WorldWideScience

Sample records for e region

  1. Son huasteco e identidad regional

    Directory of Open Access Journals (Sweden)

    Rosa María Bonilla Burgos

    2013-01-01

    Full Text Available La población de la región Huasteca es partícipe de manifestaciones musicales en diferentes ámbitos, lo cual permite reconocer que entre todos los géneros utilizados destaca el son huasteco y su correspondiente bailable llamado huapango. Dichas expresiones musicales se impregnan de los ambientes tanto físico como social que viven constantemente. Es a través de las letras de los sones huastecos que se desarrolla el mecanismo para reflejar el mundo natural que perciben, y los acontecimientos que les suceden, cobrando una importancia que deriva en una identificación que trasciende. Conciben su entorno y lo refieren con sentido de pertenencia-apropiación, que les permite recrear su vida y fundirse en una identificación cultural a la que se le llamará "identidad regional". La relevancia de considerar una expresión musical de estas características radica en que se preserva y enriquece constantemente unificando un área de México que no necesariamente corresponde a límites políticos establecidos en las diferentes etapas históricas.

  2. Celso Furtado e o desenvolvimento regional

    Directory of Open Access Journals (Sweden)

    Clélio Campolina Diniz

    2011-01-01

    Full Text Available O presente texto visa analisar as contribuições de Celso Furtado para a interpretação dos determinantes das desigualdades regionais e para a formulação de políticas de desenvolvimento para as regiões menos desenvolvidas. Toma como pano de fundo os antecedentes teóricos e as principais experiências mundiais de políticas de desenvolvimento regional, que serviram de referência para Celso Furtado. Mostra a originalidade de Furtado ao articular as questões de desigualdades regionais à natureza das estruturas subdesenvolvidas. Mostra os fundamentos teóricos e empíricos na análise sobre a questão nordestina, as diretrizes para a atuação da futura SUDENE, as pressões políticas e as insuficiências na condução da política de desenvolvimento para o Nordeste. Por fim, mostra a atualidade de Furtado, seja nas formulações anteriores à criação da SUDENE como nos desenvolvimentos teóricos posteriores. Nesses, Furtado supera a noção de região e passa a tratar de estruturas espaciais; introduz o papel central dos nódulos urbanos, de suas hierarquias e articulações, ou seja ,o papel da rede urbana no comando e estruturação do território; do papel central da tecnologia e dos processos de inovação e; por fim, da necessidade de um esforço interdisciplinar, tanto para o entendimento dos problemas regionais quanto para a formulação de políticas e de sua implementação.

  3. On E-Capacity Region of the Wiretap Channel

    Directory of Open Access Journals (Sweden)

    Nasrin Afshar

    2013-09-01

    Full Text Available We study the E-capacity region of the wiretap channel. A random coding bound for E-capacity region is obtained. When E tends to 0, the proposed inner bound converges to the capacity region obtained by Csiszár and Körner

  4. Celso Furtado e o desenvolvimento regional

    Directory of Open Access Journals (Sweden)

    Clélio Campolina Diniz

    2009-08-01

    Full Text Available This text analyzes the contributions by Celso Furtado to interpreting the determinants of regional inequalities and to the formulation of development policies for less developed regions. It uses a backdrop the theoretical antecedents and principal global experiences of regional development policies, which served as a reference for Celso Furtado. It shows Furtado's originality when he linked questions of regional inequality with the nature of underdeveloped structures. It shows the theoretical and empirical foundations in the analysis of the Northeast question, guidelines for the future SUDENE, political pressures and the insufficiencies in the way development policies for the Northeast are carried out. Finally, it shows how Furtado's positions are still relevant, whether in the formulations prior to the creation of SUDENE or in the later theoretical developments. In these, Furtado overcomes the notion of region and begins to examine spatial structures; he introduces the central role of urban nodes, of their hierarchies and articulations; in other words, the role of the urban network in the command and structuring of the territory; of the central role of technology and innovation processes, and finally, of the need for an interdisciplinary effort for both understanding regional problems as well as for the formulation of policies and their implementation.

  5. Medical e-commerce for regional Australia.

    Science.gov (United States)

    Kumar, D K; Mikelaitis, P

    2001-12-01

    The residents of rural and regional Australia have less access to health care services than in capital cities. There is a reluctance of General Practitioners to practice in the country. New information technology and government initiatives are now addressing this problem. High bandwidth videoconferencing is now being routinely used to provide psychiatric consultations to areas without this service. But this (like many other implementations of telecommunication technologies to health) has resulted in loss of revenue to regional Australia while benefiting capital cities. Thus, the current implementation of telecommunication technology to health has resulted in loss of revenue of the regions while increasing the bias towards the cities. Further, the system is not economically viable and requires the Government to inject funds for the smooth operation of the system. This paper proposes the use of telecommunication technology for enabling the communities of regional Australia to access health facilities via physical and virtual clinics. The proposed technique is self supporting and is based in the country with the intent to prevent the drain of resources from regional Australia. The technique attempts to eradicate the problem at the root level by providing a business opportunity that is based in and to cater for the needs of the remote communities. The proposed system would provide health services by physical and virtual clinics and while serving the communities would be profit centres- and thus attracting doctors and other resources to the remote communities.

  6. eBusiness Maturity and Regional Development

    Directory of Open Access Journals (Sweden)

    Beynon-Davies, P.

    2007-01-01

    Full Text Available This paper describes the experience of a major research centre supporting knowledge transfer in the area of eCommerce to SMEs. It debates with issues surrounding the integration of academic research with practical support to the SME community. For this purpose the use of an eBusiness framework as a platform for eBusiness maturity assessment is proposed. These devices are seen as key to the work of research centres such as ours in addressing the future challenges for smeeBusiness.

  7. Intolerancia e integración regional

    Directory of Open Access Journals (Sweden)

    Alfredo Falero Cirigliano

    2004-01-01

    Full Text Available Desde una perspectiva sociológica, el artículo aborda la idea de intolerancia específicamente en lo referente a actitudes y prácticas xenofóbicas y las enmarca dentro del concepto de construcción de subjetividad social. En tal sentido, se analiza la idea de que esa no inclusión del “otro” resulta funcional y prospera en un contexto en el que los proyectos de integración regional apuntan a la libre movilidad del capital, pero con un control geográfico de la fuerza de trabajo. Teniendo en cuenta algunos ejemplos, se considera asimismo que cualquier proyecto alternativo requiere la idea de ponderar adecuadamente el papel que tienen las organizaciones de la sociedad civil y el Estado para construir otra subjetividad social incluyente.

  8. Governo del territorio e grandi trasformazioni nella regione urbana milanese

    Directory of Open Access Journals (Sweden)

    Fulvia Pinto

    2010-02-01

    Full Text Available  Lo studio analizza le grandi trasformazioni in atto nella “regione urbana” milanese, esaminando gli strumenti, le strategie e le politiche seguite. Per “regione urbana” si intende un territorio che non fa riferimento a relazioni gerarchiche di tipo centro-periferico, bensì determina relazioni multi direzionali, a differenza dell’area metropolitana che viene definita in base a relazioni di dipendenza (economica, sociale, funzionale, ecc. di agglomerati esterni rispetto ad un capoluogo. La regione urbana milanese è uno dei poli economici e produttivi più attivi a livello nazionale ed europeo, tuttavia tale territorio è caratterizzato da una ridotta qualità urbana e ambientale e da fenomeni di polarizzazione e di frammentazione sociale in aumento, che hanno ripercussioni negative sulle prospettive di sviluppo dell'area. I più recenti strumenti di pianificazione dell’area milanese fanno riferimento alla coesione territoriale, cercando di disegnare una nuova struttura per il territorio frammentato e diffuso, consolidando il policentrismo della regione urbana, favorendo il riconoscimento di aggregazioni intermedie, al cui interno ricercare integrazione del sistema dei servizi, identità e appartenenze di area. Per attivare una politica di riqualificazione a livello urbano e territoriale, risulta fondamentale seguire forme di coordinamento tra i vari livelli di pianificazione. Particolare attenzione viene posta al problema della mobilità che richiede strategie particolari non solo del traffico quale effetto indotto, ma anche delle cause che lo producono, con riferimento specifico alla distribuzione sul territorio delle diverse attività, ad un corretto equilibrio tra insediamenti residenziali, produttivi e terziari. È necessario, dunque, individuare strumenti e procedure, capaci di perseguire un equilibrio dinamico tra i flussi attratti dalle attività insediate e i flussi “sostenibili” dalle infrastrutture di trasporto

  9. Observation of isotropic electron temperature in the turbulent E region

    Directory of Open Access Journals (Sweden)

    S. Saito

    Full Text Available Using EISCAT radar data, we find that electrons are strongly heated in the magnetic field-line direction during high electric field events. The remote site data show that the electron temperature increases in almost the same way in the field-perpendicular direction; electron heating by E region plasma turbulence is isotropic. We discuss the implications of our observation for the "plasmon"-electron as well as the wave Joule heating models of the anomalous electron heating in the E region.

    Key words. Ionosphere (auroral ionosphere; plasma temperature and density; plasma waves and instabilities

  10. SEE-GRID eInfrastructure for Regional eScience

    Science.gov (United States)

    Prnjat, Ognjen; Balaz, Antun; Vudragovic, Dusan; Liabotis, Ioannis; Sener, Cevat; Marovic, Branko; Kozlovszky, Miklos; Neagu, Gabriel

    In the past 6 years, a number of targeted initiatives, funded by the European Commission via its information society and RTD programmes and Greek infrastructure development actions, have articulated a successful regional development actions in South East Europe that can be used as a role model for other international developments. The SEEREN (South-East European Research and Education Networking initiative) project, through its two phases, established the SEE segment of the pan-European G ´EANT network and successfully connected the research and scientific communities in the region. Currently, the SEE-LIGHT project is working towards establishing a dark-fiber backbone that will interconnect most national Research and Education networks in the region. On the distributed computing and storage provisioning i.e. Grid plane, the SEE-GRID (South-East European GRID e-Infrastructure Development) project, similarly through its two phases, has established a strong human network in the area of scientific computing and has set up a powerful regional Grid infrastructure, and attracted a number of applications from different fields from countries throughout the South-East Europe. The current SEEGRID-SCI project, ending in April 2010, empowers the regional user communities from fields of meteorology, seismology and environmental protection in common use and sharing of the regional e-Infrastructure. Current technical initiatives in formulation are focusing on a set of coordinated actions in the area of HPC and application fields making use of HPC initiatives. Finally, the current SEERA-EI project brings together policy makers - programme managers from 10 countries in the region. The project aims to establish a communication platform between programme managers, pave the way towards common e-Infrastructure strategy and vision, and implement concrete actions for common funding of electronic infrastructures on the regional level. The regional vision on establishing an e

  11. Synchrotron Radiation in eRHIC Interaction Region

    CERN Document Server

    Beebe-Wang, Joanne; Montag, Christoph; Rondeau, Daniel J; Surrow, Bernd

    2005-01-01

    The eRHIC currently under study at BNL consists of an electron storage ring added to the existing RHIC complex. The interaction region of this facility has to provide the required low-beta focusing while accommodating the synchrotron radiation generated by beam separation close to the interaction point. In the current design, the synchrotron radiation caused by 10GeV electrons bent by low-beta triplet magnets will be guided through the interaction region and dumped 5m downstream. However, it is unavoidable to stop a fraction of the photons at the septum where the electron and ion vacuum system are separated. In order to protect the septum and minimize the backward scattering of the synchrotron radiation, an absorber and collimation system will be employed. In this paper, we first present the overview of the current design of the eRHIC interaction region with special emphasis on the synchrotron radiation. Then the initial design of the absorber and collimation system, including their geometrical and physical p...

  12. Energetics and structure of the lower E region associated with sporadic E layer

    Directory of Open Access Journals (Sweden)

    K.-I. Oyama

    2008-09-01

    Full Text Available The electron temperature (Te, electron density (Ne, and two components of the electric field were measured from the height of 90 km to 150 km by one of the sounding rockets launched during the SEEK-2 campaign. The rocket went through sporadic E layer (Es at the height of 102 km–109 km during ascent and 99 km–108 km during decent, respectively. The energy density of thermal electrons calculated from Ne and Te shows the broad maximum in the height range of 100–110 km, and it decreases towards the lower and higher altitudes, which implies that a heat source exists in the height region of 100 km–110 km. A 3-D picture of Es, that was drawn by using Te, Ne, and the electric field data, corresponded to the computer simulation; the main structure of Es is projected to a higher altitude along the magnetic line of force, thus producing irregular structures of Te, Ne and electric field in higher altitude.

  13. E-region echo characteristics governed by auroral arc electrodynamics

    Directory of Open Access Journals (Sweden)

    S. E. Milan

    Full Text Available Observations of a pair of auroral arc features by two imagers, one ground- and one space-based, allows the associated field-aligned current (FAC and electric field structure to be inferred. Simultaneous observations of HF radar echoes provide an insight into the irregularity-generating mechanisms. This is especially interesting for the E-region echoes observed, which form the focus of our analysis, and from which several conclusions can be drawn, summarized as follows. Latitudinal variations in echo characteristics are governed by the FAC and electric field background. Particularly sharp boundaries are found at the edges of auroral arcs. Within regions of auroral luminosity, echoes have Doppler shifts below the ion-acoustic speed and are proportional to the electric field, suggesting scatter from gradient drift waves. Regions of downward FAC are associated with mixed high and low Doppler shift echoes. The high Doppler shift component is greatly in excess of the ion-acoustic speed, but seems to be commensurate with the driving electric field. The low Doppler shift component appears to be much depressed below expectations.

    Key words. Ionosphere (ionospheric irregularities; electric fields and currents

  14. Turismo e desenvolvimento regional: atrativos turísticos

    Directory of Open Access Journals (Sweden)

    Moacir José Santos

    2015-12-01

    Full Text Available O presente artigo tem como objetivo apresentar caracterizar a Microrregião de Bananal a partir da identificação dos seus atrativos na Estrada Real - Caminho Novo da Piedade, nos municípios de Areias e Bananal dentro do território denominado como Vale Histórico, para apontar ações realizadas ou que possam vir a ser para o desenvolvimento daquele local, contemplando essencialmente a preservação de elementos históricos compatibilizados com o meio-ambiente urbano e a atividade turística contemporânea. Após a decadência do ciclo do café no Vale do Paraíba Paulista, espaços como fazendas, caminhos coloniais e municípios se voltam para a prática da atividade turística, explorando sua história, sua cultura, suas edificações, e seus recursos naturais e culturais como uma alternativa no processo econômico da região. Diante das afinidades históricas, culturais e geográficas encontradas entre os municípios de Areias e Bananal optou-se por destacá-los na identificação dos atrativos turísticos do Vale Histórico na Estrada Real - Caminho Novo da Piedade. A pesquisa caracterizou-se como exploratória descritiva com abordagem qualitativa, com base na qual se pretende estudar dados socioeconômicos além de identificar seus atrativos turísticos, propondo analisar a economia na região delimitada. Os resultados indicam ausência de uma política pública consistente para o desenvolvimento turístico em relação ao potencial apresentado na região. Conclui-se que somente a elaboração e efetivação de uma política pública dedicada a promover um circuito turístico integrado na microrregião produzirão benefícios para a geração de emprego e renda e, simultaneamente, a preservação do patrimônio histórico.  PALAVRAS-CHAVE: Desenvolvimento regional; turismo; microrregião de Bananal.   ABSTRACT This article aims to present characterize Bananal from the identification of its attractions in Estrada Real - Caminho Novo da

  15. Region Evolution eXplorer - A tool for discovering evolution trends in ontology regions.

    Science.gov (United States)

    Christen, Victor; Hartung, Michael; Groß, Anika

    2015-01-01

    A large number of life science ontologies has been developed to support different application scenarios such as gene annotation or functional analysis. The continuous accumulation of new insights and knowledge affects specific portions in ontologies and thus leads to their adaptation. Therefore, it is valuable to study which ontology parts have been extensively modified or remained unchanged. Users can monitor the evolution of an ontology to improve its further development or apply the knowledge in their applications. Here we present REX (Region Evolution eXplorer) a web-based system for exploring the evolution of ontology parts (regions). REX provides an analysis platform for currently about 1,000 versions of 16 well-known life science ontologies. Interactive workflows allow an explorative analysis of changing ontology regions and can be used to study evolution trends for long-term periods. REX is a web application providing an interactive and user-friendly interface to identify (un)stable regions in large life science ontologies. It is available at http://www.izbi.de/rex.

  16. Hepatitis E Virus Infection: A Neglected Problem in Our Region

    Directory of Open Access Journals (Sweden)

    Seyed Moayed Alavian

    2007-09-01

    Full Text Available Hepatitis E is one of the most important infectious problems in developing countries as other oral-fecal transmitted infections(1, 2. Hepatitis E virus (HEV infection is enterically transmitted and widely spread in many tropical and subtropical countries. Hepatitis E is an important public health concern in many developing countries of Asia and Africa where environmental sanitation facilities are poor (3. Large outbreaks of hepatitis E were observed in, India, Pakistan, Nepal, Myanmar, China (4, in East Africa which affecting the Ethiopian refugees in Somalia and Sudan (5, and Central Asia (6. Usually hepatitis E occurs in localities with a high population density, lowlands, and valley areas. The incidence and prevalence rate of HEV infection is underestimated due to unavailability of laboratory services in endemic territories. It is believed that in India at least one-half of acute sporadic viral hepatitis cases in adults are etiologically associated with HEV (7. In endemic areas general sanitation is poor, so HEV spreads through contaminated water sources frequently and non-human HEV reservoirs are very probable. Under natural conditions, fecally contaminated drinking water seems to be the principle vehicle of HEV transmission. Almost all large outbreaks or epidemics of hepatitis E were caused by the consumption of contaminated water. In particular, epidemic situations often arise during the rainy seasons or floods when sewage waters gain access to open water reservoirs (8. Food-borne outbreaks occur less frequently and usually involve fewer people. Contact or person-to-person transmission is known to exist, particularly during or after big epidemics, but occurs at a lower rate when compared with other enteric viral infections (e.g. hepatitis A (9. In non-endemic areas and in industrialized countries, travelers to endemic regions are at major risk of HEV infection (imported cases, but sporadic cases of acute hepatitis E without an implicated

  17. ENERGIA SOSTENIBILE: PIANIFICAZIONE STRATEGICA E PROGRAMMI ECONOMICI NELLA REGIONE LAZIO

    Directory of Open Access Journals (Sweden)

    Leonide Tocchi

    2017-06-01

    Full Text Available The new energy and regulatory scenarios on European and Italian level require a review of the regional energy strategies. Transitioning the global economy from fossil fuels to renewable energy sources has been identified as a key strategy for mitigating climate change. Energy sector transformation needs smart policies. The Lazio region is drawing up a new strategy for sustainable energy that aims to define the necessary conditions for development of a regional energy system increasingly turned to the use of renewable sources and efficient energy use as a means for greater environmental protection, in particular for the purpose of reduction of greenhouse gases (GHG. The strategy aims to facilitate the transition to a low carbon economy by increasing energy production from renewable sources, fostering a green economic recovery and the creation of green jobs in Lazio Region.

  18. Morphology and phenomenology of the high-latitude E and F regions

    Science.gov (United States)

    Hunsucker, R. D.

    1979-01-01

    Results obtained at high latitude observatories on the behavior of E and F region ionization are presented including a bibliography. Behavior of E and F region ionization during day and night for quiet and disturbed conditions in the auroral and polar regions is described. Daily, seasonal and sunspot variations are also outlined.

  19. REGIONES E INFRAESTRUCTURA EN LA INTEGRACIÓN SURAMERICANA

    OpenAIRE

    Vieira Posada,Edgar

    2013-01-01

    El tema del desarrollo territorial y regional ha vuelto a adquirir importancia en el contexto de la globalización contemporánea, donde elementos conceptuales de aglomeración en entornos de competencia imperfecta y de nuevas teorizaciones como la nueva geografía económica, se unen a un trabajo intenso de desarrollo de regiones en Europa y en otras latitudes, mientras Suramérica ha quedado rezagada por el poco avance en estos temas en los procesos de integración de la Comunidad Andina y del Mer...

  20. Banche, territorio e sviluppo (Banks, Regions and Development

    Directory of Open Access Journals (Sweden)

    Pietro Alessandrini

    2012-04-01

    Full Text Available From the 1980s onwards the banking sectors in all the industrialised countries have been experiencing intense restructuring, aggregation and consolidation, radically changing their ownership structures and geography. Whatever the reasons behind such restructuring processes, the globalisation of the credit markets, the consolidation of banking structures, the removal of barriers to the free location of banks and their penetration of peripheral markets pose two main questions. Will integration of the banking systems lead to a narrowing or a widening of the development gap between regions? What relations will there be between financial centres and the periphery, and how will financial labour be divided between national (international banks and local (regional banks? The aim of this paper is to address such questions in the light of recent developments in the theoretical and empirical literature on financial integration.  JEL Codes: G21, G28, G34Keywords: Bank, Banking, Credit, Globalization, Restructuring

  1. Banche, territorio e sviluppo (Banks, Regions and Development

    Directory of Open Access Journals (Sweden)

    Pietro Alessandrini

    2003-03-01

    Full Text Available From the 1980s onwards the banking sectors in all the industrialised countries have been experiencing intense restructuring, aggregation and consolidation, radically changing their ownership structures and geography. Whatever the reasons behind such restructuring processes, the globalisation of the credit markets, the consolidation of banking structures, the removal of barriers to the free location of banks and their penetration of peripheral markets pose two main questions. Will integration of the banking systems lead to a narrowing or a widening of the development gap between regions? What relations will there be between financial centres and the periphery, and how will financial labour be divided between national (international banks and local (regional banks? The aim of this paper is to address such questions in the light of recent developments in the theoretical and empirical literature on financial integration.

  2. Role of E-commerce in Economic Development of Russian Regions

    Directory of Open Access Journals (Sweden)

    Makhosheva SA

    2015-11-01

    Full Text Available This article assesses the potential opportunities for development of e-commerce in Russian regions, as exemplified by the Far-Eastern federal district. As opined by the authors, in the current economic instability situation, Internet trade provides extra markets and allows to maintain financial stability of regional entities, possibly contributing extra to regional budgets. The authors give a general characteristic of the economy and regional retail and find the factors negatively effecting the development of the Far-Eastern e-commerce. Those, first of all, include underdevelopment of payment services, lacks of legal regulation of e-commerce sector, infrastructure issues of the regional development.

  3. Regional Consortia for E-Resources: A Case Study of Deals in the South China Region

    Science.gov (United States)

    Chunrong, Luo; Jingfen, Wang; Zhinong, Zhou

    2010-01-01

    Purpose: The purpose of this paper is to analyse the current situation and the social and economic benefits from the consortia acquisitions of electronic resources by the China Academic Library and Information System (CALIS) South China Regional Centre and to recommend improvements for consortia acquisitions. Design/methodology/approach: Analyses…

  4. Interfaces entre plano regional de desenvolvimento e planos plurianuais municipais: o caso do Corede Noroeste Colonial

    OpenAIRE

    Alves, Caroline Maria Toebe

    2015-01-01

    Este trabalho apresenta o estudo de como ocorre o processo de planejamento governa-mental municipal de médio prazo e quais as interfaces do plano de desenvolvimento regional com os planos plurianuais dos municípios do Corede Noroeste Colonial. Para tanto, buscou-se na literatura os conceitos de Desenvolvimento e Planejamento Regional e a importância estra-tégica de um Plano de Desenvolvimento Regional e da Participação. Depois foram elucidados os Instrumentos de Gestão no Setor Público: PPA, ...

  5. Daytime zonal drifts in the ionospheric E and 150 km regions estimated using EAR observations

    Science.gov (United States)

    Peddapati, PavanChaitanya; Otsuka, Yuichi; Yamamoto, Mamoru; Yokoyama, Tatsuhiro; Patra, Amit

    2016-07-01

    The Equatorial Atmosphere Radar (EAR), located at Kototabang (0.2o S, 100.32o E, mag. lat. 10.36o S), Indonesia, is capable of detecting both E region and 150 km echoes during daytime. We have conducted multi-beam observations using the EAR during daytime covering all seasons to study seasonal variations of these echoes and their dynamics. Given the facts that drifts at the 150 km region are governed primarily by electric field, drifts at the E region are governed by both electric field and neutral wind, simultaneous observations of drifts in both E and 150 km regions would help understand their variations. In this paper we present local time and seasonal variations of zonal drifts in the E and 150 km regions estimated using multi-beam observations. Zonal drifts (positive eastward) in the E and 150 km regions are found to be in the range of -10 to -60 m/s and -40 to 80 m/s, respectively. In the E region, zonal drifts show height reversal and temporal variations having tidal signature and noticeable seasonal variations. Zonal drifts in the 150 km region also show noticeable height and seasonal variations. These results are compared with model drifts and evaluated in terms of electric field and neutral wind.

  6. e+e- collisions in the multi-TeV region

    Energy Technology Data Exchange (ETDEWEB)

    Ellis, J.

    1983-05-01

    A leading role in the elucidation of the Standard Model during the last few years has been played by e+e- colliding beam experiments. The e+e- discoveries have been made possible by the cleanliness of the experimental conditions and the ability to tune the centre-of-mass energy with precision to the desired value, thus avoiding less interesting background events. We expect history to repeat itself in the next step of elucidating physics beyond the Standard Model. Just as past e+e- machines such as SPEAR, DORIS and CESR have uncovered physics inaccessible to hadron-hadron collisions with a centre-of-mass energy several times higher, so we feel that future e+e- colliders will provide information that could not be duplicated by hadron colliders with much larger centre-of-mass energies. There is a general consensus that the next interesting energy range is likely to be in the TeV range. It is in this energy range that whatever physics provides and stabilizes the masses of the intermediate vector bosons must be revealed. Unravelling this mass generation mechanism takes us beyond the gauge principle of the Standard Model which has been so triumphantly vindicated in recent months. Therefore we discuss here the capabilities and attributes of an e+e- collider with at least 1 TeV energy per beam. We believe that by enabling an important new energy domain to be explored in detail, such an e+e- collider provides physics opportunities which cannot be paralled by hadron-hadron colliding rings with centre-of-mass energies several times higher. (WHK)

  7. Planejamento regional e a questão ambiental em Santa Catarina: caminhos e descaminhos

    OpenAIRE

    Luciana Butzke; Ivo Marcos Theis

    2007-01-01

    This article aims to examine the regional and urban planning process in Santa Catarina taking as the theoretical and normative reference the “planning for sustainable territorial development” approach. Ithas been assumed that the Santa Catarina’s experience of planning has characteristics of conventional planning: it puts the economic dimension and the short term in the foreground, it is centralized, and it addresses the regional and urban inequalities, as well as the environmental issues, in...

  8. Neutral wind acceleration in the polar lower E-region during an intense electric-field

    Science.gov (United States)

    Tsuda, Takuo T.; Buchert, Stephan C.; Nozawa, Satonori; Oyama, Shin-ichiro; Ogawa, Yasunobu; Fujii, Ryoichi

    2016-04-01

    The Joule heating and ion drag effects are considered as important factors in the neutral wind dynamics in the polar E-region. However, quantitative evaluations for these effects are insufficient for correct understanding, particularly, in the lower E-region (100-110 km heights) where the anomalous heating effect, related with the electron Pedersen currents, can occur during the intense electric field. In the present study, using EISCAT Svalbard radar data, we have investigated, for the first time, the normal and anomalous heating effects to the neutral wind acceleration in the lower E-region.

  9. E-WASTE MANAGEMENT IN MUMBAI METROPOLITAN REGION: CONSTRAINTS AND OPPORTUNITIES

    OpenAIRE

    Rode, Sanjay

    2012-01-01

    The use of electronic goods is growing fast because of innovations, low price and easy to use facilities. Due to higher income, standard of living and professional requirement, people are replacing the electronic goods very fast. Mumbai Municipal Corporation is generating high e-waste in Mumbai Metropolitan Region. In Thane district, Thane Municipal Corporation generates high e-waste but Ulhasnagar Municipal Corporation generates low e-waste. E-waste generation is depending on population, hea...

  10. WHO EMRO's approach for supporting e-health in the Eastern Mediterranean Region.

    Science.gov (United States)

    N, Al-Shorbaji

    2006-01-01

    "E-health" is a generic term covering the use of computer and communication applications and technologies in health and medical care. This paper outlines WHO's dynamic and diversified approach for supporting e-health by the Regional Office of the Eastern Mediterranean. This includes: policy-setting; human resources development; planning, monitoring and evaluation; networking and communication; infrastructure development; consulting services; electronic publishing; systems development; e-learning; telemedicine; and online library services and support to HINARI It also reviews some of the impediments towards development of e-health in the Region.

  11. Transcriptional activation by the E1A regions of adenovirus types 40 and 41

    NARCIS (Netherlands)

    Loon, A.E. van; Gilardi, P.; Perricaudet, M.; Rozijn, Th. H.; Sussenbach, J.S.

    1987-01-01

    In order to establish whether the poor growth of the two fastidious adenoviruses types 40 and 41 (Ad40 and Ad41) in HeLa cells is due to a reduced trans-activation by the early region to (E1A), we have determined the trans-activating effect of this region on the expression of the chloramphenicol ace

  12. A New 50-MHz VHF Digital Bistatic Radar for E-region Space Physics Research

    Science.gov (United States)

    Hussey, G. C.; Huyghebaert, D. R.; St-Maurice, J. P.; McWilliams, K. A.

    2015-12-01

    A new fully digital bistatic 50-MHz VHF radar is currently being developed by the radar group in the Institute of Space and Atmospheric Studies (ISAS) at the University of Saskatchewan. This paper presents the scientific motivation for the new radar. Traditionally bistatic radars have had excellent time resolution, but were significantly lacking in range resolution. With the now available accurate timing abilities and advanced pulse modulation techniques, bistatic radar configurations with both excellent temporal and spatial resolution are able to map or 'image' the E-region. The E-region portion of the ionosphere being the base of the magnetosphere has both global (ionosphere-magnetosphere system) and local phenomena of interest. The currents in the magnetosphere close in the E-region. Field-aligned currents (FACs) and Alfven waves are phenomena with origins in the magnetosphere which present their 'signatures' in the E-region. For example, Alfven waves (produced by the Alfven wave resonator) have different time scales, from less than a Hertz to periods of tens of minutes --- and the high temporal and spatial resolution of this new digital E-region radar will be able to detect them all. The E-region is also a dynamic plasma medium with the two-steam and gradient drift instabilities present and the improved measurement abilities will give fresh physical insight.

  13. Measurements of sigma(e^+ e^- -> Upsilon(nS)pi^+pi^-) and sigma(e^+ e^- -> b bbar) in the Upsilon(10860) and Upsilon(11020) resonance regions

    CERN Document Server

    Santel, D; Chang, P; Abdesselam, A; Adachi, I; Aihara, H; Said, S Al; Arinstein, K; Asner, D M; Aushev, T; Ayad, R; Bakich, A M; Bansal, V; Bhuyan, B; Bobrov, A; Bondar, A; Bonvicini, G; Bračko, M; Browder, T E; Červenkov, D; Chekelian, V; Cheon, B G; Chilikin, K; Cho, K; Chobanova, V; Choi, S -K; Choi, Y; Cinabro, D; Dalseno, J; Danilov, M; Dingfelder, J; Doležal, Z; Drásal, Z; Drutskoy, A; Eidelman, S; Farhat, H; Fast, J E; Ferber, T; Gaur, V; Gabyshev, N; Garmash, A; Getzkow, D; Gillard, R; Goh, Y M; Haba, J; Hara, T; Hayasaka, K; Hayashii, H; He, X H; Hou, W -S; Hyun, H J; Iijima, T; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, Y; Jaegle, I; Joffe, D; Julius, T; Kang, K H; Kato, E; Kawasaki, T; Kiesling, C; Kim, D Y; Kim, H J; Kim, J B; Kim, J H; Kim, M J; Kim, S H; Kim, Y J; Ko, B R; Kodyš, P; Korpar, S; Križan, P; Krokovny, P; Kuzmin, A; Lange, J S; Lee, I S; Li, Y; Gioi, L Li; Libby, J; Liventsev, D; Lukin, P; Matvienko, D; Miyabayashi, K; Miyata, H; Mizuk, R; Mohanty, G B; Moll, A; Mori, T; Mussa, R; Nakano, E; Nakao, M; Nanut, T; Natkaniec, Z; Nisar, N K; Nishida, S; Ogawa, S; Okuno, S; Olsen, S L; Oswald, C; Pakhlov, P; Pakhlova, G; Park, C W; Park, H; Pedlar, T K; Petrič, M; Piilonen, L E; Ribežl, E; Ritter, M; Rostomyan, A; Ryu, S; Sakai, Y; Sandilya, S; Santelj, L; Sanuki, T; Savinov, V; Schneider, O; Schnell, G; Schwanda, C; Schwartz, A J; Senyo, K; Sevior, M E; Shebalin, V; Shibata, T -A; Shiu, J -G; Shwartz, B; Sibidanov, A; Simon, F; Sohn, Y -S; Solovieva, E; Starič, M; Steder, M; Tamponi, U; Tatishvili, G; Teramoto, Y; Trabelsi, K; Uchida, M; Uglov, T; Unno, Y; Uno, S; Van Hulse, C; Vanhoefer, P; Varner, G; Vinokurova, A; Wagner, M N; Wang, P; Wang, X L; Watanabe, M; Watanabe, Y; Won, E; Yamaoka, J; Yang, Y -P; Yashchenko, S; Yook, Y; Yusa, Y; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A

    2016-01-01

    We report new measurements of $R_{\\Upsilon\\pi\\pi}\\equiv\\sigma(e^+e^-\\to \\Upsilon(n{\\rm S})\\pi^+\\pi^-)/\\sigma^0_{\\mu\\mu}$ ($n$ = 1, 2, 3) and $R_b\\equiv\\sigma(e^+e^-\\to b\\bar b)/\\sigma^0_{\\mu\\mu}$ (where $\\sigma^0_{\\mu\\mu}$ is the muon-pair Born cross section) in the region $\\sqrt{s} = 10.63$-$11.05$ GeV, based on data collected with the Belle detector. Distributions in $R_{\\Upsilon\\pi\\pi}$ and $R_b$ are fit for the masses and widths of the $\\Upsilon(10860)$ and $\\Upsilon(11020)$ resonances. Unlike $R_b$, which includes a large non-resonant $b\\bar{b}$ component, we find that $R_{\\Upsilon\\pi\\pi}$ is dominated by the two resonances. With $R_{\\Upsilon\\pi\\pi}$ as the basis, the total rate at the $\\Upsilon(10860)$ peak for known final states containing bottomonium(-like) resonances is estimated. We find that $\\Upsilon(10860)$ is essentially saturated by such modes, raising doubts about the validity of masses measured using $R_b$. With $R_{\\Upsilon\\pi\\pi}$, we measure $M_{10860}=(10891.1\\pm3.2^{+0.6}_{-1.5})$ MeV/$c...

  14. 7 CFR Exhibit E to Subpart E of... - List of Regional Offices, Office of Federal Contract Compliance Programs (OFCCP), U.S. Department...

    Science.gov (United States)

    2010-01-01

    ... Compliance Programs (OFCCP), U.S. Department of Labor (USDL) E Exhibit E to Subpart E of Part 1901... REGULATIONS PROGRAM-RELATED INSTRUCTIONS Civil Rights Compliance Requirements Pt. 1901, Subpt. E, Exh. E Exhibit E to Subpart E of Part 1901—List of Regional Offices, Office of Federal Contract...

  15. A classification of spectral populations observed in HF radar backscatter from the E region auroral electrojets

    Directory of Open Access Journals (Sweden)

    S. E. Milan

    Full Text Available Observations of HF radar backscatter from the auroral electrojet E region indicate the presence of five major spectral populations, as opposed to the two predominant spectral populations, types I and II, observed in the VHF regime. The Doppler shift, spectral width, backscatter power, and flow angle dependencies of these five populations are investigated and described. Two of these populations are identified with type I and type II spectral classes, and hence, are thought to be generated by the two-stream and gradient drift instabilities, respectively. The remaining three populations occur over a range of velocities which can greatly exceed the ion acoustic speed, the usual limiting velocity in VHF radar observations of the E region. The generation of these spectral populations is discussed in terms of electron density gradients in the electrojet region and recent non-linear theories of E region irregularity generation.

    Key words. Ionosphere (ionospheric irregularities

  16. Autonomia, integração regional e política externa brasileira: Mercosul e Unasul

    Directory of Open Access Journals (Sweden)

    Tullo Vigevani

    2014-06-01

    Full Text Available O objetivo deste artigo é discutir a forma como a ideia e a práxis de autonomia na política externa brasileira se relacionam com as posições do país nos processos de integração regional no Cone Sul e, de forma mais ampla, na América do Sul, no período de 1991 a 2012. Discutimos o significado de autonomia em termos de políticas brasileiras para a região, bem como suas consequências para os próprios processos e as organizações subcontinentais. Identificamos mudanças e continuidades na ideia de autonomia e de que modo incidem ou não na consolidação das organizações, particularmente, o Mercosul e a Unasul. A partir da análise da literatura pertinente e de parte da documentação primária, concluímos que há ambiguidades, mas a tendência que prevalece é a do interesse pelo fortalecimento da cooperação e mesmo da integração. O interesse no fortalecimento da democracia e da paz surgem como centrais no período analisado.

  17. Necessity of the stalk region for immunoglobulin E interaction with CD23.

    Science.gov (United States)

    Chen, Bing-Hung; Ma, Check; Caven, Timothy H; Chan-Li, Yee; Beavil, Andrew; Beavil, Rebecca; Gould, Hannah; Conrad, Daniel H

    2002-11-01

    Previously, a soluble mouse CD23 chimera, composed of an N-terminal trimeric isoleucine zipper motif (lz) followed by the entire extracellular region (amino acids 48-331) of CD23 (lz-CD2348-331), was prepared and exhibited strong binding to rodent immunoglobulin E (IgE). In the current study, we report the construction of a similar human chimeric protein (lz-huCD2345-321), as well as a series of murine chimeric lz-CD23 mutants with incremental portions of stalk deleted, to further investigate the role of the stalk region in mediating the CD23-IgE interaction. All chimeric proteins were designed such that the predicted heptad structure of the stalk was retained. IgE binding, as determined by the capacity to inhibit 125I-IgE from binding to FcepsilonRI-bearing RBL-2H3 cells, and by surface plasmon-resonance analysis using an IgE-coated sensor chip, was unchanged from the original lz chimera and the binding parameters were similar to those of cell-surface CD23. The minimal murine chimera that retained IgE-binding activity was lz-CD23139-331, which still contains 35 amino acids of the stalk region. When the lz motif was linked to CD23 amino acid 157 (or higher), significant IgE-binding capacity was lost. With human lz-CD23, as with mouse, deletion of the stalk greatly reduced IgE-binding ability. In summary, the data support the concept that at least a portion of the stalk region of CD23 plays a crucial role in maintaining high-affinity/avidity interaction with IgE. The lz-CD23 constructs represent a possible alternative for both blocking the IgE/FcepsilonRI interaction and inhibiting IgE production by B lymphocytes.

  18. XANTHOLININI DELLA CINA, DELLA REGIONE ORIENTALE E DELL’AUSTRALIA. NUOVE SPECIE E NUOVI DATI GEONEMICI (COLEOPTERA, STAPHYLINIDAE

    Directory of Open Access Journals (Sweden)

    Arnaldo Bordoni

    2009-10-01

    Full Text Available L’autore descrive Erymus sinicus n. sp. del Fujian, affine a E. dalianus Bordoni dello Yunnan; Atopolinus brunneus n. sp. del Sichuan, affine a A. mirandus Bordoni del Meghalaya. Vengono forniti nuovi dati geonemici sugli Xantholinini della Cina e della Corea. L’autore descrive inoltre Thyreocephalus nigricantis n. sp. della Penisola Malese, affine a T. perakensis Bordoni della stessa Malesia, T. catastrophicus n. sp. delle isole della Sonda, caratteristico per la forma e la punteggiatura del capo, e Symilla cardamonica n. sp. del Tamil Nadu (India, affine a S. pulchra Bordoni e S. deplumis Bordoni dell’India meridionale e fornisce nuovi dati geonemici per altri Xantholinini della Regione Orientale. L’autore descrive infine Australinus bispinosus n. sp. dell’Australia, affine a A. sexsulciceps (Lea della stessa isola e Mitomorphus habbemanus n. sp. dell’Irian Jaya, isolato dalle congeneri per dimensioni, colorazione e punteggiatura; sono elencati nuovi dati geonemici relativi ad altri Xantholinini dell’Australia. Le seguenti specie sono nuove per le regioni indicate: Stenistoderus sinicus (Corea, Thyreocephalus amphidaseus (Pakistan, Adhavara ferrugunea (Cina, Phacophallus japonicus (Cambogia, Xanthophius filum (Cambogia, Yunna micophora (Shaanxi.

  19. Precision Measurement of the Spin Dependent Asymmetry in the Threshold Region of {sup 3}He(e,e{prime})

    Energy Technology Data Exchange (ETDEWEB)

    F. Xiong; Dipangkar Dutta; W. Xu (MIT; LNS); Bryon Anderson; L. Auberbach; Todd Averett; William Bertozzi; Timothy Black; John Calarco; Larry Cardman; Gorden Cates; Zhengwei Chai; Jian-ping Chen; Seonho Choi; Eugene Chudakov; Steve Churchwell; G.S. Corrado; C. Crawford; Dan Dale; Alexandre Deur; Pibaro Djawotho; Bradley Filippone; Mike Finn; Haiyan Gao; Ron Gilman; Alexander Glamazdin; Charles Glashausser; W. Glockle; J. Golak; Javier Gomez; Victor Gorbenko; Jens-Ole Hansen; F. William Hersman; Douglas W. Higinbotham; Richard Holmes; C.R. Howell; E. Hughes; B. Humensky; Sebastian Incerti; Kees de Jager; J.Steffen Jensen; Xiangdong Jiang; C.E. Jones; Mark Jones; R. Kahl; H. Kamada; A. Kievsky; Ioannis Kominis; Wolfgang Korsch; Kevin Kramer; Gerfried Kumbartzki; Michael Kuss; E. Lakuriqi; Meme Liang; Nilanga Liyanage; John LeRose; Sergey Malov; Dimitri Margaziotis; Jeffrey Martin; Kathy McCormick; Robert McKeown; K. McIlhany; Zein-Eddine Meziani; Robert Michaels; G.W. Miller; E. Pace; T. Pavlin; Gerassimos G. Petratos; R.I. Pomatsalyuk; D. Pripstein; David Prout; Ronald Ransome; Yves Roblin; Marat Rvachev; Arun Saha; G. Salme; M. Schnee; Taeksu Shin; Karl Slifer; Paul Souder; Steffen Strauch; Riad Suleiman; M. Sutter; Bryan Tipton; Luminita Todor; M. Viviani; B. Vlahovic; J. Watson; C.F. Williamson; H. Witala; Bogdan B. Wojtsekhowski; J. Yeh; P. Zolnierczuk

    2001-12-10

    We present the first precision measurement of the spin-dependent asymmetry in the threshold region of {sup 3}He(e,e{prime}) at Q{sup 2}-values of 0.1 and 0.2 (GeV/c){sup 2}. The agreement between the data and non-relativistic Faddeev calculations which include both final-state interactions (FSI) and meson-exchange currents (MEC) effects is very good at Q{sup 2} = 0.1 (GeV/c){sup 2}, while a small discrepancy at Q{sup 2} = 0.2 (GeV/c){sup 2} is observed.

  20. Study on E- tourism and Sustainability in Ethnic Minority Regions of West Sichuan

    Institute of Scientific and Technical Information of China (English)

    范雨涛

    2013-01-01

    This paper introduces the current situation of sustainable development in the ethnic minority regions in west Sichuan province of China, and the challenges they are confronted,especially after the devastating 2008 Wenchuan earthquake. The author argues that E-tourism can be introduced into these regions to support the tourism industry, one of the pillar industries in these regions, and expounds the necessity and significance to develop E-tourism. The paper also sets forth some strategies and countermeasures to foster the sustainable development by applying ICT to develop the E-tourism market and enhance the competitiveness and attraction with the aid of education, involvement of higher education institutions and collaboration in every level.

  1. Memory and regional identity in Udihara’s cinema Memória e identidade regional no cinema de Udihara

    Directory of Open Access Journals (Sweden)

    Caio Júlio Cesaro

    2007-01-01

    Full Text Available The cinema produced by the Japanese immigrant Hikoma Udihara, for over 30 years, is a record of the first decades of colonization in Northern of Paraná. The content – a little more than 10 hours of images – constitutes essence of the memory and identity in the region. A file which, in spite of private and institutional efforts for its maintenance, is vanishing and deteriorating quickly. For this reason, urgent action is required for recuperation and preservation. O cinema produzido pelo imigrante japonês Hikoma Udihara, ao longo de mais de 30 anos, documenta as primeiras décadas da colonização do Norte do Paraná. O conteúdo – de pouco mais de dez horas de imagens – constitui-se essência da memória e da identidade da região. Um acervo que, apesar de esforços particulares e institucionais para sua manutenção, está esvaecendo e se desintegrando rapidamente. Em razão disso, necessita de ações urgentes de recuperação e preservação.

  2. Mid-latitude E-region bulk motions inferred from digital ionosonde and HF radar measurements

    Directory of Open Access Journals (Sweden)

    J. Delloue

    2004-11-01

    Full Text Available In the mid-latitude E-region there is now evidence suggesting that neutral winds play a significant role in driving the local plasma instabilities and electrodynamics inside sporadicE layers. Neutral winds can be inferred from coherent radar backscatter measurements of the range-/azimuth-time-intensity (RTI/ATI striations of quasi-periodic (QP echoes, or from radar interferometer/imaging observations. In addition, neutral winds in the E-region can be estimated from angle-of-arrival ionosonde measurements of sporadic-E layers. In the present paper we analyse concurrent ionosonde and HF coherent backscatter observations obtained when a Canadian Advanced Digital Ionosonde (CADI was operated under a portion of the field-of-view of the Valensole high frequency (HF radar. The Valensole radar, a mid-latitude radar located in the south of France with a large azimuthal scanning capability of 82° (24° E to 58° W, was used to deduce zonal bulk motions of QP echoing regions using ATI analysis. The CADI was used to measure angle-of-arrival information in two orthogonal horizontal directions and thus derive the motion of sporadic-E patches drifting with the neutral wind. This paper compares the neutral wind drifts of the unstable sporadic-E patches as determined by the two instruments. The CADI measurements show a predominantly westward aligned motion, but the measured zonal drifts are underestimated relative to those observed with the Valensole radar.

  3. Turismo e desenvolvimento regional: um estudo no Estado de São Paulo

    OpenAIRE

    Madalena Pedroso Aulicino

    2011-01-01

    Este artigo tem como objetivo demonstrar que o turismo pode ser fator de desenvolvimento regional. Para isto foram resgatadas colocações pertinentes `a problemática regional e tomados conceitos relativos a bens e produtos característicos do turismo, segundo parâmetros da Organização Mundial do Turismo – OMT, como a presença de meios de hospedagem, entre os quais se inclui as residências secundárias....

  4. The C-terminal region of E1A: a molecular tool for cellular cartography.

    Science.gov (United States)

    Yousef, Ahmed F; Fonseca, Gregory J; Cohen, Michael J; Mymryk, Joe S

    2012-04-01

    The adenovirus E1A proteins function via protein-protein interactions. By making many connections with the cellular protein network, individual modules of this virally encoded hub reprogram numerous aspects of cell function and behavior. Although many of these interactions have been thoroughly studied, those mediated by the C-terminal region of E1A are less well understood. This review focuses on how this region of E1A affects cell cycle progression, apoptosis, senescence, transformation, and conversion of cells to an epithelial state through interactions with CTBP1/2, DYRK1A/B, FOXK1/2, and importin-α. Furthermore, novel potential pathways that the C-terminus of E1A influences through these connections with the cellular interaction network are discussed.

  5. Região, desenvolvimento regional e turismo comunitário

    Directory of Open Access Journals (Sweden)

    Luzia Neide Coriolano

    2013-03-01

    Full Text Available Neste estudo, repensam-se região, desenvolvimento regional e comunidades, pelo exame de questões voltadas à solidariedade e às resistências sociais nas relações com turismo e territórios. Busca-se entender a importância do turismo no desenvolvimento regional e local, a contribuição na geração do trabalho e na práxis social nas regiões e nos núcleos receptores de turismo, aproximando-se de microterritórios, aqui chamados de comunidades. O artigo aborda o interesse por realidades regionais por meio do desenvolvimento regional que valoriza políticas locais no mundo globalizado. São pensadas possibilidades para o turismo de comunidades que, ao resistirem ao modelo hegemônico, exercitam alternativas de desenvolvimento. Levam-se em conta as especificidades locais no processo de planejamento, daí não se adotar modelo pronto, preconcebido, o que significa dizer que o turismo pode ser indicado para um lugar e para outro não. Problemas regionais diversos esperam soluções. A acelerada redução do trabalho, na forma de desemprego e exclusão aponta para nova proposta de desenvolvimento regional, do nível proposto neste trabalho, que exige redução de disparidades regionais e opções de práticas participativas, democráticas, e mecanismos para articulação de sujeitos sociais, priorizando pequenas escalas regionais.Palavras-chave | Desenvolvimento regional; lugar; região; território turístico; turismo.Código JEL | L83; O18; R10. REGION, REGIONAL DEVELOPMENT AND COMMUNITY TOURISMAbstractIn this study, region, regional development and communities are rethought by examining issues of sympathy and social resistance in relations with tourism and territories. We seek to understand the importance of tourism in regional and local development, its contribution to employment generation and social praxis in touristic regions and tourism centers in these areas from the approximation of micro-territories here called communities. In the

  6. La risorsa mare per la mobilità di merci e persone nella Regione Campania

    Directory of Open Access Journals (Sweden)

    Giuseppe Mazzeo

    2009-11-01

    Full Text Available I 512 chilometri di costa campana rappresentano il 6,7% in tutte le coste italiane (7.687 km. Su di esso si affaccia un sistema urbano consolidato formato da grandi e piccoli centri in cui le infrastrutture portuali sono storicamente presenti: si può affermare che nel corso del tempo il sistema delle attrezzature portuali e l'importanza relativa tra di loro sia cambiata, ma non ne è cambiato il numero e l'ubicazione. La morfologia della costa campana ha reso possibile l’insediamento di impianti portuali di dimensioni significative. Esso è quasi interamente sviluppato nel tratto centrale della costa campana e si basa sui porti di Napoli e Salerno (merci e passeggeri, Torre Annunziata (trasporto merci, Castellammare di Stabia (cantieristica, Pozzuoli (merci e passeggeri, oltre che sul sistema portuale, soprattutto passeggeri, di Ischia, Casamicciola, Capri, Procida e Sorrento. Questo complesso sistema ha molti punti di forza e molte carenze e, in una prospettiva di sviluppo territoriale, può dare apporti significativi all'asfittica economia regionale. Proprio per questo motivo alcuni dei processi di pianificazione che interessano la Regione si stanno concentrando sulle azioni possibili per ridare forza al rapporto secolare tra terra e mare, punti di forza del territorio campano. L'importanza di un uso produttivo della risorsa mare deriva da due considerazioni: la prima è la posizione geografica dell'Italia (e al suo interno, della Campania nel Mediterraneo, lungo le rotte tra l'Europa e l'Asia; il secondo è l'impatto potenziale del trasporto di merci e di passeggeri sul territorio e sul sistema economico campano. Analisi e risultati cambiano a seconda che si tratti il trasporto merci o quello passeggeri: nel primo caso diventa significativa la capacità infrastrutturale e il sistema produttivo locale, con le relative connessioni esterne; nel secondo caso è rilevante la valorizzazione delle potenzialità del sistema culturale e ambientale

  7. A gastronomia regional e o turismo como elementos fortalecedores da identidade cultural frente à tensão entre o global e o regional = The regional gastronomy and tourism as strengtheners elements of cultural identity facing the tension between global...

    OpenAIRE

    Simon, Everton Luiz; Etges, Virginia Elisabeta; Minasi, Sarah Marroni

    2016-01-01

    Este artigo tem por finalidade refletir sobre a importância e a influência da cultura, voltada à análise da gastronomia regional, considerando a tensão atual verificada entre o global e o regional e sua relação com a alimentação, a gastronomia e o turismo. Nas transformações promovidas pelo desenvolvimento do capitalismo, entendemos que existem forças homogeneizantes que atuam nos mais distintos territórios. Estas forças provocam uma série de transformações nos territórios em que se inserem, ...

  8. Lesion of the tuberomammillary nucleus E2-region attenuates postictal seizure protection in rats.

    Science.gov (United States)

    Jin, Chun-Lei; Zhuge, Zheng-Bing; Wu, Deng-Chang; Zhu, Yuan-Yuan; Wang, Shuang; Luo, Jian-Hong; Chen, Zhong

    2007-03-01

    Postictal seizure protection (PSP) is an endogenous anticonvulsant phenomenon that follows an epileptic seizure and inhibits the induction of further seizures. The tuberomammillary nucleus (TM), located in the posterior hypothalamus, consists of five subregions and is the sole source of histaminergic neurons in the brain. To determine whether the TM is involved in PSP in rats, we tested the effects of bilateral electrolytic lesions of the TM E2-region on seizures induced by intermittent maximal electroshock (MES). The TM E2-region lesions significantly attenuated PSP during the intermittent MES procedure. Furthermore, intracerebroventricular injection of alpha-fluoromethylhistidine (100 microg), a selective and irreversible histidine decarboxylase inhibitor, mimicked the attenuation of PSP induced by the lesion of TM E2-region. In addition, neurochemical experiments revealed that the TM E2-region lesions markedly decreased basal histamine levels in the cortex, hippocampus, brainstem and hypothalamus, but had no significant effect on basal glutamate and GABA levels. Moreover, intermittent MES induced a persistent decrease of brain histamine levels in both sham-operated and lesioned rats. These results indicate that through its intrinsic histaminergic system, the TM may exert powerful inhibitory function during the intermittent MES procedure and actively participate in the mechanisms of PSP.

  9. Observational evidence for new instabilities in the midlatitude E and F region

    Science.gov (United States)

    Hysell, David L.; Larsen, Miguel; Sulzer, Michael

    2016-11-01

    Radar observations of the E- and F-region ionosphere from the Arecibo Observatory made during moderately disturbed conditions are presented. The observations indicate the presence of patchy sporadic E (Es) layers, medium-scale traveling ionospheric disturbances (MSTIDs), and depletion plumes associated with spread F conditions. New analysis techniques are applied to the dataset to infer the vector plasma drifts in the F region as well as vector neutral wind and temperature profiles in the E region. Instability mechanisms in both regions are evaluated. The mesosphere-lower-thermosphere (MLT) region is found to meet the conditions for neutral dynamic instability in the vicinity of the patchy Es layers even though the wind shear was relatively modest. An inversion in the MLT temperature profile contributed significantly to instability in the vicinity of one patchy layer. Of particular interest is the evidence for the conditions required for neutral convective instability in the lower-thermosphere region (which is usually associated with highly stable conditions) due to the rapid increase in temperature with altitude. A localized F-region plasma density enhancement associated with a sudden ascent up the magnetic field is shown to create the conditions necessary for convective plasma instability leading to the depletion plume and spread F. The growth time for the instability is short compared to the one described by [Perkins(1973)]. This instability does not offer a simple analytic solution but is clearly present in numerical simulations. The instability mode has not been described previously but appears to be more viable than the various mechanisms that have been suggested previously as an explanation for the occurrence of midlatitude spread F.

  10. Citizen Perceptions of E-Government in the Kurdistan Region of Iraq

    Directory of Open Access Journals (Sweden)

    Khosro Mohammad Ahmed

    2015-11-01

    Full Text Available Despite increasing investment by governments globally, citizens in some countries are less willing to engage with e-government innovations. While previous studies have examined what might encourage citizens to adopt e-government services more broadly, further research is required to understand those factors that impede or enable e government adoption in countries that have, or are in the process of, transitioning to democratic self-rule. This study is the first to investigate citizen attitudes to e-government adoption in the Kurdistan Region of Iraq and thus provides insight into the factors affecting the adoption of e-government within an emerging democratic state. This study also distinguishes between two types of e-government services; informational and transactional. Thus a research model with two elements is developed and tested; one for intention to use informational e government and one for intention to use transactional e-government. Data were collected through a survey administered to university students and non-academic employees in Arbil the capital city of Kurdistan, and analysed using structural equation modelling. Perceived usefulness, social influence, trust in government and perceived risk were found to be significantly and directly associated with the intention to use both kinds of e-government services. However perceptions of ease of use, information quality and trust in the Internet were not significant.

  11. Characteristics of very large aspect angle E-region coherent echoes at 933 MHz

    Directory of Open Access Journals (Sweden)

    B. J. Jackel

    Full Text Available The EISCAT UHF radar system was used to study the characteristics of E-region coherent backscatter at very large magnetic aspect angles (5–11°. Data taken using 60 μs pulses during elevation scans through horizontally uniform backscatter permitted the use of inversion techniques to determine height profiles of the scattering layer. The layer was always singly peaked, with a mean height of 104 km, and mean thickness (full width at half maximum of 10 km, both independent of aspect angle. Aspect sensitivities were also estimated, with the Sodankylä-Tromsø link observing 5 dB/degree at aspect angles near 5°, decreasing to 3 dB/degree at 10° aspect angle. Observed coherent phase velocities from all three stations were found to be roughly consistent with LOS measurements of a common E-region phase velocity vector. The E-region phase velocity had the same orientation as the F-region ion drift velocity, but was approximately 50% smaller in magnitude. Spectra were narrow with skewness of about +1 (for negative velocities, increasing slightly with aspect angle.

  12. Vertical and longitudinal electron density structures of equatorial E- and F-regions

    Directory of Open Access Journals (Sweden)

    P. S. Brahmanandam

    2011-01-01

    Full Text Available From global soundings of ionospheric electron density made with FORMOSAT 3/COSMIC satellites for September 2006–August 2009, day-night variations in vertical and longitudinal structures of the electron densities in equatorial E- and F-regions for different seasons are investigated for the first time. The results reveal that the wavenumber-3 and wavenumber-4 patterns dominated the nighttime (22:00–04:00 LT F-region longitudinal structures in solstice and in equinox seasons, respectively. In daytime (08:00–18:00 LT F-region, the wavenumber-4 patterns governed the longitudinal structures in the September equinox and December solstice, and wavenumber-3 in March equinox and June solstice respectively. A comparison of the daytime and nighttime longitudinal electron density structures indicates that they are approximately 180° out of phase with each other. It is believed that this out of phase relation is very likely the result of the opposite phase relation between daytime and nighttime nonmigrating diurnal tidal winds that modulate background E-region dynamo electric field at different places, leading to the day-night change in the locations of the equatorial plasma fountains that are responsible for the formation of the F-region longitudinal structures. Further, a good consistency between the locations of the density structures in the same seasons of the different years for both daytime and nighttime epochs has been noticed indicating that the source mechanism for these structures could be the same.

  13. Long-term trends in the ionospheric E and F1 regions

    Directory of Open Access Journals (Sweden)

    J. Bremer

    2008-05-01

    Full Text Available Ground based ionosonde measurements are the most essential source of information about long-term variations in the ionospheric E and F1 regions. Data of such observations have been derived at many different ionospheric stations all over the world some for more than 50 years. The standard parameters foE, h'E, and foF1 are used for trend analyses in this paper. Two main problems have to be considered in these analyses. Firstly, the data series have to be homogeneous, i.e. the observations should not be disturbed by artificial steps due to technical reasons or changes in the evaluation algorithm. Secondly, the strong solar and geomagnetic influences upon the ionospheric data have carefully to be removed by an appropriate regression analysis. Otherwise the small trends in the different ionospheric parameters cannot be detected.

    The trends derived at individual stations differ markedly, however their dependence on geographic or geomagnetic latitude is only small. Nevertheless, the mean global trends estimated from the trends at the different stations show some general behaviour (positive trends in foE and foF1, negative trend in h'E which can at least qualitatively be explained by an increasing atmospheric greenhouse effect (increase of CO2 content and other greenhouse gases and decreasing ozone values. The positive foE trend is also in qualitative agreement with rocket mass spectrometer observations of ion densities in the E region. First indications could be found that the changing ozone trend at mid-latitudes (before about 1979, between 1979 until 1995, and after about 1995 modifies the estimated mean foE trend.

  14. Regional E-Infrastructure and Services for Research and Education in EAP Countries

    Directory of Open Access Journals (Sweden)

    Petru BOGATENCOV

    2017-06-01

    Full Text Available In the paper considering approaches and solutions for development of modern regional e-Infrastructure resources for providing specific services to the research and educational communities in countries supported by European Eastern Partnership Programme. Over the past several years the dependence of research and education on access to high-speed networking infrastructures, to large-scale computing and other e-Infrastructures’ services is rapidly increasing. e-Infrastructure designates a new generation of integrated ICT based resources, services and is widely considered as a key enabler for scientific and social development. Such infrastructures represent a distributed medium based on high-bandwidth networks, distributed Grid computing, High Performance Computing (HPC, scientific Cloud resources and respective data repositories. The focus is made on describing the various services that are deploying in the Eastern Partnership countries to support educational and research activities in universities and research centers. Argued importance of developing of Research and Educational networks as a key e-Infrastructures’ enables. Described expected outcomes of regional projects supported by European Commission in the area on regional infrastructures and modern services deployment for research and education.

  15. Flare X-ray photochemistry of the E region ionosphere of Mars

    Science.gov (United States)

    Haider, S. A.; Batista, I. S.; Abdu, M. A.; Santos, A. M.; Shah, Siddhi Y.; Thirupathaiah, P.

    2016-07-01

    Based on electron density profiles obtained from the Mars Global Surveyor (MGS) we report X-ray flare responses in the E region ionosphere of Mars during six events that occurred on 28 March and 6 April 2001, 17 and 18 March and 21 April 2003, and 19 February 2005. We have developed a time-dependent Analytical Yield Spectrum model to calculate a time series of photoionization rate, photoelectron impact ionization rate, photoelectron flux, ion density, electron density, and ionospheric electron content (IEC) of the E region for each flare day. The estimated production rate, flux, and densities increase by 1-2 orders of magnitude due to effect of these flares in the E region ionosphere of Mars. The estimated IEC are compared with the measured IEC. It is found that the normalized IEC of the simulated E layer increased by a factor of 5-10 at the flare time compared to a factor of 2 enhancements in the normalized IEC of the corresponding MGS profiles.

  16. More evidence for a planetary wave link with midlatitude E region coherent backscatter and sporadic E layers

    Directory of Open Access Journals (Sweden)

    K. Schlegel

    Full Text Available Measurements of midlatitude E region coherent backscatter obtained during four summers with SESCAT, a 50 MHz Doppler system operating in Crete, Greece, and concurrent ionosonde recordings from the same ionospheric volume obtained with a CADI for one of these summers, are used to analyse the long-term variability in echo and Es occurrence. Echo and Es layer occurrences, computed in percent of time over a 12-h nighttime interval, take the form of time sequences. Linear power spectrum analysis shows that there are dominant spectral peaks in the range of 2–9 days, the most commonly observed periods appearing in two preferential bands, of 2–3 days and 4–7 days. No connection with geomagnetic activity was found. The characteristics of these periodicities compare well with similar properties of planetary waves, which suggests the possibility that planetary waves are responsible for the observed long-term periodicities. These findings indicate also a likely close relation between planetary wave (PW activity and the well known but not well understood seasonal Es dependence. To test the PW postulation, we used simultaneous neutral wind data from the mesopause region around 95 km, measured from Collm, Germany. Direct comparison of the long-term periodicities in echo and Es layer occurrence with those in the neutral wind show some reasonable agreement. This new evidence, although not fully conclusive, is the first direct indication in favour of a planetary wave role on the unstable midlatitude E region ionosphere. Our results suggest that planetary waves observation is a viable option and a new element into the physics of midlatitude Es layers that needs to be considered and investigated.Key words: Ionosphere (ionosphere irregularities; mid-latitude ionosphere – Meteorology and atmospheric dynamics (waves and tides

  17. The effects of density-dependent form factors for (e, e'p) reaction in quasi-elastic region

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K.S. [Korea Aerospace University, School of Liberal Arts and Science, Goyang (Korea, Republic of); Cheoun, Myung-Ki [Soongsil University, Department of Physics, Seoul (Korea, Republic of); Kim, Hungchong [Kookmin University, Department of General Education, Seoul (Korea, Republic of); So, W.Y. [Kangwon National University at Dogye, Department of Radiological Science, Samcheok (Korea, Republic of)

    2016-04-15

    Within the framework of a relativistic single particle model, the effects of density-dependent electromagnetic form factors on the exclusive (e, e'p) reaction are investigated in the quasi-elastic region. The density-dependent electromagnetic form factors are generated from a quark-meson coupling model and used to calculate the cross sections in two different densities, either at the normal density of ρ{sub 0} ∝ 0.15 fm{sup -3} or at the lower density, 0.5ρ{sub 0}. Then these cross sections are analyzed in the two different kinematics: One is that the momentum of the outgoing nucleon is along the momentum transfer. The other is that the angle between the momentum of the outgoing nucleon and the momentum transfer is varied at fixed magnitude of the momentum of the outgoing nucleon. Our theoretical differential reduced cross sections are compared with the NIKHEF data for the {sup 208}Pb(e, e'p) reaction, which is related to the probability that a bound nucleon from a given orbit can be knocked-out of the nucleus. The effects of the density-dependent form factors increase the differential cross sections for both knocked-out proton and neutron by an amount of a few percent. Moreover they are shown to be almost the same within only a few percent, i.e., nearly independent of the shell location of knockout nucleons. These results are quite consistent with the characteristics of double magic nuclei which have relatively sharp smearing in the density distribution. (orig.)

  18. Estudo comparativo do fluxo sanguineo cerebral regional (SPECT) entre pacientes esquizofrenicos e controle normais

    OpenAIRE

    1998-01-01

    A esquizofrenia é um distúrbio psicótico grave, que acomete preferencialmente adultos jovens, causando danos que se prolongam durante toda a vida do indivíduo. É de etiologia multifatorial com aspectos genéticos, ambientais e neurobiológicos implicados na sua gênese. As técnicas de neuroimagem têm demonstrado alterações do metabolismo e do fluxo Sangüíneo Cerebral- regional (FSCr). Neste estudo, objetivamos verificar as alterações do FSCr em esquizofrênicos, quando comparados a controles nonn...

  19. Estudo comparativo do fluxo sanguineo cerebral regional (SPECT) entre pacientes esquizofrenicos e controle normais

    OpenAIRE

    1998-01-01

    Resumo: A esquizofrenia é um distúrbio psicótico grave, que acomete preferencialmente adultos jovens, causando danos que se prolongam durante toda a vida do indivíduo. É de etiologia multifatorial com aspectos genéticos, ambientais e neurobiológicos implicados na sua gênese. As técnicas de neuroimagem têm demonstrado alterações do metabolismo e do fluxo Sangüíneo Cerebral- regional (FSCr). Neste estudo, objetivamos verificar as alterações do FSCr em esquizofrênicos, quando comparados a contro...

  20. Both viral E2 protein and the cellular factor PEBP2 regulate transcription via E2 consensus sites within the bovine papillomavirus type 4 long control region.

    OpenAIRE

    Jackson, M E; Campo, M S

    1995-01-01

    The bovine papillomavirus type 4 (BPV4) long control region (LCR) contains three consensus binding sites, E2(1), E2(2), and E2(3) (ACCN6GGT), for the viral E2 transcription factor and a fourth degenerate site, dE2 (ATCN6GGT), which lies 3 bp upstream of E2(3). The E2(2) site was found to bind the cellular transcription factor PEBP2, and mutations at this site reduced basal promoter activity by as much as 60%, indicating an important role for PEBP2 in LCR function. Mutation of the E2(3) or dE2...

  1. E- and F- region incoherent scatter radar spectral measurements at mid and low-latitudes

    Science.gov (United States)

    Kudeki, Erhan; Milla, Marco

    2016-07-01

    In this talk we will contrast and compare incoherent scatter radar spectral measurements conducted using the Arecibo, ALTAIR, and Jicamarca incoherent scatter radars at ionospheric heights ranging from E-region into the topside F-region. Arecibo measurements from mid-latitudes exemplify high SNR ISR techniques utilized with large magnetic aspect angles. Low-latitude measurements at ALTAIR and Jicamarca make use of and combine large and small magnetic aspect angle techniques. Examples presented will include both natural and naturally enhanced electron and ion lines detected in the lower F region near the geomagnetic equator as well as the results of search for proton gyro-resonance peaks in the Jicamarca topside spectra.

  2. 30 MHz radar observations of artificial E region field-aligned plasma irregularities

    Directory of Open Access Journals (Sweden)

    D. L. Hysell

    2008-02-01

    Full Text Available Artificial E region field aligned irregularities (FAIs have been observed during heating experiments at the HAARP facility using a new 30 MHz coherent scatter radar imager deployed near Homer, Alaska. Irregularities were observed during brief experiments on three quiet days in July and August, 2007, when the daytime E region critical frequency was close to 3 MHz. Irregularities were consistently generated and detected during experiments with O-mode HF pumping on zenith with a 1-min on, 1-min off CW modulation. The scattering cross sections, rise, and fall times of the echoes were observed as well as their spectral properties. Results were found to be mainly in agreement with observations from other mid- and high-latitude sites with some discrepancies. Radar images of the irregularity-filled volume on one case exhibited clear variations in backscatter power and Doppler shift across the volume. The images furthermore show the emergence of a small irregularity-filled region to the south southwest of the main region in the approximate direction of magnetic zenith.

  3. First E- and D-region incoherent scatter spectra observed over Jicamarca

    Directory of Open Access Journals (Sweden)

    J. L. Chau

    2006-07-01

    Full Text Available We present here the first Jicamarca observations of incoherent scatter radar (ISR spectra detected from E- and D-region altitudes. In the past such observations have not been possible at Jicamarca due a combined effect of strong equatorial electrojet (EEJ clutter and hardware limitations in the receiving system. The observations presented here were made during weak EEJ conditions (i.e., almost zero zonal electric field using an improved digital receiving system with a wide dynamic range and a high data throughput.

    The observed ISR spectra from E- and D-region altitudes are, as expected, narrow and get even narrower with decreasing altitude due to increasing ion-neutral collision frequencies. Therefore, it was possible to obtain accurate spectral measurements using a pulse-to-pulse data analysis. At lower altitudes in the D-region where signal correlation times are relatively long we used coherent integration to improve the signal-to-noise ratio of the collected data samples. The spectral estimates were fitted using a standard incoherent scatter (IS spectral model between 87 and 120 km, and a Lorentzian function below 110 km. Our preliminary estimates of temperature and ion-neutral collisions frequencies above 87 km are in good agreement with the MSISE-90 model. Below 87 km, the measured spectral widths are larger than expected, causing an overestimation of the temperatures, most likely due to spectral distortions caused by atmospheric turbulence.

  4. Combined Impedance Probe and Langmuir Probe Studies of the Low-Latitude E Region

    Science.gov (United States)

    Rowland, D. E.; Pfaff, R. F.; Steigies, C. T.

    2008-01-01

    The EQUIS-2 sounding rocket and radar campaign, launched from Kwajalein Atoll in 2004, included a mission to study low-latitude irregularities and electrodynamics, led by NASA GSFC. This mission included two instrumented rockets launched into the nighttime E region (apogee near 120 km), which included comprehensive electrodynamics and neutral density instrumentation. These rockets carried the first of a new generation of impedance probes, that utilize a wide-band drive signal to simultaneously measure the impedance of an antenna in a plasma as a function of frequency from 7 kEIz to 4 MHz. at a rapid cadence. This technique promises to permit true plasma spectroscopy, and resulted in the identification of multiple plasma resonances and accurate measurements of the plasma density, even in the low density nighttime E region. We present analyses of the technique and resulting spectra, and show how these data may be combined with fixed-bias Langmuir Probe data to infer the temperature structure of the E region as well as providing accurate absolute calibrations for the very high time resolution fixed-bias probe data. The data is shown to agree well with data from ionosonde, the ALTAIR radar, and the Peruvian beacon experiment.

  5. A numerical model of the ionosphere, including the E-region above EISCAT

    Directory of Open Access Journals (Sweden)

    P.-Y. Diloy

    Full Text Available It has been previously demonstrated that a two-ion (O+ and H+ 8-moment time-dependent fluid model was able to reproduce correctly the ionospheric structure in the altitude range probed by the EISCAT-VHF radar. In the present study, the model is extended down to the E-region where molecular ion chemistry (NO+ and O+2, essentially prevails over transport; EISCAT-UHF observations confirmed previous theoretical predictions that during events of intense E×B induced convection drifts, molecular ions (mainly NO+ predominate over O+ ions up to altitudes of 300 km. In addition to this extension of the model down to the E-region, the ionization and heating resulting from both solar insolation and particle precipitation is now taken into account in a consistent manner through a complete kinetic transport code. The effects of E×B induced convection drifts on the E- and F-region are presented: the balance between O+ and NO+ ions is drastically affected; the electric field acts to deplete the O+ ion concentration. The [NO+]/[O+] transition altitude varies from 190 km to 320 km as the perpendicular electric field increases from 0 to 100 mV m-1. An interesting additional by-product of the model is that it also predicts the presence of a noticeable fraction of N+ ions in the topside ionosphere in good agreement with Retarding Ion Mass Spectrometer measurements onboard Dynamic Explorer.

  6. eHealth for Remote Regions: Findings from Central Asia Health Systems Strengthening Project.

    Science.gov (United States)

    Sajwani, Afroz; Qureshi, Kiran; Shaikh, Tehniat; Sayani, Saleem

    2015-01-01

    Isolated communities in remote regions of Afghanistan, Kyrgyz Republic, Pakistan and Tajikistan lack access to high-quality, low-cost health care services, forcing them to travel to distant parts of the country, bearing an unnecessary financial burden. The eHealth Programme under Central Asia Health Systems Strengthening (CAHSS) Project, a joint initiative between the Aga Khan Foundation, Canada and the Government of Canada, was initiated in 2013 with the aim to utilize Information and Communication Technologies to link health care institutions and providers with rural communities to provide comprehensive and coordinated care, helping minimize the barriers of distance and time. Under the CAHSS Project, access to low-cost, quality health care is provided through a regional hub and spoke teleconsultation network of government and non-government health facilities. In addition, capacity building initiatives are offered to health professionals. By 2017, the network is expected to connect seven Tier 1 tertiary care facilities with 14 Tier 2 secondary care facilities for teleconsultation and eLearning. From April 2013 to September 2014, 6140 teleconsultations have been provided across the project sites. Additionally, 52 new eLearning sessions have been developed and 2020 staff members have benefitted from eLearning sessions. Ethics and patient rights are respected during project implementation.

  7. E-Commerce Experiences in the Real Estate Industry: a preliminary study in regional Queensland

    Directory of Open Access Journals (Sweden)

    Jeanette Van Akkeren

    2003-05-01

    Full Text Available Computer systems have become commonplace in most SMEs and technology is increasingly becoming a part of doing business. In recent years, the Internet has become readily available to businesses; consequently there has been growing pressure on SMEs to take up e-commerce. However, e-commerce is perceived by many as being unproven in terms of business benefit. This research aims to determine what, if any, benefits are derived from assimilating e-commerce technologies into SME business processes. This paper presents three in-depth case studies from the Real Estate industry in a regional setting. Overall, findings were positive and identified the following experiences: enhanced business efficiencies, cost benefits, improved customer interactions and increased business return on investment.

  8. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes

    DEFF Research Database (Denmark)

    Fattaey, A R; Harlow, E; Helin, K

    1993-01-01

    overexpression of pRB or p107 in cells lacking a functional pRB leads to the repression of E2F activity. The products of the adenovirus E1A gene can disrupt E2F complexes and result in free and presumably active E2F transcription factor. The regions of E1A required for this function are also essential...

  9. Turismo e desenvolvimento regional: um estudo no Estado de São Paulo

    Directory of Open Access Journals (Sweden)

    Madalena Pedroso Aulicino

    2011-05-01

    Full Text Available

    Este artigo tem como objetivo demonstrar que o turismo pode ser fator de desenvolvimento regional. Para isto foram resgatadas colocações pertinentes `a problemática regional e tomados conceitos relativos a bens e produtos característicos do turismo, segundo parâmetros da Organização Mundial do Turismo – OMT, como a presença de meios de hospedagem, entre os quais se inclui as residências secundárias. Para verificação da hipótese, selecionou-se dois conjuntos de municípios do Estado de São Paulo diferenciados pela presença ou não da atividade turística. Os municípios foram então avaliados a partir da Técnica do Quociente Locacional da Teoria da Base Econômica Regional, que mede a relação de empregos básicos (que atendem não residentes e estimulam a geração de outros empregos em setores da economia local em comparação com uma unidade espacial maior como o estado. No caso dos municípios, aplicou-se o Quociente Locacional nos dados de empregos gerados em hotéis, demonstrando-se a partir daí que o turismo pode se constituir em fator de desenvolvimento regional, a partir dos parâmetros estabelecidos.

  10. Characteristics of very large aspect angle E-region coherent echoes at 933 MHz

    Science.gov (United States)

    Jackel, B. J.; Moorcroft, D. R.; Schlegel, K.

    1997-01-01

    The EISCAT UHF radar system was used to study the characteristics of E-region coherent backscatter at very large magnetic aspect angles (5-11°). Data taken using 60 s pulses during elevation scans through horizontally uniform backscatter permitted the use of inversion techniques to determine height profiles of the scattering layer. The layer was always singly peaked, with a mean height of 104 km, and mean thickness (full width at half maximum) of 10 km, both independent of aspect angle. Aspect sensitivities were also estimated, with the Sodankylä-Tromsø link observing 5 dB/degree at aspect angles near 5°, decreasing to 3 dB/degree at 10° aspect angle. Observed coherent phase velocities from all three stations were found to be roughly consistent with LOS measurements of a common E-region phase velocity vector. The E-region phase velocity had the same orientation as the F-region ion drift velocity, but was approximately 50% smaller in magnitude. Spectra were narrow with skewness of about +1 (for negative velocities), increasing slightly with aspect angle. Acknowledgements. The authors are grateful to Prof. D. J. Southwood (Imperial College, London), J. C. Samson (University of Alberta, Edmonton), L. J. Lanzerotti (AT&T Bell Laboratories), A. Wolfe (New York City Technical College) and to Dr. M. Vellante (University of LÁquila) for helpful discussions. They also thank Dr. A. Meloni (Istituto Nazionale di Geofisica, Roma) who made available geomagnetic field observations from LÁquila Geomagnetic Observatory. This research activity at LÁquila is supported by MURST (40% and 60% contracts) and by GIFCO/CNR. Topical Editor K.-H. Glaßmeier thanks C. Waters and S. Fujita for their help in evaluating this paper.-> Correspondence to :P. Francia->

  11. Polarized Structure Function $\\sigma_{LT'}$ for $p({\\vec e},e'K^+)\\Lambda$ in the Nucleon Resonance Region

    CERN Document Server

    Nasseripour, R; Ambrozewicz, P; Carman, D S; Amaryan, M J; Anciant, E; Anghinolfi, M; Asavapibhop, B; Asryan, G; Audit, G; Auger, T; Avakian, H; Bagdasaryan, H; Baillie, N; Ball, J P; Baltzell, N A; Barrow, S; Battaglieri, M; Beard, K; Bedlinskiy, I; Bektasoglu, M; Bellis, M; Benmouna, N; Berman, B L; Biselli, A S; Blaszczyk, L; Bonner, B E; Bouchigny, S; Boiarinov, S; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Burkert, V D; Butuceanu, C; Calarco, J R; Careccia, S L; Casey, L; Cetina, C; Chen, S; Cheng, L; Cole, P L; Collins, P; Coltharp, P; Cords, D; Corvisiero, P; Crabb, D; Credé, V; Dale, D; Dashyan, N; De Masi, R; De Vita, R; De Sanctis, E; Degtyarenko, P V; Dennis, L; Deur, A; Dhuga, K S; Dickson, R; Djalali, C; Dodge, G E; Doughty, D; Dragovitsch, P; Dugger, M; Dytman, S; Dzyubak, O P; Egiyan, H; Egiyan, K S; El Fassi, L; Elouadrhiri, L; Eugenio, P; Fatemi, R; Fedotov, G; Feldman, G; Feuerbach, R J; Forest, T A; Fradi, A; Funsten, H; Garçon, M; Gavalian, G; Gevorgyan, N; Gilfoyle, G P; Giovanetti, K L; Girard, P; Girod, F X; Goetz, J T; Gothe, R W; Griffioen, K A; Guidal, M; Guillo, M; Guler, N; Guo, L; Gyurjyan, V; Hafidi, K; Hakobyan, H; Hanretty, C; Hardie, J; Heddle, D; Hersman, F W; Hicks, K; Hleiqawi, I; Holtrop, M; Hu, J; Hyde-Wright, C E; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Ito, M M; Jenkins, D; Jo, H S; Johnstone, J R; Joo, K; Jüngst, H G; Kalantarians, N; Kellie, J D; Khandaker, M; Kim, K Y; Kim, K; Kim, W; Klein, A; Klein, F J; Kossov, M; Krahn, Z; Kramer, L H; Kubarovski, V; Kühn, J; Kuhn, S E; Kuleshov, S V; Kuznetsov, V; Lachniet, J; Laget, J M; Langheinrich, J; Lawrence, D; Livingston, K; Lu, H Y; Lukashin, K; MacCormick, M; Manak, J J; Markov, N; Mattione, P; McAleer, S; McKinnon, B; McNabb, J W C; Mecking, B A; Mestayer, M D; Meyer, C A; Mibe, T; Mikhailov, K; Minehart, R; Mirazita, M; Miskimen, R; Mokeev, V; Moreno, B; Moriya, K; Morrow, S A; Moteabbed, M; Müller, J; Munevar, E; Mutchler, G S; Nadel-Turonski, P; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Niroula, M R; Niyazov, R A; Nozar, M; Osipenko, M; Ostrovidov, A I; Park, K; Pasyuk, E; Paterson, C; Anefalos Pereira, S; Peterson, G; Philips, S A; Pierce, J; Pivnyuk, N; Pocanic, D; Pogorelko, O; Pozdniakov, S; Preedom, B M; Price, J W; Procureur, S; Prok, Y; Protopopescu, D; Qin, L M; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Rosner, G; Rossi, P; Rubin, P D; Sabati, F; Salamanca, J; Salgado, C; Santoro, J P; Sapunenko, V; Sayre, D; Schumacher, R A; Serov, V S; Shafi, A; Sharabyan, Yu G; Sharov, D; Shvedunov, N V; Simionatto, S; Skabelin, A V; Smith, E S; Smith, L C; Sober, D I; Sokhan, D; Stavinsky, A; Stepanyan, S S; Stepanyan, S; Stokes, B E; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Tkabladze, A; Tkachenko, S; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Watts, D P; Weinstein, L B; Weygand, D P; Williams, M; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zana, L; Zhang, J; Zhao, B; Zhao, Z W

    2008-01-01

    The first measurements of the polarized structure function $\\sigma_{LT'}$ for the reaction $p(\\vec e,e'K^+)\\Lambda$ in the nucleon resonance region are reported. Measurements are included from threshold up to $W$=2.05 GeV for central values of $Q^2$ of 0.65 and 1.00 GeV$^2$, and nearly the entire kaon center-of-mass angular range. $\\sigma_{LT'}$ is the imaginary part of the longitudinal-transverse response and is expected to be sensitive to interferences between competing intermediate s-channel resonances, as well as resonant and non-resonant processes. The results for $\\sigma_{LT'}$ are comparable in magnitude to previously reported results from CLAS for $\\sigma_{LT}$, the real part of the same response. An intriguing sign change in $\\sigma_{LT'}$ is observed in the high $Q^2$ data at $W\\approx 1.9$ GeV. Comparisons to several existing model predictions are shown.

