (BC) risk. Although diet is considered the primary source of dioxin exposure, no previous study has been published on dietary dioxin exposure in relation to BC risk. We aimed to assess dietary dioxin exposure among women from the E3N cohort and estimate BC risk associated with this exposure. The study included 63,830 women from the E3N cohort who completed a diet history questionnaire (DHQ) in 1993 and were followed until 2008. Dietary dioxin exposure was estimated by combining consumption data from the E3N DHQ and food dioxin contamination data from a French national monitoring program. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox models adjusted for BC risk factors. Mean dietary dioxin exposure was estimated at 1.3 ± 0.4 pg/kg body weight (BW)/day. A 0.4 pg/kg BW/d increase in dioxin intake was not associated with overall BC risk (HR = 1.00; 95% CI: 0.96, 1.05). A significant decrease in risk of estrogen receptor negative (ER-)/progesterone receptor negative (PR-) tumors was observed among post-menopausal women in the upper quartile of estimated dioxin intake (HR for Q4 vs. Q1: 0.65; 95% CI: 0.45, 0.96; P for trend across quartiles = 0.0463). Overall, no association between estimated dietary dioxin exposure and BC risk was found among E3N women. Further studies should include both dietary and environmental exposures to determine whether low-dose dioxin exposure is associated with BC risk.

  9. (E-3-Methyl-6-(3-oxo-3-(thiophen-2-yl-1-propenyl-2(3H-benzothiazolone

    Directory of Open Access Journals (Sweden)

    Yordanka Ivanova

    2016-04-01

    Full Text Available The title compound, (E-3-methyl-6-(3-oxo-3-(thiophen-2-yl-1-propenyl-2(3H-benzothiazolone, was synthesized by Claisen-Schmidt condensation of 3-methyl-2(3H-benzothiazolone-6-carbaldehyde with 2-acetylthiophene in 94% yield. The structure of the target compound was confirmed using 1H-NMR, 13C-NMR, IR, MS, and elemental analysis.

  10. Biochemical function of typical and variant Arabidopsis thaliana U-box E3 ubiquitin-protein ligases

    DEFF Research Database (Denmark)

    Wiborg, Jakob; O'Shea, Charlotte; Skriver, Karen

    2008-01-01

    of the distant U-box protein, AtPUB49, representing a large family of eukaryotic proteins containing a U-box linked to a cyclophilin-like peptidyl-prolyl cis-trans isomerase domain, was characterized biochemically. AtPUB49 functioned both as a prolyl isomerase and a chaperone by catalysing cis......The variance of the U-box domain in 64 Arabidopsis thaliana (thale cress) E3s (ubiquitin-protein ligases) was used to examine the interactions between E3s and E2s (ubiquitin-conjugating enzymes). E2s and E3s are components of the ubiquitin protein degradation pathway. Seven U-box proteins were...... analysed for their ability to ubiquitinate proteins in vitro in co-operation with different E2s. All U-box domains exhibited ubiquitination activity and interacted productively with UBC4/5-type E2s. Three and four of the U-box domains mediated ubiquitin addition in the presence of UBC13 and UBC7 E2s...

  11. Transition sum rules in the shell model

    Science.gov (United States)

    Lu, Yi; Johnson, Calvin W.

    2018-03-01

    An important characterization of electromagnetic and weak transitions in atomic nuclei are sum rules. We focus on the non-energy-weighted sum rule (NEWSR), or total strength, and the energy-weighted sum rule (EWSR); the ratio of the EWSR to the NEWSR is the centroid or average energy of transition strengths from an nuclear initial state to all allowed final states. These sum rules can be expressed as expectation values of operators, which in the case of the EWSR is a double commutator. While most prior applications of the double commutator have been to special cases, we derive general formulas for matrix elements of both operators in a shell model framework (occupation space), given the input matrix elements for the nuclear Hamiltonian and for the transition operator. With these new formulas, we easily evaluate centroids of transition strength functions, with no need to calculate daughter states. We apply this simple tool to a number of nuclides and demonstrate the sum rules follow smooth secular behavior as a function of initial energy, as well as compare the electric dipole (E 1 ) sum rule against the famous Thomas-Reiche-Kuhn version. We also find surprising systematic behaviors for ground-state electric quadrupole (E 2 ) centroids in the s d shell.

  12. Rural Vocational and Transition Assessment Practices for Students with Intellectual Disabilities: What Do Educators Really Know?

    Science.gov (United States)

    Brendle, Janna; Tucker, Kathryn J.; Lock, Robin H.

    2018-01-01

    Transition planning requires quality vocational and transition assessment tailored to the student's needs, strengths, preferences and interests. Limited research is currently available that addresses assessment types and use of results that rural practitioners utilize to aid in transition planning for students with intellectual disabilities (ID).…

  13. Reactive Strength Index: A Poor Indicator of Reactive Strength?

    Science.gov (United States)

    Healy, Robin; Kenny, Ian; Harrison, Drew

    2017-11-28

    The primary aim was to assess the relationships between reactive strength measures and associated kinematic and kinetic performance variables achieved during drop jumps. A secondary aim was to highlight issues with the use of reactive strength measures as performance indicators. Twenty eight national and international level sprinters, consisting of fourteen men and women, participated in this cross-sectional analysis. Athletes performed drop jumps from a 0.3 m box onto a force platform with dependent variables contact time (CT), landing time (TLand), push-off time (TPush), flight time (FT), jump height (JH), reactive strength index (RSI, calculated as JH / CT), reactive strength ratio (RSR, calculated as FT / CT) and vertical leg spring stiffness (Kvert) recorded. Pearson's correlation test found very high to near perfect relationships between RSI and RSR (r = 0.91 to 0.97), with mixed relationships found between RSI, RSR and the key performance variables, (Men: r = -0.86 to -0.71 between RSI/RSR and CT, r = 0.80 to 0.92 between RSI/RSR and JH; Women: r = -0.85 to -0.56 between RSR and CT, r = 0.71 between RSI and JH). This study demonstrates that the method of assessing reactive strength (RSI versus RSR) may be influenced by the performance strategies adopted i.e. whether an athlete achieves their best reactive strength scores via low CTs, high JHs or a combination. Coaches are advised to limit the variability in performance strategies by implementing upper and / or lower CT thresholds to accurately compare performances between individuals.

  14. Astrophysical relevance of γ transition energies

    International Nuclear Information System (INIS)

    Rauscher, Thomas

    2008-01-01

    The relevant γ energy range is explicitly identified where additional γ strength must be located to have an impact on astrophysically relevant reactions. It is shown that folding the energy dependences of the transmission coefficients and the level density leads to maximal contributions for γ energies of 2≤E γ ≤4 unless quantum selection rules allow isolated states to contribute. Under this condition, electric dipole transitions dominate. These findings allow us to more accurately judge the relevance of modifications of the γ strength for astrophysics

  15. Lifting strength in two-person teamwork.

    Science.gov (United States)

    Lee, Tzu-Hsien

    2016-01-01

    This study examined the effects of lifting range, hand-to-toe distance, and lifting direction on single-person lifting strengths and two-person teamwork lifting strengths. Six healthy males and seven healthy females participated in this study. Two-person teamwork lifting strengths were examined in both strength-matched and strength-unmatched groups. Our results showed that lifting strength significantly decreased with increasing lifting range or hand-to-toe distance. However, lifting strengths were not affected by lifting direction. Teamwork lifting strength did not conform to the law of additivity for both strength-matched and strength-unmatched groups. In general, teamwork lifting strength was dictated by the weaker of the two members, implying that weaker members might be exposed to a higher potential danger in teamwork exertions. To avoid such overexertion in teamwork, members with significantly different strength ability should not be assigned to the same team.

  16. E3N, a French cohort study on cancer risk factors. E3N Group. Etude Epidémiologique auprès de femmes de l'Education Nationale.

    Science.gov (United States)

    Clavel-Chapelon, F; van Liere, M J; Giubout, C; Niravong, M Y; Goulard, H; Le Corre, C; Hoang, L A; Amoyel, J; Auquier, A; Duquesnel, E

    1997-10-01

    This paper describes the design of E3N, a prospective cohort study conducted in France on risk factors for female cancers. The cohort comprises 100,000 women, aged 40-65 years at baseline in 1990. Participants were asked to complete questionnaires every 18 months. The main hypotheses studied concern the relationship between diet and cancer and between hormonal treatments and cancer. All cancers diagnosed are registered, together with other diseases (cardiovascular diseases, diabetes, osteoporosis). The study population and the follow-up procedure are described.

  17. Investigations on the tensile strength of high performance concrete incorporating silica fume

    International Nuclear Information System (INIS)

    Santanu Bhanja; Bratish Sengupta

    2005-01-01

    Though the literature is rich in reporting on silica fume concrete the technical data on tensile strength is quite limited. The present paper is directed towards developing a better understanding on the isolated contribution of silica fume on the tensile strengths of High Performance Concrete. Extensive experimentation was carried out over water-binder ratios ranging from 0.26 to 0.42 and silica fume binder ratios from 0.0 to 0.3. For all the mixes compressive, flexural and split tensile strengths were determined at 28 days. The results of the present investigation indicate that silica fume incorporation results in significant improvements in the tensile strengths of concrete. It is also observed that the optimum replacement percentage, which led to maximization of strength, is not a constant one but depends on the water- cementitious material ratio of the mix. Compared to split tensile strengths, flexural strengths have exhibited greater percentage gains in strength. Increase in split tensile strength beyond 15% silica fume replacement is almost insignificant whereas sizeable gains in flexural tensile strength have occurred even up to 25% replacements. For the present investigation transgranular failure of concrete was observed which indicate that silica fume incorporation results in significant improvements in the strength of both paste and transition zone. (authors)

  18. Relativistic many-body calculation of energies, transition rates, lifetimes, and multipole polarizabilities in Cs-like La iii

    Science.gov (United States)

    Safronova, U. I.; Safronova, M. S.

    2014-05-01

    Excitation energies of the [Xe]nd (n =5-9), [Xe]ns (n =6-10), [Xe]np (n =6-9), [Xe]nf (n =4-8), and [Xe]ng (n =5-8) states in La iii, where [Xe] = 1s22s22p63s23p63d104s24p64d105s25p6, are evaluated. Electric dipole matrix elements for the allowed transitions between the low-lying [Xe]nd, [Xe]ns, [Xe]np, [Xe]nf, and [Xe]ng states in the La iii ion are calculated using the high-precision relativistic all-order method where all single, double, and partial triple excitations of the Dirac-Fock wave functions are included to all orders of perturbation theory. Recommended values are provided for a large number of electric dipole matrix elements, oscillator strengths, transition rates, and lifetimes. Scalar and tensor polarizabilities of the states listed above are evaluated. The uncertainties of the recommended values are estimated. Electric quadrupole and magnetic dipole matrix elements are calculated to determine lifetimes of the 5d5/2 and 6s metastable levels. The ground-state E1, E2, and E3 static polarizabilities are calculated. This work provides recommended values critically evaluated for their accuracy for a number of La iii atomic properties for use in planning and analysis of various experiments as well as theoretical modeling.

  19. Strength and life under creeping

    International Nuclear Information System (INIS)

    Pospishil, B.

    1982-01-01

    Certain examples of the application of the Lepin modified creep model, which are of interest from technical viewpoint, are presented. Mathematical solution of the dependence of strength limit at elevated temperatures on creep characteristics is obtained. Tensile test at elevated temperatures is a particular case of creep or relaxation and both strength limit and conventional yield strength at elevated temperatures are completely determined by parameters of state equations during creep. The equation of fracture summing during creep is confirmed not only by the experiment data when stresses change sporadically, but also by good reflection of durability curve using the system of equations. The system presented on the basis of parameters of the equations obtained on any part of durability curve, permits to forecast the following parameters of creep: strain, strain rate, life time, strain in the process of fracture. Tensile test at elevated temperature is advisable as an addition when determining creep curves (time-strain curves) [ru

  20. E1 and M1 strength functions at low energy

    Science.gov (United States)

    Schwengner, Ronald; Massarczyk, Ralph; Bemmerer, Daniel; Beyer, Roland; Junghans, Arnd R.; Kögler, Toni; Rusev, Gencho; Tonchev, Anton P.; Tornow, Werner; Wagner, Andreas

    2017-09-01

    We report photon-scattering experiments using bremsstrahlung at the γELBE facility of Helmholtz-Zentrum Dresden-Rossendorf and using quasi-monoenergetic, polarized γ beams at the HIγS facility of the Triangle Universities Nuclear Laboratory in Durham. To deduce the photoabsorption cross sections at high excitation energy and high level density, unresolved strength in the quasicontinuum of nuclear states has been taken into account. In the analysis of the spectra measured by using bremsstrahlung at γELBE, we perform simulations of statistical γ-ray cascades using the code γDEX to estimate intensities of inelastic transitions to low-lying excited states. Simulated average branching ratios are compared with model-independent branching ratios obtained from spectra measured by using monoenergetic γ beams at HIγS. E1 strength in the energy region of the pygmy dipole resonance is discussed in nuclei around mass 90 and in xenon isotopes. M1 strength in the region of the spin-flip resonance is also considered for xenon isotopes. The dipole strength function of 74Ge deduced from γELBE experiments is compared with the one obtained from experiments at the Oslo Cyclotron Laboratory. The low-energy upbend seen in the Oslo data is interpreted as M1 strength on the basis of shell-model calculations.

  1. E1 and M1 strength functions at low energy

    Directory of Open Access Journals (Sweden)

    Schwengner Ronald

    2017-01-01

    Full Text Available We report photon-scattering experiments using bremsstrahlung at the γELBE facility of Helmholtz-Zentrum Dresden-Rossendorf and using quasi-monoenergetic, polarized γ beams at the HIγS facility of the Triangle Universities Nuclear Laboratory in Durham. To deduce the photoabsorption cross sections at high excitation energy and high level density, unresolved strength in the quasicontinuum of nuclear states has been taken into account. In the analysis of the spectra measured by using bremsstrahlung at γELBE, we perform simulations of statistical γ-ray cascades using the code γDEX to estimate intensities of inelastic transitions to low-lying excited states. Simulated average branching ratios are compared with model-independent branching ratios obtained from spectra measured by using monoenergetic γ beams at HIγS. E1 strength in the energy region of the pygmy dipole resonance is discussed in nuclei around mass 90 and in xenon isotopes. M1 strength in the region of the spin-flip resonance is also considered for xenon isotopes. The dipole strength function of 74Ge deduced from γELBE experiments is compared with the one obtained from experiments at the Oslo Cyclotron Laboratory. The low-energy upbend seen in the Oslo data is interpreted as M1 strength on the basis of shell-model calculations.

  2. Withdrawal Strength and Bending Yield Strength of Stainless Steel Nails

    Science.gov (United States)

    Douglas R. Rammer; Samuel L. Zelinka

    2015-01-01

    It has been well established that stainless steel nails have superior corrosion performance compared to carbon steel or galvanized nails in treated wood; however, their mechanical fastening behavior is unknown. In this paper, the performance of stainless steel nails is examined with respect to two important properties used in wood connection design: withdrawal strength...

  3. New truncation mutation of the NR2E3 gene in a Japanese patient with enhanced S-cone syndrome.

    Science.gov (United States)

    Kuniyoshi, Kazuki; Hayashi, Takaaki; Sakuramoto, Hiroyuki; Mishima, Hiroshi; Tsuneoka, Hiroshi; Tsunoda, Kazushige; Iwata, Takeshi; Shimomura, Yoshikazu

    2016-11-01

    The enhanced S-cone syndrome (ESCS) is a rare hereditary retinal degeneration that has enhanced short wavelength-sensitive cone (S-cone) functions. The longitudinal clinical course of this disease has been rarely reported, and the genetic aspects of ESCS have not been well investigated in the Japanese population. In this report, we present our clinical and genetic findings for 2 patients with ESCS. The patients were 2 unrelated Japanese men. Standard ophthalmic examinations and mutation screening for the NR2E3 gene were performed. Patient 1 was a 36-year-old man, and his clinical findings were typical of ESCS. His decimal best-corrected visual acuity (BCVA) was 1.0 OD and 0.5 OS after removal of cataracts. Genetic investigations revealed a homozygous truncation frameshift, the p.I307LfsX33 mutation. Patient 2 was an 11-year-old boy when he was first examined by us. His clinical findings were typical of ESCS except for uveitis in the left eye. His decimal BCVA at the age of 39 years was maintained at 1.5 in each eye, although the retinal degeneration and visual field impairments had progressed during the follow-up period. The genetic investigations revealed homozygous mutations of p.R104Q in the NR2E3 gene. The frameshift mutation, p.I307LfsX33, in the NR2E3 gene is a new causative mutation for ESCS. The clinical observations for patient 2 are the longest ever reported. The retinal degeneration caused by this mutation is slowly progressive, and these patients maintained good vision with maintenance of the foveal structure until their late thirties.

  4. Strength Properties of Aalborg Clay

    DEFF Research Database (Denmark)

    Iversen, Kirsten Malte; Nielsen, Benjaminn Nordahl; Augustesen, Anders Hust

    glacial time are characterised by the absence of this mussel. These deposits are named Aalborg Clay and Aalborg Sand. In the city of Aalborg, a fill layer superposes Aalborg Clay. This layer is at some places found to be 6m thick. This fill layer does not provide sufficient bearing capacity, which has...... resulted in many damaged buildings in Aalborg. To provide sufficient bearing capacity it is therefore necessary either to remove the fill or to construct the building on piles. Both methods imply that the strength of Aalborg Clay is important for the construction. This paper evaluates the strength...

  5. Transitions between compound states of spherical nuclei

    International Nuclear Information System (INIS)

    Kadmenskii, S.G.; Markushev, V.P.; Furman, V.I.

    1980-01-01

    Wigner's statistical matrices are used to study the average reduced g widths and their dispersion for g transitions from a compound state c to another state f, with a lower excitation energy but of arbitrary complexity, for spherical nuclei. It is found that the Porter--Thomas distribution holds for the g widths for all cases of practical interest. In g transitions between compound states c and c' with E/sub g/< or =2 MeV, the most important transitions are M1 transitions involving the major many-quasiparticle components of state c and E1 transitions involving the minor components of state c. It is shown that the strength functions predicted by the various theories for M1 and E1 transitions between compound states with E/sub g/< or =2 MeV are similar. Preference is assigned to the M1-transition version because of experimental results on (n,ga) reactions with thermal and resonance neutrons

  6. γ transitions from 30P and 32S nuclei resonance levels

    International Nuclear Information System (INIS)

    Kostin, V.Ya.; Kopanets, E.G.; Koval', A.A.

    1977-01-01

    The probability distributions of dipole and quadrupole electromagnetic transitions from resonance excitation-energy range from 6.2 to 8.3 MeV and from 9.2 to 12.0 MeV respectively, were obtained. An analysis of the distributions shows that isovector dipole electic and magnetic transitions are comparable in magnitude with transitions between bound states. Isoscalar dipole transitions are stronger by an order of magnitude than transitions between bound states. This may be attributed to the increase in isospin mixing in the resonance range of excitation of atomic nuclei. Quadrupole electrical transitions have strengths comparable with those of transitions between bound states. For magnetic quadrupole transitions, a strong increase in transition probabilities compared with transitions between bound states is noted. The isospin selection rules for γ transitions in self-conjugate nuclei are discussed

  7. Single or multiple synchronization transitions in scale-free neuronal networks with electrical or chemical coupling

    International Nuclear Information System (INIS)

    Hao Yinghang; Gong, Yubing; Wang Li; Ma Xiaoguang; Yang Chuanlu

    2011-01-01

    Research highlights: → Single synchronization transition for gap-junctional coupling. → Multiple synchronization transitions for chemical synaptic coupling. → Gap junctions and chemical synapses have different impacts on synchronization transition. → Chemical synapses may play a dominant role in neurons' information processing. - Abstract: In this paper, we have studied time delay- and coupling strength-induced synchronization transitions in scale-free modified Hodgkin-Huxley (MHH) neuron networks with gap-junctions and chemical synaptic coupling. It is shown that the synchronization transitions are much different for these two coupling types. For gap-junctions, the neurons exhibit a single synchronization transition with time delay and coupling strength, while for chemical synapses, there are multiple synchronization transitions with time delay, and the synchronization transition with coupling strength is dependent on the time delay lengths. For short delays we observe a single synchronization transition, whereas for long delays the neurons exhibit multiple synchronization transitions as the coupling strength is varied. These results show that gap junctions and chemical synapses have different impacts on the pattern formation and synchronization transitions of the scale-free MHH neuronal networks, and chemical synapses, compared to gap junctions, may play a dominant and more active function in the firing activity of the networks. These findings would be helpful for further understanding the roles of gap junctions and chemical synapses in the firing dynamics of neuronal networks.

  8. Single or multiple synchronization transitions in scale-free neuronal networks with electrical or chemical coupling

    Energy Technology Data Exchange (ETDEWEB)

    Hao Yinghang [School of Physics, Ludong University, Yantai 264025 (China); Gong, Yubing, E-mail: gongyubing09@hotmail.co [School of Physics, Ludong University, Yantai 264025 (China); Wang Li; Ma Xiaoguang; Yang Chuanlu [School of Physics, Ludong University, Yantai 264025 (China)

    2011-04-15

    Research highlights: Single synchronization transition for gap-junctional coupling. Multiple synchronization transitions for chemical synaptic coupling. Gap junctions and chemical synapses have different impacts on synchronization transition. Chemical synapses may play a dominant role in neurons' information processing. - Abstract: In this paper, we have studied time delay- and coupling strength-induced synchronization transitions in scale-free modified Hodgkin-Huxley (MHH) neuron networks with gap-junctions and chemical synaptic coupling. It is shown that the synchronization transitions are much different for these two coupling types. For gap-junctions, the neurons exhibit a single synchronization transition with time delay and coupling strength, while for chemical synapses, there are multiple synchronization transitions with time delay, and the synchronization transition with coupling strength is dependent on the time delay lengths. For short delays we observe a single synchronization transition, whereas for long delays the neurons exhibit multiple synchronization transitions as the coupling strength is varied. These results show that gap junctions and chemical synapses have different impacts on the pattern formation and synchronization transitions of the scale-free MHH neuronal networks, and chemical synapses, compared to gap junctions, may play a dominant and more active function in the firing activity of the networks. These findings would be helpful for further understanding the roles of gap junctions and chemical synapses in the firing dynamics of neuronal networks.

  9. Strengths, Weaknesses, Opportunities and Threats

    NARCIS (Netherlands)

    Bull, J.W.; Jobstvogt, N.; Böhnke-Henrichs, A.; Mascarenhas, A.; Sitas, N.; Baulcomb, C.; Lambini, C.K.; Rawlins, M.; Baral, H.; Zähringer, J.; Carter-Silk, E.; Balzan, M.V.; Kenter, J.O.; Häyhä, T.; Petz, K.; Koss, R.

    2016-01-01

    The ecosystem services concept (ES) is becoming a cornerstone of contemporary sustainability thought. Challenges with this concept and its applications are well documented, but have not yet been systematically assessed alongside strengths and external factors that influence uptake. Such an

  10. On strength of porous material

    DEFF Research Database (Denmark)

    Nielsen, Lauge Fuglsang

    1999-01-01

    The question of non-destructive testing of porous materials has always been of interest for the engineering profession. A number of empirically based MOE-MOR relations between stiffness (Modulus Of Elasticity) and strength (Modulus OF Rupture) of materials have been established in order to control...

  11. Strengths, weaknesses, opportunities and threats

    DEFF Research Database (Denmark)

    Bull, Joseph William; Jobstvogt, N.; Böhnke-Henrichs, A.

    2016-01-01

    The ecosystem services concept (ES) is becoming a cornerstone of contemporary sustainability thought. Challenges with this concept and its applications are well documented, but have not yet been systematically assessed alongside strengths and external factors that influence uptake. Such an assess...

  12. Comparing strengths of beliefs explicitly

    NARCIS (Netherlands)

    Ghosh, S.; de Jongh, D.

    2013-01-01

    Inspired by a similar use in provability logic, formulas p > B q and p ≥ B q are introduced in the existing logical framework for discussing beliefs to express that the strength of belief in p is greater than (or equal to) that in q. Besides its usefulness in studying the properties of the concept

  13. Strength training for the warfighter.

    Science.gov (United States)

    Kraemer, William J; Szivak, Tunde K

    2012-07-01

    Optimizing strength training for the warfighter is challenged by past training philosophies that no longer serve the modern warfighter facing the "anaerobic battlefield." Training approaches for integration of strength with other needed physical capabilities have been shown to require a periodization model that has the flexibility for changes and is able to adapt to ever-changing circumstances affecting the quality of workouts. Additionally, sequencing of workouts to limit over-reaching and development of overtraining syndromes that end in loss of duty time and injury are paramount to long-term success. Allowing adequate time for rest and recovery and recognizing the negative influences of extreme exercise programs and excessive endurance training will be vital in moving physical training programs into a more modern perspective as used by elite strength-power anaerobic athletes in sports today. Because the warfighter is an elite athlete, it is time that training approaches that are scientifically based are updated within the military to match the functional demands of modern warfare and are given greater credence and value at the command levels. A needs analysis, development of periodized training modules, and individualization of programs are needed to optimize the strength of the modern warfighter. We now have the knowledge, professional coaches and nonprofit organization certifications with continuing education units, and modern training technology to allow this to happen. Ultimately, it only takes command decisions and implementation to make this possible.

  14. Modeling of Sylgard Adhesive Strength

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, Ralph Robert [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-03

    Sylgard is the name of a silicone elastomeric potting material manufactured by Dow Corning Corporation.1 Although the manufacturer cites its low adhesive strength as a feature of this product, thin layers of Sylgard do in fact have a non-negligible strength, which has been measured in recent tensile and shear debonding tests. The adhesive strength of thin layers of Sylgard potting material can be important in applications in which components having signi cantly di erent thermal expansion properties are potted together, and the potted assembly is subjected to temperature changes. The tensile and shear tractions developed on the potted surfaces of the components can cause signi cant internal stresses, particularly for components made of low-strength materials with a high area-to-volume ratio. This report is organized as follows: recent Sylgard debonding tests are rst brie y summarized, with particular attention to the adhesion between Sylgard and PBX 9501, and also between Sylgard and aluminum. Next, the type of numerical model that will be used to simulate the debonding behavior exhibited in these tests is described. Then the calibration of the debonding model will be illustrated. Finally, the method by which the model parameters are adjusted (scaled) to be applicable to other, non- tested bond thicknesses is summarized, and all parameters of the model (scaled and unscaled) are presented so that other investigators can reproduce all of the simulations described in this report as well as simulations of the application of interest.

  15. COP1 Controls Abiotic Stress Responses by Modulating AtSIZ1 Function Through its E3 Ubiquitin Ligase Activity

    Directory of Open Access Journals (Sweden)

    Joo Yong Kim

    2016-08-01

    Full Text Available Ubiquitination and sumoylation are essential post-translational modifications that regulate growth and development processes in plants, including control of hormone signaling mechanisms and responses to stress. This study showed that COP1 (Constitutive photomorphogenic 1 regulated the activity of Arabidopsis E3 SUMO (Small ubiquitin-related modifier ligase AtSIZ1 through its E3 ubiquitin ligase activity. Yeast two hybrid analysis demonstrated that COP1 and AtSIZ1 directly interacted with one another, and subcellular localization assays indicated that COP1 and AtSIZ1 co-localized in nuclear bodies. Analysis of ubiquitination showed that AtSIZ1 was polyubiquitinated by COP1. The AtSIZ1 level was higher in cop1-4 mutants than in wild-type seedlings under light or dark conditions, and overexpression of a dominant-negative (DN-COP1 mutant led to a substantial increase in AtSIZ1 accumulation. In addition, under drought, cold, and high salt conditions, SUMO-conjugate levels were elevated in DN-COP1-overexpressing plants and cop1-4 mutant plants compared to wild-type plants. Taken together, our results indicate that COP1 controls responses to abiotic stress by modulation of AtSIZ1 levels and activity.

  16. The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members.

    Directory of Open Access Journals (Sweden)

    Jana Kamanova

    2016-04-01

    Full Text Available Salmonella Typhimurium stimulates inflammatory responses in the intestinal epithelium, which are essential for its ability to replicate within the intestinal tract. Stimulation of these responses is strictly dependent on the activity of a type III secretion system encoded within its pathogenicity island 1, which through the delivery of effector proteins, triggers signaling pathways leading to inflammation. One of these effectors is SopA, a HECT-type E3 ligase, which is required for the efficient stimulation of inflammation in an animal model of Salmonella Typhimurium infection. We show here that SopA contributes to the stimulation of innate immune responses by targeting two host E3 ubiquitin ligases, TRIM56 and TRIM65. We also found that TRIM65 interacts with the innate immune receptor MDA5 enhancing its ability to stimulate interferon-β signaling. Therefore, by targeting TRIM56 and TRIM65, SopA can stimulate signaling through two innate immune receptors, RIG-I and MDA5. These findings describe a Salmonella mechanism to modulate inflammatory responses by directly targeting innate immune signaling mechanisms.

  17. Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.

    Directory of Open Access Journals (Sweden)

    Xi-Juan Liu

    2017-07-01

    Full Text Available Congenital human cytomegalovirus (HCMV infection is the leading cause of neurological disabilities in children worldwide, but the mechanisms underlying these disorders are far from well-defined. HCMV infection has been shown to dysregulate the Notch signaling pathway in human neural progenitor cells (NPCs. As an important downstream effector of Notch signaling, the transcriptional regulator Hairy and Enhancer of Split 1 (Hes1 is essential for governing NPC fate and fetal brain development. In the present study, we report that HCMV infection downregulates Hes1 protein levels in infected NPCs. The HCMV 72-kDa immediate-early 1 protein (IE1 is involved in Hes1 degradation by assembling a ubiquitination complex and promoting Hes1 ubiquitination as a potential E3 ubiquitin ligase, followed by proteasomal degradation of Hes1. Sp100A, an important component of PML nuclear bodies, is identified to be another target of IE1-mediated ubiquitination. A C-terminal acidic region in IE1, spanning amino acids 451 to 475, is required for IE1/Hes1 physical interaction and IE1-mediated Hes1 ubiquitination, but is dispensable for IE1/Sp100A interaction and ubiquitination. Our study suggests a novel mechanism linking downregulation of Hes1 protein to neurodevelopmental disorders caused by HCMV infection. Our findings also complement the current knowledge of herpesviruses by identifying IE1 as the first potential HCMV-encoded E3 ubiquitin ligase.

  18. The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.

    Directory of Open Access Journals (Sweden)

    Raymond Buser

    2016-02-01

    Full Text Available Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4, but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and the putative substrate adaptor Mms22 promotes progression of replication forks through damaged DNA. Here we characterized the interactome of Mms22 and found that the Rtt101(Mms22 ligase associates with the replisome progression complex during S-phase via the amino-terminal WD40 domain of Ctf4. Moreover, genetic screening for suppressors of the genotoxic sensitivity of rtt101Δ cells identified a cluster of replication proteins, among them a component of the fork protection complex, Mrc1. In contrast to rtt101Δ and mms22Δ cells, mrc1Δ rtt101Δ and mrc1Δ mms22Δ double mutants complete DNA replication upon replication stress by facilitating the repair/restart of stalled replication forks using a Rad52-dependent mechanism. Our results suggest that the Rtt101(Mms22 E3 ligase does not induce Mrc1 degradation, but specifically counteracts Mrc1's replicative function, possibly by modulating its interaction with the CMG (Cdc45-MCM-GINS complex at stalled forks.

  19. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

    Science.gov (United States)

    Paolino, Magdalena; Choidas, Axel; Wallner, Stephanie; Pranjic, Blanka; Uribesalgo, Iris; Loeser, Stefanie; Jamieson, Amanda M; Langdon, Wallace Y; Ikeda, Fumiyo; Fededa, Juan Pablo; Cronin, Shane J; Nitsch, Roberto; Schultz-Fademrecht, Carsten; Eickhoff, Jan; Menninger, Sascha; Unger, Anke; Torka, Robert; Gruber, Thomas; Hinterleitner, Reinhard; Baier, Gottfried; Wolf, Dominik; Ullrich, Axel; Klebl, Bert M; Penninger, Josef M

    2014-03-27

    Tumour metastasis is the primary cause of mortality in cancer patients and remains the key challenge for cancer therapy. New therapeutic approaches to block inhibitory pathways of the immune system have renewed hopes for the utility of such therapies. Here we show that genetic deletion of the E3 ubiquitin ligase Cbl-b (casitas B-lineage lymphoma-b) or targeted inactivation of its E3 ligase activity licenses natural killer (NK) cells to spontaneously reject metastatic tumours. The TAM tyrosine kinase receptors Tyro3, Axl and Mer (also known as Mertk) were identified as ubiquitylation substrates for Cbl-b. Treatment of wild-type NK cells with a newly developed small molecule TAM kinase inhibitor conferred therapeutic potential, efficiently enhancing anti-metastatic NK cell activity in vivo. Oral or intraperitoneal administration using this TAM inhibitor markedly reduced murine mammary cancer and melanoma metastases dependent on NK cells. We further report that the anticoagulant warfarin exerts anti-metastatic activity in mice via Cbl-b/TAM receptors in NK cells, providing a molecular explanation for a 50-year-old puzzle in cancer biology. This novel TAM/Cbl-b inhibitory pathway shows that it might be possible to develop a 'pill' that awakens the innate immune system to kill cancer metastases.

  20. Pathways to a low-carbon economy for the UK with the macro-econometric E3MG model

    International Nuclear Information System (INIS)

    Dagoumas, A.S.; Barker, T.S.

    2010-01-01

    This paper examines different carbon pathways for achieving deep CO 2 reduction targets for the UK using a macro-econometric hybrid model E3MG, which stands for Energy-Economy-Environment Model at the Global level. The E3MG, with the UK as one of its regions, combines a top-down approach for modeling the global economy and for estimating the aggregate and disaggregate energy demand and a bottom-up approach (Energy Technology subModel, ETM) for simulating the power sector, which then provides feedback to the energy demand equations and the whole economy. The ETM submodel uses a probabilistic approach and historical data for estimating the penetration levels of the different technologies, considering their economic, technical and environmental characteristics. Three pathway scenarios (CFH, CLC and CAM) simulate the CO 2 reduction by 40%, 60% and 80% by 2050 compared to 1990 levels respectively and are compared with a reference scenario (REF), with no reduction target. The targets are modeled as the UK contribution to an international mitigation effort, such as achieving the G8 reduction targets, which is a more realistic political framework for the UK to move towards deep reductions rather than moving alone. This paper aims to provide modeling evidence that deep reduction targets can be met through different carbon pathways while also assessing the macroeconomic effects of the pathways on GDP and investment.

  1. The putative E3 ubiquitin ligase ECERIFERUM9 regulates abscisic acid biosynthesis and response during seed germination and postgermination growth in arabidopsis

    KAUST Repository

    Zhao, Huayan

    2014-05-08

    The ECERIFERUM9 (CER9) gene encodes a putative E3 ubiquitin ligase that functions in cuticle biosynthesis and the maintenance of plant water status. Here, we found that CER9 is also involved in abscisic acid (ABA) signaling in seeds and young seedlings of Arabidopsis (Arabidopsis thaliana). The germinated embryos of the mutants exhibited enhanced sensitivity to ABA during the transition from reversible dormancy to determinate seedling growth. Expression of the CER9 gene is closely related to ABA levels and displays a similar pattern to that of ABSCISIC ACID-INSENSITIVE5 (ABI5), which encodes a positive regulator of ABA responses in seeds. cer9 mutant seeds exhibited delayed germination that is independent of seed coat permeability. Quantitative proteomic analyses showed that cer9 seeds had a protein profile similar to that of the wild type treated with ABA. Transcriptomics analyses revealed that genes involved in ABA biosynthesis or signaling pathways were differentially regulated in cer9 seeds. Consistent with this, high levels of ABA were detected in dry seeds of cer9. Blocking ABA biosynthesis by fluridone treatment or by combining an ABA-deficient mutation with cer9 attenuated the phenotypes of cer9. Whereas introduction of the abi1-1, abi3-1, or abi4-103 mutation could completely eliminate the ABA hypersensitivity of cer9, introduction of abi5 resulted only in partial suppression. These results indicate that CER9 is a novel negative regulator of ABA biosynthesis and the ABA signaling pathway during seed germination. © 2014 American Society of Plant Biologists. All Rights Reserved.

  2. The Putative E3 Ubiquitin Ligase ECERIFERUM9 Regulates Abscisic Acid Biosynthesis and Response during Seed Germination and Postgermination Growth in Arabidopsis.