  12. A first comparison of irregularity and ion drift velocity measurements in the E-region

    Directory of Open Access Journals (Sweden)

    R. A. Makarevich

    2006-09-01

    Full Text Available E-region irregularity velocity measurements at large flow angles with the STARE Finland coherent VHF radar are considered in context of the ion and electron velocity data provided by the EISCAT tristatic radar system, CUTLASS Finland coherent HF radar, and IMAGE fluxgate magnetometers. The data have been collected during a special experiment on 27 March 2004 during which EISCAT was scanning between several E- and one F-region altitudes along the magnetic field line. Within the E-region, the EISCAT measurements at two altitudes of 110 and 115 km are considered while the electron velocity is inferred from the EISCAT ion velocity measurements at 278 km. The line-of-sight (l-o-s VHF velocity measured by STARE VHF los is compared to the ion and electron velocity components (Vi0 comp and Ve0 comp along the STARE l-o-s direction. The comparison with Ve0 comp for the entire event shows that the measurements exhibit large scatter and small positive correlation. The correlation with Ve0 comp was substantial in the first half of the interval under study when Ve0 comp was larger in magnitude. The comparison with Vi0 comp at 110 and 115 km shows a considerable positive correlation, with VHF velocity being typically larger (smaller in magnitude than Vi0 comp at 110 km (115 km so that VVHF los appears to be bounded by the ion velocity components at two altitudes. It is also demonstrated that the difference between VVHF los and Vi0 comp at 110 km can be treated, in the first approximation, as a linear function of the effective backscatter height heff also counted from 110 km; heff varies in the range 108–114 km due to the altitude integration effects in the scattering cross-section. Our results are consistent with the notion that VHF

  13. Morbidade Materna Grave e Near Misses em Hospital de Referência Regional

    Directory of Open Access Journals (Sweden)

    Márcia Lait Morse

    Full Text Available OBJETIVO: Analisar perfil epidemiológico da morbidade materna grave/near miss em uma maternidade pública de referência regional, utilizando diferentes critérios identificadores. MÉTODOS: Trata-se de um estudo descritivo de corte transversal dos casos de morbidade materna grave/near miss realizado em Hospital de referência regional entre junho e outubro de 2009, identificados a partir dos livros de registro de internação da maternidade e análise dos prontuários clínicos. Foram estudadas mulheres que, durante a gestação, parto ou puerpério, apresentaram qualquer quadro clínico compatível com os critérios definidores de morbidade materna grave/near miss de Waterstone et al., Mantel et al. e Organização Mundial de Saúde. RESULTADOS: Entre as 1.544 internações foram identificadas 89 mulheres com morbidade materna grave, considerando os critérios adotados. As razões de morbidade materna grave/near miss variaram entre 81,4 a 9,4 por 1.000 NV, dependendo do critério utilizado. O índice de Mortalidade foi de 3,2%, chegando a 23% no critério da OMS. Das 89 mulheres, apenas 40% fizeram mais de seis consultas de pré-natal e 10% não realizaram qualquer consulta. Os marcadores mais encontrados foram a pré-eclâmpsia grave seguida de hemorragia grave, internação em UTI, Síndrome HELLP e eclâmpsia. Ocorreram três mortes maternas por causas obstétricas com RMM de 280/100.000 NV e uma morte tardia. O critério da OMS se mostrou mais específico, identificando os casos mais graves, enquanto o de Waterstone foi mais sensível. CONCLUSÃO: O estudo da morbidade materna grave/near miss em um hospital de referência regional pode contribuir para o conhecimento da magnitude deste evento, como também identificar suas características e condições clínicas mais frequentes, sendo extremamente importante para o enfrentamento da morbi-mortalidade materna.

  14. A nova configuração regional brasileira e sua geografia econômica

    Directory of Open Access Journals (Sweden)

    Mauro Borges Lemos

    2003-12-01

    Full Text Available O objetivo deste trabalho é identificar a nova configuração regional brasileira, procurando delimitar seus pólos econômicos e suas áreas de influência, como base para uma proposta de nova regionalização para o Brasil. Para isto, é construída uma metodologia específica, baseada na aplicação do Modelo Gravitacional, comumente usado em estudos espaciais, por meio do Sistema de Informações Geográficas - SIG. Este procedimento possibilita a identificação das regiões-pólos e suas áreas de influência, com base no potencial de interação econômica entre as unidades espaciais e na correspondente hierarquia de poder de atração econômica no espaço. As microrregiões geográficas (MRGs do IBGE constituem a unidade espacial básica deste estudo, que se baseia nos microdados do Censo Demográfico de 1991. A base cartográfica digital foi a Malha Municipal Digital do Brasil, convertida para o Mapinfo. A regionalização final incorpora, em seus resultados, uma qualificação da fricção espacial.The aim of this paper is to identify the new regional pattern of the Brazilian economy by defining its economic poles and their areas of polarization, which will provide an economic regionalization for Brazil. The methodological tools to assign this objective will be an adapted version of the gravitational model using the Geographic Information System - GIS. This procedure will allow the identification of the influence areas for each regional pole, based on the potential interaction among the spatial units and their hierarchy in terms of economic power of attraction. The microregion of the Brazilian Statistics Bureau (IBGE will be the spatial unit of this study, which will rely on microdata of the 1991 Demographic Census. The digital cartographic base is the Brazilian Municipal Digital Network converted into the MapInfo. The results will provide a hierarchical spatial structure of macro regions, mesoregions, microregions, and

  15. Microeconomia Dinâmica e Desenvolvimento Regional à Luz da Teoria Evolucionária

    Directory of Open Access Journals (Sweden)

    Alexandre Magno de Melo Faria

    2011-05-01

    Full Text Available O presente artigo procura lançar luzes sobre a discussão da Teoria Evolucionária, teoria esta que visa encontrar os determinantes do desenvolvimento econômico e social das nações. Discute também as estruturas de mercado em ambientes competitivos e suas relações com a geração de tecnologia. A partir dos fatos estilizados, esta matriz teórica explicita que as firmas são as unidades básicas de acumulação de capital, complexas e especializadas, que estão constantemente sendo selecionadas em função de seu comportamento e sua tecnologia. Conclui-se o artigo afirmando que a evolução tecnológica é a principal variável no processo seletivo das firmas e que, em última instância, será essa que irá determinar o grau de desenvolvimento regional.

  16. Redes Colaborativas e Cadeia de Abastecimento: Uma Análise Regional Aplicada ao Setor Vitivinicula

    Directory of Open Access Journals (Sweden)

    Luísa Margarida Cagica Carvalho

    2014-11-01

    Full Text Available O aumento da complexidade e da competitividade dos mercados, assim como a imprevisibilidade gerada no actual contexto económico passaram a constituir factores envolventes de acrescida exigência para as empresas. Neste cenário, a colaboração entre empresas formando redes colaborativas assumiu-se como um tema dominante na gestão da cadeia de abastecimento e tem vindo a ser reconhecida como um factor determinante para melhorar a sua força competitiva. Este artigo tem por objectivo apresentar uma visão geral da evolução da investigação relacionada com a colaboração na cadeia de abastecimento, com particular aplicação ao setor vinícola, numa perspetiva de desenvolvimento regional. Este artigo pode dar contributos que permitem servir de referencial para o desenvolvimento de metodologias e de instrumentos que permitam monitorizar o desempenho da colaboração, bem como avaliar boas práticas que resultem da sinergia da colaboração inter-empresas e que sejam passíveis de disseminação e adopção, quer em termos de políticas públicas regionais, quer em termos empresariais.

  17. Possible interaction between thermal electrons and vibrationally excited N2 in the lower E-region

    Directory of Open Access Journals (Sweden)

    C. Z. Cheng

    2011-03-01

    Full Text Available As one of the tasks to find the energy source(s of thermal electrons, which elevate(s electron temperature higher than neutral temperature in the lower ionosphere E-region, energy distribution function of thermal electron was measured with a sounding rocket at the heights of 93–131 km by the applying second harmonic method. The energy distribution function showed a clear hump at the energy of ~0.4 eV. In order to find the reason of the hump, we conducted laboratory experiment. We studied difference of the energy distribution functions of electrons in thermal energy range, which were measured with and without EUV radiation to plasma of N2/Ar and N2/O2 gas mixture respectively. For N2/Ar gas mixture plasma, the hump is not clearly identified in the energy distribution of thermal electrons. On the other hand for N2/O2 gas mixture, which contains vibrationally excited N2, a clear hump is found when irradiated by EUV. The laboratory experiment seems to suggest that the hump is produced as a result of interaction between vibrationally excited N2 and thermal electrons, and this interaction is the most probable heating source for the electrons of thermal energy range in the lower E-region. It is also suggested that energy distribution of the electrons in high energy part may not be Maxwellian, and DC probe measures the electrons which are non Maxwellian, and therefore "electron temperature" is calculated higher.

  18. Radar observations of artificial E-region field-aligned irregularities

    Directory of Open Access Journals (Sweden)

    E. Nossa

    2009-07-01

    Full Text Available Artificial E region field aligned plasma density irregularities (FAIs were generated using HAARP in four different experimental modes and observed with a coherent scatter radar imager located 450 km to the southwest where it could detect field-aligned backscatter. The experiments were conducted in July of 2008, during the Polar Aeronomy and Radio Science Summer School (PARS, during quiet conditions in the daytime when the E layer was dense and absorption was modest. The echoes observed during zenith and magnetic zenith heating experiments were deflected from their nominally anticipated horizontal positions toward the midpoint position. The occurrence of hysteresis when heating with amplitude modulated pulses implied the development of the resonance instability, although the threshold for the onset of instability appeared to be higher than what has been predicted theoretically. Heating experiments involving pump frequencies slightly above and below the second electron gyroharmonic frequency produced no significant differences in the observed echoes. Finally, heating with a pump frequency slightly above the E region critical frequency appears to have produced FAIs at two distinct altitudes where the upper-hybrid resonance condition could be satisfied.

  19. Democracia e regionalismo chez Jean-Louis Quermonne Democracy and regionalism chez Jean-Louis Quermonne

    Directory of Open Access Journals (Sweden)

    Marcelo de Almeida Medeiros

    2008-01-01

    Full Text Available Com o intuito de contribuir para o alargamento do espectro de autores não anglófonos na literatura de Ciência Política do Brasil, o presente texto visa a (revisitar a questão da Democracia e do Regionalismo em Jean-Louis Quermonne. Ele está constituído de três partes. A primeira situa o autor no cenário da ciência política francesa através de expedita biografia. A segunda promove uma análise crítica e comparativa dos trabalhos de Quermonne que versam sobre a temática da Democracia, a saber: O governo da França sob a República, Os regimes políticos ocidentais e As políticas institucionais. A terceira parte procura estudar, também crítica e comparativamente, o pensamento de Quermonne no que toca a problemática do Regionalismo: O sistema político da União Européia, A Europa e o federalismo e A Europa em busca de legitimidade. Finalmente, o artigo traz algumas reflexões conclusivas apontando a importância do pensamento político francês em geral e de Jean-Louis Quermonne, em particular, para a ciência política contemporânea.Aiming at the development of the study of non-anglophone authors in the Political Science literature in Brazil, this text seeks to approach the issues of both Democracy and Regionalism in Jean-Louis Quermonne's bibliography. It has three parts. The first situates the author in the French political science scenario through a brief biography. The second part promotes a critical and comparative analysis of Quemonne's works on Democracy , i.e.: Le Gouvernement de la France sous la Vème République, Les régimes politiques occidentaux and Les politiques institutionnelles. The third part inquires, also critically and comparatively, about Quermonne's thinking on Regionalism: Le système politique de l'Union Européenne, L'Europe et le fédéralisme and L'Europe en quête de légitimité. Finally, this article brings some conclusive considerations, pointing out both the importance of the French, in general

  20. Adenoidectomia e tonsillectomia in etá pediatrica nel triennio 1999-2001 nella regione Piemonte

    Directory of Open Access Journals (Sweden)

    G.L. Saglione

    2003-05-01

    Full Text Available

    Introduzione: nel periodo 1999-2001, gli interventi di adenoidectomia e tonsillectomia, considerati nel loro insieme, hanno costituito, nella Regione Piemonte, la seconda causa di ricovero nella popolazione di età tra 1 e 14 anni, con differenze rilevanti tra tassi di ospedalizzazione nelle diverse Aziende Sanitarie Piemontesi.

    Obiettivi: analizzare entità e andamento temporale delle diversità geografiche individuate; ricercare eventuali disomogeneità di selezione dei pazienti e differenze organizzative- strutturali.

    Metodologia: dalle Schede di Dimissione Ospedaliera piemontesi degli anni 1999-2001, sono stati tratti: per ciascuna ASL, i tassi di ospedalizzazione dei residenti per gli interventi considerati, tramite i codici ICD9-CM; per ciascuna struttura complessa di otorinolaringoiatria attiva negli ospedali piemontesi pubblici e privati, il numero di interventi e la degenza media. Un questionario è stato inviato a tutte le Strutture Complesse di Otorinolaringoiatria presenti negli ospedali pubblici ed ex art. 41-43 piemontesi, richiedendo le caratteristiche organizzative delle unità operative, l’attività svolta negli interventi considerati, le modalità di ricovero, degenza e dimissione dei pazienti.

    Risultati: differenze rilevanti emergono nei tassi di ospedalizzazione delle singole ASL che peraltro, come quelli regionali, si mantengono costanti nel corso del triennio, andando dal 7,59 al 16,26 per 1000 abitanti nel 1999, dal 6,45 al 17,22 nel 2000 e dal 6,87 al 16,91 nel 2001. Relativamente al numero di interventi: per i residenti in Piemonte è passato da 6.037 nel 1999, a 6.177 nel 2000, per ridursi a 5.861 nel 2001; per l’attività svolta dagli ospedali piemontesi è risultato di 5.875 nel 1999, 5.993 nel 2000 e di 5.709 nel 2001. I dati, ricavati con il questionario, dimostrano disomogeneità di comportamento nei percorsi organizzativi

  1. 50 MHz continuous wave interferometer observations of the unstable mid-latitude E-region ionosphere

    Directory of Open Access Journals (Sweden)

    C. Haldoupis

    Full Text Available In this paper we describe the conversion of SESCAT (Sporadic-E SCATter experiment, a bistatic 50 MHz continuous wave (CW Doppler radar located on the island of Crete, Greece, to a single (east-west baseline interferometer. The first results show that SESCAT, which provides high quality Doppler spectra and excellent temporal resolution, has its measurement capabilities enhanced significantly when operated as an interferometer, as it can also study short-term dynamics of localized scattering regions within mid-latitude sporadic E-layers. The interferometric observations reveal that the aspect sensitive area viewed by the radar often contains a few zonally located backscatter regions, presumably blobs or patches of unstable metallic ion plasma, which drift across the radar field-of-view with the neutral wind. On average, these active regions of backscatter have mean zonal scales ranging from a few kilometers to several tens of kilometers and drift with westward speeds from ~ 20 m/s to 100 m/s, and occasionally up to 150 m/s. The cross-spectral analysis shows that mid-latitude type 1 echoes occur much more frequently than has been previously assumed and they originate in single and rather localized areas of elevated electric fields. On the other hand, typical bursts of type 2 echoes are often found to result from two adjacent regions in azimuth undergoing the same bulk motion westwards but producing scatter of opposite Doppler polarity, a fact that contradicts the notion of isotropic turbulence to which type 2 echoes are attributed. Finally, quasi-periodic (QP echoes are observed simply to be due to sequential unstable plasma patches or blobs which traverse across the radar field-of-view, sometimes in a wave-like fashion.

    Key words. Ionosphere (ionospheric irregularities; mid-latitude ionosphere; plasma waves and instabilities

  2. Nonlinear wave structures in collisional plasma of auroral E-region ionosphere

    Directory of Open Access Journals (Sweden)

    A. V. Volosevich

    Full Text Available Studies of the auroral plasma with small-scale inhomogenieties producing the VHF-radar reflections (radar aurora when observed in conditions of the saturated Farley-Buneman instability within the auroral E region, show strong nonlinear interactions and density fluctuations of 5–15%. Such nonlinearity and high fluctation amplitudes are inconsistent with the limitations of the weak turbulence theory, and thus a theory for arbitrary amplitudes is needed. To this end, a nonlinear theory is described for electrostatic MHD moving plasma structures of arbitrary amplitude for conditions throughout the altitude range of the collisional auroral E region. The equations are derived, from electron and ion motion self-consistent with the electric field, for the general case of the one-dimensional problem. They take into account nonlinearity, electron and ion inertia, diffusion, deviation from quasi-neutrality, and dynamical ion viscosity. The importance of the ion viscosity for dispersion is stressed, while deviation from the quasi-neutrality can be important only at rather low plasma densities, not typical for the auroral E region. In a small amplitude limit these equations have classical nonlinear solutions of the type of "electrostatic shock wave" or of knoidal waves. In a particular case these knoidal waves degrade to a dissipative soliton. A two-dimensional case of a quasi-neutral plasma is considered in the plane perpendicular to the magnetic field by way of the Poisson brackets, but neglecting the nonlinearity and ion inertia. It is shown that in these conditions an effective saturation can be achieved at the stationary turbulence level of order of 10%.

  3. E-region decameter-scale plasma waves observed by the dual TIGER HF radars

    Directory of Open Access Journals (Sweden)

    B. A. Carter

    2009-01-01

    Full Text Available The dual Tasman International Geospace Environment Radar (TIGER HF radars regularly observe E-region echoes at sub-auroral magnetic latitudes 58°–60° S including during geomagnetic storms. We present a statistical analysis of E-region backscatter observed in a period of ~2 years (late 2004–2006 by the TIGER Bruny Island and Unwin HF radars, with particular emphasis on storm-time backscatter. It is found that the HF echoes normally form a 300-km-wide band at ranges 225–540 km. In the evening sector during geomagnetic storms, however, the HF echoes form a curved band joining to the F-region band at ~700 km. The curved band lies close to the locations where the geometric aspect angle is zero, implying little to no refraction during geomagnetic storms, which is an opposite result to what has been reported in the past. The echo occurrence, Doppler velocity, and spectral width of the HF echoes are examined in order to determine whether new HF echo types are observed at sub-auroral latitudes, particularly during geomagnetic storms. The datasets of both TIGER radars are found to be dominated by low-velocity echoes. A separate population of storm-time echoes is also identified within the datasets of both radars with most of these echoes showing similar characteristics to the low-velocity echo population. The storm-time backscatter observed by the Bruny Island radar, on the other hand, includes near-range echoes (r<405 km that exhibit some characteristics of what has been previously termed the High Aspect angle Irregularity Region (HAIR echoes. We show that these echoes appear to be a storm-time phenomenon and further investigate this population by comparing their Doppler velocity with the simultaneously measured F- and E-region irregularity velocities. It is suggested that the HAIR-like echoes are observed only by HF radars with relatively poor geometric aspect angles when electron density is low and when the electric field is particularly

  4. Calibration of NIF neutron detectors in the energy region E<14 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Schmid, G J; Moran, M J; Koch, J A; Phillips, T W; Glebov, V Y; Sangster, T C; Stoeckl, C; Wender, S A; Morse, E C

    2004-04-09

    We examine various options for calibration of NIF neutron detectors in the energy region E<14 MeV. These options include: downscatter of D-T fusion neutrons using plastic targets; nuclear reactions at a Tandem Van de Graaf accelerator; and ''white'' neutrons from a pulsed spallation source. As an example of the spallation option, we present some calibration data that was recently obtained with a single crystal CVD diamond detector at the Weapons Neutron Research facility (WNR) at LANL.

  5. Observations of E region irregularities generated at auroral latitudes by a high-power radio wave

    Science.gov (United States)

    Djuth, F. T.; Jost, R. J.; Noble, S. T.; Gordon, W. E.; Stubbe, P.

    1985-01-01

    The initial results of a series of observations made with the high-power HF heating facility near Tromso, Norway are reported. During these experiments, attention was focused on the production of artificial geomagnetic field-aligned irregularities (AFAIs) in the auroral E region by HF waves. A mobile 46.9-MHz radar was used to diagnose the formation of AFAIs having spatial scales of 3.2 across geomagnetic field lines. The dynamic characteristics of the AFAIs are discussed within the context of current theoretical work dealing with the natural production of AFAIs in the ionosphere.

  6. Authentication Architecture for Region-Wide e-Health System with Smartcards and a PKI

    Science.gov (United States)

    Zúquete, André; Gomes, Helder; Cunha, João Paulo Silva

    This paper describes the design and implementation of an e-Health authentication architecture using smartcards and a PKI. This architecture was developed to authenticate e-Health Professionals accessing the RTS (Rede Telemática da Saúde), a regional platform for sharing clinical data among a set of affiliated health institutions. The architecture had to accommodate specific RTS requirements, namely the security of Professionals' credentials, the mobility of Professionals, and the scalability to accommodate new health institutions. The adopted solution uses short-lived certificates and cross-certification agreements between RTS and e-Health institutions for authenticating Professionals accessing the RTS. These certificates carry as well the Professional's role at their home institution for role-based authorization. Trust agreements between e-Health institutions and RTS are necessary in order to make the certificates recognized by the RTS. As a proof of concept, a prototype was implemented with Windows technology. The presented authentication architecture is intended to be applied to other medical telematic systems.

  7. Model results for the ionospheric E region: solar and seasonal changes

    Science.gov (United States)

    Titheridge, J. E.

    1997-01-01

    A new, empirical model for NO densities is developed, to include physically reasonable variations with local time, season, latitude and solar cycle. Model calculations making full allowance for secondary production, and ionising radiations at wavelengths down to 25 Å, then give values for the peak density NmE that are only 6% below the empirical IRI values for summer conditions at solar minimum. At solar maximum the difference increases to 16%. Solar-cycle changes in the EUVAC radiation model seem insufficient to explain the observed changes in NmE, with any reasonable modifications to current atmospheric constants. Hinteregger radiations give the correct change, with results that are just 2% below the IRI values throughout the solar cycle, but give too little ionisation in the E-F valley region. To match the observed solar increase in NmE, the high-flux reference spectrum in the EUVAC model needs an overall increase of about 20% (or 33% if the change is confined to the less well defined radiations at Francia->

  8. Vaccinazione antinfluenzale nella ASL RMF della Regione Lazio: verifica dei risultati e dei costi sostenuti

    Directory of Open Access Journals (Sweden)

    L. Di Marzio

    2003-05-01

    Full Text Available

    Obiettivi: la vaccinazione antinfluenzale nella
    Regione Lazio dalla campagna 1999-2000 viene
    condotta sulla base di un protocollo regionale che,
    per favorire il raggiungimento degli obiettivi stabiliti
    dal Piano Sanitario Nazionale, coinvolge i
    Medici di Medicina Generale (MMG prevedendo
    una remunerazione aggiuntiva in parte fissa (a prestazione, in parte variabile (condizionata dal risultato
    del singolo medico e della ASL.
    Gli autori si propongono una verifica dei risultati raggiunti e dei costi sostenuti dall’ultima campagna eseguita con sole risorse aziendali del 1998-99 a quella del 2002-03.

    Metodi: il protocollo regionale prevede la raccolta
    delle informazioni per ciascun vaccinato presente
    nell’anagrafe informatizzata degli assistiti aziendali
    e ciò consente la valutazione delle coperture vaccinali
    aziendale e per ciascun MMG.
    Parallelamente sono considerati costi dei vaccini
    acquistati e retribuzione aggiuntiva dei MMG.

    Risultati: esaminati gli archivi dal 1998-99 al 2002-
    03, emerge il progressivo coinvolgimento dei MMG fino al recente 97%, l’aumento inequivocabile delle dosi di vaccino somministrate (da 9.406 a 36.692 e del tasso di copertura negli anziani (dal 24,2% al 66%. Invece la percentuale dei vaccini somministrati ai ›65 diminuisce dal 85,47% al 71,77% ed aumenta a favore dei più giovani così da risultare coperture negli ultrasessantacinquenni inferiori alle attese.Con gli anni l’integrazione dell’esperienza del servizio e dei MMG ha favorito un più oculato approvvigionamento
    con diminuzione degli sprechi passando dal 15,56% nel 2000-01 all’attuale 4,45%, ma contestualmente i costi risultano decuplicati (da 90 a 938 milioni di lire per maggior numero di dosi somministrate e costo delle prestazioni dei MMG

  9. The terminal region of the E. coli chromosome localises at the periphery of the nucleoid

    Directory of Open Access Journals (Sweden)

    Stouf Mathieu

    2011-02-01

    Full Text Available Abstract Background Bacterial chromosomes are organised into a compact and dynamic structures termed nucleoids. Cytological studies in model rod-shaped bacteria show that the different regions of the chromosome display distinct and specific sub-cellular positioning and choreographies during the course of the cell cycle. The localisation of chromosome loci along the length of the cell has been described. However, positioning of loci across the width of the cell has not been determined. Results Here, we show that it is possible to assess the mean positioning of chromosomal loci across the width of the cell using two-dimension images from wide-field fluorescence microscopy. Observed apparent distributions of fluorescent-tagged loci of the E. coli chromosome along the cell diameter were compared with simulated distributions calculated using a range of cell width positioning models. Using this method, we detected the migration of chromosome loci towards the cell periphery induced by production of the bacteriophage T4 Ndd protein. In the absence of Ndd production, loci outside the replication terminus were located either randomly along the nucleoid width or towards the cell centre whereas loci inside the replication terminus were located at the periphery of the nucleoid in contrast to other loci. Conclusions Our approach allows to reliably observing the positioning of chromosome loci along the width of E. coli cells. The terminal region of the chromosome is preferentially located at the periphery of the nucleoid consistent with its specific roles in chromosome organisation and dynamics.

  10. Noninvasive visualization of adenovirus replication with a fluorescent reporter in the E3 region.

    Science.gov (United States)

    Ono, Hidetaka A; Le, Long P; Davydova, Julia G; Gavrikova, Tatyana; Yamamoto, Masato

    2005-11-15

    To overcome the inefficacy and undesirable side effects of current cancer treatment strategies, conditionally replicative adenoviruses have been developed to exploit the unique mechanism of oncolysis afforded by tumor-specific viral replication. Despite rapid translation into clinical trials and the established safety of oncolytic adenoviruses, the in vivo function of these agents is not well understood due to lack of a noninvasive detection system for adenovirus replication. To address this issue, we propose the expression of a reporter from the adenovirus E3 region as a means to monitor replication. Adenovirus replication reporter vectors were constructed with the enhanced green fluorescent protein (EGFP) gene placed in the deleted E3 region under the control of the adenoviral major late promoter while retaining expression of the adenovirus death protein to conserve the native oncolytic capability of the virus. Strong EGFP fluorescence was detected from these vectors in a replication-dependent manner, which correlated with viral DNA replication. Fluorescence imaging in vivo confirmed the ability to noninvasively detect fluorescent signal during replication, which generally corresponded with the underlying level of viral DNA replication. EGFP representation of viral replication was further confirmed by Western blot comparison with the viral DNA content in the tumors. Imaging reporter expression controlled by the adenoviral major late promoter provides a viable approach to noninvasively monitor adenovirus replication in preclinical studies and has the potential for human application with clinically relevant imaging reporters.

  11. Automated detection of diagnostically relevant regions in H&E stained digital pathology slides

    Science.gov (United States)

    Bahlmann, Claus; Patel, Amar; Johnson, Jeffrey; Ni, Jie; Chekkoury, Andrei; Khurd, Parmeshwar; Kamen, Ali; Grady, Leo; Krupinski, Elizabeth; Graham, Anna; Weinstein, Ronald

    2012-03-01

    We present a computationally efficient method for analyzing H&E stained digital pathology slides with the objective of discriminating diagnostically relevant vs. irrelevant regions. Such technology is useful for several applications: (1) It can speed up computer aided diagnosis (CAD) for histopathology based cancer detection and grading by an order of magnitude through a triage-like preprocessing and pruning. (2) It can improve the response time for an interactive digital pathology workstation (which is usually dealing with several GByte digital pathology slides), e.g., through controlling adaptive compression or prioritization algorithms. (3) It can support the detection and grading workflow for expert pathologists in a semi-automated diagnosis, hereby increasing throughput and accuracy. At the core of the presented method is the statistical characterization of tissue components that are indicative for the pathologist's decision about malignancy vs. benignity, such as, nuclei, tubules, cytoplasm, etc. In order to allow for effective yet computationally efficient processing, we propose visual descriptors that capture the distribution of color intensities observed for nuclei and cytoplasm. Discrimination between statistics of relevant vs. irrelevant regions is learned from annotated data, and inference is performed via linear classification. We validate the proposed method both qualitatively and quantitatively. Experiments show a cross validation error rate of 1.4%. We further show that the proposed method can prune ~90% of the area of pathological slides while maintaining 100% of all relevant information, which allows for a speedup of a factor of 10 for CAD systems.

  12. Construction of a fosmid library of cucumber (Cucumis sativus) and comparative analyses of the eIF4E and eIF(iso)4E regions from cucumber and melon (Cucumis melo).

    Science.gov (United States)

    Meyer, J D F; Deleu, W; Garcia-Mas, J; Havey, M J

    2008-05-01

    A fosmid library of cucumber was synthesized as an unrestricted resource for researchers and used for comparative sequence analyses to assess synteny between the cucumber and melon genomes, both members of the genus Cucumis and the two most economically important plants in the family Cucurbitaceae. End sequencing of random fosmids produced over 680 kilobases of cucumber genomic sequence, of which 25% was similar to ribosomal DNAs, 25% to satellite sequences, 20% to coding regions in other plants, 4% to transposable elements, 13% to mitochondrial and chloroplast sequences, and 13% showed no hits to the databases. The relatively high frequencies of ribosomal and satellite DNAs are consistent with previous analyses of cucumber DNA. Cucumber fosmids were selected and sequenced that carried eukaryotic initiation factors (eIF) 4E and iso(4E), genes associated with recessively inherited resistances to potyviruses in a number of plants. Indels near eIF4E and eIF(iso)4E mapped independently of the zym, a recessive locus conditioning resistance to Zucchini yellow mosaic virus, establishing that these candidate genes are not zym. Cucumber sequences were compared with melon BACs carrying eIF4E and eIF(iso)4E and revealed extensive sequence conservation and synteny between cucumber and melon across these two independent genomic regions. This high degree of microsynteny will aid in the cloning of orthologous genes from both species, as well as allow for genomic resources developed for one Cucumis species to be used for analyses in other species.

  13. Sistemas de inovação e promoção tecnológica regional e local no Brasil

    OpenAIRE

    Veloso Filho, Francisco de Assis; Nogueira, Jorge Madeira

    2006-01-01

    Reconhecer a importância do conhecimento para o desenvolvimento econômico renovou os debates sobre o tema do desenvolvimento regional. O Sistema Nacional de Desenvolvimento Científico e Tecnológico (SNDCT) articula sistemas setoriais, redes de organizações e estruturas estaduais e municipais de inovação, conduzindo iniciativas voltadas à promoção tecnológica de regiões e localidades, tais como cadeias produtivas, parques tecnológicos e incubadoras de empresas; plataformas tecnológicas e arran...

  14. Deletion mutants of region E1 a of AD12 E1 plasmids: Effect on oncogenic transformation

    NARCIS (Netherlands)

    Bos, J.L.; Jochemsen, A.G.; Bernards, R.A.; Schrier, P.I.; Ormondt, H. van; Eb, A.J. van der

    1983-01-01

    Plasmids containing the El region of Ad12 DNA can transform certain rodent cells into oncogenic cells. To study the role of the Ela subregion in the process of oncogenic transformation, Ad12 region El mutants carrying deletions in the Ela region were constructed. Deletion mutants pR7 and pR8 affect

  15. Expression of I-A and I-E,C region-coded Ia antigens on functional B cell subpopulations.

    Science.gov (United States)

    Frelinger, J A; Hibbler, F J; Hill, S W

    1978-12-01

    Ia antigens from specific subregions have been examined on functional B cell populations. Expression of both I-A and I-E,C region antigens was demonstrated on cells required for both lipopolysaccharide mitogenesis and polyclonal activation. Similar I-A and I-E,C subregion expression was found on cells required for response to the T-independent antigen, polyvinylpyrrolidone. TNP-specific IgM and hen egg lysozyme-specific IgG plaque-forming cells also express I-A and I-E,C region antigens. No evidence was found for an Ia- population responsive in the systems tested. Further, no evidence of preferential expression of I-A or I-E,C region antigens was observed in any system examined. Therefore, it appears that B cells express both I-A and I-E,C region-coded Ia antigens.

  16. Expression of human TNF-related apoptosis-inducing ligand extracellular region in E.coli

    Institute of Scientific and Technical Information of China (English)

    唐蓓; HE; Fengtian; 等

    2002-01-01

    This study is conducted to clone the cDNA encoding human TNF-related apoptosis-inducing ligand(hTRAIL)extracellular region(amino acids 41-281,hTRAIL41-281)and to express it in E.coli.The hTRAIL41-281 cDNA is amplified by reverse transcription(RT)PCR from total RNA derived from human acute promyelocytic leukemia cell line HL-60.After sequenced,the cDNA is cloned into the vector pQE-80L and transformed into E.coli DH5α to express the recombinant hTRAIL41-281(rhTRAIL41-281)induced by IPTG.The recombinant protein is analyzed by SDS-PAGE.The cloned cDNA is consistent with the cDNA sequence encoding hTRAIL41-281 reported in GenBankTM.After inducing.the hTRAIL41-281 protein is expressed,and the mass of the recombinant protein is about 30% of total bacteria protein,which demonstrates that the cDNA encoding hTRAIL41-281 is successfully cloned and expressed in E.coli.

  17. Hepatitis E in a region of Italy: An emerging autochthonous infection?

    Science.gov (United States)

    Tarantino, Giuseppe; Bagnarelli, Patrizia; Marzioni, Marco; Marinelli, Katia; Surace, Giulia; Traini, Sara; Baroni, Gianluca Svegliati; Menzo, Stefano; Benedetti, Antonio

    2016-11-01

    Recent data showed an increasing number of "autochthonous" cases of hepatitis E in Italy. Analysing cases of acute hepatitis E to define frequency, clinical features, prognosis and risk factors. We considered all the patients admitted to our Regional Hospital between August 2011 and September 2014, with a diagnosis of acute hepatitis; serological screening for hepatitis B, C and A viruses was performed; in the event of negative results, sera were tested for cytomegalovirus, Epstein-Barr and hepatitis E viruses. Among 200 patients, 66 were affected by viral infection. IgM anti-HEV was detected in 14 patients with a predominance of males (79%) with a mean age of 55. Genotype 3 of HEV was found in 8 patients. Only one patient died of acute on chronic liver failure; all others evolved favourably towards clinical remission within two months from clinical onset. Thirteen patients had had local exposure to infection and 9 reported the consumption of raw or undercooked locally produced pork. The incidence of HEV in our cohort of patients with acute viral hepatitis is high (about 20% per year). In over 85% an autochthonous exposure to infection could be recognised, with a clear link with food habits. Copyright © 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  18. Il SIT della Regione Puglia, uno strumento a beneficio dei comuni e degli enti locali della Regione

    Directory of Open Access Journals (Sweden)

    Valeria De Vecchi

    2009-03-01

    Full Text Available Puglia region's GIS: a tool in behalf of local public organizationsInnovaPuglia, together with ESRI Italia and Sinergis as technological partners, set up a Geographic Information Systemfor the italian Puglia region. It will help this public organization to better plan and manage the land and the environment of that part of Italy. The possibility to share land informations is one of the mail features of the system: this will be extremely helpful for the government activities and to fullfill land knowledge with precise and homogeneous data.

  19. Retornos da educação e o desequilíbrio regional no Brasil

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Manso

    2010-06-01

    Full Text Available O problema do desequilíbrio regional brasileiro normalmente tem sido tratado na literatura nacional a partir de investigações que utilizam a renda e/ou PIB per capita como variáveis de análise. Para sociedades com baixos níveis de desigualdade, esse procedimento é uma boa representação do bem-estar social. Entretanto, para economias com elevados níveis de pobreza e desigualdade, a utilização da renda ou PIB pode não ser apropriada. Nesse sentido, esse artigo discute se a aproximação da renda per capita existente entre o Nordeste e o Sudeste brasileiro também vem ocorrendo em termos de bem-estar social. Para esse objetivo, duas medidas de bem-estar social são utilizadas: Sen (1977 e Kakwani e Son (2008. Os resultados apontam que, assim como ocorre com a renda per capita, também está havendo aproximação de bemestar considerando a medida de Sen. Entretanto, quando se leva em conta o movimento da renda dos mais pobres, presente no segundo índice, constata-se um afastamento entre as duas regiões. As análises são feitas para o período de 1995 a 2007. Por fim, identificou-se que foram os ganhos de produtividade dos trabalhadores pertencentes a famílias pobres no Sudeste os principais responsáveis por esse distanciamento.The problem of Brazilian regional disequilibrium has usually been treated in the national literature from investigations using income and/or GDP percapita as a variable of analysis. For communities with low levels of inequality, this procedure is a good representation of the social welfare. However, for economies with high levels of poverty and inequality, the use of income or GDP cannot be appropriate. Accordingly, this article discusses if the approximation of per capita income between the Northeast and Southeast Brazil has also occurred in terms of social welfare. To this, two measures of social welfare are used: Sen (1977 and Kakwani e Son (2008. The results suggest as occurs with per capita income, there

  20. Interoperabilità e accessibilità dei dati topografici. Integrazione, aggiornamento e generalizzazione delle banche dati della Regione Toscana

    Directory of Open Access Journals (Sweden)

    Christian Ciampi

    2015-10-01

    Full Text Available The Project that involves the Italian Institute “Centro Interuniversitario di Scienze del Territorio” and the Italian Regional Institution “Regione Toscana” is the background of the presented research that was activated to verify the potential use of Desktop GIS computer tools in map generalization. The large scale topographic map data stored in the Regional Database was processed using map generalization models and tools to create a small scale map useful to support landscape analysis and studies.

  1. Measurement of Atomic Oxygen in Diffuse Aurora and Ion Density in the E-Region

    Science.gov (United States)

    Sharp, William E.

    1997-01-01

    An ion mass spectrometer (IMS) was refurbished, calibrated and supplied to the University of Colorado payload (Dr. Charles Barth, P.I.) which was launched from White Sands in September of 1993 as NASA 33.062. The nose cone failed to deploy and their were problems with the ACS so the mission was declared a failure. However, the door covering the IMS deployed and the instrument obtained data. The launch occurred shortly after a payload carrying solar x-ray detectors was launched. Thus a small portion of the Colorado payload science was salvaged; namely, the NO(+)/O2(+) ratio to compare with the measured x-ray flux. Figure I shows the NO(+) to O2(+) ratio vs. altitude. The behavior is typical of the E-region.

  2. Politics in the Western Maya Region (I: Ajawil/Ajawlel and Ch'e'n

    Directory of Open Access Journals (Sweden)

    Péter Bíró

    2011-01-01

    Full Text Available In a series of articles I reflect on the use of various expressions which are connected to what we call the political in the inscriptions of the Classic Maya Western Region. These words express concepts which help to understand the intricate details of the interactions between the political entities and their internal organisations in the Classic Maya Lowlands. Words such as 7ajawil, 7ajawlel, the kennings built on the base of ch'e7n (cave, pond, the emblem glyphs and titles will be examined in light of what they tell us about the functioning of the political organisation of the Classic Period in a constrained region.En una serie de artículos como éste investigo el uso de varias palabras en las inscripciones mayas de la época Clásica de la Región Occidental vinculadas con lo que nosotros llamamos "política". Estas palabras expresan conceptos que ayudan a entender los matices de las relaciones entre las entidades políticas de las Tierras Bajas Mayas y su organización interna. Términos como ajaw'ü I ajawlel, los difrasismos con base ch'e'n (cueva, pozo, los glifos emblemas y los títulos serán examinados tomando en cuenta la información que nos proporcionan sobre el funcionamiento de la organización política de la época Clásica en una región restringida.

  3. Stochastic Lagrangian dynamics for charged flows in the E-F regions of ionosphere

    Science.gov (United States)

    Tang, Wenbo; Mahalov, Alex

    2013-03-01

    We develop a three-dimensional numerical model for the E-F region ionosphere and study the Lagrangian dynamics for plasma flows in this region. Our interest rests on the charge-neutral interactions and the statistics associated with stochastic Lagrangian motion. In particular, we examine the organizing mixing patterns for plasma flows due to polarized gravity wave excitations in the neutral field, using Lagrangian coherent structures (LCS). LCS objectively depict the flow topology—the extracted attractors indicate generation of ionospheric density gradients, due to accumulation of plasma. Using Lagrangian measures such as the finite-time Lyapunov exponents, we locate the Lagrangian skeletons for mixing in plasma, hence where charged fronts are expected to appear. With polarized neutral wind, we find that the corresponding plasma velocity is also polarized. Moreover, the polarized velocity alone, coupled with stochastic Lagrangian motion, may give rise to polarized density fronts in plasma. Statistics of these trajectories indicate high level of non-Gaussianity. This includes clear signatures of variance, skewness, and kurtosis of displacements taking polarized structures aligned with the gravity waves, and being anisotropic.

  4. Southern high-latitude Digisonde observations of ionosphere E-region Bragg scatter during intense lacuna conditions

    Directory of Open Access Journals (Sweden)

    D. P. Monselesan

    2004-09-01

    Full Text Available During summer months at solar cycle minimum, F-region lacuna and slant-Es conditions (SEC are common features of daytime ionograms recorded around local magnetic noon at Casey, Antarctica. Digisonde measurements of drift velocity height profiles show that the occurrence of lacuna prevents the determination of F-region drift velocities and also affects E-region drift velocity measurements. Unique E-region spectral features revealed as intervals of Bragg scatter superimposed on typical background E-region reflection were observed in Digisonde Doppler spectra during intense lacuna conditions. Daytime E-region Doppler spectra recorded at carrier frequencies from 1.5 to 2.7MHz, below the E-region critical frequency foE, have two side-peaks corresponding to Bragg scatter at approximately ±1-2Hz symmetrically located on each side of a central-peak corresponding to near-zenith total reflections. Angle-of-arrival information and ray-tracing simulations show that echo returns are coming from oblique directions most likely resulting from direct backscatter from just below the total reflection height for each sounding frequency. The Bragg backscatter events are shown to manifest during polar lacuna conditions, and to affect the determination of E-region background drift velocities, and as such must be considered when using standard Doppler-sorted interferometry (DSI techniques to estimate ionospheric drift velocities. Given the Doppler and spatial separation of the echoes determined from high-resolution Doppler measurements, we are able to estimate the Bragg scatter phase velocity independently from the bulk E-region motion. The phase velocity coincides with the ExB direction derived from in situ fluxgate magnetometer records. When ionospheric refraction is considered, the phase velocity amplitudes deduced from DSI are comparable to the ion-acoustic speed expected in the E-region. We briefly consider the plausibility that these

  5. Morbidade Materna Grave e Near Misses em Hospital de Referência Regional

    Directory of Open Access Journals (Sweden)

    Márcia Lait Morse

    2011-06-01

    Full Text Available OBJETIVO: Analisar perfil epidemiológico da morbidade materna grave/near miss em uma maternidade pública de referência regional, utilizando diferentes critérios identificadores. MÉTODOS: Trata-se de um estudo descritivo de corte transversal dos casos de morbidade materna grave/near miss realizado em Hospital de referência regional entre junho e outubro de 2009, identificados a partir dos livros de registro de internação da maternidade e análise dos prontuários clínicos. Foram estudadas mulheres que, durante a gestação, parto ou puerpério, apresentaram qualquer quadro clínico compatível com os critérios definidores de morbidade materna grave/near miss de Waterstone et al., Mantel et al. e Organização Mundial de Saúde. RESULTADOS: Entre as 1.544 internações foram identificadas 89 mulheres com morbidade materna grave, considerando os critérios adotados. As razões de morbidade materna grave/near miss variaram entre 81,4 a 9,4 por 1.000 NV, dependendo do critério utilizado. O índice de Mortalidade foi de 3,2%, chegando a 23% no critério da OMS. Das 89 mulheres, apenas 40% fizeram mais de seis consultas de pré-natal e 10% não realizaram qualquer consulta. Os marcadores mais encontrados foram a pré-eclâmpsia grave seguida de hemorragia grave, internação em UTI, Síndrome HELLP e eclâmpsia. Ocorreram três mortes maternas por causas obstétricas com RMM de 280/100.000 NV e uma morte tardia. O critério da OMS se mostrou mais específico, identificando os casos mais graves, enquanto o de Waterstone foi mais sensível. CONCLUSÃO: O estudo da morbidade materna grave/near miss em um hospital de referência regional pode contribuir para o conhecimento da magnitude deste evento, como também identificar suas características e condições clínicas mais frequentes, sendo extremamente importante para o enfrentamento da morbi-mortalidade materna.OBJECTIVE: To investigate severe maternal morbidity/near misses in a tertiary

  6. Migraciones e interacción regional en Colombia, 1973-1993

    Directory of Open Access Journals (Sweden)

    Samuel Jaramillo

    1999-01-01

    Full Text Available El artículo se propone hacer una lectura de la información censal sobre migración poblacional como indicador de las pautas de interacción socioespacial en el territorio colombiano., algo novedoso, pues en nuestro medio son muy raros los estudios socioespaciales que se apoyen en evidencias de flujos e interacción. Para ello se examinan las cifras de “migración de toda la vida” de los censos de 1973 y 1993 y se intenta discernir algunas tendencias durante este período. La primera parte del artículo examina el comportamiento de la migración entre las cuatro grandes regiones socio-culturales que han sido constitutivas de la estructura socioespacial colombiana en el largo plazo (con la adición de una quinta región de expansión de la frontera socioeconómica, con el fin de tener alguna idea sobre la trayectoria reciente de unificación del territorio. La segunda parte analiza la interacción entre los departamentos y se construye un esuema de jerarquización e interacción socioespacial en cada una de las dos fechas.

  7. A three dimensional study of E region irregularity patches in the equatorial anomaly region using the Chung-Li VHF radar

    Energy Technology Data Exchange (ETDEWEB)

    Pan, C.J.; Liu, C.H.; Su, S.Y. [National Central Univ., Taiwan (China); Roettger, J. [EISCAT Scientific Association, Kiruna (Sweden)

    1994-08-15

    The authors report on VHF radar observations of E region Field Aligned Irregularity patches made from Taiwan. They observe pancake shaped patches, smaller than the radar viewing width. They are seen at heights above 100 km, drifting with velocities slightly less than 100 m/s.

  8. Cross section line shape of $e^+e^-\\to\\chi_{c0}\\omega$ around the $Y(4260)$ mass region

    CERN Document Server

    Cleven, Martin

    2016-01-01

    We demonstrate that the recent measurement of the cross section line shapes of $e^+e^-\\to \\chi_{c0}\\omega$ can be naturally explained by the molecular picture for $Y(4260)$ where the $Y(4260)$ is treated as a hadronic molecule dominated by $\\bar{D}D_1(2420)+c.c.$ This result is consistent with properties extracted for $Y(4260)$ as the $\\bar{D}D_1(2420)+c.c.$ molecular state in other reactions such as $e^+e^-\\to J/\\psi\\pi\\pi$, $h_c\\pi\\pi$, $\\bar D D^*\\pi +c.c.$, and $\\gamma X(3872)$.

  9. MatSeis and the GNEM R&E regional seismic anaylsis tools.

    Energy Technology Data Exchange (ETDEWEB)

    Chael, Eric Paul; Hart, Darren M.; Young, Christopher John; Merchant, Bion John

    2003-08-01

    To improve the nuclear event monitoring capability of the U.S., the NNSA Ground-based Nuclear Explosion Monitoring Research & Engineering (GNEM R&E) program has been developing a collection of products known as the Knowledge Base (KB). Though much of the focus for the KB has been on the development of calibration data, we have also developed numerous software tools for various purposes. The Matlab-based MatSeis package and the associated suite of regional seismic analysis tools were developed to aid in the testing and evaluation of some Knowledge Base products for which existing applications were either not available or ill-suited. This presentation will provide brief overviews of MatSeis and each of the tools, emphasizing features added in the last year. MatSeis was begun in 1996 and is now a fairly mature product. It is a highly flexible seismic analysis package that provides interfaces to read data from either flatfiles or an Oracle database. All of the standard seismic analysis tasks are supported (e.g. filtering, 3 component rotation, phase picking, event location, magnitude calculation), as well as a variety of array processing algorithms (beaming, FK, coherency analysis, vespagrams). The simplicity of Matlab coding and the tremendous number of available functions make MatSeis/Matlab an ideal environment for developing new monitoring research tools (see the regional seismic analysis tools below). New MatSeis features include: addition of evid information to events in MatSeis, options to screen picks by author, input and output of origerr information, improved performance in reading flatfiles, improved speed in FK calculations, and significant improvements to Measure Tool (filtering, multiple phase display), Free Plot (filtering, phase display and alignment), Mag Tool (maximum likelihood options), and Infra Tool (improved calculation speed, display of an F statistic stream). Work on the regional seismic analysis tools (CodaMag, EventID, PhaseMatch, and Dendro

  10. Regionalism, Regionalization and Regional Development

    Directory of Open Access Journals (Sweden)

    Liviu C. Andrei

    2016-03-01

    Full Text Available Sustained development is a concept associating other concepts, in its turn, in the EU practice, e.g. regionalism, regionalizing and afferent policies, here including structural policies. This below text, dedicated to integration concepts, will limit on the other hand to regionalizing, otherwise an aspect typical to Europe and to the EU. On the other hand, two aspects come up to strengthen this field of ideas, i.e. the region (al-regionalism-(regional development triplet has either its own history or precise individual outline of terms.

  11. CUTLASS HF radar observations of high-velocity E-region echoes

    Directory of Open Access Journals (Sweden)

    M. V. Uspensky

    Full Text Available A short event of high-velocity E-region echo observations by the Pykkvibaer HF radar is analysed to study echo parameters and the echo relation to the Farley-Buneman plasma instability. The echoes were detected in several beams aligned closely to the magnetic L-shell direction. Two echo groups were identified: one group corresponded to the classical type 1 echoes with velocities close to the nominal ion-acoustic speed of 400 ms1 , while the other group had significantly larger velocities, of the order of 700 ms1 . The mutual relationship between the echo power, Doppler velocity, spectral width and elevation angles for these two groups was studied. Plotting of echo parameters versus slant range showed that all ~700 ms1 echoes originated from larger heights and distances of 500–700 km, while all ~400 ms1 echoes came from lower heights and from farther distances; 700–1000 km. We argue that both observed groups of echoes occurred due to the Farley-Buneman plasma instability excited by strong ( ~70 mVm1 and uniformly distributed electric fields. We show that the echo velocities for the two groups were different because the echoes were received from different heights. Such a separation of echo heights occurred due to the differing amounts of ionospheric refraction at short and large ranges. Thus, the ionospheric refraction and related altitude modulation of ionospheric parameters are the most important factors to consider, when various characteristics of E-region decametre irregularities are derived from HF radar measurements.

    Key words. Ionosphere (ionospheric irregularities; plasma waves and instabilities; polar ionosphere

  12. The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif

    Directory of Open Access Journals (Sweden)

    Grishin Nick V

    2009-01-01

    Full Text Available Abstract Background Argonaute (Ago proteins interact with small regulatory RNAs to mediate gene regulatory pathways. A recent report by Kiriakidou et al. 1 describes an MC sequence region identified in Ago2 that displays similarity to the cap-binding motif in translation initiation factor 4E (eIF4E. In a cap-bound eIF4E structure, two important aromatic residues of the motif stack on either side of a 7-methylguanosine 5'-triphosphate (m7Gppp base. The corresponding Ago2 aromatic residues (F450 and F505 were hypothesized to perform the same cap-binding function. However, the detected similarity between the MC sequence and the eIF4E cap-binding motif was questionable. Results A number of sequence-based and structure-based bioinformatics methods reveal the reported similarity between the Ago2 MC sequence region and the eIF4E cap-binding motif to be spurious. Alternatively, the MC sequence region is confidently assigned to the N-terminus of the Ago piwi module, within the mid domain of experimentally determined prokaryotic Ago structures. Confident mapping of the Ago2 MC sequence region to the piwi mid domain results in a homology-based structure model that positions the identified aromatic residues over 20 Å apart, with one of the aromatic side chains (F450 contributing instead to the hydrophobic core of the domain. Conclusion Correct functional prediction based on weak sequence similarity requires substantial evolutionary and structural support. The evolutionary context of the Ago mid domain suggested by multiple sequence alignment is limited to a conserved hydrophobicity profile required for the fold and a motif following the MC region that binds guide RNA. Mapping of the MC sequence to the mid domain structure reveals Ago2 aromatics that are incompatible with eIF4E-like mRNA cap-binding, yet display some limited local structure similarities that cause the chance sequence match to eIF4E. Reviewers This article was reviewed by Arcady Mushegian

  13. Reflectance-difference study near the E{sub 1} and E{sub 1} + {delta}{sub 1} transition regions of CdTe

    Energy Technology Data Exchange (ETDEWEB)

    Molina C, J Rafael [Centro de Investigaciones en Optica, AC, Loma del Bosque 115, Colonia Lomas del Campestre, CP 37150 Leon, Guanajuato (Mexico); Espinosa-Luna, Rafael [Centro de Investigaciones en Optica, AC, Loma del Bosque 115, Colonia Lomas del Campestre, CP 37150 Leon, Guanajuato (Mexico)

    2005-01-07

    We report on a study of the experimental reflectance-difference (RD) line shape for CdTe near the E{sub 1} and E{sub 1} + {delta}{sub 1} spectral regions. A clear reflectivity component, as a major contribution near the E{sub 1} and E{sub 1} + {delta}{sub 1} spectral regions, to the measured RD CdTe line shape is found. No derivative-like, {epsilon} -like or 1/{epsilon} -like line shapes are observed for our sample. Results suggest that the experimental RD spectra cannot be explained by considering an anisotropic film on the surface of the material nor by a dislocation-induced piezo-optic effect.

  14. On the Dependence of the Ionospheric E-Region Electric Field of the Solar Activity

    Science.gov (United States)

    Denardini, Clezio Marcos; Schuch, Nelson Jorge; Moro, Juliano; Araujo Resende, Laysa Cristina; Chen, Sony Su; Costa, D. Joaquim

    2016-07-01

    We have being studying the zonal and vertical E region electric field components inferred from the Doppler shifts of type 2 echoes (gradient drift irregularities) detected with the 50 MHz backscatter coherent (RESCO) radar set at Sao Luis, Brazil (SLZ, 2.3° S, 44.2° W) during the solar cycle 24. In this report we present the dependence of the vertical and zonal components of this electric field with the solar activity, based on the solar flux F10.7. For this study we consider the geomagnetically quiet days only (Kp <= 3+). A magnetic field-aligned-integrated conductivity model was developed for proving the conductivities, using the IRI-2007, the MISIS-2000 and the IGRF-11 models as input parameters for ionosphere, neutral atmosphere and Earth magnetic field, respectively. The ion-neutron collision frequencies of all the species are combined through the momentum transfer collision frequency equation. The mean zonal component of the electric field, which normally ranged from 0.19 to 0.35 mV/m between the 8 and 18 h (LT) in the Brazilian sector, show a small dependency with the solar activity. Whereas, the mean vertical component of the electric field, which normally ranges from 4.65 to 10.12 mV/m, highlight the more pronounced dependency of the solar flux.

  15. Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice.

    Science.gov (United States)

    Lattanzio, F; Carboni, L; Carretta, D; Rimondini, R; Candeletti, S; Romualdi, P

    2014-01-01

    The apolipoprotein E4 (apoE4) allele is consistently associated with increased risk for Alzheimer's disease (AD). We investigated the molecular mechanism of this susceptibility by analyzing the levels of genes involved in AD pathogenesis in transgenic mice expressing human apoE3 or apoE4 isoforms. mRNA and protein levels of Pin1, Sirtuin 1 (Sirt1), Presenilin 1 (PS1), and pro-Brain-derived Neurotrophic Factor (BDNF) were analyzed in brain regions affected by neuropathological changes in AD. Pin1 mRNA was significantly higher in the hippocampus of apoE4 mice than in apoE3 controls, whereas lower expression was detected in the entorhinal and parietal cortices. Reduced Pin1 levels may increase neurofibrillary degeneration and amyloidogenic processes, while compensatory mechanisms may take place in the hippocampus to balance spatial memory deficits. Sirt1 levels were significantly reduced in the frontal cortex of apoE4 mice. Sirt1 reduction may hinder its protective role against the formation of plaques and tangles and diminish its anti-inflammatory actions. Sirt1 decrease may also play a role in apoE4-associated memory impairments. Moreover, in apoE4 mice PS1 mRNA levels were lower in the frontal cortex. Lower PS1 expression may hamper γ-secretase function, thus affecting amyloid precursor protein processing. Pro-BDNF mRNA levels did not differ between apoE3 and apoE4 mice in any region analyzed. This study showed dysregulated expression of Pin1, Sirt1, and PS1 genes in different cerebral areas of apoE4 mice, suggesting that these changes may play a role in the mechanism of AD vulnerability.

  16. INFLUÊNCIA DA COMPOSIÇÃO CORPORAL REGIONAL E TOTAL SOBRE O DESEMPENHO DE NADO E ÍNDICES AERÓBIOS

    Directory of Open Access Journals (Sweden)

    Dalton Müller Pessôa Filho

    Full Text Available RESUMO Introdução: Poucos estudos analisaram a contribuição da composição regional de nadadores para o perfil aeróbio, anaeróbio e o desempenho de nado. Objetivo: Verificar a influência da composição corporal regional e total sobre índices da aptidão aeróbia e anaeróbia em nado atado e livre, bem como sobre o desempenho de curta e média duração. Métodos: Onze nadadores (18,0 ± 4,0 anos foram submetidos a: (1 teste incremental em nado atado, com coleta de gases respiração-a-respiração (K4b2 associado ao novo-AquaTrainerâ; e (2 tempo limite nos desempenhos de 200, 400 e 800 metros de nado livre. A regressão linear entre distância e tempo (d-tLim empregou o método dos quadrados mínimos. O coeficiente de Pearson (r averiguou as correlações da composição corporal regional e total com índices da aptidão aeróbica e anaeróbica em nado atado e livre. Resultados: Os valores da massa isenta de gordura (MIG foram: 61,7 ± 7,4 kg; 7,5 ± 1,1 kg; 28,3 ± 3,7 kg; 22,1 ± 2,5 kg, respectivamente para corpo todo, membros superiores (MS, tronco (T e membros inferiores (MI. O consumo máximo de oxigênio (VO2max foi 52,1 ± 5,3 ml×kg-1×min-1, sendo a carga correspondente (iVO2max de 93,9 ± 12,2 N. O tempo em 200 (132,2 ± 9,7 s, 400 (296,8 ± 17,2 s e 800 metros (619,5 ± 26,9 s forneceu velocidade crítica (VC = 1,23 ± 0,06 m×s-1 e capacidade anaeróbica de nado (CNA = 35,8 ± 15,1 m. Observaram-se correlações de iVO2max, CAN e v200m com MIG para MS (r = 0,64; 0,67 e 0,76, porém a MIG para T, MI e corporal demonstraram correlações apenas com v200m (r = 0,75; 0,69 e 0,75 e CAN (r = 0,71; 0,69 e 0,75. Conclusão: Houve, portanto, influência da MIG regional e corporal sobre o desempenho de curta distância e reservas anaeróbias, sendo a MIG-MS também influente sobre a iVO2max, e assim relacionada ao aprimoramento do desempenho de nado.

  17. Loop structures in the 5' untranslated region and antisense RNA mediate pilE gene expression in Neisseria gonorrhoeae.

    Science.gov (United States)

    Masters, Thao L; Wachter, Jenny; Hill, Stuart A

    2016-11-01

    Regulation of the Neisseria gonorrhoeae pilE gene is ill-defined. In this study, post-transcriptional effects on expression were assessed. In silico analysis predicts the formation of three putative stable stem-loop structures with favourable free energies within the 5' untranslated region of the pilE message. Using quantitative reverse transcriptase PCR analyses, we show that each loop structure forms, with introduced destabilizing stem-loop mutations diminishing loop stability. Utilizing a series of pilE translational fusions, deletion of either loop 1 or loop 2 caused a significant reduction of pilE mRNA resulting in reduced expression of the reporter gene. Consequently, the formation of the loops apparently protects the pilE transcript from degradation. Putative loop 3 contains the pilE ribosomal binding site. Consequently, its formation may influence translation. Analysis of a small RNA transcriptome revealed an antisense RNA being produced upstream of the pilE promoter that is predicted to hybridize across the 5' untranslated region loops. Insertional mutants were created where the antisense RNA is not transcribed. In these mutants, pilE transcript levels are greatly diminished, with any residual message apparently not being translated. Complementation of these insertion mutants in trans with the antisense RNA gene facilitates pilE translation yielding a pilus + phenotype. Overall, this study demonstrates a complex relationship between loop-dependent transcript protection and antisense RNA in modulating pilE expression levels.

  18. Characteristics of low latitude ionospheric E-region irregularities linked with daytime VHF scintillations measured from Varanasi

    Indian Academy of Sciences (India)

    K Patel; A K Singh; R P Patel; R P Singh

    2009-12-01

    VHF amplitude scintillations recorded during the daytime period from January 1991 to December 1993, April 1998 to December 1999 and January 2008 to December 2008 at low latitude station Varanasi (geographic lat. = 25° 15′N; long. = 82° 59′E; geomagnetic lat. = 14° 55′N, long. = 154°E, dip angle = 37.3°, sub-ionospheric dip = 34°) have been analyzed to study the behaviour of ionospheric E-region irregularities during the active solar and magnetic periods. The autocorrelation functions, power spectral densities, signal de-correlation times are computed to study the temporal features of ionospheric E-region irregularities linked with daytime scintillations. Derived spectral index ranges between −2 and −9. Assuming velocity of irregularities, the characteristic lengths of the E-region irregularities are estimated. We have estimated the minimum and maximum range of scale length of sporadic-E () irregularities to be observed over Varanasi. These results are in close agreement with those reported from this latitude region.

  19. Mapping of IgE-binding regions on recombinant Cyn d 1, a major allergen from Bermuda Grass Pollen (BGP

    Directory of Open Access Journals (Sweden)

    Bhalla Prem L

    2009-02-01

    Full Text Available Abstract Background Bermuda grass (Cynodon dactylon; subfamily Chloridoideae is an important source of seasonal aeroallergens in warm tropical and sub-tropical areas worldwide. Improved approaches to diagnosis and therapy of allergic diseases require a thorough understanding of the structure and epitopes on the allergen molecule that are crucial for the antigen-antibody interaction. This study describes the localization of the human IgE-binding regions of the major group 1 pollen allergen Cyn d 1 from Bermuda grass. Methods A cDNA library was constructed from Bermuda grass pollen (BGP using a Lambda gt11 expression vector. The gene encoding the Cyn d 1 allergen was isolated by screening the library with a mouse monoclonal antibody raised against grass group 1 allergen. In order to characterize the IgE epitopes on Cyn d 1, seven overlapping fragments and three deletion mutants were cloned and over-expressed in E. coli. The recombinant fragments and deletion mutants were evaluated for their comparative IgE reactivity with sera of non atopic individuals and grass pollen allergic patients by ELISA and a dot-blot assay. Results Analysis of IgE binding regions by overlapping fragments and deletion mutants identified two major allergenic regions corresponding to amino acids 120–170 and 224–244. Deletion of either or both regions led to a significant reduction in IgE binding, emphasizing the importance of the C-terminal region on Cyn d 1 in epitope-IgE interaction. Conclusion Anti-Cyn d 1 IgE antibodies from allergic human sera recognize two epitopes located at the C-terminal end of the molecule. These data will enable the design of improved diagnostic and therapeutic approaches for BGP hypersensitivity.

  20. [Human papillomavirus type 16 variant analysis of upstream regulatory region and E6, E7 oncogene from cervical cancer patients in Beijing].

    Science.gov (United States)

    Xiong, Guang-Wu; Yuan, Yang; Li, Meng; Guo, Hong-Yan; Zhang, Xiao-Wei

    2010-04-01

    To investigate distributional characteristics of mutations of HPV16 upstream regulatory region (URR) and E6 and E7 oncogene in the patients with cervical cancer in Beijing and to explore the potential association between oncogenesis of cervical cancer and HPV variants in this region, cervical cancer tissue from 31 cases with positive HPV16 were subjected to regular DNA extraction procedure. The corresponding primers were then designed to amplify the target sequence of URR, E6 and E7. The PCR products were sequenced and blast analysis against GenBank was carried out to evaluate the gene mutation and identify the phylogenetic branches. Among all the cases studied, URR was found to be the most frequent mutation fragments, followed by E7, and E6 was the most conservative sequence. A total of 8 hot mutation spot was identi-fied, which were URR G7521A (100%), C7435G (96.77%), C24T (45.16%), A7729C (45.16%), G7839A (45.16%), E6 T178G (41.94%), E7 A647G (45.16%), and T846C (45.16%). The most frequent HPV 16 branch was type As (54.84%), followed by type E (45.16%). Our results suggested that the mutations of G7521A, A7729C, G7839A, T178G, T350G, A647G, and G658A were likely to be associated with the enhanced oncogenic potential of HPV16 and oncogenesis of cer-vical cancer. In Beijing area, two major branches of HPV16 were type As and E. This finding provides valuable information for HPV vaccine development and infection treatment. Type As and E variants had different distributions among various ages and clinic stage groups. It might lead to a new explanation for the getting younger trend of cervical cancer.

  1. PRODUÇÃO DE ALIMENTOS TRADICIONAIS Contribuindo para o desenvolvimento local/regional e dos pequenos produtores rurais

    OpenAIRE

    Zuin, Luís Fernando Soares; Zuin, Poliana Bruno

    2008-01-01

    Esse artigo tem como finalidade apresentar uma proposta de produção para o desenvolvimento de alimentos tradicionais, baseada no modelo de Processo e Desenvolvimentos de Produtos Rurais (PDP-rural), proposto por Zuin e Alliprandini (2006). Essa proposta objetiva contribuir com os pequenos produtores rurais e com o desenvolvimento local e regional, por meio da agregação de valor aos produtos do tipo commodities. Mas o que são os alimentos tradicionais? São os alimentos chamados, também, de pro...

  2. Regional cooling for reducing brain temperature and intracranial pressure Resfriamento cerebral regional para redução da temperatura e pressão intracraniana

    Directory of Open Access Journals (Sweden)

    Luis Vicente Forte

    2009-06-01

    Full Text Available OBJECTIVE: To evaluate the effectiveness of regional cooling for reducing brain temperature (BrTe and intracranial pressure (ICP in patients where conventional clinical treatment has failed. METHOD: Regional cooling was carried out using ice bags covering the area of the craniectomy (regional method in 23 patients. The BrTe and ICP were determined using a fiber optic sensor. Thirteen patients (56.52% were female. The ages ranged from 16 to 83 years (mean of 48.9. The mean APACHE II score was 25 points (11-35. The patients were submitted, on mean, to 61.7 hours (20-96 of regional cooling. RESULTS: There was a significant reduction in mean BrTe (pOBJETIVO: Avaliar a eficácia do resfriamento regional na redução da temperatura cerebral (TeCe e pressão intracraniana (PIC após falha das medidas clínicas convencionais de tratamento. MÉTODO: O resfriamento cerebral foi realizado com bolsas com gelo, colocadas sobre a área de craniectomia (método regional em 23 doentes. A TeCe e PIC foram verificadas com sensor de fibra óptica. Treze (56,52% eram do sexo feminino. A idade variou de 16 a 83 anos (média 48,96. A pontuação média no índice APACHE II foi 25 pontos (11-35. Os doentes foram submetidos, em média, a 61,7 horas (20-96 de resfriamento regional. RESULTADOS: Houve uma redução significativa da TeCe média (p<0,0001-de 37,1ºC para 35,2ºC e da PIC média (p=0,0001-de 28 mmHg para 13 mmHg. CONCLUSÃO: Nossos resultados sugerem que o resfriamento regional foi eficaz no controle da PIC nos doentes submetidos, previamente, a craniectomia descompressiva.

  3. A integração regional e a coexistência entre ALCA, MERCOSUL e comunidade andina

    Directory of Open Access Journals (Sweden)

    Sergio Eduardo Canella

    2004-12-01

    Full Text Available The objective in this work is to verify the possibility of coexistence between the FTAA, MERCOSUL and Andean Community.O objetivo neste trabalho é verificar a possibilidade de coexistência entre a ALCA, MERCOSUL e Comunidade Andina.

  4. Impact of plasma sheath on rocket-based E-region ion measurements

    Science.gov (United States)

    Imtiaz, Nadia; Burchill, Johnathan; Marchand, Richard

    2015-01-01

    We model the particle velocity distribution functions around the entrance window of the Suprathermal Ion Imager (SII). The SII sensor was mounted on a 1 m boom carried by the scientific payload of NASA rocket 36.234 as part of Joule II mission to investigate Joule heating in the E-region ionosphere. The rocket flew above Northern Alaska on 19 January 2007. The payload was spin-stabilized with a period of 1.6 s, giving an apparent rotation of the ion flow velocity in the frame of reference of the payload. The SII sensor is an electrostatic analyzer that measures two dimensional slices of the distribution of the kinetic energies and arrival-angles of low energy ions. The study is concerned with the interpretation of data obtained from the SII sensor. For this purpose, we numerically investigate ram velocity effects on ions velocity distributions in the vicinity of the SII sensor aperture at an altitudes of approximately 150 km. The electrostatic sheath profiles surrounding the SII sensor, boom and payload are calculated numerically with the PIC code PTetra. It is observed that the direction of the ion flow velocity modifies the plasma sheath potential profile. This in turn impacts the velocity distributions of NO+ and ions at the aperture of the particle sensor. The velocity distribution functions at the sensor aperture are calculated by using test-particle modeling. These particle distribution functions are then used to inject particles in the sensor, and calculate the fluxes on the sensor microchannel plate (MCP), from which comparisons with the measurements can be made.

  5. Piattaforma multimediale e interattiva, per la conoscenza e la salvaguardia del patrimonio Ambientale ed Architettonico in area Mediterranea con particolare riferimento alla regione del Maghreb.

    Directory of Open Access Journals (Sweden)

    Domenico Tosto

    2010-12-01

    Full Text Available La salvaguardia del patrimonio culturale, storico e architettonico occupa un posizione di rilievo all’interno dei diversi campi di applicazione che riguardano la comunicazione globale. La società attuale trova al giorno d’oggi nella comunicazione globale il più importante strumento di informazione. Dall’interazione tra beni culturali e nuove tecnologie, sicuramente, potranno crearsi numerose opportunità a livello conservativo, comunicativo e di sviluppo economico per quello che riguarda il ricchissimo patrimonio storico-artistico presente nel Mediterraneo. Il bacino mediterraneo ed in particolar modo l’area del Maghreb offre un vastissimo repertorio di casi utili per sperimentare metodi di indagine, teorie e tecniche utili per la comprensione, il recupero e la salvaguardia di impianti architettonici di rilevante importanza storico-culturale. Con il termine Maghreb (che in arabo significa “occidente” si identifica l’intera regione dell’Africa settentrionale che comprende Marocco, Algeria, Tunisia, Libia, Egitto.

  6. EISCAT Svalbard radar observations of SPEAR-induced E- and F-region spectral enhancements in the polar cap ionosphere

    Directory of Open Access Journals (Sweden)

    R. S. Dhillon

    2007-08-01

    Full Text Available The Space Plasma Exploration by Active Radar (SPEAR facility has successfully operated in the high-power heater and low-power radar modes and has returned its first results. The high-power results include observations of SPEAR-induced ion and plasma line spectral enhancements recorded by the EISCAT Svalbard UHF incoherent scatter radar system (ESR, which is collocated with SPEAR. These SPEAR-enhanced spectra possess features that are consistent with excitation of both the purely growing mode and the parametric decay instability. In this paper, we present observations of upper and lower E-region SPEAR-induced ion and plasma line enhancements, together with F-region spectral enhancements, which indicate excitation of both instabilities and which are consistent with previous theoretical treatments of instability excitation in sporadic E-layers. In agreement with previous observations, spectra from the lower E-region have the single-peaked form characteristic of collisional plasma. Our observations of the SPEAR-enhanced E-region spectra suggest the presence of variable drifting regions of patchy overdense plasma, which is a finding also consistent with previous results.

  7. Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry

    DEFF Research Database (Denmark)

    Carlsen, Thomas H R; Scheel, Troels K H; Ramirez, Santseharay

    2013-01-01

    The hepatitis C virus (HCV) envelope proteins E1 and E2 play a key role in host cell entry and represent important targets for vaccine and drug development. Here, we characterized HCV recombinants with chimeric E1/E2 complexes in vitro. Using genotype 1a/2a JFH1-based recombinants expressing 1a...... in particle density. In addition, the 1b-E2 exchange led to a decrease in secreted core protein of 25 to 50%, which was further reduced by the E2 stem region mutations. These findings indicated that compensatory mutations permitted robust infectious virus production, without increasing assembly...

  8. Road Safety in Puglia Region La sicurezza stradale in Puglia: stato di fatto e ipotesi di intervento

    Directory of Open Access Journals (Sweden)

    Pierpaolo Bonerba

    2009-07-01

    association towards a safer and sustainable mobility. In addition, the enhancement of technical structures in charge of traffic and safety has been achieved. The expected results concern: – improvement of cooperation between all actors involved; – improvement of a local integrated culture about road safety; – availability of a powerful analysis tool and a Monitoring Centre; – development of some operational plans to improve safety and reduce crashes risks in the most critical points. – report progress in implementing the road safety strategy directed at reducing the number of accidents and casualties; – report the effectiveness of casualty reduction measures. – report on progress with road safety partnerships.L’articolo, partendo da una descrizione delle attività e delle principali funzioni del Centro Regionale di Monitoraggio della Sicurezza Stradale CReMSS della regione Puglia, vuole fornire un quadro sullo stato della sicurezza della rete stradale pugliese. In particolare lo studio vuole evidenziare le criticità e i punti di forza del caso della Puglia, mettendo in evidenza il sistema di interventi messi in atto e programmati. Il CReMSS, istituito con la legge regionale 18/2004, rappresenta uno strumento di raccolta e di analisi dei dati sull’incidentalità al fine di indirizzare le politiche e gli interventi in materia di sicurezza stradale, così come previsto nel Piano Nazionale della Sicurezza Stradale (PNSS legge 144/99. Le azioni del centro sono prevalentemente orientate al coordinamento e al raccordo con altri centri di monitoraggio (comunali, provinciali e nazionali in modo da assicurare un’integrazione delle basi conoscitive e valutative del fenomeno incidentalità viaria e con tutti gli enti, le scuole di ogni ordine grado, e le realtà del privato sociale per diffondere i saperi e condividere le buone pratiche in materia di sicurezza stradale.

  9. Functional analysis of the C-terminal region of human adenovirus E1A reveals a misidentified nuclear localization signal

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Michael J.; King, Cason R.; Dikeakos, Jimmy D. [Department of Microbiology and Immunology, The University of Western Ontario, A4-833 London Regional Cancer Centre, 800 Commissioners Road E., London, Ontario, N6A 4L6 Canada (Canada); Mymryk, Joe S., E-mail: jmymryk@uwo.ca [Department of Microbiology and Immunology, The University of Western Ontario, A4-833 London Regional Cancer Centre, 800 Commissioners Road E., London, Ontario, N6A 4L6 Canada (Canada); Department of Oncology, The University of Western Ontario, London Regional Cancer Centre, Ontario (Canada)

    2014-11-15

    The immortalizing function of the human adenovirus 5 E1A oncoprotein requires efficient localization to the nucleus. In 1987, a consensus monopartite nuclear localization sequence (NLS) was identified at the C-terminus of E1A. Since that time, various experiments have suggested that other regions of E1A influence nuclear import. In addition, a novel bipartite NLS was recently predicted at the C-terminal region of E1A in silico. In this study, we used immunofluorescence microscopy and co-immunoprecipitation analysis with importin-α to verify that full nuclear localization of E1A requires the well characterized NLS spanning residues 285–289, as well as a second basic patch situated between residues 258 and 263 ({sup 258}RVGGRRQAVECIEDLLNEPGQPLDLSCKRPRP{sup 289}). Thus, the originally described NLS located at the C-terminus of E1A is actually a bipartite signal, which had been misidentified in the existing literature as a monopartite signal, altering our understanding of one of the oldest documented NLSs. - Highlights: • Human adenovirus E1A is localized to the nucleus. • The C-terminus of E1A contains a bipartite nuclear localization signal (NLS). • This signal was previously misidentified to be a monopartite NLS. • Key basic amino acid residues within this sequence are highly conserved.

  10. Case study of simultaneous observations of sporadic sodium layer, E-region field-aligned irregularities and sporadic E layer at low latitude of China

    Science.gov (United States)

    Xie, H. Y.; Ning, B. Q.; Zhao, X. K.; Hu, L. H.

    2017-03-01

    Using the Na lidar at Haikou (20.0°N, 110.3°E), the VHF coherent radar and the digital ionosonde both at Sanya (18.4°N, 109.6°E), cases of simultaneous observations of sporadic sodium layer (SSL), E-region field-aligned irregularities (FAI) and sporadic E layer (Es) in the mesosphere and lower thermosphere (MLT) region at low latitude of China are studied. It is found that SSL occurs simultaneously or follows the enhancement of Es and FAI. The Es, FAI and SSL descend slowly with time which is mostly controlled by the diurnal tide (DT). Besides, the interaction of gravity wave (GW) with tides can cause oscillations in FAI and SSL. Our observations support the neutralization of ions for SSL formation: when the metallic ions layer descents to the altitudes where models predict, the sodium ions convert rapidly to atomic Na that may form an SSL event. Moreover, the SSL peak density will increase (decrease) in the convergence (divergence) vertical shear region of zonal wind.