    Science.gov (United States)

    Zhao, Huayan; Zhang, Huoming; Cui, Peng; Ding, Feng; Wang, Guangchao; Li, Rongjun; Jenks, Matthew A; Lü, Shiyou; Xiong, Liming

    2014-07-01

    The ECERIFERUM9 (CER9) gene encodes a putative E3 ubiquitin ligase that functions in cuticle biosynthesis and the maintenance of plant water status. Here, we found that CER9 is also involved in abscisic acid (ABA) signaling in seeds and young seedlings of Arabidopsis (Arabidopsis thaliana). The germinated embryos of the mutants exhibited enhanced sensitivity to ABA during the transition from reversible dormancy to determinate seedling growth. Expression of the CER9 gene is closely related to ABA levels and displays a similar pattern to that of ABSCISIC ACID-INSENSITIVE5 (ABI5), which encodes a positive regulator of ABA responses in seeds. cer9 mutant seeds exhibited delayed germination that is independent of seed coat permeability. Quantitative proteomic analyses showed that cer9 seeds had a protein profile similar to that of the wild type treated with ABA. Transcriptomics analyses revealed that genes involved in ABA biosynthesis or signaling pathways were differentially regulated in cer9 seeds. Consistent with this, high levels of ABA were detected in dry seeds of cer9. Blocking ABA biosynthesis by fluridone treatment or by combining an ABA-deficient mutation with cer9 attenuated the phenotypes of cer9. Whereas introduction of the abi1-1, abi3-1, or abi4-103 mutation could completely eliminate the ABA hypersensitivity of cer9, introduction of abi5 resulted only in partial suppression. These results indicate that CER9 is a novel negative regulator of ABA biosynthesis and the ABA signaling pathway during seed germination. © 2014 American Society of Plant Biologists. All Rights Reserved.

  3. The Putative E3 Ubiquitin Ligase ECERIFERUM9 Regulates Abscisic Acid Biosynthesis and Response during Seed Germination and Postgermination Growth in Arabidopsis1[W][OPEN

    Science.gov (United States)

    Zhao, Huayan; Zhang, Huoming; Cui, Peng; Ding, Feng; Wang, Guangchao; Li, Rongjun; Jenks, Matthew A.; Lü, Shiyou; Xiong, Liming

    2014-01-01

    The ECERIFERUM9 (CER9) gene encodes a putative E3 ubiquitin ligase that functions in cuticle biosynthesis and the maintenance of plant water status. Here, we found that CER9 is also involved in abscisic acid (ABA) signaling in seeds and young seedlings of Arabidopsis (Arabidopsis thaliana). The germinated embryos of the mutants exhibited enhanced sensitivity to ABA during the transition from reversible dormancy to determinate seedling growth. Expression of the CER9 gene is closely related to ABA levels and displays a similar pattern to that of ABSCISIC ACID-INSENSITIVE5 (ABI5), which encodes a positive regulator of ABA responses in seeds. cer9 mutant seeds exhibited delayed germination that is independent of seed coat permeability. Quantitative proteomic analyses showed that cer9 seeds had a protein profile similar to that of the wild type treated with ABA. Transcriptomics analyses revealed that genes involved in ABA biosynthesis or signaling pathways were differentially regulated in cer9 seeds. Consistent with this, high levels of ABA were detected in dry seeds of cer9. Blocking ABA biosynthesis by fluridone treatment or by combining an ABA-deficient mutation with cer9 attenuated the phenotypes of cer9. Whereas introduction of the abi1-1, abi3-1, or abi4-103 mutation could completely eliminate the ABA hypersensitivity of cer9, introduction of abi5 resulted only in partial suppression. These results indicate that CER9 is a novel negative regulator of ABA biosynthesis and the ABA signaling pathway during seed germination. PMID:24812105

  4. Gamow-teller transitions: progress and problems

    International Nuclear Information System (INIS)

    Walter, G.

    1994-01-01

    The determination of the Gamow-Teller (GT) matrix elements from beta-decay and charge exchange reactions has led to a series of discoveries concerning the structure of the nucleus and the properties of spin-isospin transitions in nuclei. The study of GT distribution and strength, either by charge exchange or weak decay, provides excellent tests for nuclear models as these parameters are extremely sensitive to the details of nuclear structure. Recent improvements of these models have reduced, for the most part, differences between experiment and theory, allowing in turn a more reliable estimate of weak decay rates in stellar matter. A better understanding of the 'missing strength' and of the failure of many experiments to detect the strength that is present have also been obtained. Recently, it appears also that weak decay studies in selected region (proton or neutron rich) of the N-Z plane give access to the GT giant resonance. (J.S.). 65 refs., 10 figs

  5. Impact strength of the uranium-6 weight percent niobium alloy between -1980 and +2000C

    International Nuclear Information System (INIS)

    Anderson, R.C.

    1981-09-01

    A study was conducted to determine if a ductile-to-brittle transition wxisted for the uranium-6 wt % niobium (U-6Nb) alloy. Standard V-notched Charpy bars were made from both solution-quenched and solution-quenched and aged U-6Nb alloy and were tested between -198 0 and +200 0 C. It was found that a sharp ductile-brittle transition does not exist for the alloy. A linear relationship existed between test temperature and impact strength, and the alloy retained a significant amount of impact strength even at very low temperatures. 9 figures

  6. Intermediate coupling collision strengths from LS coupled R-matrix elements

    International Nuclear Information System (INIS)

    Clark, R.E.H.

    1978-01-01

    Fine structure collision strength for transitions between two groups of states in intermediate coupling and with inclusion of configuration mixing are obtained from LS coupled reactance matrix elements (R-matrix elements) and a set of mixing coefficients. The LS coupled R-matrix elements are transformed to pair coupling using Wigner 6-j coefficients. From these pair coupled R-matrix elements together with a set of mixing coefficients, R-matrix elements are obtained which include the intermediate coupling and configuration mixing effects. Finally, from the latter R-matrix elements, collision strengths for fine structure transitions are computed (with inclusion of both intermediate coupling and configuration mixing). (Auth.)

  7. Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2 (Arg158 -->Cys), E3-Leiden, and E2 (Lys146-->Gln), and effects of treatment with simvastatin

    NARCIS (Netherlands)

    Zhao, S.P.; Smelt, A.H.; Maagdenberg, A.M. van den; Tol, A. van; Vroom T.F.; Gevers Leuven, J.A.; Frants, R.R.; Havekes, L.M.; Laarse, A. van der; Hooft, F.M. van 't

    1994-01-01

    Using a density-gradient ultracentrifugation technique, we analyzed in detail the plasma lipoprotein profiles of 18 patients with familial dysbetalipoproteinemia (FD) who had apolipoprotein (apo) E2(Arg158-->Cys) homozygosity (the E2-158 variant, n = 6), apoE3-Leiden heterozygosity (the E3-Leiden

  8. Distinct functional domains contribute to degradation of the low density lipoprotein receptor (LDLR) by the E3 ubiquitin ligase inducible Degrader of the LDLR (IDOL)

    NARCIS (Netherlands)

    Sorrentino, Vincenzo; Scheer, Lilith; Santos, Ana; Reits, Eric; Bleijlevens, Boris; Zelcer, Noam

    2011-01-01

    We recently identified the liver X receptor-regulated E3 ubiquitin ligase inducible degrader of the LDL receptor (IDOL) as a modulator of lipoprotein metabolism. Acting as an E3 ubiquitin ligase, IDOL triggers ubiquitination and subsequent degradation of the low density lipoprotein receptor (LDLR).

  9. Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor

    NARCIS (Netherlands)

    Dijk, K.W. van; Vlijmen, B.J.M. van; Zee, A. van der; Hof, B. van 't; Boom, H. van der; Kobayashi, K.; Chan, L.; Havekes, L.M.; Hofker, M.H.

    1998-01-01

    We have investigated the interaction of apolipoprotein E2(Arg158- Cys) (apoE2) and apolipoprotein E3Leiden (apoE3-Leiden) with the very low density lipoprotein (VLDL) receptor in vivo and in vitro to define the possible role of this receptor in lipoprotein metabolism and atherosclerosis. The in vivo

  10. Biodiesel Mass Transit Demonstration

    Science.gov (United States)

    2010-04-01

    The Biodiesel Mass Transit Demonstration report is intended for mass transit decision makers and fleet managers considering biodiesel use. This is the final report for the demonstration project implemented by the National Biodiesel Board under a gran...

  11. Public Transit Stations

    Data.gov (United States)

    Department of Homeland Security — fixed rail transit stations within the Continental United States, Alaska, Hawaii, the District of Columbia, and Puerto Rico. The modes of transit that are serviced...

  12. Muscle Strength and Poststroke Hemiplegia

    DEFF Research Database (Denmark)

    Kristensen, Otto H; Stenager, Egon; Dalgas, Ulrik

    2017-01-01

    undergone peer review; and (4) were available in English or Danish. DATA EXTRACTION: The psychometric properties of isokinetic dynamometry were reviewed with respect to reliability, validity, and responsiveness. Furthermore, comparisons of strength between paretic, nonparetic, and comparable healthy muscles...... isokinetic dynamometry. DATA SOURCES: A systematic literature search of 7 databases was performed. STUDY SELECTION: Included studies (1) enrolled participants with definite poststroke hemiplegia according to defined criteria; (2) assessed muscle strength or power by criterion isokinetic dynamometry; (3) had...... were reviewed. DATA SYNTHESIS: Twenty studies covering 316 PPSH were included. High intraclass correlation coefficient (ICC) inter- and intrasession reliability was reported for isokinetic dynamometry, which was independent of the tested muscle group, contraction mode, and contraction velocity...

  13. Line strengths in WN stars

    International Nuclear Information System (INIS)

    Leep, E.M.

    1982-01-01

    The author has analyzed high-dispersion spectra of over 100 WN stars in the Galaxy and the Large Magellenic Cloud (LMC). Most of the spectra were obtained through 4-m telescopes (Conti, Leep, and Perry 1981). The measured strengths of the WN classification lines N III lambdalambda4634-41, N IV lambda4057, N V lambda4604 (Smith 1968) for stars on WN subtypes 2.5-8 are shown. The assignments of WN subtypes are based on visual estimates of ratios of line strengths according to the scheme of Smith (1968), except that stars appearing to be earlier than WN3 are classified as WN2 or WN2.5 as explained by van der Hucht et al. (1981) and by Conti, Leep and Perry (1981). (Auth.)

  14. Sustainable energy development in Austria until 2020: Insights from applying the integrated model “e3.at”

    Science.gov (United States)

    Stocker, Andrea; Großmann, Anett; Madlener, Reinhard; Wolter, Marc Ingo

    2011-01-01

    This paper reports on the Austrian research project “Renewable energy in Austria: Modeling possible development trends until 2020”. The project investigated possible economic and ecological effects of a substantially increased use of renewable energy sources in Austria. Together with stakeholders and experts, three different scenarios were defined, specifying possible development trends for renewable energy in Austria. The scenarios were simulated for the period 2006–2020, using the integrated environment–energy–economy model “e3.at”. The modeling results indicate that increasing the share of renewable energy sources in total energy use is an important but insufficient step towards achieving a sustainable energy system in Austria. A substantial increase in energy efficiency and a reduction of residential energy consumption also form important cornerstones of a sustainable energy policy. PMID:21976785

  15. The 3-D geological model around Chang'E-3 landing site based on lunar penetrating radar Channel 1 data

    Science.gov (United States)

    Yuan, Yuefeng; Zhu, Peimin; Zhao, Na; Xiao, Long; Garnero, Edward; Xiao, Zhiyong; Zhao, Jiannan; Qiao, Le

    2017-07-01

    High-frequency lunar penetrating radar (LPR) data from an instrument on the lunar rover Yutu, from the Chang'E-3 (CE-3) robotic lander, were used to build a three-dimensional (3-D) geological model of the lunar subsurface structure. The CE-3 landing site is in the northern Mare Imbrium. More than five significant reflection horizons are evident in the LPR profile, which we interpret as different period lava flow sequences deposited on the lunar surface. The most probable directions of these flows were inferred from layer depths, thicknesses, and other geological information. Moreover, the apparent Imbrian paleoregolith homogeneity in the profile supports the suggestion of a quiescent period of lunar surface evolution. Similar subsurface structures are found at the NASA Apollo landing sites, indicating that the cause and time of formation of the imaged phenomena may be similar between the two distant regions.

  16. H2B ubiquitination: Conserved molecular mechanism, diverse physiologic functions of the E3 ligase during meiosis.

    Science.gov (United States)

    Wang, Liying; Cao, Chunwei; Wang, Fang; Zhao, Jianguo; Li, Wei

    2017-09-03

    RNF20/Bre1 mediated H2B ubiquitination (H2Bub) has various physiologic functions. Recently, we found that H2Bub participates in meiotic recombination by promoting chromatin relaxation during meiosis. We then analyzed the phylogenetic relationships among the E3 ligase for H2Bub, its E2 Rad6 and their partner WW domain-containing adaptor with a coiled-coil (WAC) or Lge1, and found that the molecular mechanism underlying H2Bub is evolutionarily conserved from yeast to mammals. However, RNF20 has diverse physiologic functions in different organisms, which might be caused by the evolutionary divergency of their domain/motif architectures. In the current extra view, we not only elucidate the evolutionarily conserved molecular mechanism underlying H2Bub, but also discuss the diverse physiologic functions of RNF20 during meiosis.

  17. Structure of the Siz/PIAS SUMO E3 Ligase Siz1 and Determinants Required for SUMO Modification of PCNA

    Energy Technology Data Exchange (ETDEWEB)

    Yunus, Ali A.; Lima, Christopher D.; (SKI)

    2010-01-12

    Siz1 is a founding member of the Siz/PIAS RING family of SUMO E3 ligases. The X-ray structure of an active Siz1 ligase revealed an elongated tripartite architecture comprised of an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain we term the SP-CTD. Structure-based mutational analysis and biochemical studies show that the SP-RING and SP-CTD are required for activation of the E2SUMO thioester, while the PINIT domain is essential for redirecting SUMO conjugation to the proliferating cell nuclear antigen (PCNA) at lysine 164, a nonconsensus lysine residue that is not modified by the SUMO E2 in the absence of Siz1. Mutational analysis of Siz1 and PCNA revealed surfaces on both proteins that are required for efficient SUMO modification of PCNA in vitro and in vivo.

  18. Dissipation-driven quantum phase transitions in collective spin systems

    International Nuclear Information System (INIS)

    Morrison, S; Parkins, A S

    2008-01-01

    We consider two different collective spin systems subjected to strong dissipation-on the same scale as interaction strengths and external fields-and show that either continuous or discontinuous dissipative quantum phase transitions can occur as the dissipation strength is varied. First, we consider a well-known model of cooperative resonance fluorescence that can exhibit a second-order quantum phase transition, and analyse the entanglement properties near the critical point. Next, we examine a dissipative version of the Lipkin-Meshkov-Glick interacting collective spin model, where we find that either first- or second-order quantum phase transitions can occur, depending only on the ratio of the interaction and external field parameters. We give detailed results and interpretation for the steady-state entanglement in the vicinity of the critical point, where it reaches a maximum. For the first-order transition we find that the semiclassical steady states exhibit a region of bistability. (fast track communication)

  19. Soil strength and forest operations

    OpenAIRE

    Beekman, F.

    1987-01-01

    The use of heavy machinery and transport vehicles is an integral part of modern forest operations. This use often causes damage to the standing trees and to the soil. In this study the effects of vehicle traffic on the soil are analysed and the possible consequences for forest management discussed. The study is largely restricted to sandy and loamy soils because of their importance for Dutch forestry.

    Soil strength, defined as the resistance of soil structure against the impa...

  20. Electronic Correlation Strength of Pu

    DEFF Research Database (Denmark)

    Svane, A.; C. Albers, R.; E. Christensen, N.

    2013-01-01

    A new electronic quantity, the correlation strength, is defined as a necessary step for understanding the properties and trends in strongly correlated electronic materials. As a test case, this is applied to the different phases of elemental Pu. Within the GW approximation we have surprisingly...... found a "universal" scaling relationship, where the f-electron bandwidth reduction due to correlation effects is shown to depend only upon the local density approximation (LDA) bandwidth and is otherwise independent of crystal structure and lattice constant....

  1. Strength and Microstructure of Ceramics

    Science.gov (United States)

    1989-11-01

    Forex - one particular alumina ceramic, I our own detailed crack ample, the relatively large values of r, and c* for the VI observations, and those of...particularly toughness indices, 1i71", indicating that there is sonic the c° , T parameters. However, the indentation mcth- kind of trade -o1Tbetwecn...macroscopic and microsnpic odology takes us closer to the strengths of specimens toughness levels, and that this trade -off is cont’olled by with natural

  2. Long range supergravity coupling strengths

    International Nuclear Information System (INIS)

    Kenyon, I.R.

    1991-01-01

    A limit of 2x10 -13 has recently been deduced for the fractional difference between the gravitational masses of the K 0 and anti K 0 mesons. This limit is applied here to put stringent limits on the strengths of the long range vector-scalar gravitational couplings envisaged in supergravity theories. A weaker limit is inferred from the general relativistic fit to the precession of the orbit of the pulsar PSR1913+16. (orig.)

  3. Cosmological phase transitions

    International Nuclear Information System (INIS)

    Kolb, E.W.