  11. Angular analysis of the $B^0 \\rightarrow K^{*0} e^+ e^-$ decay in the low-$q^2$ region

    CERN Document Server

    Aaij, Roel; Adinolfi, Marco; Affolder, Anthony; Ajaltouni, Ziad; Akar, Simon; Albrecht, Johannes; Alessio, Federico; Alexander, Michael; Ali, Suvayu; Alkhazov, Georgy; Alvarez Cartelle, Paula; Alves Jr, Antonio Augusto; Amato, Sandra; Amerio, Silvia; Amhis, Yasmine; An, Liupan; Anderlini, Lucio; Anderson, Jonathan; Andreassen, Rolf; Andreotti, Mirco; Andrews, Jason; Appleby, Robert; Aquines Gutierrez, Osvaldo; Archilli, Flavio; Artamonov, Alexander; Artuso, Marina; Aslanides, Elie; Auriemma, Giulio; Baalouch, Marouen; Bachmann, Sebastian; Back, John; Badalov, Alexey; Baesso, Clarissa; Baldini, Wander; Barlow, Roger; Barschel, Colin; Barsuk, Sergey; Barter, William; Batozskaya, Varvara; Battista, Vincenzo; Bay, Aurelio; Beaucourt, Leo; Beddow, John; Bedeschi, Franco; Bediaga, Ignacio; Belogurov, Sergey; Belyaev, Ivan; Ben-Haim, Eli; Bencivenni, Giovanni; Benson, Sean; Benton, Jack; Berezhnoy, Alexander; Bernet, Roland; Bertolin, Alessandro; Bettler, Marc-Olivier; van Beuzekom, Martinus; Bien, Alexander; Bifani, Simone; Bird, Thomas; Bizzeti, Andrea; Blake, Thomas; Blanc, Frédéric; Blouw, Johan; Blusk, Steven; Bocci, Valerio; Bondar, Alexander; Bondar, Nikolay; Bonivento, Walter; Borghi, Silvia; Borgia, Alessandra; Borsato, Martino; Bowcock, Themistocles; Bowen, Espen Eie; Bozzi, Concezio; Brett, David; Britsch, Markward; Britton, Thomas; Brodzicka, Jolanta; Brook, Nicholas; Bursche, Albert; Buytaert, Jan; Cadeddu, Sandro; Calabrese, Roberto; Calvi, Marta; Calvo Gomez, Miriam; Campana, Pierluigi; Campora Perez, Daniel; Capriotti, Lorenzo; Carbone, Angelo; Carboni, Giovanni; Cardinale, Roberta; Cardini, Alessandro; Carson, Laurence; Carvalho Akiba, Kazuyoshi; Casanova Mohr, Raimon; Casse, Gianluigi; Cassina, Lorenzo; Castillo Garcia, Lucia; Cattaneo, Marco; Cauet, Christophe; Cenci, Riccardo; Charles, Matthew; Charpentier, Philippe; Chefdeville, Maximilien; Chen, Shanzhen; Cheung, Shu-Faye; Chiapolini, Nicola; Chrzaszcz, Marcin; Cid Vidal, Xabier; Ciezarek, Gregory; Clarke, Peter; Clemencic, Marco; Cliff, Harry; Closier, Joel; Coco, Victor; Cogan, Julien; Cogneras, Eric; Cogoni, Violetta; Cojocariu, Lucian; Collazuol, Gianmaria; Collins, Paula; Comerma-Montells, Albert; Contu, Andrea; Cook, Andrew; Coombes, Matthew; Coquereau, Samuel; Corti, Gloria; Corvo, Marco; Counts, Ian; Couturier, Benjamin; Cowan, Greig; Craik, Daniel Charles; Crocombe, Andrew Christopher; Cruz Torres, Melissa Maria; Cunliffe, Samuel; Currie, Robert; D'Ambrosio, Carmelo; Dalseno, Jeremy; David, Pascal; David, Pieter; Davis, Adam; De Bruyn, Kristof; De Capua, Stefano; De Cian, Michel; De Miranda, Jussara; De Paula, Leandro; De Silva, Weeraddana; De Simone, Patrizia; Dean, Cameron Thomas; Decamp, Daniel; Deckenhoff, Mirko; Del Buono, Luigi; Déléage, Nicolas; Derkach, Denis; Deschamps, Olivier; Dettori, Francesco; Dey, Biplab; Di Canto, Angelo; Di Domenico, Antonio; Di Ruscio, Francesco; Dijkstra, Hans; Donleavy, Stephanie; Dordei, Francesca; Dorigo, Mirco; Dosil Suárez, Alvaro; Dossett, David; Dovbnya, Anatoliy; Dreimanis, Karlis; Dujany, Giulio; Dupertuis, Frederic; Durante, Paolo; Dzhelyadin, Rustem; Dziurda, Agnieszka; Dzyuba, Alexey; Easo, Sajan; Egede, Ulrik; Egorychev, Victor; Eidelman, Semen; Eisenhardt, Stephan; Eitschberger, Ulrich; Ekelhof, Robert; Eklund, Lars; El Rifai, Ibrahim; Elsasser, Christian; Ely, Scott; Esen, Sevda; Evans, Hannah Mary; Evans, Timothy; Falabella, Antonio; Färber, Christian; Farinelli, Chiara; Farley, Nathanael; Farry, Stephen; Fay, Robert; Ferguson, Dianne; Fernandez Albor, Victor; Ferreira Rodrigues, Fernando; Ferro-Luzzi, Massimiliano; Filippov, Sergey; Fiore, Marco; Fiorini, Massimiliano; Firlej, Miroslaw; Fitzpatrick, Conor; Fiutowski, Tomasz; Fol, Philip; Fontana, Marianna; Fontanelli, Flavio; Forty, Roger; Francisco, Oscar; Frank, Markus; Frei, Christoph; Frosini, Maddalena; Fu, Jinlin; Furfaro, Emiliano; Gallas Torreira, Abraham; Galli, Domenico; Gallorini, Stefano; Gambetta, Silvia; Gandelman, Miriam; Gandini, Paolo; Gao, Yuanning; García Pardiñas, Julián; Garofoli, Justin; Garra Tico, Jordi; Garrido, Lluis; Gascon, David; Gaspar, Clara; Gastaldi, Ugo; Gauld, Rhorry; Gavardi, Laura; Gazzoni, Giulio; Geraci, Angelo; Gersabeck, Evelina; Gersabeck, Marco; Gershon, Timothy; Ghez, Philippe; Gianelle, Alessio; Gianì, Sebastiana; Gibson, Valerie; Giubega, Lavinia-Helena; Gligorov, V.V.; Göbel, Carla; Golubkov, Dmitry; Golutvin, Andrey; Gomes, Alvaro; Gotti, Claudio; Grabalosa Gándara, Marc; Graciani Diaz, Ricardo; Granado Cardoso, Luis Alberto; Graugés, Eugeni; Graverini, Elena; Graziani, Giacomo; Grecu, Alexandru; Greening, Edward; Gregson, Sam; Griffith, Peter; Grillo, Lucia; Grünberg, Oliver; Gui, Bin; Gushchin, Evgeny; Guz, Yury; Gys, Thierry; Hadjivasiliou, Christos; Haefeli, Guido; Haen, Christophe; Haines, Susan; Hall, Samuel; Hamilton, Brian; Hampson, Thomas; Han, Xiaoxue; Hansmann-Menzemer, Stephanie; Harnew, Neville; Harnew, Samuel; Harrison, Jonathan; He, Jibo; Head, Timothy; Heijne, Veerle; Hennessy, Karol; Henrard, Pierre; Henry, Louis; Hernando Morata, Jose Angel; van Herwijnen, Eric; Heß, Miriam; Hicheur, Adlène; Hill, Donal; Hoballah, Mostafa; Hombach, Christoph; Hulsbergen, Wouter; Hussain, Nazim; Hutchcroft, David; Hynds, Daniel; Idzik, Marek; Ilten, Philip; Jacobsson, Richard; Jaeger, Andreas; Jalocha, Pawel; Jans, Eddy; Jawahery, Abolhassan; Jing, Fanfan; John, Malcolm; Johnson, Daniel; Jones, Christopher; Joram, Christian; Jost, Beat; Jurik, Nathan; Kandybei, Sergii; Kanso, Walaa; Karacson, Matthias; Karbach, Moritz; Karodia, Sarah; Kelsey, Matthew; Kenyon, Ian; Kenzie, Matthew; Ketel, Tjeerd; Khanji, Basem; Khurewathanakul, Chitsanu; Klaver, Suzanne; Klimaszewski, Konrad; Kochebina, Olga; Kolpin, Michael; Komarov, Ilya; Koopman, Rose; Koppenburg, Patrick; Korolev, Mikhail; Kravchuk, Leonid; Kreplin, Katharina; Kreps, Michal; Krocker, Georg; Krokovny, Pavel; Kruse, Florian; Kucewicz, Wojciech; Kucharczyk, Marcin; Kudryavtsev, Vasily; Kurek, Krzysztof; Kvaratskheliya, Tengiz; La Thi, Viet Nga; Lacarrere, Daniel; Lafferty, George; Lai, Adriano; Lambert, Dean; Lambert, Robert W; Lanfranchi, Gaia; Langenbruch, Christoph; Langhans, Benedikt; Latham, Thomas; Lazzeroni, Cristina; Le Gac, Renaud; van Leerdam, Jeroen; Lees, Jean-Pierre; Lefèvre, Regis; Leflat, Alexander; Lefrançois, Jacques; Leroy, Olivier; Lesiak, Tadeusz; Leverington, Blake; Li, Yiming; Likhomanenko, Tatiana; Liles, Myfanwy; Lindner, Rolf; Linn, Christian; Lionetto, Federica; Liu, Bo; Lohn, Stefan; Longstaff, Iain; Lopes, Jose; Lowdon, Peter; Lucchesi, Donatella; Luo, Haofei; Lupato, Anna; Luppi, Eleonora; Lupton, Oliver; Machefert, Frederic; Machikhiliyan, Irina V; Maciuc, Florin; Maev, Oleg; Malde, Sneha; Malinin, Alexander; Manca, Giulia; Mancinelli, Giampiero; Manning, Peter Michael; Mapelli, Alessandro; Maratas, Jan; Marchand, Jean François; Marconi, Umberto; Marin Benito, Carla; Marino, Pietro; Märki, Raphael; Marks, Jörg; Martellotti, Giuseppe; Martinelli, Maurizio; Martinez Santos, Diego; Martinez Vidal, Fernando; Martins Tostes, Danielle; Massafferri, André; Matev, Rosen; Mathe, Zoltan; Matteuzzi, Clara; Maurin, Brice; Mazurov, Alexander; McCann, Michael; McCarthy, James; McNab, Andrew; McNulty, Ronan; McSkelly, Ben; Meadows, Brian; Meier, Frank; Meissner, Marco; Merk, Marcel; Milanes, Diego Alejandro; Minard, Marie-Noelle; Moggi, Niccolò; Molina Rodriguez, Josue; Monteil, Stephane; Morandin, Mauro; Morawski, Piotr; Mordà, Alessandro; Morello, Michael Joseph; Moron, Jakub; Morris, Adam Benjamin; Mountain, Raymond; Muheim, Franz; Müller, Katharina; Mussini, Manuel; Muster, Bastien; Naik, Paras; Nakada, Tatsuya; Nandakumar, Raja; Nasteva, Irina; Needham, Matthew; Neri, Nicola; Neubert, Sebastian; Neufeld, Niko; Neuner, Max; Nguyen, Anh Duc; Nguyen, Thi-Dung; Nguyen-Mau, Chung; Nicol, Michelle; Niess, Valentin; Niet, Ramon; Nikitin, Nikolay; Nikodem, Thomas; Novoselov, Alexey; O'Hanlon, Daniel Patrick; Oblakowska-Mucha, Agnieszka; Obraztsov, Vladimir; Ogilvy, Stephen; Okhrimenko, Oleksandr; Oldeman, Rudolf; Onderwater, Gerco; Orlandea, Marius; Osorio Rodrigues, Bruno; Otalora Goicochea, Juan Martin; Otto, Adam; Owen, Patrick; Oyanguren, Maria Arantza; Pal, Bilas Kanti; Palano, Antimo; Palombo, Fernando; Palutan, Matteo; Panman, Jacob; Papanestis, Antonios; Pappagallo, Marco; Pappalardo, Luciano; Parkes, Christopher; Parkinson, Christopher John; Passaleva, Giovanni; Patel, Girish; Patel, Mitesh; Patrignani, Claudia; Pearce, Alex; Pellegrino, Antonio; Penso, Gianni; Pepe Altarelli, Monica; Perazzini, Stefano; Perret, Pascal; Pescatore, Luca; Pesen, Erhan; Petridis, Konstantin; Petrolini, Alessandro; Picatoste Olloqui, Eduardo; Pietrzyk, Boleslaw; Pilař, Tomas; Pinci, Davide; Pistone, Alessandro; Playfer, Stephen; Plo Casasus, Maximo; Polci, Francesco; Poluektov, Anton; Polyakov, Ivan; Polycarpo, Erica; Popov, Alexander; Popov, Dmitry; Popovici, Bogdan; Potterat, Cédric; Price, Eugenia; Price, Joseph David; Prisciandaro, Jessica; Pritchard, Adrian; Prouve, Claire; Pugatch, Valery; Puig Navarro, Albert; Punzi, Giovanni; Qian, Wenbin; Quagliani, Renato; Rachwal, Bartolomiej; Rademacker, Jonas; Rakotomiaramanana, Barinjaka; Rama, Matteo; Rangel, Murilo; Raniuk, Iurii; Rauschmayr, Nathalie; Raven, Gerhard; Redi, Federico; Reichert, Stefanie; Reid, Matthew; dos Reis, Alberto; Ricciardi, Stefania; Richards, Sophie; Rihl, Mariana; Rinnert, Kurt; Rives Molina, Vincente; Robbe, Patrick; Rodrigues, Ana Barbara; Rodrigues, Eduardo; Rodriguez Perez, Pablo; Roiser, Stefan; Romanovsky, Vladimir; Romero Vidal, Antonio; Rotondo, Marcello; Rouvinet, Julien; Ruf, Thomas; Ruiz, Hugo; Ruiz Valls, Pablo; Saborido Silva, Juan Jose; Sagidova, Naylya; Sail, Paul; Saitta, Biagio; Salustino Guimaraes, Valdir; Sanchez Mayordomo, Carlos; Sanmartin Sedes, Brais; Santacesaria, Roberta; Santamarina Rios, Cibran; Santovetti, Emanuele; Sarti, Alessio; Satriano, Celestina; Satta, Alessia; Saunders, Daniel Martin; Savrina, Darya; Schiller, Manuel; Schindler, Heinrich; Schlupp, Maximilian; Schmelling, Michael; Schmidt, Burkhard; Schneider, Olivier; Schopper, Andreas; Schune, Marie Helene; Schwemmer, Rainer; Sciascia, Barbara; Sciubba, Adalberto; Semennikov, Alexander; Sepp, Indrek; Serra, Nicola; Serrano, Justine; Sestini, Lorenzo; Seyfert, Paul; Shapkin, Mikhail; Shapoval, Illya; Shcheglov, Yury; Shears, Tara; Shekhtman, Lev; Shevchenko, Vladimir; Shires, Alexander; Silva Coutinho, Rafael; Simi, Gabriele; Sirendi, Marek; Skidmore, Nicola; Skillicorn, Ian; Skwarnicki, Tomasz; Smith, Anthony; Smith, Edmund; Smith, Eluned; Smith, Jackson; Smith, Mark; Snoek, Hella; Sokoloff, Michael; Soler, Paul; Soomro, Fatima; Souza, Daniel; Souza De Paula, Bruno; Spaan, Bernhard; Spradlin, Patrick; Sridharan, Srikanth; Stagni, Federico; Stahl, Marian; Stahl, Sascha; Steinkamp, Olaf; Stenyakin, Oleg; Sterpka, Christopher Francis; Stevenson, Scott; Stoica, Sabin; Stone, Sheldon; Storaci, Barbara; Stracka, Simone; Straticiuc, Mihai; Straumann, Ulrich; Stroili, Roberto; Sun, Liang; Sutcliffe, William; Swientek, Krzysztof; Swientek, Stefan; Syropoulos, Vasileios; Szczekowski, Marek; Szczypka, Paul; Szumlak, Tomasz; T'Jampens, Stephane; Teklishyn, Maksym; Tellarini, Giulia; Teubert, Frederic; Thomas, Christopher; Thomas, Eric; van Tilburg, Jeroen; Tisserand, Vincent; Tobin, Mark; Todd, Jacob; Tolk, Siim; Tomassetti, Luca; Tonelli, Diego; Topp-Joergensen, Stig; Torr, Nicholas; Tournefier, Edwige; Tourneur, Stephane; Trabelsi, Karim; Tran, Minh Tâm; Tresch, Marco; Trisovic, Ana; Tsaregorodtsev, Andrei; Tsopelas, Panagiotis; Tuning, Niels; Ubeda Garcia, Mario; Ukleja, Artur; Ustyuzhanin, Andrey; Uwer, Ulrich; Vacca, Claudia; Vagnoni, Vincenzo; Valenti, Giovanni; Vallier, Alexis; Vazquez Gomez, Ricardo; Vazquez Regueiro, Pablo; Vázquez Sierra, Carlos; Vecchi, Stefania; Velthuis, Jaap; Veltri, Michele; Veneziano, Giovanni; Vesterinen, Mika; Viana Barbosa, Joao Vitor; Viaud, Benoit; Vieira, Daniel; Vieites Diaz, Maria; Vilasis-Cardona, Xavier; Vollhardt, Achim; Volyanskyy, Dmytro; Voong, David; Vorobyev, Alexey; Vorobyev, Vitaly; Voß, Christian; de Vries, Jacco; Waldi, Roland; Wallace, Charlotte; Wallace, Ronan; Walsh, John; Wandernoth, Sebastian; Wang, Jianchun; Ward, David; Watson, Nigel; Websdale, David; Whitehead, Mark; Wiedner, Dirk; Wilkinson, Guy; Wilkinson, Michael; Williams, Matthew; Williams, Mike; Wilschut, Hans; Wilson, Fergus; Wimberley, Jack; Wishahi, Julian; Wislicki, Wojciech; Witek, Mariusz; Wormser, Guy; Wotton, Stephen; Wright, Simon; Wyllie, Kenneth; Xie, Yuehong; Xing, Zhou; Xu, Zhirui; Yang, Zhenwei; Yuan, Xuhao; Yushchenko, Oleg; Zangoli, Maria; Zavertyaev, Mikhail; Zhang, Liming; Zhang, Wen Chao; Zhang, Yanxi; Zhelezov, Alexey; Zhokhov, Anatoly; Zhong, Liang

    2015-01-01

    An angular analysis of the $B^0 \\rightarrow K^{*0} e^+ e^-$ decay is performed using a data sample, corresponding to an integrated luminosity of 3.0 ${\\mbox{fb}^{-1}}$, collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of 7 and 8 TeV during 2011 and 2012. For the first time several observables are measured in the dielectron mass squared ($q^2$) interval between 0.002 and 1.120${\\mathrm{\\,Ge\\kern -0.1em V^2\\!/}c^4}$. The angular observables $F_{\\mathrm{L}}$ and $A_{\\mathrm{T}}^{\\mathrm{Re}}$ which are related to the $K^{*0}$ polarisation and to the lepton forward-backward asymmetry, are measured to be $F_{\\mathrm{L}}= 0.16 \\pm 0.06 \\pm0.03$ and $A_{\\mathrm{T}}^{\\mathrm{Re}} = 0.10 \\pm 0.18 \\pm 0.05$, where the first uncertainty is statistical and the second systematic. The angular observables $A_{\\mathrm{T}}^{(2)}$ and $A_{\\mathrm{T}}^{\\mathrm{Im}}$ which are sensitive to the photon polarisation in this $q^2$ range, are found to be $A_{\\mathrm{T}}^{(2)} = -0.23 \\pm 0.23 \\pm 0.05$ a...

  12. A relação inseparável entre o Regional e o Nacional: Monteiro Lobato e a Paulistanidade

    Directory of Open Access Journals (Sweden)

    Danyllo Di Giorgio Martins da Mota

    2012-12-01

    Full Text Available Esse artigo tem como objetivo discutir a definição conceitual da idéia de Paulistanidade e sua presença na obra de Monteiro Lobato durante a década de 1920, sobretudo no livro Mr. Slang e o Brasil de 1927. A valorização do estado de São Paulo como lugar de modernidade e modernização se relacionou, a partir do final do século XIX, com a construção de imagens do estado paulista como símbolo a ser seguido pelo Brasil. Nesses debates, o trabalho de Monteiro Lobato acaba por expor a relação indissociável entre as esferas regional e nacional.

  13. Globalização e desenvolvimento regional na Tríplice Fronteira

    Directory of Open Access Journals (Sweden)

    Eric Gustavo Cardin

    2009-01-01

    Full Text Available This paper discusses the relationship between the process of globalization and the opportunities for regional development. In order to do that, it theoretically discusses the concepts of globalization, governance and paradiplomacia, noting some of the conflicts and contradictions existing in some of the discussions between skeptical and globalistas. The article also presents empirical considerations by observing the socioeconomic development of the region known as the Triple Frontier (Brazil, Paraguay and Argentina, exploring the interdependence relationship and questioning the contributions that the conceptual discussions bring for the strengthening of reflections referring to local and regional growth.

  14. The variations of ionosphere critical frequency of E layer over the equatorial geomagnetic region in Southeast Asia

    Science.gov (United States)

    Kenpankho, Prasert; Ishii, Mamoru; Supnithi, Pornchai

    2016-07-01

    We investigate the values of the critical frequency of the ionospheric E layer, foE, obtained at Chumphon ionospheric observatory station, Thailand. For a declining phase of the solar cycle 23 during the year 2005-2008 and an inclining phase of the solar cycle 24 during the year 2009-2013, the foE data have been used to investigate the foE variations over the equatorial geomagnetic region in Southeast Asia. A comparison between the observation data and International Reference Ionosphere (IRI) 2012 model has also been investigated and studied. The results show that the foE obtained from IRI 2012 model underestimates foE from Chumphon station especially during the period of 7-11 am and after 6 pm for each day and all seasons. As the results combining with the previous investigations, we suggest that the underestimation of ionospheric foE by IRI 2012 model is helpful for the correction and improvement of IRI model in an equatorial Asia region.

  15. First Measurement of the Double Spin Asymmetry in $\\vec{e}\\vec{p}\\to e' \\pi^+ n$ in the Resonance Region

    CERN Document Server

    De Vita, R

    2002-01-01

    The double spin asymmetry in the $\\vec{e}\\vec{p}\\to e' \\pi^+ n$ reaction has been measured for the first time in the resonance region for four-momentum transfer $Q^2=0.35-1.5$ GeV$^2$. Data were taken at Jefferson Lab with the CEBAF Large Acceptance Spectrometer (CLAS) using a 2.6 GeV polarized electron beam incident on a polarized solid NH$_3$ target. Comparison with predictions of phenomenological models shows strong sensitivity to resonance contributions. Helicity-1/2 transitions are found to be dominant in the second and third resonance regions. The measured asymmetry is consistent with a faster rise with $Q^2$ of the helicity asymmetry $A_1$ for the $F_{15}(1680)$ resonance than expected from the analysis of the unpolarized data.

  16. Transcriptional analyses of the region of the equine herpesvirus type 4 genome encoding glycoproteins I and E.

    Science.gov (United States)

    Damiani, A M; Jang, H K; Matsumura, T; Yokoyama, N; Miyazawa, T; Mikami, T

    1999-01-01

    To map the transcripts encoding the equine herpesvirus type 4 (EHV-4) glycoproteins I (gI) and E (gE), transcriptional analyses were performed at the right part of the unique short segment of EHV-4 genome. The results revealed that the gI gene is encoded by a 1.6-kb transcript which is 3' coterminal with a 3.0-kb gD mRNA while the gE gene is encoded by two transcripts of 3.5- and 2.4-kb in size. The transcriptional patterns described in this study for the EHV-4 gI and gE are similar to those found in the equivalent region of herpes simplex virus type 1 and feline herpesvirus type 1. Characterization of EHV-4 gI and gE glycoprotein genes may facilitate future studies to define their roles in the EHV-4 infection.

  17. Comparação de lornoxicam e fentanil adicionados à lidocaína em anestesia regional intravenosa

    OpenAIRE

    Nezih Sertoz; Nazan Kocaoglu; Hilmi Ö. Ayanoğlu

    2013-01-01

    JUSTIFICATIVA E OBJETIVO: Comparar os efeitos analgésicos nos períodos intra e pós-operatório de lornoxicam e fentanil adicionados à lidocaína para anestesia regional intravenosa (ARIV) em um grupo de pacientes submetidos à cirurgia de mão. MÉTODOS: Estudo randômico, duplo-cego e controlado. Foram incluídos e randomizados 45 pacientes em três grupos: o Grupo I recebeu 3 mg.kg-1 de lidocaína a 2% (40 mL); o Grupo II recebeu 3 mg.kg-1 de lidocaína (38 mL) + 2 mL de lornoxicam; o Grupo III receb...

  18. High-latitude E and F region coupling signature: A case study results from rapid-run ionosonde

    Science.gov (United States)

    Shalimov, S.; Kozlovsky, A.

    2015-04-01

    Rapid-run ionosonde installed in the high-latitude Sodankylä Geophysical Observatory enables us to observe for the first time extraordinary details of E-F region coupling process in high-latitude ionosphere during geomagnetically quiet period. We present an example on 15 August 2009 when a dense, patchy sporadic E layer was detected. Associated with this unstable sporadic E layer, exhibiting in addition an unusual enhancement with a vertical extent of about 10 km, the highly structured F layer plasma was observed with apparent plasma depletions. We examine this event taking into account the presence of mesoscale traveling ionospheric disturbances which can initiate coupling between these two regions and compare the data with current theories.

  19. VHF radar observations of the dip equatorial E-region during sunset in the Brazilian sector

    Directory of Open Access Journals (Sweden)

    C. M. Denardini

    2006-07-01

    Full Text Available Using the RESCO 50 MHz backscatter radar (2.33° S, 44.2° W, DIP: –0.5, at São Luís, Brazil, we obtained Range Time Intensity (RTI maps covering the equatorial electrojet heights during daytime and evening. These maps revealed a scattering region at an altitude of about 108 km during the sunset period. The type of 3-m irregularity region we present here has not been reported before in the literature, to our knowledge. It was mainly observed around the Southern Hemisphere summer-solstice period, under quiet magnetic activity condition. The occurrence of this echo region coincides in local time with the maximum intensity of an evening pre-reversal eastward electric field of the ionospheric F-region. A tentative explanation is proposed here in terms of the theory of the divergence of the equatorial electrojet (EEJ current in the evening ionosphere presented by Haerendel and Eccles (1992, to explain the partial contribution of the divergence to the development of the pre-reversal electric field. The theory predicts an enhanced zonal electric field and hence a vertical electric field below 300 km as a consequence of the EEJ divergence in the evening. The experimental results of the enhanced echoes from the higher heights of the EEJ region seem to provide evidence that the divergence of the EEJ current can indeed be the driver of the observed scattering region.

  20. Standardizzazione e validazione dei dati della pianificazione urbanistica locale nella regione del Veneto

    Directory of Open Access Journals (Sweden)

    Francesco Tomaello

    2013-06-01

    Full Text Available La Legge Regionale del Veneto n. 11 del 23 aprile 2004 ha introdotto varie innovazioni, tra cui l’obbligo per i Comuni di compilare in formato digitale i propri strumenti urbanistici, ed in particolare i Piani Regolatori Comunali, secondo una specifica di compilazione predisposta dalla stessa Regione, che prevede inparticolare anche l’obbligo di usare un formato GIS standardizzato.According to the Land Planning Act of Region Veneto (Italy,Municipalities have to compile their Local Land Plans (PRC –Piani Regolatori Comunali using a standardized GIS datamodel.The Region Veneto has issued such specifications about theGIS data model immediately after the entry into force of Lawn. 11 (2004.The Veneto Region has immediately activated a system for thevalidation of the GIS data of Plans coming from Municipalities.The system computes two indices to measure the compliancyof the incoming data with the data model according to art. 11of Law n. 11 (2004.For sure the operative model issued by the Law n. 11 (2004requires skilled technicians both from the side of the Municipalitiesfor the population of the geodatabase of the local landplan and from the side of the Veneto Region for the validation.The Veneto Region has set up a specific office staffed with GIS skilled personnel using a state-of-the-art software procedure for data validation. The workflow of data validation has been published by the Region in January 2007. The latest and improved release of GIS data model was issued in January 2010.The software procedure has been built on top of Intergraph’sGeoMedia GIS software.Currently the whole procedure for Local Land Planning is coherent with the SDI of Region Veneto - operative since 2011.According to INSPIRE Directive and some italian laws, RegionVeneto has started the design of the new workflow for the GIScomponent of local land planning. The leading concepts isthe Municipalities will be capable of validating autonomouslytheir GIS datasets

  1. A defined terminal region of the E. coli chromosome shows late segregation and high FtsK activity.

    Directory of Open Access Journals (Sweden)

    Marie Deghorain

    Full Text Available BACKGROUND: The FtsK DNA-translocase controls the last steps of chromosome segregation in E. coli. It translocates sister chromosomes using the KOPS DNA motifs to orient its activity, and controls the resolution of dimeric forms of sister chromosomes by XerCD-mediated recombination at the dif site and their decatenation by TopoIV. METHODOLOGY: We have used XerCD/dif recombination as a genetic trap to probe the interaction of FtsK with loci located in different regions of the chromosome. This assay revealed that the activity of FtsK is restricted to a ∼400 kb terminal region of the chromosome around the natural position of the dif site. Preferential interaction with this region required the tethering of FtsK to the division septum via its N-terminal domain as well as its translocation activity. However, the KOPS-recognition activity of FtsK was not required. Displacement of replication termination outside the FtsK high activity region had no effect on FtsK activity and deletion of a part of this region was not compensated by its extension to neighbouring regions. By observing the fate of fluorescent-tagged loci of the ter region, we found that segregation of the FtsK high activity region is delayed compared to that of its adjacent regions. SIGNIFICANCE: Our results show that a restricted terminal region of the chromosome is specifically dedicated to the last steps of chromosome segregation and to their coupling with cell division by FtsK.

  2. Prevalência de sobrepeso e obesidade nas regiões Nordeste e Sudeste do Brasil Overweight and obesity prevalence in Northeast and Southeast Regions of Brazil

    Directory of Open Access Journals (Sweden)

    Marcelo Militão Abrantes

    2003-06-01

    Full Text Available OBJETIVO: Avaliar a prevalência de sobrepeso e obesidade em crianças, adolescentes, adultos e idosos brasileiros das regiões Nordeste e Sudeste; MÉTODOS: Avaliação antropométrica de 17.184 pessoas, estudadas na Pesquisa sobre Padrões de Vida (PPV realizada pelo IBGE em 1996/97, através do índice de massa corporal sendo usados como limite para sobrepeso e obesidade os valores propostos por Cole et al. por permitirem uma continuidade de critério de sobrepeso e obesidade na infância, adolescência e idade adulta. RESULTADOS: Predomínio do sexo feminino, 53,1%, na população estudada. A média de idade foi de 29 anos e 5 meses (desvio padrão de ± 20 anos, a mediana foi de 25 anos e 6 meses. A prevalência de sobrepeso foi de 10,8% entre crianças, 9,9% nos adolescentes e 28,3% entre adultos e a de obesidade foi 7,3%, 1,8% e 9,7%, respectivamente. Observado um aumento gradativo da prevalência de sobrepeso e obesidade desde a infância até a idade adulta, com declínio entre os idosos. CONCLUSÕES: Prevalência conjunta de sobrepeso e obesidade na população brasileira é maior no sexo feminino sendo que mais da metade das mulheres das regiões Nordeste e Sudeste do Brasil, com idade entre 50 e 69 anos, têm sobrepeso e/ou obesidade. A comparação de estudos de prevalência de sobrepeso e obesidade na infância e adolescência é dificultada pela escassez de estudos populacionais nacionais e diversidade de critérios utilizados na avaliação nutricional.OBJECTIVE: to evaluate the prevalence of overweight and obesity in children, adolescents, adults and elderlies from Northeast and Southeast regions of Brazil. METHODS: anthropometric evaluation of 17.184 people, studied in Life Pattern Research conducted by Brazilian Institute of Geographic and Statistics in 1996/97, by body mass index. Overweight and obesity definitions according to body mass index values proposed by Cole et al. which are related to adult definition. RESULTS: It

  3. The participatory democracy and the regional legislation. Laws numbers 69/2007 of Tuscany and number 3/2010 of region of Emilia Romagna Democrazia di prossimità e legislazione regionale. Le leggi n. 69 del 2007 della regione toscana e n. 3 del 2010 della regione emilia romagna

    Directory of Open Access Journals (Sweden)

    Gianluca Sgueo

    2010-11-01

    Full Text Available The laws n. 69/2007 and n. 3/2010 of, respectively, the regional administrations of Tuscany and Emilia Romagna, introduce new rules for participation of stakeholders within the regional administrative decision-making processes. Both the laws aim at improving the regional participatory democracy through the integration – and occasionally through the substitution – of the Italian legislation. This article explores and discusses the participatory procedures of the laws n. 69/2007 and n. 3/3010. The article also describes the administrative structures created by each of the two laws and its functions. With regard to the case of Tuscany specific attention is given to the relationship between the political and the administrative spheres of competence. The article particularly focuses on the activities expounded by the independent administrative authority created by the law n. 69/2007, which draws from the French experience of the débat publique and aims at supervising and controlling the participatory guarantees at the regional level. With regard to the case of Emilia Romagna, specific focus is put on the activity of the Technical Unit for Participatory Rights and the controlling Committee. Both are administrative organs operating within the framework of the law in order to guarantee the participatory rights of the interested parties. The article concludes by comparing the pluses and the minuses of both the laws and by introducing a broader reflection on the evolution of participatory rights at the regional level, and their likeness to become substitute of the national model of participation.Le leggi regionali n. 69 del 2007 della Toscana, contenente “Norme sulla promozione della partecipazione alla elaborazione delle politiche regionali e locali”, e n. 3 del 9 febbraio 2010 dell’Emilia Romagna, contenente “Norme per la definizione, riordino e promozione delle procedure di consultazione e partecipazione alla elaborazione delle politiche

  4. 4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms.

    Directory of Open Access Journals (Sweden)

    Kyle J Nakamura

    Full Text Available Human antibody 4E10 targets the highly conserved membrane-proximal external region (MPER of the HIV-1 transmembrane glycoprotein, gp41, and has extraordinarily broad neutralizing activity. It is considered by many to be a prototype for vaccine development. In this study, we describe four subjects infected with viruses carrying rare MPER polymorphisms associated with resistance to 4E10 neutralization. In one case resistant virus carrying a W680G substitution was transmitted from mother to infant. We used site-directed mutagenesis to demonstrate that the W680G substitution is necessary for conferring the 4E10-resistant phenotype, but that it is not sufficient to transfer the phenotype to a 4E10-sensitive Env. Our third subject carried Envs with a W680R substitution causing variable resistance to 4E10, indicating that residues outside the MPER are required to confer the phenotype. A fourth subject possessed a F673L substitution previously associated with 4E10 resistance. For all three subjects with W680 polymorphisms, we observed additional residues in the MPER that co-varied with position 680 and preserved charged distributions across this region. Our data provide important caveats for vaccine development targeting the MPER. Naturally occurring Env variants described in our study also represent unique tools for probing the structure-function of HIV-1 envelope.

  5. Star formation in bright-rimmed clouds and cluster associated with W5 E H{\\sc ii} region

    CERN Document Server

    Chauhan, Neelam; Ogura, K; Jose, J; Ojha, D K; Samal, M R; Mito, H

    2011-01-01

    The aim of this paper is to present the results of photometric investigations of the central cluster of the W5 E region as well as a follow-up study of the triggered star formation in and around bright-rimmed clouds (BRCs). We have carried out wide field $UBVI_c$ and deep $VI_c$ photometry of the W5 E H{\\sc ii} region. A distance of $\\sim$2.1 kpc and a mean age of $\\sim$1.3 Myr have been obtained for the central cluster. The young stellar objects (YSOs) associated with the region are identified on the basis of near-infrared and mid-infrared observations. We confirmed our earlier results that the average age of the YSOs lying on/inside the rim are younger than those lying outside the rim. The global distribution of the YSOs shows an aligned distribution from the ionising source to the BRCs. These facts indicate that a series of radiation driven implosion processes proceeded from near the central ionising source towards the periphery of the W5 E H{\\sc ii} region. We found that, in general, the age distributions...

  6. Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region

    Directory of Open Access Journals (Sweden)

    Enrico Lavezzo

    2016-03-01

    Full Text Available Different human papillomavirus (HPV types are characterized by differences in tissue tropism and ability to promote cell proliferation and transformation. In addition, clinical and experimental studies have shown that some genetic variants/lineages of high-risk HPV (HR-HPV types are characterized by increased oncogenic activity and probability to induce cancer. In this study, we designed and validated a new method based on multiplex PCR-deep sequencing of the E6/E7 region of HR-HPV types to characterize HPV intra-type variants in clinical specimens. Validation experiments demonstrated that this method allowed reliable identification of the different lineages of oncogenic HPV types. Advantages of this method over other published methods were represented by its ability to detect variants of all HR-HPV types in a single reaction, to detect variants of HR-HPV types in clinical specimens with multiple infections, and, being based on sequencing of the full E6/E7 region, to detect amino acid changes in these oncogenes potentially associated with increased transforming activity.

  7. Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region.

    Science.gov (United States)

    Lavezzo, Enrico; Masi, Giulia; Toppo, Stefano; Franchin, Elisa; Gazzola, Valentina; Sinigaglia, Alessandro; Masiero, Serena; Trevisan, Marta; Pagni, Silvana; Palù, Giorgio; Barzon, Luisa

    2016-03-14

    Different human papillomavirus (HPV) types are characterized by differences in tissue tropism and ability to promote cell proliferation and transformation. In addition, clinical and experimental studies have shown that some genetic variants/lineages of high-risk HPV (HR-HPV) types are characterized by increased oncogenic activity and probability to induce cancer. In this study, we designed and validated a new method based on multiplex PCR-deep sequencing of the E6/E7 region of HR-HPV types to characterize HPV intra-type variants in clinical specimens. Validation experiments demonstrated that this method allowed reliable identification of the different lineages of oncogenic HPV types. Advantages of this method over other published methods were represented by its ability to detect variants of all HR-HPV types in a single reaction, to detect variants of HR-HPV types in clinical specimens with multiple infections, and, being based on sequencing of the full E6/E7 region, to detect amino acid changes in these oncogenes potentially associated with increased transforming activity.

  8. PENSAR O TERRITÓRIO E A REGIÃO: por uma agenda de desenvolvimento regional

    Directory of Open Access Journals (Sweden)

    Claudio Antonio Gonçalves Egler

    2013-01-01

    Full Text Available In the contemporary scenario, where there are strong evidences that the global economy is gradually moving to the enhancement of knowledge and specialized services as a source of income and employment, we delineate a new spatial geometry between cities on global scale, as well as among several centers nationwide and regionally. Capital and information flows in accelerated speed between firms situated in different locations at the same time as the relative distances within the large cities are becoming larger due to congestion and increasing socio-spatial segregation among its urban sub centers. In this context, it is argued that the importance of a regional development agenda is in ability to incorporate prospective territorial planning as a tool to build through boosting potential of the regions that value their endogenous components in order to facilitate a negotiated agreement among the public and private actors to promote three basic principles: territorial cohesion, the polycentricity and the sustainability.

  9. New probe of M1 and E1 strengths in GDR regions

    Energy Technology Data Exchange (ETDEWEB)

    Hayakawa, T. [Japan Atomic Energy Agency and National Astronomical Observatory in Japan (Japan); Ogata, K. [RCNP, Osaka University (Japan); Miyamoto, S.; Mochizuki, T.; Horikawa, K.; Amano, S. [University of Hyogo (Japan); Imazaki, K.; Li, D.; Izawa, Y. [Institute for Laser Technology (Japan); Chiba, S. [Tokyo Institute of Technology (Japan)

    2014-05-02

    The M1 strengths (or level density of 1{sup +} states) are of importance for estimation of interaction strengths between neutrinos and nuclei for the study of the supernova neutrino-process. In 1957, Agodi predicted theoretically angular distribution of neutrons emitted from states excited via dipole transitions with linearly polarized gamma-ray beam at the polar angle of θ=90° should be followed by a simple function, a + b cos(2φ), where φ, is azimuthal angel. However, this theoretical prediction has not been verified over the wide mass region except for light nuclei as deuteron. We have measured neutron angular distributions with (polarized gamma, n) reactions on Au, Nal, and Cu. We have verified the Agodi's prediction for the first time over the wide mass region. This suggests that (polarized gamma, n) reactions may be useful tools to study M1 strengths in giant resonance regions.

  10. Scenari valutativi delle politiche strutturali e nazionali in ambito urbano: l’esperienza della Regione Abruzzo

    Directory of Open Access Journals (Sweden)

    Barbara Ferri

    2012-03-01

    Full Text Available Le politiche urbane e del territorio vivono una fase di profonda trasformazione, caratterizzata dal passaggio a nuovi approcci e nuovi strumenti operativi. Alla chiusura di un periodo caratterizzato sul piano strategico dall’esigenza di superare la rigidità del piano urbanistico, cui è corrisposta sul piano operativo un’estrema frammentarietà degli strumenti e delle tipologie di intervento, fa oggi seguito, dietro la spinta dell’impulso della politica urbana europea e di nuove esigenze per il finanziamento degli interventi legate alla carenza di risorse pubbliche, una fase di ripensamento complessivo della strategia e degli strumenti operativi. Le nuove politiche per il territorio pongono due temi centrali: le Piattaforme Territoriali strategiche individuate dal Ministero delle Infrastrutture come stimolo ed opportunità per le Regioni di elaborare loro ipotesi interpretative del territorio, ed i Piani strategici delle città, le quali risultano identificate come luoghi di concentrazione delle potenzialità e delle eccellenze, motori dello sviluppo territoriale in chiave competitiva. Tali tematiche pongono la necessità – per progetti ad elevata complessità – di ampliare l’orizzonte delle analisi valutative, cercando di cogliere “se e in che misura” gli effetti prodotti sul territorio siano tali da incidere sullo sviluppo complessivo delle città. In tal senso, per un effettivo impiego della valutazione ai fini della programmazione, si propone una maggiore attenzione per un uso critico della accountability e si riportano alcune considerazioni scaturite da approfondimenti specifici di carattere metodologico su recenti documenti emanati dalla Commissione Europea per il periodo 2007- 13. Il lavoro offre un inquadramento generale della politica urbana regionale e dei relativi strumenti operativi implementati in Abruzzo nel corso dell’ultimo decennio, e cofinanziati dai Fondi Strutturali e Nazionali (FAS. Le criticità emerse in

  11. Oligopolios mixtos, privatización e integración regional

    Directory of Open Access Journals (Sweden)

    José Méndez Naya

    2008-01-01

    Full Text Available Partiendo de un modelo sencillo de oligopolio internacional mixto, en que los países pueden aplicar aranceles discriminatorios, se analizan los efectos en las variables relevantes derivados de los procesos de privatización y liberación regional de la economía. En concreto se justifica, desde un punto de vista teórico, la evidencia empírica que nos muestra que los procesos de liberación regional de la economía y la privatización de las empresas públicas son procesos complementarios.

  12. E-health: Determinants, opportunities, challenges and the way forward for countries in the WHO African Region

    Directory of Open Access Journals (Sweden)

    Gatwiri Doris

    2005-12-01

    Full Text Available Abstract Background The implementation of the 58th World Health Assembly resolution on e-health will pose a major challenge for the Member States of the World Health Organization (WHO African Region due to lack of information and communications technology (ICT and mass Internet connectivity, compounded by a paucity of ICT-related knowledge and skills. The key objectives of this article are to: (i explore the key determinants of personal computers (PCs, telephone mainline and cellular and Internet penetration/connectivity in the African Region; and (ii to propose actions needed to create an enabling environment for e-health services growth and utilization in the Region. Methods The effects of school enrolment, per capita income and governance variables on the number of PCs, telephone mainlines, cellular phone subscribers and Internet users were estimated using a double-log regression model and cross-sectional data on various Member States in the African Region. The analysis was based on 45 of the 46 countries that comprise the Region. The data were obtained from the United Nations Development Programme (UNDP, the World Bank and the International Telecommunications Union (ITU sources. Results There were a number of main findings: (i the adult literacy and total number of Internet users had a statistically significant (at 5% level in a t-distribution test positive effect on the number of PCs in a country; (ii the combined school enrolment rate and per capita income had a statistically significant direct effect on the number of telephone mainlines and cellular telephone subscribers; (iii the regulatory quality had statistically significant negative effect on the number of telephone mainlines; (iv similarly, the combined school enrolment ratio and the number of telephone mainlines had a statistically significant positive relationship with Internet usage; and (v there were major inequalities in ICT connectivity between upper-middle, lower-middle and

  13. Eventi e modi del morire nelle strutture sanitarie di degenza della regione Piemonte

    Directory of Open Access Journals (Sweden)

    C. Silvestre

    2003-05-01

    Full Text Available

    L’ospedale per acuti è il luogo meno adatto ad accogliere il malato in fase avanzata, sia per il modello organizzativo, sia perché progettato per guarire. Poco si sa su come il paziente affetto da patologie in fase terminale muoia in ospedale, sui problemi che incontra e sul tipo di assistenza che riceve. Questo lavoro replica per il Piemonte lo studio EOLO, già svolto in Lombardia, Umbria e negli ospedali della provincia di Firenze nel 2002.

    Obiettivi: descrivere le modalità con cui si muore in ospedale (circostanze, interventi/trattamenti attivati. Valutare se esiste un diverso approccio clinicoassistenziale tra pazienti il cui decesso era un evento atteso o improvviso. Metodi: lo studio è di natura osservazionale (2003 e riguarda gli ospedali pubblici e/o convenzionati del Piemonte con un numero di ricoveri/anno › 8.000. I dati dei pazienti sono stati raccolti in sette giornate di osservazione (compresi sabato e domenica, su tutti i malati deceduti per qualsiasi motivo, tramite intervista ad hoc all’infermiere ed al medico responsabili dell’assistenza, consultazione delle cartella clinica ed infermieristica. Sono esclusi i pazienti deceduti entro 24 ore dal ricovero, i malati di età pediatrica, i reparti di Pronto soccorso, Rianimazione, UTIC e DEA. Le schede sono anonime, i dati vengono raccolti da personale interno all’ospedale.

    Risultati attesi: quadro epidemiologico e qualitativo dei casi di morte in ospedale. Epidemiologia dei trattamenti clinici ed assistenziali erogati. Descrizione delle eventuali differenze di decision making tra pazienti il cui decesso è atteso o non atteso. Descrizione delle condizioni e degli eventi (tipo di stanza, assistenza di base, presenza dei parenti che accompagnano la morte del paziente in ospedale.

    Conclusioni: i pazienti oncologici e non continuano a morire in ospedale. Si conosce molto poco di

  14. Impact of E4 Training and Field Auditing of GSA Heartland Region Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, Nicholas; Gowri, Krishnan; Underhill, Ronald M.; Goddard, James K.

    2012-04-01

    To assess the impact of energy efficiency expert evaluation (E4) training and field audits performed since 2007, the Federal Energy Management Program (FEMP) undertook a follow-up study on the implementation of E4 recommendations and an analysis of energy savings. The building property manager and O and M contractor of each facility were interviewed to obtain feedback and implementation status of the E4 recommendations. Overall, there were more than 160 recommendations documented in the E4 reports; about 50% of these recommendations were fully implemented and the remaining 50% either partially implemented or not implemented. In four buildings, the E4 recommendations were aligned with American Recovery and Reinvestment Act of 2009 (ARRA) projects replacing HVAC equipment or upgrading the building control system. The E4 recommendations were not followed-up in two buildings because of uncertainty of the long-term use of the facility or personnel changes. Results of this followon study are reported in this document.

  15. DRIVERS OF E-GOVERNMENT MATURITY IN TWO DEVELOPING REGIONS: FOCUS ON LATIN AMERICA AND SUB-SAHARAN AFRICA

    Directory of Open Access Journals (Sweden)

    Princely Ifinedo

    2012-04-01

    Full Text Available This research focuses on the determinants of e-government (E-gov maturity in two comparable regions of the world i.e. Latin America and Sub-Saharan Africa (LA&SSA. E-gov maturity refers to the growth levels in a country’s online services and its citizens’ online participation in governance. To date, few researchers have focused on the determinants of E-gov maturity in LA&SSA. Given the challenges faced by LA&SSA with regard to the implementations and deployment of technological innovations including E-gov, research such as this current one is needed to enrich insight in such contexts. Building on a prior framework and the modernization theory, the impacts of macro-environmental factors of political, economic, social, and technological dimensions on E-gov maturity in LA&SSA are examined. A 5-year panel data consisting of 160 observations or data points was used for analysis in conjunction with structural equation modeling. The data analysis underscored the pertinence of some of the factors on E-gov maturity in LA&SSA. The implications of the study’s findings for research and policy making are discussed.

  16. Projeto e análise de uma roda em fibra de carbono de um jato regional.

    OpenAIRE

    Rodrigo Borin

    2008-01-01

    Esta dissertação apresenta o projeto preliminar e a análise estrutural por elementos finitos de uma roda em fibra de carbono com perfil aerodinâmico de uma aeronave da categoria jato regional, juntamente com seus componentes, como rolamentos e chavetas de transmissão de força de frenagem. Será descrito o perfil aerodinâmico das hélices, assim como a geometria da roda e os materiais selecionados. Considerações térmicas e aerodinâmicas a respeito da roda também serão levadas em conta, assim com...

  17. Venezuela e ALBA: regionalismo contra-hegemônico e ensino superior para todos Venezuela and the ALBA: counter-hegemonic regionalism and higher education for all

    Directory of Open Access Journals (Sweden)

    Thomas Muhr

    2010-08-01

    Full Text Available Partindo de um quadro teórico neo-gramsciano crítico à globalização, este artigo aplica a nova teoria do regionalismo (NTR e a teoria do regionalismo regulatório (TRR à sua análise e teorização dos tratados de comércio da Aliança Bolivariana para os Povos da Nossa América (ALBA-TCP como regionalismo contra-hegemônico na América Latina e Caribe (ALC. A ALBA está centrada na ideia de um Socialismo do Século XXI, que, como (inicialmente também a Revolução Bolivariana da Venezuela, substitui a 'vantagem competitiva' pela 'vantagem cooperativa'. Em seu caráter de conjunto de processos multidimensionais e transnacionais a ALBA-TCP opera dentro de/transversalmente a um número de setores e escalas, ao mesmo passo que as transformações estruturais são movidas pela interação de agentes do Estado e agentes não estatais. A política de Educação Superior para Todos (ESPT do governo venezuelano rejeita a agenda neoliberal globalizada de mercadorização, privatização e elitismo e reinvindica educação pública gratuita em todos os níveis como um direito humano fundamental. A ESPT está sendo regionalizado em um espaço educacional emergente da ALBA e assume um papel-chave nos processos de democracia direta e participatória, dos quais a construção popular (bottom-up da contra-hegemonia e a redefinição política e econômica da ALC dependem. Antes de produzir sujeitos empreendedores conformes ao capitalismo global, a ESPT procura formar subjetividades ao longo de valores morais de solidariedade e cooperação. Isso será ilustrado com referência a um estudo etnográfico de caso da Universidade Bolivariana da Venezuela (UBV.This paper employs new regionalism theory and regulatory regionalism theory in its analysis and theorisation of the Bolivarian Alliance for the Peoples of Our America (ALBA as a counter-hegemonic Latin American and Caribbean (LAC regionalism. As (initially the regionalisation of Venezuela's Bolivarian

  18. Characteristics of the Clinical Course of Autochthonous Hepatitis E in the Central Region of Russia

    Directory of Open Access Journals (Sweden)

    E. Yu. Malinnikova

    2013-01-01

    Full Text Available The records of total 123 patients with hepatitis E on treatment in the infectious diseases hospital in the city of Belgorod were reviewed. Diagnosis – «acute hepatitis E» was based on the generally accepted criteria: biochemical analysis, etiological interpretation (identification of antibodies to hepatitis E of the IgM and IgG, HEV RNA with the exception of the etiologic role of other hepatotropic viruses, including Epstein-Barr virus and cytomegalovirus. HEV RNA was determined by PCR, genotyping was performed by standard methods based on the results of sequencing. The study of clinical manifestations in patients with acute hepatitis E allowed to establish some specific features of hepatitis E: predominantly occurrence in adults at the age 30 years and more; frequent complaints of arthralgia in the prejaundice period, the lack of improvement after jaundice development; pronounced dyspeptic symptoms and long bilirubinemia combined with mild transaminase elevation, hepatomegaly with no concomitant increase in the spleen. The data on the fulminant forms of hepatitis E are presented. Herein we describe the case of fulminant course of infection with a fatal outcome. Analysis of cases of severe hepatitis E have revealed the following risk factors: heart disease, chronic biliary disease, obesity, diabetes mellitus, chronic alcohol intoxication. The analysis of specific clinical manifestations of this infection is needed to select the right strategy of patient following, to set integrated differential diagnostic approach in the management of patients with middle and old age with the presence of jaundice and patients with hepatitis of unknown etiology. The inclusion of hepatitis E markers to the diagnostic algorithm is necessary for such patients.

  19. Cultivando sociologias públicas nos terrenos nacional, regional e global

    Directory of Open Access Journals (Sweden)

    Michael Burawoy

    2009-10-01

    Full Text Available Neste artigo o autor discute a posição do sociólogo e dos cientistas sociais como "intelectuais", cuja inserção política e institucional é variada, podendo ser profissional, crítica, pública ou voltada para políticas públicas. Em contraposição a um ideal wallersteiniano - de acordo com o qual o intelectual, por um lado, está mais próximo das camadas populares e mais distante do poder e, por outro lado, tem uma responsabilidade ao mesmo tempo analítica, moral e política -, o autor considera que os cientistas sociais podem adotar apenas uma dessas dimensões de cada vez, mas que as trocas entre os gêneros da prática sociológica integram, de maneira positiva, a sua dinâmica profissional. O artigo tem a seguinte estrutura: 1 situa o sociólogo no contexto da sua prática, dando especial atenção ao caráter disciplinar vigente; 2 o qual é ele próprio conformado por diferentes regimes políticos nacionais; 3 para finalmente tratar do âmbito global. A conclusão geral é que os sociólogos não orbitam em um espaço vazio além da economia, mas cumprem suas missões em terrenos ideológico e político, que são locais e nacionais antes de constituírem-se como globais. Reconhecer esses terrenos é a primeira tarefa para qualquer engajamento crítico ou projeto político, pois eles constituem os tijolos de qualquer Sociologia internacional.

  20. Incentivi fiscali e politiche di sviluppo economico regionale in Europa (Fiscal Incentives and Regional Economics Development Policies in Europe

    Directory of Open Access Journals (Sweden)

    Beniamino Moro

    2012-04-01

    Full Text Available The paper shows that fiscal policy and tax incentives are more effective than monetary policy and monetary incentives in supporting a regional development policy among European regions. Anyway, only recently the EU Commission agreed that member countries can use tax incentives instead of monetary ones to support new investment in European less developed areas, but she still does not permit that a member state can apply a differentiated fiscal policy on a regional basis. In fact, according to the Commission, a reduced tax rate for growth purposes in European less developed areas has the same effect as a working aid for those firms located in these areas, which is forbidden by the Code of conduct that regulates fiscal competition among member states. The paper shows this interpretation is not correct and also demonstrates that a regional fiscal policy differentiated among areas inside the same member state can be supported without violate the sound principles of fiscal free competition incorporated in the Code of Conduct.         JEL Codes: E62, R58Keywords: Fiscal Policy, Policy, Regional Development, Regional, Tax

  1. Conceptualizing the foundations of a regional e-commerce strategy: Open networks or closed regimes? The case of CARICOM

    Directory of Open Access Journals (Sweden)

    Pearson A. Broome

    2016-12-01

    Full Text Available Although there has been much to boast about in advanced countries regarding e-commerce as a viable business strategy, many doubt its application to developing countries. Several papers examine individual case studies from advanced developing countries but few have presented a systemic focus on the ecosystem of an e-commerce sector, and even fewer on small island developing states (SIDS such as the Caribbean, and those often lack a comprehensive awareness of the sector, and/or are dated. The central aim of this conceptual paper therefore is to address this lacuna by discussing the importance of understanding the broader political, social, cognitive, and economic issues and their implications and applications inherent in the development of an e-commerce sector. From this, the main objective will be to conceptualize an e-commerce strategy for their development. To realize this main aim, the article leverages a historical comparative perspective that critically examines causal analysis, experiences, and iterative processes gleaned over time from a structured analytical comparison of several national and regional case studies to conceptualize the factors and conditions under which e-commerce may contribute to, and can be adopted for development. As its main objective, the paper then presents a policy framework of recommendations guided by mutually reinforcing macro processes of change that converge at the intersection of business, policy, and information technology to inform development advocates, policy planners, and citizens within the region of what such a strategy should entail.

  2. Tracking the Global Distribution of Persistent Organic Pollutants Accounting for E-Waste Exports to Developing Regions.

    Science.gov (United States)

    Breivik, Knut; Armitage, James M; Wania, Frank; Sweetman, Andrew J; Jones, Kevin C

    2016-01-19

    Elevated concentrations of various industrial-use Persistent Organic Pollutants (POPs), such as polychlorinated biphenyls (PCBs), have been reported in some developing areas in subtropical and tropical regions known to be destinations of e-waste. We used a recent inventory of the global generation and exports of e-waste to develop various global scale emission scenarios for industrial-use organic contaminants (IUOCs). For representative IUOCs (RIUOCs), only hypothetical emissions via passive volatilization from e-waste were considered whereas for PCBs, historical emissions throughout the chemical life-cycle (i.e., manufacturing, use, disposal) were included. The environmental transport and fate of RIUOCs and PCBs were then simulated using the BETR Global 2.0 model. Export of e-waste is expected to increase and sustain global emissions beyond the baseline scenario, which assumes no export. A comparison between model predictions and observations for PCBs in selected recipient regions generally suggests a better agreement when exports are accounted for. This study may be the first to integrate the global transport of IUOCs in waste with their long-range transport in air and water. The results call for integrated chemical management strategies on a global scale.

  3. Artificial E-region field-aligned plasma irregularities generated at pump frequencies near the second electron gyroharmonic

    Directory of Open Access Journals (Sweden)

    D. L. Hysell

    2009-07-01

    Full Text Available E region ionospheric modification experiments have been performed at HAARP using pump frequencies about 50 kHz above and below the second electron gyroharmonic frequency. Artificial E region field-aligned plasma density irregularities (FAIs were created and observed using the imaging coherent scatter radar near Homer, Alaska. Echoes from FAIs generated with pump frequencies above and below 2Ωe did not appear to differ significantly in experiments conducted on summer afternoons in 2008, and the resonance instability seemed to be at work in either case. We argue that upper hybrid wave trapping and resonance instability at pump frequencies below the second electron gyroharmonic frequency are permitted theoretically when the effects of finite parallel wavenumbers are considered. Echoes from a sporadic E layer were observed to be somewhat weaker when the pump frequency was 50 kHz below the second electron gyroharmonic frequency. This may indicate that finite parallel wavenumbers are inconsistent with wave trapping in thin sporadic E ionization layers.

  4. Evidence for VHE emission from SNR G22.7-0.2 region with H.E.S.S

    CERN Document Server

    Laffon, Hélène; Brun, Francois; Acero, Fabio; Méhault, Jérémie; Pühlhofer, Gerd; Eger, Peter; Jamrozy, Marek; Djannati-Ataï, Arache; Clapson, Andre-Claude

    2011-01-01

    Observations of the supernova remnant G22.7-0.2 in the field of view of W41 with the H.E.S.S. telescope array have resulted in evidence for a very high energy (VHE) gamma-ray emission from the direction of the object. The emission region is spatially coincident with molecular clouds visible in 13CO data, suggesting a hadronic origin of the TeV emission, although other scenarios brought by X-ray observations with the XMM-Newton satellite are also discussed. The latest results obtained on this SNR with H.E.S.S. and associated multi-wavelength information are presented here.

  5. SEGURANÇA REGIONAL NO CHIFRE DA ÁFRICA: CONFLITOS, AGENDAS E AMEAÇAS

    Directory of Open Access Journals (Sweden)

    Nilton César Fernandes Cardoso

    2017-01-01

    Full Text Available Este artigo tem por objetivo analisar a dinâmica de segurança no Chifre da África no período pós-independência, identificando os atores, agendas e ameaças. Para tanto, ele se divide em três partes. Na primeira parte, faz-se uma análise da dinâmica de segurança no Chifre da África durante o período da Guerra Fria, focando-se nas rivalidades regionais e na penetração das potências extrarregionais. Na segunda parte são discutidas as transformações ocorridas na região no imediato pós-Guerra Fria, focando nas dinâmicas de segurança internas das unidades (Estados e regionais. Por fim, a última parte busca identificar as “novas” ameaças e as repostas internacionais e regionais, bem como a nova importância estratégica da região para as potências tradicionais no pós-11 de setembro de 2001 consumado no processo de securitização.

  6. Sequence variation of koala retrovirus transmembrane protein p15E among koalas from different geographic regions.

    Science.gov (United States)

    Ishida, Yasuko; McCallister, Chelsea; Nikolaidis, Nikolas; Tsangaras, Kyriakos; Helgen, Kristofer M; Greenwood, Alex D; Roca, Alfred L

    2015-01-15

    The koala retrovirus (KoRV), which is transitioning from an exogenous to an endogenous form, has been associated with high mortality in koalas. For other retroviruses, the envelope protein p15E has been considered a candidate for vaccine development. We therefore examined proviral sequence variation of KoRV p15E in a captive Queensland and three wild southern Australian koalas. We generated 163 sequences with intact open reading frames, which grouped into 39 distinct haplotypes. Sixteen distinct haplotypes comprising 139 of the sequences (85%) coded for the same polypeptide. Among the remaining 23 haplotypes, 22 were detected only once among the sequences, and each had 1 or 2 non-synonymous differences from the majority sequence. Several analyses suggested that p15E was under purifying selection. Important epitopes and domains were highly conserved across the p15E sequences and in previously reported exogenous KoRVs. Overall, these results support the potential use of p15E for KoRV vaccine development. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. OECD eXplorer: Making Regional Statistics Come Alive through a Geo-Visual Web-Tool

    Directory of Open Access Journals (Sweden)

    Monica Brezzi

    2011-06-01

    Full Text Available Recent advances in web-enabled graphics technologies have the potential to make a dramatic impact on developing highly interactive Geovisual Analytics applications for the Internet. An emerging and challenging application domain is geovisualization of regional (sub-national statistics. Higher integration drivenby institutional processes and economic globalisation is eroding national borders and creating competition along regional lines in the world market. Sound information at sub-national level and benchmark of regions across borders have gained importance in the policy agenda of many countries. In this paper, we introduce “OECD eXplorer” — an interactive tool for analyzing and communicating gained insights and discoveries about spatial-temporal and multivariate OECD regional data. This database is a potential treasure chest for policy-makers, researchers and citizens to gain a better understanding of a region’s structure and performance and to carry out analysis of territorial trends and disparities based on sound information comparableacross countries. Many approaches and tools have been developed in spatial-related knowledge discovery but generally they do not scale well with dynamic visualization of larger spatial data on the Internet. In this context, we introduce a web-compliant Geovisual Analytics toolkit that supports a broad collection offunctional components for analysis, hypothesis generation and validation. The same tool enables the communicationof results on the basis of a snapshot mechanism that captures, re-uses and shares task-related explorative findings. Further developments underway are in the creation of a generic highly interactive web “eXplorer” platform that can be the foundation for easy customization of similar web applications usingdifferent geographical boundaries and indicators. Given this global dimension, a “generic eXplorer” will be a powerful tool to explore different territorial dimensions

  8. Música popular nas rádios do ABC: memória musical e cultura regional nos anos 1950 e 1960

    Directory of Open Access Journals (Sweden)

    Herom Vargas

    2008-11-01

    Full Text Available Aliança entre os estudos midiáticos e os relacionados à memória podem oferecer novas perspectivas para o entendimento da cultura e de suas relações com os meios de comunicação, seja em âmbito local ou em dimensões mais amplas. Tendo em vista as atuais relações entre memória social e comunicação, este artigo pretende analisar a produção musical popular na região do Grande ABC paulista sob o ponto de vista da memória de alguns de seus personagens, colocando em destaque o papel de quatro emissoras de rádio locais como mediadoras culturais entre gêneros musicais mais tradicionais e a sociedade local. Discute-se a produção local de canções de gêneros tradicionais, como o samba-canção, o bolero, a valsa e a canção sertaneja, a partir da análise dos relatos de histórias de vida de músicos e compositores que viveram o período na região e, também, da análise de suas canções, a fim de pensar como as transformações culturais locais mantêm ou modificam essa produção musical local e identificam o papel do rádio na difusão desses gêneros musicais na região nessa época. Palavras-chave: memória; rádio; música popular; região do ABC Abstract Pop music on the ABC radios: musical memory and regional culture in the 50s and 60s - Combining media and memory-related studies may offer new perspectives for understanding culture and its relations with the communication media, both local and from a broader standpoint. In view of the current relations between social memory and communication, this article analyzes the production of popular music in the Greater São Paulo ABC region from the point of view of its more traditional songs, highlighting the role of four local radio stations as cultural mediators between traditional musical genres and the local society. The local production of traditional musical genres is discussed, based on an analysis of the lives of musicians and composers who lived in the region in

  9. Public-Privat e Partnership in the System of Regional Healthcare Financing

    Directory of Open Access Journals (Sweden)

    Margarita Yur’evna Molchanova

    2016-05-01

    Full Text Available Healthcare financing reform in the Russian Federation, besides its positive consequences, has led to the emergence of several major organizational and economic problems that hinder the expansion of financing sources for this sphere, which also involves public-private partnership (PPP. The paper highlights the regional specifics of such healthcare projects compared to similar projects of other spheres of the national economy. The author describes the problems of PPP projects implementation in healthcare; they include the insufficiency of substantiation of public-private partnership application in healthcare, and the absence of typical models for establishment of relations between PPP participants. The paper presents the healthcare priorities put forward by the author; these priorities are based on the theory of the life cycle of a service. The author presents her own model for organizing a regional concession, which is the most common form of public-private partnership in healthcare so far. The cluster brings together on a voluntary basis the legally independent organizations that are interested in improving the quality and increasing the accessibility of health services. These can include medical institutions of various forms of ownership located in the region, clinics, facilities, institutions that train healthcare workers, authorities, etc. The author shows that a favorable environment for the formation and implementation of PPP projects can be created under the cluster approach to the organization of healthcare. When establishing the medical cluster, the main task is to organize interaction between all its subjects in the interest of the overall development of healthcare in the region and the implementation of one’s own interests

  10. Causas de hipocromia e microcitose em dadores de sangue do Centro Regional de Sangue de Coimbra

    OpenAIRE

    Bogas, Mário Luís de Sousa Basto

    2009-01-01

    A hemoglobina é um polipeptido em forma de tetrâmero, constituído por um grupo heme e por dois pares de cadeias globínicas α (ζ, α1, α2) e não-α (β, δ, Aγ, Gγ, ε) que se associam em diversas combinações formando diferentes hemoglobinas. Nos adultos, a príncipal hemoglobina sintetizada é a HbA (α2β2), contribuindo para cerca de 95% do total da hemoglobina. A restante hemoglobina é constituída por pequenas quantidades de Hb A2 (α2δ2) (

  11. Optical Oscillator Strengths of Hydrogen Bromide in the 4.5-20 eV Excitation Energy Region

    Institute of Scientific and Technical Information of China (English)

    李文斌; 朱林繁; 刘小井; 苑震生; 孙建敏; 成华东; 徐克尊

    2004-01-01

    The absolute optical oscillator strength density spectrum of HBr in the valence shell energy region of 4.5-20 eV has been determined by a high-resolution fast electron energy loss spectrometer. The optical oscillator strengths reported. It has been manifested clearly that the optical oscillator strengths of some transitions for the previous photoabsorption method are subject to severe line-saturation effects.

  12. Optical Oscillator Strengths of Hydrogen Chloride in the Energy Region of 5.5-20 eV

    Institute of Scientific and Technical Information of China (English)

    李文斌; 朱林繁; 刘小井; 苑震生; 孙建敏; 成华东; 酒井康弘; 徐克尊

    2003-01-01

    Absolute optical oscillator strength density (OOSD) spectrum of HCl in the valence shell energy region of 5.5-20 eV has been determined by the high resolution fast electron energy loss spectrometer (EELS). The optical oscillator strengths for the broad A1Ⅱ + 13∑+ dissociation peak and the discrete transitions of b3Ⅱ(v′=0),C1Ⅱ(v′ = 0, 1, 2) and M1Ⅱ(v′= 0) are reported.

  13. Parallel electron streaming in the high-latitude E region and its effect on the incoherent scatter spectrum

    Science.gov (United States)

    Bahcivan, H.; Cosgrove, R. B.; Tsunoda, R. T.

    2006-07-01

    This article investigates the combined electron heating and streaming effects of low-frequency parallel electric fields on the incoherent scatter measurements of the high-latitude E region. The electric fields distort the electron distribution function, inducing changes on the amplitude and frequency of the ion-acoustic line in the measured incoherent scatter spectrum. If one assumes Maxwellian electrons, the measurements of electron and ion temperatures and electron density are subject to significant percentage errors during geomagnetically active conditions.

  14. [Helminths of hedgehogs, Erinaceus europaeus and E. roumanicus from Poznań region, Poland--coprological study].

    Science.gov (United States)

    Mizgajska-Wiktor, Hanna; Jarosz, Wojciech; Piłacińska, Barbara; Dziemian, Sylwia

    2010-01-01

    Fecal samples from the hedgehogs, Erinaceus europaeus (15 samples) and E. roumanicus (44 samples) collected in the Poznań region of Poland were examined. Endoparasites were isolated using Sheather's flotation technique. The prevalence of parasitic infections in all hedgehogs examined was 74.6% (E. europaeus--73.3%; E. roumanicus--75.0%). Two species of parasites occurred in both species of hosts: Aonchotheca erinacei (60% and 80%) and Eucoleus aerophilus (6.7% and 15.9%). Brachylaima erinacei was found only in E. europaeus (33.3%) while Physaloptera sp. (13.6%) and Crenosoma striatum (4.6%) only in E. roumanicus. The intensity of infection varied from 1 to 371 eggs/1g of feces in E. europaeus and from 1 to 194 eggs/1g of feces in E. roumanicus. In both sexes the majority of infections were of low intensity, high intensity infections occurring only sporadically. No zoonotic species of endoparasites were recorded in these samples.

  15. Planetary wave signatures in the equatorial atmosphere ionosphere system, and mesosphere- E- and F-region coupling

    Science.gov (United States)

    Abdu, M. A.; Ramkumar, T. K.; Batista, I. S.; Brum, C. G. M.; Takahashi, H.; Reinisch, B. W.; Sobral, J. H. A.

    2006-02-01

    Upward transport of wave energy and momentum due to gravity, tidal and planetary waves from below and extra-tropics controls the phenomenology of the equatorial atmosphere ionosphere system. An important aspect of this phenomenology is the development of small- and large-scale structures including thin layers in the mesosphere and E-region, and the formation of wide spectrum plasma structures of the equatorial F-region, widely known as equatorial spread F/plasma bubble irregularities (that are known to have significant impact on space application systems based on trans-ionospheric radio waves propagation). It seems that the effects of tidal and gravity waves at mesospheric and thermospheric heights and their control of ionospheric densities, electric fields and currents are relatively better known than are the effects originating from vertical coupling due to planetary waves. Results from airglow, radar and ionospheric sounding observations demonstrate the existence of significant planetary wave influence on plasma parameters at E- and F-region heights over equatorial latitudes. We present and discuss here some results showing planetary wave oscillations in concurrent mesospheric winds and equatorial electrojet intensity variations in the Indian sector as well as in the mesospheric airglow and F-layer height variation in Brazil. Also presented are evidences of planetary wave-scale oscillations in equatorial evening pre-reversal electric field (F-region vertical drift) and their effects on equatorial spread F /plasma bubble irregularity development and day-to-day variability.

  16. High resolution analysis of the chromatin landscape of the IgE switch region in human B cells.

    Directory of Open Access Journals (Sweden)

    Sandeep Dayal

    Full Text Available Antibodies are assembled by a highly orchestrated series of recombination events during B cell development. One of these events, class switch recombination, is required to produce the IgG, IgE and IgA antibody isotypes characteristic of a secondary immune response. The action of the enzyme activation induced cytidine deaminase is now known to be essential for the initiation of this recombination event. Previous studies have demonstrated that the immunoglobulin switch regions acquire distinct histone modifications prior to recombination. We now present a high resolution analysis of these histone modifications across the IgE switch region prior to the initiation of class switch recombination in primary human B cells and the human CL-01 B cell line. These data show that upon stimulation with IL-4 and an anti-CD40 antibody that mimics T cell help, the nucleosomes of the switch regions are highly modified on histone H3, accumulating acetylation marks and tri-methylation of lysine 4. Distinct peaks of modified histones are found across the switch region, most notably at the 5' splice donor site of the germline (I exon, which also accumulates AID. These data suggest that acetylation and K4 tri-methylation of histone H3 may represent marks of recombinationally active chromatin and further implicates splicing in the regulation of AID action.

  17. Evaluation of methylation pattern in promoter region of E-cadherin ...

    African Journals Online (AJOL)

    user

    2011-03-07

    Mar 7, 2011 ... promoter methylation in CDH1 gene inactivation in breast cancer, the CpG methylation status of E- cadherin promoter ... The data indicate that CDH1 promoter methylation might be a potential ... Complex genetic and epigenetic alterations affect the ... DNA methylation is the covalent addition of a methyl.

  18. Scenario building for E-Government in 2020: Consolidating the results from regional workshops

    NARCIS (Netherlands)

    Janssen, M.F.W.H.A.; Van der Duin, P.; Wagenaar, R.W.; Bicking, M.; Wimmer, M.A.; Dawes, S.; Petrauskas, R.

    2007-01-01

    E-government research is currently at a stage of consolidation and new orientation. Smaller steps of government modernization have in part been successfully implemented; larger ones still lie ahead of us. Within an EC funded project, a roadmap for egovernment is being defined. Thereby, scenario buil

  19. O global e o regional: a experiência de desenvolvimento no Maranhão contemporâneo

    Directory of Open Access Journals (Sweden)

    Zulene Muniz Barbosa

    2013-04-01

    Full Text Available O objetivo neste artigo é examinar o modo como o desenvolvimento global e o regional se articulam e se materializam numa formação concreta como a do Maranhão. Com vistas a apreender a atuação do Estado burguês, no plano nacional e regional, num contexto marcado por determinações de caráter transnacional, examinam-se suas relações com grandes empreendimentos econômicos. Nesse processo, tem sido decisiva a participação das oligarquias regionais, interessadas em reforçar seus interesses políticos, colocando-se a serviço da integração da economia regional ao sistema capitalista internacional como mediadoras de acordos entre o governo brasileiro e grandes empresas transnacionais (japonesa e estadunidense. Iniciativas como essas, envolvendo planejamento governamental e capital privado, têm provocado profundos impactos socioambientais, alterando biomas e modos de vida de populações locais. Passados 30 anos da instalação do Projeto Grande Carajás, o Maranhão continua sendo um dos estados mais pobres do Brasil, exibindo indicadores sociais baixíssimos, mas altíssimos índices de concentração de terras, riquezas e poder político.Palavras-chave | Desenvolvimento regional; empresas transnacionais; globalização; Projeto Grande Carajás; Maranhão.Código JEL | O18; R11; R58. THE GLOBAL AND THE REGIONAL: THE DEVELOPMENT EXPERIENCE IN CONTEMPORARY MARANHÃOAbstractThe purpose of this article is to examine how the global and regional development articulate and materialize as a concrete formation as the one in the state of Maranhão. In order to grasp the role of the bourgeois state, both nationally and regionally, in a context marked by transnational character determinations, we examine its relations with major economic enterprises. In the process, the participation of regional oligarchies has been decisive, which are interested in strengthening their political interests, putting themselves at the service of the integration

  20. Binding labour and capital: moral obligation and forms of regulation in a regional economy Ligando o trabalho e o capital: obrigação moral e formas de regulação numa economia regional

    Directory of Open Access Journals (Sweden)

    Susana Narotzky

    2006-11-01

    Full Text Available The article is a critique of models of successful economic development in Europe based on the "economic region" idea. These models stress the usefulness of embedding economic relations in the social fabric ("social capital". The ethnography reveals, however, a conflict-laden space where increased embeddedness produces increased tension within the family and the community. In this "modelic" regional economy in Southern Alicante (Spain, recent violent events have involved local actors in the shoe-wear industry, with resident Chinese entrepreneurs. I will show how this confrontation underlines the rise of local modalities of conflict that build upon the organic and culturally bounded elements of economic production that the model stresses: local homogeneity and common interest. The ethnographic evidence shows the complexity of a "regional economy" in a globalized context where appeals to the State to strengthen and enforce some regulations coexist with appeals to de-regulate other areas of the economy.Este artigo é uma crítica aos modelos de sucesso de desenvolvimento económico na Europa baseados na ideia de "região económica". Estes modelos acentuam a utilidade do encastramento das relações económicas no tecido social ("capital social". No entanto, a etnografia mostra-nos um espaço de conflito onde um crescente encastramento produz um aumento da tensão na família e na comunidade. Nesta economia regional "modelar" do sul de Alicante (Espanha, episódios recentes de violência envolveram actores locais da indústria do calçado com empresários chineses aí residentes. Mostrarei como este confronto ilustra o surgimento de modalidades locais de conflito que se exprimem na base dos elementos orgânicos e de enraizamento cultural da produção económica sublinhados pelo modelo: a homogeneidade local e o interesse comum. A investigação etnográfica mostra a complexidade da "economia regional" num contexto globalizado, onde apelos dirigidos

  1. Acetylcholinesterase (AChE) gene modification in transgenic animals: functional consequences of selected exon and regulatory region deletion.

    Science.gov (United States)

    Camp, Shelley; Zhang, Limin; Marquez, Michael; de la Torre, Brian; Long, Jeffery M; Bucht, Goran; Taylor, Palmer

    2005-12-15

    AChE is an alternatively spliced gene. Exons 2, 3 and 4 are invariantly spliced, and this sequence is responsible for catalytic function. The 3' alternatively spliced exons, 5 and 6, are responsible for AChE disposition in tissue [J. Massoulie, The origin of the molecular diversity and functional anchoring of cholinesterases. Neurosignals 11 (3) (2002) 130-143; Y. Li, S. Camp, P. Taylor, Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene. J. Biol. Chem. 268 (8) (1993) 5790-5797]. The splice to exon 5 produces the GPI anchored form of AChE found in the hematopoietic system, whereas the splice to exon 6 produces a sequence that binds to the structural subunits PRiMA and ColQ, producing AChE expression in brain and muscle. A third alternative RNA species is present that is not spliced at the 3' end; the intron 3' of exon 4 is used as coding sequence and produces the read-through, unanchored form of AChE. In order to further understand the role of alternative splicing in the expression of the AChE gene, we have used homologous recombination in stem cells to produce gene specific deletions in mice. Alternatively and together exon 5 and exon 6 were deleted. A cassette containing the neomycin gene flanked by loxP sites was used to replace the exon(s) of interest. Tissue analysis of mice with exon 5 deleted and the neomycin cassette retained showed very low levels of AChE expression, far less than would have been anticipated. Only the read-through species of the enzyme was produced; clearly the inclusion of the selection cassette disrupted splicing of exon 4 to exon 6. The selection cassette was then deleted in exon 5, exon 6 and exons 5 + 6 deleted mice by breeding to Ella-cre transgenic mice. AChE expression in serum, brain and muscle has been analyzed. Another AChE gene targeted mouse strain involving a region in the first intron, found to be critical for AChE expression in muscle cells [S. Camp, L. Zhang, M. Marquez, B

  2. Factores clave de la competitividad regional: inovación e intangibles

    OpenAIRE

    López García, Ana María; Méndez Alonso, Juan José; Dones Tacero, Milagros

    2009-01-01

    En un mundo globalizado las distintas economías (países, regiones,...) compiten para mantener y mejorar su nivel de vida. La competitividad no es sólo la capacidad de un país para posicionarse en los mercados mundiales, vía exportaciones y atracción de inversiones extranjeras directas, sino también la capacidad de desarrollar un mayor atractivo para empresas locales y extranjeras. Numerosos estudios han centrado sus esfuerzos en encontrar criterios objetivos y cuantificables pa...