    1993-10-01

    If modern ideas about the role of spontaneous symmetry breaking in fundamental physics are correct, then the Universe should have undergone a series of phase transitions early in its history. The study of cosmological phase transitions has become an important aspect of early-Universe cosmology. In this lecture I review some very recent work on three aspects of phase transitions: the electroweak transition, texture, and axions

  4. The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells.

    Science.gov (United States)

    Jumpertz, Sandra; Hennes, Thomas; Asare, Yaw; Vervoorts, Jörg; Bernhagen, Jürgen; Schütz, Anke K

    2014-09-01

    COP9 signalosome subunit 5 (CSN5) plays a decisive role in cellular processes such as cell cycle regulation and apoptosis via promoting protein degradation, gene transcription, and nuclear export. CSN5 regulates cullin-RING-E3 ligase (CRL) activity through its deNEDDylase function. It is overexpressed in several tumor entities, but its role in colorectal cancer (CRC) is poorly understood. Wnt/β-catenin signaling is aberrant in most CRC cells, resulting in increased levels of oncogenic β-catenin and thus tumor progression. Under physiological conditions, β-catenin levels are tightly regulated by continuous proteasomal degradation. We recently showed that knockdown of CSN5 in model and CRC cells results in decreased (phospho)-β-catenin levels. Reduced β-catenin levels were associated with an attenuated proliferation rate of different CRC cell types after CSN5 knockdown. The canonical Wnt pathway involves degradation of β-catenin by a β-TrCP1-containing E3 ligase, but is mostly non-functional in CRC cells. We thus hypothesized that alternative β-catenin degradation mediated by SIAH-1 (seven in absentia homolog-1), is responsible for the effect of CSN5 on β-catenin signaling in CRC cells. We found that SIAH-1 plays an essential role in β-catenin degradation in HCT116 CRC cells and that CSN5 affects β-catenin target gene expression in these cells. Of note, CSN5 affected SIAH-1 mRNA and SIAH-1 protein levels. Moreover, β-catenin and SIAH-1 form protein complexes with CSN5 in HCT116 cells. Lastly, we demonstrate that CSN5 promotes SIAH-1 degradation in HCT116 and SW480 cells and that this is associated with its deNEDDylase activity. In conclusion, we have identified a CSN5/β-catenin/SIAH-1 interaction network that might control β-catenin degradation in CRC cells. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis

    Science.gov (United States)

    Zhang, Jinfang; Wan, Lixin; Dai, Xiangpeng; Sun, Yi; Wei, Wenyi

    2014-01-01

    The Anaphase Promoting Complex/Cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that primarily governs cell cycle progression. APC/C is composed of at least 14 core subunits and recruits its substrates for ubiquitination via one of the two adaptor proteins, Cdc20 or Cdh1, in M or M/early G1 phase, respectively. Furthermore, recent studies have shed light on crucial functions for APC/C in maintaining genomic integrity, neuronal differentiation, cellular metabolism and tumorigenesis. To gain better insight into the in vivo physiological functions of APC/C in regulating various cellular processes, particularly development and tumorigenesis, a number of mouse models of APC/C core subunits, coactivators or inhibitors have been established and characterized. However, due to their essential role in cell cycle regulation, most of the germline knockout mice targeting the APC/C pathway are embryonic lethal, indicating the need for generating conditional knockout mouse models to assess the role in tumorigenesis for each APC/C signaling component in specific tissues. In this review, we will first provide a brief introduction of the ubiquitin-proteasome system (UPS) and the biochemical activities and cellular functions of the APC/C E3 ligase. We will then focus primarily on characterizing genetic mouse models used to understand the physiological roles of each APC/C signaling component in embryogenesis, cell proliferation, development and carcinogenesis. Finally, we discuss future research directions to further elucidate the physiological contributions of APC/C components during tumorigenesis and validate their potentials as a novel class of anti-cancer targets. PMID:24569229

  6. Pressure induced phase transitions in ceramic compounds containing tetragonal zirconia

    Energy Technology Data Exchange (ETDEWEB)

    Sparks, R.G.; Pfeiffer, G.; Paesler, M.A.

    1988-12-01

    Stabilized tetragonal zirconia compounds exhibit a transformation toughening process in which stress applied to the material induces a crystallographic phase transition. The phase transition is accompanied by a volume expansion in the stressed region thereby dissipating stress and increasing the fracture strength of the material. The hydrostatic component of the stress required to induce the phase transition can be investigated by the use of a high pressure technique in combination with Micro-Raman spectroscopy. The intensity of Raman lines characteristic for the crystallographic phases can be used to calculate the amount of material that has undergone the transition as a function of pressure. It was found that pressures on the order of 2-5 kBar were sufficient to produce an almost complete transition from the original tetragonal to the less dense monoclinic phase; while a further increase in pressure caused a gradual reversal of the transition back to the original tetragonal structure.

  7. Transitions to Synchrony in Coupled Bursting Neurons

    Science.gov (United States)

    Dhamala, Mukeshwar; Jirsa, Viktor K.; Ding, Mingzhou

    2004-01-01

    Certain cells in the brain, for example, thalamic neurons during sleep, show spike-burst activity. We study such spike-burst neural activity and the transitions to a synchronized state using a model of coupled bursting neurons. In an electrically coupled network, we show that the increase of coupling strength increases incoherence first and then induces two different transitions to synchronized states, one associated with bursts and the other with spikes. These sequential transitions to synchronized states are determined by the zero crossings of the maximum transverse Lyapunov exponents. These results suggest that synchronization of spike-burst activity is a multi-time-scale phenomenon and burst synchrony is a precursor to spike synchrony.

  8. Transitions to synchrony in coupled bursting neurons

    International Nuclear Information System (INIS)

    Dhamala, Mukeshwar; Jirsa, Viktor K.; Ding Mingzhou

    2004-01-01

    Certain cells in the brain, for example, thalamic neurons during sleep, show spike-burst activity. We study such spike-burst neural activity and the transitions to a synchronized state using a model of coupled bursting neurons. In an electrically coupled network, we show that the increase of coupling strength increases incoherence first and then induces two different transitions to synchronized states, one associated with bursts and the other with spikes. These sequential transitions to synchronized states are determined by the zero crossings of the maximum transverse Lyapunov exponents. These results suggest that synchronization of spike-burst activity is a multi-time-scale phenomenon and burst synchrony is a precursor to spike synchrony

  9. Near-ideal strength in metal nanotubes revealed by atomistic simulations

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Mingfei; Xiao, Fei [Department of Materials Science, Fudan University, 220 Handan Road, Shanghai 200433 (China); Deng, Chuang, E-mail: dengc@ad.umanitoba.ca [Department of Mechanical and Manufacturing Engineering, The University of Manitoba, 15Gillson Street, Winnipeg, Manitoba R3T 5V6 (Canada)

    2013-12-02

    Here we report extraordinary mechanical properties revealed by atomistic simulations in metal nanotubes with hollow interior that have been long overlooked. Particularly, the yield strength in [1 1 1] Au nanotubes is found to be up to 60% higher than the corresponding solid Au nanowire, which approaches the theoretical ideal strength in Au. Furthermore, a remarkable transition from sharp to smooth yielding is observed in Au nanotubes with decreasing wall thickness. The ultrahigh tensile strength in [1 1 1] Au nanotube might originate from the repulsive image force exerted by the interior surface against dislocation nucleation from the outer surface.

  10. Atomic structure calculation of energy levels and oscillator strengths in Ti ion, 2

    International Nuclear Information System (INIS)

    Ishii, Keishi

    1983-10-01

    Energy levels and oscillator strengths are calculated for 3s-3p and 3p-3d transition arrays in Ti X, isoelectronic to Al I. The energy levels are obtained by the Slater-Condon theory of atomic structure, including explicitly the strong configuration interactions. The results are presented both in numerical tables and in diagrams. In the tables, the observed data are included for comparison, where available. The calculated weighted oscillator strengths (gf-value) are also displayed in figures, where the weighted oscillator strengths are plotted as a function of wavelength. (author)

  11. Modeling for transition management

    NARCIS (Netherlands)

    Chappin, E.J.L.; Dijkema, G.P.J.

    2015-01-01

    A framework for the modeling and simulation of transitions is presented. A transition, “substantial change in the state of a socio-technical system”, typically unfolds over a long timespan. We therefore suggest to use simulation to inform transition managers on the effect of their decisions.

  12. Modeling for Transition Management

    NARCIS (Netherlands)

    Chappin, Emile J L; Dijkema, Gerard P.J.

    2015-01-01

    A framework for the modeling and simulation of transitions is presented. A transition, “substantial change in the state of a socio-technical system”, typically unfolds over a long timespan. We therefore suggest to use simulation to inform transition managers on the effect of their decisions.

  13. Microwave stability at transition

    International Nuclear Information System (INIS)

    Holt, J.A.; Colestock, P.L.

    1995-05-01

    The question of microwave stability at transition is revisited using a Vlasov approach retaining higher order terms in the particle dynamics near the transition energy. A dispersion relation is derived which can be solved numerically for the complex frequency in terms of the longitudinal impedance and other beam parameters. Stability near transition is examined and compared with simulation results

  14. Transit manager's handbook.

    Science.gov (United States)

    2011-09-01

    This handbook provides an overview of public transit in Iowa and how to do business with the Iowa Department of Transportation (Iowa DOT) Office of Public Transit (OPT). It is intended to be a tool to assist transit managers navigate through the many...

  15. Transit labor relations guide

    Science.gov (United States)

    2001-09-01

    This report is designed as a guide for those involved in labor relations in the transit industry. It begins with a history of transit labor relations. The economic, political, and legal environment of transit relations is then discussed. A section fo...

  16. Transition: Preschool to Kindergarten

    Science.gov (United States)

    Arizona Department of Education, 2007

    2007-01-01

    Transition is movement or change without interruption. It should be a smooth flow from one place or condition to another. While the transition plan for a student receiving special education services is designed to prepare him or her for life after high school, transition can start when a child enters preschool. The second of six distinct stages of…

  17. Micromechanical analysis of polyacrylamide-modified concrete for improving strengths

    Energy Technology Data Exchange (ETDEWEB)

    Sun Zengzhi [School of Materials Science and Engineering, Chang' an University, Xi' an 710064 (China)], E-mail: zz-sun@126.com; Xu Qinwu [Pavement research, Transtec Group Inc., Austin 78731 (United States)], E-mail: qinwu_xu@yahoo.com

    2008-08-25

    This paper studies how polyacrylamide (PAM) alters the physicochemical and mechanical properties of concrete. The microstructure of PAM-modified concrete and the physicochemical reaction between PAM and concrete were studied through scanning electron microscope (SEM), differential thermal analysis (DTA), thermal gravimetric analysis (TGA), and infrared spectrum analysis. Meanwhile, the workability and strengths of cement paste and concrete were tested. PAM's modification mechanism was also discussed. Results indicate that PAM reacts with the Ca{sup 2+} and Al{sup 3+} cations produced by concrete hydration to form the ionic compounds and reduce the crystallization of Ca(OH){sub 2}, acting as a flexible filler and reinforcement in the porosity of concrete and, therefore, improving concrete's engineering properties. PAM also significantly alters the microstructure at the aggregate-cement interfacial transition zone. Mechanical testing results indicate that the fluidity of cement paste decreases initially, then increases, and decreases again with increasing PAM content. PAM can effectively improve the flexural strength, bonding strength, dynamic impact resistance, and fatigue life of concrete, though it reduces the compressive strength to some extent.

  18. Micromechanical analysis of polyacrylamide-modified concrete for improving strengths

    International Nuclear Information System (INIS)

    Sun Zengzhi; Xu Qinwu

    2008-01-01

    This paper studies how polyacrylamide (PAM) alters the physicochemical and mechanical properties of concrete. The microstructure of PAM-modified concrete and the physicochemical reaction between PAM and concrete were studied through scanning electron microscope (SEM), differential thermal analysis (DTA), thermal gravimetric analysis (TGA), and infrared spectrum analysis. Meanwhile, the workability and strengths of cement paste and concrete were tested. PAM's modification mechanism was also discussed. Results indicate that PAM reacts with the Ca 2+ and Al 3+ cations produced by concrete hydration to form the ionic compounds and reduce the crystallization of Ca(OH) 2 , acting as a flexible filler and reinforcement in the porosity of concrete and, therefore, improving concrete's engineering properties. PAM also significantly alters the microstructure at the aggregate-cement interfacial transition zone. Mechanical testing results indicate that the fluidity of cement paste decreases initially, then increases, and decreases again with increasing PAM content. PAM can effectively improve the flexural strength, bonding strength, dynamic impact resistance, and fatigue life of concrete, though it reduces the compressive strength to some extent

  19. Exoplanet Transits of Stellar Active Regions

    Science.gov (United States)

    Giampapa, Mark S.; Andretta, Vincenzo; Covino, Elvira; Reiners, Ansgar; Esposito, Massimiliano

    2018-01-01

    We report preliminary results of a program to obtain high spectral- and temporal-resolution observations of the neutral helium triplet line at 1083.0 nm in transiting exoplanet systems. The principal objective of our program is to gain insight on the properties of active regions, analogous to solar plages, on late-type dwarfs by essentially using exoplanet transits as high spatial resolution probes of the stellar surface within the transit chord. The 1083 nm helium line is a particularly appropriate diagnostic of magnetized areas since it is weak in the quiet photosphere of solar-type stars but appears strongly in absorption in active regions. Therefore, during an exoplanet transit over the stellar surface, variations in its absorption equivalent width can arise that are functions of the intrinsic strength of the feature in the active region and the known relative size of the exoplanet. We utilized the Galileo Telescope and the GIANO-B near-IR echelle spectrograph to obtain 1083 nm spectra during transits in bright, well-known systems that include HD 189733, HD 209458, and HD 147506 (HAT-P-2). We also obtained simultaneous auxiliary data on the same telescope with the HARPS-N UV-Visible echelle spectrograph. We will present preliminary results from our analysis of the observed variability of the strength of the He I 1083 nm line during transits.Acknowledgements: Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias. The NSO is operated by AURA under a cooperative agreement with the NSF.

  20. Ideal glass transitions in thin films: An energy landscape perspective

    OpenAIRE

    Truskett, Thomas M.; Ganesan, Venkat

    2003-01-01

    We introduce a mean-field model for the potential energy landscape of a thin fluid film confined between parallel substrates. The model predicts how the number of accessible basins on the energy landscape and, consequently, the film's ideal glass transition temperature depend on bulk pressure, film thickness, and the strength of the fluid-fluid and fluid-substrate interactions. The predictions are in qualitative agreement with the experimental trends for the kinetic glass transition temperatu...

  1. Transition Theory – Sustainable Transition of Socio-Technical Systems

    DEFF Research Database (Denmark)

    Søndergård, Bent; Holm, Jesper; Stauning, Inger

    2015-01-01

    Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction......Theories of transition management, transition studies and social practise theory Applied to studies of hosuing and construction...

  2. A Variable Flow Modelling Approach To Military End Strength Planning

    Science.gov (United States)

    2016-12-01

    function. The MLRPS is more complex than the variable flow model as it has to cater for a force structure that is much larger than just the MT branch...essential positions in a Ship’s complement, or by the biggest current deficit in forecast end strength. The model can be adjusted to cater for any of these...is unlikely that the RAN will be able to cater for such an increase in hires, so this scenario is not likely to solve their problem. Each transition

  3. E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor

    International Nuclear Information System (INIS)

    Jenei, Veronika; Andersson, Tommy; Jakus, Judit; Dib, Karim

    2005-01-01

    E3B1, a human homologue of the mouse gene product Abi-1, has been implicated in growth-factor-mediated regulation of the small GTPases p21 Ras and Rac. E3b1 is a regulator of Rac because it can form a complex with Sos-1 and eps8, and such a Sos-1-e3B1-eps8 complex serves as a guanine nucleotide exchange factor for Rac. In the present study, we found that overexpression of e3B1 in NIH3T3/EGFR cells sensitized EGF-induced activation of Rac1, whereas it had no impact on EGF-induced activation of p21 Ras . Remarkably, we found that EGF-induced activation of the p21 Ras -related GTPase Rap1 was also sensitized in NIH3T3/EGFR-e3B1 cells. Thus, in NIH3T3/EGFR-e3B1 cells, maximal EGF-induced activation of Rap1 occurs with a dose of EGF much lower than in NIH3T3/EGFR cells. We also report that overexpression of e3B1 in NIH3T3/EGFR cells renders EGF-induced activation of Rap1 completely dependent on Src tyrosine kinases but not on c-Abl. However, EGF-induced tyrosine phosphorylation of the Rap GEF C3G occurred regardless of whether e3B1 was overexpressed or not, and this did not involve Src tyrosine kinases. Accordingly, we propose that overexpression of e3B1 in NIH3T3/EGFR cells leads to mobilization of Src tyrosine kinases that participate in EGF-induced activation of Rap1 and inhibition of cell proliferation

  4. Microbial community changes in methanogenic granules during the transition from mesophilic to thermophilic conditions

    DEFF Research Database (Denmark)

    Zhu, Xinyu; Kougias, Panagiotis; Treu, Laura

    2017-01-01

    Upflow anaerobic sludge blanket (UASB) reactor is one of the most applied technologies for various high-strength wastewater treatments. The present study analysed the microbial community changes in UASB granules during the transition from mesophilic to thermophilic conditions. Dynamicity...

  5. Phase transitions of quadrupolar fluids

    International Nuclear Information System (INIS)

    OShea, S.F.; Dubey, G.S.; Rasaiah, J.C.

    1997-01-01

    Gibbs ensemble simulations are reported for Lennard-Jones particles with embedded quadrupoles of strength Q * =Q/(εσ 5 ) 1/2 =2.0 where ε and σ are the Lennard-Jones parameters. Calculations revealing the effect of the dispersive forces on the liquid endash vapor coexistence were carried out by scaling the attractive r -6 term in the Lennard-Jones pair potential by a factor λ ranging from 0 to 1. Liquid endash vapor coexistence is observed for all values of λ including λ=0 for Q * =2.0, unlike the corresponding dipolar fluid studied by van Leeuwen and Smit et al. [Phys. Rev. Lett. 71, 3991 (1993)] which showed no phase transition below λ=0.35 when the reduced dipole moment μ * =2.0. The simulation data are analyzed to estimate the critical properties of the quadrupolar fluid and their dependence on the strength λ of the dispersive force. The critical temperature and pressure show a clear quadratic dependence on λ, while the density is less confidently identified as being linear in λ. The compressibility is roughly linear in λ. copyright 1997 American Institute of Physics

  6. Gifts from Exoplanetary Transits

    Science.gov (United States)

    Narita, Norio

    2009-08-01

    The discovery of transiting extrasolar planets has enabled us to do a number of interesting studies. Transit photometry reveals the radius and the orbital inclination of transiting planets, which allows us to learn the true mass and density of the respective planets by the combined information from radial velocity (RV) measurements. In addition, follow-up observations of transiting planets, looking at such things as secondary eclipses, transit timing variations, transmission spectroscopy, and the Rossiter-McLaughlin effect, provide us information about their dayside temperatures, unseen bodies in systems, planetary atmospheres, and the obliquity of planetary orbits. Such observational information, which will provide us a greater understanding of extrasolar planets, is available only for transiting planets. Here, I briefly summarize what we can learn from transiting planets and introduce previous studies.

  7. The relationship between compressive strength and flexural strength of pavement geopolymer grouting material

    Science.gov (United States)

    Zhang, L.; Han, X. X.; Ge, J.; Wang, C. H.

    2018-01-01

    To determine the relationship between compressive strength and flexural strength of pavement geopolymer grouting material, 20 groups of geopolymer grouting materials were prepared, the compressive strength and flexural strength were determined by mechanical properties test. On the basis of excluding the abnormal values through boxplot, the results show that, the compressive strength test results were normal, but there were two mild outliers in 7days flexural strength test. The compressive strength and flexural strength were linearly fitted by SPSS, six regression models were obtained by linear fitting of compressive strength and flexural strength. The linear relationship between compressive strength and flexural strength can be better expressed by the cubic curve model, and the correlation coefficient was 0.842.