  3. Variabilidade local e regional da evapotranspiração estimada pelo algoritmo SEBAL Local and regional variability of evapotranspiration estimated by SEBAL algorithm

    Directory of Open Access Journals (Sweden)

    Luis C. J. Moreira

    2010-12-01

    Full Text Available Em face da importância em conhecer a evapotranspiração (ET para uso racional da água na irrigação no contexto atual de escassez desse recurso, algoritmos de estimativa da ET a nível regional foram desenvolvidos utilizando-se de ferramentas de sensoriamento remoto. Este estudo objetivou aplicar o algoritmo SEBAL (Surface Energy Balance Algorithms for Land em três imagens do satélite Landsat 5, do segundo semestre de 2006. As imagens correspondem a áreas irrigadas, floresta nativa densa e a Caatinga do Estado do Ceará (Baixo Acaraú, Chapada do Apodi e Chapada do Araripe. Este algoritmo calcula a evapotranspiração horária a partir do fluxo de calor latente, estimado como resíduo do balanço de energia na superfície. Os valores de ET obtidos nas três regiões foram superiores a 0,60 mm h-1 nas áreas irrigadas ou de vegetação nativa densa. As áreas de vegetação nativa menos densa apresentaram taxa da ET horária de 0,35 a 0,60 mm h-1, e valores quase nulos em áreas degradadas. A análise das médias de evapotranspiração horária pelo teste de Tukey a 5% de probabilidade permitiu evidenciar uma variabilidade significativa local, bem como regional no Estado do Ceará.In the context of water resources scarcity, the rational use of water for irrigation is necessary, implying precise estimations of the actual evapotranspiration (ET. With the recent progresses of remote-sensed technologies, regional algorithms estimating evapotranspiration from satellite observations were developed. This work aimed at applying the SEBAL algorithm (Surface Energy Balance Algorithms for Land at three Landsat-5 images during the second semester of 2006. These images cover irrigated areas, dense native forest areas and caatinga areas in three regions of the state of Ceará (Baixo Acaraú, Chapada do Apodi and Chapada do Araripe. The SEBAL algorithm calculates the hourly evapotranspiration from the latent heat flux, estimated from the surface energy

  4. Aberrant Methylation of the E-Cadherin Gene Promoter Region in the Endometrium of Women With Uterine Fibroids.

    Science.gov (United States)

    Li, Yan; Ran, Ran; Guan, Yingxia; Zhu, Xiaoxiong; Kang, Shan

    2016-08-01

    A uterine fibroid is a leiomyoma that originates from the smooth muscle layer of the uterus. A variety of endometrial abnormalities are associated with uterine fibroids. This study aims to investigate the methylation status of the E-cadherin gene (CDH1) promoter region in the endometrium of patients with uterine fibroids. The methylation of CDH1 was studied using methylation-specific polymerase chain reaction in the endometrial tissue of 102 patients with uterine fibroids and 50 control patients. The E-cadherin expression was examined by flow cytometry. The methylation rate of CDH1 promoter region was 33.3% in the endometrium of patients with uterine fibroids and 8% in the endometrium of women without fibroids. The frequency of CDH1 promoter methylation in the endometrium of patients with fibroids was significantly higher than that in the endometrium of women without fibroids (P = .001). Furthermore, the E-cadherin expression level in methylation-positive tissues was significantly lower than that in methylation-negative tissues (P = .017). These results suggest that epigenetic aberration of CDH1 may occur in the endometrium of patients with fibroids, which may be associated with E-cadherin protein expression in endometrial tissue.

  5. D- and E-region effects in the auroral zone during a moderately active 24-h period in July 2005

    Directory of Open Access Journals (Sweden)

    J. K. Hargreaves

    2007-08-01

    Full Text Available The effects of energetic electron precipitation into the auroral region at a time of enhanced solar wind have been investigated during a continuous period of 24 h, using the European Incoherent Scatter (EISCAT radar, an imaging riometer, and particle measurements on an orbiting satellite. The relative effects in the E region (120 km and D region (90 km are found to vary during the day, consistent with a gradual hardening of the incoming electron spectrum from pre-midnight to morning. Whereas the night spectra are single peaked, the daytime spectra are found to be double peaked, suggesting the presence of two distinct populations.

    A comparison between the radiowave absorption observed with the riometer and values estimated from the radar data shows generally good agreement, but with some discrepancies suggesting the occurrence of some small-scale features. The height and thickness of the absorbing region are estimated. Two periods of enhanced precipitation and the related radio absorption, one near magnetic midnight and one in the early morning, are studied in detail, including their horizontal structure and movement of the absorption patches.

    A sharp reduction of electron flux recorded on a POES satellite is related to the edge of an absorption region delineated by the imaging riometer. The observed particle flux is compared with a value deduced from the radar data during the overpass, and found to be in general agreement.

  6. Possible experimental studies of the t anti t threshold region at 250--500 GeV e sup + e sup minus collider

    Energy Technology Data Exchange (ETDEWEB)

    Komamiya, Sachio.

    1991-01-01

    A possible measurement of the top quark mass by an energy scan of the t{anti t} threshold region at e{sup +}e{sup {minus}} colliders of {radical}s = 250--500 GeV is discussed. With an integrated luminosity of 1 fb {sup {minus}1} devoted to the energy scan, a top quark mass of about 150 GeV can be determined with an accuracy of {approx}0.3 GeV, with a comparable systematic uncertainty arising from the few % errors in the {alpha}{sub s} measurement at LEP-I. The possibilities of studying {Gamma}{sub t} and Higgs boson effects are also discussed. 10 refs., 12 figs., 4 tabs.

  7. eHealth strategy for the Americas region: current situation and perspectives

    OpenAIRE

    D’Agostino, Marcelo; Organización Panamericana de la Salud, Organización Mundial de la Salud.

    2015-01-01

    The main objective of the Strategy and Plan of Action on eHealth (2012-2017) is to contribute to sustainable developmentof health systems of member states. Its adoption aims to improve quality and access to health services through the use ofinformation and communication technologies (ICT), the implementation of digital literacy programs and access to qualityinformation to advance towards more informed, equitable, competitive and democratic societies. PAHO/WHO considers thatin society, free an...

  8. The Resistance of E.coli in Child Patients in Bingöl Region

    Directory of Open Access Journals (Sweden)

    İlhan Geçit

    2012-07-01

    Full Text Available Aim: In this study, it has been aimed to put forward the resistance of the antibiotic in urinary infections caused by E.coli. Material and Method: The samples of the urine culture sent from 1412 patients who referred to Bingol State Hospital with the suspicion of urinary tract infection between 2007-2011 were retrospectively analyzed. Those who have recently used the antibiotic were excluded from the study. Results: Of the urine cultures sent from 1412 patients with the suspicion of urinary tract infection, there was reproduction in 113 (8%. E.coli was proliferated in 78 patients (69% detected the reproduction in their urine culture. The gender distribution of the patients proliferated E.coli in their urine culture was respectively 13 male (17% and 65 girls (83%. The age range of the children detected the urinary tract infection acquired from the community was under 7 years 39%. The resistance rates of antibiotic for E.coli were found to be 71% for ampicillin, 53% for amoksilin-clavulanate, 51% for co-trimaksazol, 48% for cephalothin, 37% for cefuroxime, 30% for ciprofloxacin, 25% for cefepime, % 21 for norfloxacin, 21% for gentamicin, 6% for sulbactam-seforazom, 2% for amikacin, and 0% for imipenem and meropenem. Discussion: The resistance rates occurring against the antibiotics are getting more and more important because there has been a longer life expectancy in the age group of the children. For this reason, potential uropathogens and antibiotic sensitivities in children should be considered in the treatment by following closely.

  9. CONFIGURAÇÃO TERRITORIAL DO TRANSPORTE AÉREO PAULISTA: NOVAS TERRITORIALIDADES E DESENVOLVIMENTO REGIONAL

    Directory of Open Access Journals (Sweden)

    Ana Paula Camilo Pereira

    2009-12-01

    Full Text Available O transporte aéreo no estado de São Paulo caracteriza-se pela sua expressividade no contexto nacional. Esta área é, atualmente, a que mais gera fluxos econômicos de passageiros e de cargas. É nesse sentido que o presente artigo traz uma análise sobre as condições gerais de produção, enfocando os princípios econômicos de organização do espaço urbano, bem como dos territórios. Assim, têm-se como base central da discussão os princípios de aglomeração, de acessibilidade, de interações espaciais, de hierarquia e de competitividade, a partir de uma contextualização sobre o setor de transporte aéreo. Busca-se demonstrar que a sociedade, baseada na supressão do espaço pelo tempo, requer formas mais rápidas de circulação, para tanto, a necessidade de modais que proporcionam velocidade de locomoção torna-se imprescindível para o sistema de circulação e mobilidade territorial. É nessa perspectiva que o estado representa o vetor principal no que tange a angariação de investimentos em infraestrutura aeroviária, como forma de promover o desenvolvimento urbano territorial e favorecer o crescimento do setor aéreo paulista.

  10. Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.

    Science.gov (United States)

    Kowenz-Leutz, Elisabeth; Schuetz, Anja; Liu, Qingbin; Knoblich, Maria; Heinemann, Udo; Leutz, Achim

    2016-07-01

    The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) regulates cell cycle arrest and terminal differentiation of neutrophils and adipocytes. Mutations in the basic leucine zipper domain (bZip) of C/EBPα are associated with acute myeloid leukemia. A widely used murine transforming C/EBPα basic region mutant (BRM2) entails two bZip point mutations (I294A/R297A). BRM2 has been discordantly described as defective for DNA binding or defective for interaction with E2F. We have separated the two BRM2 mutations to shed light on the intertwined reciprocity between C/EBPα-E2F-DNA interactions. Both, C/EBPα I294A and R297A retain transactivation capacity and interaction with E2F-DP. The C/EBPα R297A mutation destabilized DNA binding, whereas the C/EBPα I294A mutation enhanced binding to DNA. The C/EBPα R297A mutant, like BRM2, displayed enhanced interaction with E2F-DP but failed to repress E2F-dependent transactivation although both mutants were readily suppressed by E2F1 for transcription through C/EBP cis-regulatory sites. In contrast, the DNA binding enhanced C/EBPα I294A mutant displayed increased repression of E2F-DP mediated transactivation and resisted E2F-DP mediated repression. Thus, the efficient repression of E2F dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBPα.

  11. POLÍTICA NACIONAL DE DESENVOLVIMENTO REGIONAL E REPERCUSSÕES NO RIO GRANDE DO SUL

    Directory of Open Access Journals (Sweden)

    Antonio Paulo Cargnin

    2014-01-01

    Full Text Available Después de una década de vigencia, la Política Nacional de Desarrollo Regional (Política Nacional de Desenvolvimento Regional – PNDR se encuentra en proceso de revisión con el fin de ponerla en una posición de mayor importancia. El presente artículo pretende evaluar las repercusiones territoriales de la PNDR n el estado de Rio Grande do Sul y señalar elementos para la continuidad. En primer lugar, se realizó una análisis de los programas con una mayor incidencia en el territorio: el Programa de Promoción de Espacios Sostenibilidad Subregionales (Programa de Promoção da Sustentabilidade de Espaços Sub-Regionais – PROMESO y el Programa para el Desarrollo de la Franja Fronteriza (Programa de Desenvolvimento da Faixa de Fronteira – PDFF. A continuación, se evaluaron los resultados ya alcanzados por estos programas y se identificaron posibles repercusiones en el territorio. El artículo termina con algunas consideraciones sobre los resultados y el futuro de la PNDR.

  12. Prerrogativas estatais, integração regional e lógica distributiva State prerrogatives, regional integration, and distributive logic

    Directory of Open Access Journals (Sweden)

    Marcelo de A. Medeiros

    2003-01-01

    Full Text Available Analisa-se a emergência de um novo paradigma de ordem internacional, baseado em processos de integração regional no lugar do decadente Estado nacional, tendo em vista os limites a ele impostos pela persistência da dinâmica do Estado nacional. Assinala-se a dificuldade para substituir a lógica intergovernamental pela lógica supranacional. A ausência de organizações supranacionais efetivas impõe restrições à distribuição dos ganhos obtidos pela dinâmica integracionista. Examina-se isso com base nos casos do Mercosul e da União Européia.The emergency of a new paradigm of international order, based on processes of regional integration instead of the decadent national State is examined in view of the limits imposed on it by the persistence of the dynamics of the national State. The difficulty in substituting a supranational logic for the intergovernmental one is pointed out. The absence of effective supranational organizations imposes restrictions on the distribution of the gains attained through the integrationist dynamics. This is examined on the basis of the cases of the Mercosul and of the European Union.

  13. A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease.

    Directory of Open Access Journals (Sweden)

    Suganya Selvarajah

    Full Text Available The mosquito-borne alphavirus, chikungunya virus (CHIKV, has recently reemerged, producing the largest epidemic ever recorded for this virus, with up to 6.5 million cases of acute and chronic rheumatic disease. There are currently no licensed vaccines for CHIKV and current anti-inflammatory drug treatment is often inadequate. Here we describe the isolation and characterization of two human monoclonal antibodies, C9 and E8, from CHIKV infected and recovered individuals. C9 was determined to be a potent virus neutralizing antibody and a biosensor antibody binding study demonstrated it recognized residues on intact CHIKV VLPs. Shotgun mutagenesis alanine scanning of 98 percent of the residues in the E1 and E2 glycoproteins of CHIKV envelope showed that the epitope bound by C9 included amino-acid 162 in the acid-sensitive region (ASR of the CHIKV E2 glycoprotein. The ASR is critical for the rearrangement of CHIKV E2 during fusion and viral entry into host cells, and we predict that C9 prevents these events from occurring. When used prophylactically in a CHIKV mouse model, C9 completely protected against CHIKV viremia and arthritis. We also observed that when administered therapeutically at 8 or 18 hours post-CHIKV challenge, C9 gave 100% protection in a pathogenic mouse model. Given that targeting this novel neutralizing epitope in E2 can potently protect both in vitro and in vivo, it is likely to be an important region both for future antibody and vaccine-based interventions against CHIKV.

  14. Measurement of the transverse-longitudinal cross sections in the p(e-->,e'p)π0 reaction in the /Δ region

    Science.gov (United States)

    Mit-Bates Oops Collaboration; Kunz, C.; Kaloskamis, N. I.; Distler, M. O.; Zhou, Z.-L.; Alarcon, R.; Barkhuff, D.; Bernstein, A. M.; Bertozzi, W.; Calarco, J.; Casagrande, F.; Chen, J.; Comfort, J.; Dodson, G.; Dooley, A.; Dow, K.; Farkhondeh, M.; Georgakopoulos, S.; Gilad, S.; Hicks, R.; Hotta, A.; Jiang, X.; Karabarbounis, A.; Kowalski, S.; Margaziotis, D. J.; Mertz, C.; Miskimen, R.; Nakagawa, I.; Papanicolas, C. N.; Pavan, M. M.; Peterson, G.; Ramirez, A.; Rowntree, D.; Sarty, A. J.; Shaw, J.; Six, E.; Sparveris, N.; Soong, S.-B.; Stiliaris, S.; Tamae, T.; Tieger, D.; Tschalaer, C.; Tsentalovich, G.; Turchinetz, W.; Vellidis, C. E.; Warren, G. A.; Williamson, S.; Young, A.; Zhao, J.; Zwart, T.

    2003-07-01

    Accurate measurements of the p(e-->,e'p)π0 reaction were performed at Q2=0.127 (GeV/c)2 in the /Δ resonance energy region. The experiments at the MIT-Bates Linear Accelerator used an 820 MeV polarized electron beam with the out-of-plane magnetic spectrometer system (OOPS). In this Letter we report the first simultaneous determination of both the TL and /TL' (``fifth'' or polarized) cross sections at low Q2 where the pion cloud contribution is predicted to dominate the quadrupole amplitudes (E2 and C2). These are the real and imaginary parts of the transverse-longitudinal interference amplitudes and provide a sensitive determination of the Coulomb quadrupole amplitude and a test of reaction calculations. Comparisons with model calculations are presented. The empirical MAID calculation gives the best overall agreement with this accurate data. The parameters of this model for the values of the resonant multipoles are M1+(I=3/2)=(40.9+/-0.3)×10-3/mπ, /CMR=C2/M1=-6.5+/-0.3%, /EMR=E2/M1=-2.2+/-0.9%, where the errors are due to the experimental uncertainties.

  15. Regionalização e novos rumos para o SUS: a experiência de um colegiado regional Regionalization and new courses to SUS: the experience of a regional college

    Directory of Open Access Journals (Sweden)

    Emerson Assis

    2009-03-01

    Full Text Available Em que pese todos os avanços no Sistema Único de Saúde (SUS desde a sua implantação, são também notórias as suas fragilidades e seus limites. Um deles, não obstante a diretriz constitucional de regionalização, é que até recentemente não havia uma política concreta de estímulo de integração entre os municípios e, consequentemente, de regiões de saúde, tão necessárias à garantia da integralidade da atenção. Nos últimos três anos, entretanto, o Ministério da Saúde, com a implementação do Pacto pela Saúde, na sua dimensão da gestão, iniciou esse processo, que tem se mostrado promissor para o desenvolvimento e crescimento do SUS nacional. Este trabalho apresenta a experiência positiva de implantação de um Colegiado Regional no Estado de São Paulo, na região de Campinas, através da qual gestores e técnicos das secretarias de saúde estão se tornando sujeitos mais "empoderados" da construção da Saúde na região.Despite all the advances that have occurred in Sistema Único de Saúde (SUS - National Health System since its implementation, its weaknesses and limits are also remarkable. One of them, in spite of the constitutional guideline for regionalization, is that, until recently, there had been no concrete policy to stimulate integration between municipalities and, consequently, between health regions, which are necessary to ensure integral care. In the last three years, however, the Ministry of Health, with the implementation of the Health Pact in its management dimension, started this process, which has been promising to the development and growth of the national SUS. This study presents the positive experience of implementation of a Regional College in the State of São Paulo, in the region of Campinas, through which managers and technicians of the health departments are becoming empowered subjects of the construction of Health in the region.

  16. El comercio intra e inter-regional del sector Turismo en España

    OpenAIRE

    Llano Verduras, Carlos; Mata López, Tamara de la

    2009-01-01

    España es uno de los países líderes en el mundo en el sector del turismo. Este liderazgo ha fomentado la realización de estudios sobre el turismo de no residentes. Sin embargo, el número de estudios centrados en el comercio interior del sector es más limitado. En este artículo proponemos una metodología para estimar el comercio intra e interregional español del sector Turismo, combinando la información disponible en la Balanza de Pagos, la Encuesta Anual de Servicios del INE y ...

  17. First measurement of target and double spin asymmetries for polarized e- polarized p --> e p pi0 in the nucleon resonance region above the Delta(1232)

    CERN Document Server

    Biselli, A S; Amaryan, M J; Asryan, G; Avakian, H; Bagdasaryan, H; Baillie, N; Ball, J P; Baltzell, N A; Battaglieri, M; Bedlinskiy, I; Bellis, M; Benmouna, N; Berman, B L; Blaszczyk, L; Bookwalter, C; Boiarinov, S; Bosted, P; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Bültmann, S; Butuceanu, C; Calarco, J R; Careccia, S L; Carman, D S; Casey, L; Chen, S; Cheng, L; Cole, P L; Collins, P; Coltharp, P; Crabb, D; Credé, V; Dale, D; Dashyan, N; De Masi, R; De Vita, R; De Sanctis, E; Degtyarenko, P V; Deur, A; Dhamija, S; Dickson, R; Djalali, C; Dodge, G E; Doughty, D; Dugger, M; Dzyubak, O P; Egiyan, H; El Fassi, L; Elouadrhiri, L; Eugenio, P; Fedotov, G; Feuerbach, R; Fersch, R; Forest, T A; Fradi, A; Garçon, M; Gavalian, G; Gevorgyan, N; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Goetz, J T; Gohn, W; Gothe, R W; Graham, L; Griffioen, K A; Guidal, M; Guler, N; Guo, L; Gyurjyan, V; Hafidi, K; Hakobyan, H; Hanretty, C; Hassall, N; Hicks, K; Hleiqawi, I; Holtrop, M; Hyde-Wright, C E; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Ito, M M; Jenkins, D; Jo, H S; Johnstone, J R; Joo, K; Jüngst, H G; Kalantarians, N; Keller, D; Kellie, J D; Khandaker, M; Kim, W; Klein, A; Klein, F J; Kossov, M; Krahn, Z; Kubarovski, V; Kühn, J; Kuhn, S E; Kuleshov, S V; Kuznetsov, V; Lachniet, J; Laget, J M; Langheinrich, J; Lawrence, D; Livingston, K; Lu, H Y; MacCormick, M; Markov, N; Mattione, P; McKinnon, B; McNabb, J W C; Mecking, B A; Mestayer, M D; Meyer, C A; Mibe, T; Mikhailov, K; Mirazita, M; Mokeev, V; Moreno, B; Moriya, K; Morrow, S A; Moteabbed, M; Munevar, E; Mutchler, G S; Nadel-Turonski, P; Nasseripour, R; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Niroula, M R; Niyazov, R A; Nozar, M; Osipenko, M; Ostrovidov, A I; Park, K; Park, S; Pasyuk, E; Paterson, C; Anefalos Pereira, S; Pierce, J; Pivnyuk, N; Pogorelko, O; Pozdniakov, S; Price, J W; Prok, Y; Protopopescu, D; Raue, B A; Ricco, G; Ripani, M; Ritchie, B G; Rosner, G; Rossi, P; Sabati, F; Saini, M S; Salamanca, J; Salgado, C; Santoro, J P; Sapunenko, V; Schott, D; Schumacher, R A; Serov, V S; Sharabyan, Yu G; Sharov, D; Shvedunov, N V; Smith, E S; Sober, D I; Sokhan, D; Stavinsky, A; Stepanyan, S S; Stepanyan, S; Stokes, B E; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Tedeschi, D J; Tkabladze, A; Tkachenko, S; Todor, L; Ungaro, M; Vineyard, M F; Vlassov, A V; Watts, D P; Weinstein, L B; Weygand, D P; Williams, M; Wolin, E; Wood, M H; Yegneswaran, A; Yurov, M; Zana, L; Zhang, J; Zhao, B; Zhao, Z W

    2008-01-01

    The exclusive channel polarized proton(polarized e,e prime p)pi0 was studied in the first and second nucleon resonance regions in the Q2 range from 0.187 to 0.770 GeV2 at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). Longitudinal target and beam-target asymmetries were extracted over a large range of center-of-mass angles of the pi0 and compared to the unitary isobar model MAID, the dynamic model by Sato and Lee, and the dynamic model DMT. A strong sensitivity to individual models was observed, in particular for the target asymmetry and in the higher invariant mass region. This data set, once included in the global fits of the above models, is expected to place strong constraints on the electrocoupling amplitudes A_{1/2} and S_{1/2} for the Roper resonance N(1400)P11, and the N(1535)S11 and N(1520)D13 states.

  18. First measurement of target and double spin asymmetries for polarized e- polarized p --> e p pi0 in the nucleon resonance region above the Delta(1232)

    Energy Technology Data Exchange (ETDEWEB)

    Biselli, Angela; Burkert, Volker; Amaryan, Moscov; Amaryan, Moskov; Asryan, Gegham; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, J.P.; Ball, Jacques; Baltzell, Nathan; Battaglieri, Marco; Bedlinskiy, Ivan; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Blaszczyk, Lukasz; Bookwalter, Craig; Boyarinov, Sergey; Bosted, Peter; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Bultmann, S.; Bueltmann, Stephen; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Carman, Daniel; Casey, Liam; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Crabb, Donald; Crede, Volker; Dale, Daniel; Dashyan, Natalya; De Masi, Rita; De Vita, Raffaella; De Sanctis, Enzo; Degtiarenko, Pavel; Deur, Alexandre; Dhamija, Seema; Dickson, Richard; Djalali, Chaden; Dodge, Gail; Doughty, David; Dugger, Michael; Dzyubak, Oleksandr; Egiyan, Hovanes; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fedotov, Gleb; Feuerbach, Robert; Fersch, Robert; Forest, Tony; Fradi, Ahmed; Garcon, Michel; Gavalian, Gagik; Gevorgyan, Nerses; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gohn, Wesley; Gothe, Ralf; Graham, Lewis; Griffioen, Keith; Guidal, Michel; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Hassall, Neil; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Keller, Dustin; Kellie, James; Khandaker, Mahbubul; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Kossov, Mikhail; Krahn, Zebulun; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Kuznetsov, Viacheslav; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Livingston, Kenneth; Lu, Haiyun; MacCormick, Marion; Markov, Nikolai; Mattione, Paul; McKinnon, Bryan; McNabb, John; Mecking, Bernhard; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Mikhaylov, Konstantin; Mirazita, Marco; Mokeev, Viktor; Moreno, Brahim; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Nasseripour, Rakhsha; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kil; Park, Seungkyung; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Pierce, Joshua; Pivnyuk, Nikolay; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Prok, Yelena; Protopopescu, Dan; Raue, Brian; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Saini, Mukesh; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Schott, Diane; Schumacher, Reinhard; Serov, Vladimir; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Smith, Elton; Sober, Daniel; Sokhan, Daria; Stavinskiy, Aleksey; Stepanyan, Samuel; Stepanyan, Stepan; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tedeschi, David; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Todor, Luminita; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Watts, Daniel; Weinstein, Lawrence; Weygand, Dennis; Williams, M.; Wolin, Elliott; Wood, Michael; Yegneswaran, Amrit; Yurov, Mikhail; Zana, Lorenzo; Zhang, Jixie; Zhao, Bo; Zhao, Zhiwen

    2008-10-01

    DOI: http://dx.doi.org/10.1103/PhysRevC.78.045204
    The exclusive channel polarized proton(polarized e,e prime p)pi0 was studied in the first and second nucleon resonance regions in the Q2 range from 0.187 to 0.770 GeV2 at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). Longitudinal target and beam-target asymmetries were extracted over a large range of center-of-mass angles of the pi0 and compared to the unitary isobar model MAID, the dynamic model by Sato and Lee, and the dynamic model DMT. A strong sensitivity to individual models was observed, in particular for the target asymmetry and in the higher invariant mass region. This data set, once included in the global fits of the above models, is expected to place strong constraints on the electrocoupling amplitudes A_{1/2} and S_{1/2} for the Roper resonance N(1400)P11, and the N(1535)S11 and N(1520)D13 states.

  19. Penetration of ELF Currents and Electromagnetic Fields into the Off-Equatorial E-Region of the Earth's Ionosphere

    CERN Document Server

    Jain, Neeraj; Sharma, A S; Papadopoulos, K

    2012-01-01

    The generation of ELF (of the order of 10 Hz) currents and electromagnetic fields in the off-equatorial E-region (90-120 km) of the Earth's ionosphere and their subsequent penetration into the deeper ionospheric layers is studied theoretically and numerically. These ELF currents and fields are generated by the interaction of an electromagnetic pulse with the E-region at its lower boundary located at 90 km above the Earth's surface. The wave penetration (with a typical wavelength of the order of 10 km) of the generated ELF currents and fields into the deeper ionospheric layers up to 120 km takes place due to the dominance of the Hall conductivity over the Pederson conductivity in the region between 90-120 km and penetration becomes diffusive above 120 km. During night time, the increase in the wave speed due to the reduced conductivities leads to the deeper penetration. As the angle between Earth's magnetic field and horizontal is increased (going away from the equator), the currents and fields penetrate deepe...

  20. Plasma Vitamin E and Blood Selenium Concentrations in Norwegian Dairy Cows: Regional Differences and Relations to Feeding and Health

    Directory of Open Access Journals (Sweden)

    Sivertsen T

    2006-12-01

    Full Text Available Plasma α-tocopherol (vit E and blood selenium (Se concentrations in February were determined in samples from 314 dairy cows in Norway, selected to provide a representative subset of the Norwegian dairy cow population. Each sample was followed by a questionnaire with information about feeding of the cow at the time of sampling. The results were correlated to herd data and to calving and health data for each cow from the Norwegian Dairy Herd Recording System and the Norwegian Cattle Health Recording System. The mean concentrations were 6.9 μg vit E per ml plasma and 0.16 μg Se per g blood. Both levels were highest in mid lactation. Plasma vit E varied with the amount of silage fed to the cow, while blood Se varied with the amount of concentrates and mineral supplements, and with geographical region. No differences in vit E or Se levels were found between cows with recorded treatments for mastitis, parturient paresis or reproductive disorders in the lactation during or immediately prior to sampling, and those without such treatments. For ketosis, a small difference in blood Se was found between the groups with or without recorded treatments. It is concluded that winter-fed lactating cows in Norway had an adequate plasma level of vit E and a marginal-to-adequate level of Se.

  1. Plasma Vitamin E and Blood Selenium Concentrations in Norwegian Dairy Cows: Regional Differences and Relations to Feeding and Health

    Directory of Open Access Journals (Sweden)

    Østerås O

    2005-12-01

    Full Text Available Plasma α-tocopherol (vit E and blood selenium (Se concentrations in February were determined in samples from 314 dairy cows in Norway, selected to provide a representative subset of the Norwegian dairy cow population. Each sample was followed by a questionnaire with information about feeding of the cow at the time of sampling. The results were correlated to herd data and to calving and health data for each cow from the Norwegian Dairy Herd Recording System and the Norwegian Cattle Health Recording System. The mean concentrations were 6.9 μg vit E per ml plasma and 0.16 μg Se per g blood. Both levels were highest in mid lactation. Plasma vit E varied with the amount of silage fed to the cow, while blood Se varied with the amount of concentrates and mineral supplements, and with geographical region. No differences in vit E or Se levels were found between cows with recorded treatments for mastitis, parturient paresis or reproductive disorders in the lactation during or immediately prior to sampling, and those without such treatments. For ketosis, a small difference in blood Se was found between the groups with or without recorded treatments. It is concluded that winter-fed lactating cows in Norway had an adequate plasma level of vit E and a marginal-to-adequate level of Se.

  2. Possible evidence for partial demagnetization of electrons in the auroral E-region plasma during electron gas heating

    Directory of Open Access Journals (Sweden)

    C. Haldoupis

    Full Text Available A previous study, based on incoherent and coherent radar measurements, suggested that during auroral E-region electron heating conditions, the electron flow in the auroral electrojet undergoes a systematic counterclockwise rotation of several degrees relative to the E×B direction. The observational evidence is re-examined here in the light of theoretical predictions concerning E-region electron demagnetization caused by enhanced anomalous cross-field diffusion during strongly-driven Farley-Buneman instability. It is shown that the observations are in good agreement with this theory. This apparently endorses the concept of wave-induced diffusion and anomalous electron collision frequency, and consequently electron demagnetization, under circumstances of strong heating of the electron gas in the auroral electrojet plasma. We recognize, however, that the evidence for electron demagnetization presented in this report cannot be regarded as definitive because it is based on a limited set of data. More experimental research in this direction is thus needed.

  3. HENA CLOTHING FROM S K O P J E REGION O F MACEDONIA

    Directory of Open Access Journals (Sweden)

    Melek TUFAN

    2015-08-01

    Full Text Available Anatolian society provided cultural interaction greatly from Asia to Anatolia, from Anatolian to Europa and Africa with the historical improvment and the basic great culture provided by that history. Turkish people sent to Macedonia from interior parts of Anatolia for the r purpose of adopting there, carried their own culture, constructed close relation ship with local people and they enabled to comeinto variety of practice especially with the interaction of Turksh culture and their own culture. After the cultural interaction, Turkish emigrants lernt the Macedonian traditional clothes and the techniques used for sewing and making clothes and they had the first examples of that way of wearing. The differances and specialities taking place in that fashion became the most special heritage of that society. The clothes worn in special events gave information about the people who had them. In the study the purpose was to examine some women clothing samples worn at henanights in Üsküp Region in terms of materials, color, cut, sewing and decorating and help carrying it tonext generations.

  4. Air quality assessment in Portugal and the special case of the Tâmega e Sousa region

    Science.gov (United States)

    de Almeida, Fátima; Correia, Aldina; Silva, Eliana Costa e.

    2017-06-01

    Air pollution is a major environmental problem which can present a significant risk for human health. This paper, presents the evaluation of the air quality in several region of Portugal. Special focus is given to the region of Tâmega e Sousa where ESTG/P. Porto is located. ANOVA and MANOVA techniques are applied to study the differences between air quality in the period between 2009 and 2012 in several regions of Portugal. The data includes altitude, area, expenditure of environmental measures on protection of air quality and climate, expenditure on protection of biodiversity and landscape, burned area, number of forest fires, extractive and manufacturing industries, per municipality and per year. Using information gathered by the project QualAr about concentrations of the pollutants: CO, NO2, O3, PM10 and SO2, an air quality indicator with five levels is consider. The results point to significant differences in the air quality for the regions and the years considered. Additionally, for identifying the factors that influence the air quality in 2012 a multivariate regression model was used. The results show statistical evidence that air quality in 2011, number of forest fires in 2012 and 2010, number of manufacturing industries per km2 in 2012 and number of forest fires in 2010 are the variables that present a larger contribution to the quality of the air in 2012.

  5. A floristic study of Kuh-e Khom in Tang Shekan region of Arsanjan county in Fars province

    Directory of Open Access Journals (Sweden)

    Masumeh Zare

    2015-10-01

    Full Text Available A floristic study was done in Kuh-e Khom in east of Arsanjan county as part of the southern Zagros in Fars province. Altitude of the region is ranged from 1740 to 3270 m above sea level. The flora of the region with an emphasis on identifying habitats and the effect of altitude on vegetation were studied and sampling was done from 2010 to 2012. Totally, 440 plant specimens of vascular plant were collected which were belonging to 50 families, 198 genera and 287 species. The angiosperm plants were dominant and from them the dicot plants with 37 families, 167 genera and 246 species had the most diversity. The monocots plants with 9 families, 27 genera and 37 species were the second diversely group in the region. Gymnosperms and Pteridophyte each with two species had the lowest number of species. In respect to species richness, Asteraceae (43 species was the largest family and after that Breassicaceae (33 species, Poaceae (24 species, Fabaceae (24 species, Lamiaceae (22 species, Caryophyllaceae (19 species and Boraginaceae (13 species had the most species diversity. Half of species were therophyte and 68% of species were belonging to Irano-Turanian region.

  6. An HTS flux pump operated by directly driving a superconductor into flux flow region in the E- J curve

    Science.gov (United States)

    Geng, Jianzhao; Coombs, T. A.

    2016-09-01

    High-T c superconducting (HTS) flux pumps are capable of compensating the persistent current decay in HTS magnets without electrical contact. In this paper, following work on a low-T c superconducting self-switching flux pump, we propose a new HTS flux pump by directly driving a high-T c superconductor into the flux flow region in the E- J curve. The flux pump consists of a transformer which has a superconducting secondary winding shorted by an YBCO-coated conductor bridge. A high alternating current with a much higher positive peak value than the negative peak value is induced in the secondary winding. The current always drives the bridge superconductor into the flux flow region only at around its positive peak value, thus resulting in flux pumping. The proposed flux pump is much simpler than existing HTS flux pumps.

  7. Turismo no Parque Nacional da Serra do Itajaí (SC) e suas implicações para o desenvolvimento regional sustentável

    OpenAIRE

    Noll, Gisele Odebrecht, 1988-; Reis, Clóvis, 1968-; Universidade Regional de Blumenau. Programa de Pós-Graduação em Desenvolvimento Regional.

    2016-01-01

    Orientador: Clóvis Reis. Dissertação (Mestrado em Desenvolvimento Regional) - Programa de Pós-Graduação em Desenvolvimento Regional, Centro de Ciências Humanas e da Comunicação, Universidade Regional de Blumenau, Blumenau,

  8. Entrepreneurial university and regional sustainable development: proposal of a model Universidade empreendedora e o desenvolvimento regional sustentável: proposta de um modelo

    Directory of Open Access Journals (Sweden)

    Frank Leonardo Casado

    2013-03-01

    Full Text Available Universities, are creators of knowledge, are potential actors of sustainable development practices and social responsibility. Even if it is evident the importance of effective actions that are being carried out within the framework of the universities, it is known that society expects much more than they've been doing. Highlights therefore following paradox: on the one hand, the universities, primarily the federal institutions of higher education (IFES, develop many social actions (extension, generate new technologies (search and form quality professionals (teaching. On the other hand, it is possible to say that a larger contribution is required to meet the demands of the population where are inserted, if making urgent greater participation in the process of sustainable development of their regions of comprehensiveness. The quest-to achieve these goals, it was the preparation of foundations for implementation of a program of innovative entrepreneurship. Which shows necessary for allowing the unification of isolated initiatives today, the search for financing of strategic projects, the definition and implementation of policy on entrepreneurship and innovation of institution and the consolidation of administrative structure capable of supporting the demands of teaching, research and extension.DOI: 10.5902/198346597755As universidades, como criadoras e disseminadoras de conhecimento, constituem-se em potenciais agentes de práticas de desenvolvimento sustentável e responsabilidade social. Mesmo que seja evidente a importância das ações efetivas que estão sendo realizadas no âmbito das universidades, sabe-se que a sociedade espera bem mais do que elas já vêm realizando. Evidencia-se, assim, o seguinte paradoxo: por um lado, as universidades, principalmente as Instituições Federais de Ensino (IFES, desenvolvem muitas ações sociais (extensão, geram novas tecnologias (pesquisa e formam profissionais de qualidade (ensino. Por outro lado,

  9. Vibronic interactions in NO 3: from the 2E' origin region to the NO + O 2 reactive channel

    Science.gov (United States)

    Valachovic, L.; Riehn, C.; Mikhaylichenko, K.; Wittig, C.

    1996-08-01

    LIF spectra of expansion-cooled NO 3 in the region 595-666 nm reveal vibronic interactions responsible for 2E' radiationless decay. A hierarchy of coupling strengths is suggested. Due the large atomic masses, tunneling results in small unimolecular decomposition rates below the NO + O 2 barrier on the 2A' 2 ground potential surface. These have been observed via their quenching of long-lived NO 3 fluorescence, and rates as small as 3 × 10 4 s -1 are reported. This is 5 orders of magnitude smaller than the rate just above the barrier, which had been determined previously by using the ultrafast pump-probe technique.

  10. Tetrabromobisphenol A and heavy metal exposure via dust ingestion in an e-waste recycling region in Southeast China.

    Science.gov (United States)

    Wu, Yuanyuan; Li, Yanyan; Kang, Duan; Wang, Jingjing; Zhang, Yanfang; Du, Dongli; Pan, Bishu; Lin, Zhenkun; Huang, Changjiang; Dong, Qiaoxiang

    2016-01-15

    This study was designed to investigate a prevalent brominated flame retardant tetrabromobisphenol A (TBBPA) and four heavy metals of Pb, Cr, As, Cd in dust samples (52 indoor and 52 outdoor) collected from residential houses in an e-waste recycling area in Southeast China. For TBBPA, the mean concentration in indoor dust (3435 ng/g, dw) was higher than that in outdoor dust (1998 ng/g, dw). For heavy metals, the mean concentrations of Pb, Cr, As, Cd were 399, 151, 48.13, and 5.85 mg/kg in indoor dust, respectively, and were 328, 191, 17.59, and 4.07 mg/kg in outdoor dust, respectively. Except for As, concentrations of TBBPA and other metals decreased with the increased distance away from the e-waste recycling center, suggesting significant contribution of e-waste activities. The daily exposure doses of TBBPA ranged from 0.04 to 7.50 ng/kg-bw/day for adults and from 0.31 to 58.54 ng/kg-bw/day for children, representing the highest values reported to date for TBBPA exposure via dust ingestion. Daily exposure doses of Cr, As, and Cd were all below the reference doses. However, daily exposure dose of Pb for children in areas near the e-waste processing center was above the reference dose, posing significant health concern for children in that region.

  11. AMERICA LATINA: UNA REGION EN RIESGO. POBREZA, INEQUIDAD E INSTITUCIONALIDAD SOCIAL

    Directory of Open Access Journals (Sweden)

    Bernardo Kliksberg

    2011-08-01

    Full Text Available El tema social se halla actualmente en el centro del escenario histórico de América Latina. Se suceden desde las más variadas fuentes los llamados de alerta sobre la magnitud y profundidad de los problemas que sacuden a la región en el campo social. La mayor reunión de Presidentes del Continente, la cumbre hemisférica (Santiago de Chile, 1998 consignó en su declaración final, suscrita por todos los mandatarios, que “superar la pobreza continúa siendo el mayor desafío confrontado por nuestro Hemisferio”. Caracterizando algunos de los principales problemas existentes, los Presidentes indicaron “estamos decididos a remover las barreras que deniegan a los pobres el acceso a nutrición adecuada, servicios sociales, un medio ambiente saludable, créditos y títulos legales sobre su propiedad”. El Secretario General de la CEPAL, José A. Ocampo resaltó (1998 sobre la situación que “siguen aumentando los niveles de pobreza absoluta, los niveles de desigualdad no muestran mejoría y sigue aumentando el empleo en el sector informal”. El Presidente del BID, Enrique V. Iglesias ha destacado (1997 que “el proceso de cambio ha dejado sin resolver en la gran mayoría de los países un tema central: la pobreza crítica y la mala distribución del ingreso”. El Banco Mundial ha hecho continuos señalamientos sobre la gravedad del problema: “América Latina es notable como una región en la que la pobreza, particularmente la pobreza absoluta, no registra mejora alguna” (Burki, 1996, e indicó en reciente conferencia internacional sobre la región (Chile, 1999, los riesgos que corría la democracia en tales condiciones.

  12. Sequence analysis of the E3 region and fiber gene of human adenovirus genome type 7h.

    Science.gov (United States)

    Kajon, A E; Wadell, G

    1996-01-15

    Adenovirus type 7h is currently the predominant virulent genome type of serotype 7 isolated in Argentina, Chile, and Uruguay in association with severe infantile pneumonia. In order to characterize possible molecular determinants of pathogenicity, the nucleotide sequence of a 5904-bp fragment (76 to 93 mu) containing the entire E3 region and the fiber gene of Ad7h was established. The organization of the ORFs within the E3 region was similar to that reported for the prototype strains of Ad7 and Ad3. A comparison of the nucleotide and amino acid sequences of all ORFs revealed a higher homology between Ad7h and Ad7p than between Ad7h and Ad3 for 12.0K and 16.1K, whereas the 15.3K ORF and the adjacent fiber gene were strikingly more homologous to those of Ad3 (99.5 vs 81.1% and 98.2 vs 66.6%, respectively). The equivalent to ORF 7.7K in Ad7p was missing in Ad7h due to a deletion and a mutation affecting the start codon (ATG-->ATT). Although the hemagglutinin of the Ad7h fiber could not be characterized due to its lack of activity on monkey erythrocytes, our results indicate that Ad7h is an intermediate strain 7-3.

  13. Aspect sensitive E- and F-region SPEAR-enhanced incoherent backscatter observed by the EISCAT Svalbard radar

    Directory of Open Access Journals (Sweden)

    R. S. Dhillon

    2009-01-01

    Full Text Available Previous studies of the aspect sensitivity of heater-enhanced incoherent radar backscatter in the high-latitude ionosphere have demonstrated the directional dependence of incoherent scatter signatures corresponding to artificially excited electrostatic waves, together with consistent field-aligned signatures that may be related to the presence of artificial field-aligned irregularities. These earlier high-latitude results have provided motivation for repeating the investigation in the different geophysical conditions that obtain in the polar cap ionosphere. The Space Plasma Exploration by Active Radar (SPEAR facility is located within the polar cap and has provided observations of RF-enhanced ion and plasma line spectra recorded by the EISCAT Svalbard UHF incoherent scatter radar system (ESR, which is collocated with SPEAR. In this paper, we present observations of aspect sensitive E- and F-region SPEAR-induced ion and plasma line enhancements that indicate excitation of both the purely growing mode and the parametric decay instability, together with sporadic E-layer results that may indicate the presence of cavitons. We note consistent enhancements from field-aligned, vertical and also from 5° south of field-aligned. We attribute the prevalence of vertical scatter to the importance of the Spitze region, and of that from field-aligned to possible wave/irregularity coupling.

  14. Forward hard scattering in hadron-hadron collisions in the energy region approximately 10/sup 14/ eV

    CERN Document Server

    Shibata, T

    1980-01-01

    On the basis of the quark-parton picture, the author derives analytically the cross sections for production of hadrons and gamma rays through forward hard scattering in hadron-hadron collisions in the energy region approximately 10/sup 14/ eV. The author takes account of transverse motions both of partons inside proton (p/sub T/) /sub p to q/, and of hadrons fragmented from quark (gluon) (k/sub T/) /sub 1 to h/. In addition, the effects of scale violation are taken into account. The numerical results thus obtained are compared with cosmic-ray data in the energy region approximately 10/sup 14/ eV, observed at Mt. Chacaltaya by Japan-Brazil emulsion-chamber collaboration. After eliminating carefully the bias effect inherent there, it was found that the theoretical calculations reproduced surprisingly well the cosmic-ray data on large p/sub T gamma / not only in the shape, but also in the absolute value. The production cross sections of pi /sup +/ and K/sup +/ expected from the forthcoming p-p colliding beams wi...

  15. Competition between winds and electric fields in the formation of blanketing sporadic E layers at equatorial regions

    Science.gov (United States)

    Resende, Laysa Cristina Araújo; Batista, Inez Staciarini; Denardini, Clezio Marcos; Carrasco, Alexander José; de Fátima Andrioli, Vânia; Moro, Juliano; Batista, Paulo Prado; Chen, Sony Su

    2016-12-01

    In the present work, we analyze the competition between tidal winds and electric fields in the formation of blanketing sporadic E layers (Esb) over São Luís, Brazil (2° 31' S, 44° 16' W), a quasi-equatorial station. To investigate this competition, we have used an ionospheric E region model (MIRE) that is able to model the Esb layers taking into account the E region winds and electric fields. The model calculates the densities for the main molecular and metallic ions by solving the continuity and momentum equations for each of the species. Thus, the main purpose of this analysis is to verify the electric fields role in the occurrence or disruption of Esb layers through simulations. The first results of the simulations show that the Esb layer is usually present when only the tidal winds were considered. In addition, when the zonal component of the electric field is introduced in the simulation, the Esb layers do not show significant changes. However, the simulations show the disruption of the Esb layers when the vertical electric field is included. In this study, we present two specific cases in which Esb layers appear during some hours over São Luís. We can see that these layers appear when the vertical electric field was weak, which means that the tidal components were more effective during these hours. Therefore, the vertical component of the electric field is the main agent responsible for the Esb layer disruption. [Figure not available: see fulltext. Caption: Ionograms from São Luís on January 5, 2005, show a clear case of the competition between electric fields and wind effects in the Es layer formation. In ionograms, the Esq trace is clearly seen and identified by a blue arrow. Besides the Esq, we can identify another Es trace at 1415 UT (identified by a black arrow) that persists until 1600 UT. This layer becomes stronger in each ionogram, as can be seen by its effect on partially blocking the reflection from the low-frequency end of F region above

  16. Molecular identification of cetaceans from the West Atlantic using the E3-I5 region of COI.

    Science.gov (United States)

    Falcão, L H O; Campos, A S; Freitas, J E P; Furtado-Neto, M A A; Faria, V V

    2017-04-20

    Molecular identification is very useful in cases where morphology-based species identification is not possible. Examples for its application in cetaceans include the identification of carcasses of stranded animals in advanced state of decomposition and body parts that are illegally traded. One DNA region that is often used for molecular identification is the Folmer region of the mitochondrial gene cytochrome c oxidase subunit I (COI) (locus 48 to 705 bp). This locus has been used for the identification of several animal species, including whales and dolphins. The goal of the present study was to evaluate the usefulness of another region of COI, the E3-I5 (locus 685 to locus 1179; 495 bp) as a marker for identification of cetaceans from northeastern Canada and northeastern Brazil. The identification markers were successfully obtained for seven cetacean species after performing percent identity and Basic Local Alignment Search Tool analyses. The obtained markers are now publicly available and are useful for the identification of the endangered blue whale (Balaenoptera musculus), common minke whale (B. acutorostrata), vulnerable sperm whale (Physeter macrocephalus), harbor porpoise (Phocoena phocoena), common bottlenose dolphin (Tursiops truncatus), Guiana dolphin (Sotalia guianensis), and melon-headed whale (Peponocephala electra).

  17. Occurrence of Sporadic -E layer during the Low Solar Activity over the Anomaly Crest Region Bhopal, India

    Science.gov (United States)

    Bhawre, Purushottam

    2016-07-01

    Ionospheric anomaly crest regions are most challenging for scientific community to understand its mechanism and investigation, for this purpose we are investigating some inospheric result for this region. The study is based on the ionogram data recorded by IPS-71 Digital Ionosonde installed over anomaly crust region Bhopal (Geo.Lat.23.2° N, Geo. Long77.4° E, Dip latitude18.4°) over a four year period from January 2007 to December 2010, covering the ending phase of 23rd Solar Cycle and starting phase of 24th solar cycle. This particular period is felt to be very suitable for examining the sunspot number and it encompasses periods of low solar activities. Quarterly ionograms are analyzed for 24 hours during these study years and have been carefully examined to note down the presence of sporadic- E. We also note down the space weather activities along with the study. The studies are divided in mainly four parts with space and geomagnetic activities during these periods. The occurrence probability of this layer is highest in summer solstice, moderate during equinox and low during winter solstice. Remarkable occurrence peaks appear from June to July in summer and from December to January in winter. The layer occurrence showed a double peak variation with distinct layer groups, in the morning (0200 LT) and the other during evening (1800 LT).The morning layer descent was associated with layer density increase indicating the strengthening of the layer while it decreased during the evening layer descent. The result indicates the presence of semi-diurnal tide over the location while the higher descent velocities could be due to the modulation of the ionization by gravity waves along with the tides. The irregularities associated with the gradient-drift instability disappear during the counter electrojet and the current flow is reversed in westward.

  18. Measurement of the Polarized Structure Function $\\sigma_{LT^\\prime}$ for $p(\\vec{e},e'\\pi^+)n$ in the $\\Delta(1232)$ Resonance Region

    CERN Document Server

    Joo, K; Aznauryan, I G; Burkert, V D; Minehart, R C; Adams, G; Ambrozewicz, P; Anciant, E; Anghinolfi, M; Asavapibhop, B; Asryan, G; Audit, G; Auger, T; Avakian, H; Bagdasaryan, H; Ball, J P; Barrow, S; Batourine, V; Battaglieri, M; Beard, K; Bektasoglu, M; Benmouna, N; Bianchi, N; Biselli, A S; Boiarinov, S; Bonner, B E; Bouchigny, S; Bradford, R; Branford, D; Briscoe, W J; Brooks, W K; Bültmann, S; Butuceanu, C; Calarco, J R; Carman, D S; Carnahan, B; Cetina, C; Chen, S; Ciciani, L; Cole, P L; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J P; De Sanctis, E; De Vita, R; Degtyarenko, P V; Dennis, L; Deur, A; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Doughty, D; Dragovitsch, P; Dugger, M; Dytman, S; Dzyubak, O P; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Empl, A; Eugenio, P; Fersch, R; Feuerbach, R J; Forest, T A; Funsten, H; Gaff, S J; Garçon, M; Gavalian, G; Gilad, S; Gilfoyle, G P; Giovanetti, K L; Gothe, R W; Griffioen, K A; Guidal, M; Guillo, M R; Guler, N; Guo, L; Gyurjyan, V; Hadjidakis, C; Hakobyan, R S; Hardie, J; Heddle, D; Hersman, F W; Hicks, K; Hleiqawi, I; Holtrop, M; Hu, J; Hyde-Wright, C E; Ilieva, Y; Ireland, D; Ito, M M; Jenkins, D; Jüngst, H G; Kellie, J D; Kelley, J H; Khandaker, M; Kim, K Y; Kim, K; Kim, W; Klein, A; Klein, F J; Klimenko, A V; Klusman, M; Kossov, M; Koubarovski, V; Kramer, L H; Kuhn, S E; Kühn, J; Lachniet, J; Laget, J M; Langheinrich, J; Lawrence, D; Lee, T; Livingston, K; Lukashin, K; Manak, J J; Marchand, C; McAleer, S; McNabb, J W C; Mecking, B A; Mestayer, M D; Meyer, C A; Mikhailov, K; Mirazita, M; Miskimen, R; Mokeev, V; Morand, L; Morrow, S A; Muccifora, V; Müller, J; Mutchler, G S; Napolitano, J; Nasseripour, R; Nelson, S O; Niccolai, S; Niculescu, G; Niculescu, I; Niczyporuk, B B; Niyazov, R A; Nozar, M; O'Rielly, G V; Osipenko, M; Ostrovidov, A I; Park, K; Pasyuk, E A; Peterson, G; Philips, S A; Pivnyuk, N; Pocanic, D; Pogorelko, O I; Polli, E; Pozdniakov, S; Preedom, B M; Price, J W; Prok, Y; Protopopescu, D; Qin, L M; Raue, B A; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Ronchetti, F; Rosner, G; Rossi, P; Rowntree, D; Rubin, P D; Sabatie, F; Sabourov, K; Salgado, C; Santoro, J P; Sapunenko, V; Schumacher, R A; Serov, V S; Sharabyan, Yu G; Shaw, J; Simionatto, S; Skabelin, A V; Smith, E S; Sober, D I; Spraker, M; Stavinsky, A V; Stepanyan, S; Stokes, B E; Stoler, P; Strakovsky, I I; Strauch, S; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Tkabladze, A; Todor, L; Tur, C; Ungaro, M; Vineyard, M F; Vlassov, A V; Wang, K; Weinstein, L B; Weller, H; Weygand, D P; Williams, M; Wolin, E; Wood, M H; Yegneswaran, A; Yun, J; Zana, L

    2004-01-01

    The polarized longitudinal-transverse structure function $\\sigma_{LT^\\prime}$ has been measured using the $p(\\vec e,e'\\pi^+)n$ reaction in the $\\Delta(1232)$ resonance region at $Q^2=0.40$ and 0.65 GeV$^2$. No previous $\\sigma_{LT^\\prime}$ data exist for this reaction channel. The kinematically complete experiment was performed at Jefferson Lab with the CEBAF Large Acceptance Spectrometer (CLAS) using longitudinally polarized electrons at an energy of 1.515 GeV. A partial wave analysis of the data shows generally better agreement with recent phenomenological models of pion electroproduction compared to the previously measured $\\pi^0 p$ channel. A fit to both $\\pi^0 p$ and $\\pi^+ n$ channels using a unitary isobar model suggests the unitarized Born terms provide a consistent description of the non-resonant background. The $t$-channel pion pole term is important in the $\\pi^0 p$ channel through a rescattering correction, which could be model-dependent.

  19. Polarized Structure Function $\\sigma_{LT'}$ for $p({\\vec e},e'K^+)\\Lambda$ in the Nucleon Resonance Region

    Energy Technology Data Exchange (ETDEWEB)

    Nasseripour, Rakhsha; Raue, Brian; Ambrozewicz, Pawel; Carman, Daniel; Amaryan, Moscov; Amaryan, Moskov; Anciant, Eric; Anghinolfi, Marco; Asavapibhop, Burin; Asryan, Gegham; Audit, Gerard; Auger, Thierry; Avagyan, Harutyun; Baghdasaryan, Hovhannes; Baillie, Nathan; Ball, J.P.; Ball, Jacques; Ball, J.P.; Ball, Jacques; Ball, J.P.; Ball, Jacques; Ball, J.P.; Ball, Jacques; Baltzell, Nathan; Barrow, Steve; Battaglieri, Marco; Beard, Kevin; Bedlinskiy, Ivan; Bektasoglu, Mehmet; Bellis, Matthew; Benmouna, Nawal; Berman, Barry; Biselli, Angela; Blaszczyk, Lukasz; Bonner, Billy; Bouchigny, Sylvain; Boyarinov, Sergey; Bradford, Robert; Branford, Derek; Briscoe, William; Brooks, William; Burkert, Volker; Butuceanu, Cornel; Calarco, John; Careccia, Sharon; Casey, Liam; Cetina, Catalina; Chen, Shifeng; Cheng, Lu; Cole, Philip; Collins, Patrick; Coltharp, Philip; Cords, Dieter; Corvisiero, Pietro; Crabb, Donald; Crede, Volker; Dale, Daniel; Dashyan, Natalya; De Masi, Rita; De Vita, Raffaella; De Sanctis, Enzo; Degtiarenko, Pavel; Dennis, Lawrence; Deur, Alexandre; Dhuga, Kalvir; Dickson, Richard; Djalali, Chaden; Dodge, Gail; Doughty, David; Dragovitsch, Peter; Dugger, Michael; Dytman, Steven; Dzyubak, Oleksandr; Egiyan, Hovanes; Egiyan, Kim; Elfassi, Lamiaa; Elouadrhiri, Latifa; Eugenio, Paul; Fatemi, Renee; Fedotov, Gleb; Feldman, Gerald; Feuerbach, Robert; Forest, Tony; Fradi, Ahmed; Funsten, Herbert; Garcon, Michel; Gavalian, Gagik; Gevorgyan, Nerses; Gilfoyle, Gerard; Giovanetti, Kevin; Girard, Pascal; Girod, Francois-Xavier; Goetz, John; Gothe, Ralf; Gothe, Ralf; Griffioen, Keith; Guidal, Michel; Guillo, Matthieu; Guler, Nevzat; Guo, Lei; Gyurjyan, Vardan; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Hardie, John; Heddle, David; Hersman, F.; Hicks, Kenneth; Hleiqawi, Ishaq; Holtrop, Maurik; Hu, Jicun; Hyde, Charles; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Ito, Mark; Jenkins, David; Jo, Hyon-Suk; Johnstone, John; Joo, Kyungseon; Juengst, Henry; Kalantarians, Narbe; Kellie, James; Khandaker, Mahbubul; Kim, Kui; Kim, Kyungmo; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Kossov, Mikhail; Krahn, Zebulun; Kramer, Laird; Kubarovsky, Valery; Kuhn, Joachim; Kuhn, Sebastian; Kuleshov, Sergey; Kuznetsov, Viacheslav; Lachniet, Jeff; Laget, Jean; Langheinrich, Jorn; Lawrence, David; Livingston, Kenneth; Lu, Haiyun; Lukashin, Konstantin; MacCormick, Marion; Manak, Joseph; Markov, Nikolai; Mattione, Paul; McAleer, Simeon; McKinnon, Bryan; McNabb, John; Mecking, Bernhard; Mestayer, Mac; Meyer, Curtis; Mibe, Tsutomu; Mikhaylov, Konstantin; Minehart, Ralph; Mirazita, Marco; Miskimen, Rory; Mokeev, Viktor; Moreno, Brahim; Moriya, Kei; Morrow, Steven; Moteabbed, Maryam; Mueller, James; Munevar Espitia, Edwin; Mutchler, Gordon; Nadel-Turonski, Pawel; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Niczyporuk, Bogdan; Niroula, Megh; Niyazov, Rustam; Nozar, Mina; Osipenko, Mikhail; Ostrovidov, Alexander; Park, Kijun; Pasyuk, Evgueni; Paterson, Craig; Pereira, Sergio; Peterson, Gerald; Philips, Sasha; Pierce, Joshua; Pivnyuk, Nikolay; Pocanic, Dinko; Pogorelko, Oleg; Pozdnyakov, Sergey; Preedom, Barry; Price, John; Procureur, Sebastien; Prok, Yelena; Protopopescu, Dan; Qin, Liming; Riccardi, Gregory; Ricco, Giovanni; Ripani, Marco; Ritchie, Barry; Rosner, Guenther; Rossi, Patrizia; Rubin, Philip; Sabatie, Franck; Salamanca, Julian; Salgado, Carlos; Santoro, Joseph; Sapunenko, Vladimir; Sayre, Donald; Schumacher, Reinhard; Serov, Vladimir; Shafi, Aziz; Sharabian, Youri; Sharov, Dmitri; Shvedunov, Nikolay; Simionatto, Sebastio; Skabelin, Alexander; Smith, Elton; Smith, Lee; Sober, Daniel; Sokhan, Daria; Stavinsky, Aleksey; Stepanyan, Samuel; Stepanyan, Stepan; Stokes, Burnham; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Taylor, Shawn; Tedeschi, David; Thoma, Ulrike; Thompson, Richard; Tkabladze, Avtandil; Tkachenko, Svyatoslav; Ungaro, Maurizio; Vineyard, Michael; Vlassov, Alexander; Wang,

    2008-06-01

    The first measurements of the polarized structure function $\\sigma_{LT'}$ for the reaction $p(\\vec e,e'K^+)\\Lambda$ in the nucleon resonance region are reported. Measurements are included from threshold up to $W$=2.05 GeV for central values of $Q^2$ of 0.65 and 1.00 GeV$^2$, and nearly the entire kaon center-of-mass angular range. $\\sigma_{LT'}$ is the imaginary part of the longitudinal-transverse response and is expected to be sensitive to interferences between competing intermediate s-channel resonances, as well as resonant and non-resonant processes. The results for $\\sigma_{LT'}$ are comparable in magnitude to previously reported results from CLAS for $\\sigma_{LT}$, the real part of the same response. An intriguing sign change in $\\sigma_{LT'}$ is observed in the high $Q^2$ data at $W\\approx 1.9$ GeV. Comparisons to several existing model predictions are shown.

  20. Comparação de lornoxicam e fentanil adicionados à lidocaína em anestesia regional intravenosa

    Directory of Open Access Journals (Sweden)

    Nezih Sertoz

    2013-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVO: Comparar os efeitos analgésicos nos períodos intra e pós-operatório de lornoxicam e fentanil adicionados à lidocaína para anestesia regional intravenosa (ARIV em um grupo de pacientes submetidos à cirurgia de mão. MÉTODOS: Estudo randômico, duplo-cego e controlado. Foram incluídos e randomizados 45 pacientes em três grupos: o Grupo I recebeu 3 mg.kg-1 de lidocaína a 2% (40 mL; o Grupo II recebeu 3 mg.kg-1 de lidocaína (38 mL + 2 mL de lornoxicam; o Grupo III recebeu 3 mg.kg-1 de lidocaína (38 mL + 2 mL de fentanil. O desfecho primário avaliado foi o tempo até a primeira necessidade de analgésicos no pós-operatório. RESULTADOS: Lornoxicam adicionado à lidocaína em ARIV aumentou o tempo de recuperação do bloqueio sensorial sem aumentar os efeitos colaterais, e o tempo até a primeira necessidade de analgésicos no pós-operatório em comparação com lidocaína sozinha (p 0,05, embora os escores da escala visual analógica (EVA relacionados à dor ocasionada pelo torniquete tenham sido menores no grupo fentanil. Lornoxicam adicionado à lidocaína em ARIV não foi superior à lidocaína sozinha para diminuir a dor ocasionada pelo torniquete. CONCLUSÃO: A adição de fentanil à lidocaína em ARIV parece ser superior à lidocaína sozinha e ao lornoxicam adicionado à lidocaína para diminuir a dor ocasionada pelo torniquete, apesar de aumentar os efeitos secundários. No entanto, lornoxicam não aumentou os efeitos secundários e proporcionou analgesia nos períodos tanto intraoperatório quanto pós-operatório. Portanto, lornoxicam pode ser mais adequado para o uso clínico.

  1. Spectroscopic research of Lambda hypernuclei up to medium-heavy mass region with the (e,e'K+) reaction

    Energy Technology Data Exchange (ETDEWEB)

    Gogami, Toshiyuki [Tohoku Univ., Sendai (Japan)

    2014-06-01

    In 2009 (August-November), the E05-115 experiment was carried out at JLab to investigate L hypernuclei in the wide mass region up to A = 52 ($7\\atop{Λ}$He, $10\\atop{Λ}$Be, $12\\atop{Λ}$B and $52\\atop{Λ}$V) with the (e,e'K+) reaction. This is the first attempt to investigate a medium heavy L hypernucleus with the (e,e'K+) reaction. Experimentally, it is difficult to measure heavier L hypernuclei as background rates of particles which originate from electromagnetic processes are roughly in proportion to Z2 (Z: target proton number) in the (e,e'K+) experiment. To perform the experiment, many experimental techniques have been developed and introduced such as optimization of the electron spectrometer configuration (tilt method), clean kaon identification, particle tracking under high multiplicity environment, precise energy scale calibration and so on. In the present thesis, experimental results of the elementary process of p(e,e'K+)L, L hypernuclei of $7\\atop{Λ}$He, $10\\atop{Λ}$Be, $12\\atop{Λ}$B and $52\\atop{Λ}$V are shown. Elementary processes of the electroproduction of L and Σ0, p(e,e'K+)L, Σ0 were used for the absolute energy scale calibration of our spectrometer systems. A careful Monte Carlo simulation shows that the binding energy can be obtained with a systematic error of 0.11 MeV with our energy scale calibration method. A study of the elementary process of L is important to understand L hypernuclei as it is essential for theoretical calculations of L hypernuclei. The differential cross section of the p(e,e'K+)L reaction at the small K+ scattering angle (theta-CM/gamma-K approx. 15.5°), the small Q2 (approx 0.01 [GeV/c]2) and the total energy of W = 1.92 GeV, where no experimental data exists was obtained to be 235 ± 13$+28\\atop{-24}$ nb/sr. The ground state (1/2+) binding energy

  2. H.E.S.S. observations of the Galactic Center region and their possible dark matter interpretation

    CERN Document Server

    Aharonian, F A; Bazer-Bachi, A R; Beilicke, M; Benbow, W; Berge, D; Bernlöhr, K; Boisson, C; Bolz, O; Borrel, V; Braun, I; Breitling, F; Brown, A M; Buhler, R; Büsching, I; Carrigan, S; Chadwick, P M; Chounet, L M; Cornils, R; Costamante, L; Degrange, B; Dickinson, H J; Djannati-Ata, A; O'Connor-Drury, L; Dubus, G; Egberts, K; Emmanoulopoulos, D; Espigat, P; Feinstein, F; Ferrero, E; Fiasson, A; Fontaine, G; Funk, Seb; Funk, S; Gallant, Y A; Giebels, B; Glicenstein, J F; Goret, P; Hadjichristidis, C; Hauser, D; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hofmann, W; Holleran, M; Horns, D; Jacholkowska, A; De Jager, O C; Khelifi, B; Komin, N; Konopelko, A; Kosack, K; Latham, I J; Le Gallou, R; Lemiere, A; Lemoine-Goumard, M; Lohse, T; Martin, J M; Martineau-Huynh, O; Marcowith, A; Masterson, C; McComb, T J L; De Naurois, Mathieu; Nedbal, D; Nolan, S J; Noutsos, A; Orford, K J; Osborne, J L; Ouchrif, M; Panter, M; Pelletier, G; Pita, S; Pühlhofer, G; Punch, M; Raubenheimer, B C; Raue, M; Rayner, S M; Reimer, A; Reimer, O; Ripken, J; Rob, L; Rolland, L; Rowell, G; Sahakian, V V; Sauge, L; Schlenker, S; Schlickeiser, R; Schwanke, U; Sol, H; Spangler, D; Spanier, F; Steenkamp, R; Stegmann, C; Superina, G; Tavernet, J P; Terrier, R; Theoret, C G; Tluczykont, M; Van Eldik, C; Vasileiadis, G; Venter, C; Vincent, P; Völk, H J; Wagner, S J; Ward, M; al, et

    2006-01-01

    The detection of gamma-rays from the source HESS J1745-290 in the Galactic Center (GC) region with the H.E.S.S. array of Cherenkov telescopes in 2004 is presented. After subtraction of the diffuse gamma-ray emission from the GC ridge, the source is compatible with a point-source with spatial extent less than 1.2'(stat.) (95% CL). The measured energy spectrum above 160 GeV is compatible with a power-law with photon index of 2.25 +/- 0.04(stat.) +/- 0.10 (syst.) and no significant flux variation is detected. These measurements are discussed in the framework of dark matter annihilation. It is found that the bulk of the VHE emission must have non-dark-matter origin. Loose constraints on the velocity-weighted annihilation cross section are derived assuming the presence of an astrophysical non-dark-matter gamma-ray contribution.

  3. Chemical and structural analysis of Eucalyptus globulus and E. camaldulensis leaf cuticles: a lipidized cell wall region

    Directory of Open Access Journals (Sweden)

    Paula eGuzmán

    2014-09-01

    Full Text Available The plant cuticle has traditionally been conceived as an independent hydrophobic layer that covers the external epidermal cell wall. Due to its complexity, the existing relationship between cuticle chemical composition and ultra-structure remains unclear to date. This study aimed to examine the link between chemical composition and structure of isolated, adaxial leaf cuticles of Eucalyptus camaldulensis and E. globulus by the gradual extraction and identification of lipid constituents (cutin and soluble lipids, coupled to spectroscopic and microscopic analyses. The soluble compounds and cutin monomers identified could not be assigned to a concrete internal cuticle ultra-structure. After cutin depolymerization, a cellulose network resembling the cell wall was observed, with different structural patterns in the regions ascribed to the cuticle proper and cuticular layer, respectively. Our results suggest that the current cuticle model should be revised, stressing the presence and major role of cell wall polysaccharides. It is concluded that the cuticle may be interpreted as a modified cell wall region which contains additional lipids. The major heterogeneity of the plant cuticle makes it difficult to establish a direct link between cuticle chemistry and structure with the existing methodologies.

  4. Chemical and structural analysis of Eucalyptus globulus and E. camaldulensis leaf cuticles: a lipidized cell wall region.

    Science.gov (United States)

    Guzmán, Paula; Fernández, Victoria; Graça, José; Cabral, Vanessa; Kayali, Nour; Khayet, Mohamed; Gil, Luis

    2014-01-01

    The plant cuticle has traditionally been conceived as an independent hydrophobic layer that covers the external epidermal cell wall. Due to its complexity, the existing relationship between cuticle chemical composition and ultra-structure remains unclear to date. This study aimed to examine the link between chemical composition and structure of isolated, adaxial leaf cuticles of Eucalyptus camaldulensis and E. globulus by the gradual extraction and identification of lipid constituents (cutin and soluble lipids), coupled to spectroscopic and microscopic analyses. The soluble compounds and cutin monomers identified could not be assigned to a concrete internal cuticle ultra-structure. After cutin depolymerization, a cellulose network resembling the cell wall was observed, with different structural patterns in the regions ascribed to the cuticle proper and cuticular layer, respectively. Our results suggest that the current cuticle model should be revised, stressing the presence and major role of cell wall polysaccharides. It is concluded that the cuticle may be interpreted as a modified cell wall region which contains additional lipids. The major heterogeneity of the plant cuticle makes it difficult to establish a direct link between cuticle chemistry and structure with the existing methodologies.

  5. Ion and neutral temperature distributions in the E-region observed by the EISCAT Tromsø and Svalbard radars

    Directory of Open Access Journals (Sweden)

    S. Maeda

    Full Text Available Simultaneous Common Program Two experiments by the EISCAT UHF radar at Tromsø and the EISCAT Svalbard radar at Longyearbyen from 00:00 to 15:00 UT on 22 September 1998 and 9 March 1999 have been utilized to investigate distributions of the ion and neutral temperatures in the E-region between 105 and 115 km. During the experiments, soft particle precipitations in the dayside cusp were observed over the Svalbard radar site by the Defense Meteorological Satellite Program (DMSP F11 satellite. It is found that the dayside electric field in the regions of the low-latitude boundary of the polar cap and the cusp was greater and more variable than that in the auroral region. The ion temperature, parallel to the geomagnetic field at Longyearbyen, was higher than that at Tromsø during the daytime from 06:00 to 12:00 UT. The steady-state ion energy equation has been applied to derive neutral temperature under the assumption of no significant heat transport and viscous heating. The estimated neutral temperature at Longyearbyen was also higher than that at Tromsø. The ion and neutral energy budget was discussed in terms of the ion frictional heating and the Joule heating. The results indicate two possibilities: either the neutral temperature was high in the low latitude boundary of the polar cap and the cusp, or the heat transport by the polar cap neutral winds toward the dayside sector was significant.

    Key words. Ionosphere (auroral ionosphere; ionosphere–atmosphere interactions; polar ionosphere

  6. Attributes for MRB_E2RF1 Catchments by Major River Basins in the Conterminous United States: Hydrologic Landscape Regions

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This tabular data set represents the area of Hydrologic Landscape Regions (HLR) compiled for every MRB_E2RF1 catchment of the Major River Basins (MRBs, Crawford and...

  7. Melhoramento do Cafeeiro: XXI - Comportamento regional de variedades. Linhagens e progênies de café ao sol e à sombra Coffee Breeding: XXI - Regional behaviour of coffee varieties, strains and progenies under shaded and unshaded conditions.

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1961-01-01

    geral, que as progenies e linhagens reagiram, de maneira semelhante ao sol e à sombra, no sentido de que as mais promissoras ao sol também tendem a dar boa produção à sombra.During 1945 and 1947, five regional coffee trials were established at experimental stations of the Instituto Agronômico located, respectively, in Campinas, Ribeirão Prêto, Pindorama, Mococa and Jaú comprising 25 selected entries, among which varieties, strains (mixture of seeds of several plants of a single progeny and progenies of selected coffee plants. These trials were planted in three replications of a balanced square lattice 5x5, without any shade and three other replications under shade of Inga edulis. Temporary shade was provided in shaded plots by other shade tree species. During the first years, missing plants occurred more frequently in Ribeirão Prêto and Pindorama. In 1956, at the end of the first phase of these trials, it was observed that the number of misses was higher in Jaú and lower in Campinas. A larger number of misses always occurred in the three replications under shade. Progenies and strains of Sumatra, Laurina and Caturra cultivars and of the Bourbon Vermelho n. 44, presented the highest number of misses in all localities. The average height of the plants, taken as an index of vegetative growth, was lower in the shaded replications in the trial of Ribeirão Prêto. In all other localities, the average height was practically the same under both environments. It was also observed that most plants continued to grow in height by the end of the first phase of the experiments (12 years old. In the shaded plots, most plants had a more reduced secondary and terciary branching, which probably contributed to the lower total yield. The yield, in kilograms of ripe fruits, was a determined for each plot during this period of time. However, in order to simplify the discussion, only the total yields of the 9 years for Campinas and Pindorama and 8 years of consecutive yields for

  8. Estimation of electron density in ionospheric D and E regions using MF radar: Inspection of DAE algorism

    Science.gov (United States)

    Ashihara, Y.; Miyake, T.; Ishisaka, K.; Murayama, Y.; Kawamura, S.; Nagano, I.; Okada, T.

    2006-12-01

    MF radar estimates the electron density in lower ionospheric D and E regions at the altitude from 60km to 100km by using the partial reflection information of MF radar transmission wave. Though, the electron density in ionospheric D region is very small, about 10-1000 /cc, electrons are closely related to neutral dynamic meteorology and chemistry including such as hydrated ion and NOx in the region. Therefore, it has the possibility to find a new physical knowledge in mesosphere and lower ionosphere. MF Rader transmits the burst pulse radio wave toward vertically direction. This pulse has 48μsec. width and modulated by 1.995MHz. Differential Absorption Experiment (DAE) is one of the methods to estimate the electron density by MF radar. DAE needs three information, which are ratio of received intensity, reflection coefficient and attenuate coefficient. Ratio of received intensity is found by the differential amount of between the left and the right polarized wave reflected by ionosphere. Though, reflection and attenuation coefficient are given as constant which is only depended on altitude, and is not depended on electron or atmospheric density. The validity of DAE has not been examined for more than 30 years. So we examine the validity of treatment both refection and attenuation coefficient as constant. Full wave analysis is a simulation method to calculate the radio wave propagation characteristics in ionosphere. Though, MF radar transmitted pulse must be treated in the time-domain. In this study, we obtain the time development of MF radar transmitted pulse by applying Fourier transformation to Full wave analysis on simulation. It is required some parameters, electron density profile, neutral-electron collision frequency profile, etc., to execute Full wave analysis. This time development data of MF radar transmitted pulse includes the reflection pulse, i.e. ratio of received intensity, at the ionosphere. We can calculate electron density profile by DAE method

  9. Comércio interestadual por vias internas e integração regional no Brasil: 1943-69

    Directory of Open Access Journals (Sweden)

    Olímpio J. de Arroxelas Galvão

    1999-12-01

    Full Text Available Este artigo tem dois objetivos. Primeiro, o de fornecer suporte técnico empírico à tradicional assertiva de que o Brasil ainda constituía um ''arquipélago'' de ilhas econômicas, até pelo menos o final da década de 40. Segundo, o de descrever as relações comerciais entre os estados e as regiões brasileiras nas décadas que imediatamente precederam e sucederam a fase de aceleração do processo de integração de mercados no país. O artigo mostra, utilizando quatro matrizes de comércio interestadual, que foi apenas após a efetivação de um programa nacional de construção de rodovias, nos anos 50 e 60, que o Brasil rompeu, de fato, com o estado de relativo isolamento de suas economias regionais. A impressionante expansão dos fluxos do comércio interestadual, a partir dos anos 50, evidencia a notável intensificação das articulações inter-regionais, propiciando a formação de um mercado nacional virtualmente unificado.This paper has two main objectives. First, to provide empirical support to the traditional assertive that Brazil still constituted an ''archipelago'' of economic islands until at least the end of the 40's. Second, to describe the commercial relationships among the Brazilian states and regions in the decades which immediately preceded and succeeded the face of acceleration in the process of market integration in the country. The paper shows, by making use of four interstate trade matrices, that only after the completion of a national program of roadways construction, in the 50's and 60's, Brazil effectively broke up the state of relative isolation of its regional economies. The impressive expansion of the internal trade flows, starting in the 50's, attests to the striking intensification of the integration process and the formation of a virtually unified national market.

  10. Aerogammaspectrometric anomalies (K, eU and eTh) from Araras region (SP) and its relations with pedogenetic processes and phosphate fertilizers; Anomalias aerogamaespectrometricas (K, eU e eTh) da quadricula de Araras (SP) e suas relacoes com processos pedogeneticos e fertilizantes fosfatos

    Energy Technology Data Exchange (ETDEWEB)

    Souza, Jocelyn Lopes de; Ferreira, Francisco Jose Fonseca, E-mail: jocelyn_informatica@yahoo.com.br, E-mail: jocelyn.souza@utp.br, E-mail: francisco.ferreira@ufpr.br [Universidade Federal do Parana (LPGA/UFPR), Curitiba, PR (Brazil). Dept. de Geologia. Lab. de Pesquisas em Geofisica Aplicada

    2005-07-15

    Radionuclides are present in the raw materials utilized in the manufacturing of some fertilizers and, consequently, the redistribution of uranium, thorium and potassium by agricultural activities may lead to the contamination of intensively fertilized soils. Airborne gamma-ray data on K, eU and Th have shown the coincidence of aerogammaspectrometric anomalies and diabase sills in the Araras region (SP). This area is situated between the coordinates latitude 22 deg 00'/22 deg 30' South and longitude 47 deg 00' and 47 deg 30' West. As the contents of radionuclides in basic rocks are low and aerial gamma-ray surveys reveal gamma radiation from the 30 cm of the soil profile (coinciding with topsoil), interest has been raised to investigate which soils are included in the anomalies reported, as well as what sort of agricultural activity is carried out, in order to attest whether the source of radioactivity originated from the chemical fertilizers applied, thus establishing the main purpose of the present research. Integration by GIS has revealed that (1) eU and eTh anomalies occur on latossolos roxos massively fertilized with phosphates, on the level and elevated parts of the terrain; (2) high levels of uranium are associated with clay particle size in regoliths developed on diabase sills; (3) potassium and thorium anomalies follow Quaternary alluviums which extend along the banks of the Moji river, the occurrence of anomalous K accounting for the presence of feldspars in the included soils, and the occurrence of eTh related to local fertilization and to the transport of clays and iron oxides from the uppermost parts of the terrain, where the Latossolos Roxos under sugarcane are located. Radiochemical analyses of U and Th in fertilizers were in agreement with the literature, and it has been observed the influence of the geological genesis of the source of the raw material utilized in the production of the fertilizer, as well as the increase in

  11. EAS spectrum in the primary energy region above 10 to the 15th power eV by the Akeno and Yakutsk array data

    Science.gov (United States)

    Krasilnikov, D. D.; Knurenko, S. P.; Krasilnikov, A. D.; Pavlov, V. N.; Sleptsov, I. Y.; Yegorova, V. P.

    1985-01-01

    The extensive air showers spectrum on scintillation desity Rko in primary energy region E sub approx. 10 to the 15th power - 10 to the 20th power eV on the Yakutsk array data and recent results of the Akeno is given.

  12. Preferências dos ouvintes em relação ao sotaque regional em contexto formal e informal de comunicação

    Directory of Open Access Journals (Sweden)

    Leonardo Wanderley Lopes

    2014-06-01

    Full Text Available Objetivo analisar as preferências dos ouvintes quanto ao sotaque regional e sotaque suavizado em contexto formal e informal de comunicação. Métodos três telejornalistas gravaram frases-veículo nas situações de sotaque regional e suavizado. As gravações foram apresentadas a 105 juízes, que escutaram os pares de palavras e responderam qual das duas pronúncias preferiam para a fala de apresentadores de telejornal (contexto formal, para falantes nativos da comunidade local (contexto informal e para a própria fala (contexto informal. Resultados os ouvintes preferiram a presença de sotaque suavizado em contexto formal (apresentação de telejornal em todas as variantes linguísticas estudadas (p<0,0001 e, por outro lado, preferiram a presença de sotaque regional (p<0,0001 em contexto informal. Porém, para a própria fala, dentro do contexto informal, não houve uma preferência geral pelo sotaque regional ou suavizado, havendo significância estatística apenas para palatalização do /S/ em coda medial (p<0,0001 e não palatalização das dentais (p<0,0001, ambas características do sotaque regional, e a não ocorrência de monotongação (p<0,0001 e harmonização vocálica (p<0,0001, caracterizados como sotaque suavizado. Conclusão os ouvintes preferem à fala com sotaque suavizado em um contexto formal de comunicação, mas preferem o sotaque regional dentro de um contexto informal, principalmente em falantes menos escolarizados.