  8. Isospin symmetry of T-z=+/- 3/2 ->+/- 1/2 Gamow-Teller transitions in A=41 nuclei

    NARCIS (Netherlands)

    Fujita, Y; Shimbara, Y; Adachi, T; Berg, GPA; Fujita, H; Hatanaka, K; Kamiya, J; Nakanishi, K; Sakemi, Y; Sasaki, S; Shimizu, Y; Tameshige, Y; Uchida, M; Wakasa, T; Yosoi, M

    2004-01-01

    Under the assumption that isospin T is a good quantum number, isobaric analog states and various analogous transitions are expected in isobars with mass number A. The, strengths of T-z = +/-3/2 --> 1/2 analogous Gamow-Teller (GT) transitions and analogous M1 transitions within the A = 41 isobar

  9. Isospin symmetry of T-z=+/- 3/2 ->+/- 1/2 Gamow-Teller transitions in A=41 nuclei

    NARCIS (Netherlands)

    Fujita, Y; Shimbara, Y; Adachi, T; Berg, GPA; Fujita, H; Hatanaka, K; Kamiya, J; Nakanishi, K; Sakemi, Y; Sasaki, S; Shimizu, Y; Tameshige, Y; Uchida, M; Wakasa, T; Yosoi, M

    Under the assumption that isospin T is a good quantum number, isobaric analog states and various analogous transitions are expected in isobars with mass number A. The, strengths of T-z = +/-3/2 --> 1/2 analogous Gamow-Teller (GT) transitions and analogous M1 transitions within the A = 41 isobar

  10. Flocking Transition in Confluent Tissues

    Science.gov (United States)

    Paoluzzi, Matteo; Giavazzi, Fabio; Macchi, Marta; Scita, Giorgio; Cerbino, Roberto; Manning, Lisa; Marchetti, Cristina

    The emerging of collective migration in biological tissues plays a pivotal role in embryonic morphogenesis, wound healing and cancer invasion. While many aspects of single cell movements are well established, the mechanisms leading to coherent displacements of cohesive cell groups are still poorly understood. Some of us recently proposed a Self-Propelled Voronoi (SPV) model of dense tissues that combines self-propelled particle models and vertex models of confluent cell layers and exhibits a liquid-solid transition as a function of cell shape and cell motility. We now examine the role of cell polarization on collective cell dynamics by introducing an orientation mechanism that aligns cell polarization with local cell motility. The model predicts a density-independent flocking transition tuned by the strength of the aligning interaction, with both solid and liquid flocking states existing in different regions of parameter space. MP and MCM were supported by the Simons Foundation Targeted Grant in the Mathematical Modeling of Living Systems Number: 342354 and by the Syracuse Soft Matter Program.

  11. Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.

    Science.gov (United States)

    Inturi, Raviteja; Mun, Kwangchol; Singethan, Katrin; Schreiner, Sabrina; Punga, Tanel

    2018-02-01

    Human adenoviruses (HAdVs) are common human pathogens encoding a highly abundant histone-like core protein, VII, which is involved in nuclear delivery and protection of viral DNA as well as in sequestering immune danger signals in infected cells. The molecular details of how protein VII acts as a multifunctional protein have remained to a large extent enigmatic. Here we report the identification of several cellular proteins interacting with the precursor pVII protein. We show that the cellular E3 ubiquitin ligase MKRN1 is a novel precursor pVII-interacting protein in HAdV-C5-infected cells. Surprisingly, the endogenous MKRN1 protein underwent proteasomal degradation during the late phase of HAdV-C5 infection in various human cell lines. MKRN1 protein degradation occurred independently of the HAdV E1B55K and E4orf6 proteins. We provide experimental evidence that the precursor pVII protein binding enhances MKRN1 self-ubiquitination, whereas the processed mature VII protein is deficient in this function. Based on these data, we propose that the pVII protein binding promotes MKRN1 self-ubiquitination, followed by proteasomal degradation of the MKRN1 protein, in HAdV-C5-infected cells. In addition, we show that measles virus and vesicular stomatitis virus infections reduce the MKRN1 protein accumulation in the recipient cells. Taken together, our results expand the functional repertoire of the HAdV-C5 precursor pVII protein in lytic virus infection and highlight MKRN1 as a potential common target during different virus infections. IMPORTANCE Human adenoviruses (HAdVs) are common pathogens causing a wide range of diseases. To achieve pathogenicity, HAdVs have to counteract a variety of host cell antiviral defense systems, which would otherwise hamper virus replication. In this study, we show that the HAdV-C5 histone-like core protein pVII binds to and promotes self-ubiquitination of a cellular E3 ubiquitin ligase named MKRN1. This mutual interaction between the pVII and

  12. The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.

    Science.gov (United States)

    Bharaj, Preeti; Atkins, Colm; Luthra, Priya; Giraldo, Maria Isabel; Dawes, Brian E; Miorin, Lisa; Johnson, Jeffrey R; Krogan, Nevan J; Basler, Christopher F; Freiberg, Alexander N; Rajsbaum, Ricardo

    2017-09-15

    Ebola virus (EBOV), a member of the Filoviridae family, is a highly pathogenic virus that causes severe hemorrhagic fever in humans and is responsible for epidemics throughout sub-Saharan, central, and West Africa. The EBOV genome encodes VP35, an important viral protein involved in virus replication by acting as an essential cofactor of the viral polymerase as well as a potent antagonist of the host antiviral type I interferon (IFN-I) system. By using mass spectrometry analysis and coimmunoprecipitation assays, we show here that VP35 is ubiquitinated on lysine 309 (K309), a residue located on its IFN antagonist domain. We also found that VP35 interacts with TRIM6, a member of the E3-ubiquitin ligase tripartite motif (TRIM) family. We recently reported that TRIM6 promotes the synthesis of unanchored K48-linked polyubiquitin chains, which are not covalently attached to any protein, to induce efficient antiviral IFN-I-mediated responses. Consistent with this notion, VP35 also associated noncovalently with polyubiquitin chains and inhibited TRIM6-mediated IFN-I induction. Intriguingly, we also found that TRIM6 enhances EBOV polymerase activity in a minigenome assay and TRIM6 knockout cells have reduced replication of infectious EBOV, suggesting that VP35 hijacks TRIM6 to promote EBOV replication through ubiquitination. Our work provides evidence that TRIM6 is an important host cellular factor that promotes EBOV replication, and future studies will focus on whether TRIM6 could be targeted for therapeutic intervention against EBOV infection. IMPORTANCE EBOV belongs to a family of highly pathogenic viruses that cause severe hemorrhagic fever in humans and other mammals with high mortality rates (40 to 90%). Because of its high pathogenicity and lack of licensed antivirals and vaccines, EBOV is listed as a tier 1 select-agent risk group 4 pathogen. An important mechanism for the severity of EBOV infection is its suppression of innate immune responses. The EBOV VP35

  13. E0 transitions in {sup 106}Pd: Implications for shape coexistence

    Energy Technology Data Exchange (ETDEWEB)

    Peters, E.E.; Mynk, M.G. [University of Kentucky, Department of Chemistry, Lexington, KY (United States); Prados-Estevez, F.M.; Chakraborty, A.; Yates, S.W. [University of Kentucky, Department of Chemistry, Lexington, KY (United States); University of Kentucky, Department of Physics and Astronomy, Lexington, KY (United States); Bandyopadhyay, D.; Choudry, S.N.; Crider, B.P.; Kumar, A.; Lesher, S.R.; McKay, C.J.; Orce, J.N.; Scheck, M. [University of Kentucky, Department of Physics and Astronomy, Lexington, KY (United States); Garrett, P.E. [University of Guelph, Department of Physics, Guelph, Ontario (Canada); Hicks, S.F. [University of Dallas, Department of Physics, Irving, TX (United States); Vanhoy, J.R. [United States Naval Academy, Department of Physics, Annapolis, MD (United States); Wood, J.L. [Georgia Institute of Technology, School of Physics, Atlanta, GA (United States)

    2016-04-15

    Level lifetimes in {sup 106}Pd were measured with the Doppler-shift attenuation method following inelastic neutron scattering, and electric monopole transition strengths between low-lying 2{sup +} states were deduced. The large ρ{sup 2} (E0) values obtained provide evidence for shape coexistence, extending observation of such structures in the N = 60 isotones. Included in these results is the first determination of the E0 transition strength in the Pd nuclei between levels with K = 2. (orig.)

  14. Strength of mortar containing rubber tire particle

    Science.gov (United States)

    Jusoh, M. A.; Abdullah, S. R.; Adnan, S. H.

    2018-04-01

    The main focus in this investigation is to determine the strength consist compressive and tensile strength of mortar containing rubber tire particle. In fact, from the previous study, the strength of mortar containing waste rubber tire in mortar has a slightly decreases compare to normal mortar. In this study, rubber tire particle was replacing on volume of fine aggregate with 6%. 9% and 12%. The sample were indicated M0 (0%), M6 (6%), M9 (9%) and M12 (12%). In this study, two different size of sample used with cube 100mm x 100mm x 100mm for compressive strength and 40mm x 40mm x 160mm for flexural strength. Morphology test was conducted by using Scanning electron microscopic (SEM) were done after testing compressive strength test. The concrete sample were cured for day 3, 7 and 28 before testing. Results compressive strength and flexural strength of rubber mortar shown improved compare to normal mortar.

  15. optimizing compressive strength characteristics of hollow building

    African Journals Online (AJOL)

    eobe

    Keywords: hollow building Blocks, granite dust, sand, partial replacement, compressive strength. 1. INTRODUCTION ... exposed to extreme climate. The physical ... Sridharan et al [13] conducted shear strength studies on soil-quarry dust.

  16. Elastic buckling strength of corroded steel plates

    Indian Academy of Sciences (India)

    structural safety assessment of corroded structures, residual strength should be ... Rahbar-Ranji (2001) has proposed a spectrum for random simulation of ... The main aim of the present work is to investigate the buckling strength of simply ...

  17. CADDIS Volume 2. Sources, Stressors and Responses: Ionic Strength

    Science.gov (United States)

    Introduction to the ionic strength module, when to list ionic strength as a candidate cause, ways to measure ionic strength, simple and detailed conceptual diagrams for ionic strength, ionic strength module references and literature reviews.

  18. Exploring and Leveraging Chinese International Students' Strengths for Success

    Science.gov (United States)

    He, Ye; Hutson, Bryant

    2018-01-01

    This study used an Appreciative Education framework to explore the strengths of Chinese international students and to identify areas where support is needed during their transition to U.S. higher education settings. Using a convergent mixed methods design with data collected from surveys, interviews and focus groups, the complex nature of the…

  19. Electron impact excitation collision strengths for neon-like Ni XIX ...

    Indian Academy of Sciences (India)

    Abstract. In a recent paper [Pramana – J. Phys. 64, 129 (2005)] results have been presented for electron impact excitation collision strengths for transitions among the fine- structure levels of the 2s22p6 and 2s22p53s configurations of Ni XIX. In this paper we demonstrate through an independent calculation with the ...

  20. Electron impact excitation collision strengths for neon-like Ni XIX ...

    Indian Academy of Sciences (India)

    In a recent paper [Pramana - J. Phys. 64, 129 (2005)] results have been presented for electron impact excitation collision strengths for transitions among the fine-structure levels of the 2s22p6 and 2s22p53s configurations of Ni XIX. In this paper we demonstrate through an independent calculation with the relativistic -matrix ...

  1. Postsecondary Strengths, Challenges, and Supports Experienced by Foster Care Alumni College Graduates

    Science.gov (United States)

    Salazar, Amy M.; Jones, Kevin R.; Emerson, John C.; Mucha, Lauren

    2016-01-01

    Young people transitioning from foster care to college experience unique identities and circumstances that make being successful in college especially challenging. We used qualitative survey data from 248 college graduates who were formerly in foster care to explore the strengths, challenges, and supports they experienced while in college that…

  2. Photon strength function in the Hf-181 nucleus by method of two-step cascade

    International Nuclear Information System (INIS)

    Le Hong Khiem

    2003-01-01

    The applicability of sum-coincidence measurements of two-step cascade gamma ray spectra determining Photon Strength Function (PSF) of Hf-181 induced from Hf-180 (n,2γ) Hf-181 reaction is presented. Up to 80% intensity of the primary gamma ray transitions in a wide energy range have been deduced and compared to model calculation. (author)

  3. Role of the momentum transfer in the quenching of the Gamow-Teller strength

    Energy Technology Data Exchange (ETDEWEB)

    Marketin, Tomislav [Institut fuer Kernphysik, Technische Universitaet Darmstadt (Germany); Physics Department, Faculty of Science, University of Zagreb (Croatia); Martinez-Pinedo, Gabriel [Institut fuer Kernphysik, Technische Universitaet Darmstadt (Germany); Paar, Nils; Vretenar, Dario [Physics Department, Faculty of Science, University of Zagreb (Croatia)

    2012-07-01

    A fully consistent calculation of the Gamow-Teller strength is presented, based on a microscopic theoretical framework. Nuclear ground state is determined using the relativistic Hartree-Bogolyubov (RHB) model with density dependent meson-nucleon coupling constants, and transition rates are calculated via proton-neutron relativistic quasiparticle RPA using the same interaction as in the RHB equations. The (p,n) probe has a similar spin-isospin operator structure to the Gamow-Teller (GT) operator. However, they become comparable only if the GT cross section is measured at a very small momentum transfer q. At higher momentum transfer the isovector spin monopole (IVSM) mode occurs, with the r{sup 2}{sigma}{tau} transition operator. Unlike the Gamow-Teller operator which excites only the 0{Dirac_h}{omega} transitions, the isovector spin monopole operator can also excite 2{Dirac_h}{omega} transitions and can change the strength distribution at high excitation energies. We explore the strength beyond the resonance, examine the effect of momentum transfer on the total strength and compare the results with recent measurements.

  4. Determination of giant resonance strengths

    International Nuclear Information System (INIS)

    Serr, F.E.

    1983-01-01

    Using theoretical strength functions to describe the different giant resonances expected at excitation energies of the order of (60-85)/Asup(1/3) MeV, we calculate the double differential cross sections d 2 sigma/dΩ dE associated with the reactions 208 Pb(α, α') and 90 Zr(α, α') (Esub(α) = 152 MeV). The angular distributions for the giant quadrupole and giant monopole resonances obtained from fits to these spectra, making simple, commonly used assumptions for the peak shapes and background, are compared to the original angular distributions. The differences between them are an indication of some of the uncertainties affecting the giant resonance strengths extracted from hadron inelastic scattering data. Fits to limited angular regions lead to errors of up to 50% in the value of the energy-weighted sum rule, depending on the angles examined. While it seems possible to extract the correct EWSR for the GMR by carrying out the analyses at 0 0 , no single privileged angle seems to exist in the case of the GQR. (orig.)

  5. RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.

    Science.gov (United States)

    Feeney, Laura; Muñoz, Ivan M; Lachaud, Christophe; Toth, Rachel; Appleton, Paul L; Schindler, Detlev; Rouse, John

    2017-06-01

    Defects in the repair of DNA interstrand crosslinks (ICLs) are associated with the genome instability syndrome Fanconi anemia (FA). Here we report that cells with mutations in RFWD3, an E3 ubiquitin ligase that interacts with and ubiquitylates replication protein A (RPA), show profound defects in ICL repair. An amino acid substitution in the WD40 repeats of RFWD3 (I639K) found in a new FA subtype abolishes interaction of RFWD3 with RPA, thereby preventing RFWD3 recruitment to sites of ICL-induced replication fork stalling. Moreover, single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit ICL repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair. We also report that unloading of RPA from sites of ICL induction is perturbed in RFWD3-deficient cells. These data reveal important roles for RFWD3 localization in protecting genome stability and preserving human health. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  6. A new lunar absolute control point: established by images from the landing camera on Chang'e-3

    International Nuclear Information System (INIS)

    Wang Fen-Fei; Liu Jian-Jun; Li Chun-Lai; Ren Xin; Mu Ling-Li; Yan Wei; Wang Wen-Rui; Xiao Jing-Tao; Tan Xu; Zhang Xiao-Xia; Zou Xiao-Duan; Gao Xing-Ye

    2014-01-01

    The establishment of a lunar control network is one of the core tasks in selenodesy, in which defining an absolute control point on the Moon is the most important step. However, up to now, the number of absolute control points has been very sparse. These absolute control points have mainly been lunar laser ranging retroreflectors, whose geographical location can be observed by observations on Earth and also identified in high resolution lunar satellite images. The Chang'e-3 (CE-3) probe successfully landed on the Moon, and its geographical location has been monitored by an observing station on Earth. Since its positional accuracy is expected to reach the meter level, the CE-3 landing site can become a new high precision absolute control point. We use a sequence of images taken from the landing camera, as well as satellite images taken by CE-1 and CE-2, to identify the location of the CE-3 lander. With its geographical location known, the CE-3 landing site can be established as a new absolute control point, which will effectively expand the current area of the lunar absolute control network by 22%, and can greatly facilitate future research in the field of lunar surveying and mapping, as well as selenodesy

  7. FUSION OF MULTI-SCALE DEMS FROM DESCENT AND NAVCM IMAGES OF CHANG’E-3 USING COMPRESSED SENSING METHOD

    Directory of Open Access Journals (Sweden)

    M. Peng

    2017-07-01

    Full Text Available The multi-source DEMs generated using the images acquired in the descent and landing phase and after landing contain supplementary information, and this makes it possible and beneficial to produce a higher-quality DEM through fusing the multi-scale DEMs. The proposed fusion method consists of three steps. First, source DEMs are split into small DEM patches, then the DEM patches are classified into a few groups by local density peaks clustering. Next, the grouped DEM patches are used for sub-dictionary learning by stochastic coordinate coding. The trained sub-dictionaries are combined into a dictionary for sparse representation. Finally, the simultaneous orthogonal matching pursuit (SOMP algorithm is used to achieve sparse representation. We use the real DEMs generated from Chang’e-3 descent images and navigation camera (Navcam stereo images to validate the proposed method. Through the experiments, we have reconstructed a seamless DEM with the highest resolution and the largest spatial coverage among the input data. The experimental results demonstrated the feasibility of the proposed method.

  8. Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair

    International Nuclear Information System (INIS)

    Ouyang, Yan; Kwon, Yong Tae; An, Jee Young; Eller, Danny; Tsai, S.-C.; Diaz-Perez, Silvia; Troke, Joshua J.; Teitell, Michael A.; Marahrens, York

    2006-01-01

    The N-end rule pathway of protein degradation targets proteins with destabilizing N-terminal residues. Ubr2 is one of the E3 ubiquitin ligases of the mouse N-end rule pathway. We have previously shown that Ubr2 -/- male mice are infertile, owing to the arrest of spermatocytes between the leptotene/zygotene and pachytene of meiosis I, the failure of chromosome pairing, and subsequent apoptosis. Here, we report that mouse fibroblast cells derived from Ubr2 -/- embryos display genome instability. The frequency of chromosomal bridges and micronuclei were much higher in Ubr2 -/- fibroblasts than in +/+ controls. Metaphase chromosome spreads from Ubr2 -/- cells revealed a high incidence of spontaneous chromosomal gaps, indicating chromosomal fragility. These fragile sites were generally replicated late in S phase. Ubr2 -/- cells were hypersensitive to mitomycin C, a DNA cross-linking agent, but displayed normal sensitivity to gamma-irradiation. A reporter assay showed that Ubr2 -/- cells are significantly impaired in the homologous recombination repair of a double strand break. In contrast, Ubr2 -/- cells appeared normal in an assay for non-homologous end joining. Our results therefore unveil the role of the ubiquitin ligase Ubr2 in maintaining genome integrity and in homologous recombination repair

  9. Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair

    Energy Technology Data Exchange (ETDEWEB)

    Ouyang, Yan [Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Kwon, Yong Tae [Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261 (United States); An, Jee Young [Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261 (United States); Eller, Danny [Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Tsai, S.-C. [Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Diaz-Perez, Silvia [Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Troke, Joshua J. [Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Teitell, Michael A. [Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States); Marahrens, York [Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 (United States)]. E-mail: ymarahrens@mednet.ucla.edu

    2006-04-11

    The N-end rule pathway of protein degradation targets proteins with destabilizing N-terminal residues. Ubr2 is one of the E3 ubiquitin ligases of the mouse N-end rule pathway. We have previously shown that Ubr2{sup -/-} male mice are infertile, owing to the arrest of spermatocytes between the leptotene/zygotene and pachytene of meiosis I, the failure of chromosome pairing, and subsequent apoptosis. Here, we report that mouse fibroblast cells derived from Ubr2{sup -/-} embryos display genome instability. The frequency of chromosomal bridges and micronuclei were much higher in Ubr2{sup -/-} fibroblasts than in +/+ controls. Metaphase chromosome spreads from Ubr2{sup -/-} cells revealed a high incidence of spontaneous chromosomal gaps, indicating chromosomal fragility. These fragile sites were generally replicated late in S phase. Ubr2{sup -/-} cells were hypersensitive to mitomycin C, a DNA cross-linking agent, but displayed normal sensitivity to gamma-irradiation. A reporter assay showed that Ubr2{sup -/-} cells are significantly impaired in the homologous recombination repair of a double strand break. In contrast, Ubr2{sup -/-} cells appeared normal in an assay for non-homologous end joining. Our results therefore unveil the role of the ubiquitin ligase Ubr2 in maintaining genome integrity and in homologous recombination repair.

  10. A method and results of color calibration for the Chang'e-3 terrain camera and panoramic camera

    International Nuclear Information System (INIS)

    Ren Xin; Li Chun-Lai; Liu Jian-Jun; Wang Fen-Fei; Yang Jian-Feng; Xue Bin; Liu En-Hai; Zhao Ru-Jin

    2014-01-01

    The terrain camera (TCAM) and panoramic camera (PCAM) are two of the major scientific payloads installed on the lander and rover of the Chang'e 3 mission respectively. They both use a Bayer color filter array covering CMOS sensor to capture color images of the Moon's surface. RGB values of the original images are related to these two kinds of cameras. There is an obvious color difference compared with human visual perception. This paper follows standards published by the International Commission on Illumination to establish a color correction model, designs the ground calibration experiment and obtains the color correction coefficient. The image quality has been significantly improved and there is no obvious color difference in the corrected images. Ground experimental results show that: (1) Compared with uncorrected images, the average color difference of TCAM is 4.30, which has been reduced by 62.1%. (2) The average color differences of the left and right cameras in PCAM are 4.14 and 4.16, which have been reduced by 68.3% and 67.6% respectively

  11. Parameters and structure of lunar regolith in Chang'E-3 landing area from lunar penetrating radar (LPR) data

    Science.gov (United States)

    Dong, Zehua; Fang, Guangyou; Ji, Yicai; Gao, Yunze; Wu, Chao; Zhang, Xiaojuan

    2017-01-01

    Chang'E-3 (CE-3) landed in the northwest Mare Imbrium, a region that has not been explored before. Yutu rover that released by CE-3 lander carried the first lunar surface penetrating radar (LPR) for exploring lunar regolith thickness and subsurface shallow geological structures. In this paper, based on the LPR data and the Panoramic Camera (PC) data, we first calculate the lunar surface regolith parameters in CE-3 landing area including its permittivity, density, conductivity and FeO + TiO2 content. LPR data provides a higher spatial resolution and more accuracy for the lunar regolith parameters comparing to other remote sensing techniques, such as orbit radar sounder and microwave sensing or earth-based powerful radar. We also derived the regolith thickness and its weathered rate with much better accuracy in the landing area. The results indicate that the regolith growth rate is much faster than previous estimation, the regolith parameters are not uniform even in such a small study area and the thickness and growth rate of lunar regolith here are different from other areas in Mare Imbrium. We infer that the main reason should be geological deformation that caused by multiple impacts of meteorites in different sizes.

  12. Dielectric constant and low-frequency infrared spectra for liquid water and ice Ih within the E3B model

    Energy Technology Data Exchange (ETDEWEB)

    Shi, L.; Ni, Y.; Drews, S. E. P.; Skinner, J. L. [Theoretical Chemistry Institute and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706 (United States)

    2014-08-28

    Two intrinsic difficulties in modeling condensed-phase water with conventional rigid non-polarizable water models are: reproducing the static dielectric constants for liquid water and ice Ih, and generating the peak at about 200 cm{sup −1} in the low-frequency infrared spectrum for liquid water. The primary physical reason for these failures is believed to be the missing polarization effect in these models, and consequently various sophisticated polarizable water models have been developed. However, in this work we pursue a different strategy and propose a simple empirical scheme to include the polarization effect only on the dipole surface (without modifying a model's intermolecular interaction potential). We implement this strategy for our explicit three-body (E3B) model. Our calculated static dielectric constants and low-frequency infrared spectra are in good agreement with experiment for both liquid water and ice Ih over wide temperature ranges, albeit with one fitting parameter for each phase. The success of our modeling also suggests that thermal fluctuations about local minima and the energy differences between different proton-disordered configurations play minor roles in the static dielectric constant of ice Ih. Our analysis shows that the polarization effect is important in resolving the two difficulties mentioned above and sheds some light on the origin of several features in the low-frequency infrared spectra for liquid water and ice Ih.

  13. E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia

    Directory of Open Access Journals (Sweden)

    Bill B. Chen

    2014-04-01

    Full Text Available Acute lung injury (ALI is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generated by cardiolipin synthase (CLS1. Here, we show that S. aureus activates a ubiquitin E3 ligase component, Fbxo15, that is sufficient to mediate proteasomal degradation of CLS1 in epithelia, resulting in decreased cardiolipin availability and disrupted mitochondrial function. CLS1 is destabilized by the phosphatase and tensin homolog (PTEN-induced putative kinase 1 (PINK1, which binds CLS1 to phosphorylate and regulates CLS1 disposal. Like Fbxo15, PINK1 interacts with and regulates levels of CLS1 through a mechanism dependent upon Thr219. S. aureus infection upregulates this Fbxo15-PINK1 pathway to impair mitochondrial integrity, and Pink1 knockout mice are less prone to S. aureus-induced ALI. Thus, ALI-associated disruption of cellular bioenergetics involves bioeffectors that utilize a phosphodegron to elicit ubiquitin-mediated disposal of a key mitochondrial enzyme.

  14. Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA

    Science.gov (United States)

    Yunus, Ali A.; Lima, Christopher D.

    2009-01-01

    Summary Siz1 is a founding member of the Siz/PIAS RING family of SUMO E3 ligases. The x-ray structure of an active Siz1 ligase revealed an elongated tripartite architecture comprised of an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain we term the SP-CTD. Structure-based mutational analysis and biochemical studies show that the SP-RING and SP-CTD are required for activation of the E2~SUMO thioester while the PINIT domain is essential for redirecting SUMO conjugation to the proliferating cell nuclear antigen (PCNA) at lysine 164, a non-consensus lysine residue that is not modified by the SUMO E2 in the absence of Siz1. Mutational analysis of Siz1 and PCNA revealed surfaces on both proteins that are required for efficient SUMO modification of PCNA in vitro and in vivo. PMID:19748360

  15. LOSS OF JAK2 REGULATION VIA VHL-SOCS1 E3 UBIQUITIN HETEROCOMPLEX UNDERLIES CHUVASH POLYCYTHEMIA

    Science.gov (United States)

    Russell, Ryan C.; Sufan, Roxana I.; Zhou, Bing; Heir, Pardeep; Bunda, Severa; Sybingco, Stephanie S.; Greer, Samantha N.; Roche, Olga; Heathcote, Samuel A.; Chow, Vinca W.K.; Boba, Lukasz M.; Richmond, Terri D.; Hickey, Michele M.; Barber, Dwayne L.; Cheresh, David A.; Simon, M. Celeste; Irwin, Meredith S.; Kim, William Y.; Ohh, Michael

    2011-01-01

    SUMMARY Chuvash polycythemia (CP) is a rare congenital form of polycythemia caused by homozygous R200W and H191D mutations in the von Hippel-Lindau (VHL) gene whose gene product is the principal negative regulator of hypoxia-inducible factor. However, the molecular mechanisms underlying some of the hallmark features of CP such as hypersensitivity to erythropoietin are unclear. Here, we show that VHL directly binds suppressor of cytokine signalling 1 (SOCS1) to form a heterodimeric E3 ligase that targets phosphorylated (p)JAK2 for ubiquitin-mediated destruction. In contrast, CP-associated VHL mutants have altered affinity for SOCS1 and fail to engage and degrade pJAK2. Systemic administration of a highly selective JAK2 inhibitor, TG101209, reverses the disease phenotype in vhlR200W/R200W knock-in mice, a model that faithfully recapitulates human CP. These results reveal VHL as a SOCS1-cooperative negative regulator of JAK2 and provide compelling biochemical and preclinical evidence for JAK2- targeted therapy in CP patients. PMID:21685897

  16. The Arabidopsis E3 Ubiquitin Ligase HOS1 Negatively Regulates CONSTANS Abundance in the Photoperiodic Control of Flowering[W

    Science.gov (United States)

    Lazaro, Ana; Valverde, Federico; Piñeiro, Manuel; Jarillo, Jose A.

    2012-01-01

    The Arabidopsis thaliana early in short days6 (esd6) mutant was isolated in a screen for mutations that accelerate flowering time. Among other developmental alterations, esd6 displays early flowering in both long- and short-day conditions. Fine mapping of the mutation showed that the esd6 phenotype is caused by a lesion in the HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 (HOS1) locus, which encodes a RING finger–containing E3 ubiquitin ligase. The esd6/hos1 mutation causes decreased FLOWERING LOCUS C expression and requires CONSTANS (CO) protein for its early flowering phenotype under long days. Moreover, CO and HOS1 physically interact in vitro and in planta, and HOS1 regulates CO abundance, particularly during the daylight period. Accordingly, hos1 causes a shift in the regular long-day pattern of expression of FLOWERING LOCUS T (FT) transcript, starting to rise 4 h after dawn in the mutant. In addition, HOS1 interacts synergistically with CONSTITUTIVE PHOTOMORPHOGENIC1, another regulator of CO protein stability, in the regulation of flowering time. Taken together, these results indicate that HOS1 is involved in the control of CO abundance, ensuring that CO activation of FT occurs only when the light period reaches a certain length and preventing precocious flowering in Arabidopsis. PMID:22408073

  17. A method and results of color calibration for the Chang'e-3 terrain camera and panoramic camera

    Science.gov (United States)

    Ren, Xin; Li, Chun-Lai; Liu, Jian-Jun; Wang, Fen-Fei; Yang, Jian-Feng; Liu, En-Hai; Xue, Bin; Zhao, Ru-Jin

    2014-12-01

    The terrain camera (TCAM) and panoramic camera (PCAM) are two of the major scientific payloads installed on the lander and rover of the Chang'e 3 mission respectively. They both use a Bayer color filter array covering CMOS sensor to capture color images of the Moon's surface. RGB values of the original images are related to these two kinds of cameras. There is an obvious color difference compared with human visual perception. This paper follows standards published by the International Commission on Illumination to establish a color correction model, designs the ground calibration experiment and obtains the color correction coefficient. The image quality has been significantly improved and there is no obvious color difference in the corrected images. Ground experimental results show that: (1) Compared with uncorrected images, the average color difference of TCAM is 4.30, which has been reduced by 62.1%. (2) The average color differences of the left and right cameras in PCAM are 4.14 and 4.16, which have been reduced by 68.3% and 67.6% respectively.

  18. Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.

    Directory of Open Access Journals (Sweden)

    Roland Le Borgne

    2005-04-01

    Full Text Available Signaling by the Notch ligands Delta (Dl and Serrate (Ser regulates a wide variety of essential cell-fate decisions during animal development. Two distinct E3 ubiquitin ligases, Neuralized (Neur and Mind bomb (Mib, have been shown to regulate Dl signaling in Drosophila melanogaster and Danio rerio, respectively. While the neur and mib genes are evolutionarily conserved, their respective roles in the context of a single organism have not yet been examined. We show here that the Drosophila mind bomb (D-mib gene regulates a subset of Notch signaling events, including wing margin specification, leg segmentation, and vein determination, that are distinct from those events requiring neur activity. D-mib also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting that D-mib regulates Dl signaling. During wing development, expression of D-mib in dorsal cells appears to be necessary and sufficient for wing margin specification, indicating that D-mib also regulates Ser signaling. Moreover, the activity of the D-mib gene is required for the endocytosis of Ser in wing imaginal disc cells. Finally, ectopic expression of neur in D-mib mutant larvae rescues the wing D-mib phenotype, indicating that Neur can compensate for the lack of D-mib activity. We conclude that D-mib and Neur are two structurally distinct proteins that have similar molecular activities but distinct developmental functions in Drosophila.

  19. The E3 Ubiquitin Ligase MIB-1 Is Necessary To Form the Nuclear Halo in Caenorhabditis elegans Sperm.

    Science.gov (United States)

    Herrera, Leslie A; Starr, Daniel A

    2018-05-18

    Unlike the classical nuclear envelope with two membranes found in other eukaryotic cells, most nematode sperm nuclei are not encapsulated by membranes. Instead, they are surrounded by a nuclear halo of unknown composition. How the halo is formed and regulated is unknown. We used forward genetics to identify molecular lesions behind three classical fer (fertilization defective) mutations that disrupt the ultrastructure of the Caenorhabditis elegans sperm nuclear halo. We found fer-2 and fer-4 alleles to be nonsense mutations in mib-1. fer-3 was caused by a nonsense mutation in eri-3 GFP::MIB-1 was expressed in the germline during early spermatogenesis, but not in mature sperm. mib-1 encodes a conserved E3 ubiquitin ligase homologous to vertebrate Mib1 and Mib2, which function in Notch signaling. Here, we show that mib-1 is important for male sterility and is involved in the regulation or formation of the nuclear halo during nematode spermatogenesis. Copyright © 2018, G3: Genes, Genomes, Genetics.

  20. Strengths and Satisfaction across the Adult Lifespan

    Science.gov (United States)

    Isaacowitz, Derek M.; Vaillant, George E.; Seligman, Martin E. P.

    2003-01-01

    Positive psychology has recently developed a classification of human strengths (Peterson & Seligman, in press). We aimed to evaluate these strengths by investigating the strengths and life satisfaction in three adult samples recruited from the community (young adult, middle-aged, and older adult), as well as in the surviving men of the Grant study…

  1. Relationship between the edgewise compression strength of ...

    African Journals Online (AJOL)

    The results of this study were used to determine the linear regression constants in the Maltenfort model by correlating the measured board edgewise compression strength (ECT) with the predicted strength, using the paper components' compression strengths, measured with the short-span compression test (SCT) and the ...

  2. Strength of Ship Plates under Combined Loading

    DEFF Research Database (Denmark)

    Cui, W.; Wang, Y.; Pedersen, Preben Terndrup

    2002-01-01

    Strength of ship plates plays a significant role in the ultimate strength analysis of ship structures. In recent years several authors have proposed simplified analytical methods to calculate the ultimate strength of unstiffened plates. The majority of these investigations deal with plates subjec...

  3. Strength of ship plates under combined loading

    DEFF Research Database (Denmark)

    Cui, Weiching; Wang, Yongjun; Pedersen, Preben Terndrup

    2000-01-01

    Strength of ship plates plays a significant role for the ultimate strength analysis of ship structures. In recent years several authors have proposed simplified methods to calculate the ultimate strength of unstiffened plates. The majority of these investigations deal with plates subjected to lon...

  4. Microscopic analysis of order parameters in nuclear quantum phase transitions

    International Nuclear Information System (INIS)

    Li, Z. P.; Niksic, T.; Vretenar, D.; Meng, J.

    2009-01-01

    Microscopic signatures of nuclear ground-state shape phase transitions in Nd isotopes are studied using excitation spectra and collective wave functions obtained by diagonalization of a five-dimensional Hamiltonian for quadrupole vibrational and rotational degrees of freedom, with parameters determined by constrained self-consistent relativistic mean-field calculations for triaxial shapes. As a function of the physical control parameter, the number of nucleons, energy gaps between the ground state and the excited vibrational states with zero angular momentum, isomer shifts, and monopole transition strengths exhibit sharp discontinuities at neutron number N=90, which is characteristic of a first-order quantum phase transition.

  5. 29 CFR 550.1 - “Talent fees” as used in section 7(e)(3)(c) of the Fair Labor Standards Act, as amended.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false âTalent feesâ as used in section 7(e)(3)(c) of the Fair...) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND DELIMITING THE TERM âTALENT FEESâ § 550.1 “Talent fees” as used in section 7(e)(3)(c) of the Fair Labor Standards Act, as amended. The...