  13. Gyrokinetic Studies of Turbulence in Steep Gradient Region: Role of Turbulence Spreading and E x B Shear

    Energy Technology Data Exchange (ETDEWEB)

    T.S. Hahm; Z. Lin; P.H. Diamond; G. Rewoldt; W.X. Wang; S. Ethier; O. Gurcan; W.W. Lee; W.M. Tang

    2004-12-21

    An integrated program of gyrokinetic particle simulation and theory has been developed to investigate several outstanding issues in both turbulence and neoclassical physics. Gyrokinetic particle simulations of toroidal ion temperature gradient (ITG) turbulence spreading using the GTC code and its related dynamical model have been extended to the case with radially increasing ion temperature gradient, to study the inward spreading of edge turbulence toward the core. Due to turbulence spreading from the edge, the turbulence intensity in the core region is significantly enhanced over the value obtained from simulations of the core region only. Even when the core gradient is within the Dimits shift regime (i.e., self-generated zonal flows reduce the transport to a negligible value), a significant level of turbulence and transport is observed in the core due to spreading from the edge. The scaling of the turbulent front propagation speed is closer to the prediction from our nonlinear diffusion model than one based on linear toroidal coupling. A calculation of ion poloidal rotation in the presence of sharp density and toroidal angular rotation frequency gradients from the GTC-Neo particle simulation code shows that the results are significantly different from the conventional neoclassical theory predictions. An energy conserving set of a fully electromagnetic nonlinear gyrokinetic Vlasov equation and Maxwell's equations, which is applicable to edge turbulence, is being derived via the phase-space action variational Lie perturbation method. Our generalized ordering takes the ion poloidal gyroradius to be on the order of the radial electric field gradient length.

  14. Virulence profile of different phylogenetic groups of locally isolated community acquired uropathogenic E. coli from Faisalabad region of Pakistan

    Directory of Open Access Journals (Sweden)

    Bashir Saira

    2012-08-01

    Full Text Available Abstract Background Uropathogenic E.coli (UPEC are among major pathogens causing urinary tract infections. Virulence factors are mainly responsible for the severity of these emerging infections. This study was planned to investigate the distribution of virulence genes and cytotoxic effects of UPEC isolates with reference to phylogenetic groups (B2, B1, D and A to understand the presence and impact of virulence factors in the severity of infection in Faisalabad region of Pakistan. Methods In this study phylogenetic analysis, virulence gene identification and cytotoxicity of 59 uropathogenic E.coli isolates obtained from non-hospitalized patients was studied. Results Among 59 isolates, phylogenetic group B2 (50% was most dominant followed by groups A, B1 (19% each and D (12%. Isolates present in group D showed highest presence of virulence genes. The prevalence hlyA (37% was highest followed by sfaDE (27%, papC (24%, cnf1 (20%, eaeA (19% and afaBC3 (14%. Highly hemolytic and highly verotoxic isolates mainly belonged to group D and B2. We also found two isolates with simultaneous presence of three fimbrial adhesin genes present on pap, afa, and sfa operons. This has not been reported before and underlines the dynamic nature of these UPEC isolates. Conclusions It was concluded that in local UPEC isolates from non-hospitalized patients, group B2 was more prevalent. However, group D isolates were most versatile as all were equipped with virulence genes and showed highest level of cytotoxicity.

  15. A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3.

    Science.gov (United States)

    Méthot, N; Song, M S; Sonenberg, N

    1996-01-01

    The binding of mRNA to the ribosome is mediated by eukaryotic initiation factors eukaryotic initiation factor 4F (eIF4F), eIF4B, eIF4A, and eIF3, eIF4F binds to the mRNA cap structure and, in combination with eIF4B, is believed to unwind the secondary structure in the 5' untranslated region to facilitate ribosome binding. eIF3 associates with the 40S ribosomal subunit prior to mRNA binding. eIF4B copurifies with eIF3 and eIF4F through several purification steps, suggesting the involvement of a multisubunit complex during translation initiation. To understand the mechanism by which eIF4B promotes 40S ribosome binding to the mRNA, we studied its interactions with partner proteins by using a filter overlay (protein-protein [far Western]) assay and the two-hybrid system. In this report, we show that eIF4B self-associates and also interacts directly with the p170 subunit of eIF3. A region rich in aspartic acid, arginine, tyrosine, and glycine, termed the DRYG domain, is sufficient for self-association of eIF4B, both in vitro and in vivo, and for interaction with the p170 subunit of eIF3. These experiments suggest that eIF4B participates in mRNA-ribosome binding by acting as an intermediary between the mRNA and eIF3, via a direct interaction with the p170 subunit of eIF3. PMID:8816444

  16. Mediterranean region`s LNG industry. Algeria and Libya to Spain, France, Italy and Turkey; Chichukai chiiki no LNG sangyo. Arujeria, Ribia kara Supein, Furansu, Itaria, Toruko e

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-08-10

    Since LNG is used along with gas supply in mediterranean region, the amount of LNG use in that region is very small in comparison with total demand. However imported LNG for peak use during winter and use as industrial raw materials occupies very important part in Spain, France etc., and other importing countries. From this, further increase of LNG trade is expected. Information regarding operating conditions of plants and liquefaction ability, present conditions of base plant construction and its special features, history of oil/gas fields and LNG supply contracts with importing countries is provided for LNG exporting countries like Libya and Algeria in mediterranean region. Storage base`s scale (site area, tank capacity and ship logging`s load capacity) and period until operation starts are reported along with information before import for importing countries like Spain, France, Italy and Turkey. Further trend of base storage for Greece and Turkey will be surveyed here after.

  17. Prevalência de sobrepeso e obesidade em crianças e adolescentes das regiões Sudeste e Nordeste Overweight and obesity prevalence among children and adolescents from Northeast and Southeast regions of Brazil

    Directory of Open Access Journals (Sweden)

    Marcelo M. Abrantes

    2002-01-01

    Full Text Available Objetivo: estudar a prevalência de sobrepeso e obesidade em crianças e adolescentes da região Sudeste e Nordeste. Métodos: dados da pesquisa sobre padrões de vida, realizada pelo Instituto Brasileiro de Geografia e Estatística (IBGE em 1997. Estudadas 3.317 crianças e 3.943 adolescentes agrupados em faixas etárias. Sobrepeso (adolescentes e obesidade (crianças e adolescentes foram definidos segundo recomendações da Organização Mundial de Saúde. Comparação de prevalências por faixa etária, sexo e região geográfica pelo teste z, considerando 0,05 como nível de significância estatística. Resultados: a prevalência de sobrepeso em adolescentes variou entre 1,7% no Nordeste, e 4,2% no Sudeste. A prevalência de obesidade em adolescentes variou entre 6,6% e 8,4%, e em crianças entre 8,2% e 11,9%, nas regiões Nordeste e Sudeste, respectivamente. Agrupando-se os dados das duas regiões, a prevalência no sexo feminino foi de 10,3% de obesidade entre crianças, 9,3% de obesidade e 3,0% de sobrepeso entre adolescentes. No sexo masculino, a prevalência foi de 9,2%, 7,3% e 2,6%, respectivamente. Conclusões: a prevalência de obesidade é menor no Nordeste, com significância estatística entre crianças e adolescentes com idade entre 2-17 anos. O mesmo ocorreu com a prevalência de sobrepeso entre os adolescentes. A diferença de prevalência de obesidade entre lactentes e adolescentes acima de 18 anos não foi estatisticamente significante. Entre lactentes, a obesidade é mais prevalente no sexo feminino. Nas outras faixas etárias, não houve diferença estatisticamente significante entre os sexos. A comparação dos resultados com os de outros estudos é difícil pela diversidade de critérios utilizados na classificação nutricional.Objective: to study the prevalence of obesity and overweight among children and adolescents from Northeast and Southeast regions of Brazil. Methods: data was collected form Life Pattern Research

  18. A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus

    Science.gov (United States)

    Yang, Yonglin; Lin, Shaoli; Nan, Yuchen; Ma, Zexu; Yang, Liping; Zhang, Yanjin

    2016-01-01

    Hepatitis E virus (HEV) is one of the viral pathogens causing hepatitis in humans. HEV open reading frame 3 (ORF3) encodes a small multifunctional protein (VP13), which is essential for HEV infection. In this study, a linear epitope was identified in a polyproline (PXXP) motif from VP13 of genotype 1 HEV by using a monoclonal antibody. The epitope was detected in enzyme-linked immunosorbent assay (ELISA), immunoblotting and immunofluorescence assays. Epitope mapping showed that the epitope locates in a proline-rich region containing a PXXP motif in amino acid residues 66-75 of VP13. The epitope was also detected in HEV-infected liver cells and reacted with genotype 1-specific antibodies in an HEV-positive human serum sample. The results demonstrated that the epitope in the PXXP motif of the genotype 1 VP13 is linear and surface-oriented, which should facilitate in-depth studies on the viral protein and HEV biology. PMID:27548202

  19. A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus

    Directory of Open Access Journals (Sweden)

    Yonglin Yang

    2016-08-01

    Full Text Available Hepatitis E virus (HEV is one of the viral pathogens causing hepatitis in humans. HEV open reading frame 3 (ORF3 encodes a small multifunctional protein (VP13, which is essential for HEV infection. In this study, a linear epitope was identified in a polyproline (PXXP motif from VP13 of genotype 1 HEV by using a monoclonal antibody. The epitope was detected in enzyme-linked immunosorbent assay (ELISA, immunoblotting and immunofluorescence assays. Epitope mapping showed that the epitope locates in a proline-rich region containing a PXXP motif in amino acid residues 66-75 of VP13. The epitope was also detected in HEV-infected liver cells and reacted with genotype 1-specific antibodies in an HEV-positive human serum sample. The results demonstrated that the epitope in the PXXP motif of the genotype 1 VP13 is linear and surface-oriented, which should facilitate in-depth studies on the viral protein and HEV biology.

  20. Polarized structure function σLT' for H1(e→,e'K+)Λ in the nucleon resonance region

    Science.gov (United States)

    Nasseripour, R.; Raue, B. A.; Carman, D. S.; Ambrozewicz, P.; Amaryan, M. J.; Anciant, E.; Anghinolfi, M.; Asavapibhop, B.; Asryan, G.; Audit, G.; Auger, T.; Avakian, H.; Bagdasaryan, H.; Baillie, N.; Ball, J. P.; Baltzell, N. A.; Barrow, S.; Battaglieri, M.; Beard, K.; Bedlinskiy, I.; Bektasoglu, M.; Bellis, M.; Benmouna, N.; Berman, B. L.; Biselli, A. S.; Blaszczyk, L.; Bonner, B. E.; Bouchigny, S.; Boiarinov, S.; Bradford, R.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Butuceanu, C.; Calarco, J. R.; Careccia, S. L.; Casey, L.; Cetina, C.; Chen, S.; Cheng, L.; Cole, P. L.; Collins, P.; Coltharp, P.; Cords, D.; Corvisiero, P.; Crabb, D.; Crede, V.; Dale, D.; Dashyan, N.; Masi, R. De; Vita, R. De; Sanctis, E. De; Degtyarenko, P. V.; Dennis, L.; Deur, A.; Dhuga, K. S.; Dickson, R.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dragovitsch, P.; Dugger, M.; Dytman, S.; Dzyubak, O. P.; Egiyan, H.; Egiyan, K. S.; Fassi, L. El; Elouadrhiri, L.; Eugenio, P.; Fatemi, R.; Fedotov, G.; Feldman, G.; Feuerbach, R. J.; Forest, T. A.; Fradi, A.; Funsten, H.; Garçcon, M.; Gavalian, G.; Gevorgyan, N.; Gilfoyle, G. P.; Giovanetti, K. L.; Girard, P.; Girod, F. X.; Goetz, J. T.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guillo, M.; Guler, N.; Guo, L.; Gyurjyan, V.; Hafidi, K.; Hakobyan, H.; Hanretty, C.; Hardie, J.; Heddle, D.; Hersman, F. W.; Hicks, K.; Hleiqawi, I.; Holtrop, M.; Hu, J.; Hyde-Wright, C. E.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Ito, M. M.; Jenkins, D.; Jo, H. S.; Johnstone, J. R.; Joo, K.; Juengst, H. G.; Kalantarians, N.; Kellie, J. D.; Khandaker, M.; Kim, K. Y.; Kim, K.; Kim, W.; Klein, A.; Klein, F. J.; Kossov, M.; Krahn, Z.; Kramer, L. H.; Kubarovsky, V.; Kuhn, J.; Kuhn, S. E.; Kuleshov, S. V.; Kuznetsov, V.; Lachniet, J.; Laget, J. M.; Langheinrich, J.; Lawrence, D.; Livingston, K.; Lu, H. Y.; Lukashin, K.; MacCormick, M.; Manak, J. J.; Markov, N.; Mattione, P.; McAleer, S.; McKinnon, B.; McNabb, J. W. C.; Mecking, B. A.; Mestayer, M. D.; Meyer, C. A.; Mibe, T.; Mikhailov, K.; Minehart, R.; Mirazita, M.; Miskimen, R.; Mokeev, V.; Moreno, B.; Moriya, K.; Morrow, S. A.; Moteabbed, M.; Mueller, J.; Munevar, E.; Mutchler, G. S.; Nadel-Turonski, P.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niczyporuk, B. B.; Niroula, M. R.; Niyazov, R. A.; Nozar, M.; Osipenko, M.; Ostrovidov, A. I.; Park, K.; Pasyuk, E.; Paterson, C.; Pereira, S. Anefalos; Peterson, G.; Philips, S. A.; Pierce, J.; Pivnyuk, N.; Pocanic, D.; Pogorelko, O.; Pozdniakov, S.; Preedom, B. M.; Price, J. W.; Procureur, S.; Prok, Y.; Protopopescu, D.; Qin, L. M.; Riccardi, G.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Rosner, G.; Rossi, P.; Rubin, P. D.; Sabatié, F.; Salamanca, J.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Sayre, D.; Schumacher, R. A.; Serov, V. S.; Shafi, A.; Sharabian, Y. G.; Sharov, D.; Shvedunov, N. V.; Simionatto, S.; Skabelin, A. V.; Smith, E. S.; Smith, L. C.; Sober, D. I.; Sokhan, D.; Stavinsky, A.; Stepanyan, S. S.; Stepanyan, S.; Stokes, B. E.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Taylor, S.; Tedeschi, D. J.; Thompson, R.; Tkabladze, A.; Tkachenko, S.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Wang, K.; Watts, D. P.; Weinstein, L. B.; Weygand, D. P.; Williams, M.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Yun, J.; Zana, L.; Zhang, J.; Zhao, B.; Zhao, Z. W.

    2008-06-01

    The first measurements of the polarized structure function σLT' for the reaction H1(e→,e'K+)Λ in the nucleon resonance region are reported. Measurements are included from threshold up to W=2.05 GeV for central values of Q2 of 0.65 and 1.00 GeV2, and nearly the entire kaon center-of-mass angular range. σLT' is the imaginary part of the longitudinal-transverse response and is expected to be sensitive to interferences between competing intermediate s-channel resonances, as well as resonant and nonresonant processes. The results for σLT' are comparable in magnitude to previously reported results from CLAS for σLT, the real part of the same response. An intriguing sign change in σLT' is observed in the high Q2 data at W≈1.9 GeV. Comparisons to several existing model predictions are shown.

  1. The Effort to Create Customer Engagement on Customer E_Banking (Empirical Studies on Bank BNI Regional Semarang

    Directory of Open Access Journals (Sweden)

    Alimuddin Rizal Rivai

    2016-12-01

    Full Text Available                     This study focused on testing the effect of variable customer value, support systems and knowledge of the customer's products to customer satisfaction and its impact on customer engagement. This study selects the object user's e-banking customers of Bank BNI Regional Semarang. The number of samples in this study of 100 respondents, using purposive sampling technique sampling. Processing data using SPSS version 16.0. Based on a statistical test using linear regression approach, then of seven hypothesis there are two hypotheses were rejected. The hypothesis is rejected is the influence of customer value on customer engagement, and support systems to customer engagement. While five other hypotheses, namely: the influence of the customer value, support systems, knowledge products to the satisfaction of the customer, as well as the effect of product knowledge and customer satisfaction on customer involvement is proven. Based on the results of this study, it can be concluded that to build customer engagement should be created customer satisfaction. While such satisfaction can be created through providing better customer value, the support system is up to date and easy, and provides knowledge products to customers continuously and thoroughly.

  2. Distribution of K, eU and Th and evaluation of annual radiation dose in the region of the Serra do Carambei Granite - PR; Distribuicao de K, eU e eTh e avaliacao da dose anual de radiacao na regiao do Granito Serra do Carambei - PR

    Energy Technology Data Exchange (ETDEWEB)

    Godoy, Luiz C., E-mail: luizcgodoy@brturbo.com.br [Departamento de Geociencias, Universidade Estadual de Ponta Grossa, PR (Brazil); Bittencourt, Andre V.L., E-mail: andre@ufpr.br [Laboratorio de Pesquisas Hidrogeologicas - LPH, Departamento de Geologia, Universidade Federal do Parana, Centro Politecnico, Curitiba, PR (Brazil); Santos, Leonardo J.C., E-mail: santos@ufpr.br [Laboratorio de Biogeografia e Solos - LABS, Departamento de Geografia, Universidade Federal do Parana, Centro Politecnico, Curitiba, PR (Brazil); Ferreira, Francisco J.F., E-mail: francisco.ferreira@ufpr.br [Laboratorio de Pesquisas em Geofisica Aplicada - LPGA, Departamento de Geologia, Universidade Federal do Parana, Centro Politecnico, Curitiba, PR (Brazil)

    2011-04-15

    is study was conducted in an area of 14 km in length oriented in the NNE direction by 7.3 km wide, covering the totality of the Serra do Carambei Granite and adjacent units. Located in the northern region of the Alagados dam, Parana State, this granite contains relatively high concentrations of K, eU and eTh, known since the 1970s through airborne and terrestrial gamma-ray spectrometry surveys. Recent radiochemical tests conducted on 61 samples of geological materials such as rocks (17 samples) and material of the weathering mantle and alluvial deposits (44 samples), confirmed the occurrence of radioactive anomalies in this granite, especially in thorium and uranium. The contents of K, eU and eTh obtained in gamma-ray spectrometry survey and radiochemical tests, converted to annual radiation dose (ARD), allowed to evaluate the intensity of natural radiation, whose levels relatively high in certain regions of the study area, can offer hazard to the local populations. The analysis and interpretation of data, as well the preparation of contour maps of K, eU and eTh were fundamental to understand the behavior and mobility of radionuclides in different environmental compartments of the area. (author)

  3. Evaluation of Enhanced High Resolution MODIS/AMSR-E SSTs and the Impact on Regional Weather Forecast

    Science.gov (United States)

    Schiferl, Luke D.; Fuell, Kevin K.; Case, Jonathan L.; Jedlovec, Gary J.

    2010-01-01

    Over the last few years, the NASA Short-term Prediction Research and Transition (SPoRT) Center has been generating a 1-km sea surface temperature (SST) composite derived from retrievals of the Moderate Resolution Imaging Spectroradiometer (MODIS) for use in operational diagnostics and regional model initialization. With the assumption that the day-to-day variation in the SST is nominal, individual MODIS passes aboard the Earth Observing System (EOS) Aqua and Terra satellites are used to create and update four composite SST products each day at 0400, 0700, 1600, and 1900 UTC, valid over the western Atlantic and Caribbean waters. A six month study from February to August 2007 over the marine areas surrounding southern Florida was conducted to compare the use of the MODIS SST composite versus the Real-Time Global SST analysis to initialize the Weather Research and Forecasting (WRF) model. Substantial changes in the forecast heat fluxes were seen at times in the marine boundary layer, but relatively little overall improvement was measured in the sensible weather elements. The limited improvement in the WRF model forecasts could be attributed to the diurnal changes in SST seen in the MODIS SST composites but not accounted for by the model. Furthermore, cloud contamination caused extended periods when individual passes of MODIS were unable to update the SSTs, leading to substantial SST latency and a cool bias during the early summer months. In order to alleviate the latency problems, the SPoRT Center recently enhanced its MODIS SST composite by incorporating information from the Advanced Microwave Scanning Radiometer-EOS (AMSR-E) instruments as well as the Operational Sea Surface Temperature and Sea Ice Analysis. These enhancements substantially decreased the latency due to cloud cover and improved the bias and correlation of the composites at available marine point observations. While these enhancements improved upon the modeled cold bias using the original MODIS SSTs

  4. Água e integração regional na África ocidental: Papel dos rios na economia política oeste africana / Water and Regional Integration in West Africa: Role of rivers in the west

    OpenAIRE

    Diallo, Mamadou Alpha; Universidade Federal do Rio Grande do Sul

    2013-01-01

    Este artigo parte da descrição histórica dos diferentes processos sociopolíticos, econômicos e culturais que se desenvolvem no curso do rio Senegal, para avaliar os possíveis conflitos de interesses políticos e econômicos e suas consequências positivas ou negativas para a integração regional dos países da região. Conclui-se que os rios são elementos favoráveis à promoção da cooperação e da integração regional na África Ocidental, apesar de certas tensões existirem entre Estados separados por ...

  5. Possible relationship between the equatorial electrojet (EEJ) and daytime vertical E × B drift velocities in F region from ROCSAT observations

    Science.gov (United States)

    Kumar, Sandeep; Veenadhari, B.; Tulasi Ram, S.; Su, S.-Y.; Kikuchi, T.

    2016-10-01

    The vertical E × B drift is very important parameter as its day to day variability has great influence on the variability in the low latitude F-region ion and electron density distributions. The measurements of vertical ion velocity from the first Republic of China Satellite (ROCSAT-1) provide a unique data base for the development of possible relationship between vertical E × B drifts and ground based magnetometer observation. An attempt has been made to derive quantitative relationship between F-region vertical E × B drifts measured by ROCSAT-1 (600 km) and ground measured equatorial electrojet for the solar maximum period 2001-2003 for Indian and Japanese sectors. The results consistently indicate existence of linear relationship between the measured vertical E × B drifts at topside F-region and EEJ for both the sectors, with a moderate to high correlation coefficients. The linear relationship between ROCSAT-1 measured E × B drifts and EEJ for Indian and Japanese sectors has been compared with a similar relationship with Jicamarca Unattended Long-term Ionosphere Atmosphere Radar (JULIA) measured E × B drifts (150 km echos) and EEJ strength from Peruvian sector during 2003. It has been found that ROCSAT-1 measured E × B drifts shows linear relationship with EEJ, however, exhibits a larger scatter unlike JULIA radar observed E × B drifts. This may be attributed to the large height difference as ROCSAT-1 measures E × B drifts at 600 km altitude and the EEJ is E-region (110 km) phenomenon.

  6. Photovoltaic plants of PRODEEM, state of Sao Paulo, Brazil and a proposal for regional organization; Instalacoes fotovoltaicas do PRODEEM - Sao Paulo e uma proposta de organizacao regional

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Maria Julita Guerra; Campos, Ubirajara Sampaio de [Secretaria de Estado de Energia de Sao Paulo, SP (Brazil)

    1999-07-01

    This paper presents an overview on the Photovoltaic Systems for Water Pumping in Temporary Settlements in the State of Sao Paulo - Brazil project, submitted for approval of the Brazilian PRODEEM (Program for the Energetic Development of States and Municipal Districts). This project aims the electric power viability for rural workers settlement in the Pontal do Parapanema region, providing the water supply for families and cattle.

  7. Regionalização e acesso à saúde nos estados brasileiros: condicionantes históricos e político-institucionais Regionalization and access to healthcare in Brazilian states: historical and political-institutional conditioning factors

    Directory of Open Access Journals (Sweden)

    Luciana Dias de Lima

    2012-11-01

    Full Text Available O artigo aborda o processo de regionalização da saúde nos estados brasileiros no período de 2007 a 2010, com o objetivo de identificar as condições que favorecem ou dificultam esse processo. Utilizou-se o referencial de análise de políticas públicas e, particularmente, do institucionalismo histórico. Três dimensões sintetizam os condicionantes da regionalização: contexto (histórico-estrutural, político-institucional e conjuntural, direcionalidade (ideologia, objeto, atores, estratégias e instrumentos e características da regionalização (institucionalidade e governança. A pesquisa empírica privilegiou a análise de documentos oficiais e entrevistas com atores-chave em 24 estados. Observaram-se combinações de fatores e padrões de influência distintos nos estados, sendo a regionalização marcada por importantes ganhos de institucionalidade e governança no período. Entretanto, dificuldades inerentes aos contextos comprometem maiores avanços. Há necessidade de ampliar o enfoque territorial no planejamento governamental e integrar políticas setoriais ao desenvolvimento regional de médio e longo prazo para fortalecer a regionalização e superar entraves ao acesso aos serviços de saúde no Brasil.This article examines the healthcare regionalization process in the Brazilian states in the period from 2007 to 2010, seeking to identify the conditions that favor or impede this process. Referential analysis of public policies and especially of historical institutionalism was used. Three dimensions sum up the conditioning factors of regionalization: context (historical-structural, political-institutional and conjunctural, directionality (ideology, object, actors, strategies and instruments and regionalization features (institutionality and governance. The empirical research relied mainly on the analysis of official documents and interviews with key actors in 24 states. Distinct patterns of influence in the states were

  8. The Search for a Complex Molecule in a Selected Hot Core Region: A Rigorous Attempt to Confirm trans-Ethyl Methyl Ether toward W51 e1/e2

    CERN Document Server

    Carroll, P Brandon; Blake, Geoffrey A; Apponi, A J; Ziuyrs, L M; Remijan, Anthony

    2014-01-01

    An extensive search has been conducted to confirm transitions of \\textit{trans}-ethyl methyl ether (tEME, C$_2$H$_5$OCH$_3$), toward the high mass star forming region W51 e1/e2 using the 12 m Telescope of the Arizona Radio Observatory (ARO) at wavelengths from 2 mm and 3 mm. In short, we cannot confirm the detection of tEME toward W51 e1/e2 and our results call into question the initial identification of this species by \\citet{FuchsSpace}. Additionally, reevaluation of the data from the original detection indicates that tEME is not present toward W51 e1/e2 in the abundance reported by Fuchs and colleagues. Typical peak-to-peak noise levels for the present observations of W51 e1/e2 were between 10 - 30 mK, yielding an upper limit of the tEME column density of $\\leq$ 1.5 $\\times$ 10$^{15}$ cm$^{-2}$. This would make tEME at least a factor 2 times less abundant than dimethyl ether (CH$_3$OCH$_3$) toward W51 e1/e2. We also performed an extensive search for this species toward the high mass star forming region Sgr...

  9. Influence of uncertainties of the empirical models for inferring the E-region electric fields at the dip equator

    Science.gov (United States)

    Moro, Juliano; Denardini, Clezio Marcos; Resende, Laysa Cristina Araújo; Chen, Sony Su; Schuch, Nelson Jorge

    2016-06-01

    Daytime E-region electric fields play a crucial role in the ionospheric dynamics at the geomagnetic dip latitudes. Due to their importance, there is an interest in accurately measuring and modeling the electric fields for both climatological and near real-time studies. In this work, we present the daytime vertical ( Ez) and eastward ( Ey) electric fields for a reference quiet day (February 7, 2001) at the São Luís Space Observatory, Brazil (SLZ, 2.31°S, 44.16°W). The component Ez is inferred from Doppler shifts of type II echoes (gradient drift instability) and the anisotropic factor, which is computed from ion and electron gyro frequencies as well as ion and electron collision frequencies with neutral molecules. The component Ey depends on the ratio of Hall and Pedersen conductivities and Ez. A magnetic field-line-integrated conductivity model is used to obtain the anisotropic factor for calculating Ez and the ionospheric conductivities for calculating Ey. This model uses the NRLMSISE-00, IRI-2007, and IGRF-11 empirical models as input parameters for neutral atmosphere, ionosphere, and geomagnetic field, respectively. Consequently, it is worth determining the uncertainties (or errors) in Ey and Ez associated with these empirical model outputs in order to precisely define the confidence limit for the estimated electric field components. For this purpose, errors of ±10 % were artificially introduced in the magnitude of each empirical model output before estimating Ey and Ez. The corresponding uncertainties in the ionospheric conductivity and electric field are evaluated considering the individual and cumulative contribution of the artificial errors. The results show that the neutral densities and temperature may be responsible for the largest changes in Ey and Ez, followed by changes in the geomagnetic field intensity and electron and ions compositions.

  10. Parlamentos supranacionais na Europa e na América Latina: entre o fortalecimento e a irrelevância Regional parliaments in Europe and Latin America: between empowerment and irrelevance

    Directory of Open Access Journals (Sweden)

    Andrés Malamud

    2005-12-01

    Full Text Available Nenhum processo de integração regional está isento de críticas sobre o seu alegado déficit democrático e/ou institucional. A razão destes déficits é, freqüentemente, apontada como uma conseqüência da escassa accountability e da falta de transparência dos sistemas de decisão em nível regional. Os diferentes blocos regionais têm tentado responder a um ou ambos dos déficits em causa, mediante uma variedade de métodos e opções institucionais. A mais visível das fórmulas aplicadas é a criação e fortalecimento de um Parlamento regional - ou seja, supranacional. Este artigo pretende analisar, comparativamente, cinco Parlamentos regionais na Europa e na América Latina - o Parlamento Europeu, o Parlamento Latino-Americano, o Parlamento Centro-Americano, o Parlamento Andino e a Comissão Parlamentar Conjunta do Mercosul - com o objetivo de compreender o impacto que estas instituições têm tido no âmbito da representação regional, dos processos de decisão e do fortalecimento da accountability. As conclusões sugerem cinco fatores que os autores consideram pertinentes para a explicação das diferenças verificadas entre as duas regiões transatlânticas.Virtually no process of regional integration has been safe from the criticism of allegedly suffering from either democratic deficit, institutional deficit or both. These deficits, the argument goes, are the consequence of scarce accountability and the lack of transparency in regional decision-making. Different regional blocs have attempted in a variety of ways to confront one or both of these deficits, the most visible of which is the creation and empowerment of a regional parliament. This paper presents a comparative analysis of five of these institutions in Europe and Latin America - i.e. the European Parliament, the Latin American Parliament, the Central American Parliament, the Andean Parliament, and the Joint Parliamentary Commission of Mercosur - with the aim of

  11. HPV16 oncogenes E6 or/and E7 may influence the methylation status of RASSFIA gene promoter region in cervical cancer cell line HT-3.

    Science.gov (United States)

    Yin, Fufen; Wang, Ning; Wang, Shanshan; Yu, Fengsheng; Sun, Xin; Yu, Xiao; Luo, Bing; Zhao, Chengquan; Wang, Yankui

    2017-04-01

    Both human papillomavirus (HPV) infection and the aberrant Ras associated domain family gene 1A (RASSF1A) promoter methylation status participate in the pathogenesis of cervical cancer. Some studies suggest that E6, and E7 are involved in the pathogenetic mechanisms of RASSF1A. We mainly explored a possible involvement of HPV16 oncogenes E6 or/and E7 in RASSF1A promoter methylation status and possible roles of RASSF1A gene methylation in cervical cancer. Bisulfite genomic sequencing (BGS) PCR combined with TA clone, methylation-specific PCR (MSP) were used to analyze methylation status of the RASSF1A gene promoter in HPV16/18-positive and HPV-negative cervical cancer cell lines; ectopically expressed HPV16 E6, E7 and E6/E7 cervical cancer cell lines; normal cervical and cervical cancer tissues. The mRNA and protein expression of RASSF1A was detected by RT-PCR and western blotting. Re-expression and downregulated promoter methylation status were detected in the ectopically expressed HPV16 E6 and E7 cervical cancer cell line HT-3. The methylation status and expression of RASSF1A could be downregulated or reactivated by 5-Aza-dc in HT-3 and C33A cells. Additionally, statistics showed significant hypermethylation of RASSF1A in cervical cancer samples compared to that in normal cervical samples (PE6 and/or E7 may be involved in aberrant methylation and expression of the RASSF1A gene. RASSF1A gene expression could be regulated by its promoter methylation status. Additionally, the false negativity of the HPV detection may contribute to the uncertain relationship between HPV infection and aberrant RASSF1A promoter methylation.

  12. Redescription of Eubothrium fragile (Rudolphi, 1802) and E. rugosum (Batsch, 1786) (Cestoda: Pseudophyllidea), parasites of fish in the Holarctic Region.

    Science.gov (United States)

    Kuchta, Roman; Hanzelová, Vladimíra; Shinn, Andy P; Poddubnaya, Larisa G; Scholz, Tomás

    2005-09-01

    Two fish cestodes, the little-known Eubothrium fragile (Rudolphi, 1802) and E. rugosum (Batsch, 1786), the type species of the genus Eubothrium Nybelin, 1922, are redescribed on the basis of new material from twaite shad, Alosa fallax (Lacépède, 1803), from England and burbot, Lota lota (Linnaeus, 1758), from Russia, respectively. The tapeworms are compared with two other species of the genus, E. crassum (Bloch, 1779) and E. salvelini (Schrank, 1790), common parasites of salmonid fish in the Holarctic. The most notable differential characters are the size and the shape of the scolex (smaller and oval in E. fragile), the shape of the apical disc (four or more indentations in E. crassum), the number and size of the testes (the largest and least numerous in E. rugosum), and the position and size of the vitelline follicles (almost entirely cortical in distribution in E. fragile and E. crassum versus largely medullary in E. rugosum and E. salvelini). A comparison of species has also shown the morphological similarity of the freshwater species (E. rugosum and E. salvelini) on one hand and those of marine origin, E. fragile and E. crassum, on the other, with the latter species occurring also in fresh waters. A key to the identification of the species studied is also provided.

  13. Toxicity and SidJ-Mediated Suppression of Toxicity Require Distinct Regions in the SidE Family of Legionella pneumophila Effectors.

    Science.gov (United States)

    Havey, James C; Roy, Craig R

    2015-09-01

    Intracellular bacteria use a variety of strategies to evade degradation and create a replicative niche. Legionella pneumophila is an intravacuolar pathogen that establishes a replicative niche through the secretion of more than 300 effector proteins. The function of most effectors remains to be determined. Toxicity in yeast has been used to identify functional domains and elucidate the biochemical function of effectors. A library of L. pneumophila effectors was screened using an expression plasmid that produces low levels of each protein. This screen identified the effector SdeA as a protein that confers a strong toxic phenotype that inhibits yeast replication. The toxicity of SdeA was suppressed in cells producing the effector SidJ. The effector SdeA is a member of the SidE family of L. pneumophila effector proteins. All SidE orthologs encoded by the Philadelphia isolate of Legionella pneumophila were toxic to yeast, and SidJ suppressed the toxicity of each. We identified a conserved central region in the SidE proteins that was sufficient to mediate yeast toxicity. Surprisingly, SidJ did not suppress toxicity when this central region was produced in yeast. We determined that the amino-terminal region of SidE was essential for SidJ-mediated suppression of toxicity. Thus, there is a genetic interaction that links the activity of SidJ and the amino-terminal region of SidE, which is required to modulate the toxic activity displayed by the central region of the SidE protein. This suggests a complex mechanism by which the L. pneumophila effector SidJ modulates the function of the SidE proteins after translocation into host cells.

  14. O Brasil frente ao conflito regional na América Central: oposição ao intervencionismo e apoio à solução negociada, justa, equilibrada e duradoura (1979-1996

    Directory of Open Access Journals (Sweden)

    Carlos Federico Domínguez Avila

    2003-06-01

    Full Text Available O artigo analisa alguns aspectos da percepção brasileira sobre o conflito regional imperante na América Central, entre 1979 e 1996. Na conclusão sugere-se que essa política fundamentou-se no que aqui se chama de a "tese brasileira" sobre a origem, a evolução e os possíveis mecanismos de resolução para o conflito regional.The article analyzes some aspects of the Brazilian perception about the regional conflict in Central America, between 1979 and 1996. The conclusion suggests that the foreign policy towards the conflict was based on the so-called "Brazilian thesis" about the origin, the evolution and the possible mechanisms of solution to the regional conflict.

  15. Reprogrammed CRISPR-Cas9 targeting the conserved regions of HPV6/11 E7 genes inhibits proliferation and induces apoptosis in E7-transformed keratinocytes

    Directory of Open Access Journals (Sweden)

    Yu-Chen Liu

    2016-01-01

    Full Text Available The persistence infection of low-risk type (type 6 or type 11 of human papillomavirus (HPV is the main cause of genital warts. Given the high rate of recurrence after treatment, the use of a new molecular agent is certain to be of value. The aim of this study was to achieve targeted inactivation of viral E 7 gene in keratinocytes using the reprogrammed clustered regularly interspaced short palindromic repeats (CRISPR/CRISPR-associated (Cas 9 system. To accomplish this, a universal CRISPR-Cas9 system for targeting both HPV6/11 E 7 genes was constructed by using a dual guide RNA vector. After transfection of the vector into E 7-transfromed keratinocytes, the expression level of E 7 protein was measured using western-blot analysis and the sequence of the E 7 gene was determined using Sanger sequencing. Cell proliferation was analyzed by CCK-8 assay, and cell apoptosis was evaluated by Hoechst 33258 staining, flow cytometry analysis and ELISA assay. The results indicated that both HPV6/11 E 7 genes can be inactivated by the single CRISPR-Cas9 system. Furthermore, silencing of E 7 led to inhibition of cell proliferation and induction of apoptosis in E 7-transfromed keratinocytes but not in normal keratinocytes. Our data suggested that the reprogrammed CRISPR-Cas9 system has the potential for the development of an adjuvant therapy for genital warts.

  16. Reprogrammed CRISPR-Cas9 targeting the conserved regions of HPV6/11 E7 genes inhibits proliferation and induces apoptosis in E7-transformed keratinocytes.

    Science.gov (United States)

    Liu, Yu-Chen; Cai, Zhi-Ming; Zhang, Xue-Jun

    2016-01-01

    The persistence infection of low-risk type (type 6 or type 11) of human papillomavirus (HPV) is the main cause of genital warts. Given the high rate of recurrence after treatment, the use of a new molecular agent is certain to be of value. The aim of this study was to achieve targeted inactivation of viral E 7 gene in keratinocytes using the reprogrammed clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system. To accomplish this, a universal CRISPR-Cas9 system for targeting both HPV6/11 E 7 genes was constructed by using a dual guide RNA vector. After transfection of the vector into E 7-transformed keratinocytes, the expression level of E 7 protein was measured using western-blot analysis and the sequence of the E 7 gene was determined using Sanger sequencing. Cell proliferation was analyzed by CCK-8 assay, and cell apoptosis was evaluated by Hoechst 33258 staining, flow cytometry analysis and ELISA assay. The results indicated that both HPV6/11 E 7 genes can be inactivated by the single CRISPR-Cas9 system. Furthermore, silencing of E 7 led to inhibition of cell proliferation and induction of apoptosis in E 7-transformed keratinocytes but not in normal keratinocytes. Our data suggested that the reprogrammed CRISPR-Cas9 system has the potential for the development of an adjuvant therapy for genital warts.

  17. Anestesia regional e trombocitopenia não pré-eclâmptica; hora de repensar o nível seguro de plaquetas

    OpenAIRE

    Motoshi Tanaka; Mrinalini Balki; Anne McLeod; Jose C. A. Carvalho

    2009-01-01

    JUSTIFICATIVA E OBJETIVOS: Apesar de a anestesia regional ser amplamente utilizada no controle da dor em obstetrícia, seu uso pode não ser apropriado nas pacientes com trombocitopenia por causa do risco de hematoma no neuroeixo. Não existem fortes evidências sugerindo número mínimo de plaquetas necessário para garantir a segurança na realização da anestesia regional. O objetivo deste estudo foi rever a segurança da anestesia regional em pacientes com trombocitopenia não pré-eclâmptica na inst...

  18. Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults.

    Science.gov (United States)

    Foley, Jessica M; Salat, David H; Stricker, Nikki H; Zink, Tyler A; Grande, Laura J; McGlinchey, Regina E; Milberg, William P; Leritz, Elizabeth C

    2014-05-01

    Possession of the apolipoprotein E4 (APOE4) allele and diabetes risk are independently related to reduced white matter (WM) integrity that may contribute to the development of Alzheimer's disease (AD). The purpose of this study is to examine the interactive effects of APOE4 and diabetes risk on later myelinating WM regions among healthy elderly individuals at risk of AD. A sample of 107 healthy elderly (80 APOE4-/27 APOE4+) individuals underwent structural magnetic resonance imaging/diffusion tensor imaging (DTI). Data were prepared using Tract-Based Spatial Statistics, and a priori regions of interest (ROIs) were extracted from T1-based WM parcellations. Regions of interest included later myelinating frontal/temporal/parietal WM regions and control regions measured by fractional anisotropy (FA). There were no APOE group differences in DTI for any ROI. Within the APOE4 group, we found negative relationships between hemoglobin A1c/fasting glucose and APOE4 on FA for all later myelinating WM regions but not for early/middle myelinating control regions. Results also showed APOE4/diabetes risk interactions for WM underlying supramarginal, superior temporal, precuneus, superior parietal, and superior frontal regions. Results suggest interactive effects of APOE4 and diabetes risk on later myelinating WM regions, which supports preclinical detection of AD among this particularly susceptible subgroup.

  19. Polarization effects in the reaction e{sup +} + e{sup -} {yields} {rho}{sup +} + {rho}{sup -} and determination of the {rho}{sup -} meson form factors in the time-like region

    Energy Technology Data Exchange (ETDEWEB)

    Adamuscin, C. [Slovak Academy of Sciences, Dept. of Theoretical Physics, Bratislava (Slovakia); Gakh, G.I. [NSC Kharkov Physical Technical Institute, Kharkov (Ukraine); Tomasi-Gustafsson, E. [CEA Saclay, Dept. d' Astrophysique, de Physique des Particules, de Physique Nucleaire et de l' Instrumentation Associee (DAPNIA/SPhN), 91- Gif sur Yvette (France)

    2006-12-15

    The electron positron annihilation reaction into 4 pion production has been studied, through the channel e{sup +} + e{sup -} {yields} {rho}-bar + {rho}. The differential (and total) cross sections and various polarization observables for this reaction have been calculated in terms of the electromagnetic form factors of the corresponding {gamma}{sup *}{rho}{rho} current. The elements of the spin-density matrix of the {rho}-meson were also calculated. Numerical estimations have been done, with the help of phenomenological form factors obtained in the space-like region of the momentum transfer squared and analytically extended to the time-like region. (authors)

  20. Increased therapeutic efficacy of the prostate-specific oncolytic adenovirus Ad[I/PPT-E1A] by reduction of the insulator size and introduction of the full-length E3 region.

    Science.gov (United States)

    Danielsson, A; Dzojic, H; Nilsson, B; Essand, M

    2008-04-01

    Conditionally replicating adenoviruses are developing as a complement to traditional cancer therapies. Ad[I/PPT-E1A] is an E1B/E3-deleted virus that replicates exclusively in prostate cells, since the expression of E1A is controlled by the recombinant 1.4 kb prostate-specific PPT promoter. The transcriptional integrity of PPT is maintained by the 3.0 kb mouse H19 insulator that was introduced directly upstream of the PPT sequence. In order to increase the cloning capacity to be able to reintroduce E3 sequences in the 35.7 kb Ad[I/PPT-E1A] genome, various shorter insulators were examined in a luciferase reporter gene assay. It was found that the 1.6 kb core H19 insulator (i) improves the activity of PPT, compared to the 3.0 kb full-length insulator, while still maintaining prostate cell specificity and releasing 1.4 kb of space for insertion of additional sequences. To improve the ability of the virus to efficiently lyse infected cells and persist in vivo, we inserted the adenovirus death protein (ADP) or the full-length adenovirus E3 region. The oncolytic activity of PPT-E1A-based viruses was studied using MTS, crystal violet and replication assays. The virus with the reintroduced full-length E3-region (Ad[i/PPT-E1A, E3]) showed the highest cytopathic effects in vitro. Furthermore, this virus suppressed the growth of aggressively growing prostate tumors in vivo. Therefore, we conclude that Ad[i/PPT-E1A, E3] is a prostate-specific oncolytic adenovirus with a high potential for treating localized prostate cancer.

  1. Beam-helicity associated electroproduction of real photons ep {yields} e{gamma}{pi}N in the {Delta}-resonance region

    Energy Technology Data Exchange (ETDEWEB)

    Airapetian, A. [Giessen Univ. (Germany). 2. Physikalisches Inst.; Michigan Univ., Ann Arbor, MI (United States). Randall Laboratory of Physics; Akopov, N. [Yerevan Physics Institute (Argentina); Aschenauer, E.C. [DESY Zeuthen (Germany)] [and others; Collaboration: HERMES Collaboration

    2013-10-15

    The beam-helicity asymmetry in associated electroproduction of real photons, ep {yields} e{gamma}{pi}N, in the {Delta}(1232)-resonance region is measured using the longitudinally polarized HERA positron beam and an unpolarized hydrogen target. Azimuthal Fourier amplitudes of this asymmetry are extracted separately for two channels, ep {yields} e{gamma}{pi}{sup 0}p and ep {yields} e{gamma}{pi}{sup +}n, from a data set collected with a recoil detector. All asymmetry amplitudes are found to be consistent with zero.

  2. O sertanejo além-mar : identidade regional e imigração goiana na República da Irlanda

    OpenAIRE

    Reijane Pinheiro da Silva

    2011-01-01

    A partir da análise de um fluxo emigratório de brasileiros de Goiás em direção à República da Irlanda, esta tese tem como objetivo compreender como os elementos da identidade regional desses imigrantes são reforçados, negociados ou negados no contexto da vida no exterior. Procurei, ainda, entender como essa experiência impacta as leituras que esses sujeitos fazem do lugar ao qual pertencem e dos lugares pelos quais transitam. A etnografia e a coleta de dados foram realizadas no Brasil e na Ir...

  3. Beam-Recoil Polarization Transfer in the Nucleon Resonance Region in the Exclusive $\\vec{e}p \\to e'K^+\\vec{\\Lambda}$ and $\\vec{e}p \\to e'K^+\\vec{\\Sigma}^0$ Reactions at CLAS

    Energy Technology Data Exchange (ETDEWEB)

    D.S. Carman, B.A. Raue, for the CLAS Collaboration

    2009-06-01

    Beam-recoil transferred polarizations for the exclusive $\\vec{e}p \\to e'K^+ \\vec{\\Lambda},\\vec{\\Sigma}^0$ reactions have been measured using the CLAS spectrometer at Jefferson Laboratory. New measurements have been completed at beam energies of 4.261 and 5.754~GeV that span a range of momentum transfer $Q^2$ from 0.7 to 5.4~GeV$^2$, invariant energy $W$ from 1.6 to 2.6~GeV, and the full center-of-mass angular range of the $K^+$ meson. These new data add to the existing CLAS $K^+\\Lambda$ measurements at 2.567~GeV, and provide the first-ever data for the $K^+\\Sigma^0$ channel in electroproduction. Comparisons of the data with several theoretical models are used to study the sensitivity to $s$-channel resonance contributions and the underlying reaction mechanism. Interpretations within two semi-classical partonic models are made to probe the underlying reaction mechanism and the $s\\bar{s}$ quark-pair creation dynamics.

  4. Beam-Recoil Polarization Transfer in the Nucleon Resonance Region in the Exclusive $\\vec{e}p \\to e'K^+\\vec{\\Lambda}$ and $\\vec{e}p \\to e'K^+\\vec{\\Sigma}^0$ Reactions at CLAS

    CERN Document Server

    Carman, D S

    2009-01-01

    Beam-recoil transferred polarizations for the exclusive $\\vec{e}p \\to e'K^+ \\vec{\\Lambda},\\vec{\\Sigma}^0$ reactions have been measured using the CLAS spectrometer at Jefferson Laboratory. New measurements have been completed at beam energies of 4.261 and 5.754 GeV that span a range of momentum transfer $Q^2$ from 0.7 to 5.4 GeV$^2$, invariant energy $W$ from 1.6 to 2.6 GeV, and the full center-of-mass angular range of the $K^+$ meson. These new data add to the existing CLAS $K^+\\Lambda$ measurements at 2.567 GeV, and provide the first-ever data for the $K^+\\Sigma^0$ channel in electroproduction. Comparisons of the data with several theoretical models are used to study the sensitivity to s-channel resonance contributions and the underlying reaction mechanism. Interpretations within two semi-classical partonic models are made to probe the underlying reaction mechanism and the $s\\bar{s}$ quark-pair creation dynamics.

  5. INDUSTRIALIZAÇÃO E CAPITAL ESTATAL: UM ESTUDO DE DESENVOLVIMENTO REGIONAL EM SÃO JOSÉ DOS CAMPOS-SP

    Directory of Open Access Journals (Sweden)

    Marco Antonio Henrique

    2012-10-01

    Full Text Available O presente artigo discute a relação entre as políticas públicas e o consequente crescimento e desenvolvimento econômico regional. Desenvolvimento econômico tem um conceito mais amplo que crescimento uma vez que abrange não apenas o aumento da riqueza, mas também melhorias efetivas nos padrões de vida das pessoas de determinado lugar. Para tanto, utilizou-se de uma pesquisa bibliográfica e documental para fundamentar o aspecto básico da industrialização brasileira e as conseqüências na economia regional, sobretudo no que diz respeito à intervenção estatal e investimentos públicos localizados. Apresenta e discute políticas econômicas e seus impactos regionais: as decisões de investimentos baseados em incentivos fiscais, a fiscalização de tais políticas e os impactos dela decorrentes. O artigo aborda ainda (embora superficialmente a situação do país hoje, suas necessidades e perspectivas diante dos problemas atuais e sua inserção na economia internacional. O capital estatal como base econômica do município de São José dos Campos foi e continua sendo de fundamental importância, embora tenha trazido dependência da permanência das empresas pública na região.

  6. Daytime E-Region Irregularities During the 22 July 2009 Solar Eclipse over Chung-Li (24.9°N, 121.2°E, a Moderate Mid-Latitude Station

    Directory of Open Access Journals (Sweden)

    Potula Sree Brahmanandam

    2013-01-01

    Full Text Available The 22 July 2009 solar eclipse with an obscuration of > 83% at Chung-Li (24.9¢XN, 121.2¢XE, Dip 35¢XN in Taiwan during noon hours has provided a unique opportunity for us to examine its impact on E-region irregularities which were observed simultaneously by the 52 MHz coherent radar and a co-located ionosonde. Significant observations revealed that the daytime E-region strong backscatter echoes at multiple heights and a sudden intensification of the weak sporadic E-layer during the 22 July 2009 solar eclipse. These results follow the research findings of Patra et al. (2009. As the incident solar radiation suddenly blocked by intruding Moon during solar eclipse events that would generally create night-like ionospheric conditions, it is surmised that the E-region irregularities were indeed induced by the eclipse associated effects. The induced effects resulted in faster recombination of molecular ions, generation of gravity waves and electric fields that could have created a conducive environment to excite plasma irregularities through a gradient-drift instability mechanism. The vertical shears of radar Doppler velocity and the peak radar backscatter at the node of Doppler velocity shear, as resolved by the coherent scatter radar with interferometer technique, were possibly due to the upward propagating gravity waves and wave-induced polarization electric fields. The present observational results should not only be highly useful to ascertain plausible mechanisms responsible for nighttime E-region irregularities, but also provided evidence that a solar eclipse could generate E-region plasma irregularities over temperate mid-latitudes for the first time.

  7. Self-focusing of a high current density ion beam extracted with concave electrodes in a low energy region around 150 eV

    Energy Technology Data Exchange (ETDEWEB)

    Hirano, Y., E-mail: y.hirano@aist.go.jp [Innovative Plasma Technologies Group, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki (Japan); Laboratory of Physics, College of Science and Technologies, Nihon University, Tokyo (Japan); Kiyama, S.; Koguchi, H. [Innovative Plasma Technologies Group, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki (Japan); Sakakita, H. [Innovative Plasma Technologies Group, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki (Japan); Department of Engineering Mechanics and Energy, University of Tsukuba, Ibaraki (Japan)

    2014-02-15

    Spontaneous self-focusing of ion beam with high current density (J{sub c} ∼ 2 mA/cm{sup 2}, I{sub b} ∼ 65 mA) in low energy region (∼150 eV) is observed in a hydrogen ion beam extracted from an ordinary bucket type ion source with three electrodes having concave shape (acceleration, deceleration, and grounded electrodes). The focusing appears abruptly in the beam energy region over ∼135–150 eV, and the J{sub c} jumps up from 0.7 to 2 mA/cm{sup 2}. Simultaneously a strong electron flow also appears in the beam region. The electron flow has almost the same current density. Probably these electrons compensate the ion space charge and suppress the beam divergence.

  8. Audiovisivi per línsegnamento e nuove tecnologie nelle classi 2.0 della regione Emilia-Romagna

    Directory of Open Access Journals (Sweden)

    Laura Corazza

    2015-01-01

    Full Text Available I bambini e i ragazzi nel nuovo millennio sono forse più avvezzi alla visione di un film o di una trasmissione televisiva che non alla lettura di un libro. Quello che è certo, è che sono sottoposti a un bombardamento mediatico senza precedenti grazie a canali televisivi specializzati nella produzione di programmi per l’infanzia e l’adolescenza, alla Rete Internet e ai dispositivi mobili di ultima generazione. E a scuola? Come cambia la didattica? Al laboratorio Mela abbiamo documentato con un video l’avvio della prima esperienza delle Cl@ssi 2.0 in Emilia-Romagna nelle scuole secondarie inferiori. Alla fine dei 3 anni di sperimentazione, durante i quali gli insegnanti hanno utilizzato LIM, computer in classe e Moodle per l’insegnamento a distanza, abbiamo invece cercato di capire, con un questionario, come e quanto vengano utilizzati i video per la didattica. Ne sono seguite alcune riflessioni.

  9. Geology Arc Export Layer From Coal Bearing Geology of the Gulf Coast Coal Region (gulf_geol_dd.e00)

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This dataset is a polygon vector coverage of coal bearing geologic units that occur in states which comprise the Gulf Coast Coal Assessment Region as defined by the...

  10. A opção claustral e a tradição gastronómica local e regional

    OpenAIRE

    Conde, Antónia Fialho

    2013-01-01

    A História do quotidiano e da cultura material, de que a História da alimentação e da doçaria são parte integrante, tornaram-se áreas de excelência nos domínios da História e do Património particularmente a partir do último quartel do século XX, sendo alvo de múltiplas abordagens.A nossa reflexão será baseada nos hábitos alimentares quotidianos no mosteiro cisterciense feminino de S. Bento de Cástris durante o período moderno, procurando também apreciar a importância da doçaria, sobretudo a p...

  11. Search for TeV emission from the region around PSR B1706-44 with the H.E.S.S. experiment

    CERN Document Server

    Aharonian, F; Aye, K M; Bazer-Bachi, A R; Beilicke, M; Benbow, W; Berge, D; Berghaus, P; Bernlöhr, K; Boisson, C; Bolz, O; Borgmeier, C; Braun, I; Breitling, F; Brown, A M; Bussons-Gordo, J; Chadwick, P M; Chounet, L M; Cornils, R; Costamante, L; Degrange, B; Djannati-Atai, A; O'Connor-Drury, L; Dubus, G; Ergin, T; Espigat, P; Feinstein, F; Fleury, P; Fontaine, G; Fuchs, Y; Funk, S; Gallant, Y A; Giebels, B; Gillessen, S; Goret, P; Hadjichristidis, C; Hauser, M; Heinzelmann, G; Henri, G; Hermann, G; Hinton, J A; Hofmann, W; Holleran, M; Horns, D; De Jager, O C; Jung, I; Khelifi, B; Komin, Nu; Konopelko, A; Latham, I J; Le Gallou, R; Lemiere, A; Lemoine, M; Leroy, N; Lohse, T; Marcowith, A; Masterson, C; McComb, T J L; De Naurois, Mathieu; Nolan, S J; Noutsos, A; Orford, K J; Osborne, J L; Ouchrif, M; Panter, M; Pelletier, G; Pita, S; Pühlhofer, G; Punch, M; Raubenheimer, B C; Raue, M; Raux, J; Rayner, S M; Redondo, I; Reimer, A; Reimer, O; Ripken, J; Rob, L; Rolland, L; Rowell, G; Sahakian, V V; Sauge, L; Schlenker, S; Schlickeiser, R; Schuster, C; Schwanke, U; Siewert, M; Sol, H; Steenkamp, R; Stegmann, C; Tavernet, J P; Terrier, R; Theoret, C G; Tluczykont, M; Vasileiadis, G; Venter, C; Vincent, P; Visser, B; Völk, H J; Wagner, S J

    2005-01-01

    The region around PSR B1706-44 has been observed with the H.E.S.S. imaging atmospheric Cherenkov telescopes in 2003. No evidence for gamma-ray emission in the TeV range was found at the pulsar position or at the radio arc which corresponds to the supernova remnant G 343.1-2.3. The 99% confidence level flux upper limit at the pulsar position is Ful(E > 350GeV) = 1.4e-12 /cm^2/s assuming a power law with photon index of 2.5 and Ful(E > 500GeV) = 1.3e-12 /cm^2/s without an assumption on the spectral shape. The reported upper limits correspond to 8% of the flux from an earlier detection by the CANGAROO experiment.

  12. Phylogenetic relationships in Solanaceae and related species based on cpDNA sequence from plastid trnE-trnT region

    Directory of Open Access Journals (Sweden)

    Danila Montewka Melotto-Passarin

    2008-01-01

    Full Text Available Intergenic spacers of chloroplast DNA (cpDNA are very useful in phylogenetic and population genetic studiesof plant species, to study their potential integration in phylogenetic analysis. The non-coding trnE-trnT intergenic spacer ofcpDNA was analyzed to assess the nucleotide sequence polymorphism of 16 Solanaceae species and to estimate its ability tocontribute to the resolution of phylogenetic studies of this group. Multiple alignments of DNA sequences of trnE-trnT intergenicspacer made the identification of nucleotide variability in this region possible and the phylogeny was estimated by maximumparsimony and rooted with Convolvulaceae Ipomoea batatas, the most closely related family. Besides, this intergenic spacerwas tested for the phylogenetic ability to differentiate taxonomic levels. For this purpose, species from four other families wereanalyzed and compared with Solanaceae species. Results confirmed polymorphism in the trnE-trnT region at different taxonomiclevels.

  13. Regional power supply in 1998-1999. Progress report of the association of regional utilities - Arbeitsgemeinschaft regionaler Energieversorgungs-Unternehmen - ARE e.V.; Regionale Energieversorgung 1998-1999. Taetigkeitsbericht der Arbeitsgemeinschaft regionaler Energieversorgungs-Unternehmen - ARE - e.V.

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-04-01

    The ARE progress report discusses the following issues: Economic development and its effects on power supply; Deregulation of the electricity and gas market; Competition between regional utilities; Energy policy of the new German government; European regulations; Legislation on energy supply; Energy supply and cartel law; Regional supply in the East German states. [German] Der Taetigkeitsbericht der ARE befasst sich mit folgenden Themen: Gesamtwirtschaftliche Entwicklung und ihre Auswirkung auf die Energiewirtschaft, Oeffnung des Monopoles fuer Strom und Gas, Wettbewerb der regionalen Energieversorger, Energiepolitik der neuen Bundesregierung, Europaeische Richtlininen, energiewirtschaftsrecht, Versorgungswirtschaft und Kartellrecht und der Regionalversorgung in den neuen Bundeslaendern.

  14. Study of polarized-e polarized-p --> e-prime p pi0 in the Delta(1232) mass region using polarization asymmetries

    CERN Document Server

    Biselli, A; Amaryan, M J; Anciant, E; Anghinolfi, M; Asavapibhop, B; Asryan, G; Audit, G; Auger, T; Avakian, H; Barrow, S; Battaglieri, M; Beard, K; Bektasoglu, M; Bertozzi, W; Bianchi, N; Boiarinov, S; Bonner, B E; Bosted, P; Bouchigny, S; Bradford, R; Branford, D; Brooks, W K; Bültmann, S; Burkert, V D; Calarco, J R; Carman, D S; Carnahan, B; Cetina, C; Ciciani, L; Cole, P L; Coleman, A; Connelly, J; Cords, D; Corvisiero, P; Crabb, D; Crannell, H; Cummings, J; De Sanctis, E; De Vita, R; Degtyarenko, P V; Demirchyan, R A; Denizli, H; Dennis, L C; Dharmawardane, K V; Dhuga, K S; Djalali, C; Dodge, G E; Domingo, John J; Doughty, D C; Dragovitsch, P; Dugger, M; Dytman, S; Eckhause, M; Efremenko, Yu V; Egiyan, H; Egiyan, K S; Elouadrhiri, L; Empl, A; Eugenio, P; Farhi, L; Fatemi, R; Feuerbach, R J; Ficenec, J; Fissum, K; Forest, T A; Freyberger, A P; Frolov, V; Funsten, H; Gaff, S J; Gai, M; Gavalian, G; Gavrilov, V B; Gilad, S; Gilfoyle, G P; Giovanetti, K L; Girard, P; Golovatch, E; Griffioen, K A; Guidal, M; Guillo, M R; Guo, L; Gyurjyan, V; Hancock, D; Hardie, J; Heddle, D; Hersman, F W; Hicks, K; Hicks, R S; Holtrop, M; Hu, J; Hyde-Wright, C E; Ito, M M; Jenkins, D; Joo, K; Kelley, J H; Khandaker, M; Kim, K Y; Kim, K; Kim, W; Klein, A; Klein, F J; Klimenko, A V; Klusman, M; Kossov, M; Kramer, L H; Kuang, Y; Kühn, J; Kuhn, S E; Lachniet, J; Laget, J M; Lawrence, D; Leksin, G A; Longhi, A; Loukachine, K; Major, R W; Manak, J J; Marchand, C; Matthews, S K; McAleer, S; McNabb, J W C; McCarthy, J; Mecking, B A; Mestayer, M D; Meyer, C A; Minehart, R C; Mirazita, M; Miskimen, R; Mokeev, V; Muccifora, V; Müller, J; Murphy, L Y; Mutchler, G S; Napolitano, J; Nelson, S O; Niculescu, G; Niczyporuk, B B; Niyazov, R A; Nozar, M; O'Brien, J T; O'Rielly, G V; Ohandjanyan, M S; Osipenko, M; Park, K; Patois, Y; Peterson, G A; Philips, S; Pivnyuk, N; Pocanic, D; Pogorelko, O I; Polli, E; Preedom, B M; Price, J W; Qin, L M; Raue, B A; Riccardi, G; Ricco, G; Ripani, M; Ritchie, B G; Rock, S E; Ronchetti, F; Rossi, P; Rowntree, D; Rubin, P D; Sabourov, K; Salgado, C W; Sapunenko, V; Sargsyan, M; Schumacher, R A; Serov, V S; Sharabyan, Yu G; Shaw, J; Shuvalov, S M; Simionatto, S; Skabelin, A V; Smith, E S; Smith, L C; Smith, T; Sober, D I; Sorrell, L; Spraker, M; Stepanyan, S; Stoler, P; Strakovsky, I I; Taiuti, M; Taylor, S; Tedeschi, D J; Thoma, U; Thompson, R; Todor, L; Tung, T Y; Tur, C; Ungaro, M; Vineyard, M F; Vlassov, A; Wang, K; Weinstein, L B; Weller, H; Welsh, R; Weygand, D P; Whisnant, S; Witkowski, M; Wolin, E; Yegneswaran, A; Yun, J; Zhang, B; Zhao, J; Zhou, Z

    2003-01-01

    Measurements of the angular distributions of target and double spin asymmetries for the Delta(1232) in the exclusive channel (polarized-p polarized-e,e-prime p)pi0 obtained at Jefferson Lab in the Q2 range from 0.5 to 1.5 gev2 are presented. Results of the asymmetries are compared with the unitary isobar model, dynamical models, and the effective Lagrangian theory. Sensitivity to the different models was observed, particularly in relation to the description of background terms on which the target asymmetry depends significantly.

  15. Disputas Comerciais na OMC e no Mercosul: Divergências entre Brasil e Argentina sob a Perspectiva da Integração Regional

    Directory of Open Access Journals (Sweden)

    Caio Peixoto Chain

    2014-01-01

    Full Text Available International trade presents itself as an important form of internationalization of production that influences the growing movement towards regional integration, occurred mainly from the 80s. In the same way that trade relations between countries can boost regional integration, trade disagreements between them can negatively impact this process. This study aimed to analyze trade disputes between Brazil and Argentina triggered through the WTO; these disputes relate to the Dispute Settlement System of Mercosur when driven simultaneously, and verify the impact on Mercosur. Three cases were collected through literature: In the textile sector, agribusiness and petrochemicals. The research concluded that trade disputes between Brazil and Argentina were influenced by private companies that felt in disadvantage towards the bilateral trade agreements. However, for a dispute to be interna - tionally conducted, there is agreement by the national government is there some kind of violation in the international trade law. These situations tend to generate political consequences, usually negative, between the complainant and the respondent country that affect the process of regional integration.

  16. IMPACTOS TERRITORIAIS DOS PROGRAMAS ESTADUAIS DE INTERVENÇÃO REGIONAL NO CENTRO-OESTE: NE e N Goiano e entorno do Distrito Federal (1998-2006

    Directory of Open Access Journals (Sweden)

    Tadeu Alencar Arrais

    2010-01-01

    Full Text Available El presente artículo presenta resultados de proyecto de pesquisa en la línea de desarollo regional, con foco en la análisis de los impactos de los Planos Plurianuales en la estructura regional del territorio de Goiás. La análisis fue centrada en los impactos de los dos primeros Planos Plurianuales - Goiás para el siglo 21- PPA 2000/2003 y el Goiás para el siglo 21 - avanzar más - PPA 2004/2007 -en las regiones Norte de Goiás, Nordeste de Goiás y Entorno del Distrito Federal. Los resultados apuntan para la necesidad de maduración de las práticas de gestión, especialmente en relación al grado de participación de los gobiernos municipales, y para la necesidad de inversiones en infraestructura, especialmente estrutuctura urbana básica y estradas, demanda apuntada precisamente por los agentes municipales.

  17. Grau de cobertura dos planos de saúde e distribuição regional do gasto público em saúde Level of private health insurance coverage and regional distribution of public health expenditure

    Directory of Open Access Journals (Sweden)

    Samuel Kilsztajn

    2001-12-01

    Full Text Available O artigo analisa o grau de cobertura dos planos de saúde segundo as classes de rendimento mensal familiar e por unidade da federação e a distribuição dos recursos da Rede-SUS e do gasto público total em saúde por usuário dos serviços públicos de saúde nas regiões Norte-Nordeste e Centro-Sul do país. São apresentados e discutidos também os indicadores do gasto público total em saúde como percentual do PIB gerado nas regiões.This paper analyses the level of private health insurance coverage by classes of income and by states in Brazil and the distribution of the total public health expenditure by public health users in the North-Northeast and Central-South regions of the country. The paper also presents and discusses the total public health expenditure as a percentage of regional GDP.

  18. Study of the process e+e- -> omega pi0 in the phi-meson mass region with the KLOE detector

    CERN Document Server

    Ambrosino, F; Antonelli, M; Archilli, F; Beltrame, P; Bencivenni, G; Bertolucci, S; Bini, C; Bloise, C; Bocchetta, S; Bossi, F; Branchini, P; Campana, P; Capon, G; Capussela, T; Ceradini, F; Ciambrone, P; Crucianelli, F; De Lucia, E; de Santis, A; De Simone, P; De Zori, G; Denig, A; Di Domenico, A; Di Donato, C; Di Micco, B; Dreucci, M; Felici, G; Ferrer, M L; Fiore, S; Franzini, P; Gatti, C; Gauzzi, P; Giovannella, S; Graziani, E; Kluge, W; Lanfranchi, G; Lee-Franzini, J; Leone, D; Martini, M; Massarotti, P; Meola, S; Miscetti, S; Moulson, M; Müller, S; Murtas, F; Napolitano, M; Nguyen, F; Palutan, M; Pasqualucci, E; Passeri, A; Patera, V; Perfetto, F; Santangelo, P; Sciascia, B; Sciubba, A; Sibidanov, A; Spadaro, T; Testa, M; Tortora, L; Valente, P; Venanzoni, G; Versaci, R; Xu, G

    2008-01-01

    We have studied the e+e- -> omegapi0 cross section in the sqrt(s) interval 1000-1030 MeV using the pi+pi-pi0pi0 and pi0pi0gamma final states with a sample of ~600 pb^-1 collected with the KLOE detector at DAFNE. By fitting the observed interference pattern around M_phi for both final states, we extract the ratio of the decay widths Gamma(omega->pi0gamma)/Gamma(omega->pi+pi-pi0) = 0.0897 +- 0.0016 and derive the branching fractions BR(omega -> pi+pi-pi0)= (90.24 +- 0.19)%, BR(omega -> pi0gamma) = (8.09 +- 0.14)%. The parameters describing the e+e- -> omegapi0 reaction around M_\\phi are also used to extract the branching fraction for the OZI and G-parity violating phi -> omegapi0 decay: BR(phi->omegapi0) = (4.4 +- 0.6)x10^-5.

  19. Struttura produttiva e sviluppo regionale di lungo periodo in Italia (Production Structure and Long-Run Regional Development in Italy

    Directory of Open Access Journals (Sweden)

    Giulio Caianelli

    2012-04-01

    Full Text Available During the 1990s the link between specialisation and/or variety of the production structure and long-run local development has been widely studied both at theoretical and empirical level. Following this research line, the aim of this paper is twofold. First of all, we analyse, by means of transition matrices, the evolution of the model of specialisation/variety of manufacturing industries at regional level in Italy during the twentieth century. Secondly, we investigate, from an econometric point of view, the potential impact of specialisation and/or of variety on the different growth rates of manufacturing employment of the Italian regions during the period 1927-91. In order to carry out this kind of empirical investigation, we have built up a new and original historical data set which, using statistical information drawn from the Italian Industrial Census carried out from 1911 to 1991, provides data on the number of employees for 15 manufacturing industries and for 18 regions.           JEL Codes: R12, L60, R11, R23Keywords: Manufacturing, Regional Development, Regional

  20. A INDICAÇÃO GEOGRÁFICA COMO PROMOTORA DO DESENVOLVIMENTO LOCAL E REGIONAL: O CASO (EM POTENCIAL DO BORDADO DO SERIDÓ

    Directory of Open Access Journals (Sweden)

    Cínthia Kaline Vieira Silva

    2016-03-01

    Full Text Available Esse trabalho busca mostrar como surgiram as indicações geográficas, demonstrando seu potencial como ferramenta para o desenvolvimento regional e local, a partir do empoderamento das populações a partir das liberdades individuais. Com um grande potencial de promoção do desenvolvimento de produtos e processos frutos de um patrimônio cultural e conhecimentos tradicional das localidades, a Indicação Geográfica – IG – é um das formas, previstas na Lei de Propriedade Industrial Brasileira, de proteção dos produtos imateriais e dos princípios do mercado. Estabelecido seu potencial desenvolvimentista, demonstra-se, por meio de um estudo de caso de uma Indicação Geográfica em Potencial, no Seridó do Rio Grande do Norte, como a produção local dos Bordados, possibilita o desenvolvimento sócio econômico local e regional, e de que forma a concessão da IG potencializaria esse processo desenvolvimentista.

  1. Distribuição regional e socioeconômica da disponibilidade domiciliar de alimentos no Brasil em 2008-2009

    Directory of Open Access Journals (Sweden)

    Renata Bertazzi Levy

    2012-02-01

    Full Text Available OBJETIVO: Descrever a distribuição regional e socioeconômica da disponibilidade domiciliar de alimentos no Brasil. MÉTODOS: Estudo com dados secundários da Pesquisa de Orçamentos Familiares 2008-2009, realizada pelo Instituto Brasileiro de Geografia e Estatística sobre aquisições de alimentos e bebidas para consumo domiciliar. As quantidades de alimentos, registradas durante sete dias consecutivos nos 55.970 domicílios brasileiros amostrados, foram transformadas em calorias e nutrientes. Indicadores de qualidade da dieta foram construídos e analisados segundo estratos socioeconômicos e regionais da população brasileira. RESULTADOS: O teor protéico da disponibilidade alimentar mostrou-se adequado em todos os estratos regionais e econômicos. Em contrapartida, observou-se excesso de açúcares livres e de gorduras em todas as regiões, especialmente nas regiões Sul e Sudeste. A proporção de gorduras saturadas foi elevada no meio urbano e consistente com a maior participação de produtos de origem animal. A presença insuficiente de frutas, legumes e verduras foi comum em todas as regiões. Intensificação do teor de gorduras e diminuição do teor de carboidratos da dieta foram observadas com o aumento da renda. CONCLUSÕES: As características negativas da qualidade da dieta da população brasileira observadas ao final da primeira década do século XXI conferem alta prioridade para políticas públicas de promoção da alimentação saudável.

  2. Nova técnica: operação de Norwood com perfusão regional cerebral e coronariana New technique: Norwood operation with regional cerebral and coronary perfusion

    Directory of Open Access Journals (Sweden)

    Gláucio Furlanetto

    2009-12-01

    Full Text Available OBJETIVO: Avaliar o resultado imediato da operação de Norwood modificado com nova técnica de perfusão regional cerebral (PRCeA anterógrada associado a perfusão regional coronariana (PRCoR retrógrada em substituição à parada circulatória total com hipotermia profunda em crianças portadoras da Síndrome da Hipoplasia do Coração Esquerdo (SHCE com aorta ascendente extremamente hipoplásica (AH. MÉTODOS: No período de dezembro de 2006 a fevereiro de 2008, a operação de Norwood modificado com tubo entre o ventrículo direito e as artérias pulmonares ou shunt tipo Sano foi realizada em oito crianças portadoras de SHCE e aorta ascendente com diâmetro inferior a 3 mm, (quatro do sexo masculino e quatro do sexo feminino com idade média de 9,2 dias (variando de 1 a 29 dias e peso médio de 3,3 kg (variando de 2,7 a 3,8 kg. Utilizada CEC e hipotermia a 25ºC com duas cânulas venosas e anastomose de um enxerto de politetrafluoretileno com a artéria inominada utilizado como linha arterial e para PRCeA. A PRCoR foi realizada por meio de um desvio na linha arterial e colocação de um cateter na aorta ascendente. Foram analisados o resultado cirúrgico imediato e a presença de alterações neurológicas nesse período. RESULTADOS: O resultado cirúrgico imediato revelou mortalidade de 25% e ausência de comprometimento neurológico ao exame clínico. CONCLUSÃO: A operação de Norwood modificado pode ser realizada com PRCeA e PRCoR em crianças com SHCE e AH com resultado cirúrgico imediato satisfatório e ausência de complicações neurológicas.OBJECTIVE: To assess the immediate result of the modified Norwood procedure with new technique of anterograde regional cerebral perfusion (ARCeP and retrograde regional coronary perfusion (RRCoP in substitution of profound hypothermia and circulatory arrest in children with hypoplastic left heart syndrome (HLHS with extremely hypoplastic ascending aorta (HA. METHODS: In the period of

  3. A computational approach identifies two regions of Hepatitis C Virus E1 protein as interacting domains involved in viral fusion process.

    Science.gov (United States)

    Bruni, Roberto; Costantino, Angela; Tritarelli, Elena; Marcantonio, Cinzia; Ciccozzi, Massimo; Rapicetta, Maria; El Sawaf, Gamal; Giuliani, Alessandro; Ciccaglione, Anna Rita

    2009-07-29

    The E1 protein of Hepatitis C Virus (HCV) can be dissected into two distinct hydrophobic regions: a central domain containing an hypothetical fusion peptide (FP), and a C-terminal domain (CT) comprising two segments, a pre-anchor and a trans-membrane (TM) region. In the currently accepted model of the viral fusion process, the FP and the TM regions are considered to be closely juxtaposed in the post-fusion structure and their physical interaction cannot be excluded. In the present study, we took advantage of the natural sequence variability present among HCV strains to test, by purely sequence-based computational tools, the hypothesis that in this virus the fusion process involves the physical interaction of the FP and CT regions of E1. Two computational approaches were applied. The first one is based on the co-evolution paradigm of interacting peptides and consequently on the correlation between the distance matrices generated by the sequence alignment method applied to FP and CT primary structures, respectively. In spite of the relatively low random genetic drift between genotypes, co-evolution analysis of sequences from five HCV genotypes revealed a greater correlation between the FP and CT domains than respect to a control HCV sequence from Core protein, so giving a clear, albeit still inconclusive, support to the physical interaction hypothesis.The second approach relies upon a non-linear signal analysis method widely used in protein science called Recurrence Quantification Analysis (RQA). This method allows for a direct comparison of domains for the presence of common hydrophobicity patterns, on which the physical interaction is based upon. RQA greatly strengthened the reliability of the hypothesis by the scoring of a lot of cross-recurrences between FP and CT peptides hydrophobicity patterning largely outnumbering chance expectations and pointing to putative interaction sites. Intriguingly, mutations in the CT region of E1, reducing the fusion process in

  4. Diseño e implementación de un laboratorio de energía fotovoltaica para ITCA-FEPADE Centro Regional San Miguel

    OpenAIRE

    Fuentes Palacios, René Estanislao

    2015-01-01

    El presente documento contiene información concerniente al proyecto de investigación realizado por docentes en colaboración con los estudiantes de la carrera de Técnico en Ingeniería Eléctrica del Centro Regional de San Miguel, denominado “Diseño e implementación de un laboratorio de energía fotovoltaica para ITCA-FEPADE Centro Regional San Miguel”. El objetivo principal era diseñar y construir un laboratorio para que los estudiantes y docentes puedan desarrollar las prácticas de la asignatur...

  5. Staff Development in State Agencies Serving the Developmentally Disabled: An H.E.W. Region V Survey.

    Science.gov (United States)

    Michigan Univ., Ann Arbor. Inst. for the Study of Mental Retardation.

    A summary of data on inservice training programs for state agencies providing services to the developmentally disabled in Ohio, Wisconsin, Michigan, Indiana, Illinois, and Minnesota (Health, Education, and Welfare Region V) is provided. After a brief description of the purpose and methodology of the survey, the findings are presented. Among…

  6. Incentivi fiscali e politiche di sviluppo economico regionale in Europa (Fiscal Incentives and Regional Economics Development Policies in Europe

    Directory of Open Access Journals (Sweden)

    Beniamino Moro

    2001-09-01

    Full Text Available The paper shows that fiscal policy and tax incentives are more effective than monetary policy and monetary incentives in supporting a regional development policy among European regions. Anyway, only recently the EU Commission agreed that member countries can use tax incentives instead of monetary ones to support new investment in European less developed areas, but she still does not permit that a member state can apply a differentiated fiscal policy on a regional basis. In fact, according to the Commission, a reduced tax rate for growth purposes in European less developed areas has the same effect as a working aid for those firms located in these areas, which is forbidden by the Code of conduct that regulates fiscal competition among member states. The paper shows this interpretation is not correct and also demonstrates that a regional fiscal policy differentiated among areas inside the same member state can be supported without violate the sound principles of fiscal free competition incorporated in the Code of Conduct.

  7. Improvement of the complex mechanism of state administration of E-government process on the regional level

    Directory of Open Access Journals (Sweden)

    K. G. Kondakov

    2017-03-01

    Suggested structure of the Department will contribute to the improvement of administrative relations between national and regional administration levels. According to the offered structure, main tasks of the structural sub-divisions in the above-mentioned Department have also been defined.

  8. Regional Educational Assessment Diagnostic Services: Concept to Action (R.E.A.D.S.). Practicum Report. Maxi I.

    Science.gov (United States)

    Drew, Herbert A., Jr.; Lynch, Edward J.

    Described is the development of the Regional Education Assessment Diagnostic Services (READS) project, a collaborative organization of 20 Massachusetts school districts which would enable the districts to provide the diagnostic services mandated by recent state legislation for children having special needs. Among topics covered are the legislative…

  9. DIVERSIDADE TERRITORIAL E TRANSFERÊNCIAS CONSTITUCIONAIS PARA OS MUNICÍPIOS: CONSIDERAÇÕES SOBRE A ECONOMIA REGIONAL GOIANA

    Directory of Open Access Journals (Sweden)

    Tadeu Alencar Arrais

    2008-12-01

    Full Text Available O objetivo central desse artigo é discutir a diversidade territorial goiana a partir das transferências constitucionais para os municípios. As transferências constitucionais, dentre as quais o FPM, o FUNDEB e o ICMS, constituem a maior parcela de recursos destinados aos governos municipais. Cada um desses repasses tem relação direta com a dinâmica demográfica e econômica dos municípios. Para discutir as relações entre os repasses federais e estaduais para os municípios goianos, optamos por trabalhar na escala microrregional. Com esse artigo pretendemos contribuir com a discussão de um tema pouco abordado pela geografia, mas que tem importância impar na construção de políticas governamentais na escala municipal e regional

  10. Desenvolvimento regional e meio ambiente: desafios para a construção da região metropolitana de Bogotá (Colômbia)

    OpenAIRE

    Beltran, Jair Preciado [UNESP

    2012-01-01

    A cidade de Bogotá e seu território regional vêm experimentando um crescimento físico e demográfico desde o início da década de 1980 que determina diretamente o surgimento de fenômenos sociais e eventos ambientais extremamente complexos. A formação de Bogotá, como uma cidade importante no contexto nacional, desde meados do século passado, evidenciou uma maior procura de habitação, serviços públicos, infra-estrutura, serviços comunitários, o emprego e o bem-estar público. Nesse sentido, os mun...

  11. SU-E-J-272: Auto-Segmentation of Regions with Differentiating CT Numbers for Treatment Response Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Yang, C; Noid, G; Dalah, E; Paulson, E; Li, X [Medical College of Wisconsin, Milwaukee, WI (United States); Gilat-Schmidt, T [Marquette University, Milwaukee, WI (United States)

    2015-06-15

    Purpose: It has been reported recently that the change of CT number (CTN) during and after radiation therapy (RT) may be used to assess RT response. The purpose of this work is to develop a tool to automatically segment the regions with differentiating CTN and/or with change of CTN in a series of CTs. Methods: A software tool was developed to identify regions with differentiating CTN using K-mean Cluster of CT numbers and to automatically delineate these regions using convex hull enclosing method. Pre- and Post-RT CT, PET, or MRI images acquired for sample lung and pancreatic cancer cases were used to test the software tool. K-mean cluster of CT numbers within the gross tumor volumes (GTVs) delineated based on PET SUV (standard uptake value of fludeoxyglucose) and/or MRI ADC (apparent diffusion coefficient) map was analyzed. The cluster centers with higher value were considered as active tumor volumes (ATV). The convex hull contours enclosing preset clusters were used to delineate these ATVs with color washed displays. The CTN defined ATVs were compared with the SUV- or ADC-defined ATVs. Results: CTN stability of the CT scanner used to acquire the CTs in this work is less than 1.5 Hounsfield Unit (HU) variation annually. K-mean cluster centers in the GTV have difference of ∼20 HU, much larger than variation due to CTN stability, for the lung cancer cases studied. The dice coefficient between the ATVs delineated based on convex hull enclosure of high CTN centers and the PET defined GTVs based on SUV cutoff value of 2.5 was 90(±5)%. Conclusion: A software tool was developed using K-mean cluster and convex hull contour to automatically segment high CTN regions which may not be identifiable using a simple threshold method. These CTN regions were reasonably overlapped with the PET or MRI defined GTVs.

  12. Acordos bilaterais de comércio como estratégia de inserção regional e internacional do Chile Bilateral trade agreements as Chile's strategy for regional and international insertion

    Directory of Open Access Journals (Sweden)

    Renata Rossetto Lopes

    2010-12-01

    Full Text Available O trabalho analisa a mudança na estratégia de inserção regional e internacional do Chile no começo dos anos 1990, com ênfase em acordos comerciais bilaterais, depois de ter praticado a abertura comercial generalizada desde meados da década de 1970. A opção por acordos bilaterais foi adotada pelo primeiro governo democrático, como parte da orientação de manter e aprofundar a abertura externa empreendida pela ditadura, e conseguiu ampliar as vendas externas e diversificar produtos e destinos. As exportações têm papel decisivo na economia chilena, aberta e pequena, e os 24 acordos bilaterais de comércio com diferentes países e regiões, além de outros em negociação, podem ser explicados pelo esgotamento das possibilidades de ampliar o comércio por meio de reduções adicionais da tarifa externa unilateral, hoje em 6% para quase todos os produtos. A formação de uma rede de acordos bilaterais ampla e diversificada, contudo, tem também interesses políticos, estratégicos e de segurança em relação a vizinhos e a países próximos, além de evitar que o Chile precise se integrar, como membro pleno, a blocos regionais para garantir seus interesses, o que amplia as possibilidades de lidar com diferentes e importantes parceiros no âmbito internacional.The paper analysis the change of Chile's regional and international strategy of insertion through bilateral trade agreements in the beginning of the 90s, after a generalized trade opening since the middle of the 70s. The bilateral trade agreements strategy was set up by the democratic governments as part of the direction of maintaining and deepening the unilateral trade liberalization undertaken by the dictatorship, enlarging exports and diversifying products and markets. Exports have a decisive role in Chile's economy, open and small. The 24 bilateral trade agreements already signed with different countries and regions (besides others under negotiation can be explained by the

  13. Época de nascimento sobre a composição regional e tecidual da carcaça de cordeiros da raça Texel Birth season on regional and tissue carcass composition in Texel breed lambs

    Directory of Open Access Journals (Sweden)

    Gilson de Mendonça

    2008-06-01

    Full Text Available Foram avaliados os efeitos de épocas alternativas de nascimento sobre a composição regional e tecidual da carcaça em ovinos. Quarenta e nove cordeiros machos não-castrados da raça Texel, nascidos em duas épocas (agosto e novembro, foram mantidos em regime de pastagem e abatidos com média de idade de 129 e 164 dias, respectivamente. Previamente aos abates foi feita a avaliação da produção forrageira do campo pelo método Botanal. Foram verificadas melhores condições forrageiras para os cordeiros nascidos em agosto, que apresentaram maior peso e proporção na maioria dos cortes, assim como menor proporção de músculo na paleta e perna; apresentando maior conteúdo de tecido adiposo na maioria dos cortes da carcaça. Para os cordeiros nascidos em novembro, ocorreu maior relação músculo:gordura e músculo:osso na paleta e na perna, assim como maior relação músculo:gordura no costilhar. As condições nutricionais são responsáveis pelas diferenças nos pesos e rendimentos dos cortes, assim como na composição tecidual da carcaça, em cordeiros mantidos em regime de pasto, viabilizando o uso de época alternativa de nascimentos para incrementar a oferta de animais para o abate.The effect of alternative birth season on regional and tissue carcass composition of sheep was evaluated. Forty nine (49 Texel intact male lambs, born in two seasons (August and November, were kept under grazing and slaughtered with an average age of 129 and 164 days, respectively. Prior to slaughter forage production was measured using Botanal method. Lambs born in August had more favorable forage conditions, showing higher body weight and proportion in the majority of cuts, as well as lower proportion of shoulder and leg muscles showing higher adipose tissue content in the majority of carcass cuts. For lambs born in November, a higher muscle:fat and muscle:bone rate in shoulder and leg, as well as a higher ribcut muscle:fat rate. Nutritional

  14. Genome-wide comparisons of phylogenetic similarities between partial genomic regions and the full-length genome in Hepatitis E virus genotyping.

    Directory of Open Access Journals (Sweden)

    Shuai Wang

    Full Text Available Besides the complete genome, different partial genomic sequences of Hepatitis E virus (HEV have been used in genotyping studies, making it difficult to compare the results based on them. No commonly agreed partial region for HEV genotyping has been determined. In this study, we used a statistical method to evaluate the phylogenetic performance of each partial genomic sequence from a genome wide, by comparisons of evolutionary distances between genomic regions and the full-length genomes of 101 HEV isolates to identify short genomic regions that can reproduce HEV genotype assignments based on full-length genomes. Several genomic regions, especially one genomic region at the 3'-terminal of the papain-like cysteine protease domain, were detected to have relatively high phylogenetic correlations with the full-length genome. Phylogenetic analyses confirmed the identical performances between these regions and the full-length genome in genotyping, in which the HEV isolates involved could be divided into reasonable genotypes. This analysis may be of value in developing a partial sequence-based consensus classification of HEV species.

  15. Satisfação no serviço público: um estudo na Superintendência Regional do Trabalho e Emprego no Ceará

    Directory of Open Access Journals (Sweden)

    Isac de Freitas Brandão

    Full Text Available A satisfação no trabalho é vista como um aspecto que, quando presente, motiva os empregados, e afeta positivamente a produtividade destes. Nesta perspectiva, o presente estudo buscou identificar os fatores preponderantes para satisfação no trabalho na Superintendência Regional do Trabalho e Emprego (SRTE/CE, à luz da teoria bifatorial de Herzberg (1997. Foi realizada uma survey com três grupos distintos de agentes públicos: auditores fiscais do trabalho, servidores administrativos e estagiários. Os dados foram analisados por meio de métodos quantitativos e análise de conteúdo. O questionário continha uma escala de satisfação tipo Likert de cinco pontos, versando sobre o nível de satisfação dos pesquisados, com cinco fatores motivacionais e seis fatores higiênicos, além de duas perguntas abertas sobre outros aspectos relativos à satisfação ou insatisfação dos respondentes com o trabalho. Os resultados revelaram que os fatores motivacionais que predominaram na geração da satisfação nos três grupos investigados foram a realização profissional, as atividades desempenhadas e a responsabilidade atribuída. Entre os fatores higiênicos, os servidores e estagiários do Ministério do Trabalho e Emprego mostraram-se mais satisfeitos, de forma geral, com a supervisão e com os relacionamentos interpessoais. Estes resultados corroboram pesquisas anteriores realizadas em outras entidades governamentais. Adicionalmente, análises de correlação e testes não paramétricos mostraram que as características do perfil do respondente podem influenciar na satisfação com alguns fatores motivacionais e higiênicos analisados.

  16. Angular analysis of the $B^0 \\to K^{*0} e^+ e^-$ decay in the low-$q^2$ region at LHCb

    CERN Multimedia

    Borsato, Martino

    2015-01-01

    An angular analysis of the $B^0 \\rightarrow K^{*0} e^+ e^-$ decay is performed using a data sample, corresponding to an integrated luminosity of 3.0${\\mbox {fb}^{-1}}$, collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of 7 and 8 TeV during 2011 and 2012. For the first time several observables are measured in the dielectron mass squared ($q^2$) interval between 0.002 and 1.120${\\mathrm{\\,Ge\\kern -0.1em V^2\\!/}c^4}$. The angular observables $F_{\\mathrm{L}}$ and $A_{\\mathrm{T}}^{\\mathrm{Re}}$ which are related to the \\Kstarz polarisation and to the lepton forward-backward asymmetry, are measured to be $F_{\\mathrm{L}}= 0.16 \\pm 0.06 \\pm0.03$ and $A_{\\mathrm{T}}^{\\mathrm{Re}} = 0.10 \\pm 0.18 \\pm 0.05$, where the first uncertainty is statistical and the second systematic. The angular observables $A_{\\mathrm{T}}^{(2)}$ and $A_{\\mathrm{T}}^{\\mathrm{Im}}$ which are sensitive to the photon polarisation in this $q^2$ range, are found to be $A_{\\mathrm{T}}^{(2)} = -0.23 \\pm 0.23 \\pm...

  17. Meaurement of the target single-spin asymmetry in quasi-elastic region from the reaction {sup 3}He{up_arrow}(e,e')

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yawei [Rutgers

    2013-10-01

    A measurement of the inclusive target single-spin asymmetry has been performed using the quasi-elastic {sup 3}He{up_arrow}(e,e') reaction with a vertically polarized {sup 3}He target at Q{sup 2} values of 0.13, 0.46 and 0.97 GeV{sup 2}. This asymmetry vanishes under the one photon exchange assumption. But the interference between two-photon exchange and one-photon exchange gives rise to an imaginary amplitude, so that a non-zero A{sub y} is allowed. The experiment, conducted in Hall A of Jefferson Laboratory in 2009, used two independent spectrometers to simultaneously measure the target single-spin asymmetry. Using the effective polarization approximation, the neutron single-spin asymmetries were extracted from the measured {sup 3}He asymmetries. The measurement is to establish a non-vanishing A{sub y}. Non-zero asymmetries were observed at all Q{sup 2} points, and the overall precision is an order of magnitude improved over the existing proton data. The data provide new constraints on Generalized Parton Distribution (GPD) models and new information on the dynamics of the two-photon exchange process.

  18. Efeitos de dopamina e noradrenalina no fluxo sangüíneo regional no tratamento do choque séptico Dopamine and noradrenaline effects in the blood flux regional on therapeutic in the septic shock

    Directory of Open Access Journals (Sweden)

    Milena Penteado Ferraro Miranda

    2008-03-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A noradrenalina e a dopamina são utilizadas, no estado de choque, com o intuito de oferecer suporte hemodinâmico e restabelecer a perfusão tecidual. As ações farmacológicas desses vasopressores podem ser variadas, deste modo, o uso necessita, por parte do clinico, interpretação dos efeitos hemodinâmicos, com observação das variáveis sistêmica e regional. O objetivo deste estudo foi analisar as publicações acerca dos efeitos da noradrenalina e dopamina em baixas doses na perfusão hepatoesplâncnica e renal no tratamento do choque séptico. MÉTODO: Foram selecionados artigos (n = 27 sobre o uso de noradrenalina e dopamina em choque séptico, publicados no período de 1997 a setembro de 2007 revisados na PubMed, base de dados da National Library of Medicine (NLM. Utilizou-se o recurso MESH com os descritores noradrenaline, dopamine e sepsis. RESULTADOS: Os efeitos de dopamina e noradrenalina na perfusão renal demonstraram ser semelhantes em relação ao aumento da diurese e não alteração na depuração de creatinina. A noradrenalina não afetou a perfusão tissular renal, apesar de elevar o tônus vascular. Quanto aos efeitos esplâncnicos, os dois fármacos demonstraram aumentar o fluxo sangüíneo, porém redistribuem o sangue nesse compartimento. CONCLUSÕES: Os estudos analisados foram controversos não demonstrando consenso acerca do fármaco mais oportuno para o restabelecimento hemodinâmico e manutenção de perfusão regional adequada.BACKGROUND AND OBJECTIVES: Norepinephrine and dopamine are used, in the state of shock, with the intention of offering hemodynamic support and to reestablish tissue perfusion. The pharmacological effects of these vasopressors can be diverse, for this reason, their use requires, through the clinician, an interpretation of the hemodynamic effects with observation of the systemic variations and region. With this in mind, the objective of this study was to analyze

  19. Tecnologia, especialização regional e produtividade: um estudo da pecuária leiteira em Minas Gerais

    Directory of Open Access Journals (Sweden)

    Mauro Borges Lemos

    2003-01-01

    Full Text Available Este trabalho pretende estabelecer um comparativo entre algumas microrregiões mineiras produtoras de leite, enfocando, sobretudo, características tecnológicas e de especialização. Trabalha-se com a idéia de que estas variáveis explicam em grande medida o diferencial de produção e produtividade do setor leiteiro, sendo importante o seu entendimento dentro do contexto de intensas mudanças as quais o setor vem passando nos últimos anos no Brasil. Desenvolvendo um estudo de dimensão espacial, pretende-se traçar um perfil da atividade em Minas Gerais, apontando os principais "gargalos" para o seu desenvolvimento e as perspectivas para a redução das desigualdades no setor.

  20. Determinantes espaciais e socioeconômicos do suicídio no Brasil: uma abordagem regional

    OpenAIRE

    Ludmilla R. C. Gonçalves; Eduardo Gonçalves; Lourival Batista de Oliveira Júnior,

    2011-01-01

    A Organização Mundial da Saúde avalia o suicídio como um problema de saúde pública, estando entre as dez causas mais frequentes de morte, além de ser a segunda ou terceira causa de morte entre 15 e 34 anos de idade. Estimativas mostram que para cada suicídio, existem pelo menos dez tentativas suficientemente sérias que exigem atenção médica e para cada tentativa de suicídio registrada, existem quatro não conhecidas. O objetivo desse artigo é avaliar os determinan...

  1. Regional energy supply in 1996/1997. Progress report of the working pool of regional power supply companies (ARE e.V.); Regionale Energieversorgung 1996-1997. Taetigkeitsbericht der Arbeitsgemeinschaft regionaler Energieversorgungs-Unternehmen - ARE - e.V

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    Generally speaking the present report deals with the regional power supply as part of the whole economy. In this connection it also addresses issues of economic development. The following topics are covered in its report on the activities of ARE since the annual meeting of 1996; energy policy, regional supply in the new Laender, European common market for electricity and natural gas, energy-economic law, special provisions under cartel law concerning public utilities. The report concludes with a description of the organisation of ARE (tasks and aims, members, executive board, management, committees, headquarters). (RHM) [Deutsch] Gegenstand des Berichtes ist zunaechst die regionale Energieversorgung im Rahmen der Gesamtwirtschaft. Dabei wird sowohl auf die wirtschaftliche Entwicklung als auf die regionale Energieversorgung eingegangen. Anschliessend wird ein Ueberblick ueber die Taetigkeit des ARE seit der Jahrestagung 1996 gegeben. Dabei werden Aktivitaeten in den Bereichen Energiepolitik, Regionalversorgung in den neuen Bundeslaendern, europaeischer Binnenmarkt fuer Elektrizitaet und Gas, Energiewirtschaftsrecht sowie kartellrechtlicher Ausnahmebereich Versorgungswirtschaft behandelt. Abschliessend wird die Organisation der ARE (Aufgaben und Ziele, Mitglieder, Vorstand, Geschaeftsfuehrung, Ausschuesse, Geschaeftsstelle) beschrieben. (RHM)

  2. ¿Mercosur o Alca? Clase dominante, gobierno e inserción regional en los inicios del Kirchnerismo

    Directory of Open Access Journals (Sweden)

    Julián Kan

    2013-10-01

    Full Text Available El objetivo de este trabajo es analizar la relación entre gobierno, corporaciones empresarias de la clase dominante y los proyectos MERCOSUR y ALCA en los inicios del gobierno de Kirchner. La hipótesis principal es que los cambios en la inserción regional de Argentina desde 2003 (reconstrucción del MERCOSUR y rechazo al ALCA, tuvieron entre una de sus causas a las acciones de corporaciones como la Unión Industrial Argentina (UIA y la Sociedad Rural Argentina (SRA. Como afirma Katz (2006 aquella reconfiguración regional, además de estar influenciada por las protestas sociales antineoliberales, también respondió a la demanda de una diferente inserción regional por parte de las clases dominantes locales. Mediante el análisis de la prensa escrita y de documentación de las corporaciones, observaremos los posicionamientos sobre el ALCA y el MERCOUSR, el tipo de intervención del gobierno que reclaman y por qué apoyan o rechazan las negociaciones entre 2003 y 2004, en la reunión de la Ronda Doha de Cancún de la Organización mundial de Comercio (OMC y en las Minicumbres del ALCA de Miami y Puebla, donde quedaron trabadas las negociaciones del ALCA y se produjo la reorientación del MERCOSUR

  3. Electromobility in metropolitan regions. The case study MINI E Berlin powered by Vattenfall; Elektromobilitaet in Metropolregionen. Die Feldstudie MINI E Berlin powered by Vattenfall

    Energy Technology Data Exchange (ETDEWEB)

    Krems, Josef F.; Weinmann, Oliver; Weber, Julian; Westermann, Dirk; Albayrak, Sahin (eds.)

    2013-04-01

    One promising option of the reduction of the emission of greenhouse gases and the promotion of the climate protection is the utilization of electric-powered vehicles. The customer acceptance and practical suitability of electric-powered vehicles are essential factors of success which are investigated within the Berlin field test 'MINI E 1.0 powered by Vattenfall' from the perspective of energy industry, vehicle manufacturer and the science. Beside the hurdles up to the establishment in the mass market, it is shown how the users with aspects specific for electric-powered vehicles interact, and how the controlled loading facilitates the optimal integration of wind power. The comprehensive collection of subjective and objective data as well as detailed information on the conception of the case study complete the contribution under consideration.

  4. Probing the extent of the non-thermal emission from the Vela X region at TeV energies with H.E.S.S

    CERN Document Server

    Abramowski, A; Aharonian, F; Akhperjanian, A G; Anton, G; Balenderan, S; Balzer, A; Barnacka, A; Becherini, Y; Tjus, J Becker; Bernlöhr, K; Birsin, E; Biteau, J; Bochow, A; Boisson, C; Bolmont, J; Bordas, P; Brucker, J; Brun, F; Brun, P; Bulik, T; Carrigan, S; Casanova, S; Cerruti, M; Chadwick, P M; Charbonnier, A; Chaves, R C G; Cheesebrough, A; Cologna, G; Conrad, J; Couturier, C; Dalton, M; Daniel, M K; Davids, I D; Degrange, B; Deil, C; deWilt, P; Dickinson, H J; Djannati-Ataï, A; Domainko, W; Drury, L O'C; Dubois, F; Dubus, G; Dutson, K; Dyks, J; Dyrda, M; Egberts, K; Eger, P; Espigat, P; Fallon, L; Farnier, C; Fegan, S; Feinstein, F; Fernandes, M V; Fernandez, D; Fiasson, A; Fontaine, G; Förster, A; ling, M Füß; Gajdus, M; Gallant, Y A; Garrigoux, T; Gast, H; Giebels, B; Glicenstein, J F; Glück, B; Göring, D; Grondin, M -H; Häffner, S; Hague, J D; Hahn, J; Hampf, D; Harris, J; Heinz, S; Heinzelmann, G; Henri, G; Hermann, G; Hillert, A; Hinton, J A; Hofmann, W; Hofverberg, P; Holler, M; Horns, D; Jacholkowska, A; Jahn, C; Jamrozy, M; Jung, I; Kastendieck, M A; ski, K Katarzyń; Katz, U; Kaufmann, S; Khélifi, B; Klochkov, D; niak, W Kluź; Kneiske, T; Komin, Nu; Kosack, K; Kossakowski, R; Krayzel, F; Krüger, P P; Laffon, H; Lamanna, G; Lenain, J -P; Lennarz, D; Lohse, T; Lopatin, A; Lu, C -C; Marandon, V; Marcowith, A; Masbou, J; Maurin, G; Maxted, N; Mayer, M; McCom, T J L; Medina, M C; Méhault, J; Menzler, U; Moderski, R; Mohamed, M; Moulin, E; Naumann, C L; Naumann-Godo, M; deNaurois, M; Nedbal, D; Nguyen, N; Niemiec, J; Nolan, S J; Ohm, S; aWilhelmi, E deOñ; Opitz, B; Ostrowski, M; Oya, I; Panter, M; Parsons, D; PazArribas, M; Pekeur, N W; Pelletier, G; Perez, J; Petrucci, P -O; Peyaud, B; Pita, S; Pühlhofer, G; Punch, M; Quirrenbach, A; Raue, M; Reimer, A; Reimer, O; Renaud, M; delosReyes, R; Rieger, F; Ripken, J; Rob, L; Rosier-Lees, S; Rowell, G; Rudak, B; Rulten, C B; Sahakian, V; Sanchez, D A; Santangelo, A; Schlickeiser, R; Schulz, A; Schwanke, U; Schwarzburg, S; Schwemmer, S; Sheidaei, F; Skilton, J L; Sol, H; Spengler, G; Stawarz, L; Steenkamp, R; Stegmann, C; Stinzing, F; Stycz, K; Sushch, I; Szostek, A; Tavernet, J -P; Terrier, R; Tluczykont, M; Trichard, C; Valerius, K; vanEldik, C; Vasileiadis, G; Venter, C; Viana, A; Vincent, P; Völk, H J; Volpe, F; Vorobiov, S; Vorster, M; Wagner, S J; Ward, M; White, R; Wierzcholska, A; Wouters, D; Zacharias, M; Zajczyk, A; Zdziarski, A A; Zech, A; Zechlin, H -S

    2012-01-01

    Vela X is a region of extended radio emission in the western part of the Vela constellation: one of the nearest pulsar wind nebulae (PWNe), and associated with the energetic Vela pulsar (PSR B0833-45). Extended very-high-energy (VHE) $\\gamma$-ray emission (HESS $\\mathrm{J0835\\mhyphen 455}$) was discovered using the H.E.S.S. experiment in 2004. The VHE $\\gamma$-ray emission was found to be coincident with a region of X-ray emission discovered with ${\\it ROSAT}$ above 1.5 keV (the so-called \\textit{Vela X cocoon}): a filamentary structure extending southwest from the pulsar to the centre of Vela X. A deeper observation of the entire Vela X nebula region, also including larger offsets from the cocoon, has been performed with H.E.S.S. This re-observation was carried out in order to probe the extent of the non-thermal emission from the Vela X region at TeV energies and to investigate its spectral properties. In order to increase the sensitivity to the faint $\\gamma$-ray emission from the very extended Vela X regio...

  5. Meteor radar measurements of MLT winds near the equatorial electro jet region over Thumba (8.5° N, 77° E: comparison with TIDI observations

    Directory of Open Access Journals (Sweden)

    S. R. John

    2011-07-01

    Full Text Available The All-Sky interferometric meteor (SKYiMET radar (MR derived winds in the vicinity of the equatorial electrojet (EEJ are discussed. As Thumba (8.5° N, 77° E; dip lat. 0.5° N is under the EEJ belt, there has been some debate on the reliability of the meteor radar derived winds near the EEJ height region. In this regard, the composite diurnal variations of zonal wind profiles in the mesosphere-lower thermosphere (MLT region derived from TIMED Doppler Interferometer (TIDI and ground based meteor radar at Thumba are compared. In this study, emphasis is given to verify the meteor radar observations at 98 km height region, especially during the EEJ peaking time (11:00 to 14:00 LT. The composite diurnal cycles of zonal winds over Thumba are constructed during four seasons of the year 2006 using TIDI and meteor radar observations, which showed good agreement especially during the peak EEJ hours, thus assuring the reliability of meteor radar measurements of neutral winds close to the EEJ height region. It is evident from the present study that on seasonal scales, the radar measurements are not biased by the EEJ. The day-time variations of HF radar measured E-region drifts at the EEJ region are also compared with MR measurements to show there are large differences between ionospheric drifts and MR measurements. The significance of the present study lies in validating the meteor radar technique over Thumba located at magnetic equator by comparing with other than the radio technique for the first time.

  6. Calibração regional e local da equação de Hargreaves para estimativa da evapotranspiração de referência Regional and local calibration of Hargreaves equation for estimating reference evapotranspiration

    Directory of Open Access Journals (Sweden)

    Diego Simões Fernandes

    2012-06-01

    Full Text Available A equação de Penman-Monteith FAO-56 (EToPM tem sido recomendada pela FAO, Organização para a Alimentação e Agricultura das Nações Unidas (ONU, como padrão para estimar a evapotranspiração de referência (ETo. Essa equação requer muitas variáveis que não estão disponíveis na maioria das estações meteorológicas no Brasil central. Por outro lado, a equação de Hargreaves é considerada simples e demanda somente dados de temperatura máxima e mínima para estimar a ETo. Entretanto, essa equação requer um ajuste local. Esse estudo analisa a possibilidade de utilizar a equação de Hargreaves ajustada para estimar a ETo no estado de Goiás. Para isso, os parâmetros empíricos, HC (coeficiente empírico de Hargreaves e HE (expoente empírico de Hargreaves, da equação de Hargreaves foram ajustados considerando dois processos, ajuste local (HGR - Hargreaves ajuste local e ajuste regional (HGL - Hargreaves ajuste regional. Para o HGL, os parâmetros empíricos foram ajustados para cada estação meteorológica. Já, para o HGR, os parâmetros empíricos foram ajustados considerando conjuntamente os dados de todas as estações meteorológicas. A equação de Hargreaves ajustada para ambos os processos, local e regional, apresentou valores de ERQM de 17,95 e 21,93%, respectivamente, considerando o conjunto total de dados climáticos. A equação de Hargreaves ajustada localmente ou regionalmente é uma opção para estimar os valores diários de ETo no Estado de Goiás em locais em que a disponibilidade de dados climáticos é limitada.The FAO-56 Penman-Monteith equation (EToPM has been recommended by the Food and Agriculture Organization (FAO of the United Nations as the standard equation for estimating reference evapotranspiration (ETo. The FAO-56 PM equation requires numerous weather data that are not available in most of the stations of Brazil central. On the other hand, the Hargreaves equation is a more simple equation for

  7. A prevalência de cárie e determinação do crescimento ponderal e corporal utilizando-se a dieta básica regional modificada - estudo em ratos

    OpenAIRE

    Paula Alves Figueiredo Lima, Ana

    2005-01-01

    Os objetivos da presente pesquisa foram determinar a prevalência de cárie em molares e o crescimento ponderal e corporal de ratos (Rattus norvegicus albinus Wistar), utilizando-se a Dieta Básica Regional Modificada incluindo elementos nutricionais da região, acrescida ou não de flúor. Foram utilizados 60 ratos, do sexo masculino, com 23 dias de idade. Estes animais foram divididos aleatoriamente em cinco grupos, os quais receberam, durante 120 dias, os seguintes tratamentos: gr...

  8. The Transverse Momentum and Total Cross Section of $e^{+}e^{-}$ Pairs in the Z-Boson Region from $p\\overline{p}$ collisions at s**(1/2) = 1.8 TeV

    CERN Document Server

    Affolder, T; Akopian, A M; Albrow, Michael G; Amaral, P; Amendolia, S R; Amidei, D; Antos, J; Apollinari, G; Arisawa, T; Asakawa, T; Ashmanskas, W J; Atac, Muzaffer; Azzi-Bacchetta, P; Bacchetta, N; Bailey, M W; Bailey, S; De Barbaro, P; Barbaro-Galtieri, A; Barnes, Virgil E; Barnett, B A; Barone, M; Bauer, G; Bedeschi, F; Belforte, S; Bellettini, Giorgio; Bellinger, J; Benjamin, D; Bensinger, J; Beretvas, A; Bergé, J P; Berryhill, J W; Bertolucci, Sergio; Bevensee, B; Bhatti, A A; Bigongiari, C; Binkley, M; Bisello, D; Blair, R E; Blocker, C A; Bloom, K; Blusk, S R; Bocci, A; Bodek, Arie; Bokhari, W; Bölla, G; Bonushkin, Yu; Bortoletto, Daniela; Boudreau, J; Brandl, A; Van den Brink, J; Bromberg, C; Bruner, N L; Buckley-Geer, E; Budagov, Yu A; Budd, H S; Burkett, K; Busetto, G; Byon-Wagner, A; Byrum, K L; Campbell, M; Caner, A; Carithers, W C; Carlson, J; Carlsmith, D; Cassada, J A; Castro, A; Cauz, D; Cerri, A; Chang, P S; Chang, P T; Chapman, J; Chen, C; Chen, Y C; Cheng, M T; Chertok, M; Chiarelli, G; Chirikov-Zorin, I E; Chlachidze, G; Chlebana, F S; Christofek, L S; Chu, M L; Cihangir, S; Ciobanu, C I; Clark, A G; Cobal, M; Cocca, E; Connolly, A; Conway, J; Cooper, J; Cordelli, M; Guimarães da Costa, J; Costanzo, D; Cronin-Hennessy, D; Cropp, R; Culbertson, R J; Dagenhart, D; De Jongh, F; Dell'Agnello, S; Dell'Orso, Mauro; Demina, R; Demortier, L; Deninno, M M; Derwent, P F; Devlin, T; Dittmann, J R; Donati, S; Done, J; Dorigo, T; Eddy, N; Einsweiler, Kevin F; Elias, J E; Engels, E; Erdmann, W; Errede, D; Errede, S; Fan, Q; Feild, R G; Ferretti, C; Fiori, I; Flaugher, B L; Foster, G W; Franklin, M; Freeman, J; Friedman, J; Fukui, Y; Gadomski, S; Galeotti, S; Gallinaro, M; Gao, T; García-Sciveres, M; Müller, T; Munar, A; Murat, P; Murgia, S; Musy, M; Nachtman, J; Nahn, S; Nakada, H; Nakaya, T; Nakano, I; Nelson, C; Neuberger, D; Newman-Holmes, C; Ngan, C Y P; Nicolaidi, P; Niu, H; Nodulman, L; Nomerotski, A; Oh, S H; Ohmoto, T; Ohsugi, T; Oishi, R; Okusawa, T; Olsen, J; Pagliarone, C; Palmonari, F; Paoletti, R; Papadimitriou, V; Pappas, S P; Parri, A; Partos, D S; Patrick, J; Pauletta, G; Paulini, M; Perazzo, A; Pescara, L; Phillips, T J; Piacentino, G; Pitts, K T; Plunkett, R K; Pompos, A; Pondrom, L; Pope, G; Prokoshin, F; Proudfoot, J; Ptohos, F; Punzi, G; Ragan, K; Reher, D; Ribon, A; Rimondi, F; Ristori, L; Robertson, W J; Robinson, A; Rodrigo, T; Rolli, S; Rosenson, L; Roser, R M; Rossin, R; Sakumoto, W K; Saltzberg, D; Sansoni, A; Santi, L; Sato, H; Savard, P; Schlabach, P; Schmidt, E E; Schmidt, M P; Schmitt, M; Scodellaro, L; Scott, A; Scribano, A; Segler, S L; Seidel, S; Seiya, Y; Semenov, A A; Semeria, F; Shah, T; Shapiro, M D; Shepard, P F; Shibayama, T; Shimojima, M; Shochet, M J; Siegrist, J L; Signorelli, G; Sill, A F; Sinervo, P K; Singh, P; Slaughter, A J; Sliwa, K; Smith, C; Snider, F D; Solodsky, A; Spalding, J; Speer, T; Sphicas, Paris; Spinella, F; Spiropulu, M; Spiegel, L; Stanco, L; Steele, J; Stefanini, A; Strologas, J; Strumia, F; Stuart, D; Sumorok, K; Suzuki, T; Takashima, R; Takikawa, K; Tanaka, M; Takano, T; Tannenbaum, B; Taylor, W; Tecchio, M; Teng, P K; Terashi, K; Tether, S; Theriot, D; Thurman-Keup, R M; Tipton, P; Tkaczyk, S M; Tollefson, K; Tollestrup, Alvin V; Toyoda, H; Trischuk, W; De Trocóniz, J F; Truitt, S; Tseng, J; Turini, N; Ukegawa, F; Valls, J; Vejcik, S; Velev, G V; Vidal, R; Vilar, R; Volobuev, I P; Vucinic, D; Wagner, R G; Wagner, R L; Wahl, J; Wallace, N B; Walsh, A M; Wang, C; Wang, C H; Wang, M J; Watanabe, T; Watts, T; Webb, R; Wenzel, H; Wester, W C; Wicklund, A B; Wicklund, E; Williams, H H; Wilson, P; Winer, B L; Winn, D; Wolbers, S; Wolinski, D; Wolinski, J; Worm, S; Wu, X; Wyss, J; Yagil, A; Yao, W; Yeh, G P; Yeh, P; Yoh, J K; Yosef, C; Yoshida, T; Yu, I; Yu, S; Zanetti, A; Zetti, F; Zucchelli, G C

    2000-01-01

    The transverse momentum and total cross section of e^+e^- pairs in the Z-boson region of 66

  9. Unveiling the origin of gamma-ray emission towards the W41 region with H.E.S.S. data

    Science.gov (United States)

    Méhault, Jérémie; Clapson, Andre-Claude; Fuessling, Matthias; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Barres de Almeida, U.; Bazer-Bachi, A. R.; Becherini, Y.; Behera, B.; Bernlühr, K.; Bochow, A.; Boisson, C.; Bolmont, J.; Borrel, V.; Brucker, J.; Brun, F.; Brun, P.; Bühler, R.; Bulik, T.; Büsching, I.; Boutelier, T.; Chadwick, P. M.; Charbonnier, A.; Chaves, R. C. G.; Cheesebrough, A.; Conrad, J.; Chounet, L.-M.; Clapson, A. C.; Coignet, G.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; Dickinson, H. J.; Domainko, A. Djannati-Ataü W.; Drury, L. O'c.; Dubois, F.; Dubus, G.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernan-Des, M. V.; Fiasson, A.; Fürster, A.; Fontaine, G.; Füssling, M.; Gabici, S.; Gallant, Y. A.; Gérard, L.; Gerbig, D.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Goret, P.; Güring, D.; Hampf, D.; Hauser, M.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hinton, J. A.; Hoffmann, A.; Hofmann, W.; Hofverberg, P.; Holleran, M.; Hoppe, S.; Horns, D.; Jacholkowska, A.; de Jager, O. C.; Jahn, C.; Jung, I.; Katarzynski, K.; Katz, U.; Kaufmann, S.; Kerschhaggl, M.; Khangulyan, D.; Khálifi, B.; Keogh, D.; Klochkov, D.; Kluzniak, W.; Kneiske, T.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Lamanna, G.; Lenain, J.-P.; Lohse, T.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Mau-Rin, D.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Moderski, R.; Moulin, E.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nekrassov, D.; Nguyen, N.; Nicholas, B.; Niemiec, J.; Nolan, S. J.; Ohm, S.; Olive, J.-F.; de Ona Wilhelmi, E.; Opitz, B.; Orford, K. J.; Ostrowski, M.; Panter, M.; Paz Arribas, M.; Pedaletti, G.; Pelletier, G.; Petrucci, P.-O.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raubenheimer, B. C.; Raue, M.; Rayner, S. M.; Reimer, O.; Renaud, M.; de Los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Ruppel, J.; Ryde, F.; Sahakian, V.; Santangelo, A.; Schlickeiser, R.; Schück, F. M.; Schünwald, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Shalchi, A.; Sushch, I.; Sikora, M.; Skilton, J. L.; Sol, H.; Stawarz, L.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Szostek, A.; Tam, P. H.; Tavernet, J.-P.; Terrier, R.; Tibolla, O.; Tluczykont, M.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Venter, L.; Vialle, J. P.; Viana, A.; Vincent, P.; Vivier, M.; Vülk, H. J.; Volpe, F.; Vorobiov, S.; Wagner, S. J.; Ward, M.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

    Both H.E.S.S. and MAGIC Cherenkov telescopes have observed very-high energy (VHE) gamma-ray emission from W41, a 105 years-old supernova remnant (SNR). The origin of this emission is still uncertain. Different scenarios, notably interaction with a molecular cloud or pulsar wind nebulae, have been proposed, in relation to 13 CO emission and X-ray pulsar candidates spatially coincident with the VHE excess. The improvement in event reconstruction and selection developed by the H.E.S.S. collaboration allows us to analyse this source with an unprecedented gamma-ray angular resolution. Furthermore, thanks to 5 time more H.E.S.S. data since the discovery paper, it is now possible to examine more precisely the spatial distribution of the VHE gamma-rays from W41 in com-parison with radio data. Informations provided by the 1-year Fermi-LAT catalogue will be included in the discussion of possible scenarios. The nearby SNR G22.7-0.2 (˜0.6° from W41, well within the H.E.S.S. field of view) appears to coincide with CO emission and is thus another potential VHE gamma-ray emitter.

  10. Genotoxic effects and serum abnormalities in residents of regions proximal to e-waste disposal facilities in Jinghai, China.

    Science.gov (United States)

    Li, KeQiu; Liu, ShaSha; Yang, QiaoYun; Zhao, YuXia; Zuo, JunFang; Li, Ran; Jing, YaQing; He, XiaoBo; Qiu, XingHua; Li, Guang; Zhu, Tong

    2014-07-01

    Electronic waste (e-waste) disposal is a growing problem in China, and its effects on human health are a concern. To determine the concentrations of pollutants in peripheral blood and genetic aberrations near an e-waste disposal area in Jinghai, China, blood samples were collected from 30 (age: 41±11.01 years) and 28 (age: 33±2.14 years) individuals residing within 5 and 40km of e-waste disposal facilities in Jinghai (China), respectively, during the week of October 21-28, 2011. Levels of inorganic pollutants (calcium, copper, iron, lead, magnesium, selenium, and zinc) and malondialdehyde (MDA), identities of persistent organic pollutants (POPs), micronucleus rates, and lymphocyte subsets were analyzed in individuals. Total RNA expression profiles were analyzed by group and gender. The population group living in proximity to the e-waste site displayed significantly higher mean levels of copper, zinc, lead, MDAs, POPs (B4-6DE, B7-9DE, total polychlorinated biphenyls, and BB-153). In addition, micronucleus rates of close-proximity group were higher compared with the remote group (18.27% vs. 7.32%). RNA expression of genes involved in metal ion binding and transport, oxidation/reduction, immune defense, and tumorigenesis varied between groups, with men most detrimentally affected (pwaste group (pwaste disposal facilities (≤5km) may be associated with the accumulation of potentially harmful inorganic/organic compounds and gender-preferential genetic aberrations.

  11. Structural and Dynamic Characterization of the Molecular Hub Early Region 1A (E1A) from Human Adenovirus.

    Science.gov (United States)

    Hošek, Tomáš; Calçada, Eduardo O; Nogueira, Marcela Oliveira; Salvi, Michele; Pagani, Talita Duarte; Felli, Isabella C; Pierattelli, Roberta

    2016-09-05

    The small-DNA human adenovirus encodes one of the most versatile molecular hubs, the E1A protein. This protein is essential for productive viral infection in human cells and a vast amount of biologically relevant data are available on its interactions with host proteins. Up to now, however, no high-resolution structural and dynamic information on E1A is available despite its important biological role. Among the different spliced variants of E1A, two are expressed at high level in the early stage of infection. These are 243 and 289 residues isoforms. Herein, we present their NMR characterization, showing that they are both highly disordered, but also demonstrate a certain heterogeneous behavior in terms of structural and dynamic properties. Furthermore, we present the characterization of the isolated domain of the longer variant, known as CR3. This study opens the way to understanding at the molecular level how E1A functions. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Modelos nacionais e regionais de família no pensamento social brasileiro National and Regional Family Patterns in Brazilian Social Thought

    Directory of Open Access Journals (Sweden)

    CANDICE VIDAL E SOUZA

    2001-01-01

    Full Text Available As revisões sobre os estudos clássicos de família no Brasil convergem na crítica ao patriarcalismo como modelo genérico e fixo de descrição dessa instituição, propondo que a família brasileira era uma pluralidade dispersa de experiências. Sugerimos que já nas narrativas ensaísticas sobre a identidade nacional existem modelos plurais de família brasileira, diversificados em termos da compreensão dos arranjos locais de relações familiares. Com esse objetivo, relemos, sob o eixo família-nação-região, dois conjuntos de ensaístas significativos para a construção de identidades regionais particulares (primeiro, Alfredo Ellis Jr. e Cassiano Ricardo; segundo, Alceu Amoroso Lima e Sylvio de Vasconcellos, pensadores/produtores de visões de São Paulo e de Minas Gerais, respectivamente, enquanto culturas e sociedades em grande parte caracterizadas por suas experiências de organização familiar própria.Revisions of classical studies of the family in Brazil agree in criticizing patriarchalism as a general and fixed model describing this institution, arguing that the Brazilian family was a plurality of dispersed experiences. We suggest that in the essay narratives of national identity there are already plural models of the Brazilian family, which are diversified according to local arrangements of family relations. Considering the themes family-nation-region, we review the work of two groups of important essayists on the construction of particular regional identities: Alfredo Ellis Jr. e Cassiano Ricardo; Alceu Amoroso Lima e Sylvio de Vasconcellos. We argue that these essayists articulated visions of São Paulo and Minas Gerais as cultures and societies characterized in a significant way by experiences of a proper family organization.

  13. Maxillary constriction: are there differences between anterior and posterior regions? Atresia maxilar: há diferenças entre as regiões anterior e posterior?

    Directory of Open Access Journals (Sweden)

    Regina Helena Lourenço Belluzzo

    2012-08-01

    Full Text Available OBJECTIVE: To evaluate the transverse constriction of the maxilla in both anterior and posterior regions, using Korkhaus analysis and to check whether there were any statistically significant differences within its values. METHOD: The sample comprised 341 study models. The study models were randomly selected from previous cases, without gender, age and malocclusion restrictions. The models were submitted to Korkhaus analysis. Data from these models were subjected to statistical analyzes in order to evaluate differences in anterior and posterior regions. RESULTS: The transverse discrepancies were statistically significant (pOBJETIVO: avaliar a atresia transversa da maxila em duas regiões anatômicas, anterior e posterior, através da análise de Korkhaus, e verificar se há diferença estatisticamente significativa em seus valores. MÉTODOS: a amostra foi constituída de 341 modelos de estudo iniciais, escolhidos aleatoriamente, sem restrições em relação ao sexo, à idade e à má oclusão. Os modelos foram submetidos à análise transversa de Korkhaus e os valores obtidos analisados estatisticamente, para avaliar se as atresias encontradas eram diferentes nas regiões anterior e posterior. RESULTADOS: as discrepâncias transversas são, em média, -2,84mm mais atrésicas na região anterior, sendo essa diferença estatisticamente significativa. CONCLUSÃO: os resultados mostraram que o diagnóstico diferencial é muito importante e devemos adequá-lo aos nossos planos de tratamento e, consequentemente, a uma terapia específica de expansão maior na região anterior.

  14. Heavy metals and organic compounds contamination in soil from an e-waste region in South China.

    Science.gov (United States)

    Liu, Ming; Huang, Bo; Bi, Xinhui; Ren, Zhaofang; Sheng, Guoying; Fu, Jiamo

    2013-05-01

    Heavy metals and persistent organic pollutants polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) were analyzed in 34 surface soil samples collected from farmland and 7 soil or dust samples collected from the workshops in South China, where e-waste was dismantled using primitive techniques. The results show that Cd, Cu and Hg were the most abundant metals, in particular Cd pollution was serious in farmland soils, and the median concentrations in farmland soils were beyond the environmental quality standard for soils (China Grade II). A correlation between Cd, Cu, Zn, Pb and PCBs or PBDEs was significant indicating similar sources. Among the PCB congeners, high relative similarity was observed between the e-waste dump site soil (EW1) and Aroclor 1254, implying that the technical product Aroclor 1254 was one of the major sources of PCB contamination. High concentrations of PCBs in workshop dusts (D2 and D3) (1958 and 1675 μg kg(-1)) demonstrated that the workshops dismantling electrical wires and cables, electrical motors, compressors and aluminum apparatus containing PCBs in lubricants represent strong PCB emission sources to this area. Principal component analysis (PCA) and PBDE homologue patterns verify that farmland soils surrounding the e-waste recycling sites were enriched with lower brominated congeners, and the major source of PBDEs in dust samples might potentially be associated with the extensive use of deca-mix technical products as a flame retardant. The difference between e-waste soils, dusts and farmland soils can be observed in the PCA score plot of PCBs and PBDEs, and E-waste soils and dusts exhibited more diversity than farmland soils. Furthermore, a prediction of the particular kinds of pollution from different recycling activities through the analysis of each contamination and the connections between them was investigated.

  15. Sinais e sintomas da disfunção temporomandibular nas diferentes regiões brasileiras Signs and symptoms of temporomandibular disorders across Brazilian regions

    Directory of Open Access Journals (Sweden)

    Anamaria Siriani de Oliveira

    2008-12-01

    Full Text Available O objetivo deste estudo foi avaliar a prevalência da severidade de sinais e sintomas de disfunção temporomandibular (DTM em não-pacientes nas diferentes regiões do país. Questionários foram aplicados a 2.396 universitários, dos quais 73,7% mulheres (21±5 anos e 26,3% homens (22±4 anos. Determinado o nível de severidade dos sinais e sintomas da DTM, os dados foram tratados estatisticamente, com nível de significância de 5%. Maior prevalência de sinais e sintomas de DTM foi constatada para o sexo feminino (73,03%. Na região Centro-Oeste não foi observada diferença significante entre estudantes com sinais e sintomas de DTM moderada e severa; mas aí há mais probabilidade de encontrar universitários com sinais e sintomas severos do que nas demais regiões. A região Sul apresentou maior porcentagem de estudantes com sinais e sintomas, porém com menor severidade que nas demais regiões. No Nordeste e no Sul, é mais provável encontrar universitários sem sinais e sintomas que universitárias. Pode-se concluir que a porcentagem de universitários não-pacientes portadores de algum nível de severidade de sinais e sintomas da DTM foi maior que a de não-portadores, em todas as regiões. Diferentes regiões apresentam diferentes probabilidades de se encontrarem universitários com algum sinal ou sintoma de DTM.The aim of this study was to assess prevalence of temporomandibular disorders (TMD signs and symptoms in non-patients from different Brazilian geographic areas. Questionnaires were applied to 2,396 college students, of which 73.7% were women (aged 21±5 and 26.3% men (aged 22±4. Once severity levels were classified, data were statistically treated, and significance level set at 5%. Greater percentage of TMD signs and symptoms was found in women (73.03% than among men. No significant differences between percentages of students with moderate and severe signs and symptoms were found in Central-West region - where chances of

  16. Ortodoxia e heterodoxia na discussão sobre integração regional: a origem do pensamento da CEPAL e seus desenvolvimentos posteriores

    Directory of Open Access Journals (Sweden)

    Adriana M. Amado

    2004-03-01

    Full Text Available O artigo analisa as origens heterodoxas da discussão sobre integração econômica na América Latina, sobretudo associadas à CEPAL, e mostra que as preocupações que norteavam essas discussões tinham um caráter heterodoxo. Confronta essa posição com a perspectiva atual de integração econômica, que está muito mais alinhada com as colocações caras à ortodoxia. Discute as origens dessa mudança de posição em relação ao tema a partir de insuficiências teóricas na área monetária.The paper observes the heterodox origin of the discussion on economic integration in Latin America, specially the one associated to ECLA, and highlights the concerns which supported this discussion and which had a heterodox character. This position is compared with the contemporary perspective on the economic integration issue, which is much aligned to the orthodox perspective, driving the heterodox analysis to a sceptic perspective on this issue.

  17. ¿Mercosur o Alca? Clase dominante, gobierno e inserción regional en los inicios del Kirchnerismo

    OpenAIRE

    Julián Kan

    2013-01-01

    El objetivo de este trabajo es analizar la relación entre gobierno, corporaciones empresarias de la clase dominante y los proyectos MERCOSUR y ALCA en los inicios del gobierno de Kirchner. La hipótesis principal es que los cambios en la inserción regional de Argentina desde 2003 (reconstrucción del MERCOSUR y rechazo al ALCA), tuvieron entre una de sus causas a las acciones de corporaciones como la Unión Industrial Argentina (UIA) y la Sociedad Rural Argentina (SRA). Como afirma Katz (2006) a...

  18. The socioeconomic scenario and opportunities for mature production regions; O cenario socioeconomico e oportunidades de desenvolvimento para regioes produtoras maduras

    Energy Technology Data Exchange (ETDEWEB)

    Reis, Andrea Campos; Lima, Regina Celia Palacio

    2009-07-01

    It is shown that production of oil and gas in mature fields provides good conditions for the economic and social development of the producing regions. This article presents the current social-economic scenery in areas of mature production. The authors provide a comparison between collected royalties and human development indicator in some countries with analysis of socio-economic data and comparison of results with and without the collection of royalties. Additionally, this papers offers a study of the socio-economic motivations for production in mature fields and describes several initiatives for improving living conditions for the local population. (author)

  19. A estagnação da produtividade do trabalho na indústria brasileira nos anos 1996-2007: análise nacional, regional e setorial

    Directory of Open Access Journals (Sweden)

    Edileuza Galeano

    2013-09-01

    Full Text Available O artigo apresenta uma análise regional e setorial da produtividade do trabalho na indústria nos anos  1996-2007 a partir dos dados da PIA-IBGE utilizando o método shift-share. Foi feita uma ponderação da produtividade do trabalho de cada setor e região pela sua respectiva participação no emprego nacional. Os resultados dos cálculos das componentes de crescimento da produtividade do trabalho mostraram que, na maioria dos setores e regiões, a componente de crescimento estrutural modificada tem baixa relação com o crescimento da produtividade do trabalho. Concluiu-se que o crescimento da produtividade nos setores e regiões foi mais em razão da própria competitividade regional do que das mudanças na estrutura produtiva. Verificou-se também que o crescimento das regiões menos desenvolvidas foi insuficiente para compensar o decréscimo na região Sudeste, não havendo incremento na produtividade do trabalho em nível nacional.

  20. EDUCAÇÃO E ETNICIDADE NA REGIÃO DE SANTA CRUZ DO SUL- RS. EDUCATION AND ETHNICITY IN THE REGION OF SANTA CRUZ DO SUL - RS

    Directory of Open Access Journals (Sweden)

    Mozart Linhares da Silva

    2012-11-01

    Full Text Available O objetivo deste artigo é analisar as relações entre educação, etnicidade e mobilidade social em região de colonização alemã no Rio Grande do Sul, sobretudo em Santa Cruz do Sul, Brasil, cidade com forte discurso identitário germânico. Em que pese ser uma cidade caracterizada pelo germanismo, o que se constatou nas pesquisas até aqui realizadas, abrangendo os últimos seis anos, é que a região em questão possui significativa população de não-brancos, embora invisibilizada socialmente e excluída do processo de pertencimento identitário da comunidade regional. As pesquisas realizadas nas escolas municipais, estaduais e privadas na região de Santa Cruz do Sul permitem uma análise pontual das relações entre a educação e a imobilidade social, cujo resultado pode ser avaliado na dinâmica da visibilidade/invisibilidade identitária e processos de exclusão comunitário destes grupos, nomeadamente dos afrodescendentes.The objective of this article is to analyze the relations among education, ethnicity and social mobility in the region of German colonization in Rio Grande do Sul, and mainly in Santa Cruz do Sul, Brazil, a city with strong German identity speech. Taking into consideration that it is a city characterized by Germanism, what was observed in the researches accomplished until now, including the last six years, is that the region in question has a significant population of non-white people, though socially invisible and excluded from the identitary inclusion process of the region community. The researches that were carried out in the private and public – municipal and state – schools in the region of Santa Cruz do Sul permit sharp analysis of the relations between education and social immobility, which result can be evaluated in the identitary visibility/invisibility dynamic and processes of community exclusion of those groups, nominally of Afro-descendants.

  1. Mitigation of Social Exclusion in Regions and Rural Areas – E-learning with Focus on Content Creation and Evaluation

    Directory of Open Access Journals (Sweden)

    M. Stočes

    2015-11-01

    Full Text Available Study materials and learning in general is moving online nowadays. The paper deals with lifelong learning of socially disadvantaged people. Inhabitants of rural areas represent a substantial group there. The fundamental disproportion of digital divide emerges in combination with other factors, which impacts generally. The problem requires a solution then. The main target groups selected for the study are women on maternity leave, seniors and unemployed school graduates. One of the main focuses was on educational materials and their creation and sharing. Several researches such as semi-structured interviews and surveys have been made among the groups. The results show several requirements for e-learning systems and materials. Taking the everything into account, prototype e-learning applications have been developed (web and mobile.

  2. Levels and ecological risk assessment of metals in soils from a typical e-waste recycling region in southeast China.

    Science.gov (United States)

    Zhao, Weituo; Ding, Lei; Gu, Xiaowen; Luo, Jie; Liu, Yunlang; Guo, Li; Shi, Yi; Huang, Ting; Cheng, Shenggao

    2015-11-01

    Due to the high threat to human health and the ecosystem from metals, the levels and distribution of As, Hg, Cr, Co, Ni, Cu, Zn, Cd, Pb, Mn, V, Sn, Sb, Li and Be in various layers of soil from an e-waste recycling area in Guiyu, China were investigated. The extent of pollution from the metals in soil was assessed using enrichment factors (EFs) and the Nemerow pollution index (P N ). To determine the metals' integrated potential ecological risks, the potential ecological risk index (RI) was chosen. The concentrations of Hg, Ni, Cu, Cd, Pb, Sn and Sb were mainly enriched in the topsoil. EF values (2-5) of the elements Hg, Co, Ni, Zn, Sn, Li and Be revealed their moderate enrichment status in the topsoil, derived from e-waste recycling activities. P N presented a decreasing trend in different layers in the order topsoil (0-20 cm) > deep soil (100-150 cm) > middle soil (50-100 cm) > shallow soil (20-50 cm). With higher potential ecological risk factor (E(i)), Hg and Cd are the main contributors to the potential ecological risk. With respect to the RI, all the values in soil from the study area exceeded 300, especially for the soil at sites S2, S4, S5, S7 and S8, where RI was greater than 600. Therefore, immediate remediation of the contaminated soil is necessary to prevent the release of metals and potential ecological harm.

  3. Fatores de risco e complicações em hipertensos/diabéticos de uma regional sanitária do nordeste brasileiro

    Directory of Open Access Journals (Sweden)

    Jênifa Cavalcante dos Santos

    2012-10-01

    Full Text Available Objetivou-se com este estudo identificar os fatores de risco e a complicações associadas em usuários com hipertensão/diabetes, cadastrados no HIPERDIA da Secretaria Executiva Regional VI em Fortaleza, CE. O estudo documental analítico abordou 2.691 pessoas. Do total, 73,6% eram mulheres; 44,6% tinham 60-79 anos, com média de 60,8 anos; 87,4% eram brancos, amarelos ou pardos; 63,7% tinham até oito anos de estudo; 79,7% não eram fumantes; 56,6% sedentários; 59,6% apresentavam sobrepeso/obesidade; 48,4% possuíam antecedente familiar de doença cardiovascular. Verificou-se associação entre sedentarismo e sobrepeso/obesidade com diabéticos e diabéticos hipertensos; antecedente familiar de doença cardiovascular com os hipertensos e diabéticos hipertensos; acidente vascular encefálico, doença arterial coronariana e insuficiência renal crônica com hipertensos e diabéticos hipertensos; infarto e acidente vascular encefálico com diabéticos. O antecedente familiar cardiovascular associou-se com doença arterial coronariana e infarto. Evidenciou-se a presença relevante de fatores de risco e complicações, destacando a necessidade da educação em saúde com os usuários.

  4. Regional and hormone-dependent effects of apolipoprotein E genotype on changes in bone mineral in perimenopausal women

    DEFF Research Database (Denmark)

    Gerdes, Lars Ulrik; Vestergaard, P; Hermann, Pernille;

    2001-01-01

    , whereas serum levels of alkaline phosphatase and its bone isoenzyme were higher in women with APOE 2-2 and APOE 2-3 than in women with APOE 3-3 and APOE 3-4 and lower in women with APOE 4-4. Among women not receiving hormonal-replacement therapy (HRT; n = 262), those with APOE 2-2 and APOE 2-3 had 30......-40% lower rates of femoral neck and total hip bone mineral loss than women with APOE 3-3 and APOE 3-4, whereas the rates of mineral loss in other skeletal regions did not differ between these APOE genotypes. Women with APOE 4-4 appeared to have lower rates of bone mineral loss in all regions. Women treated...... with hormones throughout the follow-up period (n = 113) gained bone mineral, and women with APOE 3-4 and APOE 4-4 gained relatively more mineral than other women. A comparison of untreated and treated women with APOE 2-3, APOE 3-3, and APOE 3-4 suggests a possible modification of the effect of APOE genotype...

  5. Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer.

    Science.gov (United States)

    Ko, Bong-Kook; Choi, Soyoung; Cui, Lei Guang; Lee, Young-Ha; Hwang, In-Sik; Kim, Kyu-Tae; Shim, Hyunbo; Lee, Jong-Seo

    2015-01-01

    Anti-HER2 murine monoclonal antibody 1E11 has strong and synergistic anti-tumor activity in HER2-overexpressing gastric cancer cells when used in combination with trastuzumab. We presently optimized this antibody for human therapeutics. First, the complementarity determining regions (CDRs) of the murine antibody were grafted onto human germline immunoglobulin variable genes. No difference in affinity and biological activity was observed between chimeric 1E11 (ch1E11) and humanized 1E11 (hz1E11). Next, affinity maturation of hz1E11 was performed by the randomization of CDR-L3 and H3 residues followed by stringent biopanning selection. Milder selection pressure favored the selection of more diverse clones, whereas higher selection stringency resulted in the convergence of the panning output to a smaller number of clones with improved affinity. Clone 1A12 had four amino acid substitutions in CDR-L3, and showed a 10-fold increase in affinity compared to the parental clone and increased potency in an in vitro anti-proliferative activity assay with HER2-overepxressing gastric cancer cells. Clone 1A12 inhibited tumor growth of NCI-N87 xenograft model with similar efficacy to trastuzumab alone, and the combination treatment of 1A12 and trastuzumab completely removed the established tumors. These results suggest that humanized and affinity matured monoclonal antibody 1A12 is a highly optimized molecule for future therapeutic development against HER2-positive tumors.

  6. Regional variation in the prevalence of E. coli O157 in cattle: a meta-analysis and meta-regression.

    Directory of Open Access Journals (Sweden)

    Md Zohorul Islam

    Full Text Available Escherichia coli O157 (EcO157 infection has been recognized as an important global public health concern. But information on the prevalence of EcO157 in cattle at the global and at the wider geographical levels is limited, if not absent. This is the first meta-analysis to investigate the point prevalence of EcO157 in cattle at the global level and to explore the factors contributing to variation in prevalence estimates.Seven electronic databases- CAB Abstracts, PubMed, Biosis Citation Index, Medline, Web of Knowledge, Scirus and Scopus were searched for relevant publications from 1980 to 2012. A random effect meta-analysis model was used to produce the pooled estimates. The potential sources of between study heterogeneity were identified using meta-regression.A total of 140 studies consisting 220,427 cattle were included in the meta-analysis. The prevalence estimate of EcO157 in cattle at the global level was 5.68% (95% CI, 5.16-6.20. The random effects pooled prevalence estimates in Africa, Northern America, Oceania, Europe, Asia and Latin America-Caribbean were 31.20% (95% CI, 12.35-50.04, 7.35% (95% CI, 6.44-8.26, 6.85% (95% CI, 2.41-11.29, 5.15% (95% CI, 4.21-6.09, 4.69% (95% CI, 3.05-6.33 and 1.65% (95% CI, 0.77-2.53, respectively. Between studies heterogeneity was evidenced in most regions. World region (p<0.001, type of cattle (p<0.001 and to some extent, specimens (p = 0.074 as well as method of pre-enrichment (p = 0.110, were identified as factors for variation in the prevalence estimates of EcO157 in cattle.The prevalence of the organism seems to be higher in the African and Northern American regions. The important factors that might have influence in the estimates of EcO157 are type of cattle and kind of screening specimen. Their roles need to be determined and they should be properly handled in any survey to estimate the true prevalence of EcO157.

  7. The influence of synoptic airflow on UK daily precipitation extremes. Part II: regional climate model and E-OBS data validation

    Energy Technology Data Exchange (ETDEWEB)

    Maraun, Douglas [Leibniz Institute of Marine Sciences (IFM-GEOMAR), Duesternbrooker Weg 20, 24105, Kiel (Germany); Osborn, Timothy J. [School of Environmental Sciences, Climatic Research Unit, Norwich (United Kingdom); Rust, Henning W. [Freie Universitaet Berlin, Institut fuer Meteorologie, Berlin (Germany)

    2012-07-15

    We investigate how well the variability of extreme daily precipitation events across the United Kingdom is represented in a set of regional climate models and the E-OBS gridded data set. Instead of simply evaluating the climatologies of extreme precipitation measures, we develop an approach to validate the representation of physical mechanisms controlling extreme precipitation variability. In part I of this study we applied a statistical model to investigate the influence of the synoptic scale atmospheric circulation on extreme precipitation using observational rain gauge data. More specifically, airflow strength, direction and vorticity are used as predictors for the parameters of the generalised extreme value (GEV) distribution of local precipitation extremes. Here we employ this statistical model for our validation study. In a first step, the statistical model is calibrated against a gridded precipitation data set provided by the UK Met Office. In a second step, the same statistical model is calibrated against 14 ERA40 driven 25 km resolution RCMs from the ENSEMBLES project and the E-OBS gridded data set. Validation indices describing relevant physical mechanisms are derived from the statistical models for observations and RCMs and are compared using pattern standard deviation, pattern correlation and centered pattern root mean squared error as validation measures. The results for the different RCMs and E-OBS are visualised using Taylor diagrams. We show that the RCMs adequately simulate moderately extreme precipitation and the influence of airflow strength and vorticity on precipitation extremes, but show deficits in representing the influence of airflow direction. Also very rare extremes are misrepresented, but this result is afflicted with a high uncertainty. E-OBS shows considerable biases, in particular in regions of sparse data. The proposed approach might be used to validate other physical relationships in regional as well as global climate models. (orig.)

  8. Economic globalisation. Regional integration and protection of foreign investments in Brazil Globalização econômica. Integração regional e proteção de inversões estrangeiras no Brasil

    Directory of Open Access Journals (Sweden)

    Luis Maria Chamorro Coronado

    2009-12-01

    Full Text Available Economic globalization poses a challenge to enterprises looking for new markets. These enterprises search for new markets in countries that belong to regional integration organizations whose regulations- as well as those of the internal system of each country - shape the legal framework for foreign investments. Foreign enterprises investing in Brazil, for instance, are affected by Brazilian law as well as by Mercosur regulations. This article focuses on the Multilateral Investment Guarantee Agency and its insurance schemes - an institution that protects foreign investment in Brazil - as well as on a description of the Multilateral Conventions which rule the treatment and protection of foreign investments. This article concludes with a review of Mercosur´s main legal documents to protect investments and their interaction with Bilateral Investment Treaties, containing the new international law on foreign investments. To this day, Brazil has signed some bilateral investment treaties but has not yet ratified them.A globalização econômica tem posto um desafio às empresas que buscam novos mercados. Introduzem-se em países que pertencem a Organizações de integração regional, cujas normas, além das internas de cada país, configuram o marco jurídico de suas intervenções. As empresas estrangeiras que investem no Brasil ficam, portanto, afetadas pelo Direito brasileiro e à sua pertinência ao MERCOSUL. Como passo prévio ao estudo do sistema mais adequado à proteção dos investimentos no Brasil, e do Organismo Multilateral de garantia de Investimento, e seus esquemas de asseguramento, o presente trabalho contém a descrição dos Convênios multilaterais que regulam o tratamento e proteção dos investimentos exteriores. O artigo conclui com o estudo dos intrumentos legais para a proteção dos investimentos no MERCOSUL e sua interação com os Acordos de Promoção e Proteção Recíproca de Investimento (APPRIs, que contêm o novo

  9. Low-frequency lower E-region wind and reflection height measurements as sensor for climate variability

    Directory of Open Access Journals (Sweden)

    C. Jacobi

    2008-07-01

    Full Text Available Measurements of reflection heights of low-frequency (LF radio waves at oblique incidence and estimates of mesosphere/lower thermosphere (MLT region horizontal winds applying the D1 spaced receiver method on LF field strength registrations are analyzed with respect to possible long-term trends and interdecadal variability in the time interval from ~1980 to date. While no clear signal of mesospheric height trend is registered during the last two decades, significant trends of MLT horizontal winds are found. These trends are non-linear, in particular a change of trends around 1990 is found, which is probably connected with changes in tropospheric and stratospheric conditions at that time.

  10. Characterization of limestone of region South and Southeast of Para; Caracterizacao de calcario da regiao Sul e Sudeste do Para

    Energy Technology Data Exchange (ETDEWEB)

    Marinho, A.R.O.; Vieira, J.H.A.; Antunes Junior, L.V.; Medeiros, A.C.; Souza, G.P., E-mail: marabaonline@gmail.com [Universidade Federal do Sul e Sudeste do Para (FEMAT/UNIFESSPA), Maraba, PA (Brazil)

    2014-07-01

    Limestone is used in daily activities, and it is common the use of products containing calcium carbonate in various applications, from construction to food production, air purification to sewage treatment, the sugar refining materials for the toothpaste, the manufacture of glass and steel in the manufacture of paper, plastics, paints, ceramics and many others. The Limestone present in the region of south and southeast of Para is presented in deposits that have not been explored on a large scale, being justified a deepening in characteristics thereof. For the characterization of the material, gross samples were comminuted by crushing and ball mill, sieved and then separated into aliquots. In the end were used fluorescence analysis of X-ray, diffraction X-rays, determination of the moisture and loss on ignition of the material at 950 °C for one hour, obtaining results of a dolomitic limestone. (author)

  11. Perceptions on hospitality when visiting secluded communities of guaranis, caiçaras e quilombolas in Paraty region

    Directory of Open Access Journals (Sweden)

    Luis Alberto Beares

    2008-10-01

    Full Text Available Tourism in secluded communities puts different cultures in contact with each other and must be handled carefully not to cause environmental damage as well as cultural loss which might jeopardize the local development and create hostile relationships. The proposal of in sito tourism, considering the local memory and patrimony as a hospitality potential, was observed during technical visitations to three communities located in the Paraty region and surroundings: Guarani, Caiçara (fishermen and Quilombola(African slaves descendants. Through field work involving visitations to communities and interviews with locals, information regarding cultural differences and the importance of the land occupation in the history of each of the communities was assessed. The common link in the history of these peoples is the struggle for the right of land possession. During visits when people shared their territory various forms of hospitality in each community were verified, issued from different cultures and cultural values.

  12. Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion.

    Science.gov (United States)

    Senoo, Makoto; Wang, Lili; Suzuki, Daisuke; Takeda, Naoki; Shinkai, Yoichi; Habu, Sonoko

    2003-07-15

    Seventy percent of the murine TCRbeta locus (475 kb) was deleted to generate a large deleted TCRbeta (beta(LD)) allele to investigate a possible linkage between germline transcription, recombination frequency, and allelic exclusion of the TCR Vbeta genes. In these beta(LD/LD) mice, the TCRbeta gene locus contained only four Vbeta genes at the 5' side of the locus, and consequently, the Vbeta10 gene was located in the original Dbeta1-Jbeta1cluster within the Ebeta regulatory region. We showed that the frequency of recombination and expression of the Vbeta genes are strongly biased to Vbeta10 in these mutant mice even though the proximity of the other three 5'Vbeta genes was also greatly shortened toward the Dbeta-Jbeta cluster and the Ebeta enhancer. Accordingly, the germline transcription of the Vbeta10 gene in beta(LD/LD) mice was exceptionally enhanced in immature double negative thymocytes compared with that in wild-type mice. During double negative-to-double positive transition of thymocytes, the level of Vbeta10 germline transcription was prominently increased in beta(LD/LD) recombination activating gene 2-deficient mice receiving anti-CD3epsilon Ab in vivo. Interestingly, however, despite the increased accessibility of the Vbeta10 gene in terms of transcription, allelic exclusion of this Vbeta gene was strictly maintained in beta(LD/LD) mice. These results provide strong evidence that increase of Vbeta accessibility influences frequency but not allelic exclusion of the TCR Vbeta rearrangement if the Vbeta gene is located in the Ebeta regulatory region.

  13. Health assessment for E. H. Schilling Landfill, Ironton, Lawrence County, Ohio, Region 5. CERCLIS No. OHD980509847. Preliminary report

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-02

    The E.H. Schilling Landfill site is listed on the National Priorities List. The five-acre site was a landfill, licensed to accept only nonhazardous dry industrial waste, from 1971 until 1980 when it was closed. The environmental contamination on-site consists of polychlorinated biphenyls, vinyl toluene, cumene, polynuclear aromatic hydrocarbons or PAHs, including fluoranthene, benzo(a)pyrene, and benzo(a)anthracene, in soil. The site is considered to be of potential public health concern because of the risk to human health caused by the possibility of exposure to hazardous substances via ground water, soil, sediment, surface water, and air.

  14. A influência da proximidade tecnológica e geográfica sobre a inovação regional no Brasil The influence of the technological proximity and the geographical proximity on Brazilian regional innovation

    Directory of Open Access Journals (Sweden)

    Eduardo Gonçalves

    2011-04-01

    Full Text Available O objetivo deste trabalho é verificar a influência da proximidade geográfica e da proximidade tecnológica sobre a inovação regional no Brasil, medida por depósitos de patentes no período 1999-2001 para mesorregiões geográficas. Para tanto, utilizaram-se técnicas de Análise Exploratória de Dados Espaciais (AEDE e de econometria espacial. Os dados de patentes foram organizados em quatro clusters tecnológicos segundo critérios de proximidade cognitiva, como biofarmacêutico, desenvolvimento de novos materiais, bens mecânicos e de consumo e tecnologias eletroeletrônicas, revelando um padrão de concentração da atividade tecnológica em poucas mesorregiões brasileiras. Além disso, foi calculada a medida de proximidade tecnológica de Jaffe para ponderar a vizinhança geográfica pelo grau de similaridade tecnológica das mesorregiões. Os resultados confirmam a hipótese de transbordamentos de conhecimento mediados tecnológica e geograficamente.The aim of this paper is to determine the influence of technological proximity and geographical proximity on Brazilian regional innovation, measured by patent applications over the period 1999-2001 for Brazilian geographical mesoregions. First, the paper undertakes an Exploratory Spatial Data Analysis (ESDA and then uses spatial econometric techniques. According with procedures based on cognitive proximity the patent data are organized into four technological clusters such as chemical and bio-pharmaceutical, new materials, mechanical and process technologies and electrical and electronic technologies. The four aforementioned clusters exhibit a concentrated regional pattern of technological activity over few Brazilian mesoregions. Moreover, the paper uses a Jaffe's measure of technological distance in order to construct a matrix in which the technological similarity is weighted by the geographical proximity. The results corroborate the hypothesis of geographically and technologically

  15. Development of three PCR assays for the differentiation between Echinococcus shiquicus, E. granulosus (G1 genotype), and E. multilocularis DNA in the co-endemic region of Qinghai-Tibet plateau, China.

    Science.gov (United States)

    Boufana, Belgees; Umhang, Gérald; Qiu, Jiamin; Chen, Xingwang; Lahmar, Samia; Boué, Franck; Jenkins, David; Craig, Philip

    2013-04-01

    To investigate echinococcosis in co-endemic regions, three polymerase chain reaction (PCR) assays based on the amplification of a fragment within the NADH dehydrogenase subunit 1 (ND1) mitochondrial gene were optimized for the detection of Echinococcus shiquicus, Echinococcus granulosus G1, and Echinococcus multilocularis DNA derived from parasite tissue or canid fecal samples. Specificity using parasite tissue-derived DNA was found to be 100% except for E. shiquicus primers that faintly detected E. equinus DNA. Sensitivity of the three assays for DNA detection was between 2 and 10 pg. Ethanol precipitation of negative PCR fecal samples was used to eliminate false negatives and served to increase sensitivity as exemplified by an increase in detection from 0% to 89% of E. shiquicus coproDNA using necropsy-positive fox samples.

  16. Os diferentes papéis, propósitos e resultados dos modelos nacionais e regionais de educação Different roles, purposes and outcomes of national and regional models of education

    Directory of Open Access Journals (Sweden)

    Roger Dale

    2009-10-01

    Full Text Available Este artigo discute a natureza e as posturas, atualmente variáveis, da educação por meio da distinção entre os papéis, propósitos e resultados de modelos educativos em níveis nacional e regional (supranacional, não subnacional. Propõe também o surgimento de um novo tipo de modelo regional de educação, que difere dos modelos nacionais em termos de conteúdo, papel e objetivo, e mantém com eles uma relação que não é de hierarquia, de convergência nem de escala. Comparam-se seus papéis no contrato social pela educação, tendo o Sistema Nacional de Educação como modelo-"padrão". Embora ambos sejam parte das contribuições da educação para os meios de produção e distribuição de bem-estar, desempenham papéis diferentes. Como exemplos, o artigo examina o processo Bolonha, na União Europeia (UE, e a natureza e as possíveis consequências do projeto que busca "exportá-lo" para a América Latina. Esses dois casos sugerem que os resultados-chave envolvem a "re-construção" tanto da região quanto, e mais particularmente, da educação superior como setor. O artigo conclui propondo que esses desenvolvimentos podem culminar em divisões funcionais, escalares e setoriais do trabalho educacional.This paper discusses the currently changing nature and roles of education through distinguishing between the roles, purposes and outcomes of educational models at national and regional (supra- rather than sub-national levels. It proposes the emergence of a new kind of regional model of education, that differs from national models in content, role and purpose, and where the relationship between the two models is neither hierarchical, converging or scaled-up. The two models are compared in terms of their role in the social contract for education, and the national education system is taken as the 'default' model. While both models are part of education's contribution to the means of production and distribution of well-being, they play

  17. AVALIAÇÃO DOS BENEFÍCIOS SECUNDÁRIOS DE PROJETOS MDL: CONTRIBUIÇÃO AO CONTROLE DE POLUIÇÃO E AO DESENVOLVIMENTO LOCAL E REGIONAL

    Directory of Open Access Journals (Sweden)

    Pedro Camargo Amaral

    2011-05-01

    Full Text Available Considerando o aumento da importância de poluentes locais, regionais e globais nas atividades humanas, notados os acordos internacionais para controlar e reduzir as emissões de gases de efeito estufa destaca-se o Mecanismo de Desenvolvimento Limpo do Protocolo de Kyoto, como ferramenta para promover a redução de emissões de GEE e contribuir para o controle de poluição e desenvolvimento local e regional. Dentro do processo de aprovação de projetos de MDL no Brasil, existe a necessidade de se atender aos critérios relacionados à sustentabilidade local, definidos pelo governo brasileiro no documento denominado Anexo III. O presente estudo busca avaliar o processo que culminou com a definição dos critérios de sustentabilidade para projetos de MDL no Brasil e avaliar o impacto local e regional de projetos aprovados pelo governo brasileiro, no que concerne os poluentes ambientais CO, NOx, SOx, MP e hidrocarbonetos, assim como impactos diretos à fauna, flora e recursos hídricos. Para a avaliação dos projetos foi proposta uma metodologia, baseada em metodologias previamente sugeridas para avaliação de projetos de MDL. Concluí-se que os critérios estabelecidos para o Anexo III contemplam, em essência, os critérios sugeridos nos trabalhos que antecederam sua definição. Por outro lado, é notável a diminuição do peso de benefícios secundários no mecanismo, como critérios obrigatórios ou classificatórios, quando se comparam as idéias originais àquelas que de fato foram implementadas. Ao mesmo tempo, devem ser valorizados os impactos secundários positivos advindos dos projetos de MDL, notados àqueles apresentados neste trabalho. Ressalta-se que os impactos ambientais positivos são extremamente relacionados ao menor consumo de combustíveis fósseis (não desconsiderando também a menor necessidade de produção dos mesmos e aos impactos associados a estes combustíveis.

  18. THE SEARCH FOR A COMPLEX MOLECULE IN A SELECTED HOT CORE REGION: A RIGOROUS ATTEMPT TO CONFIRM TRANS-ETHYL METHYL ETHER TOWARD W51 e1/e2

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, P. Brandon; McGuire, Brett A. [Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Blake, Geoffrey A. [Division of Chemistry and Chemical Engineering and Division Geological and Planetary Sciences, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Apponi, A. J.; Ziurys, L. M. [Departments of Chemistry and Astronomy, University of Arizona, 933 North Cherry Avenue, Tucson, AZ 85721 (United States); Remijan, Anthony, E-mail: pcarroll@caltech.edu [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22901-2475 (United States)

    2015-01-20

    An extensive search has been conducted to confirm transitions of trans-ethyl methyl ether (tEME, C{sub 2}H{sub 5}OCH{sub 3}), toward the high-mass star forming region W51 e1/e2 using the 12 m Telescope of the Arizona Radio Observatory at wavelengths from 2 mm and 3 mm. In short, we cannot confirm the detection of tEME toward W51 e1/e2 and our results call into question the initial identification of this species by Fuchs et al. Additionally, re-evaluation of the data from the original detection indicates that tEME is not present toward W51 e1/e2 in the abundance reported by Fuchs and colleagues. Typical peak-to-peak noise levels for the present observations of W51 e1/e2 were between 10 and 30 mK, yielding an upper limit of the tEME column density of ≤1.5 × 10{sup 15} cm{sup –2}. This would make tEME at least a factor of two times less abundant than dimethyl ether (CH{sub 3}OCH{sub 3}) toward W51 e1/e2. We also performed an extensive search for this species toward the high-mass star forming region Sgr B2(N-LMH) with the National Radio Astronomy Observatory 100 m Green Bank Telescope. No transitions of tEME were detected and we were able to set an upper limit to the tEME column density of ≤4 × 10{sup 14} cm{sup –2} toward this source. Thus, we are able to show that tEME is not a new molecular component of the interstellar medium and that an exacting assessment must be carried out when assigning transitions of new molecular species to astronomical spectra to support the identification of large organic interstellar molecules.

  19. Descentralização e formação continuada de professores na RMC Decentralization and teachers’ continuous training in the metropolitan region of Campinas (RMC

    Directory of Open Access Journals (Sweden)

    Vicente Rodriguez

    2012-08-01

    Full Text Available Novas formas institucionais para oferta de formação continuada de professores têm se apresentado na Região Metropolitana de Campinas (RMC. Procuramos, com este artigo, compreender como se tem dado esse processo, considerando o contexto descentralizado das políticas públicas educacionais e os problemas de gestão pública brasileira e metropolitana. Investigando e analisando diversos índices da última década, como: evolução do número de professores, investimento e matrículas nos diversos níveis da educação básica e por instância administrativa, pudemos verificar determinados aspectos e reflexos dessas políticas, principalmente quando se trata de novas formas de arranjos entre o público e o privado. Percebemos o aumento da participação das diversas formas não estatais, incluindo o mercado, na oferta de formação continuada de professores e gestão educacional, entre outras formas não menos relevantes.New institutional arrangements for the provisions of teachers continuous training has been performed in the Metropolitan Region of Campinas (RMC. In this article, we seek to understand how this process goes on, considerating the context for decentralized public policies and educational problems in Brazil and metropolitan governance. Investigating and examinating various indices of the lasted decade, like growth in the numbers of teachers, investments and enrollment at all levels of basic education and administrative level, we could verify certains aspects and consequences of these policies, especially when it comes to new forms of arrangements between public and private. It was noted the increased participation of various non-governmental forms, including the market in offering continuing education for teachers and educational administration as any other forms no less relevant to perform it.

  20. AGRICULTURA CIENTÍFICA E O PLANEJAMENTO REGIONAL: O PERÍMETRO DE IRRIGAÇÃO FORMOSO

    Directory of Open Access Journals (Sweden)

    Suelí Almeida dos Santos

    2016-12-01

    Full Text Available O presente artigo tem como objetivo contribuir para o entendimento da dinâmica socioespacial da economia de Bom Jesus da Lapa (BA a partir da análise da produção de frutas através do sistema de irrigação. No município lapense o dinamismo econômico tem como base o turismo religioso (cidade-santuário, a produção de frutas e a oferta de comércio e serviços modernos. Este trabalho dedica-se a análise do Perímetro de Irrigação Formoso enquanto pólo produtor de frutas. A metodologia pautou-se num levantamento de dados em campo, bem como em fontes secundárias. Com isso, procura-se demonstrar a importância atual da fruticultura para a economia lapense.