  6. Gamow-Teller Strengths from (3He,t) Charge-Exchange Reaction

    International Nuclear Information System (INIS)

    Fujita, Yoshitaka

    2006-01-01

    Gamow-Teller (GT) transition is the most popular nuclear weak process with the nature of spin-isospin excitation. GT transitions in pf-shell nuclei, including those starting from unstable nuclei, are of interest, due to their importance in astrophysical processes. Weak processes, however, gives us rather limited information on the GT response of nuclei. We introduce high-resolution ( 3 He, t) reaction at 0 0 and at an intermediate beam energy as a new spectroscopic tool for studying GT excitations. Owing to the high energy-resolution of the reaction (∼ 30 keV), individual transitions can be observed up to the region of GT giant resonance. Assuming isospin symmetry for the T z = ±1 → 0 isobaric analogous transitions in isobars with mass number A, we present a new method to deduce GT transition strengths starting from proton rich exotic nuclei

  7. NR2E3 mutations in enhanced S-cone sensitivity syndrome (ESCS), Goldmann-Favre syndrome (GFS), clumped pigmentary retinal degeneration (CPRD), and retinitis pigmentosa (RP).

    Science.gov (United States)

    Schorderet, Daniel F; Escher, Pascal

    2009-11-01

    NR2E3, also called photoreceptor-specific nuclear receptor (PNR), is a transcription factor of the nuclear hormone receptor superfamily whose expression is uniquely restricted to photoreceptors. There, its physiological activity is essential for proper rod and cone photoreceptor development and maintenance. Thirty-two different mutations in NR2E3 have been identified in either homozygous or compound heterozygous state in the recessively inherited enhanced S-cone sensitivity syndrome (ESCS), Goldmann-Favre syndrome (GFS), and clumped pigmentary retinal degeneration (CPRD). The clinical phenotype common to all these patients is night blindness, rudimental or absent rod function, and hyperfunction of the "blue" S-cones. A single p.G56R mutation is inherited in a dominant manner and causes retinitis pigmentosa (RP). We have established a new locus-specific database for NR2E3 (www.LOVD.nl/eye), containing all reported mutations, polymorphisms, and unclassified sequence variants, including novel ones. A high proportion of mutations are located in the evolutionarily-conserved DNA-binding domains (DBDs) and ligand-binding domains (LBDs) of NR2E3. Based on homology modeling of these NR2E3 domains, we propose a structural localization of mutated residues. The high variability of clinical phenotypes observed in patients affected by NR2E3-linked retinal degenerations may be caused by different disease mechanisms, including absence of DNA-binding, altered interactions with transcriptional coregulators, and differential activity of modifier genes.

  8. Workers in transition

    OpenAIRE

    Rutkowski, Michael

    1995-01-01

    After Central and Eastern European and Central Asian economies abandoned central planning, nearly 195 million workers had to adjust to new rules of work and life. Most transition economies have not yet fully committed themselves to the rules of the market place. A few that have are already enjoying growth in wages and employment; in other countries, labor income growth is still to come. Reform has not been so well accepted in countries that were forced to enter the transition. Transition brou...

  9. Transition and Social networks

    OpenAIRE

    Raghavan, Raghu; Pawson, N.

    2011-01-01

    School leavers with learning disabilities often face difficulties in making a smooth transition from school to college, employment or more broadly, to adult life. The transition phase is traumatic for the young person with learning disabilities and their families as it often results in the loss of friendships, relationships and social networks. The aim of this chapter is to explore the issues of transition from adolescence to adulthood for young people with learning disabilities and its effe...

  10. Thermodynamics of phase transitions

    International Nuclear Information System (INIS)

    Cofta, H.

    1972-01-01

    The phenomenology of the phase transitions has been considered. The definitions of thermodynamic functions and parameters, as well as those of the phase transitions, are given and some of the relations between those quantities are discussed. The phase transitions classification proposed by Ehrenfest has been described. The most important features of phase transitions are discussed using the selected physical examples including the critical behaviour of ferromagnetic materials at the Curie temperature and antiferromagnetic materials at the Neel temperature. Some aspects of the Ehrenfest's equations, that have been derived, for the interfacial lines and surfaces are considered as well as the role the notion of interfaces. (S.B.)

  11. The Energy Transition Chronicles

    International Nuclear Information System (INIS)

    Cappelletti, Floriane; Vallar, Jean-Pierre; Wyssling, Julia

    2015-01-01

    Energy Cities provides local authorities with support for implementing their own energy transition process. The Proposals for the energy transition of cities and towns (www.energy-cities.eu/30proposals) are illustrated with around a hundred of inspirational examples from all over Europe. In this document composed of five case reports, Energy Cities goes further and tells the tale of energy transition success stories. Because it is important to show that energy transition is 'possible'. Why, how, with whom, for what results? We interviewed local players and decision-makers to find out more. Here are their stories

  12. Transit Benefit Program Data -

    Data.gov (United States)

    Department of Transportation — This data set contains information about any US government agency participating in the transit benefits program, funding agreements, individual participating Federal...

  13. Collision strengths for the excitation of lithium- and boron-like ions by electron impact

    International Nuclear Information System (INIS)

    Goett, S.J.

    1983-01-01

    The theory of collision strengths of highly charged ions is presented in terms of the R-matrix formalism by utilizing time-dependent perturbation theory. This theory is then applied to the general case of an ion with three valence electrons. The theory is general enough to admit the possiblity of three equivalent electrons. The effects of configuration interaction and intermediate coupling are incorporated through the mixing coefficients calculated by diagonalizing the perturbation matrix. This matrix is formed by taking into account the electron-electron electrostatic interaction as well as all first order relativistic corrections. The dipole radiative line strengths are also calculated using these mix coefficients. The line strengths are needed for the Coulomb-Bethe approximation which estimates the contributions to the collision strengths from large values of the impact electron's orbital angular momentum. All the above quantities are calculated in both the LS and jj coupling schemes. This dual calculation provides useful information about the mixing of the states present, as well as serving as a valuable check on the development of the theory and the coding of the computer programs. An application is made to the calculation of transition energies, line strengths and collision strengths of transitions from all lower states with a configuration of 1s 2 2I to all upper states with a configuraiton of 1s2I/sub a/'2I/sub b/'

  14. Ginsburg-Landau equation around the superconductor-insulator transition

    International Nuclear Information System (INIS)

    Ng, T.K.

    1991-01-01

    Based on the scaling theory of localization, we construct a Ginsburg-Landau (GL) equation for superconductors in an arbitrary strength of disordered potential. Using this GL equation, we reexamine the criteria for the superconductor-insulator transition and find that the transition to a localized superconductor can happen on both sides of the (normal) metal-insulator transition, in contrast to a previous prediction by Ma and Lee [Phys. Rev. B 32, 5658 (1985)] that the transition can only be on the insulator side. Furthermore, by comparing our theory with a recent scaling theory of dirty bosons by Fisher et al. [Phys. Rev. Lett. 64, 587 (1990)], we conclude that nontrivial crossover behavior in transport properties may occur in the vicinity of the superconductor-insulator transition

  15. Cobalt: for strength and color

    Science.gov (United States)

    Boland, Maeve A.; Kropschot, S.J.

    2011-01-01

    Cobalt is a shiny, gray, brittle metal that is best known for creating an intense blue color in glass and paints. It is frequently used in the manufacture of rechargeable batteries and to create alloys that maintain their strength at high temperatures. It is also one of the essential trace elements (or "micronutrients") that humans and many other living creatures require for good health. Cobalt is an important component in many aerospace, defense, and medical applications and is a key element in many clean energy technologies. The name cobalt comes from the German word kobold, meaning goblin. It was given this name by medieval miners who believed that troublesome goblins replaced the valuable metals in their ore with a substance that emitted poisonous fumes when smelted. The Swedish chemist Georg Brandt isolated metallic cobalt-the first new metal to be discovered since ancient times-in about 1735 and identified some of its valuable properties.

  16. High-strength beryllium block

    International Nuclear Information System (INIS)

    Pinto, N.P.; Keith, G.H.

    1977-01-01

    Beryllium billets hot isopressed using fine powder of high purity have exceptionally attractive properties; average tensile ultimate, 0.2% offset yield strength and elongation are 590 MPa, 430 MPa and 4.0% respectively. Properties are attributed to the fine grain size (about 4.0 μm average diameter) and the relatively low levels of BeO present as fine, well-dispersed particles. Dynamic properties, e.g., fracture toughness, are similar to those of standard grade, high-purity beryllium. The modulus of beryllium is retained to very high stress levels, and the microyield stress or precision elastic limit is higher than for other grades, including instrument grades. Limited data for billets made from normal-purity fine powders show similar room temperature properties. (author)

  17. Swimbladder on Fish Target Strength

    Directory of Open Access Journals (Sweden)

    Sunardi

    2008-08-01

    Full Text Available This paper discusses of target strength (TS for the Selar boops (Oxeye scad and Megalaspis cordyla (Torpedo scad, the most commercially fish in Malaysia. TS can be determined from in situ measurements and acoustic calculation of fish model. TS value, depth, and position (x-y-z of targeted fish can be viewed from echogram using FQ-80 Analyzer by in situ measurement. X-ray imaged can be deployed to develop the acoustic fish model. The percentage of length and upper surface area for swimbladder to body fish of Selar boops more than Megalaspis cordyla can be measured after X-ray process. The percentage of width and volume of swimbladders to its each body are no significantly difference for both fish. These data of swimbladder physic support the result of in situ measurement which TS of Megalaspis cordyla stronger Selar boops.

  18. Urban e-Mobility - Challenges and potential solutions using the example of the "E3W" concept vehicle

    Science.gov (United States)

    Perterer, M.; Martin, P.; Lochner, H.

    2014-05-01

    Due to the increasing number of people in urban areas, there is a need for affordable individual transportation. Limited space in cities together with the need for a significant reduction of pollution will lead to new mobility concepts in the near future. The aim of these concepts is not replacing the car itself, but to supply an additional personal transportation solution with local zero emission. Therefore, electrical powered vehicle concepts may be used. Due to the limited energy density and high cost of current Li-ion batteries, a significant weight reduction of the vehicle could lead to acceptable range and cost. In order to develop an affordable urban concept, the requirements for this kind of vehicle also have to be adjusted in comparison to conventional cars. This concept, the so called "E3W", combines the advantages of a two-wheeler with those of a four-wheeler, resulting in a lightweight and compact vehicle. This concept accommodates space for two persons with luggage and guarantees a high level of safety including wind and weather protection. The overall measures of this vehicle are smaller than current compact cars and allow therefore better use in cities. In order to fulfill technical and commercial requirements, a load carrying, short fiber reinforced thermoplastic body structure is chosen, combining good weight specific mechanical properties and low production costs. This highly integrated body structure also provides the body cover all in one. Pultruded glass fiber reinforced plastic (GFRP) beams are used as the backbone for the vehicle by carrying the main loads, the front crash structure and the rear swingarm. Finally, two prototypes are built to investigate the driving behavior, proof the concept and the suitability for daily use.

  19. Phosphorylation by PINK1 releases the UBL domain and initializes the conformational opening of the E3 ubiquitin ligase Parkin.

    Directory of Open Access Journals (Sweden)

    Thomas R Caulfield

    2014-11-01

    Full Text Available Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal recessive Parkinson's disease. Both gene products, the Ser/Thr kinase PINK1 and the E3 Ubiquitin ligase Parkin, functionally cooperate in a mitochondrial quality control pathway. Upon stress, PINK1 activates Parkin and enables its translocation to and ubiquitination of damaged mitochondria to facilitate their clearance from the cell. Though PINK1-dependent phosphorylation of Ser65 is an important initial step, the molecular mechanisms underlying the activation of Parkin's enzymatic functions remain unclear. Using molecular modeling, we generated a complete structural model of human Parkin at all atom resolution. At steady state, the Ub ligase is maintained inactive in a closed, auto-inhibited conformation that results from intra-molecular interactions. Evidently, Parkin has to undergo major structural rearrangements in order to unleash its catalytic activity. As a spark, we have modeled PINK1-dependent Ser65 phosphorylation in silico and provide the first molecular dynamics simulation of Parkin conformations along a sequential unfolding pathway that could release its intertwined domains and enable its catalytic activity. We combined free (unbiased molecular dynamics simulation, Monte Carlo algorithms, and minimal-biasing methods with cell-based high content imaging and biochemical assays. Phosphorylation of Ser65 results in widening of a newly defined cleft and dissociation of the regulatory N-terminal UBL domain. This motion propagates through further opening conformations that allow binding of an Ub-loaded E2 co-enzyme. Subsequent spatial reorientation of the catalytic centers of both enzymes might facilitate the transfer of the Ub moiety to charge Parkin. Our structure-function study provides the basis to elucidate regulatory mechanisms and activity of the neuroprotective Parkin. This may open up new avenues for the development of small molecule Parkin

  20. Scientific data products and the data pre-processing subsystem of the Chang'e-3 mission

    International Nuclear Information System (INIS)

    Tan Xu; Liu Jian-Jun; Li Chun-Lai; Feng Jian-Qing; Ren Xin; Wang Fen-Fei; Yan Wei; Zuo Wei; Wang Xiao-Qian; Zhang Zhou-Bin

    2014-01-01

    The Chang'e-3 (CE-3) mission is China's first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives: (1) investigate the morphological features and geological structures at the landing site; (2) integrated in-situ analysis of minerals and chemical compositions; (3) integrated exploration of the structure of the lunar interior; (4) exploration of the lunar-terrestrial space environment, lunar surface environment and acquire Moon-based ultraviolet astronomical observations. The Ground Research and Application System (GRAS) is in charge of data acquisition and pre-processing, management of the payload in orbit, and managing the data products and their applications. The Data Pre-processing Subsystem (DPS) is a part of GRAS. The task of DPS is the pre-processing of raw data from the eight instruments that are part of CE-3, including channel processing, unpacking, package sorting, calibration and correction, identification of geographical location, calculation of probe azimuth angle, probe zenith angle, solar azimuth angle, and solar zenith angle and so on, and conducting quality checks. These processes produce Level 0, Level 1 and Level 2 data. The computing platform of this subsystem is comprised of a high-performance computing cluster, including a real-time subsystem used for processing Level 0 data and a post-time subsystem for generating Level 1 and Level 2 data. This paper describes the CE-3 data pre-processing method, the data pre-processing subsystem, data classification, data validity and data products that are used for scientific studies

  1. Dietary antioxidant capacity and risk of type 2 diabetes in the large prospective E3N-EPIC cohort.

    Science.gov (United States)

    Mancini, Francesca Romana; Affret, Aurélie; Dow, Courtney; Balkau, Beverley; Bonnet, Fabrice; Boutron-Ruault, Marie-Christine; Fagherazzi, Guy

    2018-02-01

    Recent evidence suggests that oxidative stress may contribute to the pathogenesis of type 2 diabetes. The diet, and especially fruit and vegetables, contains a variety of compounds with antioxidant activity, which may have cumulative/synergistic antioxidant effects. The total antioxidant capacity, an index derived from dietary intake, is a single estimate of antioxidant capacity from all dietary antioxidants. The main aim of this study was to investigate the relationship between total antioxidant capacity and risk of type 2 diabetes. Among 64,223 women (mean age 52 ± 7 years) from the French E3N-European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, 1751 women had validated type 2 diabetes during 15 years of follow-up. The total antioxidant capacity was estimated with the ferric ion-reducing antioxidant power (FRAP) method. Adjusted Cox proportional hazards regression models were used to calculate HRs and 95% CIs for the associations between total antioxidant capacity and type 2 diabetes risk, adjusted for potential confounders. In multivariable models, higher levels of total antioxidant capacity were associated with a lower risk of type 2 diabetes. Compared with women in the lowest quintile, women in the third, fourth and fifth quintiles for total antioxidant capacity had HRs of 0.74 (95% CI 0.63, 0.86), 0.70 (95% CI 0.59, 0.83) and 0.73 (95% CI 0.60, 0.89), respectively. The inverse association between total antioxidant capacity and risk of type 2 diabetes was linear up to values of 15 mmol/day, after which the effect reached a plateau. Our findings suggest that the total antioxidant capacity may play an important role in reducing the risk of type 2 diabetes in middle-aged women. More studies are warranted to better understand the biological mechanisms underlying this inverse association.

  2. Tumor characteristics and family history in relation to mammographic density and breast cancer: The French E3N cohort.

    Science.gov (United States)

    Maskarinec, Gertraud; Dartois, Laureen; Delaloge, Suzette; Hopper, John; Clavel-Chapelon, Françoise; Baglietto, Laura

    2017-08-01

    Mammographic density is a known heritable risk factor for breast cancer, but reports how tumor characteristics and family history may modify this association are inconsistent. Dense and total breast areas were assessed using Cumulus™ from pre-diagnostic mammograms for 820 invasive breast cancer cases and 820 matched controls nested within the French E3N cohort study. To allow comparisons across models, percent mammographic density (PMD) was standardized to the distribution of the controls. Odds ratios (OR) and 95% confidence intervals (CI) of breast cancer risk for mammographic density were estimated by conditional logistic regression while adjusting for age and body mass index. Heterogeneity according to tumor characteristic and family history was assessed using stratified analyses. Overall, the OR per 1 SD for PMD was 1.50 (95% CI, 1.33-1.69). No evidence for significant heterogeneity by tumor size, lymph node status, grade, and hormone receptor status (estrogen, progesterone, and HER2) was detected. However, the association of PMD was stronger for women reporting a family history of breast cancer (OR 1SD =2.25; 95% CI, 1.67-3.04) than in women reporting none (OR 1SD =1.41; 95% CI, 1.24-1.60; p heterogeneity =0.002). Similarly, effect modification by FHBC was observed using categories of PMD (p heterogeneity =0.02) with respective ORs of 15.16 (95% CI, 4.23-54.28) vs. 3.14 (95% CI, 1.89-5.22) for ≥50% vs. breast cancer risk with a family history supports the hypothesis of shared genetic factors responsible for familial aggregation of breast cancer and the heritable component of mammographic density. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Inhibition of xanthine oxidase by allopurinol prevents skeletal muscle atrophy: role of p38 MAPKinase and E3 ubiquitin ligases.

    Directory of Open Access Journals (Sweden)

    Frederic Derbre

    Full Text Available Alterations in muscle play an important role in common diseases and conditions. Reactive oxygen species (ROS are generated during hindlimb unloading due, at least in part, to the activation of xanthine oxidase (XO. The major aim of this study was to determine the mechanism by which XO activation causes unloading-induced muscle atrophy in rats, and its possible prevention by allopurinol, a well-known inhibitor of this enzyme. For this purpose we studied one of the main redox sensitive signalling cascades involved in skeletal muscle atrophy i.e. p38 MAPKinase, and the expression of two well known muscle specific E3 ubiquitin ligases involved in proteolysis, the Muscle atrophy F-Box (MAFbx; also known as atrogin-1 and Muscle RING (Really Interesting New Gene Finger-1 (MuRF-1. We found that hindlimb unloading induced a significant increase in XO activity and in the protein expression of the antioxidant enzymes CuZnSOD and Catalase in skeletal muscle. The most relevant new fact reported in this paper is that inhibition of XO with allopurinol, a drug widely used in clinical practice, prevents soleus muscle atrophy by ~20% after hindlimb unloading. This was associated with the inhibition of the p38 MAPK-MAFbx pathway. Our data suggest that XO was involved in the loss of muscle mass via the activation of the p38MAPK-MAFbx pathway in unloaded muscle atrophy. Thus, allopurinol may have clinical benefits to combat skeletal muscle atrophy in bedridden, astronauts, sarcopenic, and cachexic patients.