  1. Determinantes espaciais e socioeconômicos do suicídio no Brasil: uma abordagem regional

    Directory of Open Access Journals (Sweden)

    Ludmilla R. C. Gonçalves

    2012-01-01

    Full Text Available A Organização Mundial da Saúde avalia o suicídio como um problema de saúde pública, estando entre as dez causas mais frequentes de morte, além de ser a segunda ou terceira causa de morte entre 15 e 34 anos de idade. Estimativas mostram que para cada suicídio, existem pelo menos dez tentativas suficientemente sérias que exigem atenção médica e para cada tentativa de suicídio registrada, existem quatro não conhecidas. O objetivo desse artigo é avaliar os determinantes socioeconômicos das taxas de suicídio por microrregiões brasileiras, levando em consideração aspectos espaciais do problema. A hipótese desse artigo é que existe um “efeito contágio” espacial para o suicídio, ou seja, as taxas de suicídio dos vizinhos de uma microrregião são importantes determinantes do comportamento dessa variável em outra microrregião. Para tal, são usadas técnicas de econometria espacial que permitem avaliar se existe dependência espacial entre as taxas de suicídio das microrregiões.

  2. Cineturismo e valorizzazione del territorio: il caso Puglia / Cine-tourism and territory enhancement: the case of Puglia region

    Directory of Open Access Journals (Sweden)

    Michele Vigilante

    2016-05-01

    Full Text Available Il cineturismo rappresenta un fenomeno socio-culturale recente e in forte diffusione in Italia. Il suo legame con la valorizzazione del territorio è inscindibile dal momento in cui lo spettatore sceglie un determinato luogo da visitare, stimolato dalla visione di un film, di una fiction o di un cortometraggio. La valorizzazione del territorio attraverso il cinema non è automatica. Vi sono luoghi che grazie a dei film di successo hanno riscontrato un afflusso esponenziale di turisti e altri luoghi dove questo non è avvenuto. Predisporre spazi per l'accoglienza di produzioni cinematografiche o finanziare le produzioni cinematografiche in uno specifico territorio consente un maggiore interesse, da parte dei registi, nei confronti di quelle location che di quel territorio fanno parte.  The film tourism is a socio-cultural phenomenon recently and rapidly spread in Italy. His connection with the development of the area is inseparable from the moment when the viewer chooses a certain place to visit, stimulated by watching a movie, a drama or a short film. The development of the area through cinema is not automatic. There are places that thanks to the hit movie found an exponential influx of tourists and other places where this has not happened. Provide space for the reception of film productions or finance film productions in a specific area allows a greater interest on the part of directors, in respect of those locations that are part of that territory.

  3. Identidade, alteridade e cultura regional: a construção do ethos milongueiro gaúcho

    Directory of Open Access Journals (Sweden)

    Maria da Glória Corrêa Di Fanti

    2009-07-01

    Full Text Available

    Considerando a importância de se conhecer o gênero musical milonga, que representa de modo peculiar a cultura gaúcha, este trabalho tem o objetivo de analisar aspectos relativos à construção discursiva do ethos do enunciador da milonga-canção, procurando apreender características da atividade de composição da milonga. A metodologia da presente reflexão é desenvolvida de modo a responder às seguintes questões: Qual o ethos que se constrói no discurso de duas diferentes milongas de um mesmo compositor? Que características do milongueiro podem ser apreendidas a partir das canções analisadas? Como embasamento teórico, a análise do discurso de base enunciativa e a teoria bakhtiniana proporcionam a observação de como o sujeito enunciador se constrói na relação com o outro nos discursos que atravessam o seu dizer, propiciando a observação da tensão entre identidade e alteridade na tessitura das milongas, de modo a apreender responsivamente características que acenam para a construção discursiva de um jeito milongueiro de ser.

  4. Discovery of VHE emission towards the Carina arm region with the H.E.S.S. telescope array: HESS J1018-589

    Science.gov (United States)

    H. E. S. S. Collaboration; Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker, J.; Bernlöh, K.; Birsin, E.; Biteau, J.; Bochow, A.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Büsching, I.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Charbonnier, A.; Chaves, R. C. G.; Cheesebrough, A.; Cologna, G.; Conrad, J.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O'C.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gallant, Y. A.; Gast, H.; Gérard, L.; Gerbig, D.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Häffner, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Hauser, M.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; de Jager, O. C.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Keogh, D.; Khélifi, B.; Klochkov, D.; Klużniak, D.; Kneiske, T.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Laffon, H.; Lamanna, G.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nekrassov, D.; Nguyen, N.; Nicholas, B.; Niemiec, J.; Nolan, S. J.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raue, M.; Rayner, S. M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

    2012-05-01

    The Carina arm region, containing the supernova remnant SNR G284.3-1.8, the high-energy (HE; E > 100 MeV) binary 1FGL J1018.6-5856 and the energetic pulsar PSR J1016-5857 and its nebula, has been observed with the H.E.S.S. telescope array. The observational coverage of the region in very-high-energy (VHE; E > 0.1 TeV) γ-rays benefits from deep exposure (40 h) of the neighboring open cluster Westerlund 2. The observations have revealed a new extended region of VHE γ-ray emission. The new VHE source HESS J1018-589 shows a bright, point-like emission region positionally coincident with SNR G284.3-1.8 and 1FGL J1018.6-5856 and a diffuse extension towards the direction of PSR J1016-5857. A soft (Γ = 2.7 ± 0.5stat)photon index, with a differential flux at 1 TeV of N0 = (4.2 ± 1.1) × 10-13 TeV-1 cm-2 s-1 is found for the point-like source, whereas the total emission region including the diffuse emission region is well fit by a power-law function with spectral index Γ = 2.9 ± 0.4stat and differential flux at 1 TeV of N0 = (6.8 ± 1.6) × 10-13 TeV-1 cm-2 s-1. This H.E.S.S. detection motivated follow-up X-ray observations with the XMM-Newton satellite to investigate the origin of the VHE emission. The analysis of the XMM-Newton data resulted in the discovery of a bright, non-thermal point-like source (XMMU J101855.4-58564) with a photon index of Γ = 1.65 ± 0.08 in the center of SNR G284.3-1.8, and a thermal, extended emission region coincident with its bright northern filament. The characteristics of this thermal emission are used to estimate the plasma density in the region as n ≈ 0.5 cm-3 (2.9 kpc/d)2. The position of XMMU J101855.4-58564 is compatible with the position reported by the Fermi-LAT collaboration for the binary system 1FGL J1018.6-5856 and the variable Swift XRT source identified with it. The new X-ray data are used alongside archival multi-wavelength data to investigate the relationship between the VHE γ-ray emission from HESS J1018-589 and the

  5. Lower mutation frequency of BCP/precore regions in e antigen-negative chronic HBV-infected children instead of adults patients.

    Directory of Open Access Journals (Sweden)

    Yong Huang

    Full Text Available To describe the Hepatitis B e antigen(HBeAg seroconversion related mutation profiles of the basal core promoter(BCP/precore regions in e antigen seroconverted child patients, a cohort of 245 child patients with CHB and a control patients group of 92 adult patients with CHB were recruited. The mutation frequencies of six nucleotides or nucleotide combinations including nucleotide (nt1896, nt1762/1764, nt1752, nt1846, nt1899 and nt1753 showed significant differences between HBeAg positive and HBeAg-negative child patients groups. The frequencies of these HBeAg seroconversion-related mutations were significantly lower in HBeAg-negative children with CHB than in HBeAg-negative adults with CHB, especially for the mutation G1896A (41.1% vs 91.7%, P<0.001, and the average number of BCP/precore region mutations in samples from HBeAg-negative child patients was also obviously lower than in HBeAg-negative adult patients(3.62±3.03 vs 4.89±2.09, P<0.001, suggesting less impact of mutations in the BCP/precore region on HBeAg seroconversion in child patients than adult patients.

  6. Setor educacional do MERCOSUL: convergência e integração regional da educação superior brasileira

    Directory of Open Access Journals (Sweden)

    Zuleide S. Silveira

    Full Text Available Resumo: Este trabalho busca apreender as recentes modificações na educação superior brasileira por meio de duas mediações principais: o Estado brasileiro e o Setor Educacional do Mercado Comum do Sul (SEM. O contexto é de internacionalização da economia e de relações sociopolíticas que consistem nas formas históricas de estruturas articuladas institucionalmente na organização e funcionamento da educação. Evidencia os esforços de gestão supranacional dos assuntos educacionais ao mesmo tempo em que procura compreender a relação entre a grande política (formulada em nível supranacional no SEM e a pequena política, levada adiante no aparelho de Estado brasileiro, em tono da formulação das políticas públicas de educação superior. Desvela os mecanismos institucionais que vêm propiciando a integração e regionalização da educação superior por meio de dois vetores direcionadores da reforma da educação superior: avaliação e mobilidade. O tempo da pesquisa remonta à gênese do MERCOSUL, no início dos anos 1990, estendendo-se até os dias atuais, com base na análise documental de atas de reuniões, protocolos, planos de ação, tratados e acordos firmados no âmbito do SEM e pelo conjunto de indicações e de legislação formuladas nos mandatos de governos brasileiros, no período 1995-2014, de modo a acrescentar a dimensão do tempo à compreensão da ação política dos sujeitos envolvidos na formulação das políticas de educação superior em âmbito regional e nacional; e, à apreensão dos embates de forças com disputas teóricas e políticas em torno da reforma da educação superior.

  7. Gene movement and genetic association with regional climate gradients in California valley oak (Quercus lobata Née) in the face of climate change

    Science.gov (United States)

    Sork, Victoria L.; Davis, Frank W.; Westfall, Robert; Flint, Alan L.; Ikegami, Makihiko; Wang, Hongfang; Grivet, Delphine

    2010-01-01

    Rapid climate change jeopardizes tree populations by shifting current climate zones. To avoid extinction, tree populations must tolerate, adapt, or migrate. Here we investigate geographic patterns of genetic variation in valley oak, Quercus lobata N??e, to assess how underlying genetic structure of populations might influence this species' ability to survive climate change. First, to understand how genetic lineages shape spatial genetic patterns, we examine historical patterns of colonization. Second, we examine the correlation between multivariate nuclear genetic variation and climatic variation. Third, to illustrate how geographic genetic variation could interact with regional patterns of 21st Century climate change, we produce region-specific bioclimatic distributions of valley oak using Maximum Entropy (MAXENT) models based on downscaled historical (1971-2000) and future (2070-2100) climate grids. Future climatologies are based on a moderate-high (A2) carbon emission scenario and two different global climate models. Chloroplast markers indicate historical range-wide connectivity via colonization, especially in the north. Multivariate nuclear genotypes show a strong association with climate variation that provides opportunity for local adaptation to the conditions within their climatic envelope. Comparison of regional current and projected patterns of climate suitability indicates that valley oaks grow in distinctly different climate conditions in different parts of their range. Our models predict widely different regional outcomes from local displacement of a few kilometres to hundreds of kilometres. We conclude that the relative importance of migration, adaptation, and tolerance are likely to vary widely for populations among regions, and that late 21st Century conditions could lead to regional extinctions. ?? 2010 Blackwell Publishing Ltd.

  8. Measurement of neutron total cross-sections of Dy and Hf in the energy region from 0.002 eV to 100 keV

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Hyun-Je; Kobayashi, Katsuhei; Yamamoto, Shuji; Fujita, Yoshiaki [Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst; Kim, Guinyun [Pohang Accelerator Laboratory, POSTECH, Hyojadong Namgu, Pohang (Korea); Ko, Seung Kook [Department of Physics, University of Ulsan, Moogedong Namgu, Ulsan (Korea)

    2000-03-01

    The neutron total cross-sections of Dy and Hf have been measured in the energy region from 0.002 eV to 100 eV by the neutron time-of-flight method with a 46 MeV electron linear accelerator (linac) of the Research Reactor Institute, Kyoto University. A {sup 6}Li glass scintillator has been used as a neutron detector and metallic plates of Dy and Hf samples, 0.5 to 5.0 mm thick, have been applied to the neutron transmission measurement. The neutron flight path from the water-cooled Ta target to the {sup 6}Li glass scintillator is 22.1{+-}0.01 m. The background level has been determined by the block-off method and/or by using notch-filters of Co (132 eV), Ag (5.2 and 16.3 eV) and Mn (336 eV) a Cd sheet. The figures show the present measurements, the previous data and the evaluated data in ENDF/B-VI. (author)

  9. Nuclear translocation of Acinetobacter baumannii transposase induces DNA methylation of CpG regions in the promoters of E-cadherin gene.

    Directory of Open Access Journals (Sweden)

    Dong Chan Moon

    Full Text Available Nuclear targeting of bacterial proteins has emerged as a pathogenic mechanism whereby bacterial proteins induce host cell pathology. In this study, we examined nuclear targeting of Acinetobacter baumannii transposase (Tnp and subsequent epigenetic changes in host cells. Tnp of A. baumannii ATCC 17978 possesses nuclear localization signals (NLSs, (225RKRKRK(230. Transient expression of A. baumannii Tnp fused with green fluorescent protein (GFP resulted in the nuclear localization of these proteins in COS-7 cells, whereas the truncated Tnp without NLSs fused with GFP were exclusively localized in the cytoplasm. A. baumannii Tnp was found in outer membrane vesicles, which delivered this protein to the nucleus of host cells. Nuclear expression of A. baumannii Tnp fused with GFP in A549 cells induced DNA methylation of CpG regions in the promoters of E-cadherin (CDH1 gene, whereas the cytoplasmic localization of the truncated Tnp without NLSs fused with GFP did not induce DNA methylation. DNA methylation in the promoters of E-cadherin gene induced by nuclear targeting of A. baumannii Tnp resulted in down-regulation of gene expression. In conclusion, our data show that nuclear traffic of A. baumannii Tnp induces DNA methylation of CpG regions in the promoters of E-cadherin gene, which subsequently down-regulates gene expression. This study provides a new insight into the epigenetic control of host genes by bacterial proteins.

  10. Thermodynamic structure of the marine atmosphere over the region 80-87°E along 13°N during August (phase II) BOBMEX-99

    Indian Academy of Sciences (India)

    Savita B Morwal; P Seetaramayya

    2003-06-01

    Thermodynamic structure of the marine atmosphere in the region between 80 and 87°E along 13°N over the Bay of Bengal was studied using 13 high resolution radiosonde profiles from surface −400 hPa collected onboard ORV Sagar Kanya during the period 27th-30th August, during BOBMEX-99. Saturation point concept, mixing line analysis and conserved variable diagrams have been used to identify boundary layer characteristics such as air mass movement and stability of the atmosphere. The results showed relatively dry air near the ocean surface between 1000 and 950 hPa. This feature is confirmed by the conserved v structure in this layer. Further, v seldom showed any inversions in this region. The e and es profiles showed persistent low cloud layers between 900 and 700 hPa. The conserved variable diagrams (e-q) showed the existence of double mixing line structures approximately at 950 and 700 hPa levels.

  11. First simultaneous lidar observations of sodium layers and VHF radar observations of E-region field-aligned irregularities at the low-latitude station Gadanki

    Directory of Open Access Journals (Sweden)

    S. Sridharan

    2009-09-01

    Full Text Available Simultaneous observations of atmospheric sodium (Na made by a resonance lidar and E-region field-aligned-irregularities (FAI made by the Indian MST radar, both located at Gadanki (13.5° N, 79.2° E and horizontal winds acquired by a SKiYMET meteor radar at Trivandrum (8.5° N, 77° E are used to investigate the relationship among sodium layer, FAI and neutral winds in the mesosphere and lower thermosphere region. The altitudes and descent rates of higher altitude (~95 km Na layer and FAI agree quite well. The descending structures of the higher altitude Na layer and FAI are found to be closely related to the diurnal tidal phase structure in zonal winds observed over Trivandrum. At lower altitudes, the descent rate of FAI is larger than that of Na layer and zonal tidal phase. These observations support the hypothesis that the metallic ion layers are formed by the zonal wind shear associated with tidal winds and subsequently get neutralized to manifest in the form of descending Na layers. The descending FAI echoing layers are manifestation of the instabilities setting in on the ionization layer. In the present observations, the altitudes of occurrence of Na layer and FAI echoes being low, we surmise that it is quite possible that the FAI echoes are due to the descent of already formed irregularities at higher altitudes.

  12. A arquitetura e o planejamento urbano-regional emface do processo de mundialização

    Directory of Open Access Journals (Sweden)

    Alessandro Ventura

    2003-01-01

    Full Text Available 1. Main characteristics of the current process ofglobalization; instability created by the formation ofthe global society; changes in the relations of space-time in architecture and urbanism; 2. The physical planning in the face of changes;contributions of four Chartes – Atenas, LaTourrette, Andes and UIA / Beijing-, of geographersand economists for the field of regional planning andarchitecture; the current changes and theirconsequences in the process of physical planning; 3. The modular production in the globalization; timeof construction of buildings in view of thetransformations; the immobility submits thebuilding to its urban context; the mobility in theconstruction process of buildings is fundamental fornew configurations of the city; 4. The environmental factors in the process of lobalization and the introduction of safeguards ofterritorial character; the scattering of activities and theconsequent conversion of the local in a commonplace;the global architecture and its foreign elementsdisrespect cultural and environmental values; 5. Preservation of human dimension and theincreased value of the local must give an outstandingplace to the social sector and guarantee the ways forthe development of architecture and planning.

  13. Ground-based measurements of the vertical E-field in mountainous regions and the "Austausch" effect

    Science.gov (United States)

    Yaniv, Roy; Yair, Yoav; Price, Colin; Mkrtchyan, Hripsime; Lynn, Barry; Reymers, Artur

    2017-06-01

    Past measurements of the atmospheric vertical electric field (Ez or potential gradient) at numerous land stations showed a strong response of the daily electric field to a morning local effect known as ;Austausch; - the transport of electrical charges due to increased turbulence. In mountainous regions, nocturnal charge accumulation, followed by an attachment process to aerosols near the surface in valleys, known as the electrode effect, is lifted as a charged aerosol layer by anabatic (upslope) winds during the morning hours due to solar heating. Ground-based measurements during fair weather days were conducted at three mountain stations in Israel and Armenia. We present results of the mean diurnal variation of Ez and make comparisons with the well-known Carnegie curve and with past measurements of Ez on mountains. We report a good agreement between the mean diurnal curves of Ez at various mountain stations and the time of local sunrise when the Ez is found to increase. We attribute this morning maximum to the Austausch (or exchange) layer effect. We support our findings with conduction and turbulent current measurements showing high values of ions and charged aerosols being transported by winds from morning to noon local time, and by model simulations showing the convergence of winds in the early morning hours toward the mountain peak.

  14. Human papillomavirus type 16 variant analysis of E6, E7, and L1 [corrected] genes and long control region in [corrected] cervical carcinomas in patients in northeast China.

    Science.gov (United States)

    Shang, Qinglong; Wang, Yan; Fang, Yong; Wei, Lanlan; Chen, Sijia; Sun, Yuhui; Li, Baoxin; Zhang, Fengmin; Gu, Hongxi

    2011-07-01

    Human papillomavirus type 16 (HPV 16) plays a cardinal role in the pathogenesis of cervical cancer. HPV 16 has intratypic variants which show different geographical distributions and different oncogenic potentials. To analyze the presence of sequence variations of HPV 16 variants in northeast China, 71 cervical carcinomas were identified by HPV typing. HPV 16-positive specimens were analyzed by PCR-directed sequencing in the E6, E7, and L1 genes and the LCR (long control region). The variation data were compared with those of neighboring districts. In this hospital-based study, HPV 16 was the most common type (73.24%). In HPV 16-positive specimens, 67.31% belonged to the European (E) lineage, while 32.69% were Asian (As) variants. The Asian-American (AA), African-1 (Af-1), African-2 (Af-2), and northern American (NA) lineages were not detected. The most frequently observed variation sites were T178G (32.69%) in E6; A647G (34.62%), G666A (38.46%), and T846C (32.69%) in E7; C6826T (36.17%) and G7060A (61.70%) in L1; and G7521A (98.08%) in the LCR. The most prevalent amino acid variations were D25E in E6 and N29S in E7. In addition, 28 novel variations of HPV 16 were reported. Some covariations between different genes were obtained. In this study, HPV 16 variants belonged to the European lineage and the Asian lineage. Compared with neighboring districts, the distribution of HPV 16 variants in northeast China had a typical pattern. As the first report on HPV 16 variants in northeast China, it should be helpful for designing a HPV vaccine and HPV vaccination program in China.

  15. Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.

    Science.gov (United States)

    Rasti, Mozhgan; Grand, Roger J A; Mymryk, Joe S; Gallimore, Phillip H; Turnell, Andrew S

    2005-05-01

    The N-terminal region of the adenovirus (Ad) 12S E1A gene product targets several cellular proteins that are essential for the induction of S phase, cellular immortalization, cellular transformation, transcriptional repression, and transcriptional activation. The precise binding sites for these proteins, however, remain to be resolved. We therefore undertook an extensive site-directed mutagenesis approach to generate specific point mutants and to precisely map the binding sites for CBP, p300, TATA-binding protein (TBP), S4, S8, hGcn5, P/CAF, and Ran within the first 30 amino acids of the Ad5 12S E1A protein. We determined that although common residues within the N-terminal region can form partial binding sites for these proteins, point mutants were also generated that could discriminate between binding sites. These data indicate that AdE1A can target each of these proteins individually through distinct binding sites. It was evident, however, that the mutation of specific hydrophobic residues typically had the greatest effect upon AdE1A's ability to bind individual partners. Indeed, the mutation of L at positions 19 and 20 eliminated the ability of AdE1A to interact with any of the N-terminal binding proteins studied here. Interestingly, although TBP and S8 or CBP/p300 can exist as functional complexes, RNA interference revealed that the recruitment of either TBP, S8, or CBP/p300 to AdE1A was not dependent upon the expression of the other proteins. These data further indicate that AdE1A can target individual partner proteins in vivo and that it does not necessarily recruit these proteins indirectly as components of larger macromolecular complexes. Finally, we took advantage of the fine-mapping data to ascertain which proteins were targeted during the transformation process. Consistent with previous studies, CBP/p300 was found to be targeted by AdE1A during this process, although our data suggest that binding to other N-terminal proteins is also important for

  16. Mapping contacts of the S12-S7 intercistronic region of str operon mRNA with ribosomal protein S7 of E. coli.

    Science.gov (United States)

    Golovin, Andrey; Spiridonova, Vera; Kopylov, Alexei

    2006-10-30

    In E. coli, S7 initiates 30S ribosome assembly by binding to 16S rRNA. It also regulates translation of the S12 and S7 cistrons of the 'streptomycin' operon transcript by binding to the S12-S7 intercistronic region. Here, we describe the contacts of N-terminally His(6)-tagged S7 with this region as mapped by UV-induced cross-linking. The cross-links are located at U(-34), U(-35), quite distant from the start codons of the two cistrons. In order to explain the mechanism of translational repression of S12-S7, we consider a possible conformational rearrangement of the intercistronic RNA structure induced by S7 binding.

  17. Analysis of Factors Affecting on Risk Management of Wheat Production Among Wheat Farmers (Razavieh Region, Khorasan-E-Razavi Province, Iran

    Directory of Open Access Journals (Sweden)

    V. Sarani

    2011-12-01

    Full Text Available The main purpose of this study was to analyze the Factors Affecting on risk management in wheat production among farmers of Razavieh region (Khorasan-E-Razavi province, Iran. Statistical population of the study was 1520 farmers that they had water cultivation. By using of stratified proportional random sampling 156 respondents were selected from 8 villages. For the calculation of the risk-aversion coefficient degree among farmers, the Safety First Rule model was used. The findings revealed that the dominant respondents (65% were risk-averse. The results of exploratory factorial analysis showed that five factors determined about 74.267 % from total variance for wheat farmers' risk management that consist of: economy & marketing management factor, planting management factor, harvest management factor, infrastructure management of farming and risk-sharing management factor. From among of the above mentioned factors, the most important factor of risk management in study region was factor of economy & marketing management

  18. A experiência da integração europeia e seu potencial para a integração regional The experience of european integration and its potential for regional integration

    Directory of Open Access Journals (Sweden)

    Philippe C. Schmitter

    2010-01-01

    Full Text Available O artigo mostra que o processo de constituição da União Europeia representa um caminho significativo para o reforço do regionalismo. Assim, pode tornar-se modelo para outras tentativas políticas de integração regional. A reflexão sobre as diversas teorias que explicam esse fenômeno é a estratégia mais eficaz para examinar as possibilidades de transferência dessa experiência. O autor constrói um quadro classificatório que permite a avaliação dos pontos fortes e os mais débeis presentes nas diferentes propostas. O desafio que se coloca à análise é o de compreender a mudança na relação entre Estados nacionais previamente soberanos e economias nacionais cada vez mais interdependentes.This paper shows that the process of constitution of the European Union represents a significant way of reinforcing regionalism. It can thus become a model for other political attempts at regional integration. A reflection on the various theories that account for this phenomenon is the best strategy to study the transposition of the European experience. The autor constructs a classification scheme that allows for the evaluation of the stronger and weaker points of the different approaches. The challenge is to understand the change in the relation among previously sovereign nation states and increasingly interdependent national economies.

  19. Probing the extent of the non-thermal emission from the Vela X region at TeV energies with H.E.S.S.

    Science.gov (United States)

    Abramowski, A.; Acero, F.; Aharonian, F.; Akhperjanian, A. G.; Anton, G.; Balenderan, S.; Balzer, A.; Barnacka, A.; Becherini, Y.; Becker Tjus, J.; Bernlöhr, K.; Birsin, E.; Biteau, J.; Bochow, A.; Boisson, C.; Bolmont, J.; Bordas, P.; Brucker, J.; Brun, F.; Brun, P.; Bulik, T.; Carrigan, S.; Casanova, S.; Cerruti, M.; Chadwick, P. M.; Charbonnier, A.; Chaves, R. C. G.; Cheesebrough, A.; Cologna, G.; Conrad, J.; Couturier, C.; Dalton, M.; Daniel, M. K.; Davids, I. D.; Degrange, B.; Deil, C.; deWilt, P.; Dickinson, H. J.; Djannati-Ataï, A.; Domainko, W.; Drury, L. O.' C.; Dubois, F.; Dubus, G.; Dutson, K.; Dyks, J.; Dyrda, M.; Egberts, K.; Eger, P.; Espigat, P.; Fallon, L.; Farnier, C.; Fegan, S.; Feinstein, F.; Fernandes, M. V.; Fernandez, D.; Fiasson, A.; Fontaine, G.; Förster, A.; Füßling, M.; Gajdus, M.; Gallant, Y. A.; Garrigoux, T.; Gast, H.; Giebels, B.; Glicenstein, J. F.; Glück, B.; Göring, D.; Grondin, M.-H.; Häffner, S.; Hague, J. D.; Hahn, J.; Hampf, D.; Harris, J.; Heinz, S.; Heinzelmann, G.; Henri, G.; Hermann, G.; Hillert, A.; Hinton, J. A.; Hofmann, W.; Hofverberg, P.; Holler, M.; Horns, D.; Jacholkowska, A.; Jahn, C.; Jamrozy, M.; Jung, I.; Kastendieck, M. A.; Katarzyński, K.; Katz, U.; Kaufmann, S.; Khélifi, B.; Klochkov, D.; Kluźniak, W.; Kneiske, T.; Komin, Nu.; Kosack, K.; Kossakowski, R.; Krayzel, F.; Krüger, P. P.; Laffon, H.; Lamanna, G.; Lenain, J.-P.; Lennarz, D.; Lohse, T.; Lopatin, A.; Lu, C.-C.; Marandon, V.; Marcowith, A.; Masbou, J.; Maurin, G.; Maxted, N.; Mayer, M.; McComb, T. J. L.; Medina, M. C.; Méhault, J.; Menzler, U.; Moderski, R.; Mohamed, M.; Moulin, E.; Naumann, C. L.; Naumann-Godo, M.; de Naurois, M.; Nedbal, D.; Nguyen, N.; Niemiec, J.; Nolan, S. J.; Ohm, S.; de Oña Wilhelmi, E.; Opitz, B.; Ostrowski, M.; Oya, I.; Panter, M.; Parsons, D.; Paz Arribas, M.; Pekeur, N. W.; Pelletier, G.; Perez, J.; Petrucci, P.-O.; Peyaud, B.; Pita, S.; Pühlhofer, G.; Punch, M.; Quirrenbach, A.; Raue, M.; Reimer, A.; Reimer, O.; Renaud, M.; de los Reyes, R.; Rieger, F.; Ripken, J.; Rob, L.; Rosier-Lees, S.; Rowell, G.; Rudak, B.; Rulten, C. B.; Sahakian, V.; Sanchez, D. A.; Santangelo, A.; Schlickeiser, R.; Schulz, A.; Schwanke, U.; Schwarzburg, S.; Schwemmer, S.; Sheidaei, F.; Skilton, J. L.; Sol, H.; Spengler, G.; Stawarz, Ł.; Steenkamp, R.; Stegmann, C.; Stinzing, F.; Stycz, K.; Sushch, I.; Szostek, A.; Tavernet, J.-P.; Terrier, R.; Tluczykont, M.; Trichard, C.; Valerius, K.; van Eldik, C.; Vasileiadis, G.; Venter, C.; Viana, A.; Vincent, P.; Völk, H. J.; Volpe, F.; Vorobiov, S.; Vorster, M.; Wagner, S. J.; Ward, M.; White, R.; Wierzcholska, A.; Wouters, D.; Zacharias, M.; Zajczyk, A.; Zdziarski, A. A.; Zech, A.; Zechlin, H.-S.

    2012-12-01

    Context. Vela X is a region of extended radio emission in the western part of the Vela constellation: one of the nearest pulsar wind nebulae, and associated with the energetic Vela pulsar (PSR B0833-45). Extended very-high-energy (VHE) γ-ray emission (HESS J0835-455) was discovered using the H.E.S.S. experiment in 2004. The VHE γ-ray emission was found to be coincident with a region of X-ray emission discovered with ROSAT above 1.5 keV (the so-called Vela X cocoon): a filamentary structure extending southwest from the pulsar to the centre of Vela X. Aims: A deeper observation of the entire Vela X nebula region, also including larger offsets from the cocoon, has been performed with H.E.S.S. This re-observation was carried out in order to probe the extent of the non-thermal emission from the Vela X region at TeV energies and to investigate its spectral properties. Methods: To increase the sensitivity to the faint γ-ray emission from the very extended Vela X region, a multivariate analysis method combining three complementary reconstruction techniques of Cherenkov-shower images is applied for the selection of γ-ray events. The analysis is performed with the On/Off background method, which estimates the background from separate observations pointing away from Vela X; towards regions free of γ-ray sources but with comparable observation conditions. Results: The γ-ray surface brightness over the large Vela X region reveals that the detection of non-thermal VHE γ-ray emission from the PWN HESS J0835-455 is statistically significant over a region of radius 1.2° around the position α = 08h35m00s, δ = -45°36'00'' (J2000). The Vela X region exhibits almost uniform γ-ray spectra over its full extent: the differential energy spectrum can be described by a power-law function with a hard spectral index Γ = 1.32 ± 0.06stat ± 0.12sys and an exponential cutoff at an energy of (14.0 ± 1.6stat ± 2.6sys) TeV. Compared to the previous H.E.S.S. observations of Vela X the

  20. Occurrence of Sporadic -E layer during the Ending Phase of Solar Cycle 23rd and Rising Phase of Solar Cycle 24th over the Anomaly Crest Region Bhopal

    Science.gov (United States)

    Bhawre, Purushottam; Gwal, Ashok Kumar; Tripathi, Sharad Chandra; Mansoori, Azad Ahmad; Aslam A., M.; Khan, Parvaiz A.; Purohit, Pramod K.; Waheed, Malik Abdul; Khatarkar, Prakash

    Ionospheric anomaly crest regions are most challenging for scientific community to understand its mechanism and investigation, for this purpose we are investigating some inospheric result for this region. The study is based on the ionogram data recorded by IPS-71 Digital Ionosonde installed over anomaly crust region Bhopal (Geo.Lat.23.2° N, Geo. Long77.4° E, Dip latitude18.4°) over a four year period from January 2007 to December 2010, covering the ending phase of 23rd Solar Cycle and starting phase of 24th solar cycle. This particular period is felt to be very suitable for examining the sunspot number and it encompasses periods of low solar activities. Quarterly ionograms are analyzed for 24 hours during these study years and have been carefully examined to note down the presence of sporadic- E. We also note down the space weather activities along with the study. The studies are divided in mainly four parts with space and geomagnetic activities during these periods. The occurrence probability of this layer is highest in summer solstice, moderate during equinox and low during winter solstice. Remarkable occurrence peaks appear from June to July in summer and from December to January in winter. The layer occurrence showed a double peak variation with distinct layer groups, in the morning (0200 LT) and the other during evening (1800 LT).The morning layer descent was associated with layer density increase indicating the strengthening of the layer while it decreased during the evening layer descent. The result indicates the presence of semi-diurnal tide over the location while the higher descent velocities could be due to the modulation of the ionization by gravity waves along with the tides. The irregularities associated with the gradient-drift instability disappear during the counter electrojet and the current flow is reversed in westward. Keyword: ionosphere, solar cycle, sporadic - E

  1. Study on E - Commerce Development Strategy of Regional Retail Business%区域性零售企业电子商务发展策略研究

    Institute of Scientific and Technical Information of China (English)

    韩海林; 刘希玉

    2012-01-01

    电子商务作为一种新型经济形态,正在全球范围内以前所未有的速度迅猛发展,已经成为引领生产生活方式变革的重要推动力。但是,我国区域性零售企业电子商务发展仍处于探索阶段,目前尚无成功的商业模式和发展策略。文章结合零售业的商业模式,通过数据及实证研究,分析了区域性零售企业发展电子商务应采取的商业模式及发展策略,旨在探索具有中国特色的区域性零售企业电子商务发展之路。%As a new economic form, e -commerce makes rapid progress in an unprecedented speed in the world. It has become an important driving force to lead the reform of producing and life style. However, the region- al retail business of China just steps in the exploratory stage, and there are no successful business models and de- velopment strategy at present. Based on the business models of retail industry, the paper analyzes the business models and developing stratagems that regional retail enterprises should adopt to develop e -commerce through de- tailed data and demonstration, and is to seek the developing way that regional retail enterprises develop e - com- merce with Chinese characteristics.

  2. Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation.

    Directory of Open Access Journals (Sweden)

    Derek M Murphy

    Full Text Available BACKGROUND: Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most important prognostic indicator of poor clinical outcome in this disease is genomic amplification of MYCN, a member of a family of oncogenic transcription factors. METHODOLOGY: We applied MYCN chromatin immunoprecipitation to microarrays (ChIP-chip using MYCN amplified/non-amplified cell lines as well as a conditional knockdown cell line to determine the distribution of MYCN binding sites within all annotated promoter regions. CONCLUSION: Assessment of E-box usage within consistently positive MYCN binding sites revealed a predominance for the CATGTG motif (p<0.0016, with significant enrichment of additional motifs CATTTG, CATCTG, CAACTG in the MYCN amplified state. For cell lines over-expressing MYCN, gene ontology analysis revealed enrichment for the binding of MYCN at promoter regions of numerous molecular functional groups including DNA helicases and mRNA transcriptional regulation. In order to evaluate MYCN binding with respect to other genomic features, we determined the methylation status of all annotated CpG islands and promoter sequences using methylated DNA immunoprecipitation (MeDIP. The integration of MYCN ChIP-chip and MeDIP data revealed a highly significant positive correlation between MYCN binding and DNA hypermethylation. This association was also detected in regions of hemizygous loss, indicating that the observed association occurs on the same homologue. In summary, these findings suggest that MYCN binding occurs more commonly at CATGTG as opposed to the classic CACGTG E-box motif, and that disease associated over expression of MYCN leads to aberrant binding to additional weaker affinity E-box motifs in neuroblastoma. The co-localization of MYCN binding and DNA hypermethylation further supports the dual role of MYCN, namely that of a classical transcription

  3. Global MYCN transcription factor binding analysis in neuroblastoma reveals association with distinct E-box motifs and regions of DNA hypermethylation.

    LENUS (Irish Health Repository)

    Murphy, Derek M

    2009-01-01

    BACKGROUND: Neuroblastoma, a cancer derived from precursor cells of the sympathetic nervous system, is a major cause of childhood cancer related deaths. The single most important prognostic indicator of poor clinical outcome in this disease is genomic amplification of MYCN, a member of a family of oncogenic transcription factors. METHODOLOGY: We applied MYCN chromatin immunoprecipitation to microarrays (ChIP-chip) using MYCN amplified\\/non-amplified cell lines as well as a conditional knockdown cell line to determine the distribution of MYCN binding sites within all annotated promoter regions. CONCLUSION: Assessment of E-box usage within consistently positive MYCN binding sites revealed a predominance for the CATGTG motif (p<0.0016), with significant enrichment of additional motifs CATTTG, CATCTG, CAACTG in the MYCN amplified state. For cell lines over-expressing MYCN, gene ontology analysis revealed enrichment for the binding of MYCN at promoter regions of numerous molecular functional groups including DNA helicases and mRNA transcriptional regulation. In order to evaluate MYCN binding with respect to other genomic features, we determined the methylation status of all annotated CpG islands and promoter sequences using methylated DNA immunoprecipitation (MeDIP). The integration of MYCN ChIP-chip and MeDIP data revealed a highly significant positive correlation between MYCN binding and DNA hypermethylation. This association was also detected in regions of hemizygous loss, indicating that the observed association occurs on the same homologue. In summary, these findings suggest that MYCN binding occurs more commonly at CATGTG as opposed to the classic CACGTG E-box motif, and that disease associated over expression of MYCN leads to aberrant binding to additional weaker affinity E-box motifs in neuroblastoma. The co-localization of MYCN binding and DNA hypermethylation further supports the dual role of MYCN, namely that of a classical transcription factor affecting the

  4. Regional differences associated with drinking and driving in Brazil Diferenças regionais entre os fatores associados ao beber e dirigir no Brasil

    Directory of Open Access Journals (Sweden)

    Raquel De Boni

    2012-10-01

    Full Text Available OBJECTIVE: To evaluate regional differences and similarities associated with drinking and driving (DUI in the five Brazilian macro-regions. METHOD: A roadside survey was conducted in the 27 Brazilian state capitals. A total of 3,398 drivers were randomly selected and given a structured interview and a breathalyzer test. To determine the predictors of positive blood alcohol concentration (BAC in each region, a MANOVA was performed, and 3 groups were used as follows: 1 North and Northeast, 2 South and Midwest, and 3 Southeast. A Poisson robust regression model was performed to assess the variables associated with positive BAC in each group. RESULTS: Of all surveyed drivers, 2,410 had consumed alcohol in the previous 12 months. Most were male, with a median age of 36. Leisure as the reason for travel was associated with positive BAC in all 3 groups. Low schooling, being older than 30, driving cars or motorcycles and having been given a breathalyzer test at least once in their lives predicted DUI in at least two different groups. CONCLUSIONS: Factors , especially low schooling and leisure as a reason for travel, associated with drinking and driving were similar among regions, although certain region-specific features were observed. This information is important for aiming to reduce DUI in the country.OBJETIVO: Avaliar diferenças e similaridades em relação a beber e dirigir (DUI nas cinco macroregiões brasileiras. MÉTODO: Um roadside survey foi realizado nas 27 capitais brasileiras. Foram selecionados aleatoriamente 3.398 condutores que responderam a uma entrevista estruturada e foram testados com uso de etilômetro. Para a construção de modelos preditivos de alcoolemia positiva (BAC, as regiões foram agrupadas de acordo com sua similaridade, obtida por MANOVA, em: 1 Norte e Nordeste; 2 Sul e Centro-Oeste; 3 Sudeste. Em cada grupo foi realizado um modelo de regressão robusta para estimar as variáveis associadas a BAC. RESULTADOS: Dentre os

  5. Regional assessment of concentrations and sources of pharmaceutically active compounds, pesticides, nitrate, and E. coli in post-glacial aquifer environments (Canada).

    Science.gov (United States)

    Saby, Marion; Larocque, Marie; Pinti, Daniele L; Barbecot, Florent; Gagné, Sylvain; Barnetche, Diogo; Cabana, Hubert

    2017-02-01

    There is growing concern worldwide about the exposure of groundwater resources to pharmaceutically active compounds (PhACs) and agricultural contaminants, such as pesticides, nitrate, and Escherichia coli. For regions with a low population density and an abundance of water, regional contamination assessments are not carried out systematically due to the typically low concentrations and high costs of analyses. The objectives of this study were to evaluate regional-scale contaminant distributions in untreated groundwater in a rural region of Quebec (Canada). The geological and hydrogeological settings of this region are typical of post-glacial regions around the world, where groundwater flow can be complex due to heterogeneous geological conditions. A new spatially distributed Anthropogenic Footprint Index (AFI), based on land use data, was developed to assess surface pollution risks. The Hydrogeochemical Vulnerability Index (HVI) was computed to estimate aquifer vulnerability. Nine wells had detectable concentrations of one to four of the 13 tested PhACs, with a maximum concentration of 116ng·L(-1) for benzafibrate. A total of 34 of the 47 tested pesticides were detected in concentrations equal to or greater than the detection limit, with a maximum total pesticide concentration of 692ng·L(-1). Nitrate concentrations exceeded 1mg·L(-1) N-NO3 in 15.3% of the wells, and the Canadian drinking water standard was exceeded in one well. Overall, 13.5% of the samples had detectable E. coli. Including regional-scale sources of pollutants to the assessment of aquifer vulnerability with the AFI did not lead to the identification of contaminated wells, due to the short groundwater flow paths between recharge and the sampled wells. Given the occurrence of contaminants, the public health concerns stemming from these new data on regional-scale PhAC and pesticide concentrations, and the local flow conditions observed in post-glacial terrains, there is a clear need to investigate

  6. Acumulação de capital, mobilização regional do trabalho e coronelismo no Brasil

    Directory of Open Access Journals (Sweden)

    Ana Carolina Gonçalves Leite

    2014-01-01

    Full Text Available El artículo discute el carácter de las relaciones sociales de producción que reemplazaron la esclavitud en Brasil a partir de la segunda mitad del siglo XIX e investiga los mecanismos de subordinación del trabajo que permitieron la acumulación de capital en un contexto de amplia disponibilidad de tierras. Para ello, se analizan tesis marxianas sobre la formación de la superpoblación relativa y la génesis de la renta agraria, interpretando cómo el coronelismo posibilitó procesos regionales de movilización del trabajo en el país. Con ello, se observa que la existencia de formas de dominación, aparentemente personales, y de relaciones sociales de producción aparentemente no capitalistas, sobre todo en la formación del trabajo libre en Brasil, correspondía a la autonomización de las relaciones de capital y a una relativa superpoblación a nivel nacional.

  7. Neutral temperature and electron-density measurements in the lower E region by vertical HF sounding in the presence of an acoustic wave

    Science.gov (United States)

    Blanc, E.

    1982-04-01

    It is noted that an acoustic wave generated at ground level and propagating vertically through the lower ionosphere produces partial reflections of radio waves transmitted by a vertical sounder. The Doppler effect of the radio wave produced by the acoustic wave motion depends on the properties of the atmosphere and ionosphere. It is shown that this permits a determination of both the neutral-temperature and the electron-density profiles of the lower E region. The accuracy and the advantages offered by this method are discussed, and some experimental results are compared with those of other measurement techniques.

  8. Aplicación e información del derecho extranjero en el ámbito interamericano, regional y en el Uruguay

    Directory of Open Access Journals (Sweden)

    Eduardo Tellechea Bergman

    2014-03-01

    Full Text Available El actual incremento de las relaciones privadas internacionales consecuencia, entre otras variables, del desarrollo de los medios de comunicación internacional en sus distintas modalidades y de una paralela flexibilización de las fronteras nacionales, es determinante a nivel jurisdiccional del planteo de diversas cuestiones vinculadas a la aplicación e información del derecho extranjero, que el presente trabajo aborda en su regulación a nivel interamericano y regional, así como en el Derecho Internacional Privado uruguayo.

  9. Tabagismo no Brasil: desigualdades regionais e prevalência segundo características ocupacionais Tobacco smoking in Brazil: regional inequalities and prevalence according to occupational characteristics

    Directory of Open Access Journals (Sweden)

    Aluísio J. D. Barros

    2011-09-01

    Full Text Available O estudo descreveu a prevalência do tabagismo diário segundo sexo, idade, renda domiciliar e ocupação dos moradores de 15 anos ou mais, no Brasil e regiões, baseado nos dados da Pesquisa Nacional por Amostra Domiciliar 2008 (PNAD/IBGE. A análise considerou o desenho da amostra e incluiu 252.768 indivíduos. A prevalência de fumo diário no Brasil foi 15,1%, variando de 12,8% na região Norte a 17,4% na região Sul, sendo 62% maior nos homens que mulheres. A prevalência de fumo foi inversamente proporcional à renda domiciliar, sendo 18,6% entre os 20% mais pobres e 11,5% entre os 20% mais ricos. As mesmas tendências para sexo, idade e renda foram observadas nas diferentes regiões do país. O consumo diário de cigarros foi 3% maior entre os trabalhadores comparados com não trabalhadores. Trabalhadores não manuais apresentaram prevalências de fumo abaixo de 10%, enquanto trabalhadores manuais relataram frequências acima de 20%. A associação entre tabagismo e ocupação permaneceu após ajuste para sexo, idade e renda. As desigualdades encontradas devem ser consideradas no planejamento e direcionamento de ações efetivas para redução do tabagismo. Os grupos ocupacionais mais expostos deveriam ter prioridade nas intervenções.This study describes the prevalence of daily tobacco smoking according to sex, age, per capita household income and occupation of residents aged 15 years or more in Brazil and regions using data from the 2008 National Household Sample Survey (PNAD/IBGE. The analysis was adjusted for the sampling design and included 252.768 individuals. Daily smoking prevalence in Brazil was 15.1%, varying from 12.8% in the North region to 17.4% in the South region, and it was 62% higher in men compared to women. Smoking prevalence was inversely proportional to household income, 18.6% among the poorest 20% and 11.5% among the wealthiest 20%. The same trends for gender, age and income were observed in the different regions of

  10. BLACK SEA REGION AND RIGHT FLANK OF THE CAUCASUS LINE WITHIN FRAMEWORK OF ADMINISTRATIVE AND POLITICAL ACTIVITY OF E.A. GOLOVIN IN THE CAUCASUS (1838-1842

    Directory of Open Access Journals (Sweden)

    V. S. Kondusov

    2016-01-01

    Full Text Available In the article an attempt is made to characterise the military, administrative and political activity of General E.A. Golovin in the Black Sea Region and at the Right Flank of the Caucasus Line during the period of his administration of the region in 1838–1842. In the North-Western Caucasus E.A. Golovin had to solve several important issues one of which was fight against mountain dwellers’ raids against the Black Sea Border Line and Caucasus Line.The Black Sea Cossack Host was strengthened. They defeated the Circassians’ attacks more successfully, which is confirmed with the battle on January 23, 1842. On that day the Black Sea Cossacks under the command of lieutenant colonel Yaroshenko battered the group of mountain dwellers consisting of several thousands of people which was trying to attack the Vasyurinskiy Kuren Settlement. In the years of his administration of the Caucasus E.A. Golovin paid a lot of attention to improving the defensive capacity of villages of the Black Sea and Caucasus Line Cossack Hosts and provided for the Cossacks’ wealth. At the same time he had to coordinate the offensive actions from Kuban which the general did not support. However, within the framework of the existing bureaucratic system of military administration all he could do was play at the established rules and obey the ambitious borders chiefs. Peaceful initiatives had few chances under such circumstances. The author comes to the conclusion that E.A. Golovin assisted improvement of defence of the Russian borders, supported the flexible approach to solution of the Circassian issue, but peaceful initiatives had few chances owing to the existing military bureaucratic institutions and political framework.

  11. The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region.

    Science.gov (United States)

    Sutcliffe, J S; Jiang, Y H; Galijaard, R J; Matsuura, T; Fang, P; Kubota, T; Christian, S L; Bressler, J; Cattanach, B; Ledbetter, D H; Beaudet, A L

    1997-04-01

    Angelman syndrome (AS) and Prader-Willi syndrome (PWS) are distinct clinical phenotypes resulting from maternal and paternal deficiencies, respectively, in human chromosome 15qll-q13. Although several imprinted, paternally expressed transcripts have been identified within the PWS candidate region, no maternally expressed gene has yet been identified within the AS candidate region. We have developed an integrated physical map spanning the PWS and AS candidate regions and localized two breakpoints, including a cryptic t(14;15) translocation associated with AS and a non-AS 15q deletion, which substantially narrow the AS candidate region to approximately 250 kb. Mapping data indicate that the entire transcriptional unit of the E6-AP ubiquitin-protein ligase (UBE3A) gene lies within the AS region. The UBE3A locus expresses a transcript of approximately 5 kb at low to moderate levels in all tissues tested. The mouse homolog of UBE3A was cloned and sequenced revealing a high degree of conservation at nucleotide and protein levels. Northern and RT-PCR analysis of Ube3a expression in mouse tissues from animals with segmental, paternal uniparental disomy failed to detect substantially reduced or absent expression compared to control animals, failing to provide any evidence for maternal-specific expression from this locus. Recent identification of de novo truncating mutations in UBE3A taken with these observations indicates that mutations in UBE3A can lead to AS and suggests that this locus may encode both imprinted and biallelically expressed products.

  12. Elites modernas na transição para a periferia do capitalismo periférico Engenheiros, economistas e empresários mineiros e a percepção das relações entre o nacional e o regional no quadro da modernização econômica brasileira (1930-1970

    Directory of Open Access Journals (Sweden)

    Marcelo Magalhães Godoy

    2015-08-01

    Full Text Available RESUMOAs relações entre o nacional e o regional ganharam progressiva projeção entre as elites técnicas e empresariais de Minas Gerais no transcurso da modernização econômica brasileira (1930-1970. Desenvolveu-se compreensão crescentemente refinada dos fatores que presidiram a formação e reprodução dos desequilíbrios regionais e que responderam pelo atraso relativo da economia mineira. Em revistas de associação de classe (Associação Comercial de Minase Federação das Indústrias do Estado de Minas Gerais, de categoria profissional (Sociedade Mineira de Engenheiros e em revistas acadêmicas (Faculdade de Ciências Econômicas - UFMG, engenheiros, economistas e empresários apresentaram estudos e reflexões que contemplaram a demonstração do caráter desigual e concentrador do desenvolvimento brasileiro, a afirmação da crescente periferização da economia regional e a reivindicação da intervenção dos poderes públicos, estadual e federal, por meio de políticas que promovessem a interiorização do desenvolvimento e afirmassem a legitimidade de regionalismo corretivo das contradições da modernização econômica nacional.

  13. Polybrominated diphenyl ethers in air and fallouts from an e-waste polluted region in southeast China: insight into levels, compositional profiles, and seasonal variation.

    Science.gov (United States)

    Xu, Feng; Zhang, Gang; Wang, Junxia; Zhang, Wei; Liu, Lili; Lin, Kuangfei

    2015-12-01

    Air and fallout samples were collected seasonally in an e-waste polluted region in southeast of China in 2013-2014. The annual polybrominated diphenyl ethers (PBDEs) concentrations in air and fallout samples were 200 ± 162 pg m(-3) and 320 ± 255 ng g(-1), respectively. The deposition flux calculated from the fallout concentration was 110 ± 77.3 ng m(-2) day(-1). The PBDE levels and deposition fluxes of the samples deployed within the e-waste central area were three to four times higher than those in the surrounding area. The congener profiles in the air samples could be commonly found in commercial penta-BDE mixtures. BDE209 was the most dominant congener in fallout samples. Debromination processes were confirmed to occur both in the air and fallouts due to the minor amounts or inexistence of some congeners in technical PBDE products. The highest gaseous PBDE concentration was found during the summer while lowest during the autumn. PBDE concentration in fallouts turned up higher in the cold months while lower in the warm months. The similarity of deposition fluxes at sites in the e-waste central area indicated a steady PBDE emission source, whereas the significant relationship between deposition fluxes and particle weights at sites in the e-waste surrounding area suggested the scavenging of PBDEs in this area was largely associated with particles.

  14. 241 Am ( n ,γ) cross section in the neutron energy region between 0.02 eV and 300 keV

    Science.gov (United States)

    Jandel, M.; Bredeweg, T. A.; Bond, E. M.; Chadwick, M. B.; Clement, R. R.; Couture, A.; O'Donnell, J. M.; Haight, R. C.; Reifarth, R.; Rundberg, R. S.; Ullmann, J. L.; Vieira, D. J.; Wilhelmy, J. B.; Wouters, J. M.; Macri, R. A.; Wu, C. Y.; Becker, J. A.

    2008-04-01

    The Detector for Advanced Neutron Capture Experiments (DANCE) at Los Alamos National Laboratory (LANL) was used for a neutron capture cross section measurement on 241 Am . The high granularity of the DANCE array (160 BaF2 detectors in a 4π geometry) enables an efficient detection of prompt gamma rays following neutron capture. The preliminary results on the 241 Am ( n ,γ) cross section are presented from 0.02 eV to 300 keV. The cross section at thermal energy E n = 0.0253 eV was determined to be 665±33 barns. Resonance parameters were obtained using the SAMMY7 fit to the measured cross section in the resonance region. Significant discrepancies were found between our results and data evaluations for the first three lowest lying resonances. The cross section for neutrons with E n >l keV agrees well with the ENDF/B-VII.0 and JENDL-3.3 evaluations.

  15. Densidades do sistema financeiro: Uso corporativo e desigualdades regionais do território brasileiro / Financial system densities: the corporative use and regional inequalities of Brazilian territory

    Directory of Open Access Journals (Sweden)

    Ricardo Alberto Scherma

    2011-04-01

    Full Text Available Diante da histórica situação geográfica de desigualdade regional brasileira, procuramos destacar a questão da desigual distribuição do dinheiro, analisando tanto a instalação dos fixos e como a dinâmica dos fluxos do sistema financeiro em território nacional. Demonstramos a territorialização do sistema financeiro, por meio de suas agências bancárias, que controlam hoje a dinâmica dos fluxos monetários em território brasileiro. Contudo, apenas o conhecimento dessas formas geográficas, sua quantificação e topologia de nada nos adiantariam se não investigássemos os fluxos de crédito e de depósitos, revelando as desigualdades resultantes do uso corporativo do território brasileiro. Por último, levantamos dados e realizamos revisão bibliográfica que demonstra a consolidação da cidade de São Paulo como centro financeiro do território nacional.

  16. Internato regional e formação médica: percepção da primeira turma pós-reforma curricular

    Directory of Open Access Journals (Sweden)

    Danilo Garcia Ruiz

    Full Text Available As escolas médicas brasileiras priorizam o ambiente hospitalar para o ensino e acabam formando profissionais carentes de compromisso social. O curso de Medicina da Universidade Federal de Santa Maria implantou, em 2004, um novo currículo que inclui o Internato Regional (IR, em que o interno permanece dois meses em município conveniado, atuando em atenção primária em saúde. Este estudo transversal e quanti-qualitativo teve por objetivo conhecer a percepção dos acadêmicos da primeira turma que realizou o IR sobre o impacto desse modelo de estágio em sua formação, mediante a aplicação de um questionário semiestruturado. Mais de 75% das respostas apontaram ter havido contribuição para maior conhecimento da realidade social e profissional, aprimoramento da relação médico-paciente e desenvolvimento de autoconfiança no exercício da profissão. O principal ponto negativo ressaltado foi o despreparo dos médicos-preceptores para atuar como docentes. No atual contexto de mudanças, o IR surge como uma proposta satisfatória de ampliação dos cenários de prática-ensino-aprendizagem e contribui com a formação humana e pessoal dos futuros médicos, apesar de ainda carecer de preceptoria qualificada.

  17. SU-E-T-492: Influence of Clipping PTV in Build-Up Region On IMRT Plan Quality and Deliverability

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, S; Manigandan, D; Sahai, P; Biswas, A; Subramani, V; Chander, S; Julkha, P; Rath, G [Fortis Hospital, Mohali, Punjab (India)

    2015-06-15

    Purpose: To study the influence of clipping PTV from body contour on plan quality and deliverability in build-up region for superficial target. Methods: Five previously treated patients of post-operative carcinoma of parotid were re-planned for IMRT (6MV X-rays, sliding window technique, five fields and 60Gy/30 fractions) using eclipse treatment planning system (TPS) by keeping dose volume constraints and all other parameters constant, only PTV was clipped from body contour by 0mm, 1mm, 2mm and 3mm respectively. Planned fluence was transferred to previously scanned solid water phantom by placing I’matriXX array at 0.5cm depth (2mm slab+3mm inherent). Fluence was delivered by Varian CL2300C/D linac at 99.5cm source to detector distance. Measured fluence was compared with TPS dose plane using 2D gamma evaluation using 3%/3mm DTA criteria. Total MU (monitor unit) required to deliver a plan was also noted. For plan quality, PTV, maximum-dose, minimum-dose, coverage index (CI=PTV volume covered by prescription dose/PTV) and heterogeneity index HI=D5/D95 were analyzed using dose volume histogram (DVH). Results: The Result of gamma function analysis for I’matriXX and TPS were 97.63±1.79%, 97.48±0.99, 98.08±0.89% and 98.01±0.78% at 0.5cm build-up depth for 0, 1, 2 and 3mm PTV clipping, respectively. I’matriXX measured dose was higher compared to TPS. Total MU required for delivering a plan were 552±61, 503±47, 436±24 and 407±22. Maximum-dose to PTV was 6635.80±62.01cGy, 6635.80±40.60cGy, 6608.43±51.07cGy and 6564.20±28.51cGy. Similarly, minimum-dose to PTV was 3306.23±458.56cGy, 3546.57±721.01cGy, 4591.43±298.81cGy and 4861.90±412.40cGy. CI was 0.9347±0.020, 0.9398±0.021, 0.9448±0.022 and 0.9481±0.021. Similarly, HI was 1.089±0.015, 1.084±0.014, 1.078±0.009 and 1.074±0.008 for 0, 1, 2 and 3mm PTV clipping, respectively. Conclusion: Gamma function analysis resulted in almost similar results. However, I’matriXX was overestimating the dose

  18. Measurement of the Polarized Structure Function sigma {sub LT'} for (p{rvec e},e'p) pi{sup 0} in the Delta (1232) Resonance Region

    Energy Technology Data Exchange (ETDEWEB)

    Kyungseon Joo; L.C. Smith; V.D. Burkert; R. Minehart

    2003-05-01

    The polarized longitudinal-transverse structure function {sigma}{sub LT'} has been measured for the first time in the {Delta}(1232) resonance region at Q{sup 2} = 0.40 and 0.65 GeV{sup 2}. Data for the p{rvec e},e'p {pi}{sup 0} reaction were taken at Jefferson Lab with the CEBAF Large Acceptance Spectrometer (CLAS) using longitudinally polarized electrons at an energy of 1.515 GeV. Evidence for interference between resonant and non-resonant amplitudes is discussed using a partial wave analysis. Comparison with previous beam asymmetry measurements at MAMI indicate a deviation from the predicted Q{sup 2} dependence of {sigma}{sub LT'} using recent phenomenological models.

  19. First Measurement of the Angular Coefficients of Drell-Yan $e^{+}e^{-}$ pairs in the Z Mass Region from $p\\bar{p}$ Collisions at $\\sqrt{s}$ = 1.96 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; Aaltonen, T.; /Helsinki Inst. of Phys.; Alvarez Gonzalez, B.; /Oviedo U. /Cantabria Inst. of Phys.; Amerio, S.; /INFN, Padua; Amidei, D.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, A.; /Frascati; Antos, J.; /Comenius U.; Apollinari, G.; /Fermilab; Appel, J.A.; /Fermilab; Apresyan, A.; /Purdue U. /Waseda U. /Dubna, JINR

    2011-03-01

    We report on the first measurement of the angular distributions of final state electrons in p{bar p} {yields} {gamma}*/Z {yields} e{sup +}e{sup -} + X events produced in the Z boson mass region at {radical}s = 1.96 TeV. The data sample collected by the CDF II detector for this result corresponds to 2.1 fb{sup -1} of integrated luminosity. The angular distributions are studied as a function of the transverse momentum of the electron-positron pair and show good agreement with the Lam-Tung relation, consistent with a spin-1 description of the gluon, and demonstrate that at high values of the transverse momentum, Z bosons are produced via quark anti-quark annihilation and quark-gluon Compton processes.

  20. Measurement of $d\\sigma/dy$ of Drell-Yan $e^+e^-$ pairs in the $Z$ Mass Region from $p\\bar{p}$ Collisions at $\\sqrt{s}=1.96$ TeV

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, Timo Antero; /Helsinki Inst. of Phys.; Adelman, Jahred A.; /Chicago U., EFI; Gonzalez, Barbara Alvarez; /Cantabria Inst. of Phys.; Amerio, Silvia; /Padua U., CISAS; Amidei, Dante E.; /Michigan U. /INFN, Padua; Anastassov, Anton Iankov; /Northwestern U.; Annovi, Alberto; /Frascati; Antos, Jaroslav; /Comenius U.; Apollinari, Giorgio; /Fermilab; Appel, Jeffrey A.; /Fermilab; Apresyan, Artur; /Purdue U. /Waseda U.

    2010-03-01

    We report on a CDF measurement of the total cross section and rapidity distribution, d{sigma}/dy, for q{bar q} {yields} {gamma}{sup *}/Z {yields} e{sup +} e {sup -} events in the Z boson mass region (66 < M {sub ee} < 116 GeV/c {sub 2}) produced in p{bar p} collisions at {radical}s = 1.96 TeV with 2.1 fb{sup -1} of integrated luminosity. The measured cross section of 257 {+-} 16pb and d{sigma}/dy distribution are compared with Next-to-Leading-Order (NLO) and Next-to-Next-to-Leading-Order (NNLO) QCD theory predictions with CTEQ and MRST/MSTW parton distribution functions (PDFs). There is good agreement between the experimental total cross section and d{sigma}/dy measurements with theoretical calcualtion with the most recent NNLO PDFs.

  1. Measurement of d sigma/dy of Drell-Yan e+ e- pairs in the Z Mass Region from p anti-p Collisions at s88(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Adelman, J.; /Chicago U., EFI; Akimoto, T.; /Tsukuba U.; Alvarez Gonzalez, B.; /Cantabria Inst. of Phys.; Amerio, S.; /Padua U. /INFN, Padua; Amidei, D.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, A.; /Frascati; Antos, J.; /Comenius U.; Apollinari, G.; /Fermilab; Apresyan, A.; /Purdue U. /Waseda U.

    2009-08-01

    We report on a CDF measurement of the total cross section and rapidity distribution, d{sigma}/dy, for q{bar q} {yields} {gamma}*/Z {yields} e{sup +}e{sup -} events in the Z boson mass region (66 < M{sub ee} < 116 GeV/c{sup 2}) produced in p{bar p} collisions at {radical}s = 1.96 TeV with 2.1 fb{sup -1} of integrated luminosity. The measured cross section of 256 {+-} 16 pb and d{sigma}/dy distribution are compared with Next-to-Leading-Order and Next-to-Next-to-Leading-Order QCD theory predictions with CTEQ and MRST parton distribution functions (PDFs). There is good agreement between data and theory except at large rapidity for which further tuning of PDF models may be needed.

  2. Anomalous line shape of the cross section for e{+}e{-}--> hadrons in the center-of-mass energy region between 3.650 and 3.872 GeV.

    Science.gov (United States)

    Ablikim, M; Bai, J Z; Ban, Y; Cai, X; Chen, H F; Chen, H S; Chen, H X; Chen, J C; Chen, Jin; Chen, Y B; Chu, Y P; Dai, Y S; Diao, L Y; Deng, Z Y; Dong, Q F; Du, S X; Fang, J; Fang, S S; Fu, C D; Gao, C S; Gao, Y N; Gu, S D; Gu, Y T; Guo, Y N; He, K L; He, M; Heng, Y K; Hou, J; Hu, H M; Hu, J H; Hu, T; Huang, G S; Huang, X T; Ji, X B; Jiang, X S; Jiang, X Y; Jiao, J B; Jin, D P; Jin, S; Lai, Y F; Li, G; Li, H B; Li, J; Li, R Y; Li, S M; Li, W D; Li, W G; Li, X L; Li, X N; Li, X Q; Liang, Y F; Liao, H B; Liu, B J; Liu, C X; Liu, F; Liu, Fang; Liu, H H; Liu, H M; Liu, J; Liu, J B; Liu, J P; Liu, Jian; Liu, Q; Liu, R G; Liu, Z A; Lou, Y C; Lu, F; Lu, G R; Lu, J G; Luo, C L; Ma, F C; Ma, H L; Ma, L L; Ma, Q M; Mao, Z P; Mo, X H; Nie, J; Ping, R G; Qi, N D; Qin, H; Qiu, J F; Ren, Z Y; Rong, G; Ruan, X D; Shan, L Y; Shang, L; Shen, D L; Shen, X Y; Sheng, H Y; Sun, H S; Sun, S S; Sun, Y Z; Sun, Z J; Tang, X; Tong, G L; Wang, D Y; Wang, L; Wang, L L; Wang, L S; Wang, M; Wang, P; Wang, P L; Wang, W F; Wang, Y F; Wang, Z; Wang, Z Y; Wang, Zheng; Wei, C L; Wei, D H; Weng, Y; Wu, N; Xia, X M; Xie, X X; Xu, G F; Xu, X P; Xu, Y; Yan, M L; Yang, H X; Yang, Y X; Ye, M H; Ye, Y X; Yu, G W; Yuan, C Z; Yuan, Y; Zang, S L; Zeng, Y; Zhang, B X; Zhang, B Y; Zhang, C C; Zhang, D H; Zhang, H Q; Zhang, H Y; Zhang, J W; Zhang, J Y; Zhang, S H; Zhang, X Y; Zhang, Yiyun; Zhang, Z X; Zhang, Z P; Zhao, D X; Zhao, J W; Zhao, M G; Zhao, P P; Zhao, W R; Zhao, Z G; Zheng, H Q; Zheng, J P; Zheng, Z P; Zhou, L; Zhu, K J; Zhu, Q M; Zhu, Y C; Zhu, Y S; Zhu, Z A; Zhuang, B A; Zhuang, X A; Zou, B S

    2008-09-05

    We observe an obvious anomalous line shape of the e;{+}e;{-}--> hadrons total cross sections in the energy region between 3.700 and 3.872 GeV. It is inconsistent with the explanation for only one simple psi(3770) resonance with a statistical significance of 7sigma. The anomalous line shape may be explained by two possible enhancements of the inclusive hadron production near the center-of-mass energies of 3.764 and 3.779 GeV, indicating that either there is likely a new structure in addition to the psi(3770) resonance around 3.773 GeV, or there are some physics effects reflecting the DD[over ] production dynamics.

  3. First measurement of the angular coefficients of Drell-Yan e(+)e(-) pairs in the Z mass region from pp¯ collisions at √s=1.96 TeV.

    Science.gov (United States)

    Aaltonen, T; González, B Alvarez; Amerio, S; Amidei, D; Anastassov, A; Annovi, A; Antos, J; Apollinari, G; Appel, J A; Apresyan, A; Arisawa, T; Artikov, A; Asaadi, J; Ashmanskas, W; Auerbach, B; Aurisano, A; Azfar, F; Badgett, W; Barbaro-Galtieri, A; Barnes, V E; Barnett, B A; Barria, P; Bartos, P; Bauce, M; Bauer, G; Bedeschi, F; Beecher, D; Behari, S; Bellettini, G; Bellinger, J; Benjamin, D; Beretvas, A; Bhatti, A; Binkley, M; Bisello, D; Bizjak, I; Bland, K R; Blumenfeld, B; Bocci, A; Bodek, A; Bortoletto, D; Boudreau, J; Boveia, A; Brau, B; Brigliadori, L; Brisuda, A; Bromberg, C; Brucken, E; Bucciantonio, M; Budagov, J; Budd, H S; Budd, S; Burkett, K; Busetto, G; Bussey, P; Buzatu, A; Calancha, C; Camarda, S; Campanelli, M; Campbell, M; Canelli, F; Canepa, A; Carls, B; Carlsmith, D; Carosi, R; Carrillo, S; Carron, S; Casal, B; Casarsa, M; Castro, A; Catastini, P; Cauz, D; Cavaliere, V; Cavalli-Sforza, M; Cerri, A; Cerrito, L; Chen, Y C; Chertok, M; Chiarelli, G; Chlachidze, G; Chlebana, F; Cho, K; Chokheli, D; Chou, J P; Chung, W H; Chung, Y S; Ciobanu, C I; Ciocci, M A; Clark, A; Compostella, G; Convery, M E; Conway, J; Corbo, M; Cordelli, M; Cox, C A; Cox, D J; Crescioli, F; Almenar, C Cuenca; Cuevas, J; Culbertson, R; Dagenhart, D; d'Ascenzo, N; Datta, M; de Barbaro, P; De Cecco, S; De Lorenzo, G; Dell'Orso, M; Deluca, C; Demortier, L; Deng, J; Deninno, M; Devoto, F; d'Errico, M; Di Canto, A; Di Ruzza, B; Dittmann, J R; D'Onofrio, M; Donati, S; Dong, P; Dorigo, M; Dorigo, T; Ebina, K; Elagin, A; Eppig, A; Erbacher, R; Errede, D; Errede, S; Ershaidat, N; Eusebi, R; Fang, H C; Farrington, S; Feindt, M; Fernandez, J P; Ferrazza, C; Field, R; Flanagan, G; Forrest, R; Frank, M J; Franklin, M; Freeman, J C; Funakoshi, Y; Furic, I; Gallinaro, M; Galyardt, J; Garcia, J E; Garfinkel, A F; Garosi, P; Gerberich, H; Gerchtein, E; Giagu, S; Giakoumopoulou, V; Giannetti, P; Gibson, K; Ginsburg, C M; Giokaris, N; Giromini, P; Giunta, M; Giurgiu, G; Glagolev, V; Glenzinski, D; Gold, M; Goldin, D; Goldschmidt, N; Golossanov, A; Gomez, G; Gomez-Ceballos, G; Goncharov, M; González, O; Gorelov, I; Goshaw, A T; Goulianos, K; Grinstein, S; Grosso-Pilcher, C; Group, R C; da Costa, J Guimaraes; Gunay-Unalan, Z; Haber, C; Hahn, S R; Halkiadakis, E; Hamaguchi, A; Han, J Y; Happacher, F; Hara, K; Hare, D; Hare, M; Harr, R F; Hatakeyama, K; Hays, C; Heck, M; Heinrich, J; Herndon, M; Hewamanage, S; Hidas, D; Hocker, A; Hopkins, W; Horn, D; Hou, S; Hughes, R E; Hurwitz, M; Husemann, U; Hussain, N; Hussein, M; Huston, J; Introzzi, G; Iori, M; Ivanov, A; James, E; Jang, D; Jayatilaka, B; Jeon, E J; Jha, M K; Jindariani, S; Johnson, W; Jones, M; Joo, K K; Jun, S Y; Junk, T R; Kamon, T; Karchin, P E; Kasmi, A; Kato, Y; Ketchum, W; Keung, J; Khotilovich, V; Kilminster, B; Kim, D H; Kim, H S; Kim, H W; Kim, J E; Kim, M J; Kim, S B; Kim, S H; Kim, Y K; Kimura, N; Kirby, M; Klimenko, S; Kondo, K; Kong, D J; Konigsberg, J; Kotwal, A V; Kreps, M; Kroll, J; Krop, D; Krumnack, N; Kruse, M; Krutelyov, V; Kuhr, T; Kurata, M; Kwang, S; Laasanen, A T; Lami, S; Lammel, S; Lancaster, M; Lander, R L; Lannon, K; Lath, A; Latino, G; LeCompte, T; Lee, E; Lee, H S; Lee, J S; Lee, S W; Leo, S; Leone, S; Lewis, J D; Limosani, A; Lin, C-J; Linacre, J; Lindgren, M; Lipeles, E; Lister, A; Litvintsev, D O; Liu, C; Liu, Q; Liu, T; Lockwitz, S; Lockyer, N S; Loginov, A; Lucchesi, D; Lueck, J; Lujan, P; Lukens, P; Lungu, G; Lys, J; Lysak, R; Madrak, R; Maeshima, K; Makhoul, K; Maksimovic, P; Malik, S; Manca, G; Manousakis-Katsikakis, A; Margaroli, F; Marino, C; Martínez, M; Martínez-Ballarín, R; Mastrandrea, P; Mathis, M; Mattson, M E; Mazzanti, P; McFarland, K S; McIntyre, P; McNulty, R; Mehta, A; Mehtala, P; Menzione, A; Mesropian, C; Miao, T; Mietlicki, D; Mitra, A; Miyake, H; Moed, S; Moggi, N; Mondragon, M N; Moon, C S; Moore, R; Morello, M J; Morlock, J; Movilla Fernandez, P; Mukherjee, A; Muller, Th; Murat, P; Mussini, M; Nachtman, J; Nagai, Y; Naganoma, J; Nakano, I; Napier, A; Nett, J; Neu, C; Neubauer, M S; Nielsen, J; Nodulman, L; Norniella, O; Nurse, E; Oakes, L; Oh, S H; Oh, Y D; Oksuzian, I; Okusawa, T; Orava, R; Ortolan, L; Griso, S Pagan; Pagliarone, C; Palencia, E; Papadimitriou, V; Paramonov, A A; Patrick, J; Pauletta, G; Paulini, M; Paus, C; Pellett, D E; Penzo, A; Phillips, T J; Piacentino, G; Pianori, E; Pilot, J; Pitts, K; Plager, C; Pondrom, L; Potamianos, K; Poukhov, O; Prokoshin, F; Pronko, A; Ptohos, F; Pueschel, E; Punzi, G; Pursley, J; Rahaman, A; Ramakrishnan, V; Ranjan, N; Redondo, I; Renton, P; Rescigno, M; Rimondi, F; Ristori, L; Robson, A; Rodrigo, T; Rodriguez, T; Rogers, E; Rolli, S; Roser, R; Rossi, M; Rubbo, F; Ruffini, F; Ruiz, A; Russ, J; Rusu, V; Safonov, A; Sakumoto, W K; Sakurai, Y; Santi, L; Sartori, L; Sato, K; Saveliev, V; Savoy-Navarro, A; Schlabach, P; Schmidt, A; Schmidt, E E; Schmidt, M P; Schmitt, M

    2011-06-17

    We report on the first measurement of the angular distributions of final state electrons in pp¯ → γ*/Z → e(+)e(-) + X events produced in the Z boson mass region at √s1.96 TeV. The data sample collected by the CDF II detector for this result corresponds to 2.1  fb(-1) of integrated luminosity. The angular distributions are studied as a function of the transverse momentum of the electron-positron pair and show good agreement with the Lam-Tung relation, consistent with a spin-1 description of the gluon, and demonstrate that, at high values of the transverse momentum, Z bosons are produced via quark-antiquark annihilation and quark-gluon Compton processes.

  4. Transverse momentum cross section of $e^+e^-$ pairs in the $Z$-boson region from $p\\bar{p}$ collisions at $\\sqrt{s}=1.96$ TeV

    CERN Document Server

    Aaltonen, T.

    2012-01-01

    The transverse momentum cross section of $e^+e^-$ pairs in the $Z$-boson mass region of 66-116 GeV/$c^2$ is precisely measured using Run II data corresponding to 2.1 fb$^{-1}$ of integrated luminosity recorded by the Collider Detector at Fermilab. The cross section is compared with quantum chromodynamic calculations. One is a fixed-order perturbative calculation at ${\\cal O}(\\alpha_s^2)$, and the other combines perturbative predictions at high transverse momentum with the gluon resummation formalism at low transverse momentum. Comparisons of the measurement with calculations show reasonable agreement. The measurement is of sufficient precision to allow refinements in the understanding of the transverse momentum distribution.

  5. Reflection imaging of the Moho and the aseismic Nazca slab in the Malargüe region with global-phase seismic interferometry

    Science.gov (United States)

    Draganov, D.; Nishitsuji, Y.; Ruigrok, E.; Gomez, M.; Wapenaar, C. P. A.

    2015-12-01

    A number of passive seismic methods have been developed over many decades. Still, imaging of aseismical zones of the subducting slabs is one of challenging themes in the geoscience community. Conventional seismological approaches, such as hypocentral mapping, receiver functions, and global tomography, have been providing useful imaging of the Nazca slab, which subducts under the South American plate; however, the aseismic zones remained unclear. Here, we propose to apply global-phase seismic interferometry (GloPSI) for the imaging of the aseismic zones of the Nazca slab beneath the Malargüe region (Mendoza, Argentina). GloPSI uses global phases (epicentral distances ≥ 120°) such as PKP, PKiKP, and PKIKP, recorded on the vertical component of the seismic sensors. These phases illuminate the lithosphere below the receivers with small angles of incidence, which illumination suffices for creating virtual sources that radiate primarily downwards. We then migrate the retrieved virtual responses to obtain a subsurface reflection image with high resolution (< 15 km in depth). We use data recorded in the Malargüe region using an exploration-type receiver array called MalARRgue. This array was recording continuously in 2012 for one year. In this presentation, we show the imaging results from the Moho down to the aseismic Nazca slab, including the upper mantle.

  6. Energy model in regional energy system; Modello computazionale dei flussi di enegia, massa e materia in un sistema energetico regionale per la valutazione delle emissioni

    Energy Technology Data Exchange (ETDEWEB)

    Mura, P.G.; Baccoli, R.; Carlini, U.; Innamorati, R.; Mariotti, S. [Cagliari Univ., Cagliari (Italy). Sezione Fisica Tecnica ed Energetica Facolta' d' Ingegneria

    2005-09-01

    In this report is presented a computational model for analysis of energy, materials and mass flux in a complex energy system, at regional scale level. Specifically is described a calculation model of electric power generation for emission forecasting of CO{sub 2}, SO{sub x}, NO{sub x}, particulate matter, ashes, limestone, chalks. [Italian] Dopo aver ricordato che nel campo della Fisica Tecnica ambientale acquista sempre piu' importanza l'analisi dei processi che interessano l'ambiente esterno in stretto rapporto con i processi di conversione ed uso dell'energia e con le condizioni di benessere nell'ambiente interno, in questa memoria viene presentato un modello computazionale per l'analisi dei flussi di energia, massa e materia che hanno luogo in un sistema energetico complesso esteso al territorio di una regione. In particolare viene descritto il modello di calcolo del sottosistema di generazione elettrica finalizzato alla previsione delle emissioni nocive riversate nell'ambiente naturale quali CO{sub 2}, SO{sub x}, NO{sub x}, polveri, ceneri, calcare, gessi.

  7. MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma.

    Science.gov (United States)

    Bonnin, Nathalie; Armandy, Emma; Carras, Julien; Ferrandon, Sylvain; Battiston-Montagne, Priscillia; Aubry, Marc; Guihard, Sébastien; Meyronet, David; Foy, Jean-Philippe; Saintigny, Pierre; Ledrappier, Sonia; Jung, Alain; Rimokh, Ruth; Rodriguez-Lafrasse, Claire; Poncet, Delphine

    2016-07-12

    At the time of diagnosis, 60% of patients with head and neck squamous cell carcinoma (HNSCC) present tumors in an advanced stage (III-IV) of disease and 80% will relapse within the first two years post-treatment, due to their frequent radio(chemo)resistance. To identify new molecular targets and companion biomarkers, we have investigated the miRNome of 75 stage III-IV oropharynx tumors without relapse (R) or with loco-regional relapse (non-responder, NR) within two years post-treatment. Interestingly, miR-422a was significantly downregulated in NR tumors, in agreement with the increase in cell proliferation and adhesion induced by miR-422a inhibition in vitro. Furthermore, we identified CD73/NT5E oncogene as target of miR-422a. Indeed, modulation of the endogenous level of miR-422a inversely influences the expression and the enzymatic activity of CD73. Moreover, knocking down CD73 mimics the effects of miR-422a upregulation. Importantly, in tumors, miR-422a and CD73 expression levels are inversely correlated, and both are predictive of relapse free survival - especially considering loco(regional) recurrence - in vitro two independent cohorts of advanced oropharynx or HNSCC (N=255) tumors. In all, we reported, for the first time, that MiR-422a and its target CD73 are involved in early loco(regional) recurrence of HNSCC tumors and are new targets for personalized medicine.

  8. Phylogenetic relationships in the Gesnerioideae (Gesneriaceae) based on nrDNA ITS and cpDNA trnL-F and trnE-T spacer region sequences.

    Science.gov (United States)

    Zimmer, Elizabeth A; Roalson, Eric H; Skog, Laurence E; Boggan, John K; Idnurm, Alexander

    2002-02-01

    The Gesnerioideae includes most of the New World members of the Gesneriaceae family and is currently considered to include five tribes: Beslerieae, Episcieae, Gesnerieae, Gloxinieae, and Napeantheae. This study presents maximum parsimony and maximum likelihood phylogenetic analyses of nuclear ribosomal DNA internal transcribed spacer regions (ITS), and the chloroplast DNA trnL intron, trnL-trnF intergenic spacer region, and trnE-trnT intergenic spacer region sequences. The ITS and cpDNA data sets strongly support the monophyly of a Beslerieae/Napeantheae clade; an Episcieae clade; a Gesnerieae clade; a Gloxinieae clade minus Sinningia, Sinningia relatives, and Gloxinia sarmentiana; and a Sinningia/Paliavana/Vanhouttea clade. This is the first study to provide strong statistical support for these tribes/clades. These analyses suggest that Sinningia and relatives should be considered as a separate tribe. Additionally, generic relationships are explored, including the apparent polyphyly of Gloxinia. Chromosome number changes are minimized on the proposed phylogeny, with the exception of the n = 11 taxa of the Gloxinieae. Scaly rhizomes appear to have been derived once in the Gloxinieae sensu stricto. The number of derivations of the inferior ovary is unclear: either there was one derivation with a reversal to a superior ovary in the Episcieae, or there were multiple independent derivations of the inferior ovary.

  9. The first coordinated observations of mid-latitude E-region quasi-periodic radar echoes and lower thermospheric 557.7-nm airglow

    Directory of Open Access Journals (Sweden)

    M. Yamamoto

    2005-10-01

    Full Text Available We present the first coordinated observations of quasi-periodic (QP radar echoes from sporadic-E (Es field-aligned irregularities (FAIs, OI 557.7-nm airglow, and neutral winds in a common volume over Shigaraki, Japan (34.9° N, 136.1° E on the night of 5 August 2002 during the SEEK-2 campaign. QP echo altitudes of 90-110 km were lower than usual by 10 km, enabling us to make a detailed comparison among QP echoes, airglow intensity, and neutral wind at around 96 km altitude. Eastward movement of the QP echo regions is consistent with the motions of neutral winds, airglow structures, and FAIs, suggesting that the electrodynamics of Es-layers is fundamentally controlled by the neutral atmospheric dynamics. During the QP echo event, the echo altitudes clearly went up (down in harmony with an airglow enhancement (subsidence that also moved to the east. This fact suggests that the eastward-moving enhanced airglow region included an upward (downward component of neutral winds to raise (lower the altitude of the wind-shear node responsible for the Es formation. The airglow intensity, echo intensity, and Doppler velocity of FAIs at around 96 km altitude fluctuated with periods from 10 min to 1h, indicating that these parameters were modulated with short-period atmospheric disturbances. Some QP echo regions below 100km altitude contained small-scale QP structures in which very strong neutral winds exceeding 100 m/s existed. The results are compared with recent observations, theories, and simulations of QP echoes. Keywords. Ionosphere (Ionosphere-atmosphere interactions; Ionospheric irregularities; Mid-latitude ionosphere

  10. A Study on Barriers of E-learning from Viewpoint of University Staff and Students; Iranian Case Study, Islamic Azad University’s Branches, Region I (Fars

    Directory of Open Access Journals (Sweden)

    Sara Zolghadri

    2013-07-01

    Full Text Available This study aims to examine the key barriers of e-learning in the branches of Islamic Azad University, Region I (Fars Province from the viewpoint of university staff and students. In this descriptive survey, the barriers of e-learning were investigated with questionnaires and a sample comprising 1000 university staff and students. The results indicate that the lack of management support, impossibility of holding experimental meetings through e-learning, impossibility of university culture transfer and special problems of communicational infrastructures, the lack of easy access to computer systems and communicational lines and the lack of appropriate strategies of providing security are among the most important executional and infrastructural barriers of developing e-learning. In addition, the lack of expert staff in the fields of modern educational technologies, the lack of understanding of planners and the resistance of the beneficial against the implementation of electronic learning are the most important human barriers. Finally, the insufficiency of investment and required facilities, high cost of educational technologies’ equipment and costs relating to updating are among the most noticeable financial barriers in front of learning development. Accordingly, in order to break through such problems, we can utilize some strategies, tactics and measures like enhancing the level of awareness, motivation of the staff and students, institutionalizing the university culture during the process of electronic learning, considering a sufficient budget for investing in the implementation and development of e-learning, updating facilities and developing the communicational infrastructures. The results of this study can be utilized by managers and executers of electronic learning. In the generalization of the findings, however, caution must be exercised and any aspect should be considered just like any other study.

  11. A Influência da Imersão Institucional e Regional na Cooperação entre Pesquisadores no Brasil.

    Directory of Open Access Journals (Sweden)

    Rossoni, Luciano

    2009-06-01

    Full Text Available A análise do campo científico como uma rede social vem ampliando o entendimento das relações entre pesquisadores como atividade social. Além do significado dado pelos relacionamentos entre pares, questões estruturais emergem, fomentando explicações sobre como níveis sociais mais amplos condicionam as relações de co-autoria. Buscando contribuir para essa linha de estudos, o objetivo do presente artigo é analisar como as relações entre pesquisadores da área de administração da informação no Brasil são condicionadas pela imersão institucional e regional. Para tanto, foi utilizado o método da análise de redes sociais, mais especificamente a técnica de generalized blockmodels para testar modelos relacionais de homofilia e centro-periferia. Verificou-se que todos os modelos relacionados ao padrão de homofilia foram significativos e que o condicionamento devido à instituição foi mais homogêneo do que o decorrente das unidades federativas. Diferentemente do esperado, os padrões do tipo centro-periferia mostraram-se pouco significativos. Mas, pautando-se no resultado que foi significativo, verifica-se que existe algum mecanismo de seleção privilegiado por pesquisadores que fazem parte de algumas regiões, seja pelo acesso a recursos e informações, seja pela existência de programas mais tradicionais. Adicionalmente, o estudo aponta para implicações teóricas e práticas, destacando possibilidades de estudos futuros.

  12. Analysis of Ig V{sub H} region genes encoding IgE antibodies in splenic B lymphocytes of a patient with asthma

    Energy Technology Data Exchange (ETDEWEB)

    Snow, R.E.; Chapman, C.J.; Stevenson, F.K. [Southampton Univ. Hospitals (United Kingdom)] [and others

    1995-05-15

    An atopic patient with hypersensitivity against house dust mite died as a result of an asthmatic attack. A portion of the spleen was obtained and was used to analyze the spectrum of Ig heavy chain V regions involved in encoding IgE Abs. A nested PCR technique generated 14 cloned V{sub H} sequences that had distinct CDR3 regions; 5 of 14 were derived from the minor V{sub H}5 family, and the remainder derived from the larger families, V{sub H}3 (6 of 14) and V{sub H}4 (3 of 14). One of the V{sub H}3-derived sequences was present as a repeated sequence in three clones. A control PCR with the same V{sub H} primers in combination with J{sub H} primers yielded only 1 of 13 sequences from V{sub H}5, indicating preferential V{sub H}5 usage only for IgE. Analysis of V{sub H}5-C{epsilon} sequences revealed usage of a single gene, DP73, with extensive mutations and several {open_quotes}hot spots{close_quotes} containing common replacement amino acids. However, there was no concentration of replacement mutations in the CDRs, which conventionally would indicate a role for Ag selection. The V{sub H}3 and V{sub H}4 genes in combination with C{epsilon} also harbored extensive somatic mutations. From these findings in splenic B lymphocytes, and those of a previous study of blood lymphocytes, it seems that preferential usage of V{sub H}5 genes and extensive somatic hypermutation are characteristic of B cells synthesizing IgE in patients with allergic disease. 27 refs., 3 figs., 2 tabs.

  13. Measurement of Target and Double-spin Asymmetries for the $\\vec e\\vec p\\to e\\pi^+ (n)$ Reaction in the Nucleon Resonance Region at Low $Q^2$

    CERN Document Server

    Zheng, X; Bosted, P; Deur, A; Drozdov, V; Fassi, L El; Kang, Hyekoo; Kovacs, K; Kuhn, S; Long, E; Phillips, S K; Ripani, M; Slifer, K; Smith, L C; Adikaram, D; Akbar, Z; Amaryan, M J; Pereira, S Anefalos; Asryan, G; Avakian, H; Badui, R A; Ball, J; Baltzell, N A; Battaglieri, M; Batourine, V; Bedlinskiy, I; Biselli, A S; Briscoe, W J; Bültmann, S; Burkert, V D; Carman, D S; Celentano, A; Chandavar, S; Charles, G; Chen, J -P; Chetry, T; Choi, Seonho; Ciullo, G; Clark, L; Colaneri, L; Cole, P L; Compton, N; Contalbrigo, M; Crede, V; D'Angelo, A; Dashyan, N; De Vita, R; De Sanctis, E; Djalali, C; Dodge, G E; Dupre, R; Egiyan, H; Alaoui, A El; Elouadrhiri, L; Eugenio, P; Fanchini, E; Fedotov, G; Fersch, R; Filippi, A; Fleming, J A; Gevorgyan, N; Ghandilyan, Y; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Gleason, C; Golovach, E; Gothe, R W; Griffioen, K A; Guidal, M; Guler, N; Guo, L; Hanretty, C; Harrison, N; Hattawy, M; Hicks, K; Holtrop, M; Hughes, S M; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Jenkins, D; Jiang, H; Jo, H S; Joosten, S; Keller, D; Khachatryan, G; Khandaker, M; Kim, A; Kim, W; Klein, F J; Kubarovsky, V; Lanza, L; Lenisa, P; Livingston, K; MacGregor, I J D; Markov, N; McKinnon, B; Mirazita, M; Mokeev, V; Movsisyan, A; Munevar, E; Camacho, C Munoz; Murdoch, G; Nadel-Turonski, P; Net, L A; Ni, A; Niccolai, S; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Paolone, M; Paremuzyan, R; Park, K; Pasyuk, E; Peng, P; Pisano, S; Pogorelko, O; Price, J W; Puckett, A J R; Raue, B A; Rizzo, A; Rosner, G; Rossi, P; Roy, P; Sabatié, F; Salgado, C; Schumacher, R A; Sharabian, Y G; Skorodumina, Iu; Smith, G D; Sokhan, D; Sparveris, N; Stankovic, I; Strakovsky, I I; Strauch, S; Taiuti, M; Tian, Ye; Ungaro, M; Voskanyan, H; Voutier, E; Walford, N K; Watts, D P; Wei, X; Weinstein, L B; Wood, M H; Zachariou, N; Zhang, J

    2016-01-01

    We report measurements of target- and double-spin asymmetries for the exclusive channel $\\vec e\\vec p\\to e\\pi^+ (n)$ in the nucleon resonance region at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). These asymmetries were extracted from data obtained using a longitudinally polarized NH$_3$ target and a longitudinally polarized electron beam with energies 1.1, 1.3, 2.0, 2.3 and 3.0 GeV. The new results are consistent with previous CLAS publications but are extended to a low $Q^2$ range from $0.0065$ to $0.35$ (GeV$/c$)$^2$. The $Q^2$ access was made possible by a custom-built Cherenkov detector that allowed the detection of electrons for scattering angles as low as $6^\\circ$. These results are compared with the unitary isobar models JANR and MAID, the partial-wave analysis prediction from SAID and the dynamic model DMT. In many kinematic regions our results, in particular results on the target asymmetry, help to constrain the polarization-dependent components of these models.

  14. Measurement of target and double-spin asymmetries for the e ⃗p ⃗→e π+(n ) reaction in the nucleon resonance region at low Q2

    Science.gov (United States)

    Zheng, X.; Adhikari, K. P.; Bosted, P.; Deur, A.; Drozdov, V.; El Fassi, L.; Kang, Hyekoo; Kovacs, K.; Kuhn, S.; Long, E.; Phillips, S. K.; Ripani, M.; Slifer, K.; Smith, L. C.; Adikaram, D.; Akbar, Z.; Amaryan, M. J.; Anefalos Pereira, S.; Asryan, G.; Avakian, H.; Badui, R. A.; Ball, J.; Baltzell, N. A.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; Briscoe, W. J.; Bültmann, S.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Chen, J.-P.; Chetry, T.; Choi, Seonho; Ciullo, G.; Clark, L.; Colaneri, L.; Cole, P. L.; Compton, N.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; De Sanctis, E.; Djalali, C.; Dodge, G. E.; Dupre, R.; Egiyan, H.; El Alaoui, A.; Elouadrhiri, L.; Eugenio, P.; Fanchini, E.; Fedotov, G.; Fersch, R.; Filippi, A.; Fleming, J. A.; Gevorgyan, N.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Gleason, C.; Golovach, E.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hanretty, C.; Harrison, N.; Hattawy, M.; Hicks, K.; Holtrop, M.; Hughes, S. M.; Ilieva, Y.; Ireland, D. G.; Ishkhanov, B. S.; Isupov, E. L.; Jenkins, D.; Jiang, H.; Jo, H. S.; Joosten, S.; Keller, D.; Khachatryan, G.; Khandaker, M.; Kim, A.; Kim, W.; Klein, F. J.; Kubarovsky, V.; Lanza, L.; Lenisa, P.; Livingston, K.; MacGregor, I. J. D.; Markov, N.; McKinnon, B.; Mirazita, M.; Mokeev, V.; Movsisyan, A.; Munevar, E.; Munoz Camacho, C.; Murdoch, G.; Nadel-Turonski, P.; Net, L. A.; Ni, A.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Paolone, M.; Paremuzyan, R.; Park, K.; Pasyuk, E.; Peng, P.; Pisano, S.; Pogorelko, O.; Price, J. W.; Puckett, A. J. R.; Raue, B. A.; Rizzo, A.; Rosner, G.; Rossi, P.; Roy, P.; Sabatié, F.; Salgado, C.; Schumacher, R. A.; Sharabian, Y. G.; Skorodumina, Iu.; Smith, G. D.; Sokhan, D.; Sparveris, N.; Stankovic, I.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Tian, Ye; Ungaro, M.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zhang, J.; Zonta, I.; CLAS Collaboration

    2016-10-01

    We report measurements of target- and double-spin asymmetries for the exclusive channel e ⃗p ⃗→e π+(n ) in the nucleon resonance region at Jefferson Lab using the CEBAF Large Acceptance Spectrometer (CLAS). These asymmetries were extracted from data obtained using a longitudinally polarized NH3 target and a longitudinally polarized electron beam with energies 1.1, 1.3, 2.0, 2.3, and 3.0 GeV. The new results are consistent with previous CLAS publications but are extended to a low Q2 range from 0.0065 to 0.35 (GeV/c ) 2 . The Q2 access was made possible by a custom-built Cherenkov detector that allowed the detection of electrons for scattering angles as low as 6∘. These results are compared with the unitary isobar models JANR and MAID, the partial-wave analysis prediction from SAID, and the dynamic model DMT. In many kinematic regions our results, in particular results on the target asymmetry, help to constrain the polarization-dependent components of these models.

  15. Anestesia regional intravenosa primeiro centenário (1908-2008: Início, desenvolvimento e estado atual A anestesia regional intravenosa primer centenario (1908-2008: Inicio, desarrollo y estado actual Intravenous regional anesthesia first century (1908-2008: Beggining, development, and current status

    Directory of Open Access Journals (Sweden)

    Almiro dos Reis Jr

    2008-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A anestesia regional intravenosa completa neste ano de 2008 um século de existência. Sendo técnica anestésica amplamente utilizada, justifica-se recordar o fato, comemorar a data, lembrar aos anestesiologistas brasileiros o processo evolutivo pelo qual ela passou, sobretudo nos últimos 40 anos, e prestar um tributo àquele que a iniciou: August Karl Gustav Bier. CONTEÚDO: O texto relata a origem da anestesia locorregional em geral e da anestesia regional intravenosa em particular, desde a introdução do garroteamento de membros e da descoberta e do aperfeiçoamento das agulhas de punção, das seringas e dos anestésicos locais. São descritos os detalhes técnicos inicialmente utilizados por Bier e os conceitos fisiopatológicos e clínicos por ele emitidos em princípios do século XX. Retrata a evolução inicial e das décadas seguintes da anestesia regional intravenosa, cita os pioneiros nacionais e internacionais no seu uso, explica as razões do seu estudo científico relativamente tardio, descreve as principais contribuições havidas até hoje para sua utilização eficiente e segura. Finalmente, narra o estado atual dos principais conhecimentos adquiridos ao longo do tempo, como mecanismo e local de ação do anestésico e da isquemia, uso de soluções anestésicas modernas, aperfeiçoamento da analgesia pós-operatória e do bloqueio motor, conceitos farmacocinéticos e fisiopatológicos e melhor interpretação das principais complicações possíveis. CONCLUSÕES: A anestesia regional intravenosa é técnica anestésica criada por A.K.G. Bier há exatamente 100 anos. Evoluiu pouco e lentamente na primeira metade do século XX e muito nos últimos anos, graças a numerosos desenvolvimentos técnicos, fisiopatológicos, farmacológicos, farmacocinéticos e clínicos, para o que a Anestesiologia brasileira deu grande contribuição. Completando neste ano de 2008 seu primeiro centenário, a anestesia

  16. 全球多区域CGE模型的构建及其3E扩展%Global multi-regional CGE model with its 3E extensions

    Institute of Scientific and Technical Information of China (English)

    牛玉静; 陈文颖; 吴宗鑫

    2014-01-01

    全球多区域可计算一般均衡模型(computable general equilibrium,CGE)是最重要的全球气候政策评估工具之一.该文给出了自主开发的全球多区域可计算一般均衡模型(global applied general equilibrium model,GAGE)的理论框架,描述了区域内框架的地区账户收入分配方案和生产模块的嵌套结构以及区域间框架的国际贸易结构和2个虚拟国际机构的构建,即建立国际运输部门和国际银行用于描述国际贸易的运输服务供需以及投资的区域间流动.在标准GAGE模型的基础上进行了能源-环境-经济扩展,以描述能源与资本之间以及各类能源之间的替代关系.碳减排情景研究结果验证了GAGE模型理论框架的合理性,展示了能源替代对于减排潜力的显著影响.%Global multi-regional computable general equilibrium (CGE) models are some of the most important tools for global climate policy assessments.This paper presents the theoretical framework for a global multi-regional CGE model called the global applied general equilibrium model (GAGE) developed using the general algebraic modeling system.The intra-regional framework analyzes the income distribution in regional households and the nested production module structure,while the inter-regional framework focuses on the international trade structure and the construction of two fictitious global institutes,an international transportation sector and a global bank,which were established to describe the supply and demand of transportation services in international trade and investment flows between regions.The GAGE model was used with energy-environment-economy (3E)extensions to describe the substitution between capital and energy and between different fuels.The results of carbon reduction scenarios verify the reasonableness of the theoretical framework and show that energy substitution significantly impacts emissions reduction potential.

  17. Teaching Astronomy through e-learning in Poland: Astronomical Education in teacher training conducted by the Regional Teacher Training Center in Skierniewice

    Science.gov (United States)

    Dabrowska, A. E.

    2014-12-01

    Regional Teacher Training Centre (RTTC) in Skierniewice is one of 49 public, accredited institutions in Poland carrying out it statutory goals at the regional level. It has been operating since 1989 and is responsible for organizing of support of schools, institutions, networks of teachers for cooperation and self-education, organizing various forms of in-service training and disseminating examples of good practice. It also has rich experience in teaching by using modern Interactive Computer Technology (ICT) tools and e-learning platform. I present examples about teaching of Astronomical issues through teacher training both as hands on workshops as well as through e-learning. E-learning is playing an important role in organizing educational activities not only in the field of modern didactic but also in learning Science subjects. Teachers find e-learning as a very economical, easy and convenient way of learning and developing their knowledge and skills. Moreover, they are no longer afraid of using new ICT tools and programs which help them to cooperate with students effectively. Since 2011 RTTC in Skierniewice has been an organizer of many on-line in-service programs for teachers, in learning Science. Some of them are organized as blended-learning programs which allow teachers to participate first in hands on activities then continue learning on the Moodle platform. These courses include two 15 and 30-hours of Astronomical topics. Teachers have the opportunity to gain knowledge and receive materials not only about the Universe and the Solar System but also can learn to use tools like Stellarium, Celestia, WorldWide Telescope, Your Sky and other tools. E-learning modules consist of both publishing learning materials in various forms, eg. PowerPoint Presentations, Word & PDF materials, web sites, publications, working sheets as well as practical duties like participation in chats, forums, tasks, Wiki, group workshop. Teachers use these materials for extending their

  18. L' influenza nella regione Lazio dal 1999 al 2003: casi di sindrome influenzale, ricoveri ospedalieri per malattie respiratorie e coperture vaccinali

    Directory of Open Access Journals (Sweden)

    A. Pasquarella

    2003-05-01

    Full Text Available

    Obiettivi: 1 Descrivere l’andamento dei ricoveri ospedalieri per patologie respiratorie acute e croniche concomitanti alle epidemie stagionali da virus influenzale dal 1999 al 2003, in relazione con la segnalazione dei casi di sindrome influenzale (ILI da parte dei medici sentinella. 2 Misurare l’eccesso dell’ospedalizzazione influenza-correlata nelle diverse fasce di età rispetto ai periodi non epidemici. 3 Analizzare le modificazioni del ricorso al ricovero ospedaliero in relazione al tasso di copertura della vaccinazione antinfluenzale nella popolazione anziana, su scala regionale e nelle diverse ASL.

    Metodi: sono stati estratti dal Sistema Informativo
    Ospedaliero i ricoveri per patologie respiratorie
    influenza-correlate (codici ICD9-CM: 480-487; 460-
    466; 490-496 relativi agli anni 1999-2003.
    L’incidenza di ILI è stata stimata sulla base delle
    segnalazioni dei medici sentinella afferenti alla
    rete FLU-ISS dell’Istituto Superiore di Sanità.

    Per il calcolo dei tassi di copertura è stato utilizzato l’archivio
    nominativo dei soggetti vaccinati contro l’influenza,
    attivo nella regione Lazio dal 1999. Nel periodo considerato sono stati messi in relazione i tassi di ospedalizzazione età-specifici, le incidenze di ILI e le coperture vaccinali. L’eccesso di ospedalizzazione è stato misurato confrontando i tassi relativi ai periodi epidemici e non epidemici.

    Risultati: i tassi di ospedalizzazione per malattie respiratorie sono risultati costantemente superiori nei periodi di maggiore circolazione virale, in particolare negli ultrasessantaquattrenni. Con il progressivo aumento del tasso di copertura vaccinale regionale (da circa il 25% della stagione 1999-2000 a oltre il 60% della stagione 2002-2003 non si è registrata una corrispondente diminuzione dei ricoveri ospedalieri per patologie influenza-correlate.
    L

  19. Modulation of thyroid hormone receptor transactivation by the early region 1A (E1A-like inhibitor of differentiation 1 (EID1

    Directory of Open Access Journals (Sweden)

    Diana Vargas

    2008-01-01

    Full Text Available Transcriptional activation (TA mediated by the effect of thyroid hormones on target genes requires co-activator proteins such as the early region 1A (E1A associated 300 kDa binding protein (p300 and the cAMP response element binding protein (CREB binding protein (CBP, known as the p300/CBP complex, which acetylate histones 3 and 4 to allow transcriptional machinery access to the target gene promoter. Little is known on the role of p300 in thyroid hormone receptor (TR mediated TA but the E1A-like inhibitor of differentiation 1 (EID1, an inhibitor of p300 histone acetyltransferase (HAT, is a functional homolog of E1A and may inhibit myogenic differentiation factor D (MyoD transcriptional activity and reduces muscle cell differentiation. We evaluated the influence of EID1 on TR-mediated transcriptional activity using transfection and mammalian two-hybrid studies to show that EID1 may partially reduces TA activity of the TR receptor, probably due to p300 blockage since EID1 mutants cannot reduce TR-mediated TA. The EID1 does not affect the function of p160 co-activator proteins (160 kDa proteins of steroid receptor co-activators and is functionally independent of co-repressor proteins or TR binding. Summarizing, EID1 reduces TR-mediated transcriptional activity by blocking p300 and may play an important role in thyroid receptor activity in muscle and other tissues.

  20. Human papilloma virus early proteins E6 (HPV16/18-E6) and the cell cycle marker P16 (INK4a) are useful prognostic markers in uterine cervical carcinomas in Qassim Region--Saudi Arabia.

    Science.gov (United States)

    Omran, O M; AlSheeha, M

    2015-01-01

    Cervical cancer is a common and an important public health problem for adult women in developing countries. In contrast, cervical cancer incidence is low in Saudi Arabia. High-risk types of human papilloma viruses (HPV16 and HPV18) are the most significant risk factors for cervical cancer. HPV16/18-E6 oncoprotein is associated with HPV etiology, viral persistence and epithelial transformation. Cell cycle protein p16 INK4a (p16) plays an important role in the pathophysiology of cervical carcinomas. The aims of this study were to investigate the expression of HPV16/18-E6 and p16 in uterine cervical carcinomas in Qassim Region--Saudi Arabia, and to relate the results to the established clinicopathological prognostic parameters (age of the patient, educational level, birth control methods, number of pregnancy, smoking status, degree of histological differentiation, clinical stage, and lymph node metastasis) The study included 40 specimens of uterine cervical squamous cell carcinomas diagnosed and confirmed by biopsy. Histopathological classification of cervical tumors cases was performed according to the International Federation of Gynecology and Obstetrics (FIGO). Immunohistochemical analysis for HPV16/18-E6 and p16 were carried out on formalin-fixed paraffin-embedded sections of cervical tissues using avidin-biotin peroxidase method. There was a significant statistical correlation between HPV16/18-E6 expression in cervical carcinoma and nationality, smoking status and size of the tumor. HPV16/18-E6 oncoprotein expression in normal lymphocytes and endothelial cells in the tumor tissues and the adjacent normal cervical tissues suggest the possibility that HPV infection might spread to other organs through blood circulation. P16 expression has been correlated with high grade, stage of cervical SCC and HPV16/18-E6 expression. The current study supports the critical function of p16 and HPV16/18-E6 as specific markers for cervical carcinoma. However the potential for usage

  1. Fatores associados com o comportamento sexual e reprodutivo entre adolescentes das regiões Sudeste e Nordeste do Brasil Factors associated with sexual and reproductive behavior among adolescents from the Northeast and Southeast regions of Brazil

    Directory of Open Access Journals (Sweden)

    Iúri da Costa Leite

    2004-04-01

    Full Text Available Neste artigo são analisados os fatores associados com o comportamento sexual e reprodutivo das adolescentes das regiões Nordeste e Sudeste do Brasil. A análise é implementada focando três dimensões deste processo: a iniciação sexual, o uso de métodos anticoncepcionais na primeira relação sexual e fecundidade. Modelos hierárquicos são implementados, pois adolescentes selecionadas de uma mesma comunidade devem ter comportamento sexual e reprodutivo mais semelhantes do que adolescentes selecionadas de áreas diferentes. O nível educacional da adolescente revelou-se o fator de risco mais importante nas três análises implementadas. Adolescentes com cinco ou mais anos de escolaridade são menos prováveis de ter a primeira relação sexual na adolescência; mais propensas a usar métodos anticoncepcionais nesta relação e apresentam menores riscos de ter filhos, quando comparadas com adolescentes com menos de cinco anos de escolaridade.This article calls attention to factors associated with sexual and reproductive behavior among adolescents from the Northeast and Southeast regions of Brazil. The analyses focus on three dimensions of this process: sexual initiation, use of contraceptives in the first sexual relationship, and fertility. Hierarchical models are implemented, because adolescents selected from the same community are more likely to have similar sexual and reproductive behavior than those from different communities. Level of schooling was the most important risk factor in the three analyses. Girls with 5 or more years of schooling were less likely to have their first sexual relationship during adolescence and more likely to use contraceptive methods in this relationship, besides demonstrating less risk of having children than their counterparts with less than 5 years of schooling.

  2. Son huasteco e identidad regional

    Directory of Open Access Journals (Sweden)

    Rosa María Bonilla Burgos

    2013-04-01

    Full Text Available La población de la región Huasteca es partícipe de manifestaciones musicales en diferentes ámbitos, lo cual permite reconocer que entre todos los géneros utilizados destaca el son huasteco y su correspondiente bailable llamado huapango. Dichas expresiones musicales se impregnan de los ambientes tanto físico como social que viven constantemente. Es a través de las letras de los sones huastecos que se desarrolla el mecanismo para reflejar el mundo natural que perciben, y los acontecimientos que les suceden, cobrando una importancia que deriva en una identificación que trasciende. Conciben su entorno y lo refieren con sentido de pertenencia-apropiación, que les permite recrear su vida y fundirse en una identificación cultural a la que se le llamará “identidad regional”. La relevancia de considerar una expresión musical de estas características radica en que se preserva y enriquece constantemente unificando un área de México que no necesariamente corresponde a límites políticos establecidos en las diferentes etapas históricas.

  3. Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level

    Directory of Open Access Journals (Sweden)

    Ying Zhao

    2012-01-01

    Full Text Available Background: Mechanism leading to an abrupt hair loss in diffuse alopecia areata (AA remains unclear. Aims: To explore the characteristics of diffuse AA and possible factors involved in its pathogenesis. Methods: Clinical and laboratory data of 17 diffuse AA patients and 37 patchy AA patients were analyzed retrospectively. Serum IgE level was evaluated in all diffuse and patchy AA patients, as well as 27 healthy subjects without hair loss to serve as normal control. Univariate analysis was performed using Fisher′s exact test and Wilcoxon rank-sum test. Associations between inflammatory cell infiltration and laboratory values were analyzed using Spearman rank correlation test. Results: The mean age of patients with diffuse AA was 27 years with a mean disease duration of 1.77 months. All of them presented in spring or summer with an acute onset of diffuse hair loss preceded by higher incidence of scalp pruritus. Although no statistically significant difference on the incidence of atopic disease among three groups has been found, serum IgE level in diffuse AA was higher than that in healthy controls, but was comparable to that in patchy AA group. Histopathology of lesional scalp biopsies showed more intense infiltration comprising of mononuclear cells, eosinophils, CD3 + , and CD8 + T cells around hair bulbs in diffuse AA group than in patchy AA group. Moreover, IgE level in diffuse AA patients positively correlated with intensity of infiltration by mononuclear cells, eosinophils, and CD8 + T cells. Conclusions: Hypersensitivity may be involved in pathogenesis of diffuse AA. The acute onset of diffuse AA may be related to intense local inflammatory infiltration of hair loss region and an increase in serum IgE level.

  4. Adaptive policy responses to water shortage mitigation in the arid regions--a systematic approach based on eDPSIR, DEMATEL, and MCDA.

    Science.gov (United States)

    Azarnivand, Ali; Chitsaz, Nastaran

    2015-02-01

    Most of the arid and semi-arid regions are located in the developing countries, while the availability of water in adequate quantity and quality is an essential condition to approach sustainable development. In this research, "enhanced Driving force-Pressure-State-Impact-Response (eDPSIR)" sustainability framework was applied to deal with water shortage in Yazd, an arid province of Iran. Then, the Decision Making Trial and Evaluation Laboratory (DEMATEL) technique was integrated into the driven components of eDPSIR, to quantify the inter-linkages among fundamental anthropogenic indicators (i.e. causes and effects). The paper's structure included: (1) identifying the indicators of DPSIR along with structuring eDPSIR causal networks, (2) using the DEMATEL technique to evaluate the inter-relationships among the causes and effects along with determining the key indicators, (3) decomposing the problem into a system of hierarchies, (4) employing the analytic hierarchy process (AHP) technique to evaluate the weight of each criterion, and (5) applying complex proportional assessment with Grey interval numbers (COPRAS-G) method to obtain the most conclusive adaptive policy response. The systematic quantitative analysis of causes and effects revealed that the root sources of water shortage in the study area were the weak enforcement of law and regulations, decline of available freshwater resources for development, and desertification consequences. According to the results, mitigating the water shortage in Yazd could be feasible by implementation of such key adaptive policy-responses as providing effective law enforcement, updating the standards and regulations, providing social learning, and boosting stakeholders' collaboration.

  5. A fresh look at the mechanisms behind auroral E region irregularities, based on interferometry results from the March 17 storm of 2015.

    Science.gov (United States)

    St-Maurice, Jean-Pierre; Chau, Jorge

    2016-07-01

    During the strong magnetic storm of March 17, 2015, auroral echoes were detected by mid latitude radars operating at 32.5MHz and 36.2 MHz in Northern Germany. As shown in a separate presentation, thanks to several interferometry links, the retrieved spectra could be localized and superposed spectra could be separated in the presence of multiple spectral signatures from different locations with similar ranges. The radars detected four types of spectra. The first type consisted of spectra with moderate widths with a mean Doppler shift comparable to the expected ion-acoustic speed. Those are the often observed so-called Type I waves. They are Farley-Buneman waves at their peak amplitude. The second type had broad spectra with mean Doppler shifts typically less than 200 m/s. Such so-called Type II waves are routinely observed in auroral and equatorial E regions. Those waves are from Farley-Buneman waves observed from a direction perpendicular to their leading wave fronts and are therefore seen at large flow angles. The third class of echoes observed during the storm consisted of very narrow spectra with a Doppler shift that varied little from 180 m/s. These have been described as Type III waves in the literature and were never fully understood, in large part owing to a lack of localization technique. For our observations, interferometry revealed that they came from altitudes well below 100 km, with a target motion of 800 m/s or more in spite of the small Doppler shift. This contrasted with the fourth type, which came from the upper part of the unstable E region and was made once again of very narrow spectra moving at close to the line-of-sight velocity (as found through target motion) when the plasma drift was particularly large, of the order of 1400 m/s. This presentation will show that the Type III waves were in great agreement with the notion of maximum amplitude unstable Farley-Buneman waves excited by very large electric fields in a region strongly affected by non

  6. A epidemia de AIDS no Brasil e as desigualdades regionais e de oferta de serviço The AIDS epidemic in Brazil and differences according to geographic region and health services supply

    Directory of Open Access Journals (Sweden)

    Alexandre Grangeiro

    2010-12-01

    Full Text Available Identificar diferentes perfis da epidemia de AIDS no Brasil relacionando-os à organização do setor saúde, às situações relacionadas ao risco de infecção e ao grau de implantação da resposta. Municípios brasileiros foram agrupados segundo magnitude e tendência da epidemia entre 2002 e 2006, e estudados por meio de indicadores obtidos em bases de dados secundários. Municípios com epidemias de grande magnitude (39% apresentaram um maior número de situações associadas ao risco e os com tendência de aumento da incidência (11,5% menor grau de implantação da resposta. Cidades com grandes epidemias que reduzem/estabilizam concentraram 68,6% dos Centros de Testagens, 75,8% dos ambulatórios e 81,4% dos exames anti-HIV feitos no sistema de saúde. Ações preventivas em escolas e na atenção básica apresentaram baixa cobertura comparativamente à área assistencial. Diferenças entre regiões foram observadas. Desigualdades no grau de implantação da resposta ao HIV podem contribuir para a ocorrência de diferentes perfis da epidemia no país.The aim of this study was to identify different profiles in the AIDS epidemic in Brazil by relating them to the health sector's organization, situations involving increased risk of infection, and the degree of implementation of the response by health services. The Brazilian municipalities (counties were grouped according to the magnitude of the epidemic and its trends from 2002 and 2006, and were then studied using indicators obtained from secondary databases. Municipalities with large epidemics (39% displayed more situations associated with risk of infection, and those with an upward trend in incidence (11.5% showed a lower degree of response. Cities with large epidemics but with downward or stable trends had 68.6% of all the anonymous testing centers and 75.8% of the outpatient clinics, and performed 81.4% of all the HIV antibody tests in the health system. Preventive measures in schools

  7. The influence of land use on the concentration and vertical distribution of PBDEs in soils of an e-waste recycling region of South China.

    Science.gov (United States)

    Cheng, Zhineng; Wang, Yan; Wang, Shaorui; Luo, Chunling; Li, Jun; Chaemfa, Chakra; Jiang, Haoyu; Zhang, Gan

    2014-08-01

    The vertical distribution of polybrominated diphenyl ethers (PBDEs) in soil at four sites within an e-waste recycling region of South China was investigated. PBDE concentrations in soil ranged from 1.38 to 765 ng/g. There was a trend of decreasing PBDE concentration with soil depth, especially in the paddy field. However, high concentrations of BDE-209 were found in deeper soils indicating a highly preferential migration. There was a stronger correlation between PBDEs and total organic carbon (TOC), compared to dissolved organic carbon (DOC), which suggests that the association between non-dissolved organic carbon (NDOC) and PBDEs is stronger than for DOC. Different land use types, in particular differences in farming activities, significantly influenced the vertical distribution of PBDEs in soils. PBDEs displayed a higher leaching tendency in moist paddy soil than in drier soils. The frequent flooding condition in paddy field may facilitate the vertical transfer of PBDEs to the deeper soils.

  8. Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs.

    Science.gov (United States)

    Wang, Lizhen; Sun, Yani; Du, Taofeng; Wang, Chengbao; Xiao, Shuqi; Mu, Yang; Zhang, Gaiping; Liu, Lihong; Widén, Frederik; Hsu, Walter H; Zhao, Qin; Zhou, En-Min

    2014-12-01

    The antigenic domains located in the C-terminal 268 amino acid residues of avian hepatitis E virus (HEV) capsid protein have been characterized. This region shares common epitopes with swine and human HEVs. However, epitopes in the N-terminal 338 amino acid residues have never been reported. In this study, an antigenic domain located between amino acids 23 and 85 was identified by indirect ELISA using the truncated recombinant capsid proteins as coating antigens and anti-avian HEV chicken sera as primary antibodies. In addition, this domain did not react with anti-swine and human HEV sera. These results indicated that the N-terminal 338 amino acid residues of avian HEV capsid protein do not share common epitopes with swine and human HEVs. This finding is important for our understanding of the antigenicity of the avian HEV capsid protein. Furthermore, it has important implications in the selection of viral antigens for serological diagnosis.

  9. De coadjuvante a protagonista? Os desafios da diversidade cultural, da produção audiovisual independente e regional na TV Paga

    OpenAIRE

    Pessotto, Ana Heloiza Vita

    2016-01-01

    Esta pesquisa tem como objetivo a avaliação de eficiência da Lei do Serviço de Acesso Condicionado (Lei da TV paga - Lei 12.485/11) a partir dos indicadores: promoção da diversidade cultural, estímulo à produção independente e à produção regional. Para tal fim, a pesquisa apresenta um breve histórico da implantação do serviço de TV paga no Brasil com ênfase para a evolução das regulações direcionadas ao conteúdo. Descreve, com base no modelo do Ciclo de Políticas Públicas, o estágio de implem...

  10. O papel da integração regional para o Brasil: universalismo, soberania e percepção das elites

    OpenAIRE

    2008-01-01

    O objetivo deste trabalho é analisar o significado do Mercosul para a política exterior do Brasil. Para isso, discutiremos as percepções das elites brasileiras em relação ao processo de integração regional. A defesa do princípio da intergovernamentalidade está ligada à concepção do lugar do Mercosul nas relações internacionais do país. A grande valorização de princípios como o do universalismo e o de soberania acaba afetando o aprofundamento da integração. A hipótese deste trabalho é que a es...

  11. Measurement of the polarized structure function σLT' for p(e→,e'p)π0 in the Δ(1232) resonance region

    Science.gov (United States)

    Joo, K.; Smith, L. C.; Burkert, V. D.; Minehart, R.; Adams, G.; Ambrozewicz, P.; Anciant, E.; Anghinolfi, M.; Asavapibhop, B.; Audit, G.; Auger, T.; Avakian, H.; Bagdasaryan, H.; Ball, J. P.; Barrow, S.; Battaglieri, M.; Beard, K.; Bektasoglu, M.; Bellis, M.; Benmouna, N.; Bianchi, N.; Biselli, A. S.; Boiarinov, S.; Bouchigny, S.; Bradford, R.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Butuceanu, C.; Calarco, J. R.; Carman, D. S.; Carnahan, B.; Cetina, C.; Ciciani, L.; Cole, P. L.; Coleman, A.; Cords, D.; Corvisiero, P.; Crabb, D.; Crannell, H.; Cummings, J. P.; Desanctis, E.; Devita, R.; Degtyarenko, P. V.; Denizli, H.; Dennis, L.; Dharmawardane, K. V.; Dhuga, K. S.; Djalali, C.; Dodge, G. E.; Doughty, D.; Dragovitsch, P.; Dugger, M.; Dytman, S.; Dzyubak, O. P.; Eckhause, M.; Egiyan, H.; Egiyan, K. S.; Elouadrhiri, L.; Empl, A.; Eugenio, P.; Fatemi, R.; Feuerbach, R. J.; Ficenec, J.; Forest, T. A.; Funsten, H.; Gaff, S. J.; Gavalian, G.; Gilad, S.; Gilfoyle, G. P.; Giovanetti, K. L.; Girard, P.; Gordon, C. I.; Griffioen, K.; Guidal, M.; Guillo, M.; Guo, L.; Gyurjyan, V.; Hadjidakis, C.; Hakobyan, R. S.; Hardie, J.; Heddle, D.; Heimberg, P.; Hersman, F. W.; Hicks, K.; Hicks, R. S.; Holtrop, M.; Hu, J.; Hyde-Wright, C. E.; Ilieva, Y.; Ito, M. M.; Jenkins, D.; Kelley, J. H.; Khandaker, M.; Kim, K. Y.; Kim, K.; Kim, W.; Klein, A.; Klein, F. J.; Klimenko, A. V.; Klusman, M.; Kossov, M.; Kramer, L. H.; Kuang, Y.; Kuhn, S. E.; Kuhn, J.; Lachniet, J.; Laget, J. M.; Lawrence, D.; Li, Ji; Lima, A. C.; Lukashin, K.; Manak, J. J.; Marchand, C.; McAleer, S.; McNabb, J. W.; Mecking, B. A.; Mehrabyan, S.; Melone, J. J.; Mestayer, M. D.; Meyer, C. A.; Mikhailov, K.; Mirazita, M.; Miskimen, R.; Morand, L.; Morrow, S. A.; Mozer, M. U.; Muccifora, V.; Mueller, J.; Murphy, L. Y.; Mutchler, G. S.; Napolitano, J.; Nasseripour, R.; Nelson, S. O.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Niczyporuk, B. B.; Niyazov, R. A.; Nozar, M.; O'Rielly, G. V.; Opper, A. K.; Osipenko, M.; Park, K.; Pasyuk, E.; Peterson, G.; Philips, S. A.; Pivnyuk, N.; Pocanic, D.; Pogorelko, O.; Polli, E.; Pozdniakov, S.; Preedom, B. M.; Price, J. W.; Prok, Y.; Protopopescu, D.; Qin, L. M.; Raue, B. A.; Riccardi, G.; Ricco, G.; Ripani, M.; Ritchie, B. G.; Ronchetti, F.; Rossi, P.; Rowntree, D.; Rubin, P. D.; Sabatié, F.; Sabourov, K.; Salgado, C.; Santoro, J. P.; Sapunenko, V.; Sargsyan, M.; Schumacher, R. A.; Serov, V. S.; Sharabian, Y. G.; Shaw, J.; Simionatto, S.; Skabelin, A. V.; Smith, E. S.; Sober, D. I.; Spraker, M.; Stavinsky, A.; Stepanyan, S.; Stoler, P.; Strakovsky, I. I.; Strauch, S.; Taiuti, M.; Taylor, S.; Tedeschi, D. J.; Thoma, U.; Thompson, R.; Todor, L.; Tur, C.; Ungaro, M.; Vineyard, M. F.; Vlassov, A. V.; Wang, K.; Weinstein, L. B.; Weller, H.; Weygand, D. P.; Whisnant, C. S.; Wolin, E.; Wood, M. H.; Yegneswaran, A.; Yun, J.; Zhao, J.; Zhou, Z.

    2003-09-01

    The polarized longitudinal-transverse structure function σLT' has been measured in the Δ(1232) resonance region at Q2=0.40 and 0.65 GeV2. Data for the p(e→,e'p)π0 reaction were taken at Jefferson Lab with the CEBAF large acceptance spectrometer (CLAS) using longitudinally polarized electrons at an energy of 1.515 GeV. For the first time a complete angular distribution was measured, permitting the separation of different nonresonant amplitudes using a partial wave analysis. Comparison with previous beam asymmetry measurements at MAMI indicate a deviation from the predicted Q2 dependence of σLT' using recent phenomenological models.

  12. Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein

    DEFF Research Database (Denmark)

    Keck, Zhenyong; Wang, Wenyan; Wang, Yong

    2013-01-01

    polyclonal antibodies to aa 412 to 423 from HCV-infected individuals confirmed broad neutralization, conflicting findings have been reported on polyclonal antibodies to an adjacent region, aa 434 to 446, that may or may not interfere with neutralization by antibodies to aa 412 to 423. To define the interplay......A challenge for hepatitis C virus (HCV) vaccine development is defining conserved epitopes that induce protective antibodies against this highly diverse virus. An envelope glycoprotein (E2) segment located at amino acids (aa) 412 to 423 contains highly conserved neutralizing epitopes. While...... between these antibodies, we isolated human monoclonal antibodies (HMAbs) to aa 412 to 423, designated HC33-related HMAbs (HC33 HMAbs), and characterized their interactions with other HMAbs to aa 434 to 446. A subset of the HC33 HMAbs neutralized genotype 1 to 6 infectious cell culture-derived HCV virions...

  13. The antibody targeting the E314 peptide of human Kv1.3 pore region serves as a novel, potent and specific channel blocker.

    Directory of Open Access Journals (Sweden)

    Xiao-Fang Yang

    Full Text Available Selective blockade of Kv1.3 channels in effector memory T (T(EM cells was validated to ameliorate autoimmune or autoimmune-associated diseases. We generated the antibody directed against one peptide of human Kv1.3 (hKv1.3 extracellular loop as a novel and possible Kv1.3 blocker. One peptide of hKv1.3 extracellular loop E3 containing 14 amino acids (E314 was chosen as an antigenic determinant to generate the E314 antibody. The E314 antibody specifically recognized 63.8KD protein stably expressed in hKv1.3-HEK 293 cell lines, whereas it did not recognize or cross-react to human Kv1.1(hKv1.1, Kv1.2(hKv1.2, Kv1.4(hKv1.4, Kv1.5(hKv1.5, KCa3.1(hKCa3.1, HERG, hKCNQ1/hKCNE1, Nav1.5 and Cav1.2 proteins stably expressed in HEK 293 cell lines or in human atrial or ventricular myocytes by Western blotting analysis and immunostaining detection. By the technique of whole-cell patch clamp, the E314 antibody was shown to have a directly inhibitory effect on hKv1.3 currents expressed in HEK 293 or Jurkat T cells and the inhibition showed a concentration-dependence. However, it exerted no significant difference on hKv1.1, hKv1.2, hKv1.4, hKv1.5, hKCa3.1, HERG, hKCNQ1/hKCNE1, L-type Ca(2+ or voltage-gated Na(+ currents. The present study demonstrates that the antibody targeting the E314 peptide of hKv1.3 pore region could be a novel, potent and specific hKv1.3 blocker without affecting a variety of closely related K(v1 channels, KCa3.1 channels and functional cardiac ion channels underlying central nervous system (CNS disorders or drug-acquired arrhythmias, which is required as a safe clinic-promising channel blocker.

  14. Unusual 5 m E region field-aligned irregularities observed from Northern Germany during the magnetic storm of 17 March 2015

    Science.gov (United States)

    Chau, Jorge L.; St.-Maurice, Jean-Pierre

    2016-10-01

    Coherent E region echoes were observed during the 17 March 2015 storm at midlatitudes by multistatic wide field of view radars operating in northern Germany. Two of the stations operated in a monostatic configuration, while one link was set in bistatic mode. Interferometry made it feasible to locate the targets. While the radars were built to measure mesospheric winds from specular meteor echoes, the storm was so intense that it allowed them to observe auroral E region echoes for more than 4 h. All stations detected numerous examples of narrow spectra with slow (≈180 m/s) and fast (up to 1600 m/s) Doppler velocities. The target speeds were much faster than the Doppler velocities for the slow narrow echoes (more than 800 m/s versus 180 m/s) but comparable to the observed Doppler shift for the 1500 m/s narrow fast types. The narrow types came from localized horizontal structures 50 to 80 km wide in range. The fast narrow types came from the upper part of the altitudes associated with Farley-Buneman waves. The slow narrow structures were typically from altitudes lower than 100 km. Unexpectedly, the great majority of the echoes associated with more ordinary ion acoustic turbulence had a positive Doppler shift and came from the east. A companion paper uses these new observations to reevaluate the origin of the narrow echoes and of the asymmetry in the counts. Irrespective of the generation mechanisms, our observations indicate that a combination of unusually large electric field and strong precipitation is needed to produce the unusual echoes.

  15. O papel da integração regional para o Brasil: universalismo, soberania e percepção das elites The role of regional integration for Brazil: universalism, sovereignty, autonomy and elites' perception

    Directory of Open Access Journals (Sweden)

    Tullo Vigevani

    2008-01-01

    Full Text Available O objetivo deste trabalho é analisar o significado do Mercosul para a política exterior do Brasil. Para isso, discutiremos as percepções das elites brasileiras em relação ao processo de integração regional. A defesa do princípio da intergovernamentalidade está ligada à concepção do lugar do Mercosul nas relações internacionais do país. A grande valorização de princípios como o do universalismo e o de soberania acaba afetando o aprofundamento da integração. A hipótese deste trabalho é que a estrutura do Mercosul seria condizente com as percepções de parte das elites brasileiras. Argumentaremos que a estrutura atual é insuficiente para garantir a dinâmica da integração.The aim of this article is to analyse the role of Mercosur for the Brazilian foreign policy. We will discuss the perception of the Brazilian elites concerning the regional integration process. The defense of the principle of intergovernmentalism is related to the conception of Mercosur's place in the set of Brazilian international relations. The huge valuation of some principles, as universalism and sovereignty, ends up by affecting the deepening of integration. The hypothesis of this paper is that the Mercosur structure would be related with part of Brazilian elite's perceptions. Our argument is that the current structure is insufficient to guarantee the dynamics of the integration.

  16. Slow and fast narrow spectra aurora E region echoes during the March 17, 2015 storm at mid latitudes. Multi-static, multi-frequency radar observations

    Science.gov (United States)

    Chau, Jorge; St-Maurice, Jean-Pierre

    2016-07-01

    Coherent E region echoes were observed at midlatitudes during the March 17, 2015 storm. The observations came from multi-static, multi-frequency, wide-field of view radars operating at 32.55 and 36.2 MHz in northern Germany. Each of the three receiver stations used, two in monostatic and one in bistatic modes, allow interferometry. These radars systems are devoted primarily to the measurement of mesospheric winds from specular meteor echoes. However during this storm, the strongest of the current solar cycle, strong Radar Aurora echoes were observed during the day for more than four hours. Here we present the main features observed, with a specific emphasis on echoes presenting narrow spectra with slower (around 180 m/s) and faster (as fast as 1600 m/s) Doppler velocities, than nominal typical ion-acoustic velocity expected to be between 400 and 800 m/s. We find that in both types of echoes the range vs. time slopes are between 800 and 1400 m/s. They agree rather well with the Doppler velocity for the narrow fast types but do not agree at all in the narrow slow spectral case. In both instances, the echoes are organized in localized horizontal structures with a range extent typically between 50 and 80 km. The fast-narrow structures tend to occur at higher altitudes than the well-known Farley-Buneman echoes, while the slow-narrow structures occur at lower altitudes (lower than 95 km). Both echo types come from regions with relatively small flow angles. Moreover the altitude of all echoes went down after 16:15 UT with the small-narrow echoes acquiring even smaller Doppler velocities. In large part thanks to the echo localization made feasible by interferometry, these new features are shedding some new important perspective on our understanding of auroral E-region radar echoes, particularly when it comes to spectra classified in the past as "Type III" and "Type IV" echoes.

  17. Measurement of the neutron capture cross-sections of Dy and Hf in the energy region from 0.003 eV to 50 keV

    CERN Document Server

    Cho, H J; Yamanoto, S; Fujita, Y; Kim, G Y; Ko, I S; Cho, M H; Namkung, W; Chang, J H; Ko, S K

    1999-01-01

    The capture cross-sections of Dy and Hf were measured in the energy region from 0.003 eV to 50 keV by using the neutron time-of-flight method at the 46 MeV electron linear accelerator of the Research Reactor Institute, Kyoto University. An assembly of Bi sub 4 Ge sub 3 O sub 1 sub 2 (BGO) scintillators, which was placed at a distance of 12.7 +- 0.02 m from the neutron source, was employed as a total absorption detector for the prompt capture gamma-ray measurement on the sample. In order to determine the neutron flux impinging on a capture sample, we used a Sm(n,gamma) reaction for thermal neutrons and the sup 1 sup 0 B(n,alpha gamma) reaction for neutrons from 0.003 eV to 50 keV. The absolute capture yield for the sample was obtained from the saturated resonance data at a large resonance of the sample. For the capture cross-section of Dy, the existing experimental data and the evaluated data in ENDF/B-VI and JEF-2.2 are closed to the present result. For the Hf capture cross-section, the previous experimental ...

  18. Water vapor motion signal extraction from FY-2E longwave infrared window images for cloud-free regions: The temporal difference technique

    Science.gov (United States)

    Yang, Lu; Wang, Zhenhui; Chu, Yanli; Zhao, Hang; Tang, Min

    2014-11-01

    The aim of this study is to calculate the low-level atmospheric motion vectors (AMVs) in clear areas with FY-2E IR2 window (11.59-12.79 μm) channel imagery, where the traditional cloud motion wind technique fails. A new tracer selection procedure, which we call the temporal difference technique, is demonstrated in this paper. This technique makes it possible to infer low-level wind by tracking features in the moisture pattern that appear as brightness temperature ( T B) differences between consecutive sequences of 30-min-interval FY-2E IR2 images over cloud-free regions. The T B difference corresponding to a 10% change in water vapor density is computed with the Moderate Resolution Atmospheric Transmission (MODTRAN4) radiative transfer model. The total contribution from each of the 10 layers is analyzed under four typical atmospheric conditions: tropical, midlatitude summer, U.S. standard, and midlatitude winter. The peak level of the water vapor weighting function for the four typical atmospheres is assigned as a specific height to the T B "wind". This technique is valid over cloud-free ocean areas. The proposed algorithm exhibits encouraging statistical results in terms of vector difference (VD), speed bias (BIAS), mean vector difference (MVD), standard deviation (SD), and root-mean-square error (RMSE), when compared with the wind field of NCEP reanalysis data and rawinsonde observations.

  19. Viral and Antibody Prevalence of Hepatitis E in European Wild Boars (Sus scrofa) and Hunters at Zoonotic Risk in the Latium Region.

    Science.gov (United States)

    Montagnaro, S; De Martinis, C; Sasso, S; Ciarcia, R; Damiano, S; Auletta, L; Iovane, V; Zottola, T; Pagnini, U

    2015-07-01

    Hepatitis E virus (HEV) is a member of the genus Hepevirus within the family Hepeviridae. Hepatitis E is recognized as a zoonosis, and swine and wild boars (Sus scrofa) are known reservoirs of HEV infection. The aim of this study was to investigate the presence of HEV in wild boars and hunters exposed to infection in central Italy (Latium region). During the hunting season, blood samples were collected from 228 wild boars and 20 hunters. The seroprevalence of HEV infection was determined using a commercial enzyme-linked immunosorbent assay, previously validated for use in man, pigs and wild boars. The estimated HEV seroprevalence in wild boars and in hunters was 40.7% (93/228; 95% confidence interval [CI] 34.4-47.1%) and 25% (5/20; 95% CI 6.1-43.9%), respectively. Liver samples were collected from the boars and HEV RNA was detected by nested reverse transcriptase polymerase chain reaction. Fifty-five of 164 tested wild boar liver samples (33.5%; 95% CI 26.2-40.7%) and three of 20 (15.0%; 95% CI 1.3-28.7%) tested human serum samples were positive for HEV RNA. Phylogenetic analysis of the nucleotide sequences obtained from PCR products indicated that the HEV strains present in wild boars and the human population all belonged to genotype 3, supporting the zoonotic role of wild boars in the spread of HEV infection.

  20. Breastfeeding and the nutritional transition in the Latin American and Caribbean Region: a success story? Amamentação e transição nutricional na América Latina e Caribe: um caso bem-sucedido?

    Directory of Open Access Journals (Sweden)

    Rafael Pérez-Escamilla

    2003-01-01

    Full Text Available The objectives of this paper are to examine recent breastfeeding duration trends in Latin America and the Caribbean to document: (a rural-urban differentials, (b differences in educational levels, and (c changes in breastfeeding duration across time. Secondary data analyses were conducted with 23 Demographic and Health Surveys collected between the mid-1980s and mid-1990s. Results indicate that median breastfeeding duration is still greater in rural (as compared to urban areas and among less (versus more educated women, although these differentials are decreasing with time. In five of the six countries examined for secular trends, breastfeeding duration continues to increase in both rural and urban areas. Breastfeeding duration in urban and rural areas was strongly correlated within countries. Breastfeeding duration improved more among women with the highest and declined among those with the lowest levels of education. Results indicate that breastfeeding duration has increased in Latin America and the Caribbean at a time when the opposite was predicted, given the region's increased urbanization. Breastfeeding protection policies and promotion programs may explain part of the increase in breastfeeding duration.Os objetivos deste artigo incluem examinar tendências recentes na duração da amamentação na América Latina e Caribe e documentar: (a diferenciais entre áreas rurais e urbanas, (b diferenças em escolaridade materna e (c mudanças na duração do aleitamento materno ao longo do tempo. Foram realizadas análises de dados secundários a partir de 23 pesquisas demográficas em saúde conduzidas entre meados das décadas de 80 e 90. Os resultados indicam que a duração mediana da amamentação continua sendo maior nas áreas rurais comparadas com as urbanas e entre mulheres com menos escolaridade, embora tais diferenças estejam diminuindo ao longo do tempo. Em cinco dos seis países estudados em relação a tendências seculares

  1. Distribuição regional e socioeconômica da disponibilidade domiciliar de alimentos no Brasil em 2008-2009 Distribución regional y socioeconómica de la disponibilidad domiciliaria de alimentos en Brasil, 2008-2009 Regional and socioeconomic distribution of household food availability in Brazil, in 2008-2009

    Directory of Open Access Journals (Sweden)

    Renata Bertazzi Levy

    2012-02-01

    Full Text Available OBJETIVO: Descrever a distribuição regional e socioeconômica da disponibilidade domiciliar de alimentos no Brasil. MÉTODOS: Estudo com dados secundários da Pesquisa de Orçamentos Familiares 2008-2009, realizada pelo Instituto Brasileiro de Geografia e Estatística sobre aquisições de alimentos e bebidas para consumo domiciliar. As quantidades de alimentos, registradas durante sete dias consecutivos nos 55.970 domicílios brasileiros amostrados, foram transformadas em calorias e nutrientes. Indicadores de qualidade da dieta foram construídos e analisados segundo estratos socioeconômicos e regionais da população brasileira. RESULTADOS: O teor protéico da disponibilidade alimentar mostrou-se adequado em todos os estratos regionais e econômicos. Em contrapartida, observou-se excesso de açúcares livres e de gorduras em todas as regiões, especialmente nas regiões Sul e Sudeste. A proporção de gorduras saturadas foi elevada no meio urbano e consistente com a maior participação de produtos de origem animal. A presença insuficiente de frutas, legumes e verduras foi comum em todas as regiões. Intensificação do teor de gorduras e diminuição do teor de carboidratos da dieta foram observadas com o aumento da renda. CONCLUSÕES: As características negativas da qualidade da dieta da população brasileira observadas ao final da primeira década do século XXI conferem alta prioridade para políticas públicas de promoção da alimentação saudável.OBJETIVO: Describir la distribución regional y socioeconómica de la disponibilidad domiciliaria de alimentos en Brasil. MÉTODOS: Estudio con datos secundarios de la Investigación de Presupuestos Familiares 2008-2009, realizada por el Instituto Brasileño de Geografía y Estadística sobre adquisiciones de alimentos y bebidas para consumo domiciliario. Las cantidades de alimentos, registradas durante siete días consecutivos en los 55.970 domicilios brasileños muestreados, fueron

  2. Avaliação do modelo regional eta utilizando as análises do CPTEC e NCEP Evaluation of the eta regional model using the analysis of CPTEC and NCEP

    Directory of Open Access Journals (Sweden)

    Rildo Gonçalves de Moura

    2010-03-01

    Full Text Available Os modelos numéricos de tempo são ferramentas essenciais para a previsão de curto e longo prazo, permitindo realizar a previsão com vários dias de antecedência. O conhecimento do desempenho dos modelos e dos erros sistemáticos a eles associados, é de suma importância, pois permite avaliar a capacidade dos mesmos em captar os processos físicos da atmosfera. Com intuito de melhorar a qualidade da previsão de tempo na América do Sul, disponibilizada no Centro de Previsão de Tempo e Estudos Climáticos (CPTEC, este trabalho avaliou as previsões de precipitação e pressão ao nível médio do mar para o prazo de até 120 horas, utilizando o erro médio (EM e a raiz do erro médio quadrático (REMQ no período de dezembro de 2007 a fevereiro de 2008. O modelo utilizado foi o ETA (40 km, com duas entradas distintas de dados, as análises do Physical-space Statistical Analysis System (PSAS (ETA-I e do National Centers for Environmental Predictions (NCEP (ETA-II. Os resultados mostraram, para ambas as análises, uma tendência de superestimativa (valores positivos do erro médio da precipitação sobre a Região Norte do Brasil, principalmente para 24 horas de previsão. Em relação à pressão ao nível médio do mar (PNMM foi possível verificar claramente que o ETA-I apresenta melhores resultados em comparação com o ETA-II, cujos valores de pressão se aproximaram bastante do observado, principalmente nas primeiras horas de integração.The numerical weather models are essential tools for predicting short and long term, allowing the prediction of weather conditions several days in advance. The knowledge of models performance and the systematic errors associated with them is extremely important because it allows to evaluate the ability to capture the physical processes of the atmosphere. In order to improve the quality of weather forecast in South America, available at Center for Weather Forecast and Climate Studies (CPTEC, this study

  3. The South American energy policies: regional problems and national logics; As politicas energeticas Sul-Americanas: problemas regionais e logicas nacionais

    Energy Technology Data Exchange (ETDEWEB)

    Le Prioux, Bruna [Centro de Pesquisa e Documentacao da America Latina (CREDAL) (France)

    2010-07-01

    sustainable development, interdependence and energy governance, to relate the national and international energy policies. Energy national policies are relevant factors to be considered when a regional integration is studied. In fact, energy advantages and deficiencies emerge in regional scenario, showing that the interdependences depend on national logics and strategies. In this sense, we consider that the effect of energy integration in South America is unsatisfying because national policies do not converge. The advantages of integration (i.e. commerce increase, ensuring supplies and reducing price volatility) are neutralized without this countries' coordination. (author)

  4. Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey.

    Science.gov (United States)

    Suzuki, Saori; Mori, Ken-Ichi; Higashino, Atsunori; Iwasaki, Yuki; Yasutomi, Yasuhiro; Maki, Noboru; Akari, Hirofumi

    2016-01-01

    The development of effective hepatitis C virus (HCV) vaccines is essential for the prevention of further HCV dissemination, especially in developing countries. Therefore the aim of this study is to establish a feasible and immunocompetent surrogate animal model of HCV infection that will help in evaluation of the protective efficacy of newly developing HCV vaccine candidates. To circumvent the narrow host range of HCV, an HCV genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B (GBV-B), which is closely related to HCV, was generated. The chimera between HCV and GBV-B, named HCV/G, replicated more efficiently as compared with the HCV clone in primary marmoset hepatocytes. Furthermore, it was found that the chimera persistently replicated in a tamarin for more than 2 years after intrahepatic inoculation of the chimeric RNA. Although relatively low (virus. Our results will help establish a novel non-human primate model for HCV infection on the basis of the HCV/G chimera in the major framework of the HCV genome.

  5. Identification of Highly Deformed Even-Even Nuclides in the Neutron- and Proton-Rich Regions of the Nuclear Chart from the B(E2) and E2 Predictions in the Generalized Differential Equation Model

    CERN Document Server

    Nayak, R C

    2015-01-01

    We identify here possible occurrence of large deformations in the neutron- and proton-rich regions of the nuclear chart from extensive predictions of the values of the reduced quadrupole transition probability B-E2 for the transition from the ground state to the first 2+ state and the corresponding excitation energy E2 of even-even nuclei in the recently developed Generalized Differential Equation model exclusively meant for these physical quantities. This is made possible from our analysis of the predicted values of these two physical quantities and the corresponding deformation parameters derived from them such as the quadrupole deformation beta-2, the ratio of beta-2 to the Weisskopf single-particle beta-2 and the intrinsic electric quadruplole moment , calculated for a large number of both known as well as hitherto unknown even-even isotopes of Oxygen to Fermium (Z=8 to 100). Our critical analysis of the resulting data convincingly support possible existence of large collectivity for the nuclides 30,32 Ne...

  6. Investigation of Regional Fractures and Cu Mineralization Relationships in the Khezrabad and Shahr-e-Babak Area: Using Fry and Fractal analysis

    Directory of Open Access Journals (Sweden)

    Alireza Zarasvandi

    2015-10-01

    Full Text Available Introduction Two main principal aspects for the genesis of porphyry copper deposits have been determined. The first genetic model concerns the petrologic and geochemical processes and the other relates the genesis to crustal deformation and geodynamic conditions (Kesler, 1997. Recent studies (e.g., Padilla Garza et al., 2001 show that the generation and emplacement of porphyry copper deposits may not only be dependent on magmatic and hydrothermal processes, but also that the regional and local tectonic setting plays an important role. Therefore in determining the suitable setting for emplacement of copper and other porphyry intrusions, determination of location of partial melting of the lower crust, generation of batholiths, and their volatile-rich derivative intrusions in the crust seems to be necessary (Carranza and Hale, 2002. Almost all porphyry copper deposits in Iran are located in the Urumieh-Dokhtar magmatic belt. These deposits show distinct spatial and temporal relationship with Miocene granodiorite plutonic rocks emplaced along strike slip faults (Mehrabi et al., 2005. Accordingly, the tectonic setting of ore deposits seem to be the most important factor for regional exploration of porphyry copper systems (Vearncombe and Vearncombe, 1999. There are several methods for analysis of distribution of ore deposits. In this research the role of structural control in the spatial distribution of porphyry deposits has been studied using Fry and Fractal methods. Here, the Fry method is used as a complementary method for Fractal analysis. Materials and methods Fry analysis is a self-adaptive method that is used for point objects. Fry analysis offers a visual approach to quantify the spatial trends in groups of point objects. Fry analysis can also be used to search for anisotropies in the distribution of point objects. More specifically it can be used to investigate whether a distribution of point objects occurs along linear trends, and whether

  7. Classificação e tendências climáticas em Lavras, MG Climatic classification and tendencies in Lavras region, MG

    Directory of Open Access Journals (Sweden)

    Antonio Augusto Aguilar Dantas

    2007-12-01

    Full Text Available Objetivou-se com este trabalho avaliar a tendência de dados climáticos nos últimos 14 anos, na região de Lavras, MG, comparando-os com aqueles da série histórica do período de 1961 a 1990. Foi utilizado o método do balanço hídrico de Thornthwaite & Mather (1955para os dados do período de 1961-1990 e para os dados recentemente observados de 1991-2004. O método do balanço hídrico de Thornthwaite considera a evapotranspiração potencial, a precipitação pluvial, o armazenamento de água no solo e seu subsequente uso. Este método também apresenta os períodos de excesso e deficiência hídrica, então utilizados no método de classificação climática de Thornthwaite para determinar os índices de umidade e de aridez. Os índices resultaram na fórmula climática de Thornthwaite que nesta comparação, mudou de B3 r B'3 a' para B2 r B'3 a' no período mais recente. A classificação climática de Köppen, também utilizada neste trabalho não apresentou diferenças para ambos os períodos, permanecendo Cwa.The purpose of this study was to evaluate the climatic data tendency in the last 14 years of monthly rainfall and temperatures in Lavras region, MG state , compared to those of the historical series of 1961-1990 period. The Thornthwaite's water balance method was employed for the climatological data of 1961-1990 and for the last observed data of 1991-2004. The Thornthwaite's & Mather´s water balance method considers the potential evapotranspiration, the rainfall, the storage of water in the ground and its subsequent use. This method also shows hidric excess and deficiency periods, then used on the Thornthwaite's climatic classification method to determine the moisture and aridity index of the climate. The index resulted on the Thornthwaite's climatic formula wich changed from B3 r B'3 a' to B2 r B'3 a' in the most recent reiod. The Köppen climatic classification method, also employed in this work, showed no changes, remaining

  8. Epidemiologia e diferenças regionais da retinopatia diabética em Pernambuco, Brasil Epidemiology and regional differences of diabetic retinopathy in Pernambuco, Brazil

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Gonçalves Escarião

    2008-04-01

    Full Text Available OBJETIVOS: Avaliar os dados de freqüência e estadiamento da retinopatia diabética em Pernambuco, Brasil, comparando a região metropolitana com cidades do interior do estado. MÉTODOS: Os prontuários de 2.223 pacientes diabéticos (1.568 mulheres e 655 homens; idade média de 58,4 ± 12,0 anos; duração média do diabetes de 8,1 ± 6,3 anos, que fizeram parte de um programa de triagem para retinopatia diabética na Fundação Altino Ventura entre os meses de junho de 2004 e junho de 2005, foram revistos quanto à presença de retinopatia. Os pacientes foram divididos em dois grupos quanto à origem: grupo I, pacientes residentes em Recife e região metropolitana; grupo II, pacientes residentes no interior do estado de Pernambuco. RESULTADOS: No grupo I, 477 (24,2% pacientes apresentavam retinopatia diabética ao passo que no grupo II, 89 (39,4% pacientes (pPURPOSE: To evaluate the prevalence and severity of diabetic retinopathy among patients cared for in a screening program in Pernambuco, Brazil, comparing regional differences between urban and rural zones. METHODS: The charts of 2,223 diabetic patients (1,568 females and 655 males; mean age 59.3 ± 12.0 years; mean duration of diabetes 8.1 ± 6.3 years that took part in a screening program for diabetic retinopathy at Altino Ventura Foundation from June 2004 to June 2005 were reviewed for the presence of the disease. Patients were divided into two groups: group I, patients living in Recife and the metropolitan area; group II, patients living in the interior of Pernambuco state. RESULTS: In group I, 477 (24.2% patients had diabetic retinophathy, while in group II, 89 (39.4% patients (p<0.0001. The frequency of proliferative diabetic retinophathy, macular edema, vitreous hemorrhage and retinal detachment was higher in group II patients (p<0.05. CONCLUSIONS: Patients living in the interior of Pernambuco state have a higher incidence of diabetic retinophathy and the advanced forms than

  9. Desempenho reprodutivo de vacas Nelore no Norte e Nordeste do Brasil Reproductive performance of Nelore cows in the North and Northeast Regions of Brazil

    Directory of Open Access Journals (Sweden)

    Danielle Maria Machado Ribeiro Azevêdo

    2006-06-01

    Full Text Available Objetivou-se com este trabalho estimar os parâmetros genéticos e fenotípicos de características reprodutivas de fêmeas de rebanhos das regiões Norte e Nordeste do Brasil. As características estudadas foram idade ao primeiro parto (IPP, intervalo de partos (IDP, período de serviço (PS, número de serviços por concepção (NSC e período de gestação (PG. Os modelos utilizados para cada característica foram selecionados por meio do procedimento MIXED do programa SAS e os componentes de variância foram estimados pelo método da Máxima Verossimilhança Restrita Livre de Derivada, utilizando-se o software MTDFREML. As médias observadas para IPP, IDP, PS, NSC e PG foram 45,14±10,83 meses; 465,55±128,49 dias; 165,76±110,29 dias; 1,34±0,67 serviços e 295,03±5,85 dias, respectivamente. As estimativas de herdabilidade para IPP, IDP, PS, NSC e PG foram, respectivamente, 0,21±0,05; 0,05±0,02; 0,32±0,11; 0,05±0,04 e 0,12±0,04. As estimativas de repetibilidade encontradas para IDP, PS, NSC e PG foram, nesta ordem, 0,05; 0,63; 0,09 e 0,22. Os resultados sugerem que, apesar da pequena variabilidade genética para a maioria das características, a IPP e o PG são características reprodutivas que devem ser incluídas em programas de seleção. A elevada herdabilidade obtida para PS pode ser decorrente da estrutura dos dados analisados, provenientes, em sua grande maioria, de um mesmo rebanho. O baixo valor para a repetibilidade do IDP indica que o descarte de fêmeas com base no desempenho ao seu primeiro intervalo de partos pode ocasionar a eliminação de animais que poderão apresentar boa eficiência reprodutiva no futuro.The objective of this study was to estimate genetic and phenotypic parameters for reproductive traits of Nelore cows raised in the North and Northeast regions of Brazil. The traits studied were age at first calving (AFC, calving interval (CI, post-partum interval (PPI, number of services per conception (NSC and

  10. Building an eScience Thesaurus for Librarians: A Collaboration Between the National Network of Libraries of Medicine, New England Region and an Associate Fellow at the National Library of Medicine

    OpenAIRE

    Kevin Read; Andrew T. Creamer; Donna Kafel; Robert J. Vander Hart; Martin, Elaine R

    2013-01-01

    Objective: In response to the growing interest and adoption of eScience roles by librarians, those from the National Network of Libraries of Medicine, New England Region (NN/LM NER) and an Associate Fellow from the National Library of Medicine collaborated to build an eScience Thesaurus. The Thesaurus will introduce librarians to terminology and concepts in eScience, point to relevant literature and resources on data and digital research topics, and provide links to interviews with librarians...

  11. Comparison and validation of Logistic Regression and Analytic Hierarchy Process models of landslide susceptibility in monoclinic regions. A case study in Moldavian Plateau, N-E Romania

    Science.gov (United States)

    Ciprian Margarint, Mihai; Niculita, Mihai

    2014-05-01

    The regions with monoclinic geological structure are large portions of earth surface where the repetition of similar landform patterns is very distinguished, the scarps of cuestas being characterized by similar values of morphometrical variables. Landslides are associated with these scarps of cuestas and consequently, a very high value of landslide susceptibility can be reported on its surface. In these regions, landslide susceptibility mapping can be realized for the entire region, or for test areas, with accurate, reliable, and available datasets, concerning multi-temporal inventories and landslide predictors. Because of the similar geomorphologic and landslide distribution we think that if any relevance of using test areas for extrapolating susceptibility models is present, these areas should be targeted first. This study case try to establish the level of usability of landslide predictors influence, obtained for a 90 km2 sample located in the northern part of the Moldavian Plateau (N-E Romania), in other areas of the same physio-geographic region. In a first phase, landslide susceptibility assessment was carried out and validated using logistic regression (LR) approach, using a multiple landslide inventory. This inventory was created using ortorectified aerial images from 1978 and 2005, for each period being considered both old and active landslides. The modeling strategy was based on a distinctly inventory of depletion areas of all landslide, for 1978 phase, and on a number of 30 covariates extracted from topographical and aerial images (both from 1978 and 2005 periods). The geomorphometric variables were computed from a Digital Elevation Model (DEM) obtained by interpolation from 1:5000 contour data (2.5 m equidistance), at 10x10 m resolution. Distance from river network, distance from roads and land use were extracted from topographic maps and aerial images. By applying Akaike Information Criterion (AIC) the covariates with significance under 0.001 level

  12. Disponibilidade de energia e nutrientes nos domicílios: o contraste entre as regiões Norte e Sul do Brasil Energy and nutrients disposal in residences: the contrast between north and south regions of Brazil

    Directory of Open Access Journals (Sweden)

    Carla Cristina Enes

    2009-08-01

    Full Text Available Com o objetivo de analisar a disponibilidade domiciliar de energia, a participação relativa dos macronutrientes no Valor Energético Total (VET e a contribuição dos diferentes grupos de alimentos na energia disponível nos domicílios das regiões Norte e Sul do país, segundo o rendimento mensal familiar, foi proposto o presente estudo. Utilizou-se para a elaboração das análises os microdados da Pesquisa de Orçamentos Familiares - 2002/2003 realizada pelo Instituto Brasileiro de Geografia e Estatística (IBGE. Para as análises nutricionais, utilizou-se o software Virtual Nutri. O teste de regressão linear múltipla foi aplicado para analisar o efeito dos rendimentos sobre a disponibilidade de energia e nutrientes. Verificou-se uma relação inversa entre a participação dos carboidratos no VET e a renda. A contribuição dos lipídios para o VET apresentou tendência de crescimento, de acordo com o aumento da renda. Quanto à participação dos distintos grupos de alimentos no VET, destaca-se a reduzida contribuição energética das frutas, verduras e legumes para praticamente a totalidade dos grupamentos familiares. Foram identificadas indesejáveis contribuições (consideradas excessivas dos doces, açúcares e refrigerantes para o VET disponível para as famílias de ambas as regiões estudadas.This study was proposed to analyze the domiciliary energy disposal, the relative participation of macronutrients in the Total Energy Value (VET and the contribution of different food groups in the disposal energy in residences of the North and South regions of Brazil according to the monthly family income. It was used the micro data of the Family Budget Research - POF related to the period of 2002/2003 which was carried out by the Brazilian Institute of Geography and Statistics - IBGE. The nutritional analyses were made by using the Virtual Nutri software. The multiple linear regression test was used to capture the income effect over

  13. Effects of DSP4 and dizolcipine on connectivity of solid E19 cortical grafts to ablated SmI region of adult rats; an in vivo electrophysiological study.

    Science.gov (United States)

    Zarei, Mojtaba; Stephenson, John D

    2002-08-30

    The functional connectivity of an embryonic graft implanted into the lesioned somatosensory cortex and the effect of DSP4 (a selective noradrenergic neurotoxin to noradrenergic terminals) and dizolcipine (a non-competitive NMDA receptor antagonist), was studied electrophysiologically. The forepaw representational area of the rat primary somatosensory cortex was lesioned unilaterally and, 3-4 weeks later, tissue from the same region of E19 rat embryos was implanted into the cavity. At 7-9 months later, the rats were anaesthetized and single unit activity was recorded from the grafts in response to contralateral forepaw, ipsilateral hindpaw and contralateral hindpaw stimulation and compared with that obtained in control rats, in rats pretreated with dizolcipine immediately after lesioning and in rats given DSP4 24 h before transplantation. Neurones within the graft were integrated into the host brain and developed a pattern of representation similar to that of intact rats, but with a reduced proportion of neurones exhibiting short-latency response to contralateral forepaw stimulation and an increased proportion responding to stimulation of more than one paw. Pretreatment with dizolcipine did not increase short-latency responses to stimulation of contralateral forepaw stimulation however pretreatment with DSP4 reduced such responses and increased proportion of inhibitory responses. It was concluded that the noradrenergic system plays an important role in establishing host-graft connectivity. The importance of further pharmacological studies on host-graft connectivity and the relation of such connections to neural plasticity were discussed.

  14. Typical values of the electric drift E × B/B2 in the inner radiation belt and slot region as determined from Van Allen Probe measurements

    Science.gov (United States)

    Lejosne, Solène; Mozer, F. S.

    2016-12-01

    The electric drift E × B/B2 plays a fundamental role for the description of plasma flow and particle acceleration. Yet it is not well-known in the inner belt and slot region because of a lack of reliable in situ measurements. In this article, we present an analysis of the electric drifts measured below L 3 by both Van Allen Probes A and B from September 2012 to December 2014. The objective is to determine the typical components of the equatorial electric drift in both radial and azimuthal directions. The dependences of the components on radial distance, magnetic local time, and geographic longitude are examined. The results from Van Allen Probe A agree with Van Allen Probe B. They show, among other things, a typical corotation lag of the order of 5 to 10% below L 2.6, as well as a slight radial transport of the order of 20 m s-1. The magnetic local time dependence of the electric drift is consistent with that of the ionosphere wind dynamo below L 2 and with that of a solar wind-driven convection electric field above L 2. A secondary longitudinal dependence of the electric field is also found. Therefore, this work also demonstrates that the instruments on board Van Allen Probes are able to perform accurate measurements of the electric drift below L 3.

  15. Cartilha Ada e Edu : de produção regional à circulação nacional (1977-1985

    Directory of Open Access Journals (Sweden)

    Cancionila Janzkovski Cardoso

    2013-01-01

    Full Text Available El artículo presenta los resultados de un estudio cuyo objetivo general es contribuir a la sistematización y difusión de una historia del libro de Mato Grosso, tras la investigación de la producción, difusión y circulación de la cartilla Ada e Edu, elaborada en 1977. La investigación se inscribe en la historia de la alfabetización, y se guía por las referencias teóricas y metodológicas relacionadas con la historia cultural y la historia del libro. La propuesta metodológica se basó en el circuito de las comunicaciones, modelo propuesto por Robert Darnton, para examinar la ruta de la cartilla regional Nuestra tierra nuestra gente , más tarde transformada en la cartilla Ada y Edu, editada y comercializada a nivel nacional por la Editora Bloch. Ha sido posible reconstruir aspectos de la producción y la circulación de esta cartilla en el contexto de Mato Grosso y registrar elementos de la circulación a nivel nacional, por medio del Programa Nacional do Livro Didático.

  16. Measurement of the polarized structure function σL T' for p ( e→ , e' π+ ) n in the Δ ( 1232 ) resonance region

    Science.gov (United States)

    Joo, K.; Smith, L. C.; Aznauryan, I. G.; Burkert, V. D.; Minehart, R.; Adams, G.; Ambrozewicz, P.; Anciant, E.; Anghinolfi, M.; Asavapibhop, B.; Asryan, G.; Audit, G.; Auger, T.; Avakian, H.; Bagdasaryan, H.; Ball, J. P.; Barrow, S.; Batourine, V.; Battaglieri, M.; Beard, K.; Bektasoglu, M.; Benmouna, N.; Bianchi, N.; Biselli, A. S.; Boiarinov, S.; Bonner, B. E.; Bouchigny, S.; Bradford, R.; Branford, D.; Briscoe, W. J.; Brooks, W. K.; Bültmann, S.; Butuceanu, C.; Calarco, J. R.; Carman, D. S.; Carnahan, B.; Cetina, C.; Chen, S.; Ciciani, L.; Cole, P. L.; Cords, D.; Corvisiero, P.; Crabb, D.; Crannell, H.; Cummings, J. P.; de Sanctis, E.; Devita, R.; Degt