  4. Preparation, mechanical strengths, and thermal

    Science.gov (United States)

    Inoue, A.; Furukawa, S.; Hagiwara, M.; Masumoto, T.

    1987-05-01

    Ni-based amorphous wires with good bending ductility have been prepared for Ni75Si8B17 and Ni78P12B10 alloys containing 1 to 2 at. pct Al or Zr by melt spinning in rotating water. The enhancement of the wire-formation tendency by the addition of Al has been clarified to be due to the increase in the stability of the melt jet through the formation of a thin A12O3 film on the outer surface. The maximum wire diameter is about 190 to 200 μm for the Ni-Si (or P)-B-Al alloys and increases to about 250 μm for the Ni-Si-B-Al-Cr alloys containing 4 to 6 at. pct Cr. The tensile fracture strength and fracture elongation are 2730 MPa and 2.9 pct for (Ni0.75Si0.08B0.17 99Al1) wire and 2170 MPa and 2.4 pct for (Ni0.78P0.12B0.1)99Al1 wire. These wires exhibit a fatigue limit under dynamic bending strain in air with a relative humidity of 65 pct; this limit is 0.50 pct for a Ni-Si-B-Al wire, which is higher by 0.15 pct than that of a Fe75Si10B15 amorphous wire. Furthermore, the Ni-base wires do not fracture during a 180-deg bending even for a sample annealed at temperatures just below the crystallization temperature, in sharp contrast to high embrittlement tendency for Fe-base amorphous alloys. Thus, the Ni-based amorphous wires have been shown to be an attractive material similar to Fe- and Co-based amorphous wires because of its high static and dynamic strength, high ductility, high stability to thermal embrittlement, and good corrosion resistance.

  5. Association Between Maximal Bench Press Strength and Isometric Handgrip Strength Among Breast Cancer Survivors.

    Science.gov (United States)

    Rogers, Benjamin H; Brown, Justin C; Gater, David R; Schmitz, Kathryn H

    2017-02-01

    To characterize the relationship between 1-repetition maximum (1-RM) bench press strength and isometric handgrip strength among breast cancer survivors. Cross-sectional study. Laboratory. Community-dwelling breast cancer survivors (N=295). Not applicable. 1-RM bench press strength was measured with a barbell and exercise bench. Isometric handgrip strength was measured using an isometric dynamometer, with 3 maximal contractions of the left and right hands. All measures were conducted by staff with training in clinical exercise testing. Among 295 breast cancer survivors, 1-RM bench press strength was 18.2±6.1kg (range, 2.2-43.0kg), and isometric handgrip strength was 23.5±5.8kg (range, 9.0-43.0kg). The strongest correlate of 1-RM bench press strength was the average isometric handgrip strength of both hands (r=.399; Pisometric handgrip strength of both hands overestimated 1-RM bench press strength by 4.7kg (95% limits of agreement, -8.2 to 17.6kg). In a multivariable linear regression model, the average isometric handgrip strength of both hands (β=.31; Pstrength (R 2 =.23). Isometric handgrip strength is a poor surrogate for 1-RM bench press strength among breast cancer survivors. 1-RM bench press strength and isometric handgrip strength quantify distinct components of muscular strength. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  6. Reference Values of Grip Strength, Prevalence of Low Grip Strength, and Factors Affecting Grip Strength Values in Chinese Adults.

    Science.gov (United States)

    Yu, Ruby; Ong, Sherlin; Cheung, Osbert; Leung, Jason; Woo, Jean

    2017-06-01

    The objectives of this study were to update the reference values of grip strength, to estimate the prevalence of low grip strength, and to examine the impact of different aspects of measurement protocol on grip strength values in Chinese adults. A cross-sectional survey of Chinese men (n = 714) and women (n = 4014) aged 18-102 years was undertaken in different community settings in Hong Kong. Grip strength was measured with a digital dynamometer (TKK 5401 Grip-D; Takei, Niigata, Japan). Low grip strength was defined as grip strength 2 standard deviations or more below the mean for young adults. The effects of measurement protocol on grip strength values were examined in a subsample of 45 men and women with repeated measures of grip strength taken with a hydraulic dynamometer (Baseline; Fabrication Enterprises Inc, Irvington, NY), using pair t-tests, intraclass correlation coefficient, and Bland and Altman plots. Grip strength was greater among men than among women (P values than the Baseline hydraulic dynamometer (P values were also observed when the measurement was performed with the elbow extended in a standing position, compared with that with the elbow flexed at 90° in a sitting position, using the same dynamometer (P values of grip strength and estimated the prevalence of low grip strength among Chinese adults spanning a wide age range. These findings might be useful for risk estimation and evaluation of interventions. However, grip strength measurements should be interpreted with caution, as grip strength values can be affected by type of dynamometer used, assessment posture, and elbow position. Copyright © 2017 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

  7. The Importance of Muscular Strength: Training Considerations.

    Science.gov (United States)

    Suchomel, Timothy J; Nimphius, Sophia; Bellon, Christopher R; Stone, Michael H

    2018-04-01

    This review covers underlying physiological characteristics and training considerations that may affect muscular strength including improving maximal force expression and time-limited force expression. Strength is underpinned by a combination of morphological and neural factors including muscle cross-sectional area and architecture, musculotendinous stiffness, motor unit recruitment, rate coding, motor unit synchronization, and neuromuscular inhibition. Although single- and multi-targeted block periodization models may produce the greatest strength-power benefits, concepts within each model must be considered within the limitations of the sport, athletes, and schedules. Bilateral training, eccentric training and accentuated eccentric loading, and variable resistance training may produce the greatest comprehensive strength adaptations. Bodyweight exercise, isolation exercises, plyometric exercise, unilateral exercise, and kettlebell training may be limited in their potential to improve maximal strength but are still relevant to strength development by challenging time-limited force expression and differentially challenging motor demands. Training to failure may not be necessary to improve maximum muscular strength and is likely not necessary for maximum gains in strength. Indeed, programming that combines heavy and light loads may improve strength and underpin other strength-power characteristics. Multiple sets appear to produce superior training benefits compared to single sets; however, an athlete's training status and the dose-response relationship must be considered. While 2- to 5-min interset rest intervals may produce the greatest strength-power benefits, rest interval length may vary based an athlete's training age, fiber type, and genetics. Weaker athletes should focus on developing strength before emphasizing power-type training. Stronger athletes may begin to emphasize power-type training while maintaining/improving their strength. Future research should

  8. Eigenstate Phase Transitions

    Science.gov (United States)

    Zhao, Bo

    Phase transitions are one of the most exciting physical phenomena ever discovered. The understanding of phase transitions has long been of interest. Recently eigenstate phase transitions have been discovered and studied; they are drastically different from traditional thermal phase transitions. In eigenstate phase transitions, a sharp change is exhibited in properties of the many-body eigenstates of the Hamiltonian of a quantum system, but not the thermal equilibrium properties of the same system. In this thesis, we study two different types of eigenstate phase transitions. The first is the eigenstate phase transition within the ferromagnetic phase of an infinite-range spin model. By studying the interplay of the eigenstate thermalization hypothesis and Ising symmetry breaking, we find two eigenstate phase transitions within the ferromagnetic phase: In the lowest-temperature phase the magnetization can macroscopically oscillate by quantum tunneling between up and down. The relaxation of the magnetization is always overdamped in the remainder of the ferromagnetic phase, which is further divided into phases where the system thermally activates itself over the barrier between the up and down states, and where it quantum tunnels. The second is the many-body localization phase transition. The eigenstates on one side of the transition obey the eigenstate thermalization hypothesis; the eigenstates on the other side are many-body localized, and thus thermal equilibrium need not be achieved for an initial state even after evolving for an arbitrary long time. We study this many-body localization phase transition in the strong disorder renormalization group framework. After setting up a set of coarse-graining rules for a general one dimensional chain, we get a simple "toy model'' and obtain an almost purely analytical solution to the infinite-randomness critical fixed point renormalization group equation. We also get an estimate of the correlation length critical exponent nu

  9. Stress, Depression, and Anxiety among Transitioning College Students: The Family as a Protective Factor

    Science.gov (United States)

    Kahn, Jeffrey H.; Kasky-Hernández, Lynda M.; Ambrose, Pamm; French, Sarah

    2017-01-01

    Stress associated with the college transition can bring about depression and anxiety symptoms, but family relationships can reduce the impact of stress. We hypothesized that secure attachment to parents, comfort with talking about stressors, and family support would reduce the strength of the relationships between transition-related stress and…

  10. Anomalies in the coil-stretch transition of flexible polymers

    Science.gov (United States)

    Ghosal, Aishani; Cherayil, Binny J.

    2018-03-01

    The flow-induced coil-stretch transition of high molecular weight polymers has generally been held to be of first order. But evidence of significant slowing down in the rate at which the polymers relax to equilibrium in the vicinity of the transition suggests that the thermodynamic character of the transition may be less clear-cut. The above slowing down effect is actually characteristic of a second-order transition, and it points to the existence of a broad spectrum of conformational states in the transition region, analogous to the existence of fluctuations of all length scales at a critical point. In this paper, using a path integral approach based on a free-draining finitely extensible chain model, we calculate various polymer properties as a function of elongational flow as a way of exploring different statistical mechanical details of the coil-stretch transition. These properties include the molecular weight dependence of the flow-extension curve of the polymer, the distribution of its steady-state end-to-end distances, and the characteristic relaxation time τR of these distances. Among other findings, our calculations indicate that the coil-stretch transition is discontinuous in the N → ∞ limit, that the effective free energy of the chain is unimodal at all values of the flow, becoming broad and flat in the immediate vicinity of the transition, and that the ratio of τR to the Rouse relaxation time increases abruptly at the transition before eventually reaching a plateau value at large flow strengths. These aspects of the coil-stretch transition place it among a larger class of unconventional nominally first-order single chain transitions that include the adsorption transition of surface-tethered polymers and the escape transition of compressed polymers.

  11. Jet formation in cerium metal to examine material strength

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, B. J., E-mail: bjjensen@lanl.gov; Cherne, F. J.; Prime, M. B.; Yeager, J. D.; Ramos, K. J.; Hooks, D. E.; Cooley, J. C.; Dimonte, G. [Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States); Fezzaa, K. [Argonne National Laboratory, Argonne, Illinois 60439 (United States); Iverson, A. J.; Carlson, C. A. [National Security Technologies LLC, Los Alamos, New Mexico 87544 (United States)

    2015-11-21

    Examining the evolution of material properties at extreme conditions advances our understanding of numerous high-pressure phenomena from natural events like meteorite impacts to general solid mechanics and fluid flow behavior. Recent advances in synchrotron diagnostics coupled with dynamic compression platforms have introduced new possibilities for examining in-situ, spatially resolved material response with nanosecond time resolution. In this work, we examined jet formation from a Richtmyer-Meshkov instability in cerium initially shocked into a transient, high-pressure phase, and then released to a low-pressure, higher-temperature state. Cerium's rich phase diagram allows us to study the yield stress following a shock induced solid-solid phase transition. X-ray imaging was used to obtain images of jet formation and evolution with 2–3 μm spatial resolution. From these images, an analytic method was used to estimate the post-shock yield stress, and these results were compared to continuum calculations that incorporated an experimentally validated equation-of-state (EOS) for cerium coupled with a deviatoric strength model. Reasonable agreement was observed between the calculations and the data illustrating the sensitivity of jet formation on the yield stress values. The data and analysis shown here provide insight into material strength during dynamic loading which is expected to aid in the development of strength aware multi-phase EOS required to predict the response of matter at extreme conditions.

  12. Control of inhomogeneous materials strength by method of acoustic emission

    Directory of Open Access Journals (Sweden)

    В. В. Носов

    2017-08-01

    Full Text Available The ambiguous connection between the results of acoustic emission control and the strength of materials makes acoustic-emission diagnosis ineffective and actualizes the problem of strength and metrological heterogeneity. Inhomogeneity is some deviation from a certain norm. The real object is always heterogeneous, homogeneity is an assumption that simplifies the image of the object and the solution of the tasks associated with it. The need to consider heterogeneity is due to the need to clarify a particular task and is a transition to a more complex level of research. Accounting for heterogeneity requires the definition of its type, criterion and method of evaluation. The type of heterogeneity depends on the problem being solved and should be related to the property that determines the function of the real object, the criterion should be informative, and the way of its evaluation is non-destructive. The complexity of predicting the behavior of heterogeneous materials necessitates the modeling of the destructive process that determines the operability, the formulation of the inhomogeneity criterion, the interpretation of the Kaiser effect, as showing inhomogeneity of the phenomenon of non-reproduction of acoustic emission (AE activity upon repeated loading of the examined object.The article gives an example of modeling strength and metrological heterogeneity, analyzes and estimates the informative effect of the Kaiser effect on the danger degree of state of diagnosed object from the positions of the micromechanical model of time dependencies of AE parameters recorded during loading of structural materials and technical objects.

  13. Transition and Electron Impact Excitation Collision Rates for O III

    Science.gov (United States)

    Tayal, S. S.; Zatsarinny, O.

    2017-12-01

    Transition probabilities, electron excitation collision strengths, and rate coefficients for a large number of O III lines over a broad wavelength range, from the infrared to ultraviolet, have been reported. The collision strengths have been calculated in the close-coupling approximation using the B-spline Breit-Pauli R-matrix method. The multiconfiguration Hartree-Fock method in combination with B-spline expansions is employed for an accurate representation of the target wave functions. The close-coupling expansion contains 202 O2+ fine-structure levels of the 2{s}22{p}2,2s2{p}3, 2{p}4,2{s}22p3s,3p,3d, 4s,4p,4d,4f,5s, and 2s2{p}33s,3p,3d configurations. The effective collision strengths are obtained by averaging electron excitation collision strengths over a Maxwellian distribution of velocities at electron temperatures ranging from 100 to 100,000 K. The calculated effective collision strengths have been reported for the 20,302 transitions between all 202 fine-structure levels. There is an overall good agreement with the recent R-matrix calculations by Storey et al. for the transitions between all levels of the ground 2{s}22{p}2 configuration, but significant discrepancies have been found with Palay et al. for transitions to the 2{s}22{p}2 1 S 0 level. Line intensity ratios between the optical lines arising from the 2{s}22{p}2{}3{P}{0,1,2} - 1 D 2 transitions have been compared with other calculations and observations from the photoionized gaseous nebulae, and good agreement is found. The present calculations provide the most complete and accurate data sets, which should allow a more detailed treatment of the available measured spectra from different ground and space observatories.

  14. Youth and administrator perspectives on transition in Kentucky's state agency schools.

    Science.gov (United States)

    Marshall, Amy; Powell, Norman; Pierce, Doris; Nolan, Ronnie; Fehringer, Elaine

    2012-01-01

    Students, a large percentage with disabilities, are at high risk for poor post-secondary outcomes in state agency education programs. This mixed-methods study describes the understandings of student transitions in state agency education programs from the perspectives of youth and administrators. Results indicated that: transition is more narrowly defined within alternative education programs; key strengths of transition practice are present in nontraditional schools; and the coordination barriers within this fluid inter-agency transition system are most apparent in students' frequent inter-setting transitions between nontraditional and home schools.

  15. Beta decay and strength distributions

    International Nuclear Information System (INIS)

    Hardy, J.C.

    1980-01-01

    With the increasing accessibility of nuclei far from stability, experimenters find themselves faced more and more often with complex β-decay schemes: nuclei with over 5 MeV of β-decay energy, exhibiting hundreds and perhaps thousands of transitions. A detailed level-by-level exposition of such schemes - for example, by studying β-delayed γ-rays - is at best prohibitively time consuming, and at worst actually impossible with current techniques. Furthermore, even if reliable schemes are obtained experimentally, their confrontation with theory is severely limited by the absence of theories sufficiently complete to account for such complex spectra. At best, it is the details of the first few excited states and the general features of the rest that are useful for comparison. From both points of view, experimental and theoretical, there is strong motivation to find a broader perspective, emphasizing these general features without being overwhelmed by a proliferation of detail

  16. Traditional versus functional strength training: Effects on muscle strength and power in the elderly

    OpenAIRE

    Seiler, Hilde Lohne; Torstveit, Monica Klungland; Anderssen, Sigmund A.

    2013-01-01

    Published versiom of an article in the journal:Journal of Aging and Physical Activity. Also available from Human Kinetics: http://http://journals.humankinetics.com/japa-back-issues/japa-volume-21-issue-1-january/traditional-versus-functional-strength-training-effects-on-muscle-strength-and-power-in-the-elderly The aim was to determine whether strength training with machines vs. functional strength training at 80% of one-repetition maximum improves muscle strength and power among the elderl...

  17. Transitivity of Preferences

    Science.gov (United States)

    Regenwetter, Michel; Dana, Jason; Davis-Stober, Clintin P.

    2011-01-01

    Transitivity of preferences is a fundamental principle shared by most major contemporary rational, prescriptive, and descriptive models of decision making. To have transitive preferences, a person, group, or society that prefers choice option "x" to "y" and "y" to "z" must prefer "x" to…

  18. Alaska Community Transit

    Science.gov (United States)

    Grant Information Human Services Funding 5310 5316 (Repealed) 5317 (Repealed) Alaska Mental Health Trust Department of Transportation & Public Facilities/ Alaska Community Transit Search DOT&PF State of Alaska Photo banner DOT&PF> Program Development > Alaska Community Transit Home About Us

  19. Distance-transitive graphs

    NARCIS (Netherlands)

    Cohen, A.M.; Beineke, L.W.; Wilson, R.J.; Cameron, P.J.

    2004-01-01

    In this chapter we investigate the classification of distance-transitive graphs: these are graphs whose automorphism groups are transitive on each of the sets of pairs of vertices at distance i, for i = 0, 1,.... We provide an introduction into the field. By use of the classification of finite

  20. Towards Transition Theory

    NARCIS (Netherlands)

    J. de Haan (Hans)

    2010-01-01

    textabstractThis thesis is a treatise on a theory for societal transitions: pillar theory. Societal transitions are complex processes taking place in complex systems, large-scale, long-term processes in which societal systems radically change the way they are composed and function. Since we all are